strainid	orf	gene	zyg	qualifier	SGTC_3090|9117696.score	SGTC_3090|9117696.expt.zyg.pval	SGTC_3090|9117696.expt.zyg.significant	SGTC_3090|9117696.expt.zyg.rank	strain.pval	strain.rank	clearance	Fclass	Fterms.BP	Fterms.CC	Fterms.complex	description	GO_process	GO_function	GO_component
YOR246C	YOR246C	ENV9	hom	Verified	8.66799473116053	2.19898536830111e-18	yes	1	7.84517392867376e-17	21	NA	FF|FT	OXIDATION-REDUCTION PROCESS|VACUOLAR PROTEIN PROCESSING			Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and defects in vacuolar morphology; has similarity to oxidoreductases, found in lipid particles; required for replication of Brome mosaic virus in S. cerevisiae, a model system for studying replication of positive-strand RNA viruses in their natural hosts	vacuole organization|vacuolar protein processing	oxidoreductase activity	lipid particle
YDL070W	YDL070W	BDF2	hom	Verified	7.27469118067385	1.73606913890114e-13	yes	2	2.11745382468562e-14	1	NA	FT	CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE	NUCLEUS		Protein involved in transcription initiation; acts at TATA-containing promoters; associates with the basal transcription factor TFIID; contains two bromodomains; corresponds to the C-terminal region of mammalian TAF1; redundant with Bdf1p; protein abundance increases in response to DNA replication stress	negative regulation of heterochromatin assembly	histone acetyl-lysine binding|core promoter binding|histone binding|TFIID-class transcription factor binding	nucleus
YMR242C	YMR242C	RPL20A	hom	Verified	6.96370560940637	1.65718422088949e-12	yes	3	2.64733087911837e-11	7	NA	FF|FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L20A; homologous to mammalian ribosomal protein L18A, no bacterial homolog; RPL20A has a paralog, RPL20B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YPL057C	YPL057C	SUR1	hom	Verified	5.51917826553891	1.70294275884609e-08	yes	4	1.08713607923056e-08	23	NA	FT	LIPID METABOLISM			Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit; forms a complex with regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Csh1p; SUR1 has a paralog, CSH1, that arose from the whole genome duplication	glycosphingolipid biosynthetic process|mannosyl-inositol phosphorylceramide metabolic process|sphingolipid biosynthetic process	mannosyltransferase activity|transferase activity, transferring glycosyl groups	integral to membrane|intracellular
YGL005C	YGL005C	COG7	hom	Verified	5.32329175466677	5.09530507414057e-08	yes	5	0.00352468558703062	120	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM|MITOCHONDRION|GOLGI APPARATUS		Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments	intra-Golgi vesicle-mediated transport|CVT pathway	molecular_function	mitochondrion|Golgi transport complex
YNL229C	YNL229C	URE2	hom	Verified	5.16515169858406	1.20121999337981e-07	yes	6	2.57373780908086e-05	67	NA	FF|FT	PROTEIN LOCALIZATION			Nitrogen catabolite repression transcriptional regulator that acts by inhibition of GLN3 transcription in good nitrogen source; has glutathione peroxidase activity and can mutate to acquire GST activity; altered form creates [URE3] prion	regulation of nitrogen utilization|response to aluminum ion|protein urmylation|cytoplasmic sequestering of transcription factor	glutathione peroxidase activity|phosphoprotein binding|transcription corepressor activity	cytosol
YDR354W	YDR354W	TRP4	hom	Verified	4.98477668301858	3.10167091544617e-07	yes	7	0.010436301169613	279	NA	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosphoribosylation of anthranilate, subject to the general control system of amino acid biosynthesis	tryptophan biosynthetic process	anthranilate phosphoribosyltransferase activity	nucleus|cytoplasm
YKL008C	YKL008C	LAC1	hom	Verified	4.89643835620733	4.8794621073575e-07	yes	8	2.04902130201649e-07	1	NA	FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Ceramide synthase component, involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lag1p	replicative cell aging|ceramide biosynthetic process	sphingosine N-acyltransferase activity	integral to membrane|endoplasmic reticulum
YJR122W	YJR122W	IBA57	hom	Verified	4.85591963812367	5.99146474980509e-07	yes	9	2.93809357713465e-05	29	NA	FF|FT	COFACTOR METABOLISM	MITOCHONDRION		Mitochondrial matrix protein involved in the incorporation of iron-sulfur clusters into mitochondrial aconitase-type proteins; activates the radical-SAM family members Bio2p and Lip5p; interacts with Ccr4p in the two-hybrid system	iron-sulfur cluster assembly	molecular_function	mitochondrion|mitochondrial matrix
YDL100C	YDL100C	GET3	hom	Verified	4.57588634692452	2.37103974615661e-06	yes	10	0.00027983878640276	58	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING|NUCLEOTIDE METABOLISM	ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Guanine nucleotide exchange factor for Gpa1p; amplifies G protein signaling; subunit of the GET complex, which is involved in Golgi to ER trafficking and insertion of proteins into the ER membrane; has low-level ATPase activity; protein abundance increases in response to DNA replication stress	retrograde vesicle-mediated transport, Golgi to ER|pheromone-dependent signal transduction involved in conjugation with cellular fusion|response to heat|protein insertion into ER membrane|response to metal ion|posttranslational protein targeting to membrane	ATPase activity|guanyl-nucleotide exchange factor activity	endoplasmic reticulum|GET complex
YJL075C_d	YJL075C	APQ13	hom	Dubious	4.56249996038056	2.52740515886668e-06	yes	11	1.99933172499719e-06	9	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 85% of ORF overlaps the verified gene NET1; null mutant is sensitive to sorbate	Unknown	Unknown	Unknown
YBR133C	YBR133C	HSL7	hom	Verified	4.39224502273412	5.60930814424001e-06	yes	12	3.26066311637501e-05	10	NA	FT	CELL CYCLE|CHROMATIN ORGANIZATION|CELL DIVISION	SITE OF POLARIZED GROWTH		Protein arginine N-methyltransferase; exhibits septin and Hsl1p-dependent bud neck localization and periodic Hsl1p-dependent phosphorylation; required along with Hsl1p for bud neck recruitment, phosphorylation, and degradation of Swe1p; relocalizes away from bud neck upon DNA replication stress	G2/M transition of mitotic cell cycle|regulation of cell cycle	protein-arginine omega-N symmetric methyltransferase activity|protein-arginine omega-N monomethyltransferase activity	cellular bud neck
YAL051W	YAL051W	OAF1	hom	Verified	4.15075320789152	1.6569146716736e-05	yes	13	5.23973212146422e-06	9	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|GENE SILENCING	NUCLEUS		Oleate-activated transcription factor; acts alone and as a heterodimer with Pip2p; activates genes involved in beta-oxidation of fatty acids and peroxisome organization and biogenesis; OAF1 has a paralog, PIP2, that arose from the whole genome duplication	cellular response to oleic acid|positive regulation of fatty acid beta-oxidation|positive regulation of chromatin silencing at telomere|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YHR077C	YHR077C	NMD2	hom	Verified	4.13619758060424	1.76554092910732e-05	yes	14	1.52341142101004e-05	12	NA					Protein involved in the nonsense-mediated mRNA decay (NMD) pathway; interacts with Nam7p and Upf3p; involved in telomere maintenance	nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay|translational frameshifting	molecular_function	polysome|cytoplasm
YBR027C_d	YBR027C	YBR027C	hom	Dubious	3.82838199019174	6.44942262991204e-05	yes	15	3.03520546657263e-05	24	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YJL028W	YJL028W	YJL028W	hom	Verified	3.77053641122134	8.14485161180355e-05	yes	16	1.09165705592485e-05	6	NA					Protein of unknown function; may interact with ribosomes, based on co-purification experiments	biological_process	molecular_function	ribosome
YDL090C	YDL090C	RAM1	hom	Verified	3.66519358417305	0.000123575782094116	yes	17	0.00265576094993241	105	NA	FF|FT	PROTEIN PRENYLATION			Beta subunit of the CAAX farnesyltransferase (FTase) that prenylates the a-factor mating pheromone and Ras proteins; required for the membrane localization of Ras proteins and a-factor; homolog of the mammalian FTase beta subunit	protein farnesylation	protein farnesyltransferase activity	protein farnesyltransferase complex
YHR203C	YHR203C	RPS4B	hom	Verified	3.64919540277419	0.000131531476764334	yes	18	0.000552093506053065	27	NA	FT	TRANSLATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S4, no bacterial homolog; RPS4B has a paralog, RPS4A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic small ribosomal subunit|90S preribosome
YDR462W	YDR462W	MRPL28	hom	Verified	3.62553505004263	0.000144181889902498	yes	19	0.00022621079039012	38	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YNL259C	YNL259C	ATX1	hom	Verified	3.53131211762768	0.000206751752635359	yes	20	0.000289567733528854	43	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|RESPONSE TO OXIDATIVE STRESS			Cytosolic copper metallochaperone that transports copper to the secretory vesicle copper transporter Ccc2p for eventual insertion into Fet3p, which is a multicopper oxidase required for high-affinity iron uptake	copper ion transport|cellular response to oxidative stress|cellular iron ion homeostasis	copper chaperone activity	cytosol
YNR066C_p	YNR066C	YNR066C	hom	Uncharacterized	3.51971123737076	0.000216008433250331	yes	21	0.000465738715979154	40	NA					Putative membrane-localized protein of unknown function	biological_process	molecular_function	integral to membrane|membrane
YDR011W	YDR011W	SNQ2	hom	Verified	3.51677161270814	0.000218414735871883	yes	22	0.00150346921482867	104	NA	FF|FT	NUCLEOTIDE METABOLISM	MITOCHONDRION|PLASMA MEMBRANE		Plasma membrane ATP-binding cassette (ABC) transporter, multidrug transporter involved in multidrug resistance and resistance to singlet oxygen species	response to drug	xenobiotic-transporting ATPase activity	mitochondrion|integral to membrane|plasma membrane
YDR249C_p	YDR249C	YDR249C	hom	Uncharacterized	3.42534571183582	0.000307008784479762	yes	23	8.92889378531922e-05	14	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YJR140C	YJR140C	HIR3	hom	Verified	3.40461017527611	0.000331292829209928	yes	24	0.000546845892674487	26	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION	NUCLEUS		Subunit of the HIR complex; a nucleosome assembly complex involved in regulation of histone gene transcription; involved in position-dependent gene silencing and nucleosome reassembly; ortholog of human CABIN1 protein	DNA replication-independent nucleosome assembly|regulation of transcription involved in G1/S phase of mitotic cell cycle|transcription elongation from RNA polymerase II promoter	nucleosome binding|DNA binding|transcription corepressor activity	HIR complex|nucleus
YNL130C-A_p	YNL130C-A	DGR1	hom	Uncharacterized	3.39132935966937	0.000347772302075572	yes	25	0.000130069024194033	19	NA	FT		MITOCHONDRION		Protein of unknown function; dgr1 null mutant is resistant to 2-deoxy-D-glucose	biological_process	molecular_function	cellular_component
YHR098C	YHR098C	SFB3	hom	Verified	3.37447123012278	0.000369788230648574	yes	26	0.000960425613537397	60	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS|SITE OF POLARIZED GROWTH		Component of the Sec23p-Sfb3p heterodimer of the COPII vesicle coat, required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sec24p and Sfb2p	cargo loading into COPII-coated vesicle	signal sequence binding	COPII vesicle coat|mating projection tip
YHR013C	YHR013C	ARD1	hom	Verified	3.35896581505603	0.000391173723480667	yes	27	0.000356955249832055	33	NA	FT	CHROMATIN ORGANIZATION		RIBOSOME	Subunit of protein N-terminal acetyltransferase NatA; NatA is comprised of Nat1p, Ard1p, and Nat5p; acetylates many proteins and thus affects telomeric silencing, cell cycle, heat-shock resistance, mating, and sporulation; human Ard1p levels are elevated in cancer cells; protein abundance increases in response to DNA replication stress	histone acetylation|N-terminal protein amino acid acetylation	peptide alpha-N-acetyltransferase activity	cytosolic ribosome|NatA complex
YNL099C	YNL099C	OCA1	hom	Verified	3.33717984563979	0.000423165822240584	yes	28	0.000724060397355969	73	NA	FF|FT	RESPONSE TO OXIDATIVE STRESS			Putative protein tyrosine phosphatase, required for cell cycle arrest in response to oxidative damage of DNA	cellular response to oxidative stress	protein tyrosine phosphatase activity	cytoplasm
YEL037C	YEL037C	RAD23	hom	Verified	3.33204000240269	0.000431059315583294	yes	29	0.000465895051545298	15	NA	FT	RESPONSE TO DNA DAMAGE|PROTEOLYSIS	NUCLEUS|MITOCHONDRION		Protein with ubiquitin-like N terminus, subunit of Nuclear Excision Repair Factor 2 (NEF2) with Rad4p that binds damaged DNA; enhances protein deglycosylation activity of Png1p; also involved, with Rad4p, in ubiquitylated protein turnover	proteasomal ubiquitin-dependent protein catabolic process|nucleotide-excision repair, DNA damage recognition|ER-associated protein catabolic process|protein deglycosylation	damaged DNA binding|ubiquitin binding|peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity|protein binding, bridging	proteasome complex|mitochondrion|nucleotide-excision repair factor 2 complex
YLR011W	YLR011W	LOT6	hom	Verified	3.31615539837338	0.000456325324635752	yes	30	0.000139082960285422	12	NA	FT	PROTEIN LOCALIZATION|OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		FMN-dependent NAD(P)H:quinone reductase, may be involved in quinone detoxification; expression elevated at low temperature; sequesters the Cin5p transcription factor in the cytoplasm in complex with the proteasome under reducing conditions	cellular response to oxidative stress|cytoplasmic sequestering of transcription factor	NAD(P)H dehydrogenase (quinone) activity|transcription factor binding	cytosol|nucleus|cytoplasm
YDR152W	YDR152W	GIR2	hom	Verified	3.28427447937843	0.000511226455440053	yes	31	0.000494585020175169	30	NA	FT	TRANSLATION			Highly-acidic cytoplasmic RWD domain-containing protein of unknown function; forms a complex with Rbg2p; interacts with Rbg1p and Gcn1p; associates with translating ribosomes; putative intrinsically unstructured protein	cytoplasmic translation	molecular_function	polysome|cytoplasm
YOL114C_p	YOL114C	YOL114C	hom	Uncharacterized	3.27647393385985	0.000525560073544892	yes	32	0.000540146479625632	29	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION			Putative protein of unknown function with similarity to human ICT1 and prokaryotic factors that may function in translation termination; YOL114C is not an essential gene	biological_process	molecular_function	cellular_component
YIL085C	YIL085C	KTR7	hom	Verified	3.27633280620182	0.000525822789147751	yes	33	0.000387764461527895	29	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	GOLGI APPARATUS		Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; KTR7 has a paralog, KTR5, that arose from the whole genome duplication	fungal-type cell wall organization|protein N-linked glycosylation	mannosyltransferase activity	Golgi apparatus
YGL038C	YGL038C	OCH1	hom	Verified	3.22686823356113	0.000625765397411675	yes	34	0.00051198053496045	25	NA	FT	CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Mannosyltransferase of the cis-Golgi apparatus, initiates the polymannose outer chain elongation of N-linked oligosaccharides of glycoproteins	protein N-linked glycosylation	alpha-1,6-mannosyltransferase activity|transferase activity, transferring glycosyl groups	Golgi cis cisterna
YPL176C	YPL176C	TRE1	hom	Verified	3.17926698493993	0.000738240135282627	yes	35	0.00306889395214523	80	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEOLYSIS|VACUOLAR TRANSPORT	PLASMA MEMBRANE		Transferrin receptor-like protein; plasma membrane protein that binds Bsd2p and regulates ubiquitylation and vacuolar degradation of the metal transporter Smf1p; functionally redundant with Tre2p; TRE1 has a paralog, TRE2, that arose from the whole genome duplication	protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	molecular_function	fungal-type vacuole
YJL190C	YJL190C	RPS22A	hom	Verified	3.14791169377664	0.000822206810631444	yes	36	0.00112478365984075	46	NA	FT	TRANSLATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22A has a paralog, RPS22B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic small ribosomal subunit
YBR168W	YBR168W	PEX32	hom	Verified	3.10480764408121	0.000952014027001247	yes	37	0.00173693636399851	43	NA	FT	PEROXISOME ORGANIZATION			Peroxisomal integral membrane protein, involved in negative regulation of peroxisome size; partially functionally redundant with Pex31p; genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p	peroxisome organization	molecular_function	integral to membrane|integral to peroxisomal membrane
YBL007C	YBL007C	SLA1	hom	Verified	3.09459920726831	0.000985395063751581	yes	38	0.00634827200651681	107	NA	FF|FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION	NUCLEUS|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON		Cytoskeletal protein binding protein required for assembly of the cortical actin cytoskeleton; interacts with proteins regulating actin dynamics and proteins required for endocytosis; found in the nucleus and cell cortex; has 3 SH3 domains	fungal-type cell wall organization|endocytosis|actin cortical patch assembly	ubiquitin binding|protein binding, bridging	cell cortex|nucleus|mating projection tip|actin cortical patch
YDR506C	YDR506C	GMC1	hom	Verified	3.0810237662425	0.00103145091164021	no	39	0.000518142851780501	25	NA	FT	CELL CYCLE|ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS			Protein involved in meiotic progression; mutants are delayed in meiotic nuclear division and are defective in synaptonemal complex assembly; possible membrane-localized protein	meiosis|synaptonemal complex organization	molecular_function	cellular_component
YGL119W	YGL119W	COQ8	hom	Verified	3.06891453374476	0.00107419021484134	no	40	0.00203892847117268	58	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication	ubiquinone biosynthetic process|aerobic respiration	molecular_function	mitochondrion|extrinsic to mitochondrial inner membrane|mitochondrial matrix
YBL071C-B_p	YBL071C-B	YBL071C-B	hom	Uncharacterized	3.05499591979602	0.00112531791989926	no	41	0.00203354497814231	47	NA					Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching	biological_process	molecular_function	cellular_component
YBR018C	YBR018C	GAL7	hom	Verified	3.0520115871063	0.00113656662945439	no	42	0.000721628231838967	36	NA	FT	CARBOHYDRATE METABOLISM			Galactose-1-phosphate uridyl transferase, synthesizes glucose-1-phosphate and UDP-galactose from UDP-D-glucose and alpha-D-galactose-1-phosphate in the second step of galactose catabolism	galactose catabolic process via UDP-galactose	UDP-glucose:hexose-1-phosphate uridylyltransferase activity	cytoplasm
YIL065C	YIL065C	FIS1	hom	Verified	3.05074767733365	0.00114136160390405	no	43	0.000911678020538197	53	NA	FT	MITOCHONDRION ORGANIZATION|PEROXISOME ORGANIZATION	MITOCHONDRION		Protein involved in mitochondrial membrane fission and peroxisome abundance; required for localization of Dnm1p and Mdv1p during mitochondrial division; mediates ethanol-induced apoptosis and ethanol-induced mitochondrial fragmentation	peroxisome fission|mitochondrial fission|chronological cell aging|peroxisome organization	molecular_function	mitochondrial outer membrane|mitochondrion|peroxisome
YNR001C	YNR001C	CIT1	hom	Verified	3.04447537003896	0.0011654325753105	no	44	0.00162547537722122	53	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Citrate synthase; catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate; the rate-limiting enzyme of the TCA cycle; nuclear encoded mitochondrial protein; CIT1 has a paralog, CIT2, that arose from the whole genome duplication	glutamate biosynthetic process|tricarboxylic acid cycle|acetyl-CoA catabolic process|citrate metabolic process	citrate (Si)-synthase activity	mitochondrion
YPL091W	YPL091W	GLR1	hom	Verified	2.99968606887583	0.00135128998212332	no	45	0.00257556291845745	82	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS	NUCLEUS|MITOCHONDRION		Cytosolic and mitochondrial glutathione oxidoreductase; converts oxidized glutathione to reduced glutathione; mitochondrial but not cytosolic form has a role in resistance to hyperoxia; protein abundance increases in response to DNA replication stress	cellular response to oxidative stress|protein glutathionylation	glutathione-disulfide reductase activity	mitochondrion|nucleus|cytoplasm
YGL023C	YGL023C	PIB2	hom	Verified	2.99133159897525	0.00138881846015708	no	46	0.0019007956861047	41	NA	FT	VESICLE-MEDIATED TRANSPORT	MITOCHONDRION		Protein of unknown function; contains FYVE domain; similar to Fab1 and Vps27	biological_process	molecular_function	mitochondrion
YJL073W	YJL073W	JEM1	hom	Verified	2.97413130891699	0.00146909656122707	no	47	0.00189996962919057	74	NA	FT	PROTEOLYSIS	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM		DnaJ-like chaperone required for nuclear membrane fusion during mating, localizes to the ER membrane; exhibits genetic interactions with KAR2	karyogamy involved in conjugation with cellular fusion|ER-associated protein catabolic process|protein folding in endoplasmic reticulum	unfolded protein binding|chaperone binding	endoplasmic reticulum|nuclear outer membrane-endoplasmic reticulum membrane network
YNL097C	YNL097C	PHO23	hom	Verified	2.95514657753761	0.00156260266601496	no	48	0.00140767643030752	62	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS|CHROMOSOME		Probable component of the Rpd3 histone deacetylase complex, involved in transcriptional regulation of PHO5; affects termination of snoRNAs and cryptic unstable transcripts (CUTs); C-terminus has similarity to human candidate tumor suppressor p33(ING1) and its isoform ING3	positive regulation of transcription from RNA polymerase II promoter in response to heat stress|negative regulation of chromatin silencing at silent mating-type cassette|negative regulation of transcription from RNA polymerase I promoter|negative regulation of chromatin silencing at telomere|negative regulation of chromatin silencing at rDNA|chromatin modification|positive regulation of transcription from RNA polymerase II promoter	methylated histone residue binding	histone deacetylase complex|Rpd3L-Expanded complex|nucleus|Rpd3L complex
YHR175W-A_p	YHR175W-A	YHR175W-A	hom	Uncharacterized	2.9393888248884	0.00164430113745457	no	49	0.000625124396364625	25	NA					Putative protein of unknown function; identified by fungal homology and RT-PCR	biological_process	molecular_function	cellular_component
YFL010W-A	YFL010W-A	AUA1	hom	Verified	2.93139199863797	0.00168723338994443	no	50	0.00241290254047239	47	NA					Protein required for the negative regulation by ammonia of Gap1p, which is a general amino acid permease	amino acid transport	molecular_function	cellular_component
YJR020W_d	YJR020W	YJR020W	hom	Dubious	2.91696383549081	0.00176728376014212	no	51	0.000759327874147561	27	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YER161C	YER161C	SPT2	hom	Verified	2.89944305039334	0.00186913123957225	no	52	0.0047127502072224	75	NA	FT	TRANSCRIPTION FROM RNA POL II|RNA PROCESSING|CHROMATIN ORGANIZATION	NUCLEUS		Protein involved in negative regulation of transcription; required for RNA polyadenylation; exhibits regulated interactions with both histones and SWI-SNF components, has similarity to mammalian HMG1 proteins	negative regulation of transcription from RNA polymerase II promoter|chromatin organization|RNA polyadenylation|transcription elongation from RNA polymerase II promoter	DNA binding|DNA secondary structure binding	nucleus
YKL007W	YKL007W	CAP1	hom	Verified	2.89646265162456	0.0018869778076858	no	53	0.00218495100838296	73	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Alpha subunit of the capping protein heterodimer (Cap1p and Cap2p); capping protein (CP) binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches; protein increases in abundance and relocalizes from bud neck to plasma membrane upon DNA replication stress	barbed-end actin filament capping	actin filament binding	actin filament|F-actin capping protein complex|mating projection tip|actin cortical patch
YCR087C-A_p	YCR087C-A	YCR087C-A	hom	Uncharacterized	2.88175954917797	0.00197730693493897	no	54	0.00293765406223309	88	NA	FT		NUCLEUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; YCR087C-A is not an essential gene	biological_process	molecular_function	nucleolus
YPR032W	YPR032W	SRO7	hom	Verified	2.8770038926856	0.00200735321371432	no	55	0.00249349007550418	77	NA	FT	VESICLE-MEDIATED TRANSPORT|SIGNALING	PLASMA MEMBRANE		Effector of Rab GTPase Sec4p; forms a complex with Sec4p and t-SNARE Sec9p; involved in exocytosis and docking and fusion of post-Golgi vesicles with plasma membrane; homolog of Drosophila lgl tumor suppressor; SRO7 has a paralog, SRO77, that arose from the whole genome duplication	establishment of cell polarity|exocytosis|Golgi to plasma membrane transport|small GTPase mediated signal transduction	SNARE binding|Rab GTPase binding	cytosol|plasma membrane
YDL032W_d	YDL032W	YDL032W	hom	Dubious	2.84567477796378	0.00221587157441149	no	56	0.00426033613118534	95	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene SLM3/YDL033C; YDL032W is not an essential gene	Unknown	Unknown	Unknown
YDR015C_d	YDR015C	YDR015C	hom	Dubious	2.84316291546877	0.00223341157165805	no	57	0.00128065630143815	34	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene HED1/YDR014W-A	Unknown	Unknown	Unknown
YJL185C	YJL185C	ATG36	hom	Verified	2.77899016929238	0.00272640876522351	no	58	0.00189988859940637	49	NA					Pex3p interacting protein, required for pexophagy; interacts with Atg8p and Atg11p; mRNA is weakly cell cycle regulated, peaking in G2 phase; YJL185C is a non-essential gene	peroxisome degradation	molecular_function	peroxisome
YBR022W	YBR022W	POA1	hom	Verified	2.76001345917971	0.00288994901241809	no	59	0.00134698568224712	53	NA	FT	RNA PROCESSING			Phosphatase that is highly specific for ADP-ribose 1''-phosphate, a tRNA splicing metabolite; may have a role in regulation of tRNA splicing	tRNA splicing, via endonucleolytic cleavage and ligation	phosphatase activity	cellular_component
YBL075C	YBL075C	SSA3	hom	Verified	2.74355494067584	0.00303889384224875	no	60	0.00390651348517697	104	NA	FT	PROTEIN LOCALIZATION			ATPase involved in protein folding and the response to stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasm; SSA3 has a paralog, SSA4, that arose from the whole genome duplication	protein folding|SRP-dependent cotranslational protein targeting to membrane, translocation|response to stress	unfolded protein binding|ATPase activity	cytosol
YCL008C	YCL008C	STP22	hom	Verified	2.73684459444399	0.0031015794652602	no	61	0.00772210688055023	144	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEOLYSIS|VACUOLAR TRANSPORT	PLASMA MEMBRANE		Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; homologous to the mouse and human Tsg101 tumor susceptibility gene; mutants exhibit a Class E Vps phenotype	protein targeting to membrane|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|late endosome to vacuole transport|protein targeting to vacuole	ubiquitin binding	endosome|ESCRT I complex|internal side of plasma membrane
YGL031C	YGL031C	RPL24A	hom	Verified	2.72731538896533	0.00319259880482685	no	62	0.00415715057308942	72	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L24A; not essential for translation but may be required for normal translation rate; homologous to mammalian ribosomal protein L24, no bacterial homolog; RPL24A has a paralog, RPL24B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome|RNA binding	cytosolic large ribosomal subunit
YIL103W	YIL103W	DPH1	hom	Verified	2.72347690072573	0.00322993664223477	no	63	0.00449143704514294	69	NA					Protein required, along with Dph2p, Kti11p, Jjj3p, and Dph5p, for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); may act in a complex with Dph2p and Kti11p	peptidyl-diphthamide biosynthetic process from peptidyl-histidine	molecular_function	cytoplasm
YOL095C	YOL095C	HMI1	hom	Verified	2.71575235576643	0.00330626798987721	no	64	0.00711765822499573	106	NA	FT	RESPONSE TO DNA DAMAGE|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial inner membrane localized ATP-dependent DNA helicase, required for the maintenance of the mitochondrial genome; not required for mitochondrial transcription; has homology to E. coli helicase uvrD	mitochondrial genome maintenance|mitochondrial DNA metabolic process	ATP-dependent 3'-5' DNA helicase activity	mitochondrion|mitochondrial matrix
YAL053W	YAL053W	FLC2	hom	Verified	2.71571344616648	0.00330665655281432	no	65	0.00629731782026969	84	NA	FT	CELL WALL ORG/BIOGENESIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance; FLC2 has a paralog, YOR365C, that arose from the whole genome duplication	protein folding|fungal-type cell wall biogenesis|FAD transport|transmembrane transport	FAD transmembrane transporter activity	integral to membrane|endoplasmic reticulum|cytoplasm
YPL222W_p	YPL222W	FMP40	hom	Uncharacterized	2.6867194228968	0.00360787684925852	no	66	0.00350310866299545	66	NA	FT		MITOCHONDRION		Putative protein of unknown function; proposed to be involved in responding to environmental stresses; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YER014W	YER014W	HEM14	hom	Verified	2.68509299025282	0.00362548145239821	no	67	0.00819725727834016	83	NA	FT	OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM	MITOCHONDRION		Protoporphyrinogen oxidase, a mitochondrial enzyme that catalyzes the seventh step in the heme biosynthetic pathway, converting protoporphyrinogen IX to protoporphyrin IX; inhibited by diphenyl ether-type herbicides	heme biosynthetic process	oxygen-dependent protoporphyrinogen oxidase activity	mitochondrion|mitochondrial inner membrane
YCR098C	YCR098C	GIT1	hom	Verified	2.66323482511073	0.00386966921138097	no	68	0.00420237852321437	96	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Plasma membrane permease, mediates uptake of glycerophosphoinositol and glycerophosphocholine as sources of the nutrients inositol and phosphate; expression and transport rate are regulated by phosphate and inositol availability	transmembrane transport|glycerophosphodiester transport	glycerophosphodiester transmembrane transporter activity	integral to membrane|plasma membrane
YPR200C	YPR200C	ARR2	hom	Verified	2.65649316631918	0.00394790256068333	no	69	0.00218643624321598	45	NA					Arsenate reductase required for arsenate resistance; converts arsenate to arsenite which can then be exported from cells by Arr3p	response to arsenic-containing substance	arsenate reductase activity	cellular_component
YCL005W-A	YCL005W-A	VMA9	hom	Verified	2.65102161080566	0.00401243532651808	no	70	0.00866598431874177	106	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|CELL WALL ORG/BIOGENESIS|ION HOMEOSTASIS			Vacuolar H+ ATPase subunit e of the V-ATPase V0 subcomplex; essential for vacuolar acidification; interacts with the V-ATPase assembly factor Vma21p in the ER; involved in V0 biogenesis	cell wall mannoprotein biosynthetic process|vacuolar acidification|protein complex assembly|transmembrane transport	ATPase activity, coupled to transmembrane movement of ions	vacuolar proton-transporting V-type ATPase, V0 domain|fungal-type vacuole membrane
YDR025W	YDR025W	RPS11A	hom	Verified	2.64601692036759	0.0040722871221054	no	71	0.00492288828687104	71	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S11 and bacterial S17; RPS11A has a paralog, RPS11B, that arose from the whole genome duplication	cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|ribosomal small subunit assembly	structural constituent of ribosome	cytosolic small ribosomal subunit|90S preribosome
YNL271C	YNL271C	BNI1	hom	Verified	2.6359501254474	0.00419510313017403	no	72	0.0156988223318287	148	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON		Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNR1	barbed-end actin filament capping|actin nucleation|actin filament bundle assembly involved in cytokinetic actomyosin contractile ring assembly|establishment of mitotic spindle orientation|formin-nucleated actin cable assembly	profilin binding	incipient cellular bud site|actin filament|polarisome|plasma membrane|cellular bud neck|mating projection tip|cellular bud tip
YCR023C	YCR023C	YCR023C	hom	Verified	2.62844898777696	0.00428876096539194	no	73	0.00326764668909819	71	NA					Vacuolar membrane protein of unknown function; member of the multidrug resistance family; YCR023C is not an essential gene	biological_process	molecular_function	fungal-type vacuole membrane|integral to membrane
YDR218C	YDR218C	SPR28	hom	Verified	2.59286392700255	0.00475902103729081	no	74	0.00196230230060642	41	NA	FT	CELL CYCLE|CELL DIVISION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Sporulation-specific homolog of the yeast CDC3/10/11/12 family of bud neck microfilament genes; meiotic septin expressed at high levels during meiotic divisions and ascospore formation	sexual sporulation resulting in formation of a cellular spore	structural molecule activity	spindle microtubule|meiotic spindle|septin complex|prospore membrane|ascospore wall
YER097W_d	YER097W	YER097W	hom	Dubious	2.57731346253872	0.00497858041924256	no	75	0.0100668684893841	108	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YMR310C_p	YMR310C	YMR310C	hom	Uncharacterized	2.57724150078975	0.00497961709226956	no	76	0.00707225693552338	73	NA	FT		NUCLEUS		Putative S-adenosylmethionine-dependent methyltransferase; predicted to be involved in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR310C is not an essential gene	biological_process	S-adenosylmethionine-dependent methyltransferase activity	nucleus
YJL099W	YJL099W	CHS6	hom	Verified	2.5756735837105	0.00500225212047956	no	77	0.00862824079485294	115	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	GOLGI APPARATUS		Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; CHS6 has a paralog, BCH2, that arose from the whole genome duplication	Golgi to plasma membrane transport|fungal-type cell wall chitin biosynthetic process	molecular_function	trans-Golgi network transport vesicle|clathrin-coated vesicle|exomer complex
YPR158W	YPR158W	CUR1	hom	Verified	2.57261907953464	0.00504661138332941	no	78	0.00679805351463699	105	NA	FT		NUCLEUS		Sorting factor, central regulator of spatial protein quality control; physically and functionally interacts with chaperones to promote sorting and deposition of misfolded proteins into cytosolic compartments; involved in destabilization of [URE3] prions; CUR1 has a paralog, BTN2, that arose from the whole genome duplication	cellular response to stress|protein localization to nucleus	chaperone binding	nucleus
YOR131C	YOR131C	YOR131C	hom	Verified	2.56788155005487	0.00511610566292522	no	79	0.0078584589640561	82	NA	FT		NUCLEUS		Putative haloacid dehalogenase-like hydrolase; non-essential gene; overexpression causes a cell cycle delay or arrest; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	nucleus|cytoplasm
YLR399C	YLR399C	BDF1	hom	Verified	2.56684052662801	0.00513149000034528	no	80	0.00572967925766143	118	NA	FT	CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING	NUCLEUS|CHROMOSOME		Protein involved in transcription initiation at TATA-containing promoters; associates with the basal transcription factor TFIID; contains two bromodomains; corresponds to the C-terminal region of mammalian TAF1; redundant with Bdf2p	DNA repair|snRNA transcription|regulation of chromatin silencing at telomere|regulation of transcription by chromatin organization|regulation of chromatin silencing at silent mating-type cassette|Unknown|chromatin remodeling|negative regulation of heterochromatin assembly	histone acetyl-lysine binding|chromatin binding|core promoter binding|TFIID-class transcription factor binding	nuclear chromatin|Swr1 complex
YFL013C	YFL013C	IES1	hom	Verified	2.56638958343169	0.00513816685138286	no	81	0.00934549447871114	90	NA	FT	CHROMATIN ORGANIZATION	NUCLEUS|CHROMOSOME		Subunit of the INO80 chromatin remodeling complex	nucleosome mobilization	molecular_function	nucleus|Ino80 complex
YOR022C_p	YOR022C	YOR022C	hom	Uncharacterized	2.55724720159089	0.00527521061645233	no	82	0.00389043894998046	63	NA	FT	LIPID METABOLISM	MITOCHONDRION		Putative carboxylic ester hydrolase; similar to bovine phospholipase A1; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	phospholipase activity	mitochondrion
YBL090W	YBL090W	MRP21	hom	Verified	2.52639489451547	0.00576199326633499	no	83	0.0116891708339294	113	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the small subunit; MRP21 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequences	mitochondrial translational initiation|mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YJL197W	YJL197W	UBP12	hom	Verified	2.52120625250922	0.00584766390053362	no	84	0.00441987613326535	89	NA	FT	PROTEOLYSIS	NUCLEUS		Ubiquitin-specific protease; cleaves ubiquitin from ubiquitinated proteins; present in the nucleus and cytoplasm	biological_process	ubiquitin-specific protease activity	nucleus|cytoplasm
YIL016W	YIL016W	SNL1	hom	Verified	2.51476035274102	0.00595566595703384	no	85	0.00443395866799903	88	NA	FT		ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|MITOCHONDRION		Ribosome-associated protein proposed to act in protein synthesis and nuclear pore complex biogenesis and maintenance as well as protein folding; has similarity to the mammalian BAG-1 protein	protein folding|nuclear pore organization	ribosome binding	nuclear envelope|mitochondrion|cytosolic ribosome|endoplasmic reticulum membrane|membrane
YJL120W_d	YJL120W	YJL120W	hom	Dubious	2.51301343852981	0.00598523874709207	no	86	0.0240769769980771	225	NA	FF				Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL121C/RPE1; deletion confers sensitivity to GSAO	Unknown	Unknown	Unknown
YMR003W	YMR003W	AIM34	hom	Verified	2.49632923601819	0.00627430357111197	no	87	0.00481403351569417	57	NA	FT		MITOCHONDRION		Protein of unknown function; GFP-fusion protein localizes to the mitochondria; null mutant is viable and displays reduced frequency of mitochondrial genome loss	biological_process	molecular_function	mitochondrion
YDR291W	YDR291W	HRQ1	hom	Verified	2.48075972148819	0.00655513572918011	no	88	0.00458628898659273	64	NA	FT		NUCLEUS		3'-5'DNA helicase that has DNA strand annealing activity; helicase activity is stimulated by fork structure and 3'-tail length of substrates; belongs to the widely conserved RecQ family of proteins which are involved in maintaining genomic integrity; similar to the human RecQ4p implicated in Rothmund-Thomson syndrome(RTS)	biological_process	molecular_function	nucleus
YGL100W	YGL100W	SEH1	hom	Verified	2.4771279885463	0.00662221990484277	no	89	0.0122166306860517	146	NA	FF|FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS|PLASMA MEMBRANE	NUCLEAR PORE	Component of two distinct complexes; subunit of the Nup84 nuclear pore sub-complex (NPC) and the Seh1-associated (SEA) complex; the the NUP84 subcomplex contributes to nucleocytoplasmic transport and NPC biogenesis; the SEA complex is a coatamer-related complex that associates dynamically with the vacuole; homologous to human SEH1	nucleocytoplasmic transport	structural constituent of nuclear pore	fungal-type vacuole membrane|integral to membrane|nuclear pore|Seh1-associated complex|nuclear pore outer ring
YGR290W_d	YGR290W	YGR290W	hom	Dubious	2.46686409163785	0.00681510401659435	no	90	0.00798306237001114	110	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; putative HLH protein; partially overlaps the verified ORF MAL11/YGR289C (a high-affinity maltose transporter)	Unknown	Unknown	Unknown
YNL148C	YNL148C	ALF1	hom	Verified	2.4655041747617	0.00684102903918152	no	91	0.0235834408412887	240	NA	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS	NUCLEUS|CYTOSKELETON		Alpha-tubulin folding protein, similar to mammalian cofactor B; Alf1p-GFP localizes to cytoplasmic microtubules; required for the folding of alpha-tubulin and may play an additional role in microtubule maintenance	protein folding|post-chaperonin tubulin folding pathway	microtubule binding|alpha-tubulin binding	nucleus|cytoplasm
YHR010W	YHR010W	RPL27A	hom	Verified	2.44754829637368	0.00719159236116258	no	92	0.00522208274770011	99	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L27A; homologous to mammalian ribosomal protein L27, no bacterial homolog; RPL27A has a paralog, RPL27B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YPR024W	YPR024W	YME1	hom	Verified	2.44253190482924	0.00729232020638173	no	93	0.00436513170474669	90	NA	FT	PROTEOLYSIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Catalytic subunit of the mitochondrial inner membrane i-AAA protease complex, which is responsible for degradation of unfolded or misfolded mitochondrial gene products; also has a role in intermembrane space protein folding; mutation causes an elevated rate of mitochondrial turnover	chronological cell aging|misfolded or incompletely synthesized protein catabolic process|mitochondrion organization	ATP-dependent peptidase activity	mitochondrion|mitochondrial inner membrane|i-AAA complex
YDL161W	YDL161W	ENT1	hom	Verified	2.44001470600686	0.00734333201177283	no	94	0.00319233566839337	46	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Epsin-like protein involved in endocytosis and actin patch assembly; functionally redundant with Ent2p; binds clathrin via a clathrin-binding domain motif at C-terminus; relocalizes from bud neck to cytoplasm upon DNA replication stress	actin filament organization|endocytosis|actin cortical patch assembly	clathrin binding	mating projection tip|actin cortical patch
YPR005C	YPR005C	HAL1	hom	Verified	2.43607121245577	0.00742388057177087	no	95	0.0112458338535391	99	NA	FT	TRANSCRIPTION FROM RNA POL II			Cytoplasmic protein involved in halotolerance; decreases intracellular Na+ (via Ena1p) and increases intracellular K+ by decreasing efflux; expression repressed by Ssn6p-Tup1p and Sko1p and induced by NaCl, KCl, and sorbitol through Gcn4p	response to salt stress|positive regulation of transcription from RNA polymerase II promoter	molecular_function	cytoplasm
YJR004C	YJR004C	SAG1	hom	Verified	2.43402592839982	0.00746596271575471	no	96	0.00716307979114131	58	NA					Alpha-agglutinin of alpha-cells, binds to Aga1p during agglutination, N-terminal half is homologous to the immunoglobulin superfamily and contains binding site for a-agglutinin, C-terminal half is highly glycosylated and contains GPI anchor	agglutination involved in conjugation with cellular fusion	cell adhesion molecule binding	fungal-type cell wall
YNL135C	YNL135C	FPR1	hom	Verified	2.42468253531513	0.00766088931142354	no	97	0.0116623156147968	105	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|CHROMATIN ORGANIZATION	NUCLEUS|MITOCHONDRION		Peptidyl-prolyl cis-trans isomerase (PPIase), binds to the drugs FK506 and rapamycin; also binds to the nonhistone chromatin binding protein Hmo1p and may regulate its assembly or function	protein folding|chromatin organization|homoserine metabolic process	peptidyl-prolyl cis-trans isomerase activity|macrolide binding	mitochondrion|nucleus|cytoplasm
YLR268W	YLR268W	SEC22	hom	Verified	2.41354763748342	0.0078990312881172	no	98	0.0328435734555265	254	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		R-SNARE protein; assembles into SNARE complex with Bet1p, Bos1p and Sed5p; cycles between the ER and Golgi complex; involved in anterograde and retrograde transport between the ER and Golgi; synaptobrevin homolog	retrograde vesicle-mediated transport, Golgi to ER|ER to Golgi vesicle-mediated transport|vesicle fusion with Golgi apparatus|vesicle fusion with endoplasmic reticulum|vesicle fusion	SNAP receptor activity	SNARE complex|integral to membrane|Golgi apparatus|endoplasmic reticulum|ER to Golgi transport vesicle membrane
YPL040C	YPL040C	ISM1	hom	Verified	2.41066696635177	0.00796169051158046	no	99	0.0170612407109525	131	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth	isoleucyl-tRNA aminoacylation|mitochondrial isoleucyl-tRNA aminoacylation|mitochondrial translation	isoleucine-tRNA ligase activity	mitochondrion
YIL087C	YIL087C	AIM19	hom	Verified	2.40943222112478	0.00798868174658784	no	100	0.00550857374269309	64	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays reduced respiratory growth	biological_process	molecular_function	mitochondrion
YIL170W	YIL170W	HXT12	hom	pseudogene	2.39846286941932	0.00823202280227256	no	101	0.00585350501275573	88	NA					Possible pseudogene in strain S288C; YIL170W/HXT12 and the adjacent ORF, YIL171W, together encode a non-functional member of the hexose transporter family	hexose transport|biological_process	hexose transmembrane transporter activity|molecular_function	integral to membrane
YBR068C	YBR068C	BAP2	hom	Verified	2.39758978305157	0.00825166796173339	no	102	0.00523330757576706	99	NA	FT		PLASMA MEMBRANE		High-affinity leucine permease; functions as a branched-chain amino acid permease involved in uptake of leucine, isoleucine and valine; contains 12 predicted transmembrane domains; BAP2 has a paralog, BAP3, that arose from the whole genome duplication	amino acid transport|transmembrane transport	amino acid transmembrane transporter activity	integral to membrane|plasma membrane
YML128C	YML128C	MSC1	hom	Verified	2.39481220414804	0.00831443991184542	no	103	0.0113092836148474	118	NA	FT	CELL CYCLE	ENDOPLASMIC RETICULUM|MITOCHONDRION		Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria and is phosphorylated	reciprocal meiotic recombination	molecular_function	mitochondrion|endoplasmic reticulum|plasma membrane
YBR082C	YBR082C	UBC4	hom	Verified	2.38892291993894	0.00844892358668221	no	104	0.00636487606144554	75	NA	FT	PROTEOLYSIS			Ubiquitin-conjugating enzyme (E2); mediates degradation of abnormal or excess proteins, including calmodulin and histone H3; interacts with many SCF ubiquitin protein ligases; component of the cellular stress response; UBC4 has a paralog, UBC5, that arose from the whole genome duplication	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|protein monoubiquitination|protein polyubiquitination|protein ubiquitination|response to stress	ubiquitin binding|ubiquitin-protein ligase activity	proteasome complex
YDR485C	YDR485C	VPS72	hom	Verified	2.38367681504399	0.00857032402348905	no	105	0.0265784525753253	230	NA	FF|FT	CHROMATIN ORGANIZATION	NUCLEUS|CHROMOSOME		Htz1p-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting	chromatin remodeling|histone exchange	histone binding	Swr1 complex|nucleus|cytoplasm
YLR063W_p	YLR063W	YLR063W	hom	Uncharacterized	2.38355296123148	0.00857320852887241	no	106	0.0060660865133443	45	NA					Putative S-adenosylmethionine-dependent methyltransferase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR063W is not an essential gene	biological_process	S-adenosylmethionine-dependent methyltransferase activity	cytoplasm
YPR123C_d	YPR123C	YPR123C	hom	Dubious	2.37606595363826	0.00874916740485278	no	107	0.0613786331666491	335	NA	FF				Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially/completely overlaps the verified ORF CTR	Unknown	Unknown	Unknown
YKL160W	YKL160W	ELF1	hom	Verified	2.36216124429332	0.00908436891257275	no	108	0.00817121512054173	94	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION	NUCLEUS		Transcription elongation factor that contains a conserved zinc finger domain; implicated in the maintenance of proper chromatin structure in actively transcribed regions; deletion inhibits Brome mosaic virus (BMV) gene expression	regulation of transcription by chromatin organization|transcription elongation from RNA polymerase II promoter	RNA polymerase II core binding	transcription elongation factor complex|nucleus
YIL093C	YIL093C	RSM25	hom	Verified	2.35846724539142	0.00917528957293329	no	109	0.0161916377601964	157	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the small subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YNL264C	YNL264C	PDR17	hom	Verified	2.35525334493358	0.0092550405326795	no	110	0.00986784858671787	92	NA	FT	LIPID METABOLISM			Phosphatidylinositol transfer protein (PITP), downregulates Plb1p-mediated turnover of phosphatidylcholine, found in the cytosol and microsomes, homologous to Pdr16p, deletion affects phospholipid composition	Golgi to plasma membrane protein transport|phosphatidylserine metabolic process|response to drug|sterol biosynthetic process|Unknown|phospholipid transport|phospholipid biosynthetic process	phosphatidylinositol transporter activity|phosphatidylcholine transporter activity	endosome|cell periphery|cytosol|cytoplasm
YMR090W_p	YMR090W	YMR090W	hom	Uncharacterized	2.3377432961298	0.00970028436000249	no	111	0.0128601309964166	117	NA					Putative protein of unknown function with similarity to DTDP-glucose 4,6-dehydratases; GFP-fusion protein localizes to the cytoplasm; up-regulated in response to the fungicide mancozeb; not essential for viability	biological_process	molecular_function	cytoplasm
YGR104C	YGR104C	SRB5	hom	Verified	2.33386048423817	0.00980151423444682	no	112	0.0116408471736556	127	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS	RNA POL II, HOLOENZYME	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; required for proper termination of transcription for some genes; involved in telomere maintenance	transcriptional open complex formation at RNA polymerase II promoter|RNA polymerase II transcriptional preinitiation complex assembly|positive regulation of transcription from RNA polymerase II promoter	core RNA polymerase II binding transcription factor activity|RNA polymerase II transcription factor recruiting transcription factor activity|TBP-class protein binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly	core mediator complex
YJL210W	YJL210W	PEX2	hom	Verified	2.33140970824572	0.00986588305205076	no	113	0.00764421174246593	71	NA	FT	PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION			RING-finger peroxin and E3 ubiquitin ligase, peroxisomal membrane protein with a C-terminal zinc-binding RING domain, forms translocation subcomplex with Pex10p and Pex12p which functions in peroxisomal matrix protein import	protein import into peroxisome matrix	ubiquitin-protein ligase activity|protein binding	peroxisomal membrane
YDL233W_p	YDL233W	MFG1	hom	Uncharacterized	2.32635347828678	0.00999985063581393	no	114	0.00713510655552562	79	NA	FT		NUCLEUS		Regulator of filamentous growth; interacts with FLO11 promoter and regulates FLO11 expression; binds to transcription factors Flo8p and Mss11p; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YDL233W is not an essential gene	biological_process	molecular_function	nucleus|cytoplasm
YOL041C	YOL041C	NOP12	hom	Verified	2.32315569245084	0.0100853950175049	no	115	0.0138338300437848	129	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Nucleolar protein involved in pre-25S rRNA processing and biogenesis of large 60S ribosomal subunit; contains an RNA recognition motif (RRM); binds to Ebp2; similar to Nop13p and Nsr1p	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	RNA binding	nucleolus|preribosome
YGL190C	YGL190C	CDC55	hom	Verified	2.31807444032161	0.0102226378742677	no	116	0.0168730076309184	145	NA	FT	CELL CYCLE|SIGNALING	NUCLEUS|SITE OF POLARIZED GROWTH		Non-essential regulatory subunit B of protein phosphatase 2A (PP2A); localization to the cytoplasm requires Zds1p and Zds2p and promotes mitotic entry; localization to the nucleus prevents mitotic exit; required for correct nuclear division and chromosome segregation in meiosis; maintains nucleolar sequestration of Cdc14p during early meiosis; limits formation of PP2A-Rts1p holocomplexes to ensure timely dissolution of sister chromosome cohesion	negative regulation of exit from mitosis|positive regulation of G2/M transition of mitotic cell cycle|cell shape checkpoint|protein dephosphorylation	protein phosphatase type 2A regulator activity	nucleus|cellular bud neck|cytoplasm|cellular bud tip
YJL183W	YJL183W	MNN11	hom	Verified	2.31302548064126	0.0103606191216135	no	117	0.0217150342645837	175	NA	FT	CARBOHYDRATE METABOLISM	GOLGI APPARATUS		Subunit of a Golgi mannosyltransferase complex that also contains Anp1p, Mnn9p, Mnn10p, and Hoc1p, and mediates elongation of the polysaccharide mannan backbone; has homology to Mnn10p	protein glycosylation	alpha-1,6-mannosyltransferase activity	alpha-1,6-mannosyltransferase complex
YHR209W	YHR209W	CRG1	hom	Verified	2.30825501055194	0.0104924785658859	no	118	0.0105741796808486	124	NA					S-AdoMet-dependent methyltransferase involved in lipid homeostasis; mediates resistance to a drug cantharidin	lipid homeostasis	mRNA binding|S-adenosylmethionine-dependent methyltransferase activity|methyltransferase activity	cellular_component
YKL065C	YKL065C	YET1	hom	Verified	2.30492202900547	0.0105854703092729	no	119	0.00548211900217317	69	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Endoplasmic reticulum transmembrane protein; may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein	biological_process	molecular_function	ribosome|integral to membrane|endoplasmic reticulum|endoplasmic reticulum membrane
YMR285C	YMR285C	NGL2	hom	Verified	2.30288475789939	0.0106426639826428	no	120	0.00547826324597324	75	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Protein involved in 5.8S rRNA processing; Ccr4p-like RNase required for correct 3'-end formation of 5.8S rRNA at site E; similar to Ngl1p; NGL2 has a paralog, NGL3, that arose from the whole genome duplication	rRNA processing	endoribonuclease activity	intracellular
YOR177C	YOR177C	MPC54	hom	Verified	2.30146763561951	0.01068260635551	no	121	0.0127334489376744	121	NA	FT	VESICLE-MEDIATED TRANSPORT|CELL CYCLE|CELL WALL ORG/BIOGENESIS|CELL DIVISION	NUCLEUS|CYTOSKELETON		Component of the meiotic outer plaque, a membrane-organizing center which is assembled on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane; potential Cdc28p substrate	ascospore wall assembly|vesicle docking	structural molecule activity	spindle pole body
YDR363W-A	YDR363W-A	SEM1	hom	Verified	2.27395572624328	0.0114843243089656	no	122	0.0118676539700823	120	NA	FT	VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|PROTEOLYSIS|RNA LOCALIZATION	NUCLEUS		Component of lid subcomplex of the 26S proteasome regulatory subunit; involved in mRNA export mediated by the TREX-2 complex (Sac3p-Thp1p); ortholog of human DSS1; protein abundance increases in response to DNA replication stress	proteasome assembly|proteasomal ubiquitin-dependent protein catabolic process|regulation of cell cycle|mRNA export from nucleus|exocytosis|filamentous growth|ubiquitin-dependent protein catabolic process	molecular_function	cytosol|nucleus|proteasome storage granule|proteasome regulatory particle, lid subcomplex
YIL011W	YIL011W	TIR3	hom	Verified	2.27129890226491	0.0115644448234567	no	123	0.00783055445704015	85	NA					Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expressed under anaerobic conditions and required for anaerobic growth	biological_process	molecular_function	fungal-type cell wall
YNL095C_p	YNL095C	YNL095C	hom	Uncharacterized	2.26750636370718	0.0116796552988926	no	124	0.0105087444340273	112	NA					Putative protein of unknown function; predicted to contain a transmembrane domain; not an essential gene; YNL095C has a paralog, ECM3, that arose from the whole genome duplication	biological_process	molecular_function	integral to membrane
YOR069W	YOR069W	VPS5	hom	Verified	2.24578614875225	0.012358854471235	no	125	0.0172557080975428	127	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Nexin-1 homolog required for localizing membrane proteins from a prevacuolar/late endosomal compartment back to the late Golgi apparatus; structural component of the retromer membrane coat complex; forms a retromer subcomplex with Vps17p; required for recruiting the retromer complex to the endosome membranes	protein retention in Golgi apparatus|retrograde transport, endosome to Golgi	protein transporter activity|phosphatidylinositol-3-phosphate binding	cytosol|endosome|retromer complex, outer shell|retromer complex
YMR297W	YMR297W	PRC1	hom	Verified	2.24516875227948	0.0123786506403437	no	126	0.00513515429252987	55	NA	FT	PROTEOLYSIS	ENDOPLASMIC RETICULUM		Vacuolar carboxypeptidase Y (proteinase C; CPY), broad-specificity C-terminal exopeptidase involved in non-specific protein degradation in the vacuole; member of the serine carboxypeptidase family	vacuolar protein catabolic process|phytochelatin biosynthetic process	serine-type carboxypeptidase activity	fungal-type vacuole lumen|endoplasmic reticulum|fungal-type vacuole|cytoplasm
YDL194W	YDL194W	SNF3	hom	Verified	2.21112868312343	0.0135134635980535	no	127	0.0109578343920115	109	NA	FT	CELL CYCLE|SIGNALING	PLASMA MEMBRANE		Plasma membrane low glucose sensor, regulates glucose transport; contains 12 predicted transmembrane segments and a long C-terminal tail required for induction of hexose transporters; also senses fructose and mannose; SNF3 has a paralog, RGT2, that arose from the whole genome duplication	mannose transport|glucose transport|signal transduction|negative regulation of meiosis|detection of glucose|fructose transport	glucose transmembrane transporter activity|receptor activity|glucose binding	integral to membrane|plasma membrane
YDR529C	YDR529C	QCR7	hom	Verified	2.20480463085608	0.0137339034788578	no	128	0.0237680114415268	180	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Subunit 7 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the mitochondrial matrix; N-terminus appears to play a role in complex assembly	mitochondrial electron transport, ubiquinol to cytochrome c|aerobic respiration|mitochondrial respiratory chain complex III assembly	ubiquinol-cytochrome-c reductase activity	mitochondrion|integral to membrane|mitochondrial respiratory chain complex III
YHR112C	YHR112C	YHR112C	hom	Verified	2.19913770268412	0.0139340661893587	no	129	0.0103718112523609	104	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Protein of unknown function; localizes to the cytoplasm and nucleus; overexpression affects protein trafficking through the endocytic pathway	sulfur compound metabolic process	cystathionine beta-lyase activity	nucleus|cytoplasm
YJR063W	YJR063W	RPA12	hom	Verified	2.19569466295356	0.0140569027160904	no	130	0.0244808206717438	208	NA	FF|FT		NUCLEUS		RNA polymerase I subunit A12.2; contains two zinc binding domains, and the N terminal domain is responsible for anchoring to the RNA pol I complex	termination of RNA polymerase I transcription|transcription of nuclear large rRNA transcript from RNA polymerase I promoter	molecular_function	DNA-directed RNA polymerase I complex
YPR122W	YPR122W	AXL1	hom	Verified	2.19348533919498	0.0141362148684764	no	131	0.01076287248762	109	NA	FT	CELL CYCLE|CELL DIVISION|PROTEOLYSIS	SITE OF POLARIZED GROWTH		Haploid specific endoprotease that performs one of two N-terminal cleavages during maturation of a-factor mating pheromone; required for axial budding pattern of haploid cells	peptide pheromone maturation|axial cellular bud site selection	metalloendopeptidase activity	mating projection tip|cellular bud neck
YOR351C	YOR351C	MEK1	hom	Verified	2.18771724892759	0.0143451024138338	no	132	0.00940183749742905	113	NA	FT	CELL CYCLE|PROTEIN PHOSPHORYLATION	NUCLEUS		Meiosis-specific serine/threonine protein kinase, functions in meiotic checkpoint, promotes recombination between homologous chromosomes by suppressing double strand break repair between sister chromatids	meiosis|meiotic recombination checkpoint|protein phosphorylation	protein serine/threonine kinase activity|protein kinase activity	nucleus
YCL048W	YCL048W	SPS22	hom	Verified	2.18576728632499	0.0144163176414575	no	133	0.012281909830157	88	NA	FT	CELL WALL ORG/BIOGENESIS	PLASMA MEMBRANE		Protein of unknown function; SPS22 has a paralog, SPS2, that arose from the whole genome duplication; redundant with Sps2p for the organization of the beta-glucan layer of the spore wall	ascospore wall assembly|fungal-type cell wall organization	molecular_function	plasma membrane
YOR005C	YOR005C	DNL4	hom	Verified	2.17903547632437	0.0146645164342457	no	134	0.0100162053302817	79	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CELL DIVISION	NUCLEUS|CHROMOSOME		DNA ligase required for nonhomologous end-joining (NHEJ), forms stable heterodimer with required cofactor Lif1p, interacts with Nej1p; involved in meiosis, not essential for vegetative growth	double-strand break repair via nonhomologous end joining|replicative cell aging	DNA ligase (ATP) activity	DNA ligase IV complex|nuclear chromatin
YEL017W	YEL017W	GTT3	hom	Verified	2.17623407125635	0.0147688812355909	no	135	0.00952897332220992	117	NA	FT		ENDOMEMBRANE SYSTEM|NUCLEUS		Protein of unknown function with a possible role in glutathione metabolism, as suggested by computational analysis of large-scale protein-protein interaction data; GFP-fusion protein localizes to the nuclear periphery	biological_process	molecular_function	cellular_component
YOR368W	YOR368W	RAD17	hom	Verified	2.17157085660273	0.0149440236098648	no	136	0.0141642437037041	123	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Checkpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints; with Mec3p and Ddc1p, forms a clamp that is loaded onto partial duplex DNA; homolog of human and S. pombe Rad1 and U. maydis Rec1 proteins	double-strand break repair|reciprocal meiotic recombination|DNA damage checkpoint	double-stranded DNA binding	nucleus|checkpoint clamp complex
YDL002C	YDL002C	NHP10	hom	Verified	2.1713177490119	0.0149535807731465	no	137	0.0200137438187456	171	NA	FT	CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Protein related to mammalian high mobility group proteins; preferentially binds DNA ends, protecting them from exonucleatic cleavage; likely component of the chromatin-remodeling complex INO80 complex; proposed to be involved in DNA repair	double-strand break repair|nucleosome mobilization	DNA end binding|loop DNA binding	nucleus|Ino80 complex
YPL002C	YPL002C	SNF8	hom	Verified	2.17064288026086	0.0149790890250288	no	138	0.0265421738205362	234	NA	FF|FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|PROTEOLYSIS|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS			Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; appears to be functionally related to SNF7; involved in glucose derepression	negative regulation of transcription from RNA polymerase II promoter by glucose|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|protein targeting to vacuole	molecular_function	ESCRT II complex
YKR061W	YKR061W	KTR2	hom	Verified	2.16246427285094	0.0152912040325724	no	139	0.00990559942354214	85	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Mannosyltransferase involved in N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; KTR2 has a paralog, YUR1, that arose from the whole genome duplication	cell wall mannoprotein biosynthetic process|protein N-linked glycosylation	mannosyltransferase activity	Golgi apparatus
YAL044W-A_p	YAL044W-A	YAL044W-A	hom	Uncharacterized	2.15893975657264	0.0154274204938219	no	140	0.00717238330511524	60	NA					Putative protein of unknown function; similar to S. pombe uvi31 which is a putative DNA repair protein	biological_process	molecular_function	cellular_component
YOR199W_d	YOR199W	YOR199W	hom	Dubious	2.1546765213665	0.0155935781622275	no	141	0.0227651197331385	116	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YLR214W	YLR214W	FRE1	hom	Verified	2.15080074791442	0.0157459650268451	no	142	0.0101760527995159	77	NA	FT	ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|GEN. OF PRECURSOR METABOLITES AND ENERGY	PLASMA MEMBRANE		Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low copper and iron levels	iron ion transport|copper ion import	ferric-chelate reductase activity	integral to membrane|plasma membrane
YNL041C	YNL041C	COG6	hom	Verified	2.14606421261669	0.0159339279983172	no	143	0.134240967719256	529	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments	intra-Golgi vesicle-mediated transport|CVT pathway	molecular_function	Golgi transport complex
YPR004C	YPR004C	AIM45	hom	Verified	2.14266249718862	0.0160701044146214	no	144	0.0149056892688478	138	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Putative ortholog of mammalian electron transfer flavoprotein complex subunit ETF-alpha; interacts with frataxin, Yfh1p; null mutant displays elevated frequency of mitochondrial genome loss; may have a role in oxidative stress response	biological_process	molecular_function	mitochondrion
YPL081W	YPL081W	RPS9A	hom	Verified	2.1420125123471	0.0160962375896135	no	145	0.0160734876097245	138	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION	NUCLEUS	RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S9 and bacterial S4; RPS9A has a paralog, RPS9B, that arose from the whole genome duplication	cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome|rRNA binding	small-subunit processome|cytosolic small ribosomal subunit|90S preribosome|cytoplasm
YAR042W	YAR042W	SWH1	hom	Verified	2.14114472505215	0.0161311844531083	no	146	0.0117312915722453	130	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Protein similar to mammalian oxysterol-binding protein; contains ankyrin repeats; localizes to the Golgi and the nucleus-vacuole junction	endocytosis|maintenance of cell polarity|exocytosis|sterol transport	lipid binding|oxysterol binding|1-phosphatidylinositol binding|sterol transporter activity	nuclear envelope|endoplasmic reticulum|Golgi trans cisterna|early endosome
YEL022W	YEL022W	GEA2	hom	Verified	2.13983574000817	0.0161840218833178	no	147	0.0358473897820189	205	NA	FT	VESICLE-MEDIATED TRANSPORT|SIGNALING|CYTOSKELETON ORGANIZATION|RESPONSE TO NUTRIENT LEVELS	GOLGI APPARATUS		Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs); involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; GEA2 has a paralog, GEA1, that arose from the whole genome duplication	retrograde vesicle-mediated transport, Golgi to ER|secretory granule organization|ER to Golgi vesicle-mediated transport|macroautophagy|intra-Golgi vesicle-mediated transport|actin cytoskeleton organization	ARF guanyl-nucleotide exchange factor activity	integral to membrane|Golgi cis cisterna|extrinsic to membrane
YJL177W	YJL177W	RPL17B	hom	Verified	2.13976276375488	0.0161869719422267	no	148	0.015849346464605	109	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L17B; homologous to mammalian ribosomal protein L17 and bacterial L22; RPL17B has a paralog, RPL17A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YIR039C	YIR039C	YPS6	hom	Verified	2.13941541835608	0.0162010196665947	no	149	0.0220766982771355	150	NA	FT	CELL WALL ORG/BIOGENESIS|PROTEOLYSIS	PLASMA MEMBRANE		Putative GPI-anchored aspartic protease, member of the yapsin family of proteases involved in cell wall growth and maintenance	fungal-type cell wall organization	aspartic-type endopeptidase activity	fungal-type cell wall
YDR034W-B_p	YDR034W-B	YDR034W-B	hom	Uncharacterized	2.13270533857081	0.0164744528529592	no	150	0.0172202784796401	115	NA					Predicted tail-anchored plasma membrane protein containing a conserved CYSTM module; related proteins in other organisms may be involved in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery	biological_process	molecular_function	cellular_component
YJR104C	YJR104C	SOD1	hom	Verified	2.12632176775248	0.0167382383841752	no	151	0.0852707763944166	415	NA	FF|FT	ION HOMEOSTASIS|CELL WALL ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|RESPONSE TO OXIDATIVE STRESS	NUCLEUS|MITOCHONDRION		Cytosolic copper-zinc superoxide dismutase; some mutations are analogous to those that cause ALS (amyotrophic lateral sclerosis) in humans; protein abundance increases in response to DNA replication stress and in response to prolonged exposure to boric acid	cellular copper ion homeostasis|fungal-type cell wall organization|superoxide metabolic process|cellular zinc ion homeostasis|positive regulation of sequence-specific DNA binding transcription factor activity|age-dependent response to reactive oxygen species involved in chronological cell aging	superoxide dismutase activity	cytosol|mitochondrion|nucleus|mitochondrial intermembrane space
YER169W	YER169W	RPH1	hom	Verified	2.12559944334767	0.0167683130047935	no	152	0.0226072638627963	155	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION	NUCLEUS		JmjC domain-containing histone demethylase; specifically demethylates H3K36 tri- and dimethyl modification states; associates with actively transcribed (RNA polymerase II) regions in vivo and specifically targets H3K36 in its trimethylation state as its substrate; transcriptional repressor of PHR1; Rph1p phosphorylation during DNA damage is under control of the MEC1-RAD53 pathway; RPH1 has a paralog, GIS1, that arose from the whole genome duplication	negative regulation of transcription from RNA polymerase II promoter|histone demethylation	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|sequence-specific DNA binding|histone demethylase activity (H3-K36 specific)|histone demethylase activity (H3-K9 specific)	nucleus
YOR191W	YOR191W	ULS1	hom	Verified	2.12387779554444	0.0168401817833887	no	153	0.0149250696902119	156	NA	FT	CHROMATIN ORGANIZATION	NUCLEUS|MITOCHONDRION		Protein involved in proteolytic control of sumoylated substrates; contains RING finger domain; interacts with SUMO (Smt3p); member of the SWI/SNF family of DNA-dependent ATPases; plays a role in antagonizing silencing during mating-type switching; relocalizes from nucleus to cytoplasm upon DNA replication stress	chromatin assembly or disassembly|mating type switching	SUMO binding|DNA-dependent ATPase activity	mitochondrion|nucleolus|nucleus
YHL011C	YHL011C	PRS3	hom	Verified	2.11518265892904	0.0172071911666236	no	154	0.0252720556790008	225	NA	FF|FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM			5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes	fungal-type cell wall organization|5-phosphoribose 1-diphosphate biosynthetic process|regulation of cell size	ribose phosphate diphosphokinase activity	cytoplasm
YLR069C	YLR069C	MEF1	hom	Verified	2.11153868813839	0.0173630180951709	no	155	0.0235009666277333	176	NA	FT	TRANSLATION|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial elongation factor involved in translational elongation	mitochondrial translational elongation|mitochondrial translation	translation elongation factor activity	mitochondrion
YOR021C	YOR021C	SFM1	hom	Verified	2.10783390769918	0.0175226793762138	no	156	0.0137648665110384	104	NA					SPOUT methyltransferase; catalyzes omega-monomethylation of Rps3p on Arg-146; not an essential gene; predicted to be involved in rRNA processing and ribosome biogenesis and in biopolymer catabolism	peptidyl-arginine methylation	protein-arginine omega-N monomethyltransferase activity	cellular_component
YBR007C	YBR007C	DSF2	hom	Verified	2.09292577851506	0.0181778903247612	no	157	0.0229718989281483	264	NA	FF				Deletion suppressor of mpt5 mutation; relocalizes from bud neck to cytoplasm upon DNA replication stress	biological_process	molecular_function	cellular_component
YMR194C-A_d	YMR194C-A	YMR194C-A	hom	Dubious	2.09004304306049	0.0183069666693531	no	158	0.0139665827808006	128	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YJL030W	YJL030W	MAD2	hom	Verified	2.08809513227404	0.0183946270342647	no	159	0.0163730520285481	125	NA	FT	CELL CYCLE|CELL DIVISION	ENDOMEMBRANE SYSTEM|NUCLEUS|CHROMOSOME	NUCLEAR PORE|KINETOCHORE	Component of the spindle-assembly checkpoint complex; delays the onset of anaphase in cells with defects in mitotic spindle assembly; forms a complex with Mad1p; regulates APC/C activity during prometaphase and metaphase of meiosis I	chromosome decondensation|mitotic cell cycle spindle assembly checkpoint|mitotic cell cycle G2/M transition decatenation checkpoint	molecular_function	mitotic checkpoint complex|condensed nuclear chromosome kinetochore|nuclear pore
YDL035C	YDL035C	GPR1	hom	Verified	2.08255414009906	0.0186459415456268	no	160	0.0301740481751256	177	NA	FT	SIGNALING	PLASMA MEMBRANE		Plasma membrane G protein coupled receptor (GPCR) that interacts with the heterotrimeric G protein alpha subunit, Gpa2p, and with Plc1p; sensor that integrates nutritional signals with the modulation of cell fate via PKA and cAMP synthesis	replicative cell aging|G-protein coupled receptor signaling pathway|sucrose mediated signaling|glucose mediated signaling pathway|pseudohyphal growth|hexose mediated signaling|invasive growth in response to glucose limitation|detection of glucose|detection of sucrose stimulus	G-protein coupled receptor activity|glucose binding	integral to membrane|plasma membrane
YDR471W	YDR471W	RPL27B	hom	Verified	2.07311567218516	0.0190807579054138	no	161	0.0177059899474254	120	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L27B; homologous to mammalian ribosomal protein L27, no bacterial homolog; RPL27B has a paralog, RPL27A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YBL091C-A	YBL091C-A	SCS22	hom	Verified	2.0667638027401	0.0193782079161044	no	162	0.018501315954043	142	NA	FT	LIPID METABOLISM			Protein involved in regulation of phospholipid metabolism; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; similar to D. melanogaster inturned protein; SCS22 has a paralog, SCS2, that arose from the whole genome duplication	phospholipid biosynthetic process|chromatin silencing at telomere	molecular_function	cellular_component
YPL195W	YPL195W	APL5	hom	Verified	2.06657799350988	0.019386968106806	no	163	0.0334796292042921	204	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Delta adaptin-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway, suppressor of loss of casein kinase 1 function	vesicle-mediated transport|Golgi to vacuole transport	protein binding	AP-3 adaptor complex
YNL298W	YNL298W	CLA4	hom	Verified	2.0597933843466	0.0197091486517835	no	164	0.050448881208987	311	NA	FF|FT	CELL CYCLE|SIGNALING|CELL DIVISION|PROTEIN PHOSPHORYLATION	NUCLEUS		Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family, along with Ste20p and Skm1p; involved in septin ring assembly, vacuole inheritance, cytokinesis, sterol uptake regulation; phosphorylates Cdc3p and Cdc10p	negative regulation of gene expression|vacuole inheritance|protein phosphorylation|budding cell apical bud growth|Rho protein signal transduction|regulation of exit from mitosis|establishment of cell polarity|sterol import|response to pheromone|cytokinesis	protein serine/threonine kinase activity|protein kinase activity	nucleus|cellular bud|fungal-type vacuole
YML071C	YML071C	COG8	hom	Verified	2.05495308134938	0.0199417683476446	no	165	0.142311630420453	603	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments	intra-Golgi vesicle-mediated transport|CVT pathway	molecular_function	Golgi transport complex
YDR268W	YDR268W	MSW1	hom	Verified	2.05392228949625	0.0199916068130231	no	166	0.029600655603811	204	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial tryptophanyl-tRNA synthetase	mitochondrial tryptophanyl-tRNA aminoacylation	tryptophan-tRNA ligase activity	mitochondrion
YMR313C	YMR313C	TGL3	hom	Verified	2.0511653406433	0.0201254239591716	no	167	0.0173249087574701	130	NA	FT	LIPID METABOLISM|CELL DIVISION			Bifunctional enzyme with triacylglycerol lipase and lysophosphatidylethanolamine acyltransferase activity; responsible for all the triacylglycerol lipase activity of the lipid particle; required with Tgl4p for timely bud formation	triglyceride catabolic process|cell budding|cellular lipid metabolic process	triglyceride lipase activity|lysophosphatidylethanolamine acyltransferase activity	lipid particle
YCR024C-A	YCR024C-A	PMP1	hom	Verified	2.04822506208972	0.0202689759123383	no	168	0.0332171054834275	218	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Regulatory subunit for the plasma membrane H(+)-ATPase Pma1p; small single-membrane span proteolipid; forms unique helix and positively charged cytoplasmic domain that is able to specifically segregate phosphatidylserines; PMP1 has a paralog, PMP2, that arose from the whole genome duplication	cation transport	enzyme regulator activity	plasma membrane|membrane
YGR220C	YGR220C	MRPL9	hom	Verified	2.04724627545921	0.020316954968326	no	169	0.0169135272009877	86	NA	FT	TRANSLATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit	cytoplasmic translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YBR149W	YBR149W	ARA1	hom	Verified	2.04060738396051	0.0206449338251217	no	170	0.0165076741674266	105	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM			NADP+ dependent arabinose dehydrogenase, involved in carbohydrate metabolism; purified as homodimer; naturally occurs with a N-terminus degradation product	cellular carbohydrate metabolic process	alditol:NADP+ 1-oxidoreductase activity|D-arabinose 1-dehydrogenase [NAD(P)+] activity	cytosol
YMR188C	YMR188C	MRPS17	hom	Verified	2.03867322599213	0.0207413258072129	no	171	0.0217315850583224	168	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the small subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YKR036C	YKR036C	CAF4	hom	Verified	2.03146732926266	0.0211038052293362	no	172	0.0184565495338121	135	NA	FT	TRANSCRIPTION FROM RNA POL II|MITOCHONDRION ORGANIZATION|PEROXISOME ORGANIZATION	NUCLEUS|MITOCHONDRION		WD40 repeat-containing protein associated with the CCR4-NOT complex; interacts in a Ccr4p-dependent manner with Ssn2p; also interacts with Fis1p, Mdv1p and Dnm1p and plays a role in mitochondrial fission; CAF4 has a paralog, MDV1, that arose from the whole genome duplication	peroxisome fission|mitochondrial fission|regulation of transcription from RNA polymerase II promoter	molecular_function	mitochondrion|CCR4-NOT complex
YER066W_p	YER066W	RRT13	hom	Uncharacterized	2.03145553660484	0.0211044028021185	no	173	0.0090845141288987	96	NA					Putative protein of unknown function; non-essential gene identified in a screen for mutants with decreased levels of rDNA transcription	biological_process	molecular_function	cellular_component
YNL311C	YNL311C	SKP2	hom	Verified	2.02237897456367	0.0215686077377673	no	174	0.0145137973219706	80	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|PROTEOLYSIS		UBIQUITIN LIGASE COMPLEX	F-box protein of unknown function predicted to be part of an SCF ubiquitin protease complex; involved in regulating protein levels of sulfur metabolism enzymes; may interact with ribosomes, based on co-purification experiments	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|cellular protein catabolic process|regulation of sulfur amino acid metabolic process	ubiquitin-protein ligase activity|protein binding, bridging	ribosome|SCF ubiquitin ligase complex
YPL144W	YPL144W	POC4	hom	Verified	2.01705172244866	0.0218450579932719	no	175	0.0197023189835456	146	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS			Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions	proteasome assembly|chaperone-mediated protein complex assembly	molecular_function	intracellular|cytoplasm
YOL147C	YOL147C	PEX11	hom	Verified	2.01486854630152	0.0219592122299513	no	176	0.0145099915796614	111	NA	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|PEROXISOME ORGANIZATION	ENDOPLASMIC RETICULUM		Peroxisomal membrane protein required for medium-chain fatty acid oxidation and peroxisome proliferation, possibly by inducing membrane curvature; localization regulated by phosphorylation; transcription regulated by Adr1p and Pip2p-Oaf1p	peroxisome fission|fatty acid oxidation	molecular_function	endoplasmic reticulum|peroxisomal membrane
YLL044W_d	YLL044W	YLL044W	hom	Dubious	2.01163233253698	0.0221293542444101	no	177	0.0224411769546805	161	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcription of both YLL044W and the overlapping gene RPL8B is reduced in the gcr1 null mutant	Unknown	Unknown	Unknown
YHR046C	YHR046C	INM1	hom	Verified	2.00850699063209	0.0222947219722545	no	178	0.0285768356125299	167	NA	FT	LIPID METABOLISM|CARBOHYDRATE METABOLISM	NUCLEUS		Inositol monophosphatase, involved in biosynthesis of inositol and in phosphoinositide second messenger signaling; INM1 expression increases in the presence of inositol and decreases upon exposure to antibipolar drugs lithium and valproate	inositol phosphate dephosphorylation	inositol monophosphate 1-phosphatase activity	nucleus|cytoplasm
YIL014C-A_p	YIL014C-A	YIL014C-A	hom	Uncharacterized	2.00664559185496	0.0223937065578032	no	179	0.0308122087417319	191	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YHR097C_p	YHR097C	YHR097C	hom	Uncharacterized	2.0035041810025	0.0225615996385504	no	180	0.0214137777275032	154	NA	FT		NUCLEUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus	biological_process	molecular_function	nucleus|cytoplasm
YPL177C	YPL177C	CUP9	hom	Verified	1.99921045278254	0.0227927940359946	no	181	0.0250731398953149	174	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Homeodomain-containing transcriptional repressor; regulates expression of PTR2, which encodes a major peptide transporter; imported peptides activate ubiquitin-dependent proteolysis, resulting in degradation of Cup9p and de-repression of PTR2 transcription; CUP9 has a paralog, TOS8, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress	negative regulation of dipeptide transport by negative regulation of transcription from RNA polymerase II promoter|negative regulation of oligopeptide transport by negative regulation of transcription from RNA polymerase II promoter	RNA polymerase II repressing transcription factor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity	nucleus
YHR179W	YHR179W	OYE2	hom	Verified	1.99897244394813	0.0228056677293801	no	182	0.0221779921256909	210	NA	FT	OXIDATION-REDUCTION PROCESS	NUCLEUS|MITOCHONDRION		Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN); responsible for geraniol reduction into citronellol during fermentation; homologous to Oye3p with different ligand binding and catalytic properties; may be involved in sterol metabolism, oxidative stress response, and programmed cell death; protein abundance increases in response to DNA replication stress	apoptotic process	NADPH dehydrogenase activity	mitochondrion|nucleus|cytoplasm
YJL168C	YJL168C	SET2	hom	Verified	1.99757973703652	0.0228811209290825	no	183	0.0190081894113238	156	NA	FT	CELL CYCLE|CHROMATIN ORGANIZATION	NUCLEUS|CHROMOSOME		Histone methyltransferase with a role in transcriptional elongation; methylates H3 lysine 36, which suppresses incorporation of acetylated histones and signals for the deacetylation of these histones within transcribed genes; associates with the C-terminal domain of Rpo21p; histone methylation activity is regulated by phosphorylation status of Rpo21p	negative regulation of histone H3-K14 acetylation|DNA-dependent transcription, elongation|ascospore formation|regulation of transcription, DNA-dependent|histone deacetylation|regulation of DNA-dependent DNA replication initiation|histone methylation|negative regulation of antisense RNA transcription|Unknown|negative regulation of reciprocal meiotic recombination|positive regulation of histone acetylation	histone methyltransferase activity|histone methyltransferase activity (H3-K36 specific)	nucleus
YDR286C_p	YDR286C	YDR286C	hom	Uncharacterized	1.99178523049753	0.0231973137207724	no	184	0.0129997000945008	59	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY			Putative protein of unknown function; predicted to have thiol-disulfide oxidoreductase active site	biological_process	molecular_function	cellular_component
YML009C	YML009C	MRPL39	hom	Verified	1.98603071074195	0.0235149569895252	no	185	0.0167990275892752	96	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YIL161W_p	YIL161W	YIL161W	hom	Uncharacterized	1.98471062639772	0.0235883379307274	no	186	0.0145541154254168	110	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; mRNA is enriched in Scp160p-associated mRNPs; YIL161W is a non-essential gene	biological_process	molecular_function	cytoplasm
YLR135W	YLR135W	SLX4	hom	Verified	1.98420314919965	0.0236165988161641	no	187	0.016907178989108	96	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Endonuclease involved in processing DNA; acts during recombination and repair; cleaves branched structures in a complex with Slx1p; involved interstrand cross-link repair and in Rad1p/Rad10p-dependent removal of 3'-nonhomologous tails during DSBR via single-strand annealing; relative distribution to nuclear foci increases upon DNA replication stress	double-strand break repair via single-strand annealing, removal of nonhomologous ends|DNA replication|response to DNA damage stimulus|DNA-dependent DNA replication	5'-flap endonuclease activity	Slx1-Slx4 complex|nucleus
YLR080W	YLR080W	EMP46	hom	Verified	1.97893888397478	0.0239114438341805	no	188	0.0158657402943127	79	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport	ER to Golgi vesicle-mediated transport	glycoprotein binding	ER to Golgi transport vesicle|Golgi membrane
YPR201W	YPR201W	ARR3	hom	Verified	1.97454576945257	0.0241598592490121	no	189	0.0185042819791412	156	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Plasma membrane metalloid/H+ antiporter; transports arsenite and antimonite; required for resistance to arsenic compounds; transcription is activated by Arr1p in the presence of arsenite	arsenite transport|antimonite transport	antiporter activity|arsenite transmembrane transporter activity|antimonite transmembrane transporter activity	integral to membrane|plasma membrane
YER065C	YER065C	ICL1	hom	Verified	1.97220785403671	0.0242929417266662	no	190	0.015805537397172	92	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM			Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose	glyoxylate cycle	isocitrate lyase activity	cellular_component
YCR075C	YCR075C	ERS1	hom	Verified	1.97210042453545	0.0242990717608341	no	191	0.0186165437527461	163	NA					Protein with similarity to human cystinosin, which is a H(+)-driven transporter involved in L-cystine export from lysosomes and implicated in the disease cystinosis; contains seven transmembrane domains	L-cystine transport|transmembrane transport	L-cystine transmembrane transporter activity	endosome|integral to membrane|fungal-type vacuole
YOR140W	YOR140W	SFL1	hom	Verified	1.96836213376856	0.024513192759572	no	192	0.023088818937748	143	NA	FT	TRANSCRIPTION FROM RNA POL II|GENE SILENCING	NUCLEUS		Transcriptional repressor and activator; involved in repression of flocculation-related genes, and activation of stress responsive genes; negatively regulated by cAMP-dependent protein kinase A subunit Tpk2p	gene silencing|Unknown|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II repressing transcription factor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity	nucleus
YKR075C_p	YKR075C	YKR075C	hom	Uncharacterized	1.96701112966431	0.0245909638458758	no	193	0.0288645554701128	191	NA	FT		NUCLEUS		Protein of unknown function; similar to YOR062Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS	biological_process	molecular_function	nucleus|cytoplasm
YMR267W	YMR267W	PPA2	hom	Verified	1.95696518657181	0.0251757807663701	no	194	0.0430564820359293	270	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Mitochondrial inorganic pyrophosphatase, required for mitochondrial function and possibly involved in energy generation from inorganic pyrophosphate	aerobic respiration	inorganic diphosphatase activity	mitochondrion
YER175C	YER175C	TMT1	hom	Verified	1.95199506569188	0.025469395221103	no	195	0.0103197637709214	104	NA					Trans-aconitate methyltransferase, cytosolic enzyme that catalyzes the methyl esterification of 3-isopropylmalate, an intermediate of the leucine biosynthetic pathway, and trans-aconitate, which inhibits the citric acid cycle	biological_process	trans-aconitate 3-methyltransferase activity	cytosol
YOR138C	YOR138C	RUP1	hom	Verified	1.95080300254426	0.0255402422733898	no	196	0.0309455647066877	180	NA	FT		NUCLEUS		Protein that regulates Rsp5p, which is a HECT ubiquitin ligase; has a WW domain consensus motif of PPPSY (residues 131-135) that mediates binding of Rsp5p to Ubp2p; contains an UBA domain; relative distribution to the nucleus increases upon DNA replication stress	protein deubiquitination	protein binding	nucleus|cytoplasm
YPR062W	YPR062W	FCY1	hom	Verified	1.94898067664818	0.025648866198759	no	197	0.0354419958662843	221	NA	FT		NUCLEUS		Cytosine deaminase, zinc metalloenzyme that catalyzes the hydrolytic deamination of cytosine to uracil; of biomedical interest because it also catalyzes the deamination of 5-fluorocytosine (5FC) to form anticancer drug 5-fluorouracil (5FU)	cytosine metabolic process|pyrimidine-containing compound salvage|cytidine metabolic process	cytosine deaminase activity	nucleus|cytoplasm
YOR226C	YOR226C	ISU2	hom	Verified	1.94597091752679	0.0258291165742211	no	198	0.0220893123747675	177	NA	FT	RNA PROCESSING|ION HOMEOSTASIS|ION HOMEOSTASIS|COFACTOR METABOLISM	MITOCHONDRION		Protein required for synthesis of iron-sulfur proteins; localized to the mitochondrial matrix; performs a scaffolding function in mitochondria during Fe/S cluster assembly; involved in Fe-S cluster assembly for both mitochondrial and cytosolic proteins; isu1 isu2 double mutant is inviable; protein abundance increases in response to DNA replication stress; evolutionarily conserved	cellular iron ion homeostasis|iron-sulfur cluster assembly|tRNA wobble uridine modification	molecular_function	mitochondrial matrix
YPL038W	YPL038W	MET31	hom	Verified	1.94465107712594	0.0259084937073208	no	199	0.028820238401783	174	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Zinc-finger DNA-binding transcription factor; involved in transcriptional regulation of the methionine biosynthetic genes; MET31 has a paralog, MET32, that arose from the whole genome duplication	regulation of sulfur amino acid metabolic process|regulation of transcription from RNA polymerase II promoter	core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity	nucleus|cytoplasm
YCR036W	YCR036W	RBK1	hom	Verified	1.94419820108081	0.0259357773228691	no	200	0.05675786904242	276	NA	FT	CARBOHYDRATE METABOLISM	NUCLEUS		Putative ribokinase	D-ribose metabolic process	ribokinase activity|ATP binding	nucleus|cytoplasm
YGR018C_p	YGR018C	YGR018C	hom	Uncharacterized	1.94219654440454	0.0260566556368885	no	201	0.0127008410074575	101	NA					Protein of unknown function; mRNA identified as translated by ribosome profiling data; partially overlaps the uncharacterized ORF YGR017W	biological_process	molecular_function	cellular_component
YGR271C-A	YGR271C-A	EFG1	hom	Verified	1.94047908126821	0.0261607470115194	no	202	0.0423145349599025	232	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Essential protein required for maturation of 18S rRNA; null mutant is sensitive to hydroxyurea and is delayed in recovering from alpha-factor arrest; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus	G1 phase of mitotic cell cycle|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	molecular_function	nucleolus
YDR538W	YDR538W	PAD1	hom	Verified	1.93762382364515	0.0263345668741018	no	203	0.0230751707978093	218	NA	FT	KETONE METABOLISM	MITOCHONDRION		Phenylacrylic acid decarboxylase, confers resistance to cinnamic acid, decarboxylates aromatic carboxylic acids to the corresponding vinyl derivatives; also has mRNA binding activity; homolog of E. coli UbiX	cinnamic acid catabolic process|aromatic compound catabolic process	mRNA binding|carboxy-lyase activity	mitochondrion
YMR174C	YMR174C	PAI3	hom	Verified	1.93516549027704	0.0264849955311282	no	204	0.0214088792852183	140	NA					Cytoplasmic proteinase A (Pep4p) inhibitor, dependent on Pbs2p and Hog1p protein kinases for osmotic induction; intrinsically unstructured, N-terminal half becomes ordered in the active site of proteinase A upon contact	vacuolar protein catabolic process	endopeptidase inhibitor activity	cytoplasm
YCR046C	YCR046C	IMG1	hom	Verified	1.93313826179101	0.0266095838755161	no	205	0.033026232255493	203	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit, required for respiration and for maintenance of the mitochondrial genome	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YER164W	YER164W	CHD1	hom	Verified	1.93150549040045	0.0267102855012264	no	206	0.0389499828439488	206	NA	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|CHROMATIN ORGANIZATION	NUCLEUS|MITOCHONDRION|CHROMOSOME	HISTONE ACETYLTRANSFERASE	Chromatin remodeler that regulates various aspects of transcription; acts in in conjunction with Isw1b to regulate chromatin structure and maintain chromatin integrity during transcription elongation by RNAP II by preventing trans-histone exchange over coding regions; contains a chromo domain, a helicase domain and a DNA-binding domain; component of both the SAGA and SLIK complexes	termination of RNA polymerase I transcription|ATP-dependent chromatin remodeling|nucleosome positioning|negative regulation of histone H3-K14 acetylation|termination of RNA polymerase II transcription|regulation of transcription by chromatin organization|regulation of transcriptional start site selection at RNA polymerase II promoter|nucleosome mobilization|Unknown|transcription elongation from RNA polymerase II promoter	chromatin DNA binding|DNA-dependent ATPase activity|methylated histone residue binding|DNA binding|rDNA binding	nuclear chromatin|SLIK (SAGA-like) complex|mitochondrion|SAGA complex|nucleolar chromatin
YOR382W	YOR382W	FIT2	hom	Verified	1.93134537365411	0.0267201778596611	no	207	0.0128834542224014	89	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall	siderophore transport	molecular_function	fungal-type cell wall
YOR099W	YOR099W	KTR1	hom	Verified	1.92415288649532	0.0271677113069073	no	208	0.0190177526300181	136	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Alpha-1,2-mannosyltransferase; involved in O- and N-linked protein glycosylation; type II membrane protein; member of the KRE2/MNT1 mannosyltransferase family; relocalizes from vacuole to cytoplasm upon DNA replication stress	N-glycan processing|cell wall mannoprotein biosynthetic process|protein O-linked glycosylation	alpha-1,2-mannosyltransferase activity	Golgi apparatus
YPR185W	YPR185W	ATG13	hom	Verified	1.9200807532124	0.0274238500039772	no	209	0.0204836108909003	131	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|PROTEIN PHOSPHORYLATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS			Regulatory subunit of the Atg1p signaling complex; stimulates Atg1p kinase activity; required for vesicle formation during autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; involved in Atg9p, Atg23p, and Atg27p cycling	piecemeal microautophagy of nucleus|mitochondrion degradation|macroautophagy|activation of protein kinase activity|CVT pathway	protein kinase regulator activity	Atg1p signaling complex|extrinsic to membrane
YGL212W	YGL212W	VAM7	hom	Verified	1.91766680541008	0.0275766366695995	no	210	0.0342136451187206	225	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION			Vacuolar SNARE protein; functions with Vam3p in vacuolar protein trafficking; has an N-terminal PX domain (phosphoinositide-binding module) that binds PtdIns-3-P and mediates membrane binding; SNAP-25 homolog; protein abundance increases in response to DNA replication stress	piecemeal microautophagy of nucleus|vacuole fusion, non-autophagic|vesicle fusion	SNAP receptor activity|phosphatidylinositol-3-phosphate binding	SNARE complex|fungal-type vacuole membrane
YOR139C_d	YOR139C	YOR139C	hom	Dubious	1.91150047850125	0.0279701476822915	no	211	0.0402481149258937	197	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SFL1/YOR140W	Unknown	Unknown	Unknown
YPR003C_p	YPR003C	YPR003C	hom	Uncharacterized	1.91079096768535	0.028015724457714	no	212	0.0366940445996301	169	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Putative sulfate permease; physically interacts with Hsp82p; green fluorescent protein (GFP)-fusion protein localizes to the ER; YPR003C is not an essential gene	biological_process	molecular_function	integral to membrane|endoplasmic reticulum
YGL234W	YGL234W	ADE5,7	hom	Verified	1.90690738773217	0.0282662906715052	no	213	0.0250801170349073	182	NA	FT	NUCLEOTIDE METABOLISM			Bifunctional enzyme of the 'de novo' purine nucleotide biosynthetic pathway, contains aminoimidazole ribotide synthetase and glycinamide ribotide synthetase activities	purine nucleobase metabolic process|purine nucleotide biosynthetic process|'de novo' IMP biosynthetic process	phosphoribosylamine-glycine ligase activity|phosphoribosylformylglycinamidine cyclo-ligase activity	cytoplasm
YJL169W_d	YJL169W	YJL169W	hom	Dubious	1.89997902657715	0.028717936031651	no	214	0.025885319266833	174	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL168C/SET2	Unknown	Unknown	Unknown
YDR400W	YDR400W	URH1	hom	Verified	1.89812857736368	0.0288395732353194	no	215	0.0218458013163918	110	NA	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM	NUCLEUS		Uridine nucleosidase (uridine-cytidine N-ribohydrolase), cleaves N-glycosidic bonds in nucleosides; involved in the pyrimidine salvage and nicotinamide riboside salvage pathways	pyrimidine-containing compound salvage|NAD biosynthesis via nicotinamide riboside salvage pathway|pyrimidine nucleoside catabolic process|nicotinate nucleotide salvage	ribosylpyrimidine nucleosidase activity|nicotinic acid riboside hydrolase activity|nicotinamide riboside hydrolase activity|uridine nucleosidase activity	nucleus|cytoplasm
YJL212C	YJL212C	OPT1	hom	Verified	1.89636181395497	0.0289561088238949	no	216	0.0268390927989599	162	NA	FT	PROTEIN LOCALIZATION	PLASMA MEMBRANE		Proton-coupled oligopeptide transporter of the plasma membrane; also transports glutathione and phytochelatin; member of the OPT family	oligopeptide transport|sulfur compound metabolic process	oligopeptide transporter activity|proton-dependent oligopeptide secondary active transmembrane transporter activity	integral to membrane|integral to plasma membrane
YGR133W	YGR133W	PEX4	hom	Verified	1.89192102001643	0.0292507523365159	no	217	0.0190787741472276	121	NA	FT	PROTEIN LOCALIZATION|SIGNALING|PEROXISOME ORGANIZATION			Peroxisomal ubiquitin conjugating enzyme required for peroxisomal matrix protein import and peroxisome biogenesis	peroxisome organization|protein import into peroxisome matrix, receptor recycling|protein autoubiquitination|protein monoubiquitination|protein polyubiquitination	ubiquitin-protein ligase activity	peroxisome
YJL149W	YJL149W	DAS1	hom	Verified	1.89163064389797	0.0292701050108714	no	218	0.0370878859955457	228	NA	FT	PROTEOLYSIS		UBIQUITIN LIGASE COMPLEX	Putative SCF ubiquitin ligase F-box protein; interacts physically with both Cdc53p and Skp1 and genetically with CDC34; similar to putative F-box protein YDR131C	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	ubiquitin-protein ligase activity|protein binding, bridging	SCF ubiquitin ligase complex
YPR101W	YPR101W	SNT309	hom	Verified	1.89029357389119	0.029359353879741	no	219	0.039918319631274	249	NA	FT	RNA PROCESSING	NUCLEUS		Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; interacts physically and genetically with Prp19p	mRNA splicing, via spliceosome	first spliceosomal transesterification activity	Prp19 complex|U2-type catalytic step 1 spliceosome
YMR072W	YMR072W	ABF2	hom	Verified	1.89005676516372	0.0293751842956226	no	220	0.0307388942149139	209	NA	FT	MITOCHONDRION ORGANIZATION	NUCLEUS|MITOCHONDRION|CHROMOSOME		Mitochondrial DNA-binding protein involved in mitochondrial DNA replication and recombination, member of HMG1 DNA-binding protein family; activity may be regulated by protein kinase A phosphorylation	mitochondrion inheritance|mitochondrial DNA packaging|mitochondrial genome maintenance	DNA binding, bending|DNA binding	mitochondrial nucleoid|mitochondrial chromosome|mitochondrion
YBR240C	YBR240C	THI2	hom	Verified	1.88588862447671	0.0296549823789119	no	221	0.0411797177286468	206	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Transcriptional activator of thiamine biosynthetic genes; interacts with regulatory factor Thi3p to control expression of thiamine biosynthetic genes with respect to thiamine availability; acts together with Pdc2p to respond to thiaminediphosphate demand, possibly as related to carbon source availability; zinc finger protein of the Zn(II)2Cys6 type	thiamine biosynthetic process|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II activating transcription factor binding|RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription	nucleus
YLR308W	YLR308W	CDA2	hom	Verified	1.87693257215295	0.030263667964781	no	222	0.028137983762308	163	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM			Chitin deacetylase, together with Cda1p involved in the biosynthesis ascospore wall component, chitosan; required for proper rigidity of the ascospore wall	ascospore wall assembly	chitin deacetylase activity	chitosan layer of spore wall
YLR361C-A_p	YLR361C-A	YLR361C-A	hom	Uncharacterized	1.87455674504059	0.0304268642957799	no	223	0.0189776979719287	147	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YDR231C	YDR231C	COX20	hom	Verified	1.87250404650706	0.0305684513001287	no	224	0.031168439458125	168	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase	mitochondrial respiratory chain complex IV assembly|protein processing|aerobic respiration	unfolded protein binding	mitochondrion|mitochondrial inner membrane
YHR014W	YHR014W	SPO13	hom	Verified	1.86741448755676	0.0309218641030047	no	225	0.0160790690081785	116	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME		Meiosis-specific protein, involved in maintaining sister chromatid cohesion during meiosis I as well as promoting proper attachment of kinetochores to the spindle during meiosis I and meiosis II	protein localization to chromosome, centromeric region|meiotic sister chromatid cohesion|positive regulation of sister chromatid cohesion	molecular_function	nucleus|condensed nuclear chromosome, centromeric region
YBR188C	YBR188C	NTC20	hom	Verified	1.86566393675927	0.0310441991084174	no	226	0.0248723397763752	153	NA	FT	RNA PROCESSING	NUCLEUS		Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs	mRNA splicing, via spliceosome	first spliceosomal transesterification activity	Prp19 complex|U2-type catalytic step 1 spliceosome
YLR446W_p	YLR446W	YLR446W	hom	Uncharacterized	1.86432381020772	0.0311381225414474	no	227	0.026958283351107	212	NA	FT	CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY			Putative hexokinase; transcript is upregulated during sporulation and the unfolded protein response; YLR446W is not an essential gene	biological_process	molecular_function	cellular_component
YPL055C	YPL055C	LGE1	hom	Verified	1.86282528023065	0.0312434260298327	no	228	0.0445754740626805	265	NA	FT	CHROMATIN ORGANIZATION	NUCLEUS		Protein of unknown function; null mutant forms abnormally large cells, and homozygous diploid null mutant displays delayed premeiotic DNA synthesis and reduced efficiency of meiotic nuclear division	histone methylation|protein monoubiquitination|regulation of cell size|histone ubiquitination|premeiotic DNA replication	molecular_function	nucleus
YMR215W	YMR215W	GAS3	hom	Verified	1.85839637949983	0.0315563730272857	no	229	0.027200374759769	149	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM			Low abundance, possibly inactive member of the GAS family of GPI-containing proteins; putative 1,3-beta-glucanosyltransferase with similarity to other GAS family members; localizes to the cell wall; mRNA induced during sporulation	biological_process	1,3-beta-glucanosyltransferase activity	fungal-type cell wall|integral to membrane|plasma membrane
YBR116C_d	YBR116C	YBR116C	hom	Dubious	1.85641034028229	0.0316975459922095	no	230	0.0209343803012112	127	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene TKL2	Unknown	Unknown	Unknown
YCR087W_d	YCR087W	YCR087W	hom	Dubious	1.85465133765087	0.0318230159908426	no	231	0.0391483341953264	203	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized gene YCR087C-A; YCR087W is not an essential gene	Unknown	Unknown	Unknown
YBR214W	YBR214W	SDS24	hom	Verified	1.85277067263131	0.0319576177259027	no	232	0.0316612961998233	139	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CELL DIVISION			Protein involved in cell separation during budding; one of two S. cerevisiae homologs (Sds23p and Sds24p) of the S. pombe Sds23 protein, which is implicated in APC/cyclosome regulation; may play an indirect role in fluid-phase endocytosis; protein abundance increases in response to DNA replication stress; SDS24 has a paralog, SDS23, that arose from the whole genome duplication	endocytosis|cytokinetic cell separation	molecular_function	cytoplasm
YJR010W	YJR010W	MET3	hom	Verified	1.84877051461285	0.0322454783251754	no	233	0.0291738916900252	164	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		ATP sulfurylase, catalyzes the primary step of intracellular sulfate activation, essential for assimilatory reduction of sulfate to sulfide, involved in methionine metabolism	sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)|sulfur amino acid metabolic process	sulfate adenylyltransferase (ATP) activity	mitochondrion|cytoplasm
YBR183W	YBR183W	YPC1	hom	Verified	1.84466972315974	0.0325427988688289	no	234	0.0375838084275116	182	NA	FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Alkaline ceramidase; also has reverse (CoA-independent) ceramide synthase activity; catalyzes both breakdown and synthesis of phytoceramide; overexpression confers fumonisin B1 resistance; YPC1 has a paralog, YDC1, that arose from the whole genome duplication	ceramide catabolic process|ceramide biosynthetic process	phytoceramidase activity|sphingosine N-acyltransferase activity	integral to membrane|endoplasmic reticulum
YNL254C	YNL254C	RTC4	hom	Verified	1.84462162592507	0.0325462994441027	no	235	0.0201786051374761	138	NA	FT		NUCLEUS		Protein of unknown function; null mutation suppresses cdc13-1 temperature sensitivity; (GFP)-fusion protein localizes to both the cytoplasm and the nucleus	biological_process	molecular_function	nucleus|cytoplasm
YOL051W	YOL051W	GAL11	hom	Verified	1.83968708401907	0.0329070954375369	no	236	0.0799934197535352	403	NA	FF|FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS	RNA POL II, HOLOENZYME	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; affects transcription by acting as target of activators and repressors; forms part of the tail domain of mediator	negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II transcriptional preinitiation complex assembly|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly|TFIIE-class binding transcription factor activity|RNA polymerase II activating transcription factor binding|TFIIE-class transcription factor binding|TFIIH-class transcription factor binding|RNA polymerase II transcription factor recruiting transcription factor activity	core mediator complex
YMR316W	YMR316W	DIA1	hom	Verified	1.83859793895164	0.0329871723294063	no	237	0.0416105247485622	253	NA					Protein of unknown function, involved in invasive and pseudohyphal growth; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern	pseudohyphal growth|invasive growth in response to glucose limitation	molecular_function	cytoplasm
YOR035C	YOR035C	SHE4	hom	Verified	1.83816396760786	0.0330191237845613	no	238	0.105694615859967	470	NA	FF|FT	CYTOSKELETON ORGANIZATION|RNA LOCALIZATION			Protein containing a UCS (UNC-45/CRO1/SHE4) domain, binds to myosin motor domains to regulate myosin function; involved in endocytosis, polarization of the actin cytoskeleton, and asymmetric mRNA localization	mating type switching|intracellular mRNA localization|actin cytoskeleton organization	myosin binding	cytoplasm
YER107C	YER107C	GLE2	hom	Verified	1.83634087377026	0.0331536291129773	no	239	0.0700715894158445	347	NA	FF|FT	PROTEIN LOCALIZATION|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	RNA export factor associated with the nuclear pore complex (NPC); associates with NUP116p; required for polyadenylated RNA export but not for protein import; homologous to S. pombe Rae1p and human RAE1	poly(A)+ mRNA export from nucleus|Unknown|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|nuclear pore distribution|transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery	molecular_function	integral to membrane|nuclear pore|cytoplasm
YOR274W	YOR274W	MOD5	hom	Verified	1.83325857710298	0.0333820631879708	no	240	0.0382993873157785	198	NA	FT	RNA PROCESSING	NUCLEUS|MITOCHONDRION		Delta 2-isopentenyl pyrophosphate:tRNA isopentenyl transferase; required for biosynthesis of the modified base isopentenyladenosine in mitochondrial and cytoplasmic tRNAs; gene is nuclear and encodes two isozymic forms; converts to a prion form, and prion conversion contributes to azole antifungal resistance by upregulating ergosterol biosynthesis	tRNA modification	tRNA dimethylallyltransferase activity	cytosol|mitochondrion|nucleolus|nucleus
YHR151C	YHR151C	MTC6	hom	Verified	1.83081586591737	0.0335640156954661	no	241	0.0317088166698617	220	NA					Protein of unknown function; mtc6 is synthetically sick with cdc13-1	biological_process	molecular_function	cellular_component
YOL122C	YOL122C	SMF1	hom	Verified	1.8276067247188	0.0338042979115761	no	242	0.0275727887334923	179	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Divalent metal ion transporter with a broad specificity for di-valent and tri-valent metals; post-translationally regulated by levels of metal ions; member of the Nramp family of metal transport proteins	copper ion transport|cellular copper ion homeostasis|manganese ion transport|cadmium ion transport|cellular manganese ion homeostasis|cellular cadmium ion homeostasis|iron ion transport	solute:hydrogen symporter activity|inorganic cation transmembrane transporter activity	integral to membrane|plasma membrane
YGR230W	YGR230W	BNS1	hom	Verified	1.82724631190862	0.0338313717451044	no	243	0.0296206179502903	185	NA	FT	CELL CYCLE			Protein with some similarity to Spo12p; overexpression bypasses need for Spo12p, but not required for meiosis	meiosis	molecular_function	cellular_component
YCL010C	YCL010C	SGF29	hom	Verified	1.81893965211392	0.0344603187459618	no	244	0.0272773445137388	193	NA	FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION	NUCLEUS	HISTONE ACETYLTRANSFERASE	Component of the HAT/Core module of the SAGA, SLIK, and ADA complexes; HAT/Core module also contains Gcn5p, Ngg1p, and Ada2p; binds methylated histone H3K4; involved in transcriptional regulation through SAGA and TBP recruitment to target promoters and H3 acetylation	histone H3-K14 acetylation|cellular protein complex localization|histone H3-K18 acetylation|cellular protein localization|histone H3-K9 acetylation|positive regulation of transcription from RNA polymerase II promoter	methylated histone residue binding|RNA polymerase II transcription factor recruiting transcription factor activity	Ada2/Gcn5/Ada3 transcription activator complex|SAGA complex
YLR125W_p	YLR125W	YLR125W	hom	Uncharacterized	1.81733333996673	0.0345830439563574	no	245	0.034199045760318	198	NA					Putative protein of unknown function; mutant has decreased Ty3 transposition; YLR125W is not an essential gene	biological_process	molecular_function	cellular_component
YGL108C	YGL108C	YGL108C	hom	Verified	1.81435907806899	0.0348112307974314	no	246	0.030628018687357	179	NA					Protein of unknown function, predicted to be palmitoylated; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	cellular_component
YOR083W	YOR083W	WHI5	hom	Verified	1.81345667599452	0.0348807074547963	no	247	0.0219016218027972	114	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE	NUCLEUS		Repressor of G1 transcription that binds to SCB binding factor (SBF) at SCB target promoters in early G1; phosphorylation of Whi5p by the CDK, Cln3p/Cdc28p relieves repression and promoter binding by Whi5; periodically expressed in G1	negative regulation of transcription involved in G1/S phase of mitotic cell cycle|regulation of cell size	RNA polymerase II transcription factor recruiting transcription factor activity|RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription	SBF transcription complex|nucleus|cytoplasm
YBR072C-A_p	YBR072C-A	YBR072C-A	hom	Uncharacterized	1.80787300425804	0.0353131340981888	no	248	0.0316629405729437	189	NA					Putative protein of unknown function; identified by fungal homology and RT-PCR	biological_process	molecular_function	cellular_component
YGL196W	YGL196W	DSD1	hom	Verified	1.80493128198001	0.0355427179727274	no	249	0.0368308177305511	205	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			D-serine dehydratase (aka D-serine ammonia-lyase); converts D-serine to pyruvate and ammonia by a reaction dependent on pyridoxal 5'-phosphate and zinc; may play a role in D-serine detoxification; L-serine is not a substrate	D-serine metabolic process	D-serine ammonia-lyase activity	cellular_component
YLR400W_d	YLR400W	YLR400W	hom	Dubious	1.80371261019997	0.0356381858286454	no	250	0.0328823402047741	157	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YMR307W	YMR307W	GAS1	hom	Verified	1.80138824694917	0.0358208536572475	no	251	0.0403960471938781	279	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|GENE SILENCING	NUCLEUS|MITOCHONDRION|PLASMA MEMBRANE		Beta-1,3-glucanosyltransferase, required for cell wall assembly and also has a role in transcriptional silencing; localizes to the cell surface via a glycosylphosphatidylinositol (GPI) anchor; also found at the nuclear periphery	fungal-type cell wall organization|chromatin silencing|filamentous growth	1,3-beta-glucanosyltransferase activity	mitochondrion|membrane raft|primary cell septum|nuclear periphery|integral to membrane|fungal-type cell wall|plasma membrane|cellular bud scar|ER to Golgi transport vesicle
YHR158C	YHR158C	KEL1	hom	Verified	1.80043592306235	0.0358959164182361	no	252	0.0369172576953272	205	NA	FT	CELL CYCLE|MEMBRANE ORGANIZATION	SITE OF POLARIZED GROWTH		Protein required for proper cell fusion and cell morphology; functions in a complex with Kel2p to negatively regulate mitotic exit, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential Cdc28p substrate	negative regulation of exit from mitosis|regulation of cell shape|cell morphogenesis|cytogamy|plasma membrane fusion	molecular_function	mating projection tip|cellular bud neck|cytoplasm|cellular bud tip
YAR030C_d	YAR030C	YAR030C	hom	Dubious	1.79922516300717	0.0359915352894231	no	253	0.0314096120040084	187	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YAR029W and the verified gene PRM9	Unknown	Unknown	Unknown
YLR312C_p	YLR312C	YLR312C	hom	Uncharacterized	1.79896248310566	0.0360123077555838	no	254	0.037549014594248	186	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YHR156C	YHR156C	LIN1	hom	Verified	1.7959401830929	0.0362520154119884	no	255	0.0369415430893548	213	NA	FT		NUCLEUS|CHROMOSOME		Non-essential component of U5 snRNP; nuclear protein; physically interacts with Irr1p of cohesin complex; may link together proteins involved in chromosome segregation, mRNA splicing and DNA replication	biological_process	protein binding	chromatin|nucleus|U4/U6 x U5 tri-snRNP complex|U5 snRNP
YBR226C_d	YBR226C	YBR226C	hom	Dubious	1.78385173264832	0.0372238803884267	no	256	0.0676024355069955	262	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YBR225W	Unknown	Unknown	Unknown
YCR106W	YCR106W	RDS1	hom	Verified	1.78364212870453	0.0372409176820267	no	257	0.0291120128311022	252	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Putative zinc cluster transcription factor; involved in conferring resistance to cycloheximide	response to xenobiotic stimulus	sequence-specific DNA binding|DNA binding	nucleus
YDR322C-A	YDR322C-A	TIM11	hom	Verified	1.78011170803218	0.0375288404374239	no	258	0.0374522908681846	176	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS	MITOCHONDRION		Subunit e of mitochondrial F1F0-ATPase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; essential for the dimeric and oligomeric state of ATP synthase	protein oligomerization|cristae formation|ATP synthesis coupled proton transport	structural molecule activity|proton-transporting ATPase activity, rotational mechanism	mitochondrion|integral to membrane|mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
YIL120W	YIL120W	QDR1	hom	Verified	1.7779434566686	0.0377065709839757	no	259	0.0322486357392264	139	NA	FT		PLASMA MEMBRANE		Multidrug transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; required for resistance to quinidine, ketoconazole, fluconazole, and barban; QDR1 has a paralog, AQR1, that arose from the whole genome duplication	drug transmembrane transport	drug transmembrane transporter activity	integral to membrane|plasma membrane
YDR348C	YDR348C	PAL1	hom	Verified	1.7764816278627	0.0378267837215608	no	260	0.0363416942748475	207	NA	FT		SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Protein of unknown function thought to be involved in endocytosis; Pal1p physically interacts with Ede1p and is found at endocytic sites at the cell periphery during the early stages of endocytosis; green fluorescent protein (GFP)-fusion protein also localizes to the bud neck; potential Cdc28p substrate; similar to the S. pombe Pal1 protein; relocalizes from bud neck to cytoplasm upon DNA replication stress	biological_process	molecular_function	cell cortex|cellular bud neck|mating projection tip
YLR082C	YLR082C	SRL2	hom	Verified	1.77496159006205	0.037952114759495	no	261	0.0380480817473525	148	NA	FT		NUCLEUS		Protein of unknown function; overexpression suppresses the lethality caused by a rad53 null mutation	nucleobase-containing compound metabolic process	molecular_function	nucleus|cytoplasm
YMR158C-A_p	YMR158C-A	YMR158C-A	hom	Uncharacterized	1.77000576009175	0.0383630905889235	no	262	0.0302859679213499	186	NA					Putative protein of unknown function, may contain a lipid attachment site; YMR158C-A is not an essential gene	biological_process	molecular_function	cellular_component
YCL037C	YCL037C	SRO9	hom	Verified	1.76930983885548	0.0384210912050778	no	263	0.0641293864467209	321	NA	FT	TRANSLATION			Cytoplasmic RNA-binding protein; associates with translating ribosomes; involved in heme regulation of Hap1p as a component of the HMC complex, also involved in the organization of actin filaments; contains a La motif; SRO9 has a paralog, SLF1, that arose from the whole genome duplication	cytoplasmic translation	RNA binding	polysome
YHR075C	YHR075C	PPE1	hom	Verified	1.76035115348909	0.0391741429703624	no	264	0.0367763846146847	192	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Protein with carboxyl methyl esterase activity that may have a role in demethylation of the phosphoprotein phosphatase catalytic subunit; also identified as a small subunit mitochondrial ribosomal protein	cellular protein modification process|mitochondrial translation	structural constituent of ribosome|carboxylesterase activity	mitochondrial small ribosomal subunit
YLR164W	YLR164W	SHH4	hom	Verified	1.75889615120225	0.0392975745145211	no	265	0.0244708016669008	113	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Mitochondrial inner membrane protein of unknown function; similar to Tim18p and Sdh4p; a fraction copurifies with Sdh3p, but Shh4p is neither a stoichiometric subunit of succinate dehydrogenase nor of the TIM22 translocase; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner	biological_process	molecular_function	mitochondrion|mitochondrial inner membrane
YLR032W	YLR032W	RAD5	hom	Verified	1.75794635386267	0.0393783188273153	no	266	0.0455263838193284	272	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		DNA helicase; proposed to promote replication fork regression during postreplication repair by template switching; RING finger containing ubiquitin ligase; stimulates the synthesis of free and PCNA-bound polyubiquitin chains by Ubc13p-Mms2p; required for error-prone translesion synthesis; forms nuclear foci upon DNA replication stress	double-strand break repair|postreplication repair|protein polyubiquitination|free ubiquitin chain polymerization	four-way junction helicase activity|four-way junction DNA binding|DNA-dependent ATPase activity|Y-form DNA binding	nuclear chromatin
YLL021W	YLL021W	SPA2	hom	Verified	1.75583653876096	0.0395581617233304	no	267	0.0495474591128371	223	NA	FT	CELL CYCLE|SIGNALING|CELL DIVISION|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH		Component of the polarisome, which functions in actin cytoskeletal organization during polarized growth; acts as a scaffold for Mkk1p and Mpk1p cell wall integrity signaling components; potential Cdc28p substrate	regulation of initiation of mating projection growth|regulation of termination of mating projection growth|pseudohyphal growth|invasive filamentous growth|mating projection assembly	cytoskeletal regulatory protein binding	incipient cellular bud site|cellular bud neck|mating projection tip|cellular bud tip
YPL245W_p	YPL245W	YPL245W	hom	Uncharacterized	1.7537339913866	0.0397380491252949	no	268	0.0383263864235153	188	NA	FT		NUCLEUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm	biological_process	molecular_function	nucleus|cytoplasm
YGR200C	YGR200C	ELP2	hom	Verified	1.75254917284477	0.0398397111468415	no	269	0.0548506206441591	260	NA	FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|RNA PROCESSING	NUCLEUS		Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; target of Kluyveromyces lactis zymocin	regulation of transcription from RNA polymerase II promoter|protein urmylation|tRNA wobble uridine modification	molecular_function	Elongator holoenzyme complex|nucleus|cytoplasm
YLL001W	YLL001W	DNM1	hom	Verified	1.74963320491814	0.0400908131181807	no	270	0.0301842339182317	162	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION|PEROXISOME ORGANIZATION	MITOCHONDRION		Dynamin-related GTPase required for mitochondrial fission and morphology; assembles on the cytoplasmic face of mitochondrial tubules at sites at which division will occur; also participates in endocytosis and regulating peroxisome abundance	mitochondrion inheritance|peroxisome fission|mitochondrial fission|chronological cell aging|peroxisome organization|mitochondrion organization|protein homooligomerization	protein homodimerization activity|GTPase activity|identical protein binding	mitochondrial outer membrane|mitochondrion|peroxisome
YPL096C-A	YPL096C-A	ERI1	hom	Verified	1.74838206533682	0.0401989456722746	no	271	0.0645856709897213	344	NA	FT	LIPID METABOLISM|SIGNALING	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Endoplasmic reticulum membrane protein that binds to and inhibits GTP-bound Ras2p at the ER; component of the GPI-GnT complex which catalyzes the first step in GPI-anchor biosynthesis; probable homolog of mammalian PIG-Y protein	GPI anchor biosynthetic process|Ras protein signal transduction	GTPase inhibitor activity	glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex|endoplasmic reticulum membrane
YMR302C	YMR302C	YME2	hom	Verified	1.74567277464324	0.0404339142595988	no	272	0.0428435043345605	250	NA	FT	RNA PROCESSING|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Integral inner mitochondrial membrane protein with a role in maintaining mitochondrial nucleoid structure and number; mutants exhibit an increased rate of mitochondrial DNA escape; shows some sequence similarity to exonucleases	mitochondrial genome maintenance	molecular_function	mitochondrion|integral to mitochondrial inner membrane
YBR129C	YBR129C	OPY1	hom	Verified	1.73859043556309	0.0410534150431385	no	273	0.0239599127699724	128	NA	FT		MITOCHONDRION		Protein of unknown function, overproduction blocks cell cycle arrest in the presence of mating pheromone; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion|cytoplasm
YMR115W	YMR115W	MGR3	hom	Verified	1.73650128501558	0.041237618676997	no	274	0.0364675768082409	173	NA	FT	PROTEOLYSIS	MITOCHONDRION		Subunit of the mitochondrial (mt) i-AAA protease supercomplex, which degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr1p that binds to substrates to facilitate proteolysis; required for growth of cells lacking mtDNA	misfolded or incompletely synthesized protein catabolic process	misfolded protein binding	mitochondrion|mitochondrial inner membrane|i-AAA complex
YHR057C	YHR057C	CPR2	hom	Verified	1.73478792663955	0.0413891877275162	no	275	0.0401345796096162	170	NA					Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; has a potential role in the secretory pathway	biological_process	peptidyl-prolyl cis-trans isomerase activity	cellular_component
YBR020W	YBR020W	GAL1	hom	Verified	1.73334815830011	0.0415169029749623	no	276	0.0381730999668241	212	NA	FT	CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS			Galactokinase; phosphorylates alpha-D-galactose to alpha-D-galactose-1-phosphate in the first step of galactose catabolism; expression regulated by Gal4p; GAL1 has a paralog, GAL3, that arose from the whole genome duplication	galactose catabolic process via UDP-galactose|carbohydrate phosphorylation|positive regulation of transcription by galactose	galactokinase activity	cytoplasm
YOR082C_d	YOR082C	YOR082C	hom	Dubious	1.73163595351928	0.0416692002722718	no	277	0.0336094285354954	175	NA					Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene YOR083W	Unknown	Unknown	Unknown
YLL055W	YLL055W	YCT1	hom	Verified	1.73097221523905	0.0417283600867944	no	278	0.0314002700691697	165	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|PLASMA MEMBRANE		High-affinity cysteine-specific transporter with similarity to the Dal5p family of transporters; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YCT1 is not an essential gene	cysteine transport	ion transmembrane transporter activity|cysteine transmembrane transporter activity	integral to membrane|endoplasmic reticulum
YDR296W	YDR296W	MHR1	hom	Verified	1.7270808041895	0.0420765762672039	no	279	0.0603293049174177	263	NA	FT	MITOCHONDRION ORGANIZATION|RESPONSE TO OXIDATIVE STRESS	NUCLEUS|MITOCHONDRION		Protein involved in homologous recombination in mitochondria; required for recombination-dependent mtDNA partitioning; involved in stimulation of mitochondrial DNA replication in response to oxidative stress	cellular response to oxidative stress|positive regulation of mitochondrial DNA replication|regulation of transcription, DNA-dependent|mitochondrial genome maintenance|DNA recombination	single-stranded DNA binding|recombinase activity|DNA binding	mitochondrion|nucleus
YNR019W	YNR019W	ARE2	hom	Verified	1.72610775591872	0.0421640143862449	no	280	0.0426699178046424	161	NA	FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Acyl-CoA:sterol acyltransferase; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the presence of oxygen; ARE2 has a paralog, ARE1, that arose from the whole genome duplication	ergosterol metabolic process	ergosterol O-acyltransferase activity	integral to membrane|endoplasmic reticulum
YNL072W	YNL072W	RNH201	hom	Verified	1.72219154004205	0.0425174134292972	no	281	0.105589270120928	428	NA	FT		NUCLEUS		Ribonuclease H2 catalytic subunit, removes RNA primers during Okazaki fragment synthesis and errant ribonucleotides misincorporated during DNA replication; homolog of RNAse HI; related to human AGS4 which causes Aicardi-Goutieres syndrome	DNA replication, removal of RNA primer	ribonuclease H activity	ribonuclease H2 complex|nucleus
YJR049C	YJR049C	UTR1	hom	Verified	1.72151845607022	0.0425783930231371	no	282	0.0608098028018295	337	NA	FF|FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS|COFACTOR METABOLISM	NUCLEUS		ATP-NADH kinase; phosphorylates both NAD and NADH; active as a hexamer; enhances the activity of ferric reductase (Fre1p); UTR1 has a paralog, YEF1, that arose from the whole genome duplication	cellular iron ion homeostasis|NADP biosynthetic process	NAD+ kinase activity|NADH kinase activity	nucleus|cytoplasm
YNL055C	YNL055C	POR1	hom	Verified	1.72135534789724	0.042593180824133	no	283	0.0679810185885457	298	NA	FT	ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS	MITOCHONDRION		Mitochondrial porin (voltage-dependent anion channel); outer membrane protein required for the maintenance of mitochondrial osmotic stability and mitochondrial membrane permeability; phosphorylated; protein abundance increases in response to DNA replication stress; POR1 has a paralog, POR2, that arose from the whole genome duplication	DNA transport|mitochondrion organization|apoptotic process|ion transport|cell redox homeostasis	voltage-gated anion channel activity	mitochondrial outer membrane|mitochondrion|integral to mitochondrial outer membrane
YNL303W_d	YNL303W	YNL303W	hom	Dubious	1.72067461350821	0.0426549427706119	no	284	0.0316816094629784	190	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YLR118C	YLR118C	YLR118C	hom	Verified	1.71990351072701	0.0427249911375952	no	285	0.0293341290107285	122	NA	FT	KETONE METABOLISM|LIPID METABOLISM	NUCLEUS		Acyl-protein thioesterase responsible for depalmitoylation of Gpa1p; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus and is induced in response to the DNA-damaging agent MMS	protein deacylation	palmitoyl-(protein) hydrolase activity	nucleus|cytoplasm
YDL117W	YDL117W	CYK3	hom	Verified	1.71870887355536	0.0428336977352361	no	286	0.0433863521322751	215	NA	FT	CELL CYCLE|CELL DIVISION	SITE OF POLARIZED GROWTH|CYTOSKELETON		SH3-domain protein located in the bud neck and cytokinetic actin ring; relocalizes from bud neck to nucleus upon DNA replication stress; activates the chitin synthase activity of Chs2p during cytokinesis; suppressor of growth and cytokinesis defects of chs2 phospho-mutants	barrier septum assembly involved in cell cycle cytokinesis|cytokinesis	molecular_function	cellular bud neck contractile ring|cellular bud neck|cytoplasm
YCL051W	YCL051W	LRE1	hom	Verified	1.7166142680088	0.0430248368894414	no	287	0.0522610783451805	294	NA	FT	CELL WALL ORG/BIOGENESIS			Protein involved in control of cell wall structure and stress response; overproduction confers resistance to cell-wall degrading enzymes; exhibits genetic interactions with genes involved in the cell wall integrity pathway; <br>LRE1 has a paralog, HLR1, that arose from the whole genome duplication	fungal-type cell wall organization	molecular_function	cellular_component
YIL053W	YIL053W	RHR2	hom	Verified	1.71549878504026	0.0431269089777996	no	288	0.0629011830235672	328	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS		Constitutively expressed glycerol-1-phosphatase; involved in glycerol biosynthesis, induced in response to both anaerobic and osmotic stress; RHR2 has a paralog, HOR2, that arose from the whole genome duplication	glycerol biosynthetic process|response to osmotic stress	glycerol-1-phosphatase activity	nucleus|cytoplasm
YOR034C	YOR034C	AKR2	hom	Verified	1.7127930424302	0.0433753102911398	no	289	0.0311415334928113	156	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION	GOLGI APPARATUS		Ankyrin repeat-containing protein; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; possibly involved in constitutive endocytosis of Ste3p; AKR2 has a paralog, AKR1, that arose from the whole genome duplication	endocytosis|protein palmitoylation	palmitoyltransferase activity	integral to membrane|Golgi apparatus
YEL015W	YEL015W	EDC3	hom	Verified	1.70532362962238	0.0440670414646416	no	290	0.0528733264953718	231	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS			Non-essential conserved protein with a role in mRNA decapping; specifically affects the function of the decapping enzyme Dcp1p; localizes to cytoplasmic mRNA processing bodies; forms cytoplasmic foci upon DNA replication stress	deadenylation-independent decapping of nuclear-transcribed mRNA|cytoplasmic mRNA processing body assembly	molecular_function	cytoplasmic mRNA processing body
YDR061W_p	YDR061W	YDR061W	hom	Uncharacterized	1.7037170798568	0.0442169778351603	no	291	0.0459173688872561	204	NA	FT	NUCLEOTIDE METABOLISM	MITOCHONDRION		Protein with similarity to ATP-binding cassette (ABC) transporter family members; lacks predicted membrane-spanning regions; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance	biological_process	molecular_function	mitochondrion
YFR021W	YFR021W	ATG18	hom	Verified	1.70327414434536	0.0442583884406472	no	292	0.0488235145646482	235	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS|PEROXISOME ORGANIZATION|VACUOLAR PROTEIN PROCESSING			Phosphoinositide binding protein; required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; binds both phosphatidylinositol (3,5)-bisphosphate and phosphatidylinositol 3-phosphate; WD-40 repeat protein; relocalizes from vacuole to cytoplasm upon DNA replication stress; has 4 mammalian homologs WIPI1, WIPI2, WIPI3 and WIPI4/WDR45; mutations in human WDR45 cause static encephalopathy of childhood with neurodegeneration in adulthood	piecemeal microautophagy of nucleus|peroxisome degradation|vacuolar protein processing|macroautophagy|late endosome to vacuole transport|CVT pathway	ubiquitin binding|phosphatidylinositol binding	cytosol|endosome|fungal-type vacuole membrane|PAS complex|pre-autophagosomal structure
YER177W	YER177W	BMH1	hom	Verified	1.70269086764959	0.0443129674009707	no	293	0.0519557257101565	298	NA	FT	CELL CYCLE|SIGNALING|RESPONSE TO DNA DAMAGE|CELL WALL ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS		14-3-3 protein, major isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress	glycogen metabolic process|pseudohyphal growth|signal transduction involved in filamentous growth|ascospore formation|fungal-type cell wall chitin biosynthetic process|Ras protein signal transduction|DNA damage checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	DNA replication origin binding|phosphoserine binding	plasma membrane|nucleus
YJR145C	YJR145C	RPS4A	hom	Verified	1.69901032789092	0.044658618835008	no	294	0.0398498430447109	216	NA	FT	TRANSLATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; mutation affects 20S pre-rRNA processing; homologous to mammalian ribosomal protein S4, no bacterial homolog; RPS4A has a paralog, RPS4B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic small ribosomal subunit|cytoplasm|90S preribosome
YNL084C	YNL084C	END3	hom	Verified	1.69800764013794	0.0447531599281252	no	295	0.0737668955672862	353	NA	FF|FT	VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS|CELL DIVISION|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON		EH domain-containing protein involved in endocytosis, actin cytoskeletal organization and cell wall morphogenesis; forms a complex with Sla1p and Pan1p	bipolar cellular bud site selection|ascospore wall assembly|endocytosis|actin filament organization|cytokinesis|actin cortical patch assembly	protein binding, bridging	mating projection tip|actin cortical patch
YOR324C	YOR324C	FRT1	hom	Verified	1.69756640616745	0.0447948138852939	no	296	0.052291118176071	236	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Tail-anchored ER membrane protein of unknown function; substrate of the phosphatase calcineurin; interacts with homolog Frt2p; promotes cell growth in stress conditions, possibly via a role in posttranslational translocation; FRT1 has a paralog, FRT2, that arose from the whole genome duplication	response to stress	molecular_function	endoplasmic reticulum
YGR117C_p	YGR117C	YGR117C	hom	Uncharacterized	1.69535403930121	0.0450041395843699	no	297	0.0264065586973076	108	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	biological_process	molecular_function	cytoplasm
YPL187W	YPL187W	MF(ALPHA)1	hom	Verified	1.69479214624953	0.0450574289412962	no	298	0.0462801164370303	197	NA	FT	SIGNALING			Mating pheromone alpha-factor, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)2, although MF(ALPHA)1 produces most alpha-factor	pheromone-dependent signal transduction involved in conjugation with cellular fusion	mating pheromone activity	extracellular region
YGR051C_d	YGR051C	YGR051C	hom	Dubious	1.69307748641496	0.0452203595028893	no	299	0.036816354239903	182	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YGR051C is not an essential gene	Unknown	Unknown	Unknown
YLR110C	YLR110C	CCW12	hom	Verified	1.69049403154297	0.0454667395713247	no	300	0.098354672686977	458	NA	FF|FT	CELL WALL ORG/BIOGENESIS	SITE OF POLARIZED GROWTH		Cell wall mannoprotein; plays a role in maintenance of newly synthesized areas of cell wall; localizes to periphery of small buds, septum region of larger buds, and shmoo tip; CCW12 has a paralog, YDR134C, that arose from the whole genome duplication	conjugation with cellular fusion|agglutination involved in conjugation with cellular fusion|fungal-type cell wall organization	molecular_function	fungal-type cell wall|mating projection tip|cellular bud tip
YIL114C	YIL114C	POR2	hom	Verified	1.68815590896082	0.0456906522240261	no	301	0.0445301154275127	169	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Putative mitochondrial porin (voltage-dependent anion channel); not required for mitochondrial membrane permeability or mitochondrial osmotic stability; POR2 has a paralog, POR1, that arose from the whole genome duplication	DNA transport|ion transport|cell redox homeostasis	voltage-gated anion channel activity	mitochondrial outer membrane|mitochondrion|integral to membrane
YOR002W	YOR002W	ALG6	hom	Verified	1.68719143220752	0.0457832741651681	no	302	0.0809862759173371	373	NA	FT	LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Alpha 1,3 glucosyltransferase, involved in transfer of oligosaccharides from dolichyl pyrophosphate to asparagine residues of proteins during N-linked protein glycosylation; mutations in human ortholog are associated with disease	oligosaccharide-lipid intermediate biosynthetic process|protein glycosylation|aerobic respiration	transferase activity, transferring hexosyl groups|dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity	integral to membrane|endoplasmic reticulum
YMR193C-A_d	YMR193C-A	YMR193C-A	hom	Dubious	1.68399489490575	0.0460913276758543	no	303	0.0325264935050389	181	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YOL124C	YOL124C	TRM11	hom	Verified	1.68287273226179	0.046199865627351	no	304	0.0431684850505222	239	NA	FT	RNA PROCESSING			Catalytic subunit of an adoMet-dependent tRNA methyltransferase complex (Trm11p-Trm112p), required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs; contains a THUMP domain and a methyltransferase domain	tRNA methylation	S-adenosylmethionine-dependent methyltransferase activity|RNA binding|tRNA (guanine-N2-)-methyltransferase activity	cytoplasm|tRNA (m2G10) methyltransferase complex
YER087C-B	YER087C-B	SBH1	hom	Verified	1.677893521946	0.0466839437044822	no	305	0.076412050598932	311	NA	FT	PROTEIN LOCALIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Beta subunit of the Sec61p ER translocation complex (Sec61p-Sss1p-Sbh1p); involved in protein translocation into the endoplasmic reticulum; interacts with the exocyst complex and also with Rtn1p; homologous to Sbh2p	posttranslational protein targeting to membrane, translocation|SRP-dependent cotranslational protein targeting to membrane, translocation	ARF guanyl-nucleotide exchange factor activity|P-P-bond-hydrolysis-driven protein transmembrane transporter activity	Sec61 translocon complex
YHR123W	YHR123W	EPT1	hom	Verified	1.67771479717422	0.0467013946722219	no	306	0.0310444887876314	164	NA	FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferase; not essential for viability; EPT1 has a paralog, CPT1, that arose from the whole genome duplication	phosphatidylethanolamine biosynthetic process|phosphatidylcholine biosynthetic process	ethanolaminephosphotransferase activity|diacylglycerol cholinephosphotransferase activity	integral to membrane|Golgi apparatus
YDL001W	YDL001W	RMD1	hom	Verified	1.67316988683683	0.04714692832353	no	307	0.0419678097722027	256	NA	FT	CELL CYCLE			Cytoplasmic protein required for sporulation	biological_process	molecular_function	cytoplasm
YHL022C	YHL022C	SPO11	hom	Verified	1.66820330334563	0.0476376876878574	no	308	0.0263188810745334	185	NA	FT	CELL CYCLE	NUCLEUS|CHROMOSOME		Meiosis-specific protein that initiates meiotic recombination by catalyzing the formation of double-strand breaks in DNA via a transesterification reaction; required for homologous chromosome pairing and synaptonemal complex formation	meiotic DNA double-strand break formation	endodeoxyribonuclease activity, producing 3'-phosphomonoesters	nuclear chromosome
YHR140W_p	YHR140W	YHR140W	hom	Uncharacterized	1.66521296724484	0.047935137405227	no	309	0.0350220302656127	183	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Putative integral membrane protein of unknown function	biological_process	molecular_function	integral to membrane
YOR162C	YOR162C	YRR1	hom	Verified	1.66444362494915	0.0480119040989905	no	310	0.0857870650813017	360	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		Zn2-Cys6 zinc-finger transcription factor; activates genes involved in multidrug resistance; paralog of Yrm1p, acting on an overlapping set of target genes; YRR1 has a paralog, PDR8, that arose from the whole genome duplication	regulation of transcription from RNA polymerase II promoter in response to oxidative stress|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity	nucleus
YPR071W_p	YPR071W	YPR071W	hom	Uncharacterized	1.66280201956915	0.048176036126571	no	311	0.0505300025894152	242	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Putative membrane protein; YPR071W is not an essential gene; YPR071W has paralog YIL029C	biological_process	molecular_function	integral to membrane
YLR097C	YLR097C	HRT3	hom	Verified	1.65926757467804	0.048530943067736	no	312	0.0352735428656978	167	NA	FT	PROTEOLYSIS		UBIQUITIN LIGASE COMPLEX	Putative SCF-ubiquitin ligase F-box protein, based on both genetic and physical interactions and sequence similarity; identified in association with Cdc53p, Skp1p and Ubi4 in large and small-scale studies	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|cellular response to methylmercury	ubiquitin-protein ligase activity|protein binding, bridging	SCF ubiquitin ligase complex
YDR162C	YDR162C	NBP2	hom	Verified	1.65874747035606	0.0485833447092436	no	313	0.120774604682163	497	NA	FF|FT	PROTEIN PHOSPHORYLATION	NUCLEUS		Protein involved in the HOG (high osmolarity glycerol) pathway; negatively regulates Hog1p by recruitment of phosphatase Ptc1p the Pbs2p-Hog1p complex; interacts with Bck1p and down regulates the cell wall integrity pathway; found in the nucleus and cytoplasm, contains an SH3 domain and a Ptc1p binding domain (PBM)	negative regulation of protein kinase activity|response to heat|hyperosmotic response	molecular_function	nucleus|cytoplasm
YOR058C	YOR058C	ASE1	hom	Verified	1.65820183654511	0.0486383671147575	no	314	0.0292705880750171	165	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION	NUCLEUS|CYTOSKELETON		Mitotic spindle midzone localized protein; microtubule-associated protein (MAP) family member; required for spindle elongation and stabilization; undergoes cell cycle-regulated degradation by anaphase promoting complex; potential Cdc28p substrate; relative distribution to microtubules decreases upon DNA replication stress	cytokinesis, completion of separation|mitotic anaphase B|microtubule bundle formation|spindle pole body separation|spindle midzone assembly|mitotic spindle stabilization|mitotic spindle elongation	microtubule binding	spindle midzone|nuclear microtubule|spindle
YLR043C	YLR043C	TRX1	hom	Verified	1.65740935066877	0.0487183711043546	no	315	0.0459334493506584	257	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|RESPONSE TO OXIDATIVE STRESS	ENDOMEMBRANE SYSTEM|NUCLEUS|GOLGI APPARATUS		Cytoplasmic thioredoxin isoenzyme; part of the thioredoxin system which protects cells against oxidative and reductive stress; forms LMA1 complex with Pbi2p; acts as a cofactor for Tsa1p, required for ER-Golgi transport and vacuole inheritance; protein abundance increases in response to DNA replication stress	vacuole inheritance|regulation of DNA replication|cell redox homeostasis|protein deglutathionylation|retrograde vesicle-mediated transport, Golgi to ER|cellular response to oxidative stress|ER to Golgi vesicle-mediated transport|vacuole fusion, non-autophagic	disulfide oxidoreductase activity	cytosol|fungal-type vacuole
YIL098C	YIL098C	FMC1	hom	Verified	1.65674737554229	0.0487852802142618	no	316	0.0561931721334612	277	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial matrix protein, required for assembly or stability at high temperature of the F1 sector of mitochondrial F1F0 ATP synthase; null mutant temperature sensitive growth on glycerol is suppressed by multicopy expression of Odc1p	mitochondrial proton-transporting ATP synthase complex assembly	molecular_function	mitochondrion|mitochondrial matrix
YLR382C	YLR382C	NAM2	hom	Verified	1.65585987057586	0.0488750999562798	no	317	0.0624098890718391	272	NA	FT	KETONE METABOLISM|RNA PROCESSING|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial leucyl-tRNA synthetase, also has a direct role in splicing of several mitochondrial group I introns; indirectly required for mitochondrial genome maintenance	Group I intron splicing|leucyl-tRNA aminoacylation|mitochondrial translation	mRNA binding|leucine-tRNA ligase activity	mitochondrion
YBL068W	YBL068W	PRS4	hom	Verified	1.65433740374817	0.049029488601985	no	318	0.0264536179784071	166	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM			5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; PRS4 has a paralog, PRS2, that arose from the whole genome duplication	fungal-type cell wall organization|5-phosphoribose 1-diphosphate biosynthetic process	ribose phosphate diphosphokinase activity	cytoplasm
YDR020C_p	YDR020C	DAS2	hom	Uncharacterized	1.65414989399457	0.0490485303019196	no	319	0.0364320798426937	203	NA	FT	NUCLEOTIDE METABOLISM	NUCLEUS		Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; weak similarity with uridine kinases and with phosphoribokinases	biological_process	molecular_function	nucleus|cytoplasm
YJL176C	YJL176C	SWI3	hom	Verified	1.64731293154692	0.049746870625244	no	320	0.0737421680685877	297	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS	NUCLEUS	RSC COMPLEX	Subunit of the SWI/SNF chromatin remodeling complex; SWI/SNF regulates transcription by remodeling chromosomes; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2; relocates to the cytosol under hypoxic conditions	cellular alcohol catabolic process|ATP-dependent chromatin remodeling|positive regulation of mating type switching|sucrose catabolic process|carbon catabolite activation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter	histone binding|DNA binding	SWI/SNF complex|nucleus
YJR021C	YJR021C	REC107	hom	Verified	1.64711059533236	0.0497676578564771	no	321	0.0477062804394252	232	NA	FT	CELL CYCLE	NUCLEUS|CHROMOSOME		Protein involved in early stages of meiotic recombination; involved in coordination between the initiation of recombination and the first division of meiosis; part of a complex (Rec107p-Mei4p-Rec114p) required for ds break formation	reciprocal meiotic recombination	molecular_function	condensed nuclear chromosome
YJL136C	YJL136C	RPS21B	hom	Verified	1.64692673182028	0.0497865532833862	no	322	0.0533205557251228	235	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21B has a paralog, RPS21A, that arose from the whole genome duplication	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|cytoplasmic translation|endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome	cytosolic small ribosomal subunit
YKL187C	YKL187C	FAT3	hom	Verified	1.64549515417428	0.049933870580221	no	323	0.0351709222069877	167	NA	FT		MITOCHONDRION		Protein required for fatty acid uptake; Fat3p abundance increases in cortical patches in response to oleate exposure; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion|integral to membrane
YNL235C_d	YNL235C	YNL235C	hom	Dubious	1.64248138059577	0.0502451408758964	no	324	0.0707533205708076	328	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SIN4/YNL236W, a subunit of the mediator complex	Unknown	Unknown	Unknown
YKR072C	YKR072C	SIS2	hom	Verified	1.64137391763664	0.0503599103343191	no	325	0.0923410167038334	411	NA	FF|FT	CELL CYCLE|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM	NUCLEUS		Negative regulatory subunit of protein phosphatase 1 Ppz1p and also a subunit of the phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis	regulation of mitotic cell cycle|response to salt stress|coenzyme A biosynthetic process	phosphopantothenoylcysteine decarboxylase activity|protein phosphatase inhibitor activity	phosphopantothenoylcysteine decarboxylase complex|nucleus|cytoplasm
YDL236W	YDL236W	PHO13	hom	Verified	1.6394711575762	0.0505575863577715	no	326	0.0583422059848016	220	NA	FT		NUCLEUS		Alkaline phosphatase specific for p-nitrophenyl phosphate; also has protein phosphatase activity	protein dephosphorylation	4-nitrophenylphosphatase activity|phosphoprotein phosphatase activity|alkaline phosphatase activity	nucleus|cytoplasm
YOR008C-A_p	YOR008C-A	YOR008C-A	hom	Uncharacterized	1.63906962582914	0.0505993800059677	no	327	0.0388094675535102	171	NA					Putative protein of unknown function, includes a potential transmembrane domain; deletion results in slightly lengthened telomeres	biological_process	molecular_function	cellular_component
YBR174C_d	YBR174C	YBR174C	hom	Dubious	1.62744658735948	0.0518211419523747	no	328	0.0569213829915303	298	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YBR175W; null mutant is viable and sporulation defective	Unknown	Unknown	Unknown
YPL087W	YPL087W	YDC1	hom	Verified	1.62680679325839	0.0518890692016782	no	329	0.0401010867851735	222	NA	FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Alkaline dihydroceramidase, involved in sphingolipid metabolism; preferentially hydrolyzes dihydroceramide to a free fatty acid and dihydrosphingosine; has a minor reverse activity; YDC1 has a paralog, YPC1, that arose from the whole genome duplication	ceramide catabolic process|ceramide biosynthetic process	dihydroceramidase activity	integral to membrane|endoplasmic reticulum
YDL201W	YDL201W	TRM8	hom	Verified	1.62656399231128	0.0519148660092625	no	330	0.0355540637994599	162	NA	FT	RNA PROCESSING	NUCLEUS		Noncatalytic subunit of a tRNA methyltransferase complex; Trm8p and Trm82p comprise an enzyme that catalyzes a methyl-transfer from S-adenosyl-l-methionine to the N(7) atom of guanine at position 46 in tRNA; Trm8 lacks catalytic activity if not bound to Trm82p	tRNA methylation	tRNA (guanine-N7-)-methyltransferase activity	tRNA methyltransferase complex|nucleus
YGR004W	YGR004W	PEX31	hom	Verified	1.62642845283243	0.0519292710679375	no	331	0.0364851236055151	198	NA	FT	PEROXISOME ORGANIZATION			Peroxisomal integral membrane protein, involved in negative regulation of peroxisome size; partially functionally redundant with Pex30p and Pex32p; probably acts at a step downstream of steps mediated by Pex28p and Pex29p	peroxisome organization	molecular_function	integral to membrane|integral to peroxisomal membrane
YLR012C_p	YLR012C	YLR012C	hom	Uncharacterized	1.62514845718614	0.0520654649514155	no	332	0.0776456670323507	323	NA					Putative protein of unknown function; YLR012C is not an essential gene	biological_process	molecular_function	cellular_component
YOR183W_p	YOR183W	FYV12	hom	Uncharacterized	1.61922840053385	0.0526990647340043	no	333	0.0556903840062567	284	NA					Protein of unknown function, required for survival upon exposure to K1 killer toxin	biological_process	molecular_function	cellular_component
YMR263W	YMR263W	SAP30	hom	Verified	1.61823565126074	0.052805911208392	no	334	0.0685717062966612	359	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS|CHROMOSOME		Subunit of a histone deacetylase complex, along with Rpd3p and Sin3p, that is involved in silencing at telomeres, rDNA, and silent mating-type loci; involved in telomere maintenance	positive regulation of transcription from RNA polymerase II promoter in response to heat stress|negative regulation of chromatin silencing at silent mating-type cassette|negative regulation of transcription from RNA polymerase I promoter|negative regulation of chromatin silencing at telomere|negative regulation of chromatin silencing at rDNA|positive regulation of transcription from RNA polymerase II promoter	histone deacetylase activity	histone deacetylase complex|Rpd3L-Expanded complex|Rpd3L complex
YOL088C	YOL088C	MPD2	hom	Verified	1.61576960127624	0.053072068134405	no	335	0.0965118965439208	426	NA	FT		ENDOPLASMIC RETICULUM		Member of the protein disulfide isomerase (PDI) family, exhibits chaperone activity; overexpression suppresses the lethality of a pdi1 deletion but does not complement all Pdi1p functions; undergoes oxidation by Ero1p	protein folding	protein disulfide isomerase activity|protein disulfide oxidoreductase activity	endoplasmic reticulum
YGR054W	YGR054W	YGR054W	hom	Verified	1.61536576441828	0.0531157548029647	no	336	0.050392158715606	218	NA	FT	TRANSLATION			Eukaryotic initiation factor (eIF) 2A; associates specifically with both 40S subunits and 80 S ribosomes, and interacts genetically with both eIF5b and eIF4E; homologous to mammalian eIF2A	translational initiation	translation initiation factor activity	cytosolic ribosome|cytosolic small ribosomal subunit|ribosome
YGR174C	YGR174C	CBP4	hom	Verified	1.60924678324225	0.0537811952108924	no	337	0.0485345893339238	236	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial protein required for assembly of cytochrome bc1 complex; interacts with the Cbp3p-Cbp6p complex and newly synthesized cytochrome b (Cobp) to promote assembly of Cobp into the cytochrome bc1 complex	mitochondrial respiratory chain complex III assembly	molecular_function	mitochondrion|integral to mitochondrial membrane
YCR016W_p	YCR016W	YCR016W	hom	Uncharacterized	1.60821875634063	0.0538936383415973	no	338	0.0347920874213366	199	NA	FT		NUCLEUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus and nucleus; predicted to be involved in ribosome biogenesis	biological_process	molecular_function	nucleolus|nucleus
YOR006C	YOR006C	TSR3	hom	Verified	1.5992219215664	0.0548856505441578	no	339	0.0780831153260012	334	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Protein required for 20S pre-rRNA processing; involved in processing of the 20S pre-rRNA at site D to generate mature 18S rRNA; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; relative distribution to the nucleus increases upon DNA replication stress	maturation of SSU-rRNA	molecular_function	nucleus|cytoplasm
YGR154C	YGR154C	GTO1	hom	Verified	1.59550431530125	0.0552997528907443	no	340	0.0504076542120663	221	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS			Omega-class glutathione transferase; induced under oxidative stress; putative peroxisomal localization	glutathione metabolic process	glutathione transferase activity	peroxisome
YBL022C	YBL022C	PIM1	hom	Verified	1.59460256204997	0.0554005696604876	no	341	0.0893157152406134	383	NA	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS|MITOCHONDRION ORGANIZATION|RESPONSE TO OXIDATIVE STRESS	MITOCHONDRION		ATP-dependent Lon protease, involved in degradation of misfolded proteins in mitochondria; required for biogenesis and maintenance of mitochondria	chaperone-mediated protein complex assembly|misfolded or incompletely synthesized protein catabolic process	ATP-dependent peptidase activity	mitochondrion|mitochondrial matrix
YCL038C	YCL038C	ATG22	hom	Verified	1.59430865573138	0.0554334599742626	no	342	0.0481044722595261	222	NA	FT	PROTEIN LOCALIZATION|VACUOLAR TRANSPORT			Vacuolar integral membrane protein required for efflux of amino acids during autophagic body breakdown in the vacuole; null mutation causes a gradual loss of viability during starvation	amino acid export from vacuole	molecular_function	integral to fungal-type vacuolar membrane|integral to membrane
YER051W	YER051W	JHD1	hom	Verified	1.59230144318694	0.0556584944192955	no	343	0.0539543407329221	225	NA	FT	CHROMATIN ORGANIZATION|OXIDATION-REDUCTION PROCESS	NUCLEUS		JmjC domain family histone demethylase specific for H3-K36, similar to proteins found in human, mouse, drosophila, X. laevis, C. elegans, and S. pombe	histone demethylation	methylated histone residue binding|histone demethylase activity (H3-K36 specific)	cellular_component
YNL184C_p	YNL184C	YNL184C	hom	Uncharacterized	1.59089170007572	0.0558169753930146	no	344	0.0767123545093113	333	NA					Protein of unknown function; expressed at both mRNA and protein levels	biological_process	molecular_function	cellular_component
YAL040C	YAL040C	CLN3	hom	Verified	1.58704672647191	0.0562510310824575	no	345	0.0523200113231412	287	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|MEMBRANE ORGANIZATION|CELL DIVISION|PROTEIN PHOSPHORYLATION	NUCLEUS		G1 cyclin involved in cell cycle progression; activates Cdc28p kinase to promote the G1 to S phase transition; plays a role in regulating transcription of the other G1 cyclins, CLN1 and CLN2; regulated by phosphorylation and proteolysis	vacuole organization|regulation of cyclin-dependent protein kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|vacuole fusion, non-autophagic|regulation of cell size|G1/S transition of mitotic cell cycle	cyclin-dependent protein kinase regulator activity	nucleus
YCR081W	YCR081W	SRB8	hom	Verified	1.58676212974916	0.0562832644382388	no	346	0.0679833394303313	336	NA	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; involved in glucose repression	negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription by galactose|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II transcription coactivator activity	mediator complex
YNL212W	YNL212W	VID27	hom	Verified	1.58602241468116	0.0563671124980766	no	347	0.0552234570390877	261	NA					Cytoplasmic protein of unknown function; possibly involved in vacuolar protein degradation; not essential for proteasome-dependent degradation of fructose-1,6-bisphosphatase (FBPase); null mutants exhibit normal growth	biological_process	molecular_function	cytoplasm
YPL225W	YPL225W	YPL225W	hom	Verified	1.57877854854665	0.0571934303039004	no	348	0.071884334991523	320	NA					Protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	ribosome|cytoplasm
YKL191W	YKL191W	DPH2	hom	Verified	1.57763013840086	0.0573253021854268	no	349	0.0454194052596312	222	NA					Protein required, along with Dph1p, Kti11p, Jjj3p, and Dph5p, for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); may act in a complex with Dph1p and Kti11p	peptidyl-diphthamide biosynthetic process from peptidyl-histidine	molecular_function	cytoplasm
YKL126W	YKL126W	YPK1	hom	Verified	1.57756608844613	0.0573326640768381	no	350	0.226419327463971	862	NA	FF|FT	VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS|PROTEIN PHOSPHORYLATION	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Serine/threonine protein kinase; phosphorylates and downregulates flippase activator Fpk1p; inactivates Orm1p and Orm2p (inhibitors of serine:palmitoyl-coenzyme A transferase) by phosphorylation in response to compromised sphingolipid synthesis; mutations affect receptor-mediated endocytosis and sphingolipid-mediated and cell integrity signaling pathways; homolog of mammalian kinase SGK; YPK1 has a paralog, YPK2, that arose from the whole genome duplication	eisosome assembly|protein autophosphorylation|negative regulation of phospholipid translocation|protein phosphorylation	protein serine/threonine kinase activity	cytosol|plasma membrane|cellular bud neck
YLR202C_d	YLR202C	YLR202C	hom	Dubious	1.57632604638084	0.0574753409854871	no	351	0.0537087047920104	278	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YLR201C; ORF contains a putative intron	Unknown	Unknown	Unknown
YPL114W_d	YPL114W	YPL114W	hom	Dubious	1.57575192020263	0.0575414933902818	no	352	0.0536934983509347	256	NA					Dubious open reading frame, unlikely to encode a functional protein; largely overlaps ORF YPL113C; diploid deletion in BY4743 strain background exhibits high budding index	Unknown	Unknown	Unknown
YCR068W	YCR068W	ATG15	hom	Verified	1.57326934567463	0.0578282321042567	no	353	0.0767455693098038	352	NA	FT	LIPID METABOLISM|MEMBRANE ORGANIZATION|VACUOLAR PROTEIN PROCESSING	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Lipase required for intravacuolar lysis of autophagic bodies and Cvt bodies; targeted to intravacuolar vesicles during autophagy via the multivesicular body (MVB) pathway	membrane disassembly|autophagy|piecemeal microautophagy of nucleus|vacuolar protein processing|multivesicular body membrane disassembly	lipase activity	integral to membrane|vacuolar lumen
YNR060W	YNR060W	FRE4	hom	Verified	1.57059744027147	0.0581380924627148	no	354	0.0532743569278025	286	NA	FT	ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|GEN. OF PRECURSOR METABOLITES AND ENERGY	PLASMA MEMBRANE		Ferric reductase, reduces a specific subset of siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels	siderophore transport	ferric-chelate reductase activity	integral to membrane|plasma membrane
YDL191W	YDL191W	RPL35A	hom	Verified	1.56881288349784	0.0583457727611935	no	355	0.0581530126959043	300	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L35A; homologous to mammalian ribosomal protein L35 and bacterial L29; RPL35A has a paralog, RPL35B, that arose from the whole genome duplication	cytoplasmic translation|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome	cytosolic large ribosomal subunit|preribosome, large subunit precursor
YJR018W_d	YJR018W	YJR018W	hom	Dubious	1.56734054522929	0.0585175565050175	no	356	0.0652910052565123	336	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YNL092W_p	YNL092W	YNL092W	hom	Uncharacterized	1.56673718371798	0.058588067779997	no	357	0.0446523747436357	167	NA					Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; YNL092W is not an essential gene	biological_process	S-adenosylmethionine-dependent methyltransferase activity	cellular_component
YNL168C_p	YNL168C	FMP41	hom	Uncharacterized	1.56615308975064	0.0586563908973491	no	358	0.0453545488998404	237	NA	FT		MITOCHONDRION		Putative protein of unknown function; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YML048W	YML048W	GSF2	hom	Verified	1.56107633741886	0.0592528702122832	no	359	0.089601544430173	401	NA	FF|FT	PROTEIN LOCALIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION		ER localized integral membrane protein that may promote secretion of certain hexose transporters, including Gal2p; involved in glucose-dependent repression	protein folding|protein localization to cell surface	unfolded protein binding	mitochondrial outer membrane|integral to endoplasmic reticulum membrane|cytoplasm
YNL111C	YNL111C	CYB5	hom	Verified	1.55790968487512	0.0596273295307958	no	360	0.104066532779434	430	NA	FF|FT	LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Cytochrome b5, involved in the sterol and lipid biosynthesis pathways; acts as an electron donor to support sterol C5-6 desaturation	sterol biosynthetic process	electron carrier activity	endoplasmic reticulum membrane
YPR179C	YPR179C	HDA3	hom	Verified	1.55412701980921	0.0600770606277195	no	361	0.0591927104257941	299	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|CHROMOSOME SEGREGATION|GENE SILENCING	NUCLEUS|CHROMOSOME		Subunit of a possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex that contains an Hda1p homodimer and an Hda2p-Hda3p heterodimer; required for the activity of the complex; has similarity to Hda2p	negative regulation of transcription from RNA polymerase II promoter|chromosome segregation|gene silencing by RNA|gene silencing involved in chronological cell aging|histone deacetylation	histone deacetylase activity|chromatin binding|DNA binding	nucleus|HDA1 complex
YIL027C	YIL027C	EMC5	hom	Verified	1.55308046298981	0.0602019564632029	no	362	0.0769452194771955	336	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response, and also shows K1 killer toxin resistance; homologous to worm B0334.15/EMC-5, fly CG15168, human MMGT	protein folding in endoplasmic reticulum	molecular_function	ER membrane protein complex|endoplasmic reticulum
YMR256C	YMR256C	COX7	hom	Verified	1.54870570177941	0.060726241304945	no	363	0.0852459343453278	342	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Subunit VII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain	mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity	mitochondrion|integral to membrane|mitochondrial respiratory chain complex IV
YHL027W	YHL027W	RIM101	hom	Verified	1.54741987214473	0.0608810162022529	no	364	0.10419484508603	470	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|ION HOMEOSTASIS|CELL WALL ORG/BIOGENESIS|CELL DIVISION|ION HOMEOSTASIS	NUCLEUS		Cys2His2 zinc-finger transcriptional repressor; involved in alkaline responsive gene repression as part of adaptation to a alkaline conditions; involved in cell wall assembly; required for alkaline pH-stimulated haploid invasive growth and sporulation; activated by alkaline-dependent proteolytic processing which results in removal of the C-terminal tail; similar to A. nidulans PacC	meiosis|negative regulation of transcription from RNA polymerase II promoter|fungal-type cell wall biogenesis|cellular response to anoxia|response to pH|ascospore formation|barrier septum assembly|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|sequence-specific DNA binding	nucleus
YOL154W	YOL154W	ZPS1	hom	Verified	1.54683842057774	0.0609511065342603	no	365	0.0408393967938788	179	NA					Putative GPI-anchored protein; transcription is induced under low-zinc conditions, as mediated by the Zap1p transcription factor, and at alkaline pH	biological_process	molecular_function	fungal-type cell wall|fungal-type vacuole
YLR363W-A	YLR363W-A	YLR363W-A	hom	Verified	1.54441687939122	0.0612436867469042	no	366	0.0388979434854109	224	NA	FT		NUCLEUS		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; relocalizes from nucleus to nucleolus upon DNA replication stress	biological_process	molecular_function	nucleus
YBR292C_d	YBR292C	YBR292C	hom	Dubious	1.54419249297138	0.0612708534654702	no	367	0.0575249096713166	324	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR292C is not an essential gene	Unknown	Unknown	Unknown
YGR061C	YGR061C	ADE6	hom	Verified	1.53115587777337	0.0628654362592561	no	368	0.0712994671661473	274	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEOTIDE METABOLISM			Formylglycinamidine-ribonucleotide (FGAM)-synthetase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway	'de novo' IMP biosynthetic process|purine nucleotide biosynthetic process	phosphoribosylformylglycinamidine synthase activity	cytoplasm
YGL224C	YGL224C	SDT1	hom	Verified	1.52609003477391	0.0634937217485283	no	369	0.059155569063651	292	NA					Pyrimidine nucleotidase; overexpression suppresses the 6-AU sensitivity of transcription elongation factor S-II, as well as resistance to other pyrimidine derivatives	pyrimidine nucleobase metabolic process	nucleotidase activity	cellular_component
YJL003W	YJL003W	COX16	hom	Verified	1.52606745382363	0.0634965332254573	no	370	0.0616664394078375	244	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial inner membrane protein, required for assembly of cytochrome c oxidase	mitochondrial respiratory chain complex IV assembly	molecular_function	mitochondrion|mitochondrial inner membrane
YPL064C	YPL064C	CWC27	hom	Verified	1.52507643004663	0.063620017667539	no	371	0.0751230249723803	306	NA	FT	RNA PROCESSING	NUCLEUS		Component of a complex containing Cef1p; putatively involved in pre-mRNA splicing; has similarity to S. pombe Cwf27p; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	U2-type spliceosomal complex
YDR494W	YDR494W	RSM28	hom	Verified	1.52501689407751	0.0636274419679479	no	372	0.0681880055938019	335	NA	FT	TRANSLATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the small subunit; genetic interactions suggest a possible role in promoting translation initiation	cytoplasmic translation|translational initiation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YBR107C	YBR107C	IML3	hom	Verified	1.52078962902556	0.0641563189095078	no	373	0.0506226849013488	277	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME	KINETOCHORE	Outer kinetochore protein and component of the Ctf19 complex; involved in the establishment of pericentromeric cohesion during mitosis; prevents non-disjunction of sister chromatids during meiosis II; required for localization of Sgo1p to pericentric sites during meiosis I; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-L and fission yeast fta1	establishment of meiotic sister chromatid cohesion|ascospore formation|protein localization to chromosome, centromeric region|meiotic sister chromatid segregation|maintenance of meiotic sister chromatid cohesion|establishment of mitotic sister chromatid cohesion	molecular_function	condensed nuclear chromosome outer kinetochore
YOL032W	YOL032W	OPI10	hom	Verified	1.52054480933565	0.0641870528947782	no	374	0.0503531036130357	225	NA	FT	LIPID METABOLISM|CARBOHYDRATE METABOLISM	NUCLEUS		Protein with a possible role in phospholipid biosynthesis; null mutant displays an inositol-excreting phenotype that is suppressed by exogenous choline; protein abundance increases in response to DNA replication stress	inositol metabolic process	molecular_function	nucleus|cytoplasm
YDR323C	YDR323C	PEP7	hom	Verified	1.51922095461994	0.0643534442498157	no	375	0.129155381858056	541	NA	FF|FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT			Multivalent adaptor protein that facilitates vesicle-mediated vacuolar protein sorting by ensuring high-fidelity vesicle docking and fusion, which are essential for targeting of vesicles to the endosome; required for vacuole inheritance	Golgi to vacuole transport|vacuole inheritance|vesicle fusion|vesicle docking involved in exocytosis|Golgi to endosome transport	phosphatidylinositol-3-phosphate binding	external side of endosome membrane|cytoplasm
YNL203C_d	YNL203C	YNL203C	hom	Dubious	1.51898456012231	0.0643831912081432	no	376	0.0684900871583501	352	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YIL107C	YIL107C	PFK26	hom	Verified	1.51554708829364	0.064816957488215	no	377	0.0745897787019983	302	NA	FT	CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY			6-phosphofructo-2-kinase, inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate; has negligible fructose-2,6-bisphosphatase activity; transcriptional regulation involves protein kinase A	regulation of glycolysis|fructose 2,6-bisphosphate metabolic process	6-phosphofructo-2-kinase activity	cytoplasm
YIL020C	YIL020C	HIS6	hom	Verified	1.51523843619693	0.0648560163037986	no	378	0.0681909869800228	294	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Phosphoribosyl-5-amino-1-phosphoribosyl-4-imidazolecarboxiamide isomerase, catalyzes the fourth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts	histidine biosynthetic process	1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity	intracellular
YHR139C-A_d	YHR139C-A	YHR139C-A	hom	Dubious	1.50938307173344	0.0656004582852371	no	379	0.057422309443658	289	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YKL044W_p	YKL044W	YKL044W	hom	Uncharacterized	1.50621814230665	0.0660055918082998	no	380	0.0530356728223998	246	NA					Protein of unknown function; mRNA identified as translated by ribosome profiling data	biological_process	molecular_function	cellular_component
YIR036C_p	YIR036C	IRC24	hom	Uncharacterized	1.50541456304364	0.0661087636417793	no	381	0.0676654925636616	298	NA	FT	OXIDATION-REDUCTION PROCESS			Putative benzil reductase;(GFP)-fusion protein localizes to the cytoplasm and is induced by the DNA-damaging agent MMS; sequence similarity with short-chain dehydrogenase/reductases; null mutant has increased spontaneous Rad52p foci	biological_process	molecular_function	integral to membrane|cytoplasm
YNL201C	YNL201C	PSY2	hom	Verified	1.50287862101785	0.0664351734834216	no	382	0.0805232930897116	328	NA	FT	CELL CYCLE|SIGNALING|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Subunit of protein phosphatase PP4 complex; active complex is composed of catalytic subunit Pph3p and Psy2p, with Psy4p apparently providing additional substrate specificity in some cases; regulates recovery from the DNA damage checkpoint and also the gene conversion- and single-strand annealing-mediated pathways of meiotic double-strand break repair; Pph3p and Psy2p localize to foci on meiotic chromosomes; putative homolog of mammalian R3	Unknown|response to DNA damage stimulus|protein dephosphorylation|signal transduction involved in meiotic recombination checkpoint	protein serine/threonine phosphatase activity	condensed nuclear chromosome|nucleus
YPL174C	YPL174C	NIP100	hom	Verified	1.50171297386764	0.0665856259070227	no	383	0.0810465089014474	368	NA	FT	CELL CYCLE|CYTOSKELETON ORGANIZATION	CYTOSKELETON		Large subunit of the dynactin complex, which is involved in partitioning the mitotic spindle between mother and daughter cells; putative ortholog of mammalian p150(glued)	establishment of mitotic spindle orientation	microtubule binding	dynactin complex|cell cortex|spindle pole body|astral microtubule
YHR103W	YHR103W	SBE22	hom	Verified	1.5015804389147	0.0666027491445154	no	384	0.069337409493425	294	NA	FT	PROTEIN LOCALIZATION|CELL WALL ORG/BIOGENESIS	GOLGI APPARATUS		Protein involved in the transport of cell wall components from the Golgi to the cell surface; similar in structure and functionally redundant with Sbe2p; involved in bud growth	fungal-type cell wall organization	molecular_function	cytoplasm
YDR383C	YDR383C	NKP1	hom	Verified	1.50138592341238	0.0666278863103221	no	385	0.0710622388592991	284	NA	FT	CELL CYCLE|CELL DIVISION	NUCLEUS|CHROMOSOME	KINETOCHORE	Central kinetochore protein and subunit of the Ctf19 complex; mutants have elevated rates of chromosome loss; orthologous to fission yeast kinetochore protein fta4	biological_process	molecular_function	kinetochore
YER120W	YER120W	SCS2	hom	Verified	1.50123732713355	0.0666470942988244	no	386	0.0634769816383334	334	NA	FT	PROTEIN LOCALIZATION|LIPID METABOLISM|GENE SILENCING	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|SITE OF POLARIZED GROWTH		Integral ER membrane protein, regulates phospholipid metabolism; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PI4P levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; interacts with FFAT motif of Opi1p; involved in telomeric silencing; null shows inositol auxotrophy above 34 deg C; VAP homolog; SCS2 has a paralog, SCS22, that arose from the whole genome duplication	endoplasmic reticulum inheritance|regulation of intracellular lipid transport|negative regulation of transcription factor import into nucleus|phospholipid biosynthetic process|chromatin silencing at telomere	phosphatidylinositol binding|FFAT motif binding	nuclear membrane|integral to endoplasmic reticulum membrane|nuclear envelope|endoplasmic reticulum|cellular bud tip
YMR252C_p	YMR252C	YMR252C	hom	Uncharacterized	1.5010015197928	0.0666775842398511	no	387	0.0512848212429319	267	NA	FT		MITOCHONDRION		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YMR252C is not an essential gene	biological_process	molecular_function	mitochondrion
YLR384C	YLR384C	IKI3	hom	Verified	1.50016142804722	0.0667862960275213	no	388	0.0612490604569849	299	NA	FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|RNA PROCESSING	NUCLEUS		Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator; homolog of human IKAP, mutations in which cause familial dysautonomia (FD)	regulation of transcription from RNA polymerase II promoter|tRNA wobble uridine modification	molecular_function	Elongator holoenzyme complex|nucleus|cytoplasm
YDR431W_d	YDR431W	YDR431W	hom	Dubious	1.49713682887436	0.0671788292564962	no	389	0.0452474288697094	224	NA					Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YBR181C	YBR181C	RPS6B	hom	Verified	1.49618039405188	0.0673033261369878	no	390	0.0662409371973704	285	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S6, no bacterial homolog; RPS6B has a paralog, RPS6A, that arose from the whole genome duplication	cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome	small-subunit processome|cytosolic small ribosomal subunit|cytoplasm
YML089C_d	YML089C	YML089C	hom	Dubious	1.49572839474372	0.0673622238552944	no	391	0.0616088409897986	212	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; expression induced by calcium shortage	Unknown	Unknown	Unknown
YHR044C	YHR044C	DOG1	hom	Verified	1.49414763874003	0.0675685174256976	no	392	0.0497010259650751	243	NA	FT	CARBOHYDRATE METABOLISM			2-deoxyglucose-6-phosphate phosphatase; paralogous to DOG2; member of a family of low molecular weight phosphatases; confers 2-deoxyglucose resistance when overexpressed, in vivo substrate has not yet been identified	glucose metabolic process	2-deoxyglucose-6-phosphatase activity	cellular_component
YLR361C	YLR361C	DCR2	hom	Verified	1.49409033227293	0.0675760052567531	no	393	0.0509399613863765	217	NA	FT	CELL CYCLE|SIGNALING			Phosphoesterase involved in downregulation of the unfolded protein response, at least in part via dephosphorylation of Ire1p; dosage-dependent positive regulator of the G1/S phase transition through control of the timing of START	endoplasmic reticulum unfolded protein response|traversing start control point of mitotic cell cycle|protein dephosphorylation	hydrolase activity, acting on ester bonds|phosphoprotein phosphatase activity|phosphoric ester hydrolase activity	cellular_component
YDR110W	YDR110W	FOB1	hom	Verified	1.4923776610554	0.0678000839454224	no	394	0.0603117396942144	221	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|CHROMATIN ORGANIZATION|CHROMOSOME SEGREGATION|GENE SILENCING	NUCLEUS|CHROMOSOME		Nucleolar protein that binds the rDNA replication fork barrier (RFB) site; required for replication fork blocking, recombinational hotspot activity, condensin recruitment to RFB and rDNA repeat segregation; related to retroviral integrases	extrachromosomal circular DNA accumulation involved in cell aging|negative regulation of DNA replication|rDNA condensation|chromatin silencing at rDNA|replicative cell aging|protein localization to nucleolar rDNA repeats|DNA recombination	rDNA spacer replication fork barrier binding	nucleolus|rDNA heterochromatin
YLR146C	YLR146C	SPE4	hom	Verified	1.48245074507329	0.069110200089805	no	395	0.0584738651610982	266	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM			Spermine synthase, required for the biosynthesis of spermine and also involved in biosynthesis of pantothenic acid	pantothenate biosynthetic process|spermine biosynthetic process	spermine synthase activity	cytoplasm
YMR194W	YMR194W	RPL36A	hom	Verified	1.47917375989638	0.0695469403561785	no	396	0.0600413752162553	305	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L36A; N-terminally acetylated; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L36, no bacterial homolog; RPL36A has a paralog, RPL36B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome|RNA binding	cytosolic large ribosomal subunit
YNR031C	YNR031C	SSK2	hom	Verified	1.47303647433288	0.070370600494501	no	397	0.0677591157910296	304	NA	FT	SIGNALING|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION	SITE OF POLARIZED GROWTH		MAP kinase kinase kinase of the HOG1 mitogen-activated signaling pathway; interacts with Ssk1p, leading to autophosphorylation and activation of Ssk2p which phosphorylates Pbs2p; also mediates actin cytoskeleton recovery from osmotic stress	MAPK cascade involved in osmosensory signaling pathway|protein autophosphorylation|protein phosphorylation|response to osmotic stress|actin cytoskeleton organization|osmosensory signaling pathway via two-component system	MAP kinase kinase kinase activity	cytosol|cellular bud neck|cellular bud tip
YLR413W_p	YLR413W	YLR413W	hom	Uncharacterized	1.46993814756927	0.0707892533087478	no	398	0.0651672528522871	288	NA	FT		PLASMA MEMBRANE		Putative protein of unknown function; YLR413W is not an essential gene	biological_process	molecular_function	integral to membrane
YOL046C_d	YOL046C	YOL046C	hom	Dubious	1.46404150101587	0.0715913046730597	no	399	0.056467240843042	250	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data;almost completely overlaps the verified gene PSK2/YOL045W	Unknown	Unknown	Unknown
YPL051W	YPL051W	ARL3	hom	Verified	1.46194023680818	0.0718787937831482	no	400	0.108536404590799	470	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		GTPase of the Ras superfamily required to recruit Arl1p to the Golgi; similar to ADP-ribosylation factor	intracellular protein transport|Golgi to plasma membrane protein transport|protein localization to organelle	GTPase activity	Golgi apparatus|nuclear outer membrane-endoplasmic reticulum membrane network
YPL115C	YPL115C	BEM3	hom	Verified	1.45644844358123	0.0726343460347656	no	401	0.0985528861140185	427	NA	FT	SIGNALING	SITE OF POLARIZED GROWTH		Rho GTPase activating protein (RhoGAP) involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assembly	negative regulation of Rho protein signal transduction|establishment of cell polarity	Rho GTPase activator activity|phosphatidylinositol-3-phosphate binding	cell cortex|incipient cellular bud site|mating projection tip|cytoplasm|cellular bud tip
YMR223W	YMR223W	UBP8	hom	Verified	1.45620337690194	0.0726682031516537	no	402	0.0588327138958752	293	NA	FT	CHROMATIN ORGANIZATION|PROTEOLYSIS	NUCLEUS	HISTONE ACETYLTRANSFERASE	Ubiquitin-specific protease that is a component of the SAGA (Spt-Ada-Gcn5-Acetyltransferase) acetylation complex; required for SAGA-mediated deubiquitination of histone H2B	histone H3-K4 methylation|histone deubiquitination|histone H3-K79 methylation	ubiquitin-specific protease activity|protein complex scaffold	DUBm complex|SLIK (SAGA-like) complex|SAGA complex
YMR316C-B_d	YMR316C-B	YMR316C-B	hom	Dubious	1.45609571732554	0.0726830806500097	no	403	0.0432450798488207	241	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDR149C_d	YDR149C	YDR149C	hom	Dubious	1.45138861021269	0.0733358397526295	no	404	0.0711017593888955	338	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene NUM1; null mutation blocks anaerobic growth	Unknown	Unknown	Unknown
YPL140C	YPL140C	MKK2	hom	Verified	1.45043655766983	0.0734684093897795	no	405	0.0723319992324028	276	NA	FT	SIGNALING|PROTEIN PHOSPHORYLATION|PEROXISOME ORGANIZATION			MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk1p; MKK2 has a paralog, MKK1, that arose from the whole genome duplication	signal transduction|peroxisome degradation|protein phosphorylation	MAP kinase kinase activity	intracellular
YKL222C	YKL222C	YKL222C	hom	Verified	1.4484333092428	0.0737479524082973	no	406	0.0760204731571858	329	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS|CYTOSKELETON		Protein of unknown function that may interact with ribosomes, based on co-purification experiments; similar to transcriptional regulators from the zinc cluster (binuclear cluster) family; null mutant is sensitive to caffeine	biological_process	sequence-specific DNA binding	ribosome|nucleus|mitotic spindle
YJR066W	YJR066W	TOR1	hom	Verified	1.44611205946486	0.0740728869065253	no	407	0.0585165559399739	270	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RIBOSOME BIOGENESIS|SIGNALING|RESPONSE TO DNA DAMAGE|CELL WALL ORG/BIOGENESIS	ENDOMEMBRANE SYSTEM|NUCLEUS|GOLGI APPARATUS|PLASMA MEMBRANE		PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis; TOR1 has a paralog, TOR2, that arose from the whole genome duplication	regulation of cell cycle|G1 phase of mitotic cell cycle|transcription of nuclear large rRNA transcript from RNA polymerase I promoter|regulation of cell growth|response to DNA damage stimulus|mitochondria-nucleus signaling pathway|ribosome biogenesis|meiosis|signal transduction|TOR signaling cascade|fungal-type cell wall organization|negative regulation of autophagy	protein binding|protein kinase activity	TORC1 complex|fungal-type vacuole membrane|endosome membrane|extrinsic to internal side of plasma membrane|plasma membrane|nucleus|Golgi membrane|cytoplasm
YJR153W	YJR153W	PGU1	hom	Verified	1.44286784010454	0.0745288520510049	no	408	0.0616663916112305	228	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM			Endo-polygalacturonase, pectolytic enzyme that hydrolyzes the alpha-1,4-glycosidic bonds in the rhamnogalacturonan chains in pectins	pseudohyphal growth|pectin catabolic process	polygalacturonase activity	extracellular region
YPR184W	YPR184W	GDB1	hom	Verified	1.44070312567092	0.0748342857463341	no	409	0.0746136594874677	353	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS|MITOCHONDRION		Glycogen debranching enzyme; contains glucanotranferase and alpha-1,6-amyloglucosidase activities; required for glycogen degradation; phosphorylated in mitochondria; activity is inhibited by Igd1p; protein abundance increases in response to DNA replication stress	glycogen catabolic process	4-alpha-glucanotransferase activity|amylo-alpha-1,6-glucosidase activity	mitochondrion|cytoplasm
YGL064C	YGL064C	MRH4	hom	Verified	1.43956192076909	0.0749956897558313	no	410	0.0853180543780264	347	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS	MITOCHONDRION		Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function	RNA metabolic process	RNA helicase activity	mitochondrion
YOL045W	YOL045W	PSK2	hom	Verified	1.43709731183334	0.075345172477049	no	411	0.091642446626223	322	NA	FT	SIGNALING|TRANSLATION|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		PAS-domain containing serine/threonine protein kinase; regulates sugar flux and translation in response to an unknown metabolite by phosphorylating Ugp1p and Gsy2p (sugar flux) and Caf20p, Tif11p and Sro9p (translation); PSK2 has a paralog, PSK1, that arose from the whole genome duplication	regulation of (1->6)-beta-D-glucan biosynthetic process|negative regulation of glycogen biosynthetic process|protein phosphorylation	protein serine/threonine kinase activity	mitochondrion|cytoplasm
YJL128C	YJL128C	PBS2	hom	Verified	1.43697023897898	0.0753632250642543	no	412	0.102942085968338	454	NA	FF|FT	PROTEIN LOCALIZATION|SIGNALING|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION	SITE OF POLARIZED GROWTH		MAP kinase kinase of the HOG signaling pathway; activated under severe osmotic stress; mitophagy-specific regulator; plays a role in regulating Ty1 transposition	activation of MAPK activity involved in osmosensory signaling pathway|actin filament organization|MAPK import into nucleus involved in osmosensory signaling pathway|protein phosphorylation|hyperosmotic response|osmosensory signaling pathway|cellular response to heat	MAP-kinase scaffold activity|MAP kinase kinase activity|protein kinase activity	cellular bud neck|cytoplasm|cellular bud tip
YBR163W	YBR163W	EXO5	hom	Verified	1.43649309818617	0.0754310394358968	no	413	0.0844747574041231	411	NA	FT	MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial 5'-3' exonuclease and sliding exonuclease, required for mitochondrial genome maintenance; distantly related to the RecB nuclease domain of bacterial RecBCD recombinases; may be regulated by the transcription factor Ace2	mitochondrial genome maintenance	single-stranded DNA specific 5'-3' exodeoxyribonuclease activity	mitochondrion
YHR041C	YHR041C	SRB2	hom	Verified	1.43591327207747	0.0755135107011891	no	414	0.114188604022527	420	NA	FT	TRANSCRIPTION FROM RNA POL II|RIBOSOME BIOGENESIS|RESPONSE TO NUTRIENT LEVELS	NUCLEUS	RNA POL II, HOLOENZYME	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; general transcription factor involved in telomere maintenance	negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter in response to chemical stimulus|RNA polymerase II transcriptional preinitiation complex assembly|negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter in response to nutrient levels|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly|core RNA polymerase II binding transcription factor activity|RNA polymerase II transcription factor recruiting transcription factor activity|TBP-class protein binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly|protein domain specific binding	core mediator complex
YDR284C	YDR284C	DPP1	hom	Verified	1.43549206810543	0.0755734635024315	no	415	0.0712520227687723	301	NA	FT	LIPID METABOLISM|SIGNALING			Diacylglycerol pyrophosphate (DGPP) phosphatase, zinc-regulated vacuolar membrane-associated lipid phosphatase, dephosphorylates DGPP to phosphatidate (PA) and Pi, then PA to diacylglycerol; involved in lipid signaling and cell metabolism	phospholipid metabolic process|signal transduction	diacylglycerol diphosphate phosphatase activity|phosphatidate phosphatase activity	fungal-type vacuole membrane|integral to membrane
YOR271C_p	YOR271C	FSF1	hom	Uncharacterized	1.43510654056221	0.0756283700203725	no	416	0.0683592025735233	290	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Putative protein, predicted to be an alpha-isopropylmalate carrier; belongs to the sideroblastic-associated protein family; non-tagged protein is detected in purified mitochondria; likely to play a role in iron homeostasis	biological_process	molecular_function	mitochondrion|integral to membrane
YDL173W	YDL173W	PAR32	hom	Verified	1.43430061485854	0.0757432474667774	no	417	0.101831438651344	398	NA					Putative protein of unknown function; hyperphosphorylated upon rapamycin treatment in a Tap42p-dependent manner; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; PAR32 is not an essential gene	biological_process	molecular_function	cytoplasm
YCR064C_d	YCR064C	YCR064C	hom	Dubious	1.43123248745336	0.0761817977926295	no	418	0.109052504280462	457	NA	FF				Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene BUD31	Unknown	Unknown	Unknown
YDR058C	YDR058C	TGL2	hom	Verified	1.43078314792522	0.0762461871639473	no	419	0.079378599766873	356	NA	FT	PROTEIN LOCALIZATION|LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION		Triacylglycerol lipase that is localized to the mitochondria; has lipolytic activity towards triacylglycerols and diacylglycerols when expressed in E. coli	triglyceride catabolic process	triglyceride lipase activity	mitochondrion
YDR298C	YDR298C	ATP5	hom	Verified	1.43004442412678	0.0763521346748834	no	420	0.0893265983128756	370	NA	FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS	MITOCHONDRION		Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase, which is an evolutionarily conserved enzyme complex required for ATP synthesis; homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein); phosphorylated	ATP synthesis coupled proton transport	hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism	mitochondrion|integral to membrane|mitochondrial proton-transporting ATP synthase, stator stalk|mitochondrial proton-transporting ATP synthase complex
YPL164C	YPL164C	MLH3	hom	Verified	1.43002982952406	0.0763542289555934	no	421	0.0750076148374791	285	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Protein involved in DNA mismatch repair and crossing-over during meiotic recombination; forms a complex with Mlh1p; mammalian homolog is implicated mammalian microsatellite instability	mismatch repair|reciprocal meiotic recombination	molecular_function	nucleus|MutLbeta complex
YCL001W-A_p	YCL001W-A	YCL001W-A	hom	Uncharacterized	1.42919396531827	0.076474245856672	no	422	0.10082514006656	394	NA					Putative protein of unknown function; YCL001W-A gene has similarity to DOM34 and is present in a region duplicated between chromosomes XIV and III	biological_process	molecular_function	cellular_component
YGR155W	YGR155W	CYS4	hom	Verified	1.42108301825559	0.0776463131078099	no	423	0.0855080079369166	399	NA	FT	KETONE METABOLISM|CELL CYCLE|AMINO ACID METABOLISM	MITOCHONDRION		Cystathionine beta-synthase, catalyzes synthesis of cystathionine from serine and homocysteine, the first committed step in cysteine biosynthesis; responsible for hydrogen sulfide generation; advances passage through START by promoting cell growth which requires catalytic activity, and reducing critical cell size independent of catalytic activity; mutations in human ortholog cause homocystinuria	cysteine biosynthetic process from serine|hydrogen sulfide biosynthetic process|cysteine biosynthetic process via cystathionine|transsulfuration|traversing start control point of mitotic cell cycle	cystathionine beta-synthase activity	mitochondrion|cytoplasm
YKL169C_d	YKL169C	YKL169C	hom	Dubious	1.42031524458269	0.077757962493233	no	424	0.123692183629365	463	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene MRPL38	Unknown	Unknown	Unknown
YHR191C	YHR191C	CTF8	hom	Verified	1.41762821001478	0.0781496697879256	no	425	0.10851408917342	407	NA	FT	CELL CYCLE|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME		Subunit of a complex with Ctf18p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion	maintenance of DNA trinucleotide repeats|mitotic sister chromatid cohesion	molecular_function	Ctf18 RFC-like complex
YBR175W	YBR175W	SWD3	hom	Verified	1.41687272627846	0.0782600709103281	no	426	0.0765707474320287	331	NA	FT	CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS|CHROMOSOME		Essential subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member and ortholog of mammalian WDR5	histone H3-K4 methylation|telomere maintenance|chromatin silencing at telomere	histone methyltransferase activity (H3-K4 specific)	Set1C/COMPASS complex
YOR044W	YOR044W	IRC23	hom	Verified	1.41103787402329	0.0791167233766919	no	427	0.0721249890270545	327	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Putative protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; null mutant displays increased levels of spontaneous Rad52p foci; IRC23 has a paralog, BSC2, that arose from the whole genome duplication	biological_process	molecular_function	endoplasmic reticulum
YBR098W	YBR098W	MMS4	hom	Verified	1.40943328875307	0.079353543286705	no	428	0.0700298073534113	285	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION	NUCLEUS		Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in recombination, DNA repair, and joint molecule formation/resolution during meiotic recombination; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates the function of Mms4p-Mus81p	DNA repair|DNA topological change|regulation of reciprocal meiotic recombination|reciprocal meiotic recombination|resolution of meiotic recombination intermediates|response to DNA damage stimulus	transcription coactivator activity|endonuclease activity|crossover junction endodeoxyribonuclease activity	Holliday junction resolvase complex|nucleus
YOR343C_d	YOR343C	YOR343C	hom	Dubious	1.40935307431339	0.079365396161555	no	429	0.0605748417787281	301	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDL121C_p	YDL121C	YDL121C	hom	Uncharacterized	1.40900632703629	0.0794166486393389	no	430	0.0580646418966609	228	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDL121C is not an essential protein	biological_process	molecular_function	endoplasmic reticulum
YPL152W	YPL152W	RRD2	hom	Verified	1.40835437895133	0.0795130804612769	no	431	0.0735691054772518	387	NA	FT	CELL CYCLE|CYTOSKELETON ORGANIZATION			Peptidyl-prolyl cis/trans-isomerase; also activates the phosphotyrosyl phosphatase activity of protein phosphatase 2A (PP2A); regulates G1 phase progression, the osmoresponse, microtubule dynamics; subunit of the Tap42p-Pph21p-Rrd2p complex; protein abundance increases in response to DNA replication stress	mitotic spindle organization in nucleus|response to osmotic stress	peptidyl-prolyl cis-trans isomerase activity|protein phosphatase type 2A regulator activity	protein phosphatase type 2A complex
YHL008C_p	YHL008C	YHL008C	hom	Uncharacterized	1.40442134525804	0.0800967091811291	no	432	0.0822654250437577	317	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Putative protein of unknown function, may be involved in the uptake of chloride ions; does not appear to be involved in monocarboxylic acid transport; green fluorescent protein (GFP)-fusion protein localizes to the vacuole	chloride transport|monocarboxylic acid transport	monocarboxylic acid transmembrane transporter activity|transporter activity	integral to membrane|fungal-type vacuole
YMR067C	YMR067C	UBX4	hom	Verified	1.40194758826594	0.0804654491533842	no	433	0.103634214144528	411	NA	FT	PROTEOLYSIS	NUCLEUS		UBX domain-containing protein that interacts with Cdc48p; involved in degradation of polyubiquitinated proteins via the ERAD (ER-associated degradation) pathway; modulates the Cdc48p-Nplp-Ufd1p AAA ATPase complex during its role in delivery of misfolded proteins to the proteasome; protein abundance increases in response to DNA replication stress	ER-associated protein catabolic process|sporulation resulting in formation of a cellular spore	protein complex binding	nucleus|cytoplasm|extrinsic to membrane
YDR438W	YDR438W	THI74	hom	Verified	1.40184180042404	0.0804812465111678	no	434	0.0861766473606118	345	NA	FT		MITOCHONDRION		Mitochondrial transporter repressible by thiamine; THI74 has a paralog, YML018C, that arose from the whole genome duplication	biological_process	molecular_function	mitochondrion|integral to membrane
YNL292W	YNL292W	PUS4	hom	Verified	1.40113137413449	0.0805873955738079	no	435	0.0845536333551121	359	NA	FT	RNA PROCESSING	NUCLEUS|MITOCHONDRION		Pseudouridine synthase, catalyzes only the formation of pseudouridine-55 (Psi55), a highly conserved tRNA modification, in mitochondrial and cytoplasmic tRNAs; PUS4 overexpression leads to translational derepression of GCN4 (Gcd- phenotype)	tRNA modification	pseudouridine synthase activity	mitochondrion|nucleus
YHR142W	YHR142W	CHS7	hom	Verified	1.40062887017952	0.0806625415393307	no	436	0.197317809427487	677	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein of unknown function; may be involved in chitin biosynthesis by regulation of Chs3p export from the ER; relocalizes from bud neck to ER upon DNA replication stress	protein folding|ER to Golgi vesicle-mediated transport|fungal-type cell wall chitin biosynthetic process	unfolded protein binding	integral to membrane|endoplasmic reticulum membrane
YAL017W	YAL017W	PSK1	hom	Verified	1.3990602617425	0.0808974564391663	no	437	0.0701790625476509	234	NA	FT	SIGNALING|TRANSLATION|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION|GEN. OF PRECURSOR METABOLITES AND ENERGY			PAS domain-containing serine/threonine protein kinase; coordinately regulates protein synthesis and carbohydrate metabolism and storage in response to a unknown metabolite that reflects nutritional status; PSK1 has a paralog, PSK2, that arose from the whole genome duplication	regulation of (1->6)-beta-D-glucan biosynthetic process|negative regulation of glycogen biosynthetic process|protein phosphorylation	protein serine/threonine kinase activity|protein kinase activity	cytoplasm
YPR100W	YPR100W	MRPL51	hom	Verified	1.39609362152489	0.081343152175666	no	438	0.111141564655167	420	NA	FT	TRANSLATION|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation|aerobic respiration	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YPL069C	YPL069C	BTS1	hom	Verified	1.39599359869349	0.0813582114051881	no	439	0.207080632420673	740	NA	FF|FT	PROTEIN LOCALIZATION|LIPID METABOLISM	MITOCHONDRION		Geranylgeranyl diphosphate synthase, increases the intracellular pool of geranylgeranyl diphosphate, suppressor of bet2 mutation that causes defective geranylgeranylation of small GTP-binding proteins that mediate vesicular traffic	terpenoid biosynthetic process	farnesyltranstransferase activity	mitochondrion
YBR134W_d	YBR134W	YBR134W	hom	Dubious	1.395456165804	0.081439162192031	no	440	0.0730684872550547	369	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YKL027W	YKL027W	YKL027W	hom	Verified	1.39501126625389	0.0815062210988932	no	441	0.0845077721952505	332	NA	FT		MITOCHONDRION		Protein of unknown function, localized to the mitochondrial outer membrane	biological_process	molecular_function	mitochondrial outer membrane|mitochondrion
YER139C	YER139C	RTR1	hom	Verified	1.39409082049162	0.081645090408302	no	442	0.0781279023789574	362	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		CTD phosphatase; dephosphorylates S5-P in the C-terminal domain of Rpo21p; has a cysteine-rich motif required for function and conserved in eukaryotes; shuttles between the nucleus and cytoplasm; RTR1 has a paralog, RTR2, that arose from the whole genome duplication	dephosphorylation of RNA polymerase II C-terminal domain|transcription from RNA polymerase II promoter	CTD phosphatase activity	nucleus|cytoplasm
YGR287C	YGR287C	IMA1	hom	Verified	1.39217812872064	0.0819342320307409	no	443	0.0805228305868354	343	NA	FT	CARBOHYDRATE METABOLISM	MITOCHONDRION		Major isomaltase (alpha-1,6-glucosidase/alpha-methylglucosidase); required for isomaltose utilization; specificity for isomaltose, alpha-methylglucoside, and palatinose; member of the IMA isomaltase family	disaccharide catabolic process	oligo-1,6-glucosidase activity	mitochondrion|ribosome
YHR067W	YHR067W	HTD2	hom	Verified	1.39121823715721	0.0820796293182975	no	444	0.113276753618557	455	NA	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS	MITOCHONDRION		Mitochondrial 3-hydroxyacyl-thioester dehydratase involved in fatty acid biosynthesis, required for respiratory growth and for normal mitochondrial morphology	fatty acid biosynthetic process	3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity	mitochondrion
YNL090W	YNL090W	RHO2	hom	Verified	1.38987994608609	0.0822826680804424	no	445	0.0852154553987068	374	NA	FT	SIGNALING|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION	PLASMA MEMBRANE		Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, involved in the establishment of cell polarity and in microtubule assembly	microtubule-based process|fungal-type cell wall organization|actin filament organization|establishment of cell polarity|small GTPase mediated signal transduction	GTPase activity	membrane
YMR126C_p	YMR126C	DLT1	hom	Uncharacterized	1.38987203172994	0.0822838699306134	no	446	0.0632710927087466	281	NA					Protein of unknown function, mutant sensitive to 6-azauracil (6AU) and mycophenolic acid (MPA)	biological_process	molecular_function	cellular_component
YKL048C	YKL048C	ELM1	hom	Verified	1.38899839746329	0.0824166186771084	no	447	0.0833701955934553	372	NA	FT	CELL CYCLE|CELL DIVISION|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Serine/threonine protein kinase that regulates cellular morphogenesis, septin behavior, and cytokinesis; required for the regulation of other kinases, such as Kin4p; forms part of the bud neck ring	positive regulation of protein autophosphorylation|protein autophosphorylation|cell morphogenesis|budding cell bud growth|protein phosphorylation|response to drug|septin checkpoint|pseudohyphal growth|glucose metabolic process|axial cellular bud site selection|response to osmotic stress|cytokinesis	protein serine/threonine kinase activity|protein kinase activity	cellular bud neck contractile ring
YPL049C	YPL049C	DIG1	hom	Verified	1.38793560351281	0.0825783275643793	no	448	0.103269742749163	427	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		MAP kinase-responsive inhibitor of the Ste12p transcription factor, involved in the regulation of mating-specific genes and the invasive growth pathway; related regulators Dig1p and Dig2p bind to Ste12p	negative regulation of transcription from RNA polymerase II promoter by pheromones|Unknown	DNA binding|transcription factor binding	nucleus
YNL200C	YNL200C	YNL200C	hom	Verified	1.38382691959572	0.0832057290854805	no	449	0.0664239679562036	283	NA	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM	MITOCHONDRION		NADHX epimerase; catalyzes isomerization of (R)- and (S)-NADHX; homologous to AIBP in mammals and the N- terminal domain of YjeF in E.coli; enzyme is widespread in eukaryotes, prokaryotes and archaea; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	nicotinamide nucleotide metabolic process	NADHX epimerase activity	mitochondrion|cytoplasm
YMR293C	YMR293C	HER2	hom	Verified	1.3825112390288	0.0834073909856973	no	450	0.101058041577225	418	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION	MITOCHONDRION		Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; required for remodeling of ER caused by Hmg2p overexpression; similar to bacterial GatA glutamyl-tRNA amidotransferase	endoplasmic reticulum organization|glutaminyl-tRNAGln biosynthesis via transamidation	glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity	mitochondrion|glutamyl-tRNA(Gln) amidotransferase complex
YDR226W	YDR226W	ADK1	hom	Verified	1.38059374561872	0.0837019537370504	no	451	0.0956628979865603	429	NA	FT	NUCLEOTIDE METABOLISM	MITOCHONDRION		Adenylate kinase, required for purine metabolism; localized to the cytoplasm and the mitochondria; lacks cleavable signal sequence; protein abundance increases in response to DNA replication stress	ADP biosynthetic process|DNA replication initiation|nucleotide metabolic process	adenylate kinase activity	mitochondrion|mitochondrial intermembrane space|cytoplasm
YNL044W	YNL044W	YIP3	hom	Verified	1.38048787682063	0.0837182398955466	no	452	0.0761587909078825	307	NA	FT	VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Protein localized to COPII vesicles, proposed to be involved in ER to Golgi transport; interacts with members of the Rab GTPase family and Yip1p; also interacts with Rtn1p	ER to Golgi vesicle-mediated transport	molecular_function	Golgi apparatus|endoplasmic reticulum|ER to Golgi transport vesicle
YPL141C	YPL141C	FRK1	hom	Verified	1.37721690603752	0.0842225982344347	no	453	0.0820712895503622	361	NA	FT	PROTEIN PHOSPHORYLATION			Protein kinase of unknown cellular role; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; interacts with rRNA transcription and ribosome biogenesis factors and the long chain fatty acyl-CoA synthetase Faa3p; FRK1 has a paralog, KIN4, that arose from the whole genome duplication	protein phosphorylation	protein kinase activity	cytoplasm
YJR053W	YJR053W	BFA1	hom	Verified	1.37657748619823	0.0843214577494237	no	454	0.0601311413472059	266	NA	FT	CELL CYCLE|CELL DIVISION	CYTOSKELETON		Component of the GTPase-activating Bfa1p-Bub2p complex involved in multiple cell cycle checkpoint pathways that control exit from mitosis	regulation of exit from mitosis|mitotic cell cycle spindle orientation checkpoint	GTPase activator activity	spindle pole body
YIL121W	YIL121W	QDR2	hom	Verified	1.37642458594637	0.0843451102697429	no	455	0.069830717310665	264	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; exports copper; has broad substrate specificity and can transport many mono- and divalent cations; transports a variety of drugs and is required for resistance to quinidine, barban, cisplatin, and bleomycin; contributes to potassium homeostasis; expression is regulated by copper	drug transmembrane transport|potassium ion import	drug transmembrane transporter activity	integral to membrane|integral to plasma membrane
YDR455C_d	YDR455C	YDR455C	hom	Dubious	1.37588908417297	0.0844279876245199	no	456	0.125517993459302	538	NA	FF				Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YDR456W	Unknown	Unknown	Unknown
YDR065W	YDR065W	RRG1	hom	Verified	1.37573147982768	0.0844523910192371	no	457	0.0833084197217673	375	NA	FT	ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS	MITOCHONDRION		Protein of unknown function, required for vacuolar acidification and mitochondrial genome maintenance; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	mitochondrial genome maintenance|vacuolar acidification	molecular_function	mitochondrion
YDR360W_d	YDR360W	OPI7	hom	Dubious	1.37224235825396	0.0849940015557045	no	458	0.0870936572907396	355	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene VID21/YDR359C.	Unknown	Unknown	Unknown
YNL146W_p	YNL146W	YNL146W	hom	Uncharacterized	1.36965160090282	0.0853978418254527	no	459	0.0848534854942676	310	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YNL146W is not an essential gene	biological_process	molecular_function	endoplasmic reticulum
YLR039C	YLR039C	RIC1	hom	Verified	1.36921170790355	0.0854665536607651	no	460	0.185719773929803	598	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|NUCLEUS|GOLGI APPARATUS		Protein involved in retrograde transport to the cis-Golgi network; forms heterodimer with Rgp1p that acts as a GTP exchange factor for Ypt6p; involved in transcription of rRNA and ribosomal protein genes	intracellular protein transport|retrograde transport, endosome to Golgi	guanyl-nucleotide exchange factor activity	nucleus|Ric1p-Rgp1p complex|Golgi membrane|guanyl-nucleotide exchange factor complex
YOR276W	YOR276W	CAF20	hom	Verified	1.36900730601089	0.0854984955779366	no	461	0.0789364183984768	307	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION			Phosphoprotein of the mRNA cap-binding complex involved in translational control, repressor of cap-dependent translation initiation, competes with eIF4G for binding to eIF4E	negative regulation of translation|positive regulation of cytoplasmic mRNA processing body assembly	translation regulator activity	mRNA cap binding complex
YDR029W_d	YDR029W	YDR029W	hom	Dubious	1.36868655957084	0.0855486366970595	no	462	0.0658154715586922	260	NA					Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YCR071C	YCR071C	IMG2	hom	Verified	1.36687832746015	0.0858317230801189	no	463	0.0996415955407031	394	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YLR201C	YLR201C	COQ9	hom	Verified	1.36676035640573	0.085850216282087	no	464	0.0792082970966825	331	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes	ubiquinone biosynthetic process|aerobic respiration	molecular_function	mitochondrion|mitochondrial inner membrane
YKR010C	YKR010C	TOF2	hom	Verified	1.36602132389051	0.0859661352554376	no	465	0.0693508715399614	285	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|CHROMOSOME SEGREGATION|GENE SILENCING	NUCLEUS|MITOCHONDRION		Protein required for rDNA silencing and mitotic rDNA condensation; stimulates Cdc14p phosphatase activity and biphasic release to promote rDNA repeat segregation; required for condensin recruitment to the replication fork barrier site; TOF2 has a paralog, NET1, that arose from the whole genome duplication	nucleolus organization|rDNA condensation|chromatin silencing at rDNA|protein localization to nucleolar rDNA repeats	phosphatase activator activity	mitochondrion|nucleolus
YNL239W	YNL239W	LAP3	hom	Verified	1.36401698462646	0.0862811100778775	no	466	0.0765020627305878	332	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM|PROTEOLYSIS	MITOCHONDRION		Cysteine aminopeptidase with homocysteine-thiolactonase activity; protects cells against homocysteine toxicity; has bleomycin hydrolase activity in vitro; transcription is regulated by galactose via Gal4p; orthologous to human BLMH	response to antibiotic|negative regulation of transcription from RNA polymerase II promoter|homocysteine catabolic process	double-stranded DNA binding|cysteine-type peptidase activity|mRNA binding|single-stranded DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding	mitochondrion|cytoplasm
YOR076C	YOR076C	SKI7	hom	Verified	1.362855177777	0.086464078620977	no	467	0.093118799717939	362	NA	FT	TRANSLATION|NUCLEOTIDE METABOLISM			Coupling protein that mediates interactions between the Ski complex and the cytoplasmic exosome during 3'-5' RNA degradation; eRF3-like domain targets nonstop mRNA for degradation; null mutants have superkiller phenotype	nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'|nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay|nuclear-transcribed mRNA catabolic process, non-stop decay|nonfunctional rRNA decay	protein binding, bridging	Ski complex|cytoplasmic exosome (RNase complex)|cytoplasm
YML047W-A_d	YML047W-A	YML047W-A	hom	Dubious	1.35988048057322	0.0869338744203226	no	468	0.0811937509339944	320	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YML122C_d	YML122C	YML122C	hom	Dubious	1.35713698521582	0.0873688443091373	no	469	0.193520941999054	658	NA	FF				Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YGL185C_p	YGL185C	YGL185C	hom	Uncharacterized	1.35646837667766	0.0874750952293994	no	470	0.112638582133009	414	NA	FT	OXIDATION-REDUCTION PROCESS			Putative protein with sequence similarity to hydroxyacid dehydrogenases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	metabolic process	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	cytoplasm
YEL038W	YEL038W	UTR4	hom	Verified	1.3559236658081	0.0875617284015513	no	471	0.0548175578796767	242	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Protein with sequence similarity to 2,3-diketo-5-methylthiopentyl-1-phosphate enolase-phosphatases, involved in methionine salvage; found in both the cytoplasm and nucleus	L-methionine salvage from methylthioadenosine	acireductone synthase activity	nucleus|cytoplasm
YLR436C	YLR436C	ECM30	hom	Verified	1.35481453965235	0.0877383265042414	no	472	0.105033383580386	403	NA	FT	CELL WALL ORG/BIOGENESIS			Putative protein of unknown function; may play a role in cell wall biosynthesis, mutants have abormal relative levels of mannose and glucose and have Gap1p sorting and transport defects; (GFP)-fusion protein localizes to the cytoplasm	fungal-type cell wall organization	molecular_function	cytoplasm
YNL093W	YNL093W	YPT53	hom	Verified	1.35175155672425	0.0882274029562173	no	473	0.119444935119638	470	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING|VACUOLAR TRANSPORT	PLASMA MEMBRANE		Rab family GTPase; similar to Ypt51p and Ypt52p and to mammalian rab5; required for vacuolar protein sorting and endocytosis; YPT53 has a paralog, VPS21, that arose from the whole genome duplication	endocytosis|protein targeting to vacuole	GTPase activity	late endosome
YGL136C	YGL136C	MRM2	hom	Verified	1.35163862677074	0.0882454736121369	no	474	0.0610168447956676	249	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	MITOCHONDRION		Mitochondrial 2' O-ribose methyltransferase, required for methylation of U(2791) in 21S rRNA; MRM2 deletion confers thermosensitive respiration and loss of mitochondrial DNA; has similarity to Spb1p and Trm7p, and to E. coli FtsJ/RrmJ	rRNA methylation	rRNA (uridine-2'-O-)-methyltransferase activity	mitochondrion
YER096W	YER096W	SHC1	hom	Verified	1.34693627112169	0.0890003792639431	no	475	0.0947556731639299	388	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM			Sporulation-specific activator of Chs3p (chitin synthase III); required for the synthesis of the chitosan layer of ascospores; transcriptionally induced at alkaline pH; SHC1 has a paralog, SKT5, that arose from the whole genome duplication	ascospore formation|chitin biosynthetic process	enzyme activator activity	prospore membrane
YLL028W	YLL028W	TPO1	hom	Verified	1.34658837230214	0.0890564205564047	no	476	0.0529079542357996	220	NA	FT		PLASMA MEMBRANE		Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; recognizes spermine, putrescine, and spermidine; catalyzes uptake of polyamines at alkaline pH and excretion at acidic pH; phosphorylation enhances activity and sorting to the plasma membrane	spermidine transport|putrescine transport|spermine transport	spermidine transmembrane transporter activity|spermine transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane|cellular bud membrane|plasma membrane
YLR102C	YLR102C	APC9	hom	Verified	1.34576625292684	0.089188956041433	no	477	0.0776598791096615	322	NA	FT	CELL CYCLE|CHROMATIN ORGANIZATION|CELL DIVISION	NUCLEUS	UBIQUITIN LIGASE COMPLEX	Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition	chromatin assembly|protein ubiquitination	ubiquitin-protein ligase activity	anaphase-promoting complex
YHR015W	YHR015W	MIP6	hom	Verified	1.34450888630268	0.0893919424068952	no	478	0.0753247217425514	310	NA	FT	RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	Putative RNA-binding protein; interacts with Mex67p, which is a component of the nuclear pore involved in nuclear mRNA export; MIP6 has a paralog, PES4, that arose from the whole genome duplication	mRNA export from nucleus	RNA binding	nuclear pore
YAR028W_p	YAR028W	YAR028W	hom	Uncharacterized	1.34354108608666	0.0895484157390784	no	479	0.104539295435624	391	NA					Putative integral membrane protein, member of DUP240 gene family; GFP-fusion protein is induced in response to the DNA-damaging agent MMS	biological_process	molecular_function	cellular_component
YOL043C	YOL043C	NTG2	hom	Verified	1.33948501389211	0.0902064149472013	no	480	0.0643027654015117	243	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair, localizes to the nucleus; sumoylated; NTG2 has a paralog, NTG1, that arose from the whole genome duplication	base-excision repair|base-excision repair, AP site formation	oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity|DNA-(apurinic or apyrimidinic site) lyase activity	nucleus
YOR034C-A_p	YOR034C-A	YOR034C-A	hom	Uncharacterized	1.33871268080735	0.0903321132406274	no	481	0.117002629969121	426	NA					Putative protein of unknown function; identified by expression profiling and mass spectrometry	biological_process	molecular_function	cellular_component
YIL054W_p	YIL054W	YIL054W	hom	Uncharacterized	1.33854027155452	0.090360190839742	no	482	0.0928825439971093	377	NA					Protein of unknown function; expressed at both mRNA and protein levels	biological_process	molecular_function	cellular_component
YNL205C_d	YNL205C	YNL205C	hom	Dubious	1.33387381799902	0.0911226067329461	no	483	0.0946360189337843	383	NA					Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YCR003W	YCR003W	MRPL32	hom	Verified	1.32997015673485	0.0917640521188568	no	484	0.126309712333323	480	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial inner membrane|mitochondrial large ribosomal subunit
YEL004W	YEL004W	YEA4	hom	Verified	1.32960704195666	0.091823888364345	no	485	0.0610328999287146	185	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter required for cell wall chitin synthesis; localized to the ER	fungal-type cell wall chitin biosynthetic process|UDP-N-acetylglucosamine transport|UDP-glucose transport|transmembrane transport	UDP-N-acetylglucosamine transmembrane transporter activity	integral to membrane|endoplasmic reticulum
YBR266C_d	YBR266C	SLM6	hom	Dubious	1.3291247137882	0.0919034139963944	no	486	0.0981480440414141	368	NA					Protein with a potential role in actin cytoskeleton organization; gene exhibits synthetic genetic interaction with MSS4 encoding phosphatidylinositol 4-phosphate kinase	Unknown	Unknown	Unknown
YPR002W	YPR002W	PDH1	hom	Verified	1.32721190845326	0.0922192971117853	no	487	0.104599968439058	414	NA	FT	KETONE METABOLISM	MITOCHONDRION		Mitochondrial protein that participates in respiration, induced by diauxic shift; homologous to E. coli PrpD, may take part in the conversion of 2-methylcitrate to 2-methylisocitrate	propionate metabolic process|propionate catabolic process, 2-methylcitrate cycle	2-methylcitrate dehydratase activity	mitochondrial outer membrane|mitochondrion|cytoplasm
YPL109C_p	YPL109C	YPL109C	hom	Uncharacterized	1.32668324775198	0.0923067424041539	no	488	0.0823743506665147	320	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YHR076W	YHR076W	PTC7	hom	Verified	1.32419686277768	0.0927188362516876	no	489	0.110155850438187	429	NA	FT		ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION		Type 2C protein phosphatase (PP2C); alternatively spliced to create two mRNA isoforms; protein from spliced form localizes to the mitochondria while the one from the unspliced form is localized to the nuclear envelope	biological_process	protein serine/threonine phosphatase activity	nuclear envelope|mitochondrion
YER015W	YER015W	FAA2	hom	Verified	1.32370517268592	0.0928004899365955	no	490	0.0940779415271562	404	NA	FT	KETONE METABOLISM|LIPID METABOLISM	MITOCHONDRION		Medium chain fatty acyl-CoA synthetase, activates imported fatty acids; accepts a wide range of fatty acid chain lengths with a preference for medium chains, C9:0-C13:0; localized to the peroxisome	long-chain fatty acid metabolic process	long-chain fatty acid-CoA ligase activity|very long-chain fatty acid-CoA ligase activity|medium-chain fatty acid-CoA ligase activity	mitochondrion|peroxisome
YOR142W	YOR142W	LSC1	hom	Verified	1.32329872746767	0.0928680273638132	no	491	0.0774651165637288	343	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Alpha subunit of succinyl-CoA ligase, which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate; phosphorylated	tricarboxylic acid cycle|succinyl-CoA metabolic process	succinate-CoA ligase (ADP-forming) activity	mitochondrial nucleoid|mitochondrion
YPL197C_d	YPL197C	YPL197C	hom	Dubious	1.32150141334561	0.0931671157900427	no	492	0.105464492200468	371	NA					Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the ribosomal gene RPB7B	Unknown	Unknown	Unknown
YGR282C	YGR282C	BGL2	hom	Verified	1.32134160956615	0.0931937429233859	no	493	0.09261178870668	434	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM			Endo-beta-1,3-glucanase, major protein of the cell wall, involved in cell wall maintenance	fungal-type cell wall organization	1,3-beta-glucanosyltransferase activity|glucan endo-1,3-beta-D-glucosidase activity	fungal-type cell wall
YER158C_p	YER158C	YER158C	hom	Uncharacterized	1.31663417866208	0.0939806382212318	no	494	0.0611982880086132	307	NA					Protein of unknown function; potentially phosphorylated by Cdc28p; YER158C has a paralog, AFR1, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YHR004C	YHR004C	NEM1	hom	Verified	1.31556001092865	0.0941608814410069	no	495	0.103028381978819	416	NA	FF|FT	LIPID METABOLISM|MEMBRANE ORGANIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|MITOCHONDRION		Probable catalytic subunit of Nem1p-Spo7p phosphatase holoenzyme; regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology and sporulation; homolog of the human protein Dullard	negative regulation of phospholipid biosynthetic process|nuclear envelope organization	phosphoprotein phosphatase activity	Nem1-Spo7 phosphatase complex|mitochondrion|integral to membrane
YNL076W	YNL076W	MKS1	hom	Verified	1.31549202501448	0.0941722979179083	no	496	0.0822315361971804	315	NA	FT	TRANSCRIPTION FROM RNA POL II|SIGNALING	NUCLEUS		Pleiotropic negative transcriptional regulator involved in Ras-CAMP and lysine biosynthetic pathways and nitrogen regulation; involved in retrograde (RTG) mitochondria-to-nucleus signaling	regulation of nitrogen utilization|negative regulation of transcription from RNA polymerase II promoter|Unknown|mitochondria-nucleus signaling pathway	molecular_function	cytoplasm
YGR059W	YGR059W	SPR3	hom	Verified	1.31525096919525	0.094212785240496	no	497	0.0909818716886087	356	NA	FT	CELL CYCLE	SITE OF POLARIZED GROWTH|CYTOSKELETON		Sporulation-specific homolog of the yeast CDC3/10/11/12 family of bud neck microfilament genes; septin protein involved in sporulation; regulated by ABFI	ascospore formation	structural molecule activity	septin complex|ascospore wall|prospore membrane
YLR342W-A_p	YLR342W-A	YLR342W-A	hom	Uncharacterized	1.31467347601928	0.0943098322290516	no	498	0.0983034552184382	385	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YMR166C_p	YMR166C	YMR166C	hom	Uncharacterized	1.31421887927655	0.0943862784762119	no	499	0.103718258246142	434	NA	FT		MITOCHONDRION		Predicted transporter of the mitochondrial inner membrane; has similarity to human mitochondrial ATP-Mg/Pi carriers; YMR166C is not an essential gene	transport	transporter activity	integral to membrane|mitochondrial inner membrane
YHR150W	YHR150W	PEX28	hom	Verified	1.31337849965225	0.0945277193410478	no	500	0.084454623638274	382	NA	FT	PEROXISOME ORGANIZATION			Peroxisomal integral membrane peroxin, involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p	peroxisome organization	molecular_function	integral to membrane|peroxisomal membrane
YOR052C	YOR052C	YOR052C	hom	Verified	1.31327971618159	0.0945443554418972	no	501	0.09162688923346	369	NA	FT		NUCLEUS		Nuclear protein of unknown function; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner and by weak acid; transcriptionally regulated by Rpn4p along with proteasome subunit genes; putative ortholog of human AIRAP, which stimulates proteasome activity in response to arsenic; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	nucleus
YLR016C	YLR016C	PML1	hom	Verified	1.31311856736954	0.0945714991075844	no	502	0.057280533842574	263	NA	FT	RNA PROCESSING|RNA LOCALIZATION	NUCLEUS		Subunit of the RES complex, which is required for nuclear retention of unspliced pre-mRNAs; acts in the same pathway as Pml39p and Mlp1p	mRNA export from nucleus|mRNA splicing, via spliceosome|maintenance of RNA location	molecular_function	RES complex|nucleus|cytoplasm
YMR153C-A_d	YMR153C-A	YMR153C-A	hom	Dubious	1.31201126316073	0.094758167151844	no	503	0.0576445237065889	294	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NUP53	Unknown	Unknown	Unknown
YPR021C	YPR021C	AGC1	hom	Verified	1.30893185055183	0.0952787182455327	no	504	0.101163071090838	421	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Mitochondrial amino acid transporter, acts both as a glutamate uniporter and as an aspartate-glutamate exchanger; involved in nitrogen metabolism and nitrogen compound biosynthesis	L-glutamate transport|aspartate transport|cellular nitrogen compound biosynthetic process	antiporter activity|L-aspartate transmembrane transporter activity|L-glutamate transmembrane transporter activity|uniporter activity	mitochondrion|integral to membrane|mitochondrial inner membrane
YML104C	YML104C	MDM1	hom	Verified	1.3063473471691	0.0957172313331125	no	505	0.0582711677964309	233	NA	FT	MITOCHONDRION ORGANIZATION	CYTOSKELETON		Intermediate filament protein, required for nuclear and mitochondrial transmission to daughter buds; contains a Phox homology (PX) domain and specifically binds phosphatidylinositol 3-phosphate (PtdIns-3-P)	nuclear migration|mitochondrion inheritance|mitochondrion organization	structural constituent of cytoskeleton|phosphatidylinositol-3-phosphate binding	intermediate filament|integral to membrane|cytoplasm
YNR029C_p	YNR029C	YNR029C	hom	Uncharacterized	1.30418558538592	0.0960851567103695	no	506	0.0808376664569812	385	NA					Putative protein of unknown function, deletion confers reduced fitness in saline	biological_process	molecular_function	cytoplasm
YJL084C	YJL084C	ALY2	hom	Verified	1.30173183750037	0.0965040360154934	no	507	0.0798597778426392	352	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION			Alpha arrestin that controls nutrient-mediated intracellular sorting of permease Gap1p; interacts with AP-1 subunit Apl4p; phosphorylated by Npr1p and also by cyclin-CDK complex Pcl7p-Pho85p; promotes endocytosis of plasma membrane proteins; ALY2 has a paralog, ALY1, that arose from the whole genome duplication	Unknown|regulation of intracellular transport|ubiquitin-dependent endocytosis	protein binding, bridging|ubiquitin protein ligase binding	late endosome|cytoplasm|early endosome
YGL256W	YGL256W	ADH4	hom	Verified	1.29674311140238	0.0973597952238426	no	508	0.0811102940259043	372	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Alcohol dehydrogenase isoenzyme type IV, dimeric enzyme demonstrated to be zinc-dependent despite sequence similarity to iron-activated alcohol dehydrogenases; transcription is induced in response to zinc deficiency	fermentation|amino acid catabolic process to alcohol via Ehrlich pathway	alcohol dehydrogenase (NAD) activity	mitochondrion
YPL232W	YPL232W	SSO1	hom	Verified	1.29479361252695	0.0976957180273023	no	509	0.103515434189489	450	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION	PLASMA MEMBRANE		Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane and in vesicle fusion during sporulation; forms a complex with Sec9p that binds v-SNARE Snc2p; syntaxin homolog; functionally redundant with Sso2p	ascospore formation|ascospore-type prospore assembly|vesicle fusion	phosphatidic acid binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|SNAP receptor activity	SNARE complex|fungal-type vacuole membrane|plasma membrane|prospore membrane
YDR293C	YDR293C	SSD1	hom	Verified	1.29467797583424	0.0977156703267191	no	510	0.232580763932902	839	NA	FF|FT	CELL CYCLE|TRANSLATION|CELL WALL ORG/BIOGENESIS|CELL DIVISION|RNA LOCALIZATION	NUCLEUS|SITE OF POLARIZED GROWTH		Translational repressor with a role in polar growth and wall integrity; regulated by Cbk1p phosphorylation to effect bud-specific translational control and localization of specific mRNAs; interacts with TOR pathway components; contains a functional N-terminal nuclear localization sequence and nucleocytoplasmic shuttling appears to be critical to Ssd1p function	regulation of fungal-type cell wall organization|negative regulation of translation|intracellular mRNA localization	mRNA binding|mRNA 5'-UTR binding|translation repressor activity, nucleic acid binding	nucleus|cellular bud|cytoplasmic stress granule|cytoplasmic mRNA processing body|cellular bud neck|cytoplasm
YLR119W	YLR119W	SRN2	hom	Verified	1.2928685234168	0.0980282678499051	no	511	0.10591695237405	432	NA	FT	PROTEIN LOCALIZATION|PROTEOLYSIS|VACUOLAR TRANSPORT			Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; suppressor of rna1-1 mutation; may be involved in RNA export from nucleus	protein targeting to membrane|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|protein targeting to vacuole	protein binding	endosome|ESCRT I complex
YPR076W_d	YPR076W	YPR076W	hom	Dubious	1.29201089689063	0.0981766854623138	no	512	0.11167278325638	423	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YOR205C	YOR205C	GEP3	hom	Verified	1.29192441599318	0.0981916606519152	no	513	0.0972163276022971	418	NA	FT		MITOCHONDRION		Protein required for mitochondrial ribosome small subunit biogenesis; null mutant is defective in respiration and in maturation of 15S rRNA; protein is localized to the mitochondrial inner membrane; null mutant interacts synthetically with prohibitin (phb1)	maturation of SSU-rRNA	molecular_function	mitochondrion|mitochondrial inner membrane
YNL284C	YNL284C	MRPL10	hom	Verified	1.29102992998487	0.0983466496455828	no	514	0.10773403532369	422	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL10 and YmL18) on two-dimensional SDS gels	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YDR129C	YDR129C	SAC6	hom	Verified	1.28700868591797	0.0990456303431636	no	515	0.229814837986112	824	NA	FF|FT	VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CELL DIVISION|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Fimbrin, actin-bundling protein; cooperates with Scp1p (calponin/transgelin) in the organization and maintenance of the actin cytoskeleton; relocalizes from plasma membrane to cytoplasm upon DNA replication stress	bipolar cellular bud site selection|actin filament organization|endocytosis|response to osmotic stress	actin filament binding|protein binding, bridging	actin filament bundle|mating projection tip|actin cortical patch
YNL146C-A_p	YNL146C-A	YNL146C-A	hom	Uncharacterized	1.28614883351728	0.0991955620318963	no	516	0.0898302899316354	339	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YBR056W	YBR056W	YBR056W	hom	Verified	1.28421346411846	0.0995336377089038	no	517	0.0897043872334482	394	NA	FT	CARBOHYDRATE METABOLISM			Putative glycoside hydrolase of the mitochondrial intermembrane space	biological_process	molecular_function	cytoplasm
YER074W	YER074W	RPS24A	hom	Verified	1.28343030029989	0.0996706819859824	no	518	0.098645026081916	402	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION	NUCLEUS|MITOCHONDRION	RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S24, no bacterial homolog; RPS24A has a paralog, RPS24B, that arose from the whole genome duplication	cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome	cytosolic small ribosomal subunit|mitochondrion
YHR011W	YHR011W	DIA4	hom	Verified	1.28188228697282	0.099941971240294	no	519	0.117863715386599	492	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Probable mitochondrial seryl-tRNA synthetase, mutant displays increased invasive and pseudohyphal growth	pseudohyphal growth|invasive growth in response to glucose limitation|mitochondrial seryl-tRNA aminoacylation	serine-tRNA ligase activity	mitochondrion|cytoplasm
YJR062C	YJR062C	NTA1	hom	Verified	1.28130219996174	0.100043770236941	no	520	0.0824102982577057	365	NA	FT	PROTEOLYSIS	MITOCHONDRION		Amidase, removes the amide group from N-terminal asparagine and glutamine residues to generate proteins with N-terminal aspartate and glutamate residues that are targets of ubiquitin-mediated degradation	cellular protein modification process|protein catabolic process	protein-N-terminal asparagine amidohydrolase activity	mitochondrion
YIL018W	YIL018W	RPL2B	hom	Verified	1.27921231248421	0.100411150616197	no	521	0.0891846290187048	351	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L2B; homologous to mammalian ribosomal protein L2 and bacterial L2; RPL2B has a paralog, RPL2A, that arose from the whole genome duplication; expression is upregulated at low temperatures	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YOR327C	YOR327C	SNC2	hom	Verified	1.27678816970526	0.100838521647373	no	522	0.113864052184818	445	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Vesicle membrane receptor protein (v-SNARE); involved in the fusion between Golgi-derived secretory vesicles with the plasma membrane; member of the synaptobrevin/VAMP family of R-type v-SNARE proteins; SNC2 has a paralog, SNC1, that arose from the whole genome duplication	endocytosis|exocytosis|Golgi to plasma membrane transport|vesicle fusion	SNAP receptor activity	SNARE complex|trans-Golgi network|endosome|transport vesicle membrane
YMR155W_p	YMR155W	YMR155W	hom	Uncharacterized	1.27666822080787	0.100859702758964	no	523	0.0968234684267362	368	NA					Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen	biological_process	molecular_function	integral to membrane
YKL206C	YKL206C	ADD66	hom	Verified	1.27635275326436	0.100915424910479	no	524	0.0948496079633567	363	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS			Protein involved in 20S proteasome assembly; forms a heterodimer with Pba1p that binds to proteasome precursors; similar to human PAC2 constituent of the PAC1-PAC2 complex involved in proteasome assembly	proteasome assembly	molecular_function	cytosol|cytoplasm
YLL024C	YLL024C	SSA2	hom	Verified	1.27551589139378	0.101063351526837	no	525	0.0855428439724076	352	NA	FT	PROTEIN LOCALIZATION	MITOCHONDRION		ATP binding protein involved in protein folding and vacuolar import of proteins; member of heat shock protein 70 (HSP70) family; associated with the chaperonin-containing T-complex; present in the cytoplasm, vacuolar membrane and cell wall; 98% identical with paralog Ssa1p, but subtle differences between the two proteins provide functional specificity with respect to propagation of yeast [URE3] prions and vacuolar-mediated degradations of gluconeogenesis enzymes	protein folding|SRP-dependent cotranslational protein targeting to membrane, translocation|response to stress	unfolded protein binding|ATPase activity|ATP binding	cytosol|fungal-type vacuole membrane|mitochondrion|fungal-type cell wall|plasma membrane|polysome|chaperonin-containing T-complex|cytoplasm
YKL096W	YKL096W	CWP1	hom	Verified	1.27528893663137	0.101103496070099	no	526	0.0822955934976444	333	NA	FT	MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS			Cell wall mannoprotein that localizes specifically to birth scars of daughter cells, linked to a beta-1,3- and beta-1,6-glucan heteropolymer through a phosphodiester bond; required for propionic acid resistance	fungal-type cell wall organization|ascospore-type prospore membrane assembly	structural constituent of cell wall	fungal-type cell wall|cellular birth scar|prospore membrane
YBL061C	YBL061C	SKT5	hom	Verified	1.2751163753903	0.10113402707602	no	527	0.112560693091225	487	NA	FT	CELL WALL ORG/BIOGENESIS|CELL DIVISION|CARBOHYDRATE METABOLISM	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON		Activator of Chs3p (chitin synthase III) during vegetative growth; recruits Chs3p to the bud neck via interaction with Bni4p; SKT5 has a paralog, SHC1, that arose from the whole genome duplication	fungal-type cell wall chitin biosynthetic process|response to osmotic stress|cytokinesis	enzyme activator activity	incipient cellular bud site|cellular bud neck septin ring|cellular bud neck
YDR409W	YDR409W	SIZ1	hom	Verified	1.27471737918606	0.101204646614316	no	528	0.102257332705507	380	NA	FT	CHROMOSOME SEGREGATION	NUCLEUS|SITE OF POLARIZED GROWTH|CHROMOSOME|CYTOSKELETON		SUMO/Smt3 ligase that promotes the attachment of sumo (Smt3p; small ubiquitin-related modifier) to proteins; binds Ubc9p and may bind septins; specifically required for sumoylation of septins in vivo; localized to the septin ring	protein sumoylation|chromosome segregation	SUMO ligase activity	nuclear chromatin|septin ring
YMR182C	YMR182C	RGM1	hom	Verified	1.2740313678798	0.101326149810209	no	529	0.0971649409950483	351	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS|CHROMOSOME		Putative zinc finger DNA binding transcription factor; contains two N-terminal C2H2 zinc fingers and C-terminal proline rich domain; overproduction impairs cell growth and induces expression of genes involved in monosaccharide catabolism and aldehyde metabolism; regulates expression of of Y-prime telomeric elements and subtelomeric COS genes; RGM1 has a paralog, USV1, that arose from the whole genome duplication	positive regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity	nuclear chromatin
YLR023C	YLR023C	IZH3	hom	Verified	1.27367755516023	0.101388857031171	no	530	0.0620041160902786	234	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family, expression induced by zinc deficiency; deletion reduces sensitivity to elevated zinc and shortens lag phase, overexpression reduces Zap1p activity	cellular zinc ion homeostasis	metal ion binding	integral to membrane|endoplasmic reticulum|membrane
YBR263W	YBR263W	SHM1	hom	Verified	1.27219203573673	0.101652448331115	no	531	0.0699859551916137	264	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		Mitochondrial serine hydroxymethyltransferase, converts serine to glycine plus 5,10 methylenetetrahydrofolate; involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis; reverse reaction generates serine	serine family amino acid biosynthetic process|one-carbon metabolic process	glycine hydroxymethyltransferase activity	mitochondrion
YDL219W	YDL219W	DTD1	hom	Verified	1.27208947035643	0.101670665980508	no	532	0.0864408567320681	333	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION			D-Tyr-tRNA(Tyr) deacylase, functions in protein translation, may affect nonsense suppression via alteration of the protein synthesis machinery; ubiquitous among eukaryotes	Unknown	D-leucyl-tRNA(Leu) deacylase activity|D-tyrosyl-tRNA(Tyr) deacylase activity	cytoplasm
YJR083C	YJR083C	ACF4	hom	Verified	1.26990773560249	0.102058748680994	no	533	0.0883553955583175	333	NA					Protein of unknown function, computational analysis of large-scale protein-protein interaction data suggests a possible role in actin cytoskeleton organization; potential Cdc28p substrate	biological_process	molecular_function	cellular_component
YGR169C	YGR169C	PUS6	hom	Verified	1.26690096087915	0.102595352558268	no	534	0.06328320703394	278	NA	FT	RNA PROCESSING	MITOCHONDRION		tRNA:pseudouridine synthase, catalyzes the conversion of uridine to pseudouridine at position 31 in cytoplasmic and mitochondrial tRNAs; mutation of Asp168 to Ala abolishes enzyme activity; not essential for viability	tRNA pseudouridine synthesis	pseudouridine synthase activity	mitochondrion|cytoplasm
YIR021W-A_p	YIR021W-A	YIR021W-A	hom	Uncharacterized	1.26648159636544	0.10267035709312	no	535	0.104852601596159	382	NA					Putative protein of unknown function; identified by expression profiling and mass spectrometry	biological_process	molecular_function	cellular_component
YKR024C	YKR024C	DBP7	hom	Verified	1.26559560267779	0.102828950612159	no	536	0.102318837964272	426	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Putative ATP-dependent RNA helicase of the DEAD-box family involved in ribosomal biogenesis; essential for growth under anaerobic conditions	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	ATP-dependent RNA helicase activity	nucleolus
YGR284C	YGR284C	ERV29	hom	Verified	1.26300323776417	0.103294008065964	no	537	0.109177184457229	424	NA	FT	VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein localized to COPII-coated vesicles; involved in vesicle formation and incorporation of specific secretory cargo; protein abundance increases in response to DNA replication stress	ER to Golgi vesicle-mediated transport	molecular_function	integral to membrane|ER to Golgi transport vesicle
YGL095C	YGL095C	VPS45	hom	Verified	1.262993306199	0.103295792671201	no	538	0.203227226642871	732	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Protein of the Sec1p/Munc-18 family, essential for vacuolar protein sorting; required for the function of Pep12p and the early endosome/late Golgi SNARE Tlg2p; essential for fusion of Golgi-derived vesicles with the prevacuolar compartment	vacuole inheritance|CVT pathway|positive regulation of SNARE complex assembly|Golgi vesicle fusion to target membrane|Golgi to vacuole transport|vacuole organization|vacuolar acidification|protein targeting to vacuole|Golgi to endosome transport	unfolded protein binding|SNARE binding	cytosol|SNARE complex|Golgi membrane|extrinsic to membrane
YPL192C	YPL192C	PRM3	hom	Verified	1.26206831358809	0.103462102953529	no	539	0.0841164616155021	354	NA	FT	MEMBRANE ORGANIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS|CYTOSKELETON		Pheromone-regulated protein required for nuclear envelope fusion during karyogamy; localizes to the outer face of the nuclear membrane; interacts with Kar5p at the spindle pole body	karyogamy involved in conjugation with cellular fusion|nuclear membrane fusion involved in karyogamy	molecular_function	nuclear envelope|spindle pole body|extrinsic to nuclear outer membrane
YBR244W	YBR244W	GPX2	hom	Verified	1.26150348366769	0.103563752828255	no	540	0.0803637749387257	361	NA	FT	OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS	NUCLEUS|MITOCHONDRION		Phospholipid hydroperoxide glutathione peroxidase; protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress; induced by glucose starvation; protein abundance increases in response to DNA replication stress	cellular response to oxidative stress	phospholipid-hydroperoxide glutathione peroxidase activity|glutathione peroxidase activity	extrinsic to mitochondrial inner membrane|extrinsic to mitochondrial outer membrane|nucleus|cytoplasm
YNL243W	YNL243W	SLA2	hom	Verified	1.26139406604562	0.103583452597407	no	541	0.10212210784873	369	NA	FT	VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS|CELL DIVISION|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON		Adaptor protein that links actin to clathrin and endocytosis; involved in membrane cytoskeleton assembly and cell polarization; present in the actin cortical patch of the emerging bud tip; dimer in vivo	bipolar cellular bud site selection|fungal-type cell wall organization|actin filament organization|endocytosis|exocytosis	protein binding, bridging	incipient cellular bud site|mating projection tip|actin cortical patch
YIL052C	YIL052C	RPL34B	hom	Verified	1.2603865819014	0.103764969875114	no	542	0.142517163753738	564	NA	FF|FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L34B; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34B has a paralog, RPL34A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YPR153W	YPR153W	YPR153W	hom	Verified	1.25911903881021	0.103993669318308	no	543	0.0871623452814896	335	NA					Putative protein of unknown function	biological_process	molecular_function	integral to membrane
YKR029C	YKR029C	SET3	hom	Verified	1.25899505347231	0.104016059274194	no	544	0.108856257635246	427	NA	FT	CELL CYCLE|CHROMATIN ORGANIZATION	NUCLEUS|CHROMOSOME		Defining member of the SET3 histone deacetylase complex which is a meiosis-specific repressor of sporulation genes; necessary for efficient transcription by RNAPII; one of two yeast proteins that contains both SET and PHD domains; SET3 has a paralog, SET4, that arose from the whole genome duplication	negative regulation of meiosis|regulation of transcription, DNA-dependent|histone deacetylation	methylated histone residue binding	Rpd3L-Expanded complex|Set3 complex
YDR247W	YDR247W	VHS1	hom	Verified	1.25841779101048	0.104120350536357	no	545	0.0772499853280829	347	NA	FT	CELL CYCLE|PROTEIN PHOSPHORYLATION			Cytoplasmic serine/threonine protein kinase; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; homolog of Sks1p	protein phosphorylation|G1/S transition of mitotic cell cycle	protein serine/threonine kinase activity|protein kinase activity	cytoplasm
YBR248C	YBR248C	HIS7	hom	Verified	1.2577791307681	0.104235822552825	no	546	0.0937090636249113	355	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEOTIDE METABOLISM			Imidazole glycerol phosphate synthase (glutamine amidotransferase:cyclase), catalyzes the fifth step of histidine biosynthesis and also produces 5-aminoimidazole-4-carboxamide ribotide (AICAR), a purine precursor	purine nucleoside monophosphate biosynthetic process|histidine biosynthetic process	imidazoleglycerol-phosphate synthase activity	intracellular
YPL257W_p	YPL257W	YPL257W	hom	Uncharacterized	1.25701305955594	0.104374453333188	no	547	0.109783635331026	407	NA	FT	CELL CYCLE			Putative protein of unknown function; homozygous diploid deletion strain exhibits low budding index; physically interacts with Hsp82p; YPL257W is not an essential gene	biological_process	molecular_function	integral to membrane
YOR158W	YOR158W	PET123	hom	Verified	1.25674255264689	0.10442343706301	no	548	0.116106697032998	427	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the small subunit; PET123 exhibits genetic interactions with PET122, which encodes a COX3 mRNA-specific translational activator	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YOR132W	YOR132W	VPS17	hom	Verified	1.25651409111531	0.10446482013643	no	549	0.102976296934521	442	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM		Subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde protein transport; peripheral membrane protein that assembles onto the membrane with Vps5p to promote vesicle formation; required for recruiting the retromer complex to the endosome membranes	retrograde transport, endosome to Golgi	protein transporter activity|phosphatidylinositol-3-phosphate binding	endosome|retromer complex, outer shell|retromer complex
YPR164W	YPR164W	MMS1	hom	Verified	1.25517586748833	0.104707462005359	no	550	0.106517893141329	471	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS	UBIQUITIN LIGASE COMPLEX	Subunit of an E3 ubiquitin ligase complex involved in replication repair; stabilizes protein components of the replication fork such as the fork-pausing complex and leading strand polymerase, preventing fork collapse and promoting efficient recovery during replication stress; regulates Ty1 transposition; involved with Rtt101p in nonfunctional rRNA decay	replication fork processing|negative regulation of transposition, RNA-mediated|recombinational repair|nonfunctional rRNA decay	molecular_function	Cul8-RING ubiquitin ligase complex
YDR146C	YDR146C	SWI5	hom	Verified	1.25483978135752	0.104768464003411	no	551	0.0854943900814655	343	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE	NUCLEUS		Transcription factor that recruits Mediator and Swi/Snf complexes; activates transcription of genes expressed at the M/G1 phase boundary and in G1 phase; required for expression of the HO gene controlling mating type switching; localization to nucleus occurs during G1 and appears to be regulated by phosphorylation by Cdc28p kinase; SWI5 has a paralog, ACE2, that arose from the whole genome duplication	positive regulation of mating type switching|regulation of transcription involved in G1 phase of mitotic cell cycle|positive regulation of transcription on exit from mitosis, from RNA polymerase II promoter	RNA polymerase II distal enhancer sequence-specific DNA binding|sequence-specific DNA binding|sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity|mediator complex binding	nucleus|cytoplasm
YHR192W	YHR192W	LNP1	hom	Verified	1.25128090818707	0.105416004220161	no	552	0.146235662990751	529	NA					Lunapark family member involved in ER network formation; localizes to ER junctions and this localization is regulated by the yeast atlastin ortholog Sey1p; interacts with the reticulon protein Rtn1p; induced in response to the DNA-damaging agent MMS	endoplasmic reticulum tubular network organization	molecular_function	endoplasmic reticulum tubular network|cytoplasm
YER087W	YER087W	AIM10	hom	Verified	1.2500182162006	0.105646446532357	no	553	0.121426367134062	433	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION	MITOCHONDRION		Protein with similarity to tRNA synthetases; non-tagged protein is detected in purified mitochondria; null mutant is viable and displays elevated frequency of mitochondrial genome loss	biological_process	proline-tRNA ligase activity	mitochondrion
YGL127C	YGL127C	SOH1	hom	Verified	1.24933838372364	0.105770667249629	no	554	0.121164084661506	475	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION	NUCLEUS	RNA POL II, HOLOENZYME	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; involved in telomere maintenance; conserved with other metazoan MED31 subunits	DNA repair|meiotic gene conversion|meiotic sister chromatid segregation|transcription from RNA polymerase II promoter	molecular_function	core mediator complex|nucleus
YML054C-A_p	YML054C-A	YML054C-A	hom	Uncharacterized	1.24543203334854	0.106486492232844	no	555	0.0849769707855872	294	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YLR346C_p	YLR346C	YLR346C	hom	Uncharacterized	1.24500623488943	0.106564729199764	no	556	0.0792991139765623	296	NA	FT		MITOCHONDRION		Putative protein of unknown function found in mitochondria; expression is regulated by transcription factors involved in pleiotropic drug resistance, Pdr1p and Yrr1p; YLR346C is not an essential gene	biological_process	molecular_function	mitochondrion
YNL236W	YNL236W	SIN4	hom	Verified	1.24263776197009	0.107000674030966	no	557	0.144303487528075	563	NA	FF|FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS	RNA POL II, HOLOENZYME	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; contributes to both postive and negative transcriptional regulation; dispensible for basal transcription	negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II transcriptional preinitiation complex assembly|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II activating transcription factor binding	core mediator complex
YIR031C	YIR031C	DAL7	hom	Verified	1.24256766101847	0.107013596493604	no	558	0.111464305964956	460	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM			Malate synthase, role in allantoin degradation unknown; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation	allantoin catabolic process	malate synthase activity	cellular_component
YKR047W_d	YKR047W	YKR047W	hom	Dubious	1.24033702066963	0.107425382411229	no	559	0.127514027281952	475	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NAP1	Unknown	Unknown	Unknown
YOL092W	YOL092W	YPQ1	hom	Verified	1.23975487059086	0.107533037531048	no	560	0.0949314182308258	419	NA					Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; member of the PQ-loop family, with seven transmembrane domains; similar to mammalian PQLC2 vacuolar transporter	biological_process	molecular_function	fungal-type vacuole membrane|integral to membrane|cytoplasm
YNL199C	YNL199C	GCR2	hom	Verified	1.23805571663152	0.107847701122046	no	561	0.124493087933792	481	NA	FT	TRANSCRIPTION FROM RNA POL II|RIBOSOME BIOGENESIS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	ENDOMEMBRANE SYSTEM|NUCLEUS		Transcriptional activator of genes involved in glycolysis; interacts and functions with the DNA-binding protein Gcr1p	positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter|regulation of glycolysis by positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II activating transcription factor binding|RNA polymerase II transcription factor binding transcription factor activity	nuclear envelope|nucleus
YPL179W	YPL179W	PPQ1	hom	Verified	1.2377848113604	0.107897930867248	no	562	0.108627749140933	407	NA	FT	TRANSLATION			Putative protein serine/threonine phosphatase; null mutation enhances efficiency of translational suppressors	protein dephosphorylation|regulation of translation	protein serine/threonine phosphatase activity	cytoplasm
YMR222C	YMR222C	FSH2	hom	Verified	1.23631109651182	0.108171473994113	no	563	0.098069973672416	381	NA					Putative serine hydrolase that localizes to the cytoplasm; sequence is similar to S. cerevisiae Fsh1p and Fsh3p and the human candidate tumor suppressor OVCA2	biological_process	molecular_function	cytoplasm
YGL035C	YGL035C	MIG1	hom	Verified	1.23540246838845	0.10834037730003	no	564	0.125675615679581	473	NA	FT	TRANSCRIPTION FROM RNA POL II|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS	ENDOMEMBRANE SYSTEM|NUCLEUS		Transcription factor involved in glucose repression; sequence specific DNA binding protein containing two Cys2His2 zinc finger motifs; regulated by the SNF1 kinase and the GLC7 phosphatase; regulates filamentous growth along with Mig2p in response to glucose depletion	negative regulation of transcription from RNA polymerase II promoter by glucose|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding	nucleus|nuclear envelope lumen|cytoplasm
YOL158C	YOL158C	ENB1	hom	Verified	1.23329715395679	0.108732459669531	no	565	0.10068362388908	329	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Endosomal ferric enterobactin transporter, expressed under conditions of iron deprivation; member of the major facilitator superfamily; expression is regulated by Rcs1p and affected by chloroquine treatment	ferric-enterobactin transport	ferric-enterobactin transmembrane transporter activity	integral to membrane|cellular bud membrane|plasma membrane
YOR050C_d	YOR050C	YOR050C	hom	Dubious	1.23319347007915	0.108751795523657	no	566	0.0855764400324924	326	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutation is viable	Unknown	Unknown	Unknown
YOL054W	YOL054W	PSH1	hom	Verified	1.23101893093695	0.109157891999514	no	567	0.118563068578058	431	NA	FT	PROTEOLYSIS	NUCLEUS|CHROMOSOME		E3 ubiquitin ligase that mediates poyubiquitination and degradation of centromere-binding protein Cse4p and prevents Cse4p from mislocalizing to euchromatin; ubiquitylation of Cse4p may be antagonized by Scm3p	protein ubiquitination involved in ubiquitin-dependent protein catabolic process	ubiquitin-protein ligase activity	chromosome, centromeric region|nucleus
YPL038W-A_p	YPL038W-A	YPL038W-A	hom	Uncharacterized	1.23077738058869	0.109203068825949	no	568	0.0855499252918962	338	NA					Putative protein of unknown function; identified by fungal homology and RT-PCR	biological_process	molecular_function	cellular_component
YMR017W	YMR017W	SPO20	hom	Verified	1.22917289249041	0.109503495029925	no	569	0.0842518634178099	351	NA	FT		PLASMA MEMBRANE		Meiosis-specific subunit of the t-SNARE complex, required for prospore membrane formation during sporulation; similar to but not functionally redundant with Sec9p; SNAP-25 homolog	ascospore-type prospore assembly	SNAP receptor activity	SNARE complex|prospore membrane
YPL017C	YPL017C	IRC15	hom	Verified	1.22769981752791	0.109779837486114	no	570	0.140243266236051	520	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|OXIDATION-REDUCTION PROCESS|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION	CYTOSKELETON		Microtubule associated protein; regulates microtubule dynamics; required for accurate meiotic chromosome segregation; null mutant displays large budded cells due to delayed mitotic progression, increased levels of spontaneous Rad52 foci	microtubule nucleation|mitotic recombination|microtubule anchoring|meiotic sister chromatid segregation|attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation|positive regulation of mitotic cell cycle	microtubule binding|S-adenosylmethionine-dependent methyltransferase activity	microtubule|cytoplasm
YMR163C	YMR163C	INP2	hom	Verified	1.22636530206615	0.110030618626441	no	571	0.0997289781342624	399	NA	FT	PEROXISOME ORGANIZATION			Peroxisome-specific receptor important for peroxisome inheritance; co-fractionates with peroxisome membranes and co-localizes with peroxisomes in vivo; physically interacts with the myosin V motor Myo2p; INP2 is not an essential gene	peroxisome inheritance	protein anchor	peroxisome|integral to peroxisomal membrane|cytoplasm
YDL020C	YDL020C	RPN4	hom	Verified	1.22459127660134	0.110364628158279	no	572	0.283890138046285	1011	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO DNA DAMAGE|PROTEOLYSIS	NUCLEUS		Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses; relative distribution to the nucleus increases upon DNA replication stress	positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance|regulation of DNA repair|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter in response to stress|positive regulation of transcription from RNA polymerase II promoter in response to stress|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YMR264W	YMR264W	CUE1	hom	Verified	1.22176321866077	0.11089859078952	no	573	0.132242993805784	540	NA	FF|FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|PROTEOLYSIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION	UBIQUITIN LIGASE COMPLEX	Ubiquitin-binding protein; endoplasmic reticulum membrane protein that recruits the ubiquitin-conjugating enzyme Ubc7p to the ER where it functions in protein degradation; contains a CUE domain that binds ubiquitin to facilitate intramolecular monoubiquitination; CUE1 has a paralog, CUE4, that arose from the whole genome duplication	ER-associated protein catabolic process|establishment of protein localization to endoplasmic reticulum membrane	ubiquitin-protein ligase activator activity	Doa10p ubiquitin ligase complex|mitochondrion|integral to endoplasmic reticulum membrane
YPL086C	YPL086C	ELP3	hom	Verified	1.2197698669503	0.111276063716491	no	574	0.127177946287522	498	NA	FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|RNA PROCESSING|CHROMATIN ORGANIZATION	NUCLEUS		Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; exhibits histone acetyltransferase activity that is directed to histones H3 and H4; disruption confers resistance to K. lactis zymotoxin	regulation of transcription from RNA polymerase II promoter|tRNA wobble uridine modification	histone acetyltransferase activity	Elongator holoenzyme complex|nucleus|cytoplasm
YDL081C	YDL081C	RPP1A	hom	Verified	1.21800506008861	0.111611024929156	no	575	0.10765173617156	410	NA	FT	TRANSLATION		RIBOSOME	Ribosomal stalk protein P1 alpha, involved in the interaction between translational elongation factors and the ribosome; accumulation of P1 in the cytoplasm is regulated by phosphorylation and interaction with the P2 stalk component	cytoplasmic translation|translational elongation	structural constituent of ribosome	cytosolic large ribosomal subunit
YGR169C-A_p	YGR169C-A	YGR169C-A	hom	Uncharacterized	1.2171954373872	0.111764932869784	no	576	0.106597699918777	431	NA					Putative protein of unknown function; YGR169C-A has a paralog, YJR005C-A, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YOR106W	YOR106W	VAM3	hom	Verified	1.2169903724093	0.111803939467044	no	577	0.146952797086594	565	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|RESPONSE TO NUTRIENT LEVELS			Syntaxin-like vacuolar t-SNARE that functions with Vam7p in vacuolar protein trafficking; mediates docking/fusion of late transport intermediates with the vacuole; has an acidic di-leucine sorting signal and C-terminal transmembrane region	autophagic vacuole fusion|vesicle fusion with vacuole|piecemeal microautophagy of nucleus|vacuole fusion, non-autophagic|vesicle docking|vesicle fusion	protein homodimerization activity|SNAP receptor activity	SNARE complex|fungal-type vacuole membrane
YKR074W	YKR074W	AIM29	hom	Verified	1.21656740095923	0.111884426068069	no	578	0.106500105826928	414	NA					Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm; YKR074W is not an essential gene; null mutant displays elevated frequency of mitochondrial genome loss	biological_process	molecular_function	cytoplasm
YER046W	YER046W	SPO73	hom	Verified	1.21551413201628	0.112085031068378	no	579	0.101131954643192	345	NA	FT	CELL WALL ORG/BIOGENESIS			Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensible for both nuclear divisions during meiosis	ascospore wall assembly|ascospore formation	molecular_function	cytosol
YJR001W	YJR001W	AVT1	hom	Verified	1.21426833635686	0.11232263635344	no	580	0.149857857538419	544	NA	FT	VACUOLAR TRANSPORT			Vacuolar transporter, imports large neutral amino acids into the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters	amino acid transport|vacuolar transport	transporter activity|L-glutamine transmembrane transporter activity|L-isoleucine transmembrane transporter activity|L-tyrosine transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane|fungal-type vacuole
YOR041C_d	YOR041C	YOR041C	hom	Dubious	1.21326889722543	0.112513515142053	no	581	0.0882514055428973	324	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 85% of ORF overlaps the uncharacterized gene CUE5; deletion in cyr1 mutant results in loss of stress resistance	Unknown	Unknown	Unknown
YIR005W	YIR005W	IST3	hom	Verified	1.21292183890421	0.11257985256069	no	582	0.0997673422102884	407	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RNA LOCALIZATION	NUCLEUS		Component of the U2 snRNP, required for the first catalytic step of splicing and for spliceosomal assembly; interacts with Rds3p and is required for Mer1p-activated splicing	mRNA export from nucleus|spliceosomal complex assembly|mRNA splicing, via spliceosome|generation of catalytic spliceosome for first transesterification step	first spliceosomal transesterification activity	RES complex|U2 snRNP
YLR261C_d	YLR261C	VPS63	hom	Dubious	1.21266130845271	0.112629669223281	no	583	0.21804888115383	707	NA	FF				Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene YPT6; deletion causes a vacuolar protein sorting defect	Unknown	Unknown	Unknown
YPL102C_d	YPL102C	YPL102C	hom	Dubious	1.21196734354554	0.11276244075665	no	584	0.112627744847267	419	NA					Dubious open reading frame, not conserved in closely related Saccharomyces species; deletion mutation enhances replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene ELP4	Unknown	Unknown	Unknown
YGL147C	YGL147C	RPL9A	hom	Verified	1.21175838827765	0.112802440613068	no	585	0.114602133735916	455	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L9A; nearly identical to paralog Rpl9Bp; homologous to mammalian ribosomal protein L9 and bacterial L6	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YJR131W	YJR131W	MNS1	hom	Verified	1.20750141112781	0.113619550974926	no	586	0.11625720350452	362	NA	FT	CARBOHYDRATE METABOLISM|PROTEOLYSIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Alpha-1,2-mannosidase involved in ER-associated protein degradation (ERAD); catalyzes the removal of one mannose residue from a glycosylated protein, converting the modification from Man9GlcNAc to Man8GlcNAc; catalyzes the last step in glycoprotein maturation in the ER and is critical for ER protein degradation	ER-associated protein catabolic process|protein deglycosylation involved in glycoprotein catabolic process	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	endoplasmic reticulum
YER060W	YER060W	FCY21	hom	Verified	1.20600644812866	0.113907502088655	no	587	0.10307968710929	384	NA					Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function	transmembrane transport	nucleobase transmembrane transporter activity	integral to membrane
YGR266W	YGR266W	YGR266W	hom	Verified	1.20547317652591	0.114010343498629	no	588	0.108918980687721	421	NA	FT		MITOCHONDRION|PLASMA MEMBRANE		Protein of unknown function; predicted to contain a single transmembrane domain; mutant has increased aneuploidy tolerance; localized to both the mitochondrial outer membrane and the plasma membrane; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	mitochondrial outer membrane|mitochondrion|plasma membrane
YOR313C	YOR313C	SPS4	hom	Verified	1.20443104848175	0.114211508764476	no	589	0.112578853581021	437	NA	FT	CELL CYCLE			Protein whose expression is induced during sporulation; not required for sporulation; heterologous expression in E. coli induces the SOS response that senses DNA damage	ascospore formation	molecular_function	cellular_component
YLR247C	YLR247C	IRC20	hom	Verified	1.20356934075499	0.114378037752326	no	590	0.0886398246329014	349	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS|MITOCHONDRION		Putative helicase; localizes to the mitochondrion and the nucleus; YLR247C is not an essential gene; null mutant displays increased levels of spontaneous Rad52p foci	double-strand break repair via synthesis-dependent strand annealing	helicase activity	mitochondrion|nucleus
YIR025W	YIR025W	MND2	hom	Verified	1.20319523802757	0.114450388619162	no	591	0.127194752718701	496	NA	FT	CELL CYCLE|CELL DIVISION|PROTEOLYSIS|CHROMOSOME SEGREGATION	NUCLEUS	UBIQUITIN LIGASE COMPLEX	Subunit of the anaphase-promoting complex (APC); necessary for maintaining sister chromatid cohesion in prophase I of meiosis by inhibiting premature ubiquitination and subsequent degradation of substrates by the APC(Ama1) ubiquitin ligase	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|reciprocal meiotic recombination|regulation of mitotic metaphase/anaphase transition|protein ubiquitination|mitotic sister chromatid segregation	molecular_function	nucleus|anaphase-promoting complex
YOR266W	YOR266W	PNT1	hom	Verified	1.20226067719946	0.114631273521338	no	592	0.0860127837116326	305	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial integral inner membrane protein involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18p; deletion mutant sensitive to the anti-Pneumocystis carinii drug pentamidine	protein insertion into mitochondrial membrane from inner side	molecular_function	mitochondrion|integral to mitochondrial inner membrane
YOR363C	YOR363C	PIP2	hom	Verified	1.19918476867835	0.115228054217544	no	593	0.1138718419211	409	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS	NUCLEUS		Autoregulatory oleate-specific transcriptional activator of peroxisome proliferation, contains Zn(2)-Cys(6) cluster domain, forms heterodimer with Oaf1p, binds oleate response elements (OREs), activates beta-oxidation genes; PIP2 has a paralog, OAF1, that arose from the whole genome duplication	cellular response to oleic acid|positive regulation of fatty acid beta-oxidation|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	integral to membrane|nucleus
YHR113W	YHR113W	APE4	hom	Verified	1.19806948842067	0.11544498297593	no	594	0.103971907122558	439	NA	FT	PROTEOLYSIS			Cytoplasmic aspartyl aminopeptidase that may also function in the vacuole; CVT pathway cargo protein; cleaves unblocked N-terminal acidic amino acids from peptide substrates; forms a 12-subunit homo-oligomer; M18 metalloprotease family	proteolysis	aminopeptidase activity	fungal-type vacuole lumen|ribosome|cytoplasm
YAL042C-A_d	YAL042C-A	YAL042C-A	hom	Dubious	1.19573768038562	0.115899471060166	no	595	0.116413758197512	437	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF ERV46/YAL042W; YAL042C-A is a non-essential gene	Unknown	Unknown	Unknown
YIL158W	YIL158W	AIM20	hom	Verified	1.19554787699305	0.115936521099033	no	596	0.122148408744878	450	NA	FT	CELL CYCLE			Putative protein of unknown function; overexpression causes a cell cycle delay or arrest; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; null mutant displays elevated frequency of mitochondrial genome loss; relocalizes from nucleus to cytoplasm upon DNA replication stress	biological_process	molecular_function	fungal-type vacuole
YML116W-A_d	YML116W-A	YML116W-A	hom	Dubious	1.19430019768765	0.116180280168224	no	597	0.0768902734655644	313	NA					Putative protein of unknown function	Unknown	Unknown	Unknown
YOL030W	YOL030W	GAS5	hom	Verified	1.19219186218368	0.11659301179011	no	598	0.112903303773369	425	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM			1,3-beta-glucanosyltransferase, has similarity to Gas1p; localizes to the cell wall	(1->3)-beta-D-glucan metabolic process	1,3-beta-glucanosyltransferase activity	fungal-type cell wall|integral to membrane
YER077C_p	YER077C	YER077C	hom	Uncharacterized	1.1918923592892	0.116651727267028	no	599	0.158973130374339	557	NA	FT		MITOCHONDRION		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; null mutation results in a decrease in plasma membrane electron transport	biological_process	molecular_function	mitochondrion
YKL003C	YKL003C	MRP17	hom	Verified	1.19145135685962	0.116738220912304	no	600	0.125865338182203	438	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the small subunit; MRP17 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YDR344C_d	YDR344C	YDR344C	hom	Dubious	1.19121154976777	0.116785273269669	no	601	0.114019355004466	415	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YKR049C	YKR049C	FMP46	hom	Verified	1.19094181998349	0.116838212798268	no	602	0.104298461249269	400	NA	FT	OXIDATION-REDUCTION PROCESS	MITOCHONDRION		Putative redox protein containing a thioredoxin fold; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	oxidoreductase activity	mitochondrion
YJL047C	YJL047C	RTT101	hom	Verified	1.19055175375264	0.116914800695266	no	603	0.140503876161272	516	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|PROTEOLYSIS	NUCLEUS	UBIQUITIN LIGASE COMPLEX	Cullin subunit of a Roc1p-dependent E3 ubiquitin ligase complex with a role in anaphase progression; implicated in Mms22-dependent DNA repair; involved with Mms1p in nonfunctional rRNA decay; modified by the ubiquitin-like protein, Rub1p	replication fork processing|negative regulation of transposition, RNA-mediated|regulation of mitosis|nonfunctional rRNA decay|ubiquitin-dependent protein catabolic process	ubiquitin-protein ligase activity	Cul8-RING ubiquitin ligase complex|nucleus|cytoplasm
YNL082W	YNL082W	PMS1	hom	Verified	1.19048637610663	0.11692764080752	no	604	0.120244935396127	439	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS		ATP-binding protein required for mismatch repair in mitosis and meiosis; functions as a heterodimer with Mlh1p, binds double- and single-stranded DNA via its N-terminal domain, similar to E. coli MutL	mismatch repair|meiotic mismatch repair	double-stranded DNA binding|DNA insertion or deletion binding|loop DNA binding|single-stranded DNA binding|dinucleotide insertion or deletion binding|ATPase activity|ATP binding	nucleus|MutLalpha complex|cytoplasm
YPL121C	YPL121C	MEI5	hom	Verified	1.18642715952453	0.11772682566445	no	605	0.0897905763328185	321	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Meiosis specific protein involved in DMC1-dependent meiotic recombination, forms heterodimer with Sae3p; proposed to be an assembly factor for Dmc1p	meiotic DNA recombinase assembly|reciprocal meiotic recombination	molecular_function	condensed nuclear chromosome
YCR073W-A	YCR073W-A	SOL2	hom	Verified	1.18531395945778	0.117946668099503	no	606	0.129160272630566	506	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|RNA LOCALIZATION|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS			Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol3p and Sol4p; SOL2 has a paralog, SOL1, that arose from the whole genome duplication	tRNA export from nucleus	molecular_function|6-phosphogluconolactonase activity	cytosol|cytoplasm
YGR273C_p	YGR273C	YGR273C	hom	Uncharacterized	1.18432699247457	0.118141823914403	no	607	0.125493366637289	480	NA					Putative protein of unknown function; expression downregulated by treatment with 8-methoxypsoralen plus UVA irradiation; YGR273C is not an essential gene	biological_process	molecular_function	cellular_component
YCL002C_p	YCL002C	YCL002C	hom	Uncharacterized	1.18411619694601	0.118183534697362	no	608	0.11781773410711	449	NA					Putative protein of unknown function; YCL002C is not an essential gene	biological_process	molecular_function	integral to membrane
YMR319C	YMR319C	FET4	hom	Verified	1.18409103947574	0.118188513381657	no	609	0.186165035404251	683	NA	FF|FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Low-affinity Fe(II) transporter of the plasma membrane	intracellular copper ion transport|zinc ion transport|low-affinity iron ion transport|copper ion import	copper ion transmembrane transporter activity|iron ion transmembrane transporter activity	integral to membrane|plasma membrane|integral to plasma membrane
YDR150W	YDR150W	NUM1	hom	Verified	1.18213550958585	0.118575968298899	no	610	0.166416250775304	624	NA	FT	PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION	MITOCHONDRION|SITE OF POLARIZED GROWTH		Protein required for nuclear migration, localizes to the mother cell cortex and the bud tip; may mediate interactions of dynein and cytoplasmic microtubules with the cell cortex	mitochondrion inheritance|nuclear migration along microtubule|mitochondrial fission|microtubule cytoskeleton organization	tubulin binding	cell cortex|mitochondrion|cellular bud tip
YDR377W	YDR377W	ATP17	hom	Verified	1.1813819649139	0.118725509645709	no	611	0.131722436634025	485	NA	FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS	MITOCHONDRION		Subunit f of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis	ATP synthesis coupled proton transport	hydrogen ion transporting ATP synthase activity, rotational mechanism|ATPase activity|proton-transporting ATPase activity, rotational mechanism	mitochondrion|mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
YOR275C	YOR275C	RIM20	hom	Verified	1.17942782315648	0.119113930741569	no	612	0.112337761140863	444	NA	FT	ION HOMEOSTASIS|PROTEOLYSIS|ION HOMEOSTASIS	NUCLEUS		Protein involved in proteolytic activation of Rim101p in response to alkaline pH; PalA/AIP1/Alix family member; interaction with the ESCRT-III subunit Snf7p suggests a relationship between pH response and multivesicular body formation	proteolysis|response to pH|protein processing|invasive growth in response to glucose limitation|sporulation resulting in formation of a cellular spore	molecular_function	nucleus|cytoplasm
YOL143C	YOL143C	RIB4	hom	Verified	1.17939220191776	0.119121019424303	no	613	0.132089921650329	467	NA	FT		NUCLEUS		Lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, also known as DMRL synthase); catalyzes synthesis of immediate precursor to riboflavin	riboflavin biosynthetic process	6,7-dimethyl-8-ribityllumazine synthase activity	nucleus|cytoplasm
YOR309C_d	YOR309C	YOR309C	hom	Dubious	1.17826876460492	0.119344738049985	no	614	0.144029824108023	500	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NOP58	Unknown	Unknown	Unknown
YIL097W	YIL097W	FYV10	hom	Verified	1.17794318567762	0.119409628439844	no	615	0.125232783289806	493	NA	FT	KETONE METABOLISM|CARBOHYDRATE METABOLISM|PROTEOLYSIS	NUCLEUS		Subunit of GID complex; involved in proteasome-dependent catabolite inactivation of gluconeogenic enzymes FBPase, PEPCK, and c-MDH; forms dimer with Rmd5p that is then recruited to GID Complex by Gid8p; contains a degenerate RING finger motif needed for GID complex ubiquitin ligase activity in vivo, as well as CTLH and CRA domains; plays role in anti-apoptosis; required for survival upon exposure to K1 killer toxin	negative regulation of gluconeogenesis|proteasomal ubiquitin-dependent protein catabolic process|anti-apoptosis	ubiquitin-protein ligase activity	nucleus|GID complex|cytoplasm
YKR018C	YKR018C	YKR018C	hom	Verified	1.17729229760839	0.119539430073699	no	616	0.113692013140785	443	NA	FT		NUCLEUS|MITOCHONDRION		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress; YKR018C has a paralog, IML2, that arose from the whole genome duplication	biological_process	molecular_function	nucleus|cytoplasm
YPL184C	YPL184C	MRN1	hom	Verified	1.17724852722634	0.119548162436922	no	617	0.12240871433065	491	NA	FT	TRANSLATION			RNA-binding protein that may be involved in translational regulation; binds specific categories of mRNAs, including those that contain upstream open reading frames (uORFs) and internal ribosome entry sites (IRES); interacts genetically with chromatin remodelers and splicing factors, linking chromatin state, splicing and as a result mRNA maturation	biological_process	molecular_function	cytoplasm
YMR152W	YMR152W	YIM1	hom	Verified	1.17558452676918	0.119880470847327	no	618	0.119317712565924	462	NA	FT	RESPONSE TO DNA DAMAGE|OXIDATION-REDUCTION PROCESS	MITOCHONDRION		Protein of unknown function; null mutant displays sensitivity to DNA damaging agents; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress	response to DNA damage stimulus	molecular_function	mitochondrion|lipid particle|cytoplasm
YHL013C	YHL013C	OTU2	hom	Verified	1.17406395295729	0.120184705277639	no	619	0.102612114386725	428	NA					Protein of unknown function; may interact with ribosomes, based on co-purification experiments; member of the ovarian tumor-like (OTU) superfamily of predicted cysteine proteases; shows cytoplasmic localization; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	ribosome|cytoplasm
YMR129W	YMR129W	POM152	hom	Verified	1.1738803369649	0.120221479706938	no	620	0.074207163784531	253	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|CYTOSKELETON ORGANIZATION|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION	NUCLEAR PORE	Glycoprotein subunit of the transmembrane ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis and spindle pole body duplication; homologous to human NUP210	nucleocytoplasmic transport|nuclear pore organization|protein import into nucleus|spindle pole body duplication associated with nuclear envelope	protein anchor|structural constituent of nuclear pore	mitochondrion|integral to membrane|nuclear pore transmembrane ring|nuclear envelope lumen|nuclear pore
YPL206C	YPL206C	PGC1	hom	Verified	1.16979605051686	0.121041526715355	no	621	0.11016808981512	433	NA	FT	LIPID METABOLISM|CARBOHYDRATE METABOLISM	MITOCHONDRION		Phosphatidyl Glycerol phospholipase C; regulates the phosphatidylglycerol (PG) content via a phospholipase C-type degradation mechanism; contains glycerophosphodiester phosphodiesterase motifs	glycerophospholipid catabolic process|phosphatidylglycerol catabolic process	phosphatidylglycerol phospholipase C activity	mitochondrion|lipid particle
YER162C	YER162C	RAD4	hom	Verified	1.1696488682499	0.121071151397827	no	622	0.120116812528394	476	NA	FT	RESPONSE TO DNA DAMAGE|PROTEOLYSIS	NUCLEUS		Protein that recognizes and binds damaged DNA (with Rad23p) during nucleotide excision repair; subunit of Nuclear Excision Repair Factor 2 (NEF2); also involved, with Rad23p, in turnover of ubiquitylated proteins	proteasomal ubiquitin-dependent protein catabolic process|nucleotide-excision repair	damaged DNA binding	cytosol|nucleotide-excision repair factor 2 complex|nucleus
YGR093W_p	YGR093W	YGR093W	hom	Uncharacterized	1.1694015437429	0.121120944085127	no	623	0.114990888421006	431	NA	FT		NUCLEUS		Putative protein of unconfirmed function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus	biological_process	molecular_function	nucleus
YMR016C	YMR016C	SOK2	hom	Verified	1.16922978930119	0.121155531078438	no	624	0.0800179467394879	285	NA	FT		NUCLEUS		Nuclear protein that negatively regulates pseudohyphal differentiation; plays a regulatory role in the cyclic AMP (cAMP)-dependent protein kinase (PKA) signal transduction pathway; SOK2 has a paralog, PHD1, that arose from the whole genome duplication	pseudohyphal growth	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	nucleus
YEL031W	YEL031W	SPF1	hom	Verified	1.16774669089091	0.12145447853145	no	625	0.185546475312177	698	NA	FF|FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION|GOLGI APPARATUS		P-type ATPase, ion transporter of the ER membrane; required to maintain normal lipid composition of intracellular compartments and proper targeting of mitochondrial outer membrane tail-anchored proteins; involved in ER function and Ca2+ homeostasis; required for regulating Hmg2p degradation; confers sensitivity to a killer toxin (SMKT) produced by Pichia farinosa KK1	cellular calcium ion homeostasis|transmembrane transport	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism	mitochondrion|integral to membrane|endoplasmic reticulum membrane|cis-Golgi network
YDL227C	YDL227C	HO	hom	Verified	1.16645824076648	0.121714611451171	no	626	0.0845465596006976	345	NA	FT		NUCLEUS		Site-specific endonuclease required for gene conversion at the MAT locus (homothallic switching) through the generation of a ds DNA break; expression restricted to mother cells in late G1 as controlled by Swi4p-Swi6p, Swi5p and Ash1p	mating type switching|gene conversion at mating-type locus, DNA double-strand break formation	endonuclease activity	nucleus
YOR011W	YOR011W	AUS1	hom	Verified	1.16578223939212	0.121851249899708	no	627	0.135499883788543	488	NA	FT	NUCLEOTIDE METABOLISM	MITOCHONDRION|PLASMA MEMBRANE		Plasma membrane sterol transporter of the ATP-binding cassette family; required, along with Pdr11p, for uptake of exogenous sterols and their incorporation into the plasma membrane; activity is stimulated by phosphatidylserine; sterol uptake is required for anaerobic growth because sterol biosynthesis requires oxygen	sterol import	sterol-transporting ATPase activity	mitochondrion|integral to membrane|plasma membrane
YGL198W	YGL198W	YIP4	hom	Verified	1.16514892504971	0.12197935786042	no	628	0.135870460218776	465	NA	FT		ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Protein that interacts with Rab GTPases, localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport	biological_process	Rab GTPase binding	integral to membrane|Golgi apparatus
YFR014C	YFR014C	CMK1	hom	Verified	1.16485205896723	0.122039441016137	no	629	0.0949002190388751	300	NA	FT	SIGNALING|PROTEIN PHOSPHORYLATION			Calmodulin-dependent protein kinase; may play a role in stress response, many Ca++/calmodulin dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to mammalian Cam Kinase II; CMK1 has a paralog, CMK2, that arose from the whole genome duplication	signal transduction|protein phosphorylation	protein kinase activity|calmodulin-dependent protein kinase activity	cytoplasm
YMR181C_p	YMR181C	YMR181C	hom	Uncharacterized	1.16434899760208	0.12214130377809	no	630	0.117218771541854	393	NA					Protein of unknown function; mRNA transcribed as part of a bicistronic transcript with a predicted transcriptional repressor RGM1/YMR182C; mRNA is destroyed by nonsense-mediated decay (NMD); not an essential gene; YMR181C has a paralog, YPL229W, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YJR142W_p	YJR142W	YJR142W	hom	Uncharacterized	1.1627640685104	0.122462619613141	no	631	0.11387728347963	469	NA					Putative protein of unknown function; GST fusion protein is a Dbf2p-Mob1p phosphorylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition; nudix hydrolase family member	biological_process	molecular_function	cellular_component
YOR025W	YOR025W	HST3	hom	Verified	1.16265713830431	0.122484319126521	no	632	0.119011295575708	452	NA	FT	KETONE METABOLISM|LIPID METABOLISM|CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS		Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst4p in telomeric silencing, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism	short-chain fatty acid metabolic process|histone deacetylation|chromatin silencing at telomere	histone deacetylase activity|DNA binding	nucleus
YPL071C_p	YPL071C	YPL071C	hom	Uncharacterized	1.16150089227869	0.122719130263581	no	633	0.109257941368043	367	NA	FT		NUCLEUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus	biological_process	molecular_function	nucleus|cytoplasm
YLR004C	YLR004C	THI73	hom	Verified	1.16111202476257	0.122798172617454	no	634	0.103231754193467	331	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|PLASMA MEMBRANE		Putative plasma membrane permease proposed to be involved in carboxylic acid uptake and repressed by thiamine; substrate of Dbf2p/Mob1p kinase; transcription is altered if mitochondrial dysfunction occurs	transport	transporter activity	integral to membrane|endoplasmic reticulum
YLR057W	YLR057W	MNL2	hom	Verified	1.16073065811311	0.122875724994065	no	635	0.13678611392687	479	NA	FT	PROTEOLYSIS	ENDOPLASMIC RETICULUM		Putative mannosidase involved in ER-associated protein degradation; localizes to the endoplasmic reticulum; sequence similarity with seven-hairpin glycosidase (GH47) family members, such as Mns1p and Mnl1p, that hydrolyze 1,2-linked alpha-D-mannose residues; non-essential gene	ER-associated protein catabolic process	molecular_function	endoplasmic reticulum
YIL164C	YIL164C	NIT1	hom	Verified	1.16066203494311	0.12288968342502	no	636	0.104211231193909	421	NA					Nitrilase, member of the nitrilase branch of the nitrilase superfamily; in closely related species and other S. cerevisiae strain backgrounds YIL164C and adjacent ORF, YIL165C, likely constitute a single ORF encoding a nitrilase gene	biological_process	nitrilase activity	cellular_component
YMR116C	YMR116C	ASC1	hom	Verified	1.15923397149201	0.123180413827713	no	637	0.128061842508217	501	NA	FT	SIGNALING|TRANSLATION		RIBOSOME	G-protein beta subunit and guanine nucleotide dissociation inhibitor for Gpa2p; ortholog of RACK1 that inhibits translation; core component of the small (40S) ribosomal subunit; regulates P-body formation induced by replication stress; represses Gcn4p in the absence of amino acid starvation	negative regulation of translation|glucose mediated signaling pathway|G-protein coupled receptor signaling pathway|invasive growth in response to glucose limitation	G-protein alpha-subunit binding|GDP-dissociation inhibitor activity|signal transducer activity	cytosolic small ribosomal subunit|cytoplasm
YHL031C	YHL031C	GOS1	hom	Verified	1.15870261347267	0.123288712592605	no	638	0.20180726121568	722	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		v-SNARE protein involved in Golgi transport, homolog of the mammalian protein GOS-28/GS28	Golgi vesicle transport|vesicle fusion	SNAP receptor activity	SNARE complex|integral to membrane|Golgi medial cisterna
YPL084W	YPL084W	BRO1	hom	Verified	1.15824393775387	0.123382251247296	no	639	0.129490841597944	513	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEOLYSIS|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS			Cytoplasmic class E vacuolar protein sorting (VPS) factor that coordinates deubiquitination in the multivesicular body (MVB) pathway by recruiting Doa4p to endosomes	protein deubiquitination|vacuolar transport|protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|response to nutrient|ubiquitin-dependent protein catabolic process	ubiquitin-specific protease activity	endosome|cytoplasm
YNL035C	YNL035C	YNL035C	hom	Verified	1.15741607347422	0.123551205087555	no	640	0.102183060679038	363	NA	FT		NUCLEUS		Protein of unknown function; contains WD-40 domains; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YNL035C is not an essential gene; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	nucleus
YOR293C-A_p	YOR293C-A	YOR293C-A	hom	Uncharacterized	1.15338689284383	0.124375809454813	no	641	0.105206324111599	349	NA					Putative protein of unknown function; identified by expression profiling and mass spectrometry	biological_process	molecular_function	cellular_component
YJR055W	YJR055W	HIT1	hom	Verified	1.15257107555511	0.124543240505016	no	642	0.0928094022421809	387	NA	FT		NUCLEUS		Protein of unknown function, required for growth at high temperature	biological_process	molecular_function	nucleus|cytoplasm
YDL076C	YDL076C	RXT3	hom	Verified	1.1504159518356	0.124986296554759	no	643	0.137909739520948	472	NA	FT	CHROMATIN ORGANIZATION	NUCLEUS|CHROMOSOME		Subunit of the RPD3L complex; involved in histone deacetylation; protein abundance increases in response to DNA replication stress	negative regulation of transcription from RNA polymerase I promoter	molecular_function	Rpd3L-Expanded complex|nucleus|Rpd3L complex
YKR070W_p	YKR070W	YKR070W	hom	Uncharacterized	1.14987359358194	0.125097969195329	no	644	0.12317783552348	438	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YPL070W	YPL070W	MUK1	hom	Verified	1.14963583470347	0.125146946183597	no	645	0.111785795181532	407	NA					Cytoplasmic protein of unknown function containing a Vps9 domain; computational analysis of large-scale protein-protein interaction data suggests a possible role in transcriptional regulation	biological_process	molecular_function	cytoplasm
YHR185C	YHR185C	PFS1	hom	Verified	1.14871823056786	0.125336093019823	no	646	0.134763041153428	473	NA	FT	CELL WALL ORG/BIOGENESIS	NUCLEUS|CYTOSKELETON		Sporulation protein required for prospore membrane formation at selected spindle poles, ensures functionality of all four spindle pole bodies during meiosis II; not required for meiotic recombination or meiotic chromosome segregation	ascospore wall assembly	molecular_function	cellular_component
YJL112W	YJL112W	MDV1	hom	Verified	1.14602711594712	0.125891966258655	no	647	0.146885369581505	528	NA	FT	MITOCHONDRION ORGANIZATION|PEROXISOME ORGANIZATION	MITOCHONDRION		Peripheral protein of cytosolic face of mitochondrial outer membrane; required for mitochondrial fission; interacts with Fis1p and with the dynamin-related GTPase Dnm1p; contains WD repeats; MDV1 has a paralog, CAF4, that arose from the whole genome duplication	peroxisome fission|mitochondrial fission|mitochondrial genome maintenance	ubiquitin binding	mitochondrial outer membrane|mitochondrion
YNL289W	YNL289W	PCL1	hom	Verified	1.141482276054	0.126834641758453	no	648	0.132873316132013	459	NA	FT	CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Cyclin, interacts with cyclin-dependent kinase Pho85p; member of the Pcl1,2-like subfamily, involved in the regulation of polarized growth and morphogenesis and progression through the cell cycle; is ubiquitinated by Dma1p; phosphorylation by Pho85p targets it for degradation; localizes to sites of polarized cell growth	regulation of establishment or maintenance of cell polarity|G1 phase of mitotic cell cycle|regulation of cyclin-dependent protein kinase activity|septin ring organization|positive regulation of macroautophagy	cyclin-dependent protein kinase regulator activity	cyclin-dependent protein kinase holoenzyme complex|incipient cellular bud site|nucleus
YIL008W	YIL008W	URM1	hom	Verified	1.14079558826213	0.126977498479747	no	649	0.135019818513315	512	NA	FT	RNA PROCESSING|CELL DIVISION|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		Ubiquitin-like protein involved in thiolation of cytoplasmic tRNAs; receives sulfur from the E1-like enzyme Uba4p and transfers it to tRNA; also functions as a protein tag with roles in nutrient sensing and oxidative stress response	cellular response to oxidative stress|tRNA wobble position uridine thiolation|cell budding|protein urmylation|invasive growth in response to glucose limitation|tRNA wobble uridine modification	protein tag	cytosol|nucleus|cytoplasm
YAL067W-A_p	YAL067W-A	YAL067W-A	hom	Uncharacterized	1.13870980139018	0.127412106654717	no	650	0.115780369319318	438	NA					Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching	biological_process	molecular_function	cellular_component
YBR106W	YBR106W	PHO88	hom	Verified	1.1385628520041	0.127442764952107	no	651	0.204565253377843	742	NA	FF|FT	ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Probable membrane protein, involved in phosphate transport; pho88 pho86 double null mutant exhibits enhanced synthesis of repressible acid phosphatase at high inorganic phosphate concentrations	phosphate ion transport	molecular_function	mitochondrion|membrane
YHR147C	YHR147C	MRPL6	hom	Verified	1.13849165098209	0.127457621585937	no	652	0.150102110004023	542	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YER091C	YER091C	MET6	hom	Verified	1.13833886832365	0.127489504912465	no	653	0.0706503217305524	275	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Cobalamin-independent methionine synthase, involved in methionine biosynthesis and regeneration; requires a minimum of two glutamates on the methyltetrahydrofolate substrate, similar to bacterial metE homologs	methionine biosynthetic process	5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity	plasma membrane|cytoplasm
YOL076W	YOL076W	MDM20	hom	Verified	1.13804186930567	0.127551499782633	no	654	0.165361517059558	635	NA	FF|FT	MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION			Non-catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes N-acetylation of proteins with specific N-terminal sequences; involved in mitochondrial inheritance and actin assembly	mitochondrion inheritance|N-terminal peptidyl-methionine acetylation|cytoskeleton organization	peptide alpha-N-acetyltransferase activity	NatB complex
YLR392C	YLR392C	ART10	hom	Verified	1.13743704389542	0.127677814402028	no	655	0.0923971685994055	370	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION			Protein of unknown function that contains 2 PY motifs and is ubiquinated by Rsp5p; overexpression confers resistance to arsenite; green fluorescent protein (GFP)-fusion protein localizes it to the cytoplasm; non-essential gene	biological_process	molecular_function	cytoplasm
YNL155W	YNL155W	YNL155W	hom	Verified	1.13354908922544	0.128491869379399	no	656	0.108819588543355	427	NA	FT		NUCLEUS		Protein of unknown function; contains a DHHC domain and an AN1-type zinc finger; predicted to have thiol-disulfide oxidoreductase active site; transcriptionally regulated by Rpn4p along with proteasome subunit genes; putative ortholog of human AIRAP, which stimulates proteasome activity in response to arsenic; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	nucleus|cytoplasm
YJR051W	YJR051W	OSM1	hom	Verified	1.13303082031071	0.128600655380213	no	657	0.118490133691742	442	NA	FT	OXIDATION-REDUCTION PROCESS	MITOCHONDRION		Fumarate reductase, catalyzes the reduction of fumarate to succinate; required for the reoxidation of intracellular NADH under anaerobic conditions; mutations cause osmotic sensitivity; OSM1 has a paralog, FRD1, that arose from the whole genome duplication	cellular response to anoxia	fumarate reductase (NADH) activity	mitochondrion
YDL068W_d	YDL068W	YDL068W	hom	Dubious	1.1330108650465	0.128604845319862	no	658	0.15443768205502	560	NA					Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YER086W	YER086W	ILV1	hom	Verified	1.13287712142026	0.128632929463999	no	659	0.161997905033167	578	NA	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		Threonine deaminase, catalyzes the first step in isoleucine biosynthesis; expression is under general amino acid control; ILV1 locus exhibits highly positioned nucleosomes whose organization is independent of known ILV1 regulation	threonine catabolic process|isoleucine biosynthetic process	L-threonine ammonia-lyase activity	mitochondrion
YOR055W_d	YOR055W	YOR055W	hom	Dubious	1.13235817491717	0.128741940693782	no	660	0.112059283722103	444	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YKR019C	YKR019C	IRS4	hom	Verified	1.1323476497776	0.128744152294473	no	661	0.304546293150676	1080	NA	FF|FT	LIPID METABOLISM|SIGNALING|CELL WALL ORG/BIOGENESIS|RESPONSE TO NUTRIENT LEVELS|GENE SILENCING	MITOCHONDRION		EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; IRS4 has a paralog, TAX4, that arose from the whole genome duplication	autophagy|fungal-type cell wall organization|chromatin silencing at rDNA|inositol lipid-mediated signaling|CVT pathway|cellular response to starvation	molecular_function	mitochondrion|pre-autophagosomal structure
YNL049C	YNL049C	SFB2	hom	Verified	1.13099147028183	0.129029340782456	no	662	0.11378182895752	422	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Component of the Sec23p-Sfb2p heterodimer of the COPII vesicle coat, required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sec24p and Sfb3p	cargo loading into COPII-coated vesicle	signal sequence binding	COPII vesicle coat
YML034C-A_d	YML034C-A	YML034C-A	hom	Dubious	1.13002679994708	0.129232465963877	no	663	0.145079793200395	550	NA					Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YPL139C	YPL139C	UME1	hom	Verified	1.12870914873834	0.129510274322711	no	664	0.131047922210238	515	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS|CHROMOSOME		Negative regulator of meiosis, required for repression of a subset of meiotic genes during vegetative growth, binding of histone deacetylase Rpd3p required for activity, contains a NEE box and a WD repeat motif; homologous with Wtm1p, Wtm2p	positive regulation of transcription from RNA polymerase II promoter in response to heat stress|negative regulation of transcription from RNA polymerase I promoter|negative regulation of chromatin silencing at telomere|positive regulation of transcription from RNA polymerase II promoter|regulation of meiosis	transcription corepressor activity	Rpd3S complex|Rpd3L-Expanded complex|nucleus|Rpd3L complex
YDL099W	YDL099W	BUG1	hom	Verified	1.12844064709878	0.12956693485211	no	665	0.0957217816179097	375	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	GOLGI APPARATUS		Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes	protein secretion|ER to Golgi vesicle-mediated transport	molecular_function	cis-Golgi network|cytoplasm
YOR320C	YOR320C	GNT1	hom	Verified	1.12706691576826	0.129857095029948	no	666	0.12373306544567	431	NA	FT	CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		N-acetylglucosaminyltransferase capable of modification of N-linked glycans in the Golgi apparatus	protein N-linked glycosylation	acetylglucosaminyltransferase activity	Golgi medial cisterna
YLR309C	YLR309C	IMH1	hom	Verified	1.12682832333687	0.129907536456209	no	667	0.112778360561749	431	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Protein involved in vesicular transport, mediates transport between an endosomal compartment and the Golgi, contains a Golgi-localization (GRIP) domain that interacts with activated Arl1p-GTP to localize Imh1p to the Golgi	Golgi to plasma membrane protein transport|vesicle-mediated transport	molecular_function	cytosol|Golgi apparatus
YPR160W	YPR160W	GPH1	hom	Verified	1.12637166435082	0.130004117704685	no	668	0.10247795755479	378	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY			Non-essential glycogen phosphorylase required for the mobilization of glycogen, activity is regulated by cyclic AMP-mediated phosphorylation, expression is regulated by stress-response elements and by the HOG MAP kinase pathway	glycogen catabolic process	glycogen phosphorylase activity	cytoplasm
YPL021W	YPL021W	ECM23	hom	Verified	1.12619552714441	0.130041383182535	no	669	0.105080945992293	395	NA	FT	CELL WALL ORG/BIOGENESIS			Non-essential protein of unconfirmed function; affects pre-rRNA processing, may act as a negative regulator of the transcription of genes involved in pseudohyphal growth; homologous to Srd1p	pseudohyphal growth	sequence-specific DNA binding	cellular_component
YFR012W-A_p	YFR012W-A	YFR012W-A	hom	Uncharacterized	1.12556190354656	0.130175500526009	no	670	0.094978368695477	385	NA					Putative protein of unknown function; identified by homology	biological_process	molecular_function	cellular_component
YHR047C	YHR047C	AAP1	hom	Verified	1.12377669107672	0.130553886097322	no	671	0.117103052638349	407	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|PROTEOLYSIS|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS		Arginine/alanine amino peptidase; overproduction stimulates glycogen accumulation; AAP1 has a paralog, APE2, that arose from the whole genome duplication	glycogen metabolic process|proteolysis	aminopeptidase activity	nucleus|cytoplasm
YLR030W_p	YLR030W	YLR030W	hom	Uncharacterized	1.12361840218206	0.130587472966407	no	672	0.116013883831499	433	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YOL013C	YOL013C	HRD1	hom	Verified	1.12153002605116	0.13103115898772	no	673	0.103857738752449	437	NA	FT	CELL WALL ORG/BIOGENESIS|PROTEOLYSIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	UBIQUITIN LIGASE COMPLEX	Ubiquitin-protein ligase; required for endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins; genetically linked to the unfolded protein response (UPR); regulated through association with Hrd3p; contains an H2 ring finger; likely plays a general role in targeting proteins that persistently associate with and potentially obstruct the ER-localized translocon	fungal-type cell wall organization|ER-associated protein catabolic process	ubiquitin-protein ligase activity	Hrd1p ubiquitin ligase ERAD-M complex|integral to membrane|Hrd1p ubiquitin ligase ERAD-L complex|endoplasmic reticulum membrane
YDR399W	YDR399W	HPT1	hom	Verified	1.1211270812576	0.131116886359888	no	674	0.117617289389668	433	NA	FT	NUCLEOTIDE METABOLISM	NUCLEUS		Dimeric hypoxanthine-guanine phosphoribosyltransferase, catalyzes the transfer of the phosphoribosyl portion of 5-phosphoribosyl-alpha-1-pyrophosphate to a purine base (either guanine or hypoxanthine) to form pyrophosphate and a purine nucleotide (either guanosine monophosphate or inosine monophosphate); mutations in the human homolog HPRT1 can cause Lesch-Nyhan syndrome and Kelley-Seegmiller syndrome	GMP salvage|IMP salvage	hypoxanthine phosphoribosyltransferase activity	nucleus|cytoplasm
YNL249C	YNL249C	MPA43	hom	Verified	1.11990099900423	0.131377976269905	no	675	0.141001785342989	497	NA	FT	CARBOHYDRATE METABOLISM	MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YGR033C	YGR033C	TIM21	hom	Verified	1.11970370832711	0.131420022131747	no	676	0.119673558222989	427	NA	FT	PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Nonessential subunit of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); interacts with the Translocase of the Outer Mitochondrial membrane (TOM complex) and with respiratory enzymes; may regulate TIM23 complex activity	protein import into mitochondrial matrix	molecular_function	mitochondrion|mitochondrial inner membrane presequence translocase complex
YGR056W	YGR056W	RSC1	hom	Verified	1.11728147583564	0.131936996657412	no	677	0.205745365713556	723	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE	NUCLEUS	RSC COMPLEX	Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; contains two essential bromodomains, a bromo-adjacent homology (BAH) domain, and an AT hook	double-strand break repair|ATP-dependent chromatin remodeling|regulation of sporulation resulting in formation of a cellular spore|double-strand break repair via nonhomologous end joining|nucleosome disassembly|transcription elongation from RNA polymerase II promoter	DNA-dependent ATPase activity	RSC complex
YKL079W	YKL079W	SMY1	hom	Verified	1.11449289603002	0.132533895201084	no	678	0.111076571156354	405	NA	FT	VESICLE-MEDIATED TRANSPORT	SITE OF POLARIZED GROWTH|CYTOSKELETON		Protein that interacts with Myo2p, proposed to be involved in exocytosis; N-terminal domain is related to the motor domain of kinesins	exocytosis	motor activity	incipient cellular bud site|cellular bud neck|mating projection tip|cellular bud tip
YDR158W	YDR158W	HOM2	hom	Verified	1.11248649425392	0.132964516950017	no	679	0.158738722236967	589	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS	NUCLEUS		Aspartic beta semi-aldehyde dehydrogenase, catalyzes the second step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis	methionine biosynthetic process|threonine biosynthetic process|homoserine biosynthetic process	aspartate-semialdehyde dehydrogenase activity	nucleus|plasma membrane|cytoplasm
YBR146W	YBR146W	MRPS9	hom	Verified	1.10907440282481	0.133699043162421	no	680	0.143685071476677	512	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the small subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YOR094W	YOR094W	ARF3	hom	Verified	1.10870257981396	0.133779254316927	no	681	0.103815235576191	363	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL CYCLE|LIPID METABOLISM|MEMBRANE ORGANIZATION|SIGNALING|CELL DIVISION|CYTOSKELETON ORGANIZATION	GOLGI APPARATUS|SITE OF POLARIZED GROWTH		Glucose-repressible ADP-ribosylation factor, GTPase of the Ras superfamily involved in development of polarity; also has mRNA binding activity	intracellular protein transport|positive regulation of phosphatidylinositol biosynthetic process|endocytosis|actin filament bundle assembly|actin cortical patch localization|cellular bud site selection	mRNA binding|GTPase activity	cellular bud neck|cellular bud tip
YDR265W	YDR265W	PEX10	hom	Verified	1.10712634448296	0.13411965344785	no	682	0.132062396275978	495	NA	FT	PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION			Peroxisomal membrane E3 ubiquitin ligase, required for for Ubc4p-dependent Pex5p ubiquitination and peroxisomal matrix protein import; contains zinc-binding RING domain; mutations in human homolog cause various peroxisomal disorders	protein import into peroxisome matrix|protein ubiquitination	ubiquitin-protein ligase activity|protein binding	peroxisomal membrane
YDR511W	YDR511W	ACN9	hom	Verified	1.10603873301639	0.134354877453589	no	683	0.103499603401352	358	NA	FT	KETONE METABOLISM|CARBOHYDRATE METABOLISM	MITOCHONDRION		Protein of the mitochondrial intermembrane space, required for acetate utilization and gluconeogenesis; has orthologs in higher eukaryotes	carbon utilization|regulation of gluconeogenesis	molecular_function	mitochondrion|mitochondrial intermembrane space
YPR095C	YPR095C	SYT1	hom	Verified	1.1058432685943	0.134397181684274	no	684	0.140456291249976	490	NA	FT	VESICLE-MEDIATED TRANSPORT|SIGNALING	MITOCHONDRION|GOLGI APPARATUS		Guanine nucleotide exchange factor (GEF) for Arf proteins; promotes activation of Arl1p, which recruits Imh1p to the Golgi; involved in vesicular transport; member of the Sec7-domain family; contains a PH domain	vesicle-mediated transport|exocytosis|positive regulation of ARF protein signal transduction	ARF guanyl-nucleotide exchange factor activity	mitochondrion|Golgi apparatus part
YPL272C_p	YPL272C	YPL272C	hom	Uncharacterized	1.10492835218509	0.134595318005467	no	685	0.16169481402561	587	NA					Putative protein of unknown function; gene expression induced in response to ketoconazole; YPL272C is not an essential gene	biological_process	molecular_function	cellular_component
YNR023W	YNR023W	SNF12	hom	Verified	1.10367265015762	0.134867581890725	no	686	0.291374858593107	978	NA	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS	NUCLEUS	RSC COMPLEX	73 kDa subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; homolog of Rsc6p subunit of the RSC chromatin remodeling complex; relocates to the cytosol under hypoxic conditions; deletion mutants are temperature-sensitive	positive regulation of transcription from RNA polymerase II promoter in response to amino acid starvation|positive regulation of transcription from RNA polymerase II promoter	molecular_function	SWI/SNF complex
YLR369W	YLR369W	SSQ1	hom	Verified	1.10324501783952	0.134960388190761	no	687	0.132630171199856	481	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|COFACTOR METABOLISM	MITOCHONDRION		Mitochondrial hsp70-type molecular chaperone, required for assembly of iron/sulfur clusters into proteins at a step after cluster synthesis, and for maturation of Yfh1p, which is a homolog of human frataxin implicated in Friedreich's ataxia	iron-sulfur cluster assembly|intracellular sequestering of iron ion|protein maturation	unfolded protein binding	mitochondrion|mitochondrial matrix
YMR272C	YMR272C	SCS7	hom	Verified	1.10298462913888	0.13501692013299	no	688	0.147082823823112	528	NA	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Sphingolipid alpha-hydroxylase, functions in the alpha-hydroxylation of sphingolipid-associated very long chain fatty acids, has both cytochrome b5-like and hydroxylase/desaturase domains, not essential for growth	inositolphosphoceramide metabolic process	fatty acid alpha-hydroxylase activity	integral to membrane|endoplasmic reticulum|membrane
YHL043W	YHL043W	ECM34	hom	Verified	1.10255379345115	0.135110492796491	no	689	0.110896661187792	391	NA	FT	CELL WALL ORG/BIOGENESIS			Putative protein of unknown function; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins	fungal-type cell wall organization	molecular_function	cellular_component
YNL265C	YNL265C	IST1	hom	Verified	1.10188210475318	0.135256464713405	no	690	0.146882120054198	545	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT			Protein with a positive role in the multivesicular body sorting pathway; functions and forms a complex with Did2p; recruitment to endosomes is mediated by the Vps2p-Vps24p subcomplex of ESCRT-III; also interacts with Vps4p	late endosome to vacuole transport via multivesicular body sorting pathway	molecular_function	endosome|cytoplasm
YPL095C	YPL095C	EEB1	hom	Verified	1.10046793543425	0.135564146428467	no	691	0.152412856867249	550	NA	FT	KETONE METABOLISM|LIPID METABOLISM			Acyl-coenzymeA:ethanol O-acyltransferase; responsible for the major part of medium-chain fatty acid ethyl ester biosynthesis during fermentation; possesses short-chain esterase activity; may be involved in lipid metabolism and detoxification; EEB1 has a paralog, EHT1, that arose from the whole genome duplication	medium-chain fatty acid catabolic process|medium-chain fatty acid biosynthetic process	short-chain carboxylesterase activity|alcohol O-octanoyltransferase activity	cellular_component
YDR173C	YDR173C	ARG82	hom	Verified	1.09986387718336	0.135695717818521	no	692	0.136292071056356	516	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|LIPID METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Inositol polyphosphate multikinase (IPMK), sequentially phosphorylates Ins(1,4,5)P3 to form Ins(1,3,4,5,6)P5; also has diphosphoinositol polyphosphate synthase activity; regulates arginine-, phosphate-, and nitrogen-responsive genes	protein stabilization|negative regulation of transcription from RNA polymerase II promoter|phosphatidylinositol phosphorylation|regulation of arginine metabolic process|inositol phosphate biosynthetic process|positive regulation of transcription from RNA polymerase II promoter	inositol-1,4,5-trisphosphate 3-kinase activity|inositol-1,4,5-trisphosphate 6-kinase activity|phosphatidylinositol 3-kinase activity|protein binding, bridging|inositol tetrakisphosphate 6-kinase activity|inositol tetrakisphosphate 3-kinase activity|inositol-1,3,4,5,6-pentakisphosphate kinase activity	nucleus
YGR064W_d	YGR064W	YGR064W	hom	Dubious	1.09956630024622	0.135760565919898	no	693	0.221889088371153	737	NA	FF				Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SPT4/YGR063C	Unknown	Unknown	Unknown
YGL076C	YGL076C	RPL7A	hom	Verified	1.09940685855568	0.135795320257132	no	694	0.12784677768524	449	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L7A; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2); homologous to mammalian ribosomal protein L7 and bacterial L30; RPL7A has a paralog, RPL7B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit|cytoplasm
YOL086W-A	YOL086W-A	MHF1	hom	Verified	1.09645237374471	0.136440427383438	no	695	0.102097895171535	418	NA	FT	RESPONSE TO DNA DAMAGE			Component of the heterotetrameric MHF histone-fold complex; in humans the MMF complex interacts with both DNA and Mph1p ortholog FANCM, a Fanconi anemia complementation group protein, to stabilize and remodel blocked replication forks and repair damaged DNA; mhf1 srs2 double mutants are MMS hypersensitive; ortholog of human centromere constitutive-associated network (CCAN) subunit CENP-S, also known as MHF1	response to DNA damage stimulus	molecular_function	cellular_component
YJL055W_p	YJL055W	YJL055W	hom	Uncharacterized	1.09586538025088	0.136568845703909	no	696	0.138991019200344	518	NA	FT		NUCLEUS		Putative protein of unknown function, proposed to be involved in the metabolism of purine and pyrimidine base analogues; deletion mutants are sensitive to HAP and AHA; overexpression confers resistance to 5-FOA and 5-FU	response to chemical stimulus|response to purine-containing compound	molecular_function	nucleus|cytoplasm
YNL058C_p	YNL058C	YNL058C	hom	Uncharacterized	1.09523030457191	0.13670787617199	no	697	0.119975452529637	479	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YNL058C is not an essential gene	biological_process	molecular_function	fungal-type vacuole
YIL072W	YIL072W	HOP1	hom	Verified	1.09466409363936	0.136831912372941	no	698	0.169776834923989	566	NA	FT	CELL CYCLE	NUCLEUS|CHROMOSOME		Meiosis-specific protein required for chromosome synapsis; displays Red1p dependent localization to the unsynapsed axial-lateral elements of the synaptonemal complex; required for chiasma formation; in vitro, displays the ability to promote intra- and intermolecular synapsis between double-stranded DNA molecules and to fold DNA into rigid protein?DNA filaments	synaptonemal complex assembly|meiotic recombination checkpoint|synapsis	four-way junction DNA binding	condensed nuclear chromosome|lateral element
YBR130C	YBR130C	SHE3	hom	Verified	1.09410974398279	0.136953424703291	no	699	0.141194922450723	485	NA	FT	RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|SITE OF POLARIZED GROWTH|CYTOSKELETON		Protein that acts as an adaptor between Myo4p and the She2p-mRNA complex; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud; also required for cortical ER inheritance	mating type switching|endoplasmic reticulum inheritance|intracellular mRNA localization	mRNA binding	actin cap|cytoplasm|cellular bud tip
YPL130W	YPL130W	SPO19	hom	Verified	1.09334869367105	0.137120365483136	no	700	0.110291705159314	384	NA	FT	CELL CYCLE|MEMBRANE ORGANIZATION			Meiosis-specific prospore protein; required to produce bending force necessary for proper assembly of the prospore membrane during sporulation; identified as a weak high-copy suppressor of the spo1-1 ts mutation	meiosis|spore membrane bending pathway	molecular_function	fungal-type cell wall|prospore membrane
YOL017W	YOL017W	ESC8	hom	Verified	1.0926343764785	0.137277181513009	no	701	0.138481239427516	480	NA	FT	GENE SILENCING	NUCLEUS		Protein involved in telomeric and mating-type locus silencing; interacts with Sir2p and also interacts with Gal11p, which is a component of the RNA pol II mediator complex; ESC8 has a paralog, IOC3, that arose from the whole genome duplication	chromatin silencing	molecular_function	nucleus
YDR251W	YDR251W	PAM1	hom	Verified	1.09195533798455	0.13742636623172	no	702	0.128274200662414	447	NA	FT	OXIDATION-REDUCTION PROCESS	SITE OF POLARIZED GROWTH		Essential protein of unknown function; exhibits variable expression during colony morphogenesis; overexpression permits survival without protein phosphatase 2A, inhibits growth, and induces a filamentous phenotype	pseudohyphal growth	molecular_function	cellular bud|cellular bud neck
YMR295C	YMR295C	YMR295C	hom	Verified	1.09156702025669	0.137511729348751	no	703	0.129170656992472	446	NA	FT		SITE OF POLARIZED GROWTH		Protein of unknown function that associates with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and bud; YMR295C is not an essential gene; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	ribosome|cellular bud|mating projection tip
YIR014W_p	YIR014W	YIR014W	hom	Uncharacterized	1.09032797951601	0.137784347204346	no	704	0.121324044445954	402	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p; YIR014W is a non-essential gene	biological_process	molecular_function	fungal-type vacuole
YGR080W	YGR080W	TWF1	hom	Verified	1.08874384984234	0.138133429488415	no	705	0.125386651269992	472	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Twinfilin, highly conserved actin monomer-sequestering protein involved in regulation of the cortical actin cytoskeleton, composed of two cofilin-like regions, localizes actin monomers to sites of rapid filament assembly	bipolar cellular bud site selection|actin polymerization or depolymerization|sequestering of actin monomers	actin monomer binding	mating projection tip|actin cortical patch
YOL050C_d	YOL050C	YOL050C	hom	Dubious	1.0871587670781	0.138483324927145	no	706	0.157400608989689	565	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps verified gene GAL11; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)	Unknown	Unknown	Unknown
YFL048C	YFL048C	EMP47	hom	Verified	1.08496374403496	0.138968856734827	no	707	0.134304583152389	512	NA	FT	VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport	ER to Golgi vesicle-mediated transport	glycoprotein binding	fungal-type vacuole membrane|integral to endoplasmic reticulum membrane|integral to Golgi membrane|ER to Golgi transport vesicle
YLR371W	YLR371W	ROM2	hom	Verified	1.08450145838364	0.139071260353771	no	708	0.250309908916983	822	NA	FF|FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING|CELL WALL ORG/BIOGENESIS|NUCLEOTIDE METABOLISM	SITE OF POLARIZED GROWTH		GDP/GTP exchange factor (GEF) for Rho1p and Rho2p; mutations are synthetically lethal with mutations in rom1, which also encodes a GEF; Rom2p localization to the bud surface is dependent on Ack1p	regulation of fungal-type cell wall organization|positive regulation of endocytosis|establishment of cell polarity|small GTPase mediated signal transduction|negative regulation of cAMP-mediated signaling|activation of Rho GTPase activity	phosphatidylinositol-4,5-bisphosphate binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity	incipient cellular bud site|mating projection tip|cellular bud tip
YBR138C_p	YBR138C	YBR138C	hom	Uncharacterized	1.08332844658145	0.139331331588926	no	709	0.102434353055475	412	NA					Cytoplasmic protein of unknown function, potentially phosphorylated by Cdc28p; YBR138C is not an essential gene	biological_process	molecular_function	cytoplasm
YCL046W_d	YCL046W	YCL046W	hom	Dubious	1.08264402933484	0.139483228126567	no	710	0.15585255892375	568	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YCL045C	Unknown	Unknown	Unknown
YNL270C	YNL270C	ALP1	hom	Verified	1.08213356044751	0.139596592639734	no	711	0.127923832596631	457	NA	FT		PLASMA MEMBRANE		Arginine transporter; expression is normally very low and it is unclear what conditions would induce significant expression; ALP1 has a paralog, CAN1, that arose from the whole genome duplication	basic amino acid transport	basic amino acid transmembrane transporter activity	integral to membrane|plasma membrane
YDR513W	YDR513W	GRX2	hom	Verified	1.08171462050562	0.139689677278369	no	712	0.122880142156437	402	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|RESPONSE TO OXIDATIVE STRESS	MITOCHONDRION		Cytoplasmic glutaredoxin; thioltransferase, glutathione-dependent disulfide oxidoreductase involved in maintaining redox state of target proteins, also exhibits glutathione peroxidase activity, expression induced in response to stress; GRX2 has a paralog, GRX1, that arose from the whole genome duplication	cellular response to oxidative stress	disulfide oxidoreductase activity|glutathione transferase activity|glutathione peroxidase activity	cytosol|mitochondrion
YDR518W	YDR518W	EUG1	hom	Verified	1.08078249058357	0.139896939437208	no	713	0.130586931079077	491	NA	FT		ENDOPLASMIC RETICULUM		Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER	protein folding	protein disulfide isomerase activity|protein disulfide oxidoreductase activity	endoplasmic reticulum
YDR010C_d	YDR010C	YDR010C	hom	Dubious	1.08008498651238	0.140052168412844	no	714	0.163664795319545	555	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YCL063W	YCL063W	VAC17	hom	Verified	1.07925730880472	0.140236519203699	no	715	0.145776922477972	551	NA					Phosphoprotein involved in vacuole inheritance; degraded in late M phase of the cell cycle; acts as a vacuole-specific receptor for myosin Myo2p	vacuole inheritance	protein anchor	fungal-type vacuole membrane
YEL049W	YEL049W	PAU2	hom	Verified	1.07874246825362	0.140351274078746	no	716	0.11089728694816	369	NA					Member of the seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme	biological_process	molecular_function	cellular_component
YLL025W	YLL025W	PAU17	hom	Verified	1.07823907414211	0.140463539250954	no	717	0.109265977806721	386	NA					Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions; YLL025W is not an essential gene	biological_process	molecular_function	cellular_component
YPL065W	YPL065W	VPS28	hom	Verified	1.07818242176923	0.140476177478229	no	718	0.164774728104792	639	NA	FF|FT	PROTEIN LOCALIZATION|PROTEOLYSIS|VACUOLAR TRANSPORT			Component of the ESCRT-I complex (Stp22p, Srn2p, Vps28p, and Mvb12p), which is involved in ubiquitin-dependent sorting of proteins into the endosome; conserved C-terminal domain interacts with ESCRT-III subunit Vps20p	protein targeting to membrane|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|protein targeting to vacuole	protein complex binding	endosome|ESCRT I complex
YML061C	YML061C	PIF1	hom	Verified	1.07727369584734	0.140679005030257	no	719	0.166995554831923	578	NA	FT	RESPONSE TO DNA DAMAGE|MITOCHONDRION ORGANIZATION	NUCLEUS|MITOCHONDRION		DNA helicase; exists in a nuclear form that acts as a catalytic inhibitor of telomerase; and as a mitochondrial form involved in repair and recombination of mitochondrial DNA; mutations affect zinc and iron homeostasis; regulated by Rad53p-dependent phosphorylation in rho0 cells	chromosome organization|negative regulation of telomere maintenance via telomerase|telomere maintenance|mitochondrial genome maintenance|DNA recombination	DNA helicase activity|telomerase inhibitor activity	mitochondrion|nucleus|mitochondrial membrane
YCR095W-A_p	YCR095W-A	YCR095W-A	hom	Uncharacterized	1.07589011133872	0.140988202478059	no	720	0.132674731128019	472	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YBR267W	YBR267W	REI1	hom	Verified	1.07422269551777	0.141361441358161	no	721	0.175112110074604	633	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RIBOSOME BIOGENESIS|CELL DIVISION		RIBOSOME	Cytoplasmic pre-60S factor; required for the correct recycling of shuttling factors Alb1, Arx1 and Tif6 at the end of the ribosomal large subunit biogenesis; involved in bud growth in the mitotic signaling network	ribosomal large subunit biogenesis|nucleocytoplasmic transport|mitotic cell cycle|budding cell bud growth	sequence-specific DNA binding	cytosolic large ribosomal subunit|preribosome, large subunit precursor|cytoplasm
YHR125W_d	YHR125W	YHR125W	hom	Dubious	1.07419206360507	0.141368304347319	no	722	0.153926985003574	602	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YCL064C	YCL064C	CHA1	hom	Verified	1.07400025733464	0.141411283107333	no	723	0.141467231994403	484	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		Catabolic L-serine (L-threonine) deaminase, catalyzes the degradation of both L-serine and L-threonine; required to use serine or threonine as the sole nitrogen source, transcriptionally induced by serine and threonine	threonine catabolic process|L-serine catabolic process	L-threonine ammonia-lyase activity|L-serine ammonia-lyase activity	mitochondrial nucleoid|mitochondrion
YOR295W	YOR295W	UAF30	hom	Verified	1.07384392214462	0.141446320277254	no	724	0.133841694881366	513	NA	FT	CHROMATIN ORGANIZATION	NUCLEUS		Subunit of UAF (upstream activation factor); UAF is an RNA polymerase I specific transcription stimulatory factor composed of Uaf30p, Rrn5p, Rrn9p, Rrn10p, histones H3 and H4; deletion decreases cellular growth rate; UAF30 has a paralog, TRI1, that arose from the whole genome duplication	transcription of nuclear large rRNA transcript from RNA polymerase I promoter|chromatin organization	RNA polymerase I upstream control element sequence-specific DNA binding|RNA polymerase I upstream control element sequence-specific DNA binding transcription factor activity	nucleolus|RNA polymerase I upstream activating factor complex
YML006C	YML006C	GIS4	hom	Verified	1.07339661150126	0.141546602108479	no	725	0.150603815897665	529	NA	FT	SIGNALING|ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		CAAX box containing protein of unknown function, proposed to be involved in the RAS/cAMP signaling pathway	cellular ion homeostasis|intracellular signal transduction	molecular_function	plasma membrane
YKL006W	YKL006W	RPL14A	hom	Verified	1.07311180629491	0.141610477209428	no	726	0.164846873544806	550	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L14A; N-terminally acetylated; homologous to mammalian ribosomal protein L14, no bacterial homolog; RPL14A has a paralog, RPL14B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome|RNA binding	cytosolic large ribosomal subunit
YJL117W	YJL117W	PHO86	hom	Verified	1.07251159064724	0.14174515537887	no	727	0.1430154879154	491	NA	FT	VESICLE-MEDIATED TRANSPORT|ION HOMEOSTASIS|ION HOMEOSTASIS	ENDOPLASMIC RETICULUM		Endoplasmic reticulum (ER) resident protein; required for ER exit of the high-affinity phosphate transporter Pho84p, specifically required for packaging of Pho84p into COPII vesicles; protein abundance increases in response to DNA replication stress	protein folding|ER to Golgi vesicle-mediated transport|regulation of phosphate transport	unfolded protein binding	endoplasmic reticulum
YPL161C	YPL161C	BEM4	hom	Verified	1.07228191648626	0.141796713290917	no	728	0.233866564291344	787	NA	FF|FT	SIGNALING|CYTOSKELETON ORGANIZATION	NUCLEUS		Protein involved in establishment of cell polarity and bud emergence; interacts with the Rho1p small GTP-binding protein and with the Rho-type GTPase Cdc42p; involved in maintenance of proper telomere length	establishment of cell polarity|Rho protein signal transduction|actin cytoskeleton organization	molecular_function	nucleus|cytoplasm
YNR051C	YNR051C	BRE5	hom	Verified	1.07129637760983	0.142018094038571	no	729	0.142330506152288	545	NA	FT	VESICLE-MEDIATED TRANSPORT			Ubiquitin protease cofactor, forms deubiquitination complex with Ubp3p that coregulates anterograde and retrograde transport between the endoplasmic reticulum and Golgi compartments; null is sensitive to brefeldin A	protein deubiquitination|ribophagy|regulation of ER to Golgi vesicle-mediated transport|Unknown	molecular_function	cytoplasm
YDR374C_p	YDR374C	YDR374C	hom	Uncharacterized	1.06914420472223	0.142502347773563	no	730	0.115846818605873	395	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YKL155C	YKL155C	RSM22	hom	Verified	1.06717654919863	0.142946060001735	no	731	0.145864951645249	507	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the small subunit; also predicted to be an S-adenosylmethionine-dependent methyltransferase	mitochondrial translation	structural constituent of ribosome|S-adenosylmethionine-dependent methyltransferase activity	mitochondrion|mitochondrial small ribosomal subunit
YMR320W_d	YMR320W	YMR320W	hom	Dubious	1.06667503244301	0.14305930268604	no	732	0.129890687478317	498	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YMR214W	YMR214W	SCJ1	hom	Verified	1.06582449325839	0.143251493302916	no	733	0.15845197745737	586	NA	FT	PROTEIN LOCALIZATION|PROTEOLYSIS	ENDOPLASMIC RETICULUM		One of several homologs of bacterial chaperone DnaJ, located in the ER lumen where it cooperates with Kar2p to mediate maturation of proteins	ER-associated protein catabolic process|protein folding in endoplasmic reticulum|response to unfolded protein	chaperone binding	endoplasmic reticulum lumen
YOR384W	YOR384W	FRE5	hom	Verified	1.06186812878322	0.144147777804571	no	734	0.164101476885719	569	NA	FT	ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION|PLASMA MEMBRANE		Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	ferric-chelate reductase activity	mitochondrion|integral to membrane
YKR092C	YKR092C	SRP40	hom	Verified	1.06171160581042	0.144183314484342	no	735	0.137818744818461	546	NA	FT		NUCLEUS		Nucleolar, serine-rich protein with a role in preribosome assembly or transport; may function as a chaperone of small nucleolar ribonucleoprotein particles (snoRNPs); immunologically and structurally to rat Nopp140	nucleocytoplasmic transport	molecular_function	nucleolus
YJL043W_p	YJL043W	YJL043W	hom	Uncharacterized	1.06110941106238	0.144320090713924	no	736	0.106579112892816	372	NA	FT		MITOCHONDRION		Putative protein of unknown function; YJL043W is a non-essential gene	biological_process	molecular_function	mitochondrion|cytoplasm
YIL160C	YIL160C	POT1	hom	Verified	1.05808701851399	0.145007886077073	no	737	0.133270141316758	430	NA	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS			3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids	fatty acid beta-oxidation	mRNA binding|acetyl-CoA C-acyltransferase activity	peroxisomal matrix|peroxisome
YHR081W	YHR081W	LRP1	hom	Verified	1.05792309311536	0.145045252987162	no	738	0.130602219309003	460	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|RNA LOCALIZATION	NUCLEUS		Nuclear exosome-associated nucleic acid binding protein; involved in RNA processing, surveillance, degradation, tethering, and export; homolog of mammalian nuclear matrix protein C1D involved in regulation of DNA repair and recombination	U5 snRNA 3'-end processing|nuclear mRNA surveillance|nuclear polyadenylation-dependent CUT catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|nuclear retention of pre-mRNA at the site of transcription|U4 snRNA 3'-end processing|polyadenylation-dependent snoRNA 3'-end processing|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	double-stranded RNA binding|double-stranded DNA binding	nuclear exosome (RNase complex)
YDR321W	YDR321W	ASP1	hom	Verified	1.05784919543342	0.145062100135084	no	739	0.141171668647974	494	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Cytosolic L-asparaginase, involved in asparagine catabolism; catalyzes hydrolysis of L-asparagine to aspartic acid and ammonia, has an important role in therapy of acute lymphoblastic leukemia; synthesized constitutively	asparagine catabolic process	asparaginase activity	intracellular
YLR380W	YLR380W	CSR1	hom	Verified	1.05684346744224	0.145291516322661	no	740	0.126517996939548	463	NA	FT	KETONE METABOLISM|LIPID METABOLISM|CELL WALL ORG/BIOGENESIS	MITOCHONDRION		Phosphatidylinositol transfer protein; has a potential role in regulating lipid and fatty acid metabolism under heme-depleted conditions; interacts specifically with thioredoxin peroxidase; may have a role in oxidative stress resistance; protein abundance increases in response to DNA replication stress	phosphatidylinositol metabolic process|Golgi to plasma membrane protein transport|Golgi to plasma membrane transport|Unknown|negative regulation of fatty acid biosynthetic process|phospholipid transport	phosphatidylinositol transporter activity|phosphatidylcholine transporter activity	cytosol|endosome|mitochondrion|lipid particle
YLR003C	YLR003C	CMS1	hom	Verified	1.05683808766033	0.145292744158438	no	741	0.118214517282501	417	NA	FT		NUCLEUS		Putative subunit of the 90S preribosome processome complex; overexpression rescues supressor mutant of mcm10; null mutant is viable; relocalizes from nucleus to cytoplasm upon DNA replication stress	biological_process	molecular_function	nucleus|90S preribosome
YLR064W	YLR064W	PER33	hom	Verified	1.05661546564355	0.145343559640244	no	742	0.136482031405626	498	NA	FT	PROTEIN LOCALIZATION|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM	NUCLEAR PORE	Protein that localizes to the endoplasmic reticulum; also associates with the nuclear pore complex; deletion extends chronological lifespan; highly conserved across species, orthologous to human TMEM33 and paralogous to Pom33p; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	integral to membrane|endoplasmic reticulum|nuclear pore
YBL080C	YBL080C	PET112	hom	Verified	1.05441979608291	0.14584538143854	no	743	0.179380989295669	620	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; mutation is functionally complemented by the bacterial GatB ortholog	glutaminyl-tRNAGln biosynthesis via transamidation|mitochondrial translation	glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity	mitochondrion|glutamyl-tRNA(Gln) amidotransferase complex
YJL078C	YJL078C	PRY3	hom	Verified	1.05280686737416	0.146214758449201	no	744	0.111991302096894	413	NA					Cell wall-associated protein involved in export of acetylated sterols; member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis related 1 proteins); role in mating efficiency; expression of full-length transcript is daughter cell-specific; in response to alpha factor, a short transcript starting at +452 is expressed and the long form is repressed by Ste12p	biological_process	molecular_function	fungal-type cell wall
YOR331C_d	YOR331C	YOR331C	hom	Dubious	1.05223543385299	0.146345773110476	no	745	0.192506987520962	633	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene VMA4/YOR332W	Unknown	Unknown	Unknown
YGR134W	YGR134W	CAF130	hom	Verified	1.05191197880112	0.146419967763549	no	746	0.131750133441908	489	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Part of the evolutionarily-conserved CCR4-NOT transcriptional regulatory complex involved in controlling mRNA initiation, elongation, and degradation	regulation of transcription from RNA polymerase II promoter|positive regulation of transcription elongation from RNA polymerase II promoter	molecular_function	CCR4-NOT core complex
YLR417W	YLR417W	VPS36	hom	Verified	1.05103051934166	0.14662228654648	no	747	0.204796305882154	735	NA	FF|FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|PROTEOLYSIS|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS			Component of the ESCRT-II complex; contains the GLUE (GRAM Like Ubiquitin binding in EAP45) domain which is involved in interactions with ESCRT-I and ubiquitin-dependent sorting of proteins into the endosome	negative regulation of transcription from RNA polymerase II promoter by glucose|protein retention in Golgi apparatus|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|protein targeting to vacuole	ubiquitin binding	ESCRT II complex
YJL124C	YJL124C	LSM1	hom	Verified	1.04934792821725	0.147009007350581	no	748	0.180004783137021	623	NA	FF|FT	RNA PROCESSING	NUCLEUS		Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) involved in degradation of cytoplasmic mRNAs; unlike most Sm-like proteins, Lsm1p requires both its SM-domain and C-terminal domain for RNA-binding; forms cytoplasmic foci upon DNA replication stress	deadenylation-dependent decapping of nuclear-transcribed mRNA|nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	RNA binding|RNA cap binding	mRNA cap binding complex|cytoplasmic mRNA processing body|cytoplasm
YLR437C	YLR437C	DIF1	hom	Verified	1.04809589674854	0.147297213302258	no	749	0.126678057507675	469	NA	FT		NUCLEUS		Protein that regulates the nuclear localization of ribonucleotide reductase Rnr2p and Rnr4p subunits; phosphorylated by Dun1p in response to DNA damage and degraded; N-terminal half has similarity to S. pombe Spd1 protein	biological_process	molecular_function	cytoplasm
YGL154C	YGL154C	LYS5	hom	Verified	1.04761130068131	0.147408864374119	no	750	0.123075332087109	420	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Phosphopantetheinyl transferase involved in lysine biosynthesis; converts inactive apo-form of Lys2p (alpha-aminoadipate reductase) into catalytically active holo-form by posttranslational addition of phosphopantetheine	lysine biosynthetic process via aminoadipic acid|protein-cofactor linkage	holo-[acyl-carrier-protein] synthase activity	cytoplasm
YIL102C_p	YIL102C	YIL102C	hom	Uncharacterized	1.04732094845671	0.147475788771143	no	751	0.134302841830672	456	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YBL094C_d	YBL094C	YBL094C	hom	Dubious	1.04682098943759	0.147591073940692	no	752	0.128662089679658	425	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized ORF YBL095W	Unknown	Unknown	Unknown
YMR196W_p	YMR196W	YMR196W	hom	Uncharacterized	1.04669250878687	0.147620709943576	no	753	0.168624171384268	586	NA	FT	CARBOHYDRATE METABOLISM			Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR196W is not an essential gene	biological_process	molecular_function	cytoplasm
YER180C-A	YER180C-A	SLO1	hom	Verified	1.04642974558555	0.147681332656406	no	754	0.165957931053301	624	NA	FT	PROTEIN LOCALIZATION			Protein interacting with Arl3p, which is a GTPase of the Ras superfamily involved in vesicle-tethering at the Golgi; putative ortholog of human SCOCO	intracellular protein transport	small GTPase regulator activity	cytoplasm
YGL191W	YGL191W	COX13	hom	Verified	1.04491125500466	0.148031993731773	no	755	0.128157213024693	487	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Subunit VIa of cytochrome c oxidase; present in a subclass of cytochrome c oxidase complexes that may have a role in mimimizing generation of reactive oxygen species; not essential for cytochrome c oxidase activity but may modulate activity in response to ATP; required for assembly of Rcf2p into cytochrome c oxidase - cytochrome bc1 supercomplexes	mitochondrial respiratory chain supercomplex assembly|aerobic respiration	enzyme regulator activity|cytochrome-c oxidase activity	mitochondrion|integral to membrane|mitochondrial respiratory chain complex IV
YCR102C_p	YCR102C	YCR102C	hom	Uncharacterized	1.04468092903321	0.148085230942563	no	756	0.148355009297911	586	NA	FT	OXIDATION-REDUCTION PROCESS			Putative protein of unknown function, involved in copper metabolism; similar to C. carbonum toxD gene; member of the quinone oxidoreductase family	response to copper ion	molecular_function	cellular_component
YGL006W-A_p	YGL006W-A	YGL006W-A	hom	Uncharacterized	1.04375379699378	0.14829965647548	no	757	0.11313908311446	422	NA					Putative protein of unknown function; identified by SAGE	biological_process	molecular_function	cellular_component
YMR103C_d	YMR103C	YMR103C	hom	Dubious	1.04223278400229	0.148651883458847	no	758	0.149769925477475	497	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YLR193C	YLR193C	UPS1	hom	Verified	1.04101233611778	0.148934911472824	no	759	0.125973863446123	451	NA	FT	LIPID METABOLISM	MITOCHONDRION		Phosphatidic acid transfer protein; plays a role in phospholipid metabolism by transporting phosphatidic acid from the outer to the inner mitochondrial membrane; localizes to the mitochondrial intermembrane space; null mutant has altered cardiolipin and phosphatidic acid levels; ortholog of human PRELI	Unknown|cardiolipin metabolic process	molecular_function	mitochondrion|extrinsic to mitochondrial inner membrane|mitochondrial intermembrane space
YDL229W	YDL229W	SSB1	hom	Verified	1.0394455608926	0.149298782008021	no	760	0.121269817553948	413	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RESPONSE TO NUTRIENT LEVELS			Cytoplasmic ATPase that is a ribosome-associated molecular chaperone; functions with J-protein partner Zuo1p; may be involved in folding of newly-made polypeptide chains; member of the HSP70 family; interacts with phosphatase subunit Reg1p; SSB1 has a paralog, SSB2, that arose from the whole genome duplication	cytoplasmic translation|cellular response to glucose starvation|translational termination|ribosomal subunit export from nucleus|regulation of translational fidelity|rRNA processing|'de novo' cotranslational protein folding	unfolded protein binding|ATPase activity|calmodulin binding	plasma membrane|polysome|cytoplasm
YPL042C	YPL042C	SSN3	hom	Verified	1.03669001084189	0.149940174437712	no	761	0.190512707870856	663	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Cyclin-dependent protein kinase, component of RNA polymerase II holoenzyme; involved in phosphorylation of the RNA polymerase II C-terminal domain; involved in glucose repression	phosphorylation of RNA polymerase II C-terminal domain|negative regulation of transcription from RNA polymerase II promoter|negative regulation of filamentous growth|protein phosphorylation|protein destabilization|nuclear-transcribed mRNA catabolic process, non-stop decay|positive regulation of transcription from RNA polymerase II promoter by galactose	RNA polymerase II carboxy-terminal domain kinase activity|protein kinase activity|cyclin-dependent protein kinase activity	mediator complex
YDR174W	YDR174W	HMO1	hom	Verified	1.03431991636174	0.150493314539064	no	762	0.152983996055257	588	NA	FT	TRANSCRIPTION FROM RNA POL II|RIBOSOME BIOGENESIS|CHROMATIN ORGANIZATION	NUCLEUS|CHROMOSOME		Chromatin associated high mobility group (HMG) family member involved in genome maintenance; rDNA-binding component of the Pol I transcription system; associates with a 5'-3' DNA helicase and Fpr1p, a prolyl isomerase	regulation of transcription from RNA polymerase I promoter|regulation of transcription by chromatin organization|regulation of ribosomal protein gene transcription from RNA polymerase II promoter	double-stranded DNA binding|four-way junction DNA binding|DNA binding, bending	nuclear chromatin|nucleolus|cytoplasm
YNL211C_p	YNL211C	YNL211C	hom	Uncharacterized	1.03376428763065	0.150623185357842	no	763	0.144580648049896	525	NA	FT		MITOCHONDRION		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL211C is not an essential gene	biological_process	molecular_function	mitochondrion
YHR195W	YHR195W	NVJ1	hom	Verified	1.03241927635523	0.150937872778904	no	764	0.164261766867229	596	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS		Nuclear envelope protein, anchored to the nuclear inner membrane, that interacts with the vacuolar membrane protein Vac8p to promote formation of nucleus-vacuole junctions during piecemeal microautophagy of the nucleus (PMN)	microautophagy|cellular protein localization	protein binding	nuclear envelope
YDR330W	YDR330W	UBX5	hom	Verified	1.03205102484197	0.151024107503041	no	765	0.120432352935712	398	NA	FT	PROTEOLYSIS	NUCLEUS		UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p	proteasomal ubiquitin-dependent protein catabolic process	molecular_function	nucleus|cytoplasm
YKL113C	YKL113C	RAD27	hom	Verified	1.03201388835925	0.151032805700532	no	766	0.185672548351486	665	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS|MITOCHONDRION		5' to 3' exonuclease, 5' flap endonuclease, required for Okazaki fragment processing and maturation as well as for long-patch base-excision repair; member of the S. pombe RAD2/FEN1 family	double-strand break repair via nonhomologous end joining|replicative cell aging|DNA replication, removal of RNA primer|base-excision repair, base-free sugar-phosphate removal|gene conversion at mating-type locus, DNA repair synthesis	5'-3' exonuclease activity|5'-flap endonuclease activity	mitochondrion|nucleus
YOR375C	YOR375C	GDH1	hom	Verified	1.03142432062041	0.151170940350628	no	767	0.143228611704888	492	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS	NUCLEUS		NADP(+)-dependent glutamate dehydrogenase; synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh3p; expression regulated by nitrogen and carbon sources; GDH1 has a paralog, GDH3, that arose from the whole genome duplication	glutamate biosynthetic process|ammonia assimilation cycle	glutamate dehydrogenase (NADP+) activity	nucleus|cytoplasm
YNL140C_p	YNL140C	YNL140C	hom	Uncharacterized	1.02986771498176	0.151536054018164	no	768	0.188894695905119	639	NA					Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps THO2/YNL139C	biological_process	molecular_function	cellular_component
YOR293W	YOR293W	RPS10A	hom	Verified	1.02854092604884	0.151847724870447	no	769	0.12764440160707	451	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10A has a paralog, RPS10B, that arose from the whole genome duplication	cytoplasmic translation|rRNA export from nucleus	structural constituent of ribosome	cytosolic small ribosomal subunit
YDR313C	YDR313C	PIB1	hom	Verified	1.02753857960771	0.152083464415752	no	770	0.149457562969129	540	NA					RING-type ubiquitin ligase of the endosomal and vacuolar membranes, binds phosphatidylinositol(3)-phosphate; contains a FYVE finger domain	protein ubiquitination	ubiquitin-protein ligase activity|phosphatidylinositol-3-phosphate binding	fungal-type vacuole membrane|late endosome
YDR220C_d	YDR220C	YDR220C	hom	Dubious	1.02596761353591	0.152453425030434	no	771	0.131496793651057	482	NA					Dubious open reading frame, null mutant exhibits synthetic phenotype with alpha-synuclein	Unknown	Unknown	Unknown
YPL162C_p	YPL162C	YPL162C	hom	Uncharacterized	1.02551214654424	0.152560798546965	no	772	0.152057941686477	534	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the membrane of vacuole with cell cycle-correlated morphology	biological_process	molecular_function	fungal-type vacuole membrane|integral to membrane
YAL009W	YAL009W	SPO7	hom	Verified	1.024029519768	0.152910666037222	no	773	0.181913971207008	678	NA	FF|FT	CELL CYCLE|LIPID METABOLISM|MEMBRANE ORGANIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM		Putative regulatory subunit of Nem1p-Spo7p phosphatase holoenzyme, regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology, premeiotic replication, and sporulation	negative regulation of phospholipid biosynthetic process|nuclear envelope organization	phosphoprotein phosphatase activity	Nem1-Spo7 phosphatase complex|integral to membrane
YOL064C	YOL064C	MET22	hom	Verified	1.0215963718008	0.153485987801796	no	774	0.179499143037131	646	NA	FT	KETONE METABOLISM|LIPID METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Bisphosphate-3'-nucleotidase, involved in salt tolerance and methionine biogenesis; dephosphorylates 3'-phosphoadenosine-5'-phosphate and 3'-phosphoadenosine-5'-phosphosulfate, intermediates of the sulfate assimilation pathway	methionine biosynthetic process|hyperosmotic salinity response|sulfate assimilation	3'(2'),5'-bisphosphate nucleotidase activity	cellular_component
YPR091C	YPR091C	NVJ2	hom	Verified	1.02152859193892	0.153502034957884	no	775	0.127455992485956	433	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Lipid-binding ER protein, enriched at nucleus-vacuolar junctions (NVJ); may be involved in sterol metabolism or signaling at the NVJ; contains a synaptotagmin-like-mitochondrial- lipid binding protein (SMP) domain; binds phosphatidylinositols and other lipids in a large-scale study; may interact with ribosomes, based on co-purification experiments	biological_process	lipid binding	ribosome|nucleus-vacuole junction|endoplasmic reticulum
YEL042W	YEL042W	GDA1	hom	Verified	1.02146536715113	0.15351700468341	no	776	0.147474661568866	519	NA	FT	CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Guanosine diphosphatase located in the Golgi, involved in the transport of GDP-mannose into the Golgi lumen by converting GDP to GMP after mannose is transferred its substrate	protein glycosylation	guanosine-diphosphatase activity|uridine-diphosphatase activity	Golgi apparatus
YGR206W	YGR206W	MVB12	hom	Verified	1.02119882450758	0.153580124583019	no	777	0.145090216416394	509	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|VACUOLAR TRANSPORT			ESCRT-I subunit required to stabilize oligomers of the ESCRT-I core complex (Stp22p, Vps28p, Srn2p), which is involved in ubiquitin-dependent sorting of proteins into the endosome; deletion mutant is sensitive to rapamycin and nystatin	negative regulation of protein complex assembly|protein targeting to vacuole|endosome transport via multivesicular body sorting pathway	ubiquitin binding	cytosol|endosome|ESCRT I complex
YNL183C	YNL183C	NPR1	hom	Verified	1.02052294856806	0.153740255631107	no	778	0.140661289106053	504	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|PROTEIN PHOSPHORYLATION	GOLGI APPARATUS|PLASMA MEMBRANE		Protein kinase that stabilizes several plasma membrane amino acid transporters by antagonizing their ubiquitin-mediated degradation; phosphorylates Aly2p; negatively regulates Ldb19p-mediated endocytosis through phosphorylation of Ldb19p, which prevents its association with the plasma membrane; Npr1p activity is negatively regulated via phosphorylation by the TOR complex	regulation of transmembrane transporter activity|regulation of nitrogen utilization|protein phosphorylation|negative regulation of endocytosis	protein serine/threonine kinase activity	Golgi apparatus|plasma membrane|cytoplasm
YDR319C_p	YDR319C	YFT2	hom	Uncharacterized	1.01951289071502	0.153979768243964	no	779	0.151316298628303	563	NA					Protein required for normal ER membrane biosynthesis; member of the highly conserved FIT family of proteins involved in triglyceride droplet biosynthesis and homologous to human FIT2; interacts with Sst2p and Hsp82p in high-throughput two-hybrid screens	biological_process	molecular_function	integral to membrane
YBR063C_p	YBR063C	YBR063C	hom	Uncharacterized	1.01572062483988	0.154881221807332	no	780	0.1389256704847	504	NA					Putative protein of unknown function; YBR063C is not an essential gene	biological_process	molecular_function	cellular_component
YMR291W	YMR291W	TDA1	hom	Verified	1.01533002017439	0.154974269444482	no	781	0.146424433349184	503	NA	FT	PROTEIN PHOSPHORYLATION	NUCLEUS		Protein kinase of unknown cellular role; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; null mutant is sensitive to expression of the top1-T722A allele; not an essential gene; relocalizes from nucleus to cytoplasm upon DNA replication stress	protein phosphorylation	protein kinase activity	nucleus|cytoplasm
YLR112W_d	YLR112W	YLR112W	hom	Dubious	1.01395848427041	0.15530128131728	no	782	0.125690336817783	429	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YNL109W_d	YNL109W	YNL109W	hom	Dubious	1.01368678448845	0.155366116021166	no	783	0.159871475336774	543	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YNL108C	Unknown	Unknown	Unknown
YOR007C	YOR007C	SGT2	hom	Verified	1.01260515310119	0.155624398745374	no	784	0.137128331647964	495	NA	FT	PROTEIN LOCALIZATION			Glutamine-rich cytoplasmic cochaperone; serves as a scaffold bringing together Get4, Get5p, and other TRC complex members that are required to mediate posttranslational insertion of tail-anchored proteins into the ER membrane; interacts with the prion domain of Sup35p; amyloid sensor; plays a role in targeting chaperones to prion aggregates; has similarity to human cochaperone SGT; forms cytoplasmic foci upon DNA replication stress	response to heat|posttranslational protein targeting to membrane	molecular_function	TRC complex|cytoplasm
YBR066C	YBR066C	NRG2	hom	Verified	1.01126502477893	0.155944800537222	no	785	0.103254366139066	377	NA	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Transcriptional repressor; mediates glucose repression and negatively regulates filamentous growth; NRG2 has a paralog, NRG1, that arose from the whole genome duplication	negative regulation of transcription from RNA polymerase II promoter by glucose|biofilm formation|pseudohyphal growth|Unknown	sequence-specific DNA binding	nucleus
YLR296W_d	YLR296W	YLR296W	hom	Dubious	1.00938918757424	0.156394010942683	no	786	0.155116115050491	549	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDR493W	YDR493W	MZM1	hom	Verified	1.00873363060224	0.156551199206049	no	787	0.14839457239479	586	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Protein required for assembly of the cytochrome bc(1) complex; acts as a chaperone for Rip1p and facilitates its insertion into the complex at a late stage of assembly; localized to the mitochondrial matrix; null mutant exhibits a respiratory growth defect and reduced mitochondrial zinc levels, which is characteristic of mutations affecting bc(1) complex assembly; human LYRM7 is a functional ortholog	mitochondrial respiratory chain complex III assembly	molecular_function	mitochondrion|mitochondrial matrix
YPL194W	YPL194W	DDC1	hom	Verified	1.00861164646185	0.156580459816561	no	788	0.143014624092202	484	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		DNA damage checkpoint protein; part of a PCNA-like complex required for DNA damage response, required for pachytene checkpoint to inhibit cell cycle in response to unrepaired recombination intermediates; potential Cdc28p substrate; forms nuclear foci upon DNA replication stress	meiosis|mitotic cell cycle G1/S transition checkpoint|intra-S DNA damage checkpoint|recombinational repair|G2/M transition checkpoint|cell cycle checkpoint	molecular_function	condensed nuclear chromosome|checkpoint clamp complex
YLR289W	YLR289W	GUF1	hom	Verified	1.00852477045894	0.156601301154168	no	789	0.169763777695119	583	NA	FT	TRANSLATION|NUCLEOTIDE METABOLISM	MITOCHONDRION	RIBOSOME	Mitochondrial matrix GTPase that associates with mitochondrial ribosomes; important for translation under temperature and nutrient stress; may have a role in translational fidelity; similar to bacterial LepA elongation factor	positive regulation of translation	ribosome binding|GTPase activity	mitochondrion|mitochondrial ribosome|mitochondrial matrix
YGR102C	YGR102C	GTF1	hom	Verified	1.00803957924286	0.156717730901985	no	790	0.158158709527943	565	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION	MITOCHONDRION		Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is salt sensitive and null mutant has growth defects; non-tagged protein is detected in purified mitochondria	glutaminyl-tRNAGln biosynthesis via transamidation	glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity	mitochondrion|glutamyl-tRNA(Gln) amidotransferase complex
YDR071C	YDR071C	PAA1	hom	Verified	1.00771351603861	0.156796007222701	no	791	0.16783410741761	599	NA	FT	CHROMATIN ORGANIZATION			Polyamine acetyltransferase; acetylates polyamines (e.g. putrescine, spermidine, spermine) and also aralkylamines (e.g. tryptamine, phenylethylamine); may be involved in transcription and/or DNA replication	chromatin organization	diamine N-acetyltransferase activity|aralkylamine N-acetyltransferase activity	cytoplasm
YOR367W	YOR367W	SCP1	hom	Verified	1.00717208068059	0.156926043654337	no	792	0.176268434218883	622	NA	FT	CYTOSKELETON ORGANIZATION	CYTOSKELETON		Component of yeast cortical actin cytoskeleton, binds and cross links actin filaments; originally identified by its homology to calponin (contains a calponin-like repeat) but the Scp1p domain structure is more similar to transgelin	actin filament organization|chronological cell aging	actin filament binding|protein binding, bridging	actin cortical patch
YDR204W	YDR204W	COQ4	hom	Verified	1.00649359078303	0.157089096585197	no	793	0.143819226097821	533	NA	FT	KETONE METABOLISM|COFACTOR METABOLISM	MITOCHONDRION		Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex	ubiquinone biosynthetic process	molecular_function	mitochondrial inner membrane
YDR006C	YDR006C	SOK1	hom	Verified	1.00341411061672	0.157830549332891	no	794	0.142835675583089	464	NA	FT	SIGNALING	NUCLEUS		Protein whose overexpression suppresses the growth defect of mutants lacking protein kinase A activity; involved in cAMP-mediated signaling; localized to the nucleus; similar to the mouse testis-specific protein PBS13	cAMP-mediated signaling	molecular_function	nucleus
YJR097W	YJR097W	JJJ3	hom	Verified	1.00250695161728	0.158049405401075	no	795	0.168394717332768	588	NA	FT		NUCLEUS		Protein of unknown function, contains a CSL Zn finger and a DnaJ-domain; involved in diphthamide biosynthesis; ortholog human Dph4	peptidyl-diphthamide biosynthetic process from peptidyl-histidine	ferrous iron binding	nucleus|cytoplasm
YAL015C	YAL015C	NTG1	hom	Verified	1.00198475995243	0.158175476721716	no	796	0.142156147436028	487	NA	FT	RESPONSE TO DNA DAMAGE|MITOCHONDRION ORGANIZATION|RESPONSE TO OXIDATIVE STRESS	NUCLEUS|MITOCHONDRION		DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; NTG1 has a paralog, NTG2, that arose from the whole genome duplication	DNA repair|cellular response to oxidative stress|base-excision repair|base-excision repair, AP site formation|positive regulation of mitochondrial DNA replication	oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity|oxidized purine nucleobase lesion DNA N-glycosylase activity|DNA-(apurinic or apyrimidinic site) lyase activity	mitochondrion|nucleus
YDR524W-C_p	YDR524W-C	YDR524W-C	hom	Uncharacterized	1.00187609059284	0.1582017207653	no	797	0.176180245811326	630	NA					Putative protein of unknown function; small ORF identified by SAGE; deletion strains are moderately sensitive to the radiomimetic drug bleomycin	biological_process	molecular_function	cellular_component
YGR020C	YGR020C	VMA7	hom	Verified	1.00145340916312	0.158303827032405	no	798	0.211335304554651	744	NA	FF|FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Subunit F of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane	vacuolar acidification	proton-transporting ATPase activity, rotational mechanism	fungal-type vacuole membrane|vacuolar proton-transporting V-type ATPase, V1 domain|integral to membrane
YDR159W	YDR159W	SAC3	hom	Verified	1.00132751563396	0.158334247223867	no	799	0.228891195284668	821	NA	FF|FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|RIBOSOME BIOGENESIS|RESPONSE TO DNA DAMAGE|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	Nuclear pore-associated protein; required for biogenesis of the small ribosomal subunit; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; similar to the human germinal center-associated nuclear protein (GANP)	ribosomal small subunit biogenesis|actin filament-based process|mRNA export from nucleus|mRNA 3'-end processing|mitosis|protein export from nucleus|transcription-coupled nucleotide-excision repair|nuclear retention of pre-mRNA at the site of transcription|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery	protein binding	transcription export complex 2|nuclear pore
YMR206W_p	YMR206W	YMR206W	hom	Uncharacterized	0.997327445707423	0.159302797972489	no	800	0.142883643893532	500	NA					Putative protein of unknown function; not an essential gene; YMR206W has a paralog, YNR014W, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YMR156C	YMR156C	TPP1	hom	Verified	0.996894591301181	0.159407838652348	no	801	0.157565943956974	570	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		DNA 3'-phosphatase; functions in repair of endogenous damage of double-stranded DNA, activity is specific for removal of 3' phosphates at strand breaks; similar to the l-2-haloacid dehalogenase superfamily; homolog of human polynucleotide kinase/3&#8242;-phosphatase	DNA repair	polynucleotide 3'-phosphatase activity	cellular_component
YLR286C	YLR286C	CTS1	hom	Verified	0.996282459844666	0.159556461842805	no	802	0.150386347329106	557	NA	FT	CELL WALL ORG/BIOGENESIS|CELL DIVISION|CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|SITE OF POLARIZED GROWTH		Endochitinase, required for cell separation after mitosis; transcriptional activation during the G1 phase of the cell cycle is mediated by transcription factor Ace2p	cytokinesis, completion of separation|chitin catabolic process	endochitinase activity	nuclear envelope|extracellular region|fungal-type cell wall|endoplasmic reticulum|cellular bud neck
YPL189W	YPL189W	GUP2	hom	Verified	0.99405269250997	0.160098607517189	no	803	0.109456421907446	384	NA					Probable membrane protein with a possible role in proton symport of glycerol; member of the MBOAT family of putative membrane-bound O-acyltransferases; Gup1p homolog	glycerol transport	O-acyltransferase activity	integral to membrane|membrane
YHR106W	YHR106W	TRR2	hom	Verified	0.99380764478708	0.160158261794667	no	804	0.12805766259362	452	NA	FT	OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS	MITOCHONDRION		Mitochondrial thioredoxin reductase; involved in protection against oxidative stress, required with Glr1p to maintain the redox state of Trx3p; contains active-site motif (CAVC) present in prokaryotic orthologs; binds NADPH and FAD; TRR2 has a paralog, TRR1, that arose from the whole genome duplication	cellular response to oxidative stress|cell redox homeostasis	thioredoxin-disulfide reductase activity	mitochondrion
YOR086C	YOR086C	TCB1	hom	Verified	0.99354444157009	0.160222352019228	no	805	0.135217090876088	475	NA	FT		ENDOPLASMIC RETICULUM|MITOCHONDRION|PLASMA MEMBRANE		Lipid-binding ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; contains three calcium and lipid binding domains; non-tagged protein also localizes to mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact	biological_process	lipid binding	mitochondrion|plasma membrane|cortical endoplasmic reticulum
YLR426W_p	YLR426W	TDA5	hom	Uncharacterized	0.992798435842872	0.160404096180447	no	806	0.214812064228223	740	NA	FT	OXIDATION-REDUCTION PROCESS	MITOCHONDRION		Putative protein of unknown function; detected in highly purified mitochondria in high-throughput studies; proposed to be involved in resistance to mechlorethamine and streptozotocin; null mutant sensitive to expression of top1-T722A allele	response to drug	molecular_function	mitochondrion|integral to membrane
YIR003W	YIR003W	AIM21	hom	Verified	0.992118331347731	0.160569902623214	no	807	0.140558669402522	495	NA	FT		SITE OF POLARIZED GROWTH|CYTOSKELETON		Protein of unknown function involved in mitochondrial migration along actin filament; may interact with ribosomes; GFP-fusion protein colocalizes with Sac1p to the actin cytoskeleton	mitochondrion migration along actin filament	molecular_function	ribosome|mating projection tip|actin cytoskeleton
YPL254W	YPL254W	HFI1	hom	Verified	0.991716722793095	0.160667865553622	no	808	0.178515668059342	621	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION	NUCLEUS	HISTONE ACETYLTRANSFERASE	Adaptor protein required for structural integrity of the SAGA complex, a histone acetyltransferase-coactivator complex that is involved in global regulation of gene expression through acetylation and transcription functions	histone acetylation|chromatin modification|transcription from RNA polymerase II promoter	transcription coactivator activity|transcription cofactor activity	SLIK (SAGA-like) complex|Ada2/Gcn5/Ada3 transcription activator complex|SAGA complex
YLR390W	YLR390W	ECM19	hom	Verified	0.991397756489047	0.16074569766232	no	809	0.189997947777332	667	NA	FT	CELL WALL ORG/BIOGENESIS	MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	fungal-type cell wall organization	molecular_function	mitochondrion
YBL029C-A	YBL029C-A	YBL029C-A	hom	Verified	0.989762807557076	0.161145033861163	no	810	0.16330654558385	532	NA	FT		PLASMA MEMBRANE		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; protein abundance increases in response to DNA replication stress; has potential orthologs in Saccharomyces species and in Yarrowia lipolytica	biological_process	molecular_function	plasma membrane
YER176W	YER176W	ECM32	hom	Verified	0.989336390645319	0.161249292507517	no	811	0.145015142005149	526	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION			DNA dependent ATPase/DNA helicase belonging to the Dna2p- and Nam7p-like family of helicases that is involved in modulating translation termination; interacts with the translation termination factors, localized to polysomes	regulation of translational termination	RNA helicase activity|DNA helicase activity	polysome
YDR320C	YDR320C	SWA2	hom	Verified	0.988920471583857	0.161351026818188	no	812	0.223323252544937	727	NA	FF|FT	VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|NUCLEOTIDE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Auxilin-like protein involved in vesicular transport; clathrin-binding protein required for uncoating of clathrin-coated vesicles	positive regulation of ATPase activity|endoplasmic reticulum inheritance|clathrin coat disassembly	ubiquitin binding|clathrin binding	endoplasmic reticulum membrane
YER156C_p	YER156C	YER156C	hom	Uncharacterized	0.985909922455456	0.162088658664935	no	813	0.145213941910402	518	NA	FT		NUCLEUS		Putative protein of unknown function; interacts with Hsp82p and copurifies with Ipl1p; expression is copper responsive and downregulated in strains deleted for MAC1, a copper-responsive transcription factor; similarity to mammalian MYG1	biological_process	molecular_function	nucleus|cytoplasm
YKL167C	YKL167C	MRP49	hom	Verified	0.985104199299168	0.162286445446059	no	814	0.169371646863716	554	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit, not essential for mitochondrial translation	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YHL036W	YHL036W	MUP3	hom	Verified	0.984810162402088	0.162358663957369	no	815	0.173288014787414	610	NA					Low affinity methionine permease, similar to Mup1p	amino acid transport	L-methionine transmembrane transporter activity	integral to membrane|membrane
YCR011C	YCR011C	ADP1	hom	Verified	0.984632830451731	0.162402228634127	no	816	0.143573053764864	532	NA	FT	NUCLEOTIDE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Putative ATP-dependent permease of the ABC transporter family of proteins	transport|transmembrane transport	ATPase activity, coupled to transmembrane movement of substances	integral to membrane|endoplasmic reticulum|cytoplasm
YCL049C_p	YCL049C	YCL049C	hom	Uncharacterized	0.984567570238622	0.162418262855055	no	817	0.161825318076013	578	NA					Protein of unknown function; localizes to membrane fraction; YCL049C is not an essential gene	biological_process	molecular_function	membrane
YMR190C	YMR190C	SGS1	hom	Verified	0.984479014102713	0.162440022455618	no	818	0.152944744232383	548	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME		Nucleolar DNA helicase of the RecQ family; involved in genome integrity maintenance; regulates chromosome synapsis and meiotic joint molecule/crossover formation; potential role as repressor of a subset of rapamycin responsive genes; rapidly lost in response to rapamycin in Rrd1p-dependent manner; similar to human BLM and WRN proteins implicated in Bloom and Werner syndromes; forms nuclear foci upon DNA replication stress	DNA double-strand break processing|meiotic DNA double-strand break processing|telomeric 3' overhang formation|meiotic chromosome segregation|DNA unwinding involved in replication|double-strand break repair via homologous recombination|intra-S DNA damage checkpoint|telomere maintenance via recombination|replicative cell aging|DNA duplex unwinding|response to DNA damage stimulus|negative regulation of meiotic joint molecule formation|chromosome organization|regulation of reciprocal meiotic recombination|gene conversion at mating-type locus, DNA double-strand break processing|mitotic sister chromatid segregation	ATP-dependent DNA helicase activity	RecQ helicase-Topo III complex|nucleolus
YDL006W	YDL006W	PTC1	hom	Verified	0.984296995440118	0.162484753189236	no	819	0.236561930041943	845	NA	FF|FT	RNA PROCESSING|SIGNALING|MITOCHONDRION ORGANIZATION|PROTEIN PHOSPHORYLATION	NUCLEUS		Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p, inactivating osmosensing MAPK cascade; involved in Fus3p activation during pheromone response; deletion affects precursor tRNA splicing, mitochondrial inheritance, and sporulation	mitochondrion inheritance|inactivation of MAPK activity involved in osmosensory signaling pathway|pheromone-dependent signal transduction involved in conjugation with cellular fusion|tRNA splicing, via endonucleolytic cleavage and ligation|protein dephosphorylation	protein serine/threonine phosphatase activity	nucleus|cytoplasm
YGL221C	YGL221C	NIF3	hom	Verified	0.984150463349754	0.162520768989678	no	820	0.15286645129835	528	NA	FT		MITOCHONDRION		Protein of unknown function, similar to Listeria monocytogenes major sigma factor (rpoD gene product); the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion|cytoplasm
YOR078W	YOR078W	BUD21	hom	Verified	0.983751894976622	0.162618758512684	no	821	0.157587955022827	539	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Component of small ribosomal subunit (SSU) processosome that contains U3 snoRNA; originally isolated as bud-site selection mutant that displays a random budding pattern	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	snoRNA binding	small-subunit processome|nucleolus|90S preribosome
YLR232W_d	YLR232W	YLR232W	hom	Dubious	0.981915793451237	0.163070667202638	no	822	0.145641967382543	483	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene BNA5	Unknown	Unknown	Unknown
YPR173C	YPR173C	VPS4	hom	Verified	0.981469944931088	0.163180524285595	no	823	0.199296598747395	686	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|LIPID METABOLISM|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT	ENDOPLASMIC RETICULUM		AAA-ATPase involved in multivesicular body (MVB) protein sorting, ATP-bound Vps4p localizes to endosomes and catalyzes ESCRT-III disassembly and membrane release; ATPase activity is activated by Vta1p; regulates cellular sterol metabolism	late endosome to vacuole transport via multivesicular body sorting pathway|protein retention in Golgi apparatus|intralumenal vesicle formation|protein homooligomerization|sterol metabolic process|late endosome to vacuole transport	ATPase activity|protein homodimerization activity|ATP binding	endosome|endoplasmic reticulum|membrane|cytoplasm
YDR026C	YDR026C	NSI1	hom	Verified	0.97425624350361	0.164964662400873	no	824	0.136893058429898	444	NA	FT	CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS|CHROMOSOME		RNA polymerase I termination factor; binds to rDNA terminator element, required for efficient Pol I termination; required for rDNA silencing at NTS1; facilities association of Sir2p with NTS1, contributes to rDNA stability and cell longevity; interacts physically with Fob1p and RENT subunits, Sir2p and Net1p; may interact with ribosomes, based on co-purification experiments; Myb-like DNA-binding protein; NSI1 has a paralog, REB1, that arose from the whole genome duplication	termination of RNA polymerase I transcription|chromatin silencing at rDNA|Unknown	DNA binding	ribosome|nucleolus|rDNA heterochromatin
YGR028W	YGR028W	MSP1	hom	Verified	0.974052926933346	0.165015130281792	no	825	0.146069241002805	473	NA	FT	PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial protein involved in sorting of proteins in the mitochondria; putative membrane-spanning ATPase	protein targeting to mitochondrion	ATPase activity	mitochondrial outer membrane|mitochondrion
YGL248W	YGL248W	PDE1	hom	Verified	0.973659194656446	0.165112892172053	no	826	0.150273562596127	517	NA	FT	SIGNALING|NUCLEOTIDE METABOLISM			Low-affinity cyclic AMP phosphodiesterase, controls glucose and intracellular acidification-induced cAMP signaling, target of the cAMP-protein kinase A (PKA) pathway; glucose induces transcription and inhibits translation	cAMP-mediated signaling	3',5'-cyclic-AMP phosphodiesterase activity	cellular_component
YGR268C	YGR268C	HUA1	hom	Verified	0.972821674506308	0.165320969195622	no	827	0.18230763869324	637	NA					Cytoplasmic protein containing a zinc finger domain with sequence similarity to that of Type I J-proteins; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin patch assembly	biological_process	molecular_function	cytoplasm
YPL277C_p	YPL277C	YPL277C	hom	Uncharacterized	0.972695435470213	0.165352347260725	no	828	0.148110677122015	528	NA					Putative protein of unknown function; localized to the membranes; gene expression regulated by copper levels	biological_process	molecular_function	membrane
YHR026W	YHR026W	VMA16	hom	Verified	0.971662243912455	0.16560930291188	no	829	0.269602038028027	897	NA	FF|FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Subunit c'' of the vacuolar ATPase, which functions in acidification of the vacuole; one of three proteolipid subunits of the V0 domain	vacuolar acidification	proton-transporting ATPase activity, rotational mechanism	vacuolar proton-transporting V-type ATPase, V0 domain|integral to membrane
YBR101C	YBR101C	FES1	hom	Verified	0.965008947834018	0.167270165039412	no	830	0.165847291206489	602	NA	FT	TRANSLATION		RIBOSOME	Hsp70 (Ssa1p) nucleotide exchange factor; cytosolic homolog of Sil1p, which is the nucleotide exchange factor for BiP (Kar2p) in the endoplasmic reticulum; protein abundance increases in response to DNA replication stress	cytoplasmic translation	adenyl-nucleotide exchange factor activity	cytosol|cytosolic ribosome
YNL177C	YNL177C	MRPL22	hom	Verified	0.962295934879007	0.167950485204821	no	831	0.203654600904105	693	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YIR021W	YIR021W	MRS1	hom	Verified	0.961222700445292	0.168220102404427	no	832	0.140955554236106	516	NA	FT	RNA PROCESSING	MITOCHONDRION		Protein required for the splicing of two mitochondrial group I introns (BI3 in COB and AI5beta in COX1); forms a splicing complex, containing four subunits of Mrs1p and two subunits of the BI3-encoded maturase, that binds to the BI3 RNA	Group I intron splicing	endodeoxyribonuclease activity|RNA binding	mitochondrion
YOR285W	YOR285W	RDL1	hom	Verified	0.960718530089525	0.168346855798869	no	833	0.155027350322054	540	NA	FT		ENDOPLASMIC RETICULUM|MITOCHONDRION		Protein of unknown function containing a rhodanese-like domain; localized to the mitochondrial outer membrane; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	mitochondrial outer membrane|mitochondrion|endoplasmic reticulum
YER039C	YER039C	HVG1	hom	Verified	0.960294570970429	0.168453490830296	no	834	0.170499633105431	588	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Protein of unknown function, has homology to Vrg4p	biological_process	molecular_function	integral to membrane
YDR507C	YDR507C	GIN4	hom	Verified	0.958405681495841	0.168929115711278	no	835	0.175193573799751	649	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION	SITE OF POLARIZED GROWTH		Protein kinase involved in bud growth and assembly of the septin ring; proposed to have kinase-dependent and kinase-independent activities; undergoes autophosphorylation; similar to Hsl1p; GIN4 has a paralog, KCC4, that arose from the whole genome duplication	protein autophosphorylation|budding cell bud growth|protein phosphorylation|septin checkpoint|septin ring assembly	protein kinase activity	cellular bud neck
YFR041C	YFR041C	ERJ5	hom	Verified	0.95793029056351	0.169048955529422	no	836	0.153962722651729	577	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Type I membrane protein with a J domain is required to preserve the folding capacity of the endoplasmic reticulum; loss of the non-essential ERJ5 gene leads to a constitutively induced unfolded protein response	protein folding	molecular_function	endoplasmic reticulum
YML075C	YML075C	HMG1	hom	Verified	0.956731673379795	0.169351353514652	no	837	0.168382125614241	602	NA	FT	LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM		HMG-CoA reductase; catalyzes the conversion of HMG-CoA to mevalonate, which is a rate-limiting step in sterol biosynthesis; one of two isozymes; localizes to the nuclear envelope; overproduction induces the formation of karmellae; forms foci at the nuclear periphery upon DNA replication stress	ergosterol biosynthetic process|isopentenyl diphosphate biosynthetic process, mevalonate pathway	hydroxymethylglutaryl-CoA reductase (NADPH) activity	nuclear envelope|integral to membrane|endoplasmic reticulum membrane
YLR374C_d	YLR374C	YLR374C	hom	Dubious	0.95579226710983	0.169588597962188	no	838	0.225699091861978	771	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF STP3/YLR375W	Unknown	Unknown	Unknown
YHL019C	YHL019C	APM2	hom	Verified	0.95536177991315	0.169697387516869	no	839	0.158968238483313	586	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Protein of unknown function, homologous to the medium chain of mammalian clathrin-associated protein complex; involved in vesicular transport	Golgi to vacuole transport|vesicle-mediated transport	clathrin binding	AP-1 adaptor complex
YOR084W	YOR084W	LPX1	hom	Verified	0.955163255720113	0.169747572166699	no	840	0.132142750248947	428	NA	FT	PEROXISOME ORGANIZATION			Oleic acid-inducible, peroxisomal matrix localized lipase; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance; peroxisomal import is dependent on the PTS1 receptor, Pex5p and on self-interaction	peroxisome organization	lipase activity	peroxisomal matrix
YHR001W	YHR001W	OSH7	hom	Verified	0.953821335136883	0.17008704394862	no	841	0.142474838882122	473	NA	FT	VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT	ENDOPLASMIC RETICULUM		Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability	maintenance of cell polarity|endocytosis|exocytosis|sterol transport|sterol metabolic process|late endosome to vacuole transport	lipid binding|oxysterol binding	integral to membrane|cortical endoplasmic reticulum|cytoplasm
YPR012W_d	YPR012W	YPR012W	hom	Dubious	0.953225315073027	0.170237961312868	no	842	0.164113730633952	583	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPR012W is not an essential gene	Unknown	Unknown	Unknown
YPL170W	YPL170W	DAP1	hom	Verified	0.951271737187283	0.170733225141521	no	843	0.1977465612712	704	NA	FT	LIPID METABOLISM			Heme-binding protein involved in regulation of cytochrome P450 protein Erg11p; damage response protein, related to mammalian membrane progesterone receptors; mutations lead to defects in telomeres, mitochondria, and sterol synthesis	regulation of ergosterol biosynthetic process	heme binding	endosome|membrane
YDR432W	YDR432W	NPL3	hom	Verified	0.951102579887894	0.170776152614169	no	844	0.201400252397315	716	NA	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION	NUCLEUS		RNA-binding protein; promotes elongation, regulates termination, and carries poly(A) mRNA from nucleus to cytoplasm; has a role in repressing translation initiation by binding eIF4G; required for pre-mRNA splicing; dissociation from mRNAs promoted by Mtr10p; phosphorylated by Sky1p in the cytoplasm; protein abundance increases in response to DNA replication stress	translational termination|mRNA export from nucleus|negative regulation of translation|mRNA splicing, via spliceosome|Unknown|positive regulation of transcription elongation from RNA polymerase II promoter	mRNA binding|RNA polymerase II core binding|eukaryotic initiation factor 4G binding|poly(A) RNA binding	nucleus|cytoplasm
YJR005W	YJR005W	APL1	hom	Verified	0.950442559771328	0.170943713626805	no	845	0.169902016264191	600	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|PLASMA MEMBRANE		Beta-adaptin, large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport; similar to mammalian beta-chain of the clathrin associated protein complex	vesicle-mediated transport	molecular_function	AP-2 adaptor complex
YEL063C	YEL063C	CAN1	hom	Verified	0.949918444422139	0.171076847044308	no	846	0.188534141544601	674	NA	FT		MITOCHONDRION|PLASMA MEMBRANE		Plasma membrane arginine permease; requires phosphatidyl ethanolamine (PE) for localization, exclusively associated with lipid rafts; mutation confers canavanine resistance; CAN1 has a paralog, ALP1, that arose from the whole genome duplication	basic amino acid transport|transmembrane transport	basic amino acid transmembrane transporter activity|arginine transmembrane transporter activity	mitochondrion|integral to membrane|membrane raft|plasma membrane
YMR312W	YMR312W	ELP6	hom	Verified	0.948697383468685	0.171387272593887	no	847	0.180463561558954	608	NA	FT	TRANSCRIPTION FROM RNA POL II|RNA PROCESSING	NUCLEUS		Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity	protein urmylation|regulation of transcription from RNA polymerase II promoter|tRNA wobble uridine modification	ATPase activity|tRNA binding	Elongator holoenzyme complex
YBR171W	YBR171W	SEC66	hom	Verified	0.942465593570924	0.172977159227864	no	848	0.289737705967233	1011	NA	FF|FT	PROTEIN LOCALIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER	posttranslational protein targeting to membrane, translocation|filamentous growth	protein transporter activity	integral to membrane|Sec62/Sec63 complex|endoplasmic reticulum membrane
YNL197C	YNL197C	WHI3	hom	Verified	0.94061201033987	0.173451862405318	no	849	0.177391330692165	656	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE			RNA binding protein that sequesters CLN3 mRNA in cytoplasmic foci;; Tpk1 (PKA) mediated phosphorylation of Whi3 affects G1/S transition by modulating Cln3 transcription; cytoplasmic retention factor for Cdc28p and associated cyclins; regulates cell fate and dose-dependently regulates the critical cell size required for passage through Start; WHI3 has a paralog, WHI4, that arose from the whole genome duplication	pseudohyphal growth|invasive growth in response to glucose limitation|regulation of cell size|cytoplasmic sequestering of protein	RNA binding	cytoplasm
YPR111W	YPR111W	DBF20	hom	Verified	0.939720061613716	0.173680585945101	no	850	0.144276692368989	523	NA	FT	CELL CYCLE|CELL DIVISION|PROTEIN PHOSPHORYLATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Ser/Thr kinase involved in late nuclear division, one of the mitotic exit network (MEN) proteins; necessary for the execution of cytokinesis; also plays a role in regulating the stability of SWI5 and CLB2 mRNAs	cytokinesis after mitosis|protein phosphorylation|barrier septum assembly involved in cell cycle cytokinesis|regulation of mRNA catabolic process|exit from mitosis	protein serine/threonine kinase activity	spindle pole body|cellular bud neck|cytoplasm
YHR012W	YHR012W	VPS29	hom	Verified	0.937961993420932	0.174131971147159	no	851	0.195568731530829	699	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM		Endosomal protein that is a subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde transport; forms a subcomplex with Vps35p and Vps26p that selects cargo proteins for endosome-to-Golgi retrieval	retrograde transport, endosome to Golgi	protein transporter activity	endosome|retromer complex, inner shell|retromer complex
YLR264C-A_p	YLR264C-A	YLR264C-A	hom	Uncharacterized	0.936849660318933	0.174417948207936	no	852	0.174980641569938	613	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YJL036W	YJL036W	SNX4	hom	Verified	0.936533523469767	0.174499280333261	no	853	0.214097518810652	744	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT			Sorting nexin, involved in retrieval of late-Golgi SNAREs from post-Golgi endosomes to the trans-Golgi network and in cytoplasm to vacuole transport; contains a PX phosphoinositide-binding domain; forms complexes with Snx41p and with Atg20p	piecemeal microautophagy of nucleus|mitochondrion degradation|early endosome to Golgi transport|CVT pathway|protein targeting to vacuole	phosphatidylinositol-3-phosphate binding	cytosol|pre-autophagosomal structure|extrinsic to membrane|early endosome
YDR079W	YDR079W	PET100	hom	Verified	0.935911111416204	0.174659477875054	no	854	0.181275345635101	636	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Chaperone that specifically facilitates the assembly of cytochrome c oxidase, integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme	mitochondrial respiratory chain complex IV assembly|aerobic respiration	unfolded protein binding	mitochondrion|mitochondrial inner membrane|integral to mitochondrial inner membrane
YDR116C	YDR116C	MRPL1	hom	Verified	0.934940466848696	0.174909490423853	no	855	0.166390867100096	582	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YGR258C	YGR258C	RAD2	hom	Verified	0.934739350174738	0.174961321186497	no	856	0.140221509012899	477	NA	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO DNA DAMAGE	NUCLEUS		Single-stranded DNA endonuclease, cleaves single-stranded DNA during nucleotide excision repair to excise damaged DNA; subunit of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPG protein	nucleotide-excision repair, DNA incision, 3'-to lesion|transcription from RNA polymerase II promoter	single-stranded DNA specific endodeoxyribonuclease activity	nucleotide-excision repair factor 3 complex
YOR124C	YOR124C	UBP2	hom	Verified	0.934465802747592	0.175031834073922	no	857	0.167204504652549	593	NA	FT	PROTEOLYSIS			Ubiquitin-specific protease that removes ubiquitin from ubiquitinated proteins; interacts with Rsp5p and is required for MVB sorting of membrane proteins; can cleave polyubiquitin and has isopeptidase activity	protein deubiquitination|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	ubiquitin-specific protease activity	cytoplasm
YGR164W_d	YGR164W	YGR164W	hom	Dubious	0.934412792598022	0.175045500695281	no	858	0.173740692820235	650	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YCR063W	YCR063W	BUD31	hom	Verified	0.934074590752065	0.175132708926668	no	859	0.151764041187472	560	NA	FT	CELL CYCLE|RNA PROCESSING|CELL DIVISION	NUCLEUS		Component of the SF3b subcomplex of the U2 snRNP; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; facilitates passage through G1/S Start, but is not required for G2/M transition or exit from mitosis	RNA splicing|mRNA splicing, via spliceosome|cellular bud site selection	molecular_function	U2 snRNP|nucleus
YOR072W_d	YOR072W	YOR072W	hom	Dubious	0.933517004520937	0.175276547454418	no	860	0.240718727123053	861	NA	FF				Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOR072W-A; diploid deletion strains are methotrexate, paraquat and wortmannin sensitive	Unknown	Unknown	Unknown
YLL033W	YLL033W	IRC19	hom	Verified	0.933189248934136	0.175361132341	no	861	0.153864395376222	536	NA					Putative protein of unknown function; YLL033W is not an essential gene but mutant is defective in spore formation; null mutant displays increased levels of spontaneous Rad52p foci	mitotic recombination|ascospore formation	molecular_function	cellular_component
YPL078C	YPL078C	ATP4	hom	Verified	0.933071262042926	0.17539158791272	no	862	0.176549809126913	613	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS	MITOCHONDRION		Subunit b of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; contributes to the oligomerization of the complex; phosphorylated	protein complex oligomerization|ATP synthesis coupled proton transport	proton-transporting ATPase activity, rotational mechanism	mitochondrion|mitochondrial proton-transporting ATP synthase, stator stalk|integral to membrane
YOL145C	YOL145C	CTR9	hom	Verified	0.93207664772436	0.175648457731088	no	863	0.224281410741606	795	NA	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION|GENE SILENCING	NUCLEUS|CHROMOSOME	RNA POL II, HOLOENZYME	Component of the Paf1p complex involved in transcription elongation; binds to and modulates the activity of RNA polymerases I and II; required for expression of a subset of genes, including cyclin genes; involved in SER3 repression by helping to maintain SRG1 transcription-dependent nucleosome occupancy; contains TPR repeats	transcription elongation from RNA polymerase I promoter|mRNA 3'-end processing|regulation of chromatin silencing at telomere|snoRNA transcription from an RNA polymerase II promoter|regulation of transcription by chromatin organization|transcription from RNA polymerase I promoter|regulation of histone H3-K4 methylation|regulation of transcription-coupled nucleotide-excision repair|regulation of transcription initiation from RNA polymerase II promoter|snoRNA 3'-end processing|Unknown|regulation of transcription involved in G1 phase of mitotic cell cycle|transcription elongation from RNA polymerase II promoter	RNA polymerase II core binding|triplex DNA binding|RNA polymerase II transcription factor binding transcription factor activity	transcriptionally active chromatin|nucleus|Cdc73/Paf1 complex
YKL032C	YKL032C	IXR1	hom	Verified	0.930976961938334	0.17593274070667	no	864	0.21406505195468	738	NA	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Protein that binds DNA containing intrastrand cross-links formed by cisplatin, contains two HMG (high mobility group box) domains, which confer the ability to bend cisplatin-modified DNA; mediates aerobic transcriptional repression of COX5b	DNA repair|cellular response to hypoxia|negative regulation of transcription from RNA polymerase II promoter	damaged DNA binding|sequence-specific DNA binding	nuclear chromatin
YBL059W_p	YBL059W	YBL059W	hom	Uncharacterized	0.930811704828209	0.175975486972431	no	865	0.193889436862895	653	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YBL059W has a paralog, YER093C-A, that arose from the whole genome duplication	biological_process	molecular_function	mitochondrion
YLR327C	YLR327C	TMA10	hom	Verified	0.928308470060612	0.176623790850938	no	866	0.176959178679415	619	NA	FT		NUCLEUS|MITOCHONDRION		Protein of unknown function that associates with ribosomes; putative homolog of the F1F0-ATPase synthase regulator Stf2p; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	ribosome|nucleus|cytoplasm
YML117W	YML117W	NAB6	hom	Verified	0.927770456072992	0.176763326121061	no	867	0.173209771091601	572	NA					Putative RNA-binding protein that associates with mRNAs encoding cell wall proteins in high-throughput studies; deletion mutants display increased sensitivity to some cell wall disrupting agents; expression negatively regulated by cAMP	biological_process	molecular_function	cytoplasm
YIL119C	YIL119C	RPI1	hom	Verified	0.926076096450276	0.177203217669027	no	868	0.160888304091513	551	NA	FT	SIGNALING	NUCLEUS		Transcription factor with allelic differences between S288C and Sigma1278b; mediates fermentation stress tolerance by modulating cell wall integrity; overexpression suppresses heat shock sensitivity of wild-type RAS2 overexpression and also suppresses cell lysis defect of mpk1 mutation; allele from S288c can confer fMAPK pathway independent transcription of FLO11; S288C and Sigma1278b alleles differ in number of tandem repeats within ORF	fungal-type cell wall biogenesis|Ras protein signal transduction|positive regulation of transcription from RNA polymerase II promoter	small GTPase regulator activity	nucleus
YPL048W	YPL048W	CAM1	hom	Verified	0.925339404147878	0.17739469402796	no	869	0.181590401551257	637	NA	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION	NUCLEUS		Nuclear protein required for transcription of MXR1; binds the MXR1 promoter in the presence of other nuclear factors; binds calcium and phospholipids; has similarity to translational cofactor EF-1 gamma	ribosome biogenesis|positive regulation of transcription from RNA polymerase II promoter	phospholipid binding|transcription coactivator activity|calcium ion binding	nucleus
YGL161C	YGL161C	YIP5	hom	Verified	0.925054490678432	0.1774687819326	no	870	0.182803892752621	634	NA	FT		GOLGI APPARATUS		Protein that interacts with Rab GTPases, localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport	biological_process	Rab GTPase binding	integral to membrane|Golgi apparatus
YMR199W	YMR199W	CLN1	hom	Verified	0.921683453877186	0.178346856834529	no	871	0.15716277741297	581	NA	FT	CELL CYCLE|CELL DIVISION|PROTEIN PHOSPHORYLATION	NUCLEUS		G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p)	regulation of cyclin-dependent protein kinase activity	cyclin-dependent protein kinase regulator activity	nucleus|cytoplasm
YCR015C_p	YCR015C	YCR015C	hom	Uncharacterized	0.921578544726662	0.178374227021651	no	872	0.163261499418635	570	NA					Putative protein of unknown function; YCR015C is not an essential gene	biological_process	molecular_function	cellular_component
YOR062C_p	YOR062C	YOR062C	hom	Uncharacterized	0.921156720834651	0.178484305133085	no	873	0.157743074908794	539	NA	FT		NUCLEUS		Protein of unknown function; similar to YKR075Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS	biological_process	molecular_function	nucleus|cytoplasm
YNL246W	YNL246W	VPS75	hom	Verified	0.919895363977421	0.178813720889624	no	874	0.202083872840638	702	NA	FT	PROTEIN LOCALIZATION|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		NAP family histone chaperone; binds to histones and Rtt109p, stimulating histone acetyltransferase activity; possesses nucleosome assembly activity in vitro; proposed role in vacuolar protein sorting and in double-strand break repair; protein abundance increases in response to DNA replication stress	double-strand break repair via nonhomologous end joining|nucleosome assembly|positive regulation of histone acetylation	histone binding|acetyltransferase activator activity	chromatin|nucleus
YNL070W	YNL070W	TOM7	hom	Verified	0.918613805458167	0.179148804193716	no	875	0.199631132241518	708	NA	FF|FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex	protein import into mitochondrial matrix|protein import into mitochondrial outer membrane	protein channel activity	mitochondrial outer membrane|mitochondrion|integral to membrane|mitochondrial outer membrane translocase complex
YGR087C	YGR087C	PDC6	hom	Verified	0.918423471967756	0.179198603495722	no	876	0.176564147358523	597	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Minor isoform of pyruvate decarboxylase, decarboxylates pyruvate to acetaldehyde, involved in amino acid catabolism; transcription is glucose- and ethanol-dependent, and is strongly induced during sulfur limitation	L-phenylalanine catabolic process|ethanol metabolic process|tryptophan catabolic process|aromatic amino acid family catabolic process to alcohol via Ehrlich pathway	pyruvate decarboxylase activity	cytoplasm
YGL178W	YGL178W	MPT5	hom	Verified	0.917970130660224	0.179317251844084	no	877	0.154648958630435	545	NA	FT	TRANSLATION			mRNA-binding protein of the PUF family; binds to the 3' UTR of specific mRNAs, including those involved in mating type switching, cell wall integrity, chronological lifespan, chromatin modification, and spindle pole body architecture; recruits the CCR4-NOT deadenylase complex to mRNAs along with Dhh1p and Dcp1p to promote deadenylation, decapping, and decay; also interacts with the Caf20p translational initiation repressor, affecting its mRNA target specificity	negative regulation of translation|negative regulation of translational initiation|Unknown	mRNA binding|protein binding, bridging	cytoplasm
YBR089C-A	YBR089C-A	NHP6B	hom	Verified	0.916042939481879	0.179822186902261	no	878	0.150650211091273	500	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		High-mobility group (HMG) protein, binds to and remodels nucleosomes; involved in recruiting FACT and other chromatin remodelling complexes to the chromosomes; functionally redundant with Nhp6Ap; homologous to mammalian HMGB1 and HMGB2; NHP6B has a paralog, NHP6A, that arose from the whole genome duplication	RNA polymerase III transcriptional preinitiation complex assembly|chromatin remodeling|transcription from RNA polymerase II promoter	nucleosome binding|DNA binding, bending|sequence-specific DNA binding	nucleus
YGR089W	YGR089W	NNF2	hom	Verified	0.915802625741263	0.179885213039474	no	879	0.161472178574866	566	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein that exhibits physical and genetic interactions with Rpb8p, which is a subunit of RNA polymerases I, II, and III; computational analysis of large-scale protein-protein interaction data suggests a role in chromosome segregation	biological_process	molecular_function	integral to membrane
YIL113W	YIL113W	SDP1	hom	Verified	0.911591567019386	0.180991881645571	no	880	0.197806936150625	671	NA	FT	SIGNALING|CELL WALL ORG/BIOGENESIS|PROTEIN PHOSPHORYLATION	NUCLEUS		Stress-inducible dual-specificity MAP kinase phosphatase, negatively regulates Slt2p MAP kinase by direct dephosphorylation, diffuse localization under normal conditions shifts to punctate localization after heat shock	inactivation of MAPK activity involved in cell wall biogenesis|MAPK cascade involved in cell wall biogenesis	MAP kinase tyrosine phosphatase activity	nucleus|cytoplasm
YHR117W	YHR117W	TOM71	hom	Verified	0.910565256339439	0.181262241890478	no	881	0.167026109996909	611	NA	FT		MITOCHONDRION		Mitochondrial outer membrane protein; probable minor component of the TOM (translocase of outer membrane) complex responsible for recognition and import of mitochondrially directed proteins; TOM71 has a paralog, TOM70, that arose from the whole genome duplication	biological_process	protein transporter activity	mitochondrial outer membrane|mitochondrion|integral to membrane|integral to mitochondrial outer membrane
YNL277W-A_p	YNL277W-A	YNL277W-A	hom	Uncharacterized	0.907051625171632	0.182189748841406	no	882	0.148166419741375	478	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YHR116W	YHR116W	COX23	hom	Verified	0.906063359509151	0.182451158765815	no	883	0.178591039205617	598	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial intermembrane space protein that functions in mitochondrial copper homeostasis, essential for functional cytochrome oxidase expression; homologous to Cox17p; contains twin cysteine-x9-cysteine motifs	mitochondrial respiratory chain complex assembly	molecular_function	mitochondrion|cytoplasm
YBR050C	YBR050C	REG2	hom	Verified	0.905646587596048	0.182561470902115	no	884	0.146657393679123	464	NA	FT	TRANSCRIPTION FROM RNA POL II			Regulatory subunit of the Glc7p type-1 protein phosphatase; involved with Reg1p, Glc7p, and Snf1p in regulation of glucose-repressible genes, also involved in glucose-induced proteolysis of maltose permease	negative regulation of transcription from RNA polymerase II promoter	protein phosphatase type 1 regulator activity	protein phosphatase type 1 complex
YCR044C	YCR044C	PER1	hom	Verified	0.904566816242693	0.182847460939224	no	885	0.293635621086078	979	NA	FF|FT	LIPID METABOLISM|ION HOMEOSTASIS|ION HOMEOSTASIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein of the endoplasmic reticulum, required for GPI-phospholipase A2 activity that remodels the GPI anchor as a prerequisite for association of GPI-anchored proteins with lipid rafts; functionally complemented by human ortholog PERLD1	GPI anchor biosynthetic process|cellular manganese ion homeostasis	molecular_function	fungal-type vacuole membrane|integral to membrane|endoplasmic reticulum
YPL111W	YPL111W	CAR1	hom	Verified	0.904011527218365	0.182994644534382	no	886	0.194672449735121	675	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS|SITE OF POLARIZED GROWTH		Arginase, responsible for arginine degradation, expression responds to both induction by arginine and nitrogen catabolite repression; disruption enhances freeze tolerance	regulation of ornithine metabolic process|arginine catabolic process to ornithine	manganese ion binding|arginase activity|ornithine carbamoyltransferase inhibitor activity|zinc ion binding	cytosol|nucleus|mating projection tip|cytoplasm
YPL138C	YPL138C	SPP1	hom	Verified	0.903441783028251	0.183145736395187	no	887	0.187691868669994	643	NA	FT	CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS		Subunit of COMPASS (Set1C), a complex which methylates histone H3 on lysine 4 and is required in telomeric transcriptional silencing; interacts with Orc2p; PHD finger domain protein similar to human CGBP, an unmethylated CpG binding protein	histone H3-K4 methylation|regulation of transcription, DNA-dependent|chromatin silencing at telomere	histone methyltransferase activity (H3-K4 specific)|chromatin binding|methylated histone residue binding	Set1C/COMPASS complex
YBR001C	YBR001C	NTH2	hom	Verified	0.902947380760775	0.183276911188117	no	888	0.227385972361612	828	NA	FF|FT	CARBOHYDRATE METABOLISM	MITOCHONDRION		Putative neutral trehalase, required for thermotolerance; may mediate resistance to other cellular stresses; NTH2 has a paralog, NTH1, that arose from the whole genome duplication	trehalose catabolic process	alpha,alpha-trehalase activity	mitochondrion|cytoplasm
YPR099C_d	YPR099C	YPR099C	hom	Dubious	0.902061163955195	0.18351218879013	no	889	0.183453351013487	644	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene MRPL51/YPR100W	Unknown	Unknown	Unknown
YKL009W	YKL009W	MRT4	hom	Verified	0.902053081904188	0.183514335322348	no	890	0.198120793147989	661	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Protein involved in mRNA turnover and ribosome assembly, localizes to the nucleolus	nuclear-transcribed mRNA catabolic process|ribosomal large subunit assembly|ribosomal large subunit biogenesis|rRNA processing	LSU rRNA binding	nucleoplasm|nucleolus|nucleus|preribosome, large subunit precursor
YPL201C	YPL201C	YIG1	hom	Verified	0.901184248578153	0.183745182208282	no	891	0.186362690818776	663	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS		Protein that interacts with glycerol 3-phosphatase and plays a role in anaerobic glycerol production; localizes to the nucleus and cytosol	glycerol biosynthetic process	molecular_function	cytosol|nucleus
YLR342W	YLR342W	FKS1	hom	Verified	0.900645215249982	0.183888492935395	no	892	0.185834530895946	656	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	MITOCHONDRION|PLASMA MEMBRANE|CYTOSKELETON		Catalytic subunit of 1,3-beta-D-glucan synthase, functionally redundant with alternate catalytic subunit Gsc2p; binds to regulatory subunit Rho1p; involved in cell wall synthesis and maintenance; localizes to sites of cell wall remodeling	(1->3)-beta-D-glucan biosynthetic process|positive regulation of endocytosis|regulation of cell size	1,3-beta-D-glucan synthase activity	mitochondrion|1,3-beta-D-glucan synthase complex|integral to membrane|plasma membrane|cellular bud neck|cellular bud tip|actin cortical patch
YDR114C_p	YDR114C	YDR114C	hom	Uncharacterized	0.90055284849967	0.183913057113999	no	893	0.203285492375897	691	NA					Putative protein of unknown function; deletion mutant exhibits poor growth at elevated pH and calcium	biological_process	molecular_function	cellular_component
YOR316C-A_p	YOR316C-A	YOR316C-A	hom	Uncharacterized	0.900391754222909	0.183955903703375	no	894	0.159147617938257	517	NA					Putative protein of unknown function; identified by fungal homology and RT-PCR	biological_process	molecular_function	cellular_component
YBR078W	YBR078W	ECM33	hom	Verified	0.897703025728272	0.184671947967613	no	895	0.269064291068053	887	NA	FF|FT	CELL WALL ORG/BIOGENESIS	MITOCHONDRION|PLASMA MEMBRANE		GPI-anchored protein of unknown function, has a possible role in apical bud growth; GPI-anchoring on the plasma membrane crucial to function; phosphorylated in mitochondria; similar to Sps2p and Pst1p	fungal-type cell wall organization	molecular_function	mitochondrion|fungal-type cell wall|plasma membrane
YML058W	YML058W	SML1	hom	Verified	0.897553097241077	0.184711926868079	no	896	0.134579876905228	481	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|MITOCHONDRION ORGANIZATION	NUCLEUS		Ribonucleotide reductase inhibitor involved in regulating dNTP production; regulated by Mec1p and Rad53p during DNA damage and S phase	mitochondrion organization|response to DNA damage stimulus	enzyme inhibitor activity	nucleus|cytoplasm
YJL105W	YJL105W	SET4	hom	Verified	0.897100519384069	0.184832640803046	no	897	0.192111525153425	690	NA	FT	CHROMATIN ORGANIZATION			Protein of unknown function, contains a SET domain; SET4 has a paralog, SET3, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YOL033W	YOL033W	MSE1	hom	Verified	0.896526016412119	0.184985945851278	no	898	0.222372109768391	734	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial glutamyl-tRNA synthetase, predicted to be palmitoylated	mitochondrial glutamyl-tRNA aminoacylation|glutamyl-tRNA aminoacylation|mitochondrial translation	glutamate-tRNA(Gln) ligase activity|glutamate-tRNA ligase activity	mitochondrion
YBR241C_p	YBR241C	YBR241C	hom	Uncharacterized	0.895771152674595	0.185187499898973	no	899	0.127450261750993	474	NA					Putative transporter, member of the sugar porter family; green fluorescent protein (GFP)-fusion protein localizes to the vacuolar membrane; YBR241C is not an essential gene	transport|transmembrane transport	substrate-specific transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane|membrane
YCL001W	YCL001W	RER1	hom	Verified	0.894902936543732	0.185419488429067	no	900	0.174834490120786	584	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Protein involved in retention of membrane proteins, including Sec12p, in the ER; localized to Golgi; functions as a retrieval receptor in returning membrane proteins to the ER	protein retention in ER lumen|retrograde vesicle-mediated transport, Golgi to ER|ER to Golgi vesicle-mediated transport	molecular_function	COPI-coated vesicle|integral to membrane|ER to Golgi transport vesicle
YCR066W	YCR066W	RAD18	hom	Verified	0.893945028772603	0.185675651907884	no	901	0.210864203322603	787	NA	FF|FT	RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		E3 ubiquitin ligase; forms heterodimer with Rad6p to monoubiquitinate PCNA-K164; heterodimer binds single-stranded DNA and has single-stranded DNA dependent ATPase activity; required for postreplication repair; SUMO-targeted ubiquitin ligase (STUbl) that contains a SUMO-interacting motif (SIM) which stimulates its ubiquitin ligase activity towards the sumoylated form of PCNA	protein monoubiquitination|error-free translesion synthesis|error-free postreplication DNA repair|error-prone translesion synthesis	ubiquitin-protein ligase activity|single-stranded DNA-dependent ATPase activity|single-stranded DNA binding	nuclear chromatin|nucleus
YML035C	YML035C	AMD1	hom	Verified	0.89220642276067	0.186141150114392	no	902	0.185348037516963	636	NA	FT	NUCLEOTIDE METABOLISM			AMP deaminase; tetrameric enzyme that catalyzes the deamination of AMP to form IMP and ammonia; thought to be involved in regulation of intracellular purine (adenine, guanine, and inosine) nucleotide pools	guanine salvage|purine nucleotide metabolic process	AMP deaminase activity	cytoplasm
YGR146C	YGR146C	ECL1	hom	Verified	0.891860785030479	0.186233778042398	no	903	0.194398173183895	639	NA					Protein of unknown function; mitochondrial-dependent role in the extension of chronological lifespan; overexpression increases oxygen consumption and respiratory activity while deletion results in reduced oxygen consumption under conditions of caloric restriction; induced by iron homeostasis transcription factor Aft2p; multicopy suppressor of temperature sensitive hsf1 mutant; induced by treatment with 8-methoxypsoralen and UVA irradiation	biological_process	molecular_function	cellular_component
YGR078C	YGR078C	PAC10	hom	Verified	0.888988172588742	0.18700471813721	no	904	0.224554217085918	768	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS			Part of the heteromeric co-chaperone GimC/prefoldin complex, which promotes efficient protein folding	tubulin complex assembly	tubulin binding	prefoldin complex|polysome|cytoplasm
YER062C	YER062C	HOR2	hom	Verified	0.888874972851831	0.187035138604192	no	905	0.162416332953005	528	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS		Glycerol-1-phosphatase involved in glycerol biosynthesis; induced in response to hyperosmotic or oxidative stress, and during diauxic shift; HOR2 has a paralog, RHR2, that arose from the whole genome duplication	cellular carbohydrate metabolic process|glycerol biosynthetic process|response to osmotic stress	glycerol-1-phosphatase activity	nucleus|cytoplasm
YHR115C	YHR115C	DMA1	hom	Verified	0.887449758075019	0.187418402224899	no	906	0.196787447004831	703	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION			Ubiquitin-protein ligase (E3); controls septin dynamics and the spindle position checkpoint (SPOC) along with functionally redundant ligase Dma2p by regulating the recruitment of Elm1p to the bud neck; regulates levels of the translation initiation factor eIF2 subunit Gcd11p, as well as abundance, localization, and ubiquitination of Cdk inhibitory kinase Swe1p; ubiquitinates cyclin Pcl1p; ortholog of human RNF8 protein, similar to human Chfr; contains FHA and RING finger	establishment of mitotic spindle orientation|protein autoubiquitination|septin ring assembly|mitotic cell cycle spindle assembly checkpoint	ubiquitin-protein ligase activity	cytoplasm
YIL017C	YIL017C	VID28	hom	Verified	0.885429105302449	0.187962620218573	no	907	0.191482448468274	632	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|CARBOHYDRATE METABOLISM|PROTEOLYSIS	NUCLEUS		GID Complex subunit, serves as adaptor for regulatory subunit Vid24p; protein involved in proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBPase); localized to the nucleus and the cytoplasm	negative regulation of gluconeogenesis|proteasomal ubiquitin-dependent protein catabolic process|vacuolar protein catabolic process|ascospore formation|positive regulation of transcription from RNA polymerase II promoter	molecular_function	nucleus|GID complex|cytoplasm
YAR047C_d	YAR047C	YAR047C	hom	Dubious	0.884879037366892	0.18811093759141	no	908	0.174956711414781	607	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YMR025W	YMR025W	CSI1	hom	Verified	0.88429646078954	0.188268099157704	no	909	0.17446647898927	592	NA	FT	SIGNALING	NUCLEUS		Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling; functional equivalent of canonical Csn6 subunit of the COP9 signalosome	adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion|cullin deneddylation	molecular_function	signalosome
YMR118C_p	YMR118C	SHH3	hom	Uncharacterized	0.882931020193762	0.188636771122695	no	910	0.166115553014648	560	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Putative mitochondrial inner membrane protein of unknown function; although similar to Sdh3p, Shh3p is not a stoichiometric subunit of either succinate dehydrogenase or of the TIM22 translocase	biological_process	molecular_function	integral to membrane
YJR025C	YJR025C	BNA1	hom	Verified	0.882234246655974	0.188825072896923	no	911	0.183280310303784	630	NA	FT	OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM	NUCLEUS		3-hydroxyanthranilic acid dioxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p	de novo NAD biosynthetic process from tryptophan	3-hydroxyanthranilate 3,4-dioxygenase activity	cytoplasm
YER031C	YER031C	YPT31	hom	Verified	0.881837348632582	0.188932385625732	no	912	0.246448466890467	847	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING	ENDOMEMBRANE SYSTEM|MITOCHONDRION|GOLGI APPARATUS		Rab family GTPase; involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; YPT31 has a paralog, YPT32, that arose from the whole genome duplication	early endosome to Golgi transport|vesicle-mediated transport|exocytosis	GTPase activity	mitochondrial outer membrane|endosome|Golgi apparatus
YMR205C	YMR205C	PFK2	hom	Verified	0.880907799135397	0.18918386292118	no	913	0.288404135805518	993	NA	FT	CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Beta subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes	proton transport|glycolysis	mRNA binding|6-phosphofructokinase activity	mitochondrion|6-phosphofructokinase complex|cytoplasm
YDR443C	YDR443C	SSN2	hom	Verified	0.880062110958874	0.189412831615471	no	914	0.206200981922516	696	NA	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for stable association of Srb10p-Srb11p kinase; essential for transcriptional regulation	negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter by galactose	RNA polymerase II transcription coactivator activity|RNA polymerase II transcription factor recruiting transcription factor activity	mediator complex
YLR213C	YLR213C	CRR1	hom	Verified	0.878964183628761	0.18971034797197	no	915	0.173610239616893	580	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM			Putative glycoside hydrolase of the spore wall envelope; required for normal spore wall assembly, possibly for cross-linking between the glucan and chitosan layers; expressed during sporulation	ascospore wall assembly	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	ascospore wall
YOR029W_d	YOR029W	YOR029W	hom	Dubious	0.877805551626161	0.190024625595374	no	916	0.149744527377271	489	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YFR006W_p	YFR006W	YFR006W	hom	Uncharacterized	0.877615838807958	0.190076115454586	no	917	0.182475227276872	610	NA					Putative X-Pro aminopeptidase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YFR006W is not an essential gene	biological_process	molecular_function	cytoplasm
YJL060W	YJL060W	BNA3	hom	Verified	0.877457682999361	0.190119046994875	no	918	0.188809433883239	647	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		Kynurenine aminotransferase, catalyzes formation of kynurenic acid from kynurenine; potential Cdc28p substrate	kynurenic acid biosynthetic process	arylformamidase activity|kynurenine-oxoglutarate transaminase activity	mitochondrion|cytoplasm
YDL026W_d	YDL026W	YDL026W	hom	Dubious	0.877376853524944	0.190140990531053	no	919	0.20171876066659	697	NA					Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YEL028W_d	YEL028W	YEL028W	hom	Dubious	0.876368327496201	0.190414915396046	no	920	0.213414297724349	743	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YPL035C_d	YPL035C	YPL035C	hom	Dubious	0.874447583242901	0.190937276912565	no	921	0.194605418232875	671	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YPL034W; YPL035C is not an essential gene	Unknown	Unknown	Unknown
YJL182C_d	YJL182C	YJL182C	hom	Dubious	0.872433438558183	0.191485982580552	no	922	0.190535366550851	660	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized ORF YJL181W	Unknown	Unknown	Unknown
YER081W	YER081W	SER3	hom	Verified	0.871834128988307	0.191649436493167	no	923	0.192961233240674	606	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS			3-phosphoglycerate dehydrogenase; catalyzes the first step in serine and glycine biosynthesis; SER3 has a paralog, SER33, that arose from the whole genome duplication	serine family amino acid biosynthetic process	phosphoglycerate dehydrogenase activity	cytoplasm
YBR019C	YBR019C	GAL10	hom	Verified	0.8713427938881	0.191783505497012	no	924	0.182632472252936	654	NA	FT	CARBOHYDRATE METABOLISM			UDP-glucose-4-epimerase, catalyzes the interconversion of UDP-galactose and UDP-D-glucose in galactose metabolism; also catalyzes the conversion of alpha-D-glucose or alpha-D-galactose to their beta-anomers	galactose catabolic process via UDP-galactose	aldose 1-epimerase activity|UDP-glucose 4-epimerase activity	cytosol
YDL124W	YDL124W	YDL124W	hom	Verified	0.870636240915319	0.191976400935103	no	925	0.161515474580305	570	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		NADPH-dependent alpha-keto amide reductase; reduces aromatic alpha-keto amides, aliphatic alpha-keto esters, and aromatic alpha-keto esters; member of the aldo-keto reductase (AKR) family; protein abundance increases in response to DNA replication stress	cellular response to oxidative stress|cellular ketone metabolic process|cellular amide metabolic process|cellular aromatic compound metabolic process	alpha-keto amide reductase activity|aldo-keto reductase (NADP) activity|alditol:NADP+ 1-oxidoreductase activity|alpha-keto ester reductase activity	nucleus|plasma membrane|cytoplasm
YLR225C_p	YLR225C	YLR225C	hom	Uncharacterized	0.868940735759572	0.19243977351228	no	926	0.199452409557979	700	NA	FT	RESPONSE TO OXIDATIVE STRESS			Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR225C is not an essential gene	biological_process	molecular_function	cytoplasm
YGL158W	YGL158W	RCK1	hom	Verified	0.866332280494523	0.193153984424672	no	927	0.169571595957353	568	NA	FT	CELL CYCLE|PROTEIN PHOSPHORYLATION			Protein kinase involved in the response to oxidative stress; identified as suppressor of S. pombe cell cycle checkpoint mutations; RCK1 has a paralog, RCK2, that arose from the whole genome duplication	protein phosphorylation|regulation of meiosis	protein serine/threonine kinase activity|protein kinase activity	cellular_component
YBR054W	YBR054W	YRO2	hom	Verified	0.865276094329348	0.193443634266422	no	928	0.174185900824658	621	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Protein of unknown function with similarity to archaeal rhodopsins; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; transcriptionally regulated by Haa1p; YRO2 has a paralog, MRH1, that arose from the whole genome duplication	biological_process	molecular_function	mitochondrion|integral to membrane|cellular bud
YOL132W	YOL132W	GAS4	hom	Verified	0.865031338895795	0.193510794107848	no	929	0.180438870890521	598	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	PLASMA MEMBRANE		1,3-beta-glucanosyltransferase, involved with Gas2p in spore wall assembly; has similarity to Gas1p; localizes to the cell wall	ascospore wall assembly	1,3-beta-glucanosyltransferase activity	fungal-type cell wall|integral to membrane
YNL175C	YNL175C	NOP13	hom	Verified	0.864485340325549	0.193660665018489	no	930	0.210642926704678	738	NA	FT		NUCLEUS		Nucleolar protein found in preribosomal complexes; contains an RNA recognition motif (RRM); relative distribution to the nucleolus increases upon DNA replication stress	biological_process	RNA binding	nucleolus|preribosome
YDR347W	YDR347W	MRP1	hom	Verified	0.861274436046855	0.194543455939091	no	931	0.206369442863612	705	NA	FT	TRANSLATION|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the small subunit; MRP1 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator, and with PET123, encoding a small subunit mitochondrial ribosomal protein	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YNL322C	YNL322C	KRE1	hom	Verified	0.860040966929244	0.194883230217484	no	932	0.209963253369484	764	NA	FT	CELL WALL ORG/BIOGENESIS	PLASMA MEMBRANE		Cell wall glycoprotein involved in beta-glucan assembly; serves as a K1 killer toxin membrane receptor	fungal-type cell wall organization	structural constituent of cell wall	fungal-type cell wall|integral to membrane
YBL053W_d	YBL053W	YBL053W	hom	Dubious	0.857824338098128	0.195494734243228	no	933	0.192992307681154	675	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDR225W	YDR225W	HTA1	hom	Verified	0.857409305049889	0.195609359286713	no	934	0.20355236717225	723	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME	RSC COMPLEX	Histone H2A, core histone protein required for chromatin assembly and chromosome function; one of two nearly identical subtypes (see also HTA2); DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p	DNA repair|chromatin assembly or disassembly|negative regulation of transcription from RNA polymerase II promoter	DNA binding	replication fork protection complex|nuclear nucleosome
YER048C	YER048C	CAJ1	hom	Verified	0.857176060579312	0.195673795334687	no	935	0.183696612512167	631	NA	FT		NUCLEUS		Nuclear type II J heat shock protein of the E. coli dnaJ family, contains a leucine zipper-like motif, binds to non-native substrates for presentation to Ssa3p, may function during protein translocation, assembly and disassembly	protein folding	chaperone binding	nucleus
YGL026C	YGL026C	TRP5	hom	Verified	0.85701424665168	0.195718505571887	no	936	0.279487824233685	985	NA	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Tryptophan synthase, catalyzes the last step of tryptophan biosynthesis; regulated by the general control system of amino acid biosynthesis	tryptophan biosynthetic process	tryptophan synthase activity	nucleus|cytoplasm
YOL113W	YOL113W	SKM1	hom	Verified	0.85507818924277	0.196253931620325	no	937	0.211744698681908	754	NA	FT	CELL DIVISION|PROTEIN PHOSPHORYLATION	NUCLEUS|PLASMA MEMBRANE		Member of the PAK family of serine/threonine protein kinases with similarity to Ste20p and Cla4p; involved in down-regulation of sterol uptake; proposed to be a downstream effector of Cdc42p during polarized growth	negative regulation of gene expression|cytokinetic cell separation|protein phosphorylation|sterol import	protein serine/threonine kinase activity|protein kinase activity	plasma membrane|nucleus
YLR240W	YLR240W	VPS34	hom	Verified	0.854358426836427	0.196453211632947	no	938	0.20998544982134	756	NA	FT	PROTEIN LOCALIZATION|LIPID METABOLISM|SIGNALING|PROTEIN PHOSPHORYLATION|PEROXISOME ORGANIZATION	GOLGI APPARATUS		Phosphatidylinositol (PI) 3-kinase that synthesizes PI-3-phosphate; forms membrane-associated signal transduction complex with Vps15p to regulate protein sorting; activated by the GTP-bound form of Gpa1p; a fraction is localized, with Vps15p, to nuclear pores at nucleus-vacuole junctions and may facilitate transcription elongation for genes positioned at the nuclear periphery	peroxisome degradation|phosphatidylinositol phosphorylation|protein phosphorylation	1-phosphatidylinositol-3-kinase activity|protein kinase activity	endosome|fungal-type vacuole membrane|phosphatidylinositol 3-kinase complex I|phosphatidylinositol 3-kinase complex II|peroxisome|pre-autophagosomal structure
YBR031W	YBR031W	RPL4A	hom	Verified	0.853820113204649	0.196602334200966	no	939	0.187295061934009	676	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L4A; N-terminally acetylated; homologous to mammalian ribosomal protein L4 and bacterial L4; RPL4A has a paralog, RPL4B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YAL023C	YAL023C	PMT2	hom	Verified	0.853222082064951	0.196768079978919	no	940	0.231246967550172	779	NA	FT	PROTEIN LOCALIZATION|CARBOHYDRATE METABOLISM|PROTEOLYSIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein O-mannosyltransferase of the ER membrane; transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; involved in ER quality control; acts in a complex with Pmt1p, can instead interact with Pmt5p; antifungal drug target; PMT2 has a paralog, PMT3, that arose from the whole genome duplication	ER-associated misfolded protein catabolic process|protein O-linked glycosylation|Unknown|protein exit from endoplasmic reticulum|protein O-linked mannosylation	dolichyl-phosphate-mannose-protein mannosyltransferase activity	integral to membrane|dolichyl-phosphate-mannose-protein mannosyltransferase complex
YDR480W	YDR480W	DIG2	hom	Verified	0.853139083223314	0.196791089994126	no	941	0.184013116968588	661	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		MAP kinase-responsive inhibitor of the Ste12p transcription factor, involved in the regulation of mating-specific genes and the invasive growth pathway; related regulators Dig1p and Dig2p bind to Ste12p	negative regulation of transcription from RNA polymerase II promoter by pheromones|Unknown	transcription factor binding	nucleus
YNL206C	YNL206C	RTT106	hom	Verified	0.853132978638665	0.196792782450576	no	942	0.211677494493499	740	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS|CHROMOSOME		Histone chaperone, involved in regulation of chromatin structure in both transcribed and silenced chromosomal regions; affects transcriptional elongation; has a role in regulation of Ty1 transposition	DNA replication-independent nucleosome assembly|negative regulation of transcription from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|DNA replication-dependent nucleosome assembly|heterochromatin assembly involved in chromatin silencing	double-stranded DNA binding|histone binding	nucleus
YOR067C	YOR067C	ALG8	hom	Verified	0.852804737613097	0.196883798121685	no	943	0.240658812685228	853	NA	FF|FT	LIPID METABOLISM|CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Glucosyl transferase, involved in N-linked glycosylation; adds glucose to the dolichol-linked oligosaccharide precursor prior to transfer to protein during lipid-linked oligosaccharide biosynthesis; similar to Alg6p	oligosaccharide-lipid intermediate biosynthetic process|protein N-linked glycosylation	dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity	integral to membrane|endoplasmic reticulum membrane
YOR299W	YOR299W	BUD7	hom	Verified	0.852668453469284	0.196921594890385	no	944	0.192801460593204	632	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL CYCLE|CELL WALL ORG/BIOGENESIS|CELL DIVISION|CARBOHYDRATE METABOLISM	GOLGI APPARATUS		Member of the ChAPs family (Chs5p-Arf1p-binding proteins); members include Bch1p, Bch2p, Bud7p, and Chs6p; ChAPs family proteins form the exomer complex with Chs5p to mediate export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; BUD7 has a paralog, BCH1, that arose from the whole genome duplication	Golgi to plasma membrane transport|fungal-type cell wall chitin biosynthetic process|cellular bud site selection	molecular_function	trans-Golgi network transport vesicle|clathrin-coated vesicle|exomer complex
YOR134W	YOR134W	BAG7	hom	Verified	0.852223609726353	0.19704499752077	no	945	0.200019719366929	703	NA	FT	SIGNALING			Rho GTPase activating protein (RhoGAP), stimulates the intrinsic GTPase activity of Rho1p, which plays a role in actin cytoskeleton organization and control of cell wall synthesis; structurally and functionally related to Sac7p	small GTPase mediated signal transduction	Rho GTPase activator activity	intracellular
YBR111W-A	YBR111W-A	SUS1	hom	Verified	0.851559329691946	0.197229360351631	no	946	0.25547186791185	861	NA	FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE|HISTONE ACETYLTRANSFERASE	Component of both the SAGA histone acetylase and TREX-2 complexes; interacts with RNA polymerase II; involved in mRNA export coupled transcription activation and elongation; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP	poly(A)+ mRNA export from nucleus|regulation of protein localization|nuclear retention of pre-mRNA at the site of transcription|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|histone deubiquitination|histone H3-K4 methylation|transcription elongation from RNA polymerase II promoter|histone H3-K79 methylation|positive regulation of transcription from RNA polymerase II promoter	enzyme activator activity	DUBm complex|nucleoplasm|transcription export complex 2|SAGA complex|nuclear pore
YDR469W	YDR469W	SDC1	hom	Verified	0.851325082672969	0.197294397638278	no	947	0.226491717441875	766	NA	FT	CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS		Subunit of the COMPASS (Set1C) complex, which methylates lysine 4 of histone H3 and is required in chromatin silencing at telomeres; contains a Dpy-30 domain that mediates interaction with Bre2p; similar to C. elegans and human DPY-30	histone H3-K4 methylation|chromatin silencing at telomere	histone methyltransferase activity (H3-K4 specific)	Set1C/COMPASS complex
YLL002W	YLL002W	RTT109	hom	Verified	0.848151003397279	0.198176940059116	no	948	0.204862777772343	709	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE	NUCLEUS		Histone acetyltransferase critical for cell survival in the presence of DNA damage during S phase; acetylates H3-K56 and H3-K9; involved in non-homologous end joining and in regulation of Ty1 transposition; interacts physically with Vps75p	negative regulation of transposition, RNA-mediated|histone acetylation|double-strand break repair via nonhomologous end joining|response to DNA damage stimulus|regulation of transcription from RNA polymerase II promoter in response to stress	H3 histone acetyltransferase activity	nucleus
YOL159C-A	YOL159C-A	YOL159C-A	hom	Verified	0.848041980520382	0.198207295791537	no	949	0.170715287801999	595	NA	FT		NUCLEUS		Protein of unknown function; overexpression affects endocytic protein trafficking; identified by sequence comparison with hemiascomycetous yeast species	biological_process	molecular_function	nucleus|cytoplasm
YDL234C	YDL234C	GYP7	hom	Verified	0.847560097796036	0.198341502194707	no	950	0.163845246272708	553	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING|NUCLEOTIDE METABOLISM			GTPase-activating protein for yeast Rab family members including: Ypt7p (most effective), Ypt1p, Ypt31p, and Ypt32p (in vitro); involved in vesicle mediated protein trafficking	regulation of vacuole fusion, non-autophagic|vesicle-mediated transport	Rab GTPase activator activity	cytoplasm
YPL253C	YPL253C	VIK1	hom	Verified	0.847404844546529	0.19838475256731	no	951	0.201890328142377	715	NA	FT	CELL CYCLE|CHROMOSOME SEGREGATION	NUCLEUS|CYTOSKELETON		Protein that forms a complex with Kar3p at the spindle pole body, possible regulator of Kar3p function in microtubule-mediated processes; required for sister chromatid cohesion; has similarity to Cik1p	microtubule-based process|mitotic sister chromatid cohesion	microtubule motor activity	kinesin complex|spindle pole body
YNL042W-B_p	YNL042W-B	YNL042W-B	hom	Uncharacterized	0.845445373018395	0.19893111020555	no	952	0.168394516463426	591	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YMR247C	YMR247C	RKR1	hom	Verified	0.845326186511724	0.198964372100882	no	953	0.181092729246973	618	NA	FT	CHROMATIN ORGANIZATION|PROTEOLYSIS|GENE SILENCING	NUCLEUS		RING domain E3 ubiquitin ligase; involved in the ubiquitin-mediated degradation of non-stop proteins; functional connections to chromatin modification; nuclear protein that also co-localizes with ribosomes; homolog of mouse Listerin, whose mutation has been reported to cause neurodegeneration in mice	chromatin modification|chromatin silencing at telomere|ubiquitin-dependent protein catabolic process|protein ubiquitination	ubiquitin-protein ligase activity|ribosome binding	ribosome|nucleus
YBR044C	YBR044C	TCM62	hom	Verified	0.844316392366255	0.199246314198365	no	954	0.136657697453171	499	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Protein involved in the assembly of the mitochondrial succinate dehydrogenase complex; putative chaperone	mitochondrial respiratory chain complex II assembly	unfolded protein binding	mitochondrion|mitochondrial inner membrane
YAL028W	YAL028W	FRT2	hom	Verified	0.843798618789465	0.199390973735751	no	955	0.155498316904829	513	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Tail-anchored ER membrane protein of unknown function; interacts with homolog Frt1p; promotes growth in conditions of high Na+, alkaline pH, or cell wall stress, possibly via a role in posttranslational translocation; potential Cdc28p substrate; FRT2 has a paralog, FRT1, that arose from the whole genome duplication	response to stress	molecular_function	endoplasmic reticulum
YBR006W	YBR006W	UGA2	hom	Verified	0.842670630104211	0.199706338684843	no	956	0.247731925110175	877	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS			Succinate semialdehyde dehydrogenase involved in the utilization of gamma-aminobutyrate (GABA) as a nitrogen source; part of the 4-aminobutyrate and glutamate degradation pathways; localized to the cytoplasm	cellular response to oxidative stress|gamma-aminobutyric acid catabolic process|glutamate decarboxylation to succinate	succinate-semialdehyde dehydrogenase [NAD(P)+] activity	cytoplasm
YLR024C	YLR024C	UBR2	hom	Verified	0.841289725012072	0.200092822720008	no	957	0.18305851637035	588	NA					Cytoplasmic ubiquitin-protein ligase (E3); required for ubiquitylation of Rpn4p; mediates formation of a Mub1p-Ubr2p-Rad6p complex	protein monoubiquitination	ubiquitin-protein ligase activity	cytoplasm
YML012C-A_d	YML012C-A	YML012C-A	hom	Dubious	0.839640973447073	0.200554859309114	no	958	0.213138063781615	772	NA	FF				Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene SEL1	Unknown	Unknown	Unknown
YLR270W	YLR270W	DCS1	hom	Verified	0.838506482080666	0.200873154359738	no	959	0.215946083639133	743	NA	FT		NUCLEUS|MITOCHONDRION		Non-essential hydrolase involved in mRNA decapping; activates Xrn1p; may function in a feedback mechanism to regulate deadenylation, contains pyrophosphatase activity and a HIT (histidine triad) motif; interacts with neutral trehalase Nth1p; required for growth on glycerol medium; protein abundance increases in response to DNA replication stress	deadenylation-dependent decapping of nuclear-transcribed mRNA|positive regulation of nuclease activity|nuclear-transcribed mRNA catabolic process, deadenylation-independent decay	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|enzyme activator activity|m7G(5')pppN diphosphatase activity	mitochondrion|nucleus|cytoplasmic mRNA processing body|cytoplasm
YEL053C	YEL053C	MAK10	hom	Verified	0.836606640417756	0.201406855890546	no	960	0.195094012650727	679	NA					Non-catalytic subunit of N-terminal acetyltransferase of the NatC type, required for replication of dsRNA virus; expression is glucose-repressible	N-terminal protein amino acid acetylation	peptide alpha-N-acetyltransferase activity	NatC complex|cytoplasm
YLR290C_p	YLR290C	YLR290C	hom	Uncharacterized	0.836404104320554	0.201463802205194	no	961	0.168144466341297	553	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YLR290C is not an essential gene	biological_process	molecular_function	mitochondrion
YBR273C	YBR273C	UBX7	hom	Verified	0.835637727107447	0.201679368925262	no	962	0.178644286610572	630	NA	FT	PROTEOLYSIS	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM		UBX (ubiquitin regulatory X) domain-containing protein; interacts with Cdc48p; UBX7 has a paralog, UBX6, that arose from the whole genome duplication	sporulation resulting in formation of a cellular spore|ubiquitin-dependent protein catabolic process	molecular_function	nuclear envelope|endoplasmic reticulum
YLR109W	YLR109W	AHP1	hom	Verified	0.834794208327936	0.201916793683769	no	963	0.197089566328656	664	NA	FT	OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS			Thiol-specific peroxiredoxin, reduces hydroperoxides to protect against oxidative damage; function in vivo requires covalent conjugation to Urm1p	cellular response to oxidative stress|response to metal ion|cell redox homeostasis	thioredoxin peroxidase activity	plasma membrane|cytoplasm
YKL118W_d	YKL118W	YKL118W	hom	Dubious	0.834485561119964	0.20200371023698	no	964	0.29760533289462	991	NA	FF				Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene VPH2	Unknown	Unknown	Unknown
YLR407W_p	YLR407W	YLR407W	hom	Uncharacterized	0.834170731587098	0.20209239082934	no	965	0.204745711875637	655	NA					Putative protein of unknown function; null mutant displays elongated buds and a large fraction of budded cells have only one nucleus	biological_process	molecular_function	cellular_component
YDR456W	YDR456W	NHX1	hom	Verified	0.833213300870309	0.202362221232766	no	966	0.207492950343648	713	NA	FF|FT	ION HOMEOSTASIS|ION HOMEOSTASIS	GOLGI APPARATUS		Na+/H+ and K+/H+ exchanger, required for intracellular sequestration of Na+ and K+; located in the vacuole and late endosome compartments; required for osmotolerance to acute hypertonic shock and for vacuolar fusion	sodium ion transmembrane transport|potassium ion transmembrane transport|cellular monovalent inorganic cation homeostasis|vacuolar acidification	sodium:hydrogen antiporter activity|potassium:hydrogen antiporter activity	trans-Golgi network|late endosome|fungal-type vacuole membrane|integral to membrane|early endosome
YBR231C	YBR231C	SWC5	hom	Verified	0.832974862538888	0.202429453231109	no	967	0.241281435571581	853	NA	FF|FT	CHROMATIN ORGANIZATION	NUCLEUS|CHROMOSOME		Component of the SWR1 complex; complex exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; protein abundance increases in response to DNA replication stress	chromatin remodeling|histone exchange	molecular_function	Swr1 complex|nucleus
YGL237C	YGL237C	HAP2	hom	Verified	0.832466662402521	0.202572794010598	no	968	0.189382219443118	662	NA	FT	TRANSCRIPTION FROM RNA POL II|OXIDATION-REDUCTION PROCESS|RESPONSE TO NUTRIENT LEVELS|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS		Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding	carbon catabolite activation of transcription from RNA polymerase II promoter|regulation of cellular respiration	RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	CCAAT-binding factor complex|nucleus
YBL085W	YBL085W	BOI1	hom	Verified	0.832114811723224	0.202672071058835	no	969	0.196187512004427	663	NA	FT	SIGNALING|CELL DIVISION	SITE OF POLARIZED GROWTH		Protein implicated in polar growth; functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; relocalizes from bud neck to cytoplasm upon DNA replication stress; BOI1 has a paralog, BOI2, that arose from the whole genome duplication	cytokinesis, completion of separation|establishment of cell polarity|budding cell apical bud growth|Rho protein signal transduction	phospholipid binding	site of polarized growth|cellular bud|mating projection tip|cellular bud neck
YCR086W	YCR086W	CSM1	hom	Verified	0.83143765339679	0.202863217667971	no	970	0.198528523492295	681	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|CHROMOSOME SEGREGATION	ENDOMEMBRANE SYSTEM|NUCLEUS|CHROMOSOME	KINETOCHORE	Nucleolar protein that forms a complex with Lrs4p and then Mam1p at kinetochores during meiosis I to mediate accurate homolog segregation; required for condensin recruitment to the replication fork barrier site and rDNA repeat segregation	meiotic chromosome segregation|rDNA condensation|protein localization to nucleolar rDNA repeats|homologous chromosome segregation	molecular_function	nuclear envelope|nucleolus|monopolin complex
YOR016C	YOR016C	ERP4	hom	Verified	0.830035706579145	0.203259297924748	no	971	0.188834866411205	610	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport	ER to Golgi vesicle-mediated transport	molecular_function	integral to membrane
YIL108W	YIL108W	YIL108W	hom	Verified	0.829907475372727	0.203295549033979	no	972	0.170477763203533	563	NA	FT	PROTEOLYSIS			Putative metalloendopeptidase; forms cytoplasmic foci upon DNA replication stress	biological_process	molecular_function	cytoplasm
YML072C	YML072C	TCB3	hom	Verified	0.829253254054399	0.203480558200371	no	973	0.2113860505536	729	NA	FT		ENDOPLASMIC RETICULUM|MITOCHONDRION|PLASMA MEMBRANE		Cortical ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; localized to the bud via specific mRNA transport; non-tagged protein detected in a phosphorylated state in mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact	biological_process	lipid binding	mitochondrion|cortical endoplasmic reticulum|cellular bud
YPR077C_d	YPR077C	YPR077C	hom	Dubious	0.828319461675155	0.203744802000787	no	974	0.206405160543993	700	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; expression increased by deletion of NAP1	Unknown	Unknown	Unknown
YDR250C_d	YDR250C	YDR250C	hom	Dubious	0.828261112691653	0.203761320336259	no	975	0.205157971770399	690	NA					Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data	Unknown	Unknown	Unknown
YBR025C	YBR025C	OLA1	hom	Verified	0.827796346695016	0.203892922007901	no	976	0.207080705298606	707	NA					P-loop ATPase with similarity to human OLA1 and bacterial YchF; identified as specifically interacting with the proteasome; protein abundance increases in response to hydrogen peroxide and to DNA replication stress	biological_process	ATPase activity	cytoplasm
YML066C	YML066C	SMA2	hom	Verified	0.827676524004067	0.203926858833921	no	977	0.175570447757646	582	NA	FT	MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS	ENDOPLASMIC RETICULUM		Meiosis-specific prospore membrane protein; required to produce bending force necessary for proper assembly of the prospore membrane during sporulation	ascospore wall assembly|spore membrane bending pathway	molecular_function	integral to membrane|prospore membrane|cytoplasm
YKR078W	YKR078W	YKR078W	hom	Verified	0.827372625773185	0.204012945616145	no	978	0.211077730561108	712	NA					Cytoplasmic protein of unknown function, has similarity to Vps5p; potential Cdc28p substrate; contains a Phox homology (PX) domain and specifically binds phosphatidylinositol 3-phosphate (PtdIns-3-P)	biological_process	phosphatidylinositol-3-phosphate binding	cytoplasm
YDR461W	YDR461W	MFA1	hom	Verified	0.827365645639745	0.204014923168029	no	979	0.208037222330137	697	NA	FT	SIGNALING	PLASMA MEMBRANE		Mating pheromone a-factor, made by a cells; interacts with alpha cells to induce cell cycle arrest and other responses leading to mating; biogenesis involves C-terminal modification, N-terminal proteolysis, and export; also encoded by MFA2	pheromone-dependent signal transduction involved in conjugation with cellular fusion	mating pheromone activity	extracellular region
YIR016W_p	YIR016W	YIR016W	hom	Uncharacterized	0.826797902447464	0.204175809567452	no	980	0.180168956497371	663	NA					Putative protein of unknown function; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p; overexpression causes a cell cycle delay or arrest; non-essential gene; YIR016W has a paralog, YOL036W, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YJL163C_p	YJL163C	YJL163C	hom	Uncharacterized	0.82605493196392	0.204386465776964	no	981	0.193889934005815	646	NA					Putative protein of unknown function	biological_process	molecular_function	integral to membrane
YPL132W	YPL132W	COX11	hom	Verified	0.825910813603809	0.204427342979835	no	982	0.215520164751238	692	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION	RIBOSOME	Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p	protein complex assembly|aerobic respiration	copper ion binding	mitochondrial envelope|mitochondrion|mitochondrial ribosome|mitochondrial inner membrane
YBR276C	YBR276C	PPS1	hom	Verified	0.825708922281222	0.204484614876447	no	983	0.159171301114713	531	NA	FT	CELL CYCLE|SIGNALING|PROTEIN PHOSPHORYLATION	NUCLEUS		Protein phosphatase with specificity for serine, threonine, and tyrosine residues; has a role in the DNA synthesis phase of the cell cycle	inactivation of MAPK activity|protein dephosphorylation|regulation of S phase of mitotic cell cycle	protein tyrosine/serine/threonine phosphatase activity	cellular_component
YBR271W	YBR271W	EFM2	hom	Verified	0.825560405533577	0.204526751736698	no	984	0.235250948864814	792	NA					S-adenosylmethionine-dependent methyltransferase; methylates translation elongation factors EF2 (Eft1p and Eft2p) and EF3A (Yef3p); belongs to the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; predicted to be involved in ribosome biogenesis	peptidyl-lysine methylation	S-adenosylmethionine-dependent methyltransferase activity|protein-lysine N-methyltransferase activity	cytoplasm
YIR007W_p	YIR007W	YIR007W	hom	Uncharacterized	0.82430426237722	0.204883348663205	no	985	0.193651517126121	614	NA	FT	CARBOHYDRATE METABOLISM			Putative glycosidase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YIR007W is a non-essential gene	biological_process	molecular_function	cytoplasm
YGR205W	YGR205W	TDA10	hom	Verified	0.824291389200041	0.204887005044248	no	986	0.176188870924575	615	NA	FT		NUCLEUS		ATP-binding protein of unknown function; crystal structure resembles that of E.coli pantothenate kinase and other small kinases; null mutant is sensitive to expression of the top1-T722A allele	biological_process	ATP binding	nucleus|cytoplasm
YLR190W	YLR190W	MMR1	hom	Verified	0.822885899035413	0.205286441105515	no	987	0.179417241361945	620	NA	FT	CELL CYCLE|CELL DIVISION|MITOCHONDRION ORGANIZATION	MITOCHONDRION|SITE OF POLARIZED GROWTH		Phosphorylated protein of the mitochondrial outer membrane, localizes only to mitochondria of the bud; interacts with Myo2p to mediate mitochondrial distribution to buds; mRNA is targeted to the bud via the transport system involving She2p	mitochondrion inheritance	molecular_function	mitochondrial outer membrane|incipient cellular bud site|mitochondrion|cellular bud|cellular bud neck
YDL185W	YDL185W	VMA1	hom	Verified	0.822107040849721	0.205507989315869	no	988	0.281256808561493	985	NA	FF|FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS	ENDOMEMBRANE SYSTEM		Subunit A of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase; protein precursor undergoes self-catalyzed splicing to yield the extein Tfp1p and the intein Vde (PI-SceI), which is a site-specific endonuclease	intron homing|cellular protein metabolic process|vacuolar acidification	endodeoxyribonuclease activity|proton-transporting ATPase activity, rotational mechanism	vacuolar proton-transporting V-type ATPase, V1 domain|fungal-type vacuole membrane
YBR094W	YBR094W	PBY1	hom	Verified	0.821562841840831	0.205662872337449	no	989	0.18592362915678	619	NA					Putative tubulin tyrosine ligase associated with P-bodies; forms cytoplasmic foci upon DNA replication stress	nuclear-transcribed mRNA catabolic process|biological_process	molecular_function	cytoplasmic mRNA processing body|cytoplasm
YOR047C	YOR047C	STD1	hom	Verified	0.821295469911267	0.205738993721174	no	990	0.210553005874013	684	NA	FT	TRANSCRIPTION FROM RNA POL II|SIGNALING|CARBOHYDRATE METABOLISM	NUCLEUS|PLASMA MEMBRANE		Protein involved in control of glucose-regulated gene expression; interacts with kinase Snf1p, glucose sensors Snf3p and Rgt2p, TATA-binding Spt15p; regulator of transcription factor Rgt1p; interactions with Pma1p appear to propagate [GAR+]	response to salt stress|signal transduction|nicotinamide riboside biosynthetic process|glucose metabolic process|nicotinic acid riboside biosynthetic process|regulation of transcription from RNA polymerase II promoter	protein kinase activator activity	plasma membrane|nucleus
YKL213C	YKL213C	DOA1	hom	Verified	0.820254942772383	0.206035393222338	no	991	0.192654130363898	662	NA	FT	RESPONSE TO DNA DAMAGE|PROTEOLYSIS	NUCLEUS		WD repeat protein required for ubiquitin-mediated protein degradation; forms a complex with Cdc48p; plays a role in controlling cellular ubiquitin concentration; also promotes efficient NHEJ in postdiauxic/stationary phase; protein increases in abundance and relocalizes from nucleus to nuclear periphery upon DNA replication stress	double-strand break repair via nonhomologous end joining|ubiquitin-dependent protein catabolic process	ubiquitin binding	nucleus|cytoplasm
YGL260W_p	YGL260W	YGL260W	hom	Uncharacterized	0.819954094453613	0.20612113858186	no	992	0.189408859055048	638	NA					Putative protein of unknown function; transcription is significantly increased in a NAP1 deletion background; deletion mutant has increased accumulation of nickel and selenium	biological_process	molecular_function	cellular_component
YIR004W	YIR004W	DJP1	hom	Verified	0.819502603685296	0.206249858530905	no	993	0.184403524940506	614	NA	FT	PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION			Cytosolic J-domain-containing protein, required for peroxisomal protein import and involved in peroxisome assembly, homologous to E. coli DnaJ	protein import into peroxisome matrix	chaperone binding	cytosol
YGR213C	YGR213C	RTA1	hom	Verified	0.819172467764491	0.206344010382135	no	994	0.173911036567133	546	NA	FT		PLASMA MEMBRANE		Protein involved in 7-aminocholesterol resistance; has seven potential membrane-spanning regions; expression is induced under both low-heme and low-oxygen conditions; member of the fungal lipid-translocating exporter (LTE) family of protein	biological_process	molecular_function	integral to membrane|plasma membrane
YOL121C	YOL121C	RPS19A	hom	Verified	0.818607177103275	0.206505285422912	no	995	0.209957189750015	693	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; required for assembly and maturation of pre-40 S particles; homologous to mammalian ribosomal protein S19, no bacterial homolog; mutations in human RPS19 are associated with Diamond Blackfan anemia; RPS19A has a paralog, RPS19B, that arose from the whole genome duplication	cytoplasmic translation|ribosomal small subunit biogenesis|rRNA export from nucleus	structural constituent of ribosome	cytosolic small ribosomal subunit
YNL323W	YNL323W	LEM3	hom	Verified	0.818152664472283	0.206635010098019	no	996	0.30071241966398	1051	NA	FF|FT	MEMBRANE ORGANIZATION|SIGNALING	ENDOPLASMIC RETICULUM|PLASMA MEMBRANE		Membrane protein of the plasma membrane and ER, interacts specifically in vivo with the phospholipid translocase (flippase) Dnf1p; involved in translocation of phospholipids and alkylphosphocholine drugs across the plasma membrane	phospholipid translocation|cell surface receptor signaling pathway	phospholipid-translocating ATPase activity	integral to membrane|endoplasmic reticulum|plasma membrane|cytoplasm
YMR130W_p	YMR130W	YMR130W	hom	Uncharacterized	0.818088128290178	0.206653433597669	no	997	0.164139034577914	545	NA					Putative protein of unknown function; YMR130W is not an essential gene	biological_process	molecular_function	cellular_component
YDL088C	YDL088C	ASM4	hom	Verified	0.817966190770474	0.206688246428807	no	998	0.196849056263147	695	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|CELL DIVISION|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	FG-nucleoporin component of central core of nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport; induces membrane tubulation, which may contribute to nuclear pore assembly; ASM4 has a paralog, NUP53, that arose from the whole genome duplication	nuclear pore organization|mRNA export from nucleus in response to heat stress|mitotic cell cycle spindle assembly checkpoint	nucleocytoplasmic transporter activity|phospholipid binding|single-stranded DNA binding	nuclear pore central transport channel|integral to membrane|nuclear pore
YER083C	YER083C	GET2	hom	Verified	0.817498978479613	0.20682166641082	no	999	0.282871981564599	970	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Subunit of the GET complex; involved in insertion of proteins into the ER membrane; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for meiotic nuclear division	retrograde vesicle-mediated transport, Golgi to ER|protein insertion into ER membrane	protein anchor	integral to membrane|endoplasmic reticulum|GET complex
YKR021W	YKR021W	ALY1	hom	Verified	0.816748875284986	0.207035977038324	no	1000	0.202534878786088	674	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION			Alpha arrestin that controls nutrient-mediated intracellular sorting of permease Gap1p; interacts with AP-1 subunit Apl4p; may regulate endocytosis of plasma membrane proteins by recruiting ubiquitin ligase Rsp5p to plasma membrane targets; ALY1 has a paralog, ALY2, that arose from the whole genome duplication	Unknown|regulation of intracellular transport|ubiquitin-dependent endocytosis	ubiquitin protein ligase binding	late endosome|cytoplasm|early endosome
YNR039C	YNR039C	ZRG17	hom	Verified	0.81573687539832	0.207325321814625	no	1001	0.178557690123691	601	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Msc2p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; zinc-regulated directly through Zap1p; transcription induced under conditions of zinc deficiency	zinc ion transport	zinc ion transmembrane transporter activity|metal ion transmembrane transporter activity	integral to membrane|endoplasmic reticulum
YFL018C	YFL018C	LPD1	hom	Verified	0.815608032797628	0.207362176847995	no	1002	0.202047006436603	705	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS	MITOCHONDRION		Dihydrolipoamide dehydrogenase, the lipoamide dehydrogenase component (E3) of the pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase multi-enzyme complexes	L-serine biosynthetic process|2-oxoglutarate metabolic process|leucine catabolic process|glycine catabolic process|isoleucine catabolic process|pyruvate metabolic process|valine catabolic process|hydrogen peroxide metabolic process	glycine dehydrogenase (decarboxylating) activity|pyruvate dehydrogenase activity|oxoglutarate dehydrogenase (succinyl-transferring) activity|dihydrolipoyl dehydrogenase activity	mitochondrial nucleoid|mitochondrion|glycine cleavage complex|mitochondrial oxoglutarate dehydrogenase complex
YKR044W	YKR044W	UIP5	hom	Verified	0.814461191777485	0.207690397874053	no	1003	0.197277340735486	662	NA	FT		ENDOMEMBRANE SYSTEM|NUCLEUS		Protein of unknown function that interacts with Ulp1p, a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates	biological_process	molecular_function	nuclear envelope
YFL063W_d	YFL063W	YFL063W	hom	Dubious	0.814128956585132	0.207785539478996	no	1004	0.163708086971402	547	NA					Dubious open reading frame, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YGR146C-A_p	YGR146C-A	YGR146C-A	hom	Uncharacterized	0.814101446621025	0.207793418612657	no	1005	0.203731538323494	663	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YNL224C	YNL224C	SQS1	hom	Verified	0.81339593643974	0.207995544194353	no	1006	0.200329334124252	720	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEOTIDE METABOLISM	NUCLEUS		Protein that stimulates the ATPase and helicase activities of Prp43p; acts with Prp43p to stimulate 18s rRNA maturation by Nob1p; overexpression antagonizes the suppression of splicing defects by spp382 mutants; component of pre-ribosomal particles; relocalizes from nucleus to nucleolus upon DNA replication stress	positive regulation of helicase activity|positive regulation of ATPase activity|mRNA splicing, via spliceosome|maturation of SSU-rRNA|rRNA processing	molecular_function	preribosome, small subunit precursor|nucleus|preribosome, large subunit precursor|90S preribosome|cytoplasm
YFL007W	YFL007W	BLM10	hom	Verified	0.813378423081328	0.208000563170922	no	1007	0.210270591718557	717	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS	NUCLEUS		Proteasome activator; binds the core proteasome and stimulates proteasome-mediated protein degradation by inducing gate opening; required for resistance to bleomycin, may be involved in protecting against oxidative damage; similar to mammalian PA200	proteasome assembly|regulation of proteasomal protein catabolic process	proteasome binding|peptidase activator activity	proteasome core complex|proteasome complex|integral to membrane|nucleus
YDR307W_p	YDR307W	PMT7	hom	Uncharacterized	0.813361284274439	0.208005474877771	no	1008	0.200812979632575	674	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Putative protein mannosyltransferase similar to Pmt1p; has a potential role in protein O-glycosylation	biological_process	molecular_function	integral to membrane|endoplasmic reticulum
YDR219C	YDR219C	MFB1	hom	Verified	0.811758744575923	0.208465039470309	no	1009	0.186495216573136	626	NA	FT	PROTEOLYSIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION	UBIQUITIN LIGASE COMPLEX	Mitochondria-associated F-box protein involved in maintenance of normal mitochondrial morphology; interacts with Skp1p through the F-box motif; preferentially localizes to the mother cell during budding	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|mitochondrion organization	molecular_function	extrinsic to mitochondrial outer membrane|SCF ubiquitin ligase complex
YJL215C_d	YJL215C	YJL215C	hom	Dubious	0.811613885815212	0.208506610492101	no	1010	0.22217852330712	734	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YFR024C-A	YFR024C-A	LSB3	hom	Verified	0.81042693060862	0.208847422508146	no	1011	0.19353523480235	642	NA	FT		MITOCHONDRION|SITE OF POLARIZED GROWTH		Protein containing a C-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein abundance increases in response to DNA replication stress; LSB3 has a paralog, YSC84, that arose from the whole genome duplication	actin cortical patch localization	molecular_function	mitochondrion|cellular bud neck|cytoplasm
YML103C	YML103C	NUP188	hom	Verified	0.809026890308756	0.209249839524365	no	1012	0.193151754592154	664	NA	FT	PROTEIN LOCALIZATION|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188	nuclear pore organization|protein import into nucleus|mRNA export from nucleus in response to heat stress	structural constituent of nuclear pore	integral to membrane|nuclear pore|nuclear pore inner ring
YML094W	YML094W	GIM5	hom	Verified	0.807120735269075	0.209798463452714	no	1013	0.20455691011867	726	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS			Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it	tubulin complex assembly	tubulin binding	prefoldin complex|cytoplasm
YAR002W	YAR002W	NUP60	hom	Verified	0.806904529210948	0.209860744595601	no	1014	0.227874601002598	768	NA	FT	PROTEIN LOCALIZATION|RESPONSE TO DNA DAMAGE|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier and is involved in gene tethering at the nuclear periphery; both NUP1 and NUP60 are homologous to human NUP153	double-strand break repair|poly(A)+ mRNA export from nucleus|protein export from nucleus|regulation of protein desumoylation|intracellular mRNA localization|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|telomere tethering at nuclear periphery|mRNA export from nucleus in response to heat stress|transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery|NLS-bearing substrate import into nucleus|chromosome organization|nucleocytoplasmic transport|chromatin silencing at silent mating-type cassette	nucleocytoplasmic transporter activity|phospholipid binding|structural constituent of nuclear pore	nuclear pore central transport channel|nuclear pore nuclear basket|integral to membrane|nuclear pore
YHL014C	YHL014C	YLF2	hom	Verified	0.806419319883515	0.21000055540313	no	1015	0.209096868344084	707	NA	FT		MITOCHONDRION		Protein of unknown function, has weak similarity to E. coli GTP-binding protein gtp1; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	GTP binding	mitochondrion
YDR392W	YDR392W	SPT3	hom	Verified	0.806007495398917	0.210119263639261	no	1016	0.268335151800034	925	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION	NUCLEUS	HISTONE ACETYLTRANSFERASE	Subunit of the SAGA and SAGA-like transcriptional regulatory complexes, interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes, also functions to inhibit transcription at some promoters	conjugation with cellular fusion|histone acetylation|pseudohyphal growth|ascospore formation|chromatin modification|invasive growth in response to glucose limitation|transcription from RNA polymerase II promoter	transcription cofactor activity	SLIK (SAGA-like) complex|SAGA complex
YOL047C_p	YOL047C	YOL047C	hom	Uncharacterized	0.805436015154744	0.210284057868947	no	1017	0.198215044016503	637	NA					Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern	biological_process	molecular_function	integral to membrane|cytoplasm
YBR125C	YBR125C	PTC4	hom	Verified	0.805167734357227	0.210361446516309	no	1018	0.182585373802568	619	NA					Cytoplasmic type 2C protein phosphatase (PP2C); identified as a high-copy number suppressor of cnb1 mpk1 synthetic lethality; overexpression decreases high-osmolarity induced Hog1p phosphorylation and kinase activity	protein dephosphorylation	protein serine/threonine phosphatase activity	cytoplasm
YOR123C	YOR123C	LEO1	hom	Verified	0.804931518345399	0.210429599552332	no	1019	0.213728121624571	752	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE	NUCLEUS	RNA POL II, HOLOENZYME	Component of the Paf1 complex; which associates with RNA polymerase II and is involved in histone methylation; plays a role in regulating Ty1 transposition; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay	chromatin organization|Unknown|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription-coupled nucleotide-excision repair|histone H3-K4 trimethylation|transcription elongation from RNA polymerase II promoter	RNA binding|RNA polymerase II transcription factor binding transcription factor activity	nucleus|Cdc73/Paf1 complex
YEL010W_d	YEL010W	YEL010W	hom	Dubious	0.803764538224546	0.210766486756704	no	1020	0.170200894894939	595	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YBL038W	YBL038W	MRPL16	hom	Verified	0.803499205878041	0.210843127785003	no	1021	0.23736568194105	815	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation	structural constituent of ribosome|peptidyltransferase activity	mitochondrion|mitochondrial large ribosomal subunit
YNR052C	YNR052C	POP2	hom	Verified	0.803104694210548	0.210957112364112	no	1022	0.289560661384128	995	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|RNA PROCESSING	NUCLEUS|SITE OF POLARIZED GROWTH		RNase of the DEDD superfamily, subunit of the Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation	regulation of transcription from RNA polymerase II promoter|positive regulation of transcription elongation from RNA polymerase II promoter|nuclear-transcribed mRNA poly(A) tail shortening|transcription elongation from RNA polymerase II promoter	3'-5'-exoribonuclease activity	CCR4-NOT core complex|mating projection tip|cytoplasmic mRNA processing body|cytoplasm
YBL106C	YBL106C	SRO77	hom	Verified	0.802572251268345	0.21111100610915	no	1023	0.274309803300005	952	NA	FF|FT	VESICLE-MEDIATED TRANSPORT	PLASMA MEMBRANE		Protein with roles in exocytosis and cation homeostasis; functions in docking and fusion of post-Golgi vesicles with plasma membrane; homolog of Drosophila lethal giant larvae tumor suppressor; interacts with SNARE protein Sec9p; SRO77 has a paralog, SRO7, that arose from the whole genome duplication	exocytosis|Golgi to plasma membrane transport	molecular_function	plasma membrane
YGR122W	YGR122W	YGR122W	hom	Verified	0.800885001387655	0.211599111926996	no	1024	0.24495906560225	880	NA	FF|FT	TRANSCRIPTION FROM RNA POL II			Protein that may be involved in pH regulation; probable ortholog of A. nidulans PalC, which is involved in pH regulation and binds to the ESCRT-III complex; null mutant does not properly process Rim101p and has decreased resistance to rapamycin; GFP-fusion protein is cytoplasmic; relative distribution to cytoplasm increases upon DNA replication stress	negative regulation of transcription from RNA polymerase II promoter|nuclear-transcribed mRNA catabolic process, non-stop decay	molecular_function	cytoplasm
YOR288C	YOR288C	MPD1	hom	Verified	0.798188366016787	0.212380593850557	no	1025	0.19291701973624	650	NA	FT		ENDOPLASMIC RETICULUM		Member of the protein disulfide isomerase (PDI) family; interacts with and inhibits the chaperone activity of Cne1p; MPD1 overexpression in a pdi1 null mutant suppresses defects in Pdi1p functions such as carboxypeptidase Y maturation	protein folding	protein disulfide oxidoreductase activity|protein disulfide isomerase activity	fungal-type vacuole
YHR198C	YHR198C	AIM18	hom	Verified	0.797751770228259	0.212507277261517	no	1026	0.213035551367491	751	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss	biological_process	molecular_function	mitochondrion
YPR079W	YPR079W	MRL1	hom	Verified	0.797464859343171	0.212590551864478	no	1027	0.198465224761126	670	NA	FT	PROTEIN LOCALIZATION|VACUOLAR TRANSPORT	GOLGI APPARATUS		Membrane protein; has similarity to mammalian mannose-6-phosphate receptors; possibly functions as a sorting receptor in the delivery of vacuolar hydrolases; protein abundance increases in response to DNA replication stress	vacuolar transport	signal sequence binding	late endosome|cytoplasm
YDR450W	YDR450W	RPS18A	hom	Verified	0.796835155815137	0.212773387304179	no	1028	0.225839212462804	763	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION	MITOCHONDRION	RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S18 and bacterial S13; RPS18A has a paralog, RPS18B, that arose from the whole genome duplication; protein increases in abundance and relocalizes from cytoplasm to nuclear foci upon DNA replication stress	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|cytoplasmic translation|rRNA export from nucleus	structural constituent of ribosome	cytosolic small ribosomal subunit|mitochondrion
YNR075W	YNR075W	COS10	hom	Verified	0.795818863073994	0.213068663098544	no	1029	0.18906615038372	689	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM		Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins	endocytosis	molecular_function	nuclear envelope|integral to membrane|endoplasmic reticulum|cytoplasm
YMR187C_p	YMR187C	YMR187C	hom	Uncharacterized	0.795602235483956	0.213131633420242	no	1030	0.210135918939831	687	NA					Putative protein of unknown function; YMR187C is not an essential gene	biological_process	molecular_function	integral to membrane
YDR439W	YDR439W	LRS4	hom	Verified	0.795407488371597	0.213188252687079	no	1031	0.236259730215052	826	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|CHROMOSOME SEGREGATION|GENE SILENCING	NUCLEUS|CHROMOSOME	KINETOCHORE	Nucleolar protein that forms a complex with Csm1p, and then Mam1p at kinetochores during meiosis I to mediate accurate homolog segregation; required for condensin recruitment to the replication fork barrier site and rDNA repeat segregation	rDNA condensation|chromatin silencing at rDNA|homologous chromosome segregation|protein localization to nucleolar rDNA repeats	molecular_function	nucleolus|nucleus|monopolin complex
YMR052C-A_d	YMR052C-A	YMR052C-A	hom	Dubious	0.795019684379954	0.213301025938293	no	1032	0.213287699898363	766	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YKL039W	YKL039W	PTM1	hom	Verified	0.794022756202599	0.21359109185478	no	1033	0.202408537209617	677	NA	FT		ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Protein of unknown function; copurifies with late Golgi vesicles containing the v-SNARE Tlg2p; PTM1 has a paralog, YHL017W, that arose from the whole genome duplication	biological_process	molecular_function	integral to membrane
YDL104C	YDL104C	QRI7	hom	Verified	0.79357421078615	0.213721675422417	no	1034	0.218682357467917	690	NA	FT	RNA PROCESSING|PROTEOLYSIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Highly conserved mitochondrial protein, essential for t6A modification of mitochondrial tRNAs that decode ANN codons; similar to Kae1p and E. coli YgjD, both of which are also required for tRNA t6A modification	mitochondrial tRNA threonylcarbamoyladenosine modification	molecular_function	mitochondrion
YKL001C	YKL001C	MET14	hom	Verified	0.793115944481934	0.213855137012651	no	1035	0.19657186793881	661	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Adenylylsulfate kinase, required for sulfate assimilation and involved in methionine metabolism	sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)|sulfur amino acid metabolic process	adenylylsulfate kinase activity	cytoplasm
YJR121W	YJR121W	ATP2	hom	Verified	0.792782520431057	0.213952271096175	no	1036	0.208587936664737	718	NA	FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS	MITOCHONDRION		Beta subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated	ATP synthesis coupled proton transport	hydrogen ion transporting ATP synthase activity, rotational mechanism|ATPase activity|proton-transporting ATPase activity, rotational mechanism	proton-transporting ATP synthase complex, catalytic core F(1)|mitochondrion|mitochondrial proton-transporting ATP synthase, catalytic core|integral to membrane
YNL252C	YNL252C	MRPL17	hom	Verified	0.792267975093786	0.214102220360493	no	1037	0.214416633306192	755	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YKR096W	YKR096W	ESL2	hom	Verified	0.790961279327038	0.214483293565412	no	1038	0.221331268377691	742	NA	FT		NUCLEUS		Protein of unknown function that interacts with Pex14p; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; predicted to contain a PINc domain	biological_process	molecular_function	ribosome|nucleus|cytoplasm
YMR135C	YMR135C	GID8	hom	Verified	0.790839646839948	0.214518785440259	no	1039	0.219036696229936	744	NA	FT	KETONE METABOLISM|CELL CYCLE|CARBOHYDRATE METABOLISM|PROTEOLYSIS	NUCLEUS		Subunit of GID Complex, binds strongly to central component Vid30p; GID Complex is involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; recruits Rmd5p, Fyv10 and Vid28p to GID Complex; contains LisH, CTLH, and CRA domains that mediate binding to Vid30p (LisH) and Rmd5p and Vid28p (CTLH and CRA); dosage-dependent regulator of START	negative regulation of gluconeogenesis|proteasomal ubiquitin-dependent protein catabolic process|traversing start control point of mitotic cell cycle	molecular_function	nucleus|GID complex|cytoplasm
YMR127C	YMR127C	SAS2	hom	Verified	0.790573634904703	0.214596418560771	no	1040	0.198536237901495	683	NA	FT	CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS|CHROMOSOME	HISTONE ACETYLTRANSFERASE	Histone acetyltransferase (HAT) catalytic subunit of the SAS complex (Sas2p-Sas4p-Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; member of the MYSTacetyltransferase family	histone acetylation|histone exchange|chromatin silencing at telomere	acetyltransferase activity|histone acetyltransferase activity	nuclear chromatin|SAS acetyltransferase complex|nuclear chromosome, telomeric region
YPL166W	YPL166W	ATG29	hom	Verified	0.790274534108209	0.214683727859979	no	1041	0.208396383937397	721	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|RESPONSE TO NUTRIENT LEVELS			Autophagy-specific protein; required for recruiting other ATG proteins to the pre-autophagosomal structure (PAS); interacts with Atg17p and localizas to the PAS in a manner interdependent with Atg17p and Cis1p; not conserved; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress	mitochondrion degradation|piecemeal microautophagy of nucleus|macroautophagy	molecular_function	pre-autophagosomal structure|cytoplasm
YOL027C	YOL027C	MDM38	hom	Verified	0.790106839535065	0.214732687932204	no	1042	0.218883281995936	745	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|TRANSLATION|ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS	MITOCHONDRION		Mitochondrial protein, forms a complex with Mba1p to facilitate recruitment of mRNA-specific translational activators to ribosomes; roles in protein export and K+/H+ exchange; human ortholog Letm1 implicated in Wolf-Hirschhorn syndrome	potassium ion transport|mitochondrial respiratory chain complex III biogenesis|cellular potassium ion homeostasis|proton transport|positive regulation of mitochondrial translation|mitochondrial respiratory chain complex IV biogenesis|protein insertion into mitochondrial membrane	ribosome binding	mitochondrion|mitochondrial inner membrane
YIL148W	YIL148W	RPL40A	hom	Verified	0.790045542548154	0.214750585806681	no	1043	0.221966134985614	724	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RESPONSE TO DNA DAMAGE|TRANSLATION	NUCLEUS	RIBOSOME	Ubiquitin-ribosomal 60S subunit protein L40A fusion protein; cleaved to yield ubiquitin and ribosomal protein L40A; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; homologous to mammalian ribosomal protein L40, no bacterial homolog; RPL40A has a paralog, RPL40B, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress	cytoplasmic translation|protein ubiquitination|ribosome biogenesis	structural constituent of ribosome|protein tag	cytosolic large ribosomal subunit
YGL121C	YGL121C	GPG1	hom	Verified	0.789648328533551	0.214866587824804	no	1044	0.187248548389123	664	NA	FT	SIGNALING			Proposed gamma subunit of the heterotrimeric G protein that interacts with the receptor Gpr1p; involved in regulation of pseudohyphal growth; requires Gpb1p or Gpb2p to interact with Gpa2p; overproduction causes prion curing	signal transduction|invasive growth in response to glucose limitation	signal transducer activity	cellular_component
YHR160C	YHR160C	PEX18	hom	Verified	0.787742964163384	0.215423534521403	no	1045	0.225814541986892	747	NA	FT	PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION			Peroxin required for targeting of peroxisomal matrix proteins containing PTS2; interacts with Pex7p; partially redundant with Pex21p	protein import into peroxisome matrix	protein binding	cytosol|peroxisome
YDR491C_d	YDR491C	YDR491C	hom	Dubious	0.786862329995863	0.215681230630329	no	1046	0.185537607696227	615	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YOR039W	YOR039W	CKB2	hom	Verified	0.785820311215625	0.21598638273578	no	1047	0.211945580283292	723	NA	FF|FT	RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION	NUCLEUS		Beta' regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerase	regulation of transcription from RNA polymerase I promoter|protein phosphorylation|regulation of transcription from RNA polymerase III promoter|response to DNA damage stimulus	protein serine/threonine kinase inhibitor activity|protein kinase regulator activity	protein kinase CK2 complex|UTP-C complex|CURI complex
YBR065C	YBR065C	ECM2	hom	Verified	0.78469580061837	0.216315972761146	no	1048	0.203116074197682	682	NA	FT	RNA PROCESSING	NUCLEUS		Pre-mRNA splicing factor, facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome, function may be regulated by Slu7p	mRNA splicing, via spliceosome	molecular_function	nucleus
YOR268C_p	YOR268C	YOR268C	hom	Uncharacterized	0.784687930181294	0.216318280583562	no	1049	0.17001090019927	554	NA					Putative protein of unknown function; sporulation is abnormal in homozygous diploid; YOR268C is not an essential gene	biological_process	molecular_function	cellular_component
YHR095W_d	YHR095W	YHR095W	hom	Dubious	0.784614504841645	0.216339811541488	no	1050	0.215853360619052	742	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YPL118W	YPL118W	MRP51	hom	Verified	0.782958496913037	0.216825742185532	no	1051	0.238174025650845	848	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the small subunit; MRP51 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequences	mitochondrial translational initiation|mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YCR032W	YCR032W	BPH1	hom	Verified	0.78293616014669	0.21683230088442	no	1052	0.219668591780096	755	NA	FT	PROTEIN LOCALIZATION|CELL WALL ORG/BIOGENESIS	MITOCHONDRION		Protein homologous to Chediak-Higashi syndrome and Beige proteins; both of which are implicated in disease syndromes in human and mouse, respectively, due to defective lysosomal trafficking; mutant phenotype and genetic interactions suggest a role in protein sorting	intracellular protein transport|fungal-type cell wall organization|response to pH	molecular_function	cytosol|mitochondrion|extrinsic to membrane
YPL208W	YPL208W	RKM1	hom	Verified	0.782816404438997	0.216867466463194	no	1053	0.214754081624939	724	NA	FT		NUCLEUS		SET-domain lysine-N-methyltransferase, catalyzes the formation of dimethyllysine residues on the large ribsomal subunit proteins L23a (Rpl23Ap and Rpl23Bp) and L18 (Rps18Ap and Rps18Bp)	peptidyl-lysine dimethylation	protein-lysine N-methyltransferase activity	nucleus|cytoplasm
YPL113C_p	YPL113C	YPL113C	hom	Uncharacterized	0.781560037627576	0.217236590077627	no	1054	0.186654318614706	656	NA	FT	OXIDATION-REDUCTION PROCESS			Glyoxylate reductase; acts on glyoxylate and hydroxypyruvate substrates; YPL113C is not an essential gene	metabolic process	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	cellular_component
YLR199C	YLR199C	PBA1	hom	Verified	0.78069104524071	0.217492114313864	no	1055	0.17754768764885	605	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS			Protein involved in 20S proteasome assembly; forms a heterodimer with Add66p that binds to proteasome precursors; similar to human PAC1 constituent of the PAC1-PAC2 complex involved in proteasome assembly	proteasome assembly	molecular_function	cytoplasm
YER044C	YER044C	ERG28	hom	Verified	0.780673984793889	0.217497132615742	no	1056	0.228072953894005	803	NA	FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Endoplasmic reticulum membrane protein, may facilitate protein-protein interactions between the Erg26p dehydrogenase and the Erg27p 3-ketoreductase and/or tether these enzymes to the ER, also interacts with Erg6p	ergosterol biosynthetic process	protein binding, bridging	endoplasmic reticulum membrane
YJL089W	YJL089W	SIP4	hom	Verified	0.779719684714399	0.217777944802736	no	1057	0.227250218192204	802	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		C6 zinc cluster transcriptional activator that binds to the carbon source-responsive element (CSRE) of gluconeogenic genes; involved in the positive regulation of gluconeogenesis; regulated by Snf1p protein kinase; localized to the nucleus	positive regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source|positive regulation of gluconeogenesis|positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter|Unknown	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YDR130C	YDR130C	FIN1	hom	Verified	0.779101131440696	0.217960071847238	no	1058	0.220208025725392	713	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME|CYTOSKELETON	KINETOCHORE	Spindle pole body-related intermediate filament protein; forms cell cycle-specific filaments between spindle pole bodies in dividing cells; localizes to poles and microtubules of spindle during anaphase and contributes to spindle stability; involved in Glc7p localization and regulation; relative distribution to the nucleus increases upon DNA replication stress	intermediate filament cytoskeleton organization|mitotic cell cycle spindle checkpoint|mitotic spindle stabilization|mitotic sister chromatid segregation	microtubule binding|structural constituent of cytoskeleton	spindle microtubule|condensed nuclear chromosome kinetochore|intermediate filament|nucleus|spindle pole body|astral microtubule|spindle
YOR330C	YOR330C	MIP1	hom	Verified	0.778349448311127	0.218181515857873	no	1059	0.18869658715401	625	NA	FT	MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit	mitochondrial DNA replication	3'-5' exonuclease activity|DNA-directed DNA polymerase activity	mitochondrion
YAL048C	YAL048C	GEM1	hom	Verified	0.777718423779639	0.218367514206695	no	1060	0.198792914749108	719	NA	FT	SIGNALING|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION		Outer mitochondrial membrane GTPase, subunit of the ERMES complex; potential regulatory subunit of the ERMES complex that links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth; cells lacking Gem1p contain collapsed, globular, or grape-like mitochondria; ortholog of metazoan Miro GTPases	mitochondrion inheritance|regulation of mitochondrion organization|phospholipid homeostasis	GTPase activity|calcium ion binding	mitochondrial outer membrane|ERMES complex|mitochondrion
YBR073W	YBR073W	RDH54	hom	Verified	0.77768292092911	0.218377981602752	no	1061	0.243411169498401	856	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION	NUCLEUS		DNA-dependent ATPase; stimulates strand exchange by modifying the topology of double-stranded DNA; involved in recombinational repair of DNA double-strand breaks during mitosis and meiosis; proposed to be involved in crossover interference; interacts with Dmc1p; stimulates Dmc1p and Rad51p	DNA geometric change|heteroduplex formation|meiotic sister chromatid segregation|reciprocal meiotic recombination|double-strand break repair via break-induced replication	DNA-dependent ATPase activity|DNA translocase activity	nucleus
YEL059C-A	YEL059C-A	SOM1	hom	Verified	0.777390723601796	0.218464141863822	no	1062	0.204899001484965	688	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs	proteolysis|mitochondrial respiratory chain complex assembly	endopeptidase activity	mitochondrial inner membrane peptidase complex|mitochondrial inner membrane
YIR024C	YIR024C	YIR024C	hom	Verified	0.776870459767785	0.218617600573737	no	1063	0.23215481394669	768	NA	FT		MITOCHONDRION		Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; interacts with Arh1p, a mitochondrial oxidoreductase; deletion mutant has a respiratory growth defect	biological_process	molecular_function	mitochondrion
YCR073C	YCR073C	SSK22	hom	Verified	0.77333348077366	0.219662523050607	no	1064	0.201560512589685	677	NA	FT	SIGNALING|PROTEIN PHOSPHORYLATION			MAP kinase kinase kinase of the HOG1 mitogen-activated signaling pathway; functionally redundant with, and homologous to, Ssk2p; interacts with and is activated by Ssk1p; phosphorylates Pbs2p	MAPK cascade involved in osmosensory signaling pathway|protein phosphorylation	protein kinase activity|MAP kinase kinase kinase activity	cellular_component
YOL056W	YOL056W	GPM3	hom	Verified	0.772621094154432	0.21987332841906	no	1065	0.217078795541017	756	NA	FT	CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY			Homolog of Gpm1p phosphoglycerate mutase, which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event	biological_process	phosphoglycerate mutase activity|molecular_function	cytosol
YNR070W_p	YNR070W	PDR18	hom	Uncharacterized	0.772263595490324	0.219979161114465	no	1066	0.198877593460465	698	NA	FT	NUCLEOTIDE METABOLISM	MITOCHONDRION		Putative transporter of the ATP-binding cassette (ABC) family, implicated in pleiotropic drug resistance; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	transport	ATPase activity, coupled to transmembrane movement of substances	mitochondrion|integral to membrane|membrane
YNR050C	YNR050C	LYS9	hom	Verified	0.770412159669364	0.220527721345825	no	1067	0.230224709705528	772	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS			Saccharopine dehydrogenase (NADP+, L-glutamate-forming); catalyzes the formation of saccharopine from alpha-aminoadipate 6-semialdehyde, the seventh step in lysine biosynthesis pathway; exhibits genetic and physical interactions with TRM112	lysine biosynthetic process via aminoadipic acid	saccharopine dehydrogenase (NADP+, L-glutamate-forming) activity	cytoplasm
YOL072W	YOL072W	THP1	hom	Verified	0.769977600302312	0.220656590032791	no	1068	0.278764262139657	970	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|RNA PROCESSING|RESPONSE TO DNA DAMAGE|CELL DIVISION|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	Nuclear pore-associated protein; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; contains a PAM domain implicated in protein-protein binding	mRNA export from nucleus|mRNA 3'-end processing|transcription-coupled nucleotide-excision repair|cellular bud site selection|nuclear retention of pre-mRNA at the site of transcription|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|transcription elongation from RNA polymerase II promoter	double-stranded DNA binding|RNA binding	nuclear envelope|nucleus|transcription export complex 2|nuclear pore
YKL091C	YKL091C	YKL091C	hom	Verified	0.769529111418209	0.220789634743907	no	1069	0.225716053211035	789	NA	FT		NUCLEUS		Putative homolog of Sec14p, which is a phosphatidylinositol/phosphatidylcholine transfer protein involved in lipid metabolism; localizes to the nucleus; contains a CRAL/TRIO domain and binds several lipids in a large-scale study	biological_process	phosphatidylcholine binding|phosphatidylinositol transporter activity|phosphatidylinositol binding|phosphatidylcholine transporter activity	nucleus
YNR005C_d	YNR005C	YNR005C	hom	Dubious	0.768912651574117	0.220972583165383	no	1070	0.238801727827156	851	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDR241W_d	YDR241W	BUD26	hom	Dubious	0.768571494724368	0.221073866473279	no	1071	0.232207341991106	800	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 1% of ORF overlaps the verified gene SNU56; diploid mutant displays a weak budding pattern phenotype in a systematic assay	Unknown	Unknown	Unknown
YDL175C	YDL175C	AIR2	hom	Verified	0.768232156970984	0.221174636072578	no	1072	0.230337390649794	775	NA	FT	RNA PROCESSING	NUCLEUS		RNA-binding subunit of the TRAMP nuclear RNA surveillance complex; involved in nuclear RNA processing and degradation; involved in TRAMP complex assembly as a bridge between Mtr4p and Trf4p; stimulates the poly(A) polymerase activity of Pap2p in vitro; has 5 zinc knuckle motifs; AIR2 has a paralog, AIR1, that arose from the whole genome duplication	nuclear polyadenylation-dependent CUT catabolic process|nuclear mRNA surveillance of mRNA 3'-end processing|nuclear polyadenylation-dependent tRNA catabolic process|nuclear polyadenylation-dependent snoRNA catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|nuclear polyadenylation-dependent snRNA catabolic process|ncRNA polyadenylation|tRNA modification	polynucleotide adenylyltransferase activity|RNA binding|protein binding, bridging	nucleolus|TRAMP complex
YKL098W	YKL098W	MTC2	hom	Verified	0.767845905115692	0.221289369236574	no	1073	0.261331993548092	907	NA					Protein of unknown function; mtc2 is synthetically sick with cdc13-1	biological_process	molecular_function	cellular_component
YHL001W	YHL001W	RPL14B	hom	Verified	0.767572600224823	0.221370572927882	no	1074	0.21243925124845	704	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L14B; homologous to mammalian ribosomal protein L14, no bacterial homolog; RPL14B has a paralog, RPL14A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress	cytoplasmic translation	structural constituent of ribosome|RNA binding	cytosolic large ribosomal subunit
YOR291W	YOR291W	YPK9	hom	Verified	0.767237214226092	0.221470245289451	no	1075	0.202986534244273	655	NA	FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS			Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome	biological_process	molecular_function	fungal-type vacuole membrane|integral to membrane
YKL175W	YKL175W	ZRT3	hom	Verified	0.766527105770319	0.221681364942214	no	1076	0.203815610500632	643	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Vacuolar membrane zinc transporter, transports zinc from storage in the vacuole to the cytoplasm when needed; transcription is induced under conditions of zinc deficiency	cellular zinc ion homeostasis|zinc ion transport	zinc ion transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane
YDL224C	YDL224C	WHI4	hom	Verified	0.766170897113121	0.221787311282635	no	1077	0.177804001975378	581	NA					Putative RNA binding protein; regulates the cell size requirement for passage through Start and commitment to cell division; WHI4 has a paralog, WHI3, that arose from the whole genome duplication	regulation of cell size	RNA binding	cytoplasm
YOL082W	YOL082W	ATG19	hom	Verified	0.765900655115534	0.221867708044923	no	1078	0.192646842802604	606	NA	FT	PROTEIN LOCALIZATION|PROTEOLYSIS|VACUOLAR TRANSPORT			Receptor protein for the cytoplasm-to-vacuole targeting (Cvt) pathway; delivers cargo proteins aminopeptidase I (Ape1p) and alpha-mannosidase (Ams1p) to the phagophore assembly site for packaging into Cvt vesicles	vesicle organization|ER-associated protein catabolic process|protein processing|protein complex localization|CVT pathway	protein binding, bridging	pre-autophagosomal structure|cytoplasm|CVT complex|extrinsic to membrane
YLR165C	YLR165C	PUS5	hom	Verified	0.763746411530545	0.222509188556576	no	1079	0.229606891879027	789	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	MITOCHONDRION		Pseudouridine synthase, catalyzes only the formation of pseudouridine (Psi)-2819 in mitochondrial 21S rRNA; not essential for viability	rRNA modification|pseudouridine synthesis	pseudouridylate synthase activity	mitochondrion
YPL246C	YPL246C	RBD2	hom	Verified	0.763650683105306	0.222537718637733	no	1080	0.206251850289817	689	NA	FT	PROTEOLYSIS	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Possible rhomboid protease, has similarity to eukaryotic rhomboid proteases including Pcp1p	biological_process	molecular_function	COPI-coated vesicle|integral to membrane|Golgi apparatus
YEL071W	YEL071W	DLD3	hom	Verified	0.763601219964281	0.222552461026536	no	1081	0.215951085219034	706	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS			D-lactate dehydrogenase, part of the retrograde regulon which consists of genes whose expression is stimulated by damage to mitochondria and reduced in cells grown with glutamate as the sole nitrogen source, located in the cytoplasm	lactate metabolic process|filamentous growth	D-lactate dehydrogenase (cytochrome) activity	cytoplasm
YGL140C_p	YGL140C	YGL140C	hom	Uncharacterized	0.762988601444676	0.222735096884817	no	1082	0.173927407821257	576	NA					Putative protein of unknown function; non-essential gene; contains multiple predicted transmembrane domains	biological_process	molecular_function	integral to membrane
YGL032C	YGL032C	AGA2	hom	Verified	0.762451438004002	0.222895308086374	no	1083	0.216695766372753	734	NA					Adhesion subunit of a-agglutinin of a-cells, C-terminal sequence acts as a ligand for alpha-agglutinin (Sag1p) during agglutination, modified with O-linked oligomannosyl chains, linked to anchorage subunit Aga1p via two disulfide bonds	agglutination involved in conjugation with cellular fusion	cell adhesion molecule binding	fungal-type cell wall
YAL054C	YAL054C	ACS1	hom	Verified	0.760713390509997	0.223414137506751	no	1084	0.203197115679883	672	NA	FT	KETONE METABOLISM|CHROMATIN ORGANIZATION|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	NUCLEUS|ENDOPLASMIC RETICULUM|MITOCHONDRION		Acetyl-coA synthetase isoform which, along with Acs2p, is the nuclear source of acetyl-coA for histone acetylation; expressed during growth on nonfermentable carbon sources and under aerobic conditions	acetate fermentation|histone acetylation|acetyl-CoA biosynthetic process	acetate-CoA ligase activity|acid-ammonia (or amide) ligase activity	cytosol|mitochondrion|integral to membrane
YJL013C	YJL013C	MAD3	hom	Verified	0.760259687115303	0.223549686784036	no	1085	0.20371740930254	705	NA	FT	CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION	NUCLEUS		Subunit of the spindle-assembly checkpoint complex, which delays anaphase onset in cells with defects in mitotic spindle assembly; pseudosubstrate inhibitor of APC(Cdc20), the anaphase promoting complex involved in securin (Pds1p) turnover	distributive segregation|mitotic cell cycle spindle assembly checkpoint|mitotic cell cycle G2/M transition decatenation checkpoint	molecular_function	mitotic checkpoint complex
YHL038C	YHL038C	CBP2	hom	Verified	0.758254146474511	0.224149425935207	no	1086	0.180559599244964	611	NA	FT	RNA PROCESSING	MITOCHONDRION		Required for splicing of the group I intron bI5 of the COB pre-mRNA; nuclear-encoded mitochondrial protein that binds to the RNA to promote splicing; also involved in but not essential for splicing of the COB bI2 intron and the intron in the 21S rRNA gene	Group I intron splicing	RNA binding	mitochondrion
YOR040W	YOR040W	GLO4	hom	Verified	0.758168099637104	0.224175177906574	no	1087	0.203304814325052	656	NA	FT	KETONE METABOLISM|CARBOHYDRATE METABOLISM	MITOCHONDRION		Mitochondrial glyoxalase II, catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate	cellular carbohydrate metabolic process|methylglyoxal catabolic process to D-lactate	hydroxyacylglutathione hydrolase activity	mitochondrion|mitochondrial matrix
YNL073W	YNL073W	MSK1	hom	Verified	0.757777776156705	0.224292014440162	no	1088	0.233580994411466	803	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION|RNA LOCALIZATION	MITOCHONDRION		Mitochondrial lysine-tRNA synthetase, required for import of both aminoacylated and deacylated forms of tRNA(Lys) into mitochondria and for aminoacylation of mitochondrially encoded tRNA(Lys)	tRNA import into mitochondrion|lysyl-tRNA aminoacylation|mitochondrial lysyl-tRNA aminoacylation|mitochondrial translation	lysine-tRNA ligase activity	mitochondrion
YOR378W_p	YOR378W	YOR378W	hom	Uncharacterized	0.757168047270839	0.224474595322032	no	1089	0.20413883940729	682	NA	FT		PLASMA MEMBRANE		Putative paralog of ATR1, but not required for boron tolerance; member of the DHA2 family of drug:H+ antiporters; YOR378W is not an essential gene	biological_process	molecular_function	integral to membrane
YLR453C	YLR453C	RIF2	hom	Verified	0.756901559074578	0.224554420627861	no	1090	0.216372874471612	788	NA	FT		NUCLEUS|CHROMOSOME		Protein that binds to the Rap1p C-terminus and acts synergistically with Rif1p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation	telomere capping|telomere maintenance via telomerase	telomeric DNA binding	nuclear telomere cap complex
YLL032C	YLL032C	YLL032C	hom	Verified	0.755502942435492	0.224973633744426	no	1091	0.204503141704236	686	NA					Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene	biological_process	molecular_function	ribosome|cytoplasm
YEL068C_p	YEL068C	YEL068C	hom	Uncharacterized	0.755169225302359	0.225073725657278	no	1092	0.18476751850217	624	NA					Protein of unknown function; expressed at both mRNA and protein levels	biological_process	molecular_function	cellular_component
YFL015C_d	YFL015C	YFL015C	hom	Dubious	0.754545054046258	0.225261001305984	no	1093	0.215354771743389	712	NA					Dubious open reading frame unlikely to encode a protein; partially overlaps dubious ORF YFL015W-A; YFL015C is not an essential gene	Unknown	Unknown	Unknown
YDL203C	YDL203C	ACK1	hom	Verified	0.7542481978441	0.225350100668908	no	1094	0.223475858940037	719	NA	FT	SIGNALING|CELL WALL ORG/BIOGENESIS	MITOCHONDRION		Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria	fungal-type cell wall organization|positive regulation of signal transduction	molecular_function	mitochondrion
YNL279W	YNL279W	PRM1	hom	Verified	0.754226460408199	0.225356625795952	no	1095	0.228818125461417	806	NA	FT	MEMBRANE ORGANIZATION	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Pheromone-regulated multispanning membrane protein involved in membrane fusion during mating; predicted to have 5 transmembrane segments and a coiled coil domain; localizes to the shmoo tip; regulated by Ste12p	plasma membrane fusion involved in cytogamy|response to pheromone	molecular_function	integral to membrane|mating projection tip
YLR381W	YLR381W	CTF3	hom	Verified	0.753376242934453	0.225611927342788	no	1096	0.199164242345479	690	NA	FT	CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME	KINETOCHORE	Outer kinetochore protein that forms a complex with Mcm16p and Mcm22p; may bind the kinetochore to spindle microtubules; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-I and fission yeast mis6	chromosome segregation|DNA replication initiation|establishment of mitotic sister chromatid cohesion	molecular_function	condensed nuclear chromosome kinetochore
YHR060W	YHR060W	VMA22	hom	Verified	0.751893673153636	0.226057501609194	no	1097	0.230843909420025	782	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|ION HOMEOSTASIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Peripheral membrane protein that is required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the yeast endoplasmic reticulum (ER)	vacuolar proton-transporting V-type ATPase complex assembly|vacuolar acidification	unfolded protein binding	extrinsic to endoplasmic reticulum membrane
YGR001C_p	YGR001C	YGR001C	hom	Uncharacterized	0.751333594498468	0.226225958043013	no	1098	0.196394125627924	654	NA					Putative protein of unknown function with similarity to methyltransferase family members; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; required for replication of Brome mosaic virus in S. cerevisiae	biological_process	methyltransferase activity	cytoplasm
YPL029W	YPL029W	SUV3	hom	Verified	0.750193053216583	0.226569221035836	no	1099	0.282909541481377	963	NA	FF|FT	RNA PROCESSING|MITOCHONDRION ORGANIZATION	MITOCHONDRION|CHROMOSOME		ATP-dependent RNA helicase, component of the mitochondrial degradosome along with the RNase Dss1p; the degradosome associates with the ribosome and mediates RNA turnover; also required during splicing of the COX1 AI5_beta intron	mitochondrial DNA replication|mitochondrial RNA catabolic process|Group I intron splicing	exoribonuclease II activity|ATP-dependent RNA helicase activity	mitochondrion|mitochondrial chromosome|mitochondrial degradosome
YHR051W	YHR051W	COX6	hom	Verified	0.749108622689748	0.226895869161769	no	1100	0.221810037344799	783	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Subunit VI of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; expression is regulated by oxygen levels	mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity	mitochondrion|integral to membrane|mitochondrial respiratory chain complex IV
YCR085W_d	YCR085W	YCR085W	hom	Dubious	0.748585929831939	0.227053407581261	no	1101	0.219688498482629	763	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YIR002C	YIR002C	MPH1	hom	Verified	0.748429428629434	0.227100588676469	no	1102	0.227755976412388	786	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		3'-5' DNA helicase involved in error-free bypass of DNA lesions; binds to flap DNA in an error-free bypass pathway and stimulates the activity of Rad27p and Dna2p; also involved in interstrand cross-link repair mutations confer a mutator phenotype; similarity to FANCM, a human Fanconi anemia complementation group protein that along with the MHF complex is involved in stabilizing and remodeling blocked replication forks; member of the SF2 DExD/H superfamily of helicases	negative regulation of strand invasion|recombinational repair|DNA replication, Okazaki fragment processing	flap-structured DNA binding|3'-5' DNA helicase activity	nucleus
YML001W	YML001W	YPT7	hom	Verified	0.746664840428411	0.2276329490632	no	1103	0.212165209770897	740	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING|VACUOLAR TRANSPORT	MITOCHONDRION		Rab family GTPase; GTP-binding protein of the rab family; required for homotypic fusion event in vacuole inheritance, for endosome-endosome fusion; interacts with the cargo selection/retromer complex for retrograde sorting; similar to mammalian Rab7	regulation of vacuole fusion, non-autophagic|piecemeal microautophagy of nucleus|vacuole inheritance|Golgi to vacuole transport|vesicle-mediated transport|endocytosis	GTPase activity	mitochondrial outer membrane|fungal-type vacuole
YGL240W	YGL240W	DOC1	hom	Verified	0.745760677267314	0.227905998957915	no	1104	0.237703054399844	827	NA	FT	CELL CYCLE|CHROMATIN ORGANIZATION|CELL DIVISION|PROTEOLYSIS	NUCLEUS|MITOCHONDRION	UBIQUITIN LIGASE COMPLEX	Processivity factor required for the ubiquitination activity of the anaphase promoting complex (APC), mediates the activity of the APC by contributing to substrate recognition; involved in cyclin proteolysis; contains a conserved DOC1 homology domain	activation of mitotic anaphase-promoting complex activity|chromatin assembly|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cyclin catabolic process	enzyme regulator activity|mitotic anaphase-promoting complex activity	mitochondrion|anaphase-promoting complex
YPR083W	YPR083W	MDM36	hom	Verified	0.743744030150107	0.228515673285575	no	1105	0.236101387570373	761	NA	FT	MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial protein required for normal mitochondrial morphology and inheritance; proposed involvement in the formation of Dnm1p and Num1p-containing cortical anchor complexes that promote mitochondrial fission	mitochondrial fission|mitochondrion organization	molecular_function	mitochondrion|cytoplasm
YDR467C_d	YDR467C	YDR467C	hom	Dubious	0.742959797826394	0.228753010204162	no	1106	0.234676227338058	781	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YOL096C	YOL096C	COQ3	hom	Verified	0.742624993540249	0.228854376164081	no	1107	0.227065019576319	805	NA	FT	KETONE METABOLISM|COFACTOR METABOLISM	MITOCHONDRION		O-methyltransferase, catalyzes two different O-methylation steps in ubiquinone (Coenzyme Q) biosynthesis; component of a mitochondrial ubiquinone-synthesizing complex; phosphoprotein	ubiquinone biosynthetic process	hexaprenyldihydroxybenzoate methyltransferase activity	mitochondrion|mitochondrial inner membrane|extrinsic to membrane
YJR015W_p	YJR015W	YJR015W	hom	Uncharacterized	0.742041170065876	0.229031195927053	no	1108	0.21278703543113	711	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Putative protein of unknown function; localizes to the endoplasmic reticulum and cytoplasm; predicted to encode a membrane transporter based on phylogenetic analysis; YJR015W is a non-essential gene	biological_process	molecular_function	integral to membrane|endoplasmic reticulum|cytoplasm
YBR283C	YBR283C	SSH1	hom	Verified	0.740973944371939	0.229354619381027	no	1109	0.208450985467902	676	NA	FT	PROTEIN LOCALIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Subunit of the Ssh1 translocon complex; Sec61p homolog involved in co-translational pathway of protein translocation; not essential	SRP-dependent cotranslational protein targeting to membrane	protein transmembrane transporter activity|signal sequence binding	integral to membrane|Ssh1 translocon complex
YGR247W	YGR247W	CPD1	hom	Verified	0.739041717051019	0.229940833005745	no	1110	0.224240097868279	772	NA	FT	NUCLEOTIDE METABOLISM	GOLGI APPARATUS		Cyclic nucleotide phosphodiesterase; hydrolyzes ADP-ribose 1'', 2''-cyclic phosphate to ADP-ribose 1''-phosphate; may have a role in tRNA splicing; no detectable phenotype is conferred by null mutation or by overexpression; protein abundance increases in response to DNA replication stress	cyclic nucleotide metabolic process	2',3'-cyclic-nucleotide 3'-phosphodiesterase activity	clathrin-coated vesicle
YNL248C	YNL248C	RPA49	hom	Verified	0.73897589605995	0.229960817031843	no	1111	0.215805553908891	737	NA	FT		NUCLEUS		RNA polymerase I subunit A49	transcription elongation from RNA polymerase I promoter|transcription of nuclear large rRNA transcript from RNA polymerase I promoter|regulation of cell size	molecular_function	DNA-directed RNA polymerase I complex
YLR138W	YLR138W	NHA1	hom	Verified	0.73848398590622	0.230110197508348	no	1112	0.21644465818763	735	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Na+/H+ antiporter involved in sodium and potassium efflux through the plasma membrane; required for alkali cation tolerance at acidic pH	cellular potassium ion homeostasis|cellular monovalent inorganic cation homeostasis|response to osmotic stress	cation:cation antiporter activity|sodium:hydrogen antiporter activity	membrane raft|integral to membrane|plasma membrane
YBL054W	YBL054W	TOD6	hom	Verified	0.737773059352253	0.230326183537144	no	1113	0.222891108845158	758	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS|CHROMOSOME		PAC motif binding protein involved in rRNA and ribosome biogenesis; subunit of the RPD3L histone deacetylase complex; Myb-like HTH transcription factor; hypophosphorylated by rapamycin treatment in a Sch9p-dependent manner; TOD6 has a paralog, DOT6, that arose from the whole genome duplication	regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding	Rpd3L-Expanded complex|nucleus|Rpd3L complex|cytoplasm
YDL040C	YDL040C	NAT1	hom	Verified	0.736496208184452	0.230714387159772	no	1114	0.22048197375707	742	NA	FT		MITOCHONDRION	RIBOSOME	Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing	N-terminal protein amino acid acetylation	peptide alpha-N-acetyltransferase activity	mitochondrion|NatA complex|cytosolic ribosome
YML022W	YML022W	APT1	hom	Verified	0.736264629356155	0.23078483367212	no	1115	0.184468784832909	628	NA	FT	NUCLEOTIDE METABOLISM	NUCLEUS		Adenine phosphoribosyltransferase; catalyzes the formation of AMP from adenine and 5-phosphoribosylpyrophosphate; involved in the salvage pathway of purine nucleotide biosynthesis; APT1 has a paralog, APT2, that arose from the whole genome duplication	AMP biosynthetic process|adenine salvage	adenine phosphoribosyltransferase activity	nucleus|cytoplasm
YFR012W	YFR012W	DCV1	hom	Verified	0.734355313404724	0.23136610714312	no	1116	0.213065396034349	733	NA					Protein of unknown function; deletion mutant shows strong genetic interaction with cdc28-as1 mutant in the presence of 1-NM-PP1; DCV1 has a paralog, YOL019W, that arose from the whole genome duplication	biological_process	molecular_function	integral to membrane
YCL055W	YCL055W	KAR4	hom	Verified	0.734064666722494	0.231454663370642	no	1117	0.211762413829214	746	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE	NUCLEUS		Transcription factor required for gene regulation in response to pheromones; also required during meiosis; exists in two forms, a slower-migrating form more abundant during vegetative growth and a faster-migrating form induced by pheromone	karyogamy involved in conjugation with cellular fusion|meiosis|negative regulation of transcription from RNA polymerase II promoter by pheromones|positive regulation of transcription from RNA polymerase II promoter by pheromones|G1 phase of mitotic cell cycle	sequence-specific DNA binding transcription factor activity	nucleus|cytoplasm
YDL154W	YDL154W	MSH5	hom	Verified	0.732663479686152	0.231881851729114	no	1118	0.214695482195704	732	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME		Protein of the MutS family, forms a dimer with Msh4p that facilitates crossovers between homologs during meiosis; msh5-Y823H mutation confers tolerance to DNA alkylating agents; homologs present in C. elegans and humans	reciprocal meiotic recombination	molecular_function	nucleus
YLR200W	YLR200W	YKE2	hom	Verified	0.731334352436385	0.232287476299659	no	1119	0.273331716520451	959	NA	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS	NUCLEUS		Subunit of the heterohexameric Gim/prefoldin protein complex involved in the folding of alpha-tubulin, beta-tubulin, and actin	protein folding|tubulin complex assembly	tubulin binding	prefoldin complex|cytoplasm
YER039C-A_p	YER039C-A	YER039C-A	hom	Uncharacterized	0.729781169807443	0.232761978147584	no	1120	0.228807825608899	778	NA					Putative protein of unknown function; YER039C-A is not an essential gene	biological_process	molecular_function	integral to membrane
YJL063C	YJL063C	MRPL8	hom	Verified	0.728978607835102	0.23300737409532	no	1121	0.253768421363107	908	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit	mitochondrial genome maintenance|mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YNL241C	YNL241C	ZWF1	hom	Verified	0.728917402706147	0.233026094420882	no	1122	0.218228358935978	761	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS			Glucose-6-phosphate dehydrogenase (G6PD); catalyzes the first step of the pentose phosphate pathway; involved in adapting to oxidatve stress; homolog of the human G6PD which is deficient in patients with hemolytic anemia; protein abundance increases in response to DNA replication stress	NADPH regeneration|response to hydrogen peroxide|pentose-phosphate shunt, oxidative branch|carbon catabolite repression of transcription	glucose-6-phosphate dehydrogenase activity	cytoplasm
YHL025W	YHL025W	SNF6	hom	Verified	0.728026779761702	0.233298596655061	no	1123	0.245935134195018	780	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|CARBOHYDRATE METABOLISM	NUCLEUS	RSC COMPLEX	Subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; functions interdependently in transcriptional activation with Snf2p and Snf5p; relocates to the cytosol under hypoxic conditions	sucrose catabolic process|nucleotide-excision repair|chromatin remodeling|positive regulation of transcription from RNA polymerase II promoter	molecular_function	SWI/SNF complex|nucleus
YCR076C	YCR076C	FUB1	hom	Verified	0.72771132169002	0.233395159164579	no	1124	0.277232244504219	926	NA					Putative protein of unknown function; interacts physically with multiple subunits of the 20S proteasome and genetically with genes encoding 20S core particle and 19S regulatory particle subunits; exhibits boundary activity which blocks the propagation of heterochromatic silencing; contains a PI31 proteasome regulator domain and sequence similarity with human PSMF1, a proteasome inhibitor; not an essential gene	biological_process	proteasome binding	cellular_component
YBR051W_d	YBR051W	YBR051W	hom	Dubious	0.725812751444357	0.233976784360279	no	1125	0.230092791297916	792	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partiallly overlaps the REG2/YBR050C regulatory subunit of the Glc7p type-1 protein phosphatase	Unknown	Unknown	Unknown
YKL053C-A	YKL053C-A	MDM35	hom	Verified	0.725097003470929	0.234196261302386	no	1126	0.247746421009263	848	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION	NUCLEUS|MITOCHONDRION		Mitochondrial intermembrane space protein; mutation affects mitochondrial distribution and morphology; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress	mitochondrion organization|mitochondrial respiratory chain complex assembly	molecular_function	nucleus|cytoplasm|mitochondrial intermembrane space
YIL132C	YIL132C	CSM2	hom	Verified	0.724984760138626	0.234230689931187	no	1127	0.200346852345868	694	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION	NUCLEUS		Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function; structural analysis reveals a similar DNA-binding region in both Psy3p and Csm2p and that both regions work together to form a single DNA binding site; required for accurate chromosome segregation during meiosis	meiotic chromosome segregation|recombinational repair|maintenance of rDNA|error-free translesion synthesis	molecular_function	nucleus|Shu complex|cytoplasm
YGR142W	YGR142W	BTN2	hom	Verified	0.724432592620118	0.234400098201756	no	1128	0.233019276805947	792	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|ION HOMEOSTASIS|ION HOMEOSTASIS			v-SNARE binding protein; facilitates specific protein retrieval from a late endosome to the Golgi; modulates arginine uptake, possible role in mediating pH homeostasis between the vacuole and plasma membrane H(+)-ATPase; BTN2 has a paralog, CUR1, that arose from the whole genome duplication	intracellular protein transport|amino acid transport|retrograde transport, endosome to Golgi|regulation of pH	SNARE binding	cytosol|late endosome|perinuclear region of cytoplasm
YDL089W	YDL089W	NUR1	hom	Verified	0.723789898672931	0.234597365873266	no	1129	0.245547307423352	850	NA	FT		ENDOMEMBRANE SYSTEM|NUCLEUS		Protein of unknown function; interacts with Csm1p, Lrs4p; required for rDNA repeat stability; null mutant causes increase in unequal sister-chromatid exchange; GFP-fusion protein localizes to the nuclear periphery, possible Cdc28p substrate	maintenance of rDNA	molecular_function	nuclear periphery
YLR262C	YLR262C	YPT6	hom	Verified	0.722371018851621	0.235033200002269	no	1130	0.330062360948201	1115	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING	GOLGI APPARATUS|PLASMA MEMBRANE		Rab family GTPase, Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity to the human GTPase, Rab6	intracellular protein transport|retrograde transport, endosome to Golgi	GTPase activity	Golgi apparatus
YMR054W	YMR054W	STV1	hom	Verified	0.720926853980646	0.235477259839081	no	1131	0.238739905643342	835	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Subunit a of the vacuolar-ATPase V0 domain, one of two isoforms (Stv1p and Vph1p); Stv1p is located in V-ATPase complexes of the Golgi and endosomes while Vph1p is located in V-ATPase complexes of the vacuole	vacuolar acidification	proton-transporting ATPase activity, rotational mechanism	vacuolar proton-transporting V-type ATPase, V0 domain|late endosome|integral to membrane|Golgi apparatus
YJL129C	YJL129C	TRK1	hom	Verified	0.719711914891171	0.235851194340359	no	1132	0.280585549336137	964	NA	FF|FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Component of the Trk1p-Trk2p potassium transport system; 180 kDa high affinity potassium transporter; phosphorylated in vivo and interacts physically with the phosphatase Ppz1p, suggesting Trk1p acitivy is regulated by phosphorylation; TRK1 has a paralog, TRK2, that arose from the whole genome duplication	cellular potassium ion homeostasis	potassium ion transmembrane transporter activity	membrane raft|integral to membrane|plasma membrane
YFL031W	YFL031W	HAC1	hom	Verified	0.718176509626628	0.23632422995001	no	1133	0.216638900654365	731	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|SIGNALING	NUCLEUS		Basic leucine zipper (bZIP) transcription factor (ATF/CREB1 homolog); regulates the unfolded protein response, via UPRE binding, and membrane biogenesis; ER stress-induced splicing pathway facilitates efficient Hac1p synthesis; protein abundance increases in response to DNA replication stress	endoplasmic reticulum unfolded protein response|positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response|negative regulation of transcription from RNA polymerase II promoter during meiosis|positive regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity	nucleus
YER087C-A_d	YER087C-A	YER087C-A	hom	Dubious	0.717019593998782	0.236681003318874	no	1134	0.224615188129393	746	NA					Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; overlaps the uncharacterized gene YER087W, a putative tRNA synthetase	Unknown	Unknown	Unknown
YGR076C	YGR076C	MRPL25	hom	Verified	0.715411583653336	0.237177378429807	no	1135	0.253650856461755	877	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit; mutation confers increased replicative lifespan	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YOR150W	YOR150W	MRPL23	hom	Verified	0.714085248936016	0.237587233392208	no	1136	0.273186633188145	927	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YLL012W	YLL012W	YEH1	hom	Verified	0.71280459634369	0.237983340508026	no	1137	0.208696649062618	675	NA	FT	LIPID METABOLISM			Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes	sterol metabolic process	sterol esterase activity	integral to membrane|lipid particle
YNL056W	YNL056W	OCA2	hom	Verified	0.710498052200529	0.238697669189864	no	1138	0.237802143783523	783	NA					Putative protein with similarity to predicted tyrosine phosphatases Oca1p and Siw14p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YNL056W is not an essential gene	biological_process	molecular_function	cytoplasm
YER137C_p	YER137C	YER137C	hom	Uncharacterized	0.709678305624858	0.238951824129708	no	1139	0.245038382565917	868	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YOR043W	YOR043W	WHI2	hom	Verified	0.709406656184789	0.239036079188374	no	1140	0.211169812149963	711	NA	FT	VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION			Protein required, with binding partner Psr1p, for full activation of the general stress response, possibly through Msn2p dephosphorylation; regulates growth during the diauxic shift; negative regulator of G1 cyclin expression	response to salt stress|mitochondrion degradation|actin filament organization|endocytosis|response to heat|regulation of growth|response to stress	phosphatase activator activity	cellular_component
YBR261C	YBR261C	TAE1	hom	Verified	0.708361174790306	0.23936049821239	no	1141	0.208664114219103	699	NA	FT	TRANSLATION			AdoMet-dependent proline methyltransferase; catalyzes the dimethylation of ribosomal proteins Rpl12 and Rps25 at N-terminal proline residues; has a role in protein synthesis; fusion protein localizes to the cytoplasm	cytoplasmic translation|N-terminal peptidyl-proline dimethylation	N-terminal protein N-methyltransferase activity	cytosol|cytoplasm
YMR195W	YMR195W	ICY1	hom	Verified	0.707154233493014	0.239735318072425	no	1142	0.222611189674604	755	NA					Protein of unknown function, required for viability in rich media of cells lacking mitochondrial DNA; mutants have an invasive growth defect with elongated morphology; induced by amino acid starvation	biological_process	molecular_function	fungal-type vacuole membrane
YNL291C	YNL291C	MID1	hom	Verified	0.706383327933161	0.239974893013747	no	1143	0.214889877104118	695	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	ENDOPLASMIC RETICULUM|PLASMA MEMBRANE		N-glycosylated integral membrane protein of the ER membrane and plasma membrane, functions as a stretch-activated Ca2+-permeable cation channel required for Ca2+ influx stimulated by pheromone; interacts with Cch1p; forms an oligomer	calcium ion transport	stretch-activated, cation-selective, calcium channel activity|calcium channel activity	endoplasmic reticulum|plasma membrane
YNL226W_d	YNL226W	YNL226W	hom	Dubious	0.706101450074176	0.240062525007966	no	1144	0.239455596038699	806	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene JJJ1/YNL227C	Unknown	Unknown	Unknown
YEL030W	YEL030W	ECM10	hom	Verified	0.705613619922285	0.240214225985141	no	1145	0.221048817483175	744	NA	FT	PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Heat shock protein of the Hsp70 family; localized in mitochondrial nucleoids, plays a role in protein translocation, interacts with Mge1p in an ATP-dependent manner; overexpression induces extensive mitochondrial DNA aggregations; ECM10 has a paralog, SSC1, that arose from the whole genome duplication	protein refolding|protein targeting to mitochondrion	molecular_function	mitochondrial nucleoid|mitochondrion
YBR083W	YBR083W	TEC1	hom	Verified	0.705234590039705	0.240332129300551	no	1146	0.204602021354562	710	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Transcription factor targeting filamentation genes and Ty1 expression; Ste12p activation of most filamentation gene promoters depends on Tec1p and Tec1p transcriptional activity is dependent on its association with Ste12p; binds to TCS elements upstream of filamentation genes, which are regulated by Tec1p/Ste12p/Dig1p complex; competes with Dig2p for binding to Ste12p/Dig1p; positive regulator of chronological life span; TEA/ATTS DNA-binding domain family member	pseudohyphal growth|chronological cell aging|positive regulation of transposition, RNA-mediated|invasive growth in response to glucose limitation|positive regulation of transcription from RNA polymerase II promoter in response to stress	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II transcription factor recruiting transcription factor activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YOR001W	YOR001W	RRP6	hom	Verified	0.70520224775566	0.240342191345661	no	1147	0.172639413228945	612	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|RNA LOCALIZATION	NUCLEUS		Nuclear exosome exonuclease component; has 3'-5' exonuclease activity; involved in RNA processing, maturation, surveillance, degradation, tethering, and export; has similarity to E. coli RNase D and to human PM-Sc1 100 (EXOSC10); mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay	nuclear polyadenylation-dependent rRNA catabolic process|nuclear polyadenylation-dependent snRNA catabolic process|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|histone mRNA catabolic process|nuclear polyadenylation-dependent antisense transcript catabolic process|U1 snRNA 3'-end processing|polyadenylation-dependent snoRNA 3'-end processing|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|U5 snRNA 3'-end processing|nuclear polyadenylation-dependent tRNA catabolic process|nuclear polyadenylation-dependent CUT catabolic process|nuclear polyadenylation-dependent snoRNA catabolic process|nuclear retention of pre-mRNA at the site of transcription|nuclear polyadenylation-dependent mRNA catabolic process|U4 snRNA 3'-end processing|nuclear retention of pre-mRNA with aberrant 3'-ends at the site of transcription	3'-5'-exoribonuclease activity	nucleolus|nucleus|nuclear exosome (RNase complex)
YFR019W	YFR019W	FAB1	hom	Verified	0.705119818733146	0.24036783697126	no	1148	0.256440683698325	865	NA	FT	LIPID METABOLISM	MITOCHONDRION		1-phosphatidylinositol-3-phosphate 5-kinase; vacuolar membrane kinase that generates phosphatidylinositol (3,5)P2, which is involved in vacuolar sorting and homeostasis	phosphatidylinositol phosphorylation	1-phosphatidylinositol-3-phosphate 5-kinase activity|phosphatidylinositol-3-phosphate binding	endosome membrane|mitochondrion|fungal-type vacuole membrane|PAS complex
YOR038C	YOR038C	HIR2	hom	Verified	0.704864508023426	0.240447279651881	no	1149	0.232431428933789	771	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION	NUCLEUS		Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; recruits Swi-Snf complexes to histone gene promoters; promotes heterochromatic gene silencing with Asf1p	DNA replication-independent nucleosome assembly|regulation of transcription from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter	nucleosome binding|transcription corepressor activity|DNA binding	HIR complex|nucleus
YER095W	YER095W	RAD51	hom	Verified	0.704710890050678	0.24049508643042	no	1150	0.269125509180875	935	NA	FF|FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Strand exchange protein, forms a helical filament with DNA that searches for homology; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; homolog of Dmc1p and bacterial RecA protein	strand invasion|telomere maintenance via recombination|heteroduplex formation|meiotic joint molecule formation|reciprocal meiotic recombination|double-strand break repair via single-strand annealing	recombinase activity|single-stranded DNA binding|DNA-dependent ATPase activity	condensed nuclear chromosome|nuclear chromosome
YOR091W	YOR091W	TMA46	hom	Verified	0.70453804046447	0.240548884383526	no	1151	0.25473398254123	875	NA	FT	TRANSLATION			Protein of unknown function that associates with translating ribosomes; interacts with GTPase Rbg1p	cytoplasmic translation	molecular_function	polysomal ribosome|ribosome|cytoplasm
YPL105C	YPL105C	SYH1	hom	Verified	0.704203777172764	0.240652939555352	no	1152	0.235814198373596	839	NA	FT	PROTEIN LOCALIZATION	MITOCHONDRION		Protein of unknown function that influences nuclear pore distribution; co-purifies with ribosomes; contains a GYF domain, which bind proline-rich sequences; deletion extends chronological lifespan; SYH1 has a paralog, SMY2, that arose from the whole genome duplication	nuclear pore distribution	molecular_function	mitochondrion|ribosome|cytoplasmic mRNA processing body|extrinsic to membrane|cytoplasm
YLR364W	YLR364W	GRX8	hom	Verified	0.703806600389043	0.240776611356424	no	1153	0.206327726297323	676	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY			Glutaredoxin that employs a dithiol mechanism of catalysis; monomeric; activity is low and null mutation does not affect sensitivity to oxidative stress; GFP-fusion protein localizes to the cytoplasm; expression strongly induced by arsenic	biological_process	glutathione-disulfide reductase activity	cytoplasm
YBR212W	YBR212W	NGR1	hom	Verified	0.70347452538017	0.240880038487518	no	1154	0.25618440075392	891	NA	FT	MITOCHONDRION ORGANIZATION			RNA binding protein that negatively regulates growth rate; interacts with the 3' UTR of the mitochondrial porin (POR1) mRNA and enhances its degradation; overexpression impairs mitochondrial function; interacts with Dhh1p to mediate POR1 mRNA decay; expressed in stationary phase	3'-UTR-mediated mRNA destabilization|mitochondrion organization	mRNA binding	cytoplasmic mRNA processing body|cytoplasmic stress granule|perinuclear region of cytoplasm|cytoplasm
YLR139C	YLR139C	SLS1	hom	Verified	0.702720625509029	0.241114935674643	no	1155	0.2680101147	906	NA	FT	TRANSLATION|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Mitochondrial membrane protein that coordinates expression of mitochondrially-encoded genes; may facilitate delivery of mRNA to membrane-bound translation machinery	aerobic respiration|mitochondrial translation	molecular_function	mitochondrial nucleoid|mitochondrion|integral to membrane|mitochondrial inner membrane
YBR056W-A_p	YBR056W-A	YBR056W-A	hom	Uncharacterized	0.70199397219365	0.241341461297028	no	1156	0.274410638692901	912	NA					Protein of unknown function; mRNA identified as translated by ribosome profiling data; partially overlaps the dubious ORF YBR056C-B	biological_process	molecular_function	cellular_component
YBL055C	YBL055C	YBL055C	hom	Verified	0.701820097350052	0.241395681873394	no	1157	0.221261364963078	743	NA	FT	RESPONSE TO OXIDATIVE STRESS			3'-->5' exonuclease and endonuclease with a possible role in apoptosis; has similarity to mammalian and C. elegans apoptotic nucleases	cellular response to oxidative stress|apoptotic DNA fragmentation	3'-5'-exodeoxyribonuclease activity|endonuclease activity	cytoplasm
YER101C	YER101C	AST2	hom	Verified	0.700990602664434	0.241654439914958	no	1158	0.246599413248719	855	NA	FT	PROTEIN LOCALIZATION|OXIDATION-REDUCTION PROCESS			Lipid raft associated protein; overexpression restores Pma1p localization to lipid rafts which is required for targeting of Pma1p to the plasma membrane; sometimes classified in the medium-chain dehydrogenase/reductases (MDRs) superfamily; AST2 has a paralog, AST1, that arose from the whole genome duplication	protein targeting to membrane	molecular_function	cytoplasm
YER016W	YER016W	BIM1	hom	Verified	0.697970408877674	0.242597849998986	no	1159	0.238542590972905	834	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION	CHROMOSOME|CYTOSKELETON	KINETOCHORE	Microtubule-binding protein that together with Kar9p makes up the cortical microtubule capture site and delays the exit from mitosis when the spindle is oriented abnormally	nuclear migration along microtubule|microtubule nucleation|microtubule depolymerization|negative regulation of microtubule depolymerization|positive regulation of microtubule polymerization|mitotic sister chromatid cohesion|mitotic cell cycle spindle assembly checkpoint	microtubule plus-end binding|protein homodimerization activity|structural constituent of cytoskeleton	spindle midzone|microtubule plus end|cytoplasmic microtubule|spindle pole body|kinetochore|spindle pole|spindle
YFR013W	YFR013W	IOC3	hom	Verified	0.697876269294106	0.242627288152907	no	1160	0.286886432681466	980	NA	FT	CHROMATIN ORGANIZATION	NUCLEUS		Subunit of the Isw1a complex; Isw1a has nucleosome-stimulated ATPase activity and represses transcription initiation by specific positioning of a promoter proximal dinucleosome; IOC3 has a paralog, ESC8, that arose from the whole genome duplication	chromatin remodeling	nucleosome binding|ATPase activity|DNA binding	ISW1 complex
YEL003W	YEL003W	GIM4	hom	Verified	0.697819931061538	0.242644906465906	no	1161	0.238317223947983	819	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS			Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it	tubulin complex assembly	tubulin binding	prefoldin complex|cytoplasm
YER020W	YER020W	GPA2	hom	Verified	0.697582478439482	0.242719171192615	no	1162	0.224775710649537	764	NA	FT	SIGNALING|NUCLEOTIDE METABOLISM	MITOCHONDRION|PLASMA MEMBRANE		Nucleotide binding alpha subunit of the heterotrimeric G protein that interacts with the receptor Gpr1p, has signaling role in response to nutrients; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery	adenylate cyclase-activating G-protein coupled receptor signaling pathway|ascospore formation|replicative cell aging|signal transduction|glucose mediated signaling pathway|pseudohyphal growth|hexose mediated signaling|regulation of cell size	GTPase activity	mitochondrion|plasma membrane
YNL016W	YNL016W	PUB1	hom	Verified	0.69720153665794	0.242838338710519	no	1163	0.227537101937963	766	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS	NUCLEUS		Poly (A)+ RNA-binding protein; abundant mRNP-component protein that binds mRNA and is required for stability of many mRNAs; component of glucose deprivation induced stress granules, involved in P-body-dependent granule assembly; protein abundance increases in response to DNA replication stress	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|stress granule assembly|regulation of mRNA stability	mRNA binding|poly(U) RNA binding	nucleus|cytoplasmic stress granule|cytoplasm
YJR080C	YJR080C	AIM24	hom	Verified	0.696335822247193	0.243109272163246	no	1164	0.207377181544202	724	NA	FT		MITOCHONDRION		Protein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays reduced respiratory growth and elevated frequency of mitochondrial genome loss	biological_process	molecular_function	mitochondrion
YPL180W	YPL180W	TCO89	hom	Verified	0.696316474529964	0.243115329079819	no	1165	0.262649432400989	923	NA	FT	SIGNALING|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	PLASMA MEMBRANE		Subunit of TORC1 (Tor1p or Tor2p-Kog1p-Lst8p-Tco89p), a complex that regulates growth in response to nutrient availability; cooperates with Ssd1p in the maintenance of cellular integrity; deletion strains are hypersensitive to rapamycin	TOR signaling cascade|fungal-type cell wall organization|response to salt stress|regulation of cell growth|glycerol metabolic process	molecular_function	TORC1 complex|fungal-type vacuole membrane|extrinsic to internal side of plasma membrane|extrinsic to vacuolar membrane
YPR138C	YPR138C	MEP3	hom	Verified	0.694271573456033	0.24375595722995	no	1166	0.23385311962541	791	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Ammonium permease of high capacity and low affinity; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation ammonia permease	nitrogen utilization|ammonium transport	ammonium transmembrane transporter activity	integral to membrane|plasma membrane
YPL239W	YPL239W	YAR1	hom	Verified	0.693104726341784	0.24412191590924	no	1167	0.239206827061257	800	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RESPONSE TO OXIDATIVE STRESS			Ankyrin-repeat containing, nucleocytoplasmic shuttling chaperone; prevents aggregation of Rps3p in the cytoplasm, associates with free Rps3p in the cytoplasm and delivers it to the 90S in the nucleus; required for 40S ribosomal subunit export, biogenesis and adaptation to osmotic and oxidative stress; expression repressed by heat shock	ribosomal small subunit biogenesis|cellular response to oxidative stress|response to osmotic stress	molecular_function	cytoplasm
YHR017W	YHR017W	YSC83	hom	Verified	0.692890139421742	0.244189249122316	no	1168	0.270072468736325	971	NA	FT		MITOCHONDRION		Non-essential mitochondrial protein of unknown function; mRNA induced during meiosis, peaking between mid to late prophase of meiosis I; similar to S. douglasii YSD83	biological_process	molecular_function	mitochondrial outer membrane|mitochondrion
YLR326W_p	YLR326W	YLR326W	hom	Uncharacterized	0.692881469695268	0.244191969724752	no	1169	0.221722909044223	726	NA					Putative protein of unknown function, predicted to be palmitoylated	biological_process	molecular_function	cellular_component
YGL133W	YGL133W	ITC1	hom	Verified	0.692501299495126	0.24431128505638	no	1170	0.246578124466895	855	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS		Subunit of the ATP-dependent Isw2p-Itc1p chromatin remodeling complex, required for repression of a-specific genes, repression of early meiotic genes during mitotic growth, and repression of INO1; similar to mammalian Acf1p, the regulatory subunit of the mammalian ATP-utilizing chromatin assembly and modifying factor (ACF) complex	negative regulation of transcription from RNA polymerase II promoter by pheromones|chromatin remodeling|chromatin silencing at telomere	molecular_function	chromatin accessibility complex
YLR271W_p	YLR271W	YLR271W	hom	Uncharacterized	0.691470726918691	0.244634885303459	no	1171	0.223674714443032	749	NA	FT		NUCLEUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS	biological_process	molecular_function	nucleus|cytoplasm
YLR194C	YLR194C	YLR194C	hom	Verified	0.691196702190492	0.244720968020834	no	1172	0.240662902045336	800	NA	FT	CELL WALL ORG/BIOGENESIS	PLASMA MEMBRANE		Structural constituent of the cell wall attached to the plasma membrane by a GPI-anchor; expression is upregulated in response to cell wall stress	fungal-type cell wall organization	structural constituent of cell wall	fungal-type cell wall|anchored to plasma membrane
YNL004W	YNL004W	HRB1	hom	Verified	0.690862637157721	0.244825933984821	no	1173	0.254685175938843	873	NA	FT	RNA LOCALIZATION	NUCLEUS		Poly(A+) RNA-binding protein; involved in the export of mRNAs from the nucleus to the cytoplasm; similar to Npl3p; HRB1 has a paralog, GBP2, that arose from the whole genome duplication	poly(A)+ mRNA export from nucleus	RNA binding	integral to membrane|nucleus|cytoplasm
YGL141W	YGL141W	HUL5	hom	Verified	0.690040156847222	0.245084467265228	no	1174	0.256560682707586	865	NA	FT	PROTEOLYSIS	NUCLEUS		Multiubiquitin chain assembly factor (E4); proteasome processivity factor that elongates polyUb chains on substrates, opposing Ubp6p, a branched polyubiquitin protease; required for retrograde transport of misfolded proteins during ERAD	ER-associated protein catabolic process|protein polyubiquitination	ubiquitin-ubiquitin ligase activity	proteasome complex|nucleus|cytoplasm
YJR034W	YJR034W	PET191	hom	Verified	0.689797040758586	0.24516091495318	no	1175	0.255795890110183	872	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Protein required for assembly of cytochrome c oxidase; exists as an oligomer; described as both an integral mitochondrial inner membrane protein facing the intermembrane space (IMS) and as a soluble IMS protein; contains a twin Cx9C motif; imported into the IMS via the MIA import machinery	mitochondrial respiratory chain complex IV assembly	molecular_function	mitochondrion|integral to mitochondrial inner membrane
YJL127C	YJL127C	SPT10	hom	Verified	0.689409348650178	0.245282850996234	no	1176	0.246978309655802	848	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING	NUCLEUS		Putative histone acetylase with a role in transcriptional silencing, sequence-specific activator of histone genes, binds specifically and cooperatively to pairs of UAS elements in core histone promoters, functions at or near the TATA box	DNA repair|negative regulation of transcription from RNA polymerase II promoter|chromatin silencing at rDNA|chromatin remodeling|chromatin silencing at telomere|chromatin silencing at silent mating-type cassette	histone acetyltransferase activity|sequence-specific DNA binding	nucleus
YLR228C	YLR228C	ECM22	hom	Verified	0.688976554817044	0.245419010834773	no	1177	0.225275061637057	762	NA	FT	TRANSCRIPTION FROM RNA POL II|LIPID METABOLISM	NUCLEUS		Sterol regulatory element binding protein; regulates transcription of sterol biosynthetic genes; contains Zn[2]-Cys[6] binuclear cluster; relocates from intracellular membranes to perinuclear foci on sterol depletion; ECM22 has a paralog, UPC2, that arose from the whole genome duplication	positive regulation of ergosterol biosynthetic process by positive regulation of transcription from RNA polymerase II promoter|positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus|membrane|perinuclear region of cytoplasm
YOR172W	YOR172W	YRM1	hom	Verified	0.688852520060125	0.245458040486993	no	1178	0.245066942858049	834	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Zn2-Cys6 zinc-finger transcription factor that activates genes involved in multidrug resistance; paralog of Yrr1p, acting on an overlapping set of target genes	regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding|nucleic acid binding transcription factor activity	nucleus|cytoplasm
YLR001C_p	YLR001C	YLR001C	hom	Uncharacterized	0.688133969544273	0.245684210275059	no	1179	0.227323573399958	771	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; predicted to be palmitoylated	biological_process	molecular_function	mitochondrion|fungal-type vacuole membrane
YDL172C_d	YDL172C	YDL172C	hom	Dubious	0.687355302236641	0.245929428613213	no	1180	0.269713496636519	920	NA					Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YGL223C	YGL223C	COG1	hom	Verified	0.686257609083196	0.246275337708445	no	1181	0.303573392353296	1016	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments	retrograde transport, vesicle recycling within Golgi|intra-Golgi vesicle-mediated transport|CVT pathway	molecular_function	Golgi transport complex
YOR366W_d	YOR366W	YOR366W	hom	Dubious	0.685878143781673	0.246394976850018	no	1182	0.255710455066983	882	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR365C	Unknown	Unknown	Unknown
YLR315W	YLR315W	NKP2	hom	Verified	0.685479956888861	0.24652055208467	no	1183	0.291917904414975	984	NA	FT	CELL CYCLE|CELL DIVISION	NUCLEUS|CHROMOSOME|CYTOSKELETON	KINETOCHORE	Central kinetochore protein and subunit of the Ctf19 complex; mutants have elevated rates of chromosome loss; orthologous to fission yeast kinetochore protein cnl2	biological_process	molecular_function	spindle pole body|kinetochore
YHR155W	YHR155W	YSP1	hom	Verified	0.685457773985187	0.24652754886137	no	1184	0.263460859886144	921	NA	FF|FT		MITOCHONDRION		Mitochondrial protein; potential role in promoting mitochondrial fragmentation during programmed cell death in response to high levels of alpha-factor mating pheromone or the drug amiodarone; YSP1 has a paralog, SIP3, that arose from the whole genome duplication	biological_process	molecular_function	mitochondrion
YBR258C	YBR258C	SHG1	hom	Verified	0.685301992968252	0.246576687219645	no	1185	0.233895328027911	770	NA	FT	CHROMATIN ORGANIZATION	NUCLEUS		Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres	histone H3-K4 methylation	histone methyltransferase activity (H3-K4 specific)	nucleus|Set1C/COMPASS complex
YBR296C	YBR296C	PHO89	hom	Verified	0.683183056280779	0.247245588930865	no	1186	0.260786028009528	901	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Na+/Pi cotransporter, active in early growth phase; similar to phosphate transporters of Neurospora crassa; transcription regulated by inorganic phosphate concentrations and Pho4p; mutations in related human transporter genes hPit1 and hPit2 are associated with hyperphosphatemia-induced calcification of vascular tissue and familial idiopathic basal ganglia calcification	phosphate ion transport|transmembrane transport	sodium:inorganic phosphate symporter activity	integral to membrane|plasma membrane
YNL014W	YNL014W	HEF3	hom	Verified	0.682994690617299	0.247305098751626	no	1187	0.259051856562015	889	NA	FT	TRANSLATION|NUCLEOTIDE METABOLISM		RIBOSOME	Translational elongation factor EF-3; member of the ABC superfamily; stimulates EF-1 alpha-dependent binding of aminoacyl-tRNA by the ribosome; normally expressed in zinc deficient cells; HEF3 has a paralog, YEF3, that arose from the whole genome duplication	translational elongation	ATPase activity|translation elongation factor activity	cytosolic ribosome
YDL159W-A_p	YDL159W-A	YDL159W-A	hom	Uncharacterized	0.682590518243904	0.247432813601902	no	1188	0.23846355856289	828	NA					Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species	biological_process	molecular_function	cellular_component
YDR359C	YDR359C	EAF1	hom	Verified	0.681708760545933	0.247711563423738	no	1189	0.279841479651361	947	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE	NUCLEUS	HISTONE ACETYLTRANSFERASE	Component of the NuA4 histone acetyltransferase complex; acts as a platform for assembly of NuA4 subunits into the native complex; required for initiation of pre-meiotic DNA replication, likely due to its requirement for expression of IME1	DNA repair|cellular protein complex assembly|chromatin modification	molecular_function	histone acetyltransferase complex|NuA4 histone acetyltransferase complex
YHL010C	YHL010C	ETP1	hom	Verified	0.68158361689396	0.247751138637073	no	1190	0.196525649424447	670	NA					Putative protein of unknown function that is required for growth on ethanol; contains a zinc finger region and has homology to human BRAP2, which is a cytoplasmic protein that binds nuclear localization sequences	response to ethanol	ubiquitin binding|nuclear localization sequence binding	cellular_component
YDR424C	YDR424C	DYN2	hom	Verified	0.681512278851279	0.247773699967712	no	1191	0.254337508147869	868	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS	ENDOMEMBRANE SYSTEM|NUCLEUS|CYTOSKELETON		Cytoplasmic light chain dynein, microtubule motor protein; proposed to be involved in the assembly of the nuclear pore complex	microtubule-based process|actin filament-based process|nuclear pore complex assembly	molecular_function	cytoplasmic dynein complex|cytoplasmic microtubule|peroxisome|nuclear pore
YKL077W_p	YKL077W	YKL077W	hom	Uncharacterized	0.681357484784398	0.247822658827533	no	1192	0.259392538307289	876	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole	biological_process	molecular_function	fungal-type vacuole
YOL008W	YOL008W	COQ10	hom	Verified	0.680844198389195	0.247985039960935	no	1193	0.2396532902389	828	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Coenzyme Q (ubiquinone) binding protein, functions in the delivery of Q<sub>6</sub> to its proper location for electron transport during respiration; START domain protein with homologs in bacteria and eukaryotes	cellular respiration	ubiquinone binding	mitochondrion|mitochondrial inner membrane
YOR097C_p	YOR097C	YOR097C	hom	Uncharacterized	0.680697384311085	0.248031495887283	no	1194	0.267392438616334	957	NA					Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen; YOR097C is not an essential gene	biological_process	molecular_function	cellular_component
YHR018C	YHR018C	ARG4	hom	Verified	0.676679460562353	0.249304675502204	no	1195	0.241444685329731	816	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Argininosuccinate lyase, catalyzes the final step in the arginine biosynthesis pathway	arginine biosynthetic process via ornithine	argininosuccinate lyase activity	cytosol
YHR135C	YHR135C	YCK1	hom	Verified	0.675625805712035	0.249639126528115	no	1196	0.244672289111053	845	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CELL DIVISION|PROTEIN PHOSPHORYLATION	ENDOPLASMIC RETICULUM|MITOCHONDRION|PLASMA MEMBRANE		Palmitoylated plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck2p in morphogenesis, proper septin assembly, endocytic trafficking; YCK1 has a paralog, YCK2, that arose from the whole genome duplication	cell morphogenesis|endocytosis|protein phosphorylation|cytokinesis|response to glucose stimulus	protein serine/threonine kinase activity|protein kinase activity	mitochondrion|endoplasmic reticulum|plasma membrane
YBL062W_d	YBL062W	YBL062W	hom	Dubious	0.675234452156909	0.249763410608759	no	1197	0.278725641915368	969	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YPR064W_d	YPR064W	YPR064W	hom	Dubious	0.674914016540458	0.249865197387923	no	1198	0.245603342829536	854	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YML100W-A_p	YML100W-A	YML100W-A	hom	Uncharacterized	0.672958456408227	0.250486860483145	no	1199	0.21519153617685	718	NA					Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching	biological_process	molecular_function	cellular_component
YOR371C	YOR371C	GPB1	hom	Verified	0.672392457585676	0.25066694158624	no	1200	0.242881724823256	839	NA	FT	SIGNALING|PROTEOLYSIS	PLASMA MEMBRANE		Multistep regulator of cAMP-PKA signaling; inhibits PKA downstream of Gpa2p and Cyr1p, thereby increasing cAMP dependency; promotes ubiquitin-dependent proteolysis of Ira2p; regulated by G-alpha protein Gpa2p; GPB1 has a paralog, GPB2, that arose from the whole genome duplication	positive regulation of Ras protein signal transduction|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|negative regulation of phosphorylation|signal transduction|glucose mediated signaling pathway|pseudohyphal growth|invasive growth in response to glucose limitation|negative regulation of Ras protein signal transduction|protein polyubiquitination	cAMP-dependent protein kinase inhibitor activity|signal transducer activity|GTPase activating protein binding	plasma membrane|cytoplasm
YDR385W	YDR385W	EFT2	hom	Verified	0.672190933116589	0.250731076199891	no	1201	0.241430936154871	820	NA	FT	TRANSLATION|NUCLEOTIDE METABOLISM		RIBOSOME	Elongation factor 2 (EF-2), also encoded by EFT1; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin; EFT2 has a paralog, EFT1, that arose from the whole genome duplication	translational elongation|positive regulation of translational elongation	translation elongation factor activity	ribosome
YGL199C_d	YGL199C	YGL199C	hom	Dubious	0.670575578940294	0.251245472090746	no	1202	0.221876309683711	737	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YIP4/YGL198W	Unknown	Unknown	Unknown
YJL126W	YJL126W	NIT2	hom	Verified	0.670188005995862	0.251368974376532	no	1203	0.254001247006874	897	NA					Nit protein, one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member	biological_process	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	cellular_component
YNL324W_d	YNL324W	YNL324W	hom	Dubious	0.669188390841021	0.25168765539552	no	1204	0.276674859869808	923	NA					Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YBR225W_p	YBR225W	YBR225W	hom	Uncharacterized	0.669106427804525	0.251713794977334	no	1205	0.231570575900387	814	NA					Putative protein of unknown function; non-essential gene identified in a screen for mutants affected in mannosylphophorylation of cell wall components	biological_process	molecular_function	cellular_component
YKL069W	YKL069W	YKL069W	hom	Verified	0.668442200427298	0.251925682682446	no	1206	0.249486334115933	856	NA	FT	OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		Methionine-R-sulfoxide reductase; reduces the R enantiomer of free Met-SO, in contrast to Ycl033Cp which reduces Met-R-SO in a peptide linkage; has a role in protection against oxidative stress; relative distribution to the nucleus increases upon DNA replication stress	cellular response to oxidative stress	methionine-R-sulfoxide reductase activity	nucleus|cytoplasm
YBR262C	YBR262C	AIM5	hom	Verified	0.667071635783603	0.25236318843534	no	1207	0.202033772993784	657	NA	FT	MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial inner membrane protein; subunit of the mitochondrial inner membrane organizing system (MitOS, MICOS, or MINOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture	cristae formation	molecular_function	mitochondrion|mitochondrial crista junction|integral to mitochondrial inner membrane
YLR037C	YLR037C	PAU23	hom	Verified	0.6651113841393	0.25298962690823	no	1208	0.252790953664526	850	NA	FT	CELL WALL ORG/BIOGENESIS			Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; member of the seripauperin multigene family encoded mainly in subtelomeric regions; expressed under anaerobic conditions, completely repressed during aerobic growth	biological_process	molecular_function	fungal-type cell wall
YML108W	YML108W	YML108W	hom	Verified	0.665019014551037	0.253019165671207	no	1209	0.229018204465862	749	NA	FT		NUCLEUS		Protein of unknown function; structure defines a new subfamily of the split beta-alpha-beta sandwiches; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YML108W is not an essential gene; relative distribution to the nucleus increases upon DNA replication stress	biological_process	molecular_function	nucleus|cytoplasm
YPR108W-A_p	YPR108W-A	YPR108W-A	hom	Uncharacterized	0.664511502104435	0.253181494855027	no	1210	0.263194598927195	875	NA					Putative protein of unknown function; identified by fungal homology and RT-PCR	biological_process	molecular_function	cellular_component
YPL062W_d	YPL062W	YPL062W	hom	Dubious	0.663960103514675	0.253357923197075	no	1211	0.279092896932232	972	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPL062W is not an essential gene; homozygous diploid mutant shows a decrease in glycogen accumulation	Unknown	Unknown	Unknown
YAL021C	YAL021C	CCR4	hom	Verified	0.663600934585236	0.253472879491587	no	1212	0.303639766331596	1047	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|RNA PROCESSING	NUCLEUS	RNA POL II, HOLOENZYME	Component of the CCR4-NOT transcriptional complex, which is involved in regulation of gene expression; component of the major cytoplasmic deadenylase, which is involved in mRNA poly(A) tail shortening	regulation of transcription from RNA polymerase II promoter|positive regulation of transcription elongation from RNA polymerase II promoter|nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|DNA replication checkpoint|nuclear-transcribed mRNA poly(A) tail shortening|traversing start control point of mitotic cell cycle|replication fork protection|transcription elongation from RNA polymerase II promoter|DNA replication	3'-5'-exoribonuclease activity	CCR4-NOT core complex|cytoplasmic mRNA processing body|Cdc73/Paf1 complex|cytoplasm
YDL135C	YDL135C	RDI1	hom	Verified	0.663578893027144	0.253479935047333	no	1213	0.222459080648945	724	NA	FT	MEMBRANE ORGANIZATION|SIGNALING|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH		Rho GDP dissociation inhibitor; involved in the localization and regulation of Cdc42p and Rho1p; protein abundance increases in response to DNA replication stress	regulation of vacuole fusion, non-autophagic|actin filament organization|small GTPase mediated signal transduction	Rho GDP-dissociation inhibitor activity	cytosol|plasma membrane|cellular bud neck|cellular bud tip
YDL189W	YDL189W	RBS1	hom	Verified	0.663509552670302	0.253502131735262	no	1214	0.240186918187185	798	NA	FT	CARBOHYDRATE METABOLISM			Protein of unknown function, identified as a high copy suppressor of psk1 psk2 mutations that confer temperature-sensitivity for galactose utilization; proposed to bind single-stranded nucleic acids via its R3H domain	galactose metabolic process	molecular_function	cytoplasm
YNL107W	YNL107W	YAF9	hom	Verified	0.660980379986706	0.254312448018963	no	1215	0.283249011689202	965	NA	FF|FT	CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING	NUCLEUS|CHROMOSOME	HISTONE ACETYLTRANSFERASE	Subunit of both the NuA4 histone H4 acetyltransferase complex and the SWR1 complex, may function to antagonize silencing near telomeres; interacts directly with Swc4p, has homology to human leukemogenic protein AF9, contains a YEATS domain	DNA repair|chromatin remodeling|histone exchange|chromatin silencing at telomere	molecular_function	Swr1 complex|nucleus|NuA4 histone acetyltransferase complex|cytoplasm
YFL056C	YFL056C	AAD6	hom	Verified	0.660580634866634	0.254440645663085	no	1216	0.248366342989884	857	NA	FT	OXIDATION-REDUCTION PROCESS			Putative aryl-alcohol dehydrogenase; involved in oxidative stress response; similar to P. chrysosporium aryl-alcohol dehydrogenase; expression induced in cells treated with the mycotoxin patulin	cellular aldehyde metabolic process	aryl-alcohol dehydrogenase (NAD+) activity	cellular_component
YBL039W-B_p	YBL039W-B	YBL039W-B	hom	Uncharacterized	0.660162173642401	0.2545748818045	no	1217	0.237230371242668	810	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YDR263C	YDR263C	DIN7	hom	Verified	0.659911327465179	0.254655367310683	no	1218	0.264534995669683	906	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS|MITOCHONDRION		Mitochondrial nuclease functioning in DNA repair and replication, modulates the stability of the mitochondrial genome, induced by exposure to mutagens, also induced during meiosis at a time nearly coincident with commitment to recombination	DNA repair	nuclease activity	mitochondrion
YOL141W	YOL141W	PPM2	hom	Verified	0.65872177638405	0.255037223300617	no	1219	0.212997434119293	699	NA	FT	RNA PROCESSING	MITOCHONDRION		AdoMet-dependent tRNA methyltransferase also involved in methoxycarbonylation; required for the synthesis of wybutosine (yW), a modified guanosine found at the 3'-position adjacent to the anticodon of phe-tRNA; similarity to Ppm1p	tRNA methylation|wybutosine biosynthetic process	tRNA methyltransferase activity	mitochondrion|cytoplasm
YBL031W	YBL031W	SHE1	hom	Verified	0.658506385366244	0.255106397660755	no	1220	0.257157410698003	877	NA	FT	CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION	NUCLEUS|SITE OF POLARIZED GROWTH|CYTOSKELETON		Mitotic spindle protein; interacts with components of the Dam1 (DASH) complex, its effector Sli15p, and microtubule-associated protein Bim1p; also localizes to nuclear microtubules and to the bud neck in a ring-shaped structure; inhibits dynein function	mitotic spindle elongation	molecular_function	microtubule cytoskeleton|nuclear microtubule|cellular bud neck|astral microtubule|spindle
YJR102C	YJR102C	VPS25	hom	Verified	0.65832919693048	0.255163310345531	no	1221	0.306460370334063	1060	NA	FF|FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|PROTEOLYSIS|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS			Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome	negative regulation of transcription from RNA polymerase II promoter by glucose|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|protein targeting to vacuole	structural molecule activity	ESCRT II complex
YBR039W	YBR039W	ATP3	hom	Verified	0.658325694179622	0.25516443549127	no	1222	0.279265438078945	988	NA	FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS	MITOCHONDRION		Gamma subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis	ATP synthesis coupled proton transport	proton-transporting ATPase activity, rotational mechanism	mitochondrion|integral to membrane|mitochondrial proton-transporting ATP synthase, central stalk
YBR103W	YBR103W	SIF2	hom	Verified	0.657994783285985	0.255270741642451	no	1223	0.264733036511626	925	NA	FT	CELL CYCLE|CHROMATIN ORGANIZATION|SIGNALING|GENE SILENCING	NUCLEUS|CHROMOSOME		WD40 repeat-containing subunit of the Set3C histone deacetylase complex, which represses early/middle sporulation genes; antagonizes telomeric silencing; binds specifically to the Sir4p N-terminus	negative regulation of meiosis|negative regulation of chromatin silencing at telomere|regulation of transcription, DNA-dependent|histone deacetylation|positive regulation of stress-activated MAPK cascade	molecular_function	Rpd3L-Expanded complex|nucleus|Set3 complex
YBR286W	YBR286W	APE3	hom	Verified	0.656935924613879	0.255611058792484	no	1224	0.262850613753365	919	NA	FT	PROTEOLYSIS			Vacuolar aminopeptidase Y, processed to mature form by Prb1p	vacuolar protein catabolic process	aminopeptidase activity	fungal-type vacuole
YOL077W-A	YOL077W-A	ATP19	hom	Verified	0.65687744402848	0.255629861353718	no	1225	0.236306291948589	813	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS	MITOCHONDRION		Subunit k of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; associated only with the dimeric form of ATP synthase	mitochondrial proton-transporting ATP synthase complex assembly|ATP synthesis coupled proton transport	hydrogen ion transporting ATP synthase activity, rotational mechanism	mitochondrion|mitochondrial proton-transporting ATP synthase complex|mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
YLR292C	YLR292C	SEC72	hom	Verified	0.656307273443781	0.25581321930931	no	1226	0.27472337844328	929	NA	FT	PROTEIN LOCALIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER	posttranslational protein targeting to membrane, translocation	protein transporter activity	Sec62/Sec63 complex|endoplasmic reticulum membrane
YER066C-A_d	YER066C-A	YER066C-A	hom	Dubious	0.656105975422238	0.255877970002299	no	1227	0.236775178878825	808	NA					Dubious open reading frame unlikely to encode a protein, partially overlaps uncharacterized ORF YER067W	Unknown	Unknown	Unknown
YLL046C	YLL046C	RNP1	hom	Verified	0.655961092977257	0.255924579025655	no	1228	0.232154795649582	792	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS			Ribonucleoprotein that contains two RNA recognition motifs (RRM)	ribosome biogenesis	RNA binding	cytoplasm
YPL116W	YPL116W	HOS3	hom	Verified	0.653691793483913	0.25665519573036	no	1229	0.234926569180729	802	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION	NUCLEUS|SITE OF POLARIZED GROWTH		Trichostatin A-insensitive homodimeric histone deacetylase (HDAC) with specificity in vitro for histones H3, H4, H2A, and H2B; similar to Hda1p, Rpd3p, Hos1p, and Hos2p; deletion results in increased histone acetylation at rDNA repeats	regulation of transcription involved in G1/S phase of mitotic cell cycle|positive regulation of transcription from RNA polymerase II promoter|histone deacetylation	histone deacetylase activity	nucleus|cellular bud neck|cytoplasm
YER001W	YER001W	MNN1	hom	Verified	0.653474894480455	0.256725084690248	no	1230	0.234130202637893	804	NA	FT	CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Alpha-1,3-mannosyltransferase, integral membrane glycoprotein of the Golgi complex, required for addition of alpha1,3-mannose linkages to N-linked and O-linked oligosaccharides, one of five S. cerevisiae proteins of the MNN1 family	N-glycan processing|protein O-linked glycosylation	alpha-1,3-mannosyltransferase activity	Golgi apparatus
YGL050W	YGL050W	TYW3	hom	Verified	0.653120077363265	0.256839434831431	no	1231	0.255526889266004	856	NA	FT	RNA PROCESSING			tRNA methyltransferase required for synthesis of wybutosine, a modified guanosine found at the 3'-position adjacent to the anticodon of phenylalanine tRNA which supports reading frame maintenance by stabilizing codon-anticodon interactions	tRNA methylation|wybutosine biosynthetic process	tRNA methyltransferase activity	cellular_component
YHL042W_p	YHL042W	YHL042W	hom	Uncharacterized	0.651931691253352	0.257222619820833	no	1232	0.234143596873268	774	NA					Putative protein of unknown function; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins	biological_process	molecular_function	cellular_component
YPR155C	YPR155C	NCA2	hom	Verified	0.651522706556807	0.25735456216367	no	1233	0.238647931375754	834	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Protein involved in regulation of mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p) of the Fo-F1 ATP synthase; functions with Nca3p	mRNA metabolic process|aerobic respiration	molecular_function	mitochondrial outer membrane|mitochondrion
YOR286W	YOR286W	RDL2	hom	Verified	0.651518821984232	0.257355815532227	no	1234	0.247551185301128	818	NA	FT		MITOCHONDRION		Protein with rhodanese activity; contains a rhodanese-like domain similar to Rdl1p, Uba4p, Tum1p, and Ych1p; overexpression causes a cell cycle delay; null mutant displays elevated frequency of mitochondrial genome loss	biological_process	thiosulfate sulfurtransferase activity	mitochondrion
YOR290C	YOR290C	SNF2	hom	Verified	0.651415799985283	0.25738905703522	no	1235	0.332466162271128	1135	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS	NUCLEUS	RSC COMPLEX	Catalytic subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; contains DNA-stimulated ATPase activity; functions interdependently in transcriptional activation with Snf5p and Snf6p	cellular alcohol catabolic process|ATP-dependent chromatin remodeling|double-strand break repair|strand invasion|positive regulation of mating type switching|sucrose catabolic process|positive regulation of transcription from RNA polymerase II promoter in response to amino acid starvation|nucleosome mobilization|chromatin remodeling|DNA-dependent DNA replication|positive regulation of transcription from RNA polymerase II promoter	histone acetyl-lysine binding|RNA polymerase II activating transcription factor binding|DNA-dependent ATPase activity|nucleosomal DNA binding	SWI/SNF complex|nucleus
YPL074W	YPL074W	YTA6	hom	Verified	0.650602847389569	0.257651445916016	no	1236	0.208669108025556	738	NA					Putative ATPase of the CDC48/PAS1/SEC18 (AAA) family; localized to the cortex of mother cells but not to daughter cells; relocalizes from cytoplasm to plasma membrane foci upon DNA replication stress	biological_process	ATPase activity	cell cortex
YPL033C	YPL033C	SRL4	hom	Verified	0.650489407075526	0.257688070992872	no	1237	0.249541375220066	847	NA	FT	NUCLEOTIDE METABOLISM			Protein of unknown function; involved in regulation of dNTP production; null mutant suppresses the lethality of lcd1 and rad53 mutations; expression is induced by Kar4p	deoxyribonucleoside triphosphate metabolic process	molecular_function	cellular_component
YIL135C	YIL135C	VHS2	hom	Verified	0.650159384715966	0.257794636614683	no	1238	0.221236969492186	776	NA	FT	CELL CYCLE			Cytoplasmic protein of unknown function; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; similar to Mlf3p	G1/S transition of mitotic cell cycle	molecular_function	cytoplasm
YPL112C	YPL112C	PEX25	hom	Verified	0.649855045601833	0.257892929275313	no	1239	0.259584069941444	925	NA	FT	PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION			Peripheral peroxisomal membrane peroxin required for the regulation of peroxisome size and maintenance, recruits GTPase Rho1p to peroxisomes, induced by oleate, interacts with homologous protein Pex27p	protein import into peroxisome matrix|peroxisome organization	molecular_function	peroxisomal membrane
YMR085W_p	YMR085W	YMR085W	hom	Uncharacterized	0.649634442690913	0.25796418973789	no	1240	0.269579999355073	961	NA	FT	CARBOHYDRATE METABOLISM			Putative protein of unknown function; YMR085W and adjacent ORF YMR084W are merged in related strains, and together are paralogous to glutamine-fructose-6-phosphate amidotransferase GFA1	biological_process	molecular_function	cellular_component
YML088W	YML088W	UFO1	hom	Verified	0.649496691550748	0.258008692109324	no	1241	0.24799536488114	834	NA	FT	RESPONSE TO DNA DAMAGE|PROTEOLYSIS	NUCLEUS	UBIQUITIN LIGASE COMPLEX	F-box receptor protein, subunit of the Skp1-Cdc53-F-box receptor (SCF) E3 ubiquitin ligase complex; binds to phosphorylated Ho endonuclease, allowing its ubiquitylation by SCF and subsequent degradation	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|cellular response to methylmercury|response to DNA damage stimulus	ubiquitin-protein ligase activity|protein binding, bridging	SCF ubiquitin ligase complex|nucleus|cytoplasm
YBR216C	YBR216C	YBP1	hom	Verified	0.648976838216809	0.258176673632711	no	1242	0.248517210682942	811	NA	FT	RESPONSE TO OXIDATIVE STRESS			Protein involved in cellular response to oxidative stress; required for oxidation of specific cysteine residues of transcription factor Yap1p, resulting in nuclear localization of Yap1p in response to stress; YBP1 has a paralog, YBP2, that arose from the whole genome duplication	cellular response to oxidative stress	molecular_function	cytoplasm
YJL155C	YJL155C	FBP26	hom	Verified	0.648753762297407	0.258248774100759	no	1243	0.252764413587994	889	NA	FT	CARBOHYDRATE METABOLISM			Fructose-2,6-bisphosphatase, required for glucose metabolism; protein abundance increases in response to DNA replication stress	glucose metabolic process	6-phosphofructo-2-kinase activity|fructose-2,6-bisphosphate 2-phosphatase activity	cytosol
YIL111W	YIL111W	COX5B	hom	Verified	0.648514458872741	0.25832613106951	no	1244	0.243468615227518	829	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Subunit Vb of cytochrome c oxidase; cytochrome c oxidase is the terminal member of the mitochondrial inner membrane electron transport chain; Cox5Bp is predominantly expressed during anaerobic growth while its isoform Va (Cox5Ap) is expressed during aerobic growth; COX5B has a paralog, COX5A, that arose from the whole genome duplication	mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity|nitrite reductase (NO-forming) activity	mitochondrion|integral to membrane|mitochondrial respiratory chain complex IV
YOR376W-A_p	YOR376W-A	YOR376W-A	hom	Uncharacterized	0.648210887271109	0.258424280575651	no	1245	0.242716473064789	812	NA					Putative protein of unknown function; identified by fungal homology and RT-PCR	biological_process	molecular_function	cellular_component
YML059C	YML059C	NTE1	hom	Verified	0.647618408478329	0.258615893983694	no	1246	0.258384991356889	875	NA	FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Serine esterase, homolog of human neuropathy target esterase (NTE); Nte1p-mediated phosphatidylcholine turnover influences transcription factor Opi1p localization, affecting transcriptional regulation of phospholipid biosynthesis genes	phosphatidylcholine catabolic process|regulation of phospholipid biosynthetic process	lysophospholipase activity|carboxylesterase activity	integral to membrane|endoplasmic reticulum
YER049W	YER049W	TPA1	hom	Verified	0.6468388195934	0.258868132648733	no	1247	0.240472330826874	783	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|OXIDATION-REDUCTION PROCESS	NUCLEUS		Poly(rA)-binding protein involved in translation termination efficiency, mRNA poly(A) tail length and mRNA stability; interacts with Sup45p (eRF1), Sup35p (eRF3) and Pab1p; similar to prolyl 4-hydroxylases; binds Fe(III) and 2-oxoglutarate	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|translational termination	poly(A) RNA binding	nucleus
YIL045W	YIL045W	PIG2	hom	Verified	0.646332926119742	0.259031884296286	no	1248	0.241910615339883	827	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY			Putative type-1 protein phosphatase targeting subunit that tethers Glc7p type-1 protein phosphatase to Gsy2p glycogen synthase	regulation of glycogen biosynthetic process	protein phosphatase type 1 regulator activity	cytoplasm
YGL135W	YGL135W	RPL1B	hom	Verified	0.645938653675271	0.259159542688733	no	1249	0.286521463517288	979	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L1B; N-terminally acetylated; homologous to mammalian ribosomal protein L10A and bacterial L1; RPL1B has a paralog, RPL1A, that arose from the whole genome duplication; rpl1a rpl1b double null mutation is lethal	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YFL033C	YFL033C	RIM15	hom	Verified	0.645780957451984	0.259210611020113	no	1250	0.251186781931254	849	NA	FT	CELL CYCLE|SIGNALING|PROTEIN PHOSPHORYLATION|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		Glucose-repressible protein kinase involved in signal transduction during cell proliferation in response to nutrients, specifically the establishment of stationary phase; identified as a regulator of IME2; substrate of Pho80p-Pho85p kinase	protein phosphorylation|age-dependent response to oxidative stress involved in chronological cell aging|response to stress|regulation of meiosis	protein serine/threonine kinase activity|protein kinase activity	nucleus|cytoplasm
YNR055C	YNR055C	HOL1	hom	Verified	0.645764429944611	0.259215963587799	no	1251	0.247053193572492	857	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION|PLASMA MEMBRANE		Putative transporter in the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; mutations in membrane-spanning domains permit cation and histidinol uptake	organic alcohol transport|cation transport	alcohol transmembrane transporter activity|inorganic cation transmembrane transporter activity	mitochondrion|integral to membrane|plasma membrane
YDR102C_d	YDR102C	YDR102C	hom	Dubious	0.645095100048006	0.259432779513026	no	1252	0.243269592412594	797	NA					Dubious open reading frame; homozygous diploid deletion strain exhibits high budding index	Unknown	Unknown	Unknown
YHR110W	YHR110W	ERP5	hom	Verified	0.644328832520424	0.25968111138729	no	1253	0.238354821135917	818	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport	vesicle-mediated transport	molecular_function	integral to membrane
YGL217C_d	YGL217C	YGL217C	hom	Dubious	0.644242016362437	0.259709254491785	no	1254	0.239918519409817	806	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF KIP3/YGL216W	Unknown	Unknown	Unknown
YJR011C_p	YJR011C	YJR011C	hom	Uncharacterized	0.644236741507577	0.259710964486777	no	1255	0.247878335529857	824	NA					Putative protein of unknown function; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS	biological_process	molecular_function	cellular_component
YLR363C	YLR363C	NMD4	hom	Verified	0.643601157240263	0.259917049822094	no	1256	0.258931700975079	907	NA					Protein that may be involved in nonsense-mediated mRNA decay; interacts with Nam7p, relocalizes from nucleus to cytoplasmic foci upon DNA replication stress	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	molecular_function	cytoplasm
YML113W	YML113W	DAT1	hom	Verified	0.643519098948516	0.259943663000372	no	1257	0.24533017052529	849	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		DNA binding protein that recognizes oligo(dA).oligo(dT) tracts; Arg side chain in its N-terminal pentad Gly-Arg-Lys-Pro-Gly repeat is required for DNA-binding; not essential for viability	negative regulation of transcription from RNA polymerase II promoter	AT DNA binding	nucleus
YCL047C	YCL047C	POF1	hom	Verified	0.642954145077208	0.260126927207634	no	1258	0.272565977980148	938	NA	FT	PROTEOLYSIS			ATPase involved in the protein quality control and filamentation pathways; interacts physically with Kss1p and suppresses the filamentation defect of a kss1 deletion; also interacts with Ubc7p	pseudohyphal growth|ER-associated protein catabolic process|invasive growth in response to glucose limitation	ATPase activity	cellular_component
YER111C	YER111C	SWI4	hom	Verified	0.642916957257971	0.260138992822651	no	1259	0.255556051890191	899	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE	NUCLEUS|CHROMOSOME		DNA binding component of the SBF complex (Swi4p-Swi6p); a transcriptional activator that in concert with MBF (Mbp1-Swi6p) regulates late G1-specific transcription of targets including cyclins and genes required for DNA synthesis and repair; acetylation at two sites, K1016 and K1066, regulates interaction with Swi6p	positive regulation of transcription from RNA polymerase II promoter in response to heat stress|positive regulation of transcription involved in G1/S phase of mitotic cell cycle	sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	SBF transcription complex|nuclear chromatin
YMR300C	YMR300C	ADE4	hom	Verified	0.642036133873401	0.260424860925704	no	1260	0.270208460450632	936	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEOTIDE METABOLISM			Phosphoribosylpyrophosphate amidotransferase (PRPPAT; amidophosphoribosyltransferase), catalyzes first step of the 'de novo' purine nucleotide biosynthetic pathway	'de novo' IMP biosynthetic process	amidophosphoribosyltransferase activity	cytoplasm
YHR132W-A	YHR132W-A	IGO2	hom	Verified	0.641518496063408	0.260592933888657	no	1261	0.266638217369391	899	NA	FT		NUCLEUS		Protein required for initiation of G0 program; prevents degradation of nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway; phosphorylated by Rim15p; GFP protein localizes to the cytoplasm and nucleus; similar to Igo1p	mRNA stabilization	molecular_function	nucleus|cytoplasm
YML007W	YML007W	YAP1	hom	Verified	0.641512426188702	0.260594905060849	no	1262	0.28304585623685	975	NA	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		Basic leucine zipper (bZIP) transcription factor; required for oxidative stress tolerance; activated by H2O2 through the multistep formation of disulfide bonds and transit from the cytoplasm to the nucleus; Yap1p is degraded in the nucleus after the oxidative stress has passed; mediates resistance to cadmium; YAP1 has a paralog, CAD1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress	positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance|response to heat|response to drug|response to singlet oxygen|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|response to metal ion	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	nucleus|cytoplasm
YBR184W_p	YBR184W	YBR184W	hom	Uncharacterized	0.641435278768518	0.260619959104914	no	1263	0.25553456536575	909	NA					Putative protein of unknown function; YBR184W is not an essential gene	biological_process	molecular_function	cellular_component
YHR086W	YHR086W	NAM8	hom	Verified	0.64128382556485	0.260669147962165	no	1264	0.263643889421286	853	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING	NUCLEUS|MITOCHONDRION		RNA binding protein, component of the U1 snRNP protein; mutants are defective in meiotic recombination and in formation of viable spores, involved in the formation of DSBs through meiosis-specific splicing of REC107 pre-mRNA; Nam8p regulon embraces the meiotic pre-mRNAs of REC107, HFM1, AMA1 SPO22 and PCH2; the putative RNA binding domains RRM2 and RRM3 are required for Nam8p meiotic function	mRNA splicing, via spliceosome|positive regulation of mRNA splicing, via spliceosome|mRNA splice site selection	mRNA binding|RNA binding	commitment complex|U1 snRNP|U2-type prespliceosome
YDR351W	YDR351W	SBE2	hom	Verified	0.6410556764829	0.260743255068093	no	1265	0.262886256063293	919	NA	FT	PROTEIN LOCALIZATION|CELL WALL ORG/BIOGENESIS	GOLGI APPARATUS		Protein involved in the transport of cell wall components from the Golgi to the cell surface; required for bud growth	fungal-type cell wall organization	molecular_function	Golgi apparatus
YPL014W_p	YPL014W	YPL014W	hom	Uncharacterized	0.64100155069015	0.260760837732819	no	1266	0.2640362545811	917	NA	FT		NUCLEUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus	biological_process	molecular_function	nucleus|cytoplasm
YPR193C	YPR193C	HPA2	hom	Verified	0.640640750264311	0.260878058676157	no	1267	0.245303582114661	861	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CHROMATIN ORGANIZATION			Tetrameric histone acetyltransferase with similarity to Gcn5p, Hat1p, Elp3p, and Hpa3p; acetylates histones H3 and H4 in vitro and exhibits autoacetylation activity	protein homotetramerization|histone acetylation	histone acetyltransferase activity|protein homodimerization activity	cytoplasm
YLR181C	YLR181C	VTA1	hom	Verified	0.640185265601993	0.261026080407336	no	1268	0.253834803905226	865	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|VACUOLAR TRANSPORT			Multivesicular body (MVB) protein involved in endosomal protein sorting; regulates Vps4p activity by promoting its oligomerization; has an N-terminal Vps60- and Did2- binding domain, a linker region, and a C-terminal Vps4p binding domain	late endosome to vacuole transport via multivesicular body sorting pathway|positive regulation of protein oligomerization|late endosome to vacuole transport	ATPase activator activity	endosome|endosome membrane|multivesicular body
YCR020W-B	YCR020W-B	HTL1	hom	Verified	0.638338067027109	0.261626818546026	no	1269	0.283262266565361	961	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE	NUCLEUS	RSC COMPLEX	Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance	regulation of cell cycle|nucleosome disassembly|response to DNA damage stimulus|chromatin remodeling|transcription elongation from RNA polymerase II promoter	chromatin binding	RSC complex
YOR344C	YOR344C	TYE7	hom	Verified	0.638241405367008	0.261658273969438	no	1270	0.254463028943401	871	NA	FT	CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS|CHROMOSOME		Serine-rich protein that contains a basic-helix-loop-helix (bHLH) DNA binding motif; binds E-boxes of glycolytic genes and contributes to their activation; may function as a transcriptional activator in Ty1-mediated gene expression	positive regulation of glycolysis|transcription, DNA-dependent	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	nuclear chromatin|nucleus
YLL023C	YLL023C	POM33	hom	Verified	0.636054483499642	0.262370455538028	no	1271	0.252349332888986	840	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM	NUCLEAR PORE	Transmembrane nucleoporin; involved in nuclear pore complex (NPC) distribution, assembly or stabilization; highly conserved across species, orthologous to human TMEM33 and paralogous to Per33p; protein abundance increases in response to DNA replication stress	nuclear pore organization|nuclear pore complex assembly	structural constituent of nuclear pore	ribosome|integral to membrane|endoplasmic reticulum|nuclear pore
YBL102W	YBL102W	SFT2	hom	Verified	0.636019653368328	0.262381806162308	no	1272	0.280956447381803	948	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Non-essential tetra-spanning membrane protein found mostly in the late Golgi, can suppress some sed5 alleles; may be part of the transport machinery, but precise function is unknown; similar to mammalian syntaxin 5	Golgi to endosome transport	molecular_function	integral to membrane|Golgi membrane
YLR332W	YLR332W	MID2	hom	Verified	0.635886045089935	0.26242534945495	no	1273	0.279715296947363	970	NA	FT	RNA PROCESSING|SIGNALING|CELL WALL ORG/BIOGENESIS|PEROXISOME ORGANIZATION	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		O-glycosylated plasma membrane protein that acts as a sensor for cell wall integrity signaling and activates the pathway; interacts with Rom2p, a guanine nucleotide exchange factor for Rho1p, and with cell integrity pathway protein Zeo1p	UFP-specific transcription factor mRNA processing involved in endoplasmic reticulum unfolded protein response|fungal-type cell wall organization|peroxisome degradation|cell morphogenesis involved in conjugation|response to acid|response to osmotic stress	transmembrane signaling receptor activity	integral to plasma membrane|mating projection tip
YAL037C-A_p	YAL037C-A	YAL037C-A	hom	Uncharacterized	0.635853593255975	0.26243592615223	no	1274	0.265014719648498	926	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YPL191C_p	YPL191C	YPL191C	hom	Uncharacterized	0.635671742893156	0.262495198835544	no	1275	0.256350847428003	888	NA					Putative protein of unknown function; diploid deletion strain exhibits high budding index; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	biological_process	molecular_function	cytoplasm
YNR021W_p	YNR021W	YNR021W	hom	Uncharacterized	0.635475500013952	0.262559170332455	no	1276	0.251709060429835	834	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YNR021W is not an essential gene	biological_process	molecular_function	endoplasmic reticulum
YMR253C_p	YMR253C	YMR253C	hom	Uncharacterized	0.635220229329944	0.26264239572488	no	1277	0.257161930711858	920	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YMR253C is not an essential gene	biological_process	molecular_function	integral to membrane|cytoplasm
YGL252C	YGL252C	RTG2	hom	Verified	0.635001621501344	0.262713678727699	no	1278	0.280471068696373	978	NA	FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|SIGNALING|RESPONSE TO NUTRIENT LEVELS	NUCLEUS|CHROMOSOME	HISTONE ACETYLTRANSFERASE	Sensor of mitochondrial dysfunction; regulates the subcellular location of Rtg1p and Rtg3p, transcriptional activators of the retrograde (RTG) and TOR pathways; Rtg2p is inhibited by the phosphorylated form of Mks1p	maintenance of DNA trinucleotide repeats|regulation of transcription from RNA polymerase II promoter|Unknown|nitrogen catabolite regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|mitochondria-nucleus signaling pathway|transcription factor import into nucleus	RNA polymerase II transcription factor binding transcription factor activity	SLIK (SAGA-like) complex|transcriptionally active chromatin|cytoplasm
YMR035W	YMR035W	IMP2	hom	Verified	0.634524364944902	0.262869335535345	no	1279	0.23150302865893	789	NA	FT	PROTEIN LOCALIZATION|PROTEOLYSIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p	protein processing involved in protein targeting to mitochondrion	endopeptidase activity	mitochondrial inner membrane peptidase complex
YLR072W_p	YLR072W	YLR072W	hom	Uncharacterized	0.633846721375433	0.263090429379316	no	1280	0.267063581354896	919	NA	FT		ENDOMEMBRANE SYSTEM		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YLR072W is not an esssential gene	biological_process	molecular_function	cytoplasm
YDR043C	YDR043C	NRG1	hom	Verified	0.633220763262047	0.263294744275619	no	1281	0.239110026404729	824	NA	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Transcriptional repressor; recruits the Cyc8p-Tup1p complex to promoters; mediates glucose repression and negatively regulates a variety of processes including filamentous growth and alkaline pH response; NRG1 has a paralog, NRG2, that arose from the whole genome duplication	negative regulation of transcription from RNA polymerase II promoter by glucose|cellular hyperosmotic salinity response|biofilm formation|negative regulation of transcription from RNA polymerase II promoter|pseudohyphal growth|Unknown	RNA polymerase II repressing transcription factor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription	nucleus
YJR096W	YJR096W	YJR096W	hom	Verified	0.63260354372696	0.263496286181903	no	1282	0.25935875942762	899	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		Putative xylose and arabinose reductase; member of the aldo-keto reductase (AKR) family; GFP-fusion protein is induced in response to the DNA-damaging agent MMS	cellular response to oxidative stress|D-xylose catabolic process|arabinose catabolic process	alditol:NADP+ 1-oxidoreductase activity|aldo-keto reductase (NADP) activity	nucleus|cytoplasm
YMR109W	YMR109W	MYO5	hom	Verified	0.631993804508107	0.263695462809421	no	1283	0.250343477002786	843	NA	FT	VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS|CELL DIVISION	SITE OF POLARIZED GROWTH|CYTOSKELETON		One of two type I myosins; contains proline-rich tail homology 2 (TH2) and SH3 domains; MYO5 deletion has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization	bipolar cellular bud site selection|endocytosis|exocytosis|fungal-type cell wall organization|response to salt stress|receptor-mediated endocytosis|actin cortical patch localization|response to osmotic stress	microfilament motor activity	mating projection tip|actin cortical patch
YMR294W-A_d	YMR294W-A	YMR294W-A	hom	Dubious	0.631784007380318	0.263764012622321	no	1284	0.28425560105968	952	NA					Dubious open reading frame unlikely to encode a functional protein, substantially overlaps YMR295C; deletion causes sensitivity to unfolded protein response-inducing agents	Unknown	Unknown	Unknown
YHR136C	YHR136C	SPL2	hom	Verified	0.631382221233493	0.263895318930164	no	1285	0.279116766303754	936	NA					Protein with similarity to cyclin-dependent kinase inhibitors; downregulates low-affinity phosphate transport during phosphate limitation; overproduction suppresses a plc1 null mutation; GFP-fusion protein localizes to the cytoplasm	response to temperature stimulus	enzyme inhibitor activity	cytoplasm
YGR183C	YGR183C	QCR9	hom	Verified	0.631273324310189	0.263930912886771	no	1286	0.265987318813472	908	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex	iron-sulfur cluster assembly|mitochondrial electron transport, ubiquinol to cytochrome c|aerobic respiration	ubiquinol-cytochrome-c reductase activity	mitochondrion|integral to membrane|mitochondrial respiratory chain complex III
YDR264C	YDR264C	AKR1	hom	Verified	0.6306443164393	0.264136557748804	no	1287	0.393316510809556	1299	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Palmitoyl transferase involved in protein palmitoylation; acts as a negative regulator of pheromone response pathway; required for endocytosis of pheromone receptors; involved in cell shape control; contains ankyrin repeats; AKR1 has a paralog, AKR2, that arose from the whole genome duplication	protein targeting to membrane|regulation of endocytosis|regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion|protein palmitoylation	palmitoyltransferase activity	integral to membrane|Golgi apparatus|membrane
YJL080C	YJL080C	SCP160	hom	Verified	0.630367729748666	0.264227009524426	no	1288	0.249697796696444	904	NA	FT	CELL CYCLE|SIGNALING|RNA LOCALIZATION|CHROMOSOME SEGREGATION|GENE SILENCING	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM		Essential RNA-binding G protein effector of mating response pathway, mainly associated with nuclear envelope and ER, interacts in mRNA-dependent manner with translating ribosomes via multiple KH domains, similar to vertebrate vigilins	meiotic telomere clustering|pheromone-dependent signal transduction involved in conjugation with cellular fusion|chromosome segregation|intracellular mRNA localization|chromatin silencing at silent mating-type cassette|chromatin silencing at telomere	G-protein alpha-subunit binding|RNA binding	endoplasmic reticulum membrane|polysome|nuclear outer membrane-endoplasmic reticulum membrane network
YHL016C	YHL016C	DUR3	hom	Verified	0.63004849391789	0.264331428398286	no	1289	0.241339405295417	817	NA	FT		PLASMA MEMBRANE		Plasma membrane transporter for both urea and polyamines, expression is highly sensitive to nitrogen catabolite repression and induced by allophanate, the last intermediate of the allantoin degradative pathway	urea transport|spermidine transport|putrescine transport|urea catabolic process	urea transmembrane transporter activity|spermidine transmembrane transporter activity|putrescine transmembrane transporter activity	integral to membrane|plasma membrane
YOR195W	YOR195W	SLK19	hom	Verified	0.629518007843919	0.264504991580398	no	1290	0.222595212120243	774	NA	FT	CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME|CYTOSKELETON	KINETOCHORE	Kinetochore-associated protein required for normal segregation of chromosomes in meiosis and mitosis; component of the FEAR regulatory network, which promotes Cdc14p release from the nucleolus during anaphase; potential Cdc28p substrate	meiosis|mitotic spindle organization in nucleus	molecular_function	spindle midzone|condensed nuclear chromosome kinetochore|kinetochore|spindle
YDL096C_d	YDL096C	OPI6	hom	Dubious	0.628654818046384	0.264787531877517	no	1291	0.251820174141143	862	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene PMT1/YDL095W; YDL096C is not essential	Unknown	Unknown	Unknown
YER144C	YER144C	UBP5	hom	Verified	0.628055066226164	0.264983933651376	no	1292	0.266063651921154	925	NA	FT	PROTEOLYSIS	SITE OF POLARIZED GROWTH		Putative ubiquitin-specific protease, closest paralog of Doa4p but has no functional overlap; concentrates at the bud neck	protein deubiquitination	ubiquitin-specific protease activity	incipient cellular bud site|cellular bud neck
YDR202C	YDR202C	RAV2	hom	Verified	0.627998597388009	0.265002429412269	no	1293	0.28738809916635	994	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|ION HOMEOSTASIS			Subunit of RAVE (Rav1p, Rav2p, Skp1p), a complex that associates with the V1 domain of the vacuolar membrane (H+)-ATPase (V-ATPase) and promotes assembly and reassembly of the holoenzyme	vacuolar acidification|regulation of protein complex assembly	molecular_function	RAVE complex
YDR517W	YDR517W	GRH1	hom	Verified	0.627907210029153	0.265032363748939	no	1294	0.244345763506407	848	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Acetylated cis-Golgi protein, involved in ER to Golgi transport; homolog of human GRASP65; forms a complex with the coiled-coil protein Bug1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes; protein abundance increases in response to DNA replication stress	protein secretion|ER to Golgi vesicle-mediated transport|Golgi organization	molecular_function	COPII vesicle coat|cis-Golgi network|cytoplasm
YOL163W_p	YOL163W	YOL163W	hom	Uncharacterized	0.627762037118754	0.265079919314396	no	1295	0.249904394543068	850	NA					Putative protein of unknown function; member of the Dal5p subfamily of the major facilitator family	transmembrane transport	transmembrane transporter activity	integral to membrane|membrane
YMR194C-B	YMR194C-B	CMC4	hom	Verified	0.627666614620391	0.265111180061102	no	1296	0.248900125048522	829	NA	FT		MITOCHONDRION		Protein that localizes to the mitochondrial intermembrane space via the Mia40p-Erv1p system; contains twin cysteine-x(9)-cysteine motifs	biological_process	molecular_function	mitochondrial intermembrane space
YDR533C	YDR533C	HSP31	hom	Verified	0.626896912769725	0.265363405548637	no	1297	0.285824753860041	992	NA	FT	PROTEOLYSIS			Possible chaperone and cysteine protease; has similarity to E. coli Hsp31; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease; exists as a dimer and contains a putative metal-binding site; protein abundance increases in response to DNA replication stress	biological_process	unfolded protein binding|cysteine-type peptidase activity	cellular_component
YLR179C	YLR179C	YLR179C	hom	Verified	0.626717426181512	0.265422239455721	no	1298	0.227954102715998	766	NA	FT		NUCLEUS		Protein of unknown function with similarity to Tfs1p; transcription is activated by paralogous proteins Yrm1p and Yrr1p along with proteins involved in multidrug resistance; GFP-tagged protein localizes to the cytoplasm and nucleus	biological_process	molecular_function	nucleus|cytoplasm
YDR368W	YDR368W	YPR1	hom	Verified	0.626377652904105	0.265533631857469	no	1299	0.263056627120264	911	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		NADPH-dependent aldo-keto reductase; reduces multiple substrates including 2-methylbutyraldehyde and D,L-glyceraldehyde, expression is induced by osmotic and oxidative stress; functionally redundant with other aldo-keto reductases; protein abundance increases in response to DNA replication stress; YPR1 has a paralog, GCY1, that arose from the whole genome duplication	cellular response to oxidative stress|D-xylose catabolic process|arabinose catabolic process	glucose 1-dehydrogenase (NADP+) activity|alditol:NADP+ 1-oxidoreductase activity|carbonyl reductase (NADPH) activity	nucleus|cytoplasm
YOR061W	YOR061W	CKA2	hom	Verified	0.62493806681479	0.266005853496091	no	1300	0.284925193011319	996	NA	FF|FT	RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION	NUCLEUS		Alpha' catalytic subunit of casein kinase 2 (CK2); CK2 is a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases; protein abundance increases in response to DNA replication stress; regulates Fkh1p-mediated donor preference during mating-type switching	regulation of transcription from RNA polymerase I promoter|chronological cell aging|protein phosphorylation|regulation of transcription from RNA polymerase III promoter|response to DNA damage stimulus	protein serine/threonine kinase activity	protein kinase CK2 complex|UTP-C complex
YBR097W	YBR097W	VPS15	hom	Verified	0.624650712423625	0.266100164107968	no	1301	0.261773373371874	864	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING|PROTEIN PHOSPHORYLATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS|PEROXISOME ORGANIZATION	ENDOMEMBRANE SYSTEM|MITOCHONDRION|GOLGI APPARATUS		Serine/threonine protein kinase involved in vacuolar protein sorting; functions as a membrane-associated complex with Vps34p; active form recruits Vps34p to the Golgi membrane; interacts with the GDP-bound form of Gpa1p; myristoylated; a fraction is localized, with Vps34p, to nuclear pores at nucleus-vacuole junctions and may facilitate transcription elongation for genes positioned at the nuclear periphery	protein retention in Golgi apparatus|vacuole inheritance|peroxisome degradation|protein phosphorylation|macroautophagy|inositol lipid-mediated signaling|late endosome to vacuole transport|protein targeting to vacuole	ubiquitin binding|protein serine/threonine kinase activity	mitochondrion|phosphatidylinositol 3-kinase complex I|phosphatidylinositol 3-kinase complex II|Golgi membrane
YHR061C	YHR061C	GIC1	hom	Verified	0.624622965287886	0.266109271701274	no	1302	0.261027093258579	857	NA	FT	CELL CYCLE|SIGNALING|CELL DIVISION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Protein involved in initiation of budding and cellular polarization; interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain; relocalizes from bud neck to nucleus upon DNA replication stress	regulation of exit from mitosis|establishment of cell polarity|axial cellular bud site selection|Rho protein signal transduction	Rho GTPase binding|Rho GTPase activator activity	incipient cellular bud site|actin cap|mating projection tip|cellular bud neck|cellular bud tip
YDR326C	YDR326C	YSP2	hom	Verified	0.624163205076962	0.266260204269945	no	1303	0.272388068724132	972	NA	FT		MITOCHONDRION		Protein involved in programmed cell death; mutant shows resistance to cell death induced by amiodarone or intracellular acidification; YSP2 has a paralog, YHR080C, that arose from the whole genome duplication	apoptotic process	molecular_function	mitochondrion
YAR023C_p	YAR023C	YAR023C	hom	Uncharacterized	0.623928413859463	0.266337299511614	no	1304	0.266973551600168	925	NA					Putative integral membrane protein, member of DUP240 gene family	biological_process	molecular_function	cellular_component
YDR418W	YDR418W	RPL12B	hom	Verified	0.62346381050961	0.266489888365014	no	1305	0.248938787932229	843	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L12B; rpl12a rpl12b double mutant exhibits slow growth and slow translation; homologous to mammalian ribosomal protein L12 and bacterial L11; RPL12B has a paralog, RPL12A, that arose from the whole genome duplication	cytoplasmic translation|ribosomal large subunit assembly	structural constituent of ribosome	cytosolic large ribosomal subunit
YDL242W_d	YDL242W	YDL242W	hom	Dubious	0.623327216093962	0.266534758236173	no	1306	0.24408542164018	810	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YBR058C	YBR058C	UBP14	hom	Verified	0.623269303978347	0.266553782928272	no	1307	0.255935390912562	885	NA	FT	KETONE METABOLISM|CARBOHYDRATE METABOLISM|PROTEOLYSIS	NUCLEUS		Ubiquitin-specific protease that specifically disassembles unanchored ubiquitin chains; involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; similar to human isopeptidase T	protein deubiquitination|negative regulation of gluconeogenesis|proteasomal ubiquitin-dependent protein catabolic process	ubiquitin-specific protease activity	cytoplasm
YOR087W	YOR087W	YVC1	hom	Verified	0.623234612776674	0.26656517965364	no	1308	0.257858419576162	824	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Vacuolar cation channel, mediates release of Ca(2+) from the vacuole in response to hyperosmotic shock	cellular cation homeostasis	voltage-gated ion channel activity|calcium activated cation channel activity|sodium channel activity|calcium channel activity|potassium channel activity	fungal-type vacuole membrane|fungal-type vacuole
YOL083W	YOL083W	ATG34	hom	Verified	0.62289092567075	0.266678100773909	no	1309	0.249692924558911	811	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS			Receptor protein involved in selective autophagy during starvation; specifically involved in the transport of cargo protein alpha-mannosidase (Ams1p); Atg19p paralog	protein complex assembly|protein complex localization	protein binding, bridging	CVT complex
YMR010W_p	YMR010W	YMR010W	hom	Uncharacterized	0.622869944360569	0.266684995132617	no	1310	0.264172627405273	875	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR010W is not an essential gene; YMR010W mRNA is transcribed with ADI1	biological_process	molecular_function	integral to membrane|cytoplasm
YOR125C	YOR125C	CAT5	hom	Verified	0.622803304255662	0.266706893351599	no	1311	0.256410798725741	883	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|COFACTOR METABOLISM	MITOCHONDRION		Protein required for ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes; required for gluconeogenic gene activation	ubiquinone biosynthetic process	monooxygenase activity	mitochondrion|mitochondrial inner membrane
YMR170C	YMR170C	ALD2	hom	Verified	0.622115480341874	0.266932968277102	no	1312	0.258070684068986	896	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS			Cytoplasmic aldehyde dehydrogenase, involved in ethanol oxidation and beta-alanine biosynthesis; uses NAD+ as the preferred coenzyme; expression is stress induced and glucose repressed; very similar to Ald3p	cellular aldehyde metabolic process|beta-alanine biosynthetic process|polyamine catabolic process	aldehyde dehydrogenase (NAD) activity	cytoplasm
YJR091C	YJR091C	JSN1	hom	Verified	0.621873240401099	0.267012611082048	no	1313	0.237523754708183	798	NA	FT	PROTEIN LOCALIZATION	MITOCHONDRION		Member of the Puf family of RNA-binding proteins, interacts with mRNAs encoding membrane-associated proteins; involved in localizing the Arp2/3 complex to mitochondria; overexpression causes increased sensitivity to benomyl	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|cellular protein complex localization|establishment of mitochondrion localization	mRNA binding	external side of mitochondrial outer membrane
YNL255C	YNL255C	GIS2	hom	Verified	0.62140763319048	0.267165725493307	no	1314	0.265305116714781	914	NA	FT	TRANSLATION		RIBOSOME	Translational activator for mRNAs with internal ribosome entry sites; associates with polysomes and binds to a specific subset of mRNAs; localizes to RNA processing bodies (P bodies) and to stress granules; may have a role in translation regulation under stress conditions; ortholog of human ZNF9/CNBP, a gene involved in myotonic dystrophy type 2	positive regulation of translation	mRNA binding|translation regulator activity|single-stranded DNA binding	polysomal ribosome|cytoplasm
YKL087C	YKL087C	CYT2	hom	Verified	0.621394511132003	0.267170041309624	no	1315	0.267437791414805	931	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS	MITOCHONDRION		Cytochrome c1 heme lyase, involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1	cytochrome c-heme linkage	holocytochrome-c synthase activity	mitochondrion|mitochondrial intermembrane space
YIL157C	YIL157C	COA1	hom	Verified	0.62105018344104	0.26728330250958	no	1316	0.269323849664967	939	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial inner membrane protein required for assembly of the cytochrome c oxidase complex (complex IV); interacts with complex IV assembly factor Shy1p during the early stages of assembly	mitochondrial respiratory chain complex IV assembly	molecular_function	integral to mitochondrial membrane|mitochondrion|integral to mitochondrial inner membrane
YBR215W	YBR215W	HPC2	hom	Verified	0.621000229863181	0.267299735968662	no	1317	0.266619027549831	931	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION	NUCLEUS		Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; mutants display synthetic defects with subunits of FACT, a complex that allows passage of RNA Pol II through nucleosomes	DNA replication-independent nucleosome assembly|regulation of transcription involved in G1/S phase of mitotic cell cycle|transcription elongation from RNA polymerase II promoter	nucleosome binding|DNA binding	HIR complex|nucleus
YGL219C	YGL219C	MDM34	hom	Verified	0.620525052656316	0.267456082693205	no	1318	0.30760999781855	1037	NA	FT	MITOCHONDRION ORGANIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION		Mitochondrial component of the ERMES complex that links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth	mitochondrion organization|phospholipid transport	molecular_function	mitochondrial outer membrane|ERMES complex|mitochondrion|cytoplasm
YPR192W	YPR192W	AQY1	hom	Verified	0.620400269864154	0.267497147401452	no	1319	0.243927974870731	853	NA	FT		PLASMA MEMBRANE		Spore-specific water channel that mediates the transport of water across cell membranes, developmentally controlled; may play a role in spore maturation, probably by allowing water outflow, may be involved in freeze tolerance	ascospore formation|water transport	water channel activity	integral to membrane|plasma membrane
YLR107W	YLR107W	REX3	hom	Verified	0.619812399302572	0.267690652200828	no	1320	0.254727352445397	884	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		RNA exonuclease; required for maturation of the RNA component of RNase MRP; functions redundantly with Rnh70p and Rex2p in processing of U5 snRNA and RNase P RNA; member of RNase D family of exonucleases	U5 snRNA 3'-end processing|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|ncRNA 3'-end processing	3'-5'-exoribonuclease activity|3'-5' exonuclease activity	nucleus|cytoplasm
YOR009W	YOR009W	TIR4	hom	Verified	0.619731689453339	0.267717224343218	no	1321	0.263779709318675	911	NA	FT	CELL WALL ORG/BIOGENESIS			Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expressed under anaerobic conditions and required for anaerobic growth; transcription is also induced by cold shock	biological_process	molecular_function	fungal-type cell wall
YIR028W	YIR028W	DAL4	hom	Verified	0.619504899833226	0.267791897512953	no	1322	0.262765130522015	897	NA					Allantoin permease; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation	allantoin catabolic process|allantoin transport	allantoin uptake transmembrane transporter activity	integral to membrane|membrane
YLR423C	YLR423C	ATG17	hom	Verified	0.619309656530758	0.267856192088335	no	1323	0.281518329238298	963	NA	FT	MEMBRANE ORGANIZATION|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS|PEROXISOME ORGANIZATION			Scaffold protein responsible for phagophore assembly site organization; regulatory subunit of an autophagy-specific complex that includes Atg1p and Atg13p; stimulates Atg1p kinase activity; human ortholog RB1CC1/FIP200 interacts with p53, which inhibits autophagy in human cells	piecemeal microautophagy of nucleus|mitochondrion degradation|peroxisome degradation|activation of protein kinase activity|autophagic vacuole assembly	protein kinase activator activity|protein complex scaffold	pre-autophagosomal structure|Atg1p signaling complex
YDR237W	YDR237W	MRPL7	hom	Verified	0.618903202200382	0.267990064427277	no	1324	0.282027118264476	997	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit; MRPL7 produces both YmL5 and YmL7, which are two different modified forms of the same protein	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YIR019C	YIR019C	FLO11	hom	Verified	0.618808686359664	0.268021199582499	no	1325	0.250164128495252	855	NA	FT		SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		GPI-anchored cell surface glycoprotein (flocculin); required for pseudohyphal formation, invasive growth, flocculation, and biofilms; transcriptionally regulated by the MAPK pathway (via Ste12p and Tec1p) and the cAMP pathway (via Flo8p); required for the formation of fibrous interconnections between cells in a colony of a wild S. cerevisiae strain	cell-cell adhesion|biofilm formation|pseudohyphal growth|filamentous growth|flocculation|invasive growth in response to glucose limitation	molecular_function	extracellular region|plasma membrane|cellular bud neck
YPR063C_p	YPR063C	YPR063C	hom	Uncharacterized	0.61831050175633	0.268185340312968	no	1326	0.275892668469899	942	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		ER-localized protein of unknown function	biological_process	molecular_function	endoplasmic reticulum
YNL253W	YNL253W	TEX1	hom	Verified	0.618232287682657	0.268211114701581	no	1327	0.254838917570859	854	NA	FT	RNA LOCALIZATION	NUCLEUS		Protein involved in mRNA export, component of the transcription export (TREX) complex	mRNA export from nucleus	molecular_function	transcription export complex
YBL079W	YBL079W	NUP170	hom	Verified	0.618193516055849	0.268223891828105	no	1328	0.286766880309123	969	NA	FF|FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA LOCALIZATION|CHROMOSOME SEGREGATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC assembly and nucleocytoplasmic transport; both Nup170p and NUP157p are similar to human Nup155p; NUP170 has a paralog, NUP157, that arose from the whole genome duplication	nucleocytoplasmic transport|chromosome segregation|protein targeting to nuclear inner membrane|mitotic cell cycle spindle assembly checkpoint|nuclear pore complex assembly	structural constituent of nuclear pore	integral to membrane|nuclear pore|nuclear pore inner ring
YER090W	YER090W	TRP2	hom	Verified	0.618167175434893	0.268232572511585	no	1329	0.439100178305155	1444	NA	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM			Anthranilate synthase, catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p	tryptophan biosynthetic process	anthranilate synthase activity	anthranilate synthase complex|cytoplasm
YJL165C	YJL165C	HAL5	hom	Verified	0.61808882377262	0.268258394529596	no	1330	0.247544773753947	820	NA	FT	PROTEIN LOCALIZATION|ION HOMEOSTASIS|PROTEIN PHOSPHORYLATION|ION HOMEOSTASIS			Putative protein kinase; overexpression increases sodium and lithium tolerance, whereas gene disruption increases cation and low pH sensitivity and impairs potassium uptake, suggesting a role in regulation of Trk1p and/or Trk2p transporters; HAL5 has a paralog, KKQ8, that arose from the whole genome duplication	cellular cation homeostasis|protein phosphorylation|cellular protein localization|protein dephosphorylation	protein kinase activity	cellular_component
YLL009C	YLL009C	COX17	hom	Verified	0.617675889768382	0.268394504061489	no	1331	0.257449425427403	856	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS	MITOCHONDRION		Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs	mitochondrial respiratory chain complex IV assembly|intracellular copper ion transport	copper chaperone activity	cytosol|mitochondrion|mitochondrial intermembrane space
YLL057C	YLL057C	JLP1	hom	Verified	0.616614929172128	0.268744372505356	no	1332	0.240750487310836	805	NA	FT	OXIDATION-REDUCTION PROCESS			Fe(II)-dependent sulfonate/alpha-ketoglutarate dioxygenase, involved in sulfonate catabolism for use as a sulfur source; contains sequence that resembles a J domain (typified by the E. coli DnaJ protein); induced by sulphur starvation	sulfur compound catabolic process	sulfonate dioxygenase activity	cellular_component
YGR124W	YGR124W	ASN2	hom	Verified	0.616321414766367	0.268841203940208	no	1333	0.262053964727771	897	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Asparagine synthetase; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway; ASN2 has a paralog, ASN1, that arose from the whole genome duplication	asparagine biosynthetic process	asparagine synthase (glutamine-hydrolyzing) activity	cytoplasm
YBL009W	YBL009W	ALK2	hom	Verified	0.615946210710145	0.268965010587605	no	1334	0.258828203691404	892	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION			Protein kinase; accumulation and phosphorylation are periodic during the cell cycle; phosphorylated in response to DNA damage; contains characteristic motifs for degradation via the APC pathway; ALK2 has a paralog, ALK1, that arose from the whole genome duplication; similar to mammalian haspins	meiosis|mitosis|protein phosphorylation	protein serine/threonine kinase activity|protein kinase activity	cellular_component
YBR275C	YBR275C	RIF1	hom	Verified	0.615549181067622	0.269096050217329	no	1335	0.253039588210003	848	NA	FT	CELL CYCLE|GENE SILENCING	NUCLEUS|CHROMOSOME		Protein that binds to the Rap1p C-terminus and acts synergistically with Rif2p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation	telomere capping|telomere maintenance|chromatin silencing at silent mating-type cassette	telomeric DNA binding	nuclear telomere cap complex
YDR049W	YDR049W	VMS1	hom	Verified	0.615298027512808	0.269178959985257	no	1336	0.264011810049288	905	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION		Component of a Cdc48p-complex involved in protein quality control; exhibits cytosolic and ER-membrane localization, with Cdc48p, during normal growth, and contributes to ER-associated degradation (ERAD) of specific substrates at a step after their ubiquitination; forms a mitochondrially-associated complex with Cdc48p and Npl4p under oxidative stress that is required for ubiquitin-mediated mitochondria-associated protein degradation (MAD); conserved in C. elegans and humans	ER-associated protein catabolic process|mitochondria-associated protein catabolic process|nucleus-associated proteasomal ubiquitin-dependent protein catabolic process	molecular_function	cytosol|mitochondrion|endoplasmic reticulum membrane|Cdc48p-Npl4p-Vms1p AAA ATPase complex|cytoplasm
YKL072W	YKL072W	STB6	hom	Verified	0.615269549103245	0.269188361968381	no	1337	0.22360611649432	756	NA					Protein that binds Sin3p in a two-hybrid assay	biological_process	molecular_function	cellular_component
YKR104W	YKR104W	YKR104W	hom	Verified	0.614794014865609	0.269345381200803	no	1338	0.264501384921027	909	NA	FT	NUCLEOTIDE METABOLISM			Putative transporter of the multidrug resistance-associated protein (MRP) subfamily; contains a stop codon in S288C; adjacent ORFs YKR103W and YKR104W are merged in different strain backgrounds	transport	ATPase activity, coupled to transmembrane movement of substances	integral to membrane|membrane
YDL146W	YDL146W	LDB17	hom	Verified	0.614224864522291	0.269533372401257	no	1339	0.249568628338001	867	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Protein involved in the regulation of endocytosis; transiently recruited to actin cortical patches in a SLA1-dependent manner after late coat component assembly; GFP-fusion protein localizes to the periphery, cytoplasm, bud, and bud neck	endocytosis	molecular_function	cellular bud|cellular bud neck|cytoplasm|actin cortical patch
YDR079C-A	YDR079C-A	TFB5	hom	Verified	0.614066045697539	0.269585842225692	no	1340	0.268182260367675	954	NA	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION	NUCLEUS	RNA POL II, HOLOENZYME	Component of the RNA polymerase II general transcription and DNA repair factor TFIIH; involved in transcription initiation and in nucleotide-excision repair; homolog of Chlamydomonas reinhardtii REX1-S protein involved in DNA repair	phosphorylation of RNA polymerase II C-terminal domain|nucleotide-excision repair|transcription from RNA polymerase II promoter	core RNA polymerase binding transcription factor activity	core TFIIH complex|holo TFIIH complex|nucleus
YPL119C	YPL119C	DBP1	hom	Verified	0.613541582376363	0.269759148325306	no	1341	0.255177182930825	856	NA	FT	TRANSLATION			Putative ATP-dependent RNA helicase of the DEAD-box protein family; mutants show reduced stability of the 40S ribosomal subunit scanning through 5' untranslated regions of mRNAs; protein abundance increases in response to DNA replication stress	translational initiation	RNA helicase activity	cytoplasm
YJL159W	YJL159W	HSP150	hom	Verified	0.613074710463412	0.269913470577625	no	1342	0.251500382986607	831	NA	FT	CELL WALL ORG/BIOGENESIS			O-mannosylated heat shock protein; secreted and covalently attached to the cell wall via beta-1,3-glucan and disulfide bridges; required for cell wall stability; induced by heat shock, oxidative stress, and nitrogen limitation; HSP150 has a paralog, PIR3, that arose from the whole genome duplication	fungal-type cell wall organization	structural constituent of cell wall|ATPase activity	fungal-type cell wall|extracellular region
YJL037W	YJL037W	IRC18	hom	Verified	0.612945577055713	0.269956162801218	no	1343	0.275913219514886	994	NA					Putative protein of unknown function; expression induced in respiratory-deficient cells and in carbon-limited chemostat cultures; similar to adjacent ORF, YJL038C; null mutant displays increased levels of spontaneous Rad52p foci	biological_process	molecular_function	cellular_component
YBR151W	YBR151W	APD1	hom	Verified	0.612898891712697	0.26997159806728	no	1344	0.264452231527796	924	NA	FT		NUCLEUS		Protein of unknown function, required for normal localization of actin patches and for normal tolerance of sodium ions and hydrogen peroxide; localizes to both cytoplasm and nucleus	biological_process	molecular_function	nucleus|cytoplasm
YFL049W	YFL049W	SWP82	hom	Verified	0.612644411003148	0.270055743105251	no	1345	0.256474143130317	868	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION	NUCLEUS	RSC COMPLEX	Member of the SWI/SNF chromatin remodeling complex; has an as yet unidentified role in the complex; has identifiable counterparts in closely related yeast species; abundantly expressed in many growth conditions; paralog of Npl6p; relocates to the cytosol under hypoxic conditions	positive regulation of transcription from RNA polymerase II promoter	molecular_function	SWI/SNF complex|nucleus
YIL134C-A_p	YIL134C-A	YIL134C-A	hom	Uncharacterized	0.612276539264001	0.270177404518957	no	1346	0.262844450361428	907	NA					Putative protein of unknown function; identified by fungal homology and RT-PCR	biological_process	molecular_function	cellular_component
YOL118C_d	YOL118C	YOL118C	hom	Dubious	0.612065098827855	0.270247343855312	no	1347	0.288914737103149	960	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YCR020C-A	YCR020C-A	MAK31	hom	Verified	0.611290111596852	0.270503768094673	no	1348	0.253556424435782	864	NA					Non-catalytic subunit of N-terminal acetyltransferase of the NatC type; required for replication of dsRNA virus; member of the Sm protein family	N-terminal protein amino acid acetylation	peptide alpha-N-acetyltransferase activity	NatC complex
YBL008W-A_p	YBL008W-A	YBL008W-A	hom	Uncharacterized	0.61052393508959	0.270757396525777	no	1349	0.263892488589342	915	NA					Putative protein of unknown function; identified by fungal homology and RT-PCR	biological_process	molecular_function	cellular_component
YMR098C	YMR098C	ATP25	hom	Verified	0.610281193493987	0.27083777635826	no	1350	0.289821135141209	990	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial protein required for the stability of Oli1p (Atp9p) mRNA and for the Oli1p ring formation; YMR098C is not an essential gene	mRNA stabilization|mitochondrial proton-transporting ATP synthase complex assembly	molecular_function	mitochondrion|mitochondrial inner membrane
YOR066W	YOR066W	MSA1	hom	Verified	0.609570198268759	0.271073279084677	no	1351	0.267482766460266	929	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE	NUCLEUS		Activator of G1-specific transcription factors, MBF and SBF; involved in regulation of the timing of G1-specific gene transcription and cell cycle initiation; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation	G1/S transition of mitotic cell cycle|regulation of transcription involved in G1 phase of mitotic cell cycle|regulation of cell size	molecular_function	nucleus|cytoplasm
YLR410W	YLR410W	VIP1	hom	Verified	0.609567024195006	0.271074330661085	no	1352	0.249600373113238	851	NA	FT		CYTOSKELETON		Inositol hexakisphosphate (IP6) and inositol heptakisphosphate (IP7) kinase; IP7 production is important for phosphate signaling; involved in cortical actin cytoskeleton function, and invasive pseudohyphal growth analogous to S. pombe asp1	inositol phosphate biosynthetic process	inositol hexakisphosphate 1-kinase activity|inositol hexakisphosphate 3-kinase activity|inositol heptakisphosphate kinase activity|inositol hexakisphosphate 4-kinase activity|inositol hexakisphosphate 6-kinase activity	cytoplasm
YFL012W_p	YFL012W	YFL012W	hom	Uncharacterized	0.608551818193255	0.271410774614846	no	1353	0.292406970640301	990	NA					Putative protein of unknown function; transcribed during sporulation; null mutant exhibits increased resistance to rapamycin	biological_process	molecular_function	cellular_component
YPR195C_d	YPR195C	YPR195C	hom	Dubious	0.608149459091121	0.271544175823197	no	1354	0.257797040904628	895	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YBL027W	YBL027W	RPL19B	hom	Verified	0.606490584418445	0.272094516408982	no	1355	0.256037141219309	884	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L19B; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal; homologous to mammalian ribosomal protein L19, no bacterial homolog; RPL19B has a paralog, RPL19A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YMR124W_p	YMR124W	YMR124W	hom	Uncharacterized	0.606058171796131	0.272238062679767	no	1356	0.258307025012778	887	NA					Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene; predicted to have a role in organelle organization	biological_process	molecular_function	cytoplasm
YNL213C	YNL213C	RRG9	hom	Verified	0.606030626056529	0.272247208202505	no	1357	0.285746969536548	983	NA	FT	MITOCHONDRION ORGANIZATION	MITOCHONDRION		Protein of unknown function; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	mitochondrion organization|mitochondrial genome maintenance	molecular_function	mitochondrion
YMR136W	YMR136W	GAT2	hom	Verified	0.60547728040897	0.272430958063178	no	1358	0.271576503941367	897	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Protein containing GATA family zinc finger motifs; similar to Gln3p and Dal80p; expression repressed by leucine	regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding RNA polymerase II transcription factor activity	nucleus
YBR092C	YBR092C	PHO3	hom	Verified	0.605383427549316	0.272462129953667	no	1359	0.258220599455875	882	NA					Constitutively expressed acid phosphatase similar to Pho5p; brought to the cell surface by transport vesicles; hydrolyzes thiamin phosphates in the periplasmic space, increasing cellular thiamin uptake; expression is repressed by thiamin	phosphate-containing compound metabolic process|thiamine-containing compound metabolic process	acid phosphatase activity	cell wall-bounded periplasmic space
YOL053W	YOL053W	AIM39	hom	Verified	0.605271104368173	0.272499438826615	no	1360	0.240186289385771	804	NA	FT		MITOCHONDRION		Putative protein of unknown function; null mutant displays elevated frequency of mitochondrial genome loss	biological_process	molecular_function	cellular_component
YFR043C	YFR043C	IRC6	hom	Verified	0.604897666600575	0.272623496836452	no	1361	0.273791653514547	940	NA					Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci	biological_process	molecular_function	cellular_component
YML012W	YML012W	ERV25	hom	Verified	0.604237271010993	0.272842952358011	no	1362	0.255977925688199	916	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Protein that forms a heterotrimeric complex with Erp1, Erp2p, and Emp24, member of the p24 family involved in endoplasmic reticulum to Golgi transport	ER to Golgi vesicle-mediated transport	molecular_function	ER to Golgi transport vesicle
YKL086W	YKL086W	SRX1	hom	Verified	0.604229423456313	0.272845560699241	no	1363	0.266589167032956	911	NA	FT	OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		Sulfiredoxin; contributes to oxidative stress resistance by reducing cysteine-sulfinic acid groups in the peroxiredoxin Tsa1p, which is formed upon exposure to oxidants; conserved in higher eukaryotes; protein abundance increases in response to DNA replication stress	cellular response to oxidative stress	sulfiredoxin activity	nucleus|cytoplasm
YPR106W	YPR106W	ISR1	hom	Verified	0.604029053922126	0.272912162973824	no	1364	0.264026642940451	886	NA	FT	PROTEIN PHOSPHORYLATION			Predicted protein kinase, overexpression causes sensitivity to staurosporine, which is a potent inhibitor of protein kinase C	biological_process	protein kinase activity	cellular_component
YPL167C	YPL167C	REV3	hom	Verified	0.603902467844927	0.272954243988247	no	1365	0.274945093841918	934	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS|MITOCHONDRION|CHROMOSOME		Catalytic subunit of DNA polymerase zeta, involved in translesion synthesis during post-replication repair; required for mutagenesis induced by DNA damage; involved in double-strand break repair	error-prone translesion synthesis|error-free translesion synthesis	DNA-directed DNA polymerase activity	nuclear chromatin|mitochondrion|zeta DNA polymerase complex
YPL244C	YPL244C	HUT1	hom	Verified	0.603379358827755	0.273128175249623	no	1366	0.267055620713894	930	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein with a role in UDP-galactose transport to the Golgi lumen, has similarity to human UDP-galactose transporter UGTrel1, exhibits a genetic interaction with S. cerevisiae ERO1	UDP-galactose transport|UDP-glucose transport	UDP-galactose transmembrane transporter activity	integral to membrane
YKR055W	YKR055W	RHO4	hom	Verified	0.6028473133081	0.273305134177572	no	1367	0.265361759791613	946	NA	FT	SIGNALING|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely to be involved in the establishment of cell polarity	positive regulation of formin-nucleated actin cable assembly|maintenance of cell polarity|regulation of formin-nucleated actin cable assembly	GTPase activity	incipient cellular bud site|plasma membrane|cellular bud neck
YLR307W	YLR307W	CDA1	hom	Verified	0.602787626158714	0.27332498973144	no	1368	0.244341763813497	829	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM			Chitin deacetylase, together with Cda2p involved in the biosynthesis ascospore wall component, chitosan; required for proper rigidity of the ascospore wall	ascospore wall assembly	chitin deacetylase activity	chitosan layer of spore wall
YLR081W	YLR081W	GAL2	hom	Verified	0.602646353902936	0.273371988269771	no	1369	0.25417776370248	878	NA	FT	CARBOHYDRATE METABOLISM	PLASMA MEMBRANE		Galactose permease, required for utilization of galactose; also able to transport glucose	galactose transport|galactose metabolic process	galactose transmembrane transporter activity|glucose transmembrane transporter activity	integral to membrane|plasma membrane
YOR178C	YOR178C	GAC1	hom	Verified	0.602288980190583	0.273490897432838	no	1370	0.276674278219883	929	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY			Regulatory subunit for Glc7p type-1 protein phosphatase (PP1), tethers Glc7p to Gsy2p glycogen synthase, binds Hsf1p heat shock transcription factor, required for induction of some HSF-regulated genes under heat shock	meiosis|glycogen metabolic process|negative regulation of transcription from RNA polymerase II promoter|response to heat|mitotic cell cycle spindle assembly checkpoint	protein phosphatase type 1 regulator activity|structural molecule activity|heat shock protein binding	protein phosphatase type 1 complex
YBR093C	YBR093C	PHO5	hom	Verified	0.60156757104133	0.273731010296845	no	1371	0.264390477703197	875	NA	FT	RESPONSE TO NUTRIENT LEVELS			Repressible acid phosphatase (1 of 3) that also mediates extracellular nucleotide-derived phosphate hydrolysis; secretory pathway derived cell surface glycoprotein; induced by phosphate starvation and coordinately regulated by PHO4 and PHO2	cellular response to phosphate starvation|phosphate-containing compound metabolic process|regulation of cell size	nucleoside-triphosphate diphosphatase activity|nucleoside-triphosphatase activity|acid phosphatase activity	fungal-type cell wall|cell wall-bounded periplasmic space
YDR033W	YDR033W	MRH1	hom	Verified	0.601382551636102	0.27379260870656	no	1372	0.274074021854598	936	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION|PLASMA MEMBRANE		Protein that localizes primarily to the plasma membrane; also found at the nuclear envelope; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; MRH1 has a paralog, YRO2, that arose from the whole genome duplication	biological_process	molecular_function	mitochondrion|integral to membrane|plasma membrane
YBR172C	YBR172C	SMY2	hom	Verified	0.601131668740559	0.273876145960513	no	1373	0.247450343062196	817	NA	FT	VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein of unknown function involved in COPII vesicle formation; interacts with the Sec23p/Sec24p subcomplex; overexpression suppresses the temperature sensitivity of a myo2 mutant; similar to S. pombe Mpd2; SMY2 has a paralog, SYH1, that arose from the whole genome duplication	ER to Golgi vesicle-mediated transport	molecular_function	endoplasmic reticulum membrane|cytoplasmic mRNA processing body|cytoplasm|extrinsic to membrane
YOL070C	YOL070C	NBA1	hom	Verified	0.600868936904979	0.273963642098787	no	1374	0.282343682663602	952	NA	FT		SITE OF POLARIZED GROWTH		Protein of unknown function, localizes to the bud neck and cytoplasm; interacts with Nap1p; may interact with ribosomes, based on co-purification experiments; potential Cdc28p substrate	biological_process	molecular_function	ribosome|cellular bud neck|cytoplasm
YOR292C_p	YOR292C	YOR292C	hom	Uncharacterized	0.600217082041644	0.274180785384239	no	1375	0.250391366364945	858	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YOR292C is not an essential gene	biological_process	molecular_function	integral to membrane|fungal-type vacuole
YLR283W_p	YLR283W	YLR283W	hom	Uncharacterized	0.600025261369788	0.274244700103951	no	1376	0.256832420913748	882	NA	FT		MITOCHONDRION		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR283W is not an essential gene	biological_process	molecular_function	mitochondrion
YDR512C	YDR512C	EMI1	hom	Verified	0.599840409683995	0.274306299715681	no	1377	0.266731918085687	921	NA	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|MITOCHONDRION ORGANIZATION			Non-essential protein required for transcriptional induction of the early meiotic-specific transcription factor IME1, also required for sporulation; contains twin cysteine-x9-cysteine motifs	ascospore formation|mitochondrial respiratory chain complex assembly|positive regulation of transcription from RNA polymerase II promoter	molecular_function	cellular_component
YPL271W	YPL271W	ATP15	hom	Verified	0.599517607370685	0.274413886101098	no	1378	0.30674258223797	1013	NA	FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS	MITOCHONDRION		Epsilon subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated	ATP synthesis coupled proton transport	hydrogen ion transporting ATP synthase activity, rotational mechanism|ATPase activity|proton-transporting ATPase activity, rotational mechanism	proton-transporting ATP synthase complex, catalytic core F(1)|mitochondrion|integral to membrane|mitochondrial proton-transporting ATP synthase, central stalk
YKR076W	YKR076W	ECM4	hom	Verified	0.599188850643558	0.274523478428146	no	1379	0.28031475459943	965	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|CELL WALL ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS			Omega class glutathione transferase; not essential; similar to Ygr154cp; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	fungal-type cell wall organization|glutathione metabolic process	glutathione transferase activity	cytoplasm
YBR289W	YBR289W	SNF5	hom	Verified	0.599052514528344	0.27456893293345	no	1380	0.300445565180065	977	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS	NUCLEUS|CHROMOSOME	RSC COMPLEX	Subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; functions interdependently in transcriptional activation with Snf2p and Snf6p; relocates to the cytosol under hypoxic conditions	sucrose catabolic process|double-strand break repair via homologous recombination|chromatin remodeling|carbon catabolite activation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II activating transcription factor binding	SWI/SNF complex|nucleus
YJR039W_p	YJR039W	YJR039W	hom	Uncharacterized	0.599028475031283	0.274576948094649	no	1381	0.237186884618314	844	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YOR358W	YOR358W	HAP5	hom	Verified	0.598673528592536	0.274695306470292	no	1382	0.265637658129897	909	NA	FT	TRANSCRIPTION FROM RNA POL II|OXIDATION-REDUCTION PROCESS|RESPONSE TO NUTRIENT LEVELS|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS		Subunit of the heme-activated, glucose-repressed Hap2/3/4/5 CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; required for assembly and DNA binding activity of the complex	carbon catabolite activation of transcription from RNA polymerase II promoter|regulation of cellular respiration	RNA polymerase II core promoter proximal region sequence-specific DNA binding|DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	CCAAT-binding factor complex
YER089C	YER089C	PTC2	hom	Verified	0.598348156266838	0.274803825331496	no	1383	0.241200677454188	807	NA	FT	CELL CYCLE|SIGNALING|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION	NUCLEUS		Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p to limit maximal osmostress induced kinase activity; dephosphorylates Ire1p to downregulate the unfolded protein response; dephosphorylates Cdc28p; inactivates the DNA damage checkpoint; PTC2 has a paralog, PTC3, that arose from the whole genome duplication	endoplasmic reticulum unfolded protein response|inactivation of MAPK activity involved in osmosensory signaling pathway|regulation of cyclin-dependent protein kinase activity|protein dephosphorylation|DNA damage checkpoint	protein serine/threonine phosphatase activity	nucleus|cytoplasm
YOL009C	YOL009C	MDM12	hom	Verified	0.5976554667738	0.275034922948906	no	1384	0.274501714610032	937	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION		Mitochondrial outer membrane protein, required for transmission of mitochondria to daughter cells; component of the ERMES complex that links the ER to mitochondria; may influence import and assembly of outer membrane beta-barrel proteins	mitochondrion inheritance|mitochondrion organization|protein import into mitochondrial outer membrane|phospholipid transport	molecular_function	mitochondrial outer membrane|mitochondrion|ERMES complex
YMR210W	YMR210W	YMR210W	hom	Verified	0.597331318435665	0.275143099381751	no	1385	0.241440620260635	792	NA	FT	KETONE METABOLISM|LIPID METABOLISM			Putative acyltransferase with similarity to Eeb1p and Eht1p, has a minor role in medium-chain fatty acid ethyl ester biosynthesis; may be involved in lipid metabolism and detoxification	medium-chain fatty acid biosynthetic process	transferase activity, transferring acyl groups	cellular_component
YHL046C	YHL046C	PAU13	hom	Verified	0.597168589129749	0.275197414131955	no	1386	0.255932460996827	854	NA					Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions; expression is induced after ethanol shock	biological_process	molecular_function	cellular_component
YGR071C	YGR071C	ENV11	hom	Verified	0.596529539565368	0.275410763078075	no	1387	0.261062525372657	898	NA	FT	VACUOLAR PROTEIN PROCESSING	NUCLEUS		Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and fragmented vacuoles; deletion mutant has increased glycogen accumulation and displays elongated buds; green fluorescent protein (GFP)-fusion protein localizes to the nucleus	vacuole organization|vacuolar protein processing	molecular_function	nucleus
YJL135W_d	YJL135W	YJL135W	hom	Dubious	0.595218881836863	0.275848585218653	no	1388	0.258606798863347	857	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL134W/LCB3	Unknown	Unknown	Unknown
YPR171W	YPR171W	BSP1	hom	Verified	0.594606453477939	0.276053282638122	no	1389	0.279258762474257	956	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON		Adapter that links synaptojanins Inp52p and Inp53p to the cortical actin cytoskeleton	actin cortical patch localization	protein binding, bridging	mating projection tip|membrane|cellular bud neck|actin cortical patch|cellular bud tip
YGL243W	YGL243W	TAD1	hom	Verified	0.594378230625333	0.276129582678563	no	1390	0.259688299261578	869	NA	FT	RNA PROCESSING	NUCLEUS		tRNA-specific adenosine deaminase, deaminates adenosine-37 to inosine in tRNA-Ala	tRNA modification	tRNA-specific adenosine-37 deaminase activity	nucleus
YCR017C	YCR017C	CWH43	hom	Verified	0.59400534592047	0.276254268705383	no	1391	0.326901703462008	1107	NA	FT	LIPID METABOLISM|CELL WALL ORG/BIOGENESIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Putative sensor/transporter protein involved in cell wall biogenesis; contains 14-16 transmembrane segments and several putative glycosylation and phosphorylation sites; null mutation is synthetically lethal with pkc1 deletion	fungal-type cell wall organization|GPI anchor biosynthetic process	molecular_function	integral to membrane|integral to plasma membrane|cellular bud neck|cellular bud tip
YGR203W	YGR203W	YCH1	hom	Verified	0.593574070612407	0.276398513959572	no	1392	0.277192011312628	934	NA	FT		NUCLEUS		Phosphatase with sequence similarity to Cdc25p, Arr2p and Mih1p; member of the single-domain rhodanese homology superfamily; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus	dephosphorylation	phosphatase activity|protein tyrosine phosphatase activity|thiosulfate sulfurtransferase activity	nucleus|cytoplasm
YNL047C	YNL047C	SLM2	hom	Verified	0.593435228289068	0.276444959316724	no	1393	0.248428727649494	835	NA	FT	VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|SIGNALING|CYTOSKELETON ORGANIZATION	PLASMA MEMBRANE		Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm1p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; phosphorylated by the TORC2 complex; SLM2 has a paralog, SLM1, that arose from the whole genome duplication	eisosome assembly|TOR signaling cascade|regulation of cell growth|actin filament bundle assembly|endosomal transport|establishment or maintenance of actin cytoskeleton polarity|actin cytoskeleton organization	phosphatidylinositol binding	plasma membrane
YLL039C	YLL039C	UBI4	hom	Verified	0.593264277299085	0.276502150880929	no	1394	0.244315624081496	814	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		Ubiquitin; becomes conjugated to proteins, marking them for selective degradation via the ubiquitin-26S proteasome system; essential for the cellular stress response; encoded as a polyubiquitin precursor comprised of 5 head-to-tail repeats; protein abundance increases in response to DNA replication stress	protein deubiquitination|ascospore formation|protein monoubiquitination|protein polyubiquitination|protein ubiquitination|response to stress	ATP-dependent protein binding|protein tag	cytoplasm
YOL049W	YOL049W	GSH2	hom	Verified	0.593015362636616	0.276585435522629	no	1395	0.270989716464642	946	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Glutathione synthetase, catalyzes the ATP-dependent synthesis of glutathione (GSH) from gamma-glutamylcysteine and glycine; induced by oxidative stress and heat shock	glutathione biosynthetic process	glutathione synthase activity	intracellular
YJL118W	YJL118W	YJL118W	hom	Verified	0.592832707477719	0.276646558142466	no	1396	0.258376958777764	892	NA					Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; YJL18W is a non-essential gene; deletion enhances the toxicity of heterologously expressed human alpha-synuclein	biological_process	molecular_function	ribosome
YAL042W	YAL042W	ERV46	hom	Verified	0.59075593928576	0.277341980451507	no	1397	0.290589818068989	973	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Protein localized to COPII-coated vesicles, forms a complex with Erv41p; involved in the membrane fusion stage of transport	ER to Golgi vesicle-mediated transport	molecular_function	integral to endoplasmic reticulum membrane|integral to Golgi membrane|ER to Golgi transport vesicle
YJR044C	YJR044C	VPS55	hom	Verified	0.590707436871774	0.277358232079252	no	1398	0.276048452435773	942	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT			Late endosomal protein involved in late endosome to vacuole trafficking; functional homolog of human obesity receptor gene-related protein (OB-RGRP)	late endosome to vacuole transport via multivesicular body sorting pathway	molecular_function	Vps55/Vps68 complex|late endosome|integral to membrane
YOR073W	YOR073W	SGO1	hom	Verified	0.590420884735029	0.277454256154928	no	1399	0.289952181597615	992	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME|CYTOSKELETON	KINETOCHORE	Component of the spindle checkpoint, involved in sensing lack of tension on mitotic chromosomes; protects centromeric Rec8p at meiosis I; required for accurate chromosomal segregation at meiosis II and for mitotic chromosome stability	positive regulation of maintenance of meiotic sister chromatid cohesion|meiotic sister chromatid segregation|meiotic sister chromatid separation|sister chromatid biorientation|maintenance of meiotic sister chromatid cohesion|mitotic cell cycle spindle assembly checkpoint|mitotic sister chromatid segregation	molecular_function	condensed nuclear chromosome kinetochore|nucleus|spindle pole body|condensed nuclear chromosome, centromeric region
YCL056C	YCL056C	PEX34	hom	Verified	0.589941573335429	0.277614910480195	no	1400	0.271507010839005	919	NA	FT	PEROXISOME ORGANIZATION			Peroxisomal integral membrane protein that regulates peroxisome populations; interacts with Pex11p, Pex25p, and Pex27p to control both constitutive peroxisome division and peroxisome morphology and abundance during peroxisome proliferation	peroxisome organization	molecular_function	integral to peroxisomal membrane|cytoplasm
YLR368W	YLR368W	MDM30	hom	Verified	0.589454761667908	0.277778125231215	no	1401	0.267491419581377	932	NA	FT	MEMBRANE ORGANIZATION|PROTEOLYSIS|MITOCHONDRION ORGANIZATION|RNA LOCALIZATION	MITOCHONDRION	UBIQUITIN LIGASE COMPLEX	F-box component of an SCF ubiquitin protein ligase complex; associates with and is required for Fzo1p ubiquitination and for mitochondria fusion; stimulates nuclear export of specific mRNAs; promotes ubiquitin-mediated degradation of Gal4p in some strains	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|chronological cell aging|proteolysis involved in cellular protein catabolic process|mitochondrion organization|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of mRNA export from nucleus|mitochondrial fusion	ubiquitin-protein ligase activity	mitochondrion|SCF ubiquitin ligase complex
YLL056C_p	YLL056C	YLL056C	hom	Uncharacterized	0.588514889872008	0.278093371254058	no	1402	0.237176744035757	805	NA					Putative protein of unknown function, transcription is activated by paralogous transcription factors Yrm1p and Yrr1p and genes involved in pleiotropic drug resistance (PDR); expression is induced in cells treated with the mycotoxin patulin	biological_process	molecular_function	cellular_component
YNR015W	YNR015W	SMM1	hom	Verified	0.587807133665812	0.278330877627373	no	1403	0.2500665071725	854	NA	FT	RNA PROCESSING|OXIDATION-REDUCTION PROCESS	NUCLEUS		Dihydrouridine synthase, member of a family of dihydrouridine synthases including Dus1p, Smm1p, Dus3p, and Dus4p; modifies uridine residues at position 20 of cytoplasmic tRNAs	tRNA processing|tRNA modification	tRNA dihydrouridine synthase activity	nucleus|cytoplasm
YHR021C	YHR021C	RPS27B	hom	Verified	0.587289085104582	0.278504785215336	no	1404	0.292182615939341	976	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S27, no bacterial homolog; RPS27B has a paralog, RPS27A, that arose from the whole genome duplication	cytoplasmic translation|ribosomal small subunit assembly|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome	cytosolic small ribosomal subunit
YER041W	YER041W	YEN1	hom	Verified	0.5871648650935	0.278546493424946	no	1405	0.273291519358158	984	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		Holliday junction resolvase; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1 and has similarity to S. cerevisiae endonuclease Rth1p	DNA repair|response to DNA damage stimulus	single-stranded DNA specific endodeoxyribonuclease activity|crossover junction endodeoxyribonuclease activity	nucleus|cytoplasm
YPL137C	YPL137C	GIP3	hom	Verified	0.586955480011308	0.278616803612074	no	1406	0.282347908848088	965	NA	FT	CHROMOSOME SEGREGATION	ENDOPLASMIC RETICULUM|MITOCHONDRION		Cytoplasmic protein that regulates protein phosphatase 1 Glc7p; overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation; may interact with ribosomes, based on co-purification experiments; GIP3 has a paralog, HER1, that arose from the whole genome duplication	chromosome segregation|regulation of phosphoprotein phosphatase activity	protein phosphatase type 1 regulator activity|protein phosphatase 1 binding	mitochondrion|ribosome|endoplasmic reticulum|cytoplasm
YKR054C	YKR054C	DYN1	hom	Verified	0.586809000683415	0.278665995581944	no	1407	0.245378282700667	816	NA	FT	CELL CYCLE|NUCLEOTIDE METABOLISM|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION	CYTOSKELETON		Cytoplasmic heavy chain dynein, microtubule motor protein, required for anaphase spindle elongation; involved in spindle assembly, chromosome movement, and spindle orientation during cell division, targeted to microtubule tips by Pac1p	nuclear migration along microtubule|establishment of mitotic spindle orientation|mitotic spindle elongation|mitotic sister chromatid segregation	microtubule motor activity	cytoplasmic dynein complex|cell cortex|cytoplasmic microtubule|spindle pole body|astral microtubule
YHR193C	YHR193C	EGD2	hom	Verified	0.586119786778504	0.278897510170982	no	1408	0.281614596591427	959	NA	FT	PROTEIN LOCALIZATION	NUCLEUS		Alpha subunit of the heteromeric nascent polypeptide-associated complex (NAC) involved in protein sorting and translocation, associated with cytoplasmic ribosomes	'de novo' cotranslational protein folding	unfolded protein binding|phosphatidic acid binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4-phosphate binding	nascent polypeptide-associated complex
YIL059C_d	YIL059C	YIL059C	hom	Dubious	0.585866676153982	0.278982556323132	no	1409	0.251639012632355	858	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YIL060W	Unknown	Unknown	Unknown
YMR164C	YMR164C	MSS11	hom	Verified	0.58569285594396	0.279040967893217	no	1410	0.275802329926549	939	NA	FT	TRANSCRIPTION FROM RNA POL II|CARBOHYDRATE METABOLISM	NUCLEUS		Transcription factor involved in regulation of invasive growth and starch degradation; controls the activation of FLO11 and STA2 in response to nutritional signals	biofilm formation|Unknown|positive regulation of starch catabolic process by positive regulation of transcription from RNA polymerase II promoter|positive regulation of invasive growth in response to glucose limitation by positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YPL119C-A_p	YPL119C-A	YPL119C-A	hom	Uncharacterized	0.585655665359339	0.279053466409309	no	1411	0.277340040396535	949	NA					Putative protein of unknown function; identified by expression profiling and mass spectrometry	biological_process	molecular_function	cellular_component
YLR044C	YLR044C	PDC1	hom	Verified	0.585524551097226	0.279097531714911	no	1412	0.292008314869282	1000	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS		Major of three pyruvate decarboxylase isozymes, key enzyme in alcoholic fermentation, decarboxylates pyruvate to acetaldehyde; subject to glucose-, ethanol-, and autoregulation; involved in amino acid catabolism	L-phenylalanine catabolic process|pyruvate metabolic process|glucose catabolic process to ethanol|tryptophan catabolic process|aromatic amino acid family catabolic process to alcohol via Ehrlich pathway	pyruvate decarboxylase activity	cytosol|nucleus|cytoplasm
YDR254W	YDR254W	CHL4	hom	Verified	0.584525261409512	0.279433487340071	no	1413	0.276925296408028	905	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME	KINETOCHORE	Outer kinetochore protein required for chromosome stability; involved in new kinetochore assembly and sister chromatid cohesion; peripheral component of the Ctf19 kinetochore complex that interacts with Ctf19p, Ctf3p, Iml3p and Mif2p; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-N and fission yeast mis15	kinetochore assembly|chromosome segregation|establishment of meiotic sister chromatid cohesion|protein localization to chromosome, centromeric region|maintenance of meiotic sister chromatid cohesion|establishment of mitotic sister chromatid cohesion	structural molecule activity	condensed nuclear chromosome outer kinetochore
YHR025W	YHR025W	THR1	hom	Verified	0.584497491080049	0.279442826374414	no	1414	0.300168699495395	1029	NA	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM			Homoserine kinase, conserved protein required for threonine biosynthesis; expression is regulated by the GCN4-mediated general amino acid control pathway	threonine biosynthetic process|methionine metabolic process|isoleucine metabolic process|homoserine metabolic process	homoserine kinase activity	cellular_component
YBR221C	YBR221C	PDB1	hom	Verified	0.584366369964974	0.279486923851164	no	1415	0.255851572585996	898	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		E1 beta subunit of the pyruvate dehydrogenase (PDH) complex, which is an evolutionarily-conserved multi-protein complex found in mitochondria	acetyl-CoA biosynthetic process from pyruvate	pyruvate dehydrogenase (acetyl-transferring) activity	mitochondrial nucleoid|mitochondrion|mitochondrial pyruvate dehydrogenase complex
YDR405W	YDR405W	MRP20	hom	Verified	0.583994950251073	0.279611854736699	no	1416	0.265390726544799	929	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YBR043C	YBR043C	QDR3	hom	Verified	0.583596020157682	0.279746069211032	no	1417	0.253536542081615	866	NA	FT		PLASMA MEMBRANE		Multidrug transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; has a role in polyamine homeostasis; expression is upregulated under polyamine stress; required for resistance to quinidine, barban, cisplatin, and bleomycin	drug transmembrane transport|polyamine homeostasis	drug transmembrane transporter activity|polyamine transmembrane transporter activity	integral to membrane|plasma membrane
YGR241C	YGR241C	YAP1802	hom	Verified	0.582922248995919	0.279972821090104	no	1418	0.291979873175371	1016	NA	FT	VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON		Protein of the AP180 family, involved in clathrin cage assembly; binds Pan1p and clathrin; YAP1802 has a paralog, YAP1801, that arose from the whole genome duplication	endocytosis	clathrin binding	actin cortical patch
YOR093C_p	YOR093C	YOR093C	hom	Uncharacterized	0.582884379277585	0.279985568462122	no	1419	0.236923089625369	779	NA	FT		NUCLEUS		Putative protein of unknown function; deletion causes sensitivity to unfolded protein response-inducing agents	biological_process	molecular_function	integral to membrane
YOL125W	YOL125W	TRM13	hom	Verified	0.581829076455897	0.280340908362191	no	1420	0.241484871183488	803	NA	FT	RNA PROCESSING	NUCLEUS		2'-O-methyltransferase responsible for modification of tRNA at position 4; C-terminal domain has similarity to Rossmann-fold (RFM) superfamily of RNA methyltransferases	tRNA methylation	tRNA methyltransferase activity	nucleus|cytoplasm
YNL318C	YNL318C	HXT14	hom	Verified	0.580681104951386	0.280727699342639	no	1421	0.257301234019321	877	NA	FT		MITOCHONDRION|PLASMA MEMBRANE		Protein with similarity to hexose transporter family members, expression is induced in low glucose and repressed in high glucose; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	hexose transport	galactose transmembrane transporter activity	mitochondrion|integral to membrane|plasma membrane
YKL074C	YKL074C	MUD2	hom	Verified	0.579240474045331	0.281213462209499	no	1422	0.247979378976977	849	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING	NUCLEUS		Protein involved in early pre-mRNA splicing; component of the pre-mRNA-U1 snRNP complex, the commitment complex; interacts with Msl5p/BBP splicing factor and Sub2p; similar to metazoan splicing factor U2AF65	mRNA branch site recognition	pre-mRNA branch point binding	commitment complex
YKR065C	YKR065C	PAM17	hom	Verified	0.578514583308184	0.281458377245678	no	1423	0.262582636652089	889	NA	FT	PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Constituent of the TIM23 complex; proposed alternatively to be a component of the import motor (PAM complex) or to interact with and modulate the core TIM23 (Translocase of the Inner mitochondrial Membrane) complex; protein abundance increases in response to DNA replication stress	protein import into mitochondrial matrix	molecular_function	mitochondrion|presequence translocase-associated import motor
YCL028W	YCL028W	RNQ1	hom	Verified	0.578224999115923	0.281556111463475	no	1424	0.262639639670769	926	NA	FT		NUCLEUS		[PIN(+)] prion, an infectious protein conformation that is generally an ordered protein aggregate	biological_process	molecular_function	cytosol
YNL194C	YNL194C	YNL194C	hom	Verified	0.578039523166897	0.28161871790853	no	1425	0.271697356516462	934	NA	FT		ENDOPLASMIC RETICULUM|PLASMA MEMBRANE		Integral membrane protein required for sporulation and plasma membrane sphingolipid content; has sequence similarity to SUR7 and FMP45; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; GFP-fusion protein is more abundant at MCCs (membrane compartment occupied by Can1) in the presence of glycerol and oleate	ascospore formation	molecular_function	cell cortex|integral to membrane|endoplasmic reticulum|plasma membrane|cytoplasm
YPL182C_d	YPL182C	YPL182C	hom	Dubious	0.577519004929739	0.281794451988904	no	1426	0.28292365879456	956	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CTI6/YPL181W	Unknown	Unknown	Unknown
YGR125W_p	YGR125W	YGR125W	hom	Uncharacterized	0.577268359843021	0.281879092048665	no	1427	0.27948250144079	990	NA					Putative protein of unknown function; deletion mutant has decreased rapamycin resistance but normal wormannin resistance; green fluorescent protein (GFP)-fusion protein localizes to the vacuole	biological_process	molecular_function	integral to membrane|fungal-type vacuole
YCL027W	YCL027W	FUS1	hom	Verified	0.577085539927249	0.28194083602686	no	1428	0.249710625062936	859	NA	FT	PROTEIN LOCALIZATION	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Membrane protein localized to the shmoo tip, required for cell fusion; expression regulated by mating pheromone; proposed to coordinate signaling, fusion, and polarization events required for fusion; potential Cdc28p substrate	regulation of termination of mating projection growth|cytogamy|cortical protein anchoring	molecular_function	integral to plasma membrane|mating projection tip
YMR037C	YMR037C	MSN2	hom	Verified	0.576167248940629	0.282251069999498	no	1429	0.275612353938491	949	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO NUTRIENT LEVELS|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		Transcriptional activator; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression; MSN2 has a paralog, MSN4, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress	positive regulation of transcription from RNA polymerase II promoter in response to heat stress|positive regulation of transcription from RNA polymerase II promoter in response to a hypotonic environment|positive regulation of transcription from RNA polymerase II promoter in response to alkalinity|positive regulation of transcription from RNA polymerase II promoter in response to amino acid starvation|positive regulation of transcription from RNA polymerase II promoter in response to zinc ion starvation|positive regulation of transcription from RNA polymerase II promoter in response to acidity|chromatin remodeling|positive regulation of transcription from RNA polymerase II promoter in response to hydrogen peroxide|regulation of replicative cell aging by regulation of transcription from RNA polymerase II promoter in response to caloric restriction|positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance|positive regulation of transcription from RNA polymerase II promoter in response to increased salt|positive regulation of transcription from RNA polymerase II promoter in response to freezing|positive regulation of transcription from RNA polymerase II promoter in response to ethanol|age-dependent response to oxidative stress involved in chronological cell aging|replicative cell aging|positive regulation of transcription from RNA polymerase II promoter in response to hydrostatic pressure|cellular response to methylmercury|positive regulation of transcription from RNA polymerase II promoter in response to nitrosative stress|positive regulation of transcription from RNA polymerase II promoter in response to cold|positive regulation of transcription from RNA polymerase II promoter in response to glucose starvation	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity|core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding	cytosol|nucleus
YOL099C_d	YOL099C	YOL099C	hom	Dubious	0.575568209489714	0.282453537036542	no	1430	0.247447874687345	868	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene PKH2/YOL100W; may interact with ribosomes	Unknown	Unknown	Unknown
YHR183W	YHR183W	GND1	hom	Verified	0.575271485743065	0.282553851413455	no	1431	0.274156982928564	924	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS	MITOCHONDRION		6-phosphogluconate dehydrogenase (decarboxylating); catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone and adaptation to oxidative stress; GND1 has a paralog, GND2, that arose from the whole genome duplication	cellular response to oxidative stress|pentose-phosphate shunt, oxidative branch	phosphogluconate dehydrogenase (decarboxylating) activity	mitochondrion|cytoplasm
YBR186W	YBR186W	PCH2	hom	Verified	0.575185037026798	0.282583080638102	no	1432	0.244780234703202	816	NA	FT	CELL CYCLE	NUCLEUS|CHROMOSOME		Nucleolar component of the pachytene checkpoint, which prevents chromosome segregation when recombination and chromosome synapsis are defective; also represses meiotic interhomolog recombination in the rDNA; required for meiotic double-stranded break formation	meiotic recombination checkpoint|meiotic DNA double-strand break formation|reciprocal meiotic recombination	ATPase activity	nucleolus
YPL090C	YPL090C	RPS6A	hom	Verified	0.574514924108711	0.282809702186121	no	1433	0.286446015993663	980	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S6, no bacterial homolog; RPS6A has a paralog, RPS6B, that arose from the whole genome duplication	cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome	small-subunit processome|cytosolic small ribosomal subunit|90S preribosome
YLR058C	YLR058C	SHM2	hom	Verified	0.57424710350357	0.282900299273361	no	1434	0.278815831191514	939	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	SITE OF POLARIZED GROWTH		Cytosolic serine hydroxymethyltransferase, converts serine to glycine plus 5,10 methylenetetrahydrofolate; major isoform involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis	one-carbon metabolic process	glycine hydroxymethyltransferase activity	plasma membrane|mating projection tip|cytoplasm
YPR150W_d	YPR150W	YPR150W	hom	Dubious	0.574151261656409	0.282932723585739	no	1435	0.254188266609756	859	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene SUE1/YPR151C	Unknown	Unknown	Unknown
YPR132W	YPR132W	RPS23B	hom	Verified	0.573748431968255	0.283069024645178	no	1436	0.26134787486815	888	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit, required for translational accuracy; homologous to mammalian ribosomal protein S23 and bacterial S12; RPS23B has a paralog, RPS23A, that arose from the whole genome duplication; deletion of both RPS23A and RPS23B is lethal	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|regulation of translational fidelity	structural constituent of ribosome	cytosolic small ribosomal subunit
YOL071W	YOL071W	EMI5	hom	Verified	0.573476179972726	0.28316116140725	no	1437	0.243874052850715	824	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Subunit of succinate dehydrogenase, which couples succinate oxidation to ubiquinone reduction; required for FAD cofactor attachment to Sdh1p; mutations in human ortholog PGL2 are associated with neuroendocrine tumors (paraganglioma)	protein-FAD linkage|cellular respiration|mitochondrial electron transport, succinate to ubiquinone|ascospore formation|tricarboxylic acid cycle|positive regulation of transcription from RNA polymerase II promoter	succinate dehydrogenase (ubiquinone) activity	mitochondrial respiratory chain complex II|mitochondrion|mitochondrial matrix
YMR254C_d	YMR254C	YMR254C	hom	Dubious	0.57269224878815	0.283426543310516	no	1438	0.279938728115702	949	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YLR149C	YLR149C	YLR149C	hom	Verified	0.572650941744158	0.283440530167906	no	1439	0.305281027505752	1033	NA					Protein of unknown function; overexpression causes a cell cycle delay or arrest; null mutation results in a decrease in plasma membrane electron transport; YLR149C is not an essential gene; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	cellular_component
YDL188C	YDL188C	PPH22	hom	Verified	0.571984033866163	0.283666395675579	no	1440	0.282517430692946	941	NA	FT	CELL CYCLE|TRANSLATION|CELL DIVISION|CYTOSKELETON ORGANIZATION	NUCLEUS|CHROMOSOME		Catalytic subunit of protein phosphatase 2A (PP2A); functionally redundant with Pph21p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis; protein abundance increases in response to DNA replication stress; PPH22 has a paralog, PPH21, that arose from the whole genome duplication	actin filament organization|budding cell bud growth|G1/S transition of mitotic cell cycle|protein dephosphorylation|mitotic cell cycle spindle assembly checkpoint|regulation of translation	protein serine/threonine phosphatase activity	condensed nuclear chromosome, centromeric region
YPL034W_p	YPL034W	YPL034W	hom	Uncharacterized	0.571880676340388	0.283701408074684	no	1441	0.296671792048622	1006	NA					Putative protein of unknown function; YPL034W is not essential gene	biological_process	molecular_function	cellular_component
YOR003W	YOR003W	YSP3	hom	Verified	0.571654925045615	0.283777888603574	no	1442	0.269936627647755	910	NA	FT	PROTEOLYSIS			Putative precursor to the subtilisin-like protease III	protein catabolic process	peptidase activity	cellular_component
YJL171C	YJL171C	YJL171C	hom	Verified	0.571482898580495	0.283836174741137	no	1443	0.248611115428844	822	NA	FT		MITOCHONDRION|PLASMA MEMBRANE		GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	mitochondrion|fungal-type cell wall|plasma membrane
YDL182W	YDL182W	LYS20	hom	Verified	0.57100373751944	0.283998554662217	no	1444	0.262263247151195	872	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS|MITOCHONDRION		Homocitrate synthase isozyme; catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; LYS20 has a paralog, LYS21, that arose from the whole genome duplication	lysine biosynthetic process via aminoadipic acid	homocitrate synthase activity	mitochondrion|nucleus
YAL067C	YAL067C	SEO1	hom	Verified	0.570753657306591	0.284083320443542	no	1445	0.272071124950728	889	NA					Putative permease, member of the allantoate transporter subfamily of the major facilitator superfamily; mutation confers resistance to ethionine sulfoxide	transport	transporter activity	integral to membrane|membrane
YGL157W	YGL157W	ARI1	hom	Verified	0.570129979317331	0.28429477153256	no	1446	0.275358580397595	939	NA	FT	OXIDATION-REDUCTION PROCESS	NUCLEUS		NADPH-dependent aldehyde reductase, utilizes aromatic and alophatic aldehyde substrates; member of the short-chain dehydrogenase/reductase superfamily	biological_process	oxidoreductase activity|carbonyl reductase (NADPH) activity	nucleus|cytoplasm
YJR059W	YJR059W	PTK2	hom	Verified	0.569490671214587	0.284511599888479	no	1447	0.319713842965315	1090	NA	FF|FT	CELL CYCLE|ION HOMEOSTASIS|PROTEIN PHOSPHORYLATION|ION HOMEOSTASIS	NUCLEUS|PLASMA MEMBRANE		Putative serine/threonine protein kinase involved in regulation of ion transport across plasma membrane; enhances spermine uptake	protein phosphorylation|cellular ion homeostasis|polyamine transport|G1/S transition of mitotic cell cycle|regulation of cell size	protein kinase activity	nucleus|plasma membrane|cytoplasm
YBR062C_p	YBR062C	YBR062C	hom	Uncharacterized	0.568495515212021	0.284849275052504	no	1448	0.270522030368317	908	NA					Protein of unknown function that interacts with Msb2p; may play a role in activation of the filamentous growth pathway.	biological_process	molecular_function	cellular_component
YDL211C_p	YDL211C	YDL211C	hom	Uncharacterized	0.568163340341427	0.284962030787675	no	1449	0.28387273278458	965	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole	biological_process	molecular_function	fungal-type vacuole
YKL066W_d	YKL066W	YKL066W	hom	Dubious	0.567858884773504	0.285065395983765	no	1450	0.235525590755333	819	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related <i>Saccharomyces</i> species; partially overlaps the verified gene YNK1	Unknown	Unknown	Unknown
YBR210W	YBR210W	ERV15	hom	Verified	0.567851181269125	0.28506801161939	no	1451	0.266463677357506	883	NA	FT	VESICLE-MEDIATED TRANSPORT|CELL CYCLE|SIGNALING|CELL DIVISION			Protein involved in export of proteins from the endoplasmic reticulum; ERV15 has a paralog, ERV14, that arose from the whole genome duplication	ER to Golgi vesicle-mediated transport|axial cellular bud site selection	molecular_function	integral to membrane|ER to Golgi transport vesicle
YJL193W_p	YJL193W	YJL193W	hom	Uncharacterized	0.567193232774044	0.285291452615602	no	1452	0.283740171537703	956	NA					Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect	biological_process	molecular_function	integral to membrane
YOR033C	YOR033C	EXO1	hom	Verified	0.566690436449576	0.285462259759109	no	1453	0.285424812049295	972	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS		5'-3' exonuclease and flap-endonuclease; involved in recombination, double-strand break repair and DNA mismatch repair; member of the Rad2p nuclease family, with conserved N and I nuclease domains; relative distribution to the nucleus increases upon DNA replication stress	mismatch repair|telomeric 3' overhang formation|DNA double-strand break processing|meiotic DNA double-strand break processing|telomere maintenance|gene conversion at mating-type locus, DNA double-strand break processing	5'-3' exonuclease activity|5'-flap endonuclease activity	nucleus
YJR047C	YJR047C	ANB1	hom	Verified	0.566668378719216	0.285469754202127	no	1454	0.289371005363428	981	NA	FT	KETONE METABOLISM|PROTEIN COMPLEX ORG/BIOGENESIS|AMINO ACID METABOLISM|TRANSLATION		RIBOSOME	Translation elongation factor eIF-5A; previously thought to function in translation initiation; undergoes an essential hypusination modification; expressed under anaerobic conditions; ANB1 has a paralog, HYP2, that arose from the whole genome duplication	translational frameshifting|positive regulation of translational termination|positive regulation of translational elongation	ribosome binding|RNA binding|translation elongation factor activity	cytosolic ribosome
YKR041W	YKR041W	YKR041W	hom	Verified	0.564770476767447	0.2861149452353	no	1455	0.269507362599539	876	NA	FT		NUCLEUS|CYTOSKELETON		Protein of unknown function; localizes to the mitotic spindle; overexpression of YKR041W affects endocytic protein trafficking	biological_process	molecular_function	nucleus|mitotic spindle|cytoplasm
YNL105W_d	YNL105W	RRT16	hom	Dubious	0.563578536277957	0.286520498780014	no	1456	0.257465083041305	875	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene INP52; identified in a screen for mutants with decreased levels of rDNA transcription	Unknown	Unknown	Unknown
YJL024C	YJL024C	APS3	hom	Verified	0.563558630448373	0.286527273982987	no	1457	0.301889909028208	1041	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Small subunit of the clathrin-associated adaptor complex AP-3; involved in vacuolar protein sorting; related to the sigma subunit of the mammalian clathrin AP-3 complex; suppressor of loss of casein kinase 1 function; protein abundance increases in response to DNA replication stress	Golgi to vacuole transport|vesicle-mediated transport	molecular_function	AP-3 adaptor complex
YPL047W	YPL047W	SGF11	hom	Verified	0.562378707954659	0.286929011365548	no	1458	0.280264573464121	978	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION	NUCLEUS	HISTONE ACETYLTRANSFERASE	Integral subunit of SAGA histone acetyltransferase complex, regulates transcription of a subset of SAGA-regulated genes, required for the Ubp8p association with SAGA and for H2B deubiquitylation	histone deubiquitination|regulation of transcription from RNA polymerase II promoter	enzyme activator activity	DUBm complex|nucleus|SAGA complex
YBR169C	YBR169C	SSE2	hom	Verified	0.561829877413112	0.287115966855459	no	1459	0.239689992886267	776	NA					Member of the heat shock protein 70 (HSP70) family; may be involved in protein folding; localized to the cytoplasm; SSE2 has a paralog, SSE1, that arose from the whole genome duplication	protein folding|protein refolding	adenyl-nucleotide exchange factor activity	cytoplasm
YLR171W_d	YLR171W	YLR171W	hom	Dubious	0.560858202526852	0.28744710284767	no	1460	0.298996584513047	1043	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YGR109C	YGR109C	CLB6	hom	Verified	0.560563460377193	0.287547583385089	no	1461	0.280004411706176	954	NA	FT	CELL CYCLE|CELL DIVISION|PROTEIN PHOSPHORYLATION	NUCLEUS		B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1	regulation of cyclin-dependent protein kinase activity|G1/S transition of mitotic cell cycle|regulation of S phase of mitotic cell cycle|premeiotic DNA replication	cyclin-dependent protein kinase regulator activity	cellular_component
YOL042W	YOL042W	NGL1	hom	Verified	0.560560807626284	0.287548487809719	no	1462	0.279472355170059	952	NA	FT		MITOCHONDRION		Putative endonuclease, has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	endonuclease activity	mitochondrion
YAL018C_p	YAL018C	YAL018C	hom	Uncharacterized	0.560545457185804	0.287553721390623	no	1463	0.295404791451128	965	NA					Putative protein of unknown function	biological_process	molecular_function	integral to membrane
YGL085W_p	YGL085W	LCL3	hom	Uncharacterized	0.560056303342045	0.287720517134062	no	1464	0.274699649215634	983	NA	FT		MITOCHONDRION		Putative protein of unknown function; mutant has long chronological lifespan; has homology to Staphylococcus aureus nuclease; GFP-fusion protein localizes to mitochondria; is induced in response to the DNA-damaging agent MMS	biological_process	molecular_function	mitochondrion
YNL218W	YNL218W	MGS1	hom	Verified	0.559971162125706	0.287749553964021	no	1465	0.24997894840224	838	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		Protein with DNA-dependent ATPase and ssDNA annealing activities; involved in maintenance of genome; interacts functionally with DNA polymerase delta; homolog of human Werner helicase interacting protein (WHIP); forms nuclear foci upon DNA replication stress	regulation of DNA repair|DNA replication, Okazaki fragment processing|DNA strand renaturation	ubiquitin binding|single-stranded DNA-dependent ATPase activity|enzyme activator activity	nucleus|cytoplasm
YGL259W_p	YGL259W	YPS5	hom	Uncharacterized	0.558978536197996	0.288088184371425	no	1466	0.276975199025322	948	NA	FT	PROTEOLYSIS			Protein with similarity to GPI-anchored aspartic proteases such as Yap1p and Yap3p	biological_process	aspartic-type endopeptidase activity	cellular_component
YHR022C_p	YHR022C	YHR022C	hom	Uncharacterized	0.557887890614821	0.288460470485985	no	1467	0.273326033202276	945	NA	FT	SIGNALING			Putative protein of unknown function; YHR022C is not an essential gene	biological_process	molecular_function	cellular_component
YEL005C	YEL005C	VAB2	hom	Verified	0.556674212761073	0.288875019375692	no	1468	0.287547940021916	960	NA					Protein with a potential role in vacuolar function, as suggested by its ability to bind Vac8p; likely member of BLOC complex involved in endosomal cargo sorting; Vab2p-GFP-fusion localizes to cytoplasm in punctate patter	biological_process	molecular_function	cytoplasm
YML002W_p	YML002W	YML002W	hom	Uncharacterized	0.555686550053293	0.289212576374351	no	1469	0.260376952058434	888	NA					Putative protein of unknown function; expression induced by heat and by calcium shortage	biological_process	molecular_function	cellular_component
YFL030W	YFL030W	AGX1	hom	Verified	0.555001433497146	0.289446839969748	no	1470	0.282194877207196	949	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		Alanine:glyoxylate aminotransferase (AGT), catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast; has similarity to mammalian and plant alanine:glyoxylate aminotransferases	glycine biosynthetic process, by transamination of glyoxylate	alanine-glyoxylate transaminase activity	mitochondrion
YDL059C	YDL059C	RAD59	hom	Verified	0.554827497550846	0.289506328500924	no	1471	0.305550549345571	1043	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		Protein involved DNA double-strand break repair; repairs breaks in DNA during vegetative growth via recombination and single-strand annealing; anneals complementary single-stranded DNA; forms nuclear foci upon DNA replication stress; required for loading of Rad52p to DSBs; paralog of Rad52p	DNA strand renaturation|telomere maintenance via recombination|double-strand break repair via break-induced replication|double-strand break repair via single-strand annealing	protein binding	nucleus
YNL237W	YNL237W	YTP1	hom	Verified	0.554747012071671	0.289533857605763	no	1472	0.345929361505599	1193	NA	FF|FT		MITOCHONDRION		Probable type-III integral membrane protein of unknown function, has regions of similarity to mitochondrial electron transport proteins	biological_process	molecular_function	integral to membrane|membrane
YOR129C	YOR129C	AFI1	hom	Verified	0.553621472449771	0.289918963831249	no	1473	0.278477839101333	960	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|CELL DIVISION	NUCLEUS|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Arf3p polarization-specific docking factor, required for the polarized distribution of the ADP-ribosylation factor, Arf3p; participates in polarity development and maintenance of a normal haploid budding pattern; interacts with Cnm7p	asymmetric protein localization|actin cortical patch localization|cellular bud site selection	molecular_function	nucleus|plasma membrane|cellular bud neck|cytoplasm
YMR148W	YMR148W	OSW5	hom	Verified	0.553484018755148	0.289966010414279	no	1474	0.246534128784804	815	NA					Protein of unknown function that may play a role in spore wall assembly; predicted to contain an N-terminal transmembrane domain; osw5 null mutant spores exhibit increased spore wall permeability and sensitivity to beta-glucanase digestion	biological_process	molecular_function	integral to membrane
YDR312W	YDR312W	SSF2	hom	Verified	0.551769171765734	0.290553255609344	no	1475	0.254727360136893	856	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS	NUCLEUS		Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication	conjugation with cellular fusion|ribosomal large subunit assembly	rRNA binding	nucleolus
YDR076W	YDR076W	RAD55	hom	Verified	0.550544683612724	0.290972918876656	no	1476	0.317735014826433	1078	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS		Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad57p	DNA recombinase assembly|heteroduplex formation|meiotic DNA recombinase assembly|double-strand break repair via single-strand annealing	DNA-dependent ATPase activity|protein heterodimerization activity	nucleus|Rhp55-Rhp57 complex
YHR078W_p	YHR078W	YHR078W	hom	Uncharacterized	0.5497707583148	0.291238308771252	no	1477	0.279494916295342	922	NA					High osmolarity-regulated gene of unknown function	biological_process	molecular_function	integral to membrane
YHR124W	YHR124W	NDT80	hom	Verified	0.548310936256505	0.2917392096868	no	1478	0.28087464639618	1002	NA	FT	CELL CYCLE|CELL DIVISION	NUCLEUS|CHROMOSOME		Meiosis-specific transcription factor required for exit from pachytene and for full meiotic recombination; activates middle sporulation genes; competes with Sum1p for binding to promoters containing middle sporulation elements (MSE)	meiosis|transcription, DNA-dependent	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	nuclear chromosome
YHR092C	YHR092C	HXT4	hom	Verified	0.547789473283274	0.291918233747978	no	1479	0.249185588319545	848	NA	FT		PLASMA MEMBRANE		High-affinity glucose transporter; member of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose; HXT4 has a paralog, HXT7, that arose from the whole genome duplication	hexose transport	pentose transmembrane transporter activity|mannose transmembrane transporter activity|glucose transmembrane transporter activity|fructose transmembrane transporter activity	integral to membrane|plasma membrane
YBR227C	YBR227C	MCX1	hom	Verified	0.547765014512385	0.291926631973125	no	1480	0.299362034085284	1032	NA	FT		MITOCHONDRION		Mitochondrial matrix protein; putative ATP-binding chaperone with non-proteolytic function; similar to bacterial ClpX proteins	protein refolding	molecular_function	mitochondrion|mitochondrial matrix
YCL024W	YCL024W	KCC4	hom	Verified	0.547001095463816	0.292188989760148	no	1481	0.292058290929226	1015	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Protein kinase of the bud neck involved in the septin checkpoint; associates with septin proteins, negatively regulates Swe1p by phosphorylation, shows structural homology to bud neck kinases Gin4p and Hsl1p; KCC4 has a paralog, GIN4, that arose from the whole genome duplication	budding cell bud growth|protein phosphorylation|septin checkpoint|septin ring assembly	phosphatidic acid binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylserine binding|protein kinase activity	incipient cellular bud site|cellular bud neck septin collar|plasma membrane|cellular bud neck|septin ring
YGR141W	YGR141W	VPS62	hom	Verified	0.546077086647474	0.29250647475786	no	1482	0.273424644203554	936	NA	FT	PROTEIN LOCALIZATION|VACUOLAR TRANSPORT			Vacuolar protein sorting (VPS) protein required for cytoplasm to vacuole targeting of proteins	protein targeting to vacuole	molecular_function	cellular_component
YNL335W_p	YNL335W	DDI3	hom	Uncharacterized	0.545604542725464	0.292668900522112	no	1483	0.293208559624624	1012	NA					Protein of unknown function; expression is induced over 100-fold by DNA damage; induction decreased in rad6 and rad18 mutants	biological_process	molecular_function	cellular_component
YGR136W	YGR136W	LSB1	hom	Verified	0.545567795225398	0.292681533359059	no	1484	0.256973585362412	874	NA	FT		NUCLEUS		Protein containing an N-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein increases in abundance and forms nuclear foci in response to DNA replication stress	biological_process	molecular_function	nucleus|cytoplasm
YPR018W	YPR018W	RLF2	hom	Verified	0.544751305058099	0.292962286799934	no	1485	0.283726073757647	953	NA	FT	CHROMATIN ORGANIZATION	NUCLEUS|CHROMOSOME		Largest subunit (p90) of the Chromatin Assembly Complex (CAF-1); chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of the DNA damage checkpoint after DNA repair; and chromatin dynamics during transcription	DNA replication-dependent nucleosome assembly	histone binding	chromosome, centromeric region|nucleus|CAF-1 complex
YDR156W	YDR156W	RPA14	hom	Verified	0.543549266560322	0.293375839849542	no	1486	0.255083947091803	884	NA	FT		NUCLEUS		RNA polymerase I subunit A14	transcription of nuclear large rRNA transcript from RNA polymerase I promoter|regulation of cell size	molecular_function	DNA-directed RNA polymerase I complex
YPR038W_d	YPR038W	IRC16	hom	Dubious	0.542674633224369	0.293676921322732	no	1487	0.284630579531149	969	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene YPR037C; null mutant displays increased levels of spontaneous Rad52p foci	Unknown	Unknown	Unknown
YHR182W	YHR182W	YHR182W	hom	Verified	0.542290474082452	0.29380920844126	no	1488	0.314648065528261	1076	NA	FT	SIGNALING			Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and cytoplasm; relocalizes from bud neck to cytoplasm upon DNA replication stress	biological_process	molecular_function	cytoplasm
YGR228W_d	YGR228W	YGR228W	hom	Dubious	0.541897064716077	0.293944709485829	no	1489	0.311105922171237	1076	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SMI1/YGR229C	Unknown	Unknown	Unknown
YIL095W	YIL095W	PRK1	hom	Verified	0.541825630717413	0.293969316426256	no	1490	0.285136665321303	963	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Protein serine/threonine kinase; regulates the organization and function of the actin cytoskeleton and reduces endocytic ability of cell through the phosphorylation of the Pan1p-Sla1p-End3p protein complex; PRK1 has a paralog, ARK1, that arose from the whole genome duplication	regulation of endocytosis|actin filament organization|protein phosphorylation|actin cortical patch assembly|cytokinesis	protein serine/threonine kinase activity|protein kinase activity	mating projection tip|actin cortical patch
YGR079W_p	YGR079W	YGR079W	hom	Uncharacterized	0.541270492268887	0.294160577972942	no	1491	0.299121808384493	1002	NA					Putative protein of unknown function; YGR079W is not an essential gene	biological_process	molecular_function	cellular_component
YJR003C_p	YJR003C	YJR003C	hom	Uncharacterized	0.540541825968379	0.294411712206748	no	1492	0.295983596859982	1007	NA	FT		MITOCHONDRION		Putative protein of unknown function; detected in highly purified mitochondria in high-throughput studies; predicted to be involved in ribosome biogenesis	biological_process	molecular_function	mitochondrion
YLL010C	YLL010C	PSR1	hom	Verified	0.540151128400134	0.294546406549348	no	1493	0.308106387534542	1052	NA	FT		PLASMA MEMBRANE		Plasma membrane associated protein phosphatase involved in the general stress response; required along with binding partner Whi2p for full activation of STRE-mediated gene expression, possibly through dephosphorylation of Msn2p	response to stress	phosphoprotein phosphatase activity	plasma membrane
YJR090C	YJR090C	GRR1	hom	Verified	0.539208248139642	0.294871584851839	no	1494	0.330545152945543	1110	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CARBOHYDRATE METABOLISM|PROTEOLYSIS	NUCLEUS|SITE OF POLARIZED GROWTH|CYTOSKELETON	UBIQUITIN LIGASE COMPLEX	F-box protein component of the SCF ubiquitin-ligase complex; involved in carbon catabolite repression, glucose-dependent divalent cation transport, high-affinity glucose transport, morphogenesis, and sulfite detoxification	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|cellular response to methylmercury|cell cycle arrest in response to pheromone|G1/S transition of mitotic cell cycle|response to DNA damage stimulus|protein ubiquitination	ubiquitin-protein ligase activity|protein binding, bridging	cellular bud neck contractile ring|SCF ubiquitin ligase complex|nucleus|cytoplasm
YOR184W	YOR184W	SER1	hom	Verified	0.538271439237378	0.295194833050915	no	1495	0.302890486242009	1036	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			3-phosphoserine aminotransferase; catalyzes the formation of phosphoserine from 3-phosphohydroxypyruvate, required for serine and glycine biosynthesis; regulated by the general control of amino acid biosynthesis mediated by Gcn4p; protein abundance increases in response to DNA replication stress	serine family amino acid biosynthetic process|L-serine biosynthetic process|purine nucleobase biosynthetic process	O-phospho-L-serine:2-oxoglutarate aminotransferase activity	cytoplasm
YCR065W	YCR065W	HCM1	hom	Verified	0.537785081814922	0.295362716174774	no	1496	0.295193146413096	1045	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION|RESPONSE TO OXIDATIVE STRESS	NUCLEUS|CHROMOSOME		Forkhead transcription factor that drives S-phase specific expression of genes involved in chromosome segregation, spindle dynamics, and budding; suppressor of calmodulin mutants with specific SPB assembly defects; telomere maintenance role	positive regulation of transcription involved in S-phase of mitotic cell cycle|cellular response to oxidative stress|mitochondrion organization|spindle pole body organization|positive regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding	nuclear chromatin|nucleus|cytoplasm
YHL009C	YHL009C	YAP3	hom	Verified	0.536890300787015	0.295671695563835	no	1497	0.309521211521486	1042	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Basic leucine zipper (bZIP) transcription factor	regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	nucleus
YGR052W_p	YGR052W	FMP48	hom	Uncharacterized	0.536121668723151	0.295937232648076	no	1498	0.333855622149554	1105	NA	FT	PROTEIN PHOSPHORYLATION	MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; induced by treatment with 8-methoxypsoralen and UVA irradiation	protein phosphorylation	protein kinase activity	mitochondrion
YAR035C-A_p	YAR035C-A	YAR035C-A	hom	Uncharacterized	0.535703053584935	0.296081896444586	no	1499	0.278922056583835	967	NA					Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; predicted to have a role in cell budding based on computational guilt by association analysis	biological_process	molecular_function	cellular_component
YER019W	YER019W	ISC1	hom	Verified	0.535255918514499	0.296236451911465	no	1500	0.305779193933694	1013	NA	FT	LIPID METABOLISM	ENDOPLASMIC RETICULUM|MITOCHONDRION		Mitochondrial membrane localized inositol phosphosphingolipid phospholipase C, hydrolyzes complex sphingolipids to produce ceramide; activated by phosphatidylserine, cardiolipin, and phosphatidylglycerol; mediates Na+ and Li+ halotolerance	response to salt stress|ceramide biosynthetic process|sphingolipid catabolic process	inositol phosphosphingolipid phospholipase activity	mitochondrion|endoplasmic reticulum|integral to mitochondrial outer membrane
YEL011W	YEL011W	GLC3	hom	Verified	0.534878392539349	0.296366975296549	no	1501	0.271487173368111	917	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY			Glycogen branching enzyme, involved in glycogen accumulation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress	glycogen biosynthetic process	1,4-alpha-glucan branching enzyme activity	cytoplasm
YCR090C_p	YCR090C	YCR090C	hom	Uncharacterized	0.53468581856936	0.296433564726472	no	1502	0.248157627463534	844	NA	FT		NUCLEUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YCR090C is not an essential gene	biological_process	molecular_function	nucleus|cytoplasm
YNR056C	YNR056C	BIO5	hom	Verified	0.534167948388232	0.29661267112012	no	1503	0.288227322173806	984	NA	FT	KETONE METABOLISM|COFACTOR METABOLISM	PLASMA MEMBRANE		Putative transmembrane protein involved in the biotin biosynthesis pathway; responsible for uptake of 7-keto 8-aminopelargonic acid; BIO5 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis	biotin biosynthetic process|vitamin transport	transmembrane transporter activity	integral to membrane|plasma membrane
YKL147C_d	YKL147C	YKL147C	hom	Dubious	0.534024110215851	0.296662426621931	no	1504	0.25279464362865	846	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene AVT3	Unknown	Unknown	Unknown
YMR276W	YMR276W	DSK2	hom	Verified	0.533816769128079	0.296734155336657	no	1505	0.265647509287648	911	NA	FT	CELL CYCLE|PROTEOLYSIS|CYTOSKELETON ORGANIZATION	NUCLEUS		Nuclear-enriched ubiquitin-like polyubiquitin-binding protein; required for spindle pole body (SPB) duplication and for transit through the G2/M phase of the cell cycle; involved in proteolysis; interacts with the proteasome; protein abundance increases in response to DNA replication stress	ER-associated protein catabolic process|spindle pole body duplication associated with nuclear envelope	protein binding, bridging	nucleus
YJL115W	YJL115W	ASF1	hom	Verified	0.532494475292152	0.297191783607034	no	1506	0.267103100513688	901	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS		Nucleosome assembly factor, involved in chromatin assembly and disassembly, anti-silencing protein that causes derepression of silent loci when overexpressed; plays a role in regulating Ty1 transposition	DNA replication-independent nucleosome assembly|histone acetylation|nucleosome disassembly|histone exchange|positive regulation of histone acetylation|chromatin silencing at silent mating-type cassette|chromatin silencing at telomere|DNA replication-dependent nucleosome assembly|regulation of transcription from RNA polymerase II promoter in response to stress	histone binding	chromatin assembly complex
YHR030C	YHR030C	SLT2	hom	Verified	0.532124365633521	0.297319931388359	no	1507	0.364860106627725	1235	NA	FF|FT	PROTEIN LOCALIZATION|RNA PROCESSING|SIGNALING|CELL WALL ORG/BIOGENESIS|CELL DIVISION|PROTEIN PHOSPHORYLATION|PEROXISOME ORGANIZATION	NUCLEUS|SITE OF POLARIZED GROWTH		Serine/threonine MAP kinase; involved in regulating maintenance of cell wall integrity, progression through the cell cycle, and nuclear mRNA retention in heat shock; required for mitophagy and pexophagy; affects recruitment of mitochondria to the phagophore assembly site (PAS); regulated by the PKC1-mediated signaling pathway	protein phosphorylation|endoplasmic reticulum unfolded protein response|signal transduction|UFP-specific transcription factor mRNA processing involved in endoplasmic reticulum unfolded protein response|fungal-type cell wall organization|peroxisome degradation|regulation of transcription factor import into nucleus|barrier septum assembly|response to acid|regulation of cell size	MAP kinase activity|protein serine/threonine kinase activity|protein kinase activity	nucleus|cytoplasm|cellular bud tip
YIL117C	YIL117C	PRM5	hom	Verified	0.531943589850551	0.297382532866125	no	1508	0.280930624627417	979	NA					Pheromone-regulated protein, predicted to have 1 transmembrane segment; induced during cell integrity signaling	biological_process	molecular_function	integral to membrane
YIL032C_d	YIL032C	YIL032C	hom	Dubious	0.531094317233286	0.297676711001056	no	1509	0.309951171618808	1038	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YLR052W	YLR052W	IES3	hom	Verified	0.531093576236624	0.297676967731633	no	1510	0.292645223683582	981	NA	FT	CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS|CHROMOSOME		Subunit of the INO80 chromatin remodeling complex	nucleosome mobilization|telomere maintenance|chromatin silencing at telomere	molecular_function	nucleus|Ino80 complex
YJL189W	YJL189W	RPL39	hom	Verified	0.531063265208643	0.297687469576342	no	1511	0.291374109494443	992	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L39; required for ribosome biogenesis; loss of both Rpl31p and Rpl39p confers lethality; also exhibits genetic interactions with SIS1 and PAB1; homologous to mammalian ribosomal protein L39, no bacterial homolog	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YOR137C	YOR137C	SIA1	hom	Verified	0.530651918360775	0.297830005396984	no	1512	0.275597342575201	964	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Protein of unassigned function involved in activation of the Pma1p plasma membrane H+-ATPase by glucose	proton transport	molecular_function	cellular_component
YLR348C	YLR348C	DIC1	hom	Verified	0.529912560164028	0.298086278665929	no	1513	0.290102195452267	960	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Mitochondrial dicarboxylate carrier, integral membrane protein, catalyzes a dicarboxylate-phosphate exchange across the inner mitochondrial membrane, transports cytoplasmic dicarboxylates into the mitochondrial matrix	dicarboxylic acid transport	dicarboxylic acid transmembrane transporter activity	mitochondrial envelope|mitochondrion|integral to membrane
YMR167W	YMR167W	MLH1	hom	Verified	0.529699979870974	0.298159980957373	no	1514	0.275070907832483	949	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS|MITOCHONDRION|CHROMOSOME		Protein required for mismatch repair in mitosis and meiosis as well as crossing over during meiosis; forms a complex with Pms1p and Msh2p-Msh3p during mismatch repair; human homolog is associated with hereditary non-polyposis colon cancer	mismatch repair|meiotic mismatch repair|reciprocal meiotic recombination|meiotic heteroduplex formation	double-stranded DNA binding|DNA insertion or deletion binding|loop DNA binding|single-stranded DNA binding|dinucleotide insertion or deletion binding|ATPase activity|ATP binding	mitochondrion|nucleus|MutLalpha complex|MutLbeta complex|cytoplasm
YJL049W_p	YJL049W	YJL049W	hom	Uncharacterized	0.529208956304489	0.298330252175455	no	1515	0.25110384784887	848	NA	FT	PROTEIN LOCALIZATION			Putative protein of unknown function; YJL049W is a non-essential gene	biological_process	molecular_function	cellular_component
YKR052C	YKR052C	MRS4	hom	Verified	0.52791094915144	0.298780572432728	no	1516	0.271754025927504	910	NA	FT	RNA PROCESSING|ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Iron transporter of the mitochondrial carrier family; mediates Fe2+ transport across the inner mitochondrial membrane; active under low-iron conditions; may transport other cations; protein abundance increases in response to DNA replication stress; MRS4 has a paralog, MRS3, that arose from the whole genome duplication	mitochondrial iron ion transport|RNA splicing	iron ion transmembrane transporter activity	mitochondrion|integral to membrane|mitochondrial inner membrane
YDR501W	YDR501W	PLM2	hom	Verified	0.527586513388507	0.298893177831547	no	1517	0.276633009773651	937	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Putative transcription factor, contains Forkhead Associated domain; found associated with chromatin; target of SBF transcription factor; induced in response to DNA damaging agents and deletion of telomerase; PLM2 has a paralog, TOS4, that arose from the whole genome duplication	response to DNA damage stimulus	chromatin binding	nuclear chromatin
YKL162C_p	YKL162C	YKL162C	hom	Uncharacterized	0.527235264447527	0.299015111298831	no	1518	0.274883690595827	933	NA	FT		MITOCHONDRION		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion	biological_process	molecular_function	mitochondrion
YML081C-A	YML081C-A	ATP18	hom	Verified	0.526396849323163	0.299306252163099	no	1519	0.285660143978179	957	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS	MITOCHONDRION		Subunit of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; termed subunit I or subunit j; does not correspond to known ATP synthase subunits in other organisms	mitochondrial proton-transporting ATP synthase complex assembly|ATP synthesis coupled proton transport	hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism	mitochondrion|mitochondrial proton-transporting ATP synthase complex|mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
YGR163W	YGR163W	GTR2	hom	Verified	0.526380253812505	0.299312016275796	no	1520	0.334918533763086	1125	NA	FF|FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|MEMBRANE ORGANIZATION	NUCLEUS|CHROMOSOME		Putative GTP binding protein that negatively regulates Ran/Tc4 GTPase cycle; activates transcription; subunit of EGO and GSE complexes; required for sorting of Gap1p; localizes to cytoplasm and to chromatin; homolog of human RagC and RagD	microautophagy|positive regulation of transcription from RNA polymerase II promoter	GTP binding	nuclear chromatin|fungal-type vacuole membrane|integral to membrane|EGO complex|nucleus|late endosome membrane|cytoplasm
YJL208C	YJL208C	NUC1	hom	Verified	0.526150014783404	0.299391990308888	no	1521	0.301489744391305	1034	NA	FT		NUCLEUS|MITOCHONDRION		Major mitochondrial nuclease, has RNAse and DNA endo- and exonucleolytic activities; has roles in mitochondrial recombination, apoptosis and maintenance of polyploidy	DNA catabolic process|RNA catabolic process|apoptotic process|DNA recombination	ribonuclease activity|endodeoxyribonuclease activity|exodeoxyribonuclease activity	mitochondrion|mitochondrial inner membrane|nucleus
YCR060W	YCR060W	TAH1	hom	Verified	0.525561723870397	0.299596378449115	no	1522	0.293987712986248	957	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS	NUCLEUS		Component of the conserved R2TP complex (Rvb1-Rvb2-Tah1-Pih1); contains a single TPR domain with at least two TPR motifs; R2TP complex interacts with Hsp90 (Hsp82p and Hsc82p) to mediate assembly large protein complexes such as box C/D snoRNPs and RNA polymerase II	protein folding|box C/D snoRNP assembly	chaperone binding	R2TP complex|nucleus|cytoplasm
YML106W	YML106W	URA5	hom	Verified	0.524941207305447	0.299812031140757	no	1523	0.297178493931761	1022	NA	FT	NUCLEOTIDE METABOLISM	NUCLEUS		Major orotate phosphoribosyltransferase (OPRTase) isozyme; catalyzes the fifth enzymatic step in de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; URA5 has a paralog, URA10, that arose from the whole genome duplication	'de novo' pyrimidine nucleobase biosynthetic process|pyrimidine ribonucleoside biosynthetic process	orotate phosphoribosyltransferase activity	nucleus|cytoplasm
YLR456W_p	YLR456W	YLR456W	hom	Uncharacterized	0.523374750095918	0.300356745961692	no	1524	0.272666187420476	960	NA	FT	OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM	NUCLEUS		Putative pyridoxal 5'-phosphate synthase; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2; YLR456W has a paralog, YPR172W, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YLR041W_d	YLR041W	YLR041W	hom	Dubious	0.522447015399198	0.300679564172468	no	1525	0.282995937009437	966	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YLR040C	Unknown	Unknown	Unknown
YHR134W	YHR134W	WSS1	hom	Verified	0.521777520457563	0.300912621497321	no	1526	0.2454195136943	864	NA	FT	RESPONSE TO DNA DAMAGE	ENDOMEMBRANE SYSTEM|NUCLEUS		Sumoylated protein that localizes to a single spot on the nuclear periphery of mother cells but not daughters; interacts genetically with SMT3; UV-sensitive mutant phenotype and genetic interactions suggest a role in the DNA damage response	protein sumoylation|response to UV-B|response to UV-C|response to DNA damage stimulus	molecular_function	nuclear envelope
YMR052W	YMR052W	FAR3	hom	Verified	0.521635551979384	0.300962052492466	no	1527	0.316329585184279	1094	NA	FT	CELL CYCLE|SIGNALING	ENDOPLASMIC RETICULUM		Protein of unknown function; involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far7p, Far8p, Far9p, Far10p, and Far11p; localizes to the endoplasmic reticulum; protein abundance increases in response to DNA replication stress	re-entry into mitotic cell cycle after pheromone arrest	molecular_function	endoplasmic reticulum
YKL015W	YKL015W	PUT3	hom	Verified	0.52151202919113	0.301005063992222	no	1528	0.28460281420267	971	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Transcriptional activator of proline utilization genes, constitutively binds PUT1 and PUT2 promoter sequences as a dimer and undergoes a conformational change to form the active state; differentially phosphorylated in the presence of different nitrogen sources; has a Zn(2)-Cys(6) binuclear cluster domain	Unknown|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YBR139W	YBR139W	YBR139W	hom	Verified	0.521067195815253	0.30115998104132	no	1529	0.311045198505513	1038	NA	FT	PROTEOLYSIS			Putative serine type carboxypeptidase with a role in phytochelatin synthesis; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner	phytochelatin biosynthetic process	serine hydrolase activity|serine-type carboxypeptidase activity	fungal-type vacuole
YGR222W	YGR222W	PET54	hom	Verified	0.520768723864123	0.301263946598778	no	1530	0.307249088956173	1045	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial inner membrane protein; binds to the 5' UTR of the COX3 mRNA to activate its translation together with Pet122p and Pet494p; also binds to the COX1 Group I intron AI5 beta to facilitate exon ligation during splicing	Group I intron splicing|positive regulation of mitochondrial translation|mitochondrial respiratory chain complex IV biogenesis	translation regulator activity|RNA binding	mitochondrion|extrinsic to mitochondrial inner membrane|mitochondrial inner membrane|mitochondrial matrix
YOR303W	YOR303W	CPA1	hom	Verified	0.520511330279413	0.301353616468968	no	1531	0.280532394815222	941	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Small subunit of carbamoyl phosphate synthetase, which catalyzes a step in the synthesis of citrulline, an arginine precursor; translationally regulated by an attenuator peptide encoded by YOR302W within the CPA1 mRNA 5'-leader	arginine biosynthetic process	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity	carbamoyl-phosphate synthase complex
YMR144W_p	YMR144W	YMR144W	hom	Uncharacterized	0.520345952886845	0.301411236402168	no	1532	0.296897932193965	973	NA	FT		NUCLEUS		Putative protein of unknown function; localized to the nucleus; YMR144W is not an essential gene	biological_process	molecular_function	nucleus
YML080W	YML080W	DUS1	hom	Verified	0.519612465858284	0.301666853899089	no	1533	0.2553248117392	858	NA	FT	RNA PROCESSING|OXIDATION-REDUCTION PROCESS	NUCLEUS		Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus3p, and Dus4p; modifies pre-tRNA(Phe) at U17	tRNA modification	tRNA dihydrouridine synthase activity	nucleus
YDR345C	YDR345C	HXT3	hom	Verified	0.51933077907267	0.301765046596236	no	1534	0.329681422216119	1114	NA	FT		PLASMA MEMBRANE		Low affinity glucose transporter of the major facilitator superfamily; expression is induced in low or high glucose conditions; HXT3 has a paralog, HXT5, that arose from the whole genome duplication	hexose transport|transmembrane transport	mannose transmembrane transporter activity|fructose transmembrane transporter activity|glucose transmembrane transporter activity	integral to membrane|plasma membrane
YIL060W_p	YIL060W	YIL060W	hom	Uncharacterized	0.519057459048779	0.30186033647063	no	1535	0.312947738477919	1084	NA					Putative protein of unknown function; mutant accumulates less glycogen than does wild type; null mutation results in a decrease in plasma membrane electron transport; YIL060W is not an essential gene	biological_process	molecular_function	cellular_component
YDR340W_d	YDR340W	YDR340W	hom	Dubious	0.519052778824699	0.301861968294532	no	1536	0.282556815072341	934	NA					Putative protein of unknown function	Unknown	Unknown	Unknown
YNL031C	YNL031C	HHT2	hom	Verified	0.518458200280837	0.302069308438443	no	1537	0.287457164424066	963	NA	FT	CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Histone H3, core histone protein required for chromatin assembly, part of heterochromatin-mediated telomeric and HM silencing; one of two identical histone H3 proteins (see HHT1); regulated by acetylation, methylation, and phosphorylation	chromatin assembly or disassembly|global genome nucleotide-excision repair|rRNA transcription|sexual sporulation resulting in formation of a cellular spore|mitotic cell cycle spindle assembly checkpoint	DNA binding	nuclear nucleosome
YML120C	YML120C	NDI1	hom	Verified	0.517690816866907	0.302337003208801	no	1538	0.281308797819629	965	NA	FT	OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		NADH:ubiquinone oxidoreductase; transfers electrons from NADH to ubiquinone in the respiratory chain but does not pump protons, in contrast to the higher eukaryotic multisubunit respiratory complex I; phosphorylated; involved in Mn and H2O2 induced apoptosis; upon apoptotic stress, Ndip is activated in the mitochondria by N-terminal cleavage, and the truncated protein translocates to the cytoplasm to induce apoptosis; homolog of human AMID	mitochondrial electron transport, NADH to ubiquinone|NADH oxidation|chronological cell aging|positive regulation of apoptotic process	NADH dehydrogenase (ubiquinone) activity	mitochondrion|mitochondrial matrix
YER040W	YER040W	GLN3	hom	Verified	0.517608929271114	0.302365575239591	no	1539	0.291794154785361	1002	NA	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Transcriptional activator of genes regulated by nitrogen catabolite repression (NCR), localization and activity regulated by quality of nitrogen source	nitrogen catabolite activation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	cytosol|nucleus
YOL104C	YOL104C	NDJ1	hom	Verified	0.517526389262065	0.302394376134491	no	1540	0.267359119674855	910	NA	FT	CELL CYCLE	NUCLEUS|CHROMOSOME		Meiosis-specific telomere protein, required for bouquet formation, effective homolog pairing, ordered cross-over distribution, sister chromatid cohesion at meiotic telomeres, chromosomal segregation and telomere-led rapid prophase movement	meiotic telomere clustering|synapsis|attachment of telomeric heterochromatin to nuclear envelope|regulation of reciprocal meiotic recombination|reciprocal meiotic recombination	telomeric DNA binding	nuclear chromosome, telomeric region
YFR032C_p	YFR032C	RRT5	hom	Uncharacterized	0.516798690012083	0.302648347302579	no	1541	0.299309070083699	1047	NA					Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; expressed at high levels during sporulation	biological_process	molecular_function	cellular_component
YLR357W	YLR357W	RSC2	hom	Verified	0.516375649620322	0.302796034716575	no	1542	0.311487325011742	1041	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION	NUCLEUS	RSC COMPLEX	Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; involved in telomere maintenance	ATP-dependent chromatin remodeling|chromosome segregation|nucleosome disassembly|plasmid maintenance|sister chromatid cohesion|double-strand break repair via nonhomologous end joining|transcription elongation from RNA polymerase II promoter|double-strand break repair via homologous recombination	DNA translocase activity	RSC complex
YCR050C_p	YCR050C	YCR050C	hom	Uncharacterized	0.516183602951984	0.302863090680028	no	1543	0.264154818378589	908	NA					Non-essential protein of unknown function; deletion mutant is synthetically sick or lethal with alpha-synuclein	biological_process	molecular_function	cellular_component
YPR149W	YPR149W	NCE102	hom	Verified	0.515554608652819	0.303082759968438	no	1544	0.290526961849059	1001	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|PROTEIN PHOSPHORYLATION	ENDOPLASMIC RETICULUM|MITOCHONDRION|PLASMA MEMBRANE		Protein of unknown function; contains transmembrane domains; involved in secretion of proteins that lack classical secretory signal sequences; component of the detergent-insoluble glycolipid-enriched complexes (DIGs)	eisosome assembly|protein secretion|negative regulation of protein phosphorylation|plasma membrane organization|establishment of protein localization to plasma membrane	molecular_function	mitochondrion|integral to membrane|membrane raft|endoplasmic reticulum|cellular bud membrane|plasma membrane|mating projection membrane|cytoplasm
YCR009C	YCR009C	RVS161	hom	Verified	0.51403282762941	0.303614519704608	no	1545	0.313614191948374	1036	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION|RESPONSE TO NUTRIENT LEVELS	SITE OF POLARIZED GROWTH|CYTOSKELETON		Amphiphysin-like lipid raft protein; interacts with Rvs167p and regulates polarization of the actin cytoskeleton, endocytosis, cell polarity, cell fusion and viability following starvation or osmotic stress	conjugation with cellular fusion|actin cytoskeleton reorganization|endocytosis|actin cortical patch localization|response to starvation|response to osmotic stress|lipid tube assembly|actin cytoskeleton organization	cytoskeletal protein binding|lipid binding	membrane raft|mating projection tip|mating projection|actin cortical patch
YDR154C_d	YDR154C	YDR154C	hom	Dubious	0.51401075232236	0.303622236598383	no	1546	0.274042313409343	915	NA					Dubious open reading frame, null mutant exhibits synthetic phenotype with alpha-synuclein	Unknown	Unknown	Unknown
YNR034W	YNR034W	SOL1	hom	Verified	0.513427721606073	0.303826079091022	no	1547	0.257248773295249	879	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|RNA LOCALIZATION|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol3p and Sol4p; SOL1 has a paralog, SOL2, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress	tRNA export from nucleus	molecular_function|6-phosphogluconolactonase activity	nucleus|cytoplasm
YMR179W	YMR179W	SPT21	hom	Verified	0.513204692754526	0.303904071838648	no	1548	0.317775919626778	1086	NA	FT	TRANSCRIPTION FROM RNA POL II|GENE SILENCING	NUCLEUS		Protein with a role in transcriptional silencing; required for normal transcription at several loci including HTA2-HTB2 and HHF2-HHT2, but not required at the other histone loci; functionally related to Spt10p; localizes to nuclear foci that become diffuse upon DNA replication stress	chromatin silencing at rDNA|regulation of transcription from RNA polymerase II promoter|chromatin silencing at telomere|chromatin silencing at silent mating-type cassette	molecular_function	nucleus
YBR200W	YBR200W	BEM1	hom	Verified	0.51289838700663	0.304011200901435	no	1549	0.280390714477622	968	NA	FT		SITE OF POLARIZED GROWTH|CYTOSKELETON		Protein containing SH3-domains, involved in establishing cell polarity and morphogenesis; functions as a scaffold protein for complexes that include Cdc24p, Ste5p, Ste20p, and Rsr1p	establishment of cell polarity|cell morphogenesis involved in conjugation with cellular fusion	protein complex scaffold|phosphatidylinositol-3-phosphate binding	incipient cellular bud site|mating projection tip|cellular bud neck|cellular bud tip
YKL194C	YKL194C	MST1	hom	Verified	0.512868500855764	0.304021654350151	no	1550	0.334280311197424	1116	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial threonyl-tRNA synthetase; aminoacylates both the canonical threonine tRNA tT(UGU)Q1 and the unusual threonine tRNA tT(XXX)Q2 in vitro	mitochondrial threonyl-tRNA aminoacylation	threonine-tRNA ligase activity	mitochondrion
YGR289C	YGR289C	MAL11	hom	Verified	0.512630945327771	0.304104751194253	no	1551	0.319909273365298	1079	NA	FT	CARBOHYDRATE METABOLISM	PLASMA MEMBRANE		Inducible high-affinity maltose transporter (alpha-glucoside transporter); encoded in the MAL1 complex locus; broad substrate specificity that includes maltotriose; required for isomaltose utilization	trehalose transport|maltose transport|disaccharide catabolic process	trehalose transmembrane transporter activity|alpha-glucoside:hydrogen symporter activity|maltose:hydrogen symporter activity	integral to membrane|plasma membrane
YIL156W	YIL156W	UBP7	hom	Verified	0.512300561670205	0.304220336110685	no	1552	0.310132352441076	1045	NA	FT	PROTEOLYSIS			Ubiquitin-specific protease that cleaves ubiquitin-protein fusions	protein deubiquitination	ubiquitin-specific protease activity	cytoplasm
YLR184W_d	YLR184W	YLR184W	hom	Dubious	0.511518034374511	0.304494181777459	no	1553	0.281747241915408	998	NA					Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YJL200C	YJL200C	ACO2	hom	Verified	0.51029916933756	0.304920942304147	no	1554	0.268455998671247	910	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Putative mitochondrial aconitase isozyme; similarity to Aco1p, an aconitase required for the TCA cycle; expression induced during growth on glucose, by amino acid starvation via Gcn4p, and repressed on ethanol	biological_process	aconitate hydratase activity	mitochondrion
YJL083W	YJL083W	TAX4	hom	Verified	0.509913908298233	0.305055888783488	no	1555	0.273079135876729	930	NA	FT	LIPID METABOLISM|SIGNALING|CELL WALL ORG/BIOGENESIS|RESPONSE TO NUTRIENT LEVELS			EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; TAX4 has a paralog, IRS4, that arose from the whole genome duplication	autophagy|fungal-type cell wall organization|inositol lipid-mediated signaling|CVT pathway|cellular response to starvation	molecular_function	pre-autophagosomal structure
YML017W	YML017W	PSP2	hom	Verified	0.509749038415716	0.305113646327455	no	1556	0.324660840332691	1122	NA					Asn rich cytoplasmic protein that contains RGG motifs; high-copy suppressor of group II intron-splicing defects of a mutation in MRS2 and of a conditional mutation in POL1 (DNA polymerase alpha); possible role in mitochondrial mRNA splicing	biological_process	molecular_function	cytoplasm
YNL067W	YNL067W	RPL9B	hom	Verified	0.509581034803885	0.305172506679234	no	1557	0.254677098592684	853	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L9B; nearly identical to paralog Rpl9Ap; homologous to mammalian ribosomal protein L9 and bacterial L6	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YGR171C	YGR171C	MSM1	hom	Verified	0.507744210323314	0.305816369739829	no	1558	0.313102413481287	1037	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION	MITOCHONDRION		Mitochondrial methionyl-tRNA synthetase (MetRS), functions as a monomer in mitochondrial protein synthesis; functions similarly to cytoplasmic MetRS although the cytoplasmic form contains a zinc-binding domain not found in Msm1p	methionyl-tRNA aminoacylation	methionine-tRNA ligase activity	mitochondrion
YFL047W	YFL047W	RGD2	hom	Verified	0.507473690789557	0.305911245889215	no	1559	0.311261091207616	1061	NA	FT	SIGNALING	SITE OF POLARIZED GROWTH		GTPase-activating protein (RhoGAP) for Cdc42p and Rho5p; relocalizes from bud neck to cytoplasm upon DNA replication stress	small GTPase mediated signal transduction	Rho GTPase activator activity	cellular bud neck|cytoplasm
YLR461W	YLR461W	PAU4	hom	Verified	0.50718332831509	0.306013095814626	no	1560	0.310923118131997	1058	NA					Member of the seripauperin multigene family encoded mainly in subtelomeric regions; active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme	biological_process	molecular_function	cellular_component
YLR018C	YLR018C	POM34	hom	Verified	0.506705939937687	0.306180581082884	no	1561	0.24921302424168	854	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|CYTOSKELETON ORGANIZATION|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	Subunit of the transmembrane ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis and spindle pole body duplication	nuclear pore organization|protein import into nucleus|spindle pole body duplication associated with nuclear envelope	structural constituent of nuclear pore	nuclear pore transmembrane ring|integral to membrane|integral to nuclear outer membrane|nuclear pore
YBL045C	YBL045C	COR1	hom	Verified	0.506453657472024	0.306269107346664	no	1562	0.316840083740627	1071	NA	FT	OXIDATION-REDUCTION PROCESS|PROTEOLYSIS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Core subunit of the ubiquinol-cytochrome c reductase complex (bc1 complex), which is a component of the mitochondrial inner membrane electron transport chain	aerobic respiration	ubiquinol-cytochrome-c reductase activity	mitochondrion|integral to membrane|mitochondrial respiratory chain complex III
YGL164C	YGL164C	YRB30	hom	Verified	0.506401485737716	0.306287415891539	no	1563	0.305452194270166	1014	NA	FT	PROTEIN LOCALIZATION	NUCLEUS		RanGTP-binding protein, inhibits RanGAP1 (Rna1p)-mediated GTP hydrolysis of RanGTP (Gsp1p); shares similarity to proteins in other fungi but not in higher eukaryotes	biological_process	GTPase regulator activity	nucleus|cytoplasm
YDR466W	YDR466W	PKH3	hom	Verified	0.505947672819985	0.306446692146263	no	1564	0.348532845850186	1190	NA	FF|FT	SIGNALING|CELL WALL ORG/BIOGENESIS|PROTEIN PHOSPHORYLATION			Protein kinase with similarity to mammalian phosphoinositide-dependent kinase 1 (PDK1) and yeast Pkh1p and Pkh2p, two redundant upstream activators of Pkc1p; identified as a multicopy suppressor of a pkh1 pkh2 double mutant	MAPK cascade involved in cell wall biogenesis|protein phosphorylation	protein kinase activity	cellular_component
YCR019W	YCR019W	MAK32	hom	Verified	0.505944199127287	0.306447911461022	no	1565	0.304312868461663	1055	NA					Protein necessary for structural stability of L-A double-stranded RNA-containing particles	interspecies interaction between organisms	molecular_function	cellular_component
YPL025C_d	YPL025C	YPL025C	hom	Dubious	0.50252674535947	0.30764852193964	no	1566	0.315137167624373	1062	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YLR227C	YLR227C	ADY4	hom	Verified	0.502417609057224	0.307686897465245	no	1567	0.284943871547413	952	NA	FT	CELL CYCLE|CELL DIVISION	NUCLEUS|CYTOSKELETON		Structural component of the meiotic outer plaque, which is a membrane-organizing center that assembles on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane	sporulation resulting in formation of a cellular spore	structural molecule activity	spindle pole body
YER053C-A	YER053C-A	YER053C-A	hom	Verified	0.501426084216417	0.308035643048131	no	1568	0.290829419722598	984	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	endoplasmic reticulum
YMR233W	YMR233W	TRI1	hom	Verified	0.501240322129478	0.308100999798339	no	1569	0.321341474662112	1090	NA	FT		NUCLEUS		Non-essential sumoylated protein of unknown function; similar to components of human SWI/SNF complex including SMRD3; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm, nucleus and nucleolus; TRI1 has a paralog, UAF30, that arose from the whole genome duplication	biological_process	molecular_function	nucleolus|nucleus|cytoplasm
YMR063W	YMR063W	RIM9	hom	Verified	0.501170281189906	0.30812564391043	no	1570	0.340599842564935	1173	NA	FF|FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Plasma membrane protein of unknown function; involved in the proteolytic activation of Rim101p in response to alkaline pH; interacts with Rim21p and Dfg16p to form a pH-sensing complex in the Rim101 pathway and is required to maintain Rim21p levels; has similarity to A. nidulans PalI;	ascospore formation	molecular_function	integral to membrane
YOR101W	YOR101W	RAS1	hom	Verified	0.500372734556094	0.308406324043179	no	1571	0.280370286540404	980	NA	FT	SIGNALING|NUCLEOTIDE METABOLISM	PLASMA MEMBRANE		GTPase involved in G-protein signaling in adenylate cyclase activation; plays a role in cell proliferation; localized to the plasma membrane; homolog of mammalian RAS proto-oncogenes; relative distribution to the nucleus increases upon DNA replication stress	adenylate cyclase-activating G-protein coupled receptor signaling pathway|replicative cell aging|Ras protein signal transduction	GTPase activity	plasma membrane
YER002W	YER002W	NOP16	hom	Verified	0.500173737367637	0.308476374479853	no	1572	0.320383191595764	1067	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis	ribosomal large subunit biogenesis	molecular_function	nucleolus|nucleus|preribosome, large subunit precursor
YHR149C	YHR149C	SKG6	hom	Verified	0.499586977152061	0.308682964761325	no	1573	0.311765028666991	1036	NA	FT		SITE OF POLARIZED GROWTH		Integral membrane protein that localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p	biological_process	molecular_function	cell cortex|incipient cellular bud site|integral to membrane|cellular bud neck|cellular bud tip
YOR325W_d	YOR325W	YOR325W	hom	Dubious	0.499263410047395	0.308796914245308	no	1574	0.31188940954348	1083	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF FRT1	Unknown	Unknown	Unknown
YDR453C	YDR453C	TSA2	hom	Verified	0.498964253085492	0.308902283674394	no	1575	0.295579134653364	980	NA	FT	OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS			Stress inducible cytoplasmic thioredoxin peroxidase; cooperates with Tsa1p in the removal of reactive oxygen, nitrogen and sulfur species using thioredoxin as hydrogen donor; deletion enhances the mutator phenotype of tsa1 mutants; protein abundance increases in response to DNA replication stress	cellular response to oxidative stress|cell redox homeostasis	peroxiredoxin activity|thioredoxin peroxidase activity	cytoplasm
YDL129W	YDL129W	YDL129W	hom	Verified	0.498309767814763	0.309132862112443	no	1576	0.271979035827484	913	NA	FT		NUCLEUS		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; YDL129W is not an essential gene; relative distribution to the nucleus increases upon DNA replication stress	biological_process	molecular_function	nucleus|cytoplasm
YMR271C	YMR271C	URA10	hom	Verified	0.497556983970637	0.309398164630543	no	1577	0.28891911694491	976	NA	FT	NUCLEOTIDE METABOLISM			Minor orotate phosphoribosyltransferase (OPRTase) isozyme; catalyzes the fifth enzymatic step in the de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; URA10 has a paralog, URA5, that arose from the whole genome duplication	'de novo' pyrimidine nucleobase biosynthetic process|pyrimidine ribonucleoside biosynthetic process	orotate phosphoribosyltransferase activity	cytoplasm
YOL080C	YOL080C	REX4	hom	Verified	0.496981699301516	0.309600978376925	no	1578	0.290531831180145	982	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Putative RNA exonuclease possibly involved in pre-rRNA processing and ribosome assembly	ribosomal large subunit assembly|rRNA processing	3'-5' exonuclease activity	nucleolus|nucleus
YOR127W	YOR127W	RGA1	hom	Verified	0.496951537599324	0.309611613335326	no	1579	0.319510081366991	1076	NA	FT	SIGNALING|CELL DIVISION|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		GTPase-activating protein for polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth; relocalizes from bud neck to cytoplasm upon DNA replication stress	budding cell isotropic bud growth|pheromone-dependent signal transduction involved in conjugation with cellular fusion|pseudohyphal growth|actin filament organization|establishment of cell polarity|small GTPase mediated signal transduction|invasive growth in response to glucose limitation|budding cell apical bud growth	Rho GTPase activator activity	cellular bud neck split septin rings
YGR197C	YGR197C	SNG1	hom	Verified	0.496573855833006	0.309744796695526	no	1580	0.297020041762852	1013	NA	FT		PLASMA MEMBRANE		Protein involved in resistance to nitrosoguanidine (MNNG) and 6-azauracil (6-AU); expression is regulated by transcription factors involved in multidrug resistance	nucleobase-containing compound transport	molecular_function	integral to membrane|plasma membrane
YOL107W_p	YOL107W	YOL107W	hom	Uncharacterized	0.495831070841034	0.310006800659093	no	1581	0.300813431444836	1031	NA	FT		ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and colocalizes in a punctate pattern with the early golgi/COPI vesicles; YOL107W is not an essential protein	biological_process	molecular_function	COPI-coated vesicle|Golgi apparatus
YIL090W	YIL090W	ICE2	hom	Verified	0.495426905576738	0.310149403193268	no	1582	0.319310486019406	1105	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Integral ER membrane protein with type-III transmembrane domains; required for maintenance of ER zinc homeostasis; necessary for efficient targeting of Trm1p tRNA methyltransferase to inner nuclear membrane; mutations cause defects in cortical ER morphology in both the mother and daughter cells	endoplasmic reticulum inheritance	molecular_function	integral to endoplasmic reticulum membrane|integral to membrane|endoplasmic reticulum
YNL196C_p	YNL196C	SLZ1	hom	Uncharacterized	0.49402756156845	0.310643357357357	no	1583	0.319204593782475	1109	NA					Sporulation-specific protein with a leucine zipper motif	biological_process	molecular_function	cellular_component
YER099C	YER099C	PRS2	hom	Verified	0.493898749102121	0.310688844024997	no	1584	0.291100082894819	986	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM			5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; PRS2 has a paralog, PRS4, that arose from the whole genome duplication	fungal-type cell wall organization|5-phosphoribose 1-diphosphate biosynthetic process	ribose phosphate diphosphokinase activity	cytoplasm
YBR221W-A_p	YBR221W-A	YBR221W-A	hom	Uncharacterized	0.49343980496307	0.310850931358206	no	1585	0.307180853271532	1015	NA					Putative protein of unknown function; identified by expression profiling and mass spectrometry	biological_process	molecular_function	cellular_component
YMR255W	YMR255W	GFD1	hom	Verified	0.492619765507005	0.311140639705308	no	1586	0.30452307996332	1038	NA	FT	PROTEIN LOCALIZATION|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	Coiled-coiled protein of unknown function; identified as a high-copy suppressor of a dbp5 mutation; protein abundance increases in response to DNA replication stress	mRNA export from nucleus	molecular_function	integral to membrane|nuclear pore|cytoplasm
YHL041W_d	YHL041W	YHL041W	hom	Dubious	0.491341019197303	0.311592636231019	no	1587	0.278238613752419	958	NA					Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data	Unknown	Unknown	Unknown
YMR284W	YMR284W	YKU70	hom	Verified	0.490897898454306	0.311749331755773	no	1588	0.289553895803349	1002	NA	FT	CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING	ENDOMEMBRANE SYSTEM|NUCLEUS|CHROMOSOME		Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair	chromatin assembly or disassembly|chromatin silencing|double-strand break repair via nonhomologous end joining|telomere maintenance|double-strand break repair via break-induced replication|double-strand break repair via homologous recombination|chromatin silencing at silent mating-type cassette	damaged DNA binding|RNA binding	nuclear chromatin|nuclear telomeric heterochromatin|nuclear envelope|Ku70:Ku80 complex
YPL178W	YPL178W	CBC2	hom	Verified	0.490380196232104	0.311932443819823	no	1589	0.274796750443102	934	NA	FT	RNA PROCESSING|RNA LOCALIZATION	NUCLEUS		Small subunit of the heterodimeric cap binding complex that also contains Sto1p, component of the spliceosomal commitment complex; interacts with Npl3p, possibly to package mRNA for export from the nucleus; contains an RNA-binding motif	mRNA splicing, via spliceosome	RNA cap binding	commitment complex|nuclear cap binding complex
YDL009C_p	YDL009C	YDL009C	hom	Uncharacterized	0.487605223781965	0.312914747380682	no	1590	0.310593573931975	1035	NA					Protein of unknown function; mRNA identified as translated by ribosome profiling data; partially overlaps the verified ORF YDL010W; YDL009C is not an essential gene	biological_process	molecular_function	cellular_component
YNR048W	YNR048W	YNR048W	hom	Verified	0.486819629632555	0.313193079140422	no	1591	0.314271139701028	1073	NA					Protein that interacts with phospholipid translocase (flippase) Dnf3p; YNR048W has a paralog, CDC50, that arose from the whole genome duplication	response to drug	phospholipid-translocating ATPase activity	integral to membrane
YJL088W	YJL088W	ARG3	hom	Verified	0.486504732853165	0.313304675265181	no	1592	0.325901578227292	1104	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Ornithine carbamoyltransferase (carbamoylphosphate:L-ornithine carbamoyltransferase), catalyzes the sixth step in the biosynthesis of the arginine precursor ornithine	arginine biosynthetic process|ornithine metabolic process	ornithine carbamoyltransferase activity	cytosol
YBR084W	YBR084W	MIS1	hom	Verified	0.485841681702053	0.313539709550219	no	1593	0.295070647839038	1021	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM	MITOCHONDRION		Mitochondrial C1-tetrahydrofolate synthase, involved in interconversion between different oxidation states of tetrahydrofolate (THF); provides activities of formyl-THF synthetase, methenyl-THF cyclohydrolase, and methylene-THF dehydrogenase	nucleobase-containing compound metabolic process|folic acid biosynthetic process	formate-tetrahydrofolate ligase activity|methylenetetrahydrofolate dehydrogenase (NADP+) activity|methenyltetrahydrofolate cyclohydrolase activity	mitochondrion
YMR032W	YMR032W	HOF1	hom	Verified	0.485337054334475	0.313718637500504	no	1594	0.318402510828834	1076	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CELL DIVISION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Bud neck-localized, SH3 domain-containing protein required for cytokinesis; is phosphorylated by Dbf2p; regulates actomyosin ring dynamics and septin localization; interacts with the formins, Bni1p and Bnr1p, and with Cyk3p, Vrp1p, and Bni5p	cytokinesis after mitosis|barrier septum assembly involved in cell cycle cytokinesis|response to DNA damage stimulus|cytokinesis	cytoskeletal protein binding	cellular bud neck contractile ring|cellular bud neck septin ring
YLL045C	YLL045C	RPL8B	hom	Verified	0.482763308837632	0.314631902851752	no	1595	0.289424681449816	994	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L8B; mutation results in decreased amounts of free 60S subunits; homologous to mammalian ribosomal protein L7A, no bacterial homolog; RPL8B has a paralog, RPL8A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YIL110W	YIL110W	HPM1	hom	Verified	0.481259075310889	0.315166189646002	no	1596	0.308643518771644	1033	NA	FT		NUCLEUS		AdoMet-dependent methyltransferase involved in a novel 3-methylhistidine modification of ribosomal protein Rpl3p; seven beta-strand MTase family member; null mutant exhibits a weak vacuolar protein sorting defect and caspofungin resistance	peptidyl-histidine methylation, to form tele-methylhistidine	S-adenosylmethionine-dependent methyltransferase activity|protein-histidine N-methyltransferase activity	nucleus|cytoplasm
YPL097W	YPL097W	MSY1	hom	Verified	0.481140821975887	0.315208208314225	no	1597	0.326518770665895	1086	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial tyrosyl-tRNA synthetase	mitochondrial tyrosyl-tRNA aminoacylation	tyrosine-tRNA ligase activity	mitochondrion
YDR210W_p	YDR210W	YDR210W	hom	Uncharacterized	0.47995159485886	0.315630906318368	no	1598	0.269646535565105	928	NA	FT		PLASMA MEMBRANE		Predicted tail-anchored plasma membrane protein containing a conserved CYSTM module; related proteins in other organisms may be involved in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery	biological_process	molecular_function	cellular_component
YDR525W_d	YDR525W	API2	hom	Dubious	0.479241488555743	0.315883421080459	no	1599	0.358222262195692	1188	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 26% of ORF overlaps the dubious ORF YDR524C-A; insertion mutation in a cdc34-2 mutant background causes altered bud morphology	Unknown	Unknown	Unknown
YDR488C	YDR488C	PAC11	hom	Verified	0.479192609922941	0.315900805551183	no	1600	0.278631660992457	948	NA	FT		CYTOSKELETON		Dynein intermediate chain, acts in the cytoplasmic dynein pathway, forms cortical cytoplasmic microtubule capture site with Num1p; null mutant is defective in nuclear migration, essential in the absence of CIN8	nuclear migration along microtubule|microtubule-based process	plus-end-directed microtubule motor activity|microtubule motor activity	cytoplasmic dynein complex|cytoplasmic microtubule
YBR245C	YBR245C	ISW1	hom	Verified	0.478816544184342	0.31603457298648	no	1601	0.305043738633588	1040	NA	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS|CHROMOSOME		ATPase subunit of imitation-switch (ISWI) class chromatin remodelers; ATPase; forms a complex with Ioc3p (Isw1a), and a complex with Ioc2p and Ioc4p (Isw1b); Isw1a and Isw1b have partially overlapping and distinct roles, Isw1a involved in repression of transcription initiation and Isw1b involved in regulation of transcription elongation; Isw1b recruited to open reading frames by H3K36 methylation and acts with Chd1p to prevent trans-histone exchange over coding regions	termination of RNA polymerase I transcription|nucleosome positioning|termination of RNA polymerase II transcription|regulation of transcription by chromatin organization|DNA-dependent transcription, elongation|regulation of transcriptional start site selection at RNA polymerase II promoter|heterochromatin maintenance involved in chromatin silencing|chromatin remodeling|positive regulation of transcription from RNA polymerase II promoter	nucleosome binding|ATPase activity|rDNA binding|DNA binding	ISW1 complex|nucleolar chromatin
YNL010W_p	YNL010W	YNL010W	hom	Uncharacterized	0.476689484840297	0.316791625835701	no	1602	0.341012654889423	1170	NA	FT		NUCLEUS		Putative protein of unknown function with similarity to phosphoserine phosphatases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; homozygous diploid mutant shows an increase in glycogen accumulation	biological_process	molecular_function	nucleus|cytoplasm
YOL067C	YOL067C	RTG1	hom	Verified	0.475625745228558	0.317170515222587	no	1603	0.338867189779809	1125	NA	FT	TRANSCRIPTION FROM RNA POL II|SIGNALING	NUCLEUS		Transcription factor (bHLH) involved in interorganelle communication between mitochondria, peroxisomes, and nucleus	cellular response to oleic acid|positive regulation of transcription from RNA polymerase II promoter|mitochondria-nucleus signaling pathway	sequence-specific DNA binding RNA polymerase II transcription factor activity	nucleus|cytoplasm
YCR088W	YCR088W	ABP1	hom	Verified	0.474722305956521	0.317492458430425	no	1604	0.30765546053233	1016	NA	FT	PROTEIN LOCALIZATION|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Actin-binding protein of the cortical actin cytoskeleton, important for activation of the Arp2/3 complex that plays a key role actin in cytoskeleton organization; phosphorylation within its PRR (Proline-Rich Region), mediated by Cdc28p and Pho85p, protects Abp1p from proteolysis mediated by its own PEST sequences	protein localization|actin cortical patch assembly	actin filament binding	cell cortex|mating projection tip|cytoplasm|actin cortical patch
YDR440W	YDR440W	DOT1	hom	Verified	0.473974599311237	0.317759010321288	no	1605	0.32151307937497	1099	NA	FT	CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING	NUCLEUS		Nucleosomal histone H3-Lys79 methylase; methylation is required for telomeric silencing, meiotic checkpoint control, and DNA damage response	meiotic recombination checkpoint|postreplication repair|recombinational repair|global genome nucleotide-excision repair|nucleotide-excision repair|DNA damage checkpoint|chromatin silencing at telomere|histone H3-K79 methylation	nucleosomal histone binding|histone methyltransferase activity (H3-K79 specific)	nucleus
YAR003W	YAR003W	SWD1	hom	Verified	0.472755577302498	0.318193785188035	no	1606	0.351142700632546	1184	NA	FT	CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS|CHROMOSOME		Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member with similarity to mammalian Rbbp7	histone H3-K4 methylation|telomere maintenance|regulation of transcription, DNA-dependent|chromatin silencing at telomere	histone methyltransferase activity (H3-K4 specific)	Set1C/COMPASS complex
YHL047C	YHL047C	ARN2	hom	Verified	0.471649802753247	0.318588386159279	no	1607	0.316361063445698	1055	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|COFACTOR METABOLISM	PLASMA MEMBRANE		Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to the siderophore triacetylfusarinine C	cellular iron ion homeostasis|siderophore transport|siderophore metabolic process	siderophore transmembrane transporter activity	endosome|integral to membrane|cytoplasmic membrane-bounded vesicle|plasma membrane
YDL062W_d	YDL062W	YDL062W	hom	Dubious	0.470832382524965	0.318880218855339	no	1608	0.325074010982295	1098	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized ORF YDL063C; YDL062W is not essential	Unknown	Unknown	Unknown
YML041C	YML041C	VPS71	hom	Verified	0.470258224182956	0.319085270163243	no	1609	0.337455662637247	1140	NA	FF|FT	PROTEIN LOCALIZATION|CHROMATIN ORGANIZATION|VACUOLAR TRANSPORT	NUCLEUS|CHROMOSOME		Nucleosome-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting	chromatin remodeling|protein targeting to vacuole|histone exchange	nucleosome binding	Swr1 complex|nucleus
YDR282C_p	YDR282C	YDR282C	hom	Uncharacterized	0.469891188005758	0.319216380176476	no	1610	0.297155638101345	988	NA					Putative protein of unknown function; localizes to the inner mitochondrial membrane with the C terminus facing the intermembrane space; ortholog of human RMND1, mutation in which is implicated in infantile encephaloneuromyopathy and defective mitochondrial translation	biological_process	molecular_function	cellular_component
YMR125W	YMR125W	STO1	hom	Verified	0.469881048616674	0.319220002416888	no	1611	0.323598834570429	1075	NA	FT	RNA PROCESSING|RNA LOCALIZATION	NUCLEUS		Large subunit of the nuclear mRNA cap-binding protein complex, interacts with Npl3p to carry nuclear poly(A)+ mRNA to cytoplasm; also involved in nuclear mRNA degradation and telomere maintenance; orthologous to mammalian CBP80	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|mRNA splicing, via spliceosome|response to osmotic stress	mRNA binding	commitment complex|nuclear cap binding complex|polysome
YDR332W	YDR332W	IRC3	hom	Verified	0.469862184148128	0.319226741689381	no	1612	0.318108764686666	1078	NA	FT		MITOCHONDRION		Putative RNA helicase of the DEAH/D-box family; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion	biological_process	ATP-dependent RNA helicase activity	mitochondrion
YAL068C	YAL068C	PAU8	hom	Verified	0.469859838522454	0.319227579661006	no	1613	0.301140536320847	1030	NA	FT	TRANSCRIPTION FROM RNA POL II			Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions	ascospore formation|positive regulation of transcription from RNA polymerase II promoter	molecular_function	cellular_component
YEL012W	YEL012W	UBC8	hom	Verified	0.469576528501199	0.319328798577143	no	1614	0.315362219618898	1030	NA	FT	KETONE METABOLISM|CARBOHYDRATE METABOLISM|PROTEOLYSIS			Ubiquitin-conjugating enzyme that negatively regulates gluconeogenesis by mediating the glucose-induced ubiquitination of fructose-1,6-bisphosphatase (FBPase); cytoplasmic enzyme that catalyzes the ubiquitination of histones in vitro	negative regulation of gluconeogenesis|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein polyubiquitination|protein monoubiquitination	ubiquitin-protein ligase activity	cytoplasm
YOR348C	YOR348C	PUT4	hom	Verified	0.469537822837366	0.319342628097141	no	1615	0.331380497260359	1107	NA	FT		PLASMA MEMBRANE		Proline permease, required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells	neutral amino acid transport|proline transport|gamma-aminobutyric acid transport	neutral amino acid transmembrane transporter activity|L-proline transmembrane transporter activity	integral to membrane|plasma membrane
YDL046W	YDL046W	NPC2	hom	Verified	0.469516256984073	0.319350333677928	no	1616	0.311140316888276	1044	NA					Functional homolog of human NPC2/He1, which is a cholesterol-binding protein whose deficiency causes Niemann-Pick type C2 disease involving retention of cholesterol in lysosomes	intracellular sterol transport	molecular_function	fungal-type vacuole lumen|fungal-type vacuole
YJL127C-B_p	YJL127C-B	YJL127C-B	hom	Uncharacterized	0.469458686007019	0.319370904440888	no	1617	0.305184777681998	1033	NA					Putative protein of unknown function; identified based on homology to the filamentous fungus, <i>Ashbya gossypii</i>	biological_process	molecular_function	cellular_component
YLR435W	YLR435W	TSR2	hom	Verified	0.468838601777632	0.319592502800402	no	1618	0.331280221804651	1134	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Protein with a potential role in pre-rRNA processing	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	molecular_function	nucleus|cytoplasm
YPL259C	YPL259C	APM1	hom	Verified	0.468506498954311	0.319711212274419	no	1619	0.340447039942875	1146	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Mu1-like medium subunit of the clathrin-associated protein complex (AP-1); binds clathrin; involved in clathrin-dependent Golgi protein sorting	Golgi to vacuole transport|vesicle-mediated transport	clathrin binding	AP-1 adaptor complex
YLR412W	YLR412W	BER1	hom	Verified	0.46824865207655	0.319803391851535	no	1620	0.313330382270907	1091	NA	FT		CYTOSKELETON		Protein involved in microtubule-related processes, N-acetylation; GFP-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YLR412W is not an essential gene; similar to Arabidopsis SRR1 gene	biological_process	molecular_function	cytoplasm
YIL096C_p	YIL096C	YIL096C	hom	Uncharacterized	0.468104780398548	0.319854830434109	no	1621	0.313721685311854	1048	NA	FT		NUCLEUS		Putative S-adenosylmethionine-dependent methyltransferase; associates with precursors of the 60S ribosomal subunit; predicted to be involved in ribosome biogenesis	biological_process	S-adenosylmethionine-dependent methyltransferase activity	nucleolus|nucleus
YMR318C	YMR318C	ADH6	hom	Verified	0.467780773999076	0.319970685445679	no	1622	0.306844807967053	1036	NA	FT	OXIDATION-REDUCTION PROCESS			NADPH-dependent medium chain alcohol dehydrogenase; has broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance; protein abundance increases in response to DNA replication stress	cellular aldehyde metabolic process|furaldehyde metabolic process|alcohol metabolic process	hydroxymethylfurfural reductase (NADH) activity|hydroxymethylfurfural reductase (NADPH) activity|alcohol dehydrogenase (NADP+) activity	cellular_component
YNR045W	YNR045W	PET494	hom	Verified	0.465384294189904	0.320828139710785	no	1623	0.29765302065534	1044	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet122p; located in the mitochondrial inner membrane	mitochondrial respiratory chain complex IV biogenesis|positive regulation of mitochondrial translation	translation regulator activity	mitochondrion|mitochondrial inner membrane
YLR365W_d	YLR365W	YLR365W	hom	Dubious	0.465295634801295	0.320859880188271	no	1624	0.292843213681813	983	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps dubious gene YLR364C-A; YLR365W is not an essential gene	Unknown	Unknown	Unknown
YIL124W	YIL124W	AYR1	hom	Verified	0.46498462501893	0.320971233502758	no	1625	0.322315577220423	1078	NA	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS	ENDOPLASMIC RETICULUM|MITOCHONDRION		NADPH-dependent 1-acyl dihydroxyacetone phosphate reductase found in lipid particles, ER, and mitochondrial outer membrane; involved in phosphatidic acid biosynthesis; required for spore germination; capable of metabolizing steroid hormones	phosphatidic acid biosynthetic process	acylglycerone-phosphate reductase activity	mitochondrial outer membrane|mitochondrion|integral to membrane|endoplasmic reticulum|lipid particle|cytoplasm
YBR021W	YBR021W	FUR4	hom	Verified	0.463124783587746	0.321637463185744	no	1626	0.366130533489097	1252	NA	FF|FT		PLASMA MEMBRANE		Plasma membrane localized uracil permease; expression is tightly regulated by uracil levels and environmental cues; conformational alterations induced by unfolding or substrate binding result in Rsp5p-mediated ubiquitination and degradation	uracil transport|transmembrane transport	uracil:cation symporter activity	integral to membrane|membrane raft|plasma membrane
YML076C	YML076C	WAR1	hom	Verified	0.462859018136646	0.321732712219663	no	1627	0.296992455207122	1017	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS|MITOCHONDRION		Homodimeric Zn2Cys6 zinc finger transcription factor; binds to a weak acid response element to induce transcription of PDR12 and FUN34, encoding an acid transporter and a putative ammonia transporter, respectively	response to acid	sequence-specific DNA binding transcription factor activity	mitochondrion|nucleus
YHR066W	YHR066W	SSF1	hom	Verified	0.462445080090289	0.321881088920811	no	1628	0.299557577657203	1010	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS	NUCLEUS		Constituent of 66S pre-ribosomal particles; required for ribosomal large subunit maturation; functionally redundant with Ssf2p; member of the Brix family; SSF1 has a paralog, SSF2, that arose from the whole genome duplication	conjugation with cellular fusion|ribosomal large subunit assembly|regulation of cell size	rRNA binding	nucleolus
YGL168W	YGL168W	HUR1	hom	Verified	0.462416767943633	0.321891238489491	no	1629	0.392013373711659	1305	NA	FF|FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS			Protein of unknown function; reported null mutant phenotype of hydroxyurea sensitivity may be due to effects on overlapping PMR1 gene	DNA replication	molecular_function	cellular_component
YPL054W	YPL054W	LEE1	hom	Verified	0.461822210946049	0.322104410804715	no	1630	0.292419548611673	1007	NA					Zinc-finger protein of unknown function	biological_process	molecular_function	cellular_component
YHL004W	YHL004W	MRP4	hom	Verified	0.461489066401774	0.322223881959716	no	1631	0.328209886236649	1089	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the small subunit	mitochondrial translation	structural constituent of ribosome|tRNA binding	mitochondrion|mitochondrial small ribosomal subunit
YPL250C	YPL250C	ICY2	hom	Verified	0.461114996602635	0.322358051481559	no	1632	0.351778747233101	1198	NA					Protein of unknown function; mobilized into polysomes upon a shift from a fermentable to nonfermentable carbon source; potential Cdc28p substrate	mitochondrion degradation	molecular_function	cellular_component
YBL064C	YBL064C	PRX1	hom	Verified	0.46016058198762	0.322700481062818	no	1633	0.285934166915172	953	NA	FT	OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS	MITOCHONDRION		Mitochondrial peroxiredoxin with thioredoxin peroxidase activity; has a role in reduction of hydroperoxides; reactivation requires Trr2p and glutathione; induced during respiratory growth and oxidative stress; phosphorylated; protein abundance increases in response to DNA replication stress	response to cadmium ion|cellular response to oxidative stress|cell redox homeostasis	thioredoxin peroxidase activity	mitochondrion
YMR192W	YMR192W	GYL1	hom	Verified	0.459657896861697	0.322880897403919	no	1634	0.312036895920316	1045	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING|NUCLEOTIDE METABOLISM	MITOCHONDRION|GOLGI APPARATUS|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Putative GTPase activating protein (GAP) with a role in exocytosis; stimulates Gyp5p GAP activity on Ypt1p, colocalizes with Gyp5p at sites of polarized growth; interacts with Gyp5p, Rvs161p, and Rvs167p; involved in recruiting Rvs167p to the bud tip during polarized growth; increases in abundance and relocalizes from bud neck to cytoplasm upon DNA replication stress	ER to Golgi vesicle-mediated transport|regulation of exocytosis	protein binding	mitochondrion|incipient cellular bud site|cellular bud|cellular bud neck|cellular bud tip|cytoplasm|Golgi-associated vesicle|plasma membrane
YBL104C	YBL104C	SEA4	hom	Verified	0.459428665055112	0.322963183750761	no	1635	0.424515998313391	1408	NA					Subunit of the SEA (Seh1-associated) complex, a coatomer-related complex that associates dynamically with the vacuole; has an N-terminal beta-propeller fold and a C-terminal RING motif; promoter contains multiple GCN4 binding sites	biological_process	molecular_function	Seh1-associated complex|extrinsic to fungal-type vacuolar membrane|cytoplasm
YPR197C_d	YPR197C	YPR197C	hom	Dubious	0.459388265632672	0.32297768665449	no	1636	0.366305984036468	1207	NA	FF				Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YMR133W	YMR133W	REC114	hom	Verified	0.459281179789873	0.323016130478327	no	1637	0.286420625262972	989	NA	FT	CELL CYCLE	NUCLEUS|CHROMOSOME		Protein involved in early stages of meiotic recombination; possibly involved in the coordination of recombination and meiotic division; mutations lead to premature initiation of the first meiotic division	meiotic DNA double-strand break formation|reciprocal meiotic recombination	molecular_function	condensed nuclear chromosome
YDR256C	YDR256C	CTA1	hom	Verified	0.459250633317734	0.323027097010235	no	1638	0.317635027765931	1077	NA	FT	OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS	MITOCHONDRION		Catalase A, breaks down hydrogen peroxide in the peroxisomal matrix formed by acyl-CoA oxidase (Pox1p) during fatty acid beta-oxidation	response to reactive oxygen species|age-dependent response to reactive oxygen species|hydrogen peroxide catabolic process	catalase activity	peroxisomal matrix|mitochondrial matrix
YDR072C	YDR072C	IPT1	hom	Verified	0.458537848749003	0.323283038462178	no	1639	0.322260432667507	1100	NA	FT	LIPID METABOLISM			Inositolphosphotransferase, involved in synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C), the most abundant sphingolipid; can mutate to resistance to the antifungals syringomycin E and DmAMP1 and to K. lactis zymocin	mannosyl diphosphorylinositol ceramide metabolic process|sphingolipid biosynthetic process	transferase activity, transferring phosphorus-containing groups	integral to membrane
YLL005C	YLL005C	SPO75	hom	Verified	0.457177624878879	0.323771689752738	no	1640	0.293900794095646	976	NA	FT	CELL WALL ORG/BIOGENESIS			Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis	ascospore wall assembly|ascospore formation	molecular_function	integral to membrane
YBR277C_d	YBR277C	YBR277C	hom	Dubious	0.456094960529648	0.32416084694233	no	1641	0.33207374493804	1134	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR278W	Unknown	Unknown	Unknown
YHR022C-A_p	YHR022C-A	YHR022C-A	hom	Uncharacterized	0.456008477786935	0.324191940939052	no	1642	0.318960380126961	1083	NA					Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching	biological_process	molecular_function	cellular_component
YHR108W	YHR108W	GGA2	hom	Verified	0.455962693019751	0.324208402886155	no	1643	0.319532405638689	1116	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEOLYSIS|VACUOLAR TRANSPORT	GOLGI APPARATUS		Protein that interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner to facilitate traffic through the late Golgi; binds phosphatidylinositol 4-phosphate, which plays a role in TGN localization; has homology to gamma-adaptin	protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|Golgi to vacuole transport|Golgi to endosome transport	ubiquitin binding|phosphatidylinositol-4-phosphate binding	trans-Golgi network
YHR104W	YHR104W	GRE3	hom	Verified	0.454664621422542	0.324675268384135	no	1644	0.323888574579384	1078	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		Aldose reductase; involved in methylglyoxal, d-xylose, arabinose, and galactose metabolism; stress induced (osmotic, ionic, oxidative, heat shock, starvation and heavy metals); regulated by the HOG pathway; protein abundance increases in response to DNA replication stress	galactose catabolic process|cellular response to oxidative stress|arabinose catabolic process|D-xylose catabolic process|response to stress	D-xylose:NADP reductase activity|mRNA binding|glucose 1-dehydrogenase (NADP+) activity|alditol:NADP+ 1-oxidoreductase activity	nucleus|cytoplasm
YKL070W_p	YKL070W	YKL070W	hom	Uncharacterized	0.453312361491412	0.325161916411807	no	1645	0.294037909991361	992	NA	FT	OXIDATION-REDUCTION PROCESS	MITOCHONDRION		Putative protein of unknown function; expression induced in cells treated with mycotoxins patulin or citrinin; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YGL175C	YGL175C	SAE2	hom	Verified	0.452516253198776	0.325448557532722	no	1646	0.306500540349886	1044	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS		Endonuclease that processes hairpin DNA structures with the MRX complex; involved in meiotic and mitotic double-strand break repair; phosphorylated in response to DNA damage and required for normal resistance to DNA-damaging agents	DNA double-strand break processing|DNA catabolic process, endonucleolytic|meiotic DNA double-strand break formation|meiotic DNA double-strand break processing|gene conversion at mating-type locus, DNA double-strand break processing	double-stranded DNA binding|single-stranded DNA specific endodeoxyribonuclease activity	nucleus|cytoplasm
YDR275W	YDR275W	BSC2	hom	Verified	0.452335053549533	0.325513813431031	no	1647	0.333113825753928	1104	NA					Protein of unknown function; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; BSC2 has a paralog, IRC23, that arose from the whole genome duplication	biological_process	molecular_function	lipid particle
YPL183C	YPL183C	RTT10	hom	Verified	0.451037762728608	0.325981166257914	no	1648	0.332012411947961	1115	NA	FT	VESICLE-MEDIATED TRANSPORT			WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rrt2p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; evidence it interacts with Trm7p for 2'-O-methylation of N34 of substrate tRNAs; has a role in regulation of Ty1 transposition; human ortholog is WDR6	endocytic recycling	molecular_function	endosome|cytoplasm
YMR315W	YMR315W	YMR315W	hom	Verified	0.450854138512687	0.326047339534531	no	1649	0.331847933941212	1131	NA	FT	OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM	NUCLEUS		Protein with NADP(H) oxidoreductase activity; transcription is regulated by Stb5p in response to NADPH depletion induced by diamide; promoter contains a putative Stb5p binding site; protein abundance increases in response to DNA replication stress	NADPH regeneration	oxidoreductase activity	nucleus|cytoplasm
YML029W	YML029W	USA1	hom	Verified	0.450318488658431	0.326240404769129	no	1650	0.313410360021708	1055	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|PROTEOLYSIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	UBIQUITIN LIGASE COMPLEX	Scaffold subunit of the Hrd1p ubiquitin ligase that also promotes ligase oligomerization; involved in ER-associated protein degradation (ERAD); interacts with the U1 snRNP-specific protein, Snp1p	ER-associated protein catabolic process|mRNA splicing, via spliceosome|positive regulation of protein oligomerization	protein complex scaffold	Hrd1p ubiquitin ligase ERAD-L complex|endoplasmic reticulum membrane
YJL216C	YJL216C	IMA5	hom	Verified	0.44972995475424	0.326452584794683	no	1651	0.33929390103023	1141	NA	FT	CARBOHYDRATE METABOLISM			Alpha-glucosidase; specificity for isomaltose, maltose, and palatinose, but not alpha-methylglucoside; member of the IMA isomaltase family; not required for isomaltose utilization, but Ima5p overexpression allows the ima1 null mutant to grow on isomaltose	disaccharide catabolic process	oligo-1,6-glucosidase activity	cellular_component
YPL136W_d	YPL136W	YPL136W	hom	Dubious	0.449719949379258	0.326456192448494	no	1652	0.326566956547876	1121	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene GIP3/YPL137C	Unknown	Unknown	Unknown
YGR204W	YGR204W	ADE3	hom	Verified	0.449353889698365	0.326588194323092	no	1653	0.310806813285513	1043	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM	NUCLEUS		Cytoplasmic trifunctional enzyme C1-tetrahydrofolate synthase, involved in single carbon metabolism and required for biosynthesis of purines, thymidylate, methionine, and histidine; null mutation causes auxotrophy for adenine and histidine	purine nucleobase biosynthetic process|folic acid-containing compound metabolic process	methylenetetrahydrofolate dehydrogenase (NADP+) activity|formate-tetrahydrofolate ligase activity|methenyltetrahydrofolate cyclohydrolase activity	nucleus|cytoplasm
YBR072W	YBR072W	HSP26	hom	Verified	0.448157056352683	0.327019926377353	no	1654	0.31903099153791	1073	NA	FT		NUCLEUS		Small heat shock protein (sHSP) with chaperone activity; forms hollow, sphere-shaped oligomers that suppress unfolded proteins aggregation; oligomer activation requires heat-induced conformational change; also has mRNA binding activity	protein folding|response to stress	unfolded protein binding|mRNA binding	nucleus|cytoplasm
YPL032C	YPL032C	SVL3	hom	Verified	0.448126204104665	0.32703105873113	no	1655	0.359461794405891	1200	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|OXIDATION-REDUCTION PROCESS	SITE OF POLARIZED GROWTH		Protein of unknown function; mutant phenotype suggests a potential role in vacuolar function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; relocalizes from bud neck to cytoplasm upon DNA replication stress	endocytosis	molecular_function	cellular bud|cellular bud neck|cytoplasm
YML009W-B_d	YML009W-B	YML009W-B	hom	Dubious	0.44806072604883	0.327054685554522	no	1656	0.331694208351499	1138	NA					Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion mutation confers an increase in Ty1 transposition	Unknown	Unknown	Unknown
YNL011C_p	YNL011C	YNL011C	hom	Uncharacterized	0.448036658392221	0.327063370199674	no	1657	0.286087430337127	1009	NA					Putative protein of unknown function; YNL011C is not an essential gene	biological_process	molecular_function	cellular_component
YGR233C	YGR233C	PHO81	hom	Verified	0.447523484610918	0.327248567640667	no	1658	0.339356696408606	1119	NA	FT	LIPID METABOLISM	NUCLEUS		Cyclin-dependent kinase (CDK) inhibitor; regulates Pho80p-Pho85p and Pcl7p-Pho85p cyclin-CDK complexes in response to phosphate levels; inhibitory activity for Pho80p-Pho85p requires myo-D-inositol heptakisphosphate (IP7) generated by Vip1p; relative distribution to the nucleus increases upon DNA replication stress	phosphate-containing compound metabolic process	cyclin-dependent protein kinase inhibitor activity	nucleus|cytoplasm
YPL145C	YPL145C	KES1	hom	Verified	0.446730777669421	0.327534728388055	no	1659	0.331154394227064	1110	NA	FT	VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|MEMBRANE ORGANIZATION	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		One of seven members of the yeast oxysterol binding protein family; involved in negative regulation of Sec14p-dependent Golgi complex secretory functions, peripheral membrane protein that localizes to the Golgi complex; KES1 has a paralog, HES1, that arose from the whole genome duplication	post-Golgi vesicle-mediated transport|positive regulation of phosphatase activity|maintenance of cell polarity|endocytosis|exocytosis|sterol transport	phosphatidic acid binding|lipid binding|phosphatidylinositol-4,5-bisphosphate binding|oxysterol binding|sterol transporter activity|phosphatidylinositol-4-phosphate binding	Golgi membrane|extrinsic to membrane|cytoplasm
YBR179C	YBR179C	FZO1	hom	Verified	0.446458269326888	0.327633125097071	no	1660	0.333352385013643	1103	NA	FT	MEMBRANE ORGANIZATION|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitofusin; integral membrane protein involved in mitochondrial outer membrane tethering and fusion; role in mitochondrial genome maintenance; efficient tethering and degradation of Fzo1p requires an intact N-terminal GTPase domain; targeted for destruction by the ubiquitin ligase SCF-Mdm30p and the cytosolic ubiquitin-proteasome system	mitochondrial fusion	GTPase activity|protein homodimerization activity	mitochondrial outer membrane|mitochondrion|mitochondrial inner membrane|integral to mitochondrial outer membrane
YMR184W	YMR184W	ADD37	hom	Verified	0.446176545620402	0.327734861855388	no	1661	0.324362701596615	1078	NA	FT	PROTEOLYSIS			Protein of unknown function; involved in ER-associated protein degradation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YMR184W is not an essential gene; protein abundance increases in response to DNA replication stress	ER-associated protein catabolic process	molecular_function	cytoplasm
YNR002C	YNR002C	ATO2	hom	Verified	0.446058457964406	0.327777509764557	no	1662	0.301587921142682	1004	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION|PLASMA MEMBRANE		Putative transmembrane protein involved in export of ammonia; ammonia is a starvation signal that promotes cell death in aging colonies; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family; homolog of Y. lipolytica Gpr1p; ATO2 has a paralog, ADY2, that arose from the whole genome duplication	ammonium transport|nitrogen utilization	ammonium transmembrane transporter activity	mitochondrion|integral to membrane|plasma membrane
YEL013W	YEL013W	VAC8	hom	Verified	0.445482086450099	0.327985701264888	no	1663	0.316471022391471	1076	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS			Phosphorylated and palmitoylated vacuolar membrane protein that interacts with Atg13p, required for the cytoplasm-to-vacuole targeting (Cvt) pathway; interacts with Nvj1p to form nucleus-vacuole junctions	piecemeal microautophagy of nucleus|vacuole inheritance|CVT vesicle assembly|vacuole fusion, non-autophagic|macroautophagy|nucleus-vacuole junction assembly	protein anchor	fungal-type vacuole membrane|nucleus-vacuole junction|Myo2p-Vac17p-Vac8p transport complex
YER058W	YER058W	PET117	hom	Verified	0.44522647915342	0.328078046445148	no	1664	0.328324294086859	1105	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Protein required for assembly of cytochrome c oxidase	mitochondrial respiratory chain complex IV assembly	molecular_function	mitochondrion
YML024W	YML024W	RPS17A	hom	Verified	0.445194365403206	0.328089649165697	no	1665	0.312029869412918	1079	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Ribosomal protein 51 (rp51) of the small (40s) subunit; homologous to mammalian ribosomal protein S17, no bacterial homolog; RPS17A has a paralog, RPS17B, that arose from the whole genome duplication	cytoplasmic translation|ribosomal small subunit assembly	structural constituent of ribosome	cytosolic small ribosomal subunit
YIL023C	YIL023C	YKE4	hom	Verified	0.444595116459774	0.328306188648562	no	1666	0.299291308509015	995	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Zinc transporter; localizes to the ER; null mutant is sensitive to calcofluor white, leads to zinc accumulation in cytosol; ortholog of the mouse KE4 and member of the ZIP (ZRT, IRT-like Protein) family	zinc ion transport	zinc ion transmembrane transporter activity	integral to membrane|endoplasmic reticulum
YFR053C	YFR053C	HXK1	hom	Verified	0.444122510744795	0.328477006115065	no	1667	0.348687856279998	1172	NA	FT	CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Hexokinase isoenzyme 1; a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves hexokinase Hxk2p; HXK1 has a paralog, HXK2, that arose from the whole genome duplication	mannose metabolic process|glucose import|glycolysis|fructose import|glucose metabolic process|fructose metabolic process	hexokinase activity	cytosol|mitochondrion|cytoplasm
YDL170W	YDL170W	UGA3	hom	Verified	0.443975428925796	0.328530174329568	no	1668	0.324114536366692	1078	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Transcriptional activator necessary for gamma-aminobutyrate (GABA)-dependent induction of GABA genes (such as UGA1, UGA2, UGA4); zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type; localized to the nucleus	nitrogen utilization|nitrogen catabolite activation of transcription from RNA polymerase II promoter|gamma-aminobutyric acid catabolic process	sequence-specific DNA binding transcription factor recruiting transcription factor activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YML112W	YML112W	CTK3	hom	Verified	0.443445103137521	0.328721909206765	no	1669	0.37177336049181	1229	NA	FF|FT	RNA PROCESSING|RESPONSE TO DNA DAMAGE|TRANSLATION|PROTEIN PHOSPHORYLATION	NUCLEUS		Gamma subunit of C-terminal domain kinase I; CTDK-I phosphorylates RNA polymerase II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and also phosphorylates ribosomal protein Rps2p to increase translational fidelity; protein abundance increases in response to DNA replication stress	mRNA 3'-end processing|positive regulation of translational fidelity|positive regulation of transcription from RNA polymerase I promoter|positive regulation of DNA-dependent transcription, elongation|protein phosphorylation	cyclin-dependent protein kinase activity	nucleoplasm|nucleolus|carboxy-terminal domain protein kinase complex
YMR262W_p	YMR262W	YMR262W	hom	Uncharacterized	0.443164800566003	0.328823268489167	no	1670	0.320982457112013	1112	NA					Protein of unknown function; interacts weakly with Knr4p; YMR262W is not an essential gene	biological_process	molecular_function	cellular_component
YML115C	YML115C	VAN1	hom	Verified	0.443015477476084	0.328877269857055	no	1671	0.383074705595552	1267	NA	FT	CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Component of the mannan polymerase I, which contains Van1p and Mnn9p and is involved in the first steps of mannan synthesis; mutants are vanadate-resistant	protein N-linked glycosylation	alpha-1,6-mannosyltransferase activity	alpha-1,6-mannosyltransferase complex
YMR280C	YMR280C	CAT8	hom	Verified	0.442898968261378	0.328919406859886	no	1672	0.289025589126149	1017	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Zinc cluster transcriptional activator; necessary for derepression of a variety of genes under non-fermentative growth conditions, active after diauxic shift, binds carbon source responsive elements; relative distribution to the nucleus increases upon DNA replication stress	positive regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source|positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter|positive regulation of glyoxylate cycle by positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YJR070C	YJR070C	LIA1	hom	Verified	0.441993199048876	0.329247063657581	no	1673	0.335745327211239	1121	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|CYTOSKELETON ORGANIZATION	NUCLEUS		Deoxyhypusine hydroxylase; HEAT-repeat containing metalloenzyme that catalyzes hypusine formation; binds to and is required for the modification of Hyp2p (eIF5A); complements S. pombe mmd1 mutants defective in mitochondrial positioning; protein abundance increases in response to DNA replication stress	microtubule cytoskeleton organization|peptidyl-lysine modification to hypusine	deoxyhypusine monooxygenase activity	nucleus|cytoplasm
YLR017W	YLR017W	MEU1	hom	Verified	0.441482497442803	0.329431864879861	no	1674	0.310672973087291	1045	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Methylthioadenosine phosphorylase (MTAP), catalyzes the initial step in the methionine salvage pathway; affects polyamine biosynthesis through regulation of ornithine decarboxylase (Spe1p) activity; regulates ADH2 gene expression	L-methionine salvage from methylthioadenosine|glutamate biosynthetic process	S-methyl-5-thioadenosine phosphorylase activity|mRNA binding	cytoplasm
YNL051W	YNL051W	COG5	hom	Verified	0.43984255914264	0.330025570461593	no	1675	0.380721994430743	1267	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments	intra-Golgi vesicle-mediated transport|CVT pathway	molecular_function	Golgi transport complex
YLR334C_d	YLR334C	YLR334C	hom	Dubious	0.438972068410021	0.330340887675606	no	1676	0.305991193887324	1032	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps a stand-alone long terminal repeat sequence whose presence indicates a retrotransposition event occurred here	Unknown	Unknown	Unknown
YDR008C_d	YDR008C	YDR008C	hom	Dubious	0.438276483717335	0.330592935437042	no	1677	0.427494868895282	1419	NA	FF				Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YKL033W-A_p	YKL033W-A	YKL033W-A	hom	Uncharacterized	0.437494000826562	0.33087656293798	no	1678	0.376814529084583	1248	NA					Putative protein of unknown function; similar to uncharacterized proteins from other fungi	biological_process	molecular_function	cellular_component
YPR152C	YPR152C	URN1	hom	Verified	0.437380135634482	0.330917843886354	no	1679	0.327361841924278	1100	NA	FT	RNA PROCESSING	NUCLEUS		Putative protein of unknown function containing WW and FF domains; overexpression causes accumulation of cells in G1 phase	biological_process	molecular_function	nucleus
YFR032C-B_p	YFR032C-B	YFR032C-B	hom	Uncharacterized	0.437350768574801	0.33092849102117	no	1680	0.315030045297841	1082	NA					Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching	biological_process	molecular_function	cellular_component
YLR300W	YLR300W	EXG1	hom	Verified	0.436779830266885	0.331135513955184	no	1681	0.315444768904187	1047	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM			Major exo-1,3-beta-glucanase of the cell wall, involved in cell wall beta-glucan assembly; exists as three differentially glycosylated isoenzymes	fungal-type cell wall organization|cellular glucan metabolic process	glucan exo-1,3-beta-glucosidase activity	extracellular region|fungal-type cell wall
YOL039W	YOL039W	RPP2A	hom	Verified	0.436063519021334	0.331395322315474	no	1682	0.343879667837122	1167	NA	FT	TRANSLATION		RIBOSOME	Ribosomal protein P2 alpha, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm	translational elongation|cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YDR502C	YDR502C	SAM2	hom	Verified	0.434508798062754	0.331959503656187	no	1683	0.313643440209378	1048	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM			S-adenosylmethionine synthetase; catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; SAM2 has a paralog, SAM1, that arose from the whole genome duplication	methionine metabolic process|S-adenosylmethionine biosynthetic process	methionine adenosyltransferase activity	cellular_component
YDR446W	YDR446W	ECM11	hom	Verified	0.433368575671664	0.332373513037238	no	1684	0.299280463032369	990	NA	FT	CELL CYCLE|CELL WALL ORG/BIOGENESIS	NUCLEUS		Non-essential protein apparently involved in meiosis, GFP fusion protein is present in discrete clusters in the nucleus throughout mitosis; may be involved in maintaining chromatin structure	fungal-type cell wall organization|reciprocal meiotic recombination	molecular_function	nucleus
YKL031W_d	YKL031W	YKL031W	hom	Dubious	0.431481448411476	0.333059169441765	no	1685	0.337283841637071	1086	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species	Unknown	Unknown	Unknown
YOR028C	YOR028C	CIN5	hom	Verified	0.430696239860814	0.333344626612311	no	1686	0.307431671705137	994	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Basic leucine zipper (bZIP) transcription factor of the yAP-1 family; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; mediates pleiotropic drug resistance and salt tolerance; nuclearly localized under oxidative stress and sequestered in the cytoplasm by Lot6p under reducing conditions; CIN5 has a paralog, YAP6, that arose from the whole genome duplication	hyperosmotic salinity response|response to drug|hyperosmotic response|regulation of transcription from RNA polymerase II promoter	repressing transcription factor binding|sequence-specific DNA binding	nucleus|cytoplasm
YNL215W	YNL215W	IES2	hom	Verified	0.427298561481482	0.334580940224257	no	1687	0.344627654417557	1133	NA	FT		NUCLEUS		Protein that associates with the INO80 chromatin remodeling complex; associates with the INO80 complex under low-salt conditions; essential for growth under anaerobic conditions; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	nucleus
YBR299W	YBR299W	MAL32	hom	Verified	0.42566128830672	0.335177337044286	no	1688	0.336648189672525	1141	NA	FT	CARBOHYDRATE METABOLISM			Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL3 complex locus; functional in genomic reference strain S288C; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose	sucrose catabolic process|maltose catabolic process	sucrose alpha-glucosidase activity|alpha-glucosidase activity|maltose alpha-glucosidase activity	plasma membrane
YLL058W_p	YLL058W	YLL058W	hom	Uncharacterized	0.423927569029589	0.335809318759332	no	1689	0.329728514201723	1118	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Putative protein of unknown function with similarity to Str2p, which is a cystathionine gamma-synthase important in sulfur metabolism; YLL058W is not an essential gene	sulfur compound metabolic process	cystathionine gamma-synthase activity	cellular_component
YNL315C	YNL315C	ATP11	hom	Verified	0.423722342490851	0.335884159478055	no	1690	0.34139548105397	1148	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Molecular chaperone, required for the assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase	mitochondrion organization|mitochondrial proton-transporting ATP synthase complex assembly	unfolded protein binding	mitochondrion|mitochondrial matrix
YHL032C	YHL032C	GUT1	hom	Verified	0.423349849524115	0.336020014486972	no	1691	0.318652568035092	1105	NA	FT	CARBOHYDRATE METABOLISM	MITOCHONDRION		Glycerol kinase, converts glycerol to glycerol-3-phosphate; glucose repression of expression is mediated by Adr1p and Ino2p-Ino4p; derepression of expression on non-fermentable carbon sources is mediated by Opi1p and Rsf1p	glycerol metabolic process	glycerol kinase activity	mitochondrion|cytoplasm
YCR069W	YCR069W	CPR4	hom	Verified	0.423046415755815	0.336130698177029	no	1692	0.317232708369739	1085	NA					Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; has a potential role in the secretory pathway	biological_process	peptidyl-prolyl cis-trans isomerase activity	membrane
YJR139C	YJR139C	HOM6	hom	Verified	0.422838578655607	0.336206519221688	no	1693	0.349610331241405	1191	NA	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS	NUCLEUS		Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase), dimeric enzyme that catalyzes the third step in the common pathway for methionine and threonine biosynthesis; enzyme has nucleotide-binding, dimerization and catalytic regions	threonine biosynthetic process|methionine biosynthetic process|homoserine biosynthetic process	homoserine dehydrogenase activity	nucleus|cytoplasm
YNL141W	YNL141W	AAH1	hom	Verified	0.42281781331945	0.336214094989372	no	1694	0.340047279884685	1147	NA	FT	NUCLEOTIDE METABOLISM	NUCLEUS		Adenine deaminase (adenine aminohydrolase), converts adenine to hypoxanthine; involved in purine salvage; transcriptionally regulated by nutrient levels and growth phase; Aah1p degraded upon entry into quiescence via SCF and the proteasome	adenine catabolic process|hypoxanthine salvage|purine-containing compound salvage	adenine deaminase activity	nucleus|cytoplasm
YDL157C_p	YDL157C	YDL157C	hom	Uncharacterized	0.421491633113302	0.336698059783657	no	1695	0.297458301027537	981	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YMR219W	YMR219W	ESC1	hom	Verified	0.420185140749296	0.337175104472899	no	1696	0.352732053839575	1201	NA	FT	GENE SILENCING	NUCLEUS		Protein localized to the nuclear periphery, involved in telomeric silencing; interacts with PAD4-domain of Sir4p	chromatin silencing at telomere	molecular_function	nuclear periphery
YBL093C	YBL093C	ROX3	hom	Verified	0.419995215346082	0.337244474505483	no	1697	0.353540625843629	1175	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS	RNA POL II, HOLOENZYME	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme	negative regulation of transcription from RNA polymerase II promoter|transcriptional open complex formation at RNA polymerase II promoter|RNA polymerase II transcriptional preinitiation complex assembly|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II transcription factor recruiting transcription factor activity	core mediator complex|nucleus
YDR430C	YDR430C	CYM1	hom	Verified	0.419797397477039	0.337316733135426	no	1698	0.31680468736974	1041	NA	FT	PROTEOLYSIS	MITOCHONDRION		Lysine-specific metalloprotease of the mitochondrial intermembrane space, member of the pitrilysin family; degrades proteins and presequence peptides cleaved from imported proteins; required for normal mitochondrial morphology	proteolysis|proteolysis involved in cellular protein catabolic process	metalloendopeptidase activity	mitochondrion|mitochondrial intermembrane space
YHL026C_p	YHL026C	YHL026C	hom	Uncharacterized	0.419664445524345	0.337365301007699	no	1699	0.346634497240835	1157	NA					Putative protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; YHL026C is not an essential gene; in 2005 the start site was moved 141 nt upstream (see Locus History)	biological_process	molecular_function	cellular_component
YBR046C	YBR046C	ZTA1	hom	Verified	0.419151917835836	0.33755255474522	no	1700	0.34280085846179	1150	NA	FT	OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		NADPH-dependent quinone reductase, GFP-tagged protein localizes to the cytoplasm and nucleus; has similarity to E. coli quinone oxidoreductase and to human zeta-crystallin	cellular response to oxidative stress	NADPH:quinone reductase activity|AU-rich element binding|2-alkenal reductase [NAD(P)] activity	nucleus|cytoplasm
YOL058W	YOL058W	ARG1	hom	Verified	0.418994604527888	0.337610037769578	no	1701	0.353134456603401	1170	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Arginosuccinate synthetase, catalyzes the formation of L-argininosuccinate from citrulline and L-aspartate in the arginine biosynthesis pathway; potential Cdc28p substrate	argininosuccinate metabolic process|arginine biosynthetic process|citrulline metabolic process	argininosuccinate synthase activity	cytosol
YGR039W_d	YGR039W	YGR039W	hom	Dubious	0.418798622662882	0.337681655767392	no	1702	0.350947188898853	1193	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the Autonomously Replicating Sequence ARS722	Unknown	Unknown	Unknown
YMR261C	YMR261C	TPS3	hom	Verified	0.41666653939669	0.338461166062531	no	1703	0.33130394530772	1111	NA	FT	CARBOHYDRATE METABOLISM			Regulatory subunit of trehalose-6-phosphate synthase/phosphatase; involved in synthesis of storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway; TPS3 has a paralog, TSL1, that arose from the whole genome duplication	trehalose biosynthetic process|response to stress	enzyme regulator activity|alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity|trehalose-phosphatase activity	alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)
YLR416C_d	YLR416C	YLR416C	hom	Dubious	0.4162155779891	0.338626130784897	no	1704	0.331015373477992	1087	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YJR038C_d	YJR038C	YJR038C	hom	Dubious	0.416053038820231	0.338685596301788	no	1705	0.333177187682582	1134	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YML100W	YML100W	TSL1	hom	Verified	0.416036793222929	0.338691540030807	no	1706	0.309340376562542	1043	NA	FT	CARBOHYDRATE METABOLISM			Large subunit of trehalose 6-phosphate synthase/phosphatase complex; Tps1p-Tps2p complex converts uridine-5'-diphosphoglucose and glucose 6-phosphate to trehalose; mutant has aneuploidy tolerance; protein abundance increases in response to DNA replication stress; TSL1 has a paralog, TPS3, that arose from the whole genome duplication	trehalose biosynthetic process|response to stress	enzyme regulator activity|alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity|trehalose-phosphatase activity	alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)
YGL220W	YGL220W	FRA2	hom	Verified	0.415685961630853	0.338819907555153	no	1707	0.333751255707235	1129	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Protein involved in negative regulation of transcription of iron regulon; forms an iron independent complex with Fra2p, Grx3p, and Grx4p; null mutant fails to repress iron regulon and is sensitive to nickel	negative regulation of transcription from RNA polymerase II promoter in response to iron	molecular_function	cytosol|nucleus|cytoplasm
YBR185C	YBR185C	MBA1	hom	Verified	0.412670638152708	0.33992396991863	no	1708	0.347379589532252	1162	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Membrane-associated mitochondrial ribosome receptor; forms a complex with Mdm38p that may facilitate recruitment of mRNA-specific translational activators to ribosomes; possible role in protein export from the matrix to inner membrane	protein insertion into mitochondrial membrane from inner side|mitochondrial respiratory chain complex III biogenesis|inner mitochondrial membrane organization|positive regulation of mitochondrial translation|mitochondrial respiratory chain complex IV biogenesis	ribosome binding	mitochondrion|mitochondrial inner membrane
YJL102W	YJL102W	MEF2	hom	Verified	0.412255120621211	0.340076219849804	no	1709	0.352190525853268	1178	NA	FT	TRANSLATION|NUCLEOTIDE METABOLISM	MITOCHONDRION		Mitochondrial elongation factor involved in translational elongation	translational elongation	translation elongation factor activity	mitochondrion
YOR211C	YOR211C	MGM1	hom	Verified	0.412240510576946	0.340081573596279	no	1710	0.334360976027851	1116	NA	FT	MEMBRANE ORGANIZATION|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial GTPase, present in complex with Ugo1p and Fzo1p; required for mt morphology and genome maintenance; exists as long and short form with different distributions; homolog of human OPA1 involved in autosomal dominant optic atrophy	mitochondrion organization|mitochondrial genome maintenance|mitochondrial fusion	GTPase activity	intrinsic to mitochondrial inner membrane|extrinsic to mitochondrial inner membrane|mitochondrion|mitochondrial inner boundary membrane|mitochondrial crista|mitochondrial intermembrane space
YKL063C_p	YKL063C	YKL063C	hom	Uncharacterized	0.411308456400168	0.340423184802576	no	1711	0.319879082138738	1076	NA	FT		GOLGI APPARATUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi	biological_process	molecular_function	Golgi apparatus
YCR089W	YCR089W	FIG2	hom	Verified	0.410677397874538	0.340654551171958	no	1712	0.328181485127096	1074	NA	FT	CELL WALL ORG/BIOGENESIS			Cell wall adhesin, expressed specifically during mating; may be involved in maintenance of cell wall integrity during mating	filamentous growth of a population of unicellular organisms|cell morphogenesis involved in conjugation with cellular fusion|invasive growth in response to glucose limitation|cytogamy	molecular_function	fungal-type cell wall|mating projection
YDR337W	YDR337W	MRPS28	hom	Verified	0.410040497831249	0.340888120033773	no	1713	0.358435593568638	1175	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the small subunit	mitochondrial translation	structural constituent of ribosome|RNA binding	mitochondrion|mitochondrial small ribosomal subunit
YNL233W	YNL233W	BNI4	hom	Verified	0.409727756545913	0.341002833250811	no	1714	0.378850913675463	1256	NA	FT	PROTEIN LOCALIZATION|CELL DIVISION|CARBOHYDRATE METABOLISM	SITE OF POLARIZED GROWTH|CYTOSKELETON		Targeting subunit for Glc7p protein phosphatase, localized to the bud neck, required for localization of chitin synthase III to the bud neck via interaction with the chitin synthase III regulatory subunit Skt5p	asymmetric protein localization|barrier septum assembly|chitin biosynthetic process	protein binding	incipient cellular bud site|cellular bud neck septin collar|cellular bud neck|septin ring
YAR035W	YAR035W	YAT1	hom	Verified	0.40936842643208	0.341134653354974	no	1715	0.328957585636699	1108	NA	FT	KETONE METABOLISM|LIPID METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		Outer mitochondrial carnitine acetyltransferase, minor ethanol-inducible enzyme involved in transport of activated acyl groups from the cytoplasm into the mitochondrial matrix; phosphorylated	carnitine metabolic process|alcohol metabolic process	carnitine O-acetyltransferase activity	mitochondrion
YMR140W	YMR140W	SIP5	hom	Verified	0.408436167194	0.341476742657311	no	1716	0.324344632802631	1084	NA	FT	RESPONSE TO NUTRIENT LEVELS			Protein of unknown function; interacts with both the Reg1p/Glc7p phosphatase and the Snf1p kinase; forms cytoplasmic foci upon DNA replication stress	cellular response to glucose starvation	molecular_function	cytoplasm
YMR009W	YMR009W	ADI1	hom	Verified	0.407159866291987	0.341945288080602	no	1717	0.328428312655213	1091	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS	NUCLEUS		Acireductone dioxygenease involved in the methionine salvage pathway; ortholog of human MTCBP-1; transcribed as polycistronic mRNA with YMR010W and regulated post-transcriptionally by RNase III (Rnt1p) cleavage; ADI1 mRNA is induced in heat shock conditions	L-methionine salvage from methylthioadenosine	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	nucleus|cytoplasm
YBR279W	YBR279W	PAF1	hom	Verified	0.40673266918096	0.342102171715741	no	1718	0.427113845013395	1419	NA	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|RIBOSOME BIOGENESIS|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION|GENE SILENCING	NUCLEUS|CHROMOSOME	RNA POL II, HOLOENZYME	Component of the Paf1p complex involved in transcription elongation; binds to and modulates the activity of RNA polymerases I and II; required for expression of a subset of genes, including cell cycle-regulated genes; involved in SER3 repression by helping to maintain SRG1 transcription-dependent nucleosome occupancy; homolog of human PD2/hPAF1	negative regulation of DNA recombination|mRNA 3'-end processing|snoRNA transcription from an RNA polymerase II promoter|regulation of transcription by chromatin organization|transcription from RNA polymerase I promoter|regulation of transcription-coupled nucleotide-excision repair|rRNA processing|transcription elongation from RNA polymerase I promoter|regulation of chromatin silencing at telomere|regulation of transcription from RNA polymerase II promoter|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of histone H3-K4 methylation|negative regulation of transcription from RNA polymerase II promoter|global genome nucleotide-excision repair|chromatin silencing at rDNA|Unknown|snoRNA 3'-end processing|transcription elongation from RNA polymerase II promoter|regulation of transcription involved in G1 phase of mitotic cell cycle	RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity|chromatin binding|TFIIF-class binding transcription factor activity|RNA polymerase II core binding|RNA polymerase II transcription factor binding transcription factor activity	transcriptionally active chromatin|nucleus|Cdc73/Paf1 complex
YLR219W	YLR219W	MSC3	hom	Verified	0.406442095626137	0.34220889736959	no	1719	0.30903132555461	1052	NA	FT	CELL CYCLE	PLASMA MEMBRANE		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; msc3 mutants are defective in directing meiotic recombination events to homologous chromatids; potential Cdc28p substrate; protein abundance increases in response to DNA replication stress	reciprocal meiotic recombination	molecular_function	cellular_component
YBR009C	YBR009C	HHF1	hom	Verified	0.405839040658958	0.342430435500302	no	1720	0.300485722194456	1010	NA	FT	CHROMATIN ORGANIZATION	NUCLEUS|CHROMOSOME		Histone H4, core histone protein required for chromatin assembly and chromosome function; one of two identical histone proteins (see also HHF2); contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity	chromatin assembly or disassembly|sexual sporulation resulting in formation of a cellular spore|histone H3-K79 methylation	DNA binding	replication fork protection complex|nuclear nucleosome
YKR007W	YKR007W	MEH1	hom	Verified	0.404858611696396	0.342790721367063	no	1721	0.351196723144927	1171	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS			Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; loss results in a defect in vacuolar acidification	microautophagy|vacuolar acidification	molecular_function	fungal-type vacuole membrane|EGO complex|late endosome membrane
YCL076W_d	YCL076W	YCL076W	hom	Dubious	0.404676379293603	0.342857703500174	no	1722	0.31698916300693	1080	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YNL147W	YNL147W	LSM7	hom	Verified	0.404290164531817	0.342999678600924	no	1723	0.326116331822991	1092	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress	nuclear-transcribed mRNA catabolic process|mRNA splicing, via spliceosome|maturation of SSU-rRNA	RNA binding	U6 snRNP|nucleolus|small nucleolar ribonucleoprotein complex|U4/U6 x U5 tri-snRNP complex|cytoplasm
YOR284W	YOR284W	HUA2	hom	Verified	0.403804221352333	0.343178346021838	no	1724	0.342096912275014	1136	NA					Cytoplasmic protein of unknown function; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin patch assembly	biological_process	molecular_function	cytoplasm
YGL115W	YGL115W	SNF4	hom	Verified	0.403525808424485	0.343280726300778	no	1725	0.343854006230263	1137	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION|PEROXISOME ORGANIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS|PLASMA MEMBRANE		Activating gamma subunit of the AMP-activated Snf1p kinase complex; additional subunits of the complex are Snf1p and a Sip1p/Sip2p/Gal83p family member; activates glucose-repressed genes, represses glucose-induced genes; role in sporulation, and peroxisome biogenesis; protein abundance increases in response to DNA replication stress	positive regulation of gluconeogenesis|peroxisome organization|protein phosphorylation|replicative cell aging|regulation of transcription from RNA polymerase II promoter	AMP-activated protein kinase activity|protein serine/threonine kinase activator activity	AMP-activated protein kinase complex|plasma membrane|nucleus|nuclear envelope lumen|cytoplasm
YBR260C	YBR260C	RGD1	hom	Verified	0.402690893629923	0.343587816940787	no	1726	0.329013030326362	1085	NA	FT	SIGNALING	SITE OF POLARIZED GROWTH|CYTOSKELETON		GTPase-activating protein (RhoGAP) for Rho3p and Rho4p, possibly involved in control of actin cytoskeleton organization	response to acid|osmosensory signaling pathway	Rho GTPase activator activity|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4-phosphate binding|phosphatidylinositol-5-phosphate binding	cellular bud|mating projection tip|actin cortical patch
YOR051C	YOR051C	ETT1	hom	Verified	0.402517523479035	0.34365159730045	no	1727	0.322308369291832	1078	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION	NUCLEUS		Nuclear protein that inhibits replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts; deletion increases stop codon readthrough	translational termination	molecular_function	nucleus
YDL115C	YDL115C	IWR1	hom	Verified	0.402221939087334	0.343760348766305	no	1728	0.347360682253094	1183	NA	FT	PROTEIN LOCALIZATION	NUCLEUS	RNA POL II, HOLOENZYME	RNA polymerase II transport factor, conserved from yeast to humans; also has a role in transporting RNA polymerase III into the nucleus; interacts with most of the RNAP II subunits; nucleo-cytoplasmic shuttling protein; deletion causes hypersensitivity to K1 killer toxin; protein increases in abundance and relocalizes from nucleus to cytoplasm upon DNA replication stress	cellular protein complex localization|nucleocytoplasmic transport	protein binding	nucleus|DNA-directed RNA polymerase II, holoenzyme|cytoplasm
YLR254C	YLR254C	NDL1	hom	Verified	0.402053736045254	0.343822239834741	no	1729	0.339740184126884	1144	NA	FT	CELL CYCLE|CELL DIVISION	NUCLEUS|CYTOSKELETON		Homolog of nuclear distribution factor NudE, NUDEL; interacts with Pac1p and regulates dynein targeting to microtubule plus ends	nuclear migration along microtubule	microtubule plus-end binding	cytoplasmic microtubule|nucleus|cytoplasm
YGR160W_d	YGR160W	YGR160W	hom	Dubious	0.401030716955069	0.344198754416834	no	1730	0.321018989823663	1107	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YHL028W	YHL028W	WSC4	hom	Verified	0.400858574438649	0.344262125387387	no	1731	0.332880521617095	1107	NA	FT	PROTEIN LOCALIZATION|CELL WALL ORG/BIOGENESIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		ER membrane protein involved in the translocation of soluble secretory proteins and insertion of membrane proteins into the ER membrane; may also have a role in the stress response but has only partial functional overlap with WSC1-3	response to heat|SRP-dependent cotranslational protein targeting to membrane, translocation|protein targeting to ER|response to stress	transmembrane signaling receptor activity	endoplasmic reticulum membrane
YDL171C	YDL171C	GLT1	hom	Verified	0.400196209635035	0.344506003075791	no	1732	0.329194676410154	1137	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS	MITOCHONDRION		NAD(+)-dependent glutamate synthase (GOGAT), synthesizes glutamate from glutamine and alpha-ketoglutarate; with Gln1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source	glutamate biosynthetic process|ammonia assimilation cycle	glutamate synthase (NADH) activity	mitochondrion
YHR210C_p	YHR210C	YHR210C	hom	Uncharacterized	0.39949887990827	0.344762824445775	no	1733	0.346873223136911	1171	NA	FT	CARBOHYDRATE METABOLISM			Putative aldose 1-epimerase superfamily protein; non-essential gene; highly expressed under anaeorbic conditions	biological_process	molecular_function	cellular_component
YBR045C	YBR045C	GIP1	hom	Verified	0.3968881391405	0.345724975511611	no	1734	0.355715189110724	1183	NA	FT	CELL WALL ORG/BIOGENESIS			Meiosis-specific regulatory subunit of the Glc7p protein phosphatase, regulates spore wall formation and septin organization, required for expression of some late meiotic genes and for normal localization of Glc7p	ascospore wall assembly|regulation of phosphoprotein phosphatase activity	protein phosphatase type 1 regulator activity|protein phosphatase 1 binding	protein phosphatase type 1 complex|prospore membrane
YIL079C	YIL079C	AIR1	hom	Verified	0.395568181332563	0.346211807017541	no	1735	0.34466102486513	1153	NA	FT	RNA PROCESSING	NUCLEUS		Zinc knuckle protein; involved in nuclear RNA processing and degradation as a component of the TRAMP complex; stimulates the poly(A) polymerase activity of Pap2p in vitro; AIR1 has a paralog, AIR2, that arose from the whole genome duplication	nuclear mRNA surveillance of mRNA 3'-end processing|nuclear polyadenylation-dependent tRNA catabolic process|nuclear polyadenylation-dependent CUT catabolic process|nuclear polyadenylation-dependent snoRNA catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|ncRNA polyadenylation|nuclear polyadenylation-dependent snRNA catabolic process	polynucleotide adenylyltransferase activity	nucleolus|TRAMP complex
YHL030W	YHL030W	ECM29	hom	Verified	0.393350285456891	0.34703039138892	no	1736	0.33912056874408	1141	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS	NUCLEUS		Scaffold protein; assists in association of the proteasome core particle with the regulatory particle; degraded by the mature proteasome after assembly; contains HEAT-like repeats; protein increases in abundance and relocalizes from nucleus to cytoplasm upon DNA replication stress	proteasome assembly	protein complex scaffold	proteasome complex|nucleus|cytoplasm
YKL096W-A	YKL096W-A	CWP2	hom	Verified	0.393183730869631	0.347091892491517	no	1737	0.348530431373978	1173	NA	FT	ION HOMEOSTASIS|CELL WALL ORG/BIOGENESIS|ION HOMEOSTASIS			Covalently linked cell wall mannoprotein, major constituent of the cell wall; plays a role in stabilizing the cell wall; involved in low pH resistance; precursor is GPI-anchored	fungal-type cell wall organization|regulation of pH	structural constituent of cell wall	fungal-type cell wall
YMR158W-B_d	YMR158W-B	YMR158W-B	hom	Dubious	0.392394296644352	0.347383449733959	no	1738	0.328526961531412	1114	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene ATG16/YMR159C	Unknown	Unknown	Unknown
YCR028C-A	YCR028C-A	RIM1	hom	Verified	0.392302761757354	0.347417261638999	no	1739	0.378644319953626	1259	NA	FT	MITOCHONDRION ORGANIZATION	MITOCHONDRION		Single-stranded DNA-binding protein essential for mitochondrial genome maintenance; involved in mitochondrial DNA replication	mitochondrial DNA replication|mitochondrial genome maintenance	single-stranded DNA binding	mitochondrial nucleoid|mitochondrion
YIL139C	YIL139C	REV7	hom	Verified	0.392006492398705	0.347526708361013	no	1740	0.331763421780706	1097	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS|MITOCHONDRION|CHROMOSOME		Accessory subunit of DNA polymerase zeta, involved in translesion synthesis during post-replication repair; required for mutagenesis induced by DNA damage; involved in double-strand break repair	error-prone translesion synthesis|error-free translesion synthesis	DNA-directed DNA polymerase activity	nuclear chromatin|mitochondrion|zeta DNA polymerase complex
YMR132C_p	YMR132C	JLP2	hom	Uncharacterized	0.390599684300004	0.348046579515422	no	1741	0.329725023638682	1096	NA					Protein of unknown function, contains sequence that closely resembles a J domain (typified by the E. coli DnaJ protein)	biological_process	molecular_function	cytoplasm
YNL187W	YNL187W	SWT21	hom	Verified	0.389702019910912	0.348378451352523	no	1742	0.344790289076703	1167	NA	FT	RNA PROCESSING	NUCLEUS		Protein involved in mRNA splicing; contains a consensus nuclear export signal (NES) sequence similar to the consensus sequence recognized by Crm1p; interacts genetically with Prp40p and Tgs1p; contains WD40 repeats	mRNA splicing, via spliceosome	molecular_function	small nuclear ribonucleoprotein complex|nucleus
YDR500C	YDR500C	RPL37B	hom	Verified	0.389407188045169	0.34848747778103	no	1743	0.313964381257376	1054	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L37B; protein abundance increases in response to DNA replication stress; homologous to mammalian ribosomal protein L37, no bacterial homolog; RPL37B has a paralog, RPL37A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YDR414C	YDR414C	ERD1	hom	Verified	0.389385535980897	0.348495485031986	no	1744	0.363302291428969	1219	NA	FT	PROTEIN LOCALIZATION|CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Predicted membrane protein required for the retention of lumenal endoplasmic reticulum proteins; mutants secrete the endogenous ER protein, BiP (Kar2p)	protein retention in ER lumen|protein glycosylation	molecular_function	integral to membrane|membrane
YAL059W	YAL059W	ECM1	hom	Verified	0.387368408804459	0.349241743919895	no	1745	0.316216454165391	1054	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|CELL WALL ORG/BIOGENESIS	NUCLEUS		Pre-ribosomal factor involved in 60S ribosomal protein subunit export; associates with the pre-60S particle; shuttles between the nucleus and cytoplasm	fungal-type cell wall organization|ribosomal large subunit export from nucleus	molecular_function	nucleolus|nucleus|preribosome, large subunit precursor
YDR073W	YDR073W	SNF11	hom	Verified	0.3871715916304	0.349314589924446	no	1746	0.332074947985222	1109	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS	RSC COMPLEX	Subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; interacts with a highly conserved 40-residue sequence of Snf2p; relocates to the cytosol under hypoxic conditions	positive regulation of transcription from RNA polymerase II promoter	molecular_function	SWI/SNF complex
YLR224W_p	YLR224W	YLR224W	hom	Uncharacterized	0.386267962719095	0.349649112418667	no	1747	0.336197327505999	1135	NA	FT	PROTEOLYSIS			F-box protein and component of SCF ubiquitin ligase complexes involved in ubiquitin-dependent protein catabolism; readily monoubiquitinated in vitro by SCF-Ubc4 complexes; YLR224W is not an essential gene	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|cellular response to methylmercury	ubiquitin-protein ligase activity|protein binding, bridging	SCF ubiquitin ligase complex
YMR104C	YMR104C	YPK2	hom	Verified	0.386158405272336	0.349689678415296	no	1748	0.312744872907007	1049	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL WALL ORG/BIOGENESIS|PROTEIN PHOSPHORYLATION	NUCLEUS		Protein kinase with similarity to serine/threonine protein kinase Ypk1p; functionally redundant with YPK1 at the genetic level; participates in a signaling pathway required for optimal cell wall integrity; homolog of mammalian kinase SGK; YPK2 has a paralog, YPK1, that arose from the whole genome duplication	eisosome assembly|protein phosphorylation	protein kinase activity	nucleus|cytoplasm
YOL164W	YOL164W	BDS1	hom	Verified	0.386042099978308	0.349732744825288	no	1749	0.363354536999046	1181	NA					Bacterially-derived sulfatase required for use of alkyl- and aryl-sulfates as sulfur sources	dodecyl sulfate metabolic process	arylsulfatase activity|alkyl sulfatase activity	cellular_component
YNL250W	YNL250W	RAD50	hom	Verified	0.385731324458223	0.349847830636806	no	1750	0.272404892330886	951	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS|MITOCHONDRION		Subunit of MRX complex with Mre11p and Xrs2p; complex is involved in processing double-strand DNA breaks in vegetative cells, initiation of meiotic DSBs, telomere maintenance, and nonhomologous end joining; forms nuclear foci upon DNA replication stress	base-excision repair|meiotic DNA double-strand break processing|telomere maintenance via recombination|meiosis|meiotic DNA double-strand break formation|double-strand break repair via nonhomologous end joining|telomere maintenance|double-strand break repair via break-induced replication|negative regulation of endodeoxyribonuclease activity	double-stranded DNA binding|single-stranded telomeric DNA binding|ATPase activity|double-stranded telomeric DNA binding|G-quadruplex DNA binding|telomeric DNA binding|adenylate kinase activity	mitochondrion|nucleus|Mre11 complex
YKR106W	YKR106W	GEX2	hom	Verified	0.385068696796535	0.350093259735862	no	1751	0.336257149821804	1121	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Proton:glutathione antiporter localized to the vacuolar and plasma membranes; expressed at a very low level; almost identical to paralog Gex1p; potential role in resistance to oxidative stress and modulation of the PKA pathway	glutathione transmembrane transport	solute:hydrogen antiporter activity	integral to membrane|plasma membrane|vacuolar membrane
YLR111W_d	YLR111W	YLR111W	hom	Dubious	0.384612607656251	0.350262225914602	no	1752	0.366618567254892	1236	NA	FF				Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YIL077C_p	YIL077C	YIL077C	hom	Uncharacterized	0.38227059465405	0.351130331749645	no	1753	0.366043622118217	1218	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)	biological_process	molecular_function	mitochondrion
YDL131W	YDL131W	LYS21	hom	Verified	0.380438644684822	0.351809916472418	no	1754	0.328306797936442	1123	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS|MITOCHONDRION		Homocitrate synthase isozyme; catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; LYS21 has a paralog, LYS20, that arose from the whole genome duplication	lysine biosynthetic process via aminoadipic acid	homocitrate synthase activity	nucleus
YPL181W	YPL181W	CTI6	hom	Verified	0.380399122612397	0.351824582906905	no	1755	0.355266902211498	1188	NA	FT	CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS|CHROMOSOME		Protein that relieves transcriptional repression by binding to the Cyc8p-Tup1p corepressor and recruiting the SAGA complex to the repressed promoter; contains a PHD finger domain	negative regulation of chromatin silencing at silent mating-type cassette|positive regulation of transcription, DNA-dependent|regulation of DNA-dependent DNA replication initiation|negative regulation of chromatin silencing at telomere|negative regulation of chromatin silencing at rDNA	methylated histone residue binding|transcription factor binding	Rpd3L-Expanded complex|nucleus|Rpd3L complex
YLR216C	YLR216C	CPR6	hom	Verified	0.379895841433854	0.352011367196735	no	1756	0.323344067312159	1061	NA					Peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity; protein abundance increases in response to DNA replication stress	protein folding|protein refolding	unfolded protein binding|peptidyl-prolyl cis-trans isomerase activity	cytoplasm
YDR186C	YDR186C	YDR186C	hom	Verified	0.379719352911585	0.352076876384555	no	1757	0.334464062024604	1127	NA					Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	biological_process	molecular_function	ribosome|cytoplasm
YPL110C	YPL110C	GDE1	hom	Verified	0.378918352578689	0.352374247650122	no	1758	0.363277380559452	1216	NA	FT	LIPID METABOLISM|SIGNALING|CARBOHYDRATE METABOLISM			Glycerophosphocholine (GroPCho) phosphodiesterase; hydrolyzes GroPCho to choline and glycerolphosphate, for use as a phosphate source and as a precursor for phosphocholine synthesis; may interact with ribosomes	glycerophospholipid catabolic process	glycerophosphocholine phosphodiesterase activity	ribosome|cytoplasm
YOR135C_d	YOR135C	IRC14	hom	Dubious	0.378702444092828	0.352454419098605	no	1759	0.331304458593623	1091	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YOR136W; null mutant displays increased levels of spontaneous Rad52 foci	Unknown	Unknown	Unknown
YER140W	YER140W	EMP65	hom	Verified	0.37835282333046	0.352584254682228	no	1760	0.347251456843629	1159	NA	FT		MITOCHONDRION		ER membrane protein of unknown function; forms an ER-membrane associated protein complex with Slp1p; identified along with SLP1 in a screen for mutants defective in the unfolded protein response (UPR); proposed to function in the folding of integral membrane proteins; interacts genetically with MPS1; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	protein folding in endoplasmic reticulum	molecular_function	mitochondrion|integral to membrane
YMR142C	YMR142C	RPL13B	hom	Verified	0.37648819330303	0.353276995658841	no	1761	0.366719907046044	1242	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L13B; not essential for viability; homologous to mammalian ribosomal protein L13, no bacterial homolog; RPL13B has a paralog, RPL13A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YBL032W	YBL032W	HEK2	hom	Verified	0.375411551229614	0.353677207719132	no	1762	0.349334801618864	1175	NA	FT	CHROMATIN ORGANIZATION|TRANSLATION|RNA LOCALIZATION	NUCLEUS|CHROMOSOME		RNA binding protein involved in the asymmetric localization of ASH1 mRNA; represses translation of ASH1 mRNA, an effect reversed by Yck1p-dependent phosphoryation; regulates telomere position effect and length; similarity to hnRNP-K	telomere maintenance via telomerase|intracellular mRNA localization|mRNA stabilization	mRNA binding	nuclear chromosome, telomeric region|cytoplasmic mRNA processing body|cytoplasm
YMR064W	YMR064W	AEP1	hom	Verified	0.375210360294361	0.353752012866102	no	1763	0.373920851177822	1245	NA	FT	TRANSLATION	MITOCHONDRION		Protein required for expression of the mitochondrial OLI1 gene encoding subunit 9 of F1-F0 ATP synthase	regulation of translation	translation regulator activity	mitochondrion
YDR161W_p	YDR161W	YDR161W	hom	Uncharacterized	0.375101209140511	0.353792598907077	no	1764	0.357777115461003	1207	NA	FT	PROTEOLYSIS	NUCLEUS		Putative protein of unknown function; non-essential gene; proposed function in rRNA and ribosome biosynthesis based on transcriptional co-regulation; genetic interactions suggest a role in ER-associated protein degradation (ERAD)	ER-associated protein catabolic process	molecular_function	nucleus|cytoplasm
YFR016C	YFR016C	YFR016C	hom	Verified	0.374075915946053	0.35417391818637	no	1765	0.325768028887254	1105	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and bud; interacts with Spa2p; YFL016C is not an essential gene	biological_process	molecular_function	cellular bud|cytoplasm
YHR059W	YHR059W	FYV4	hom	Verified	0.373251867342976	0.354480498146588	no	1766	0.339084427585799	1157	NA	FT		MITOCHONDRION		Protein of unknown function, required for survival upon exposure to K1 killer toxin	biological_process	molecular_function	mitochondrion
YML082W_p	YML082W	YML082W	hom	Uncharacterized	0.372985026491255	0.354579794137451	no	1767	0.378833952209819	1276	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Putative protein predicted to have carbon-sulfur lyase activity; transcriptionally regulated by Upc2p via an upstream sterol response element; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and the cytoplasm; YML082W is not an essential gene	sulfur compound metabolic process	carbon-sulfur lyase activity	nucleus|cytoplasm
YNR064C	YNR064C	YNR064C	hom	Verified	0.372885903896712	0.354616681848017	no	1768	0.350537825088255	1198	NA					Epoxide hydrolase, member of the alpha/beta hydrolase fold family; may have a role in detoxification of epoxides	response to toxin	epoxide hydrolase activity	cellular_component
YNL198C_d	YNL198C	YNL198C	hom	Dubious	0.371651971298064	0.355075994397467	no	1769	0.347302063065196	1145	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YAR018C	YAR018C	KIN3	hom	Verified	0.371204716218877	0.355242530319008	no	1770	0.370733504955012	1239	NA	FT	PROTEIN PHOSPHORYLATION|CHROMOSOME SEGREGATION			Nonessential serine/threonine protein kinase; possible role in DNA damage response	chromosome segregation|protein phosphorylation	protein kinase activity	cellular_component
YDR283C	YDR283C	GCN2	hom	Verified	0.370983182038787	0.355325029056904	no	1771	0.39596884125717	1301	NA	FF|FT	KETONE METABOLISM|CELL CYCLE|AMINO ACID METABOLISM|RESPONSE TO DNA DAMAGE|TRANSLATION|PROTEIN PHOSPHORYLATION		RIBOSOME	Protein kinase, phosphorylates the alpha-subunit of translation initiation factor eIF2 (Sui2p) in response to starvation; activated by uncharged tRNAs and the Gcn1p-Gcn20p complex; contributes to DNA damage checkpoint control	cellular amino acid biosynthetic process|protein phosphorylation|regulation of translational initiation|DNA damage checkpoint	protein homodimerization activity|protein kinase activity|eukaryotic translation initiation factor 2alpha kinase activity	cytosolic ribosome
YPR154W	YPR154W	PIN3	hom	Verified	0.369564365047777	0.355853553344082	no	1772	0.357595119135662	1195	NA	FT	CYTOSKELETON ORGANIZATION	NUCLEUS		Protein that induces appearance of [PIN+] prion when overproduced	actin cytoskeleton organization	molecular_function	nucleus|cytoplasm
YBR115C	YBR115C	LYS2	hom	Verified	0.368252952971344	0.356342314708062	no	1773	0.346011116581485	1140	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS			Alpha aminoadipate reductase, catalyzes the reduction of alpha-aminoadipate to alpha-aminoadipate 6-semialdehyde, which is the fifth step in biosynthesis of lysine; activation requires posttranslational phosphopantetheinylation by Lys5p	lysine biosynthetic process via aminoadipic acid	L-aminoadipate-semialdehyde dehydrogenase activity	cytoplasm
YOR173W	YOR173W	DCS2	hom	Verified	0.368185929182216	0.356367300724009	no	1774	0.351316717357441	1219	NA					Non-essential, stress induced regulatory protein; modulates m7G-oligoribonucleotide metabolism; inhibits Dcs1p; regulated by Msn2p, Msn4p, and the Ras-cAMP-cAPK signaling pathway; mutant has increased aneuploidy tolerance	deadenylation-dependent decapping of nuclear-transcribed mRNA	m7G(5')pppN diphosphatase activity	cytoplasmic mRNA processing body|cytoplasm
YOR100C	YOR100C	CRC1	hom	Verified	0.367519748410567	0.356615681922791	no	1775	0.341875350544061	1171	NA	FT	KETONE METABOLISM|LIPID METABOLISM	MITOCHONDRION		Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation	fatty acid metabolic process	carnitine:acyl carnitine antiporter activity	mitochondrion|integral to membrane|mitochondrial inner membrane
YLR322W_d	YLR322W	VPS65	hom	Dubious	0.367382539393421	0.356666846975275	no	1776	0.359364259941251	1218	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 75% of ORF overlaps the verified gene SFH1; deletion causes a vacuolar protein sorting defect and blocks anaerobic growth	Unknown	Unknown	Unknown
YIL015W	YIL015W	BAR1	hom	Verified	0.367375794381819	0.356669362247279	no	1777	0.355441474856434	1176	NA	FT	SIGNALING|PROTEOLYSIS			Aspartyl protease secreted into the periplasmic space of mating type a cells, helps cells find mating partners, cleaves and inactivates alpha factor allowing cells to recover from alpha-factor-induced cell cycle arrest	adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion|peptide catabolic process	aspartic-type endopeptidase activity	cell wall-bounded periplasmic space
YOR187W	YOR187W	TUF1	hom	Verified	0.367239525259454	0.356720179492964	no	1778	0.426936986136717	1389	NA	FT	TRANSLATION|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial translation elongation factor Tu; comprises both GTPase and guanine nucleotide exchange factor activities, while these activities are found in separate proteins in S. pombe and humans	mitochondrial translational elongation|mitochondrial translation	GTPase activity|translation elongation factor activity	mitochondrion|mitochondrial matrix
YKR093W	YKR093W	PTR2	hom	Verified	0.365127785272652	0.357508010490045	no	1779	0.375618423098187	1265	NA	FF|FT	PROTEIN LOCALIZATION	PLASMA MEMBRANE		Integral membrane peptide transporter, mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p	dipeptide transport|tripeptide transport|peptide transport	dipeptide transporter activity|tripeptide transporter activity|peptide transporter activity	integral to membrane|plasma membrane
YGL053W	YGL053W	PRM8	hom	Verified	0.365112730050507	0.357513629356712	no	1780	0.349071699172902	1177	NA	FT	VESICLE-MEDIATED TRANSPORT	ENDOPLASMIC RETICULUM|PLASMA MEMBRANE		Pheromone-regulated protein with 2 predicted transmembrane segments and an FF sequence, a motif involved in COPII binding; forms a complex with Prp9p in the ER; member of DUP240 gene family	biological_process	molecular_function	integral to membrane|endoplasmic reticulum|plasma membrane
YOR342C	YOR342C	YOR342C	hom	Verified	0.365010288039719	0.357551863289103	no	1781	0.364311303350558	1220	NA	FT		NUCLEUS		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; relocalizes from nucleus to cytoplasm upon DNA replication stress; YOR342C has a paralog, YAL037W, that arose from the whole genome duplication	biological_process	molecular_function	nucleus|cytoplasm
YKL067W	YKL067W	YNK1	hom	Verified	0.363814129411802	0.35799840546016	no	1782	0.33670036537492	1117	NA	FT	RESPONSE TO DNA DAMAGE|NUCLEOTIDE METABOLISM	MITOCHONDRION		Nucleoside diphosphate kinase; catalyzes the transfer of gamma phosphates from nucleoside triphosphates, usually ATP, to nucleoside diphosphates by a mechanism that involves formation of an autophosphorylated enzyme intermediate; protein abundance increases in response to DNA replication stress	nucleoside diphosphate phosphorylation|nucleoside triphosphate biosynthetic process|response to DNA damage stimulus	nucleoside diphosphate kinase activity	cytosol|mitochondrion|mitochondrial intermembrane space
YBR246W	YBR246W	RRT2	hom	Verified	0.362957494401674	0.358318318353841	no	1783	0.371478471128838	1238	NA	FT	VESICLE-MEDIATED TRANSPORT			Protein required for last step of diphthamide biosynthesis; deletion leads to resistance to sordarin and accumulation of diphthine; WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rtt10p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription	peptidyl-diphthamide biosynthetic process from peptidyl-histidine|endocytic recycling	molecular_function	endosome|cytoplasm
YDL071C_d	YDL071C	YDL071C	hom	Dubious	0.362759393361007	0.358392313947565	no	1784	0.381952528594469	1283	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF BDF2/YDL070W	Unknown	Unknown	Unknown
YER079W_p	YER079W	YER079W	hom	Uncharacterized	0.361617370913909	0.358818990933389	no	1785	0.34985645680173	1145	NA	FT		NUCLEUS		Putative protein of unknown function	biological_process	molecular_function	nucleus|cytoplasm
YML111W	YML111W	BUL2	hom	Verified	0.3614032904023	0.35889899430447	no	1786	0.351129536964731	1177	NA	FT			UBIQUITIN LIGASE COMPLEX	Component of the Rsp5p E3-ubiquitin ligase complex; involved in intracellular amino acid permease sorting, functions in heat shock element mediated gene expression, essential for growth in stress conditions; BUL2 has a paralog, BUL1, that arose from the whole genome duplication	protein polyubiquitination|protein monoubiquitination	ubiquitin-ubiquitin ligase activity	ubiquitin ligase complex|cytoplasm
YBR113W_d	YBR113W	YBR113W	hom	Dubious	0.361201604381563	0.358974371431309	no	1787	0.329819056387223	1090	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CYC8	Unknown	Unknown	Unknown
YOR385W_p	YOR385W	YOR385W	hom	Uncharacterized	0.36074351030396	0.359145597622554	no	1788	0.361133183001592	1197	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YOR385W is not an essential gene	biological_process	molecular_function	cytoplasm
YHL044W_p	YHL044W	YHL044W	hom	Uncharacterized	0.360727292144477	0.35915166015751	no	1789	0.349137716407795	1176	NA	FT		PLASMA MEMBRANE		Putative integral membrane protein, member of DUP240 gene family; green fluorescent protein (GFP)-fusion protein localizes to the plasma membrane in a punctate pattern	biological_process	molecular_function	plasma membrane
YGL210W	YGL210W	YPT32	hom	Verified	0.360648039883997	0.359181286076096	no	1790	0.335133901513948	1108	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING	ENDOMEMBRANE SYSTEM|MITOCHONDRION|GOLGI APPARATUS		Rab family GTPase involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; protein abundance increases in response to DNA replication stress; YPT32 has a paralog, YPT31, that arose from the whole genome duplication	early endosome to Golgi transport|vesicle-mediated transport|exocytosis	GTPase activity	endosome|mitochondrial outer membrane|Golgi apparatus
YDR022C	YDR022C	ATG31	hom	Verified	0.358366398683771	0.360034567013311	no	1791	0.351719898140588	1173	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|CHROMOSOME SEGREGATION	CYTOSKELETON		Autophagy-specific protein required for autophagosome formation; may form a complex with Atg17p and Atg29p that localizes other proteins to the pre-autophagosomal structure; high-copy suppressor of CIK1 deletion	autophagy|mitochondrion degradation|piecemeal microautophagy of nucleus	molecular_function	pre-autophagosomal structure|cytoplasm
YNL128W	YNL128W	TEP1	hom	Verified	0.358251992575194	0.360077370655663	no	1792	0.348561726956902	1149	NA	FT	CELL WALL ORG/BIOGENESIS			PTEN homolog with no demonstrated inositol lipid phosphatase activity; plays a role in normal sporulation; homolog of human tumor suppressor gene PTEN/MMAC1/TEP1 and fission yeast ptn1	ascospore wall assembly|phosphatidylinositol dephosphorylation	molecular_function	cytoplasm
YDR090C_p	YDR090C	YDR090C	hom	Uncharacterized	0.356877593648096	0.360591722152699	no	1793	0.383438743247229	1272	NA	FT		PLASMA MEMBRANE		Putative protein of unknown function	biological_process	molecular_function	integral to membrane
YMR311C	YMR311C	GLC8	hom	Verified	0.356641017261972	0.360680283367472	no	1794	0.371406484234518	1236	NA	FT	SIGNALING|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|CHROMOSOME SEGREGATION	NUCLEUS		Regulatory subunit of protein phosphatase 1 (Glc7p); involved in glycogen metabolism and chromosome segregation; proposed to regulate Glc7p activity via conformational alteration; ortholog of the mammalian protein phosphatase inhibitor 2; protein abundance increases in response to DNA replication stress	chromosome segregation|glycogen biosynthetic process	enzyme activator activity	nucleus|cytoplasm
YKL055C	YKL055C	OAR1	hom	Verified	0.356425919549871	0.360760810631273	no	1795	0.375638639724714	1256	NA	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Mitochondrial 3-oxoacyl-[acyl-carrier-protein] reductase, may comprise a type II mitochondrial fatty acid synthase along with Mct1p	fatty acid metabolic process|aerobic respiration	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity	mitochondrion
YOR179C	YOR179C	SYC1	hom	Verified	0.355838960952246	0.360980584815076	no	1796	0.360475655659189	1224	NA	FT	TRANSCRIPTION FROM RNA POL II|RNA PROCESSING	NUCLEUS		Subunit of the APT subcomplex of cleavage and polyadenylation factor; may have a role in 3' end formation of both polyadenylated and non-polyadenylated RNAs; SYC1 has a paralog, YSH1, that arose from the whole genome duplication	termination of RNA polymerase II transcription, exosome-dependent|termination of RNA polymerase II transcription, poly(A)-coupled	RNA binding	mRNA cleavage and polyadenylation specificity factor complex|nucleus
YER052C	YER052C	HOM3	hom	Verified	0.355678112839222	0.361040818992343	no	1797	0.364239036324254	1215	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis	threonine biosynthetic process|methionine biosynthetic process|homoserine biosynthetic process	aspartate kinase activity	cytoplasm
YBR297W	YBR297W	MAL33	hom	Verified	0.355460332975219	0.361122378383718	no	1798	0.362437264941219	1200	NA	FT	TRANSCRIPTION FROM RNA POL II|CARBOHYDRATE METABOLISM	NUCLEUS		MAL-activator protein, part of complex locus MAL3; nonfunctional in genomic reference strain S288C	cellular carbohydrate metabolic process|regulation of transcription, DNA-dependent	sequence-specific DNA binding transcription factor activity	nucleus
YMR055C	YMR055C	BUB2	hom	Verified	0.354409022352353	0.361516186978367	no	1799	0.355996251017441	1215	NA	FT	CELL CYCLE|SIGNALING|CELL DIVISION|NUCLEOTIDE METABOLISM	CYTOSKELETON		Mitotic exit network regulator, forms GTPase-activating Bfa1p-Bub2p complex that binds Tem1p and spindle pole bodies, blocks cell cycle progression before anaphase in response to spindle and kinetochore damage	regulation of exit from mitosis|mitotic cell cycle spindle orientation checkpoint	GTPase activator activity	spindle pole body
YMR251W-A	YMR251W-A	HOR7	hom	Verified	0.353714660386936	0.361776367302248	no	1800	0.344524208738307	1146	NA	FT		ENDOPLASMIC RETICULUM|PLASMA MEMBRANE		Protein of unknown function; overexpression suppresses Ca2+ sensitivity of mutants lacking inositol phosphorylceramide mannosyltransferases Csg1p and Csh1p; transcription is induced under hyperosmotic stress and repressed by alpha factor; HOR7 has a paralog, DDR2, that arose from the whole genome duplication	plasma membrane organization	molecular_function	endoplasmic reticulum|plasma membrane
YER119C-A_d	YER119C-A	YER119C-A	hom	Dubious	0.353460848340285	0.361871487690466	no	1801	0.383429664476884	1301	NA	FF				Dubious open reading frame, not conserved in closely related Saccharomyces species; deletion mutation blocks replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene SCS2	Unknown	Unknown	Unknown
YDR369C	YDR369C	XRS2	hom	Verified	0.353121096143982	0.361998828970231	no	1802	0.369569498002801	1250	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS		Protein required for DNA repair; component of the Mre11 complex, which is involved in double strand breaks, meiotic recombination, telomere maintenance, and checkpoint signaling	double-strand break repair via nonhomologous end joining|meiotic DNA double-strand break formation|base-excision repair|telomere maintenance|sporulation resulting in formation of a cellular spore|double-strand break repair via break-induced replication	single-stranded telomeric DNA binding|protein binding, bridging|DNA binding|double-stranded telomeric DNA binding|telomeric DNA binding|G-quadruplex DNA binding	nucleus|Mre11 complex
YIR013C	YIR013C	GAT4	hom	Verified	0.352999700616491	0.362044332490007	no	1803	0.342555158203868	1174	NA	FT		NUCLEUS		Protein containing GATA family zinc finger motifs	transcription, DNA-dependent	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	nucleus
YDR147W	YDR147W	EKI1	hom	Verified	0.352197237008238	0.362345174459685	no	1804	0.373049002466958	1230	NA	FT	LIPID METABOLISM			Ethanolamine kinase; primarily responsible for phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway; exhibits some choline kinase activity, thus contributing to phosphatidylcholine synthesis via the CDP-choline pathway; EKI1 has a paralog, CKI1, that arose from the whole genome duplication	phosphatidylethanolamine biosynthetic process|phosphatidylcholine biosynthetic process	ethanolamine kinase activity|choline kinase activity	cytoplasm
YIL105C	YIL105C	SLM1	hom	Verified	0.352113208686643	0.362376681427439	no	1805	0.34585604341798	1144	NA	FT	VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|SIGNALING|CYTOSKELETON ORGANIZATION	MITOCHONDRION|PLASMA MEMBRANE		Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm2p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; phosphorylated by the TORC2 complex; protein abundance increases in response to DNA replication stress; SLM1 has a paralog, SLM2, that arose from the whole genome duplication	eisosome assembly|TOR signaling cascade|regulation of cell growth|actin filament bundle assembly|endosomal transport|establishment or maintenance of actin cytoskeleton polarity|actin cytoskeleton organization	phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol binding|sphingolipid binding	eisosome|mitochondrion|membrane raft|plasma membrane|cytoplasm
YDR003W-A_p	YDR003W-A	YDR003W-A	hom	Uncharacterized	0.351766456106949	0.362506708429675	no	1806	0.376559756647489	1224	NA					Putative protein of unknown function; identified by expression profiling and mass spectrometry	biological_process	molecular_function	cellular_component
YGR184C	YGR184C	UBR1	hom	Verified	0.351482769749156	0.362613098344142	no	1807	0.373714627387914	1222	NA	FT	PROTEOLYSIS			E3 ubiquitin ligase (N-recognin); forms heterodimer with Rad6p to ubiquitinate substrates in the N-end rule pathway; regulates peptide transport via Cup9p ubiquitination; plays a major role in targeting cytosolic misfolded proteins for degradation; mutation in human UBR1 causes Johansson-Blizzard Syndrome (JBS)	regulation of dipeptide transport|ubiquitin-dependent protein catabolic process via the N-end rule pathway|cytoplasm-associated proteasomal ubiquitin-dependent protein catabolic process|protein polyubiquitination	ubiquitin-protein ligase activity	proteasome regulatory particle, base subcomplex|cytoplasm
YML021C	YML021C	UNG1	hom	Verified	0.350969534200821	0.362805602251329	no	1808	0.366766926653981	1240	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS|MITOCHONDRION		Uracil-DNA glycosylase, required for repair of uracil in DNA formed by spontaneous cytosine deamination, not required for strand-specific mismatch repair, cell-cycle regulated, expressed in late G1, localizes to mitochondria and nucleus	DNA repair	uracil DNA N-glycosylase activity	mitochondrion|nucleus
YLL014W	YLL014W	EMC6	hom	Verified	0.35017723926773	0.363102843563225	no	1809	0.397054913329322	1322	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm F33D4.7/EMC-6, fly CG11781, human TMEM93	protein folding in endoplasmic reticulum	molecular_function	ER membrane protein complex|integral to membrane|endoplasmic reticulum
YLL048C	YLL048C	YBT1	hom	Verified	0.350095154585861	0.363133643579195	no	1810	0.365498535607009	1219	NA	FT	NUCLEOTIDE METABOLISM			Transporter of the ATP-binding cassette (ABC) family; involved in bile acid transport; negative regulator of vacuole fusion; regulates the release of lumenal Ca2+ stores; similar to mammalian bile transporters	bile acid and bile salt transport	bile acid-exporting ATPase activity	integral to membrane|fungal-type vacuole
YIL092W_p	YIL092W	YIL092W	hom	Uncharacterized	0.347483457822667	0.364114071977266	no	1811	0.364443285792259	1225	NA	FT		NUCLEUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus	biological_process	molecular_function	nucleus|cytoplasm
YGL153W	YGL153W	PEX14	hom	Verified	0.346703450203817	0.364407058965415	no	1812	0.364208331691332	1192	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|PEROXISOME ORGANIZATION			Peroxisomal membrane peroxin that is a central component of the peroxisomal protein import machinery; interacts with both PTS1 (Pex5p) and PTS2 (Pex7p), peroxisomal matrix protein signal recognition factors and membrane receptor Pex13p	protein import into peroxisome matrix, docking	protein binding, bridging	peroxisomal membrane
YER142C	YER142C	MAG1	hom	Verified	0.346062698371325	0.364647797893371	no	1813	0.346747251351472	1160	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		3-methyl-adenine DNA glycosylase; involved in protecting DNA against alkylating agents; initiates base excision repair by removing damaged bases to create abasic sites that are subsequently repaired; protein abundance increases in response to DNA replication stress	base-excision repair, AP site formation|DNA dealkylation involved in DNA repair	alkylbase DNA N-glycosylase activity	nucleus
YAL027W	YAL027W	SAW1	hom	Verified	0.345986622247083	0.364676384245554	no	1814	0.322862312602001	1056	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		5'- and 3'-flap DNA binding protein; stimulates the endonuclease activity of Rad1/Rad10p; involved in Rad1p/Rad10p-dependent removal of 3'-nonhomologous tails during double-strand break repair via single-strand annealing; green fluorescent protein (GFP)-fusion protein localizes to the nucleus	double-strand break repair via single-strand annealing, removal of nonhomologous ends	molecular_function	nucleus
YJR031C	YJR031C	GEA1	hom	Verified	0.34548074002174	0.364866493599604	no	1815	0.352617574046701	1167	NA	FT	VESICLE-MEDIATED TRANSPORT|SIGNALING|CYTOSKELETON ORGANIZATION|RESPONSE TO NUTRIENT LEVELS	GOLGI APPARATUS		Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs); involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; GEA1 has a paralog, GEA2, that arose from the whole genome duplication	retrograde vesicle-mediated transport, Golgi to ER|ER to Golgi vesicle-mediated transport|macroautophagy|intra-Golgi vesicle-mediated transport|actin cytoskeleton organization	ARF guanyl-nucleotide exchange factor activity	integral to membrane|Golgi cis cisterna|Golgi-associated vesicle|extrinsic to membrane
YOR265W	YOR265W	RBL2	hom	Verified	0.345187380247979	0.364976752739193	no	1816	0.379821842349106	1268	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION	CYTOSKELETON		Protein involved in microtubule morphogenesis; required for protection from excess free beta-tubulin; proposed to be involved the folding of beta-tubulin; similar to mouse beta-tubulin cofactor A; protein abundance increases in response to DNA replication stress	tubulin complex assembly|tubulin complex biogenesis	tubulin binding|beta-tubulin binding	cytoplasm
YEL014C_d	YEL014C	YEL014C	hom	Dubious	0.344799418821828	0.365122585013609	no	1817	0.349721028464928	1149	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YGL255W	YGL255W	ZRT1	hom	Verified	0.343687605159189	0.365540616817218	no	1818	0.345790632119528	1142	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		High-affinity zinc transporter of the plasma membrane, responsible for the majority of zinc uptake; transcription is induced under low-zinc conditions by the Zap1p transcription factor	high-affinity zinc ion transport	high affinity zinc uptake transmembrane transporter activity	integral to membrane|integral to plasma membrane
YLR038C	YLR038C	COX12	hom	Verified	0.342580643781008	0.365956982929756	no	1819	0.35481700318614	1186	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Subunit VIb of cytochrome c oxidase; cytochrome c oxidase is also known as respiratory Complex IV and is the terminal member of the mitochondrial inner membrane electron transport chain; required for assembly of cytochrome c oxidase but not required for activity after assembly; phosphorylated; easily released from the intermembrane space, suggesting a loose association with Complex IV	mitochondrial respiratory chain complex IV assembly	cytochrome-c oxidase activity	mitochondrion|integral to membrane|mitochondrial respiratory chain complex IV
YNR033W	YNR033W	ABZ1	hom	Verified	0.34062740868311	0.36669204649035	no	1820	0.35100946609772	1151	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM			Para-aminobenzoate (PABA) synthase; has similarity to Escherichia coli PABA synthase components PabA and PabB; required for the synthesis of para-aminobenzoic acid, an important intermediate for folate and ubiquinone Q biosynthesis; protein abundance increases in response to DNA replication stress	para-aminobenzoic acid biosynthetic process	4-amino-4-deoxychorismate synthase activity	cytoplasm
YDL223C	YDL223C	HBT1	hom	Verified	0.340180593960569	0.366860265714618	no	1821	0.391476560985221	1310	NA					Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis	cell morphogenesis involved in conjugation with cellular fusion	molecular_function	plasma membrane|mating projection
YOR379C_d	YOR379C	YOR379C	hom	Dubious	0.34004349741884	0.36691188569045	no	1822	0.35278112864574	1181	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR378W	Unknown	Unknown	Unknown
YOR318C_d	YOR318C	YOR318C	hom	Dubious	0.339701138228276	0.367040802243182	no	1823	0.366265072344117	1229	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcript is predicted to be spliced but there is no evidence that it is spliced in vivo	Unknown	Unknown	Unknown
YLR176C	YLR176C	RFX1	hom	Verified	0.339241062943046	0.367214068814729	no	1824	0.364759540639942	1242	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Major transcriptional repressor of DNA-damage-regulated genes, recruits repressors Tup1p and Cyc8p to their promoters; involved in DNA damage and replication checkpoint pathway; similar to a family of mammalian DNA binding RFX1-4 proteins	negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding	nucleus|cytoplasm
YNL136W	YNL136W	EAF7	hom	Verified	0.337740030760968	0.367779552661333	no	1825	0.378252689311223	1265	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE	NUCLEUS	HISTONE ACETYLTRANSFERASE	Subunit of the NuA4 histone acetyltransferase complex, which acetylates the N-terminal tails of histones H4 and H2A	DNA repair|histone acetylation|regulation of transcription from RNA polymerase II promoter	molecular_function	histone acetyltransferase complex|nucleus|NuA4 histone acetyltransferase complex
YOL057W	YOL057W	YOL057W	hom	Verified	0.336534842032886	0.368233791003086	no	1826	0.360288744583977	1195	NA	FT	PROTEOLYSIS	NUCLEUS		Dipeptidyl-peptidase III; cleaves dipeptides from the amino terminus of target proteins; highly active on synthetic substrate Arg-Arg-2-naphthylamide; mammalian ortholog may be a biomarker for some cancers	proteolysis	dipeptidyl-peptidase activity	nucleus|cytoplasm
YDR496C	YDR496C	PUF6	hom	Verified	0.336446070964989	0.368267256311676	no	1827	0.348363458362652	1150	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION	NUCLEUS|SITE OF POLARIZED GROWTH	RIBOSOME	Pumilio-homology domain protein that binds the 3' UTR of ASH1 mRNA and represses its translation, resulting in proper asymmetric localization of ASH1 mRNA; also co-sediments with the 60S ribosomal subunit and is required for its biogenesis	ribosomal large subunit biogenesis|negative regulation of translation	mRNA 3'-UTR binding|translation repressor activity, nucleic acid binding	nucleolus|nucleus|large ribosomal subunit
YER154W	YER154W	OXA1	hom	Verified	0.336167766642852	0.368372179179811	no	1828	0.377970491750542	1267	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial inner membrane insertase, mediates the insertion of both mitochondrial- and nuclear-encoded proteins from the matrix into the inner membrane, interacts with mitochondrial ribosomes; conserved from bacteria to animals	protein insertion into mitochondrial membrane from inner side|mitochondrial genome maintenance|mitochondrial proton-transporting ATP synthase complex assembly	mitochondrial ribosome binding|membrane insertase activity	mitochondrion|mitochondrial inner boundary membrane|integral to membrane|mitochondrial crista|mitochondrial large ribosomal subunit
YJR014W	YJR014W	TMA22	hom	Verified	0.33540686595167	0.368659094676578	no	1829	0.320550179012034	1052	NA	FT	TRANSLATION		RIBOSOME	Protein of unknown function; associates with ribosomes and has a putative RNA binding domain; interacts with Tma20p; similar to human GRAP and human DRP1, which interacts with human Tma20p homolog MCT-1; protein abundance increases in response to DNA replication stress	biological_process	RNA binding	ribosome|cytoplasm
YGL045W	YGL045W	RIM8	hom	Verified	0.335377650588289	0.368670112477136	no	1830	0.387977161711991	1270	NA	FF|FT	VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Protein involved in proteolytic activation of Rim101p in response to alkaline pH; interacts with ESCRT-1 subunits Stp22p and Vps28p; essential for anaerobic growth; member of the arrestin-related trafficking adaptor family	meiosis|protein processing|invasive growth in response to glucose limitation|ubiquitin-dependent endocytosis	molecular_function	internal side of plasma membrane
YBR293W	YBR293W	VBA2	hom	Verified	0.335320780286421	0.368691559914926	no	1831	0.369316746711702	1277	NA					Permease of basic amino acids in the vacuolar membrane	basic amino acid transport|transmembrane transport	basic amino acid transmembrane transporter activity|drug transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane
YPR156C	YPR156C	TPO3	hom	Verified	0.335025400977237	0.368802962584101	no	1832	0.358555083688518	1192	NA	FT		PLASMA MEMBRANE		Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; specific for spermine; localizes to the plasma membrane; TPO3 has a paralog, TPO2, that arose from the whole genome duplication	spermine transport	spermine transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane|plasma membrane
YDL054C	YDL054C	MCH1	hom	Verified	0.333817605626703	0.369258598697589	no	1833	0.372858170336892	1279	NA					Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport	transport	monocarboxylic acid transmembrane transporter activity|transporter activity	integral to membrane|membrane
YJL214W	YJL214W	HXT8	hom	Verified	0.333258405666539	0.369469616979593	no	1834	0.364282047199011	1215	NA	FT		PLASMA MEMBRANE		Protein of unknown function with similarity to hexose transporter family members, expression is induced by low levels of glucose and repressed by high levels of glucose	hexose transport	mannose transmembrane transporter activity|glucose transmembrane transporter activity|fructose transmembrane transporter activity	integral to membrane|plasma membrane
YPL101W	YPL101W	ELP4	hom	Verified	0.332933446815938	0.369592260700677	no	1835	0.390212932075267	1303	NA	FT	TRANSCRIPTION FROM RNA POL II|RNA PROCESSING	NUCLEUS		Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity	regulation of transcription from RNA polymerase II promoter|tRNA wobble uridine modification	ATPase activity|tRNA binding	Elongator holoenzyme complex|cytoplasm
YJR032W	YJR032W	CPR7	hom	Verified	0.33210782305017	0.369903921568825	no	1836	0.381070845582299	1272	NA					Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity	protein refolding|response to stress	unfolded protein binding|peptidyl-prolyl cis-trans isomerase activity	cytosol
YDL130W-A	YDL130W-A	STF1	hom	Verified	0.331859721752329	0.369997592880825	no	1837	0.382053694726206	1285	NA	FT	NUCLEOTIDE METABOLISM	MITOCHONDRION		Protein involved in regulation of the mitochondrial F1F0-ATP synthase; Stf1p and Stf2p act as stabilizing factors that enhance inhibitory action of the Inh1p protein; protein abundance increases in response to DNA replication stress	negative regulation of ATPase activity	molecular_function	mitochondrion|mitochondrial proton-transporting ATP synthase complex
YKL148C	YKL148C	SDH1	hom	Verified	0.331434734705721	0.37015806580121	no	1838	0.389914506875579	1297	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Flavoprotein subunit of succinate dehydrogenase; couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain; FAD binding to Sdh1p is required for the assembly of the succinate dehydrogenase subunits	cellular respiration|mitochondrial electron transport, succinate to ubiquinone|tricarboxylic acid cycle	succinate dehydrogenase (ubiquinone) activity|flavin adenine dinucleotide binding	mitochondrial respiratory chain complex II|mitochondrion|mitochondrial membrane
YBR177C	YBR177C	EHT1	hom	Verified	0.331189821862891	0.370250553898233	no	1839	0.361782482937255	1198	NA	FT	KETONE METABOLISM|LIPID METABOLISM	MITOCHONDRION		Acyl-coenzymeA:ethanol O-acyltransferase; plays a minor role in medium-chain fatty acid ethyl ester biosynthesis; possesses short-chain esterase activity; localizes to lipid particles and the mitochondrial outer membrane; EHT1 has a paralog, EEB1, that arose from the whole genome duplication	medium-chain fatty acid catabolic process|medium-chain fatty acid biosynthetic process|cellular lipid metabolic process	short-chain carboxylesterase activity|alcohol O-butanoyltransferase activity|serine hydrolase activity	mitochondrial outer membrane|mitochondrion|lipid particle
YBR099C_d	YBR099C	YBR099C	hom	Dubious	0.329164458684474	0.371015692620248	no	1840	0.366684785139959	1202	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene MMS4	Unknown	Unknown	Unknown
YDR111C_p	YDR111C	ALT2	hom	Uncharacterized	0.329031698042709	0.371065864590759	no	1841	0.366085870903423	1197	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Catalytically inactive paralog of ALT1, an alanine transaminase; expression is repressed in the presence of alanine and repression is mediated by Nrg1p	biological_process	transaminase activity	nucleus|cytoplasm
YMR105C	YMR105C	PGM2	hom	Verified	0.32821018220623	0.371376374804515	no	1842	0.362899620722134	1198	NA	FT	ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|ION HOMEOSTASIS|GEN. OF PRECURSOR METABOLITES AND ENERGY			Phosphoglucomutase; catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism; functions as the acceptor for a Glc-phosphotransferase; protein abundance increases in response to DNA replication stress	glucose 6-phosphate metabolic process|cellular calcium ion homeostasis|galactose catabolic process|cellular cation homeostasis|glucose 1-phosphate metabolic process|trehalose biosynthetic process|UDP-glucose metabolic process|glycogen biosynthetic process	phosphoglucomutase activity	cytoplasm
YJR074W	YJR074W	MOG1	hom	Verified	0.327715998943336	0.371563202726372	no	1843	0.366404350122427	1215	NA	FT	PROTEIN LOCALIZATION|RNA LOCALIZATION	NUCLEUS		Conserved nuclear protein that interacts with GTP-Gsp1p, which is a Ran homolog of the Ras GTPase family, and stimulates nucleotide release, involved in nuclear protein import, nucleotide release is inhibited by Yrb1p	protein import into nucleus	Ran GTPase binding	nucleus
YGR224W	YGR224W	AZR1	hom	Verified	0.327216518944755	0.371752063847583	no	1844	0.3510961461464	1189	NA	FT		PLASMA MEMBRANE		Plasma membrane transporter of the major facilitator superfamily, involved in resistance to azole drugs such as ketoconazole and fluconazole	azole transport	azole transporter activity	integral to membrane|plasma membrane
YHL012W_p	YHL012W	YHL012W	hom	Uncharacterized	0.32601137327333	0.372207875100875	no	1845	0.347351900185374	1175	NA					Putative UTP glucose-1-phosphate uridylyltransferase; YHL012W has a paralog, UGP1, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YDR217C	YDR217C	RAD9	hom	Verified	0.325165955871238	0.372527736547678	no	1846	0.364813858940331	1233	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		DNA damage-dependent checkpoint protein; required for cell-cycle arrest in G1/S, intra-S, and G2/M; transmits checkpoint signal by activating Rad53p and Chk1p; hyperphosphorylated by Mec1p and Tel1p; multiple cyclin dependent kinase consensus sites and the C-terminal BRCT domain contribute to DNA damage checkpoint activation; potential Cdc28p substrate	DNA repair|mitotic cell cycle G1/S transition DNA damage checkpoint|regulation of cell cycle|intra-S DNA damage checkpoint|nucleotide-excision repair|DNA damage checkpoint|positive regulation of transcription from RNA polymerase II promoter	double-stranded DNA binding|histone binding	chromatin|nucleus
YIR044C	YIR044C	YIR044C	hom	pseudogene	0.324875083994115	0.3726378075001	no	1847	0.371554457142718	1246	NA					Possible pseudogene in strain S288C; YIR044C and the adjacent ORF, YIR043C, together may encode a non-functional member of the conserved, often subtelomerically-encoded Cos protein family	biological_process	molecular_function	cellular_component
YLR177W_p	YLR177W	YLR177W	hom	Uncharacterized	0.324186468451324	0.372898432986541	no	1848	0.373342875082463	1217	NA					Putative protein of unknown function; phosphorylated by Dbf2p-Mob1p in vitro; some strains contain microsatellite polymophisms at this locus; not an essential gene; YLR177W has a paralog, PSP1, that arose from the whole genome duplication	biological_process	molecular_function	cytoplasm
YPL125W	YPL125W	KAP120	hom	Verified	0.323267108676985	0.373246480655022	no	1849	0.381384566436265	1268	NA	FT	PROTEIN LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	Karyopherin responsible for the nuclear import of ribosome maturation factor Rfp1p	protein import into nucleus|transcription factor import into nucleus	protein transporter activity|structural constituent of nuclear pore	integral to membrane|nucleus|nuclear pore|cytoplasm
YJL206C_p	YJL206C	YJL206C	hom	Uncharacterized	0.323149080353576	0.373291170860225	no	1850	0.368847534662954	1250	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Putative protein of unknown function; similar to transcriptional regulators from the Zn[2]-Cys[6] binuclear cluster protein family; mRNA is weakly cell cycle regulated, peaking in S phase; induced rapidly upon MMS treatment	biological_process	molecular_function	cellular_component
YNL063W	YNL063W	MTQ1	hom	Verified	0.323011301875928	0.373343341413494	no	1851	0.383514724769622	1271	NA	FT	TRANSLATION	MITOCHONDRION		S-adenosylmethionine-dependent methyltransferase; methylates translational release factor Mrf1p; similar to E.coli PrmC; is not an essential gene	translational readthrough	S-adenosylmethionine-dependent methyltransferase activity	mitochondrion
YER007C-A	YER007C-A	TMA20	hom	Verified	0.322365839622151	0.37358778003168	no	1852	0.360444565765725	1216	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION			Protein of unknown function that associates with ribosomes; has a putative RNA binding domain; interacts with Tma22p; null mutant exhibits translation defects; has homology to human oncogene MCT-1; protein abundance increases in response to DNA replication stress	ribosome biogenesis	RNA binding	ribosome|cytoplasm
YHR143W	YHR143W	DSE2	hom	Verified	0.321813900923849	0.373796841329394	no	1853	0.438877729370095	1437	NA	FF|FT	CELL WALL ORG/BIOGENESIS|CELL DIVISION			Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother; expression is repressed by cAMP	cytokinesis, completion of separation|pseudohyphal growth	glucosidase activity	extracellular region|fungal-type cell wall
YKL090W	YKL090W	CUE2	hom	Verified	0.321545108941685	0.373898666811899	no	1854	0.36586351389127	1188	NA					Protein of unknown function; has two CUE domains that bind ubiquitin, which may facilitate intramolecular monoubiquitination	biological_process	ubiquitin binding	cellular_component
YDR104C	YDR104C	SPO71	hom	Verified	0.321537687942549	0.373901478206709	no	1855	0.349654301908387	1167	NA	FT	CELL WALL ORG/BIOGENESIS			Meiosis-specific protein of unknown function, required for spore wall formation during sporulation, in particular for the proper size of the prospore membrane (PSM); interacts with SPO1; dispensable for both nuclear divisions during meiosis; contains two PH domains	ascospore wall assembly	molecular_function	ascospore wall
YBR069C	YBR069C	TAT1	hom	Verified	0.32102817095456	0.374094521270274	no	1856	0.474093920383423	1556	NA	FF|FT		PLASMA MEMBRANE		Amino acid transporter for valine, leucine, isoleucine, and tyrosine; low-affinity tryptophan and histidine transporter; overexpression confers FK506 and FTY720 resistance; protein abundance increases in response to DNA replication stress	amino acid transport|tyrosine transport|tryptophan transport|transmembrane transport	amino acid transmembrane transporter activity|low-affinity tryptophan transmembrane transporter activity	integral to membrane|plasma membrane
YLL051C	YLL051C	FRE6	hom	Verified	0.320494810691543	0.374296631774936	no	1857	0.352512655329393	1199	NA	FT	ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|GEN. OF PRECURSOR METABOLITES AND ENERGY			Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels	intracellular sequestering of iron ion|copper ion import	ferric-chelate reductase activity	fungal-type vacuole membrane|integral to membrane|fungal-type vacuole
YPL224C	YPL224C	MMT2	hom	Verified	0.32018852754214	0.374412709739047	no	1858	0.361395023839304	1200	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Putative metal transporter involved in mitochondrial iron accumulation; closely related to Mmt1p	cellular iron ion homeostasis	molecular_function	mitochondrion|integral to membrane
YBR165W	YBR165W	UBS1	hom	Verified	0.319574443317369	0.374645475228332	no	1859	0.359422489389405	1198	NA	FT	PROTEIN LOCALIZATION	NUCLEUS		Ubiquitin-conjugating enzyme suppressor that functions as a general positive regulator of Cdc34p activity; nuclear protein that may represent a link between nucleocytoplasmic transport and ubiquitin ligase activity	protein export from nucleus|protein ubiquitination	molecular_function	nucleus
YER046W-A_d	YER046W-A	YER046W-A	hom	Dubious	0.319564684532594	0.374649174614834	no	1860	0.369658514606374	1238	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YHR007C-A_p	YHR007C-A	YHR007C-A	hom	Uncharacterized	0.319533252146727	0.374661090167024	no	1861	0.360819217156604	1206	NA					Putative protein of unknown function; identified by expression profiling and mass spectrometry	biological_process	molecular_function	cellular_component
YGR058W	YGR058W	PEF1	hom	Verified	0.319079776273411	0.374833009470549	no	1862	0.367656944091439	1239	NA	FT	CELL CYCLE|CELL DIVISION	NUCLEUS|SITE OF POLARIZED GROWTH		Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly	bipolar cellular bud site selection|regulation of COPII vesicle coating|axial cellular bud site selection	zinc ion binding|calcium ion binding	cytosol|site of polarized growth|nucleus|cellular bud neck|cytoplasm
YDR075W	YDR075W	PPH3	hom	Verified	0.318950108968864	0.374882172808084	no	1863	0.357167322458037	1175	NA	FT	CELL CYCLE|SIGNALING|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Catalytic subunit of protein phosphatase PP4 complex; active complex is composed of Pph3p and Psy2p, with Psy4p apparently providing additional substrate specificity in some cases; regulates recovery from the DNA damage checkpoint and also the gene conversion- and single-strand annealing-mediated pathways of meiotic double-strand break repair; involved in activation of Gln3p to alleviate nitrogen catabolite repression; Pph3p and Psy2p localize to foci on meiotic chromosomes	Unknown|signal transduction involved in meiotic recombination checkpoint|double-strand break repair via homologous recombination|protein dephosphorylation|positive regulation of nitrogen compound metabolic process	protein serine/threonine phosphatase activity	condensed nuclear chromosome|nucleus|cytoplasm
YGL197W	YGL197W	MDS3	hom	Verified	0.318771828276428	0.374949771223285	no	1864	0.390320229315332	1295	NA	FT	CELL CYCLE|SIGNALING	MITOCHONDRION		Putative component of the TOR regulatory pathway; negative regulator of early meiotic gene expression; required, with Pmd1p, for growth under alkaline conditions; has an N-terminal kelch-like domain	TOR signaling cascade|negative regulation of sporulation resulting in formation of a cellular spore	molecular_function	mitochondrion|cytoplasm
YGL081W_p	YGL081W	YGL081W	hom	Uncharacterized	0.31857657480598	0.375023809588296	no	1865	0.363299700213301	1209	NA					Putative protein of unknown function; non-essential gene; interacts genetically with CHS5, a gene involved in chitin biosynthesis	biological_process	molecular_function	cellular_component
YNL225C	YNL225C	CNM67	hom	Verified	0.318351825622806	0.37510903816462	no	1866	0.393721565790777	1315	NA	FT	CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION	NUCLEUS|CYTOSKELETON		Component of the spindle pole body outer plaque; required for spindle orientation and mitotic nuclear migration; CNM67 has a paralog, ADY3, that arose from the whole genome duplication	microtubule nucleation|mitotic spindle organization	structural constituent of cytoskeleton	outer plaque of spindle pole body|spindle pole body
YGR255C	YGR255C	COQ6	hom	Verified	0.318267543988984	0.375141000714884	no	1867	0.375394889289688	1257	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM	MITOCHONDRION		Putative flavin-dependent monooxygenase; involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; human COX6 can rescue a yeast cox6 mutant and is implicated in steroid-resistant nephrotic syndrome (SRNS)	ubiquinone biosynthetic process	N,N-dimethylaniline monooxygenase activity	mitochondrion|mitochondrial inner membrane
YGR276C	YGR276C	RNH70	hom	Verified	0.317780607058876	0.375325681049469	no	1868	0.373060620569953	1214	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		3'-5' exoribonuclease; required for maturation of 3' ends of 5S rRNA and tRNA-Arg3 from dicistronic transcripts	U5 snRNA 3'-end processing|generation of mature 3'-end of 5S rRNA generated by RNA polymerase III|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|tRNA 3'-trailer cleavage, exonucleolytic	3'-5'-exoribonuclease activity|3'-5' exonuclease activity	nucleus
YGL033W	YGL033W	HOP2	hom	Verified	0.315991428747905	0.376004506972363	no	1869	0.3945637082172	1314	NA	FF|FT	CELL CYCLE	NUCLEUS|CHROMOSOME		Meiosis-specific protein that localizes to chromosomes, preventing synapsis between nonhomologous chromosomes and ensuring synapsis between homologs; complexes with Mnd1p to promote homolog pairing and meiotic double-strand break repair	synapsis|reciprocal meiotic recombination	protein binding|double-stranded DNA binding	condensed nuclear chromosome
YOR147W	YOR147W	MDM32	hom	Verified	0.315982792278961	0.376007784637604	no	1870	0.364683583320309	1240	NA	FT	ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS	MITOCHONDRION		Mitochondrial inner membrane protein with similarity to Mdm31p, required for normal mitochondrial morphology and inheritance; interacts genetically with MMM1, MDM10, MDM12, and MDM34	mitochondrion inheritance|cellular ion homeostasis|mitochondrion organization	molecular_function	mitochondrion|mitochondrial inner membrane
YLR151C	YLR151C	PCD1	hom	Verified	0.315682887851152	0.376121608264962	no	1871	0.377009969189828	1250	NA	FT	NUCLEOTIDE METABOLISM			Peroxisomal pyrophosphatase with specificity for coenzyme A and CoA derivatives, may function to remove potentially toxic oxidized CoA disulfide from peroxisomes to maintain the capacity for beta-oxidation of fatty acids; nudix hydrolase family member	biological_process	pyrophosphatase activity	peroxisome
YBR156C	YBR156C	SLI15	hom	Verified	0.315557406788314	0.376169235667586	no	1872	0.377934735287387	1248	NA	FT	CELL DIVISION|PROTEIN PHOSPHORYLATION|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME|CYTOSKELETON		Subunit of the conserved chromosomal passenger complex (CPC; Ipl1p-Sli15p-Bir1p-Nbl1p), which regulates kinetochore-microtubule attachments, activation of the spindle tension checkpoint, and mitotic spindle disassembly	chromosome segregation|protein phosphorylation|regulation of cytokinesis	protein kinase activator activity	spindle microtubule|spindle midzone|chromosome passenger complex|kinetochore microtubule
YGL089C	YGL089C	MF(ALPHA)2	hom	Verified	0.315116246956461	0.376336696592942	no	1873	0.37236283293323	1254	NA	FT	SIGNALING			Mating pheromone alpha-factor, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)1, which is more highly expressed than MF(ALPHA)2	pheromone-dependent signal transduction involved in conjugation with cellular fusion	mating pheromone activity	extracellular region
YGR023W	YGR023W	MTL1	hom	Verified	0.314897452534454	0.376419757934019	no	1874	0.373265204863646	1232	NA	FT	CELL WALL ORG/BIOGENESIS|RESPONSE TO NUTRIENT LEVELS|RESPONSE TO OXIDATIVE STRESS	PLASMA MEMBRANE		Putative plasma membrane sensor, involved in cell integrity signaling and stress response during glucose starvation and oxidative stress; has structural and functional similarity to Mid2p	cellular response to glucose starvation|fungal-type cell wall organization|cellular response to oxidative stress	molecular_function	integral to plasma membrane
YJR129C_p	YJR129C	YJR129C	hom	Uncharacterized	0.314686502884256	0.376499846568378	no	1875	0.366965607480672	1235	NA					Putative protein of unknown function; predicted S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	biological_process	S-adenosylmethionine-dependent methyltransferase activity	cytoplasm
YHR184W	YHR184W	SSP1	hom	Verified	0.313692132894389	0.376877438220587	no	1876	0.379125598478192	1272	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL WALL ORG/BIOGENESIS|CELL DIVISION			Protein involved in the control of meiotic nuclear division and coordination of meiosis with spore formation; transcription is induced midway through meiosis	ascospore wall assembly|protein complex assembly	molecular_function	prospore membrane
YJL137C	YJL137C	GLG2	hom	Verified	0.313202516415847	0.377063403359864	no	1877	0.356846842710798	1192	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY			Glycogenin glucosyltransferase; self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; similar to mammalian glycogenin; GLG2 has a paralog, GLG1, that arose from the whole genome duplication	glycogen biosynthetic process	glycogenin glucosyltransferase activity	cytoplasm
YNL297C	YNL297C	MON2	hom	Verified	0.312812931427828	0.37721139511782	no	1878	0.421195833701909	1378	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Peripheral membrane protein with a role in endocytosis and vacuole integrity, interacts with Arl1p and localizes to the endosome; member of the Sec7p family of proteins	transport|endocytosis|protein targeting to vacuole|Golgi to endosome transport	guanyl-nucleotide exchange factor activity	cytosol|endosome|trans-Golgi network|extrinsic to membrane
YIL123W	YIL123W	SIM1	hom	Verified	0.312776059249873	0.37722540269696	no	1879	0.376807025059183	1264	NA	FT	CELL WALL ORG/BIOGENESIS			Protein of the SUN family (Sim1p, Uth1p, Nca3p, Sun4p) that may participate in DNA replication, promoter contains SCB regulation box at -300 bp indicating that expression may be cell cycle-regulated	fungal-type cell wall organization	molecular_function	fungal-type cell wall
YGR193C	YGR193C	PDX1	hom	Verified	0.312231912725597	0.377432140355969	no	1880	0.35147326461373	1204	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Dihydrolipoamide dehydrogenase (E3)-binding protein (E3BP) of the mitochondrial pyruvate dehydrogenase (PDH) complex, plays a structural role in the complex by binding and positioning E3 to the dihydrolipoamide acetyltransferase (E2) core	acetyl-CoA biosynthetic process from pyruvate	structural molecule activity	mitochondrion|mitochondrial pyruvate dehydrogenase complex
YBL039C	YBL039C	URA7	hom	Verified	0.311107600793489	0.377859411543919	no	1881	0.364684741886072	1207	NA	FT	KETONE METABOLISM|LIPID METABOLISM|AMINO ACID METABOLISM|NUCLEOTIDE METABOLISM			Major CTP synthase isozyme (see also URA8); catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis; capable of forming cytoplasmic filaments termed cytoophidium, especially during conditions of glucose depletion; URA7 has a paralog, URA8, that arose from the whole genome duplication	pyrimidine nucleobase biosynthetic process|CTP biosynthetic process|phospholipid biosynthetic process	CTP synthase activity	cytosol
YGR283C	YGR283C	YGR283C	hom	Verified	0.310821695547044	0.377968087699187	no	1882	0.374911810871591	1250	NA	FT		NUCLEUS		Putative S-adenosylmethionine-dependent methyltransferase; may interact with ribosomes, based on co-purification experiments; predicted to be involved in ribosome biogenesis; null mutant is resistant to fluconazole; GFP-fusion protein localizes to the nucleolus	biological_process	S-adenosylmethionine-dependent methyltransferase activity	ribosome|nucleolus
YLR034C	YLR034C	SMF3	hom	Verified	0.310297992557761	0.378167178788926	no	1883	0.37493564300439	1244	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Putative divalent metal ion transporter involved in iron homeostasis; transcriptionally regulated by metal ions; member of the Nramp family of metal transport proteins; protein abundance increases in response to DNA replication stress	cellular iron ion homeostasis|iron ion transport	metal ion transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane
YER072W	YER072W	VTC1	hom	Verified	0.308764048572426	0.378750509403574	no	1884	0.384056614601314	1258	NA	FT	MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT	ENDOPLASMIC RETICULUM		Subunit of the vacuolar transporter chaperone (VTC) complex; VTC complex is involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion; also has mRNA binding activity; protein abundance increases in response to DNA replication stress	polyphosphate metabolic process|vacuolar transport|microautophagy|vacuole fusion, non-autophagic	mRNA binding	integral to membrane|endoplasmic reticulum|vacuolar transporter chaperone complex|intrinsic to vacuolar membrane
YGL250W	YGL250W	RMR1	hom	Verified	0.308581680763424	0.378819878923243	no	1885	0.372781753711796	1272	NA	FT	CELL CYCLE	NUCLEUS		Protein required for meiotic recombination and gene conversion; null mutant displays reduced PIS1 expression and growth defects on non-fermentable carbon sources and minimal media; GFP-fusion protein localizes to both cytoplasm and nucleus	meiotic gene conversion|reciprocal meiotic recombination	molecular_function	nucleus|cytoplasm
YMR092C	YMR092C	AIP1	hom	Verified	0.307295682765321	0.379309160740397	no	1886	0.376580057345994	1217	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION	NUCLEUS|SITE OF POLARIZED GROWTH|CYTOSKELETON		Actin cortical patch component; interacts with the actin depolymerizing factor cofilin; required to restrict cofilin localization to cortical patches; contains WD repeats; protein increases in abundance and relocalizes from cytoplasm to plasma membrane upon DNA replication stress	actin filament depolymerization|response to osmotic stress	actin binding	nucleus|mating projection tip|cytoplasm|actin cortical patch
YLR304C	YLR304C	ACO1	hom	Verified	0.306765270693315	0.379511022236256	no	1887	0.434359294463579	1429	NA	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Aconitase, required for the tricarboxylic acid (TCA) cycle and also independently required for mitochondrial genome maintenance; phosphorylated; component of the mitochondrial nucleoid; mutation leads to glutamate auxotrophy	propionate metabolic process|glutamate biosynthetic process|tricarboxylic acid cycle|mitochondrial genome maintenance|citrate metabolic process	double-stranded DNA binding|aconitate hydratase activity|single-stranded DNA binding	mitochondrial nucleoid|cytosol|mitochondrion|mitochondrial matrix
YIL162W	YIL162W	SUC2	hom	Verified	0.306560835692349	0.379588833829414	no	1888	0.370412364706121	1241	NA	FT	CARBOHYDRATE METABOLISM	MITOCHONDRION		Invertase, sucrose hydrolyzing enzyme; a secreted, glycosylated form is regulated by glucose repression, and an intracellular, nonglycosylated enzyme is produced constitutively	sucrose catabolic process	beta-fructofuranosidase activity	mitochondrion|extracellular region|cytoplasm
YBR052C	YBR052C	RFS1	hom	Verified	0.306209591798521	0.379722534880943	no	1889	0.353359104457001	1155	NA	FT	OXIDATION-REDUCTION PROCESS			Protein of unknown function; member of a flavodoxin-like fold protein family that includes Pst2p and Ycp4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; RFS1 has a paralog, PST2, that arose from the whole genome duplication	biological_process	molecular_function	membrane raft|cytoplasm
YMR287C	YMR287C	DSS1	hom	Verified	0.30428750302815	0.380454432591321	no	1890	0.384771458123918	1238	NA	FT		MITOCHONDRION		3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs	mitochondrial RNA catabolic process	exoribonuclease II activity	mitochondrion|mitochondrial degradosome
YAL004W_d	YAL004W	YAL004W	hom	Dubious	0.30351824223681	0.380747473731378	no	1891	0.393822781199813	1322	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene SSA1/YAL005C	Unknown	Unknown	Unknown
YKR023W_p	YKR023W	YKR023W	hom	Uncharacterized	0.303137564570595	0.380892513873951	no	1892	0.321774554233904	1108	NA	FT		NUCLEUS|MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion|cytoplasm
YBR053C_p	YBR053C	YBR053C	hom	Uncharacterized	0.301956526800942	0.381342601754287	no	1893	0.36798176169177	1201	NA					Putative protein of unknown function; induced by cell wall perturbation	biological_process	molecular_function	cellular_component
YOR311C	YOR311C	DGK1	hom	Verified	0.300674321131018	0.381831425978773	no	1894	0.366495063715581	1223	NA	FT	VESICLE-MEDIATED TRANSPORT|KETONE METABOLISM|LIPID METABOLISM	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Diacylglycerol kinase, localized to the endoplasmic reticulum (ER); overproduction induces enlargement of ER-like membrane structures and suppresses a temperature-sensitive sly1 mutation; contains a CTP transferase domain	phosphatidic acid biosynthetic process	diacylglycerol kinase activity	integral to endoplasmic reticulum membrane|integral to membrane
YJR127C	YJR127C	RSF2	hom	Verified	0.299931533339645	0.382114690429227	no	1895	0.347330948930072	1168	NA	FT		NUCLEUS		Zinc-finger protein; involved in transcriptional control of both nuclear and mitochondrial genes, many of which specify products required for glycerol-based growth, respiration, and other functions; RSF2 has a paralog, TDA9, that arose from the whole genome duplication; relocalizes from nucleus to cytoplasm upon DNA replication stress	regulation of transcription, DNA-dependent	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	nucleus
YOR121C_d	YOR121C	YOR121C	hom	Dubious	0.29893305007319	0.382495564567326	no	1896	0.382998184577882	1235	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene GCY1/YOR120W	Unknown	Unknown	Unknown
YDR192C	YDR192C	NUP42	hom	Verified	0.298876852553026	0.382517004646145	no	1897	0.392876889959714	1285	NA	FT	PROTEIN LOCALIZATION|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	FG-nucleoporin component of central core of the nuclear pore complex (NPC); also part of the NPC cytoplasmic filaments; contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier and is involved in gene tethering at the nuclear periphery; interacts with Gle1p	poly(A)+ mRNA export from nucleus|NLS-bearing substrate import into nucleus|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|mRNA export from nucleus in response to heat stress|transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery	nucleocytoplasmic transporter activity|structural constituent of nuclear pore	nuclear pore central transport channel|integral to membrane|nuclear pore cytoplasmic filaments|nuclear pore
YCL033C	YCL033C	MXR2	hom	Verified	0.297842848716636	0.382911554652581	no	1898	0.379213076097142	1269	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|RESPONSE TO OXIDATIVE STRESS	MITOCHONDRION		Methionine-R-sulfoxide reductase, involved in the response to oxidative stress; protects iron-sulfur clusters from oxidative inactivation along with MXR1; involved in the regulation of lifespan	cellular response to oxidative stress	peptide-methionine (R)-S-oxide reductase activity	mitochondrion
YAL014C	YAL014C	SYN8	hom	Verified	0.296778364947693	0.383317861989989	no	1899	0.352786719241867	1174	NA	FT	PROTEIN LOCALIZATION			Endosomal SNARE related to mammalian syntaxin 8	transport	SNAP receptor activity	endosome
YMR101C	YMR101C	SRT1	hom	Verified	0.295742195934617	0.383713485053707	no	1900	0.369869479811225	1209	NA	FT	CARBOHYDRATE METABOLISM			Cis-prenyltransferase involved in synthesis of long-chain dolichols (19-22 isoprene units; as opposed to Rer2p which synthesizes shorter-chain dolichols); localizes to lipid bodies; transcription is induced during stationary phase	protein glycosylation	dehydrodolichyl diphosphate synthase activity|prenyltransferase activity	lipid particle
YDR248C_p	YDR248C	YDR248C	hom	Uncharacterized	0.295158062205359	0.383936568524409	no	1901	0.375372810617816	1240	NA	FT	KETONE METABOLISM|CARBOHYDRATE METABOLISM			Putative gluconokinase; sequence similarity to bacterial and human gluconokinase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; upregulated by deletion of the RNAP-II associated factor, PAF1	biological_process	molecular_function	cytoplasm
YGL214W_d	YGL214W	YGL214W	hom	Dubious	0.294697084275967	0.384112645363996	no	1902	0.372334511619787	1254	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; deletion mutation phenotype is likely due to the overlapping verified ORF SKI8/YGL213C	Unknown	Unknown	Unknown
YNR071C_p	YNR071C	YNR071C	hom	Uncharacterized	0.294194890514921	0.384304492379631	no	1903	0.384349364114976	1277	NA	FT	CARBOHYDRATE METABOLISM			Putative aldose 1-epimerase	biological_process	molecular_function	cellular_component
YGL230C_p	YGL230C	YGL230C	hom	Uncharacterized	0.292996276961893	0.384762498718362	no	1904	0.377106474344486	1257	NA					Putative protein of unknown function; non-essential gene	biological_process	molecular_function	cellular_component
YLR248W	YLR248W	RCK2	hom	Verified	0.292239453074633	0.385051774188576	no	1905	0.392100809389767	1315	NA	FT	CELL CYCLE|SIGNALING|PROTEIN PHOSPHORYLATION|RESPONSE TO OXIDATIVE STRESS			Protein kinase involved in response to oxidative and osmotic stress; identified as suppressor of S. pombe cell cycle checkpoint mutations; similar to CaM (calmodulin) kinases; RCK2 has a paralog, RCK1, that arose from the whole genome duplication	cellular response to oxidative stress|protein phosphorylation|osmosensory signaling pathway|regulation of meiosis	protein serine/threonine kinase activity|protein kinase activity	cytoplasm
YOR369C	YOR369C	RPS12	hom	Verified	0.292211683674591	0.385062389508907	no	1906	0.37295772562413	1218	NA	FT	TRANSLATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S12, no bacterial homolog	cytoplasmic translation	structural constituent of ribosome	cytosolic small ribosomal subunit
YAL049C	YAL049C	AIM2	hom	Verified	0.292117066090598	0.385098559318856	no	1907	0.382492820918281	1270	NA					Cytoplasmic protein involved in mitochondrial function or organization; null mutant displays reduced frequency of mitochondrial genome loss; potential Hsp82p interactor	biological_process	molecular_function	cytoplasm
YMR111C	YMR111C	YMR111C	hom	Verified	0.292113513649033	0.385099917343162	no	1908	0.372574837825811	1209	NA	FT		NUCLEUS		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR111C is not an essential gene; forms nuclear foci upon DNA replication stress	biological_process	molecular_function	nucleus
YPL173W	YPL173W	MRPL40	hom	Verified	0.29204794304605	0.385124983869924	no	1909	0.401247592685248	1317	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YBR141C_p	YBR141C	YBR141C	hom	Uncharacterized	0.291187848206714	0.385453827911803	no	1910	0.368286742785534	1202	NA	FT		NUCLEUS		Putative S-adenosylmethionine-dependent methyltransferase; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; YBR141C is not an essential gene	biological_process	S-adenosylmethionine-dependent methyltransferase activity	nucleolus
YBR120C	YBR120C	CBP6	hom	Verified	0.291085332411831	0.38549302874856	no	1911	0.382619579431351	1266	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial protein required for translation of the COB mRNA; forms a complex with Cbp3p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex	positive regulation of mitochondrial translation|mitochondrial respiratory chain complex III assembly	ribosome binding	mitochondrion|mitochondrial ribosome
YKR056W	YKR056W	TRM2	hom	Verified	0.290931587607253	0.385551821149965	no	1912	0.38153102679132	1258	NA	FT	RNA PROCESSING|RESPONSE TO DNA DAMAGE			tRNA methyltransferase, 5-methylates the uridine residue at position 54 of tRNAs and may also have a role in tRNA stabilization or maturation; endo-exonuclease with a role in DNA repair	double-strand break repair|DNA repair|tRNA modification	tRNA (m5U54) methyltransferase activity|double-stranded DNA specific 5'-3' exodeoxyribonuclease activity|single-stranded DNA specific endodeoxyribonuclease activity	cellular_component
YCL030C	YCL030C	HIS4	hom	Verified	0.290628139858782	0.385667868051294	no	1913	0.393325399376009	1300	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS			Multifunctional enzyme containing phosphoribosyl-ATP pyrophosphatase, phosphoribosyl-AMP cyclohydrolase, and histidinol dehydrogenase activities; catalyzes the second, third, ninth and tenth steps in histidine biosynthesis	histidine biosynthetic process	phosphoribosyl-ATP diphosphatase activity|phosphoribosyl-AMP cyclohydrolase activity|histidinol dehydrogenase activity	intracellular
YBL060W	YBL060W	YEL1	hom	Verified	0.288669932390789	0.386416987025506	no	1914	0.397014811089048	1300	NA	FT	PROTEIN LOCALIZATION|LIPID METABOLISM|SIGNALING	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Guanine nucleotide exchange factor specific for Arf3p; localized to the bud neck and tip; required for localization of Arf3p to the bud neck and tip	positive regulation of phosphatidylinositol biosynthetic process|protein localization|actin cortical patch localization	ARF guanyl-nucleotide exchange factor activity	cellular bud neck|cellular bud tip|cytoplasm
YOL075C_p	YOL075C	YOL075C	hom	Uncharacterized	0.288135419117143	0.386621540610017	no	1915	0.365137820391723	1222	NA	FT	NUCLEOTIDE METABOLISM			Putative ABC transporter	transport	ATPase activity, coupled to transmembrane movement of substances	integral to membrane|membrane
YLR445W	YLR445W	GMC2	hom	Verified	0.287968423930706	0.386685454678375	no	1916	0.395125065660791	1307	NA	FT	CELL CYCLE			Protein involved in meiotic progression; mutants are delayed in meiotic nuclear division and are defective in synaptonemal complex assembly; transcription is regulated by Ume6p and induced in response to alpha factor	meiosis|synaptonemal complex organization	molecular_function	cellular_component
YAL047C	YAL047C	SPC72	hom	Verified	0.287525134282195	0.38685512983155	no	1917	0.392738687692229	1305	NA	FT	CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION	NUCLEUS|CYTOSKELETON		Component of the cytoplasmic Tub4p (gamma-tubulin) complex, binds spindle pole bodies and links them to microtubules; has roles in astral microtubule formation and stabilization	microtubule nucleation|nuclear migration along microtubule|mitotic cell cycle spindle orientation checkpoint|mitotic spindle elongation|mitotic sister chromatid segregation	structural constituent of cytoskeleton	outer plaque of spindle pole body
YPR089W_p	YPR089W	YPR089W	hom	Uncharacterized	0.287052702529592	0.387035983328519	no	1918	0.389792253723568	1301	NA	FT		GOLGI APPARATUS		Protein of unknown function; exhibits genetic interaction with ERG11 and protein-protein interaction with Hsp82p	biological_process	molecular_function	cellular_component
YOR014W	YOR014W	RTS1	hom	Verified	0.286958407097004	0.387072083879425	no	1919	0.39562640048692	1329	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|SIGNALING|CHROMOSOME SEGREGATION	NUCLEUS|SITE OF POLARIZED GROWTH|CHROMOSOME|CYTOSKELETON		B-type regulatory subunit of protein phosphatase 2A (PP2A); Rts1p and Cdc55p are alternative regulatory subunits for PP2A catalytic subunits, Pph21p and Pph22p; PP2A-Rts1p protects cohesin when recruited by Sgo1p to the pericentromere; highly enriched at centromeres in the absence of Cdc55p; required for maintenance of septin ring organization during cytokinesis, for ring disassembly in G1 and for dephosphorylation of septin, Shs1p; homolog of the mammalian B' subunit of PP2A	mitotic cell cycle spindle orientation checkpoint|cellular protein localization|meiotic sister chromatid cohesion, centromeric|protein dephosphorylation	protein serine/threonine phosphatase activity	nucleus|spindle pole body|condensed nuclear chromosome, centromeric region|cellular bud neck|cytoplasm
YBR229C	YBR229C	ROT2	hom	Verified	0.285751956823487	0.387534053639582	no	1920	0.385652423568167	1285	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	ENDOPLASMIC RETICULUM|MITOCHONDRION		Glucosidase II catalytic subunit required for normal cell wall synthesis; mutations in rot2 suppress tor2 mutations, and are synthetically lethal with rot1 mutations	fungal-type cell wall biogenesis	alpha-glucosidase activity	glucosidase II complex|mitochondrion|endoplasmic reticulum|endoplasmic reticulum lumen
YNR012W	YNR012W	URK1	hom	Verified	0.285118543015806	0.387776662069389	no	1921	0.401728648372827	1337	NA	FT	NUCLEOTIDE METABOLISM	NUCLEUS		Uridine/cytidine kinase, component of the pyrimidine ribonucleotide salvage pathway that converts uridine into UMP and cytidine into CMP; involved in the pyrimidine deoxyribonucleotide salvage pathway, converting deoxycytidine into dCMP	pyrimidine-containing compound salvage	uridine kinase activity	nucleus|cytoplasm
YIL009W	YIL009W	FAA3	hom	Verified	0.282909517807878	0.388623099183871	no	1922	0.379843706548257	1265	NA	FT	KETONE METABOLISM|LIPID METABOLISM			Long chain fatty acyl-CoA synthetase, activates imported fatty acids; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery	long-chain fatty acid metabolic process	long-chain fatty acid-CoA ligase activity|very long-chain fatty acid-CoA ligase activity	cellular_component
YDR349C	YDR349C	YPS7	hom	Verified	0.282465808739614	0.388793180116452	no	1923	0.401636671326509	1342	NA	FT	CELL WALL ORG/BIOGENESIS|PROTEOLYSIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Putative GPI-anchored aspartic protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; located in the cytoplasm and endoplasmic reticulum	fungal-type cell wall organization	aspartic-type endopeptidase activity	endoplasmic reticulum|cytoplasm
YDR213W	YDR213W	UPC2	hom	Verified	0.281836249988548	0.389034536842165	no	1924	0.400567575740338	1307	NA	FT	TRANSCRIPTION FROM RNA POL II|LIPID METABOLISM	NUCLEUS		Sterol regulatory element binding protein; induces transcription of sterol biosynthetic genes and of DAN/TIR gene products; relocates from intracellular membranes to perinuclear foci on sterol depletion; UPC2 has a paralog, ECM22, that arose from the whole genome duplication	cellular response to hypoxia|positive regulation of ergosterol biosynthetic process by positive regulation of transcription from RNA polymerase II promoter|positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus|membrane|cytoplasm|perinuclear region of cytoplasm
YNL273W	YNL273W	TOF1	hom	Verified	0.280882984871481	0.389400075803852	no	1925	0.389194465571782	1261	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME		Subunit of a replication-pausing checkpoint complex (Tof1p-Mrc1p-Csm3p) that acts at the stalled replication fork to promote sister chromatid cohesion after DNA damage, facilitating gap repair of damaged DNA; interacts with the MCM helicase	DNA repair|DNA replication checkpoint|maintenance of DNA repeat elements|replication fork arrest|replication fork protection|DNA replication|mitotic sister chromatid cohesion	molecular_function	nuclear chromosome|replication fork protection complex|nuclear replication fork
YER078C	YER078C	ICP55	hom	Verified	0.280544601457482	0.389529855836284	no	1926	0.392254972776806	1293	NA	FT	PROTEOLYSIS	NUCLEUS|MITOCHONDRION		Mitochondrial aminopeptidase; cleaves the N termini of at least 38 imported proteins after cleavage by the mitochondrial processing peptidase (MPP), thereby increasing their stability; member of the aminopeptidase P family	protein stabilization|protein processing	aminopeptidase activity	extrinsic to mitochondrial inner membrane|mitochondrion|nucleus
YOL036W_p	YOL036W	YOL036W	hom	Uncharacterized	0.280225178198032	0.389652375394372	no	1927	0.392994356177717	1294	NA					Protein of unknown function; potential Cdc28p substrate; YOL036W has a paralog, YIR016W, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YDR534C	YDR534C	FIT1	hom	Verified	0.279008786222662	0.390119040993965	no	1928	0.341858217108166	1162	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall	siderophore transport	molecular_function	fungal-type cell wall
YIL067C_p	YIL067C	YIL067C	hom	Uncharacterized	0.278712503805419	0.390232732983485	no	1929	0.394573292502213	1335	NA					Uncharacterized protein of unknown function	biological_process	molecular_function	integral to membrane|fungal-type vacuole
YLR191W	YLR191W	PEX13	hom	Verified	0.276771176646183	0.390977907303671	no	1930	0.395653281103316	1319	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|PEROXISOME ORGANIZATION			Integral peroxisomal membrane protein required for translocation of peroxisomal matrix proteins, interacts with the PTS1 signal recognition factor Pex5p and the PTS2 signal recognition factor Pex7p, forms a complex with Pex14p and Pex17p	protein import into peroxisome matrix, docking	protein binding, bridging	peroxisomal membrane
YLR173W_p	YLR173W	YLR173W	hom	Uncharacterized	0.276701004227222	0.391004850353594	no	1931	0.395762792067699	1291	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YBR012C_d	YBR012C	YBR012C	hom	Dubious	0.274326590050295	0.391916826055622	no	1932	0.389088250153819	1271	NA					Dubious open reading frame, unlikely to encode a functional protein; expression induced by iron-regulated transcriptional activator Aft2p	Unknown	Unknown	Unknown
YGR229C	YGR229C	SMI1	hom	Verified	0.272741348275923	0.392526023951737	no	1933	0.428213478973227	1407	NA	FF|FT	CELL CYCLE|CELL WALL ORG/BIOGENESIS	NUCLEUS|SITE OF POLARIZED GROWTH		Protein involved in the regulation of cell wall synthesis; proposed to be involved in coordinating cell cycle progression with cell wall integrity	regulation of mitotic cell cycle|regulation of fungal-type cell wall biogenesis	molecular_function	incipient cellular bud site|cellular bud neck|mating projection tip
YER019C-A	YER019C-A	SBH2	hom	Verified	0.271986494833826	0.392816201800299	no	1934	0.385987279809168	1278	NA	FT	PROTEIN LOCALIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Ssh1p-Sss1p-Sbh2p complex component, involved in protein translocation into the endoplasmic reticulum; homologous to Sbh1p	SRP-dependent cotranslational protein targeting to membrane	ARF guanyl-nucleotide exchange factor activity	Ssh1 translocon complex
YLR262C-A	YLR262C-A	TMA7	hom	Verified	0.27148128488065	0.393010445954625	no	1935	0.37560276782509	1260	NA	FT	TRANSLATION	NUCLEUS		Protein of unknown that associates with ribosomes; null mutant exhibits translation defects, altered polyribosome profiles, and resistance to the translation inhibitor anisomcyin; protein abundance increases in response to DNA replication stress	cytoplasmic translation	molecular_function	nucleus|cytoplasm
YIL089W	YIL089W	YIL089W	hom	Verified	0.271360113718546	0.393057038053612	no	1936	0.379041901510173	1254	NA	FT		ENDOPLASMIC RETICULUM		Protein of unknown function found in the ER and vacuole lumen; overexpression of YIL089W affects endocytic protein trafficking	biological_process	molecular_function	fungal-type vacuole lumen|integral to membrane|endoplasmic reticulum
YCL032W	YCL032W	STE50	hom	Verified	0.269822232103292	0.393648509114913	no	1937	0.396127512547277	1288	NA	FT	CELL CYCLE|SIGNALING			Protein involved in mating response, invasive/filamentous growth, and osmotolerance, acts as an adaptor that links G protein-associated Cdc42p-Ste20p complex to the effector Ste11p to modulate signal transduction	pheromone-dependent signal transduction involved in conjugation with cellular fusion|MAPK cascade involved in osmosensory signaling pathway|osmosensory signaling pathway via Sho1 osmosensor|signal transduction involved in filamentous growth|cellular response to heat	SAM domain binding|protein kinase regulator activity	cytoplasm
YNL159C	YNL159C	ASI2	hom	Verified	0.268611509179291	0.394114327332247	no	1938	0.363676012675315	1214	NA	FT	PROTEOLYSIS	ENDOMEMBRANE SYSTEM|NUCLEUS		Integral inner nuclear membrane protein that acts with Asi1p and Asi3p to ensure the fidelity of SPS-sensor signalling by maintaining the dormant repressed state of gene expression in the absence of inducing signals	ubiquitin-dependent protein catabolic process	molecular_function	nuclear inner membrane
YMR326C_d	YMR326C	YMR326C	hom	Dubious	0.268043353793438	0.394332973903658	no	1939	0.385754407010556	1261	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the telomere on the right arm of chromosome 13	Unknown	Unknown	Unknown
YLL019C	YLL019C	KNS1	hom	Verified	0.267469188888738	0.394553966983722	no	1940	0.365615749549349	1217	NA	FT	PROTEIN PHOSPHORYLATION			Protein kinase involved in negative regulation of PolIII transcription; effector kinase of the TOR signaling pathway and phosphorylates Rpc53p to regulate ribosome and tRNA biosynthesis; member of the LAMMER family of protein kinases, which are serine/threonine kinases also capable of phosphorylating tyrosine residues; capable of autophosphorylation	negative regulation of transcription from RNA polymerase III promoter|protein autophosphorylation|protein phosphorylation	protein serine/threonine kinase activity|protein tyrosine kinase activity|protein kinase activity	nucleus|cytoplasm
YHR168W	YHR168W	MTG2	hom	Verified	0.26536869197882	0.395362725996298	no	1941	0.390663823168843	1303	NA	FT	TRANSLATION|NUCLEOTIDE METABOLISM	MITOCHONDRION		Putative GTPase, member of the Obg family; peripheral protein of the mitochondrial inner membrane that associates with the large ribosomal subunit; required for mitochondrial translation, possibly via a role in ribosome assembly	cytoplasmic translation	ribosome binding|GTPase activity	mitochondrial inner membrane|extrinsic to membrane
YEL061C	YEL061C	CIN8	hom	Verified	0.264661811681279	0.395634999270564	no	1942	0.402330366568357	1334	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION	NUCLEUS|MITOCHONDRION|CHROMOSOME|CYTOSKELETON	KINETOCHORE	Kinesin motor protein involved in mitotic spindle assembly and chromosome segregation	mitotic anaphase B|microtubule depolymerization|spindle pole body separation|mitotic spindle organization in nucleus|mitotic sister chromatid segregation	plus-end-directed microtubule motor activity|minus-end-directed microtubule motor activity	spindle microtubule|kinesin complex|mitochondrion|condensed nuclear chromosome kinetochore|kinetochore microtubule|astral microtubule
YCR077C	YCR077C	PAT1	hom	Verified	0.264303470093547	0.395773043289945	no	1943	0.405528066128949	1350	NA	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|TRANSLATION|CELL DIVISION|CHROMOSOME SEGREGATION	NUCLEUS	RIBOSOME	Deadenylation-dependent mRNA-decapping factor; also required for faithful chromosome transmission, maintenance of rDNA locus stability, and protection of mRNA 3'-UTRs from trimming; associated with topoisomerase II; functionally linked to Pab1p; forms cytoplasmic foci upon DNA replication stress	deadenylation-dependent decapping of nuclear-transcribed mRNA|chromosome segregation|regulation of translational initiation|formation of translation preinitiation complex|negative regulation of translational initiation|cytoplasmic mRNA processing body assembly	molecular_function	cytosolic small ribosomal subunit|cytoplasmic mRNA processing body
YJL147C_p	YJL147C	YJL147C	hom	Uncharacterized	0.263757740668998	0.395983299885505	no	1944	0.388779242347315	1306	NA	FT		MITOCHONDRION		Mitochondrial protein of unknown function; homozygous diploid deletion strain has a sporulation defect characterized by elevated dityrosine in the soluble fraction; expression induced by calcium shortage; YJL147W is a non-essential gene	biological_process	molecular_function	mitochondrion
YEL056W	YEL056W	HAT2	hom	Verified	0.263553488727441	0.396062001098096	no	1945	0.38265312516847	1248	NA	FT	CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING	NUCLEUS	HISTONE ACETYLTRANSFERASE	Subunit of the Hat1p-Hat2p histone acetyltransferase complex; required for high affinity binding of the complex to free histone H4, thereby enhancing Hat1p activity; similar to human RbAp46 and 48; has a role in telomeric silencing	histone acetylation|chromatin assembly or disassembly|chromatin silencing at telomere	histone acetyltransferase activity|histone binding	histone acetyltransferase complex|nucleus|cytoplasm
YMR273C	YMR273C	ZDS1	hom	Verified	0.26280101967202	0.396351974785185	no	1946	0.413338979379834	1382	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|CELL WALL ORG/BIOGENESIS|RNA LOCALIZATION|GENE SILENCING	ENDOMEMBRANE SYSTEM|NUCLEUS|SITE OF POLARIZED GROWTH	NUCLEAR PORE	Protein with a role in regulating Swe1p-dependent polarized growth; involved in maintaining Cdc55p in the cytoplasm where it promotes mitotic entry; involved in mitotic exit through Cdc14p regulation; interacts with silencing proteins at telomeres; has a role in Bcy1p localization; implicated in mRNA nuclear export; ZDS1 has a paralog, ZDS2, that arose from the whole genome duplication	mRNA export from nucleus|positive regulation of G2/M transition of mitotic cell cycle|cell shape checkpoint|chromatin silencing|establishment of cell polarity|regulation of protein localization|cell aging	protein phosphatase type 2A regulator activity	incipient cellular bud site|nuclear pore|cellular bud neck|cellular bud tip|cytoplasm
YIL069C	YIL069C	RPS24B	hom	Verified	0.261718498140329	0.396769239021414	no	1947	0.384890078623818	1263	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION	NUCLEUS	RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S24, no bacterial homolog; RPS24B has a paralog, RPS24A, that arose from the whole genome duplication	cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome	cytosolic small ribosomal subunit
YDL077C	YDL077C	VAM6	hom	Verified	0.261612361138869	0.396810156519353	no	1948	0.423588652830289	1395	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION			Vacuolar protein that plays a critical role in the tethering steps of vacuolar membrane fusion by facilitating guanine nucleotide exchange on small guanosine triphosphatase Ypt7p	regulation of SNARE complex assembly|regulation of vacuole fusion, non-autophagic|piecemeal microautophagy of nucleus|vesicle-mediated transport|vacuole organization|vacuole fusion, non-autophagic	Rab guanyl-nucleotide exchange factor activity|phosphatidylinositol binding	fungal-type vacuole membrane|HOPS complex|fungal-type vacuole
YER045C	YER045C	ACA1	hom	Verified	0.260958284798482	0.397062338384232	no	1949	0.39263877686304	1302	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		ATF/CREB family basic leucine zipper (bZIP) transcription factor; binds as a homodimer to the ATF/CREB consensus sequence TGACGTCA; important for carbon source utilization; target genes include GRE2 and COS8; ACA1 has a paralog, CST6, that arose from the whole genome duplication	positive regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YMR228W	YMR228W	MTF1	hom	Verified	0.260516140431618	0.397232833382871	no	1950	0.382244934496392	1266	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation	transcription initiation from mitochondrial promoter	mitochondrial RNA polymerase binding promoter specificity activity	mitochondrion|mitochondrial DNA-directed RNA polymerase complex|mitochondrial matrix|mitochondrial intermembrane space
YKL105C	YKL105C	SEG2	hom	Verified	0.259539324910511	0.397609572153538	no	1951	0.393690082605512	1307	NA					Eisosome component and paralog of Seg1p; likely plays only minor role in eisosome assembly; shown to interact with Seg1p; similar to A. gossypii SEG gene which is important for stabilizing eisosomes	biological_process	molecular_function	cellular_component
YOL052C-A	YOL052C-A	DDR2	hom	Verified	0.25904857945375	0.397798879214137	no	1952	0.397305007774754	1318	NA					Multi-stress response protein; expression is activated by a variety of xenobiotic agents and environmental or physiological stresses; DDR2 has a paralog, HOR7, that arose from the whole genome duplication	response to stress	molecular_function	fungal-type vacuole|cytoplasm
YOL035C_d	YOL035C	YOL035C	hom	Dubious	0.258047522420344	0.398185115620856	no	1953	0.389381274051949	1292	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YPL046C	YPL046C	ELC1	hom	Verified	0.257693558559765	0.39832170889021	no	1954	0.375365144447726	1262	NA	FT	RESPONSE TO DNA DAMAGE|PROTEOLYSIS	NUCLEUS	UBIQUITIN LIGASE COMPLEX	Elongin C, conserved among eukaryotes; forms a complex with Cul3p that polyubiquitylates monoubiquitylated RNA polymerase II to trigger its proteolysis; plays a role in global genomic repair	global genome nucleotide-excision repair|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	ubiquitin-protein ligase activity	elongin complex|Cul3-RING ubiquitin ligase complex
YML094C-A_d	YML094C-A	YML094C-A	hom	Dubious	0.257584667791866	0.39836373191849	no	1955	0.38307958035686	1295	NA	FF				Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene GIM5/YML094W; deletion confers sensitivity to GSAO	Unknown	Unknown	Unknown
YJL142C_d	YJL142C	IRC9	hom	Dubious	0.257399180184585	0.398435317844655	no	1956	0.379540436271129	1295	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene YJL141C; null mutant displays increased levels of spontaneous Rad52p foci	Unknown	Unknown	Unknown
YLR408C_p	YLR408C	BLS1	hom	Uncharacterized	0.256499725819727	0.398782496062021	no	1957	0.382678859784962	1267	NA					Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to the endosome; YLR408C is not an essential gene	biological_process	molecular_function	endosome|BLOC-1 complex
YNL173C	YNL173C	MDG1	hom	Verified	0.256252477826707	0.398877944765314	no	1958	0.411047264429291	1362	NA	FT	SIGNALING	PLASMA MEMBRANE		Plasma membrane protein involved in G-protein mediated pheromone signaling pathway; overproduction suppresses bem1 mutations	pheromone-dependent signal transduction involved in conjugation with cellular fusion	molecular_function	membrane raft|plasma membrane
YCR082W	YCR082W	AHC2	hom	Verified	0.255870693689519	0.399025342270812	no	1959	0.392851271909153	1327	NA	FT	CHROMATIN ORGANIZATION	NUCLEUS	HISTONE ACETYLTRANSFERASE	Component of the ADA histone acetyltransferase complex; Ach2p and Ach1p are unique to the ADA complex and not shared with the related SAGA and SLIK complexes; may tether Ach1p to the complex	histone acetylation	histone acetyltransferase activity	Ada2/Gcn5/Ada3 transcription activator complex|nucleus|cytoplasm
YPL003W	YPL003W	ULA1	hom	Verified	0.254695821967569	0.399479021720167	no	1960	0.402006125891796	1328	NA					Protein that acts together with Uba3p to activate Rub1p before its conjugation to proteins (neddylation), which may play a role in protein degradation	protein neddylation	NEDD8 activating enzyme activity	cellular_component
YLR206W	YLR206W	ENT2	hom	Verified	0.252969050645373	0.400146064748287	no	1961	0.37080445065216	1241	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Epsin-like protein required for endocytosis and actin patch assembly and functionally redundant with Ent1p; contains clathrin-binding motif at C-terminus	actin filament organization|endocytosis|actin cortical patch assembly	clathrin binding	mating projection tip|actin cortical patch
YLR444C_d	YLR444C	YLR444C	hom	Dubious	0.252740510665703	0.400234370465708	no	1962	0.39650120155544	1319	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YPR198W	YPR198W	SGE1	hom	Verified	0.252449222204461	0.400346929004614	no	1963	0.417993775967427	1382	NA	FF|FT		PLASMA MEMBRANE		Plasma membrane multidrug transporter of the major facilitator superfamily, acts as an extrusion permease; partial multicopy suppressor of gal11 mutations	response to drug|drug transport	drug transmembrane transporter activity	integral to membrane|integral to plasma membrane
YEL052W	YEL052W	AFG1	hom	Verified	0.251695411256685	0.400638252064369	no	1964	0.395001107520288	1322	NA	FT	PROTEIN LOCALIZATION|PROTEOLYSIS|RESPONSE TO OXIDATIVE STRESS|PEROXISOME ORGANIZATION	MITOCHONDRION		Conserved protein that may act as a chaperone in the degradation of misfolded or unassembled cytochrome c oxidase subunits; localized to matrix face of the mitochondrial inner membrane; member of the AAA family but lacks a protease domain	protein import into peroxisome matrix|cellular response to oxidative stress|misfolded or incompletely synthesized protein catabolic process	molecular_function	mitochondrion|mitochondrial inner membrane
YJR094C	YJR094C	IME1	hom	Verified	0.251428405827828	0.40074145411859	no	1965	0.385087471651263	1267	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE	NUCLEUS		Master regulator of meiosis that is active only during meiotic events, activates transcription of early meiotic genes through interaction with Ume6p, degraded by the 26S proteasome following phosphorylation by Ime2p	pseudohyphal growth|regulation of transcription from RNA polymerase II promoter|regulation of meiosis	protein binding transcription factor activity	nucleus
YNL296W_d	YNL296W	YNL296W	hom	Dubious	0.25088098250461	0.400953064025485	no	1966	0.442846848723816	1460	NA					Dubious open reading frame unlikely to encode a functional protein; deletion adversely affects sporulation; deletion mutant exhibits synthetic phenotype under expression of mutant huntingtin fragment, but gene does not have human ortholog	Unknown	Unknown	Unknown
YJL145W	YJL145W	SFH5	hom	Verified	0.248341473602897	0.401935106271466	no	1967	0.389699047115084	1287	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Non-classical phosphatidylinositol transfer protein (PITP); exhibits PI- but not PC-transfer activity; localizes to the peripheral endoplasmic reticulum, cytosol and microsomes; similar to Sec14p; partially relocalizes to the plasma membrane upon DNA replication stress	Golgi to plasma membrane protein transport|phosphatidylinositol metabolic process|Unknown|regulation of exocytosis|phospholipid transport	phosphatidylinositol transporter activity|phosphatidylcholine transporter activity	cell periphery|cytosol|plasma membrane|cortical endoplasmic reticulum
YGL216W	YGL216W	KIP3	hom	Verified	0.248007491953719	0.402064305061258	no	1968	0.378468400921616	1267	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CYTOSKELETON ORGANIZATION	NUCLEUS|CYTOSKELETON		Kinesin-related motor protein involved in mitotic spindle positioning	nuclear migration along microtubule|mitotic spindle disassembly|establishment of mitotic spindle orientation|plus-end specific microtubule depolymerization|mitotic spindle organization in nucleus	plus-end-directed microtubule motor activity|tubulin-dependent ATPase activity	kinesin complex|cytoplasmic microtubule|nuclear microtubule
YJL029C	YJL029C	VPS53	hom	Verified	0.247934034757231	0.402092722971613	no	1969	0.358711507868062	1200	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	GOLGI APPARATUS		Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; required for vacuolar protein sorting	Golgi to vacuole transport|retrograde transport, endosome to Golgi	molecular_function	Golgi apparatus|GARP complex|cytoplasm
YIR037W	YIR037W	HYR1	hom	Verified	0.247707260638539	0.402180456872365	no	1970	0.405284591295125	1334	NA	FT	OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS			Thiol peroxidase that functions as a hydroperoxide receptor to sense intracellular hydroperoxide levels and transduce a redox signal to the Yap1p transcription factor	cellular response to oxidative stress	phospholipid-hydroperoxide glutathione peroxidase activity|glutathione peroxidase activity	intracellular
YML116W	YML116W	ATR1	hom	Verified	0.247599047738584	0.402222323791955	no	1971	0.374132641537732	1245	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Multidrug efflux pump of the major facilitator superfamily; required for resistance to aminotriazole and 4-nitroquinoline-N-oxide; ATR1 has a paralog, YMR279C, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress	borate transport|drug transmembrane transport	drug transmembrane transporter activity|borate transmembrane transporter activity	integral to membrane|plasma membrane|vacuole
YNL127W	YNL127W	FAR11	hom	Verified	0.245864115673827	0.402893711413881	no	1972	0.451426339355446	1488	NA	FT	CELL CYCLE|SIGNALING			Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far8p, Far9p, and Far10p; has similarity to the N- and C-termini of N. crassa HAM-2	re-entry into mitotic cell cycle after pheromone arrest	molecular_function	cellular_component
YFL010C	YFL010C	WWM1	hom	Verified	0.245090151912093	0.403193314030335	no	1973	0.397323729765318	1325	NA	FT		NUCLEUS|MITOCHONDRION		WW domain containing protein of unknown function; binds to Mca1p, a caspase-related protease that regulates H2O2-induced apoptosis; overexpression causes G1 phase growth arrest and clonal death that is suppressed by overexpression of MCA1	biological_process	molecular_function	mitochondrion|nucleus|cytoplasm
YDL225W	YDL225W	SHS1	hom	Verified	0.243948994970834	0.403635161350274	no	1974	0.393055909639726	1322	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate with other rods to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins; undergoes sumoylation and phosphorylation during mitosis; protein abundance increases in response to DNA replication stress	cytokinesis, actomyosin contractile ring assembly|G1 phase of mitotic cell cycle|barrier septum assembly|exit from mitosis|cell cycle cytokinesis|septin ring assembly|cellular bud neck septin ring organization	GTP binding	cellular bud neck septin ring|mating projection tip
YDR046C	YDR046C	BAP3	hom	Verified	0.24379330149841	0.403695454232131	no	1975	0.382793165138329	1278	NA	FT		MITOCHONDRION|PLASMA MEMBRANE		Amino acid permease; involved in uptake of cysteine, leucine, isoleucine and valine; BAP3 has a paralog, BAP2, that arose from the whole genome duplication	amino acid transport|transmembrane transport	amino acid transmembrane transporter activity	mitochondrion|integral to membrane|plasma membrane
YAL045C_d	YAL045C	YAL045C	hom	Dubious	0.243719103043427	0.403724188667757	no	1976	0.385637628154625	1271	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps YAL044W-A	Unknown	Unknown	Unknown
YMR299C	YMR299C	DYN3	hom	Verified	0.243077480734544	0.403972687939039	no	1977	0.403958432212227	1345	NA	FT		CYTOSKELETON		Dynein light intermediate chain (LIC); localizes with dynein, null mutant is defective in nuclear migration	nuclear migration along microtubule	motor activity	cytoplasmic dynein complex|cytoplasmic microtubule
YJL148W	YJL148W	RPA34	hom	Verified	0.242200613613921	0.404312359803851	no	1978	0.343137808858262	1103	NA	FT		NUCLEUS		RNA polymerase I subunit A34.5	transcription elongation from RNA polymerase I promoter|transcription of nuclear large rRNA transcript from RNA polymerase I promoter	molecular_function	DNA-directed RNA polymerase I complex|nucleolus|nucleus
YPR116W	YPR116W	RRG8	hom	Verified	0.241949633091776	0.404409595376353	no	1979	0.394340980135517	1290	NA	FT	MITOCHONDRION ORGANIZATION	MITOCHONDRION		Putative protein of unknown function, required for mitochondrial genome maintenance; null mutation results in a decrease in plasma membrane electron transport	mitochondrial genome maintenance	molecular_function	mitochondrion
YDR260C	YDR260C	SWM1	hom	Verified	0.24131023750407	0.404657338464386	no	1980	0.408687562002942	1351	NA	FT	CELL CYCLE|CELL WALL ORG/BIOGENESIS|CELL DIVISION|PROTEOLYSIS	NUCLEUS	UBIQUITIN LIGASE COMPLEX	Subunit of the anaphase-promoting complex, which is an E3 ubiquitin ligase that regulates the metaphase-anaphase transition and exit from mitosis; required for activation of the daughter-specific gene expression and spore wall maturation	ascospore wall assembly|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|regulation of mitotic metaphase/anaphase transition|protein ubiquitination	molecular_function	anaphase-promoting complex|nucleus
YOR365C_p	YOR365C	YOR365C	hom	Uncharacterized	0.239985438702689	0.405170772512842	no	1981	0.390134474919596	1285	NA					Putative protein of unknown function; not an essential protein; YOR365C has a paralog, FLC2, that arose from the whole genome duplication	biological_process	molecular_function	integral to membrane
YDL023C_d	YDL023C	YDL023C	hom	Dubious	0.239213183484644	0.405470140222845	no	1982	0.413337453109392	1351	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in other Saccharomyces species; overlaps the verified gene GPD1; deletion confers sensitivity to GSAO; deletion in cyr1 mutant results in loss of stress resistance	Unknown	Unknown	Unknown
YMR006C	YMR006C	PLB2	hom	Verified	0.23774963869326	0.406037640593351	no	1983	0.363832322987791	1230	NA	FT	LIPID METABOLISM			Phospholipase B (lysophospholipase) involved in phospholipid metabolism; displays transacylase activity in vitro; overproduction confers resistance to lysophosphatidylcholine	glycerophospholipid metabolic process	lysophospholipase activity	extracellular region|fungal-type cell wall
YCL057C-A	YCL057C-A	MOS1	hom	Verified	0.237748331692385	0.406038147481091	no	1984	0.379798495484708	1263	NA	FT	MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial protein essential for proper inner membrane organization; conserved component of the mitochondrial inner membrane organizing system (MICOS, MINOS, or MitOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture; ortholog of human MINOS1	cristae formation	molecular_function	mitochondrion|mitochondrial crista junction|integral to mitochondrial inner membrane
YJL199C_d	YJL199C	MBB1	hom	Dubious	0.237672117202213	0.406067705645456	no	1985	0.406707996587185	1329	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; protein detected in large-scale protein-protein interaction studies	Unknown	Unknown	Unknown
YOR080W	YOR080W	DIA2	hom	Verified	0.235788397159994	0.406798436034182	no	1986	0.412329669070355	1365	NA	FT	CELL CYCLE|PROTEOLYSIS	NUCLEUS|CHROMOSOME	UBIQUITIN LIGASE COMPLEX	Origin-binding F-box protein; forms an SCF ubiquitin ligase complex with Skp1p and Cdc53p; plays a role in DNA replication; plays a role in transcription; required for correct assembly of RSC complex, correct RSC-mediated transcription regulation, and correct nucleosome positioning; involved in invasive and pseudohyphal growth; required to target Cdc6p for ubiquitin-mediated destruction during G1 phase	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|regulation of DNA replication|invasive growth in response to glucose limitation|protein ubiquitination	ubiquitin-protein ligase activity|DNA replication origin binding	SCF ubiquitin ligase complex|nucleus|nuclear replication fork
YDL160C	YDL160C	DHH1	hom	Verified	0.235629935145505	0.406859921263278	no	1987	0.421383708090399	1406	NA	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|TRANSLATION|RNA LOCALIZATION			Cytoplasmic DExD/H-box helicase, stimulates mRNA decapping; coordinates distinct steps in mRNA function and decay, interacts with both the decapping and deadenylase complexes, may have a role in mRNA export and translation; C-terminus of Dhh1p interacts with Ngr1p and promotes POR1, but not EDC1 mRNA decay; forms cytoplasmic foci upon DNA replication stress	deadenylation-dependent decapping of nuclear-transcribed mRNA|cell morphogenesis involved in conjugation with cellular fusion|stress granule assembly|cytoplasmic mRNA processing body assembly	protein binding|RNA helicase activity	cytoplasmic mRNA processing body|cytoplasmic stress granule|cytoplasm
YDR193W_d	YDR193W	YDR193W	hom	Dubious	0.23525186719689	0.40700662559169	no	1988	0.387813137146038	1308	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YPR120C	YPR120C	CLB5	hom	Verified	0.234657034411278	0.407237469091138	no	1989	0.420243932473536	1379	NA	FT	CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION	NUCLEUS		B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1 phase	spindle assembly|G1/S transition of mitotic cell cycle|regulation of S phase of mitotic cell cycle|G2/M transition of mitotic cell cycle|regulation of cyclin-dependent protein kinase activity|positive regulation of spindle pole body separation|premeiotic DNA replication|positive regulation of DNA replication	cyclin-dependent protein kinase regulator activity	nucleus
YHR131C_p	YHR131C	YHR131C	hom	Uncharacterized	0.234481561466386	0.407305573023721	no	1990	0.39808923610777	1302	NA					Putative protein of unknown function; GFP-fusion protein localizes to the cytoplasm; overexpression causes cell cycle delay or arrest; contains a PH domain and binds phosphatidylinositols and other lipids in a large-scale study	biological_process	molecular_function	cytoplasm
YGR143W	YGR143W	SKN1	hom	Verified	0.23430004629512	0.407376024992202	no	1991	0.41970282930633	1380	NA	FT	LIPID METABOLISM|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM			Protein involved in sphingolipid biosynthesis; type II membrane protein with similarity to Kre6p	fungal-type cell wall organization|(1->6)-beta-D-glucan biosynthetic process|sphingolipid biosynthetic process	glucosidase activity	integral to membrane
YNL081C	YNL081C	SWS2	hom	Verified	0.23391897545607	0.407523940780915	no	1992	0.428313562547357	1408	NA	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Putative mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S13 ribosomal protein; participates in controlling sporulation efficiency	regulation of sporulation resulting in formation of a cellular spore|mitochondrial translation	structural constituent of ribosome	mitochondrial small ribosomal subunit|cytoplasm
YOL068C	YOL068C	HST1	hom	Verified	0.233659412008983	0.407624700024137	no	1993	0.411970476993587	1371	NA	FT	CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS|CHROMOSOME		NAD(+)-dependent histone deacetylase; essential subunit of the Sum1p/Rfm1p/Hst1p complex required for ORC-dependent silencing and mitotic repression; non-essential subunit of the Set3C deacetylase complex; involved in telomere maintenance	chromatin silencing|negative regulation of mitotic recombination|histone deacetylation	NAD-independent histone deacetylase activity|NAD-dependent histone deacetylase activity	Set3 complex
YDR066C	YDR066C	RTR2	hom	Verified	0.233384004354127	0.407731616470149	no	1994	0.41214654336174	1347	NA	FT		NUCLEUS		Protein of unknown function; exhibits genetic interactions with Rtr1p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YDR066C is not an essential gene; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress; RTR2 has a paralog, RTR1, that arose from the whole genome duplication	biological_process	molecular_function	cytoplasm
YDR271C_d	YDR271C	YDR271C	hom	Dubious	0.231456018882082	0.40848027481367	no	1995	0.420394056567511	1385	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CCC2/YDR270W	Unknown	Unknown	Unknown
YJL094C	YJL094C	KHA1	hom	Verified	0.229376147476842	0.409288286770774	no	1996	0.404596746671106	1311	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION|GOLGI APPARATUS		Putative K+/H+ antiporter with a probable role in intracellular cation homeostasis, localized to Golgi vesicles and detected in highly purified mitochondria in high-throughput studies	monovalent inorganic cation transport	potassium:hydrogen antiporter activity	mitochondrion|integral to membrane|Golgi apparatus
YGL084C	YGL084C	GUP1	hom	Verified	0.229357770020992	0.409295427975946	no	1997	0.496088050737107	1663	NA	FF|FT	LIPID METABOLISM|CARBOHYDRATE METABOLISM	ENDOPLASMIC RETICULUM|PLASMA MEMBRANE		Plasma membrane protein involved in remodeling GPI anchors; member of the MBOAT family of putative membrane-bound O-acyltransferases; proposed to be involved in glycerol transport	GPI anchor biosynthetic process|glycerol transport|glycerol catabolic process	O-acyltransferase activity	integral to membrane|endoplasmic reticulum|plasma membrane|membrane
YJL144W	YJL144W	YJL144W	hom	Verified	0.22916105874192	0.409371868929281	no	1998	0.405613343548159	1325	NA					Cytoplasmic hydrophilin essential in dessication-rehydration process; expression induced by osmotic stress, starvation and during stationary phase; protein abundance increases in response to DNA replication stress	cellular response to water deprivation	molecular_function	cytoplasm
YBR264C	YBR264C	YPT10	hom	Verified	0.228991318507886	0.409437831848154	no	1999	0.411015838317302	1354	NA	FT	PROTEIN LOCALIZATION|SIGNALING	PLASMA MEMBRANE		Rab family GTP-binding protein that contains the PEST signal sequence specific for proteolytic enzymes; may be involved in vesicular transport; overexpression leads to accumulation of Golgi-like cisternae with budding vesicles	Golgi organization	GTPase activity|guanyl nucleotide binding	cytoplasm
YHR049C-A_d	YHR049C-A	YHR049C-A	hom	Dubious	0.22808060699293	0.409791788081004	no	2000	0.396097440554764	1304	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YIL043C	YIL043C	CBR1	hom	Verified	0.227706948613089	0.409937035065017	no	2001	0.416998079899174	1361	NA	FT	OXIDATION-REDUCTION PROCESS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION		Microsomal cytochrome b reductase, not essential for viability; also detected in mitochondria; mutation in conserved NADH binding domain of the human ortholog results in type I methemoglobinemia	biological_process	cytochrome-b5 reductase activity	mitochondrial outer membrane|mitochondrion
YPL005W	YPL005W	AEP3	hom	Verified	0.223763598981047	0.411470627787752	no	2002	0.388210053915578	1286	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Protein that may facilitate use of unformylated tRNA-Met in mitochondrial translation initiation; localized to the matrix face of the mitochondrial inner membrane; stabilizes the bicistronic AAP1-ATP6 mRNA	mRNA metabolic process|mitochondrial translational initiation	molecular_function	mitochondrion|mitochondrial inner membrane|cytoplasm|extrinsic to membrane
YGL244W	YGL244W	RTF1	hom	Verified	0.223472589145582	0.411583857205136	no	2003	0.434490700605766	1449	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION|GENE SILENCING	NUCLEUS|CHROMOSOME	RNA POL II, HOLOENZYME	Subunit of RNAPII-associated chromatin remodeling Paf1 complex; regulates gene expression by directing cotranscriptional histone modification, influences transcription and chromatin structure through several independent functional domains; directly or indirectly regulates DNA-binding properties of Spt15p and relative activities of different TATA elements; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay	mRNA 3'-end processing|snoRNA transcription from an RNA polymerase II promoter|regulation of chromatin silencing at telomere|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|regulation of histone H3-K4 methylation|regulation of transcription-coupled nucleotide-excision repair|negative regulation of transcription from RNA polymerase II promoter|recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex|global genome nucleotide-excision repair|snoRNA 3'-end processing|Unknown|transcription elongation from RNA polymerase II promoter	RNA binding|RNA polymerase II transcription factor binding transcription factor activity	nucleus|transcriptionally active chromatin|Cdc73/Paf1 complex
YOR357C	YOR357C	SNX3	hom	Verified	0.223127696529079	0.411718061482523	no	2004	0.411214616027777	1348	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Sorting nexin required to maintain late-Golgi resident enzymes in their proper location by recycling molecules from the prevacuolar compartment; contains a PX domain and sequence similarity to human Snx3p	protein localization|late endosome to Golgi transport	phosphatidylinositol-3-phosphate binding	cytosol|endosome
YIL010W	YIL010W	DOT5	hom	Verified	0.222004399957099	0.412155229063819	no	2005	0.385483460679806	1270	NA	FT	OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS	NUCLEUS|CHROMOSOME		Nuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase during post-diauxic growth	cellular response to oxidative stress|cell redox homeostasis	thioredoxin peroxidase activity	nucleus
YMR075W	YMR075W	RCO1	hom	Verified	0.221967359003286	0.412169646621709	no	2006	0.418760304528463	1413	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION	NUCLEUS|CHROMOSOME		Essential subunit of the histone deacetylase Rpd3S complex; interacts with Eaf3p	regulation of DNA-dependent DNA replication initiation|negative regulation of antisense RNA transcription|transcription elongation from RNA polymerase II promoter|histone deacetylation	molecular_function	Rpd3S complex|histone deacetylase complex|nucleus|Rpd3L complex
YHR096C	YHR096C	HXT5	hom	Verified	0.221183483459432	0.412474784541816	no	2007	0.431261437552344	1417	NA	FT		PLASMA MEMBRANE		Hexose transporter with moderate affinity for glucose; induced in the presence of non-fermentable carbon sources, induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs; HXT5 has a paralog, HXT3, that arose from the whole genome duplication	glucose transport|hexose transport	mannose transmembrane transporter activity|fructose transmembrane transporter activity|glucose transmembrane transporter activity	integral to membrane|plasma membrane
YPL234C	YPL234C	VMA11	hom	Verified	0.220990538058255	0.412549900196301	no	2008	0.423224051392834	1391	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Vacuolar ATPase V0 domain subunit c', involved in proton transport activity; hydrophobic integral membrane protein (proteolipid) containing four transmembrane segments; N and C termini are in the vacuolar lumen	vacuolar acidification	proton-transporting ATPase activity, rotational mechanism	vacuolar proton-transporting V-type ATPase, V0 domain|integral to membrane|fungal-type vacuole
YAL029C	YAL029C	MYO4	hom	Verified	0.220789515488886	0.412628163783322	no	2009	0.409234759647831	1362	NA	FT	RNA LOCALIZATION	MITOCHONDRION|SITE OF POLARIZED GROWTH|CYTOSKELETON		Type V myosin motor involved in actin-based transport of cargos; required for mRNA transport, including ASH1 mRNA, and facilitating the growth and movement of ER tubules into the growing bud along with She3p; MYO4 has a paralog, MYO2, that arose from the whole genome duplication	mating type switching|endoplasmic reticulum inheritance|intracellular mRNA localization	microfilament motor activity|actin filament binding	mitochondrion|filamentous actin|myosin V complex|cellular bud|cellular bud tip
YFL052W_p	YFL052W	YFL052W	hom	Uncharacterized	0.220589059235814	0.412706210346953	no	2010	0.390956769504268	1298	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Putative zinc cluster protein that contains a DNA binding domain; computational analysis suggests a role as a transcription factor; null mutant is sensitive to Calcofluor White, low osmolarity, and heat, suggesting a role for YFL052Wp in cell wall integrity	biological_process	DNA binding	cellular_component
YCL050C	YCL050C	APA1	hom	Verified	0.220309051282334	0.412815235713825	no	2011	0.419630086335621	1379	NA	FT	NUCLEOTIDE METABOLISM	NUCLEUS		AP4A phosphorylase; bifunctional diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase and ADP sulfurylase involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; catalyzes phosphorolysis of dinucleoside oligophosphates, cleaving substrates' alpha/beta-anhydride bond and introducing Pi into the beta-position of the corresponding NDP formed; protein abundance increases under DNA replication stress; APA1 has a paralog, APA2, that arose from the whole genome duplication	nucleotide biosynthetic process|nucleoside catabolic process	bis(5'-nucleosyl)-tetraphosphatase activity|sulfate adenylyltransferase (ADP) activity	nucleus|cytoplasm
YOR305W	YOR305W	RRG7	hom	Verified	0.219989553194672	0.412939645381723	no	2012	0.388652529345309	1298	NA	FT		MITOCHONDRION		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO); YOR305W is not an essential gene	biological_process	molecular_function	mitochondrion
YGR259C_d	YGR259C	YGR259C	hom	Dubious	0.219356222053725	0.413186284640164	no	2013	0.412595743554668	1359	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF TNA1/YGR260W	Unknown	Unknown	Unknown
YKR051W_p	YKR051W	YKR051W	hom	Uncharacterized	0.219341123218166	0.413192165024789	no	2014	0.416048642072502	1357	NA					Putative protein of unknown function	biological_process	molecular_function	integral to membrane
YGR202C	YGR202C	PCT1	hom	Verified	0.219142514337702	0.413269516948244	no	2015	0.38852037571408	1293	NA	FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|NUCLEUS|GOLGI APPARATUS		Cholinephosphate cytidylyltransferase; a rate-determining enzyme of the CDP-choline pathway for phosphatidylcholine synthesis, inhibited by Sec14p, activated upon lipid-binding; contains an element within the regulatory domain involved in both silencing and activation of enzymatic activity	phosphatidylcholine biosynthetic process|CDP-choline pathway	choline-phosphate cytidylyltransferase activity	nuclear envelope|Golgi apparatus|nucleus
YGL162W	YGL162W	SUT1	hom	Verified	0.2185931537969	0.413483493157933	no	2016	0.413888458163493	1364	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Transcription factor of the Zn2Cys6 family involved in sterol uptake; involved in induction of hypoxic gene expression; relocalizes from nucleus to cytoplasm upon DNA replication stress	positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II repressing transcription factor binding	nucleus
YOR337W	YOR337W	TEA1	hom	Verified	0.218305217437526	0.413595654784062	no	2017	0.401280577556827	1337	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Ty1 enhancer activator required for full levels of Ty enhancer-mediated transcription; C6 zinc cluster DNA-binding protein	transcription, DNA-dependent	sequence-specific DNA binding|DNA binding	nucleus
YJR082C	YJR082C	EAF6	hom	Verified	0.217545020947397	0.41389181266823	no	2018	0.408867968805724	1369	NA	FT	CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE	NUCLEUS	HISTONE ACETYLTRANSFERASE	Subunit of the NuA4 acetyltransferase complex that acetylates histone H4 and NuA3 acetyltransferase complex that acetylates histone H3	DNA repair|histone acetylation	histone acetyltransferase activity	nucleus|NuA4 histone acetyltransferase complex|NuA3 histone acetyltransferase complex
YHR178W	YHR178W	STB5	hom	Verified	0.21672316925175	0.414212045327621	no	2019	0.402761815725941	1323	NA	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		Transcription factor, involved in regulating multidrug resistance and oxidative stress response; forms a heterodimer with Pdr1p; contains a Zn(II)2Cys6 zinc finger domain that interacts with a pleiotropic drug resistance element in vitro	response to xenobiotic stimulus|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|transcription, DNA-dependent	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	nucleus
YMR243C	YMR243C	ZRC1	hom	Verified	0.216259121967147	0.414392885515922	no	2020	0.42002603154595	1366	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Vacuolar membrane zinc transporter; transports zinc from cytosol to vacuole for storage; also has role in resistance to zinc shock resulting from sudden influx of zinc into cytoplasm; human ortholog SLC30A10 functions as a Mn transporter and mutations in SLC30A10 cause neurotoxic accumulation of Mn in liver and brain; ZRC1 has a paralog, COT1, that arose from the whole genome duplication	cobalt ion transport|cellular zinc ion homeostasis|zinc ion transport|glutathione metabolic process	zinc ion transmembrane transporter activity|inorganic cation transmembrane transporter activity	integral to membrane|fungal-type vacuole
YOL081W	YOL081W	IRA2	hom	Verified	0.215534362063937	0.414675362246157	no	2021	0.401881862619069	1336	NA	FT	SIGNALING|NUCLEOTIDE METABOLISM	MITOCHONDRION|PLASMA MEMBRANE		GTPase-activating protein; negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions; similar to human neurofibromin; IRA2 has a paralog, IRA1, that arose from the whole genome duplication	negative regulation of cAMP biosynthetic process|negative regulation of Ras protein signal transduction|positive regulation of Ras GTPase activity|response to stress	Ras GTPase activator activity	mitochondrion|integral to membrane|cytoplasm
YNL077W	YNL077W	APJ1	hom	Verified	0.215479306418029	0.414696822107723	no	2022	0.427941321400971	1415	NA	FT		NUCLEUS|MITOCHONDRION		Chaperone with a role in SUMO-mediated protein degradation; member of the DnaJ-like family; conserved across eukaryotes; overexpression interferes with propagation of the [Psi+] prion; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; forms nuclear foci upon DNA replication stress	biological_process	unfolded protein binding	mitochondrion|nucleus|cytoplasm
YLR372W	YLR372W	SUR4	hom	Verified	0.215398639360599	0.414728265371525	no	2023	0.487359742092372	1734	NA	FF|FT	VESICLE-MEDIATED TRANSPORT|KETONE METABOLISM|LIPID METABOLISM	ENDOPLASMIC RETICULUM		Elongase, involved in fatty acid and sphingolipid biosynthesis; synthesizes very long chain 20-26-carbon fatty acids from C18-CoA primers; involved in regulation of sphingolipid biosynthesis	post-Golgi vesicle-mediated transport|fatty acid elongation|fatty acid biosynthetic process|sphingolipid biosynthetic process	fatty acid elongase activity	integral to membrane|endoplasmic reticulum
YPR053C_d	YPR053C	YPR053C	hom	Dubious	0.214876999647699	0.414931608829322	no	2024	0.405736299758716	1323	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene NHP6A/YPR052C	Unknown	Unknown	Unknown
YDR403W	YDR403W	DIT1	hom	Verified	0.213748719165897	0.41537150840799	no	2025	0.410547988446952	1357	NA	FT	CELL WALL ORG/BIOGENESIS			Sporulation-specific enzyme required for spore wall maturation, involved in the production of a soluble LL-dityrosine-containing precursor of the spore wall; transcripts accumulate at the time of prospore enclosure	ascospore wall assembly	catalytic activity	cellular_component
YDR191W	YDR191W	HST4	hom	Verified	0.213285775998326	0.415552033710686	no	2026	0.41668228198839	1392	NA	FT	KETONE METABOLISM|LIPID METABOLISM|CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS		Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst3p in silencing at telomeres, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism	short-chain fatty acid metabolic process|chromatin silencing at telomere|histone deacetylation	histone deacetylase activity|DNA binding	nucleus|cytoplasm
YLR303W	YLR303W	MET17	hom	Verified	0.213285169778415	0.415552270118639	no	2027	0.408852698471583	1341	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Methionine and cysteine synthase (O-acetyl homoserine-O-acetyl serine sulfhydrylase), required for sulfur amino acid synthesis	methionine metabolic process|cysteine biosynthetic process	O-acetylhomoserine aminocarboxypropyltransferase activity|cysteine synthase activity	plasma membrane|cytoplasm
YOR031W	YOR031W	CRS5	hom	Verified	0.2124937384534	0.415860931120092	no	2028	0.415136936388377	1338	NA					Copper-binding metallothionein, required for wild-type copper resistance	response to metal ion	copper ion binding	cytoplasm
YER010C	YER010C	YER010C	hom	Verified	0.212228471798513	0.415964397673958	no	2029	0.413024025788852	1358	NA					Protein of unknown function, forms a ring-shaped homotrimer; has similarity to members of the prokaryotic rraA family; possibly involved in a phosphotransfer reaction	biological_process	molecular_function	cellular_component
YKL084W	YKL084W	HOT13	hom	Verified	0.211210049255276	0.416361684731323	no	2030	0.411227957362347	1374	NA	FT	PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Zinc-binding mitochondrial intermembrane space (IMS) protein involved in a disulfide relay system for IMS import of cysteine-containing proteins; binds Mia40p and stimulates its Erv1p-dependent oxidation, probably by sequestering zinc	protein import into mitochondrial intermembrane space	zinc ion binding	mitochondrial intermembrane space
YDR391C_p	YDR391C	YDR391C	hom	Uncharacterized	0.210230348889529	0.416743946909351	no	2031	0.419373975279346	1382	NA	FT		NUCLEUS		Putative protein of unknown function, possibly involved in zinc homeostasis; Bdf1p-dependent transcription induced by salt stress; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus	biological_process	molecular_function	nucleus|cytoplasm
YGR068C	YGR068C	ART5	hom	Verified	0.210221595119381	0.416747362834859	no	2032	0.421632750160841	1381	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION			Protein proposed to regulate the endocytosis of plasma membrane proteins by recruiting the ubiquitin ligase Rsp5p to its target in the plasma membrane	ubiquitin-dependent endocytosis	ubiquitin protein ligase binding	cellular_component
YMR139W	YMR139W	RIM11	hom	Verified	0.20984299521524	0.416895107369373	no	2033	0.400737227988969	1317	NA	FT	PROTEOLYSIS|PROTEIN PHOSPHORYLATION			Protein kinase; required for signal transduction during entry into meiosis; promotes the formation of the Ime1p-Ume6p complex by phosphorylating Ime1p and Ume6p; shares similarity with mammalian glycogen synthase kinase 3-beta; protein abundance increases in response to DNA replication stress	proteolysis|ascospore formation|protein phosphorylation|response to stress	protein serine/threonine kinase activity|protein kinase activity	cytoplasm
YHL040C	YHL040C	ARN1	hom	Verified	0.208532213752287	0.417406716259341	no	2034	0.400707500694431	1306	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		ARN family transporter for siderophore-iron chelates; responsible for uptake of iron bound to ferrirubin, ferrirhodin, and related siderophores; protein increases in abundance and relocalizes to the vacuole upon DNA replication stress	siderophore transport	siderophore transmembrane transporter activity	endosome|integral to membrane|plasma membrane|cytoplasmic membrane-bounded vesicle
YDR300C	YDR300C	PRO1	hom	Verified	0.206465744167657	0.418213560225374	no	2035	0.421356367380153	1388	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Gamma-glutamyl kinase; catalyzes the first step in proline biosynthesis; PRO1 has a paralog, YHR033W, that arose from the whole genome duplication	proline biosynthetic process	glutamate 5-kinase activity	cytoplasm
YDR317W	YDR317W	HIM1	hom	Verified	0.206251738773843	0.41829713742234	no	2036	0.405685598223428	1345	NA	FT	RESPONSE TO DNA DAMAGE			Protein of unknown function involved in DNA repair	DNA repair	molecular_function	cellular_component
YNR049C	YNR049C	MSO1	hom	Verified	0.205996022696485	0.418397009055528	no	2037	0.416879283832519	1371	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Probable component of the secretory vesicle docking complex; acts at a late step in secretion; shows genetic and physical interactions with Sec1p; required for prospore membrane formation during sporulation; relocalizes from bud neck to nucleus upon DNA replication stress	cellular membrane fusion|ascospore-type prospore membrane assembly|vesicle docking involved in exocytosis	molecular_function	SNARE complex|cellular bud membrane|plasma membrane|prospore membrane|cellular bud neck|cellular bud tip
YHR105W	YHR105W	YPT35	hom	Verified	0.20594623409858	0.418416454939252	no	2038	0.399406711573312	1302	NA					Endosomal protein of unknown function that contains a phox (PX) homology domain and binds to both phosphatidylinositol-3-phosphate (PtdIns(3)P) and proteins involved in ER-Golgi or vesicular transport	biological_process	phosphatidylinositol-3-phosphate binding	endosome
YDR194C	YDR194C	MSS116	hom	Verified	0.20593507867946	0.418420811927672	no	2039	0.428762175142284	1394	NA	FT	RNA PROCESSING|TRANSLATION	MITOCHONDRION		DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing	RNA folding|Group I intron splicing|Group II intron splicing	RNA binding|RNA strand annealing activity|ATP-dependent RNA helicase activity	mitochondrion|mitochondrial matrix
YGR166W	YGR166W	TRS65	hom	Verified	0.205770587571184	0.418485058622942	no	2040	0.447537561432229	1486	NA	FT	VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|CELL WALL ORG/BIOGENESIS	GOLGI APPARATUS		Subunit of TRAPPII, a multimeric guanine nucleotide-exchange factor for Ypt1p; involved in intra-Golgi traffic and the retrograde pathway from the endosome to Golgi; role in cell wall beta-glucan biosynthesis and the stress response	intra-Golgi vesicle-mediated transport|protein complex assembly	Rab guanyl-nucleotide exchange factor activity	TRAPP complex|trans-Golgi network
YHR171W	YHR171W	ATG7	hom	Verified	0.205139450223144	0.418731587485132	no	2041	0.453684589113728	1491	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS	MITOCHONDRION		Autophagy-related protein and dual specificity member of the E1 family of ubiquitin-activating enzymes; mediates the conjugation of Atg12p with Atg5p and Atg8p with phosphatidylethanolamine, required steps in autophagosome formation	C-terminal protein lipidation|protein modification by small protein conjugation|piecemeal microautophagy of nucleus|mitochondrion degradation|macroautophagy|CVT pathway	APG8 activating enzyme activity|APG12 activating enzyme activity	cytosol|mitochondrion|membrane|pre-autophagosomal structure
YLR068W	YLR068W	FYV7	hom	Verified	0.204778126743602	0.418872738596934	no	2042	0.426884179373812	1406	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Essential protein required for maturation of 18S rRNA; required for survival upon exposure to K1 killer toxin	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	molecular_function	nucleolus|nucleus
YER106W	YER106W	MAM1	hom	Verified	0.204479269186787	0.418989495272415	no	2043	0.414658021058041	1388	NA	FT	CELL CYCLE|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME	KINETOCHORE	Monopolin, kinetochore associated protein involved in chromosome attachment to meiotic spindle	meiotic chromosome segregation|meiotic sister chromatid cohesion involved in meiosis I	molecular_function	condensed nuclear chromosome kinetochore|monopolin complex
YNL179C_d	YNL179C	YNL179C	hom	Dubious	0.204398219168999	0.419021160853921	no	2044	0.418424451147937	1390	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; deletion in cyr1 mutant results in loss of stress resistance	Unknown	Unknown	Unknown
YBR222C	YBR222C	PCS60	hom	Verified	0.204013641010298	0.419171419553412	no	2045	0.400603917798235	1305	NA					Peroxisomal protein that binds AMP and mRNA, localizes to both the peroxisomal peripheral membrane and matrix, expression is highly inducible by oleic acid, similar to E. coli long chain acyl-CoA synthetase	biological_process	mRNA binding|AMP binding	integral to membrane|peroxisomal matrix|peroxisomal membrane|cytoplasm
YPL152W-A_p	YPL152W-A	YPL152W-A	hom	Uncharacterized	0.203095516361656	0.419530188064327	no	2046	0.417581665269737	1398	NA					Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching	biological_process	molecular_function	cellular_component
YJR054W	YJR054W	KCH1	hom	Verified	0.202717132429708	0.419678065729602	no	2047	0.415518336613571	1349	NA					Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate	biological_process	molecular_function	integral to membrane|fungal-type vacuole
YPR199C	YPR199C	ARR1	hom	Verified	0.202333572800799	0.419827977705797	no	2048	0.418009293204282	1345	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Transcriptional activator of the basic leucine zipper (bZIP) family, required for transcription of genes involved in resistance to arsenic compounds	positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance	RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus|cytoplasm
YOR307C	YOR307C	SLY41	hom	Verified	0.201239416443044	0.420255686005297	no	2049	0.4342813388891	1429	NA	FT	VESICLE-MEDIATED TRANSPORT	ENDOPLASMIC RETICULUM		Protein involved in ER-to-Golgi transport	ER to Golgi vesicle-mediated transport	molecular_function	integral to membrane|endoplasmic reticulum
YKR101W	YKR101W	SIR1	hom	Verified	0.200090415384563	0.420704934605062	no	2050	0.392174696644978	1294	NA	FT	CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS|CHROMOSOME		Protein involved in repression of transcription at the silent mating-type loci HML and HMR; recruitment to silent chromatin requires interactions with Orc1p and with Sir4p, through a common Sir1p domain; binds to centromeric chromatin	establishment of chromatin silencing|chromatin silencing at silent mating-type cassette	chromatin binding|sequence-specific DNA binding	chromatin silencing complex
YFR009W	YFR009W	GCN20	hom	Verified	0.199183776384307	0.421059494860522	no	2051	0.436611497270357	1439	NA	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|NUCLEOTIDE METABOLISM		RIBOSOME	Positive regulator of the Gcn2p kinase activity, forms a complex with Gcn1p; proposed to stimulate Gcn2p activation by an uncharged tRNA	regulation of translational elongation	ATPase activity	cytosol|cytosolic ribosome
YDR194W-A_p	YDR194W-A	YDR194W-A	hom	Uncharacterized	0.198072516053693	0.421494163907644	no	2052	0.454118232661236	1500	NA					Putative protein of unknown function; identified by fungal homology and RT-PCR	biological_process	molecular_function	cellular_component
YKL138C	YKL138C	MRPL31	hom	Verified	0.198030618784671	0.4215105538832	no	2053	0.413101934894311	1366	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation	structural constituent of ribosome	mitochondrial large ribosomal subunit
YFL041W-A_p	YFL041W-A	YFL041W-A	hom	Uncharacterized	0.197976571838487	0.421531696944854	no	2054	0.41680834002783	1355	NA					Putative protein of unknown function; identified by fungal homology and RT-PCR	biological_process	molecular_function	cellular_component
YKL005C	YKL005C	BYE1	hom	Verified	0.197359155722425	0.421773244984245	no	2055	0.421388685829681	1371	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Negative regulator of transcription elongation, contains a TFIIS-like domain and a PHD finger, multicopy suppressor of temperature-sensitive ess1 mutations, probably binds RNA polymerase II large subunit	negative regulation of transcription from RNA polymerase II promoter	methylated histone residue binding	nucleus
YHR205W	YHR205W	SCH9	hom	Verified	0.196296420467248	0.422189081472288	no	2056	0.403793419463429	1323	NA	FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|RIBOSOME BIOGENESIS|PROTEIN PHOSPHORYLATION|RESPONSE TO OXIDATIVE STRESS	NUCLEUS|CHROMOSOME		AGC family protein kinase; functional ortholog of mammalian S6 kinase; phosphorylated by Tor1p and required for TORC1-mediated regulation of ribosome biogenesis, translation initiation, and entry into G0 phase; involved in transactivation of osmostress-responsive genes; regulates G1 progression, cAPK activity and nitrogen activation of the FGM pathway; integrates nutrient signals and stress signals from sphingolipids to regulate lifespan	protein phosphorylation|age-dependent response to oxidative stress involved in chronological cell aging|replicative cell aging|regulation of protein localization|positive regulation of transcription from RNA polymerase III promoter|positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase I promoter|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|regulation of cell size|regulation of response to osmotic stress	protein serine/threonine kinase activity	chromatin|fungal-type vacuole membrane|nucleus|cytoplasm
YLR401C	YLR401C	DUS3	hom	Verified	0.19561295514938	0.422456559718686	no	2057	0.382291363549335	1240	NA	FT	RNA PROCESSING|OXIDATION-REDUCTION PROCESS	NUCLEUS		Dihydrouridine synthase; member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus4p; contains a consensus oleate response element (ORE) in its promoter region; forms nuclear foci upon DNA replication stress	tRNA modification	tRNA dihydrouridine synthase activity	nucleus|cytoplasm
YKL107W_p	YKL107W	YKL107W	hom	Uncharacterized	0.195507252734224	0.42249793018826	no	2058	0.412788832841483	1363	NA	FT	OXIDATION-REDUCTION PROCESS			Putative short-chain dehydrogenase/reductase; proposed to be a palmitoylated membrane protein	biological_process	molecular_function	cellular_component
YDR329C	YDR329C	PEX3	hom	Verified	0.195283786449148	0.42258539462847	no	2059	0.427876148459949	1393	NA	FT	PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION	ENDOPLASMIC RETICULUM		Peroxisomal membrane protein (PMP) required for proper localization and stability of PMPs; anchors peroxisome retention factor Inp1p at the peroxisomal membrane; interacts with Pex19p	protein import into peroxisome membrane|peroxisome inheritance|ER-dependent peroxisome organization	protein binding	peroxisomal membrane|endoplasmic reticulum
YBL046W	YBL046W	PSY4	hom	Verified	0.194399292016329	0.422931622117638	no	2060	0.420804436854817	1391	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS		Regulatory subunit of protein phosphatase PP4; presence of Psy4p in the PP4 complex (along with catalytic subunit Pph3p and Psy2p) is required for dephosphorylation of the histone variant H2AX, but not for dephosphorylation of Rad53p, during recovery from the DNA damage checkpoint; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; required for cisplatin resistance; homolog of mammalian R2	Unknown|protein dephosphorylation	protein phosphatase regulator activity	nucleus|cytoplasm
YDL160C-A	YDL160C-A	MHF2	hom	Verified	0.193769091714267	0.423178344765541	no	2061	0.430591126115627	1419	NA	FT	RESPONSE TO DNA DAMAGE			Component of the heterotetrameric MHF histone-fold complex; in humans the MMF complex interacts with both DNA and Mph1p ortholog FANCM to stabilize and remodel blocked replication forks and repair damaged DNA; mhf2 srs2 double mutants are MMS hypersensitive; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-X, also known as MHF2	response to DNA damage stimulus	molecular_function	cellular_component
YOR112W	YOR112W	CEX1	hom	Verified	0.192848234867251	0.423538913248465	no	2062	0.427100447740741	1422	NA	FT	RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS		Cytoplasmic component of the nuclear aminoacylation-dependent tRNA export pathway; interacts with nuclear pore component Nup116p; copurifies with tRNA export receptors Los1p and Msn5p, as well as eIF-1a and the RAN GTPase Gsp1p	tRNA export from nucleus	tRNA binding	nuclear pore|cytoplasm
YJR119C	YJR119C	JHD2	hom	Verified	0.192753869469679	0.423575866357975	no	2063	0.393303518571584	1296	NA	FT	CHROMATIN ORGANIZATION|OXIDATION-REDUCTION PROCESS	NUCLEUS		JmjC domain family histone demethylase specific for H3-K4 (histone H3 Lys4); removes methyl groups specifically added by Set1p methyltransferase; protein levels regulated by Not4p (E3 ubiquitin ligase) polyubiquitin-mediated degradation	histone demethylation	histone demethylase activity (H3-K4 specific)	nucleus|cytoplasm
YGR167W	YGR167W	CLC1	hom	Verified	0.192401272413277	0.42371394789008	no	2064	0.437173856755598	1439	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS|PLASMA MEMBRANE		Clathrin light chain; subunit of the major coat protein involved in intracellular protein transport and endocytosis; thought to regulate clathrin function; two Clathrin heavy chains (CHC1) form the clathrin triskelion structural component; YGR167W	endocytosis|vesicle-mediated transport	structural molecule activity	clathrin vesicle coat
YOL129W	YOL129W	VPS68	hom	Verified	0.192159843117991	0.423808500104466	no	2065	0.427897936012195	1415	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	MITOCHONDRION		Vacuolar membrane protein of unknown function involved in vacuolar protein sorting; also detected in the mitochondria	late endosome to vacuole transport via multivesicular body sorting pathway|protein targeting to vacuole	molecular_function	Vps55/Vps68 complex|mitochondrion|fungal-type vacuole membrane|integral to membrane
YDR521W_d	YDR521W	YDR521W	hom	Dubious	0.187916210300982	0.425471167564996	no	2066	0.412189110001367	1346	NA					Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol	Unknown	Unknown	Unknown
YDR242W	YDR242W	AMD2	hom	Verified	0.186981378965361	0.425837616444867	no	2067	0.386678808663754	1242	NA					Putative amidase	biological_process	amidase activity	cellular_component
YNL120C_d	YNL120C	YNL120C	hom	Dubious	0.185556568349461	0.4263962576985	no	2068	0.422026747363393	1409	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; deletion enhances replication of Brome mosaic virus in S. cerevisiae, but likely due to effects on the overlapping gene	Unknown	Unknown	Unknown
YNL115C_p	YNL115C	YNL115C	hom	Uncharacterized	0.184765287686992	0.426706567724504	no	2069	0.42263283300748	1389	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL115C is not an essential gene	biological_process	molecular_function	integral to membrane|fungal-type vacuole
YJR069C	YJR069C	HAM1	hom	Verified	0.184723908966611	0.426722796126741	no	2070	0.417516732378884	1371	NA	FT	NUCLEOTIDE METABOLISM	NUCLEUS		Nucleoside triphosphate pyrophosphohydrolase; active against a wide range of substrates including ITP, dITP and XTP; mediates exclusion of noncanonical purines and pyrimadines from deoxyribonucleoside triphosphate pools; mutant is sensitive to the base analog 6-N-hydroxylaminopurine; protein abundance increases in response to DNA replication stress	purine deoxyribonucleoside triphosphate catabolic process|pyrimidine deoxyribonucleoside triphosphate catabolic process	dITP diphosphatase activity|ITP diphosphatase activity|XTP diphosphatase activity|dCTP diphosphatase activity|UTP diphosphatase activity|dTTP diphosphatase activity|dATP pyrophosphohydrolase activity|dGTP diphosphatase activity|dUTP diphosphatase activity|GTP diphosphatase activity	nucleus|cytoplasm
YDR122W	YDR122W	KIN1	hom	Verified	0.184390496006231	0.426853562539748	no	2071	0.406160120021211	1352	NA	FT	VESICLE-MEDIATED TRANSPORT|PROTEIN PHOSPHORYLATION	PLASMA MEMBRANE		Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p	protein autophosphorylation|exocytosis|protein phosphorylation	protein serine/threonine kinase activity|protein kinase activity	internal side of plasma membrane|plasma membrane
YML101C	YML101C	CUE4	hom	Verified	0.183845028147295	0.427067515389573	no	2072	0.372681362061078	1231	NA	FT		ENDOPLASMIC RETICULUM		Protein of unknown function; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination; CUE4 has a paralog, CUE1, that arose from the whole genome duplication	biological_process	molecular_function	endoplasmic reticulum|cytoplasm
YPR135W	YPR135W	CTF4	hom	Verified	0.183834917834682	0.427071481234198	no	2073	0.49927886553235	1674	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME		Chromatin-associated protein, required for sister chromatid cohesion; interacts with DNA polymerase alpha (Pol1p) and may link DNA synthesis to sister chromatid cohesion	DNA repair|replicative cell aging|double-strand break repair via break-induced replication|DNA replication initiation|DNA-dependent DNA replication|mitotic sister chromatid cohesion	chromatin binding|DNA binding	nuclear chromosome|replication fork protection complex|nuclear replication fork|nucleus
YOR333C_d	YOR333C	YOR333C	hom	Dubious	0.183748272873048	0.427105468661111	no	2074	0.421979242600178	1394	NA					Dubious open reading frame, unlikely to encode a functional protein; overlaps 5' end of MRS2 gene required for respiratory growth	Unknown	Unknown	Unknown
YOR308C	YOR308C	SNU66	hom	Verified	0.183543875490007	0.427185647897218	no	2075	0.425334096645131	1386	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Component of the U4/U6.U5 snRNP complex involved in pre-mRNA splicing via spliceosome; also required for pre-5S rRNA processing and may act in concert with Rnh70p; has homology to human SART-1	maturation of 5S rRNA|mRNA splicing, via spliceosome	molecular_function	U4/U6 x U5 tri-snRNP complex
YJL048C	YJL048C	UBX6	hom	Verified	0.181835659557421	0.427855849364272	no	2076	0.423578135239225	1401	NA	FT	PROTEOLYSIS	NUCLEUS		UBX (ubiquitin regulatory X) domain-containing protein; interacts with Cdc48p, transcription is repressed when cells are grown in media containing inositol and choline; UBX6 has a paralog, UBX7, that arose from the whole genome duplication	sporulation resulting in formation of a cellular spore|ubiquitin-dependent protein catabolic process	molecular_function	nucleus
YGL088W_d	YGL088W	YGL088W	hom	Dubious	0.181710100130358	0.427905119589367	no	2077	0.419795498511277	1384	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps snR10, a snoRNA required for preRNA processing	Unknown	Unknown	Unknown
YBR005W	YBR005W	RCR1	hom	Verified	0.176381397692556	0.429997159021358	no	2078	0.414404852986599	1345	NA	FT	VESICLE-MEDIATED TRANSPORT|CELL WALL ORG/BIOGENESIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein of the ER membrane involved in cell wall chitin deposition; may function in the endosomal-vacuolar trafficking pathway, helping determine whether plasma membrane proteins are degraded or routed to the plasma membrane; RCR1 has a paralog, RCR2, that arose from the whole genome duplication	fungal-type cell wall organization|vesicle-mediated transport	molecular_function	integral to endoplasmic reticulum membrane
YDL025C	YDL025C	RTK1	hom	Verified	0.175796792760856	0.430226794702246	no	2079	0.454305978671703	1513	NA	FT	PROTEIN PHOSPHORYLATION			Putative protein kinase, potentially phosphorylated by Cdc28p; interacts with ribosome biogenesis factors, Cka2, Gus1 and Arc1; protein abundance increases in response to DNA replication stress	biological_process	protein serine/threonine kinase activity|protein kinase activity	cellular_component
YPL015C	YPL015C	HST2	hom	Verified	0.17495315730644	0.430558220425639	no	2080	0.434703190213054	1409	NA	FT	GENE SILENCING	NUCLEUS		Cytoplasmic member of the silencing information regulator 2 (Sir2) family of NAD(+)-dependent protein deacetylases; modulates nucleolar (rDNA) and telomeric silencing; possesses NAD(+)-dependent histone deacetylase activity in vitro; contains a nuclear export signal (NES); function regulated by its nuclear export	negative regulation of chromatin silencing at telomere|chronological cell aging|chromatin silencing at rDNA|negative regulation of mitotic recombination	NAD-dependent histone deacetylase activity	cytoplasm
YNR036C	YNR036C	MRPS12	hom	Verified	0.174191739537927	0.43085738859476	no	2081	0.437161338290931	1457	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial protein; may interact with ribosomes based on co-purification experiments; similar to E. coli and human mitochondrial S12 ribosomal proteins	mitochondrial translation	structural constituent of ribosome	mitochondrion|ribosome|mitochondrial small ribosomal subunit
YPR119W	YPR119W	CLB2	hom	Verified	0.173767497417993	0.431024094520346	no	2082	0.43703535941755	1453	NA	FT	CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION	NUCLEUS|SITE OF POLARIZED GROWTH|CYTOSKELETON		B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome	G2/M transition of mitotic cell cycle|regulation of cyclin-dependent protein kinase activity|positive regulation of spindle pole body separation	cyclin-dependent protein kinase regulator activity	nucleus|spindle pole body|cellular bud neck|spindle|cytoplasm
YHR176W	YHR176W	FMO1	hom	Verified	0.173715213204379	0.431044640451418	no	2083	0.434710604359182	1428	NA	FT	OXIDATION-REDUCTION PROCESS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Flavin-containing monooxygenase, localized to the cytoplasmic face of the ER membrane; catalyzes oxidation of biological thiols to maintain the ER redox buffer ratio for correct folding of disulfide-bonded proteins	protein folding	N,N-dimethylaniline monooxygenase activity	endoplasmic reticulum membrane
YOR297C	YOR297C	TIM18	hom	Verified	0.173308907104473	0.431204311389234	no	2084	0.423987046599663	1393	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS	MITOCHONDRION		Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; may mediate assembly or stability of the complex	cellular response to oxidative stress|protein import into mitochondrial inner membrane|apoptotic process|response to acid|response to osmotic stress|response to arsenic-containing substance	protein channel activity	mitochondrion|integral to membrane|mitochondrial inner membrane protein insertion complex
YBR023C	YBR023C	CHS3	hom	Verified	0.173117176541606	0.431279661933969	no	2085	0.457651312239692	1529	NA	FT	CELL WALL ORG/BIOGENESIS|CELL DIVISION|CARBOHYDRATE METABOLISM	SITE OF POLARIZED GROWTH		Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan	ascospore wall assembly|fungal-type cell wall chitin biosynthetic process|cytokinesis	chitin synthase activity	incipient cellular bud site|integral to membrane|chitosome|prospore membrane|cellular bud neck|mating projection tip|cytoplasm
YER050C	YER050C	RSM18	hom	Verified	0.17220622716943	0.431637701221977	no	2086	0.429053046181595	1427	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YJR115W_p	YJR115W	YJR115W	hom	Uncharacterized	0.171125257625326	0.432062638042131	no	2087	0.417760782359225	1376	NA					Putative protein of unknown function; YJR115W has a paralog, ECM13, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YLR061W	YLR061W	RPL22A	hom	Verified	0.170984640696954	0.432117921345862	no	2088	0.412293732008976	1350	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L22A; required for the oxidative stress response in yeast; homologous to mammalian ribosomal protein L22, no bacterial homolog; RPL22A has a paralog, RPL22B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YJR058C	YJR058C	APS2	hom	Verified	0.17036434141312	0.43236180679339	no	2089	0.410498020574042	1331	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|PLASMA MEMBRANE		Small subunit of the clathrin-associated adaptor complex AP-2, which is involved in protein sorting at the plasma membrane; related to the sigma subunit of the mammalian plasma membrane clathrin-associated protein (AP-2) complex	vesicle-mediated transport	molecular_function	AP-2 adaptor complex
YER110C	YER110C	KAP123	hom	Verified	0.170315051764829	0.432381187299976	no	2090	0.395644420339049	1342	NA	FT	PROTEIN LOCALIZATION|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	Karyopherin beta, mediates nuclear import of ribosomal proteins prior to assembly into ribosomes and import of histones H3 and H4; localizes to the nuclear pore, nucleus, and cytoplasm; exhibits genetic interactions with RAI1	NLS-bearing substrate import into nucleus|Unknown|protein import into nucleus|ribosomal protein import into nucleus	protein transporter activity|nuclear localization sequence binding	integral to membrane|nucleus|nuclear pore|cytoplasm
YLL015W	YLL015W	BPT1	hom	Verified	0.170239995318545	0.432410699528292	no	2091	0.392259383891257	1292	NA	FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS			ABC type transmembrane transporter of MRP/CFTR family, found in vacuolar membrane, involved in the transport of unconjugated bilirubin and in heavy metal detoxification via glutathione conjugates, along with Ycf1p	cadmium ion transport|bilirubin transport	bilirubin transmembrane transporter activity|cadmium ion transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane
YIL112W	YIL112W	HOS4	hom	Verified	0.16925043601892	0.43279982988713	no	2092	0.423346028335356	1391	NA	FT	CELL CYCLE|CHROMATIN ORGANIZATION	NUCLEUS|CHROMOSOME		Subunit of the Set3 complex, which is a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity; potential Cdc28p substrate	negative regulation of meiosis|histone deacetylation	molecular_function	Set3 complex
YOR263C_d	YOR263C	YOR263C	hom	Dubious	0.168418636214874	0.433126973965412	no	2093	0.430967832216529	1441	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF DES3/YOR264W	Unknown	Unknown	Unknown
YDL079C	YDL079C	MRK1	hom	Verified	0.167803941719502	0.433368760715006	no	2094	0.433734368870482	1420	NA	FT	PROTEIN PHOSPHORYLATION			Glycogen synthase kinase 3 (GSK-3) homolog; one of four GSK-3 homologs in S. cerevisiae that function to activate Msn2p-dependent transcription of stress responsive genes and that function in protein degradation	regulation of protein catabolic process|protein phosphorylation|response to stress	protein serine/threonine kinase activity	cellular_component
YPL013C	YPL013C	MRPS16	hom	Verified	0.167545248209134	0.433470523867877	no	2095	0.444187864946196	1461	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the small subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YPR196W_p	YPR196W	YPR196W	hom	Uncharacterized	0.166929720827748	0.433712673704555	no	2096	0.426980664715301	1420	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Putative maltose-responsive transcription factor	regulation of transcription, DNA-dependent	sequence-specific DNA binding	cellular_component
YOL006C	YOL006C	TOP1	hom	Verified	0.165641670132341	0.434219476112139	no	2097	0.41829620495631	1365	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|CHROMOSOME SEGREGATION|GENE SILENCING	NUCLEUS|CHROMOSOME		Topoisomerase I, nuclear enzyme that relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone; relaxes both positively and negatively supercoiled DNA; functions in replication, transcription, and recombination	nuclear migration|chromatin assembly or disassembly|DNA topological change|DNA strand elongation involved in DNA replication|regulation of mitotic recombination|chromatin silencing at rDNA|regulation of transcription from RNA polymerase II promoter|mitotic chromosome condensation|transcription elongation from RNA polymerase II promoter	DNA topoisomerase type I activity	replication fork protection complex|nucleolus|nucleus
YJL071W	YJL071W	ARG2	hom	Verified	0.1654714195029	0.43428647182452	no	2098	0.427696748104237	1418	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		Acetylglutamate synthase (glutamate N-acetyltransferase), mitochondrial enzyme that catalyzes the first step in the biosynthesis of the arginine precursor ornithine; forms a complex with Arg5,6p	arginine biosynthetic process|ornithine biosynthetic process	acetyl-CoA:L-glutamate N-acetyltransferase activity	mitochondrial matrix
YHR079C-A	YHR079C-A	SAE3	hom	Verified	0.16503154981718	0.434459574677995	no	2099	0.42700356124132	1422	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Meiosis specific protein involved in DMC1-dependent meiotic recombination, forms heterodimer with Mei5p; proposed to be an assembly factor for Dmc1p	double-strand break repair|reciprocal meiotic recombination|meiotic DNA recombinase assembly	molecular_function	condensed nuclear chromosome
YPL202C	YPL202C	AFT2	hom	Verified	0.164525975877063	0.434658549786717	no	2100	0.392703629505885	1284	NA	FT	TRANSCRIPTION FROM RNA POL II|ION HOMEOSTASIS|ION HOMEOSTASIS|RESPONSE TO NUTRIENT LEVELS|RESPONSE TO OXIDATIVE STRESS	NUCLEUS|MITOCHONDRION		Iron-regulated transcriptional activator; activates genes involved in intracellular iron use and required for iron homeostasis and resistance to oxidative stress; AFT2 has a paralog, AFT1, that arose from the whole genome duplication	cellular response to oxidative stress|cellular iron ion homeostasis|positive regulation of transcription from RNA polymerase II promoter in response to iron ion starvation|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	mitochondrion|nucleus
YER187W_p	YER187W	YER187W	hom	Uncharacterized	0.164136252741966	0.434811941624697	no	2101	0.425924558252115	1413	NA					Putative protein of unknown function; induced in respiratory-deficient cells	biological_process	molecular_function	cellul