strainid orf gene zyg qualifier SGTC_3158|9100007.score SGTC_3158|9100007.expt.zyg.pval SGTC_3158|9100007.expt.zyg.significant SGTC_3158|9100007.expt.zyg.rank strain.pval strain.rank clearance Fclass Fterms.BP Fterms.CC Fterms.complex description GO_process GO_function GO_component
YMR052W YMR052W FAR3 hom Verified 11.2769590378479 8.52698182088454e-30 yes 1 1.67779176537752e-26 2 NA FT CELL CYCLE|SIGNALING ENDOPLASMIC RETICULUM Protein of unknown function; involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far7p, Far8p, Far9p, Far10p, and Far11p; localizes to the endoplasmic reticulum; protein abundance increases in response to DNA replication stress re-entry into mitotic cell cycle after pheromone arrest molecular_function endoplasmic reticulum
YDL068W_d YDL068W YDL068W hom Dubious 6.57685866726002 2.4024554398248e-11 yes 2 1.51602281647423e-09 9 NA Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YKL029C YKL029C MAE1 hom Verified 6.0582147815975 6.88202678283271e-10 yes 3 3.20751639111218e-10 3 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS MITOCHONDRION Mitochondrial malic enzyme, catalyzes the oxidative decarboxylation of malate to pyruvate, which is a key intermediate in sugar metabolism and a precursor for synthesis of several amino acids pyruvate metabolic process|cellular amino acid metabolic process malic enzyme activity mitochondrion
YAL022C YAL022C FUN26 hom Verified 5.92062255181634 1.60362595325757e-09 yes 4 1.42273778738625e-09 2 NA Vacuolar membrane transporter with broad nucleoside selectivity; may regulate balance of nicotinamide riboside (NmR) levels between cytosol and vacuole, contributing to salvage of NmR for use in cytosolic NAD+ synthesis nucleoside transport|nicotinamide riboside transport|transmembrane transport nicotinamide riboside transporter activity|nucleoside transmembrane transporter activity fungal-type vacuole membrane|integral to membrane|intracellular|membrane
YFL001W YFL001W DEG1 hom Verified 5.75819317679638 4.25095143921905e-09 yes 5 1.45366336022075e-07 5 NA FT RNA PROCESSING NUCLEUS tRNA:pseudouridine synthase, introduces pseudouridines at position 38 or 39 in tRNA, important for maintenance of translation efficiency and normal cell growth, localizes to both the nucleus and cytoplasm; non-essential for viability tRNA pseudouridine synthesis pseudouridine synthase activity nucleus|cytoplasm
YPR123C_d YPR123C YPR123C hom Dubious 5.61401605850014 9.88419283367637e-09 yes 6 7.45370601458153e-05 46 NA FF Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially/completely overlaps the verified ORF CTR Unknown Unknown Unknown
YKL142W YKL142W MRP8 hom Verified 5.11578938892327 1.56215762840161e-07 yes 7 3.05772019999237e-07 3 NA Protein of unknown function; undergoes sumoylation; transcription induced under cell wall stress; protein levels are reduced under anaerobic conditions; protein abundance increases in response to DNA replication stress; originally thought to be a mitochondrial ribosomal protein based on sequence analysis biological_process molecular_function cytoplasm
YDR359C YDR359C EAF1 hom Verified 5.04954374073114 2.21433264219235e-07 yes 8 5.48720725598124e-07 11 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE NUCLEUS HISTONE ACETYLTRANSFERASE Component of the NuA4 histone acetyltransferase complex; acts as a platform for assembly of NuA4 subunits into the native complex; required for initiation of pre-meiotic DNA replication, likely due to its requirement for expression of IME1 DNA repair|cellular protein complex assembly|chromatin modification molecular_function histone acetyltransferase complex|NuA4 histone acetyltransferase complex
YDL162C_d YDL162C YDL162C hom Dubious 4.7532595064959 1.0008158162462e-06 yes 9 3.98335998265192e-07 2 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps ENT1/YDL161W, a verified gene involved in endocytosis and actin cortical patch assembly Unknown Unknown Unknown
YPL163C YPL163C SVS1 hom Verified 4.69407065406393 1.33910731832136e-06 yes 10 1.85268568126456e-07 3 NA Cell wall and vacuolar protein; required for wild-type resistance to vanadate; SVS1 has a paralog, SRL1, that arose from the whole genome duplication response to chemical stimulus molecular_function fungal-type cell wall|fungal-type vacuole
YGL071W YGL071W AFT1 hom Verified 4.43933141106846 4.51193847714918e-06 yes 11 0.00318019024496372 83 NA FF|FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|ION HOMEOSTASIS|ION HOMEOSTASIS|RESPONSE TO NUTRIENT LEVELS|CHROMOSOME SEGREGATION NUCLEUS Transcription factor involved in iron utilization and homeostasis; binds consensus site PyPuCACCCPu and activates transcription in response to changes in iron availability; in iron-replete conditions activity is negatively regulated by Grx3p, Grx4p, and Fra2p, which regulate Aft1p translocation from the nucleus to the cytoplasm; AFT1 has a paralog, AFT2, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress positive regulation of transcription from RNA polymerase II promoter in response to iron ion starvation|meiotic chromosome segregation|positive regulation of iron ion transport|establishment of mitotic sister chromatid cohesion|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity|core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding nucleus|cytoplasm
YBL106C YBL106C SRO77 hom Verified 4.3992421255893 5.43147871953765e-06 yes 12 2.44561852704983e-05 36 NA FF|FT VESICLE-MEDIATED TRANSPORT PLASMA MEMBRANE Protein with roles in exocytosis and cation homeostasis; functions in docking and fusion of post-Golgi vesicles with plasma membrane; homolog of Drosophila lethal giant larvae tumor suppressor; interacts with SNARE protein Sec9p; SRO77 has a paralog, SRO7, that arose from the whole genome duplication exocytosis|Golgi to plasma membrane transport molecular_function plasma membrane
YER164W YER164W CHD1 hom Verified 4.26228850758489 1.01171984833247e-05 yes 13 4.85247034507024e-05 16 NA FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|CHROMATIN ORGANIZATION NUCLEUS|MITOCHONDRION|CHROMOSOME HISTONE ACETYLTRANSFERASE Chromatin remodeler that regulates various aspects of transcription; acts in in conjunction with Isw1b to regulate chromatin structure and maintain chromatin integrity during transcription elongation by RNAP II by preventing trans-histone exchange over coding regions; contains a chromo domain, a helicase domain and a DNA-binding domain; component of both the SAGA and SLIK complexes termination of RNA polymerase I transcription|ATP-dependent chromatin remodeling|nucleosome positioning|negative regulation of histone H3-K14 acetylation|termination of RNA polymerase II transcription|regulation of transcription by chromatin organization|regulation of transcriptional start site selection at RNA polymerase II promoter|nucleosome mobilization|Unknown|transcription elongation from RNA polymerase II promoter chromatin DNA binding|DNA-dependent ATPase activity|methylated histone residue binding|DNA binding|rDNA binding nuclear chromatin|SLIK (SAGA-like) complex|mitochondrion|SAGA complex|nucleolar chromatin
YOR035C YOR035C SHE4 hom Verified 4.20730094488397 1.29219437045188e-05 yes 14 0.00144582529854074 95 NA FF|FT CYTOSKELETON ORGANIZATION|RNA LOCALIZATION Protein containing a UCS (UNC-45/CRO1/SHE4) domain, binds to myosin motor domains to regulate myosin function; involved in endocytosis, polarization of the actin cytoskeleton, and asymmetric mRNA localization mating type switching|intracellular mRNA localization|actin cytoskeleton organization myosin binding cytoplasm
YEL041W YEL041W YEF1 hom Verified 4.13761523952952 1.75467102558769e-05 yes 15 7.86632232267861e-05 14 NA FT NUCLEOTIDE METABOLISM|COFACTOR METABOLISM ATP-NADH kinase; phosphorylates both NAD and NADH; homooctameric structure consisting of 60-kDa subunits; similar to Pos5p; overexpression complements certain pos5 phenotypes; YEF1 has a paralog, UTR1, that arose from the whole genome duplication NADP biosynthetic process NAD+ kinase activity|NADH kinase activity cellular_component
YNL175C YNL175C NOP13 hom Verified 4.11991218143143 1.89508415078489e-05 yes 16 4.6903913887275e-05 18 NA FT NUCLEUS Nucleolar protein found in preribosomal complexes; contains an RNA recognition motif (RRM); relative distribution to the nucleolus increases upon DNA replication stress biological_process RNA binding nucleolus|preribosome
YHR183W YHR183W GND1 hom Verified 4.07076499120431 2.34295019103751e-05 yes 17 3.67059831169783e-05 3 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS MITOCHONDRION 6-phosphogluconate dehydrogenase (decarboxylating); catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone and adaptation to oxidative stress; GND1 has a paralog, GND2, that arose from the whole genome duplication cellular response to oxidative stress|pentose-phosphate shunt, oxidative branch phosphogluconate dehydrogenase (decarboxylating) activity mitochondrion|cytoplasm
YHR095W_d YHR095W YHR095W hom Dubious 4.01054405849028 3.02894971876857e-05 yes 18 2.63660951864506e-05 12 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YLR320W YLR320W MMS22 hom Verified 3.99779494591353 3.19676497490217e-05 yes 19 3.06926288796487e-05 16 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION NUCLEUS UBIQUITIN LIGASE COMPLEX Subunit of an E3 ubiquitin ligase complex involved in replication repair; stabilizes protein components of the replication fork, such as the fork-pausing complex and leading strand polymerase, preventing fork collapse and promoting efficient recovery during replication stress; required for accurate meiotic chromosome segregation replication fork processing|double-strand break repair|recombinational repair|meiotic sister chromatid segregation|response to DNA damage stimulus molecular_function Cul8-RING ubiquitin ligase complex|nucleus
YPL072W YPL072W UBP16 hom Verified 3.95500574117158 3.8266406953072e-05 yes 20 1.6639048982335e-05 16 NA FT PROTEOLYSIS MITOCHONDRION Deubiquitinating enzyme anchored to the outer mitochondrial membrane, probably not important for general mitochondrial functioning, but may perform a more specialized function at mitochondria protein deubiquitination ubiquitin-specific protease activity mitochondrial outer membrane|cytoplasm
YJL073W YJL073W JEM1 hom Verified 3.86674605046268 5.51485884038972e-05 yes 21 8.35519973152952e-05 35 NA FT PROTEOLYSIS ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM DnaJ-like chaperone required for nuclear membrane fusion during mating, localizes to the ER membrane; exhibits genetic interactions with KAR2 karyogamy involved in conjugation with cellular fusion|ER-associated protein catabolic process|protein folding in endoplasmic reticulum unfolded protein binding|chaperone binding endoplasmic reticulum|nuclear outer membrane-endoplasmic reticulum membrane network
YER083C YER083C GET2 hom Verified 3.82135765539401 6.63595054224642e-05 yes 22 0.00255024794205699 92 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS Subunit of the GET complex; involved in insertion of proteins into the ER membrane; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for meiotic nuclear division retrograde vesicle-mediated transport, Golgi to ER|protein insertion into ER membrane protein anchor integral to membrane|endoplasmic reticulum|GET complex
YMR153W YMR153W NUP53 hom Verified 3.77781268417395 7.91059007624829e-05 yes 23 4.0392672357962e-05 15 NA FT PROTEIN LOCALIZATION|CELL CYCLE|CELL DIVISION|RNA LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS NUCLEAR PORE FG-nucleoporin component of central core of nuclear pore complex (NPC); also part of the NPC nuclear basket; contributes directly to nucleocytoplasmic transport; involved in regulation of transcription and mitosis; induces membrane tubulation, which may contribute to nuclear pore assembly; NUP53 has a paralog, ASM4, that arose from the whole genome duplication positive regulation of transcription, DNA-dependent|NLS-bearing substrate import into nucleus|regulation of protein desumoylation|nuclear pore organization|protein import into nucleus|regulation of mitosis|mitotic cell cycle spindle assembly checkpoint nucleocytoplasmic transporter activity|phospholipid binding|single-stranded DNA binding nuclear pore central transport channel|nuclear pore nuclear basket|integral to membrane|nuclear pore
YCR051W_p YCR051W YCR051W hom Uncharacterized 3.71372571409708 0.000102115071593595 yes 24 0.000145543348079513 28 NA FT NUCLEUS Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; contains ankyrin (Ank) repeats; YCR051W is not an essential gene biological_process molecular_function nucleus|cytoplasm
YDR035W YDR035W ARO3 hom Verified 3.71356692923531 0.000102179193270071 yes 25 0.00497855796109484 152 NA FF|FT KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS|MITOCHONDRION 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase, catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by phenylalanine or high concentration of tyrosine or tryptophan aromatic amino acid family biosynthetic process 3-deoxy-7-phosphoheptulonate synthase activity mitochondrion|nucleus|cytoplasm
YGR038W YGR038W ORM1 hom Verified 3.6928997672511 0.000110855712602253 yes 26 0.000700494082625926 34 NA FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Evolutionarily conserved protein, similar to Orm2p, required for resistance to agents that induce unfolded protein response; Orm1p and Orm2p together control membrane biogenesis by coordinating lipid homeostasis with protein quality control cellular sphingolipid homeostasis|negative regulation of sphingolipid biosynthetic process|response to unfolded protein molecular_function integral to membrane|endoplasmic reticulum|SPOTS complex
YOR205C YOR205C GEP3 hom Verified 3.67392366550164 0.000119427058304163 yes 27 0.00015470820511312 40 NA FT MITOCHONDRION Protein required for mitochondrial ribosome small subunit biogenesis; null mutant is defective in respiration and in maturation of 15S rRNA; protein is localized to the mitochondrial inner membrane; null mutant interacts synthetically with prohibitin (phb1) maturation of SSU-rRNA molecular_function mitochondrion|mitochondrial inner membrane
YIL005W YIL005W EPS1 hom Verified 3.64220384872127 0.000135156938862595 yes 28 0.000132757734984867 36 NA FT PROTEIN LOCALIZATION|PROTEOLYSIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM ER protein with chaperone and co-chaperone activity, involved in retention of resident ER proteins; has a role in recognizing proteins targeted for ER-associated degradation (ERAD), member of the protein disulfide isomerase family protein retention in ER lumen|ER-associated protein catabolic process unfolded protein binding|protein disulfide isomerase activity|chaperone binding endoplasmic reticulum membrane
YDR169C-A_p YDR169C-A YDR169C-A hom Uncharacterized 3.63727983650536 0.000137766266212335 yes 29 0.000217015716912402 19 NA Putative protein of unknown function; identified by fungal homology and RT-PCR biological_process molecular_function cellular_component
YGL133W YGL133W ITC1 hom Verified 3.62426171508774 0.000144894025337028 yes 30 0.000306516694177821 22 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS Subunit of the ATP-dependent Isw2p-Itc1p chromatin remodeling complex, required for repression of a-specific genes, repression of early meiotic genes during mitotic growth, and repression of INO1; similar to mammalian Acf1p, the regulatory subunit of the mammalian ATP-utilizing chromatin assembly and modifying factor (ACF) complex negative regulation of transcription from RNA polymerase II promoter by pheromones|chromatin remodeling|chromatin silencing at telomere molecular_function chromatin accessibility complex
YBL093C YBL093C ROX3 hom Verified 3.60782536780346 0.000154387098608134 yes 31 0.000455690034315684 37 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS RNA POL II, HOLOENZYME Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme negative regulation of transcription from RNA polymerase II promoter|transcriptional open complex formation at RNA polymerase II promoter|RNA polymerase II transcriptional preinitiation complex assembly|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II transcription factor recruiting transcription factor activity core mediator complex|nucleus
YPL105C YPL105C SYH1 hom Verified 3.60304974830618 0.000157252653064248 yes 32 0.000129100501092797 23 NA FT PROTEIN LOCALIZATION MITOCHONDRION Protein of unknown function that influences nuclear pore distribution; co-purifies with ribosomes; contains a GYF domain, which bind proline-rich sequences; deletion extends chronological lifespan; SYH1 has a paralog, SMY2, that arose from the whole genome duplication nuclear pore distribution molecular_function mitochondrion|ribosome|cytoplasmic mRNA processing body|extrinsic to membrane|cytoplasm
YNL335W_p YNL335W DDI3 hom Uncharacterized 3.5939842598243 0.000162829759479659 yes 33 0.000169456058481306 20 NA Protein of unknown function; expression is induced over 100-fold by DNA damage; induction decreased in rad6 and rad18 mutants biological_process molecular_function cellular_component
YCR092C YCR092C MSH3 hom Verified 3.54235129128798 0.000198288478437286 yes 34 0.000392486908092816 38 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME Mismatch repair protein, forms dimers with Msh2p that mediate repair of insertion or deletion mutations and removal of nonhomologous DNA ends, contains a PCNA (Pol30p) binding motif required for genome stability mismatch repair|mitotic recombination|meiotic mismatch repair|removal of nonhomologous ends|DNA recombination DNA insertion or deletion binding|mismatched DNA binding|double-strand/single-strand DNA junction binding|loop DNA binding|Y-form DNA binding MutSbeta complex|nucleus|cytoplasm
YLR370C YLR370C ARC18 hom Verified 3.51497103214221 0.000219900979455947 yes 35 0.00459068140428383 125 NA FF|FT PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION MITOCHONDRION|CYTOSKELETON Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches mitochondrion inheritance|actin filament organization|establishment of mitochondrion localization molecular_function mitochondrion|Arp2/3 protein complex
YLL042C YLL042C ATG10 hom Verified 3.3683277824139 0.000378128135710422 yes 36 9.01050973780076e-05 15 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS Conserved E2-like conjugating enzyme that mediates formation of the Atg12p-Atg5p conjugate, which is a critical step in autophagy piecemeal microautophagy of nucleus|cellular protein modification process|mitochondrion degradation|macroautophagy|CVT pathway Atg12 ligase activity cellular_component
YMR145C YMR145C NDE1 hom Verified 3.35074825500609 0.000402967666206093 yes 37 0.000302201137375505 19 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION Mitochondrial external NADH dehydrogenase, a type II NAD(P)H:quinone oxidoreductase that catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p provide cytosolic NADH to the mitochondrial respiratory chain glucose catabolic process to ethanol|NADH oxidation|chronological cell aging NADH dehydrogenase activity mitochondrion
YKL038W YKL038W RGT1 hom Verified 3.26493100450321 0.00054745371682275 yes 38 0.00226157537173343 47 NA FT TRANSCRIPTION FROM RNA POL II|CARBOHYDRATE METABOLISM NUCLEUS Glucose-responsive transcription factor; regulates expression of several glucose transporter (HXT) genes in response to glucose; binds to promoters and acts both as a transcriptional activator and repressor; RGT1 has a paralog, EDS1, that arose from the whole genome duplication glucose transport|regulation of glucose import|negative regulation of transcription from RNA polymerase II promoter|glucose metabolic process|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription nucleus
YOL076W YOL076W MDM20 hom Verified 3.26106228734014 0.000554978275609975 yes 39 0.00167719451247859 79 NA FF|FT MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION Non-catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes N-acetylation of proteins with specific N-terminal sequences; involved in mitochondrial inheritance and actin assembly mitochondrion inheritance|N-terminal peptidyl-methionine acetylation|cytoskeleton organization peptide alpha-N-acetyltransferase activity NatB complex
YGR241C YGR241C YAP1802 hom Verified 3.25009521405305 0.000576831878390121 yes 40 0.000986313570636588 42 NA FT VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON Protein of the AP180 family, involved in clathrin cage assembly; binds Pan1p and clathrin; YAP1802 has a paralog, YAP1801, that arose from the whole genome duplication endocytosis clathrin binding actin cortical patch
YBL057C YBL057C PTH2 hom Verified 3.24957857246654 0.000577880724938035 yes 41 0.000946559126560694 32 NA FT PROTEOLYSIS MITOCHONDRION One of two (see also PTH1) mitochondrially-localized peptidyl-tRNA hydrolases; negatively regulates the ubiquitin-proteasome pathway via interactions with ubiquitin-like ubiquitin-associated proteins; dispensable for cell growth negative regulation of proteasomal ubiquitin-dependent protein catabolic process aminoacyl-tRNA hydrolase activity mitochondrial outer membrane|mitochondrion|cytoplasm
YML018C YML018C YML018C hom Verified 3.1980664361283 0.000691762012610008 yes 42 0.000820843873728268 45 NA Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the membrane of the vacuole; physical interaction with Atg27p suggests a possible role in autophagy; YML018C is not an essential gene; relative distribution to the vacuolar membrane decreases upon DNA replication stress; YML018C has a paralog, THI74, that arose from the whole genome duplication biological_process molecular_function fungal-type vacuole membrane|integral to membrane
YOR367W YOR367W SCP1 hom Verified 3.17651195187282 0.000745288237078899 yes 43 0.00160178262329582 42 NA FT CYTOSKELETON ORGANIZATION CYTOSKELETON Component of yeast cortical actin cytoskeleton, binds and cross links actin filaments; originally identified by its homology to calponin (contains a calponin-like repeat) but the Scp1p domain structure is more similar to transgelin actin filament organization|chronological cell aging actin filament binding|protein binding, bridging actin cortical patch
YDR007W YDR007W TRP1 hom Verified 3.16053953457269 0.000787386162223961 yes 44 0.0485123404782673 454 NA FF|FT KETONE METABOLISM|AMINO ACID METABOLISM Phosphoribosylanthranilate isomerase that catalyzes the third step in tryptophan biosynthesis; in 2004, the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA) tryptophan biosynthetic process phosphoribosylanthranilate isomerase activity cytoplasm
YDL085C-A_p YDL085C-A YDL085C-A hom Uncharacterized 3.04732360977571 0.0011544449588792 no 45 0.00121648363195721 32 NA FT NUCLEUS Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus biological_process molecular_function nucleus|cytoplasm
YER121W_p YER121W YER121W hom Uncharacterized 3.04053103077164 0.00118080677393143 no 46 0.00208128543660452 34 NA Putative protein of unknown function; may be involved in phosphatase regulation and/or generation of precursor metabolites and energy biological_process molecular_function cellular_component
YER111C YER111C SWI4 hom Verified 3.03352931220409 0.00120855614126059 no 47 0.00166239445547203 71 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE NUCLEUS|CHROMOSOME DNA binding component of the SBF complex (Swi4p-Swi6p); a transcriptional activator that in concert with MBF (Mbp1-Swi6p) regulates late G1-specific transcription of targets including cyclins and genes required for DNA synthesis and repair; acetylation at two sites, K1016 and K1066, regulates interaction with Swi6p positive regulation of transcription from RNA polymerase II promoter in response to heat stress|positive regulation of transcription involved in G1/S phase of mitotic cell cycle sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription SBF transcription complex|nuclear chromatin
YDL204W YDL204W RTN2 hom Verified 3.02594226635121 0.00123929812248246 no 48 0.00354380198241278 61 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Reticulon protein; stabilizes membrane curvature; involved in nuclear pore assembly and maintenance of tubular ER morphology; interacts with exocyst subunit Sec6p, Yip3p, and Sbh1p; much less abundant than Rtn1p; rtn1 rtn2 yop1 triple mutant lacks tubular ER; member of RTNLA (reticulon-like A) subfamily; protein increases in abundance and relocalizes to plasma membrane upon DNA replication stress; RTN2 has a paralog, RTN1, that arose from the whole genome duplication endoplasmic reticulum tubular network organization|endoplasmic reticulum tubular network maintenance molecular_function endoplasmic reticulum|cortical endoplasmic reticulum|endoplasmic reticulum tubular network
YDR515W YDR515W SLF1 hom Verified 3.00902247513055 0.00131044863371382 no 49 0.00142412841952228 34 NA FT TRANSLATION|ION HOMEOSTASIS|ION HOMEOSTASIS RNA binding protein that associates with polysomes; may be involved in regulating mRNA translation; involved in the copper-dependent mineralization of copper sulfide complexes on cell surface in cells cultured in copper salts; SLF1 has a paralog, SRO9, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress cellular copper ion homeostasis|regulation of translation RNA binding polysome|cytoplasm
YJR110W YJR110W YMR1 hom Verified 3.00776887591393 0.00131586602176446 no 50 0.00132674761684402 22 NA FT LIPID METABOLISM Phosphatidylinositol 3-phosphate (PI3P) phosphatase; involved in various protein sorting pathways, including CVT targeting and endosome to vacuole transport; has similarity to the conserved myotubularin dual specificity phosphatase family phosphatidylinositol dephosphorylation mRNA binding|phosphatidylinositol-3-phosphatase activity cytoplasm
YDR234W YDR234W LYS4 hom Verified 2.99855445539227 0.00135631837524839 no 51 0.00160014769354063 33 NA FT KETONE METABOLISM|AMINO ACID METABOLISM MITOCHONDRION Homoaconitase, catalyzes the conversion of homocitrate to homoisocitrate, which is a step in the lysine biosynthesis pathway lysine biosynthetic process via aminoadipic acid homoaconitate hydratase activity mitochondrion
YGR106C YGR106C VOA1 hom Verified 2.97498775869521 0.00146500119897037 no 52 0.00915643952962164 106 NA FF|FT PROTEIN COMPLEX ORG/BIOGENESIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Endoplasmic reticulum protein that functions, together with other assembly factors, in assembly of the V0 sector of the vacuolar ATPase (V-ATPase); null mutation enhances the V-ATPase deficiency of a vma21 mutant impaired in ER retrieval protein complex assembly molecular_function fungal-type vacuole membrane|endoplasmic reticulum membrane
YLR403W YLR403W SFP1 hom Verified 2.95930916318982 0.00154164801910979 no 53 0.00139887211293588 75 NA FT TRANSCRIPTION FROM RNA POL II|RIBOSOME BIOGENESIS NUCLEUS Regulates transcription of ribosomal protein and biogenesis genes; regulates response to nutrients and stress, G2/M transitions during mitotic cell cycle and DNA-damage response, and modulates cell size; regulated by TORC1 and Mrs6p; sequence of zinc finger, ChIP localization data, and protein-binding microarray (PBM) data, and computational analyses suggest it binds DNA directly at highly active RP genes and indirectly through Rap1p at others; can form the [ISP+] prion positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter|regulation of cell size|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II transcription factor binding transcription factor activity nucleus|cytoplasm
YCR079W YCR079W PTC6 hom Verified 2.95162768285009 0.00158051912686455 no 54 0.00271133940296412 73 NA FT RESPONSE TO NUTRIENT LEVELS MITOCHONDRION Mitochondrial type 2C protein phosphatase (PP2C) with similarity to mammalian PP1Ks; involved in mitophagy; null mutant is sensitive to rapamycin and has decreased phosphorylation of the Pda1 subunit of pyruvate dehydrogenase mitochondrion degradation|positive regulation of catalytic activity|macroautophagy|protein dephosphorylation protein serine/threonine phosphatase activity mitochondrion|mitochondrial matrix|mitochondrial intermembrane space
YNR062C_p YNR062C YNR062C hom Uncharacterized 2.95090179857717 0.00158423818501032 no 55 0.00173057268483574 53 NA Putative membrane protein of unknown function biological_process molecular_function integral to membrane
YDR129C YDR129C SAC6 hom Verified 2.89725092000563 0.00188224267070145 no 56 0.0417420722431814 303 NA FF|FT VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CELL DIVISION|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH|CYTOSKELETON Fimbrin, actin-bundling protein; cooperates with Scp1p (calponin/transgelin) in the organization and maintenance of the actin cytoskeleton; relocalizes from plasma membrane to cytoplasm upon DNA replication stress bipolar cellular bud site selection|actin filament organization|endocytosis|response to osmotic stress actin filament binding|protein binding, bridging actin filament bundle|mating projection tip|actin cortical patch
YGR212W YGR212W SLI1 hom Verified 2.89479146398484 0.00189705247525188 no 57 0.00222223639869227 33 NA FT ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|PLASMA MEMBRANE N-acetyltransferase, confers resistance to the sphingolipid biosynthesis inhibitor myriocin (ISP-1) by converting it into N-acetyl-myriocin, co-operates with Ypk1p in mediating resistance to myriocin response to drug N-acetyltransferase activity nuclear envelope|plasma membrane
YLR363C YLR363C NMD4 hom Verified 2.89276123158756 0.00190935737460692 no 58 0.00178982295087928 34 NA Protein that may be involved in nonsense-mediated mRNA decay; interacts with Nam7p, relocalizes from nucleus to cytoplasmic foci upon DNA replication stress nuclear-transcribed mRNA catabolic process, nonsense-mediated decay molecular_function cytoplasm
YMR090W_p YMR090W YMR090W hom Uncharacterized 2.8764995505792 0.00201056384034544 no 59 0.0030059822550876 55 NA Putative protein of unknown function with similarity to DTDP-glucose 4,6-dehydratases; GFP-fusion protein localizes to the cytoplasm; up-regulated in response to the fungicide mancozeb; not essential for viability biological_process molecular_function cytoplasm
YLR285C-A_p YLR285C-A YLR285C-A hom Uncharacterized 2.86642432544239 0.00207568698515067 no 60 0.00127443028155983 40 NA Putative protein of unknown function; identified by fungal homology and RT-PCR biological_process molecular_function cellular_component
YAR023C_p YAR023C YAR023C hom Uncharacterized 2.85696471404763 0.00213856691875066 no 61 0.00192728445661975 49 NA Putative integral membrane protein, member of DUP240 gene family biological_process molecular_function cellular_component
YMR294W-A_d YMR294W-A YMR294W-A hom Dubious 2.84673355280059 0.00220851576477851 no 62 0.00278315864845964 39 NA Dubious open reading frame unlikely to encode a functional protein, substantially overlaps YMR295C; deletion causes sensitivity to unfolded protein response-inducing agents Unknown Unknown Unknown
YLL040C YLL040C VPS13 hom Verified 2.83100804084698 0.00232007772555225 no 63 0.0027541981699119 76 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT MITOCHONDRION|GOLGI APPARATUS Protein of unknown function; heterooligomeric or homooligomeric complex; peripherally associated with membranes; involved in sporulation, vacuolar protein sorting, prospore membrane formation and protein-Golgi retention; homologous to human CHAC and COH1 which are involved in chorea acanthocytosis and Cohen syndrome, respectively protein retention in Golgi apparatus|late endosome to vacuole transport|protein targeting to vacuole|ascospore-type prospore membrane assembly molecular_function endosome|mitochondrion|prospore membrane|extrinsic to membrane
YMR293C YMR293C HER2 hom Verified 2.79376267521332 0.0026049348914778 no 64 0.0058295730059341 85 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION MITOCHONDRION Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; required for remodeling of ER caused by Hmg2p overexpression; similar to bacterial GatA glutamyl-tRNA amidotransferase endoplasmic reticulum organization|glutaminyl-tRNAGln biosynthesis via transamidation glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity mitochondrion|glutamyl-tRNA(Gln) amidotransferase complex
YCR036W YCR036W RBK1 hom Verified 2.79251794172305 0.00261497835710244 no 65 0.0113563617934209 110 NA FT CARBOHYDRATE METABOLISM NUCLEUS Putative ribokinase D-ribose metabolic process ribokinase activity|ATP binding nucleus|cytoplasm
YMR071C YMR071C TVP18 hom Verified 2.79223266978004 0.00261728507220063 no 66 0.00817329318066729 144 NA FF|FT VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; may interact with ribosomes, based on co-purification experiments vesicle-mediated transport molecular_function integral to membrane|integral to Golgi membrane|clathrin-coated vesicle
YLR330W YLR330W CHS5 hom Verified 2.78762370522491 0.00265480890707417 no 67 0.0110477911675564 158 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL CYCLE|CELL WALL ORG/BIOGENESIS|CELL DIVISION|CARBOHYDRATE METABOLISM GOLGI APPARATUS|SITE OF POLARIZED GROWTH Component of the exomer complex, which also contains Csh6p, Bch1p, Bch2p, and Bud7p and is involved in export of selected proteins, such as chitin synthase Chs3p, from the Golgi to the plasma membrane ascospore wall assembly|conjugation with cellular fusion|cell wall chitin catabolic process|Golgi to plasma membrane transport|cellular bud site selection|regulation of transcription, DNA-dependent molecular_function mating projection tip|cytoplasm|exomer complex
YGR022C_d YGR022C YGR022C hom Dubious 2.78639634858415 0.00266488300441416 no 68 0.000755923991413729 15 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W Unknown Unknown Unknown
YNL294C YNL294C RIM21 hom Verified 2.75627685900909 0.0029231744037592 no 69 0.00709876619379388 150 NA FF|FT ION HOMEOSTASIS|CELL WALL ORG/BIOGENESIS|ION HOMEOSTASIS PLASMA MEMBRANE pH sensor molecule, component of the RIM101 pathway; has a role in cell wall construction and alkaline pH response; is glycosylated and phosphorylated; interacts with Dfg16p and Rim9p to form a pH-sensing complex; localization to the plasma membrane is dependent on Dfg16p and Rim9p; has similarity to A. nidulans PalH fungal-type cell wall biogenesis|ascospore formation|invasive growth in response to glucose limitation molecular_function integral to membrane
YPL134C YPL134C ODC1 hom Verified 2.7453958893331 0.00302189702629348 no 70 0.00210427155540947 73 NA FT MITOCHONDRION Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for lysine and glutamate biosynthesis and lysine catabolism; suppresses, in multicopy, an fmc1 null mutation mitochondrial transport dicarboxylic acid transmembrane transporter activity mitochondrion|integral to membrane|mitochondrial inner membrane
YCL045C YCL045C EMC1 hom Verified 2.73588099947142 0.00311067598680744 no 71 0.00279068867301596 79 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Member of conserved endoplasmic reticulum membrane complex; involved in efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; interacts with Gal80p; homologous to worm H17B01.4/EMC-1, fly CG2943, and human KIAA0090 protein folding in endoplasmic reticulum molecular_function ER membrane protein complex|endoplasmic reticulum
YBL012C_d YBL012C YBL012C hom Dubious 2.71489286779801 0.00331486066444903 no 72 0.00331366307772203 87 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YFR010W YFR010W UBP6 hom Verified 2.71287885611738 0.00333507431568037 no 73 0.0129872780153303 97 NA FT PROTEOLYSIS Ubiquitin-specific protease situated in the base subcomplex of the 26S proteasome, releases free ubiquitin from branched polyubiquitin chains; works in opposition to Hul5p polyubiquitin elongation activity; mutant has aneuploidy tolerance protein deubiquitination ubiquitin-specific protease activity proteasome complex|proteasome regulatory particle
YGL186C YGL186C TPN1 hom Verified 2.70483962428346 0.0034168686645844 no 74 0.04925489665742 304 NA FF|FT PLASMA MEMBRANE Plasma membrane pyridoxine (vitamin B6) transporter; member of the purine-cytosine permease subfamily within the major facilitator superfamily; proton symporter with similarity to Fcy21p, Fcy2p, and Fcy22p vitamin transport vitamin transporter activity integral to membrane|plasma membrane
YLL047W_d YLL047W YLL047W hom Dubious 2.69149866811883 0.0035565891174483 no 75 0.00492406658273061 49 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene RNP1 Unknown Unknown Unknown
YMR201C YMR201C RAD14 hom Verified 2.66559199767472 0.00384264504331839 no 76 0.00485719508990938 65 NA FT RESPONSE TO DNA DAMAGE NUCLEUS Protein that recognizes and binds damaged DNA during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); contains zinc finger motif; homolog of human XPA protein nucleotide-excision repair, DNA damage recognition damaged DNA binding|zinc ion binding nucleotide-excision repair factor 1 complex|nucleus
YNL264C YNL264C PDR17 hom Verified 2.65916415981599 0.0039167392193533 no 77 0.00423237168860788 63 NA FT LIPID METABOLISM Phosphatidylinositol transfer protein (PITP), downregulates Plb1p-mediated turnover of phosphatidylcholine, found in the cytosol and microsomes, homologous to Pdr16p, deletion affects phospholipid composition Golgi to plasma membrane protein transport|phosphatidylserine metabolic process|response to drug|sterol biosynthetic process|Unknown|phospholipid transport|phospholipid biosynthetic process phosphatidylinositol transporter activity|phosphatidylcholine transporter activity endosome|cell periphery|cytosol|cytoplasm
YDR532C YDR532C KRE28 hom Verified 2.65189258763865 0.00400210003229621 no 78 0.00866220997301595 37 NA FT ENDOMEMBRANE SYSTEM|NUCLEUS|CHROMOSOME|CYTOSKELETON KINETOCHORE Subunit of a kinetochore-microtubule binding complex with Spc105p that bridges centromeric heterochromatin and kinetochore MAPs and motors, and is also required for sister chromatid bi-orientation and kinetochore binding of SAC components biological_process molecular_function chromosome, centromeric region|condensed nuclear chromosome kinetochore|spindle pole body
YJL063C YJL063C MRPL8 hom Verified 2.63911790623956 0.00415610328519871 no 79 0.00809419286302857 102 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit mitochondrial genome maintenance|mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YPR197C_d YPR197C YPR197C hom Dubious 2.63702633895844 0.00418181686502462 no 80 0.0222363848185293 211 NA FF Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YIR007W_p YIR007W YIR007W hom Uncharacterized 2.61748866533814 0.0044289715046646 no 81 0.00322628641198696 38 NA FT CARBOHYDRATE METABOLISM Putative glycosidase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YIR007W is a non-essential gene biological_process molecular_function cytoplasm
YGR045C_d YGR045C YGR045C hom Dubious 2.59503943994754 0.00472900326305092 no 82 0.00250650082851604 50 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YBR058C-A YBR058C-A TSC3 hom Verified 2.59160299548604 0.00477649707576322 no 83 0.081737290175142 571 NA FF|FT KETONE METABOLISM|LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Protein that stimulates the activity of serine palmitoyltransferase (Lcb1p, Lcb2p) several-fold; involved in sphingolipid biosynthesis 3-keto-sphinganine metabolic process|sphingolipid biosynthetic process enzyme activator activity SPOTS complex
YHL030W YHL030W ECM29 hom Verified 2.58524542369668 0.00486548519872931 no 84 0.00354013344267087 62 NA FT PROTEIN COMPLEX ORG/BIOGENESIS NUCLEUS Scaffold protein; assists in association of the proteasome core particle with the regulatory particle; degraded by the mature proteasome after assembly; contains HEAT-like repeats; protein increases in abundance and relocalizes from nucleus to cytoplasm upon DNA replication stress proteasome assembly protein complex scaffold proteasome complex|nucleus|cytoplasm
YPL090C YPL090C RPS6A hom Verified 2.5705429364997 0.00507696194961092 no 85 0.00561182036841587 93 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S6, no bacterial homolog; RPS6A has a paralog, RPS6B, that arose from the whole genome duplication cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) structural constituent of ribosome small-subunit processome|cytosolic small ribosomal subunit|90S preribosome
YGL089C YGL089C MF(ALPHA)2 hom Verified 2.55209971256346 0.00535379347878224 no 86 0.00389567065174125 70 NA FT SIGNALING Mating pheromone alpha-factor, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)1, which is more highly expressed than MF(ALPHA)2 pheromone-dependent signal transduction involved in conjugation with cellular fusion mating pheromone activity extracellular region
YPL039W_p YPL039W YPL039W hom Uncharacterized 2.55020711576689 0.0053829469955415 no 87 0.00850274089234161 100 NA Putative protein of unknown function; YPL039W is not an essential gene biological_process molecular_function cellular_component
YBR139W YBR139W YBR139W hom Verified 2.54883011486769 0.00540424689746438 no 88 0.00621230979311465 78 NA FT PROTEOLYSIS Putative serine type carboxypeptidase with a role in phytochelatin synthesis; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner phytochelatin biosynthetic process serine hydrolase activity|serine-type carboxypeptidase activity fungal-type vacuole
YCL040W YCL040W GLK1 hom Verified 2.54767184476129 0.00542222138025301 no 89 0.00569831718396012 80 NA FT CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY Glucokinase; catalyzes the phosphorylation of glucose at C6 in the first irreversible step of glucose metabolism; one of three glucose phosphorylating enzymes; expression regulated by non-fermentable carbon sources; GLK1 has a paralog, EMI2, that arose from the whole genome duplication glucose import|mannose metabolic process|glycolysis|glucose metabolic process glucokinase activity cytosol|plasma membrane
YOR187W YOR187W TUF1 hom Verified 2.54433048873107 0.0054743719469027 no 90 0.0255627398698777 117 NA FT TRANSLATION|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial translation elongation factor Tu; comprises both GTPase and guanine nucleotide exchange factor activities, while these activities are found in separate proteins in S. pombe and humans mitochondrial translational elongation|mitochondrial translation GTPase activity|translation elongation factor activity mitochondrion|mitochondrial matrix
YGR232W YGR232W NAS6 hom Verified 2.52546152007463 0.00577732172981381 no 91 0.00665085592809006 70 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS NUCLEUS Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); ortholog of human oncoprotein gankyrin, which interacts with the Rb tumor suppressor and CDK4/6 proteolysis|proteasome regulatory particle assembly molecular_function cytosol|nucleus|proteasome regulatory particle
YCR095W-A_p YCR095W-A YCR095W-A hom Uncharacterized 2.51843282928316 0.00589391825359627 no 92 0.00432143386191172 59 NA Putative protein of unknown function biological_process molecular_function cellular_component
YHR146W YHR146W CRP1 hom Verified 2.51617808957783 0.00593176098878244 no 93 0.0088138889641875 97 NA FT NUCLEUS Protein that binds to cruciform DNA structures biological_process DNA binding nucleus
YLR114C YLR114C AVL9 hom Verified 2.50938456238528 0.00604708691306414 no 94 0.00770479805102548 41 NA FT VESICLE-MEDIATED TRANSPORT Conserved protein involved in exocytic transport from the Golgi; mutation is synthetically lethal with apl2 vps1 double mutation; member of a protein superfamily with orthologs in diverse organisms; relocalizes from bud neck to cytoplasm upon DNA replication stress post-Golgi vesicle-mediated transport molecular_function cytoplasm
YBR183W YBR183W YPC1 hom Verified 2.49627655712996 0.00627523551018764 no 95 0.00794226680619043 60 NA FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS Alkaline ceramidase; also has reverse (CoA-independent) ceramide synthase activity; catalyzes both breakdown and synthesis of phytoceramide; overexpression confers fumonisin B1 resistance; YPC1 has a paralog, YDC1, that arose from the whole genome duplication ceramide catabolic process|ceramide biosynthetic process phytoceramidase activity|sphingosine N-acyltransferase activity integral to membrane|endoplasmic reticulum
YCR017C YCR017C CWH43 hom Verified 2.47605914334128 0.00664207852073062 no 96 0.0127984710635348 117 NA FT LIPID METABOLISM|CELL WALL ORG/BIOGENESIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE Putative sensor/transporter protein involved in cell wall biogenesis; contains 14-16 transmembrane segments and several putative glycosylation and phosphorylation sites; null mutation is synthetically lethal with pkc1 deletion fungal-type cell wall organization|GPI anchor biosynthetic process molecular_function integral to membrane|integral to plasma membrane|cellular bud neck|cellular bud tip
YPR172W_p YPR172W YPR172W hom Uncharacterized 2.47031470587248 0.00674971170333175 no 97 0.00523756512841925 71 NA FT OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM NUCLEUS Putative pyridoxal 5'-phosphate synthase; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance; YPR172W has a paralog, YLR456W, that arose from the whole genome duplication biological_process molecular_function nucleus|cytoplasm
YEL061C YEL061C CIN8 hom Verified 2.46223101662999 0.00690378493639477 no 98 0.00970279167971641 149 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION NUCLEUS|MITOCHONDRION|CHROMOSOME|CYTOSKELETON KINETOCHORE Kinesin motor protein involved in mitotic spindle assembly and chromosome segregation mitotic anaphase B|microtubule depolymerization|spindle pole body separation|mitotic spindle organization in nucleus|mitotic sister chromatid segregation plus-end-directed microtubule motor activity|minus-end-directed microtubule motor activity spindle microtubule|kinesin complex|mitochondrion|condensed nuclear chromosome kinetochore|kinetochore microtubule|astral microtubule
YGR260W YGR260W TNA1 hom Verified 2.46131247001803 0.0069214872304329 no 99 0.0107072038426626 83 NA FT MITOCHONDRION|PLASMA MEMBRANE High affinity nicotinic acid plasma membrane permease, responsible for uptake of low levels of nicotinic acid; expression of the gene increases in the absence of extracellular nicotinic acid or para-aminobenzoate (PABA) nicotinamide mononucleotide transport nicotinamide mononucleotide transmembrane transporter activity mitochondrion|integral to membrane|integral to plasma membrane
YLR192C YLR192C HCR1 hom Verified 2.44680567286619 0.0072064262326709 no 100 0.0178715360157601 161 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION Dual function protein involved in translation initiation as a substoichiometric component (eIF3j) of translation initiation factor 3 (eIF3) and required for processing of 20S pre-rRNA; binds to eIF3 subunits Rpg1p and Prt1p and 18S rRNA cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) translation initiation factor activity eukaryotic translation initiation factor 3 complex
YHR049C-A_d YHR049C-A YHR049C-A hom Dubious 2.41509807879744 0.00786548657036708 no 101 0.00556611791419092 59 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YOL020W YOL020W TAT2 hom Verified 2.39913529604757 0.00821692066856098 no 102 0.0117465132481735 131 NA FT PLASMA MEMBRANE High affinity tryptophan and tyrosine permease, overexpression confers FK506 and FTY720 resistance aromatic amino acid transport|tryptophan transport high-affinity tryptophan transmembrane transporter activity|aromatic amino acid transmembrane transporter activity integral to membrane|plasma membrane
YJL116C YJL116C NCA3 hom Verified 2.39721772655359 0.00826005204309114 no 103 0.00507330613928858 45 NA FT MITOCHONDRION ORGANIZATION MITOCHONDRION Protein involved in mitochondrion organization; functions with Nca2p to regulate mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p) of the Fo-F1 ATP synthase; member of the SUN family; expression induced in cells treated with the mycotoxin patulin; NCA3 has a paralog, UTH1, that arose from the whole genome duplication mitochondrion organization molecular_function cellular_component
YER106W YER106W MAM1 hom Verified 2.37625557833208 0.00874467207834239 no 104 0.0064939548226001 113 NA FT CELL CYCLE|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME KINETOCHORE Monopolin, kinetochore associated protein involved in chromosome attachment to meiotic spindle meiotic chromosome segregation|meiotic sister chromatid cohesion involved in meiosis I molecular_function condensed nuclear chromosome kinetochore|monopolin complex
YLL015W YLL015W BPT1 hom Verified 2.37478876524976 0.00877949780703353 no 105 0.00640631639961912 53 NA FT ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS ABC type transmembrane transporter of MRP/CFTR family, found in vacuolar membrane, involved in the transport of unconjugated bilirubin and in heavy metal detoxification via glutathione conjugates, along with Ycf1p cadmium ion transport|bilirubin transport bilirubin transmembrane transporter activity|cadmium ion transmembrane transporter activity fungal-type vacuole membrane|integral to membrane
YDR484W YDR484W VPS52 hom Verified 2.3617006132005 0.00909566323479591 no 106 0.0365098240269957 166 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT GOLGI APPARATUS|CYTOSKELETON Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; involved in localization of actin and chitin actin filament-based process|Golgi to vacuole transport|retrograde transport, endosome to Golgi protein binding Golgi apparatus|GARP complex
YCR100C_p YCR100C YCR100C hom Uncharacterized 2.35384465428286 0.00929018711148193 no 107 0.0145950860020165 102 NA Putative protein of unknown function biological_process molecular_function integral to membrane
YDR169C YDR169C STB3 hom Verified 2.35312634907183 0.00930815361529128 no 108 0.00484072476130204 32 NA FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS NUCLEUS Ribosomal RNA processing element (RRPE)-binding protein; involved in the glucose-induced transition from quiescence to growth; restricted to nucleus in quiescent cells, released into cytoplasm after glucose repletion; binds Sin3p; relative distribution to the nucleus increases upon DNA replication stress positive regulation of transcription from RNA polymerase II promoter by glucose sequence-specific DNA binding nucleus|cytoplasm
YER001W YER001W MNN1 hom Verified 2.34004579663059 0.00964068769653729 no 109 0.0048177296825501 48 NA FT CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Alpha-1,3-mannosyltransferase, integral membrane glycoprotein of the Golgi complex, required for addition of alpha1,3-mannose linkages to N-linked and O-linked oligosaccharides, one of five S. cerevisiae proteins of the MNN1 family N-glycan processing|protein O-linked glycosylation alpha-1,3-mannosyltransferase activity Golgi apparatus
YBR069C YBR069C TAT1 hom Verified 2.33991967897114 0.00964394375414106 no 110 0.116342544815031 459 NA FF|FT PLASMA MEMBRANE Amino acid transporter for valine, leucine, isoleucine, and tyrosine; low-affinity tryptophan and histidine transporter; overexpression confers FK506 and FTY720 resistance; protein abundance increases in response to DNA replication stress amino acid transport|tyrosine transport|tryptophan transport|transmembrane transport amino acid transmembrane transporter activity|low-affinity tryptophan transmembrane transporter activity integral to membrane|plasma membrane
YBL090W YBL090W MRP21 hom Verified 2.33922335051805 0.00966193860377036 no 111 0.0179924344524347 138 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the small subunit; MRP21 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequences mitochondrial translational initiation|mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial small ribosomal subunit
YLR110C YLR110C CCW12 hom Verified 2.32959319646482 0.00991383104308983 no 112 0.0363235109188277 292 NA FF|FT CELL WALL ORG/BIOGENESIS SITE OF POLARIZED GROWTH Cell wall mannoprotein; plays a role in maintenance of newly synthesized areas of cell wall; localizes to periphery of small buds, septum region of larger buds, and shmoo tip; CCW12 has a paralog, YDR134C, that arose from the whole genome duplication conjugation with cellular fusion|agglutination involved in conjugation with cellular fusion|fungal-type cell wall organization molecular_function fungal-type cell wall|mating projection tip|cellular bud tip
YOR291W YOR291W YPK9 hom Verified 2.3098444780005 0.0104483829280134 no 113 0.00623216863491049 43 NA FT ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome biological_process molecular_function fungal-type vacuole membrane|integral to membrane
YLR268W YLR268W SEC22 hom Verified 2.30010955286286 0.010721007104541 no 114 0.039781171536198 274 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS R-SNARE protein; assembles into SNARE complex with Bet1p, Bos1p and Sed5p; cycles between the ER and Golgi complex; involved in anterograde and retrograde transport between the ER and Golgi; synaptobrevin homolog retrograde vesicle-mediated transport, Golgi to ER|ER to Golgi vesicle-mediated transport|vesicle fusion with Golgi apparatus|vesicle fusion with endoplasmic reticulum|vesicle fusion SNAP receptor activity SNARE complex|integral to membrane|Golgi apparatus|endoplasmic reticulum|ER to Golgi transport vesicle membrane
YLR415C_p YLR415C YLR415C hom Uncharacterized 2.29919122604959 0.0107470415111322 no 115 0.0113476938647717 83 NA FT MITOCHONDRION Putative protein of unknown function; YLR415C is not an essential gene biological_process molecular_function cellular_component
YDR249C_p YDR249C YDR249C hom Uncharacterized 2.29548948333574 0.0108525442114528 no 116 0.00635647280181343 66 NA Putative protein of unknown function biological_process molecular_function cellular_component
YAL008W YAL008W FUN14 hom Verified 2.29478579605586 0.0108727015257515 no 117 0.0170750512473835 98 NA FT MITOCHONDRION Mitochondrial protein of unknown function biological_process molecular_function mitochondrial outer membrane|mitochondrion
YMR276W YMR276W DSK2 hom Verified 2.29324269231437 0.0109170182574819 no 118 0.0112311167195253 103 NA FT CELL CYCLE|PROTEOLYSIS|CYTOSKELETON ORGANIZATION NUCLEUS Nuclear-enriched ubiquitin-like polyubiquitin-binding protein; required for spindle pole body (SPB) duplication and for transit through the G2/M phase of the cell cycle; involved in proteolysis; interacts with the proteasome; protein abundance increases in response to DNA replication stress ER-associated protein catabolic process|spindle pole body duplication associated with nuclear envelope protein binding, bridging nucleus
YMR009W YMR009W ADI1 hom Verified 2.29170055150942 0.0109614642892087 no 119 0.00798878368737274 106 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS NUCLEUS Acireductone dioxygenease involved in the methionine salvage pathway; ortholog of human MTCBP-1; transcribed as polycistronic mRNA with YMR010W and regulated post-transcriptionally by RNase III (Rnt1p) cleavage; ADI1 mRNA is induced in heat shock conditions L-methionine salvage from methylthioadenosine oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen nucleus|cytoplasm
YPL206C YPL206C PGC1 hom Verified 2.28151442510564 0.0112590120527427 no 120 0.0108064925548647 109 NA FT LIPID METABOLISM|CARBOHYDRATE METABOLISM MITOCHONDRION Phosphatidyl Glycerol phospholipase C; regulates the phosphatidylglycerol (PG) content via a phospholipase C-type degradation mechanism; contains glycerophosphodiester phosphodiesterase motifs glycerophospholipid catabolic process|phosphatidylglycerol catabolic process phosphatidylglycerol phospholipase C activity mitochondrion|lipid particle
YJL181W_p YJL181W YJL181W hom Uncharacterized 2.28089863098092 0.0112772229946292 no 121 0.00419357792199161 62 NA Putative protein of unknown function; expression is cell-cycle regulated as shown by microarray analysis; potential regulatory target of Mbp1p, which binds to the YJL181W promoter region; YJL181W has a paralog, YJR030C, that arose from the whole genome duplication biological_process molecular_function cellular_component
YLR332W YLR332W MID2 hom Verified 2.27582422545439 0.0114282660942223 no 122 0.0130703412650873 158 NA FT RNA PROCESSING|SIGNALING|CELL WALL ORG/BIOGENESIS|PEROXISOME ORGANIZATION SITE OF POLARIZED GROWTH|PLASMA MEMBRANE O-glycosylated plasma membrane protein that acts as a sensor for cell wall integrity signaling and activates the pathway; interacts with Rom2p, a guanine nucleotide exchange factor for Rho1p, and with cell integrity pathway protein Zeo1p UFP-specific transcription factor mRNA processing involved in endoplasmic reticulum unfolded protein response|fungal-type cell wall organization|peroxisome degradation|cell morphogenesis involved in conjugation|response to acid|response to osmotic stress transmembrane signaling receptor activity integral to plasma membrane|mating projection tip
YER084W_p YER084W YER084W hom Uncharacterized 2.2725397358279 0.01152696541409 no 123 0.0158491779813213 150 NA Protein of unknown function; expressed at both mRNA and protein levels biological_process molecular_function cellular_component
YBL100W-C_p YBL100W-C YBL100W-C hom Uncharacterized 2.27049232347207 0.0115888642681175 no 124 0.0105480720278319 94 NA Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching biological_process molecular_function cellular_component
YGR092W YGR092W DBF2 hom Verified 2.25949594856453 0.0119262760204107 no 125 0.0364886942768881 230 NA FF|FT CELL CYCLE|ION HOMEOSTASIS|PROTEIN PHOSPHORYLATION|ION HOMEOSTASIS SITE OF POLARIZED GROWTH|CYTOSKELETON Ser/Thr kinase involved in transcription and stress response; functions as part of a network of genes in exit from mitosis; localization is cell cycle regulated; activated by Cdc15p during the exit from mitosis; also plays a role in regulating the stability of SWI5 and CLB2 mRNAs; phosphorylates Chs2p to regulate primary septum formation and Hof1p to regulate cytokinesis nuclear division|protein phosphorylation|vacuolar acidification protein serine/threonine kinase activity|protein kinase activity spindle pole body|cellular bud neck
YHR163W YHR163W SOL3 hom Verified 2.25105482307935 0.012191032642119 no 126 0.010569506067265 122 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS NUCLEUS 6-phosphogluconolactonase; catalyzes the second step of the pentose phosphate pathway; weak multicopy suppressor of los1-1 mutation; homologous to Sol2p and Sol1p; SOL3 has a paralog, SOL4, that arose from the whole genome duplication pentose-phosphate shunt, oxidative branch 6-phosphogluconolactonase activity nucleus|cytoplasm
YBL052C YBL052C SAS3 hom Verified 2.24317819566561 0.0124426628874831 no 127 0.0173589182319348 141 NA FT CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS HISTONE ACETYLTRANSFERASE Histone acetyltransferase catalytic subunit of NuA3 complex that acetylates histone H3, involved in transcriptional silencing; homolog of the mammalian MOZ proto-oncogene; mutant has aneuploidy tolerance; sas3gcn5 double mutation is lethal histone acetylation|chromatin modification|chromatin silencing at telomere|chromatin silencing at silent mating-type cassette histone acetyltransferase activity NuA3 histone acetyltransferase complex
YNL233W YNL233W BNI4 hom Verified 2.24300936848108 0.0124481051900051 no 128 0.0224908171825056 142 NA FT PROTEIN LOCALIZATION|CELL DIVISION|CARBOHYDRATE METABOLISM SITE OF POLARIZED GROWTH|CYTOSKELETON Targeting subunit for Glc7p protein phosphatase, localized to the bud neck, required for localization of chitin synthase III to the bud neck via interaction with the chitin synthase III regulatory subunit Skt5p asymmetric protein localization|barrier septum assembly|chitin biosynthetic process protein binding incipient cellular bud site|cellular bud neck septin collar|cellular bud neck|septin ring
YER188W_d YER188W YER188W hom Dubious 2.24129630878158 0.0125034439535868 no 129 0.0178610469148158 119 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; large-scale analyses show mRNA expression increases under anaerobic conditions and two-hybrid interactions with Sst2p Unknown Unknown Unknown
YGR135W YGR135W PRE9 hom Verified 2.23062804758344 0.0128528886703635 no 130 0.0133493056261498 112 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION Alpha 3 subunit of the 20S proteasome, the only nonessential 20S subunit; may be replaced by the alpha 4 subunit (Pre6p) under stress conditions to create a more active proteasomal isoform proteasomal ubiquitin-dependent protein catabolic process|proteasome core complex assembly|proteasomal ubiquitin-independent protein catabolic process molecular_function mitochondrion|proteasome core complex, alpha-subunit complex|proteasome storage granule|nucleus|nuclear outer membrane-endoplasmic reticulum membrane network
YGL005C YGL005C COG7 hom Verified 2.22960959516848 0.0128866861480032 no 131 0.12969942527469 506 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM|MITOCHONDRION|GOLGI APPARATUS Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments intra-Golgi vesicle-mediated transport|CVT pathway molecular_function mitochondrion|Golgi transport complex
YPR027C_p YPR027C YPR027C hom Uncharacterized 2.2281609215665 0.0129348929786557 no 132 0.0218447589047702 172 NA Putative protein of unknown function biological_process molecular_function cellular_component
YBR203W YBR203W COS111 hom Verified 2.21834458281018 0.0132656732736564 no 133 0.0235494142642001 125 NA FT SIGNALING MITOCHONDRION Protein required for resistance to the antifungal drug ciclopirox olamine; not related to the subtelomerically-encoded COS family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies signal transduction molecular_function mitochondrion
YDR149C_d YDR149C YDR149C hom Dubious 2.21791158736708 0.0132804306433818 no 134 0.0124220792961947 147 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene NUM1; null mutation blocks anaerobic growth Unknown Unknown Unknown
YPL161C YPL161C BEM4 hom Verified 2.21371867256546 0.0134240688111437 no 135 0.0525625602732817 287 NA FF|FT SIGNALING|CYTOSKELETON ORGANIZATION NUCLEUS Protein involved in establishment of cell polarity and bud emergence; interacts with the Rho1p small GTP-binding protein and with the Rho-type GTPase Cdc42p; involved in maintenance of proper telomere length establishment of cell polarity|Rho protein signal transduction|actin cytoskeleton organization molecular_function nucleus|cytoplasm
YAL002W YAL002W VPS8 hom Verified 2.1959151108871 0.0140490099752052 no 136 0.0164002556595822 167 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT GOLGI APPARATUS Membrane-binding component of the CORVET complex; involved in endosomal vesicle tethering and fusion in the endosome to vacuole protein targeting pathway; interacts with Vps21p; contains RING finger motif late endosome to vacuole transport via multivesicular body sorting pathway|protein targeting to vacuole GTPase binding|protein anchor late endosome|membrane|CORVET complex
YJR104C YJR104C SOD1 hom Verified 2.17925727633226 0.0146562805715298 no 137 0.079839694085741 390 NA FF|FT ION HOMEOSTASIS|CELL WALL ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|RESPONSE TO OXIDATIVE STRESS NUCLEUS|MITOCHONDRION Cytosolic copper-zinc superoxide dismutase; some mutations are analogous to those that cause ALS (amyotrophic lateral sclerosis) in humans; protein abundance increases in response to DNA replication stress and in response to prolonged exposure to boric acid cellular copper ion homeostasis|fungal-type cell wall organization|superoxide metabolic process|cellular zinc ion homeostasis|positive regulation of sequence-specific DNA binding transcription factor activity|age-dependent response to reactive oxygen species involved in chronological cell aging superoxide dismutase activity cytosol|mitochondrion|nucleus|mitochondrial intermembrane space
YMR196W_p YMR196W YMR196W hom Uncharacterized 2.16973625971927 0.0150134157500211 no 138 0.0233318479397961 178 NA FT CARBOHYDRATE METABOLISM Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR196W is not an essential gene biological_process molecular_function cytoplasm
YNR057C YNR057C BIO4 hom Verified 2.16936757264026 0.0150273944115336 no 139 0.0203079773304275 150 NA FT KETONE METABOLISM|COFACTOR METABOLISM Dethiobiotin synthetase, catalyzes the third step in the biotin biosynthesis pathway; BIO4 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis; expression appears to be repressed at low iron levels biotin biosynthetic process dethiobiotin synthase activity cytoplasm
YHR032W YHR032W ERC1 hom Verified 2.15573980465107 0.0155519940838065 no 140 0.0174402399947578 113 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM Member of the multi-drug and toxin extrusion (MATE) family of the multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter superfamily; overproduction confers ethionine resistance and accumulation of S-adenosylmethionine S-adenosylmethionine biosynthetic process|transmembrane transport antiporter activity integral to membrane
YDL135C YDL135C RDI1 hom Verified 2.15561737169816 0.0155567774759022 no 141 0.00593827740011581 58 NA FT MEMBRANE ORGANIZATION|SIGNALING|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH Rho GDP dissociation inhibitor; involved in the localization and regulation of Cdc42p and Rho1p; protein abundance increases in response to DNA replication stress regulation of vacuole fusion, non-autophagic|actin filament organization|small GTPase mediated signal transduction Rho GDP-dissociation inhibitor activity cytosol|plasma membrane|cellular bud neck|cellular bud tip
YJL080C YJL080C SCP160 hom Verified 2.15104449473215 0.0157363439377611 no 142 0.0132342345889413 150 NA FT CELL CYCLE|SIGNALING|RNA LOCALIZATION|CHROMOSOME SEGREGATION|GENE SILENCING ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM Essential RNA-binding G protein effector of mating response pathway, mainly associated with nuclear envelope and ER, interacts in mRNA-dependent manner with translating ribosomes via multiple KH domains, similar to vertebrate vigilins meiotic telomere clustering|pheromone-dependent signal transduction involved in conjugation with cellular fusion|chromosome segregation|intracellular mRNA localization|chromatin silencing at silent mating-type cassette|chromatin silencing at telomere G-protein alpha-subunit binding|RNA binding endoplasmic reticulum membrane|polysome|nuclear outer membrane-endoplasmic reticulum membrane network
YLR269C_d YLR269C YLR269C hom Dubious 2.14238169997485 0.0160813896329485 no 143 0.0142464210083758 79 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YEL016C YEL016C NPP2 hom Verified 2.14104061776194 0.0161353813463978 no 144 0.0177253618015177 100 NA FT NUCLEOTIDE METABOLISM Nucleotide pyrophosphatase/phosphodiesterase; mediates extracellular nucleotide phosphate hydrolysis along with Npp1p and Pho5p; activity and expression enhanced during conditions of phosphate starvation; NPP2 has a paralog, NPP1, that arose from the whole genome duplication nucleoside triphosphate metabolic process nucleotide diphosphatase activity|nucleoside-triphosphate diphosphatase activity|nucleoside-triphosphatase activity|phosphodiesterase I activity cellular_component
YHR207C YHR207C SET5 hom Verified 2.13756539442409 0.0162760164497566 no 145 0.0188551188698053 159 NA FT CHROMATIN ORGANIZATION NUCLEUS|CHROMOSOME Methyltransferase involved in methylation of histone H4 Lys5, -8, -12; S-adenosylmethionine-dependent; zinc-finger protein, contains one canonical and two unusual fingers in unusual arrangements; deletion enhances replication of positive-strand RNA virus histone lysine methylation S-adenosylmethionine-dependent methyltransferase activity nuclear chromatin|nucleus|cytoplasm
YKL155C YKL155C RSM22 hom Verified 2.13658542404004 0.0163158630986227 no 146 0.0176247824403096 122 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the small subunit; also predicted to be an S-adenosylmethionine-dependent methyltransferase mitochondrial translation structural constituent of ribosome|S-adenosylmethionine-dependent methyltransferase activity mitochondrion|mitochondrial small ribosomal subunit
YLL014W YLL014W EMC6 hom Verified 2.13520592723032 0.016372096485984 no 147 0.0251121248666647 168 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm F33D4.7/EMC-6, fly CG11781, human TMEM93 protein folding in endoplasmic reticulum molecular_function ER membrane protein complex|integral to membrane|endoplasmic reticulum
YLR402W_d YLR402W YLR402W hom Dubious 2.13062071813016 0.0165602006632787 no 148 0.0218459029995231 90 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YLR148W YLR148W PEP3 hom Verified 2.13057606016962 0.0165620417744709 no 149 0.0567391362279546 298 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT Component of CORVET tethering complex; vacuolar peripheral membrane protein that promotes vesicular docking/fusion reactions in conjunction with SNARE proteins, required for vacuolar biogenesis regulation of SNARE complex assembly|regulation of vacuole fusion, non-autophagic|vacuole fusion, non-autophagic|late endosome to vacuole transport|vesicle docking involved in exocytosis|Golgi to endosome transport phosphatidylinositol binding|protein binding, bridging fungal-type vacuole membrane|HOPS complex|proteasome storage granule|CORVET complex|extrinsic to vacuolar membrane
YGR126W_p YGR126W YGR126W hom Uncharacterized 2.12614936661789 0.0167454122635657 no 150 0.0122522755070284 107 NA FT NUCLEUS Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS biological_process molecular_function nucleus|cytoplasm
YLL038C YLL038C ENT4 hom Verified 2.12057197280677 0.0169789193989382 no 151 0.00365868832170595 52 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION CYTOSKELETON Protein of unknown function, contains an N-terminal epsin-like domain; proposed to be involved in the trafficking of Arn1p in the absence of ferrichrome endocytosis|actin filament organization|establishment of protein localization to plasma membrane|actin cortical patch assembly clathrin binding actin cortical patch
YHR026W YHR026W VMA16 hom Verified 2.11773466450949 0.0170987726807066 no 152 0.0572839237733885 258 NA FF|FT ION HOMEOSTASIS|ION HOMEOSTASIS Subunit c'' of the vacuolar ATPase, which functions in acidification of the vacuole; one of three proteolipid subunits of the V0 domain vacuolar acidification proton-transporting ATPase activity, rotational mechanism vacuolar proton-transporting V-type ATPase, V0 domain|integral to membrane
YNL162W-A_p YNL162W-A YNL162W-A hom Uncharacterized 2.11322131378339 0.0172909149275327 no 153 0.0138129114951867 127 NA FT NUCLEUS Putative protein of unknown function; identified by homology biological_process molecular_function nucleus|cytoplasm
YER186C_p YER186C YER186C hom Uncharacterized 2.09682198220162 0.0180046684532464 no 154 0.0189990636810349 148 NA Putative protein of unknown function biological_process molecular_function cellular_component
YOL002C YOL002C IZH2 hom Verified 2.09519979752975 0.0180766176375475 no 155 0.016210258197819 157 NA FT KETONE METABOLISM|LIPID METABOLISM|ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE Plasma membrane protein involved in zinc homeostasis and osmotin-induced apoptosis; transcription regulated by Zap1p, zinc and fatty acid levels; similar to mammalian adiponectins; deletion increases sensitivity to elevated zinc response to zinc ion|cellular zinc ion homeostasis|response to toxin|cellular lipid metabolic process protein binding|metal ion binding integral to membrane|plasma membrane|membrane
YLR012C_p YLR012C YLR012C hom Uncharacterized 2.09114721467994 0.0182574346998945 no 156 0.0329945106013322 172 NA Putative protein of unknown function; YLR012C is not an essential gene biological_process molecular_function cellular_component
YNL304W YNL304W YPT11 hom Verified 2.08547057782687 0.0185133030844633 no 157 0.0201533683747317 104 NA FT SIGNALING|MITOCHONDRION ORGANIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|SITE OF POLARIZED GROWTH Rab family GTPase that interacts with the C-terminal tail domain of Myo2p; mediates distribution of mitochondria and endoplasmic reticuli to daughter cells mitochondrion inheritance|endoplasmic reticulum inheritance|Golgi inheritance|Golgi localization GTPase activity incipient cellular bud site|endoplasmic reticulum|cellular bud neck|cellular bud tip
YPR193C YPR193C HPA2 hom Verified 2.07627847952483 0.0189341012501114 no 158 0.0144966704800507 145 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CHROMATIN ORGANIZATION Tetrameric histone acetyltransferase with similarity to Gcn5p, Hat1p, Elp3p, and Hpa3p; acetylates histones H3 and H4 in vitro and exhibits autoacetylation activity protein homotetramerization|histone acetylation histone acetyltransferase activity|protein homodimerization activity cytoplasm
YOL159C YOL159C YOL159C hom Verified 2.07503386381111 0.0189916981938621 no 159 0.0103895550383757 103 NA Soluble protein of unknown function; deletion mutants are viable and have elevated levels of Ty1 retrotransposition and Ty1 cDNA biological_process molecular_function cellular_component
YBR224W_d YBR224W YBR224W hom Dubious 2.07423536592191 0.0190287286045734 no 160 0.0131492459733681 102 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene TDP1 Unknown Unknown Unknown
YJL047C YJL047C RTT101 hom Verified 2.06706750196984 0.0193638969062887 no 161 0.029887812333216 218 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|PROTEOLYSIS NUCLEUS UBIQUITIN LIGASE COMPLEX Cullin subunit of a Roc1p-dependent E3 ubiquitin ligase complex with a role in anaphase progression; implicated in Mms22-dependent DNA repair; involved with Mms1p in nonfunctional rRNA decay; modified by the ubiquitin-like protein, Rub1p replication fork processing|negative regulation of transposition, RNA-mediated|regulation of mitosis|nonfunctional rRNA decay|ubiquitin-dependent protein catabolic process ubiquitin-protein ligase activity Cul8-RING ubiquitin ligase complex|nucleus|cytoplasm
YCL047C YCL047C POF1 hom Verified 2.05484910936597 0.0199467905757702 no 162 0.0263435789847082 157 NA FT PROTEOLYSIS ATPase involved in the protein quality control and filamentation pathways; interacts physically with Kss1p and suppresses the filamentation defect of a kss1 deletion; also interacts with Ubc7p pseudohyphal growth|ER-associated protein catabolic process|invasive growth in response to glucose limitation ATPase activity cellular_component
YMR179W YMR179W SPT21 hom Verified 2.05462213837826 0.0199577578353597 no 163 0.0242650740828562 180 NA FT TRANSCRIPTION FROM RNA POL II|GENE SILENCING NUCLEUS Protein with a role in transcriptional silencing; required for normal transcription at several loci including HTA2-HTB2 and HHF2-HHT2, but not required at the other histone loci; functionally related to Spt10p; localizes to nuclear foci that become diffuse upon DNA replication stress chromatin silencing at rDNA|regulation of transcription from RNA polymerase II promoter|chromatin silencing at telomere|chromatin silencing at silent mating-type cassette molecular_function nucleus
YBR288C YBR288C APM3 hom Verified 2.05051462766091 0.0201571189249746 no 164 0.0315610362972598 215 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Mu3-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway Golgi to vacuole transport|vesicle-mediated transport molecular_function AP-3 adaptor complex
YOR163W YOR163W DDP1 hom Verified 2.03818912864763 0.0207655111475104 no 165 0.0143064157383892 110 NA FT CARBOHYDRATE METABOLISM NUCLEUS Polyphosphate phosphatase; hydrolyzes diphosphorylated inositol polyphosphates and diadenosine polyphosphates; high specificity for diadenosine hexa- and pentaphosphates; contains endopolyphosphatase activity with a high affinity for polyphosphates, an activity also observed for its human DIPP homologs; possesses mRNA decapping activity; nudix hydrolase family member; protein abundance increases in response to DNA replication stress polyphosphate catabolic process|inositol phosphate dephosphorylation|diadenosine polyphosphate catabolic process diphosphoinositol-polyphosphate diphosphatase activity|endopolyphosphatase activity|bis(5'-adenosyl)-pentaphosphatase activity|bis(5'-adenosyl)-hexaphosphatase activity nucleus|cytoplasm
YFL027C YFL027C GYP8 hom Verified 2.03434831822938 0.0209582443599117 no 166 0.0175709378321699 103 NA FT VESICLE-MEDIATED TRANSPORT|SIGNALING|NUCLEOTIDE METABOLISM GTPase-activating protein for yeast Rab family members; Ypt1p is the preferred in vitro substrate but also acts on Sec4p, Ypt31p and Ypt32p; involved in the regulation of ER to Golgi vesicle transport vesicle-mediated transport Rab GTPase activator activity intracellular
YPL066W YPL066W RGL1 hom Verified 2.03404177401259 0.0209736918841159 no 167 0.0424624673082009 271 NA FF|FT SITE OF POLARIZED GROWTH Regulator of Rho1p signaling, cofactor of Tus1p; required for the localization of Tus1p during all phases of cytokinesis; green fluorescent protein (GFP)-fusion protein localizes to the bud neck and cytoplasm; null mutant is viable and exhibits growth defect on a non-fermentable (respiratory) carbon source protein localization to bud neck molecular_function cellular bud neck|cytoplasm
YKL204W YKL204W EAP1 hom Verified 2.03244515484483 0.0210543053704183 no 168 0.0348503783788244 184 NA FT TRANSLATION eIF4E-associated protein, competes with eIF4G for binding to eIF4E; accelerates mRNA degradation by promoting decapping, facilitated by interaction with eIF4E; essential for Puf5p mediated repression; associates with Puf5p and Dhh1p; inhibits cap-dependent translation; functions independently of eIF4E to maintain genetic stability; plays a role in cell growth, implicated in the TOR signaling cascade negative regulation of translation eukaryotic initiation factor 4E binding mRNA cap binding complex|cytoplasmic stress granule
YPR131C YPR131C NAT3 hom Verified 2.03050213690763 0.0211527620896312 no 169 0.0203120757216979 145 NA FT MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION Catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes acetylation of the amino-terminal methionine residues of all proteins beginning with Met-Asp or Met-Glu and of some proteins beginning with Met-Asn or Met-Met mitochondrion inheritance|N-terminal peptidyl-methionine acetylation|cytoskeleton organization peptide alpha-N-acetyltransferase activity NatB complex|cytoplasm
YBR285W_p YBR285W YBR285W hom Uncharacterized 2.02273065152465 0.0215504624567732 no 170 0.0316866337317111 157 NA Putative protein of unknown function; YBR285W is not an essential gene biological_process molecular_function cellular_component
YCL016C YCL016C DCC1 hom Verified 2.01941542531339 0.0217220298074983 no 171 0.0373900439313518 215 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION CHROMOSOME Subunit of a complex with Ctf8p and Ctf18p that shares some components with Replication Factor C, required for sister chromatid cohesion and telomere length maintenance maintenance of DNA trinucleotide repeats|response to DNA damage stimulus|mitotic sister chromatid cohesion molecular_function Ctf18 RFC-like complex
YML113W YML113W DAT1 hom Verified 2.01738683623948 0.0218275799605585 no 172 0.0160396294116247 110 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS DNA binding protein that recognizes oligo(dA).oligo(dT) tracts; Arg side chain in its N-terminal pentad Gly-Arg-Lys-Pro-Gly repeat is required for DNA-binding; not essential for viability negative regulation of transcription from RNA polymerase II promoter AT DNA binding nucleus
YLR311C_d YLR311C YLR311C hom Dubious 2.0158351928336 0.0219086060903402 no 173 0.0240312881561142 125 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YER090W YER090W TRP2 hom Verified 2.0144758005022 0.0219798015415115 no 174 0.210340473187331 807 NA FF|FT KETONE METABOLISM|AMINO ACID METABOLISM Anthranilate synthase, catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p tryptophan biosynthetic process anthranilate synthase activity anthranilate synthase complex|cytoplasm
YBR025C YBR025C OLA1 hom Verified 2.01095940626937 0.0221648723205159 no 175 0.023044826051017 146 NA P-loop ATPase with similarity to human OLA1 and bacterial YchF; identified as specifically interacting with the proteasome; protein abundance increases in response to hydrogen peroxide and to DNA replication stress biological_process ATPase activity cytoplasm
YJL056C YJL056C ZAP1 hom Verified 2.00920480871457 0.0222577089813133 no 176 0.0629705330026301 268 NA FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS NUCLEUS Zinc-regulated transcription factor; binds to zinc-responsive promoters to induce transcription of certain genes in presence of zinc, represses other genes in low zinc; regulates its own transcription; contains seven zinc-finger domains regulation of transcription from RNA polymerase II promoter in response to zinc ion starvation|positive regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding RNA polymerase II transcription factor activity|RNA polymerase II regulatory region sequence-specific DNA binding|zinc ion binding nucleus
YDR197W YDR197W CBS2 hom Verified 2.00863087785994 0.022288147077402 no 177 0.0404609440138744 171 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial translational activator of the COB mRNA; interacts with translating ribosomes, acts on the COB mRNA 5'-untranslated leader mitochondrial respiratory chain complex III biogenesis|positive regulation of mitochondrial translation translation regulator activity mitochondrion|extrinsic to mitochondrial inner membrane|mitochondrial ribosome
YPL267W YPL267W ACM1 hom Verified 2.00493948877814 0.0224847582255171 no 178 0.0294325854164611 183 NA FT CELL CYCLE|CELL DIVISION NUCLEUS Pseudosubstrate inhibitor of the anaphase-promoting complex/cyclosome (APC/C), that suppresses APC/C [Cdh1]-mediated proteolysis of mitotic cyclins; associates with Cdh1p, Bmh1p and Bmh2p; cell cycle regulated protein negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle ubiquitin-protein ligase inhibitor activity nucleus|cytoplasm
YBL060W YBL060W YEL1 hom Verified 2.00448123339366 0.0225092676156298 no 179 0.0266340866915683 165 NA FT PROTEIN LOCALIZATION|LIPID METABOLISM|SIGNALING SITE OF POLARIZED GROWTH|PLASMA MEMBRANE Guanine nucleotide exchange factor specific for Arf3p; localized to the bud neck and tip; required for localization of Arf3p to the bud neck and tip positive regulation of phosphatidylinositol biosynthetic process|protein localization|actin cortical patch localization ARF guanyl-nucleotide exchange factor activity cellular bud neck|cellular bud tip|cytoplasm
YLR350W YLR350W ORM2 hom Verified 1.99697173676239 0.0229141266748695 no 180 0.0277416042225642 220 NA FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Evolutionarily conserved protein, similar to Orm1p; required for resistance to agents that induce unfolded protein response; Orm1p and Orm2p together control membrane biogenesis by coordinating lipid homeostasis with protein quality control; protein abundance increases in response to DNA replication stress cellular sphingolipid homeostasis|negative regulation of sphingolipid biosynthetic process|response to unfolded protein molecular_function integral to membrane|endoplasmic reticulum|SPOTS complex
YDR417C_d YDR417C YDR417C hom Dubious 1.99579430216335 0.0229781586353481 no 181 0.027121418025819 134 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RPL12B/YDR418W Unknown Unknown Unknown
YOL086W-A YOL086W-A MHF1 hom Verified 1.99195038154502 0.0231882511458602 no 182 0.0104667345659657 94 NA FT RESPONSE TO DNA DAMAGE Component of the heterotetrameric MHF histone-fold complex; in humans the MMF complex interacts with both DNA and Mph1p ortholog FANCM, a Fanconi anemia complementation group protein, to stabilize and remodel blocked replication forks and repair damaged DNA; mhf1 srs2 double mutants are MMS hypersensitive; ortholog of human centromere constitutive-associated network (CCAN) subunit CENP-S, also known as MHF1 response to DNA damage stimulus molecular_function cellular_component
YBR277C_d YBR277C YBR277C hom Dubious 1.990506356646 0.0232675922298717 no 183 0.0239282367073042 184 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR278W Unknown Unknown Unknown
YML123C YML123C PHO84 hom Verified 1.98943785545929 0.0233264473775798 no 184 0.0493914241426772 270 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE High-affinity inorganic phosphate (Pi) transporter and low-affinity manganese transporter; regulated by Pho4p and Spt7p; mutation confers resistance to arsenate; exit from the ER during maturation requires Pho86p; cells overexpressing Pho84p accumulate heavy metals but do not develop symptoms of metal toxicity phosphate ion transport|manganese ion transport|polyphosphate metabolic process manganese ion transmembrane transporter activity|inorganic phosphate transmembrane transporter activity integral to membrane|integral to plasma membrane
YDL088C YDL088C ASM4 hom Verified 1.9858422494916 0.0235254214210928 no 185 0.0224607678076091 156 NA FT PROTEIN LOCALIZATION|CELL CYCLE|CELL DIVISION|RNA LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS NUCLEAR PORE FG-nucleoporin component of central core of nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport; induces membrane tubulation, which may contribute to nuclear pore assembly; ASM4 has a paralog, NUP53, that arose from the whole genome duplication nuclear pore organization|mRNA export from nucleus in response to heat stress|mitotic cell cycle spindle assembly checkpoint nucleocytoplasmic transporter activity|phospholipid binding|single-stranded DNA binding nuclear pore central transport channel|integral to membrane|nuclear pore
YNL096C YNL096C RPS7B hom Verified 1.98397330653728 0.0236294078850073 no 186 0.030585766799738 211 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION NUCLEUS RIBOSOME Protein component of the small (40S) ribosomal subunit; interacts with Kti11p; deletion causes hypersensitivity to zymocin; homologous to mammalian ribosomal protein S7, no bacterial homolog; RPS7B has a paralog, RPS7A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress cytoplasmic translation|ribosome biogenesis structural constituent of ribosome small-subunit processome|cytosolic small ribosomal subunit
YPL260W YPL260W YPL260W hom Verified 1.98260799232669 0.0237056169688877 no 187 0.035350428405379 191 NA FT NUCLEUS Putative substrate of cAMP-dependent protein kinase (PKA); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YPL260W is not an essential gene; protein abundance increases in response to DNA replication stress biological_process molecular_function nucleus|cytoplasm
YJR060W YJR060W CBF1 hom Verified 1.97876721333116 0.0239211107523135 no 188 0.0423037865909287 260 NA FF|FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|LIPID METABOLISM|AMINO ACID METABOLISM|CHROMATIN ORGANIZATION|RESPONSE TO NUTRIENT LEVELS|CHROMOSOME SEGREGATION NUCLEUS|MITOCHONDRION|CHROMOSOME KINETOCHORE Dual function helix-loop-helix protein; binds the motif CACRTG present at several sites including MET gene promoters and centromere DNA element I (CDEI); affects nucleosome positioning at this motif; associates with other transcription factors such as Met4p and Isw1p to mediate transcriptional activation or repression; associates with kinetochore proteins and required for efficient chromosome segregation; protein abundance increases in response to DNA replication stress regulation of transcription from RNA polymerase II promoter in response to methionine|negative regulation of transcription from RNA polymerase II promoter|methionine biosynthetic process|chromosome segregation|Unknown|chromatin remodeling|negative regulation of ceramide biosynthetic process by negative regulation of transcription from RNA Polymerase II promoter RNA polymerase II activating transcription factor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II transcription factor binding transcription factor activity|RNA polymerase II repressing transcription factor binding|centromeric DNA binding chromosome, centromeric region|mitochondrion|nucleus|kinetochore
YMR204C YMR204C INP1 hom Verified 1.97452331289006 0.0241611346377543 no 189 0.0198425261763672 118 NA FT PEROXISOME ORGANIZATION Peripheral membrane protein of peroxisomes involved in peroxisomal inheritance; recruitment to peroxisomes is mediated by interaction with Pex3p at the peroxisomal membrane peroxisome inheritance molecular_function peroxisome|extrinsic to intraperoxisomal membrane
YML067C YML067C ERV41 hom Verified 1.96620116488648 0.0246376889900295 no 190 0.024873494781303 135 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS Protein localized to COPII-coated vesicles, forms a complex with Erv46p; involved in the membrane fusion stage of transport; has homology to human ERGIC2 (PTX1) protein ER to Golgi vesicle-mediated transport molecular_function integral to endoplasmic reticulum membrane|integral to Golgi membrane|ER to Golgi transport vesicle
YIR020W-A_d YIR020W-A YIR020W-A hom Dubious 1.96554195640846 0.0246757722898745 no 191 0.0296638991394939 164 NA Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data Unknown Unknown Unknown
YFR033C YFR033C QCR6 hom Verified 1.96471853890237 0.024723411514677 no 192 0.0226866724572869 187 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Subunit 6 of the ubiquinol cytochrome-c reductase complex; the complex, also known as the cytochrome bc(1) complex or Complex III, is a component of the mitochondrial inner membrane electron transport chain; highly acidic protein; required for maturation of cytochrome c1; may be loosely associated with the complex since it is easily released into the intermembrane space mitochondrial electron transport, ubiquinol to cytochrome c|aerobic respiration ubiquinol-cytochrome-c reductase activity mitochondrion|integral to membrane|mitochondrial respiratory chain complex III
YAL053W YAL053W FLC2 hom Verified 1.95736314855952 0.0251523939563631 no 193 0.0363228131676723 186 NA FT CELL WALL ORG/BIOGENESIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance; FLC2 has a paralog, YOR365C, that arose from the whole genome duplication protein folding|fungal-type cell wall biogenesis|FAD transport|transmembrane transport FAD transmembrane transporter activity integral to membrane|endoplasmic reticulum|cytoplasm
YEL033W_p YEL033W MTC7 hom Uncharacterized 1.95448012181839 0.0253222317279987 no 194 0.0460152494162721 237 NA Predicted metabolic role based on network analysis derived from ChIP experiments, a large-scale deletion study and localization of transcription factor binding sites; null mutant is sensitive to temperature oscillation in a cdc13-1 mutant biological_process molecular_function cellular_component
YOL152W YOL152W FRE7 hom Verified 1.95108541490771 0.0255234429584544 no 195 0.0263877320442912 145 NA FT ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|GEN. OF PRECURSOR METABOLITES AND ENERGY PLASMA MEMBRANE Putative ferric reductase with similarity to Fre2p; expression induced by low copper levels iron ion transport|copper ion import ferric-chelate reductase activity integral to membrane|plasma membrane
YER049W YER049W TPA1 hom Verified 1.9509273158236 0.0255328463507054 no 196 0.0144631701405591 84 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|OXIDATION-REDUCTION PROCESS NUCLEUS Poly(rA)-binding protein involved in translation termination efficiency, mRNA poly(A) tail length and mRNA stability; interacts with Sup45p (eRF1), Sup35p (eRF3) and Pab1p; similar to prolyl 4-hydroxylases; binds Fe(III) and 2-oxoglutarate nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|translational termination poly(A) RNA binding nucleus
YDR100W YDR100W TVP15 hom Verified 1.94774257966383 0.0257228862425125 no 197 0.0241506275190786 99 NA FT VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p vesicle-mediated transport molecular_function COPI-coated vesicle|integral to membrane|integral to Golgi membrane
YIL009C-A YIL009C-A EST3 hom Verified 1.94667545848861 0.0257868278272705 no 198 0.0317277334736991 172 NA FT NUCLEUS|CHROMOSOME Component of the telomerase holoenzyme, involved in telomere replication telomere maintenance via telomerase ATP-dependent DNA/RNA helicase activity|GTPase activity|telomeric DNA binding chromosome, telomeric region|nucleus|telomerase holoenzyme complex
YFL049W YFL049W SWP82 hom Verified 1.94267180635629 0.0260279124040662 no 199 0.0197665193558469 144 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION NUCLEUS RSC COMPLEX Member of the SWI/SNF chromatin remodeling complex; has an as yet unidentified role in the complex; has identifiable counterparts in closely related yeast species; abundantly expressed in many growth conditions; paralog of Npl6p; relocates to the cytosol under hypoxic conditions positive regulation of transcription from RNA polymerase II promoter molecular_function SWI/SNF complex|nucleus
YNL296W_d YNL296W YNL296W hom Dubious 1.93596722866475 0.0264358574002757 no 200 0.035652735396478 202 NA Dubious open reading frame unlikely to encode a functional protein; deletion adversely affects sporulation; deletion mutant exhibits synthetic phenotype under expression of mutant huntingtin fragment, but gene does not have human ortholog Unknown Unknown Unknown
YPL247C_p YPL247C YPL247C hom Uncharacterized 1.93420706260011 0.0265438371955671 no 201 0.0312723477167947 195 NA FT NUCLEUS Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; similar to the petunia WD repeat protein an11; overexpression causes a cell cycle delay or arrest biological_process molecular_function nucleus|cytoplasm
YGL152C_d YGL152C YGL152C hom Dubious 1.93318760408508 0.0266065456196889 no 202 0.032667971982259 96 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF PEX14/YGL153W Unknown Unknown Unknown
YGR292W YGR292W MAL12 hom Verified 1.92800563159764 0.0269272128499649 no 203 0.0130378302521482 66 NA FT CARBOHYDRATE METABOLISM Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL1 complex locus; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose sucrose catabolic process|maltose catabolic process sucrose alpha-glucosidase activity|maltose alpha-glucosidase activity plasma membrane
YGR257C YGR257C MTM1 hom Verified 1.92574063627456 0.0270683835762435 no 204 0.0493523339753551 280 NA FF|FT ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION Mitochondrial protein of the mitochondrial carrier family, involved in activating mitochondrial Sod2p probably by facilitating insertion of an essential manganese cofactor manganese ion transport|transport transporter activity|metallochaperone activity mitochondrion|integral to membrane|mitochondrial inner membrane
YBR293W YBR293W VBA2 hom Verified 1.92569400225853 0.0270712966188461 no 205 0.0259992949885197 200 NA Permease of basic amino acids in the vacuolar membrane basic amino acid transport|transmembrane transport basic amino acid transmembrane transporter activity|drug transmembrane transporter activity fungal-type vacuole membrane|integral to membrane
YJL135W_d YJL135W YJL135W hom Dubious 1.92362043906667 0.0272010885966294 no 206 0.0164707878979636 102 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL134W/LCB3 Unknown Unknown Unknown
YOL063C YOL063C CRT10 hom Verified 1.92359613025045 0.027202613248561 no 207 0.0215224961709114 148 NA FT TRANSCRIPTION FROM RNA POL II Protein involved in transcriptional regulation of RNR2 and RNR3; expression of the gene is induced by DNA damage and null mutations confer increased resistance to hydroxyurea; N-terminal region has a leucine repeat and a WD40 repeat regulation of transcription from RNA polymerase II promoter molecular_function cellular_component
YNL285W_d YNL285W YNL285W hom Dubious 1.91998128765631 0.0274301315323506 no 208 0.0256131210615613 129 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YPL181W YPL181W CTI6 hom Verified 1.91973432934772 0.0274457328285804 no 209 0.0370124341459175 214 NA FT CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS|CHROMOSOME Protein that relieves transcriptional repression by binding to the Cyc8p-Tup1p corepressor and recruiting the SAGA complex to the repressed promoter; contains a PHD finger domain negative regulation of chromatin silencing at silent mating-type cassette|positive regulation of transcription, DNA-dependent|regulation of DNA-dependent DNA replication initiation|negative regulation of chromatin silencing at telomere|negative regulation of chromatin silencing at rDNA methylated histone residue binding|transcription factor binding Rpd3L-Expanded complex|nucleus|Rpd3L complex
YGL148W YGL148W ARO2 hom Verified 1.91568224649436 0.0277027767761651 no 210 0.0867661518641256 423 NA FF|FT KETONE METABOLISM|AMINO ACID METABOLISM Bifunctional chorismate synthase and flavin reductase; catalyzes the conversion of 5-enolpyruvylshikimate 3-phosphate (EPSP) to form chorismate, which is a precursor to aromatic amino acids; protein abundance increases in response to DNA replication stress aromatic amino acid family biosynthetic process chorismate synthase activity|riboflavin reductase (NADPH) activity cytoplasm
YLR120C YLR120C YPS1 hom Verified 1.91548788526418 0.0277151563375538 no 211 0.0388206961447364 150 NA FT CELL WALL ORG/BIOGENESIS|PROTEOLYSIS PLASMA MEMBRANE Aspartic protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor fungal-type cell wall organization|protein processing aspartic-type endopeptidase activity fungal-type cell wall
YLR281C_p YLR281C YLR281C hom Uncharacterized 1.90938659184675 0.028106119583823 no 212 0.0207117430188817 128 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION MITOCHONDRION Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR281C is not an essential gene biological_process molecular_function mitochondrion
YKR087C YKR087C OMA1 hom Verified 1.89867669052232 0.0288034990695826 no 213 0.0302207795076973 201 NA FT PROTEOLYSIS MITOCHONDRION Metalloendopeptidase of the mitochondrial inner membrane; involved in turnover of membrane-embedded proteins; mediates degradation of Cox1p in coa2 mutant cells; member of a family of predicted membrane-bound metallopeptidases in prokaryotes and higher eukaryotes misfolded or incompletely synthesized protein catabolic process metalloendopeptidase activity mitochondrion|mitochondrial inner membrane
YGL211W YGL211W NCS6 hom Verified 1.89525543606688 0.0290292845110024 no 214 0.032454720421259 188 NA FT RNA PROCESSING MITOCHONDRION Protein required for thiolation of the uridine at the wobble position of Gln, Lys, and Glu tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae tRNA wobble position uridine thiolation|protein urmylation|tRNA wobble uridine modification tRNA binding cytosol|mitochondrion
YGL242C_p YGL242C YGL242C hom Uncharacterized 1.8828988472808 0.0298570387429096 no 215 0.0419444215099024 153 NA Putative protein of unknown function; deletion mutant is viable biological_process molecular_function cellular_component
YBR014C YBR014C GRX7 hom Verified 1.88061982054761 0.0300118267803611 no 216 0.0226801475783063 172 NA FT RESPONSE TO OXIDATIVE STRESS GOLGI APPARATUS Cis-golgi localized monothiol glutaredoxin; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; does not bind metal ions; GRX7 has a paralog, GRX6, that arose from the whole genome duplication cellular response to oxidative stress glutathione-disulfide reductase activity|protein homodimerization activity integral to membrane|Golgi apparatus|Golgi lumen|fungal-type vacuole|cis-Golgi network
YGR183C YGR183C QCR9 hom Verified 1.87610179234997 0.0303206518181254 no 217 0.0301245325158136 179 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex iron-sulfur cluster assembly|mitochondrial electron transport, ubiquinol to cytochrome c|aerobic respiration ubiquinol-cytochrome-c reductase activity mitochondrion|integral to membrane|mitochondrial respiratory chain complex III
YMR021C YMR021C MAC1 hom Verified 1.87460021693834 0.0304238716618067 no 218 0.122939096751397 532 NA FF|FT TRANSCRIPTION FROM RNA POL II|ION HOMEOSTASIS|ION HOMEOSTASIS NUCLEUS Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport cellular copper ion homeostasis|positive regulation of protein catabolic process|positive regulation of transcription from RNA polymerase II promoter core promoter proximal region DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus
YDR318W YDR318W MCM21 hom Verified 1.87338095882542 0.030507898740244 no 219 0.0467906302708236 245 NA FT CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME KINETOCHORE Component of the kinetochore sub-complex COMA; COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) bridges kinetochore subunits in contact with centromeric DNA with subunits bound to microtubules during kinetochore assembly; involved in minichromosome maintenance; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-O and fission yeast mal2 chromosome segregation|establishment of mitotic sister chromatid cohesion molecular_function COMA complex|condensed nuclear chromosome kinetochore
YER178W YER178W PDA1 hom Verified 1.86448867165709 0.0311265554794705 no 220 0.04168908247317 195 NA FT KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex, catalyzes the direct oxidative decarboxylation of pyruvate to acetyl-CoA; phosphorylated; regulated by glucose acetyl-CoA biosynthetic process from pyruvate pyruvate dehydrogenase (acetyl-transferring) activity mitochondrial nucleoid|mitochondrion|mitochondrial pyruvate dehydrogenase complex
YFR018C_p YFR018C YFR018C hom Uncharacterized 1.86426252555824 0.0311424233212448 no 221 0.0264926224928796 147 NA FT PROTEOLYSIS Putative protein of unknown function biological_process molecular_function cellular_component
YPL022W YPL022W RAD1 hom Verified 1.86036890258031 0.0314166756187261 no 222 0.0305682771508466 182 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION NUCLEUS Single-stranded DNA endonuclease (with Rad10p), cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human XPF protein mitotic recombination|meiotic mismatch repair|nucleotide-excision repair, DNA incision, 5'-to lesion|double-strand break repair via single-strand annealing, removal of nonhomologous ends|removal of nonhomologous ends single-stranded DNA binding|single-stranded DNA specific endodeoxyribonuclease activity nucleotide-excision repair factor 1 complex|nucleus
YLR329W YLR329W REC102 hom Verified 1.85972544596094 0.0314621900012384 no 223 0.039861505981892 165 NA FT CELL CYCLE NUCLEUS|CHROMOSOME Protein involved in early stages of meiotic recombination; required for chromosome synapsis; forms a complex with Rec104p and Spo11p necessary during the initiation of recombination meiotic DNA double-strand break formation|reciprocal meiotic recombination molecular_function condensed nuclear chromosome|nucleus
YPR008W YPR008W HAA1 hom Verified 1.85288674151712 0.0319492969274567 no 224 0.0267032212330302 143 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Transcriptional activator involved in adaptation to weak acid stress; activates transcription of TPO2, YRO2, and other genes encoding membrane stress proteins; HAA1 has a paralog, CUP2, that arose from the whole genome duplication; relocalizes from cytoplasm to nucleus upon DNA replication stress response to acid|positive regulation of transcription from RNA polymerase II promoter in response to stress|positive regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding RNA polymerase II transcription factor activity nucleus
YMR302C YMR302C YME2 hom Verified 1.84582880816202 0.0324585331304971 no 225 0.0349994935337068 211 NA FT RNA PROCESSING|MITOCHONDRION ORGANIZATION MITOCHONDRION Integral inner mitochondrial membrane protein with a role in maintaining mitochondrial nucleoid structure and number; mutants exhibit an increased rate of mitochondrial DNA escape; shows some sequence similarity to exonucleases mitochondrial genome maintenance molecular_function mitochondrion|integral to mitochondrial inner membrane
YML026C YML026C RPS18B hom Verified 1.8444238024371 0.0325607005443157 no 226 0.0477591624974486 225 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION MITOCHONDRION RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S18 and bacterial S13; RPS18B has a paralog, RPS18A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress cytoplasmic translation|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|rRNA export from nucleus structural constituent of ribosome cytosolic small ribosomal subunit|mitochondrion
YLR028C YLR028C ADE16 hom Verified 1.83822619818122 0.0330145404477337 no 227 0.0265264206336125 103 NA FT OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY Enzyme of 'de novo' purine biosynthesis; contains both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities; ADE16 has a paralog, ADE17, that arose from the whole genome duplication; ade16 ade17 mutants require adenine and histidine ascospore formation|'de novo' IMP biosynthetic process|purine nucleotide biosynthetic process|aerobic respiration phosphoribosylaminoimidazolecarboxamide formyltransferase activity|IMP cyclohydrolase activity cytosol
YGR026W_p YGR026W YGR026W hom Uncharacterized 1.83683690706881 0.0331169878439747 no 228 0.0342998148769482 157 NA FT PLASMA MEMBRANE Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery biological_process molecular_function integral to membrane
YDR466W YDR466W PKH3 hom Verified 1.81370202382822 0.0348618066712932 no 229 0.0778331447674382 326 NA FF|FT SIGNALING|CELL WALL ORG/BIOGENESIS|PROTEIN PHOSPHORYLATION Protein kinase with similarity to mammalian phosphoinositide-dependent kinase 1 (PDK1) and yeast Pkh1p and Pkh2p, two redundant upstream activators of Pkc1p; identified as a multicopy suppressor of a pkh1 pkh2 double mutant MAPK cascade involved in cell wall biogenesis|protein phosphorylation protein kinase activity cellular_component
YNL010W_p YNL010W YNL010W hom Uncharacterized 1.81369712220798 0.034862184193535 no 230 0.0401049080055578 225 NA FT NUCLEUS Putative protein of unknown function with similarity to phosphoserine phosphatases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; homozygous diploid mutant shows an increase in glycogen accumulation biological_process molecular_function nucleus|cytoplasm
YDL010W YDL010W GRX6 hom Verified 1.80810278516612 0.0352952524018381 no 231 0.0328961771260862 152 NA FT RESPONSE TO OXIDATIVE STRESS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS Cis-golgi localized monothiol glutaredoxin, binds Fe-S cluster; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; GRX6 has a paralog, GRX7, that arose from the whole genome duplication cellular response to oxidative stress glutathione-disulfide reductase activity|iron ion binding|protein homodimerization activity|2 iron, 2 sulfur cluster binding integral to membrane|Golgi apparatus|Golgi lumen|endoplasmic reticulum membrane|fungal-type vacuole|cis-Golgi network
YFL047W YFL047W RGD2 hom Verified 1.80553983614803 0.0354951238292639 no 232 0.0367486033649967 194 NA FT SIGNALING SITE OF POLARIZED GROWTH GTPase-activating protein (RhoGAP) for Cdc42p and Rho5p; relocalizes from bud neck to cytoplasm upon DNA replication stress small GTPase mediated signal transduction Rho GTPase activator activity cellular bud neck|cytoplasm
YOR162C YOR162C YRR1 hom Verified 1.80331051570287 0.0356697310347519 no 233 0.0682342976376058 316 NA FF|FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO OXIDATIVE STRESS NUCLEUS Zn2-Cys6 zinc-finger transcription factor; activates genes involved in multidrug resistance; paralog of Yrm1p, acting on an overlapping set of target genes; YRR1 has a paralog, PDR8, that arose from the whole genome duplication regulation of transcription from RNA polymerase II promoter in response to oxidative stress|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity nucleus
YML096W_p YML096W YML096W hom Uncharacterized 1.79996205070809 0.0359333153178609 no 234 0.0485844176785548 223 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Putative protein of unknown function with similarity to asparagine synthetases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YML096W is not an essential gene and partially overlaps the verified gene RAD10 biological_process molecular_function cytoplasm
YER180C-A YER180C-A SLO1 hom Verified 1.79947776124659 0.0359715693284812 no 235 0.0470948925959506 266 NA FT PROTEIN LOCALIZATION Protein interacting with Arl3p, which is a GTPase of the Ras superfamily involved in vesicle-tethering at the Golgi; putative ortholog of human SCOCO intracellular protein transport small GTPase regulator activity cytoplasm
YOR155C YOR155C ISN1 hom Verified 1.79888535077702 0.0360184091683079 no 236 0.0330727358104879 111 NA FT NUCLEOTIDE METABOLISM Inosine 5'-monophosphate (IMP)-specific 5'-nucleotidase, catalyzes the breakdown of IMP to inosine, does not show similarity to known 5'-nucleotidases from other organisms nicotinamide riboside biosynthetic process|inosine salvage|nicotinic acid riboside biosynthetic process IMP 5'-nucleotidase activity cellular_component
YER007W YER007W PAC2 hom Verified 1.79746117941589 0.0361312178760634 no 237 0.0359702680221904 240 NA FT CYTOSKELETON Microtubule effector required for tubulin heterodimer formation, binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl protein folding|tubulin complex assembly|tubulin complex biogenesis alpha-tubulin binding cellular_component
YJL055W_p YJL055W YJL055W hom Uncharacterized 1.79608775334986 0.0362402809173662 no 238 0.0374257339046991 206 NA FT NUCLEUS Putative protein of unknown function, proposed to be involved in the metabolism of purine and pyrimidine base analogues; deletion mutants are sensitive to HAP and AHA; overexpression confers resistance to 5-FOA and 5-FU response to chemical stimulus|response to purine-containing compound molecular_function nucleus|cytoplasm
YGR015C_p YGR015C YGR015C hom Uncharacterized 1.7959727654759 0.0362494242578706 no 239 0.0437702343130466 169 NA FT MITOCHONDRION Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion biological_process molecular_function mitochondrion
YNL199C YNL199C GCR2 hom Verified 1.79048472389857 0.0366880104384058 no 240 0.0470927427092953 244 NA FT TRANSCRIPTION FROM RNA POL II|RIBOSOME BIOGENESIS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY ENDOMEMBRANE SYSTEM|NUCLEUS Transcriptional activator of genes involved in glycolysis; interacts and functions with the DNA-binding protein Gcr1p positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter|regulation of glycolysis by positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II activating transcription factor binding|RNA polymerase II transcription factor binding transcription factor activity nuclear envelope|nucleus
YDR048C_d YDR048C YDR048C hom Dubious 1.78532781031 0.0371040802358839 no 241 0.0356096401913526 129 NA Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YDR382W YDR382W RPP2B hom Verified 1.78441068166803 0.0371784783191425 no 242 0.0287382642304964 164 NA FT TRANSLATION RIBOSOME Ribosomal protein P2 beta, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm translational elongation|cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YKL118W_d YKL118W YKL118W hom Dubious 1.78162633941789 0.0374050931089519 no 243 0.0946292271302163 423 NA FF Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene VPH2 Unknown Unknown Unknown
YNL139C YNL139C THO2 hom Verified 1.77982795352397 0.0375520606848383 no 244 0.0600474953614626 252 NA FT TRANSCRIPTION FROM RNA POL II|RNA PROCESSING|RESPONSE TO DNA DAMAGE|RNA LOCALIZATION NUCLEUS Subunit of the THO complex, which is required for efficient transcription elongation and involved in transcriptional elongation-associated recombination; required for LacZ RNA expression from certain plasmids mRNA 3'-end processing|mRNA export from nucleus|transcription-coupled nucleotide-excision repair|DNA recombination|transcription elongation from RNA polymerase II promoter DNA binding|nucleic acid binding THO complex part of transcription export complex|nucleus|nucleoplasmic THO complex
YGL004C YGL004C RPN14 hom Verified 1.77752940202233 0.0377405888560942 no 245 0.0439192269872734 146 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS NUCLEUS Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasome regulatory particle (RP); null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; interacts with Rpt5p proteasome regulatory particle assembly|ubiquitin-dependent protein catabolic process molecular_function cytosol|nucleus|cytoplasm
YOR201C YOR201C MRM1 hom Verified 1.7761467052725 0.037854369900902 no 246 0.0445013787358812 254 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS MITOCHONDRION Ribose methyltransferase that modifies a functionally critical, conserved nucleotide in mitochondrial 21S rRNA rRNA modification rRNA (guanine-N1-)-methyltransferase activity mitochondrion
YKL091C YKL091C YKL091C hom Verified 1.77233129107511 0.0381697899585681 no 247 0.040254443858776 188 NA FT NUCLEUS Putative homolog of Sec14p, which is a phosphatidylinositol/phosphatidylcholine transfer protein involved in lipid metabolism; localizes to the nucleus; contains a CRAL/TRIO domain and binds several lipids in a large-scale study biological_process phosphatidylcholine binding|phosphatidylinositol transporter activity|phosphatidylinositol binding|phosphatidylcholine transporter activity nucleus
YFL016C YFL016C MDJ1 hom Verified 1.77072233460917 0.0383034432625144 no 248 0.0721734438723918 281 NA FT PROTEOLYSIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Co-chaperone that stimulates the ATPase activity of the HSP70 protein Ssc1p; involved in protein folding/refolding in the mitochodrial matrix; required for proteolysis of misfolded proteins; member of the HSP40 (DnaJ) family of chaperones protein refolding|response to heat|misfolded or incompletely synthesized protein catabolic process|mitochondrial genome maintenance|'de novo' protein folding unfolded protein binding|ATPase activator activity extrinsic to mitochondrial inner membrane|mitochondrion|mitochondrial matrix
YML063W YML063W RPS1B hom Verified 1.76917098867039 0.0384326720356517 no 249 0.048032981573167 219 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Ribosomal protein 10 (rp10) of the small (40S) subunit; homologous to mammalian ribosomal protein S3A, no bacterial homolog; RPS1B has a paralog, RPS1A, that arose from the whole genome duplication cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) structural constituent of ribosome cytosolic small ribosomal subunit|90S preribosome
YGR180C YGR180C RNR4 hom Verified 1.76458716787235 0.0388165868347118 no 250 0.0609208722953523 267 NA FT OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM NUCLEUS Ribonucleotide-diphosphate reductase (RNR) small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits; relocalizes from nucleus to cytoplasm upon DNA replication stress cofactor biosynthetic process|deoxyribonucleotide biosynthetic process ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor ribonucleoside-diphosphate reductase complex|nucleus|cytoplasm
YDR207C YDR207C UME6 hom Verified 1.76216527091439 0.0390206889667489 no 251 0.0994439231352357 422 NA FF|FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO NUTRIENT LEVELS NUCLEUS|CHROMOSOME Key transcriptional regulator of early meiotic genes, binds URS1 upstream regulatory sequence, couples metabolic responses to nutritional cues with initiation and progression of meiosis, forms complex with Ime1p, and also with Sin3p-Rpd3p spore germination|positive regulation of transcription from RNA polymerase II promoter during meiosis|negative regulation of transcription from RNA polymerase II promoter during meiosis|lipid particle organization|nitrogen catabolite repression of transcription from RNA polymerase II promoter|pseudohyphal growth|negative regulation of transcription from RNA polymerase II promoter during mitosis|Unknown RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|repressing transcription factor binding|transcription factor binding transcription factor activity Rpd3L-Expanded complex|Rpd3L complex
YAR018C YAR018C KIN3 hom Verified 1.7540031174743 0.0397149864847182 no 252 0.050530322099527 199 NA FT PROTEIN PHOSPHORYLATION|CHROMOSOME SEGREGATION Nonessential serine/threonine protein kinase; possible role in DNA damage response chromosome segregation|protein phosphorylation protein kinase activity cellular_component
YML048W YML048W GSF2 hom Verified 1.75151164353381 0.039928908715966 no 253 0.0658812591973647 331 NA FF|FT PROTEIN LOCALIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION ER localized integral membrane protein that may promote secretion of certain hexose transporters, including Gal2p; involved in glucose-dependent repression protein folding|protein localization to cell surface unfolded protein binding mitochondrial outer membrane|integral to endoplasmic reticulum membrane|cytoplasm
YPL029W YPL029W SUV3 hom Verified 1.75045038945094 0.0400203137805876 no 254 0.0876678980030746 357 NA FF|FT RNA PROCESSING|MITOCHONDRION ORGANIZATION MITOCHONDRION|CHROMOSOME ATP-dependent RNA helicase, component of the mitochondrial degradosome along with the RNase Dss1p; the degradosome associates with the ribosome and mediates RNA turnover; also required during splicing of the COX1 AI5_beta intron mitochondrial DNA replication|mitochondrial RNA catabolic process|Group I intron splicing exoribonuclease II activity|ATP-dependent RNA helicase activity mitochondrion|mitochondrial chromosome|mitochondrial degradosome
YAL040C YAL040C CLN3 hom Verified 1.75019117170101 0.0400426658408125 no 255 0.0366869373575247 230 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|MEMBRANE ORGANIZATION|CELL DIVISION|PROTEIN PHOSPHORYLATION NUCLEUS G1 cyclin involved in cell cycle progression; activates Cdc28p kinase to promote the G1 to S phase transition; plays a role in regulating transcription of the other G1 cyclins, CLN1 and CLN2; regulated by phosphorylation and proteolysis vacuole organization|regulation of cyclin-dependent protein kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|vacuole fusion, non-autophagic|regulation of cell size|G1/S transition of mitotic cell cycle cyclin-dependent protein kinase regulator activity nucleus
YEL043W YEL043W YEL043W hom Verified 1.74638561276147 0.0403719841249585 no 256 0.0394694652859826 221 NA FT ENDOPLASMIC RETICULUM Predicted cytoskeleton protein involved in intracellular signalling based on quantitative analysis of protein-protein interaction maps; may interact with ribosomes, based on co-purification studies; contains fibronectin type III domain fold biological_process molecular_function ribosome|endoplasmic reticulum
YPR020W YPR020W ATP20 hom Verified 1.74517200688531 0.0404774662002462 no 257 0.0385180107141296 216 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS MITOCHONDRION Subunit g of the mitochondrial F1F0 ATP synthase; reversibly phosphorylated on two residues; unphosphorylated form is required for dimerization of the ATP synthase complex protein oligomerization|cristae formation|protein complex assembly|ATP synthesis coupled proton transport structural molecule activity|proton-transporting ATPase activity, rotational mechanism mitochondrion|mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
YOR101W YOR101W RAS1 hom Verified 1.7409085972793 0.0408498007432279 no 258 0.0223568229926388 164 NA FT SIGNALING|NUCLEOTIDE METABOLISM PLASMA MEMBRANE GTPase involved in G-protein signaling in adenylate cyclase activation; plays a role in cell proliferation; localized to the plasma membrane; homolog of mammalian RAS proto-oncogenes; relative distribution to the nucleus increases upon DNA replication stress adenylate cyclase-activating G-protein coupled receptor signaling pathway|replicative cell aging|Ras protein signal transduction GTPase activity plasma membrane
YCR043C_p YCR043C YCR043C hom Uncharacterized 1.74028593802384 0.0409044109882649 no 259 0.0511122416018086 274 NA FT GOLGI APPARATUS|SITE OF POLARIZED GROWTH Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi apparatus; YCR043C is not an essential gene biological_process molecular_function Golgi apparatus|mating projection tip
YHR205W YHR205W SCH9 hom Verified 1.7402522708979 0.0409073654458 no 260 0.0322520379036748 187 NA FT PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|RIBOSOME BIOGENESIS|PROTEIN PHOSPHORYLATION|RESPONSE TO OXIDATIVE STRESS NUCLEUS|CHROMOSOME AGC family protein kinase; functional ortholog of mammalian S6 kinase; phosphorylated by Tor1p and required for TORC1-mediated regulation of ribosome biogenesis, translation initiation, and entry into G0 phase; involved in transactivation of osmostress-responsive genes; regulates G1 progression, cAPK activity and nitrogen activation of the FGM pathway; integrates nutrient signals and stress signals from sphingolipids to regulate lifespan protein phosphorylation|age-dependent response to oxidative stress involved in chronological cell aging|replicative cell aging|regulation of protein localization|positive regulation of transcription from RNA polymerase III promoter|positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase I promoter|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|regulation of cell size|regulation of response to osmotic stress protein serine/threonine kinase activity chromatin|fungal-type vacuole membrane|nucleus|cytoplasm
YDR535C_d YDR535C YDR535C hom Dubious 1.73527979928734 0.0413456290006162 no 261 0.054944665159867 273 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YDR535C is not an essential gene. Unknown Unknown Unknown
YDR297W YDR297W SUR2 hom Verified 1.73387123754626 0.0414704661320631 no 262 0.0506991115144694 243 NA FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Sphinganine C4-hydroxylase, catalyses the conversion of sphinganine to phytosphingosine in sphingolipid biosyntheis sphingolipid metabolic process sphingosine hydroxylase activity integral to membrane|endoplasmic reticulum membrane
YDR433W_d YDR433W YDR433W hom Dubious 1.73054804868094 0.0417662021916733 no 263 0.0544097246344833 320 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YDR485C YDR485C VPS72 hom Verified 1.72775376416467 0.0420161899753565 no 264 0.0823949906155192 407 NA FF|FT CHROMATIN ORGANIZATION NUCLEUS|CHROMOSOME Htz1p-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting chromatin remodeling|histone exchange histone binding Swr1 complex|nucleus|cytoplasm
YLR279W_d YLR279W YLR279W hom Dubious 1.72716327533122 0.0420691721617897 no 265 0.0570475997933676 275 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YIL133C YIL133C RPL16A hom Verified 1.72220469383908 0.0425162224347001 no 266 0.0482746045040588 250 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L16A; N-terminally acetylated, binds 5.8 S rRNA; transcriptionally regulated by Rap1p; homologous to mammalian ribosomal protein L13A and bacterial L13; RPL16A has a paralog, RPL16B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress cytoplasmic translation structural constituent of ribosome|RNA binding cytosolic large ribosomal subunit
YNL121C YNL121C TOM70 hom Verified 1.72059417742693 0.042662245388901 no 267 0.0821319946239145 340 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Component of the TOM (translocase of outer membrane) complex; involved in the recognition and initial import steps for all mitochondrially directed proteins; acts as a receptor for incoming precursor proteins; TOM70 has a paralog, TOM71, that arose from the whole genome duplication protein import into mitochondrial matrix|protein import into mitochondrial inner membrane mitochondrion targeting sequence binding|protein channel activity mitochondrial outer membrane|mitochondrion|integral to membrane|integral to mitochondrial outer membrane|mitochondrial outer membrane translocase complex
YDR162C YDR162C NBP2 hom Verified 1.71897346614266 0.0428096017503242 no 268 0.11186305163326 478 NA FF|FT PROTEIN PHOSPHORYLATION NUCLEUS Protein involved in the HOG (high osmolarity glycerol) pathway; negatively regulates Hog1p by recruitment of phosphatase Ptc1p the Pbs2p-Hog1p complex; interacts with Bck1p and down regulates the cell wall integrity pathway; found in the nucleus and cytoplasm, contains an SH3 domain and a Ptc1p binding domain (PBM) negative regulation of protein kinase activity|response to heat|hyperosmotic response molecular_function nucleus|cytoplasm
YML124C YML124C TUB3 hom Verified 1.71592465334391 0.043087916908198 no 269 0.104492669568234 477 NA FF|FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|NUCLEOTIDE METABOLISM|CHROMOSOME SEGREGATION NUCLEUS|CYTOSKELETON Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; expressed at lower level than Tub1p; TUB3 has a paralog, TUB1, that arose from the whole genome duplication nuclear migration along microtubule|nuclear migration involved in conjugation with cellular fusion|homologous chromosome segregation|mitotic sister chromatid segregation structural constituent of cytoskeleton tubulin complex|cytoplasmic microtubule|kinetochore microtubule|nuclear microtubule|spindle pole body|polar microtubule
YLR357W YLR357W RSC2 hom Verified 1.71570503575486 0.0431080213139484 no 270 0.0450081229971486 225 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION NUCLEUS RSC COMPLEX Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; involved in telomere maintenance ATP-dependent chromatin remodeling|chromosome segregation|nucleosome disassembly|plasmid maintenance|sister chromatid cohesion|double-strand break repair via nonhomologous end joining|transcription elongation from RNA polymerase II promoter|double-strand break repair via homologous recombination DNA translocase activity RSC complex
YJL142C_d YJL142C IRC9 hom Dubious 1.7154662854931 0.0431298857735131 no 271 0.030011048586489 161 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene YJL141C; null mutant displays increased levels of spontaneous Rad52p foci Unknown Unknown Unknown
YNL067W-B_p YNL067W-B YNL067W-B hom Uncharacterized 1.71286401380782 0.0433687800272957 no 272 0.0535452470165704 215 NA Putative protein of unknown function biological_process molecular_function cellular_component
YIL027C YIL027C EMC5 hom Verified 1.71217975094963 0.0434317739366679 no 273 0.0574279817004787 285 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response, and also shows K1 killer toxin resistance; homologous to worm B0334.15/EMC-5, fly CG15168, human MMGT protein folding in endoplasmic reticulum molecular_function ER membrane protein complex|endoplasmic reticulum
YHR195W YHR195W NVJ1 hom Verified 1.70978313261248 0.0436529916130037 no 274 0.0497356493500632 283 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION ENDOMEMBRANE SYSTEM|NUCLEUS Nuclear envelope protein, anchored to the nuclear inner membrane, that interacts with the vacuolar membrane protein Vac8p to promote formation of nucleus-vacuole junctions during piecemeal microautophagy of the nucleus (PMN) microautophagy|cellular protein localization protein binding nuclear envelope
YNL190W_p YNL190W YNL190W hom Uncharacterized 1.70620730948898 0.043984744151045 no 275 0.0509459160224392 258 NA Hydrophilin essential in dessication-rehydration process; cell wall protein; contains a putative GPI-attachment site cellular response to water deprivation molecular_function fungal-type cell wall
YAL026C YAL026C DRS2 hom Verified 1.70612809914273 0.0439921159684764 no 276 0.0603206219665287 324 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|RIBOSOME BIOGENESIS|ION HOMEOSTASIS|ION HOMEOSTASIS GOLGI APPARATUS Aminophospholipid translocase (flippase) that maintains membrane lipid asymmetry in post-Golgi secretory vesicles; contributes to clathrin-coated vesicle formation and endocytosis; mutations in human homolog ATP8B1 result in liver disease intracellular protein transport|post-Golgi vesicle-mediated transport|phospholipid translocation|endocytosis|ribosomal small subunit assembly phospholipid-translocating ATPase activity trans-Golgi network|integral to membrane
YER128W YER128W VFA1 hom Verified 1.70233119499398 0.0443466500856968 no 277 0.0451420885002959 228 NA FT VACUOLAR TRANSPORT Protein that interacts with Vps4p and has a role in vacuolar sorting; localizes to endosomes in a Vps4-dependent manner; overexpression causes canavanine sensitivity and confers a partial class D vacuole morphology vacuolar transport molecular_function endosome|cytoplasm
YGR223C YGR223C HSV2 hom Verified 1.69576666051272 0.0449650393274151 no 278 0.0497932177678882 249 NA FT MEMBRANE ORGANIZATION|RESPONSE TO NUTRIENT LEVELS Phosphatidylinositol 3,5-bisphosphate-binding protein, plays a role in micronucleophagy; belongs to the PROPPIN family of proteins; predicted to fold as a seven-bladed beta-propeller; displays punctate cytoplasmic localization piecemeal microautophagy of nucleus phosphatidylinositol binding endosome|fungal-type vacuole|extrinsic to membrane|cytoplasm
YER038W-A_d YER038W-A YER038W-A hom Dubious 1.69555938464233 0.0449846775056409 no 279 0.0478022671024351 195 NA Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 99% of ORF overlaps the verified gene HVG1; protein product detected in mitochondria Unknown Unknown Unknown
YMR077C YMR077C VPS20 hom Verified 1.69240801569434 0.0452841025378141 no 280 0.073651559003926 389 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|PROTEOLYSIS|VACUOLAR TRANSPORT Myristoylated subunit of ESCRTIII, the endosomal sorting complex required for transport of transmembrane proteins into the multivesicular body pathway to the lysosomal/vacuolar lumen; cytoplasmic protein recruited to endosomal membranes intralumenal vesicle formation|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|late endosome to vacuole transport protein binding ESCRT III complex|cytoplasm
YPR067W YPR067W ISA2 hom Verified 1.69076114843715 0.0454412151162068 no 281 0.0673869348326274 323 NA FT KETONE METABOLISM|COFACTOR METABOLISM MITOCHONDRION Protein required for maturation of mitochondrial [4Fe-4S] proteins; functions in a complex with Isa1p and possibly Iba57p; localizes to the mitochondrial intermembrane space, overexpression of ISA2 suppresses grx5 mutations iron-sulfur cluster assembly|biotin biosynthetic process iron ion binding mitochondrion|mitochondrial intermembrane space
YNL120C_d YNL120C YNL120C hom Dubious 1.68645124039441 0.0458544595663732 no 282 0.0372046463680473 258 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; deletion enhances replication of Brome mosaic virus in S. cerevisiae, but likely due to effects on the overlapping gene Unknown Unknown Unknown
YDR285W YDR285W ZIP1 hom Verified 1.67348633478912 0.0471157972405937 no 283 0.0501918055505886 232 NA FT CELL CYCLE NUCLEUS|CHROMOSOME Transverse filament protein of the synaptonemal complex; required for normal levels of meiotic recombination and pairing between homologous chromosome during meiosis; potential Cdc28p substrate synapsis|reciprocal meiotic recombination chromatin binding|SUMO polymer binding transverse filament
YPR147C_p YPR147C YPR147C hom Uncharacterized 1.66834147074987 0.0476239799413199 no 284 0.0550821272228968 255 NA Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS biological_process molecular_function cytoplasm
YBL065W_d YBL065W YBL065W hom Dubious 1.66526191859593 0.047930256256601 no 285 0.0552120209734029 212 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF SEF1/YBL066C; YBL065W is a non-essential gene Unknown Unknown Unknown
YML034W YML034W SRC1 hom Verified 1.66130335857009 0.0483262679186999 no 286 0.0704294666993773 351 NA FF|FT CELL CYCLE|CHROMOSOME SEGREGATION ENDOMEMBRANE SYSTEM|NUCLEUS Inner nuclear membrane protein; functions in regulation of subtelomeric genes and is linked to TREX (transcription export) factors; SRC1 produces 2 splice variant proteins with different functions; alternative splicing of SRC1 pre-mRNA is promoted by Hub1p; mutant has aneuploidy tolerance maintenance of rDNA|mitotic sister chromatid segregation molecular_function nuclear envelope
YJL170C YJL170C ASG7 hom Verified 1.65397684089793 0.0490661091632884 no 287 0.0559083663202672 247 NA FT ENDOMEMBRANE SYSTEM|PLASMA MEMBRANE Protein that regulates signaling from a G protein beta subunit Ste4p and its relocalization within the cell; specific to a-cells and induced by alpha-factor conjugation with cellular fusion molecular_function plasma membrane
YNL299W YNL299W TRF5 hom Verified 1.65232509300034 0.0492341483055809 no 288 0.059914475667632 259 NA FT CELL CYCLE|RNA PROCESSING|CELL DIVISION NUCLEUS Non-canonical poly(A) polymerase, involved in nuclear RNA degradation as a component of the TRAMP complex; catalyzes polyadenylation of hypomodified tRNAs, and snoRNA and rRNA precursors; overlapping but non-redundant functions with Pap2p nuclear polyadenylation-dependent CUT catabolic process|nuclear polyadenylation-dependent tRNA catabolic process|nuclear polyadenylation-dependent snoRNA catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|nuclear polyadenylation-dependent snRNA catabolic process|ncRNA polyadenylation|histone mRNA catabolic process|nuclear polyadenylation-dependent mRNA catabolic process|U4 snRNA 3'-end processing|polyadenylation-dependent snoRNA 3'-end processing|snoRNA polyadenylation polynucleotide adenylyltransferase activity nucleolus|TRAMP complex
YBR171W YBR171W SEC66 hom Verified 1.64915548944157 0.0495578920313781 no 289 0.127068906632442 512 NA FF|FT PROTEIN LOCALIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER posttranslational protein targeting to membrane, translocation|filamentous growth protein transporter activity integral to membrane|Sec62/Sec63 complex|endoplasmic reticulum membrane
YLR183C YLR183C TOS4 hom Verified 1.64619168614517 0.0498621502026036 no 290 0.0540311799284293 231 NA FT RESPONSE TO DNA DAMAGE NUCLEUS|MITOCHONDRION|CHROMOSOME Putative transcription factor, contains Forkhead Associated domain; found associated with chromatin; target of SBF transcription factor; expression is periodic and peaks in G1; relative distribution to the nucleus increases upon DNA replication stress; TOS4 has a paralog, PLM2, that arose from the whole genome duplication response to DNA damage stimulus chromatin binding nuclear chromatin|Rpd3L-Expanded complex|mitochondrion|nucleus|cytoplasm
YPL222W_p YPL222W FMP40 hom Uncharacterized 1.6455200675258 0.0499313038888027 no 291 0.0497683125085224 231 NA FT MITOCHONDRION Putative protein of unknown function; proposed to be involved in responding to environmental stresses; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process molecular_function mitochondrion
YMR151W_d YMR151W YIM2 hom Dubious 1.64044610038741 0.0504562233514484 no 292 0.0467704516270778 192 NA Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1 Unknown Unknown Unknown
YGL087C YGL087C MMS2 hom Verified 1.63892873841639 0.0506140508685424 no 293 0.0446788741532345 218 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RESPONSE TO DNA DAMAGE NUCLEUS Ubiquitin-conjugating enzyme variant; involved in error-free postreplication repair; forms a heteromeric complex with Ubc13p, an active ubiquitin-conjugating enzyme; cooperates with chromatin-associated RING finger proteins, Rad18p and Rad5p; protein abundance increases in response to DNA replication stress postreplication repair|response to DNA damage stimulus|protein polyubiquitination|free ubiquitin chain polymerization ubiquitin-protein ligase activity ubiquitin conjugating enzyme complex|nucleus|cytoplasm
YDR222W_p YDR222W YDR222W hom Uncharacterized 1.63722171154102 0.050792076033543 no 294 0.0705209780507517 280 NA FT RESPONSE TO OXIDATIVE STRESS Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern biological_process molecular_function cytoplasm
YHL024W YHL024W RIM4 hom Verified 1.63716559918665 0.050797936422306 no 295 0.0655022602194117 241 NA FT CELL CYCLE Putative RNA-binding protein required for the expression of early and middle sporulation genes meiosis|reciprocal meiotic recombination|sporulation resulting in formation of a cellular spore|premeiotic DNA replication RNA binding cytoplasm
YFR043C YFR043C IRC6 hom Verified 1.63631015521168 0.0508873458991744 no 296 0.0533049398808529 270 NA Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci biological_process molecular_function cellular_component
YEL065W YEL065W SIT1 hom Verified 1.6312847364194 0.0514151262777922 no 297 0.0332677381320054 186 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS Ferrioxamine B transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; transcription is induced during iron deprivation and diauxic shift; potentially phosphorylated by Cdc28p cellular iron ion homeostasis|siderophore transport|transmembrane transport siderophore uptake transmembrane transporter activity endosome|integral to membrane|cytoplasmic membrane-bounded vesicle
YFR053C YFR053C HXK1 hom Verified 1.63099892999165 0.0514452726438782 no 298 0.0628238635105649 270 NA FT CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Hexokinase isoenzyme 1; a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves hexokinase Hxk2p; HXK1 has a paralog, HXK2, that arose from the whole genome duplication mannose metabolic process|glucose import|glycolysis|fructose import|glucose metabolic process|fructose metabolic process hexokinase activity cytosol|mitochondrion|cytoplasm
YKL048C YKL048C ELM1 hom Verified 1.63023375052569 0.0515260516482634 no 299 0.0516847513704645 292 NA FT CELL CYCLE|CELL DIVISION|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION SITE OF POLARIZED GROWTH|CYTOSKELETON Serine/threonine protein kinase that regulates cellular morphogenesis, septin behavior, and cytokinesis; required for the regulation of other kinases, such as Kin4p; forms part of the bud neck ring positive regulation of protein autophosphorylation|protein autophosphorylation|cell morphogenesis|budding cell bud growth|protein phosphorylation|response to drug|septin checkpoint|pseudohyphal growth|glucose metabolic process|axial cellular bud site selection|response to osmotic stress|cytokinesis protein serine/threonine kinase activity|protein kinase activity cellular bud neck contractile ring
YLR253W_p YLR253W YLR253W hom Uncharacterized 1.62864091678554 0.0516945285342191 no 300 0.0513518937521641 240 NA FT MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; transcription is periodic during the metabolic cycle; YLR253W is not an essential gene biological_process molecular_function mitochondrion
YNR023W YNR023W SNF12 hom Verified 1.62788304978727 0.0517748430897906 no 301 0.153058975985181 528 NA FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS NUCLEUS RSC COMPLEX 73 kDa subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; homolog of Rsc6p subunit of the RSC chromatin remodeling complex; relocates to the cytosol under hypoxic conditions; deletion mutants are temperature-sensitive positive regulation of transcription from RNA polymerase II promoter in response to amino acid starvation|positive regulation of transcription from RNA polymerase II promoter molecular_function SWI/SNF complex
YOL121C YOL121C RPS19A hom Verified 1.62559145207184 0.0520182974106302 no 302 0.0520913772120302 250 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION RIBOSOME Protein component of the small (40S) ribosomal subunit; required for assembly and maturation of pre-40 S particles; homologous to mammalian ribosomal protein S19, no bacterial homolog; mutations in human RPS19 are associated with Diamond Blackfan anemia; RPS19A has a paralog, RPS19B, that arose from the whole genome duplication cytoplasmic translation|ribosomal small subunit biogenesis|rRNA export from nucleus structural constituent of ribosome cytosolic small ribosomal subunit
YMR008C YMR008C PLB1 hom Verified 1.62477706634165 0.0521050346835085 no 303 0.0477806112941989 167 NA FT LIPID METABOLISM PLASMA MEMBRANE Phospholipase B (lysophospholipase) involved in lipid metabolism, required for deacylation of phosphatidylcholine and phosphatidylethanolamine but not phosphatidylinositol glycerophospholipid metabolic process lysophospholipase activity periplasmic space|plasma membrane
YHR028C YHR028C DAP2 hom Verified 1.62303316373584 0.0522911578277634 no 304 0.0693725158577751 248 NA FT PROTEOLYSIS Dipeptidyl aminopeptidase, synthesized as a glycosylated precursor; localizes to the vacuolar membrane; similar to Ste13p protein processing dipeptidyl-peptidase activity fungal-type vacuole membrane
YGL241W YGL241W KAP114 hom Verified 1.62101579055959 0.0525071261147655 no 305 0.0516659609502396 212 NA FT PROTEIN LOCALIZATION|RNA LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS Karyopherin, responsible for nuclear import of specific proteins; cargoes include Spt15p, Sua7p, histones H2A and H2B, and Nap1p; amino terminus shows similarity to those of other importins, particularly Cse1p; localization is primarily nuclear; function is regulated by sumoylation; protein abundance increases in response to DNA replication stress protein import into nucleus|transcription factor import into nucleus protein transporter activity integral to membrane|nucleus|cytoplasm
YEL057C_p YEL057C YEL057C hom Uncharacterized 1.62044356132694 0.0525685143872617 no 306 0.0341655708666678 163 NA Protein of unknown function involved in telomere maintenance; target of UME6 regulation biological_process molecular_function cellular_component
YDL039C YDL039C PRM7 hom Verified 1.61921497726662 0.0527005082930005 no 307 0.0477864270785776 179 NA Pheromone-regulated protein, predicted to have one transmembrane segment; promoter contains Gcn4p binding elements conjugation with cellular fusion molecular_function integral to membrane
YPL258C YPL258C THI21 hom Verified 1.61802092037366 0.0528290446081756 no 308 0.0465045452684269 252 NA Hydroxymethylpyrimidine (HMP) and HMP-phosphate kinase; involved in thiamine biosynthesis; member of a gene family with THI20 and THI22; functionally redundant with Thi20p thiamine biosynthetic process phosphomethylpyrimidine kinase activity|hydroxymethylpyrimidine kinase activity cellular_component
YDL101C YDL101C DUN1 hom Verified 1.61572979862724 0.0530763726791778 no 309 0.0638694591149762 334 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION NUCLEUS Cell-cycle checkpoint serine-threonine kinase required for DNA damage-induced transcription of certain target genes, phosphorylation of Rad55p and Sml1p, and transient G2/M arrest after DNA damage; also regulates postreplicative DNA repair protein phosphorylation|replication fork protection|cell cycle checkpoint|DNA damage checkpoint protein kinase activity nucleus
YLR237W YLR237W THI7 hom Verified 1.61409494416045 0.0532534169343343 no 310 0.0721744917316099 229 NA FT PLASMA MEMBRANE Plasma membrane transporter responsible for the uptake of thiamine, member of the major facilitator superfamily of transporters; mutation of human ortholog causes thiamine-responsive megaloblastic anemia thiamine transport thiamine transmembrane transporter activity integral to membrane|plasma membrane
YKR050W YKR050W TRK2 hom Verified 1.61028241310639 0.0536681084191825 no 311 0.0616365016135211 201 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE Component of the Trk1p-Trk2p potassium transport system; TRK2 has a paralog, TRK1, that arose from the whole genome duplication cellular potassium ion homeostasis potassium ion transmembrane transporter activity integral to membrane|plasma membrane
YOL118C_d YOL118C YOL118C hom Dubious 1.60977941685167 0.0537230101258108 no 312 0.0626053100062737 244 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YNL214W YNL214W PEX17 hom Verified 1.60527153926797 0.0542170298511528 no 313 0.0641081130264963 266 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|PEROXISOME ORGANIZATION Peroxisomal membrane peroxin and subunit of the docking complex that facilitates the import of peroxisomal matrix proteins; required for peroxisome biogenesis protein import into peroxisome matrix, docking protein binding peroxisomal membrane
YDR495C YDR495C VPS3 hom Verified 1.60271424652088 0.054498878368019 no 314 0.0835188280258263 380 NA FF|FT PROTEIN LOCALIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS|VACUOLAR TRANSPORT Component of CORVET tethering complex; cytoplasmic protein required for the sorting and processing of soluble vacuolar proteins, acidification of the vacuolar lumen, and assembly of the vacuolar H+-ATPase vacuole inheritance|vacuolar acidification|protein targeting to vacuole molecular_function CORVET complex|cytoplasm
YHR138C YHR138C YHR138C hom Verified 1.60193099534623 0.0545854347525287 no 315 0.0519078386242288 214 NA FT MEMBRANE ORGANIZATION Protein of unknown function; similar to Pbi2p; double null mutant lacking Pbi2p and Yhr138cp exhibits highly fragmented vacuoles; protein abundance increases in response to DNA replication stress vacuole fusion, non-autophagic endopeptidase inhibitor activity cellular_component
YMR027W_p YMR027W YMR027W hom Uncharacterized 1.59524383621249 0.0553288597783854 no 316 0.0675889078371189 297 NA FT NUCLEUS Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; YMR027W is not an essential gene biological_process molecular_function nucleus|cytoplasm
YHL002W YHL002W HSE1 hom Verified 1.59295380714508 0.0555852770453338 no 317 0.0650773577645758 214 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT Subunit of the endosomal Vps27p-Hse1p complex required for sorting of ubiquitinated membrane proteins into intralumenal vesicles prior to vacuolar degradation, as well as for recycling of Golgi proteins and formation of lumenal membranes late endosome to vacuole transport|protein targeting to vacuole ubiquitin binding endosome|ESCRT-0 complex
YNR075W YNR075W COS10 hom Verified 1.59150353487497 0.0557481502676882 no 318 0.0446948751084261 245 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins endocytosis molecular_function nuclear envelope|integral to membrane|endoplasmic reticulum|cytoplasm
YBR037C YBR037C SCO1 hom Verified 1.58823021883836 0.0561171450981252 no 319 0.0653226167261429 297 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION Copper-binding protein of mitochondrial inner membrane; required for cytochrome c oxidase activity and respiration; may function to deliver copper to cytochrome c oxidase; similar to thioredoxins; SCO1 has a paralog, SCO2, that arose from the whole genome duplication copper ion transport|response to redox state|protein complex assembly copper ion binding|thioredoxin peroxidase activity mitochondrion|mitochondrial inner membrane
YGL104C YGL104C VPS73 hom Verified 1.58175021928476 0.0568533016744822 no 320 0.0681479438457598 270 NA FT PROTEIN LOCALIZATION|VACUOLAR TRANSPORT MITOCHONDRION Mitochondrial protein; mutation affects vacuolar protein sorting; putative transporter; member of the sugar porter family transport|transmembrane transport|protein targeting to vacuole substrate-specific transmembrane transporter activity mitochondrion|integral to membrane
YNR019W YNR019W ARE2 hom Verified 1.57520961946853 0.0576040337662979 no 321 0.0582818510398 226 NA FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Acyl-CoA:sterol acyltransferase; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the presence of oxygen; ARE2 has a paralog, ARE1, that arose from the whole genome duplication ergosterol metabolic process ergosterol O-acyltransferase activity integral to membrane|endoplasmic reticulum
YLR374C_d YLR374C YLR374C hom Dubious 1.57378685032265 0.0577683675457436 no 322 0.099435483339306 389 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF STP3/YLR375W Unknown Unknown Unknown
YJL189W YJL189W RPL39 hom Verified 1.56959931026919 0.0582541795433066 no 323 0.0633871933819007 258 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L39; required for ribosome biogenesis; loss of both Rpl31p and Rpl39p confers lethality; also exhibits genetic interactions with SIS1 and PAB1; homologous to mammalian ribosomal protein L39, no bacterial homolog cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YOR133W YOR133W EFT1 hom Verified 1.56483670814751 0.0588106010768788 no 324 0.0636018341200068 311 NA FT TRANSLATION|NUCLEOTIDE METABOLISM RIBOSOME Elongation factor 2 (EF-2), also encoded by EFT2; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin; EFT1 has a paralog, EFT2, that arose from the whole genome duplication translational elongation translation elongation factor activity ribosome
YLR095C YLR095C IOC2 hom Verified 1.56231160478728 0.0591072997499096 no 325 0.0569133065502971 263 NA FT CHROMATIN ORGANIZATION NUCLEUS Member of a complex (Isw1b) with Isw1p and Ioc4p that exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing, contains a PHD finger motif chromatin remodeling protein binding|nucleosome binding|ATPase activity|DNA binding ISW1 complex
YGL167C YGL167C PMR1 hom Verified 1.5605214664541 0.0593183505866568 no 326 0.0989679737868146 385 NA FT VESICLE-MEDIATED TRANSPORT|ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS ENDOMEMBRANE SYSTEM|GOLGI APPARATUS High affinity Ca2+/Mn2+ P-type ATPase required for Ca2+ and Mn2+ transport into Golgi; involved in Ca2+ dependent protein sorting and processing; mutations in human homolog ATP2C1 cause acantholytic skin condition Hailey-Hailey disease manganese ion transport|calcium ion transport|exocytosis manganese-transporting ATPase activity|calcium-transporting ATPase activity|calcium ion binding integral to membrane|Golgi membrane
YDR300C YDR300C PRO1 hom Verified 1.55920802181658 0.0594735764158676 no 327 0.0624713869867732 243 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Gamma-glutamyl kinase; catalyzes the first step in proline biosynthesis; PRO1 has a paralog, YHR033W, that arose from the whole genome duplication proline biosynthetic process glutamate 5-kinase activity cytoplasm
YDR198C YDR198C RKM2 hom Verified 1.55903290341198 0.0594942963347612 no 328 0.0707673569686987 236 NA Ribosomal protein lysine methyltransferase, responsible for trimethylation of the lysine residue at position 3 of Rpl12Ap and Rpl12Bp peptidyl-lysine trimethylation|peptidyl-lysine monomethylation protein-lysine N-methyltransferase activity cellular_component
YBL029W_p YBL029W YBL029W hom Uncharacterized 1.55862168837143 0.0595429733279012 no 329 0.069184968877298 260 NA FT NUCLEUS Non-essential protein of unknown function biological_process molecular_function nucleus|cytoplasm
YGR281W YGR281W YOR1 hom Verified 1.55774325352872 0.0596470613536317 no 330 0.0731400949519665 314 NA FT NUCLEOTIDE METABOLISM PLASMA MEMBRANE Plasma membrane ATP-binding cassette (ABC) transporter, multidrug transporter mediates export of many different organic anions including oligomycin; similar to human cystic fibrosis transmembrane receptor (CFTR) transport|response to drug xenobiotic-transporting ATPase activity integral to membrane|plasma membrane
YMR224C YMR224C MRE11 hom Verified 1.55493367314014 0.059980933342151 no 331 0.0661317083570878 310 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE NUCLEUS|MITOCHONDRION Subunit of the MRX complex with Rad50p and Xrs2p; complex functions in repair of DNA double-strand breaks and in telomere stability; exhibits nuclease activity that appears to be required for MRX function; widely conserved; forms nuclear foci upon DNA replication stress DNA repair|meiotic DNA double-strand break formation|double-strand break repair via nonhomologous end joining|base-excision repair|ascospore formation|meiotic DNA double-strand break processing|double-strand break repair via break-induced replication|regulation of transcription during meiosis 3'-5' exonuclease activity|protein complex scaffold|double-stranded telomeric DNA binding|adenylate kinase activity|telomeric DNA binding|single-stranded telomeric DNA binding|endodeoxyribonuclease activity|G-quadruplex DNA binding|endonuclease activity mitochondrion|nucleus|Mre11 complex
YMR241W YMR241W YHM2 hom Verified 1.5542425874915 0.0600632812567308 no 332 0.0635023739178017 278 NA FT ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS MITOCHONDRION Carrier protein that exports citrate from and imports oxoglutarate into the mitochondrion, causing net export of NADPH reducing equivalents; also associates with mt nucleoids and has a role in replication and segregation of the mt genome tricarboxylic acid transport|mitochondrial citrate transport|alpha-ketoglutarate transport|mitochondrial genome maintenance tricarboxylate secondary active transmembrane transporter activity|DNA binding mitochondrial nucleoid|mitochondrion|integral to membrane|mitochondrial inner membrane
YKL064W YKL064W MNR2 hom Verified 1.55306796010737 0.0602034497818559 no 333 0.0530621837056732 236 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS Vacuolar membrane protein required for magnesium homeostasis; putative magnesium transporter; has similarity to Alr1p and Alr2p, which mediate influx of Mg2+ and other divalent cations cellular magnesium ion homeostasis magnesium ion transmembrane transporter activity fungal-type vacuole membrane|integral to membrane
YFR019W YFR019W FAB1 hom Verified 1.54846542230062 0.060755140264401 no 334 0.0708309063877605 312 NA FT LIPID METABOLISM MITOCHONDRION 1-phosphatidylinositol-3-phosphate 5-kinase; vacuolar membrane kinase that generates phosphatidylinositol (3,5)P2, which is involved in vacuolar sorting and homeostasis phosphatidylinositol phosphorylation 1-phosphatidylinositol-3-phosphate 5-kinase activity|phosphatidylinositol-3-phosphate binding endosome membrane|mitochondrion|fungal-type vacuole membrane|PAS complex
YBR076W YBR076W ECM8 hom Verified 1.54729183155106 0.0608964452778223 no 335 0.0650996206348967 226 NA FT CELL WALL ORG/BIOGENESIS Non-essential protein of unknown function fungal-type cell wall organization molecular_function cellular_component
YOL033W YOL033W MSE1 hom Verified 1.54517141908457 0.0611524028037049 no 336 0.0878914986069782 340 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial glutamyl-tRNA synthetase, predicted to be palmitoylated mitochondrial glutamyl-tRNA aminoacylation|glutamyl-tRNA aminoacylation|mitochondrial translation glutamate-tRNA(Gln) ligase activity|glutamate-tRNA ligase activity mitochondrion
YPR146C_d YPR146C YPR146C hom Dubious 1.54116869947311 0.061637866633963 no 337 0.0519323651623415 265 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YHL042W_p YHL042W YHL042W hom Uncharacterized 1.54073936975044 0.0616901154388177 no 338 0.0542739127022606 225 NA Putative protein of unknown function; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins biological_process molecular_function cellular_component
YHR008C YHR008C SOD2 hom Verified 1.53820385578548 0.0619993892650443 no 339 0.125498530351938 438 NA FF|FT OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS MITOCHONDRION Mitochondrial manganese superoxide dismutase, protects cells against oxygen toxicity; phosphorylated reactive oxygen species metabolic process|age-dependent response to oxidative stress involved in chronological cell aging|replicative cell aging|age-dependent response to reactive oxygen species involved in chronological cell aging superoxide dismutase activity mitochondrion|mitochondrial matrix
YLR264W YLR264W RPS28B hom Verified 1.5369618507969 0.0621513258634635 no 340 0.0645758060502001 270 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S28, no bacterial homolog; RPS28B has a paralog, RPS28A, that arose from the whole genome duplication cytoplasmic translation|rRNA export from nucleus structural constituent of ribosome cytosolic small ribosomal subunit
YLR372W YLR372W SUR4 hom Verified 1.53571391309079 0.0623042806162187 no 341 0.214317740282292 749 NA FF|FT VESICLE-MEDIATED TRANSPORT|KETONE METABOLISM|LIPID METABOLISM ENDOPLASMIC RETICULUM Elongase, involved in fatty acid and sphingolipid biosynthesis; synthesizes very long chain 20-26-carbon fatty acids from C18-CoA primers; involved in regulation of sphingolipid biosynthesis post-Golgi vesicle-mediated transport|fatty acid elongation|fatty acid biosynthetic process|sphingolipid biosynthetic process fatty acid elongase activity integral to membrane|endoplasmic reticulum
YLR250W YLR250W SSP120 hom Verified 1.53324773986316 0.062607412822385 no 342 0.06042413958311 238 NA Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern biological_process molecular_function cytoplasm
YBR028C YBR028C YPK3 hom Verified 1.53226176262771 0.0627289264264685 no 343 0.0836274029222611 303 NA FT PROTEIN PHOSPHORYLATION An AGC kinase phosphorylated by cAMP-dependent protein kinase (PKA) in a TORC1-dependent manner biological_process protein kinase activity cytoplasm
YNL101W YNL101W AVT4 hom Verified 1.53073544262811 0.0629173952311205 no 344 0.0554785785944118 256 NA FT VACUOLAR TRANSPORT Vacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters amino acid export from vacuole transporter activity|L-glutamine transmembrane transporter activity|L-isoleucine transmembrane transporter activity|L-tyrosine transmembrane transporter activity fungal-type vacuole membrane|integral to membrane|fungal-type vacuole
YCL029C YCL029C BIK1 hom Verified 1.52819550360226 0.0632320024272361 no 345 0.0679987794667879 316 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION NUCLEUS|SITE OF POLARIZED GROWTH|CHROMOSOME|CYTOSKELETON KINETOCHORE Microtubule-associated protein, component of the interface between microtubules and kinetochore, involved in sister chromatid separation; essential in polyploid cells but not in haploid or diploid cells; ortholog of mammalian CLIP-170 karyogamy involved in conjugation with cellular fusion|mitotic anaphase B|negative regulation of microtubule polymerization|nuclear migration involved in conjugation with cellular fusion|mitotic spindle organization in nucleus|mitotic spindle elongation microtubule binding|protein homodimerization activity spindle microtubule|microtubule plus end|spindle pole body|cell cortex|condensed nuclear chromosome kinetochore|mating projection tip|kinetochore|spindle
YPL023C YPL023C MET12 hom Verified 1.52310042436709 0.0638667913540332 no 346 0.0685230497387929 300 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS Protein with methylenetetrahydrofolate reductase (MTHFR) activity in vitro; null mutant has no phenotype and is prototrophic for methionine; MET13 encodes major isozyme of MTHFR biological_process methylenetetrahydrofolate reductase (NADPH) activity cellular_component
YJL079C YJL079C PRY1 hom Verified 1.52069230652763 0.0641685351359781 no 347 0.0418941627658581 234 NA FT ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM Sterol binding protein involved in the export of acetylated sterols; secreted glycoprotein and member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis related 1 proteins); sterol export function is redundant with that of PRY2; may be involved in detoxification of hydrophobic compounds; PRY1 has a paralog, PRY2, that arose from the whole genome duplication biological_process molecular_function nuclear envelope|extracellular region|endoplasmic reticulum|fungal-type vacuole
YLR445W YLR445W GMC2 hom Verified 1.51763790939031 0.0645528523071694 no 348 0.061656286674098 303 NA FT CELL CYCLE Protein involved in meiotic progression; mutants are delayed in meiotic nuclear division and are defective in synaptonemal complex assembly; transcription is regulated by Ume6p and induced in response to alpha factor meiosis|synaptonemal complex organization molecular_function cellular_component
YIL054W_p YIL054W YIL054W hom Uncharacterized 1.51637160356013 0.064712707599603 no 349 0.0667914496501501 307 NA Protein of unknown function; expressed at both mRNA and protein levels biological_process molecular_function cellular_component
YJL013C YJL013C MAD3 hom Verified 1.51270963683717 0.0651767153161976 no 350 0.0506959071229851 229 NA FT CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION NUCLEUS Subunit of the spindle-assembly checkpoint complex, which delays anaphase onset in cells with defects in mitotic spindle assembly; pseudosubstrate inhibitor of APC(Cdc20), the anaphase promoting complex involved in securin (Pds1p) turnover distributive segregation|mitotic cell cycle spindle assembly checkpoint|mitotic cell cycle G2/M transition decatenation checkpoint molecular_function mitotic checkpoint complex
YOR161C YOR161C PNS1 hom Verified 1.51237415019987 0.0652193535820455 no 351 0.0692761866595551 292 NA FT PLASMA MEMBRANE Protein of unknown function; has similarity to Torpedo californica tCTL1p, which is postulated to be a choline transporter, neither null mutation nor overexpression affects choline transport biological_process choline transmembrane transporter activity|molecular_function integral to membrane|plasma membrane|integral to plasma membrane
YJL110C YJL110C GZF3 hom Verified 1.50848967215275 0.0657146239920527 no 352 0.0761247629789545 300 NA FT PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS NUCLEUS GATA zinc finger protein; negatively regulates nitrogen catabolic gene expression by competing with Gat1p for GATA site binding; function requires a repressive carbon source; dimerizes with Dal80p and binds to Tor1p; GZF3 has a paralog, DAL80, that arose from the whole genome duplication maintenance of protein location in nucleus|nitrogen catabolite repression of transcription|negative regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding RNA polymerase II transcription factor activity|sequence-specific DNA binding nucleus
YPR166C YPR166C MRP2 hom Verified 1.50618272615892 0.0660101362708029 no 353 0.0893089322346395 329 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the small subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial small ribosomal subunit
YOR049C YOR049C RSB1 hom Verified 1.50526473825627 0.0661280135109271 no 354 0.0632558592090275 255 NA FT MEMBRANE ORGANIZATION ENDOPLASMIC RETICULUM|PLASMA MEMBRANE Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane phospholipid translocation|fatty acid transport phospholipid-translocating ATPase activity integral to membrane|endoplasmic reticulum|plasma membrane
YJR126C YJR126C VPS70 hom Verified 1.50512357545435 0.066146154438742 no 355 0.0563406478291817 228 NA FT PROTEIN LOCALIZATION|PROTEOLYSIS|VACUOLAR TRANSPORT Protein of unknown function involved in vacuolar protein sorting protein targeting to vacuole molecular_function cellular_component
YGR068C YGR068C ART5 hom Verified 1.50323857438805 0.0663887668043046 no 356 0.0679025695456372 294 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION Protein proposed to regulate the endocytosis of plasma membrane proteins by recruiting the ubiquitin ligase Rsp5p to its target in the plasma membrane ubiquitin-dependent endocytosis ubiquitin protein ligase binding cellular_component
YMR294W YMR294W JNM1 hom Verified 1.49973450887737 0.0668415938880749 no 357 0.0948691530218375 437 NA FF|FT CELL CYCLE|CYTOSKELETON ORGANIZATION CYTOSKELETON Component of the yeast dynactin complex, consisting of Nip100p, Jnm1p, and Arp1p; required for proper nuclear migration and spindle partitioning during mitotic anaphase B nuclear migration|establishment of mitotic spindle orientation structural constituent of cytoskeleton dynactin complex|cell cortex|spindle pole body|astral microtubule
YMR099C YMR099C YMR099C hom Verified 1.4971923102359 0.0671716128455596 no 358 0.0812620725180667 343 NA FT CARBOHYDRATE METABOLISM NUCLEUS Glucose-6-phosphate 1-epimerase (hexose-6-phosphate mutarotase), likely involved in carbohydrate metabolism; GFP-fusion protein localizes to both the nucleus and cytoplasm and is induced in response to the DNA-damaging agent MMS cellular carbohydrate metabolic process glucose-6-phosphate 1-epimerase activity nucleus|cytoplasm
YLR133W YLR133W CKI1 hom Verified 1.49361893048714 0.0676376243283889 no 359 0.104901250108067 368 NA FT LIPID METABOLISM Choline kinase; catalyzes the first step in phosphatidylcholine synthesis via the CDP-choline (Kennedy pathway); exhibits some ethanolamine kinase activity contributing to phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway; CKI1 has a paralog, EKI1, that arose from the whole genome duplication phosphatidylethanolamine biosynthetic process|phosphatidylcholine biosynthetic process ethanolamine kinase activity|choline kinase activity cytoplasm
YLR040C_p YLR040C YLR040C hom Uncharacterized 1.49340085498193 0.0676661446515464 no 360 0.0731481081339894 304 NA Protein of unknown function; localizes to the cell wall; predicted to be a GPI-attached protein; upregulated by Mcm1p-Alpha1p transcription factor; partially overlaps the dubious ORF YLR041W; mRNA identified as translated by ribosome profiling data; YLR040C is not essential biological_process molecular_function fungal-type cell wall
YDL112W YDL112W TRM3 hom Verified 1.48596137196973 0.0686446693289279 no 361 0.0777915903732059 295 NA FT RNA PROCESSING 2'-O-ribose methyltransferase, catalyzes the ribose methylation of the guanosine nucleotide at position 18 of tRNAs tRNA methylation tRNA (guanine) methyltransferase activity cytoplasm
YER123W YER123W YCK3 hom Verified 1.48227836526543 0.0691331212236122 no 362 0.0990538467168913 395 NA FT VESICLE-MEDIATED TRANSPORT|PROTEIN PHOSPHORYLATION ENDOMEMBRANE SYSTEM|NUCLEUS|PLASMA MEMBRANE Palmitoylated, vacuolar membrane-localized casein kinase I isoform; negatively regulates vacuole fusion during hypertonic stress via phosphorylation of Vps41p; shares essential functions with Hrr25p; regulates vesicle fusion in AP-3 pathway vesicle-mediated transport|protein phosphorylation protein serine/threonine kinase activity|protein kinase activity fungal-type vacuole membrane|plasma membrane|nucleus|fungal-type vacuole
YER014C-A YER014C-A BUD25 hom Verified 1.48162802749373 0.0692196485889718 no 363 0.0653732995720452 236 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CELL DIVISION Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern cellular bud site selection molecular_function cellular_component
YLR057W YLR057W MNL2 hom Verified 1.47268209810233 0.0704183879602056 no 364 0.0817865979227522 335 NA FT PROTEOLYSIS ENDOPLASMIC RETICULUM Putative mannosidase involved in ER-associated protein degradation; localizes to the endoplasmic reticulum; sequence similarity with seven-hairpin glycosidase (GH47) family members, such as Mns1p and Mnl1p, that hydrolyze 1,2-linked alpha-D-mannose residues; non-essential gene ER-associated protein catabolic process molecular_function endoplasmic reticulum
YFR049W YFR049W YMR31 hom Verified 1.47239598364164 0.0704569885594291 no 365 0.0868953100604245 350 NA FT TRANSLATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the small subunit, has similarity to human mitochondrial ribosomal protein MRP-S36 cytoplasmic translation structural constituent of ribosome mitochondrion|mitochondrial small ribosomal subunit
YJR001W YJR001W AVT1 hom Verified 1.47171095319556 0.0705494742620939 no 366 0.104008883385914 422 NA FT VACUOLAR TRANSPORT Vacuolar transporter, imports large neutral amino acids into the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters amino acid transport|vacuolar transport transporter activity|L-glutamine transmembrane transporter activity|L-isoleucine transmembrane transporter activity|L-tyrosine transmembrane transporter activity fungal-type vacuole membrane|integral to membrane|fungal-type vacuole
YEL053C YEL053C MAK10 hom Verified 1.47000522540833 0.0707801693797359 no 367 0.0645313327219635 306 NA Non-catalytic subunit of N-terminal acetyltransferase of the NatC type, required for replication of dsRNA virus; expression is glucose-repressible N-terminal protein amino acid acetylation peptide alpha-N-acetyltransferase activity NatC complex|cytoplasm
YGL159W_p YGL159W YGL159W hom Uncharacterized 1.46984824695629 0.070801429386922 no 368 0.0844113745110214 371 NA Putative protein of unknown function; deletion mutant has no detectable phenotype biological_process molecular_function cellular_component
YIL071C YIL071C PCI8 hom Verified 1.46907171781537 0.0709066689544147 no 369 0.081950747499799 338 NA FT NUCLEUS Possible shared subunit of Cop9 signalosome (CSN) and eIF3, binds eIF3b subunit Prt1p, has possible dual functions in transcriptional and translational control, contains a PCI (Proteasome-COP9 signalosome (CSN)-eIF3) domain cullin deneddylation molecular_function signalosome
YPR060C YPR060C ARO7 hom Verified 1.4688837384232 0.0709321630282446 no 370 0.11501639169717 494 NA FF|FT KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS Chorismate mutase, catalyzes the conversion of chorismate to prephenate to initiate the tyrosine/phenylalanine-specific branch of aromatic amino acid biosynthesis aromatic amino acid family biosynthetic process chorismate mutase activity nucleus|cytoplasm
YGL041C-B_p YGL041C-B YGL041C-B hom Uncharacterized 1.467637580125 0.0711013471494013 no 371 0.0564735182773232 229 NA Putative protein of unknown function; identified by fungal homology and RT-PCR biological_process molecular_function cellular_component
YIL121W YIL121W QDR2 hom Verified 1.467115094387 0.0711723743215475 no 372 0.0578227683329503 237 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; exports copper; has broad substrate specificity and can transport many mono- and divalent cations; transports a variety of drugs and is required for resistance to quinidine, barban, cisplatin, and bleomycin; contributes to potassium homeostasis; expression is regulated by copper drug transmembrane transport|potassium ion import drug transmembrane transporter activity integral to membrane|integral to plasma membrane
YGL013C YGL013C PDR1 hom Verified 1.46687889722275 0.0712045010477157 no 373 0.183834728890548 710 NA FF|FT TRANSCRIPTION FROM RNA POL II NUCLEUS RSC COMPLEX Transcription factor that regulates the pleiotropic drug response; zinc cluster protein that is a master regulator involved in recruiting other zinc cluster proteins to pleiotropic drug response elements (PDREs) to fine tune the regulation of multidrug resistance genes; PDR1 has a paralog, PDR3, that arose from the whole genome duplication Unknown|positive regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus
YBR228W YBR228W SLX1 hom Verified 1.46584424094518 0.0713453626612357 no 374 0.0821941620767143 332 NA FT RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME Subunit of a complex, with Slx4p, that hydrolyzes 5' branches from duplex DNA in response to stalled or converging replication forks; function overlaps with that of Sgs1p-Top3p DNA-dependent DNA replication 5'-flap endonuclease activity Slx1-Slx4 complex|nucleus
YIR027C YIR027C DAL1 hom Verified 1.46547815928437 0.0713952534564917 no 375 0.0836266190090595 314 NA Allantoinase, converts allantoin to allantoate in the first step of allantoin degradation; expression sensitive to nitrogen catabolite repression allantoin assimilation pathway allantoinase activity cellular_component
YFR048W YFR048W RMD8 hom Verified 1.46481504455356 0.0714856930568413 no 376 0.0728317578635847 294 NA FT CELL CYCLE Cytosolic protein required for sporulation biological_process molecular_function cytoplasm
YLR182W YLR182W SWI6 hom Verified 1.46272894144897 0.0717707818000586 no 377 0.0978856820239798 373 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE NUCLEUS Transcription cofactor; forms complexes with Swi4p and Mbp1p to regulate transcription at the G1/S transition; involved in meiotic gene expression; also binds Stb1p to regulate transcription at START; cell wall stress induces phosphorylation by Mpk1p, which regulates Swi6p localization; required for the unfolded protein response, independently of its known transcriptional coactivators positive regulation of transcription from RNA polymerase II promoter in response to heat stress|positive regulation of transcription involved in G1/S phase of mitotic cell cycle|positive regulation of reciprocal meiotic recombination|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II transcription coactivator activity SBF transcription complex|MBF transcription complex|nucleus|cytoplasm
YML016C YML016C PPZ1 hom Verified 1.46137359203631 0.0719564719027748 no 378 0.0887365001921015 308 NA FT PROTEIN LOCALIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS NUCLEUS|PLASMA MEMBRANE Serine/threonine protein phosphatase Z, isoform of Ppz2p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance cellular sodium ion homeostasis|cellular protein localization|protein dephosphorylation protein serine/threonine phosphatase activity extrinsic to plasma membrane|nucleus|cytoplasm
YMR219W YMR219W ESC1 hom Verified 1.45591716858439 0.0727077594780321 no 379 0.0830869564871313 330 NA FT GENE SILENCING NUCLEUS Protein localized to the nuclear periphery, involved in telomeric silencing; interacts with PAD4-domain of Sir4p chromatin silencing at telomere molecular_function nuclear periphery
YML112W YML112W CTK3 hom Verified 1.45345234938986 0.073049100352556 no 380 0.132582563502824 480 NA FF|FT RNA PROCESSING|RESPONSE TO DNA DAMAGE|TRANSLATION|PROTEIN PHOSPHORYLATION NUCLEUS Gamma subunit of C-terminal domain kinase I; CTDK-I phosphorylates RNA polymerase II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and also phosphorylates ribosomal protein Rps2p to increase translational fidelity; protein abundance increases in response to DNA replication stress mRNA 3'-end processing|positive regulation of translational fidelity|positive regulation of transcription from RNA polymerase I promoter|positive regulation of DNA-dependent transcription, elongation|protein phosphorylation cyclin-dependent protein kinase activity nucleoplasm|nucleolus|carboxy-terminal domain protein kinase complex
YKL006W YKL006W RPL14A hom Verified 1.45293751770003 0.0731205514849514 no 381 0.0923603980713149 380 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L14A; N-terminally acetylated; homologous to mammalian ribosomal protein L14, no bacterial homolog; RPL14A has a paralog, RPL14B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome|RNA binding cytosolic large ribosomal subunit
YML050W YML050W AIM32 hom Verified 1.4510235747247 0.0733866478880456 no 382 0.0890100311371624 333 NA Putative protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss biological_process molecular_function cellular_component
YAR014C YAR014C BUD14 hom Verified 1.44709558332935 0.0739350774329169 no 383 0.0686779008655611 387 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH Protein involved in bud-site selection; Bud14p-Glc7p complex is a cortical regulator of dynein; inhibitor of the actin assembly factor Bnr1p (formin); diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; relative distribution to the nucleus increases upon DNA replication stress regulation of cell shape during vegetative growth phase|regulation of protein localization|regulation of transcription, DNA-dependent|cytoskeleton organization|negative regulation of actin filament polymerization protein phosphatase type 1 regulator activity incipient cellular bud site|cellular bud neck|cellular bud tip
YMR105W-A_p YMR105W-A YMR105W-A hom Uncharacterized 1.44641172255067 0.074030877920917 no 384 0.0983796073934296 416 NA Putative protein of unknown function biological_process molecular_function cellular_component
YML024W YML024W RPS17A hom Verified 1.4453012394663 0.0741866449444032 no 385 0.0675019690047232 280 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Ribosomal protein 51 (rp51) of the small (40s) subunit; homologous to mammalian ribosomal protein S17, no bacterial homolog; RPS17A has a paralog, RPS17B, that arose from the whole genome duplication cytoplasmic translation|ribosomal small subunit assembly structural constituent of ribosome cytosolic small ribosomal subunit
YPL253C YPL253C VIK1 hom Verified 1.44292350036367 0.0745210111486732 no 386 0.0773438157191829 360 NA FT CELL CYCLE|CHROMOSOME SEGREGATION NUCLEUS|CYTOSKELETON Protein that forms a complex with Kar3p at the spindle pole body, possible regulator of Kar3p function in microtubule-mediated processes; required for sister chromatid cohesion; has similarity to Cik1p microtubule-based process|mitotic sister chromatid cohesion microtubule motor activity kinesin complex|spindle pole body
YIL173W YIL173W VTH1 hom Verified 1.44097412720915 0.0747959961587969 no 387 0.0497583435283639 193 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT GOLGI APPARATUS Putative membrane glycoprotein with strong similarity to Vth2p and Pep1p/Vps10p, may be involved in vacuolar protein sorting Golgi to vacuole transport signal sequence binding endosome|integral to membrane
YKR026C YKR026C GCN3 hom Verified 1.43905118060641 0.0750680112067237 no 388 0.116600366519261 544 NA FF|FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION Alpha subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a positive regulator of GCN4 expression regulation of translational initiation enzyme regulator activity|guanyl-nucleotide exchange factor activity|translation initiation factor activity eukaryotic translation initiation factor 2B complex|guanyl-nucleotide exchange factor complex
YML072C YML072C TCB3 hom Verified 1.43839107294888 0.0751615620610609 no 389 0.0830025721244388 353 NA FT ENDOPLASMIC RETICULUM|MITOCHONDRION|PLASMA MEMBRANE Cortical ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; localized to the bud via specific mRNA transport; non-tagged protein detected in a phosphorylated state in mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact biological_process lipid binding mitochondrion|cortical endoplasmic reticulum|cellular bud
YPL254W YPL254W HFI1 hom Verified 1.43370343121984 0.075828456312378 no 390 0.0903474044758904 378 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION NUCLEUS HISTONE ACETYLTRANSFERASE Adaptor protein required for structural integrity of the SAGA complex, a histone acetyltransferase-coactivator complex that is involved in global regulation of gene expression through acetylation and transcription functions histone acetylation|chromatin modification|transcription from RNA polymerase II promoter transcription coactivator activity|transcription cofactor activity SLIK (SAGA-like) complex|Ada2/Gcn5/Ada3 transcription activator complex|SAGA complex
YGL257C YGL257C MNT2 hom Verified 1.43354667983668 0.0758508343960288 no 391 0.0739347095858065 253 NA FT CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Mannosyltransferase involved in adding the 4th and 5th mannose residues of O-linked glycans protein O-linked glycosylation alpha-1,3-mannosyltransferase activity cellular_component
YKR001C YKR001C VPS1 hom Verified 1.43235418464618 0.0760212416609842 no 392 0.167203933480459 573 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CELL DIVISION|NUCLEOTIDE METABOLISM|CYTOSKELETON ORGANIZATION|VACUOLAR TRANSPORT|PEROXISOME ORGANIZATION MITOCHONDRION|CYTOSKELETON Dynamin-like GTPase required for vacuolar sorting; also involved in actin cytoskeleton organization, endocytosis, late Golgi-retention of some proteins, regulation of peroxisome biogenesis vacuolar transport|peroxisome fission|endocytosis|actin cytoskeleton organization|protein retention in Golgi apparatus|peroxisome organization|lipid tube assembly|protein targeting to vacuole GTPase activity mitochondrial outer membrane|fungal-type vacuole membrane|peroxisome|actin cortical patch
YKR084C YKR084C HBS1 hom Verified 1.42906420486522 0.0764928902705722 no 393 0.0811161683447612 368 NA FT TRANSLATION|NUCLEOTIDE METABOLISM GTPase with similarity to translation release factors; together with binding partner Dom34p, facilitates ribosomal subunit dissociation and peptidyl-tRNA release when translation is stalled; genetically implicated in mRNA no-go decay nuclear-transcribed mRNA catabolic process, no-go decay|ribosome disassembly|nonfunctional rRNA decay ribosome binding|GTPase activity cytoplasm
YHR048W_p YHR048W YHK8 hom Uncharacterized 1.4287052162122 0.0765444889714392 no 394 0.0896170833296157 339 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS Presumed antiporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; expression of gene is up-regulated in cells exhibiting reduced susceptibility to azoles drug transport molecular_function integral to membrane
YGR181W YGR181W TIM13 hom Verified 1.42710110209732 0.0767753774442056 no 395 0.0486281235240009 242 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial intermembrane space protein, forms a complex with Tim8p that delivers a subset of hydrophobic proteins to the TIM22 complex for insertion into the inner membrane protein import into mitochondrial inner membrane protein transporter activity mitochondrion|integral to membrane|mitochondrial intermembrane space protein transporter complex|mitochondrial intermembrane space
YLR387C YLR387C REH1 hom Verified 1.42401359363735 0.0772212685308107 no 396 0.100051328295107 342 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS RIBOSOME Cytoplasmic 60S subunit biogenesis factor, associates with pre-60S particles; similar to Rei1p and shares partially redundant function in cytoplasmic 60S subunit maturation; contains dispersed C2H2 zinc finger domains ribosomal large subunit biogenesis|budding cell bud growth molecular_function cytosolic large ribosomal subunit|preribosome, large subunit precursor|cytoplasm
YMR172W YMR172W HOT1 hom Verified 1.423251800092 0.0773315870758606 no 397 0.0583052754125442 266 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Transcription factor required for the transient induction of glycerol biosynthetic genes GPD1 and GPP2 in response to high osmolarity; targets Hog1p to osmostress responsive promoters; has similarity to Msn1p and Gcr1p cellular hyperosmotic salinity response|RNA polymerase II transcriptional preinitiation complex assembly|positive regulation of transcription from RNA polymerase II promoter in response to osmotic stress|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly|sequence-specific DNA binding RNA polymerase II transcription factor activity nucleus
YER068W YER068W MOT2 hom Verified 1.42297853219283 0.0773711893170188 no 398 0.0886069861242174 317 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Ubiquitin-protein ligase subunit of the CCR4-NOT complex; with Ubc4p, ubiquitinates nascent polypeptide-associated complex subunits and histone demethyase Jhd2p; CCR4-NOT has roles in transcription regulation, mRNA degradation, and post-transcriptional modifications deadenylation-independent decapping of nuclear-transcribed mRNA|positive regulation of transcription elongation from RNA polymerase II promoter|protein polyubiquitination|protein ubiquitination ubiquitin-protein ligase activity|sequence-specific DNA binding CCR4-NOT core complex|cytoplasm
YNL041C YNL041C COG6 hom Verified 1.42271652501409 0.0774091741074601 no 399 0.233532301725229 818 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments intra-Golgi vesicle-mediated transport|CVT pathway molecular_function Golgi transport complex
YHL028W YHL028W WSC4 hom Verified 1.42153750173131 0.0775802796464475 no 400 0.0632805716757124 288 NA FT PROTEIN LOCALIZATION|CELL WALL ORG/BIOGENESIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM ER membrane protein involved in the translocation of soluble secretory proteins and insertion of membrane proteins into the ER membrane; may also have a role in the stress response but has only partial functional overlap with WSC1-3 response to heat|SRP-dependent cotranslational protein targeting to membrane, translocation|protein targeting to ER|response to stress transmembrane signaling receptor activity endoplasmic reticulum membrane
YDL168W YDL168W SFA1 hom Verified 1.41802621029371 0.0780915563352418 no 401 0.109090339419448 347 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS MITOCHONDRION Bifunctional alcohol dehydrogenase and formaldehyde dehydrogenase; formaldehyde dehydrogenase activity is glutathione-dependent; functions in formaldehyde detoxification and formation of long chain and complex alcohols, regulated by Hog1p-Sko1p; protein abundance increases in response to DNA replication stress furaldehyde metabolic process|formaldehyde catabolic process|amino acid catabolic process to alcohol via Ehrlich pathway S-(hydroxymethyl)glutathione dehydrogenase activity|hydroxymethylfurfural reductase (NADH) activity|alcohol dehydrogenase (NAD) activity mitochondrion|cytoplasm
YIL013C YIL013C PDR11 hom Verified 1.41632175406628 0.0783406607018442 no 402 0.0813235511428361 368 NA FT NUCLEOTIDE METABOLISM ATP-binding cassette (ABC) transporter, multidrug transporter involved in multiple drug resistance; mediates sterol uptake when sterol biosynthesis is compromised; regulated by Pdr1p; required for anaerobic growth sterol transport ATPase activity, coupled to transmembrane movement of substances integral to membrane|membrane
YGL041C_d YGL041C YGL041C hom Dubious 1.41533457574533 0.0784852109960946 no 403 0.0903979282545698 357 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YMR158C-A_p YMR158C-A YMR158C-A hom Uncharacterized 1.41359861150052 0.0787398946033475 no 404 0.0656659811019292 279 NA Putative protein of unknown function, may contain a lipid attachment site; YMR158C-A is not an essential gene biological_process molecular_function cellular_component
YKR064W YKR064W OAF3 hom Verified 1.40473268541012 0.0800503912473013 no 405 0.0914914582834419 318 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS|MITOCHONDRION Putative transcriptional repressor with Zn(2)-Cys(6) finger; negatively regulates transcription in response to oleate levels, based on mutant phenotype and localization to oleate-responsive promoters; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; forms nuclear foci upon DNA replication stress negative regulation of transcription from RNA polymerase II promoter|cellular response to oleic acid RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity mitochondrion|nucleus|cytoplasm
YHR080C YHR080C YHR080C hom Verified 1.40259214366848 0.0803692479491365 no 406 0.0863899486925769 378 NA FT MITOCHONDRION Protein of unknown function; may interact with ribosomes, based on co-purification experiments; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YHR080C has a paralog, YSP2, that arose from the whole genome duplication biological_process molecular_function mitochondrion|ribosome
YGR104C YGR104C SRB5 hom Verified 1.39977126936598 0.0807909119755804 no 407 0.0891614721912493 377 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS RNA POL II, HOLOENZYME Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; required for proper termination of transcription for some genes; involved in telomere maintenance transcriptional open complex formation at RNA polymerase II promoter|RNA polymerase II transcriptional preinitiation complex assembly|positive regulation of transcription from RNA polymerase II promoter core RNA polymerase II binding transcription factor activity|RNA polymerase II transcription factor recruiting transcription factor activity|TBP-class protein binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly core mediator complex
YLR125W_p YLR125W YLR125W hom Uncharacterized 1.39971406123086 0.0807994806908664 no 408 0.0793507308394418 348 NA Putative protein of unknown function; mutant has decreased Ty3 transposition; YLR125W is not an essential gene biological_process molecular_function cellular_component
YGR288W YGR288W MAL13 hom Verified 1.39893955757676 0.0809155544807831 no 409 0.0775102887776943 360 NA FT TRANSCRIPTION FROM RNA POL II|CARBOHYDRATE METABOLISM NUCLEUS MAL-activator protein, part of complex locus MAL1; nonfunctional in genomic reference strain S288C cellular carbohydrate metabolic process|regulation of transcription, DNA-dependent sequence-specific DNA binding transcription factor activity nucleus
YFR012W-A_p YFR012W-A YFR012W-A hom Uncharacterized 1.39795393137685 0.081063450881284 no 410 0.0518813813657981 250 NA Putative protein of unknown function; identified by homology biological_process molecular_function cellular_component
YGR041W YGR041W BUD9 hom Verified 1.39653851868484 0.0812761948594464 no 411 0.0551371011185616 210 NA FT CELL CYCLE|CELL DIVISION SITE OF POLARIZED GROWTH|PLASMA MEMBRANE Protein involved in bud-site selection; mutant has increased aneuploidy tolerance; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the distal pole cellular bud site selection molecular_function plasma membrane|cellular bud neck
YIL163C_p YIL163C YIL163C hom Uncharacterized 1.39500446647507 0.0815072463402745 no 412 0.0689216584328238 311 NA Protein of unknown function; mRNA identified as translated by ribosome profiling data biological_process molecular_function cellular_component
YKL075C_p YKL075C YKL075C hom Uncharacterized 1.3936079872334 0.0817180076241817 no 413 0.0903139522914562 306 NA Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; proposed to be involved in resistance to streptozotocin and camptothecin response to drug molecular_function cytoplasm
YGL251C YGL251C HFM1 hom Verified 1.39112333150845 0.082094015478088 no 414 0.10278715131514 401 NA FT CELL CYCLE NUCLEUS Meiosis specific DNA helicase involved in the conversion of double-stranded breaks to later recombination intermediates and in crossover control; catalyzes the unwinding of Holliday junctions; has ssDNA and dsDNA stimulated ATPase activity meiosis|synapsis|DNA unwinding involved in replication|reciprocal meiotic recombination DNA helicase activity nucleus
YBR146W YBR146W MRPS9 hom Verified 1.38718023494183 0.0826934054082742 no 415 0.0899970037436557 347 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the small subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial small ribosomal subunit
YFL013W-A_d YFL013W-A YFL013W-A hom Dubious 1.38509776171874 0.0830112881213169 no 416 0.0973702932631804 388 NA Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps IES1/YFL013C; identified by gene-trapping, microarray expression analysis, and genome-wide homology searching Unknown Unknown Unknown
YLR108C YLR108C YLR108C hom Verified 1.38377140000666 0.083214231475682 no 417 0.0945329215578864 296 NA FT NUCLEUS Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YLR108C is not an esssential gene; protein abundance increases in response to DNA replication stress; YLR108C has a paralog, YDR132C, that arose from the whole genome duplication biological_process molecular_function nucleus
YMR038C YMR038C CCS1 hom Verified 1.38119795373327 0.0836090518920335 no 418 0.154148118780888 578 NA FF|FT ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|RESPONSE TO OXIDATIVE STRESS NUCLEUS|MITOCHONDRION Copper chaperone for superoxide dismutase Sod1p; involved in oxidative stress protection; Met-X-Cys-X2-Cys motif within the N-terminal portion is involved in insertion of copper into Sod1p under conditions of copper deprivation; protein abundance increases in response to DNA replication stress intracellular copper ion transport superoxide dismutase copper chaperone activity cytosol|mitochondrial inner membrane|nucleus
YJR122W YJR122W IBA57 hom Verified 1.37311625463472 0.0848581043082297 no 419 0.12948997112067 516 NA FF|FT COFACTOR METABOLISM MITOCHONDRION Mitochondrial matrix protein involved in the incorporation of iron-sulfur clusters into mitochondrial aconitase-type proteins; activates the radical-SAM family members Bio2p and Lip5p; interacts with Ccr4p in the two-hybrid system iron-sulfur cluster assembly molecular_function mitochondrion|mitochondrial matrix
YGL031C YGL031C RPL24A hom Verified 1.37310533809528 0.0848598009041711 no 420 0.0929089905990279 400 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L24A; not essential for translation but may be required for normal translation rate; homologous to mammalian ribosomal protein L24, no bacterial homolog; RPL24A has a paralog, RPL24B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome|RNA binding cytosolic large ribosomal subunit
YBL082C YBL082C ALG3 hom Verified 1.37039815238692 0.0852813242658605 no 421 0.0687692724710883 283 NA FT LIPID METABOLISM|CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Dolichol-P-Man dependent alpha(1-3) mannosyltransferase, involved in the synthesis of dolichol-linked oligosaccharide donor for N-linked glycosylation of proteins oligosaccharide-lipid intermediate biosynthetic process|protein glycosylation alpha-1,3-mannosyltransferase activity integral to membrane|endoplasmic reticulum
YAL024C YAL024C LTE1 hom Verified 1.37001095170204 0.0853417414964702 no 422 0.139585595656663 520 NA FF|FT VESICLE-MEDIATED TRANSPORT|CELL CYCLE|SIGNALING|CELL DIVISION Protein similar to GDP/GTP exchange factors but without detectable GEF activity; required for asymmetric localization of Bfa1p at daughter-directed spindle pole bodies and for mitotic exit at low temperatures regulation of exit from mitosis|mitotic cell cycle spindle orientation checkpoint|vesicle-mediated transport guanyl-nucleotide exchange factor activity cellular bud
YGR157W YGR157W CHO2 hom Verified 1.36899949326919 0.0854997166537265 no 423 0.0935148964046045 326 NA FT LIPID METABOLISM Phosphatidylethanolamine methyltransferase (PEMT), catalyzes the first step in the conversion of phosphatidylethanolamine to phosphatidylcholine during the methylation pathway of phosphatidylcholine biosynthesis phosphatidylcholine biosynthetic process phosphatidylethanolamine N-methyltransferase activity integral to membrane|endoplasmic reticulum
YOR073W YOR073W SGO1 hom Verified 1.36727720076073 0.085769217584045 no 424 0.103498050083519 365 NA FT PROTEIN LOCALIZATION|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME|CYTOSKELETON KINETOCHORE Component of the spindle checkpoint, involved in sensing lack of tension on mitotic chromosomes; protects centromeric Rec8p at meiosis I; required for accurate chromosomal segregation at meiosis II and for mitotic chromosome stability positive regulation of maintenance of meiotic sister chromatid cohesion|meiotic sister chromatid segregation|meiotic sister chromatid separation|sister chromatid biorientation|maintenance of meiotic sister chromatid cohesion|mitotic cell cycle spindle assembly checkpoint|mitotic sister chromatid segregation molecular_function condensed nuclear chromosome kinetochore|nucleus|spindle pole body|condensed nuclear chromosome, centromeric region
YNL198C_d YNL198C YNL198C hom Dubious 1.36607001732547 0.0859584939741644 no 425 0.0774273720727222 319 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YDR537C_d YDR537C YDR537C hom Dubious 1.35942072396096 0.0870066538852207 no 426 0.0824620041897033 350 NA Dubious open reading frame unlikely to encode a protein, almost completely overlaps verified ORF PAD1/YDR538W Unknown Unknown Unknown
YER044C YER044C ERG28 hom Verified 1.35918711873638 0.087043651021419 no 427 0.0961962152300323 384 NA FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Endoplasmic reticulum membrane protein, may facilitate protein-protein interactions between the Erg26p dehydrogenase and the Erg27p 3-ketoreductase and/or tether these enzymes to the ER, also interacts with Erg6p ergosterol biosynthetic process protein binding, bridging endoplasmic reticulum membrane
YIR028W YIR028W DAL4 hom Verified 1.35246869134058 0.0881127139509414 no 428 0.0814058847487174 324 NA Allantoin permease; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation allantoin catabolic process|allantoin transport allantoin uptake transmembrane transporter activity integral to membrane|membrane
YER119C YER119C AVT6 hom Verified 1.35136744930538 0.0882888777465135 no 429 0.0745704336108075 346 NA FT VACUOLAR TRANSPORT Vacuolar aspartate and glutamate exporter; member of a family of seven genes (AVT1-7) related to vesicular GABA-glycine transporters; involved in compartmentalizing acidic amino acids in response to nitrogen starvation; AVT6 has a paralog, AVT5, that arose from the whole genome duplication amino acid export from vacuole|transmembrane transport L-aspartate transmembrane transporter activity|transporter activity|L-glutamate transmembrane transporter activity fungal-type vacuole membrane|integral to membrane|fungal-type vacuole
YBL075C YBL075C SSA3 hom Verified 1.350606509703 0.0884107572116787 no 430 0.0965091162073004 433 NA FT PROTEIN LOCALIZATION ATPase involved in protein folding and the response to stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasm; SSA3 has a paralog, SSA4, that arose from the whole genome duplication protein folding|SRP-dependent cotranslational protein targeting to membrane, translocation|response to stress unfolded protein binding|ATPase activity cytosol
YPL037C YPL037C EGD1 hom Verified 1.3484426766437 0.0887580227771861 no 431 0.10125284498175 384 NA FT PROTEIN LOCALIZATION NUCLEUS Subunit beta1 of the nascent polypeptide-associated complex (NAC) involved in protein targeting, associated with cytoplasmic ribosomes; enhances DNA binding of the Gal4p activator; homolog of human BTF3b 'de novo' cotranslational protein folding unfolded protein binding nascent polypeptide-associated complex
YJR102C YJR102C VPS25 hom Verified 1.34635752005699 0.0890936218913281 no 432 0.150925357534852 618 NA FF|FT PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|PROTEOLYSIS|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome negative regulation of transcription from RNA polymerase II promoter by glucose|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|protein targeting to vacuole structural molecule activity ESCRT II complex
YFR026C YFR026C ULI1 hom Verified 1.3455087996375 0.0892304907569486 no 433 0.0886859980675556 296 NA FT SIGNALING Putative protein of unknown function involved in and induced by the endoplasmic reticulum unfolded protein response endoplasmic reticulum unfolded protein response molecular_function cellular_component
YPR073C YPR073C LTP1 hom Verified 1.34407840171405 0.0894615177540353 no 434 0.076229750404209 303 NA FT NUCLEUS Protein phosphotyrosine phosphatase of unknown cellular role; activated by adenine protein dephosphorylation protein tyrosine phosphatase activity nucleus|cytoplasm
YNL160W YNL160W YGP1 hom Verified 1.34340634668368 0.0895702164639176 no 435 0.0860260027663974 357 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|CELL WALL ORG/BIOGENESIS Cell wall-related secretory glycoprotein; induced by nutrient deprivation-associated growth arrest and upon entry into stationary phase; may be involved in adaptation prior to stationary phase entry; has similarity to Sps100p cell wall assembly molecular_function extracellular region
YDL202W YDL202W MRPL11 hom Verified 1.34323406871324 0.0895980966471242 no 436 0.0937385295996968 383 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YOR131C YOR131C YOR131C hom Verified 1.34308338819499 0.0896224869493825 no 437 0.103518694325695 400 NA FT NUCLEUS Putative haloacid dehalogenase-like hydrolase; non-essential gene; overexpression causes a cell cycle delay or arrest; protein abundance increases in response to DNA replication stress biological_process molecular_function nucleus|cytoplasm
YPL046C YPL046C ELC1 hom Verified 1.3412043558733 0.0899270562650387 no 438 0.0692449478590308 320 NA FT RESPONSE TO DNA DAMAGE|PROTEOLYSIS NUCLEUS UBIQUITIN LIGASE COMPLEX Elongin C, conserved among eukaryotes; forms a complex with Cul3p that polyubiquitylates monoubiquitylated RNA polymerase II to trigger its proteolysis; plays a role in global genomic repair global genome nucleotide-excision repair|protein ubiquitination involved in ubiquitin-dependent protein catabolic process ubiquitin-protein ligase activity elongin complex|Cul3-RING ubiquitin ligase complex
YNL123W YNL123W NMA111 hom Verified 1.3370588201871 0.0906017188054546 no 439 0.119100013933034 482 NA FT LIPID METABOLISM|PROTEOLYSIS NUCLEUS Serine protease and general molecular chaperone; involved in response to heat stress and promotion of apoptosis; may contribute to lipid homeostasis; sequence similarity to the mammalian Omi/HtrA2 family of serine proteases apoptotic process|cellular lipid metabolic process|protein catabolic process|cellular response to heat serine-type peptidase activity nucleus
YBR296C YBR296C PHO89 hom Verified 1.33670018012841 0.0906602615600766 no 440 0.115388708751908 428 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE Na+/Pi cotransporter, active in early growth phase; similar to phosphate transporters of Neurospora crassa; transcription regulated by inorganic phosphate concentrations and Pho4p; mutations in related human transporter genes hPit1 and hPit2 are associated with hyperphosphatemia-induced calcification of vascular tissue and familial idiopathic basal ganglia calcification phosphate ion transport|transmembrane transport sodium:inorganic phosphate symporter activity integral to membrane|plasma membrane
YLR425W YLR425W TUS1 hom Verified 1.33330280600597 0.0912162266170057 no 441 0.135918716415548 541 NA FT SIGNALING|CELL WALL ORG/BIOGENESIS SITE OF POLARIZED GROWTH Guanine nucleotide exchange factor (GEF) that modulate Rho1p activity; involved in the cell integrity signaling pathway; interacts with Rgl1p; localization of Tus1p to the bed neck is regulated by Rgl1p; multicopy suppressor of tor2 mutation and ypk1 ypk2 double mutation; potential Cdc28p substrate fungal-type cell wall organization|signal transduction Rho guanyl-nucleotide exchange factor activity incipient cellular bud site|cellular bud neck
YIR024C YIR024C YIR024C hom Verified 1.33304900085634 0.0912578619567319 no 442 0.103012555454574 361 NA FT MITOCHONDRION Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; interacts with Arh1p, a mitochondrial oxidoreductase; deletion mutant has a respiratory growth defect biological_process molecular_function mitochondrion
YJL077C YJL077C ICS3 hom Verified 1.32987864034992 0.0917791300180299 no 443 0.0943574301249442 382 NA Protein of unknown function; may play a role in vacuolar sorting, null mutants are hypersensitive to sortin2 biological_process molecular_function cellular_component
YBR114W YBR114W RAD16 hom Verified 1.32978484847258 0.0917945847230588 no 444 0.0967474344752214 379 NA FT RESPONSE TO DNA DAMAGE|PROTEOLYSIS NUCLEUS UBIQUITIN LIGASE COMPLEX Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad7p) during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex nucleotide-excision repair, DNA damage recognition|protein ubiquitination involved in ubiquitin-dependent protein catabolic process ubiquitin-protein ligase activity|damaged DNA binding|DNA-dependent ATPase activity nucleotide-excision repair factor 4 complex|Cul3-RING ubiquitin ligase complex
YFR011C YFR011C AIM13 hom Verified 1.32859556436633 0.0919907181197802 no 445 0.0756664192785246 333 NA FT MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial protein peripheral to the inner membrane; component of the mitochondrial inner membrane organizing system (MINOS, MitOS, or MICOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture cristae formation molecular_function mitochondrion|extrinsic to mitochondrial inner membrane|mitochondrial crista junction|cytoplasm|mitochondrial intermembrane space
YAL067W-A_p YAL067W-A YAL067W-A hom Uncharacterized 1.32856041622945 0.0919965193693692 no 446 0.0827932399057642 338 NA Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching biological_process molecular_function cellular_component
YGR036C YGR036C CAX4 hom Verified 1.32852647642759 0.0920021214386521 no 447 0.0858907465678201 303 NA FT LIPID METABOLISM|CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Dolichyl pyrophosphate (Dol-P-P) phosphatase with a luminally oriented active site in the ER, cleaves the anhydride linkage in Dol-P-P, required for Dol-P-P-linked oligosaccharide intermediate synthesis and protein N-glycosylation lipid biosynthetic process|protein N-linked glycosylation dolichyldiphosphatase activity integral to endoplasmic reticulum membrane|integral to membrane
YNL321W YNL321W VNX1 hom Verified 1.32818865631604 0.0920578954546496 no 448 0.104786958725101 389 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Calcium/H+ antiporter localized to the endoplasmic reticulum membrane; member of the calcium exchanger (CAX) family; potential Cdc28p substrate potassium ion transport|sodium ion transport|hydrogen transport potassium:hydrogen antiporter activity|sodium:hydrogen antiporter activity|calcium:hydrogen antiporter activity fungal-type vacuole membrane|integral to membrane|endoplasmic reticulum membrane|fungal-type vacuole
YOR368W YOR368W RAD17 hom Verified 1.32729446954995 0.0922056462925319 no 449 0.0912452439080418 379 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME Checkpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints; with Mec3p and Ddc1p, forms a clamp that is loaded onto partial duplex DNA; homolog of human and S. pombe Rad1 and U. maydis Rec1 proteins double-strand break repair|reciprocal meiotic recombination|DNA damage checkpoint double-stranded DNA binding nucleus|checkpoint clamp complex
YBR220C_p YBR220C YBR220C hom Uncharacterized 1.32523202092933 0.0925471039597942 no 450 0.0882203421281547 333 NA Putative protein of unknown function; YBR220C is not an essential gene biological_process molecular_function integral to membrane
YKR104W YKR104W YKR104W hom Verified 1.32472650147137 0.0926309399995525 no 451 0.0908659303125507 366 NA FT NUCLEOTIDE METABOLISM Putative transporter of the multidrug resistance-associated protein (MRP) subfamily; contains a stop codon in S288C; adjacent ORFs YKR103W and YKR104W are merged in different strain backgrounds transport ATPase activity, coupled to transmembrane movement of substances integral to membrane|membrane
YOR097C_p YOR097C YOR097C hom Uncharacterized 1.32199381746175 0.0930851048340068 no 452 0.113638886514393 467 NA Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen; YOR097C is not an essential gene biological_process molecular_function cellular_component
YOR247W YOR247W SRL1 hom Verified 1.32194810607287 0.0930927159159174 no 453 0.0985085425874447 371 NA FT CELL WALL ORG/BIOGENESIS SITE OF POLARIZED GROWTH Mannoprotein that exhibits a tight association with the cell wall; required for cell wall stability in the absence of GPI-anchored mannoproteins; has a high serine-threonine content; expression is induced in cell wall mutants; SRL1 has a paralog, SVS1, that arose from the whole genome duplication fungal-type cell wall organization|nucleobase-containing compound metabolic process molecular_function fungal-type cell wall|fungal-type vacuole|cytoplasm|cellular bud tip
YIR043C YIR043C YIR043C hom pseudogene 1.32130369241918 0.0932000616526955 no 454 0.0941267502338625 317 NA Possible pseudogene in strain S288C; YIR043C and the adjacent ORF, YIR044C, together may encode a non-functional member of the conserved, often subtelomerically-encoded Cos protein family biological_process molecular_function cellular_component
YOL052C-A YOL052C-A DDR2 hom Verified 1.32060993403309 0.0933157293941758 no 455 0.0939506898395434 360 NA Multi-stress response protein; expression is activated by a variety of xenobiotic agents and environmental or physiological stresses; DDR2 has a paralog, HOR7, that arose from the whole genome duplication response to stress molecular_function fungal-type vacuole|cytoplasm
YML029W YML029W USA1 hom Verified 1.31946775492687 0.0935063916264563 no 456 0.081456427744956 316 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|PROTEOLYSIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM UBIQUITIN LIGASE COMPLEX Scaffold subunit of the Hrd1p ubiquitin ligase that also promotes ligase oligomerization; involved in ER-associated protein degradation (ERAD); interacts with the U1 snRNP-specific protein, Snp1p ER-associated protein catabolic process|mRNA splicing, via spliceosome|positive regulation of protein oligomerization protein complex scaffold Hrd1p ubiquitin ligase ERAD-L complex|endoplasmic reticulum membrane
YLR335W YLR335W NUP2 hom Verified 1.31583140919943 0.0941153172900448 no 457 0.095741761133789 396 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RNA LOCALIZATION|GENE SILENCING ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION|CHROMOSOME NUCLEAR PORE Nucleoporin involved in nucleocytoplasmic transport, binds to either the nucleoplasmic or cytoplasmic faces of the nuclear pore complex depending on Ran-GTP levels; also has a role in chromatin organization rRNA export from nucleus|snRNA export from nucleus|nuclear pore organization|tRNA export from nucleus|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|mRNA-binding (hnRNP) protein import into nucleus|ribosomal protein import into nucleus|snRNP protein import into nucleus|chromatin silencing at telomere|chromatin silencing at silent mating-type cassette|protein targeting to membrane|poly(A)+ mRNA export from nucleus|protein export from nucleus|mRNA export from nucleus in response to heat stress|transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery|NLS-bearing substrate import into nucleus|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, non-stop decay nucleocytoplasmic transporter activity nuclear chromatin|mitochondrion|integral to membrane|nuclear pore
YPR185W YPR185W ATG13 hom Verified 1.31528919155542 0.0942063646219241 no 458 0.0812510608342581 330 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|PROTEIN PHOSPHORYLATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS Regulatory subunit of the Atg1p signaling complex; stimulates Atg1p kinase activity; required for vesicle formation during autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; involved in Atg9p, Atg23p, and Atg27p cycling piecemeal microautophagy of nucleus|mitochondrion degradation|macroautophagy|activation of protein kinase activity|CVT pathway protein kinase regulator activity Atg1p signaling complex|extrinsic to membrane
YGL038C YGL038C OCH1 hom Verified 1.31477669851659 0.0942924804113768 no 459 0.118361344026421 422 NA FT CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS Mannosyltransferase of the cis-Golgi apparatus, initiates the polymannose outer chain elongation of N-linked oligosaccharides of glycoproteins protein N-linked glycosylation alpha-1,6-mannosyltransferase activity|transferase activity, transferring glycosyl groups Golgi cis cisterna
YMR142C YMR142C RPL13B hom Verified 1.31382228916883 0.0944530074799279 no 460 0.106559859884898 417 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L13B; not essential for viability; homologous to mammalian ribosomal protein L13, no bacterial homolog; RPL13B has a paralog, RPL13A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YKL031W_d YKL031W YKL031W hom Dubious 1.31225027342903 0.094717852119655 no 461 0.0999724579386536 333 NA Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species Unknown Unknown Unknown
YHR037W YHR037W PUT2 hom Verified 1.31065901691167 0.0949864953304217 no 462 0.111309429935416 423 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS MITOCHONDRION Delta-1-pyrroline-5-carboxylate dehydrogenase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; deficiency of the human homolog causes HPII, an autosomal recessive inborn error of metabolism glutamate biosynthetic process|proline catabolic process to glutamate 1-pyrroline-5-carboxylate dehydrogenase activity mitochondrion|mitochondrial matrix
YMR242W-A_p YMR242W-A YMR242W-A hom Uncharacterized 1.30972849819892 0.095143849612647 no 463 0.0924633737825885 370 NA Putative protein of unknown function biological_process molecular_function cellular_component
YAR050W YAR050W FLO1 hom Verified 1.30823447818792 0.0953968955454355 no 464 0.114232114477608 393 NA FT PLASMA MEMBRANE Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p cellular response to stress|flocculation via cell wall protein-carbohydrate interaction|flocculation mannose binding fungal-type cell wall
YER055C YER055C HIS1 hom Verified 1.30802893408735 0.095431747799007 no 465 0.0964345528633949 364 NA FT KETONE METABOLISM|AMINO ACID METABOLISM ATP phosphoribosyltransferase, a hexameric enzyme, catalyzes the first step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control histidine biosynthetic process ATP phosphoribosyltransferase activity cellular_component
YGR221C YGR221C TOS2 hom Verified 1.30772463564483 0.0954833621403045 no 466 0.0857255398405869 364 NA FT CELL DIVISION SITE OF POLARIZED GROWTH|PLASMA MEMBRANE Protein involved in localization of Cdc24p to the site of bud growth; may act as a membrane anchor; localizes to the bud neck and bud tip; potentially phosphorylated by Cdc28p budding cell bud growth molecular_function cellular bud neck|cellular bud tip
YOR180C YOR180C DCI1 hom Verified 1.30674791680753 0.0956491695584077 no 467 0.117302612706706 444 NA FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS Peroxisomal protein; identification as a delta(3,5)-delta(2,4)-dienoyl-CoA isomerase involved in fatty acid metabolism is disputed fatty acid beta-oxidation dodecenoyl-CoA delta-isomerase activity peroxisomal matrix
YIL159W YIL159W BNR1 hom Verified 1.30126729718625 0.0965834885073229 no 468 0.0923642884114385 353 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNI1 barbed-end actin filament capping|actin filament bundle assembly|formin-nucleated actin cable assembly profilin binding cellular bud neck
YLR098C YLR098C CHA4 hom Verified 1.30005855767282 0.0967904500216175 no 469 0.100948149848793 350 NA FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS DNA binding transcriptional activator, mediates serine/threonine activation of the catabolic L-serine (L-threonine) deaminase (CHA1); Zinc-finger protein with Zn[2]-Cys[6] fungal-type binuclear cluster domain positive regulation of transcription, DNA-dependent|cellular amino acid catabolic process sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity nucleus
YKL161C YKL161C KDX1 hom Verified 1.29660994191329 0.0973827149772021 no 470 0.119000760826901 418 NA FT PROTEIN PHOSPHORYLATION Protein kinase implicated in the Slt2p mitogen-activated (MAP) kinase signaling pathway; interacts with numerous components in the mating pheromone and CWI MAPK pathways; associates with Rlm1p biological_process protein kinase activity cellular_component
YKL202W_d YKL202W YKL202W hom Dubious 1.29549591641157 0.0975746045791127 no 471 0.0703704069371025 248 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YGR093W_p YGR093W YGR093W hom Uncharacterized 1.29483206618539 0.0976890837803724 no 472 0.0920980751038977 354 NA FT NUCLEUS Putative protein of unconfirmed function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus biological_process molecular_function nucleus
YLR432W YLR432W IMD3 hom Verified 1.29363992263072 0.0978949129136089 no 473 0.125904913717799 472 NA FT OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, member of a four-gene family in S. cerevisiae, constitutively expressed GTP biosynthetic process IMP dehydrogenase activity plasma membrane|cytoplasm
YPL032C YPL032C SVL3 hom Verified 1.29216463415531 0.0981500681686444 no 474 0.131084480238417 488 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|OXIDATION-REDUCTION PROCESS SITE OF POLARIZED GROWTH Protein of unknown function; mutant phenotype suggests a potential role in vacuolar function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; relocalizes from bud neck to cytoplasm upon DNA replication stress endocytosis molecular_function cellular bud|cellular bud neck|cytoplasm
YML101C-A_d YML101C-A YML101C-A hom Dubious 1.29167363576915 0.0982350956733408 no 475 0.0866719115506084 337 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YDR223W YDR223W CRF1 hom Verified 1.29162676638537 0.0982432149901226 no 476 0.0987131307884839 364 NA FT TRANSCRIPTION FROM RNA POL II|RIBOSOME BIOGENESIS NUCLEUS|CHROMOSOME Transcriptional corepressor involved in repression of ribosomal protein (RP) gene transcription via the TOR signaling pathway which promotes accumulation of Crf1p in the nucleus; role in repression of RP genes varies by strain negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter transcription corepressor activity nuclear chromatin|nucleus|cytoplasm
YJR052W YJR052W RAD7 hom Verified 1.29095114864523 0.0983603087917054 no 477 0.0942843925432683 326 NA FT RESPONSE TO DNA DAMAGE|PROTEOLYSIS NUCLEUS UBIQUITIN LIGASE COMPLEX Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad16p) during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex nucleotide-excision repair, DNA damage recognition|protein ubiquitination involved in ubiquitin-dependent protein catabolic process damaged DNA binding|ubiquitin-protein ligase activity|DNA-dependent ATPase activity nucleotide-excision repair factor 4 complex|Cul3-RING ubiquitin ligase complex
YCR008W YCR008W SAT4 hom Verified 1.29028466142786 0.0984759202592369 no 478 0.0987708545736569 425 NA FT PROTEIN LOCALIZATION|CELL CYCLE|ION HOMEOSTASIS|PROTEIN PHOSPHORYLATION|ION HOMEOSTASIS Ser/Thr protein kinase involved in salt tolerance; funtions in regulation of Trk1p-Trk2p potassium transporter; partially redundant with Hal5p; has similarity to Npr1p cellular cation homeostasis|protein phosphorylation|cellular protein localization|G1/S transition of mitotic cell cycle|protein dephosphorylation protein kinase activity cellular_component
YNR029C_p YNR029C YNR029C hom Uncharacterized 1.28845442612299 0.0987939117006168 no 479 0.0833307592839846 394 NA Putative protein of unknown function, deletion confers reduced fitness in saline biological_process molecular_function cytoplasm
YIL156W YIL156W UBP7 hom Verified 1.28811694319299 0.0988526291178285 no 480 0.101587046179872 351 NA FT PROTEOLYSIS Ubiquitin-specific protease that cleaves ubiquitin-protein fusions protein deubiquitination ubiquitin-specific protease activity cytoplasm
YMR144W_p YMR144W YMR144W hom Uncharacterized 1.28567474496726 0.0992782993731444 no 481 0.0945545208350091 370 NA FT NUCLEUS Putative protein of unknown function; localized to the nucleus; YMR144W is not an essential gene biological_process molecular_function nucleus
YBR105C YBR105C VID24 hom Verified 1.28459155193767 0.0994675261855401 no 482 0.110860769508492 422 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|KETONE METABOLISM|MEMBRANE ORGANIZATION|CARBOHYDRATE METABOLISM|PROTEOLYSIS|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM GID Complex regulatory subunit; binds GID Complex in response to glucose through interactions with complex member Vid28p; regulates fructose-1,6-bisphosphatase (FBPase) targeting to the vacuole; promotes proteasome-dependent catabolite degradation of FBPase; peripheral membrane protein located at Vid (vacuole import and degradation) vesicles negative regulation of gluconeogenesis|vesicle fusion with vacuole|vacuolar protein catabolic process|proteasomal ubiquitin-dependent protein catabolic process|vesicle-mediated transport|protein targeting to vacuole molecular_function cytoplasmic membrane-bounded vesicle|GID complex|extrinsic to membrane
YKL094W YKL094W YJU3 hom Verified 1.28403385765185 0.0995650545107439 no 483 0.0973437647245676 351 NA FT LIPID METABOLISM ENDOPLASMIC RETICULUM|MITOCHONDRION Monoglyceride lipase (MGL), functional ortholog of mammalian MGL, localizes to lipid particles and membranes, also member of the eukaryotic serine hydrolase family triglyceride metabolic process serine hydrolase activity|acylglycerol lipase activity mitochondrial outer membrane|lipid particle|plasma membrane|membrane|cytoplasm
YJL053W YJL053W PEP8 hom Verified 1.28261440161637 0.0998136010512794 no 484 0.113458739040625 465 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM Vacuolar protein component of the retromer; forms part of the multimeric membrane-associated retromer complex involved in vacuolar protein sorting along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport; interacts with Ypt7p; protein abundance increases in response to DNA replication stress protein retention in Golgi apparatus|retrograde transport, endosome to Golgi protein transporter activity endosome|retromer complex, inner shell|retromer complex
YDL074C YDL074C BRE1 hom Verified 1.28179380576838 0.0999574938434326 no 485 0.166802429944978 555 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING NUCLEUS|CHROMOSOME E3 ubiquitin ligase, forms heterodimer with Rad6p to monoubiquinate histone H2B-K123, which is required for the subsequent methylation of histone H3-K4 and H3-K79; required for DSBR, transcription, silencing, and checkpoint control mitotic cell cycle G1/S transition DNA damage checkpoint|intra-S DNA damage checkpoint|meiotic DNA double-strand break formation|histone monoubiquitination|double-strand break repair via homologous recombination|transcription from RNA polymerase II promoter|chromatin silencing at telomere ubiquitin-protein ligase activity nuclear chromatin
YOR177C YOR177C MPC54 hom Verified 1.28103572475462 0.100090559124128 no 486 0.108167793172009 428 NA FT VESICLE-MEDIATED TRANSPORT|CELL CYCLE|CELL WALL ORG/BIOGENESIS|CELL DIVISION NUCLEUS|CYTOSKELETON Component of the meiotic outer plaque, a membrane-organizing center which is assembled on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane; potential Cdc28p substrate ascospore wall assembly|vesicle docking structural molecule activity spindle pole body
YKR005C_p YKR005C YKR005C hom Uncharacterized 1.27938062206069 0.100381527152411 no 487 0.0927467459323429 393 NA Putative protein of unknown function biological_process molecular_function cellular_component
YLR325C YLR325C RPL38 hom Verified 1.27798812307946 0.100626807025071 no 488 0.122258002246342 405 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L38; homologous to mammalian ribosomal protein L38, no bacterial homolog cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YDR205W YDR205W MSC2 hom Verified 1.27638937730314 0.100908954725226 no 489 0.109024337078107 425 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids cellular zinc ion homeostasis|zinc ion transport|transmembrane transport zinc ion transmembrane transporter activity|metal ion transmembrane transporter activity integral to membrane|endoplasmic reticulum
YBR284W_p YBR284W YBR284W hom Uncharacterized 1.27553164098448 0.10106056611593 no 490 0.103842843254506 435 NA FT NUCLEOTIDE METABOLISM Putative metallo-dependent hydrolase superfamily protein; similar to AMP deaminases but lacks key catalytic residues and does not rescue purine nucleotide metabolic defect of quadruple aah1 ade8 amd1 his1 mutant; null mutant exhibits longer telomeres, altered Ty mobility, decreased resistance to rapamycin and wortmannin; induced in response to hydrostatic pressure; not an essential gene; YBR284W has a paralog, YJL070C, that arose from the whole genome duplication biological_process AMP deaminase activity|molecular_function cellular_component
YMR100W YMR100W MUB1 hom Verified 1.27474614243761 0.101199554518383 no 491 0.118181868530661 419 NA FT CELL DIVISION MYND domain-containing protein required for ubiquitination and turnover of Rpn4p; interacts with Ubr2p (E3) and indirectly with Rad6p (E2); short-lived protein degraded in a Ubr2p/Rad6p dependent manner; similar to the A. nidulans samB gene regulation of cell budding|protein monoubiquitination molecular_function cellular_component
YDR401W_d YDR401W YDR401W hom Dubious 1.27278890704379 0.101546479288549 no 492 0.111088738274446 372 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YHR171W YHR171W ATG7 hom Verified 1.2661612500066 0.102727678794107 no 493 0.147352577928553 508 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS MITOCHONDRION Autophagy-related protein and dual specificity member of the E1 family of ubiquitin-activating enzymes; mediates the conjugation of Atg12p with Atg5p and Atg8p with phosphatidylethanolamine, required steps in autophagosome formation C-terminal protein lipidation|protein modification by small protein conjugation|piecemeal microautophagy of nucleus|mitochondrion degradation|macroautophagy|CVT pathway APG8 activating enzyme activity|APG12 activating enzyme activity cytosol|mitochondrion|membrane|pre-autophagosomal structure
YLR263W YLR263W RED1 hom Verified 1.26404754337289 0.103106481458492 no 494 0.0797017574249027 303 NA FT CELL CYCLE|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME Protein component of the synaptonemal complex axial elements, involved in chromosome segregation during the first meiotic division; critical for coupling checkpoint signaling to SC formation; interacts with Hop1p, Mec3p and Ddc1p synaptonemal complex assembly|meiotic recombination checkpoint|positive regulation of catalytic activity chromatin DNA binding|structural molecule activity lateral element
YNR041C YNR041C COQ2 hom Verified 1.26306644127326 0.103282651537347 no 495 0.101706241567868 356 NA FT KETONE METABOLISM|LIPID METABOLISM|COFACTOR METABOLISM MITOCHONDRION Para hydroxybenzoate: polyprenyl transferase, catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis ubiquinone biosynthetic process 4-hydroxybenzoate octaprenyltransferase activity mitochondrion|integral to mitochondrial membrane|integral to membrane
YLL010C YLL010C PSR1 hom Verified 1.26227162555257 0.103425531553242 no 496 0.110669192823428 446 NA FT PLASMA MEMBRANE Plasma membrane associated protein phosphatase involved in the general stress response; required along with binding partner Whi2p for full activation of STRE-mediated gene expression, possibly through dephosphorylation of Msn2p response to stress phosphoprotein phosphatase activity plasma membrane
YNL323W YNL323W LEM3 hom Verified 1.2569081657401 0.104393445659835 no 497 0.197788597722397 709 NA FF|FT MEMBRANE ORGANIZATION|SIGNALING ENDOPLASMIC RETICULUM|PLASMA MEMBRANE Membrane protein of the plasma membrane and ER, interacts specifically in vivo with the phospholipid translocase (flippase) Dnf1p; involved in translocation of phospholipids and alkylphosphocholine drugs across the plasma membrane phospholipid translocation|cell surface receptor signaling pathway phospholipid-translocating ATPase activity integral to membrane|endoplasmic reticulum|plasma membrane|cytoplasm
YGR200C YGR200C ELP2 hom Verified 1.25578696871573 0.104596608750255 no 498 0.125754725431751 462 NA FT PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|RNA PROCESSING NUCLEUS Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; target of Kluyveromyces lactis zymocin regulation of transcription from RNA polymerase II promoter|protein urmylation|tRNA wobble uridine modification molecular_function Elongator holoenzyme complex|nucleus|cytoplasm
YDR447C YDR447C RPS17B hom Verified 1.25404770609325 0.104912333029789 no 499 0.107751969889335 407 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Ribosomal protein 51 (rp51) of the small (40s) subunit; homologous to mammalian ribosomal protein S17, no bacterial homolog; RPS17B has a paralog, RPS17A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress cytoplasmic translation|ribosomal small subunit assembly structural constituent of ribosome cytosolic small ribosomal subunit
YLL029W YLL029W FRA1 hom Verified 1.25379097445507 0.104958995301054 no 500 0.11796160904908 446 NA FT TRANSCRIPTION FROM RNA POL II|PROTEOLYSIS Protein involved in negative regulation of transcription of iron regulon; forms an iron independent complex with Fra2p, Grx3p, and Grx4p; cytosolic; mutant fails to repress transcription of iron regulon and is defective in spore formation negative regulation of transcription from RNA polymerase II promoter in response to iron molecular_function cytosol|cytoplasm
YBL080C YBL080C PET112 hom Verified 1.25349371194809 0.105013043029532 no 501 0.137427909906309 513 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; mutation is functionally complemented by the bacterial GatB ortholog glutaminyl-tRNAGln biosynthesis via transamidation|mitochondrial translation glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity mitochondrion|glutamyl-tRNA(Gln) amidotransferase complex
YNL328C YNL328C MDJ2 hom Verified 1.25304767352477 0.105094178712865 no 502 0.124578114305088 430 NA FT PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Constituent of the mitochondrial import motor associated with the presequence translocase; function overlaps with that of Pam18p; stimulates the ATPase activity of Ssc1p to drive mitochondrial import; contains a J domain protein import into mitochondrial matrix protein transporter activity|ATPase activator activity mitochondrial inner membrane|presequence translocase-associated import motor
YOR308C YOR308C SNU66 hom Verified 1.25241422500141 0.10520948279137 no 503 0.106787597108759 388 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Component of the U4/U6.U5 snRNP complex involved in pre-mRNA splicing via spliceosome; also required for pre-5S rRNA processing and may act in concert with Rnh70p; has homology to human SART-1 maturation of 5S rRNA|mRNA splicing, via spliceosome molecular_function U4/U6 x U5 tri-snRNP complex
YJL077W-B_p YJL077W-B YJL077W-B hom Uncharacterized 1.2504715318955 0.105563674177253 no 504 0.143807881030171 451 NA Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching biological_process molecular_function cellular_component
YDR333C YDR333C RQC1 hom Verified 1.24899230991848 0.105833943274271 no 505 0.0914188756723164 297 NA Component of the ribosome quality control complex (RQC); RQC (Rqc1p-Ltn1p-Tae2p-Cdc48p-Npl4p-Ufd1p), is a ribosome-bound complex required for the degradation of polypeptides arising from stalled translation; required along with Ltn1p for recruitment of the Cdc48p-Npl4p-Ufd1p AAA ATPase complex to the RQC biological_process molecular_function cytoplasm
YNL116W YNL116W DMA2 hom Verified 1.2484107345718 0.105940339942775 no 506 0.137620008106077 490 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION Ubiquitin-protein ligase (E3); controls septin dynamics and the spindle position checkpoint (SPOC) along with functionally redundant ligase Dma1p by regulating the recruitment of Elm1p to the bud neck; regulates levels of the translation initiation factor eIF2 subunit Gcd11p, as well as abundance, localization, and ubiquitination of Cdk inhibitory kinase Swe1p; ortholog of human RNF8 protein, with sequence similarity to human Chfr; contains FHA and RING finger domains establishment of mitotic spindle orientation|protein autoubiquitination|septin ring assembly|mitotic cell cycle spindle assembly checkpoint ubiquitin-protein ligase activity cytoplasm
YCL044C YCL044C MGR1 hom Verified 1.24549228091961 0.106475425586711 no 507 0.0959869267666194 319 NA FT PROTEOLYSIS MITOCHONDRION Subunit of the mitochondrial (mt) i-AAA protease supercomplex, which degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr3p that binds to substrates to facilitate proteolysis; required for growth of cells lacking mtDNA misfolded or incompletely synthesized protein catabolic process misfolded protein binding mitochondrion|i-AAA complex
YPR120C YPR120C CLB5 hom Verified 1.24450858593127 0.106656220683337 no 508 0.124856364777283 471 NA FT CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION NUCLEUS B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1 phase spindle assembly|G1/S transition of mitotic cell cycle|regulation of S phase of mitotic cell cycle|G2/M transition of mitotic cell cycle|regulation of cyclin-dependent protein kinase activity|positive regulation of spindle pole body separation|premeiotic DNA replication|positive regulation of DNA replication cyclin-dependent protein kinase regulator activity nucleus
YDL066W YDL066W IDP1 hom Verified 1.24438995048292 0.106678039872261 no 509 0.182329018025366 660 NA FF|FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes isocitrate metabolic process|glutamate biosynthetic process isocitrate dehydrogenase (NADP+) activity mitochondrial nucleoid|mitochondrion
YMR176W YMR176W ECM5 hom Verified 1.24376742752131 0.106792585827376 no 510 0.103831615496462 398 NA FT CELL WALL ORG/BIOGENESIS NUCLEUS|CHROMOSOME Non-essential protein of unknown function; contains ATP/GTP-binding site motif A; null mutant exhibits cellular volume up to four times greater than wild-type, also large drooping buds with elongated necks; relative distribution to the nucleus increases upon DNA replication stress fungal-type cell wall organization molecular_function nucleus|Snt2C complex
YPL096W YPL096W PNG1 hom Verified 1.24159667011628 0.107192705489084 no 511 0.11558929955898 397 NA FT RESPONSE TO DNA DAMAGE|PROTEOLYSIS NUCLEUS|MITOCHONDRION Conserved peptide N-glycanase required for deglycosylation of misfolded glycoproteins during proteasome-dependent degradation; localizes to the cytoplasm and nucleus; activity is enhanced by interaction with Rad23p misfolded or incompletely synthesized protein catabolic process|protein deglycosylation peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity cytosol|mitochondrion|nucleus
YIL035C YIL035C CKA1 hom Verified 1.24060511618918 0.107375830513176 no 512 0.115879933057928 461 NA FT RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION NUCLEUS Alpha catalytic subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases; regulates Fkh1p-mediated donor preference during mating-type switching regulation of transcription from RNA polymerase I promoter|protein phosphorylation|regulation of transcription from RNA polymerase III promoter|response to DNA damage stimulus protein serine/threonine kinase activity|protein kinase activity protein kinase CK2 complex|UTP-C complex
YGL125W YGL125W MET13 hom Verified 1.23960746611553 0.107560308892179 no 513 0.116204063626749 358 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS MITOCHONDRION Major isozyme of methylenetetrahydrofolate reductase, catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate in the methionine biosynthesis pathway methionine biosynthetic process methylenetetrahydrofolate reductase (NADPH) activity mitochondrion
YML036W YML036W CGI121 hom Verified 1.23950729578712 0.107578844288857 no 514 0.128957724095196 448 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS|CHROMOSOME Component of the EKC/KEOPS complex with Bud32p, Kae1p, Pcc1p, and Gon7p; EKC/KEOPS complex is required for t6A tRNA modification and may have roles in telomere maintenance and transcription; Cgi121p is dispensable for tRNA modification telomere maintenance|positive regulation of transcription from RNA polymerase II promoter molecular_function EKC/KEOPS complex
YNL237W YNL237W YTP1 hom Verified 1.23846414469469 0.107772004507202 no 515 0.172541440278559 632 NA FF|FT MITOCHONDRION Probable type-III integral membrane protein of unknown function, has regions of similarity to mitochondrial electron transport proteins biological_process molecular_function integral to membrane|membrane
YMR173W-A_d YMR173W-A YMR173W-A hom Dubious 1.23688556370831 0.108064785133314 no 516 0.121546050059265 446 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene DDR48/YML173W Unknown Unknown Unknown
YPL064C YPL064C CWC27 hom Verified 1.23685782086408 0.108069935735394 no 517 0.122611277925559 437 NA FT RNA PROCESSING NUCLEUS Component of a complex containing Cef1p; putatively involved in pre-mRNA splicing; has similarity to S. pombe Cwf27p; protein abundance increases in response to DNA replication stress biological_process molecular_function U2-type spliceosomal complex
YMR022W YMR022W UBC7 hom Verified 1.23531917636979 0.108355869799728 no 518 0.129787701615203 443 NA FT CHROMATIN ORGANIZATION|CELL WALL ORG/BIOGENESIS|PROTEOLYSIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly fungal-type cell wall organization|chromatin assembly or disassembly|ER-associated protein catabolic process ubiquitin-protein ligase activity endoplasmic reticulum membrane
YGR153W_p YGR153W YGR153W hom Uncharacterized 1.23397290806008 0.108606499840465 no 519 0.103370248648028 391 NA Putative protein of unknown function biological_process molecular_function cellular_component
YMR088C YMR088C VBA1 hom Verified 1.23394784900018 0.108611168947282 no 520 0.105149354757667 374 NA Permease of basic amino acids in the vacuolar membrane basic amino acid transport basic amino acid transmembrane transporter activity fungal-type vacuole membrane|integral to membrane
YIL148W YIL148W RPL40A hom Verified 1.22882860468553 0.109568037147669 no 521 0.115127842458234 411 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RESPONSE TO DNA DAMAGE|TRANSLATION NUCLEUS RIBOSOME Ubiquitin-ribosomal 60S subunit protein L40A fusion protein; cleaved to yield ubiquitin and ribosomal protein L40A; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; homologous to mammalian ribosomal protein L40, no bacterial homolog; RPL40A has a paralog, RPL40B, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress cytoplasmic translation|protein ubiquitination|ribosome biogenesis structural constituent of ribosome|protein tag cytosolic large ribosomal subunit
YOR173W YOR173W DCS2 hom Verified 1.22608062836911 0.110084167442627 no 522 0.108298309096019 416 NA Non-essential, stress induced regulatory protein; modulates m7G-oligoribonucleotide metabolism; inhibits Dcs1p; regulated by Msn2p, Msn4p, and the Ras-cAMP-cAPK signaling pathway; mutant has increased aneuploidy tolerance deadenylation-dependent decapping of nuclear-transcribed mRNA m7G(5')pppN diphosphatase activity cytoplasmic mRNA processing body|cytoplasm
YER129W YER129W SAK1 hom Verified 1.22491979802149 0.110302720094165 no 523 0.124531339744529 456 NA FT CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION Upstream serine/threonine kinase for the SNF1 complex; partially redundant with Elm1p and Tos3p; members of this family have functional orthology with LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome protein phosphorylation|glucose metabolic process|DNA-dependent DNA replication protein serine/threonine kinase activity|protein kinase activity cytoplasm
YKL156W YKL156W RPS27A hom Verified 1.22374370724446 0.110524463014008 no 524 0.121606425596715 406 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S27, no bacterial homolog; RPS27A has a paralog, RPS27B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress cytoplasmic translation|ribosomal small subunit assembly|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) structural constituent of ribosome cytosolic small ribosomal subunit|cytoplasm
YPR173C YPR173C VPS4 hom Verified 1.22329935035159 0.110608326227229 no 525 0.145937375407665 537 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|LIPID METABOLISM|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT ENDOPLASMIC RETICULUM AAA-ATPase involved in multivesicular body (MVB) protein sorting, ATP-bound Vps4p localizes to endosomes and catalyzes ESCRT-III disassembly and membrane release; ATPase activity is activated by Vta1p; regulates cellular sterol metabolism late endosome to vacuole transport via multivesicular body sorting pathway|protein retention in Golgi apparatus|intralumenal vesicle formation|protein homooligomerization|sterol metabolic process|late endosome to vacuole transport ATPase activity|protein homodimerization activity|ATP binding endosome|endoplasmic reticulum|membrane|cytoplasm
YFL041W-A_p YFL041W-A YFL041W-A hom Uncharacterized 1.22185455172292 0.110881317422451 no 526 0.111293284939467 388 NA Putative protein of unknown function; identified by fungal homology and RT-PCR biological_process molecular_function cellular_component
YJL046W YJL046W AIM22 hom Verified 1.22078590699498 0.111083545560034 no 527 0.109553255557078 390 NA FT MITOCHONDRION Putative lipoate-protein ligase, required along with Lip2 and Lip5 for lipoylation of Lat1p and Kgd2p; similar to E. coli LplA; null mutant displays reduced frequency of mitochondrial genome loss protein lipoylation lipoate-protein ligase activity mitochondrion
YDR028C YDR028C REG1 hom Verified 1.22031468781341 0.111172801975184 no 528 0.215611850783227 758 NA FF|FT TRANSCRIPTION FROM RNA POL II|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS|GEN. OF PRECURSOR METABOLITES AND ENERGY NUCLEUS Regulatory subunit of type 1 protein phosphatase Glc7p; involved in negative regulation of glucose-repressible genes; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p cellular response to glucose starvation|vacuolar protein catabolic process|glycogen metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of carbohydrate metabolic process protein phosphatase type 1 regulator activity protein phosphatase type 1 complex|cytoplasm
YLR280C_d YLR280C YLR280C hom Dubious 1.21327173735726 0.11251297238881 no 529 0.0910652503236132 304 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YPL048W YPL048W CAM1 hom Verified 1.21219222761434 0.112719403000341 no 530 0.115832134524991 429 NA FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION NUCLEUS Nuclear protein required for transcription of MXR1; binds the MXR1 promoter in the presence of other nuclear factors; binds calcium and phospholipids; has similarity to translational cofactor EF-1 gamma ribosome biogenesis|positive regulation of transcription from RNA polymerase II promoter phospholipid binding|transcription coactivator activity|calcium ion binding nucleus
YML087C YML087C AIM33 hom Verified 1.21114219949203 0.112920455284826 no 531 0.104747198273325 359 NA FT OXIDATION-REDUCTION PROCESS Putative protein of unknown function, highly conserved across species; homolog of human CYB5R4; null mutant displays reduced frequency of mitochondrial genome loss; AIM33 has a paralog, PGA3, that arose from the whole genome duplication biological_process molecular_function cellular_component
YPL225W YPL225W YPL225W hom Verified 1.20912588073359 0.11330724380298 no 532 0.130139587793865 506 NA Protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress biological_process molecular_function ribosome|cytoplasm
YOR209C YOR209C NPT1 hom Verified 1.20862411328614 0.113403644058545 no 533 0.168494546729347 618 NA FF|FT NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|GENE SILENCING|RESPONSE TO OXIDATIVE STRESS NUCLEUS Nicotinate phosphoribosyltransferase, acts in the salvage pathway of NAD+ biosynthesis; required for silencing at rDNA and telomeres and has a role in silencing at mating-type loci; localized to the nucleus chromatin silencing at rDNA|replicative cell aging|nicotinate nucleotide salvage|chromatin silencing at telomere nicotinate phosphoribosyltransferase activity nucleus
YGR069W_d YGR069W YGR069W hom Dubious 1.20598606574034 0.113911431616161 no 534 0.131049186365855 464 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YFR057W_p YFR057W YFR057W hom Uncharacterized 1.20290546672103 0.114506452311461 no 535 0.127094991722461 411 NA Putative protein of unknown function biological_process molecular_function cellular_component
YLR439W YLR439W MRPL4 hom Verified 1.20160342733319 0.114758606483607 no 536 0.154369674659747 541 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit, homolog of prokaryotic L29 ribosomal protein; located at the ribosomal tunnel exit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YMR320W_d YMR320W YMR320W hom Dubious 1.20109819375093 0.114856556807194 no 537 0.102127145036911 429 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YIR025W YIR025W MND2 hom Verified 1.2007884590234 0.114916634898963 no 538 0.127671091946304 497 NA FT CELL CYCLE|CELL DIVISION|PROTEOLYSIS|CHROMOSOME SEGREGATION NUCLEUS UBIQUITIN LIGASE COMPLEX Subunit of the anaphase-promoting complex (APC); necessary for maintaining sister chromatid cohesion in prophase I of meiosis by inhibiting premature ubiquitination and subsequent degradation of substrates by the APC(Ama1) ubiquitin ligase anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|reciprocal meiotic recombination|regulation of mitotic metaphase/anaphase transition|protein ubiquitination|mitotic sister chromatid segregation molecular_function nucleus|anaphase-promoting complex
YJR008W YJR008W MHO1 hom Verified 1.19823797183144 0.115412193336997 no 539 0.107400975650324 407 NA FT NUCLEUS Protein of unknown function; inhibits haploid invasive growth when overexpressed; synthetically lethal with phospholipase C (PLC1); expression induced by mild heat-stress on a non-fermentable carbon source, upon entry into stationary phase and upon nitrogen deprivation; repressed by inosine and choline in an Opi1p-dependent manner; highly conserved from bacteria to human; Memo, the human homolog, is an ErbB2 interacting protein with an essential function in cell motility biological_process molecular_function nucleus|cytoplasm
YPR128C YPR128C ANT1 hom Verified 1.19741904263233 0.115571632518882 no 540 0.122909098384762 463 NA FT KETONE METABOLISM|LIPID METABOLISM|ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|PEROXISOME ORGANIZATION Peroxisomal adenine nucleotide transporter; involved in beta-oxidation of medium-chain fatty acid; required for peroxisome proliferation ATP transport|fatty acid beta-oxidation|peroxisome organization adenine nucleotide transmembrane transporter activity integral to membrane|cytoplasm|integral to peroxisomal membrane
YFL042C_p YFL042C YFL042C hom Uncharacterized 1.19613815742113 0.115821324648326 no 541 0.121500504794021 375 NA Putative protein of unknown function; YFL042C is not an essential gene biological_process molecular_function cellular_component
YPL081W YPL081W RPS9A hom Verified 1.19576610130183 0.115893923958688 no 542 0.117070741819251 471 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION NUCLEUS RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S9 and bacterial S4; RPS9A has a paralog, RPS9B, that arose from the whole genome duplication cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) structural constituent of ribosome|rRNA binding small-subunit processome|cytosolic small ribosomal subunit|90S preribosome|cytoplasm
YGR040W YGR040W KSS1 hom Verified 1.19574630960406 0.115897786817603 no 543 0.105042136959415 410 NA FT CELL CYCLE|SIGNALING|PROTEIN PHOSPHORYLATION NUCLEUS Mitogen-activated protein kinase (MAPK) involved in signal transduction pathways that control filamentous growth and pheromone response; the KSS1 gene is nonfunctional in S288C strains and functional in W303 strains pheromone-dependent signal transduction involved in conjugation with cellular fusion|signal transduction involved in filamentous growth|negative regulation of sequence-specific DNA binding transcription factor activity|protein phosphorylation|invasive growth in response to glucose limitation MAP kinase activity|protein kinase activity|transcription factor binding nucleus
YJR077C YJR077C MIR1 hom Verified 1.19128686186345 0.116770494895802 no 544 0.11183342868197 434 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; functionally redundant with Pic2p but more abundant than Pic2p under normal conditions; phosphorylated phosphate ion transmembrane transport inorganic phosphate transmembrane transporter activity mitochondrion|integral to membrane|integral to mitochondrial inner membrane
YOR200W_d YOR200W YOR200W hom Dubious 1.18939806231233 0.117141531487761 no 545 0.168897437838874 611 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MRM1/YOR201c Unknown Unknown Unknown
YER014W YER014W HEM14 hom Verified 1.18804991817105 0.117406871840289 no 546 0.144318645814691 518 NA FT OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM MITOCHONDRION Protoporphyrinogen oxidase, a mitochondrial enzyme that catalyzes the seventh step in the heme biosynthetic pathway, converting protoporphyrinogen IX to protoporphyrin IX; inhibited by diphenyl ether-type herbicides heme biosynthetic process oxygen-dependent protoporphyrinogen oxidase activity mitochondrion|mitochondrial inner membrane
YMR177W YMR177W MMT1 hom Verified 1.18671929714804 0.117669180379273 no 547 0.120096711737643 455 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION Putative metal transporter involved in mitochondrial iron accumulation; closely related to Mmt2p cellular iron ion homeostasis molecular_function mitochondrion|integral to membrane
YNL072W YNL072W RNH201 hom Verified 1.18650334950944 0.117711789750702 no 548 0.228747571166222 772 NA FT NUCLEUS Ribonuclease H2 catalytic subunit, removes RNA primers during Okazaki fragment synthesis and errant ribonucleotides misincorporated during DNA replication; homolog of RNAse HI; related to human AGS4 which causes Aicardi-Goutieres syndrome DNA replication, removal of RNA primer ribonuclease H activity ribonuclease H2 complex|nucleus
YDL091C YDL091C UBX3 hom Verified 1.18611832319135 0.117787787707806 no 549 0.0946922097665083 333 NA Subunit of the DSC ubiquitin ligase complex; UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; ortholog of fission yeast Ucp10 biological_process molecular_function cytoplasm
YEL059W_d YEL059W HHY1 hom Dubious 1.18568001040014 0.117874345805995 no 550 0.103233147081522 370 NA Dubious open reading frame unlikely to encode a functional protein; mutant is hypersensitive to hygromycin B indicative of defects in vacuolar trafficking Unknown Unknown Unknown
YMR124W_p YMR124W YMR124W hom Uncharacterized 1.18510706028832 0.117987559961158 no 551 0.102451363533421 389 NA Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene; predicted to have a role in organelle organization biological_process molecular_function cytoplasm
YOL138C YOL138C RTC1 hom Verified 1.18471576528817 0.118064923507557 no 552 0.120622529224954 461 NA Subunit of the SEA (Seh1-associated) complex, a coatomer-related complex that associates dynamically with the vacuole; null mutation suppresses cdc13-1 temperature sensitivity; has N-terminal WD-40 repeats and a C-terminal RING motif biological_process molecular_function ribosome|fungal-type vacuole|Seh1-associated complex|extrinsic to fungal-type vacuolar membrane
YJR049C YJR049C UTR1 hom Verified 1.18464490304802 0.118078937628112 no 553 0.144456966864574 530 NA FF|FT ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS|COFACTOR METABOLISM NUCLEUS ATP-NADH kinase; phosphorylates both NAD and NADH; active as a hexamer; enhances the activity of ferric reductase (Fre1p); UTR1 has a paralog, YEF1, that arose from the whole genome duplication cellular iron ion homeostasis|NADP biosynthetic process NAD+ kinase activity|NADH kinase activity nucleus|cytoplasm
YGR168C_p YGR168C YGR168C hom Uncharacterized 1.18419285333892 0.118168365247878 no 554 0.155658555101179 584 NA Putative protein of unknown function; YGR168C is not an essential gene biological_process molecular_function integral to membrane
YMR286W YMR286W MRPL33 hom Verified 1.17955876937612 0.119087874796732 no 555 0.121383383383195 486 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YER034W YER034W YER034W hom Verified 1.17776702961137 0.119444748078582 no 556 0.130629099767148 461 NA FT NUCLEUS Protein of unknown function; non-essential gene; expression induced upon calcium shortage; protein abundance increases in response to DNA replication stress biological_process molecular_function nucleus|cytoplasm
YLL052C YLL052C AQY2 hom Verified 1.17280637788276 0.120436729965274 no 557 0.130571223442061 475 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|PLASMA MEMBRANE Water channel that mediates the transport of water across cell membranes, only expressed in proliferating cells, controlled by osmotic signals, may be involved in freeze tolerance; disrupted by a stop codon in many S. cerevisiae strains water transport water channel activity plasma membrane|endoplasmic reticulum membrane
YOR014W YOR014W RTS1 hom Verified 1.17143511906453 0.120711961424603 no 558 0.153492261213781 605 NA FT PROTEIN LOCALIZATION|CELL CYCLE|SIGNALING|CHROMOSOME SEGREGATION NUCLEUS|SITE OF POLARIZED GROWTH|CHROMOSOME|CYTOSKELETON B-type regulatory subunit of protein phosphatase 2A (PP2A); Rts1p and Cdc55p are alternative regulatory subunits for PP2A catalytic subunits, Pph21p and Pph22p; PP2A-Rts1p protects cohesin when recruited by Sgo1p to the pericentromere; highly enriched at centromeres in the absence of Cdc55p; required for maintenance of septin ring organization during cytokinesis, for ring disassembly in G1 and for dephosphorylation of septin, Shs1p; homolog of the mammalian B' subunit of PP2A mitotic cell cycle spindle orientation checkpoint|cellular protein localization|meiotic sister chromatid cohesion, centromeric|protein dephosphorylation protein serine/threonine phosphatase activity nucleus|spindle pole body|condensed nuclear chromosome, centromeric region|cellular bud neck|cytoplasm
YGR108W YGR108W CLB1 hom Verified 1.17063971011038 0.12087181425046 no 559 0.107074445913319 428 NA FT CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION NUCLEUS B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome G2/M transition of mitotic cell cycle|meiotic G2/MI transition|regulation of cyclin-dependent protein kinase activity|mitotic spindle organization in nucleus|positive regulation of spindle pole body separation cyclin-dependent protein kinase regulator activity cyclin-dependent protein kinase holoenzyme complex|nucleus|cytoplasm
YPR093C YPR093C ASR1 hom Verified 1.16911762458039 0.121178121961053 no 560 0.116871664532275 426 NA FT NUCLEUS Ubiquitin ligase that modifies and regulates RNA Pol II; involved in a putative alcohol-responsive signaling pathway; accumulates in the nucleus under alcohol stress; contains a Ring/PHD finger domain similar to the mammalian rA9 protein response to ethanol|protein ubiquitination ubiquitin-protein ligase activity nucleus|cytoplasm
YGR066C_p YGR066C YGR066C hom Uncharacterized 1.16746170157937 0.121511983040599 no 561 0.136768428270789 447 NA Putative protein of unknown function biological_process molecular_function cellular_component
YJL120W_d YJL120W YJL120W hom Dubious 1.16714139222255 0.121576637190052 no 562 0.186347832019506 668 NA FF Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL121C/RPE1; deletion confers sensitivity to GSAO Unknown Unknown Unknown
YOR356W YOR356W CIR2 hom Verified 1.16689330247378 0.121626730491431 no 563 0.117377183926987 435 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Putative ortholog of human electron transfer flavoprotein dehydrogenase (ETF-dH); found in a large supramolecular complex with other mitochondrial dehydrogenases; may have a role in oxidative stress response biological_process molecular_function mitochondrion
YCR010C YCR010C ADY2 hom Verified 1.16418484568151 0.122174555118478 no 564 0.140005235320948 496 NA FT CELL CYCLE|ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION|PLASMA MEMBRANE Acetate transporter required for normal sporulation; phosphorylated in mitochondria; ADY2 has a paralog, ATO2, that arose from the whole genome duplication nitrogen utilization|ammonium transport|acetate transport|transmembrane transport acetate transmembrane transporter activity|ammonium transmembrane transporter activity mitochondrion|integral to membrane|plasma membrane
YPL087W YPL087W YDC1 hom Verified 1.16365460817261 0.122282005797422 no 565 0.103240467239311 398 NA FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS Alkaline dihydroceramidase, involved in sphingolipid metabolism; preferentially hydrolyzes dihydroceramide to a free fatty acid and dihydrosphingosine; has a minor reverse activity; YDC1 has a paralog, YPC1, that arose from the whole genome duplication ceramide catabolic process|ceramide biosynthetic process dihydroceramidase activity integral to membrane|endoplasmic reticulum
YOR127W YOR127W RGA1 hom Verified 1.16235834716954 0.122544967579367 no 566 0.125198881229939 454 NA FT SIGNALING|CELL DIVISION|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH|CYTOSKELETON GTPase-activating protein for polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth; relocalizes from bud neck to cytoplasm upon DNA replication stress budding cell isotropic bud growth|pheromone-dependent signal transduction involved in conjugation with cellular fusion|pseudohyphal growth|actin filament organization|establishment of cell polarity|small GTPase mediated signal transduction|invasive growth in response to glucose limitation|budding cell apical bud growth Rho GTPase activator activity cellular bud neck split septin rings
YLR287C-A YLR287C-A RPS30A hom Verified 1.16232430367285 0.12255187904563 no 567 0.125273484404388 482 NA FT TRANSLATION RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S30, no bacterial homolog; RPS30A has a paralog, RPS30B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic small ribosomal subunit|cytoplasmic stress granule
YFL028C YFL028C CAF16 hom Verified 1.16185408298885 0.122647370613433 no 568 0.110814603789769 403 NA FT TRANSCRIPTION FROM RNA POL II|NUCLEOTIDE METABOLISM NUCLEUS Part of evolutionarily-conserved CCR4-NOT regulatory complex; contains single ABC-type ATPase domain but no transmembrane domain; interacts with several subunits of Mediator regulation of transcription from RNA polymerase II promoter ATPase activity CCR4-NOT complex|cytoplasm
YMR018W_p YMR018W YMR018W hom Uncharacterized 1.16047522124951 0.12292768826526 no 569 0.140418327515995 482 NA FT PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION Putative protein of unknown function with similarity to human PEX5Rp (peroxin protein 5 related protein); transcription increases during colony development similar to genes involved in peroxisome biogenesis; YMR018W is not an essential gene biological_process molecular_function cellular_component
YJL068C YJL068C YJL068C hom Verified 1.16018949624479 0.122985831277442 no 570 0.104577354360714 388 NA Non-essential intracellular esterase that can function as an S-formylglutathione hydrolase; may be involved in the detoxification of formaldehyde, which can be metabolized to S-formylglutathione; similar to human esterase D formaldehyde catabolic process S-formylglutathione hydrolase activity cytosol
YHL029C_p YHL029C OCA5 hom Uncharacterized 1.15851137247853 0.123327706708776 no 571 0.153274506907717 566 NA FT SIGNALING|NUCLEOTIDE METABOLISM Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts biological_process molecular_function cytoplasm
YLR240W YLR240W VPS34 hom Verified 1.15785786373144 0.123461022620259 no 572 0.132682370224474 534 NA FT PROTEIN LOCALIZATION|LIPID METABOLISM|SIGNALING|PROTEIN PHOSPHORYLATION|PEROXISOME ORGANIZATION GOLGI APPARATUS Phosphatidylinositol (PI) 3-kinase that synthesizes PI-3-phosphate; forms membrane-associated signal transduction complex with Vps15p to regulate protein sorting; activated by the GTP-bound form of Gpa1p; a fraction is localized, with Vps15p, to nuclear pores at nucleus-vacuole junctions and may facilitate transcription elongation for genes positioned at the nuclear periphery peroxisome degradation|phosphatidylinositol phosphorylation|protein phosphorylation 1-phosphatidylinositol-3-kinase activity|protein kinase activity endosome|fungal-type vacuole membrane|phosphatidylinositol 3-kinase complex I|phosphatidylinositol 3-kinase complex II|peroxisome|pre-autophagosomal structure
YOR164C YOR164C GET4 hom Verified 1.15760380392352 0.123512878111196 no 573 0.140726893786287 482 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION Protein with a role in insertion of tail-anchored proteins into the ER membrane; forms a complex with Mdy2p; highly conserved across species and homologous to human gene C7orf20 protein insertion into ER membrane|posttranslational protein targeting to membrane molecular_function TRC complex|cytoplasm
YJL071W YJL071W ARG2 hom Verified 1.15722784735643 0.123589641621095 no 574 0.106774990103089 431 NA FT KETONE METABOLISM|AMINO ACID METABOLISM MITOCHONDRION Acetylglutamate synthase (glutamate N-acetyltransferase), mitochondrial enzyme that catalyzes the first step in the biosynthesis of the arginine precursor ornithine; forms a complex with Arg5,6p arginine biosynthetic process|ornithine biosynthetic process acetyl-CoA:L-glutamate N-acetyltransferase activity mitochondrial matrix
YCR044C YCR044C PER1 hom Verified 1.15441195530881 0.124165658023565 no 575 0.232723588729092 764 NA FF|FT LIPID METABOLISM|ION HOMEOSTASIS|ION HOMEOSTASIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Protein of the endoplasmic reticulum, required for GPI-phospholipase A2 activity that remodels the GPI anchor as a prerequisite for association of GPI-anchored proteins with lipid rafts; functionally complemented by human ortholog PERLD1 GPI anchor biosynthetic process|cellular manganese ion homeostasis molecular_function fungal-type vacuole membrane|integral to membrane|endoplasmic reticulum
YKL121W_p YKL121W DGR2 hom Uncharacterized 1.15341243257973 0.12437057044986 no 576 0.127128078343429 427 NA Protein of unknown function; null mutant is resistant to 2-deoxy-D-glucose and displays abnormally elongated buds biological_process molecular_function cellular_component
YGL260W_p YGL260W YGL260W hom Uncharacterized 1.15320290840826 0.124413555022937 no 577 0.106920050312719 395 NA Putative protein of unknown function; transcription is significantly increased in a NAP1 deletion background; deletion mutant has increased accumulation of nickel and selenium biological_process molecular_function cellular_component
YKL106W YKL106W AAT1 hom Verified 1.1529078115175 0.12447411273823 no 578 0.107064664703332 425 NA FT KETONE METABOLISM|AMINO ACID METABOLISM MITOCHONDRION Mitochondrial aspartate aminotransferase, catalyzes the conversion of oxaloacetate to aspartate in aspartate and asparagine biosynthesis aspartate catabolic process|chronological cell aging|replicative cell aging|asparagine biosynthetic process from oxaloacetate|aspartate biosynthetic process L-aspartate:2-oxoglutarate aminotransferase activity mitochondrion
YIL006W YIL006W YIA6 hom Verified 1.15181903899493 0.124697721285361 no 579 0.135579560911954 466 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION Mitochondrial NAD+ transporter, involved in the transport of NAD+ into the mitochondria (see also YEA6); member of the mitochondrial carrier subfamily; disputed role as a pyruvate transporter; has putative mouse and human orthologs transport|mitochondrial pyruvate transport|NAD transmembrane transport pyruvate secondary active transmembrane transporter activity|transporter activity|NAD transporter activity mitochondrion|integral to membrane|mitochondrial inner membrane
YGR275W YGR275W RTT102 hom Verified 1.15167670073279 0.124726974990637 no 580 0.140318953673287 431 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|CHROMOSOME SEGREGATION NUCLEUS RSC COMPLEX Component of both the SWI/SNF and RSC chromatin remodeling complexes; suggested role in chromosome maintenance; possible weak regulator of Ty1 transposition; protein abundance increases in response to DNA replication stress chromosome segregation|nucleosome disassembly|chromatin remodeling|transcription elongation from RNA polymerase II promoter molecular_function RSC complex|SWI/SNF complex|nucleus
YKL135C YKL135C APL2 hom Verified 1.15147101519448 0.124769256454422 no 581 0.166241481197868 523 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS|PLASMA MEMBRANE Beta-adaptin subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in clathrin-dependent Golgi protein sorting; protein abundance increases in response to DNA replication stress Golgi to vacuole transport|vesicle-mediated transport clathrin binding AP-1 adaptor complex
YJL160C_p YJL160C YJL160C hom Uncharacterized 1.14927529941157 0.1252212399661 no 582 0.157552326660396 539 NA Putative protein of unknown function; member of the PIR (proteins with internal repeats) family of cell wall proteins; non-essential gene that is required for sporulation; mRNA is weakly cell cycle regulated, peaking in mitosis; YJL160C has a paralog, PIR1, that arose from the whole genome duplication biological_process molecular_function cellular_component
YDL083C YDL083C RPS16B hom Verified 1.14796072026702 0.125492389830921 no 583 0.152689297566015 495 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S16 and bacterial S9; RPS16B has a paralog, RPS16A, that arose from the whole genome duplication cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) structural constituent of ribosome cytosolic small ribosomal subunit
YNR067C YNR067C DSE4 hom Verified 1.14149965546226 0.126831027644486 no 584 0.103575549156621 405 NA FT CELL WALL ORG/BIOGENESIS|CELL DIVISION Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother cytokinesis, completion of separation glucan endo-1,3-beta-D-glucosidase activity fungal-type cell wall|extracellular region|cell septum
YOR002W YOR002W ALG6 hom Verified 1.14110349538709 0.126913428447775 no 585 0.176688108638944 661 NA FT LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Alpha 1,3 glucosyltransferase, involved in transfer of oligosaccharides from dolichyl pyrophosphate to asparagine residues of proteins during N-linked protein glycosylation; mutations in human ortholog are associated with disease oligosaccharide-lipid intermediate biosynthetic process|protein glycosylation|aerobic respiration transferase activity, transferring hexosyl groups|dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity integral to membrane|endoplasmic reticulum
YNL009W YNL009W IDP3 hom Verified 1.13953218913731 0.127240625195725 no 586 0.122781614608821 416 NA FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION Peroxisomal NADP-dependent isocitrate dehydrogenase; catalyzes oxidation of isocitrate to alpha-ketoglutarate with the formation of NADP(H+), required for growth on unsaturated fatty acids; IDP3 has a paralog, IDP2, that arose from the whole genome duplication NADPH regeneration|fatty acid beta-oxidation|isocitrate metabolic process isocitrate dehydrogenase (NADP+) activity mitochondrion|peroxisome|cytoplasm
YOR008C YOR008C SLG1 hom Verified 1.13812187930092 0.127534796623718 no 587 0.201728213201221 727 NA FF|FT VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|SIGNALING|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION|PEROXISOME ORGANIZATION SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON Sensor-transducer of the stress-activated PKC1-MPK1 kinase pathway; involved in maintenance of cell wall integrity; required for mitophagy; involved in organization of the actin cytoskeleton; secretory pathway Wsc1p is required for the arrest of secretion response positive regulation of endocytosis|Rho protein signal transduction|actin cytoskeleton organization|fungal-type cell wall organization|response to heat|peroxisome degradation|establishment of cell polarity|response to osmotic stress transmembrane signaling receptor activity plasma membrane|mating projection tip|cellular bud neck
YHL035C YHL035C VMR1 hom Verified 1.13728203123159 0.127710201979048 no 588 0.134124166861452 481 NA FT NUCLEOTIDE METABOLISM MITOCHONDRION Vacuolar membrane protein involved in multiple drug resistance and metal sensitivity; ATP-binding cassette (ABC) family member involved in drug transport; potential Cdc28p substrate; induced under respiratory conditions transport|response to drug|response to metal ion|drug transport ATPase activity, coupled to transmembrane movement of substances fungal-type vacuole membrane|mitochondrion|integral to membrane|ribosome
YCR105W YCR105W ADH7 hom Verified 1.13255680310518 0.128700208779767 no 589 0.152921726591491 492 NA FT OXIDATION-REDUCTION PROCESS NADPH-dependent medium chain alcohol dehydrogenase with broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance alcohol metabolic process alcohol dehydrogenase (NADP+) activity cellular_component
YKL146W YKL146W AVT3 hom Verified 1.13120001082521 0.12898545869724 no 590 0.130419313639951 457 NA FT VACUOLAR TRANSPORT Vacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters amino acid export from vacuole transporter activity|L-glutamine transmembrane transporter activity|L-isoleucine transmembrane transporter activity|L-tyrosine transmembrane transporter activity fungal-type vacuole membrane|integral to membrane
YCL050C YCL050C APA1 hom Verified 1.13103412557089 0.129020364213175 no 591 0.127225275154483 442 NA FT NUCLEOTIDE METABOLISM NUCLEUS AP4A phosphorylase; bifunctional diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase and ADP sulfurylase involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; catalyzes phosphorolysis of dinucleoside oligophosphates, cleaving substrates' alpha/beta-anhydride bond and introducing Pi into the beta-position of the corresponding NDP formed; protein abundance increases under DNA replication stress; APA1 has a paralog, APA2, that arose from the whole genome duplication nucleotide biosynthetic process|nucleoside catabolic process bis(5'-nucleosyl)-tetraphosphatase activity|sulfate adenylyltransferase (ADP) activity nucleus|cytoplasm
YIL028W_d YIL028W YIL028W hom Dubious 1.1279965450238 0.129660689130823 no 592 0.142646447006343 447 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YOR290C YOR290C SNF2 hom Verified 1.12773248476453 0.129716457096768 no 593 0.216989856416252 758 NA FF|FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS NUCLEUS RSC COMPLEX Catalytic subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; contains DNA-stimulated ATPase activity; functions interdependently in transcriptional activation with Snf5p and Snf6p cellular alcohol catabolic process|ATP-dependent chromatin remodeling|double-strand break repair|strand invasion|positive regulation of mating type switching|sucrose catabolic process|positive regulation of transcription from RNA polymerase II promoter in response to amino acid starvation|nucleosome mobilization|chromatin remodeling|DNA-dependent DNA replication|positive regulation of transcription from RNA polymerase II promoter histone acetyl-lysine binding|RNA polymerase II activating transcription factor binding|DNA-dependent ATPase activity|nucleosomal DNA binding SWI/SNF complex|nucleus
YPL034W_p YPL034W YPL034W hom Uncharacterized 1.12643156835807 0.129991445454624 no 594 0.142799864607782 513 NA Putative protein of unknown function; YPL034W is not essential gene biological_process molecular_function cellular_component
YPL215W YPL215W CBP3 hom Verified 1.12609276696814 0.130063127643015 no 595 0.104874086671348 425 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex positive regulation of mitochondrial translation|mitochondrial respiratory chain complex III assembly ribosome binding integral to mitochondrial membrane|mitochondrion|mitochondrial ribosome
YGR011W_d YGR011W YGR011W hom Dubious 1.12438686147108 0.130424471678496 no 596 0.111985481458108 390 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YLR398C YLR398C SKI2 hom Verified 1.12360028967904 0.130591316587673 no 597 0.137980719114501 482 NA FT TRANSLATION Ski complex component and putative RNA helicase, mediates 3'-5' RNA degradation by the cytoplasmic exosome; null mutants have superkiller phenotype of increased viral dsRNAs and are synthetic lethal with mutations in 5'-3' mRNA decay nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'|nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay|nuclear-transcribed mRNA catabolic process, non-stop decay RNA helicase activity Ski complex
YCR099C_p YCR099C YCR099C hom Uncharacterized 1.12355063905245 0.130601853257792 no 598 0.145144170896047 561 NA Putative protein of unknown function biological_process molecular_function integral to membrane
YMR119W-A_d YMR119W-A YMR119W-A hom Dubious 1.12240569304092 0.130844992493019 no 599 0.130443240566913 440 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YHR100C YHR100C GEP4 hom Verified 1.12232326301885 0.130862509288671 no 600 0.200622035584977 690 NA FF|FT LIPID METABOLISM|CARBOHYDRATE METABOLISM MITOCHONDRION Mitochondrial phosphatidylglycerophosphatase (PGP phosphatase), dephosphorylates phosphatidylglycerolphosphate to generate phosphatidylglycerol, an essential step during cardiolipin biosynthesis; null mutant is sensitive to tunicamycin, DTT cardiolipin biosynthetic process|phosphorylated carbohydrate dephosphorylation phosphatidylglycerophosphatase activity mitochondrion|mitochondrial matrix
YFL048C YFL048C EMP47 hom Verified 1.12200945027603 0.130929210909268 no 601 0.126255020517978 486 NA FT VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport ER to Golgi vesicle-mediated transport glycoprotein binding fungal-type vacuole membrane|integral to endoplasmic reticulum membrane|integral to Golgi membrane|ER to Golgi transport vesicle
YEL056W YEL056W HAT2 hom Verified 1.12090980146426 0.131163129178915 no 602 0.108606842521493 407 NA FT CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING NUCLEUS HISTONE ACETYLTRANSFERASE Subunit of the Hat1p-Hat2p histone acetyltransferase complex; required for high affinity binding of the complex to free histone H4, thereby enhancing Hat1p activity; similar to human RbAp46 and 48; has a role in telomeric silencing histone acetylation|chromatin assembly or disassembly|chromatin silencing at telomere histone acetyltransferase activity|histone binding histone acetyltransferase complex|nucleus|cytoplasm
YLR283W_p YLR283W YLR283W hom Uncharacterized 1.12012926344006 0.13132934098553 no 603 0.114638982523539 430 NA FT MITOCHONDRION Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR283W is not an essential gene biological_process molecular_function mitochondrion
YMR187C_p YMR187C YMR187C hom Uncharacterized 1.11889955805395 0.131591495772953 no 604 0.127869565231709 476 NA Putative protein of unknown function; YMR187C is not an essential gene biological_process molecular_function integral to membrane
YCL001W-B_p YCL001W-B YCL001W-B hom Uncharacterized 1.11705088814364 0.131986283766154 no 605 0.144573446954225 466 NA Putative protein of unknown function; present in a region duplicated between chromosomes XIV and III; YCL001W-B has a paralog, DOM34, that arose from the whole genome duplication biological_process molecular_function cellular_component
YPR171W YPR171W BSP1 hom Verified 1.11392975367972 0.132654661887214 no 606 0.134892568916401 469 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON Adapter that links synaptojanins Inp52p and Inp53p to the cortical actin cytoskeleton actin cortical patch localization protein binding, bridging mating projection tip|membrane|cellular bud neck|actin cortical patch|cellular bud tip
YGR279C YGR279C SCW4 hom Verified 1.11329448601116 0.132790986912934 no 607 0.137880693472864 492 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM Cell wall protein with similarity to glucanases; scw4 scw10 double mutants exhibit defects in mating conjugation with cellular fusion glucosidase activity extracellular region|fungal-type cell wall
YOR092W YOR092W ECM3 hom Verified 1.11245986130333 0.132970239487793 no 608 0.12469344397 384 NA FT CELL WALL ORG/BIOGENESIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Non-essential protein of unknown function; involved in signal transduction and the genotoxic response; induced rapidly in response to treatment with 8-methoxypsoralen and UVA irradiation; relocalizes from ER to cytoplasm upon DNA replication stress; ECM3 has a paralog, YNL095C, that arose from the whole genome duplication fungal-type cell wall organization ATPase activity integral to membrane|endoplasmic reticulum
YGR219W_d YGR219W YGR219W hom Dubious 1.10943063278146 0.133622226823657 no 609 0.158115878244691 494 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MRPL9/YGR220C Unknown Unknown Unknown
YKR059W YKR059W TIF1 hom Verified 1.10905584931863 0.133703044815412 no 610 0.132112821972007 455 NA FT TRANSLATION RIBOSOME Translation initiation factor eIF4A; DEA(D/H)-box RNA helicase that couples ATPase activity to RNA binding and unwinding; forms a dumbbell structure of two compact domains connected by a linker; interacts with eIF4G; protein abundance increases in response to DNA replication stress; TIF1 has a paralog, TIF2, that arose from the whole genome duplication translational initiation ATP-dependent RNA helicase activity|translation initiation factor activity ribosome|eukaryotic translation initiation factor 4F complex
YPL036W YPL036W PMA2 hom Verified 1.10865856489292 0.133788751581826 no 611 0.104804643477395 343 NA FT ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS MITOCHONDRION|PLASMA MEMBRANE Plasma membrane H+-ATPase, isoform of Pma1p, involved in pumping protons out of the cell; regulator of cytoplasmic pH and plasma membrane potential proton transport|regulation of pH hydrogen-exporting ATPase activity, phosphorylative mechanism mitochondrion|integral to membrane|plasma membrane
YPL148C YPL148C PPT2 hom Verified 1.10725098443865 0.134092714925382 no 612 0.191677544831544 675 NA FF|FT KETONE METABOLISM|LIPID METABOLISM MITOCHONDRION Phosphopantetheine:protein transferase (PPTase), activates mitochondrial acyl carrier protein (Acp1p) by phosphopantetheinylation protein-cofactor linkage holo-[acyl-carrier-protein] synthase activity mitochondrion
YPL092W YPL092W SSU1 hom Verified 1.1056626407703 0.134436282970492 no 613 0.136292655170369 413 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE Plasma membrane sulfite pump involved in sulfite metabolism and required for efficient sulfite efflux; major facilitator superfamily protein sulfite transport sulfite transmembrane transporter activity integral to membrane|plasma membrane
YAL042C-A_d YAL042C-A YAL042C-A hom Dubious 1.10498128379592 0.134583849557489 no 614 0.135160580056424 487 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF ERV46/YAL042W; YAL042C-A is a non-essential gene Unknown Unknown Unknown
YEL047C YEL047C FRD1 hom Verified 1.10381853998121 0.134835930376142 no 615 0.131164171309703 493 NA FT OXIDATION-REDUCTION PROCESS MITOCHONDRION Soluble fumarate reductase; required with isoenzyme Osm1p for anaerobic growth; may interact with ribosomes, based on co-purification experiments; authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; similar to Arxula adeninovorans fumarate reductase; protein abundance increases in response to DNA replication stress; FRD1 has a paralog, OSM1, that arose from the whole genome duplication cellular response to anoxia fumarate reductase (NADH) activity cytosol|mitochondrion|ribosome|plasma membrane
YLR396C YLR396C VPS33 hom Verified 1.10377518481744 0.134845335959851 no 616 0.154026857527079 510 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT ATP-binding protein that is a subunit of the HOPS complex and of the CORVET tethering complex; essential for protein sorting, vesicle docking and fusion at the vacuole regulation of SNARE complex assembly|endocytosis|regulation of vacuole fusion, non-autophagic|piecemeal microautophagy of nucleus|vesicle fusion with vacuole|Golgi to vacuole transport|vacuole organization|vacuole fusion, non-autophagic|vesicle docking|protein targeting to vacuole phosphatidylinositol binding|ATP binding cytosol|fungal-type vacuole membrane|HOPS complex|fungal-type vacuole|CORVET complex
YCR032W YCR032W BPH1 hom Verified 1.10270938648148 0.135076694612469 no 617 0.137112113213054 526 NA FT PROTEIN LOCALIZATION|CELL WALL ORG/BIOGENESIS MITOCHONDRION Protein homologous to Chediak-Higashi syndrome and Beige proteins; both of which are implicated in disease syndromes in human and mouse, respectively, due to defective lysosomal trafficking; mutant phenotype and genetic interactions suggest a role in protein sorting intracellular protein transport|fungal-type cell wall organization|response to pH molecular_function cytosol|mitochondrion|extrinsic to membrane
YGR112W YGR112W SHY1 hom Verified 1.10266406102748 0.135086539686528 no 618 0.104735640824875 373 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Mitochondrial inner membrane protein required for assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes; similar to human SURF1 involved in Leigh Syndrome mitochondrial respiratory chain complex IV assembly|aerobic respiration unfolded protein binding mitochondrion|integral to membrane|mitochondrial inner membrane
YGR273C_p YGR273C YGR273C hom Uncharacterized 1.10257049145231 0.135106865350385 no 619 0.142702802471939 523 NA Putative protein of unknown function; expression downregulated by treatment with 8-methoxypsoralen plus UVA irradiation; YGR273C is not an essential gene biological_process molecular_function cellular_component
YNL097C-B_p YNL097C-B YNL097C-B hom Uncharacterized 1.10218918955708 0.135189715392236 no 620 0.111775834627115 390 NA Putative protein of unknown function biological_process molecular_function cellular_component
YPL196W YPL196W OXR1 hom Verified 1.10188613130802 0.135255589337348 no 621 0.12233146584107 510 NA FT RESPONSE TO OXIDATIVE STRESS MITOCHONDRION Protein of unknown function required for normal levels of resistance to oxidative damage, null mutants are sensitive to hydrogen peroxide; member of a conserved family of proteins found in eukaryotes cellular response to oxidative stress molecular_function mitochondrion
YDR452W YDR452W PPN1 hom Verified 1.1015847259584 0.135321125823336 no 622 0.177369478862938 486 NA FT NUCLEUS Vacuolar endopolyphosphatase with a role in phosphate metabolism; functions as a homodimer; relocalizes from vacuole to cytoplasm upon DNA replication stress polyphosphate catabolic process|polyphosphate metabolic process endopolyphosphatase activity|exopolyphosphatase activity fungal-type vacuole membrane|nucleus
YDL167C YDL167C NRP1 hom Verified 1.0995548868129 0.13576305356306 no 623 0.146612712716893 489 NA Putative RNA binding protein of unknown function; localizes to stress granules induced by glucose deprivation; predicted to be involved in ribosome biogenesis biological_process molecular_function cytoplasmic stress granule|cytoplasm
YDR463W YDR463W STP1 hom Verified 1.09903809115149 0.135875725754391 no 624 0.228841050642162 723 NA FT TRANSCRIPTION FROM RNA POL II|RNA PROCESSING NUCLEUS|PLASMA MEMBRANE Transcription factor; undergoes proteolytic processing by SPS (Ssy1p-Ptr3p-Ssy5p)-sensor component Ssy5p in response to extracellular amino acids; activates transcription of amino acid permease genes and may have a role in tRNA processing; STP1 has a paralog, STP2, that arose from the whole genome duplication positive regulation of transcription, DNA-dependent|tRNA splicing, via endonucleolytic cleavage and ligation|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription plasma membrane|nucleus|cytoplasm
YHR182W YHR182W YHR182W hom Verified 1.09801073021443 0.136099901905481 no 625 0.157043619999294 473 NA FT SIGNALING Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and cytoplasm; relocalizes from bud neck to cytoplasm upon DNA replication stress biological_process molecular_function cytoplasm
YCL039W YCL039W GID7 hom Verified 1.09727369643834 0.136260882846222 no 626 0.13183778985107 460 NA FT KETONE METABOLISM|CARBOHYDRATE METABOLISM|PROTEOLYSIS NUCLEUS Subunit of GID Complex that binds directly to central component Vid30p; GID complex is involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; Gid7p contains six WD40 repeats; computational analysis suggests that Gid7p and Moh1p have similar functions negative regulation of gluconeogenesis|proteasomal ubiquitin-dependent protein catabolic process molecular_function nucleus|GID complex|cytoplasm
YDR138W YDR138W HPR1 hom Verified 1.09649584542934 0.13643092023932 no 627 0.201784049116501 676 NA FT TRANSCRIPTION FROM RNA POL II|RNA PROCESSING|RESPONSE TO DNA DAMAGE|RNA LOCALIZATION NUCLEUS RNA POL II, HOLOENZYME Subunit of THO/TREX complexes that couple transcription elongation with mitotic recombination and with mRNA metabolism and export, subunit of an RNA Pol II complex; regulates lifespan; involved in telomere maintenance; similar to Top1p mRNA 3'-end processing|mRNA export from nucleus|transcription-coupled nucleotide-excision repair|DNA recombination|response to DNA damage stimulus|transcription elongation from RNA polymerase II promoter protein complex scaffold|nucleic acid binding THO complex part of transcription export complex|Cdc73/Paf1 complex|nucleoplasmic THO complex
YGL163C YGL163C RAD54 hom Verified 1.09633283063169 0.13646657348717 no 628 0.199264145265269 657 NA FF|FT CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE NUCLEUS DNA-dependent ATPase that stimulates strand exchange; modifies the topology of double-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; member of the SWI/SNF family; forms nuclear foci upon DNA replication stress positive regulation of endodeoxyribonuclease activity|DNA geometric change|heteroduplex formation|telomere maintenance via recombination|double-strand break repair via synthesis-dependent strand annealing|chromatin remodeling|double-strand break repair via single-strand annealing DNA-dependent ATPase activity|DNA translocase activity nucleus
YBL024W YBL024W NCL1 hom Verified 1.09610653694337 0.136516077133553 no 629 0.174395805343358 566 NA FT RNA PROCESSING NUCLEUS S-adenosyl-L-methionine-dependent tRNA: m5C-methyltransferase, methylates cytosine to m5C at several positions in tRNAs and intron-containing pre-tRNAs; increases proportion of tRNALeu(CAA) with m5C at wobble position in response to hydrogen peroxide, causing selective translation of mRNA from genes enriched in TTG codon; loss of NCL1 confers hypersensitivity to oxidative stress; similar to Nop2p and human proliferation associated nucleolar protein p120 tRNA methylation tRNA (cytosine-5-)-methyltransferase activity nucleus
YDL172C_d YDL172C YDL172C hom Dubious 1.09563441281289 0.136619397793863 no 630 0.159874014720832 574 NA Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YDR206W YDR206W EBS1 hom Verified 1.09503969942383 0.136749622234324 no 631 0.143051389456835 402 NA FT TRANSLATION NUCLEUS|CHROMOSOME Protein involved in inhibition of translation and nonsense-mediated decay; interacts with cap binding protein Cdc33p and with Nam7p; localizes to P-bodies upon glucose starvation; mRNA abundance regulated by mRNA decay factors negative regulation of translation|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay molecular_function cytoplasmic mRNA processing body|cytoplasm
YDR032C YDR032C PST2 hom Verified 1.0925147599045 0.137303453238483 no 632 0.122468373400367 476 NA FT OXIDATION-REDUCTION PROCESS MITOCHONDRION Protein with similarity to a family of flavodoxin-like proteins; induced by oxidative stress in a Yap1p dependent manner; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; PST2 has a paralog, RFS1, that arose from the whole genome duplication biological_process molecular_function mitochondrion|membrane raft|plasma membrane|cytoplasm
YLR431C YLR431C ATG23 hom Verified 1.0923794066999 0.137333185385281 no 633 0.151029871218172 568 NA FT PROTEIN LOCALIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS Peripheral membrane protein required for the cytoplasm-to-vacuole targeting (Cvt) pathway and efficient macroautophagy; cycles between the phagophore assembly site (PAS) and non-PAS locations; forms a complex with Atg9p and Atg27p protein localization to pre-autophagosomal structure|positive regulation of macroautophagy|CVT pathway molecular_function pre-autophagosomal structure|extrinsic to membrane
YDL197C YDL197C ASF2 hom Verified 1.09234689788414 0.137340327037447 no 634 0.110849347146655 395 NA FT GENE SILENCING NUCLEUS|CHROMOSOME Anti-silencing protein that causes derepression of silent loci when overexpressed chromatin silencing at silent mating-type cassette molecular_function nuclear chromosome, telomeric region|nucleus
YJR119C YJR119C JHD2 hom Verified 1.08917659699738 0.138038008562459 no 635 0.112417779116697 411 NA FT CHROMATIN ORGANIZATION|OXIDATION-REDUCTION PROCESS NUCLEUS JmjC domain family histone demethylase specific for H3-K4 (histone H3 Lys4); removes methyl groups specifically added by Set1p methyltransferase; protein levels regulated by Not4p (E3 ubiquitin ligase) polyubiquitin-mediated degradation histone demethylation histone demethylase activity (H3-K4 specific) nucleus|cytoplasm
YKR014C YKR014C YPT52 hom Verified 1.08839570027799 0.138210229251876 no 636 0.146410017015597 543 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING|VACUOLAR TRANSPORT ENDOPLASMIC RETICULUM|PLASMA MEMBRANE Rab family GTPase, similar to Ypt51p and Ypt53p and to mammalian rab5; required for vacuolar protein sorting and endocytosis; protein abundance increases in response to DNA replication stress endocytosis|protein targeting to vacuole GTPase activity late endosome
YPR078C_p YPR078C YPR078C hom Uncharacterized 1.08739187396777 0.138431830439896 no 637 0.117593607029634 469 NA Putative protein of unknown function; possible role in DNA metabolism and/or in genome stability; expression is heat-inducible biological_process molecular_function cellular_component
YCR005C YCR005C CIT2 hom Verified 1.08677906462198 0.13856723105863 no 638 0.128890121446407 414 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION Citrate synthase; catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate, peroxisomal isozyme involved in glyoxylate cycle; expression is controlled by Rtg1p and Rtg2p transcription factors; CIT2 has a paralog, CIT1, that arose from the whole genome duplication glyoxylate cycle|glutamate biosynthetic process|citrate metabolic process citrate (Si)-synthase activity mitochondrion|peroxisome
YCL063W YCL063W VAC17 hom Verified 1.08652011796958 0.138624472599017 no 639 0.144210252086202 548 NA Phosphoprotein involved in vacuole inheritance; degraded in late M phase of the cell cycle; acts as a vacuole-specific receptor for myosin Myo2p vacuole inheritance protein anchor fungal-type vacuole membrane
YGR244C YGR244C LSC2 hom Verified 1.08416763721171 0.139145238978617 no 640 0.140015693052258 509 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION Beta subunit of succinyl-CoA ligase, which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate tricarboxylic acid cycle|succinyl-CoA metabolic process succinate-CoA ligase (ADP-forming) activity mitochondrion
YGR021W_p YGR021W YGR021W hom Uncharacterized 1.08395184063156 0.139193076242443 no 641 0.149441557674694 514 NA FT MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process molecular_function mitochondrion
YDR482C YDR482C CWC21 hom Verified 1.08226784888471 0.139566763901849 no 642 0.157426062374581 572 NA FT RNA PROCESSING NUCLEUS Protein involved in RNA splicing by the spliceosome; component of a complex containing Cef1p; interacts genetically with ISY1 and BUD13; may bind RNA; has similarity to S. pombe Cwf21p mRNA splicing, via spliceosome molecular_function U2-type spliceosomal complex
YLR265C YLR265C NEJ1 hom Verified 1.08196455905408 0.139634138132689 no 643 0.127398382918876 424 NA FT RESPONSE TO DNA DAMAGE ENDOMEMBRANE SYSTEM|NUCLEUS Protein involved in regulation of nonhomologous end joining; interacts with DNA ligase IV components Dnl4p and Lif1p; repressed by MAT heterozygosity; regulates cellular distribution of Lif1p double-strand break repair via nonhomologous end joining|double-strand break repair via single-strand annealing DNA end binding DNA ligase IV complex|nucleus
YKL164C YKL164C PIR1 hom Verified 1.08183463321726 0.139663007235044 no 644 0.130306822420427 435 NA FT PROTEIN LOCALIZATION|CELL WALL ORG/BIOGENESIS O-glycosylated protein required for cell wall stability; attached to the cell wall via beta-1,3-glucan; mediates mitochondrial translocation of Apn1p; expression regulated by the cell integrity pathway and by Swi5p during the cell cycle; PIR1 has a paralog, YJL160C, that arose from the whole genome duplication intracellular protein transport|fungal-type cell wall organization structural constituent of cell wall fungal-type cell wall
YBL003C YBL003C HTA2 hom Verified 1.08132989504201 0.139775196936502 no 645 0.127318005426774 444 NA FT CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME Histone H2A, core histone protein required for chromatin assembly and chromosome function; one of two nearly identical (see also HTA1) subtypes; DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p DNA repair|chromatin assembly or disassembly DNA binding replication fork protection complex|nuclear nucleosome
YPL026C YPL026C SKS1 hom Verified 1.08100925001156 0.139846499503701 no 646 0.0860678056170472 337 NA FT TRANSCRIPTION FROM RNA POL II|PROTEIN PHOSPHORYLATION NUCLEUS Putative serine/threonine protein kinase; involved in the adaptation to low concentrations of glucose independent of the SNF3 regulated pathway glucose transport|protein phosphorylation|response to glucose stimulus|positive regulation of transcription from RNA polymerase II promoter protein serine/threonine kinase activity|protein kinase activity nucleus|cytoplasm
YGR008C YGR008C STF2 hom Verified 1.08093716479409 0.139862532661245 no 647 0.13818927757684 460 NA FT MITOCHONDRION Protein involved in resistance to dessication stress; Stf2p exhibits antioxidant properties, and its overexpression prevents ROS accumulation and apoptosis; binds to the F0 sector of mitochondrial F1F0 ATPase in vitro and is proposed to modulate the inhibitory action of Inh1p and Stf1p; protein abundance increases in response to DNA replication stress cellular response to desiccation molecular_function cytoplasm
YPL156C YPL156C PRM4 hom Verified 1.08014287199532 0.140039281593361 no 648 0.112618902669227 447 NA Pheromone-regulated protein proposed to be involved in mating; predicted to have 1 transmembrane segment; transcriptionally regulated by Ste12p during mating and by Cat8p during the diauxic shift biological_process molecular_function integral to membrane
YOR298W YOR298W MUM3 hom Verified 1.07530797449898 0.141118433551209 no 649 0.143949819805274 468 NA FT LIPID METABOLISM|CELL WALL ORG/BIOGENESIS Protein of unknown function involved in the organization of the outer spore wall layers; has similarity to the tafazzins superfamily of acyltransferases ascospore wall assembly|phospholipid biosynthetic process transferase activity, transferring acyl groups cellular_component
YGL015C_p YGL015C YGL015C hom Uncharacterized 1.0749335044451 0.141202250144818 no 650 0.122586132280769 424 NA Putative protein of unknown function; null mutants accumulate cargo in the Golgi biological_process molecular_function cellular_component
YPR156C YPR156C TPO3 hom Verified 1.07421027453912 0.141364224214355 no 651 0.122326803068329 480 NA FT PLASMA MEMBRANE Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; specific for spermine; localizes to the plasma membrane; TPO3 has a paralog, TPO2, that arose from the whole genome duplication spermine transport spermine transmembrane transporter activity fungal-type vacuole membrane|integral to membrane|plasma membrane
YHR167W YHR167W THP2 hom Verified 1.07171230392538 0.141924636349535 no 652 0.156035315738504 582 NA FT TRANSCRIPTION FROM RNA POL II|RNA LOCALIZATION NUCLEUS Subunit of the THO complex, which connects transcription elongation and mitotic recombination, and of the TREX complex, which is recruited to activated genes and couples transcription to mRNA export; involved in telomere maintenance mRNA export from nucleus|transcription elongation from RNA polymerase II promoter|DNA recombination nucleic acid binding THO complex part of transcription export complex|nucleoplasmic THO complex
YOL018C YOL018C TLG2 hom Verified 1.0712166179207 0.142036020617233 no 653 0.268284989539615 920 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT GOLGI APPARATUS Syntaxin-like t-SNARE that forms a complex with Tlg1p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds Vps45p, which prevents Tlg2p degradation and also facilitates t-SNARE complex formation; homologous to mammalian SNARE protein syntaxin 16 (Sx16) inositolphosphoceramide metabolic process|Golgi to vacuole transport|endocytosis|mannosyl-inositol phosphorylceramide metabolic process|protein exit from endoplasmic reticulum|vesicle fusion|CVT pathway SNAP receptor activity SNARE complex|trans-Golgi network|integral to endosome membrane
YMR275C YMR275C BUL1 hom Verified 1.06904522840731 0.142524644955248 no 654 0.156670470443874 574 NA FT MITOCHONDRION ORGANIZATION PLASMA MEMBRANE UBIQUITIN LIGASE COMPLEX Ubiquitin-binding component of the Rsp5p E3-ubiquitin ligase complex; disruption causes temperature-sensitive growth, overexpression causes missorting of amino acid permeases; BUL1 has a paralog, BUL2, that arose from the whole genome duplication mitochondrion inheritance|protein monoubiquitination|protein polyubiquitination ubiquitin-ubiquitin ligase activity ubiquitin ligase complex|plasma membrane
YLR111W_d YLR111W YLR111W hom Dubious 1.06836868378346 0.142677118727919 no 655 0.164905120306337 684 NA FF Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YER079W_p YER079W YER079W hom Uncharacterized 1.0675130023224 0.142870122711866 no 656 0.133591279514319 456 NA FT NUCLEUS Putative protein of unknown function biological_process molecular_function nucleus|cytoplasm
YEL006W YEL006W YEA6 hom Verified 1.06520015704103 0.143392681290067 no 657 0.147003330105007 530 NA FT MITOCHONDRION Putative mitochondrial NAD+ transporter, member of the mitochondrial carrier subfamily (see also YIA6); has putative human ortholog transport|NAD transmembrane transport transporter activity|NAD transporter activity mitochondrion|integral to membrane|mitochondrial inner membrane
YLR027C YLR027C AAT2 hom Verified 1.06416449642977 0.143627093704329 no 658 0.19401665767642 636 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Cytosolic aspartate aminotransferase, involved in nitrogen metabolism; localizes to peroxisomes in oleate-grown cells aspartate biosynthetic process L-aspartate:2-oxoglutarate aminotransferase activity cytosol|peroxisome
YBR242W_p YBR242W YBR242W hom Uncharacterized 1.05944495035493 0.14469859374527 no 659 0.186327745370078 613 NA FT NUCLEUS Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YBR242W is not an essential gene biological_process molecular_function nucleus|cytoplasm
YMR119W YMR119W ASI1 hom Verified 1.05926741013124 0.144739006316442 no 660 0.188944590522681 623 NA FT PROTEOLYSIS ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM Putative integral membrane E3 ubiquitin ligase; acts with Asi2p and Asi3p to ensure the fidelity of SPS-sensor signalling by maintaining the dormant repressed state of gene expression in the absence of inducing signals; ASI1 has a paralog, ASI3, that arose from the whole genome duplication ubiquitin-dependent protein catabolic process ubiquitin-protein ligase activity integral to membrane|nuclear inner membrane|endoplasmic reticulum membrane
YMR103C_d YMR103C YMR103C hom Dubious 1.05903682178591 0.144791505306407 no 661 0.1460058641407 487 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YLR441C YLR441C RPS1A hom Verified 1.05788635481759 0.14505362839699 no 662 0.16812146212959 554 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Ribosomal protein 10 (rp10) of the small (40S) subunit; homologous to mammalian ribosomal protein S3A, no bacterial homolog; RPS1A has a paralog, RPS1B, that arose from the whole genome duplication cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) structural constituent of ribosome cytosolic small ribosomal subunit|90S preribosome
YDR363W YDR363W ESC2 hom Verified 1.05776172371088 0.145082043586542 no 663 0.165796958455223 571 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION|GENE SILENCING NUCLEUS Sumo-like domain protein; prevents accumulation of toxic intermediates during replication-associated recombinational repair; roles in silencing, lifespan, chromatid cohesion and the intra-S-phase DNA damage checkpoint; RENi family member intra-S DNA damage checkpoint|double-strand break repair via homologous recombination|chromatin silencing at silent mating-type cassette|mitotic sister chromatid cohesion molecular_function nucleus
YLR328W YLR328W NMA1 hom Verified 1.05701264385845 0.145252908494313 no 664 0.177856218359641 506 NA FT NUCLEOTIDE METABOLISM|COFACTOR METABOLISM NUCLEUS Nicotinic acid mononucleotide adenylyltransferase; catalyzes the transfer of the adenylyl moiety of ATP to nicotinamide mononucleotide to form NAD; involved in pathways of NAD biosynthesis, including the de novo, NAD(+) salvage, and nicotinamide riboside salvage pathways; NMA1 has a paralog, NMA2, that arose from the whole genome duplication NAD biosynthetic process nicotinamide-nucleotide adenylyltransferase activity nucleus|cytoplasm
YDL080C YDL080C THI3 hom Verified 1.05667871703993 0.145329120723202 no 665 0.131350216195753 460 NA FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS Probable alpha-ketoisocaproate decarboxylase, may have a role in catabolism of amino acids to long-chain and complex alcohols; required for expression of enzymes involved in thiamine biosynthesis regulation of thiamine biosynthetic process|branched-chain amino acid catabolic process to alcohol via Ehrlich pathway|positive regulation of transcription from RNA polymerase II promoter|leucine catabolic process carboxy-lyase activity cytosol|nucleus
YLR059C YLR059C REX2 hom Verified 1.05614325224259 0.145451386177239 no 666 0.155964679864917 521 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|MITOCHONDRION ORGANIZATION MITOCHONDRION 3'-5' RNA exonuclease; involved in 3'-end processing of U4 and U5 snRNAs, 5S and 5.8S rRNAs, and RNase P and RNase MRP RNA; localized to mitochondria and null suppresses escape of mtDNA to nucleus in yme1 yme2 mutants; RNase D exonuclease U5 snRNA 3'-end processing|U4 snRNA 3'-end processing|mitochondrial genome maintenance|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 3'-5'-exoribonuclease activity|3'-5' exonuclease activity mitochondrion
YDR200C YDR200C VPS64 hom Verified 1.053688163888 0.146012854832166 no 667 0.1871905800903 633 NA FT PROTEIN LOCALIZATION|CELL CYCLE|SIGNALING|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Protein required for cytoplasm to vacuole targeting of proteins; forms a complex with Far3p and Far7p to Far11p involved in recovery from pheromone-induced cell cycle arrest; mutant has increased aneuploidy tolerance re-entry into mitotic cell cycle after pheromone arrest|protein targeting to vacuole molecular_function endoplasmic reticulum membrane|cytoplasm
YER170W YER170W ADK2 hom Verified 1.05280415930601 0.146215379152098 no 668 0.148922950151644 551 NA FT NUCLEOTIDE METABOLISM MITOCHONDRION Mitochondrial adenylate kinase, catalyzes the reversible synthesis of GTP and AMP from GDP and ADP; may serve as a back-up for synthesizing GTP or ADP depending on metabolic conditions; 3' sequence of ADK2 varies with strain background nucleotide metabolic process nucleoside triphosphate adenylate kinase activity|adenylate kinase activity mitochondrion|mitochondrial inner membrane
YML020W_p YML020W YML020W hom Uncharacterized 1.0522438860142 0.146343834678301 no 669 0.144921003694132 527 NA Putative protein of unknown function biological_process molecular_function cellular_component
YGR177C YGR177C ATF2 hom Verified 1.05161754076822 0.146487528397711 no 670 0.127496148460837 445 NA FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Alcohol acetyltransferase, may play a role in steroid detoxification; forms volatile esters during fermentation, which is important for brewing and winemaking steroid metabolic process|response to toxin|Unknown|sterol acetylation alcohol O-acetyltransferase activity integral to endoplasmic reticulum membrane|endoplasmic reticulum|cytoplasm
YGR214W YGR214W RPS0A hom Verified 1.05056816971334 0.146728483265356 no 671 0.144130212397419 507 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION RIBOSOME Ribosomal 40S subunit protein S0A; required for maturation of 18S rRNA along with Rps0Bp; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2; RPS0A has a paralog, RPS0B, that arose from the whole genome duplication; cytoplasmic translation|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|rRNA export from nucleus|ribosomal small subunit assembly|endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) structural constituent of ribosome cytosolic small ribosomal subunit|90S preribosome
YER053C YER053C PIC2 hom Verified 1.05017489996949 0.146818853688333 no 672 0.103566416786632 355 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; functionally redundant with Mir1p but less abundant than Mir1p under normal conditions; expression is induced at high temperature phosphate ion transport|transmembrane transport inorganic phosphate transmembrane transporter activity mitochondrion|integral to membrane
YGR224W YGR224W AZR1 hom Verified 1.04987377717313 0.146888074672376 no 673 0.128223283212825 501 NA FT PLASMA MEMBRANE Plasma membrane transporter of the major facilitator superfamily, involved in resistance to azole drugs such as ketoconazole and fluconazole azole transport azole transporter activity integral to membrane|plasma membrane
YBR213W YBR213W MET8 hom Verified 1.04665579928025 0.147629178277888 no 674 0.165577429478297 558 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM Bifunctional dehydrogenase and ferrochelatase, involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis siroheme biosynthetic process|sulfate assimilation precorrin-2 dehydrogenase activity|ferrochelatase activity cellular_component
YDL047W YDL047W SIT4 hom Verified 1.04473057692488 0.148073754317802 no 675 0.150366050431641 549 NA FT CELL CYCLE|RNA PROCESSING|SIGNALING|RESPONSE TO DNA DAMAGE|CELL WALL ORG/BIOGENESIS|CELL DIVISION|CYTOSKELETON ORGANIZATION|RESPONSE TO OXIDATIVE STRESS NUCLEUS Type 2A-related serine-threonine phosphatase that functions in the G1/S transition of the mitotic cycle; cytoplasmic and nuclear protein that modulates functions mediated by Pkc1p including cell wall and actin cytoskeleton organization intracellular protein kinase cascade|replicative cell aging|G1/S transition of mitotic cell cycle|actin cytoskeleton organization|DNA repair|cellular response to oxidative stress|fungal-type cell wall organization|TOR signaling cascade|dephosphorylation|tRNA wobble uridine modification protein serine/threonine phosphatase activity nucleus|cytoplasm
YPL031C YPL031C PHO85 hom Verified 1.0421870193409 0.148662490021578 no 676 0.185383355836848 607 NA FT PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|CELL CYCLE|SIGNALING|RESPONSE TO DNA DAMAGE|CELL WALL ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS|GEN. OF PRECURSOR METABOLITES A NUCLEUS Cyclin-dependent kinase, with ten cyclin partners; involved in regulating the cellular response to nutrient levels and environmental conditions and progression through the cell cycle regulation of transcription involved in G1/S phase of mitotic cell cycle|negative regulation of calcium-mediated signaling|regulation of protein stability|regulation of protein localization|protein phosphorylation|response to DNA damage stimulus|negative regulation of phosphate metabolic process|fungal-type cell wall organization|regulation of establishment or maintenance of cell polarity|negative regulation of glycogen biosynthetic process|negative regulation of transcription from RNA polymerase II promoter|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of macroautophagy|negative regulation of macroautophagy protein kinase activity|cyclin-dependent protein kinase activity cyclin-dependent protein kinase holoenzyme complex|nucleus
YGL076C YGL076C RPL7A hom Verified 1.0398218773082 0.14921133153131 no 677 0.140274881292226 482 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L7A; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2); homologous to mammalian ribosomal protein L7 and bacterial L30; RPL7A has a paralog, RPL7B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit|cytoplasm
YOL101C YOL101C IZH4 hom Verified 1.03952207369619 0.149280998771275 no 678 0.158426186326915 559 NA FT LIPID METABOLISM|ION HOMEOSTASIS|ION HOMEOSTASIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Membrane protein involved in zinc ion homeostasis; member of the four-protein IZH family; expression induced by fatty acids and altered zinc levels; deletion reduces sensitivity to excess zinc; possible role in sterol metabolism; protein increases in abundance and relocalizes from nucleus to ER upon DNA replication stress cellular zinc ion homeostasis|cellular lipid metabolic process metal ion binding integral to membrane|membrane
YGR263C YGR263C SAY1 hom Verified 1.03946662516729 0.14929388607216 no 679 0.158368714870708 518 NA FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Sterol deacetylase; component of the sterol acetylation/deacetylation cycle along with Atf2p; integral membrane protein with active site in the ER lumen; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum response to toxin|sterol metabolic process|sterol deacetylation steryl deacetylase activity integral to membrane|endoplasmic reticulum|endoplasmic reticulum lumen
YER132C YER132C PMD1 hom Verified 1.03808273135057 0.149615770148133 no 680 0.155800189443202 551 NA FT CELL CYCLE Protein with an N-terminal kelch-like domain, putative negative regulator of early meiotic gene expression; required, with Mds3p, for growth under alkaline conditions sporulation resulting in formation of a cellular spore molecular_function cytoplasm
YGR077C YGR077C PEX8 hom Verified 1.03757561775598 0.14973383709392 no 681 0.0738468589768346 315 NA FT PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p protein targeting to peroxisome|peroxisome organization peroxisome targeting sequence binding peroxisomal matrix|peroxisomal membrane|extrinsic to intraperoxisomal membrane
YKL027W YKL027W YKL027W hom Verified 1.03595969550271 0.150110473022945 no 682 0.153853785722964 551 NA FT MITOCHONDRION Protein of unknown function, localized to the mitochondrial outer membrane biological_process molecular_function mitochondrial outer membrane|mitochondrion
YMR023C YMR023C MSS1 hom Verified 1.03512257622125 0.150305835232002 no 683 0.116515154651076 432 NA FT RNA PROCESSING|SIGNALING|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial protein, forms a heterodimer complex with Mto1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; similar to human GTPBP3 mitochondrial tRNA wobble uridine modification|Unknown GTP binding mitochondrion|mitochondrial inner membrane
YNL024C_p YNL024C YNL024C hom Uncharacterized 1.03413586692769 0.150536325379445 no 684 0.151844746884703 558 NA Putative methyltransferase; has seven beta-strand methyltransferase motif; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; despite similarity to methyltransferases, null mutant does not display alterations in lysine methylation pattern biological_process S-adenosylmethionine-dependent methyltransferase activity cytoplasm
YBR035C YBR035C PDX3 hom Verified 1.03407191510907 0.150551272310585 no 685 0.141993265122807 558 NA FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM Pyridoxine (pyridoxamine) phosphate oxidase, has homologs in E. coli and Myxococcus xanthus; transcription is under the general control of nitrogen metabolism fatty acid metabolic process pyridoxamine-phosphate oxidase activity cellular_component
YLR077W YLR077W FMP25 hom Verified 1.0335978614572 0.150662099782407 no 686 0.156597702137964 549 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial inner membrane protein required for an early step in assembly of respiratory complex III (cytochrome bc1 complex); mRNA is targeted to mitochondria mitochondrial respiratory chain complex III assembly molecular_function mitochondrion|integral to mitochondrial inner membrane
YHR059W YHR059W FYV4 hom Verified 1.03350179959978 0.150684564392199 no 687 0.139212494741599 520 NA FT MITOCHONDRION Protein of unknown function, required for survival upon exposure to K1 killer toxin biological_process molecular_function mitochondrion
YDL238C YDL238C GUD1 hom Verified 1.03333356170801 0.150723913150368 no 688 0.151687159348191 532 NA Guanine deaminase, a catabolic enzyme of the guanine salvage pathway producing xanthine and ammonia from guanine; activity is low in exponentially-growing cultures but expression is increased in post-diauxic and stationary-phase cultures guanine metabolic process guanine deaminase activity|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides cytoplasm
YPR111W YPR111W DBF20 hom Verified 1.03218730427718 0.150992190657928 no 689 0.122189411394225 442 NA FT CELL CYCLE|CELL DIVISION|PROTEIN PHOSPHORYLATION SITE OF POLARIZED GROWTH|CYTOSKELETON Ser/Thr kinase involved in late nuclear division, one of the mitotic exit network (MEN) proteins; necessary for the execution of cytokinesis; also plays a role in regulating the stability of SWI5 and CLB2 mRNAs cytokinesis after mitosis|protein phosphorylation|barrier septum assembly involved in cell cycle cytokinesis|regulation of mRNA catabolic process|exit from mitosis protein serine/threonine kinase activity spindle pole body|cellular bud neck|cytoplasm
YKR100C YKR100C SKG1 hom Verified 1.03194747822888 0.151048361274238 no 690 0.160587708916664 581 NA FT CELL WALL ORG/BIOGENESIS SITE OF POLARIZED GROWTH|PLASMA MEMBRANE Transmembrane protein with a role in cell wall polymer composition; localizes on the inner surface of the plasma membrane at the bud and in the daughter cell fungal-type cell wall organization molecular_function incipient cellular bud site|cellular bud|cellular bud tip
YDR074W YDR074W TPS2 hom Verified 1.03134876885896 0.151188648064701 no 691 0.232940530622985 785 NA FT CARBOHYDRATE METABOLISM MITOCHONDRION Phosphatase subunit of the trehalose-6-P synthase/phosphatase complex; involved in synthesis of the storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway; protein abundance increases in response to DNA replication stress trehalose biosynthetic process|response to stress trehalose-phosphatase activity mitochondrion|alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)
YJR024C YJR024C MDE1 hom Verified 1.02830703271642 0.151902711974903 no 692 0.137970627317557 465 NA FT KETONE METABOLISM|AMINO ACID METABOLISM 5'-methylthioribulose-1-phosphate dehydratase; acts in the methionine salvage pathway; potential Smt3p sumoylation substrate; expression downregulated by caspofungin and deletion mutant is caspofungin resistant L-methionine salvage from methylthioadenosine methylthioribulose 1-phosphate dehydratase activity cytoplasm
YLR085C YLR085C ARP6 hom Verified 1.02786153602396 0.152007482516624 no 693 0.199099603828199 725 NA FF|FT CHROMATIN ORGANIZATION NUCLEUS|CHROMOSOME Actin-related protein that binds nucleosomes; a component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A chromatin remodeling|histone exchange nucleosome binding Swr1 complex|cytoplasm
YKL129C YKL129C MYO3 hom Verified 1.02768197638064 0.152049724369462 no 694 0.107955627375009 371 NA FT VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS|CELL DIVISION CYTOSKELETON One of two type I myosins; localizes to actin cortical patches; deletion of MYO3 has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization bipolar cellular bud site selection|fungal-type cell wall organization|endocytosis|exocytosis|actin cortical patch localization|response to osmotic stress microfilament motor activity actin cortical patch
YIL059C_d YIL059C YIL059C hom Dubious 1.0256626837874 0.15252530477618 no 695 0.122112801047262 436 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YIL060W Unknown Unknown Unknown
YLR187W YLR187W SKG3 hom Verified 1.02527600071205 0.152616488208002 no 696 0.151081081534085 472 NA FT SITE OF POLARIZED GROWTH|PLASMA MEMBRANE Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; potential Cdc28p substrate; similar to Skg4p; relocalizes from bud neck to cytoplasm upon DNA replication stress; SKG3 has a paralog, CAF120, that arose from the whole genome duplication biological_process molecular_function cellular bud|cellular bud neck|cytoplasm
YLR107W YLR107W REX3 hom Verified 1.02482029799039 0.15272399352252 no 697 0.135969797647534 464 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS RNA exonuclease; required for maturation of the RNA component of RNase MRP; functions redundantly with Rnh70p and Rex2p in processing of U5 snRNA and RNase P RNA; member of RNase D family of exonucleases U5 snRNA 3'-end processing|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|ncRNA 3'-end processing 3'-5'-exoribonuclease activity|3'-5' exonuclease activity nucleus|cytoplasm
YGL240W YGL240W DOC1 hom Verified 1.02476350997247 0.152737393963225 no 698 0.162594401115569 596 NA FT CELL CYCLE|CHROMATIN ORGANIZATION|CELL DIVISION|PROTEOLYSIS NUCLEUS|MITOCHONDRION UBIQUITIN LIGASE COMPLEX Processivity factor required for the ubiquitination activity of the anaphase promoting complex (APC), mediates the activity of the APC by contributing to substrate recognition; involved in cyclin proteolysis; contains a conserved DOC1 homology domain activation of mitotic anaphase-promoting complex activity|chromatin assembly|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cyclin catabolic process enzyme regulator activity|mitotic anaphase-promoting complex activity mitochondrion|anaphase-promoting complex
YGR012W YGR012W YGR012W hom Verified 1.02251069293812 0.153269627167143 no 699 0.1378824032311 458 NA FT KETONE METABOLISM|AMINO ACID METABOLISM MITOCHONDRION Putative cysteine synthase, localized to the mitochondrial outer membrane cysteine biosynthetic process cysteine synthase activity mitochondrial outer membrane|mitochondrion
YMR279C YMR279C YMR279C hom Verified 1.0221860906604 0.153346416368424 no 700 0.172651036576815 585 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS Putative boron transporter involved in boron efflux and resistance; overexpression mutant but not null mutant displays boron tolerance phenotype; identified as a heat-induced gene in a high-throughout screen; YMR279C is not an essential gene; YMR279C has a paralog, ATR1, that arose from the whole genome duplication borate transmembrane transport borate efflux transmembrane transporter activity integral to membrane
YBR222C YBR222C PCS60 hom Verified 1.02176086707883 0.15344704750075 no 701 0.120460508155726 452 NA Peroxisomal protein that binds AMP and mRNA, localizes to both the peroxisomal peripheral membrane and matrix, expression is highly inducible by oleic acid, similar to E. coli long chain acyl-CoA synthetase biological_process mRNA binding|AMP binding integral to membrane|peroxisomal matrix|peroxisomal membrane|cytoplasm
YDR099W YDR099W BMH2 hom Verified 1.0202408011283 0.153807135743682 no 702 0.165043418517027 528 NA FT CELL CYCLE|SIGNALING|RESPONSE TO DNA DAMAGE|CELL WALL ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY NUCLEUS 14-3-3 protein, minor isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress glycogen metabolic process|ascospore formation|Ras protein signal transduction|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|DNA damage checkpoint|DNA replication initiation|signal transduction involved in filamentous growth|pseudohyphal growth|fungal-type cell wall chitin biosynthetic process|pre-replicative complex assembly DNA replication origin binding|phosphoserine binding nucleus|plasma membrane
YGR096W YGR096W TPC1 hom Verified 1.01972629092155 0.153929144601045 no 703 0.177489183394385 548 NA FT MITOCHONDRION Mitochondrial membrane transporter that mediates uptake of the essential cofactor thiamine pyrophosphate (ThPP) into mitochondria; expression appears to be regulated by carbon source; member of the mitochondrial carrier family thiamine pyrophosphate transport thiamine transmembrane transporter activity integral to membrane|integral to mitochondrial inner membrane
YGR165W YGR165W MRPS35 hom Verified 1.01655558442683 0.154682446223542 no 704 0.197528355561636 690 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the small subunit; null mutant does not grow on glycerol, is sensitive to 2,4-dichlorophenol, and accumulates large lipid droplets mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial small ribosomal subunit
YPR189W YPR189W SKI3 hom Verified 1.01617856977071 0.154772179754517 no 705 0.134640052850713 512 NA FT NUCLEUS Ski complex component and TPR protein, mediates 3'-5' RNA degradation by the cytoplasmic exosome; null mutants have superkiller phenotype of increased viral dsRNAs and are synthetic lethal with mutations in 5'-3' mRNA decay nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'|nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay|nuclear-transcribed mRNA catabolic process, non-stop decay molecular_function Ski complex
YPL186C YPL186C UIP4 hom Verified 1.01570094595099 0.154885908718182 no 706 0.1840858860249 606 NA FT ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|MITOCHONDRION Protein that interacts with Ulp1p, a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates; detected in a phosphorylated state in the mitochondrial outer membrane; also detected in ER and nuclear envelope biological_process molecular_function mitochondrial outer membrane|nuclear envelope|endoplasmic reticulum
YOL085C_d YOL085C YOL085C hom Dubious 1.01183625323087 0.155808176439823 no 707 0.15444957843971 510 NA Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOL085W-A Unknown Unknown Unknown
YOR331C_d YOR331C YOR331C hom Dubious 1.01125106292322 0.155948140865438 no 708 0.203224802107959 666 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene VMA4/YOR332W Unknown Unknown Unknown
YPL201C YPL201C YIG1 hom Verified 1.01080977877633 0.15605374095327 no 709 0.158880281406857 587 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY NUCLEUS Protein that interacts with glycerol 3-phosphatase and plays a role in anaerobic glycerol production; localizes to the nucleus and cytosol glycerol biosynthetic process molecular_function cytosol|nucleus
YDL078C YDL078C MDH3 hom Verified 1.01056954502465 0.156111249126749 no 710 0.125022790267371 414 NA FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM Peroxisomal malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the glyoxylate cycle glyoxylate cycle|fatty acid beta-oxidation|malate metabolic process|NADH regeneration L-malate dehydrogenase activity|mRNA binding peroxisomal matrix|peroxisome
YCR020C YCR020C PET18 hom Verified 1.00905659405942 0.156473746618609 no 711 0.152709339895262 539 NA Protein of unknown function, has weak similarity to proteins involved in thiamin metabolism; expression is induced in the absence of thiamin thiamine metabolic process molecular_function cytosol
YIL107C YIL107C PFK26 hom Verified 1.00608235731119 0.157187977360523 no 712 0.167859348140382 595 NA FT CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY 6-phosphofructo-2-kinase, inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate; has negligible fructose-2,6-bisphosphatase activity; transcriptional regulation involves protein kinase A regulation of glycolysis|fructose 2,6-bisphosphate metabolic process 6-phosphofructo-2-kinase activity cytoplasm
YDR179C YDR179C CSN9 hom Verified 1.00584419687507 0.157245261567013 no 713 0.152741247645583 498 NA FT SIGNALING NUCLEUS Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion|cullin deneddylation molecular_function signalosome
YOL048C YOL048C RRT8 hom Verified 1.00330561309006 0.157856714351149 no 714 0.151665496837445 528 NA Protein of unknown function; identified in a screen for mutants with increased levels of rDNA transcription; green fluorescent protein (GFP)-fusion protein localizes to lipid particles; protein abundance increases in response to DNA replication stress biological_process molecular_function integral to membrane|lipid particle
YGL053W YGL053W PRM8 hom Verified 1.00178188266748 0.158224474632526 no 715 0.145280549644625 500 NA FT VESICLE-MEDIATED TRANSPORT ENDOPLASMIC RETICULUM|PLASMA MEMBRANE Pheromone-regulated protein with 2 predicted transmembrane segments and an FF sequence, a motif involved in COPII binding; forms a complex with Prp9p in the ER; member of DUP240 gene family biological_process molecular_function integral to membrane|endoplasmic reticulum|plasma membrane
YPL192C YPL192C PRM3 hom Verified 1.00062115692092 0.158504998821758 no 716 0.137804118653088 524 NA FT MEMBRANE ORGANIZATION ENDOMEMBRANE SYSTEM|NUCLEUS|CYTOSKELETON Pheromone-regulated protein required for nuclear envelope fusion during karyogamy; localizes to the outer face of the nuclear membrane; interacts with Kar5p at the spindle pole body karyogamy involved in conjugation with cellular fusion|nuclear membrane fusion involved in karyogamy molecular_function nuclear envelope|spindle pole body|extrinsic to nuclear outer membrane
YOL037C_d YOL037C YOL037C hom Dubious 0.999945214760073 0.158668510718783 no 717 0.170210588016545 586 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOL036W Unknown Unknown Unknown
YLR315W YLR315W NKP2 hom Verified 0.99954679025795 0.15876494227138 no 718 0.20057564413034 641 NA FT CELL CYCLE|CELL DIVISION NUCLEUS|CHROMOSOME|CYTOSKELETON KINETOCHORE Central kinetochore protein and subunit of the Ctf19 complex; mutants have elevated rates of chromosome loss; orthologous to fission yeast kinetochore protein cnl2 biological_process molecular_function spindle pole body|kinetochore
YFL013C YFL013C IES1 hom Verified 0.999365797581867 0.158808761011911 no 719 0.190735842267056 631 NA FT CHROMATIN ORGANIZATION NUCLEUS|CHROMOSOME Subunit of the INO80 chromatin remodeling complex nucleosome mobilization molecular_function nucleus|Ino80 complex
YGR102C YGR102C GTF1 hom Verified 0.999033037717219 0.158889343618843 no 720 0.160310027582612 578 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION MITOCHONDRION Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is salt sensitive and null mutant has growth defects; non-tagged protein is detected in purified mitochondria glutaminyl-tRNAGln biosynthesis via transamidation glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity mitochondrion|glutamyl-tRNA(Gln) amidotransferase complex
YER017C YER017C AFG3 hom Verified 0.996827537411985 0.159424114659807 no 721 0.197838583825886 675 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Component, with Yta12p, of the mitochondrial inner membrane m-AAA protease; mediates degradation of misfolded or unassembled proteins and is also required for correct assembly of mitochondrial enzyme complexes; involved in cytoplasmic mRNA translation and aging proteolysis|signal peptide processing|protein complex assembly|protein import into mitochondrial intermembrane space metallopeptidase activity|protein binding|ATPase activity mitochondrion|mitochondrial inner boundary membrane|mitochondrial inner membrane|m-AAA complex
YNL177C YNL177C MRPL22 hom Verified 0.996503668268448 0.159502742816353 no 722 0.195695861547626 673 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YLL009C YLL009C COX17 hom Verified 0.994232056736179 0.160054952402168 no 723 0.147185847068915 475 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS MITOCHONDRION Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs mitochondrial respiratory chain complex IV assembly|intracellular copper ion transport copper chaperone activity cytosol|mitochondrion|mitochondrial intermembrane space
YNR040W_p YNR040W YNR040W hom Uncharacterized 0.991790476343923 0.160649872189923 no 724 0.167667976896971 578 NA FT MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process molecular_function mitochondrion
YPL165C YPL165C SET6 hom Verified 0.991369562754973 0.160752578500299 no 725 0.14037976049858 464 NA SET domain protein of unknown function; deletion heterozygote is sensitive to compounds that target ergosterol biosynthesis, may be involved in compound availability biological_process molecular_function cellular_component
YGR276C YGR276C RNH70 hom Verified 0.991359221287703 0.16075510244125 no 726 0.157526829233253 533 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS 3'-5' exoribonuclease; required for maturation of 3' ends of 5S rRNA and tRNA-Arg3 from dicistronic transcripts U5 snRNA 3'-end processing|generation of mature 3'-end of 5S rRNA generated by RNA polymerase III|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|tRNA 3'-trailer cleavage, exonucleolytic 3'-5'-exoribonuclease activity|3'-5' exonuclease activity nucleus
YBR034C YBR034C HMT1 hom Verified 0.991275881889931 0.160775443218902 no 727 0.179505683361538 597 NA FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RNA LOCALIZATION NUCLEUS Nuclear SAM-dependent mono- and asymmetric arginine dimethylating methyltransferase that modifies hnRNPs, including Npl3p and Hrp1p, affecting their activity and nuclear export; methylates U1 snRNP protein Snp1p and ribosomal protein Rps2p; interacts genetically with genes encoding components of Rpd3(L) and this interaction is important for Rpd3 recruitment to the subtelomeric region. mRNA export from nucleus|negative regulation of DNA-dependent transcription, termination|positive regulation of transcription elongation from RNA polymerase II promoter|peptidyl-arginine methylation protein-arginine omega-N asymmetric methyltransferase activity|protein-arginine omega-N monomethyltransferase activity nucleus
YMR060C YMR060C SAM37 hom Verified 0.990394923381284 0.160990562914673 no 728 0.206803833455758 708 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Component of the Sorting and Assembly Machinery (SAM or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their outer membrane insertion; contributes to SAM complex stability mitochondrial outer membrane translocase complex assembly|protein import into mitochondrial outer membrane|phospholipid transport molecular_function mitochondrial outer membrane|mitochondrial sorting and assembly machinery complex|mitochondrion|integral to membrane
YBL047C YBL047C EDE1 hom Verified 0.988734657166977 0.161396490777436 no 729 0.110782184953304 489 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING SITE OF POLARIZED GROWTH|CYTOSKELETON Endocytic protein; involved in a network of interactions with other endocytic proteins, binds membranes in a ubiquitin-dependent manner, may also bind ubiquitinated membrane-associated proteins; interacts with Cmk2 and functions upstream of CMK2 in regulating non-apoptotic cell death endoplasmic reticulum unfolded protein response|endocytosis ubiquitin binding cellular bud neck|mating projection tip|actin cortical patch|cellular bud tip
YDL133C-A YDL133C-A RPL41B hom Verified 0.987861030687472 0.16161035643879 no 730 0.144974833299954 501 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L41B; comprises only 25 amino acids; rpl41a rpl41b double null mutant is viable; homologous to mammalian ribosomal protein L41, no bacterial homolog; RPL41B has a paralog, RPL41A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YPL018W YPL018W CTF19 hom Verified 0.987510197841636 0.161696293047609 no 731 0.182686818458808 630 NA FT PROTEIN LOCALIZATION|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME KINETOCHORE Outer kinetochore protein, needed for accurate chromosome segregation; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) that functions as a platform for kinetochore assembly; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-P and fission yeast fta2 attachment of spindle microtubules to kinetochore|chromosome segregation|establishment of mitotic sister chromatid cohesion molecular_function COMA complex|condensed nuclear chromosome kinetochore|nucleus
YKL061W_p YKL061W BLI1 hom Uncharacterized 0.9872006575784 0.161772139753172 no 732 0.14806122352928 497 NA Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to the endosome biological_process molecular_function endosome
YIR038C YIR038C GTT1 hom Verified 0.985334505112021 0.1622298945568 no 733 0.165137974659076 590 NA FT KETONE METABOLISM|AMINO ACID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION ER associated glutathione S-transferase capable of homodimerization; expression induced during the diauxic shift and throughout stationary phase; functional overlap with Gtt2p, Grx1p, and Grx2p glutathione metabolic process glutathione transferase activity|glutathione peroxidase activity mitochondrial outer membrane|mitochondrion|endoplasmic reticulum|plasma membrane
YMR267W YMR267W PPA2 hom Verified 0.985165816027762 0.162271314389205 no 734 0.19145096189495 686 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Mitochondrial inorganic pyrophosphatase, required for mitochondrial function and possibly involved in energy generation from inorganic pyrophosphate aerobic respiration inorganic diphosphatase activity mitochondrion
YKL176C YKL176C LST4 hom Verified 0.98427919 0.162489129271996 no 735 0.188701983300404 651 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM Protein possibly involved in a post-Golgi secretory pathway; required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface intracellular protein transport|vesicle-mediated transport|protein transport|Golgi to plasma membrane transport protein transporter activity vesicle coat
YKL062W YKL062W MSN4 hom Verified 0.983674059246534 0.162637899202721 no 736 0.157482673877974 531 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO NUTRIENT LEVELS|RESPONSE TO OXIDATIVE STRESS NUCLEUS Transcriptional activator; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression; MSN4 has a paralog, MSN2, that arose from the whole genome duplication positive regulation of transcription from RNA polymerase II promoter in response to heat stress|positive regulation of transcription from RNA polymerase II promoter in response to a hypotonic environment|positive regulation of transcription from RNA polymerase II promoter in response to alkalinity|positive regulation of transcription from RNA polymerase II promoter in response to amino acid starvation|positive regulation of transcription from RNA polymerase II promoter in response to zinc ion starvation|positive regulation of transcription from RNA polymerase II promoter in response to acidity|chromatin remodeling|regulation of replicative cell aging by regulation of transcription from RNA polymerase II promoter in response to caloric restriction|positive regulation of transcription from RNA polymerase II promoter in response to hydrogen peroxide|positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance|positive regulation of transcription from RNA polymerase II promoter in response to increased salt|cellular response to acidity|positive regulation of transcription from RNA polymerase II promoter in response to freezing|positive regulation of transcription from RNA polymerase II promoter in response to ethanol|replicative cell aging|age-dependent response to oxidative stress involved in chronological cell aging|positive regulation of transcription from RNA polymerase II promoter in response to hydrostatic pressure|positive regulation of transcription from RNA polymerase II promoter in response to nitrosative stress|positive regulation of transcription from RNA polymerase II promoter in response to cold|positive regulation of transcription from RNA polymerase II promoter in response to glucose starvation RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity|core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding cytosol|nucleus
YJL105W YJL105W SET4 hom Verified 0.982037768258609 0.163040620984698 no 737 0.170235139423561 619 NA FT CHROMATIN ORGANIZATION Protein of unknown function, contains a SET domain; SET4 has a paralog, SET3, that arose from the whole genome duplication biological_process molecular_function cellular_component
YGR208W YGR208W SER2 hom Verified 0.981735668440525 0.163115044219518 no 738 0.150502354732364 547 NA FT KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS Phosphoserine phosphatase of the phosphoglycerate pathway, involved in serine and glycine biosynthesis, expression is regulated by the available nitrogen source L-serine biosynthetic process phosphoserine phosphatase activity nucleus|cytoplasm
YLR239C YLR239C LIP2 hom Verified 0.979394539086071 0.163692537160363 no 739 0.240836775054223 833 NA FF|FT KETONE METABOLISM|LIPID METABOLISM|COFACTOR METABOLISM MITOCHONDRION Lipoyl ligase, involved in the modification of mitochondrial enzymes by the attachment of lipoic acid groups protein lipoylation ligase activity mitochondrion
YLR244C YLR244C MAP1 hom Verified 0.97910851488668 0.163763182427076 no 740 0.180098532069895 578 NA FT PROTEOLYSIS RIBOSOME Methionine aminopeptidase, catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map2p negative regulation of gene expression|protein initiator methionine removal involved in protein maturation metalloaminopeptidase activity|mRNA binding cytosolic ribosome
YGR070W YGR070W ROM1 hom Verified 0.977989234158548 0.164039824375649 no 741 0.175711607044638 646 NA FT SIGNALING|NUCLEOTIDE METABOLISM GDP/GTP exchange protein (GEP) for Rho1p; mutations are synthetically lethal with mutations in rom2, which also encodes a GEP small GTPase mediated signal transduction|activation of Rho GTPase activity Rho guanyl-nucleotide exchange factor activity intracellular
YEL048C YEL048C TCA17 hom Verified 0.977425021018089 0.16417939042221 no 742 0.146284451670392 486 NA FT VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS GOLGI APPARATUS Subunit of TRAPPII, a multimeric GEF involved in intra-Golgi and endosome-to-Golgi transport; promotes association of TRAPPII-specific subunits with the core complex; sedlin related; human Sedlin mutations cause SEDT, a skeletal disorder early endosome to Golgi transport|protein complex assembly molecular_function TRAPP complex|Golgi apparatus|clathrin-coated vesicle
YOL095C YOL095C HMI1 hom Verified 0.976345846023439 0.16444655397385 no 743 0.185187783618212 647 NA FT RESPONSE TO DNA DAMAGE|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial inner membrane localized ATP-dependent DNA helicase, required for the maintenance of the mitochondrial genome; not required for mitochondrial transcription; has homology to E. coli helicase uvrD mitochondrial genome maintenance|mitochondrial DNA metabolic process ATP-dependent 3'-5' DNA helicase activity mitochondrion|mitochondrial matrix
YLR318W YLR318W EST2 hom Verified 0.975641125048967 0.164621168662533 no 744 0.160552970850982 601 NA FT NUCLEUS|CHROMOSOME Reverse transcriptase subunit of the telomerase holoenzyme, essential for telomerase core catalytic activity, involved in other aspects of telomerase assembly and function; mutations in human homolog are associated with aplastic anemia telomere maintenance via telomerase|replicative cell aging telomerase activity|telomeric template RNA reverse transcriptase activity|telomeric DNA binding telomerase catalytic core complex|nucleolus|nucleus|telomerase holoenzyme complex
YDR142C YDR142C PEX7 hom Verified 0.975233070706939 0.164722330648877 no 745 0.184483972035361 591 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|PEROXISOME ORGANIZATION Peroxisomal signal receptor for the N-terminal nonapeptide signal (PTS2) of peroxisomal matrix proteins; WD repeat protein; defects in human homolog cause lethal rhizomelic chondrodysplasia punctata (RCDP) protein import into peroxisome matrix, docking peroxisome matrix targeting signal-2 binding cytosol|peroxisome
YHR184W YHR184W SSP1 hom Verified 0.974053888412017 0.165014891596998 no 746 0.164529952176764 621 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL WALL ORG/BIOGENESIS|CELL DIVISION Protein involved in the control of meiotic nuclear division and coordination of meiosis with spore formation; transcription is induced midway through meiosis ascospore wall assembly|protein complex assembly molecular_function prospore membrane
YBR106W YBR106W PHO88 hom Verified 0.973471395500821 0.165159535031332 no 747 0.240939179107091 854 NA FF|FT ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION Probable membrane protein, involved in phosphate transport; pho88 pho86 double null mutant exhibits enhanced synthesis of repressible acid phosphatase at high inorganic phosphate concentrations phosphate ion transport molecular_function mitochondrion|membrane
YAL016C-B_d YAL016C-B YAL016C-B hom Dubious 0.97309420357528 0.165253242313747 no 748 0.144012082334839 531 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YDL123W YDL123W SNA4 hom Verified 0.971587657389319 0.165627862634464 no 749 0.181642789337723 547 NA Protein of unknown function, localized to the vacuolar outer membrane; predicted to be palmitoylated biological_process molecular_function fungal-type vacuole lumen|fungal-type vacuole membrane
YOL116W YOL116W MSN1 hom Verified 0.971432058508422 0.165666585380655 no 750 0.169023663575619 578 NA FT TRANSCRIPTION FROM RNA POL II|CARBOHYDRATE METABOLISM NUCLEUS Transcriptional activator; involved in regulation of invertase and glucoamylase expression, invasive growth and pseudohyphal differentiation, iron uptake, chromium accumulation, and response to osmotic stress; localizes to the nucleus; relative distribution to the nucleus increases upon DNA replication stress positive regulation of transcription from RNA polymerase II promoter in response to heat stress|positive regulation of transcription from RNA polymerase II promoter in response to methylglyoxal|positive regulation of transcription from RNA polymerase II promoter in response to increased salt|Unknown|positive regulation of starch catabolic process by positive regulation of transcription from RNA polymerase II promoter|positive regulation of invasive growth in response to glucose limitation by positive regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding nucleus
YLR090W YLR090W XDJ1 hom Verified 0.971346982862339 0.165687760004599 no 751 0.179519139828242 605 NA FT NUCLEUS|MITOCHONDRION Chaperone with a role in facilitating mitochondrial protein import; ascomycete-specific member of the DnaJ-like family, closely related to Ydj1p; predicted to be C-terminally prenylated; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies protein folding chaperone binding mitochondrion|integral to mitochondrial outer membrane|nucleus
YAL055W YAL055W PEX22 hom Verified 0.970100057710854 0.165998310125293 no 752 0.182071069021424 578 NA FT PROTEIN LOCALIZATION|SIGNALING|PEROXISOME ORGANIZATION Putative peroxisomal membrane protein required for import of peroxisomal proteins, functionally complements a Pichia pastoris pex22 mutation protein import into peroxisome matrix, receptor recycling|protein targeting to peroxisome protein anchor integral to peroxisomal membrane
YDL075W YDL075W RPL31A hom Verified 0.969860093157256 0.166058117083513 no 753 0.199371672568269 699 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L31A; associates with karyopherin Sxm1p; loss of both Rpl31p and Rpl39p confers lethality; homologous to mammalian ribosomal protein L31, no bacterial homolog; RPL31A has a paralog, RPL31B, that arose from the whole genome duplication cytoplasmic translation|regulation of translational fidelity structural constituent of ribosome cytosolic large ribosomal subunit
YKR096W YKR096W ESL2 hom Verified 0.969675316824895 0.166104178831562 no 754 0.173540166313817 568 NA FT NUCLEUS Protein of unknown function that interacts with Pex14p; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; predicted to contain a PINc domain biological_process molecular_function ribosome|nucleus|cytoplasm
YHR022C-A_p YHR022C-A YHR022C-A hom Uncharacterized 0.969461671162187 0.166157447525102 no 755 0.158912592121256 559 NA Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching biological_process molecular_function cellular_component
YIL157C YIL157C COA1 hom Verified 0.969458225015009 0.166158306850188 no 756 0.165492793721816 629 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial inner membrane protein required for assembly of the cytochrome c oxidase complex (complex IV); interacts with complex IV assembly factor Shy1p during the early stages of assembly mitochondrial respiratory chain complex IV assembly molecular_function integral to mitochondrial membrane|mitochondrion|integral to mitochondrial inner membrane
YOR280C YOR280C FSH3 hom Verified 0.968535291056448 0.166388551350051 no 757 0.162635277965921 547 NA Putative serine hydrolase; likely target of Cyc8p-Tup1p-Rfx1p transcriptional regulation; sequence is similar to S. cerevisiae Fsh1p and Fsh2p and the human candidate tumor suppressor OVCA2 biological_process molecular_function cellular_component
YNL224C YNL224C SQS1 hom Verified 0.967631787918281 0.166614147889078 no 758 0.159069453084782 609 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEOTIDE METABOLISM NUCLEUS Protein that stimulates the ATPase and helicase activities of Prp43p; acts with Prp43p to stimulate 18s rRNA maturation by Nob1p; overexpression antagonizes the suppression of splicing defects by spp382 mutants; component of pre-ribosomal particles; relocalizes from nucleus to nucleolus upon DNA replication stress positive regulation of helicase activity|positive regulation of ATPase activity|mRNA splicing, via spliceosome|maturation of SSU-rRNA|rRNA processing molecular_function preribosome, small subunit precursor|nucleus|preribosome, large subunit precursor|90S preribosome|cytoplasm
YDR231C YDR231C COX20 hom Verified 0.966329405427913 0.166939688193166 no 759 0.168556174176131 563 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase mitochondrial respiratory chain complex IV assembly|protein processing|aerobic respiration unfolded protein binding mitochondrion|mitochondrial inner membrane
YKR094C YKR094C RPL40B hom Verified 0.965685500173099 0.167100788607427 no 760 0.161415926957139 570 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RESPONSE TO DNA DAMAGE|TRANSLATION NUCLEUS|MITOCHONDRION RIBOSOME Ubiquitin-ribosomal 60S subunit protein L40B fusion protein; cleaved to yield ubiquitin and ribosomal protein L40B; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; homologous to mammalian ribosomal protein L40, no bacterial homolog; RPL40B has a paralog, RPL40A, that arose from the whole genome duplication cytoplasmic translation|protein ubiquitination|ribosome biogenesis structural constituent of ribosome|protein tag mitochondrion|cytosolic large ribosomal subunit
YBL088C YBL088C TEL1 hom Verified 0.964933601658894 0.167289034973163 no 761 0.162442555941859 562 NA FT CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION NUCLEUS|MITOCHONDRION|CHROMOSOME Protein kinase primarily involved in telomere length regulation; contributes to cell cycle checkpoint control in response to DNA damage; functionally redundant with Mec1p; regulates P-body formation induced by replication stress; homolog of human ataxia-telangiectasia mutated (ATM) gene, the gene responsible for ataxia telangiectasia (AT) (OMIM 607585) double-strand break repair|histone phosphorylation|telomere maintenance|response to DNA damage stimulus|phosphorylation|DNA damage induced protein phosphorylation protein kinase activity|telomeric DNA binding mitochondrion|nucleus
YEL023C_p YEL023C YEL023C hom Uncharacterized 0.964438870900541 0.167412970984018 no 762 0.169590704780093 572 NA Putative protein of unknown function; expression is increased greatly during sporulation; YEL023C is not an essential gene biological_process molecular_function cellular_component
YKL162C_p YKL162C YKL162C hom Uncharacterized 0.964179191910483 0.167478047368587 no 763 0.135034052177952 457 NA FT MITOCHONDRION Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion biological_process molecular_function mitochondrion
YOL017W YOL017W ESC8 hom Verified 0.963368295634815 0.167681365458765 no 764 0.170467346494667 589 NA FT GENE SILENCING NUCLEUS Protein involved in telomeric and mating-type locus silencing; interacts with Sir2p and also interacts with Gal11p, which is a component of the RNA pol II mediator complex; ESC8 has a paralog, IOC3, that arose from the whole genome duplication chromatin silencing molecular_function nucleus
YPL108W_p YPL108W YPL108W hom Uncharacterized 0.962233176719908 0.167966243604312 no 765 0.180381729172814 605 NA Cytoplasmic protein of unknown function; non-essential gene that is induced in a GDH1 deleted strain with altered redox metabolism; GFP-fusion protein is induced in response to the DNA-damaging agent MMS biological_process molecular_function cytoplasm
YOR348C YOR348C PUT4 hom Verified 0.960437481243985 0.168417540905569 no 766 0.186179487949333 662 NA FT PLASMA MEMBRANE Proline permease, required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells neutral amino acid transport|proline transport|gamma-aminobutyric acid transport neutral amino acid transmembrane transporter activity|L-proline transmembrane transporter activity integral to membrane|plasma membrane
YNL271C YNL271C BNI1 hom Verified 0.96039388914579 0.168428506232776 no 767 0.221055272717275 779 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNR1 barbed-end actin filament capping|actin nucleation|actin filament bundle assembly involved in cytokinetic actomyosin contractile ring assembly|establishment of mitotic spindle orientation|formin-nucleated actin cable assembly profilin binding incipient cellular bud site|actin filament|polarisome|plasma membrane|cellular bud neck|mating projection tip|cellular bud tip
YIR023W YIR023W DAL81 hom Verified 0.95967196928343 0.168610167537681 no 768 0.312278386764187 1075 NA FF|FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM|RESPONSE TO NUTRIENT LEVELS NUCLEUS Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism nitrogen utilization|nitrogen catabolite activation of transcription from RNA polymerase II promoter|gamma-aminobutyric acid catabolic process|urea catabolic process RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly|RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II transcription factor recruiting transcription factor activity nucleus
YAL047C YAL047C SPC72 hom Verified 0.958949425177659 0.168792111987975 no 769 0.175327620583147 566 NA FT CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION NUCLEUS|CYTOSKELETON Component of the cytoplasmic Tub4p (gamma-tubulin) complex, binds spindle pole bodies and links them to microtubules; has roles in astral microtubule formation and stabilization microtubule nucleation|nuclear migration along microtubule|mitotic cell cycle spindle orientation checkpoint|mitotic spindle elongation|mitotic sister chromatid segregation structural constituent of cytoskeleton outer plaque of spindle pole body
YGL177W_d YGL177W YGL177W hom Dubious 0.957489288385147 0.169160175200097 no 770 0.201342099382883 683 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YFR009W YFR009W GCN20 hom Verified 0.956728180948846 0.169352235123707 no 771 0.218341394925551 770 NA FF|FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|NUCLEOTIDE METABOLISM RIBOSOME Positive regulator of the Gcn2p kinase activity, forms a complex with Gcn1p; proposed to stimulate Gcn2p activation by an uncharged tRNA regulation of translational elongation ATPase activity cytosol|cytosolic ribosome
YOL097W-A_p YOL097W-A YOL097W-A hom Uncharacterized 0.95572328901704 0.169606026587024 no 772 0.173622158887287 558 NA Putative protein of unknown function; identified by expression profiling and mass spectrometry biological_process molecular_function cellular_component
YGR051C_d YGR051C YGR051C hom Dubious 0.955603821278723 0.169636215097799 no 773 0.156058637215384 575 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YGR051C is not an essential gene Unknown Unknown Unknown
YOR038C YOR038C HIR2 hom Verified 0.955157900960904 0.169748925920516 no 774 0.161000123731119 530 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION NUCLEUS Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; recruits Swi-Snf complexes to histone gene promoters; promotes heterochromatic gene silencing with Asf1p DNA replication-independent nucleosome assembly|regulation of transcription from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter nucleosome binding|transcription corepressor activity|DNA binding HIR complex|nucleus
YJL122W YJL122W ALB1 hom Verified 0.955062233018927 0.169773113206063 no 775 0.141430585946346 506 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS NUCLEUS Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit; interacts directly with Arx1p; responsible for Tif6p recycling defects in absence of Rei1p ribosomal large subunit biogenesis molecular_function ribosome|nucleus|cytoplasm
YBR280C YBR280C SAF1 hom Verified 0.954494642420618 0.169916659977328 no 776 0.16997505987696 584 NA FT PROTEOLYSIS UBIQUITIN LIGASE COMPLEX F-Box protein involved in proteasome-dependent degradation of Aah1p during entry of cells into quiescence; interacts with Skp1 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ubiquitin-protein ligase activity SCF ubiquitin ligase complex
YKR040C_d YKR040C YKR040C hom Dubious 0.953865203571404 0.170075939475559 no 777 0.160839585788788 541 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YKR041W Unknown Unknown Unknown
YHR010W YHR010W RPL27A hom Verified 0.953315603469703 0.170215094008416 no 778 0.14461663059965 563 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L27A; homologous to mammalian ribosomal protein L27, no bacterial homolog; RPL27A has a paralog, RPL27B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YMR199W YMR199W CLN1 hom Verified 0.952471574296311 0.170428937719854 no 779 0.149354525328798 551 NA FT CELL CYCLE|CELL DIVISION|PROTEIN PHOSPHORYLATION NUCLEUS G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p) regulation of cyclin-dependent protein kinase activity cyclin-dependent protein kinase regulator activity nucleus|cytoplasm
YPR049C YPR049C ATG11 hom Verified 0.95100899658816 0.170799904450733 no 780 0.185594623126296 635 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|PEROXISOME ORGANIZATION Adapter protein for pexophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; directs receptor-bound cargo to the phagophore assembly site (PAS) for packaging into vesicles; required for recruiting other proteins to the (PAS) piecemeal microautophagy of nucleus|mitochondrion degradation|peroxisome degradation|protein localization to pre-autophagosomal structure|CVT pathway protein complex scaffold pre-autophagosomal structure|extrinsic to membrane
YDR350C YDR350C ATP22 hom Verified 0.950833570665353 0.170844433986067 no 781 0.179806863289541 610 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Specific translational activator for the mitochondrial ATP6 mRNA, encoding a subunit of F1F0 ATP synthase; localized to the mitochondrial inner membrane proton-transporting ATP synthase complex biogenesis|positive regulation of mitochondrial translation translation regulator activity mitochondrial inner membrane
YJL106W YJL106W IME2 hom Verified 0.950467602833289 0.170937353960822 no 782 0.161584712233451 535 NA FT CELL CYCLE|PROTEIN PHOSPHORYLATION NUCLEUS Serine/threonine protein kinase involved in activation of meiosis, associates with Ime1p and mediates its stability, activates Ndt80p; IME2 expression is positively regulated by Ime1p protein phosphorylation|regulation of meiosis protein kinase activity nucleus
YNL338W_d YNL338W YNL338W hom Dubious 0.95016335665028 0.171014627292403 no 783 0.154600014573278 563 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps TEL14L-XC, which is Telomeric X element Core sequence on the left arm of Chromosome XIV Unknown Unknown Unknown
YHL023C YHL023C NPR3 hom Verified 0.949763630058792 0.171116184975041 no 784 0.186076441467562 621 NA FT CELL CYCLE|SIGNALING|RESPONSE TO NUTRIENT LEVELS Subunit of SEA (Seh1-associated), Npr2/3, and Iml1p complexes; Npr2/3 complex mediates downregulation of TORC1 activity upon amino acid limitation; SEA complex is a coatomer-related complex that associates dynamically with the vacuole; Iml1p complex (Iml1p-Npr2p-Npr3p) is required for non-nitrogen-starvation (NNS)-induced autophagy; required for Npr2p phosphorylation and Iml1p-Npr2p interaction; null mutant shows delayed meiotic DNA replication and double-strand break repair meiosis|regulation of TOR signaling cascade|cellular response to amino acid starvation molecular_function Seh1-associated complex|extrinsic to fungal-type vacuolar membrane
YDR536W YDR536W STL1 hom Verified 0.949272209237907 0.171241092061886 no 785 0.171105755985891 613 NA FT PLASMA MEMBRANE Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock transport|glycerol transport|transmembrane transport solute:hydrogen symporter activity|transporter activity integral to membrane|plasma membrane|membrane
YMR052C-A_d YMR052C-A YMR052C-A hom Dubious 0.947313683053133 0.171739480225123 no 786 0.170979452190511 627 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YLR220W YLR220W CCC1 hom Verified 0.947301286713443 0.171742637682178 no 787 0.161998055156018 572 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Putative vacuolar Fe2+/Mn2+ transporter; suppresses respiratory deficit of yfh1 mutants, which lack the ortholog of mammalian frataxin, by preventing mitochondrial iron accumulation; relative distribution to the vacuole decreases upon DNA replication stress manganese ion transport|cellular calcium ion homeostasis|cellular iron ion homeostasis|cellular manganese ion homeostasis|ferrous iron transport manganese ion transmembrane transporter activity|ferrous iron transmembrane transporter activity fungal-type vacuole membrane|integral to membrane|Golgi apparatus
YIL153W YIL153W RRD1 hom Verified 0.947106054299537 0.171792369990312 no 788 0.192945735914077 694 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|RESPONSE TO DNA DAMAGE|CYTOSKELETON ORGANIZATION NUCLEUS|CHROMOSOME Peptidyl-prolyl cis/trans-isomerase; activator of the phosphotyrosyl phosphatase activity of PP2A; involved in G1 phase progression, microtubule dynamics, bud morphogenesis and DNA repair; required for rapid reduction of Sgs1p levels in response to rapamycin; subunit of the Tap42p-Sit4p-Rrd1p complex; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress DNA repair|mitotic spindle organization in nucleus|G1/S transition of mitotic cell cycle|response to osmotic stress|regulation of transcription from RNA polymerase II promoter in response to stress peptidyl-prolyl cis-trans isomerase activity|protein phosphatase type 2A regulator activity nuclear chromatin|nucleus|cytoplasm
YJR128W_d YJR128W YJR128W hom Dubious 0.945919621904615 0.172094792258572 no 789 0.161389563952149 490 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RSF2 Unknown Unknown Unknown
YLR126C YLR126C YLR126C hom Verified 0.945658217691189 0.172161469990688 no 790 0.160122454766462 572 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|ION HOMEOSTASIS|ION HOMEOSTASIS Putative glutamine amidotransferase; has Aft1p-binding motif in the promoter; may be involved in copper and iron homeostasis; YLR126C is not an essential protein; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress cellular copper ion homeostasis|cellular iron ion homeostasis molecular_function cytoplasm
YJR147W YJR147W HMS2 hom Verified 0.944549307515744 0.172444508761716 no 791 0.14707470367508 471 NA FT NUCLEUS Protein with similarity to heat shock transcription factors; overexpression suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant; HMS2 has a paralog, SKN7, that arose from the whole genome duplication pseudohyphal growth molecular_function nucleus|cytoplasm
YJL211C_d YJL211C YJL211C hom Dubious 0.944507700055337 0.172455134443784 no 792 0.171127654529489 570 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL210W/PEX2 Unknown Unknown Unknown
YER032W YER032W FIR1 hom Verified 0.944394802105126 0.172483968341502 no 793 0.195014535936513 633 NA FT RNA PROCESSING SITE OF POLARIZED GROWTH Protein involved in 3' mRNA processing, interacts with Ref2p; potential Cdc28p substrate mRNA polyadenylation|RNA polyadenylation molecular_function cellular bud neck
YPL232W YPL232W SSO1 hom Verified 0.943469490492811 0.172720406827701 no 794 0.179392060901491 654 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION PLASMA MEMBRANE Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane and in vesicle fusion during sporulation; forms a complex with Sec9p that binds v-SNARE Snc2p; syntaxin homolog; functionally redundant with Sso2p ascospore formation|ascospore-type prospore assembly|vesicle fusion phosphatidic acid binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|SNAP receptor activity SNARE complex|fungal-type vacuole membrane|plasma membrane|prospore membrane
YER058W YER058W PET117 hom Verified 0.943016569649816 0.172836213841284 no 795 0.160150209877079 586 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Protein required for assembly of cytochrome c oxidase mitochondrial respiratory chain complex IV assembly molecular_function mitochondrion
YDR316W YDR316W OMS1 hom Verified 0.940817820578909 0.173399113460693 no 796 0.19979154297768 706 NA FT MITOCHONDRION Protein integral to the mitochondrial membrane; has a conserved methyltransferase motif; multicopy suppressor of respiratory defects caused by OXA1 mutations biological_process S-adenosylmethionine-dependent methyltransferase activity mitochondrial envelope|mitochondrion
YGR268C YGR268C HUA1 hom Verified 0.939370479435903 0.173770282061456 no 797 0.190700663978134 670 NA Cytoplasmic protein containing a zinc finger domain with sequence similarity to that of Type I J-proteins; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin patch assembly biological_process molecular_function cytoplasm
YPR114W_p YPR114W YPR114W hom Uncharacterized 0.938299160796917 0.174045345454974 no 798 0.183913371546627 638 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Putative protein of unknown function biological_process molecular_function integral to membrane|endoplasmic reticulum
YFR021W YFR021W ATG18 hom Verified 0.938059967153377 0.174106796722778 no 799 0.181116025022288 628 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS|PEROXISOME ORGANIZATION|VACUOLAR PROTEIN PROCESSING Phosphoinositide binding protein; required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; binds both phosphatidylinositol (3,5)-bisphosphate and phosphatidylinositol 3-phosphate; WD-40 repeat protein; relocalizes from vacuole to cytoplasm upon DNA replication stress; has 4 mammalian homologs WIPI1, WIPI2, WIPI3 and WIPI4/WDR45; mutations in human WDR45 cause static encephalopathy of childhood with neurodegeneration in adulthood piecemeal microautophagy of nucleus|peroxisome degradation|vacuolar protein processing|macroautophagy|late endosome to vacuole transport|CVT pathway ubiquitin binding|phosphatidylinositol binding cytosol|endosome|fungal-type vacuole membrane|PAS complex|pre-autophagosomal structure
YPL017C YPL017C IRC15 hom Verified 0.937395560634308 0.174277561830756 no 800 0.206305901081044 709 NA FT PROTEIN LOCALIZATION|CELL CYCLE|OXIDATION-REDUCTION PROCESS|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION CYTOSKELETON Microtubule associated protein; regulates microtubule dynamics; required for accurate meiotic chromosome segregation; null mutant displays large budded cells due to delayed mitotic progression, increased levels of spontaneous Rad52 foci microtubule nucleation|mitotic recombination|microtubule anchoring|meiotic sister chromatid segregation|attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation|positive regulation of mitotic cell cycle microtubule binding|S-adenosylmethionine-dependent methyltransferase activity microtubule|cytoplasm
YKL005C YKL005C BYE1 hom Verified 0.936920165544139 0.174399812702916 no 801 0.162013320074823 537 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Negative regulator of transcription elongation, contains a TFIIS-like domain and a PHD finger, multicopy suppressor of temperature-sensitive ess1 mutations, probably binds RNA polymerase II large subunit negative regulation of transcription from RNA polymerase II promoter methylated histone residue binding nucleus
YGL219C YGL219C MDM34 hom Verified 0.935238809240421 0.174832621095706 no 802 0.214628021363603 707 NA FT MITOCHONDRION ORGANIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION Mitochondrial component of the ERMES complex that links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth mitochondrion organization|phospholipid transport molecular_function mitochondrial outer membrane|ERMES complex|mitochondrion|cytoplasm
YIL165C_p YIL165C YIL165C hom Uncharacterized 0.933299258595987 0.175332738926199 no 803 0.155493844927737 553 NA Putative protein of unknown function; mutant exhibits mitophagy defects; in closely related species and other S. cerevisiae strain backgrounds YIL165C and adjacent ORF, YIL164C, likely constitute a single ORF encoding a nitrilase gene mitochondrion degradation molecular_function cellular_component
YOR314W_d YOR314W YOR314W hom Dubious 0.933254038106358 0.17534440994928 no 804 0.169069719989054 606 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YKL068W YKL068W NUP100 hom Verified 0.933237337682207 0.175348720311004 no 805 0.16139391423799 583 NA FT PROTEIN LOCALIZATION|RNA LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS NUCLEAR PORE FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier and is involved in gene tethering at the nuclear periphery; homologous to Nup116p positive regulation of transcription, DNA-dependent|mRNA export from nucleus|NLS-bearing substrate import into nucleus|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|protein import into nucleus|protein targeting to nuclear inner membrane|mRNA export from nucleus in response to heat stress nucleocytoplasmic transporter activity|structural constituent of nuclear pore nuclear pore central transport channel|integral to membrane|nuclear pore
YNL094W YNL094W APP1 hom Verified 0.932992133768822 0.175412014914669 no 806 0.194814951754647 677 NA FT CYTOSKELETON ORGANIZATION CYTOSKELETON Phosphatidate phosphatase, converts phosphatidate to diacylglycerol; App1p, Pah1p, Dpp1p, and Lpp1p are responsible for all the phosphatidate phosphatase activity; component of cortical actin patches; interacts with components of endocytic pathway actin cytoskeleton organization molecular_function actin cytoskeleton|actin cortical patch
YDR490C YDR490C PKH1 hom Verified 0.932900953500839 0.175435555014764 no 807 0.159092327341271 576 NA FT VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|RNA PROCESSING|SIGNALING|CELL WALL ORG/BIOGENESIS|PROTEIN PHOSPHORYLATION Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; redundant with Pkh2p regulation of nuclear-transcribed mRNA poly(A) tail shortening|endocytosis|protein phosphorylation|MAPK cascade involved in cell wall biogenesis|cytoplasmic mRNA processing body assembly protein kinase activity cytosol|cell cortex|eisosome
YKL133C_p YKL133C YKL133C hom Uncharacterized 0.932364477563774 0.175574098089135 no 808 0.194978745956431 632 NA Putative protein of unknown function; has similarity to Mgr3p, but unlike MGR3, is not required for growth of cells lacking the mitochondrial genome (null mutation does not confer a petite-negative phenotype) biological_process molecular_function cellular_component
YDR175C YDR175C RSM24 hom Verified 0.932218902702167 0.175611704255499 no 809 0.187128100969982 631 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the small subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial small ribosomal subunit
YGL181W YGL181W GTS1 hom Verified 0.930532957999002 0.176047603981061 no 810 0.18001922142362 579 NA FT VESICLE-MEDIATED TRANSPORT|TRANSCRIPTION FROM RNA POL II|LIPID METABOLISM|MEMBRANE ORGANIZATION|SIGNALING|NUCLEOTIDE METABOLISM NUCLEUS|CYTOSKELETON Protein involved in Arf3p regulation and in transcription regulation; localizes to the nucleus and to endocytic patches; contains an N-terminal Zn-finger and ArfGAP homology domain, a C-terminal glutamine-rich region, and a UBA (ubiquitin associated) domain; gts1 mutations affect budding, cell size, heat tolerance, sporulation, life span, ultradian rhythms, endocytosis; expression oscillates in a pattern similar to metabolic oscillations endocytosis|ultradian rhythm|regulation of transcription from RNA polymerase II promoter|negative regulation of phosphatidylinositol biosynthetic process|positive regulation of transcription from RNA polymerase II promoter ARF GTPase activator activity|repressing transcription factor binding|transcription factor binding transcription factor activity nucleus|cytoplasm|actin cortical patch
YDR092W YDR092W UBC13 hom Verified 0.929794751348357 0.176238682199587 no 811 0.1613986203297 570 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RESPONSE TO DNA DAMAGE NUCLEUS Ubiquitin-conjugating enzyme involved in the error-free DNA postreplication repair pathway; interacts with Mms2p to assemble ubiquitin chains at the Ub Lys-63 residue; DNA damage triggers redistribution from the cytoplasm to the nucleus postreplication repair|protein monoubiquitination|protein polyubiquitination|free ubiquitin chain polymerization ubiquitin-protein ligase activity ubiquitin conjugating enzyme complex|nucleus|cytoplasm
YHR034C YHR034C PIH1 hom Verified 0.929462797555273 0.17632464824683 no 812 0.198834873674716 667 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Component of the conserved R2TP complex (Rvb1-Rvb2-Tah1-Pih1); R2TP complex interacts with Hsp90 (Hsp82p and Hsc82p) to mediate assembly large protein complexes such as box C/D snoRNPs and RNA polymerase II protein folding|rRNA processing|regulation of cell size|box C/D snoRNP assembly molecular_function R2TP complex|nucleus|small nucleolar ribonucleoprotein complex|cytoplasm
YGR027C YGR027C RPS25A hom Verified 0.927288496387244 0.17688838272569 no 813 0.20325503716527 683 NA FT TRANSLATION RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S25, no bacterial homolog; RPS25A has a paralog, RPS25B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic small ribosomal subunit
YAL046C YAL046C AIM1 hom Verified 0.927103874445521 0.176936302356974 no 814 0.186601249155877 655 NA Protein involved in mitochondrial function or organization; null mutant displays elevated frequency of mitochondrial genome loss biological_process molecular_function cellular_component
YMR015C YMR015C ERG5 hom Verified 0.92677164984936 0.177022553722965 no 815 0.229335702951596 825 NA FF|FT LIPID METABOLISM|OXIDATION-REDUCTION PROCESS ENDOPLASMIC RETICULUM C-22 sterol desaturase, a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis; may be a target of azole antifungal drugs ergosterol biosynthetic process C-22 sterol desaturase activity endoplasmic reticulum
YJR087W_d YJR087W YJR087W hom Dubious 0.926528199224066 0.177085774663018 no 816 0.169246311935245 621 NA Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified genes STE18 and ECM2 Unknown Unknown Unknown
YNR005C_d YNR005C YNR005C hom Dubious 0.92642297260431 0.177113105052991 no 817 0.197830457996201 699 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YDR525W-A YDR525W-A SNA2 hom Verified 0.925854571765582 0.177260781221227 no 818 0.176687001519601 637 NA Protein of unknown function, has similarity to Pmp3p, which is involved in cation transport; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern biological_process molecular_function fungal-type vacuole membrane|integral to membrane|cytoplasm
YLR172C YLR172C DPH5 hom Verified 0.925782213952007 0.177279586075878 no 819 0.189151777160888 648 NA Methyltransferase required for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); not essential for viability; GFP-Dph5p fusion protein localizes to the cytoplasm peptidyl-diphthamide biosynthetic process from peptidyl-histidine diphthine synthase activity cytoplasm
YEL036C YEL036C ANP1 hom Verified 0.925321311016227 0.177399398322065 no 820 0.220304154832889 754 NA FT CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS Subunit of the alpha-1,6 mannosyltransferase complex; type II membrane protein; has a role in retention of glycosyltransferases in the Golgi; involved in osmotic sensitivity and resistance to aminonitrophenyl propanediol protein N-linked glycosylation alpha-1,6-mannosyltransferase activity|mannosyltransferase activity alpha-1,6-mannosyltransferase complex|Golgi cis cisterna
YHL003C YHL003C LAG1 hom Verified 0.92408931097933 0.177719909026693 no 821 0.147862785821238 511 NA FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Ceramide synthase component; involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p; forms ER foci upon DNA replication stress replicative cell aging|ceramide biosynthetic process sphingosine N-acyltransferase activity integral to membrane|endoplasmic reticulum
YPR087W_d YPR087W VPS69 hom Dubious 0.923143030042096 0.177966336455798 no 822 0.201398176016748 671 NA Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 85% of ORF overlaps the verified gene SRP54; deletion causes a vacuolar protein sorting defect Unknown Unknown Unknown
YMR251W YMR251W GTO3 hom Verified 0.922489416132877 0.178136674234221 no 823 0.189734080766005 624 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Omega class glutathione transferase; putative cytosolic localization glutathione metabolic process glutathione transferase activity cytoplasm
YDL025C YDL025C RTK1 hom Verified 0.921781756536784 0.178321212644106 no 824 0.22245679225292 736 NA FT PROTEIN PHOSPHORYLATION Putative protein kinase, potentially phosphorylated by Cdc28p; interacts with ribosome biogenesis factors, Cka2, Gus1 and Arc1; protein abundance increases in response to DNA replication stress biological_process protein serine/threonine kinase activity|protein kinase activity cellular_component
YOR385W_p YOR385W YOR385W hom Uncharacterized 0.921606313369971 0.17836698208661 no 825 0.180714932651831 659 NA Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YOR385W is not an essential gene biological_process molecular_function cytoplasm
YDR322W YDR322W MRPL35 hom Verified 0.920379453951335 0.178687250801136 no 826 0.200331824424213 666 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YGR101W YGR101W PCP1 hom Verified 0.918173054492739 0.179264136574944 no 827 0.194421499209907 645 NA FT PROTEOLYSIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial serine protease required for the processing of various mitochondrial proteins and maintenance of mitochondrial DNA and morphology; belongs to the rhomboid-GlpG superfamily of intramembrane peptidases signal peptide processing|regulation of mitochondrion organization serine-type endopeptidase activity integral to membrane|mitochondrial inner membrane
YHR038W YHR038W RRF1 hom Verified 0.918031089685027 0.179301294792764 no 828 0.19600354401391 667 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial ribosome recycling factor, essential for mitochondrial protein synthesis and for the maintenance of the respiratory function of mitochondria mitochondrial translation translation release factor activity mitochondrion
YKL057C YKL057C NUP120 hom Verified 0.917635546383812 0.179404850813754 no 829 0.218667158760018 750 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RNA LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS NUCLEAR PORE Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport and NPC biogenesis and is involved in establishment of a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p; also plays roles in several processes that may require localization of genes or chromosomes at the nuclear periphery, including double-strand break repair, transcription and chromatin silencing; homologous to human NUP160 double-strand break repair|protein export from nucleus|ribosomal large subunit export from nucleus|maintenance of chromatin silencing at telomere|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|telomere tethering at nuclear periphery|nuclear pore distribution|mRNA export from nucleus in response to heat stress|mRNA export from nucleus|positive regulation of transcription, DNA-dependent|negative regulation of transcription from RNA polymerase II promoter|protein import into nucleus|positive regulation of transcription from RNA polymerase II promoter structural constituent of nuclear pore integral to membrane|nuclear pore|nuclear pore outer ring
YBR041W YBR041W FAT1 hom Verified 0.917487059484953 0.179443735434758 no 830 0.218292005166749 718 NA FT KETONE METABOLISM|LIPID METABOLISM ENDOPLASMIC RETICULUM|PLASMA MEMBRANE Very long chain fatty acyl-CoA synthetase and long chain fatty acid transporter; activates imported fatty acids with a preference for very long lengths (C20-C26); has a separate function in the transport of long chain fatty acids very long-chain fatty acid metabolic process|long-chain fatty acid transport very long-chain fatty acid-CoA ligase activity|long-chain fatty acid transporter activity intrinsic to internal side of plasma membrane|integral to membrane|endoplasmic reticulum|lipid particle|peroxisome
YGL176C_p YGL176C YGL176C hom Uncharacterized 0.913882623723434 0.180389262522424 no 831 0.191594362214683 635 NA Putative protein of unknown function; deletion mutant is viable and has no detectable phenotype biological_process molecular_function cellular_component
YPL240C YPL240C HSP82 hom Verified 0.913610624681032 0.180460740797996 no 832 0.196579755563763 689 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION Hsp90 chaperone; redundant in function with Hsc82p; required for pheromone signaling, negative regulation of Hsf1p; docks with Tom70p for mitochondrial preprotein delivery; promotes telomerase DNA binding, nucleotide addition; protein abundance increases in response to DNA replication stress; contains two acid-rich unstructured regions that promote solubility of chaperone-substrate complexes; HSP82 has a paralog, HSC82, that arose from the whole genome duplication proteasome assembly|positive regulation of telomere maintenance via telomerase|box C/D snoRNP assembly|response to stress|protein refolding|protein targeting to mitochondrion|response to osmotic stress|'de novo' protein folding unfolded protein binding|ATPase activity, coupled cytoplasm
YLR099C YLR099C ICT1 hom Verified 0.912851452995731 0.180660336523596 no 833 0.184357883187124 663 NA FT KETONE METABOLISM|LIPID METABOLISM Lysophosphatidic acid acyltransferase; responsible for enhanced phospholipid synthesis during organic solvent stress; null displays increased sensitivity to Calcofluor white; highly expressed during organic solvent stress; ICT1 has a paralog, ECM18, that arose from the whole genome duplication phosphatidic acid biosynthetic process lysophosphatidic acid acyltransferase activity cellular_component
YPL158C YPL158C AIM44 hom Verified 0.912561909946282 0.180736497461988 no 834 0.223632302450408 755 NA FT SITE OF POLARIZED GROWTH Protein of unknown function; GFP-fusion protein localizes to the bud neck; transcription is regulated by Swi5p; null mutant displays elevated frequency of mitochondrial genome loss; relocalizes from bud neck to cytoplasm upon DNA replication stress biological_process molecular_function cellular bud neck
YDR137W YDR137W RGP1 hom Verified 0.912555221500402 0.180738257017876 no 835 0.265103133100897 905 NA FF|FT VESICLE-MEDIATED TRANSPORT|CELL CYCLE|CELL DIVISION ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) that catalyzes nucleotide exchange on Ypt6p retrograde transport, endosome to Golgi guanyl-nucleotide exchange factor activity Golgi apparatus|Ric1p-Rgp1p complex|Golgi membrane|guanyl-nucleotide exchange factor complex
YBL098W YBL098W BNA4 hom Verified 0.910970240241131 0.181155527092395 no 836 0.170370036918519 653 NA FT OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM MITOCHONDRION Kynurenine 3-mono oxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p; putative therapeutic target for Huntington disease de novo NAD biosynthetic process from tryptophan kynurenine 3-monooxygenase activity mitochondrial outer membrane|mitochondrion
YOR144C YOR144C ELG1 hom Verified 0.910715068648805 0.181222761190135 no 837 0.173790552822014 622 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION NUCLEUS|MITOCHONDRION|CHROMOSOME Subunit of an alternative replication factor C complex important for DNA replication and genome integrity; suppresses spontaneous DNA damage; involved in homologous recombination-mediated repair and telomere homeostasis; required for PCNA (Pol30p) unloading during DNA replication negative regulation of DNA recombination|negative regulation of transposition, RNA-mediated|telomere maintenance|double-strand break repair via homologous recombination|DNA-dependent DNA replication|mitotic sister chromatid cohesion chromatin binding Elg1 RFC-like complex|mitochondrion|nucleus|cytoplasm
YMR215W YMR215W GAS3 hom Verified 0.909825576672242 0.181457251887705 no 838 0.169374215161166 573 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM Low abundance, possibly inactive member of the GAS family of GPI-containing proteins; putative 1,3-beta-glucanosyltransferase with similarity to other GAS family members; localizes to the cell wall; mRNA induced during sporulation biological_process 1,3-beta-glucanosyltransferase activity fungal-type cell wall|integral to membrane|plasma membrane
YGL236C YGL236C MTO1 hom Verified 0.909518820865471 0.181538163853768 no 839 0.199574996211032 658 NA FT RNA PROCESSING|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial protein, forms a heterodimer complex with Mss1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; required for respiration in paromomycin-resistant 15S rRNA mutants mitochondrial tRNA wobble uridine modification molecular_function mitochondrion
YNL284C YNL284C MRPL10 hom Verified 0.909349016118791 0.181582962399096 no 840 0.190945348105647 671 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL10 and YmL18) on two-dimensional SDS gels mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YAL007C YAL007C ERP2 hom Verified 0.909224054847543 0.181615934583994 no 841 0.182179196828295 627 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Protein that forms a heterotrimeric complex with Erp1p, Emp24p, and Erv25p; member, along with Emp24p and Erv25p, of the p24 family involved in ER to Golgi transport and localized to COPII-coated vesicles ER to Golgi vesicle-mediated transport molecular_function ER to Golgi transport vesicle
YIL024C_p YIL024C YIL024C hom Uncharacterized 0.909171057409402 0.181629919578645 no 842 0.17091070626524 598 NA Putative protein of unknown function; non-essential gene; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p biological_process molecular_function cellular_component
YKR036C YKR036C CAF4 hom Verified 0.90894473920252 0.181689648141109 no 843 0.169840953686579 579 NA FT TRANSCRIPTION FROM RNA POL II|MITOCHONDRION ORGANIZATION|PEROXISOME ORGANIZATION NUCLEUS|MITOCHONDRION WD40 repeat-containing protein associated with the CCR4-NOT complex; interacts in a Ccr4p-dependent manner with Ssn2p; also interacts with Fis1p, Mdv1p and Dnm1p and plays a role in mitochondrial fission; CAF4 has a paralog, MDV1, that arose from the whole genome duplication peroxisome fission|mitochondrial fission|regulation of transcription from RNA polymerase II promoter molecular_function mitochondrion|CCR4-NOT complex
YDL040C YDL040C NAT1 hom Verified 0.908866212311577 0.181710375365222 no 844 0.17533048977296 623 NA FT MITOCHONDRION RIBOSOME Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing N-terminal protein amino acid acetylation peptide alpha-N-acetyltransferase activity mitochondrion|NatA complex|cytosolic ribosome
YNR020C YNR020C ATP23 hom Verified 0.908741258569069 0.181743360036961 no 845 0.201979293331612 657 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Putative metalloprotease of the mitochondrial inner membrane, required for processing of Atp6p; has an additional role in assembly of the F0 sector of the F1F0 ATP synthase complex; substrate of the Mia40p-Erv1p disulfide relay system, and folding is assisted by Mia40p protein processing|mitochondrial proton-transporting ATP synthase complex assembly metalloendopeptidase activity mitochondrial inner membrane|mitochondrial intermembrane space
YIL167W YIL167W SDL1 hom pseudogene 0.908695079936774 0.181755550992138 no 846 0.183016073913351 625 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Open reading frame, unlikely to produce a functional protein in S288C; in closely related species and other S. cerevisiae strain backgrounds YIL167W and adjacent ORF, YIL168W, constitute a single ORF encoding L-serine dehydratase serine family amino acid metabolic process L-serine ammonia-lyase activity cellular_component
YHR044C YHR044C DOG1 hom Verified 0.908555870460489 0.18179230477524 no 847 0.159456576978248 550 NA FT CARBOHYDRATE METABOLISM 2-deoxyglucose-6-phosphate phosphatase; paralogous to DOG2; member of a family of low molecular weight phosphatases; confers 2-deoxyglucose resistance when overexpressed, in vivo substrate has not yet been identified glucose metabolic process 2-deoxyglucose-6-phosphatase activity cellular_component
YOR120W YOR120W GCY1 hom Verified 0.908310373140927 0.181857131771585 no 848 0.21990727979693 717 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|RESPONSE TO OXIDATIVE STRESS NUCLEUS Glycerol dehydrogenase;involved in an alternative pathway for glycerol catabolism used under microaerobic conditions; also has mRNA binding activity; member of the aldo-keto reductase (AKR) family; protein abundance increases in response to DNA replication stress; GCY1 has a paralog, YPR1, that arose from the whole genome duplication cellular response to oxidative stress|arabinose catabolic process|D-xylose catabolic process oxidoreductase activity|mRNA binding|alditol:NADP+ 1-oxidoreductase activity|aldo-keto reductase (NADP) activity nucleus|cytoplasm
YFR030W YFR030W MET10 hom Verified 0.908098714106526 0.181913034901592 no 849 0.182453488917367 629 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY Subunit alpha of assimilatory sulfite reductase, which converts sulfite into sulfide sulfate assimilation sulfite reductase (NADPH) activity sulfite reductase complex (NADPH)
YDR055W YDR055W PST1 hom Verified 0.907910865686032 0.181962658201564 no 850 0.180550406495621 573 NA FT CELL WALL ORG/BIOGENESIS PLASMA MEMBRANE Cell wall protein that contains a putative GPI-attachment site; secreted by regenerating protoplasts; up-regulated by activation of the cell integrity pathway, as mediated by Rlm1p; upregulated by cell wall damage via disruption of FKS1 fungal-type cell wall organization molecular_function fungal-type cell wall|plasma membrane
YPL250C YPL250C ICY2 hom Verified 0.906886661459333 0.182233367738558 no 851 0.205648620141122 718 NA Protein of unknown function; mobilized into polysomes upon a shift from a fermentable to nonfermentable carbon source; potential Cdc28p substrate mitochondrion degradation molecular_function cellular_component
YPL207W YPL207W TYW1 hom Verified 0.906001938223809 0.182467413274507 no 852 0.17940287835409 653 NA FT RNA PROCESSING|OXIDATION-REDUCTION PROCESS ENDOPLASMIC RETICULUM Iron-sulfer protein required for synthesis of Wybutosine modified tRNA; Wybutosine is a modified guanosine found at the 3'-position adjacent to the anticodon of phenylalanine tRNA which supports reading frame maintenance by stabilizing codon-anticodon interactions; induction by Yap5p in response to iron provides protection from high iron toxicity; overexpression results in increased cellular iron wybutosine biosynthetic process molecular_function endoplasmic reticulum
YPL013C YPL013C MRPS16 hom Verified 0.905598438556221 0.182574217782875 no 853 0.203324449587442 675 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the small subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial small ribosomal subunit
YHR198C YHR198C AIM18 hom Verified 0.905389272500418 0.182629598439098 no 854 0.18360557086331 658 NA FT KETONE METABOLISM|AMINO ACID METABOLISM MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss biological_process molecular_function mitochondrion
YDL183C YDL183C YDL183C hom Verified 0.905247424404083 0.182667161365031 no 855 0.20928442120717 681 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION Mitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system; non-essential gene potassium ion transport|proton transport molecular_function integral to mitochondrial inner membrane
YER113C YER113C TMN3 hom Verified 0.905154266439983 0.182691833236121 no 856 0.173191078181915 637 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Protein with a role in cellular adhesion and filamentous growth; similar to Emp70p and Tmn2p; member of Transmembrane Nine family with 9 transmembrane segments; localizes to Golgi; induced by 8-methoxypsoralen plus UVA irradiation cellular copper ion homeostasis|vacuolar transport|pseudohyphal growth|invasive growth in response to glucose limitation molecular_function COPI-coated vesicle|integral to membrane|Golgi apparatus
YFL025C YFL025C BST1 hom Verified 0.904798215587186 0.182786148593503 no 857 0.262752012354036 911 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|PROTEOLYSIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM GPI inositol deacylase of the ER that negatively regulates COPII vesicle formation, prevents production of vesicles with defective subunits, required for proper discrimination between resident ER proteins and Golgi-bound cargo molecules protein retention in ER lumen|vesicle organization|ER-associated protein catabolic process|ER to Golgi vesicle-mediated transport|GPI anchor metabolic process phosphatidylinositol deacylase activity integral to membrane|endoplasmic reticulum
YBR194W YBR194W AIM4 hom Verified 0.903518133302592 0.183125484364402 no 858 0.224842821782064 747 NA Protein proposed to be associated with the nuclear pore complex; null mutant is viable, displays elevated frequency of mitochondrial genome loss and is sensitive to freeze-thaw stress biological_process molecular_function cytoplasm
YML102W YML102W CAC2 hom Verified 0.903445019594404 0.183144877862551 no 859 0.185764998449098 627 NA FT CHROMATIN ORGANIZATION NUCLEUS|CHROMOSOME Subunit of chromatin assembly factor I (CAF-1), with Rlf2p and Msi1p; chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of the DNA damage checkpoint after DNA repair; and chromatin dynamics during transcription DNA replication-dependent nucleosome assembly histone binding chromosome, centromeric region|CAF-1 complex
YKR046C YKR046C PET10 hom Verified 0.903319033265913 0.183178298891826 no 860 0.174751308911311 584 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY Protein of unknown function that co-purifies with lipid particles; expression pattern suggests a role in respiratory growth; computational analysis of large-scale protein-protein interaction data suggests a role in ATP/ADP exchange aerobic respiration molecular_function lipid particle
YNR059W YNR059W MNT4 hom Verified 0.903246537599038 0.183197531907418 no 861 0.181524167186924 636 NA FT CARBOHYDRATE METABOLISM Putative alpha-1,3-mannosyltransferase, not required for protein O-glycosylation protein O-linked glycosylation alpha-1,3-mannosyltransferase activity cellular_component
YDR524C-B_p YDR524C-B YDR524C-B hom Uncharacterized 0.901682815847561 0.183612691994785 no 862 0.215215251945382 767 NA FT PLASMA MEMBRANE Putative protein of unknown function; YDR524C-B has a paralog, YCL048W-A, that arose from the whole genome duplication biological_process molecular_function cellular_component
YGR199W YGR199W PMT6 hom Verified 0.901204004190219 0.183739931181441 no 863 0.175404027264399 584 NA FT CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Protein O-mannosyltransferase, transfers mannose from dolichyl phosphate-D-mannose to protein serine/threonine residues of secretory proteins; reaction is essential for cell wall rigidity; member of a family of mannosyltransferases protein O-linked glycosylation|protein O-linked mannosylation dolichyl-phosphate-mannose-protein mannosyltransferase activity integral to membrane
YAL037C-A_p YAL037C-A YAL037C-A hom Uncharacterized 0.90071203827079 0.183870723175745 no 864 0.186498125048696 647 NA Putative protein of unknown function biological_process molecular_function cellular_component
YML094C-A_d YML094C-A YML094C-A hom Dubious 0.900171500342517 0.184014495157094 no 865 0.188543337890142 694 NA FF Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene GIM5/YML094W; deletion confers sensitivity to GSAO Unknown Unknown Unknown
YNL081C YNL081C SWS2 hom Verified 0.899588044334227 0.184169760992939 no 866 0.232486512265302 791 NA FF|FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Putative mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S13 ribosomal protein; participates in controlling sporulation efficiency regulation of sporulation resulting in formation of a cellular spore|mitochondrial translation structural constituent of ribosome mitochondrial small ribosomal subunit|cytoplasm
YJR019C YJR019C TES1 hom Verified 0.899308017791499 0.18424430893828 no 867 0.179621777392113 579 NA FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM MITOCHONDRION Peroxisomal acyl-CoA thioesterase likely to be involved in fatty acid oxidation rather than fatty acid synthesis; conserved protein also found in human peroxisomes; TES1 mRNA levels increase during growth on fatty acids fatty acid beta-oxidation|fatty acid oxidation acyl-CoA hydrolase activity mitochondrion|peroxisome
YLR236C_d YLR236C YLR236C hom Dubious 0.899185970733289 0.184276805866928 no 868 0.167754854591777 562 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YPL140C YPL140C MKK2 hom Verified 0.898629423061124 0.184425040558531 no 869 0.1833480451526 605 NA FT SIGNALING|PROTEIN PHOSPHORYLATION|PEROXISOME ORGANIZATION MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk1p; MKK2 has a paralog, MKK1, that arose from the whole genome duplication signal transduction|peroxisome degradation|protein phosphorylation MAP kinase kinase activity intracellular
YKL020C YKL020C SPT23 hom Verified 0.898068157912086 0.184574606835661 no 870 0.168161031576502 611 NA FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|LIPID METABOLISM|GENE SILENCING ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM ER membrane protein involved in regulation of OLE1 transcription, acts with homolog Mga2p; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting cellular response to cold|positive regulation of unsaturated fatty acid biosynthetic process by positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|chromatin silencing at silent mating-type cassette DNA binding integral to endoplasmic reticulum membrane|nucleus
YLR294C_d YLR294C YLR294C hom Dubious 0.897996040268799 0.184593830256315 no 871 0.188941349782276 638 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene ATP14 Unknown Unknown Unknown
YIR026C YIR026C YVH1 hom Verified 0.897669652177317 0.184680846663922 no 872 0.189222105092263 629 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RIBOSOME BIOGENESIS|SIGNALING|CELL WALL ORG/BIOGENESIS NUCLEUS Protein phosphatase involved in vegetative growth at low temperatures, sporulation, and glycogen accumulation; mutants are defective in 60S ribosome assembly; member of the dual-specificity family of protein phosphatases meiosis|ascospore wall assembly|ribosomal large subunit assembly|cAMP-mediated signaling|protein dephosphorylation protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity nucleus|preribosome, large subunit precursor|cytoplasm
YMR207C YMR207C HFA1 hom Verified 0.89523881842015 0.185329718947567 no 873 0.172333482496663 636 NA FT KETONE METABOLISM|LIPID METABOLISM MITOCHONDRION Mitochondrial acetyl-coenzyme A carboxylase; catalyzes the production of malonyl-CoA in mitochondrial fatty acid biosynthesis; relocalizes from mitochondrion to cytoplasm upon DNA replication stress fatty acid biosynthetic process acetyl-CoA carboxylase activity mitochondrion
YLR435W YLR435W TSR2 hom Verified 0.894776742418279 0.185453222680932 no 874 0.188848849889024 674 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Protein with a potential role in pre-rRNA processing maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) molecular_function nucleus|cytoplasm
YPR098C YPR098C YPR098C hom Verified 0.894747635820723 0.185461004006054 no 875 0.207298846149945 698 NA FT MITOCHONDRION Protein of unknown function, localized to the mitochondrial outer membrane biological_process molecular_function mitochondrial outer membrane|mitochondrion
YPR092W_d YPR092W YPR092W hom Dubious 0.894670141379294 0.185481722271075 no 876 0.195624486084676 650 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YOR227W YOR227W HER1 hom Verified 0.893406828085332 0.185819673703579 no 877 0.194520684039877 656 NA FT MITOCHONDRION Protein of unknown function required for proliferation or remodeling of the ER that is caused by overexpression of Hmg2p; may interact with ribosomes, based on co-purification experiments; HER1 has a paralog, GIP3, that arose from the whole genome duplication endoplasmic reticulum organization molecular_function mitochondrion|ribosome|cytoplasm
YLR055C YLR055C SPT8 hom Verified 0.893098453964543 0.18590222542716 no 878 0.194122970153098 683 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION NUCLEUS HISTONE ACETYLTRANSFERASE Subunit of the SAGA transcriptional regulatory complex but not present in SAGA-like complex SLIK/SALSA, required for SAGA-mediated inhibition at some promoters histone acetylation|negative regulation of transcription from RNA polymerase II promoter|chromatin modification|positive regulation of transcription from RNA polymerase II promoter TBP-class protein binding|transcription cofactor activity nucleus|SAGA complex
YGL162W YGL162W SUT1 hom Verified 0.891214321319283 0.186407101392265 no 879 0.178402242096098 579 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Transcription factor of the Zn2Cys6 family involved in sterol uptake; involved in induction of hypoxic gene expression; relocalizes from nucleus to cytoplasm upon DNA replication stress positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter RNA polymerase II repressing transcription factor binding nucleus
YJL218W_p YJL218W YJL218W hom Uncharacterized 0.890743392852879 0.186533424883739 no 880 0.188002217579186 682 NA Putative acetyltransferase; similar to bacterial galactoside O-acetyltransferases; induced by oleate in an OAF1/PIP2-dependent manner; promoter contains an oleate response element consensus sequence; non-essential gene biological_process acetyltransferase activity cellular_component
YFR032C_p YFR032C RRT5 hom Uncharacterized 0.889790437530099 0.186789211071323 no 881 0.182056792135533 684 NA Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; expressed at high levels during sporulation biological_process molecular_function cellular_component
YIL041W YIL041W GVP36 hom Verified 0.889695758329398 0.186814636108879 no 882 0.205783754431384 675 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION ENDOMEMBRANE SYSTEM|GOLGI APPARATUS BAR domain-containing protein that localizes to both early and late Golgi vesicles; required for adaptation to varying nutrient concentrations, fluid-phase endocytosis, polarization of the actin cytoskeleton, and vacuole biogenesis vacuole organization|endocytosis|establishment or maintenance of actin cytoskeleton polarity molecular_function integral to Golgi membrane|cytoplasm
YGR155W YGR155W CYS4 hom Verified 0.888796617913428 0.187056196928331 no 883 0.188514960339939 668 NA FT KETONE METABOLISM|CELL CYCLE|AMINO ACID METABOLISM MITOCHONDRION Cystathionine beta-synthase, catalyzes synthesis of cystathionine from serine and homocysteine, the first committed step in cysteine biosynthesis; responsible for hydrogen sulfide generation; advances passage through START by promoting cell growth which requires catalytic activity, and reducing critical cell size independent of catalytic activity; mutations in human ortholog cause homocystinuria cysteine biosynthetic process from serine|hydrogen sulfide biosynthetic process|cysteine biosynthetic process via cystathionine|transsulfuration|traversing start control point of mitotic cell cycle cystathionine beta-synthase activity mitochondrion|cytoplasm
YCR091W YCR091W KIN82 hom Verified 0.888680647709128 0.187087367255394 no 884 0.165720963341804 597 NA FT MEMBRANE ORGANIZATION|PROTEIN PHOSPHORYLATION Putative serine/threonine protein kinase implicated in the regulation of phospholipid asymmetry through the activation of phospholipid translocases (flippases) Lem3p-Dnf1p/Dnf2p; similar to Fpk1p phospholipid translocation|protein phosphorylation|response to pheromone protein kinase activity cellular_component
YCL061C YCL061C MRC1 hom Verified 0.888361131376192 0.187173263075957 no 885 0.210533165138787 748 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION|GENE SILENCING NUCLEUS|CHROMOSOME S-phase checkpoint protein required for DNA replication; interacts with and stabilizes Pol2p at stalled replication forks during stress, where it forms a pausing complex with Tof1p and is phosphorylated by Mec1p; protects uncapped telomeres maintenance of DNA repeat elements|intra-S DNA damage checkpoint|DNA repair|DNA replication checkpoint|telomere maintenance|replication fork protection|DNA replication|mitotic sister chromatid cohesion|chromatin silencing at silent mating-type cassette|chromatin silencing at telomere molecular_function nuclear chromosome|replication fork protection complex|nucleus|nuclear replication fork
YFR036W YFR036W CDC26 hom Verified 0.887699760158611 0.187351137480506 no 886 0.234929040584078 864 NA FF|FT CELL CYCLE|CHROMATIN ORGANIZATION|CELL DIVISION|PROTEOLYSIS NUCLEUS UBIQUITIN LIGASE COMPLEX Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition chromatin assembly|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination ubiquitin-protein ligase activity anaphase-promoting complex
YDR346C YDR346C SVF1 hom Verified 0.886955871100907 0.187551329708201 no 887 0.215733335477841 711 NA FT RESPONSE TO OXIDATIVE STRESS NUCLEUS Protein with a potential role in cell survival pathways, required for the diauxic growth shift; expression in mammalian cells increases survival under conditions inducing apoptosis; mutant has increased aneuploidy tolerance cellular response to oxidative stress molecular_function nucleus|cytoplasm
YLR341W YLR341W SPO77 hom Verified 0.886332717587425 0.18771913180831 no 888 0.192202252948206 634 NA FT CELL WALL ORG/BIOGENESIS Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis ascospore wall assembly|ascospore formation molecular_function intracellular
YDR385W YDR385W EFT2 hom Verified 0.88469342061186 0.188161002594467 no 889 0.177659475890065 638 NA FT TRANSLATION|NUCLEOTIDE METABOLISM RIBOSOME Elongation factor 2 (EF-2), also encoded by EFT1; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin; EFT2 has a paralog, EFT1, that arose from the whole genome duplication translational elongation|positive regulation of translational elongation translation elongation factor activity ribosome
YER053C-A YER053C-A YER053C-A hom Verified 0.884655584354652 0.188171208890698 no 890 0.163246381444204 554 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; protein abundance increases in response to DNA replication stress biological_process molecular_function endoplasmic reticulum
YDR199W_d YDR199W YDR199W hom Dubious 0.883545690182032 0.188470753824879 no 891 0.213842147739165 743 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VPS64; computationally predicted to have thiol-disulfide oxidoreductase activity Unknown Unknown Unknown
YNL307C YNL307C MCK1 hom Verified 0.883184924864685 0.188568182637934 no 892 0.216362606644828 777 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION|CHROMOSOME SEGREGATION Protein serine/threonine/tyrosine (dual-specificity) kinase; involved in control of chromosome segregation and in regulating entry into meiosis; interacts with Clb2p and Mih1p; inhibits Clb2p-Cdk1 activity; related to mammalian glycogen synthase kinases of the GSK-3 family meiosis|double-strand break repair via nonhomologous end joining|ascospore formation|protein phosphorylation|response to stress|mitotic sister chromatid segregation protein serine/threonine/tyrosine kinase activity|protein serine/threonine kinase activity|protein kinase activity cellular_component
YDR520C_p YDR520C URC2 hom Uncharacterized 0.882486035556911 0.188757014045113 no 893 0.224701189538489 719 NA FT TRANSCRIPTION FROM RNA POL II|NUCLEOTIDE METABOLISM NUCLEUS Putative Zn(II)2Cys6 motif containing transcription factor; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; similar to S. kluyveri Urc2p involved in uracil catabolism uracil catabolic process sequence-specific DNA binding nucleus|cytoplasm
YKL160W YKL160W ELF1 hom Verified 0.882025597816574 0.18888148239281 no 894 0.178987450906726 618 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION NUCLEUS Transcription elongation factor that contains a conserved zinc finger domain; implicated in the maintenance of proper chromatin structure in actively transcribed regions; deletion inhibits Brome mosaic virus (BMV) gene expression regulation of transcription by chromatin organization|transcription elongation from RNA polymerase II promoter RNA polymerase II core binding transcription elongation factor complex|nucleus
YOL052C YOL052C SPE2 hom Verified 0.881967075491187 0.188897306127522 no 895 0.203899907263395 647 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM NUCLEUS S-adenosylmethionine decarboxylase, required for the biosynthesis of spermidine and spermine; cells lacking Spe2p require spermine or spermidine for growth in the presence of oxygen but not when grown anaerobically spermidine biosynthetic process|spermine biosynthetic process|pantothenate biosynthetic process adenosylmethionine decarboxylase activity nucleus|cytoplasm
YDL243C YDL243C AAD4 hom Verified 0.880909062306472 0.189183521047197 no 896 0.179983817595146 602 NA FT OXIDATION-REDUCTION PROCESS Putative aryl-alcohol dehydrogenase; involved in oxidative stress response; similar to P. chrysosporium aryl-alcohol dehydrogenase; expression induced in cells treated with the mycotoxin patulin cellular aldehyde metabolic process aryl-alcohol dehydrogenase (NAD+) activity cellular_component
YBR300C_d YBR300C YBR300C hom Dubious 0.880367323745901 0.189330176089054 no 897 0.202284779970201 715 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR301W; YBR300C is not an essential gene Unknown Unknown Unknown
YBR048W YBR048W RPS11B hom Verified 0.878942157150483 0.189716319646726 no 898 0.200143472343044 697 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S11 and bacterial S17; RPS11B has a paralog, RPS11A, that arose from the whole genome duplication cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|ribosomal small subunit assembly structural constituent of ribosome cytosolic small ribosomal subunit|90S preribosome
YER047C YER047C SAP1 hom Verified 0.878445472247482 0.189851008305206 no 899 0.206722519238438 715 NA Putative ATPase of the AAA family, interacts with the Sin1p transcriptional repressor in the two-hybrid system biological_process ATPase activity cytoplasm
YDL090C YDL090C RAM1 hom Verified 0.877784361609914 0.190030376341531 no 900 0.25663222381228 890 NA FF|FT PROTEIN PRENYLATION Beta subunit of the CAAX farnesyltransferase (FTase) that prenylates the a-factor mating pheromone and Ras proteins; required for the membrane localization of Ras proteins and a-factor; homolog of the mammalian FTase beta subunit protein farnesylation protein farnesyltransferase activity protein farnesyltransferase complex
YLR386W YLR386W VAC14 hom Verified 0.877309926605186 0.190159160987971 no 901 0.229182706047668 803 NA FT PROTEIN LOCALIZATION|LIPID METABOLISM Protein involved in regulated synthesis of PtdIns(3,5)P(2), in control of trafficking of some proteins to the vacuole lumen via the MVB, and in maintenance of vacuole size and acidity; interacts with Fig4p; activator of Fab1p phosphatidylinositol biosynthetic process|positive regulation of kinase activity protein binding, bridging fungal-type vacuole membrane|PAS complex|extrinsic to vacuolar membrane
YDL178W YDL178W DLD2 hom Verified 0.877172185258763 0.190196560705687 no 902 0.233253804440199 780 NA FT KETONE METABOLISM|OXIDATION-REDUCTION PROCESS MITOCHONDRION D-lactate dehydrogenase, located in the mitochondrial matrix lactate metabolic process actin binding|D-lactate dehydrogenase (cytochrome) activity mitochondrion|mitochondrial matrix
YFL054C_p YFL054C YFL054C hom Uncharacterized 0.876738870700765 0.190314244332147 no 903 0.180310601689877 603 NA Putative channel-like protein; similar to Fps1p; mediates passive diffusion of glycerol in the presence of ethanol water transport|transmembrane transport water channel activity|glycerol transmembrane transporter activity|transporter activity integral to membrane
YGR100W YGR100W MDR1 hom Verified 0.876731893700215 0.190316139577124 no 904 0.200081151271259 675 NA FT PROTEIN LOCALIZATION|SIGNALING|NUCLEOTIDE METABOLISM Cytoplasmic GTPase-activating protein for Ypt/Rab transport GTPases Ypt6p, Ypt31p and Sec4p; involved in recycling of internalized proteins and regulation of Golgi secretory function intracellular protein transport Rab GTPase activator activity cytoplasm
YDR136C_d YDR136C VPS61 hom Dubious 0.876727387170804 0.19031736374504 no 905 0.292014167639215 967 NA FF Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 4% of ORF overlaps the verified gene RGP1; deletion causes a vacuolar protein sorting defect Unknown Unknown Unknown
YDR003W-A_p YDR003W-A YDR003W-A hom Uncharacterized 0.876484129281641 0.19038345026496 no 906 0.209487688505729 688 NA Putative protein of unknown function; identified by expression profiling and mass spectrometry biological_process molecular_function cellular_component
YGL002W YGL002W ERP6 hom Verified 0.874274863891296 0.190984292336845 no 907 0.203925868785539 669 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION Member of the p24 family involved in ER to Golgi transport; similar to Emp24p and Erv25p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; ERP6 has a paralog, ERP1, that arose from the whole genome duplication ER to Golgi vesicle-mediated transport molecular_function mitochondrion|integral to membrane
YBL070C_d YBL070C YBL070C hom Dubious 0.873677086976048 0.191147066232301 no 908 0.200309528860524 652 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YLR354C YLR354C TAL1 hom Verified 0.872471484450929 0.191475608940762 no 909 0.22355857635461 731 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS NUCLEUS Transaldolase, enzyme in the non-oxidative pentose phosphate pathway; converts sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate to erythrose 4-phosphate and fructose 6-phosphate pentose-phosphate shunt sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity nucleus|cytoplasm
YPL052W YPL052W OAZ1 hom Verified 0.872224099804792 0.191543067301402 no 910 0.18123000106696 627 NA FT TRANSLATION|PROTEOLYSIS Regulator of ornithine decarboxylase (Spe1p), antizyme that binds to Spe1p to stimulate ubiquitin-independent degradation by the proteasome; binding of polyamines to nascent Oaz1p during translation stimulates +1 ribosomal frameshifting, allowing translation of full-length Oaz1p Unknown|regulation of proteasomal protein catabolic process ornithine decarboxylase inhibitor activity cytoplasm
YLR122C_d YLR122C YLR122C hom Dubious 0.87007464449971 0.192129806572132 no 911 0.197544692901198 648 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR123C Unknown Unknown Unknown
YGL066W YGL066W SGF73 hom Verified 0.870001034082841 0.192149919546446 no 912 0.223471513287792 742 NA FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|CHROMATIN ORGANIZATION|RNA LOCALIZATION NUCLEUS HISTONE ACETYLTRANSFERASE SAGA complex subunit; has a role in anchoring the deubiquitination module into SAGA and SLIK complexes; involved in preinitiation complex assembly at promoters; human ortholog ataxin-7 is associated with spinocerebellar ataxia diseases; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay histone deubiquitination|mRNA export from nucleus|histone acetylation|positive regulation of RNA polymerase II transcriptional preinitiation complex assembly|protein complex assembly|chromatin modification histone acetyltransferase activity|enzyme activator activity|structural molecule activity DUBm complex|SLIK (SAGA-like) complex|SAGA complex
YJR034W YJR034W PET191 hom Verified 0.869835928355492 0.192195036966461 no 913 0.20294247200188 708 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Protein required for assembly of cytochrome c oxidase; exists as an oligomer; described as both an integral mitochondrial inner membrane protein facing the intermembrane space (IMS) and as a soluble IMS protein; contains a twin Cx9C motif; imported into the IMS via the MIA import machinery mitochondrial respiratory chain complex IV assembly molecular_function mitochondrion|integral to mitochondrial inner membrane
YCR101C_p YCR101C YCR101C hom Uncharacterized 0.86860327595398 0.192532081019687 no 914 0.193615874497814 697 NA Putative protein of unknown function; localizes to the membrane fraction; YCR101C is not an essential gene biological_process molecular_function integral to membrane|membrane
YKR042W YKR042W UTH1 hom Verified 0.867664500491328 0.192789012532049 no 915 0.181096319944259 679 NA FT CELL CYCLE|CHROMATIN ORGANIZATION|CELL WALL ORG/BIOGENESIS|CELL DIVISION|GENE SILENCING MITOCHONDRION Protein involved in cell wall biogenesis; required for mitochondrial autophagy; mitochondrial outer membrane and cell wall localized SUN family member; involved in the oxidative stress response, life span during starvation, and cell death; UTH1 has a paralog, NCA3, that arose from the whole genome duplication mitochondrion degradation|fungal-type cell wall biogenesis|negative regulation of chromatin silencing involved in replicative cell aging molecular_function mitochondrial outer membrane|fungal-type cell wall
YNR036C YNR036C MRPS12 hom Verified 0.866221244810685 0.19318442253272 no 916 0.206268008015645 712 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial protein; may interact with ribosomes based on co-purification experiments; similar to E. coli and human mitochondrial S12 ribosomal proteins mitochondrial translation structural constituent of ribosome mitochondrion|ribosome|mitochondrial small ribosomal subunit
YGR037C YGR037C ACB1 hom Verified 0.864313744784708 0.193707780817622 no 917 0.276507642761273 969 NA FF|FT KETONE METABOLISM|LIPID METABOLISM NUCLEUS Acyl-CoA-binding protein, transports newly synthesized acyl-CoA esters from fatty acid synthetase (Fas1p-Fas2p) to acyl-CoA-consuming processes; subject to starvation-induced, Grh1p-mediated unconventional secretion; protein abundance increases in response to DNA replication stress long-chain fatty acid transport|chronological cell aging|fatty acid metabolic process long-chain fatty acid transporter activity|fatty-acyl-CoA binding extracellular region|nucleus|cytoplasm
YLR412W YLR412W BER1 hom Verified 0.862826547398419 0.194116420348031 no 918 0.186250448734251 649 NA FT CYTOSKELETON Protein involved in microtubule-related processes, N-acetylation; GFP-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YLR412W is not an essential gene; similar to Arabidopsis SRR1 gene biological_process molecular_function cytoplasm
YGR014W YGR014W MSB2 hom Verified 0.861218600677869 0.194558828685155 no 919 0.228649254408546 780 NA FT SIGNALING SITE OF POLARIZED GROWTH|PLASMA MEMBRANE Mucin family member involved in signaling; functions in the Cdc42p- and MAP kinase-dependent filamentous growth signaling pathway; is processed into secreted and cell-associated forms by the aspartyl protease, Yps1p; also functions as an osmosensor in parallel to the Sho1p-mediated pathway; potential Cdc28p substrate signal transduction involved in filamentous growth|osmosensory signaling pathway via Sho1 osmosensor|establishment of cell polarity|hyperosmotic response|response to osmotic stress osmosensor activity site of polarized growth|integral to plasma membrane
YCR048W YCR048W ARE1 hom Verified 0.861007249846947 0.194617025067267 no 920 0.160701114941549 549 NA FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Acyl-CoA:sterol acyltransferase; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the absence of oxygen; ARE1 has a paralog, ARE2, that arose from the whole genome duplication sterol metabolic process ergosterol O-acyltransferase activity|lanosterol O-acyltransferase activity integral to membrane|endoplasmic reticulum
YNL025C YNL025C SSN8 hom Verified 0.860808414979157 0.194671784792818 no 921 0.211849012738352 739 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS NUCLEUS Cyclin-like component of the RNA polymerase II holoenzyme, involved in phosphorylation of the RNA polymerase II C-terminal domain; involved in glucose repression and telomere maintenance positive regulation of transcription from RNA polymerase II promoter during meiosis|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription by galactose|positive regulation of transcription from RNA polymerase II promoter cyclin-dependent protein kinase regulator activity mediator complex
YLR113W YLR113W HOG1 hom Verified 0.860773380580701 0.194681434343703 no 922 0.225152599099322 731 NA FT TRANSCRIPTION FROM RNA POL II|SIGNALING|PROTEIN PHOSPHORYLATION NUCLEUS Mitogen-activated protein kinase involved in osmoregulation; controls global reallocation of RNA Pol II in response to osmotic shock; acts via three independent osmosensors; mitophagy-specific regulator; mediates the recruitment and activation of RNA Pol II at Hot1p-dependent promoters; localization regulated by Ptp2p and Ptp3p; protein abundance increases in response to DNA replication stress negative regulation of transcription from RNA polymerase II promoter by pheromones|protein phosphorylation|hyperosmotic response|response to arsenic-containing substance|osmosensory signaling pathway|positive regulation of transcription from RNA polymerase II promoter|cellular response to heat MAP kinase activity nucleus|cytoplasm
YKR029C YKR029C SET3 hom Verified 0.860725638330497 0.19469458449629 no 923 0.199726501085546 686 NA FT CELL CYCLE|CHROMATIN ORGANIZATION NUCLEUS|CHROMOSOME Defining member of the SET3 histone deacetylase complex which is a meiosis-specific repressor of sporulation genes; necessary for efficient transcription by RNAPII; one of two yeast proteins that contains both SET and PHD domains; SET3 has a paralog, SET4, that arose from the whole genome duplication negative regulation of meiosis|regulation of transcription, DNA-dependent|histone deacetylation methylated histone residue binding Rpd3L-Expanded complex|Set3 complex
YBR268W YBR268W MRPL37 hom Verified 0.860505929047598 0.194755108311887 no 924 0.239936351209235 832 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YOR338W_p YOR338W YOR338W hom Uncharacterized 0.859703636859153 0.194976214750277 no 925 0.17259082246844 619 NA FT TRANSCRIPTION FROM RNA POL II Putative protein of unknown function; YOR338W transcription is regulated by Azf1p and its transcript is a specific target of the G protein effector Scp160p; identified as being required for sporulation in a high-throughput mutant screen; YOR338W has a paralog, FUN19, that arose from the whole genome duplication ascospore formation|positive regulation of transcription from RNA polymerase II promoter molecular_function cellular_component
YOR346W YOR346W REV1 hom Verified 0.85965097615608 0.194990733028696 no 926 0.171280787713896 551 NA FT RESPONSE TO DNA DAMAGE NUCLEUS|MITOCHONDRION|CHROMOSOME Deoxycytidyl transferase; involved in repair of abasic sites and adducted guanines in damaged DNA by translesion synthesis (TLS); forms a complex with the subunits of DNA polymerase zeta, Rev3p and Rev7p; relocalizes from nucleus to cytoplasm upon DNA replication stress error-prone translesion synthesis|error-free translesion synthesis deoxycytidyl transferase activity|DNA-directed DNA polymerase activity nuclear chromatin|mitochondrion|replication fork
YCL074W YCL074W YCL074W hom pseudogene 0.859085302915295 0.195146727608544 no 927 0.190202750544608 634 NA FT NUCLEUS Pseudogene: encodes fragment of Ty Pol protein transposition, RNA-mediated ribonuclease activity|peptidase activity|RNA binding|RNA-directed DNA polymerase activity|DNA-directed DNA polymerase activity retrotransposon nucleocapsid
YMR070W YMR070W MOT3 hom Verified 0.85884825060939 0.195212121596123 no 928 0.22857424069346 799 NA FT TRANSCRIPTION FROM RNA POL II|LIPID METABOLISM NUCLEUS Transcriptional repressor and activator with two C2-H2 zinc fingers; involved in repression of a subset of hypoxic genes by Rox1p, repression of several DAN/TIR genes during aerobic growth, and repression of ergosterol biosynthetic genes in response to hyperosmotic stress; contributes to recruitment of the Tup1p-Cyc8p general repressor to promoters; involved in positive transcriptional regulation of CWP2 and other genes; can form the [MOT3+] prion cellular hyperosmotic response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of ergosterol biosynthetic process|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II repressing transcription factor binding|RNA polymerase II activating transcription factor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding nucleus
YJL209W YJL209W CBP1 hom Verified 0.857529054633045 0.19557628230828 no 929 0.187684433693995 659 NA FT RNA PROCESSING|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Mitochondrial protein, regulator of COB mRNA stability and translation; interacts with the 5'-untranslated region of the COB mRNA; found in a complex at the inner membrane along with Pet309p; localizes to mitochondrial foci upon DNA replication stress mitochondrial mRNA catabolic process|aerobic respiration mRNA binding mitochondrion|extrinsic to mitochondrial inner membrane
YMR075C-A_d YMR075C-A YMR075C-A hom Dubious 0.857488980519844 0.195587351117569 no 930 0.189741778406048 628 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF RCO1/YMR075W Unknown Unknown Unknown
YKL208W YKL208W CBT1 hom Verified 0.855195603736542 0.1962214347994 no 931 0.194932640811539 657 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS MITOCHONDRION Protein involved in 5' end processing of mitochondrial COB, 15S_rRNA, and RPM1 transcripts; may also have a role in 3' end processing of the COB pre-mRNA; displays genetic interaction with cell cycle-regulated kinase Dbf2p cytochrome complex assembly|mRNA processing|mRNA stabilization molecular_function mitochondrion
YJL179W YJL179W PFD1 hom Verified 0.854199162145425 0.196497323678129 no 932 0.203764853963223 700 NA FT CYTOSKELETON ORGANIZATION Subunit of heterohexameric prefoldin, which binds cytosolic chaperonin and transfers target proteins to it; involved in the biogenesis of actin and of alpha- and gamma-tubulin protein folding|cytoskeleton organization unfolded protein binding prefoldin complex
YJL198W YJL198W PHO90 hom Verified 0.853883443510506 0.196584787007562 no 933 0.201020427999138 660 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS Low-affinity phosphate transporter; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth; PHO90 has a paralog, PHO87, that arose from the whole genome duplication phosphate ion transport phosphate ion transmembrane transporter activity integral to membrane|membrane
YOL145C YOL145C CTR9 hom Verified 0.853671374154011 0.196643549684582 no 934 0.247157021256405 879 NA FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION|GENE SILENCING NUCLEUS|CHROMOSOME RNA POL II, HOLOENZYME Component of the Paf1p complex involved in transcription elongation; binds to and modulates the activity of RNA polymerases I and II; required for expression of a subset of genes, including cyclin genes; involved in SER3 repression by helping to maintain SRG1 transcription-dependent nucleosome occupancy; contains TPR repeats transcription elongation from RNA polymerase I promoter|mRNA 3'-end processing|regulation of chromatin silencing at telomere|snoRNA transcription from an RNA polymerase II promoter|regulation of transcription by chromatin organization|transcription from RNA polymerase I promoter|regulation of histone H3-K4 methylation|regulation of transcription-coupled nucleotide-excision repair|regulation of transcription initiation from RNA polymerase II promoter|snoRNA 3'-end processing|Unknown|regulation of transcription involved in G1 phase of mitotic cell cycle|transcription elongation from RNA polymerase II promoter RNA polymerase II core binding|triplex DNA binding|RNA polymerase II transcription factor binding transcription factor activity transcriptionally active chromatin|nucleus|Cdc73/Paf1 complex
YKL183W YKL183W LOT5 hom Verified 0.853149688520694 0.196788149765259 no 935 0.178072396414045 589 NA FT NUCLEUS Protein of unknown function; gene expression increases in cultures shifted to a lower temperature; protein abundance increases in response to DNA replication stress biological_process molecular_function nucleus|cytoplasm
YNL065W YNL065W AQR1 hom Verified 0.852617714608214 0.196935667825535 no 936 0.179451835847211 623 NA FT PLASMA MEMBRANE Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; confers resistance to short-chain monocarboxylic acids and quinidine; involved in the excretion of excess amino acids; AQR1 has a paralog, QDR1, that arose from the whole genome duplication; relocalizes from plasma membrane to cytoplasm upon DNA replication stress monocarboxylic acid transport|drug transmembrane transport|amino acid export monocarboxylic acid transmembrane transporter activity|drug transmembrane transporter activity integral to membrane|plasma membrane
YDR165W YDR165W TRM82 hom Verified 0.851670210187224 0.197198579567276 no 937 0.219724363856757 708 NA FT RNA PROCESSING NUCLEUS Catalytic subunit of a tRNA methyltransferase complex; Trm8p and Trm82p comprise an enzyme that catalyzes a methyl-transfer from S-adenosyl-l-methionine to the N(7) atom of guanine at position 46 in tRNA; Trm8 lacks catalytic activity if not bound to Trm82p tRNA methylation tRNA (guanine-N7-)-methyltransferase activity tRNA methyltransferase complex|nucleus
YOR349W YOR349W CIN1 hom Verified 0.851641580261974 0.197206527048832 no 938 0.198745132984066 754 NA FF|FT PROTEIN COMPLEX ORG/BIOGENESIS Tubulin folding factor D involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl protein folding|tubulin complex assembly|tubulin complex biogenesis beta-tubulin binding cellular_component
YLR065C YLR065C ENV10 hom Verified 0.851033972394654 0.197375240745658 no 939 0.231263775432507 842 NA FF|FT VACUOLAR PROTEIN PROCESSING Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing; YLR065C is not an essential gene vacuolar protein processing molecular_function integral to membrane
YPL002C YPL002C SNF8 hom Verified 0.850916922443441 0.197407751880387 no 940 0.217823758899686 776 NA FF|FT PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|PROTEOLYSIS|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; appears to be functionally related to SNF7; involved in glucose derepression negative regulation of transcription from RNA polymerase II promoter by glucose|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|protein targeting to vacuole molecular_function ESCRT II complex
YJL020C YJL020C BBC1 hom Verified 0.85080983859249 0.197437497723705 no 941 0.1728119026981 583 NA FT CYTOSKELETON ORGANIZATION CYTOSKELETON Protein possibly involved in assembly of actin patches; interacts with an actin assembly factor Las17p and with the SH3 domains of Type I myosins Myo3p and Myo5p; localized predominantly to cortical actin patches actin cytoskeleton organization myosin I binding actin cortical patch
YPL213W YPL213W LEA1 hom Verified 0.850401324418606 0.197551000029072 no 942 0.196629134050238 712 NA FT RNA PROCESSING NUCLEUS Component of U2 snRNP; disruption causes reduced U2 snRNP levels; physically interacts with Msl1p; putative homolog of human U2A' snRNP protein mRNA splicing, via spliceosome molecular_function U2 snRNP|U2-type prespliceosome|cytoplasm
YIR002C YIR002C MPH1 hom Verified 0.849254536185046 0.197869836445385 no 943 0.199998031336248 697 NA FT RESPONSE TO DNA DAMAGE NUCLEUS 3'-5' DNA helicase involved in error-free bypass of DNA lesions; binds to flap DNA in an error-free bypass pathway and stimulates the activity of Rad27p and Dna2p; also involved in interstrand cross-link repair mutations confer a mutator phenotype; similarity to FANCM, a human Fanconi anemia complementation group protein that along with the MHF complex is involved in stabilizing and remodeling blocked replication forks; member of the SF2 DExD/H superfamily of helicases negative regulation of strand invasion|recombinational repair|DNA replication, Okazaki fragment processing flap-structured DNA binding|3'-5' DNA helicase activity nucleus
YEL045C_d YEL045C YEL045C hom Dubious 0.848924845040349 0.19796155650475 no 944 0.23497511833236 762 NA Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; deletion gives MMS sensitivity, growth defect under alkaline conditions, less than optimal growth upon citric acid stress Unknown Unknown Unknown
YDL061C YDL061C RPS29B hom Verified 0.848178555641529 0.198169269007502 no 945 0.183589981104155 616 NA FT TRANSLATION RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S29 and bacterial S14; RPS29B has a paralog, RPS29A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic small ribosomal subunit
YEL017C-A YEL017C-A PMP2 hom Verified 0.847934872822969 0.198237121005053 no 946 0.214063415091093 742 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE Proteolipid associated with plasma membrane H(+)-ATPase (Pma1p); regulates plasma membrane H(+)-ATPase activity; protein abundance increases in response to DNA replication stress; PMP2 has a paralog, PMP1, that arose from the whole genome duplication cation transport molecular_function membrane
YKL138C YKL138C MRPL31 hom Verified 0.847633827766359 0.198320964529437 no 947 0.216923367078432 751 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit mitochondrial translation structural constituent of ribosome mitochondrial large ribosomal subunit
YPL180W YPL180W TCO89 hom Verified 0.847072237707158 0.198477429168152 no 948 0.219670523911551 776 NA FT SIGNALING|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM PLASMA MEMBRANE Subunit of TORC1 (Tor1p or Tor2p-Kog1p-Lst8p-Tco89p), a complex that regulates growth in response to nutrient availability; cooperates with Ssd1p in the maintenance of cellular integrity; deletion strains are hypersensitive to rapamycin TOR signaling cascade|fungal-type cell wall organization|response to salt stress|regulation of cell growth|glycerol metabolic process molecular_function TORC1 complex|fungal-type vacuole membrane|extrinsic to internal side of plasma membrane|extrinsic to vacuolar membrane
YDR323C YDR323C PEP7 hom Verified 0.846533197432214 0.198627681235371 no 949 0.263338593543375 904 NA FF|FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT Multivalent adaptor protein that facilitates vesicle-mediated vacuolar protein sorting by ensuring high-fidelity vesicle docking and fusion, which are essential for targeting of vesicles to the endosome; required for vacuole inheritance Golgi to vacuole transport|vacuole inheritance|vesicle fusion|vesicle docking involved in exocytosis|Golgi to endosome transport phosphatidylinositol-3-phosphate binding external side of endosome membrane|cytoplasm
YHR006W YHR006W STP2 hom Verified 0.845605591368877 0.198886402656434 no 950 0.17452043420087 599 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS|PLASMA MEMBRANE Transcription factor; activated by proteolytic processing in response to signals from the SPS sensor system for external amino acids; activates transcription of amino acid permease genes; STP2 has a paralog, STP1, that arose from the whole genome duplication positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus|cytoplasm
YPR050C_d YPR050C YPR050C hom Dubious 0.844032946867923 0.19932549753561 no 951 0.236675749667494 807 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene MAK3/YPR051W Unknown Unknown Unknown
YLR062C_d YLR062C BUD28 hom Dubious 0.843171065635284 0.199566389069517 no 952 0.221195485304792 727 NA Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene RPL22A; diploid mutant displays a weak budding pattern phenotype in a systematic assay Unknown Unknown Unknown
YGR010W YGR010W NMA2 hom Verified 0.84289518429805 0.199643533537897 no 953 0.2059950212542 636 NA FT NUCLEOTIDE METABOLISM|COFACTOR METABOLISM NUCLEUS Nicotinic acid mononucleotide adenylyltransferase; catalyzes the transfer of the adenylyl moiety of ATP to nicotinamide mononucleotide to form NAD; involved in de novo and salvage synthesis of NAD(+); NMA2 has a paralog, NMA1, that arose from the whole genome duplication NAD biosynthetic process nicotinamide-nucleotide adenylyltransferase activity nucleus
YAL004W_d YAL004W YAL004W hom Dubious 0.842341204543749 0.199798496617711 no 954 0.221531563568691 732 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene SSA1/YAL005C Unknown Unknown Unknown
YMR135W-A_d YMR135W-A YMR135W-A hom Dubious 0.841719871377086 0.199972386317164 no 955 0.164041314590304 529 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YIL056W YIL056W VHR1 hom Verified 0.841702304181115 0.199977304091153 no 956 0.164378514975966 541 NA FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS NUCLEUS Transcriptional activator; required for the vitamin H-responsive element (VHRE) mediated induction of VHT1 (Vitamin H transporter) and BIO5 (biotin biosynthesis intermediate transporter) in response to low biotin concentrations; VHR1 has a paralog, VHR2, that arose from the whole genome duplication regulation of transcription from RNA polymerase II promoter in response to biotin starvation|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity nucleus|cytoplasm
YDR226W YDR226W ADK1 hom Verified 0.841314254494651 0.200085953553932 no 957 0.210078094040903 765 NA FT NUCLEOTIDE METABOLISM MITOCHONDRION Adenylate kinase, required for purine metabolism; localized to the cytoplasm and the mitochondria; lacks cleavable signal sequence; protein abundance increases in response to DNA replication stress ADP biosynthetic process|DNA replication initiation|nucleotide metabolic process adenylate kinase activity mitochondrion|mitochondrial intermembrane space|cytoplasm
YJR125C YJR125C ENT3 hom Verified 0.84123334821808 0.200108610853295 no 958 0.198160313645647 664 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS|CYTOSKELETON Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p late endosome to vacuole transport via multivesicular body sorting pathway|early endosome to Golgi transport|actin filament organization|endocytosis|actin cortical patch assembly|Golgi to endosome transport protein binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding clathrin vesicle coat|actin cortical patch
YIL131C YIL131C FKH1 hom Verified 0.840971709921894 0.200181891587154 no 959 0.201274510060309 668 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|RNA PROCESSING|CHROMATIN ORGANIZATION|MITOCHONDRION ORGANIZATION|GENE SILENCING NUCLEUS|CHROMOSOME Forkhead family transcription factor; has a minor role in the expression of G2/M phase genes; negatively regulates transcriptional elongation; positive role in chromatin silencing at HML and HMR; binds to the recombination enhancer near HML, and regulates donor preference during mating-type switching by positioning HML near the MAT locus through FHA-domain mediated interactions with proteins near the DSB; FKH1 has a paralog, FKH2, that arose from the whole genome duplication mRNA 3'-end processing|termination of RNA polymerase II transcription|donor selection|negative regulation of transcription involved in G1 phase of mitotic cell cycle|positive regulation of transcription involved in G2/M-phase of mitotic cell cycle|cellular response to methylmercury|positive regulation of chromatin silencing at silent mating-type cassette|negative regulation of transcription elongation from RNA polymerase II promoter|Unknown|negative regulation of transcription involved in G2/M-phase of mitotic cell cycle|chromatin remodeling RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|centromeric DNA binding nucleus
YLR278C_p YLR278C YLR278C hom Uncharacterized 0.840564029531486 0.200296108532578 no 960 0.213794694478718 721 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Zinc-cluster protein; GFP-fusion protein localizes to the nucleus; mutant shows moderate growth defect on caffeine; has a prion-domain like fragment that increases frequency of [URE3]; YLR278C is not an essential gene biological_process sequence-specific DNA binding nucleus
YNL044W YNL044W YIP3 hom Verified 0.837794437947384 0.201073081551312 no 961 0.194131743951467 666 NA FT VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS Protein localized to COPII vesicles, proposed to be involved in ER to Golgi transport; interacts with members of the Rab GTPase family and Yip1p; also interacts with Rtn1p ER to Golgi vesicle-mediated transport molecular_function Golgi apparatus|endoplasmic reticulum|ER to Golgi transport vesicle
YGR018C_p YGR018C YGR018C hom Uncharacterized 0.837780276991087 0.201077058863492 no 962 0.170308396843632 559 NA Protein of unknown function; mRNA identified as translated by ribosome profiling data; partially overlaps the uncharacterized ORF YGR017W biological_process molecular_function cellular_component
YOR219C YOR219C STE13 hom Verified 0.836782523648506 0.20135741128971 no 963 0.210131556320471 699 NA FT PROTEOLYSIS GOLGI APPARATUS Dipeptidyl aminopeptidase, Golgi integral membrane protein that cleaves on the carboxyl side of repeating -X-Ala- sequences, required for maturation of alpha factor, transcription is induced by a-factor peptide pheromone maturation aminopeptidase activity trans-Golgi network
YMR278W YMR278W PGM3 hom Verified 0.836287691491704 0.201496537929855 no 964 0.178519153626859 646 NA FT CARBOHYDRATE METABOLISM NUCLEUS Phosphoglucomutase, catalyzes interconversion of glucose-1-phosphate and glucose-6-phospate; transcription induced in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; non-essential biological_process phosphoglucomutase activity nucleus|cytoplasm
YDR071C YDR071C PAA1 hom Verified 0.835825444400789 0.20162655499974 no 965 0.212266355855337 731 NA FT CHROMATIN ORGANIZATION Polyamine acetyltransferase; acetylates polyamines (e.g. putrescine, spermidine, spermine) and also aralkylamines (e.g. tryptamine, phenylethylamine); may be involved in transcription and/or DNA replication chromatin organization diamine N-acetyltransferase activity|aralkylamine N-acetyltransferase activity cytoplasm
YKR035C_d YKR035C OPI8 hom Dubious 0.835608059084831 0.201687716728702 no 966 0.242801232252152 824 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene DID2/YKR035W-A Unknown Unknown Unknown
YCR077C YCR077C PAT1 hom Verified 0.835178679093878 0.201808556167289 no 967 0.218866633000575 776 NA FF|FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|TRANSLATION|CELL DIVISION|CHROMOSOME SEGREGATION NUCLEUS RIBOSOME Deadenylation-dependent mRNA-decapping factor; also required for faithful chromosome transmission, maintenance of rDNA locus stability, and protection of mRNA 3'-UTRs from trimming; associated with topoisomerase II; functionally linked to Pab1p; forms cytoplasmic foci upon DNA replication stress deadenylation-dependent decapping of nuclear-transcribed mRNA|chromosome segregation|regulation of translational initiation|formation of translation preinitiation complex|negative regulation of translational initiation|cytoplasmic mRNA processing body assembly molecular_function cytosolic small ribosomal subunit|cytoplasmic mRNA processing body
YFR025C YFR025C HIS2 hom Verified 0.835146436550288 0.201817631862893 no 968 0.176746364617589 557 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Histidinolphosphatase, catalyzes the eighth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control histidine biosynthetic process histidinol-phosphatase activity intracellular
YKL101W YKL101W HSL1 hom Verified 0.834770228636655 0.201923545679103 no 969 0.210776538103703 718 NA FT CELL CYCLE|CELL DIVISION|PROTEIN PHOSPHORYLATION SITE OF POLARIZED GROWTH|CYTOSKELETON Nim1p-related protein kinase that regulates the morphogenesis and septin checkpoints; associates with the assembled septin filament; required along with Hsl7p for bud neck recruitment, phosphorylation, and degradation of Swe1p G2/M transition of mitotic cell cycle|regulation of cell cycle|cell shape checkpoint|protein autophosphorylation|protein phosphorylation|septin checkpoint protein kinase activity cellular bud neck|septin ring
YNL141W YNL141W AAH1 hom Verified 0.834094244571291 0.202113939065432 no 970 0.202881955370504 719 NA FT NUCLEOTIDE METABOLISM NUCLEUS Adenine deaminase (adenine aminohydrolase), converts adenine to hypoxanthine; involved in purine salvage; transcriptionally regulated by nutrient levels and growth phase; Aah1p degraded upon entry into quiescence via SCF and the proteasome adenine catabolic process|hypoxanthine salvage|purine-containing compound salvage adenine deaminase activity nucleus|cytoplasm
YHR029C YHR029C YHI9 hom Verified 0.833881273089765 0.202173945508593 no 971 0.215179587517042 718 NA FT SIGNALING Protein of unknown function; null mutant is defective in unfolded protein response; possibly involved in a membrane regulation metabolic pathway; member of the PhzF superfamily, though most likely not involved in phenazine production endoplasmic reticulum unfolded protein response molecular_function cellular_component
YGL166W YGL166W CUP2 hom Verified 0.833736968400192 0.202214610583174 no 972 0.211587725097464 689 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Copper-binding transcription factor; activates transcription of the metallothionein genes CUP1-1 and CUP1-2 in response to elevated copper concentrations; CUP2 has a paralog, HAA1, that arose from the whole genome duplication regulation of transcription from RNA polymerase II promoter|response to copper ion RNA polymerase II core promoter proximal region sequence-specific DNA binding|copper ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity|copper ion binding nucleus
YOR165W YOR165W SEY1 hom Verified 0.833549086158898 0.202267563147939 no 973 0.207959116310849 729 NA FT MEMBRANE ORGANIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Dynamin-like GTPase that mediates homotypic ER fusion; has a role in ER morphology; interacts physically and genetically with Yop1p and Rtn1p; functional ortholog of the human atlastin ATL1, defects in which cause a form of the human disease hereditary spastic paraplegia; homolog of Arabidopsis RHD3 cellular membrane organization|endoplasmic reticulum organization|endoplasmic reticulum membrane fusion|endoplasmic reticulum inheritance GTPase activity integral to membrane|endoplasmic reticulum|cortical endoplasmic reticulum|cytoplasm
YGR132C YGR132C PHB1 hom Verified 0.833493055982315 0.202283356248825 no 974 0.180004191803079 584 NA FT MEMBRANE ORGANIZATION|PROTEOLYSIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation mitochondrion inheritance|protein folding|negative regulation of proteolysis|replicative cell aging|mitochondrion morphogenesis|inner mitochondrial membrane organization molecular_function mitochondrion|mitochondrial inner membrane
YMR263W YMR263W SAP30 hom Verified 0.833361462963195 0.20232045097988 no 975 0.223663375745005 799 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS|CHROMOSOME Subunit of a histone deacetylase complex, along with Rpd3p and Sin3p, that is involved in silencing at telomeres, rDNA, and silent mating-type loci; involved in telomere maintenance positive regulation of transcription from RNA polymerase II promoter in response to heat stress|negative regulation of chromatin silencing at silent mating-type cassette|negative regulation of transcription from RNA polymerase I promoter|negative regulation of chromatin silencing at telomere|negative regulation of chromatin silencing at rDNA|positive regulation of transcription from RNA polymerase II promoter histone deacetylase activity histone deacetylase complex|Rpd3L-Expanded complex|Rpd3L complex
YNL085W YNL085W MKT1 hom Verified 0.833328347212791 0.202329786613156 no 976 0.197212254730858 686 NA FT RESPONSE TO DNA DAMAGE|TRANSLATION Protein that forms a complex with Pbp1p; complex may mediate posttranscriptional regulation of HO; involved in propagation of M2 dsRNA satellite of L-A virus; allelic variation affects mitochondrial genome stability, drug resistance, and more; forms cytoplasmic foci upon DNA replication stress positive regulation of translation|interspecies interaction between organisms|response to DNA damage stimulus nuclease activity polysome|cytoplasm
YER095W YER095W RAD51 hom Verified 0.832849508821583 0.202464804334021 no 977 0.232716429037444 800 NA FF|FT CELL CYCLE|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME Strand exchange protein, forms a helical filament with DNA that searches for homology; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; homolog of Dmc1p and bacterial RecA protein strand invasion|telomere maintenance via recombination|heteroduplex formation|meiotic joint molecule formation|reciprocal meiotic recombination|double-strand break repair via single-strand annealing recombinase activity|single-stranded DNA binding|DNA-dependent ATPase activity condensed nuclear chromosome|nuclear chromosome
YGR266W YGR266W YGR266W hom Verified 0.832376105227647 0.20259834255142 no 978 0.194477375147528 658 NA FT MITOCHONDRION|PLASMA MEMBRANE Protein of unknown function; predicted to contain a single transmembrane domain; mutant has increased aneuploidy tolerance; localized to both the mitochondrial outer membrane and the plasma membrane; protein abundance increases in response to DNA replication stress biological_process molecular_function mitochondrial outer membrane|mitochondrion|plasma membrane
YOR239W YOR239W ABP140 hom Verified 0.832243829942803 0.202635664320121 no 979 0.195397795349046 634 NA FT RNA PROCESSING|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH|CYTOSKELETON AdoMet-dependent tRNA methyltransferase and actin binding protein; C-terminal domain is responsible for 3-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA-Thr and tRNA-Ser and contains an S-adenosylmethionine (AdoMet) binding motif; N-terminal actin binding sequence interacts with actin filaments and localizes to actin patches and cables; N- and C-terminal domains are encoded in separate ORFs that are translated into one protein via a +1 frameshift actin filament bundle assembly|tRNA methylation tRNA (cytosine-3-)-methyltransferase activity|actin filament binding|protein binding, bridging actin filament|actin filament bundle|mating projection tip|actin cortical patch
YLL016W YLL016W SDC25 hom pseudogene 0.831270019483438 0.202910553586313 no 980 0.197321353034916 672 NA FT SIGNALING Non-essential Ras guanine nucleotide exchange factor (GEF); localized to the membrane; expressed in poor nutrient conditions and on nonfermentable carbon sources; contains a stop codon in S288C, full-length gene includes YLL017W; SDC25 has a paralog, CDC25, that arose from the whole genome duplication Ras protein signal transduction Ras guanyl-nucleotide exchange factor activity cellular_component
YOR042W YOR042W CUE5 hom Verified 0.831199592557555 0.202930442480111 no 981 0.211345151037146 723 NA Protein containing a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern biological_process ubiquitin binding cytoplasm
YJL134W YJL134W LCB3 hom Verified 0.830834756268433 0.203033492595081 no 982 0.197685421344298 643 NA FT LIPID METABOLISM|SIGNALING ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Long-chain base-1-phosphate phosphatase; specific for dihydrosphingosine-1-phosphate, regulates ceramide and long-chain base phosphates levels, involved in incorporation of exogenous long chain bases in sphingolipids; LCB3 has a paralog, YSR3, that arose from the whole genome duplication calcium-mediated signaling|sphingolipid biosynthetic process sphingosine-1-phosphate phosphatase activity integral to membrane|endoplasmic reticulum
YKL150W YKL150W MCR1 hom Verified 0.83011688745179 0.20323634999333 no 983 0.236807257065489 791 NA FT LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS MITOCHONDRION Mitochondrial NADH-cytochrome b5 reductase, involved in ergosterol biosynthesis ergosterol biosynthetic process|cellular response to oxidative stress cytochrome-b5 reductase activity mitochondrial outer membrane|mitochondrion|integral to mitochondrial outer membrane|mitochondrial intermembrane space
YDR541C_p YDR541C YDR541C hom Uncharacterized 0.829143989058404 0.203511467354103 no 984 0.208860605465122 711 NA FT OXIDATION-REDUCTION PROCESS Putative dihydrokaempferol 4-reductase biological_process carbonyl reductase (NADPH) activity cellular_component
YJL162C YJL162C JJJ2 hom Verified 0.828613345943475 0.203661616819767 no 985 0.190278317473263 651 NA FT NUCLEUS Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein biological_process molecular_function nucleus|cytoplasm
YIL008W YIL008W URM1 hom Verified 0.82858829514528 0.203668706764164 no 986 0.211692797951145 726 NA FT RNA PROCESSING|CELL DIVISION|RESPONSE TO OXIDATIVE STRESS NUCLEUS Ubiquitin-like protein involved in thiolation of cytoplasmic tRNAs; receives sulfur from the E1-like enzyme Uba4p and transfers it to tRNA; also functions as a protein tag with roles in nutrient sensing and oxidative stress response cellular response to oxidative stress|tRNA wobble position uridine thiolation|cell budding|protein urmylation|invasive growth in response to glucose limitation|tRNA wobble uridine modification protein tag cytosol|nucleus|cytoplasm
YNL286W YNL286W CUS2 hom Verified 0.82826621591106 0.203759875605881 no 987 0.207552128952812 687 NA FT RNA PROCESSING NUCLEUS Protein that binds to U2 snRNA and Prp11p, may be involved in U2 snRNA folding; contains two RNA recognition motifs (RRMs) mRNA splicing, via spliceosome RNA binding U2 snRNP
YNL311C YNL311C SKP2 hom Verified 0.82798547488773 0.203839362954893 no 988 0.192463880833891 626 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|PROTEOLYSIS UBIQUITIN LIGASE COMPLEX F-box protein of unknown function predicted to be part of an SCF ubiquitin protease complex; involved in regulating protein levels of sulfur metabolism enzymes; may interact with ribosomes, based on co-purification experiments SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|cellular protein catabolic process|regulation of sulfur amino acid metabolic process ubiquitin-protein ligase activity|protein binding, bridging ribosome|SCF ubiquitin ligase complex
YMR291W YMR291W TDA1 hom Verified 0.82785858305363 0.203875296420364 no 989 0.193014186778602 651 NA FT PROTEIN PHOSPHORYLATION NUCLEUS Protein kinase of unknown cellular role; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; null mutant is sensitive to expression of the top1-T722A allele; not an essential gene; relocalizes from nucleus to cytoplasm upon DNA replication stress protein phosphorylation protein kinase activity nucleus|cytoplasm
YER015W YER015W FAA2 hom Verified 0.826169629293217 0.204353936924744 no 990 0.207211772353962 721 NA FT KETONE METABOLISM|LIPID METABOLISM MITOCHONDRION Medium chain fatty acyl-CoA synthetase, activates imported fatty acids; accepts a wide range of fatty acid chain lengths with a preference for medium chains, C9:0-C13:0; localized to the peroxisome long-chain fatty acid metabolic process long-chain fatty acid-CoA ligase activity|very long-chain fatty acid-CoA ligase activity|medium-chain fatty acid-CoA ligase activity mitochondrion|peroxisome
YJR058C YJR058C APS2 hom Verified 0.825578568165972 0.204521598395419 no 991 0.158825793010316 522 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|PLASMA MEMBRANE Small subunit of the clathrin-associated adaptor complex AP-2, which is involved in protein sorting at the plasma membrane; related to the sigma subunit of the mammalian plasma membrane clathrin-associated protein (AP-2) complex vesicle-mediated transport molecular_function AP-2 adaptor complex
YMR031W-A_d YMR031W-A YMR031W-A hom Dubious 0.825463782809408 0.204554168107548 no 992 0.203016906270599 666 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays shortened telomeres; partially overlaps the uncharacterized ORF YMR031C Unknown Unknown Unknown
YMR311C YMR311C GLC8 hom Verified 0.825393213848132 0.204574193193189 no 993 0.217079279702383 756 NA FT SIGNALING|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|CHROMOSOME SEGREGATION NUCLEUS Regulatory subunit of protein phosphatase 1 (Glc7p); involved in glycogen metabolism and chromosome segregation; proposed to regulate Glc7p activity via conformational alteration; ortholog of the mammalian protein phosphatase inhibitor 2; protein abundance increases in response to DNA replication stress chromosome segregation|glycogen biosynthetic process enzyme activator activity nucleus|cytoplasm
YJR005C-A_p YJR005C-A YJR005C-A hom Uncharacterized 0.82451771465834 0.204822727259496 no 994 0.192371701286194 636 NA Putative protein of unknown function; originally identified as a syntenic homolog of an Ashbya gossypii gene; YJR005C-A has a paralog, YGR169C-A, that arose from the whole genome duplication biological_process molecular_function cellular_component
YHR096C YHR096C HXT5 hom Verified 0.824224289202592 0.204906064150007 no 995 0.221870966594421 725 NA FT PLASMA MEMBRANE Hexose transporter with moderate affinity for glucose; induced in the presence of non-fermentable carbon sources, induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs; HXT5 has a paralog, HXT3, that arose from the whole genome duplication glucose transport|hexose transport mannose transmembrane transporter activity|fructose transmembrane transporter activity|glucose transmembrane transporter activity integral to membrane|plasma membrane
YPL005W YPL005W AEP3 hom Verified 0.823823489749784 0.205019929312585 no 996 0.203482537050708 692 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Protein that may facilitate use of unformylated tRNA-Met in mitochondrial translation initiation; localized to the matrix face of the mitochondrial inner membrane; stabilizes the bicistronic AAP1-ATP6 mRNA mRNA metabolic process|mitochondrial translational initiation molecular_function mitochondrion|mitochondrial inner membrane|cytoplasm|extrinsic to membrane
YNL225C YNL225C CNM67 hom Verified 0.823407933618857 0.205138026480424 no 997 0.237221998216871 832 NA FT CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION NUCLEUS|CYTOSKELETON Component of the spindle pole body outer plaque; required for spindle orientation and mitotic nuclear migration; CNM67 has a paralog, ADY3, that arose from the whole genome duplication microtubule nucleation|mitotic spindle organization structural constituent of cytoskeleton outer plaque of spindle pole body|spindle pole body
YML062C YML062C MFT1 hom Verified 0.823148837731539 0.205211679565489 no 998 0.218511892980723 760 NA FT TRANSCRIPTION FROM RNA POL II|RNA LOCALIZATION NUCLEUS Subunit of the THO complex, which is a nuclear complex comprised of Hpr1p, Mft1p, Rlr1p, and Thp2p, that is involved in transcription elongation and mitotic recombination; involved in telomere maintenance mRNA export from nucleus|DNA recombination|transcription elongation from RNA polymerase II promoter protein complex scaffold|nucleic acid binding THO complex part of transcription export complex|nucleoplasmic THO complex
YGR228W_d YGR228W YGR228W hom Dubious 0.822952822665511 0.205267411128956 no 999 0.232746374071601 810 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SMI1/YGR229C Unknown Unknown Unknown
YKL003C YKL003C MRP17 hom Verified 0.822794713801699 0.205312371643701 no 1000 0.214456073823195 714 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the small subunit; MRP17 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial small ribosomal subunit
YPR030W YPR030W CSR2 hom Verified 0.822794001991663 0.205312574070283 no 1001 0.218171122404172 745 NA FT VESICLE-MEDIATED TRANSPORT|TRANSCRIPTION FROM RNA POL II|MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS NUCLEUS Nuclear ubiquitin protein ligase binding protein; may regulate utilization of nonfermentable carbon sources and endocytosis of plasma membrane proteins; overproduction suppresses chs5 spa2 lethality at high temp; ubiquitinated by Rsp5p, deubiquitinated by Ubp2p; CSR2 has a paralog, ECM21, that arose from the whole genome duplication fungal-type cell wall organization|regulation of transcription from RNA polymerase II promoter|ubiquitin-dependent endocytosis ubiquitin protein ligase binding nucleus
YLL006W-A_p YLL006W-A YLL006W-A hom Uncharacterized 0.82272827891217 0.205331265099158 no 1002 0.176167449863642 587 NA Putative protein of unknown function; identified by fungal homology and RT-PCR biological_process molecular_function cellular_component
YOR114W_p YOR114W YOR114W hom Uncharacterized 0.822367448372442 0.205433899934426 no 1003 0.210875142339613 721 NA Putative protein of unknown function; null mutant is viable biological_process molecular_function cellular_component
YGL023C YGL023C PIB2 hom Verified 0.822065915736669 0.205519691404437 no 1004 0.21988584219609 740 NA FT VESICLE-MEDIATED TRANSPORT MITOCHONDRION Protein of unknown function; contains FYVE domain; similar to Fab1 and Vps27 biological_process molecular_function mitochondrion
YNR004W_p YNR004W SWM2 hom Uncharacterized 0.822013635520211 0.205534568231915 no 1005 0.196454149544614 688 NA FT NUCLEUS Putative protein of unknown function; haploid disruptant exhibits cold-sensitive growth and elongated buds biological_process molecular_function nucleolus
YBR074W_p YBR074W YBR074W hom Uncharacterized 0.820563309335991 0.205947527030028 no 1006 0.221938939245717 777 NA FT PROTEOLYSIS Putative metalloprotease biological_process molecular_function cellular_component
YLR295C YLR295C ATP14 hom Verified 0.82011974673514 0.206073923088273 no 1007 0.234674214830216 793 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS MITOCHONDRION Subunit h of the F0 sector of mitochondrial F1F0 ATP synthase; F1F0 ATP synthase is a large, evolutionarily conserved enzyme complex required for ATP synthesis; protein abundance increases in response to DNA replication stress cristae formation|mitochondrial proton-transporting ATP synthase complex assembly|ATP synthesis coupled proton transport hydrogen ion transporting ATP synthase activity, rotational mechanism|ATPase activity|proton-transporting ATPase activity, rotational mechanism mitochondrion|integral to membrane|mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
YPL261C_d YPL261C YPL261C hom Dubious 0.820064538346575 0.206089658297292 no 1008 0.202715229542748 707 NA Dubious open reading frame unlikely to encode a protein; partially overlaps the uncharacterized ORF YPL260W Unknown Unknown Unknown
YNL027W YNL027W CRZ1 hom Verified 0.820035461195831 0.206097946002644 no 1009 0.193284128385215 608 NA FT TRANSCRIPTION FROM RNA POL II|SIGNALING|ION HOMEOSTASIS|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|ION HOMEOSTASIS NUCLEUS Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress regulation of potassium ion concentration by positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter in response to calcium ion|positive regulation of sodium ion transport by positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter in response to increased salt|cell wall chitin biosynthetic process|positive regulation of transcription from RNA polymerase II promoter in response to alkalinity|positive regulation of transcription from RNA polymerase II promoter by pheromones|ion homeostasis|Unknown|positive regulation of transcription from RNA polymerase II promoter core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus|cytoplasm
YPL103C YPL103C FMP30 hom Verified 0.819431546145153 0.206270121363408 no 1010 0.210017241517887 708 NA FT LIPID METABOLISM MITOCHONDRION Mitochondrial inner membrane protein with a role in maintaining mitochondrial morphology and normal cardiolipin levels; proposed to be involved in N-acylethanolamine metabolism; related to mammalian N-acylPE-specific phospholipase D N-acylphosphatidylethanolamine metabolic process|N-acylethanolamine metabolic process NAPE-specific phospholipase D activity mitochondrion|integral to mitochondrial inner membrane
YJR135W-A YJR135W-A TIM8 hom Verified 0.819358323109564 0.206291002944909 no 1011 0.190299726499169 621 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial intermembrane space protein, forms a complex with Tim13p that delivers a subset of hydrophobic proteins to the TIM22 complex for inner membrane insertion; homolog of human TIMM8A, implicated in Mohr-Tranebjaerg syndrome protein import into mitochondrial inner membrane protein transporter activity mitochondrion|integral to membrane|mitochondrial intermembrane space protein transporter complex
YBR159W YBR159W IFA38 hom Verified 0.818253699836352 0.206606168929241 no 1012 0.207895991186334 712 NA FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Microsomal beta-keto-reductase; contains oleate response element (ORE) sequence in the promoter region; mutants exhibit reduced VLCFA synthesis, accumulate high levels of dihydrosphingosine, phytosphingosine and medium-chain ceramides fatty acid elongation ketoreductase activity integral to membrane|endoplasmic reticulum
YGR203W YGR203W YCH1 hom Verified 0.817201888945053 0.206906531614305 no 1013 0.206339941767 691 NA FT NUCLEUS Phosphatase with sequence similarity to Cdc25p, Arr2p and Mih1p; member of the single-domain rhodanese homology superfamily; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus dephosphorylation phosphatase activity|protein tyrosine phosphatase activity|thiosulfate sulfurtransferase activity nucleus|cytoplasm
YDR192C YDR192C NUP42 hom Verified 0.816026860144823 0.207242386730909 no 1014 0.206757984391439 689 NA FT PROTEIN LOCALIZATION|RNA LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS NUCLEAR PORE FG-nucleoporin component of central core of the nuclear pore complex (NPC); also part of the NPC cytoplasmic filaments; contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier and is involved in gene tethering at the nuclear periphery; interacts with Gle1p poly(A)+ mRNA export from nucleus|NLS-bearing substrate import into nucleus|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|mRNA export from nucleus in response to heat stress|transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery nucleocytoplasmic transporter activity|structural constituent of nuclear pore nuclear pore central transport channel|integral to membrane|nuclear pore cytoplasmic filaments|nuclear pore
YNL300W_p YNL300W TOS6 hom Uncharacterized 0.815748304973537 0.207322052606496 no 1015 0.225758496692748 793 NA Glycosylphosphatidylinositol-dependent cell wall protein, expression is periodic and decreases in respone to ergosterol perturbation or upon entry into stationary phase; depletion increases resistance to lactic acid biological_process molecular_function fungal-type cell wall
YAL056W YAL056W GPB2 hom Verified 0.815231751803186 0.207469833052103 no 1016 0.201410581933847 665 NA FT TRANSCRIPTION FROM RNA POL II|SIGNALING MITOCHONDRION|PLASMA MEMBRANE Multistep regulator of cAMP-PKA signaling; inhibits PKA downstream of Gpa2p and Cyr1p, thereby increasing cAMP dependency; inhibits Ras activity through direct interactions with Ira1p/2p; regulated by G-alpha protein Gpa2p; GPB2 has a paralog, GPB1, that arose from the whole genome duplication signal transduction|glucose mediated signaling pathway|pseudohyphal growth|ascospore formation|negative regulation of Ras protein signal transduction|invasive growth in response to glucose limitation|positive regulation of transcription from RNA polymerase II promoter cAMP-dependent protein kinase inhibitor activity|signal transducer activity|GTPase activating protein binding mitochondrion|plasma membrane|cytoplasm
YGR284C YGR284C ERV29 hom Verified 0.815212982286362 0.207475203986096 no 1017 0.213889722567173 727 NA FT VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Protein localized to COPII-coated vesicles; involved in vesicle formation and incorporation of specific secretory cargo; protein abundance increases in response to DNA replication stress ER to Golgi vesicle-mediated transport molecular_function integral to membrane|ER to Golgi transport vesicle
YHR103W YHR103W SBE22 hom Verified 0.814291659523674 0.207738943309937 no 1018 0.211367107702651 710 NA FT PROTEIN LOCALIZATION|CELL WALL ORG/BIOGENESIS GOLGI APPARATUS Protein involved in the transport of cell wall components from the Golgi to the cell surface; similar in structure and functionally redundant with Sbe2p; involved in bud growth fungal-type cell wall organization molecular_function cytoplasm
YCL075W YCL075W YCL075W hom pseudogene 0.812929258185984 0.208129309232606 no 1019 0.18539037122939 648 NA FT NUCLEUS Pseudogene: encodes fragment of Ty Pol protein transposition, RNA-mediated ribonuclease activity|peptidase activity|RNA binding|RNA-directed DNA polymerase activity|DNA-directed DNA polymerase activity retrotransposon nucleocapsid
YML037C_p YML037C YML037C hom Uncharacterized 0.812703219114637 0.208194117567083 no 1020 0.237121938220868 816 NA Putative protein of unknown function with some characteristics of a transcriptional activator; may be a target of Dbf2p-Mob1p kinase; GFP-fusion protein co-localizes with clathrin-coated vesicles; YML037C is not an essential gene biological_process molecular_function clathrin-coated vesicle
YPR109W_p YPR109W YPR109W hom Uncharacterized 0.812574047432277 0.208231158110582 no 1021 0.228512342971641 756 NA FT CELL CYCLE Predicted membrane protein; dipoid deletion strain has high budding index biological_process molecular_function cellular_component
YPR089W_p YPR089W YPR089W hom Uncharacterized 0.812226708277384 0.208330778411903 no 1022 0.214082118121386 759 NA FT GOLGI APPARATUS Protein of unknown function; exhibits genetic interaction with ERG11 and protein-protein interaction with Hsp82p biological_process molecular_function cellular_component
YHL034C YHL034C SBP1 hom Verified 0.811813460372133 0.208449338608935 no 1023 0.190820253963347 702 NA FT TRANSLATION NUCLEUS Protein that binds eIF4G and has a role in repression of translation; has an RGG motif; found in cytoplasmic P bodies; found associated with small nucleolar RNAs snR10 and snR11 negative regulation of translation|negative regulation of translation in response to stress RNA binding|eukaryotic initiation factor 4G binding nucleolus|cytoplasmic mRNA processing body|cytoplasm
YBL031W YBL031W SHE1 hom Verified 0.811520908942589 0.20853329522038 no 1024 0.207266831703691 732 NA FT CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION NUCLEUS|SITE OF POLARIZED GROWTH|CYTOSKELETON Mitotic spindle protein; interacts with components of the Dam1 (DASH) complex, its effector Sli15p, and microtubule-associated protein Bim1p; also localizes to nuclear microtubules and to the bud neck in a ring-shaped structure; inhibits dynein function mitotic spindle elongation molecular_function microtubule cytoskeleton|nuclear microtubule|cellular bud neck|astral microtubule|spindle
YLR168C YLR168C UPS2 hom Verified 0.810622564764583 0.208791227234935 no 1025 0.209301567593284 737 NA FT LIPID METABOLISM|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial protein involved in phospholipid metabolism; localizes to the intermembrane space; has a role in regulation of phospholipid metabolism by inhibiting conversion of phosphatidylethanolamine to phosphatidylcholine; null mutant has defects in mitochondrial morphology; similar to Ups1p, Ups3p and to human PRELI cristae formation|Unknown|phosphatidylethanolamine metabolic process|cardiolipin metabolic process molecular_function extrinsic to mitochondrial inner membrane|mitochondrion|mitochondrial intermembrane space
YJL022W_d YJL022W YJL022W hom Dubious 0.810606608769619 0.2087958102087 no 1026 0.217876799829615 697 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PET130 Unknown Unknown Unknown
YDR214W YDR214W AHA1 hom Verified 0.810236049848241 0.208902260972178 no 1027 0.219935001860272 737 NA FT NUCLEOTIDE METABOLISM Co-chaperone that binds to Hsp82p and activates its ATPase activity; similar to Hch1p; expression is regulated by stresses such as heat shock; protein abundance increases in response to DNA replication stress protein folding|response to stress ATPase activator activity|chaperone binding cytoplasm
YER177W YER177W BMH1 hom Verified 0.81009576113672 0.20894257016665 no 1028 0.211848875471913 751 NA FT CELL CYCLE|SIGNALING|RESPONSE TO DNA DAMAGE|CELL WALL ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY NUCLEUS 14-3-3 protein, major isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress glycogen metabolic process|pseudohyphal growth|signal transduction involved in filamentous growth|ascospore formation|fungal-type cell wall chitin biosynthetic process|Ras protein signal transduction|DNA damage checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle DNA replication origin binding|phosphoserine binding plasma membrane|nucleus
YBL107C YBL107C MIC23 hom Verified 0.809579538729381 0.209090935937272 no 1029 0.216713814728241 715 NA Mitochondrial intermembrane space protein of unknown function; imported via the MIA import machinery; contains an unusual twin cysteine motif (CX13C CX14C) biological_process molecular_function cytoplasm
YLR286C YLR286C CTS1 hom Verified 0.809502362332773 0.209113122278916 no 1030 0.196596305273623 696 NA FT CELL WALL ORG/BIOGENESIS|CELL DIVISION|CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|SITE OF POLARIZED GROWTH Endochitinase, required for cell separation after mitosis; transcriptional activation during the G1 phase of the cell cycle is mediated by transcription factor Ace2p cytokinesis, completion of separation|chitin catabolic process endochitinase activity nuclear envelope|extracellular region|fungal-type cell wall|endoplasmic reticulum|cellular bud neck
YIR036C_p YIR036C IRC24 hom Uncharacterized 0.808917437849242 0.209281318937496 no 1031 0.211424651019159 723 NA FT OXIDATION-REDUCTION PROCESS Putative benzil reductase;(GFP)-fusion protein localizes to the cytoplasm and is induced by the DNA-damaging agent MMS; sequence similarity with short-chain dehydrogenase/reductases; null mutant has increased spontaneous Rad52p foci biological_process molecular_function integral to membrane|cytoplasm
YOR027W YOR027W STI1 hom Verified 0.80863253713035 0.209363271759498 no 1032 0.217299445131466 743 NA Hsp90 cochaperone, interacts with the Ssa group of the cytosolic Hsp70 chaperones and activates Ssa1p ATPase activity; interacts with Hsp90 chaperones and inhibits their ATPase activity; homolog of mammalian Hop protein folding Hsp70 protein binding|Hsp90 protein binding|mRNA binding|ATPase inhibitor activity cytoplasm
YGR125W_p YGR125W YGR125W hom Uncharacterized 0.807807881159062 0.209600593742839 no 1033 0.208507954229966 747 NA Putative protein of unknown function; deletion mutant has decreased rapamycin resistance but normal wormannin resistance; green fluorescent protein (GFP)-fusion protein localizes to the vacuole biological_process molecular_function integral to membrane|fungal-type vacuole
YBL099W YBL099W ATP1 hom Verified 0.807564139326397 0.209670768784973 no 1034 0.222119191529401 808 NA FT ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS MITOCHONDRION Alpha subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated ATP synthesis coupled proton transport hydrogen ion transporting ATP synthase activity, rotational mechanism|ATPase activity|proton-transporting ATPase activity, rotational mechanism mitochondrial nucleoid|proton-transporting ATP synthase complex, catalytic core F(1)|mitochondrion|integral to membrane|mitochondrial proton-transporting ATP synthase, catalytic core
YMR274C YMR274C RCE1 hom Verified 0.807559965433542 0.20967197059932 no 1035 0.217205387203482 751 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Type II CAAX prenyl protease involved in the proteolysis and maturation of Ras and the a-factor mating pheromone CAAX-box protein processing|peptide pheromone maturation|protein processing metalloendopeptidase activity integral to endoplasmic reticulum membrane|integral to membrane
YOR121C_d YOR121C YOR121C hom Dubious 0.807558586202466 0.209672367730601 no 1036 0.204413398995713 701 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene GCY1/YOR120W Unknown Unknown Unknown
YHR200W YHR200W RPN10 hom Verified 0.807474461416693 0.209696591182242 no 1037 0.212116568749856 738 NA FT PROTEOLYSIS Non-ATPase base subunit of the 19S regulatory particle (RP) of the 26S proteasome; N-terminus plays a role in maintaining the structural integrity of the RP; binds selectively to polyubiquitin chains; homolog of the mammalian S5a protein ubiquitin-dependent protein catabolic process structural molecule activity|polyubiquitin binding proteasome complex|proteasome regulatory particle, base subcomplex
YFR017C YFR017C IGD1 hom Verified 0.80726753773102 0.20975618116931 no 1038 0.213432780102926 701 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY Cytoplasmic protein that inhibits Gdb1p glycogen debranching activity; required for normal intracellular accumulation of glycogen; phosphorylated in vivo; expression increases during wine fermentation; protein abundance increases in response to DNA replication stress; IGD1 has a paralog, YOL024W, that arose from the whole genome duplication negative regulation of glycogen catabolic process enzyme inhibitor activity cytoplasm
YDL063C YDL063C SYO1 hom Verified 0.806954823606834 0.209846255629915 no 1039 0.23014941985811 787 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS NUCLEUS Transport adaptor or symportin; facilitates synchronized nuclear coimport of the two 5S-rRNA binding proteins Rpl5p and Rpl11p; required for biogenesis of the large ribosomal subunit; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus ribosomal large subunit biogenesis molecular_function nucleus|cytoplasm
YPR059C_d YPR059C YPR059C hom Dubious 0.806716777376965 0.209914837921376 no 1040 0.225129142622362 813 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YMC1/YPR058W Unknown Unknown Unknown
YBR289W YBR289W SNF5 hom Verified 0.806706770140171 0.209917721344101 no 1041 0.227607206040644 710 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS NUCLEUS|CHROMOSOME RSC COMPLEX Subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; functions interdependently in transcriptional activation with Snf2p and Snf6p; relocates to the cytosol under hypoxic conditions sucrose catabolic process|double-strand break repair via homologous recombination|chromatin remodeling|carbon catabolite activation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II activating transcription factor binding SWI/SNF complex|nucleus
YGL003C YGL003C CDH1 hom Verified 0.806192287875774 0.210065992409964 no 1042 0.217737016727479 761 NA FT CELL CYCLE|CELL DIVISION|PROTEOLYSIS|CYTOSKELETON ORGANIZATION NUCLEUS UBIQUITIN LIGASE COMPLEX Cell-cycle regulated activator of the anaphase-promoting complex/cyclosome (APC/C), which directs ubiquitination of cyclins resulting in mitotic exit; targets the APC/C to specific substrates including Cdc20p, Ase1p, Cin8p and Fin1p activation of mitotic anaphase-promoting complex activity|negative regulation of spindle pole body separation|positive regulation of mitotic metaphase/anaphase transition|Unknown|regulation of cell size anaphase-promoting complex binding|cyclin binding|ubiquitin-protein ligase activator activity nucleus|anaphase-promoting complex|cytoplasm
YML078W YML078W CPR3 hom Verified 0.805937531314966 0.210139434673859 no 1043 0.219061583089134 759 NA FT MITOCHONDRION Mitochondrial peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; involved in protein refolding after import into mitochondria protein folding|apoptotic process peptidyl-prolyl cis-trans isomerase activity mitochondrion
YIL114C YIL114C POR2 hom Verified 0.804691464261124 0.210498873226146 no 1044 0.207732354720541 674 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION Putative mitochondrial porin (voltage-dependent anion channel); not required for mitochondrial membrane permeability or mitochondrial osmotic stability; POR2 has a paralog, POR1, that arose from the whole genome duplication DNA transport|ion transport|cell redox homeostasis voltage-gated anion channel activity mitochondrial outer membrane|mitochondrion|integral to membrane
YIL076W YIL076W SEC28 hom Verified 0.803953461067539 0.210711926511148 no 1045 0.201557087719469 697 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Epsilon-COP subunit of the coatomer; regulates retrograde Golgi-to-ER protein traffic; stabilizes Cop1p, the alpha-COP and the coatomer complex; non-essential for cell growth; protein abundance increases in response to DNA replication stress late endosome to vacuole transport via multivesicular body sorting pathway|ER to Golgi vesicle-mediated transport|vesicle coating molecular_function endosome|COPI vesicle coat
YNR025C_d YNR025C YNR025C hom Dubious 0.802949020373725 0.211002100482927 no 1046 0.206332991893587 725 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion reduces expression of PIS1 gene encoding phosphatidylinositol synthase Unknown Unknown Unknown
YKR011C YKR011C YKR011C hom Verified 0.802325195343017 0.211182435842665 no 1047 0.200164580472297 682 NA FT NUCLEUS Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; protein abundance increases in response to DNA replication stress biological_process molecular_function nucleus
YIL161W_p YIL161W YIL161W hom Uncharacterized 0.801170920264292 0.211516351774871 no 1048 0.189142175079837 656 NA Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; mRNA is enriched in Scp160p-associated mRNPs; YIL161W is a non-essential gene biological_process molecular_function cytoplasm
YBL071C_d YBL071C YBL071C hom Dubious 0.800655669804488 0.211665506400226 no 1049 0.208284103323995 691 NA Dubious open reading frame, predicted protein contains a peroxisomal targeting signal Unknown Unknown Unknown
YNL179C_d YNL179C YNL179C hom Dubious 0.799406863943202 0.212027265851658 no 1050 0.211684767009856 762 NA Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; deletion in cyr1 mutant results in loss of stress resistance Unknown Unknown Unknown
YBL103C YBL103C RTG3 hom Verified 0.799010169891095 0.212142257519438 no 1051 0.203992504211299 678 NA FT PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|SIGNALING NUCLEUS Basic helix-loop-helix-leucine zipper (bHLH/Zip) transcription factor that forms a complex with another bHLH/Zip protein, Rtg1p, to activate the retrograde (RTG) and TOR pathways mitochondrion degradation|cellular response to oleic acid|mitochondria-nucleus signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription factor import into nucleus RNA polymerase II transcription factor binding|sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity nucleus|cytoplasm
YCR025C_d YCR025C YCR025C hom Dubious 0.79745090334206 0.212594603017484 no 1052 0.227934839047984 825 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR025C is not an essential gene Unknown Unknown Unknown
YOR107W YOR107W RGS2 hom Verified 0.796517867282378 0.212865547312857 no 1053 0.227551739373398 810 NA FT SIGNALING NUCLEUS|PLASMA MEMBRANE Negative regulator of glucose-induced cAMP signaling; directly activates the GTPase activity of the heterotrimeric G protein alpha subunit Gpa2p adenylate cyclase-modulating G-protein coupled receptor signaling pathway GTPase activator activity nucleus|cytoplasm
YLR376C YLR376C PSY3 hom Verified 0.796206828489368 0.212955914625078 no 1054 0.20765487067162 729 NA FT RESPONSE TO DNA DAMAGE NUCLEUS Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function; structural analysis reveals a similar DNA-binding region in both Psy3p and Csm2p and that both regions work together to form a single DNA binding site; deletion of PSY3 results in a mutator phenotype; deletion increases sensitivity to anticancer drugs oxaliplatin and cisplatin but not mitomycin C recombinational repair|error-free translesion synthesis molecular_function nucleus|Shu complex|cytoplasm
YGR161C_p YGR161C RTS3 hom Uncharacterized 0.796121743064938 0.212980638723851 no 1055 0.210751595686617 711 NA FT NUCLEUS Putative component of the protein phosphatase type 2A complex biological_process molecular_function nucleus|cytoplasm
YHR031C YHR031C RRM3 hom Verified 0.795928760098824 0.213036721867192 no 1056 0.233695928297979 796 NA FT RESPONSE TO DNA DAMAGE|MITOCHONDRION ORGANIZATION NUCLEUS|CHROMOSOME DNA helicase involved in rDNA replication and Ty1 transposition; relieves replication fork pauses at telomeric regions; structurally and functionally related to Pif1p mitochondrial genome maintenance|replication fork progression beyond termination site|DNA replication ATP-dependent DNA helicase activity|DNA helicase activity nuclear telomeric heterochromatin|replication fork
YDR051C YDR051C DET1 hom Verified 0.795580925889031 0.213137828379401 no 1057 0.198649122006001 639 NA FT NUCLEUS Acid phosphatase involved in the non-vesicular transport of sterols in both directions between the endoplasmic reticulum and plasma membrane; deletion confers sensitivity to nickel intracellular sterol transport|dephosphorylation acid phosphatase activity nucleus|cytoplasm
YBL008W YBL008W HIR1 hom Verified 0.795094937193684 0.213279139729616 no 1058 0.222885578254251 729 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION NUCLEUS|CHROMOSOME Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; contributes to nucleosome formation, heterochromatic gene silencing, and formation of functional kinetochores DNA replication-independent nucleosome assembly|regulation of transcription from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter nucleosome binding|transcription corepressor activity|DNA binding chromosome, centromeric region|HIR complex|nucleus
YJL103C YJL103C GSM1 hom Verified 0.791964084275325 0.214190809214659 no 1059 0.220114264662908 737 NA FT TRANSCRIPTION FROM RNA POL II|GEN. OF PRECURSOR METABOLITES AND ENERGY NUCLEUS Putative zinc cluster protein of unknown function; proposed to be involved in the regulation of energy metabolism, based on patterns of expression and sequence analysis oxidative phosphorylation sequence-specific DNA binding|DNA binding cellular_component
YPL168W_p YPL168W YPL168W hom Uncharacterized 0.791633897683506 0.214287087862469 no 1060 0.22094583352377 730 NA FT MITOCHONDRION Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; expression may be cell cycle-regulated biological_process molecular_function mitochondrion
YBR086C YBR086C IST2 hom Verified 0.791048018526383 0.214457985498449 no 1061 0.228523794676928 752 NA FT PLASMA MEMBRANE Cortical ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; localizes to the mother cell in small-budded cells and to the bud in medium- and large-budded cells; mRNA is transported to the bud tip by an actomyosin-driven process response to osmotic stress lipid binding integral to membrane|cellular bud membrane|plasma membrane
YGR205W YGR205W TDA10 hom Verified 0.789882802316131 0.214798107914499 no 1062 0.186184351722947 649 NA FT NUCLEUS ATP-binding protein of unknown function; crystal structure resembles that of E.coli pantothenate kinase and other small kinases; null mutant is sensitive to expression of the top1-T722A allele biological_process ATP binding nucleus|cytoplasm
YDR017C YDR017C KCS1 hom Verified 0.789054933272205 0.215039950221984 no 1063 0.197156276481934 687 NA Inositol hexakisphosphate (IP6) and inositol heptakisphosphate (IP7) kinase; generation of high energy inositol pyrophosphates by Kcs1p is required for many processes such as vacuolar biogenesis, stress response and telomere maintenance inositol phosphate biosynthetic process inositol heptakisphosphate kinase activity|inositol hexakisphosphate kinase activity|inositol-1,3,4,5,6-pentakisphosphate kinase activity|inositol heptakisphosphate 5-kinase activity cytoplasm
YJL065C YJL065C DLS1 hom Verified 0.787934645039918 0.215367467467642 no 1064 0.244598960913767 828 NA FT GENE SILENCING NUCLEUS Subunit of ISW2/yCHRAC chromatin accessibility complex; ISW2/yCHRAC also includes Itc1p, Isw2p, and Dpb4p; involved in inheritance of telomeric silencing; DLS1 has a paralog, DPB3, that arose from the whole genome duplication chromatin silencing at telomere molecular_function chromatin accessibility complex|nucleus
YFR012W YFR012W DCV1 hom Verified 0.787567512719582 0.215474861854034 no 1065 0.196445949558018 681 NA Protein of unknown function; deletion mutant shows strong genetic interaction with cdc28-as1 mutant in the presence of 1-NM-PP1; DCV1 has a paralog, YOL019W, that arose from the whole genome duplication biological_process molecular_function integral to membrane
YNL005C YNL005C MRP7 hom Verified 0.786738034690247 0.215717617006891 no 1066 0.27244683696962 929 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit mitochondrial translation structural constituent of ribosome|peptidyltransferase activity mitochondrion|mitochondrial large ribosomal subunit
YNL277W-A_p YNL277W-A YNL277W-A hom Uncharacterized 0.782599078422701 0.216931291425155 no 1067 0.183603151554491 612 NA Putative protein of unknown function biological_process molecular_function cellular_component
YGR209C YGR209C TRX2 hom Verified 0.781937679348578 0.217125599895986 no 1068 0.192786930183392 633 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|RESPONSE TO OXIDATIVE STRESS ENDOMEMBRANE SYSTEM|NUCLEUS|GOLGI APPARATUS Cytoplasmic thioredoxin isoenzyme; part of the thioredoxin system which protects cells against oxidative and reductive stress; forms LMA1 complex with Pbi2p; acts as a cofactor for Tsa1p; required for ER-Golgi transport and vacuole inheritance; protein abundance increases in response to DNA replication stress vacuole inheritance|regulation of DNA replication|cell redox homeostasis|protein deglutathionylation|sulfate assimilation|retrograde vesicle-mediated transport, Golgi to ER|cellular response to oxidative stress|ER to Golgi vesicle-mediated transport|vacuole fusion, non-autophagic disulfide oxidoreductase activity cytosol|fungal-type vacuole
YOR171C YOR171C LCB4 hom Verified 0.781351185574632 0.217297986474482 no 1069 0.193170473731653 657 NA FT LIPID METABOLISM|SIGNALING|PROTEIN PHOSPHORYLATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS|PLASMA MEMBRANE Sphingoid long-chain base kinase, responsible for synthesis of long-chain base phosphates, which function as signaling molecules, regulates synthesis of ceramide from exogenous long-chain bases, localizes to the Golgi and late endosomes calcium-mediated signaling|sphingolipid metabolic process D-erythro-sphingosine kinase activity Golgi apparatus|endoplasmic reticulum|plasma membrane|cortical endoplasmic reticulum
YOR003W YOR003W YSP3 hom Verified 0.780465581001349 0.217558439637338 no 1070 0.20077926599479 684 NA FT PROTEOLYSIS Putative precursor to the subtilisin-like protease III protein catabolic process peptidase activity cellular_component
YPR140W YPR140W TAZ1 hom Verified 0.779662063811242 0.217794907012948 no 1071 0.215633389169734 716 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|LIPID METABOLISM|MEMBRANE ORGANIZATION|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Lyso-phosphatidylcholine acyltransferase, required for normal phospholipid content of mitochondrial membranes; may remodel acyl groups of cardiolipin in the inner membrane; human ortholog tafazzin is implicated in Barth syndrome cardiolipin acyl-chain remodeling|mitochondrial ATP synthesis coupled electron transport|protein complex assembly|inner mitochondrial membrane organization|cardiolipin metabolic process|phospholipid biosynthetic process 1-acylglycerophosphocholine O-acyltransferase activity mitochondrial outer membrane|mitochondrion|mitochondrial inner membrane|integral to mitochondrial outer membrane
YKL221W YKL221W MCH2 hom Verified 0.777972339104406 0.218292660128716 no 1072 0.233339106519856 765 NA Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport transport monocarboxylic acid transmembrane transporter activity|transporter activity integral to membrane|membrane
YJR020W_d YJR020W YJR020W hom Dubious 0.777939097551836 0.218302458876435 no 1073 0.202617710380151 710 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YLR209C YLR209C PNP1 hom Verified 0.776821345279284 0.218632090747692 no 1074 0.229707099066276 778 NA FT NUCLEOTIDE METABOLISM|COFACTOR METABOLISM Purine nucleoside phosphorylase, specifically metabolizes inosine and guanosine nucleosides; involved in the nicotinamide riboside salvage pathway guanosine catabolic process|inosine catabolic process|NAD biosynthesis via nicotinamide riboside salvage pathway|nicotinate nucleotide salvage nicotinamide riboside hydrolase activity|inosine nucleosidase activity|purine-nucleoside phosphorylase activity intracellular
YNL257C YNL257C SIP3 hom Verified 0.776256944920471 0.218798644616805 no 1075 0.252006690526408 859 NA FT TRANSCRIPTION FROM RNA POL II Transcription cofactor; acts through interaction with DNA-bound Snf1p; C-terminal region has a putative leucine zipper motif; potential Cdc28p substrate; SIP3 has a paralog, YSP1, that arose from the whole genome duplication positive regulation of transcription from RNA polymerase II promoter transcription cofactor activity integral to membrane
YDL011C_d YDL011C YDL011C hom Dubious 0.773319825597539 0.21966656272084 no 1076 0.205442397714481 693 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the uncharacterized ORF YDL010W Unknown Unknown Unknown
YGR079W_p YGR079W YGR079W hom Uncharacterized 0.772879071211499 0.219796975919034 no 1077 0.218302117356784 753 NA Putative protein of unknown function; YGR079W is not an essential gene biological_process molecular_function cellular_component
YPR071W_p YPR071W YPR071W hom Uncharacterized 0.772548730806359 0.219894748260709 no 1078 0.231064759284636 793 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Putative membrane protein; YPR071W is not an essential gene; YPR071W has paralog YIL029C biological_process molecular_function integral to membrane
YHR066W YHR066W SSF1 hom Verified 0.770905225461165 0.220381554803928 no 1079 0.203746093385974 708 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS NUCLEUS Constituent of 66S pre-ribosomal particles; required for ribosomal large subunit maturation; functionally redundant with Ssf2p; member of the Brix family; SSF1 has a paralog, SSF2, that arose from the whole genome duplication conjugation with cellular fusion|ribosomal large subunit assembly|regulation of cell size rRNA binding nucleolus
YER183C YER183C FAU1 hom Verified 0.770124491509508 0.220613024583643 no 1080 0.227339496469595 789 NA FT COFACTOR METABOLISM MITOCHONDRION 5,10-methenyltetrahydrofolate synthetase, involved in folic acid biosynthesis folic acid-containing compound biosynthetic process 5-formyltetrahydrofolate cyclo-ligase activity mitochondrion
YPL035C_d YPL035C YPL035C hom Dubious 0.769236364317405 0.220876503259964 no 1081 0.224788640253476 760 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YPL034W; YPL035C is not an essential gene Unknown Unknown Unknown
YOL140W YOL140W ARG8 hom Verified 0.767905972475128 0.221271524451233 no 1082 0.203565663776611 677 NA FT KETONE METABOLISM|AMINO ACID METABOLISM MITOCHONDRION Acetylornithine aminotransferase, catalyzes the fourth step in the biosynthesis of the arginine precursor ornithine arginine biosynthetic process|ornithine biosynthetic process N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity mitochondrion|mitochondrial matrix
YGL253W YGL253W HXK2 hom Verified 0.767899709660075 0.221273384967204 no 1083 0.2239333996966 769 NA FT CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS|GEN. OF PRECURSOR METABOLITES AND ENERGY NUCLEUS|MITOCHONDRION Hexokinase isoenzyme 2; catalyzes phosphorylation of glucose in the cytosol; predominant hexokinase during growth on glucose; functions in the nucleus to repress expression of HXK1 and GLK1 and to induce expression of its own gene; phosphorylation/dephosphorylation at serine-14 by protein kinase Snf1p and protein phosphatase Glc7p-Reg1p regulates nucleocytoplasmic shuttling of Hxk2p; HXK2 has a paralog, HXK1, that arose from the whole genome duplication replicative cell aging|fructose import|regulation of transcription by glucose|glucose import|mannose metabolic process|glycolysis|glucose metabolic process|regulation of cell size|fructose metabolic process hexokinase activity cytosol|mitochondrion|nucleus
YPL033C YPL033C SRL4 hom Verified 0.767561455225153 0.221373884664908 no 1084 0.209493650359597 692 NA FT NUCLEOTIDE METABOLISM Protein of unknown function; involved in regulation of dNTP production; null mutant suppresses the lethality of lcd1 and rad53 mutations; expression is induced by Kar4p deoxyribonucleoside triphosphate metabolic process molecular_function cellular_component
YJL182C_d YJL182C YJL182C hom Dubious 0.766672053952263 0.221638261609419 no 1085 0.221081368561023 756 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized ORF YJL181W Unknown Unknown Unknown
YKL215C YKL215C OXP1 hom Verified 0.766239399043343 0.221766934661404 no 1086 0.18882161125657 602 NA FT KETONE METABOLISM|AMINO ACID METABOLISM 5-oxoprolinase; enzyme is ATP-dependent and functions as a dimer; similar to mouse Oplah gene; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress glutathione metabolic process 5-oxoprolinase (ATP-hydrolyzing) activity cytoplasm
YLR266C YLR266C PDR8 hom Verified 0.76603695590392 0.221827156597128 no 1087 0.206609340751217 706 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Transcription factor; targets include ATP-binding cassette (ABC) transporters, major facilitator superfamily transporters, and other genes involved in the pleiotropic drug resistance (PDR) phenomenon; PDR8 has a paralog, YRR1, that arose from the whole genome duplication positive regulation of transcription from RNA polymerase II promoter in response to stress RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|sequence-specific DNA binding nucleus
YDR059C YDR059C UBC5 hom Verified 0.765232784142087 0.222066470468343 no 1088 0.221299205069961 725 NA Ubiquitin-conjugating enzyme; mediates selective degradation of short-lived, abnormal, or excess proteins, including histone H3; central component of the cellular stress response; expression is heat inducible; protein abundance increases in response to DNA replication stress; UBC5 has a paralog, UBC4, that arose from the whole genome duplication protein polyubiquitination|response to stress ubiquitin-protein ligase activity proteasome complex
YER181C_d YER181C YER181C hom Dubious 0.764104563284702 0.222402466571765 no 1089 0.214627143427722 752 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative data; extensively overlaps a Ty1 LTR; protein product is detected in highly purified mitochondria in high-throughput studies Unknown Unknown Unknown
YMR297W YMR297W PRC1 hom Verified 0.763325617512635 0.222634613972478 no 1090 0.184732569160388 642 NA FT PROTEOLYSIS ENDOPLASMIC RETICULUM Vacuolar carboxypeptidase Y (proteinase C; CPY), broad-specificity C-terminal exopeptidase involved in non-specific protein degradation in the vacuole; member of the serine carboxypeptidase family vacuolar protein catabolic process|phytochelatin biosynthetic process serine-type carboxypeptidase activity fungal-type vacuole lumen|endoplasmic reticulum|fungal-type vacuole|cytoplasm
YML060W YML060W OGG1 hom Verified 0.761584223667285 0.223154096820153 no 1091 0.220027231113332 765 NA FT RESPONSE TO DNA DAMAGE NUCLEUS|MITOCHONDRION Mitochondrial glycosylase/lyase that specifically excises 7,8-dihydro-8-oxoguanine residues located opposite cytosine or thymine residues in DNA, repairs oxidative damage to mitochondrial DNA, contributes to UVA resistance DNA repair|base-excision repair, AP site formation oxidized purine nucleobase lesion DNA N-glycosylase activity mitochondrion
YML083C YML083C YML083C hom Verified 0.757741425489495 0.224302897138497 no 1092 0.19987813578984 660 NA Protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; strong increase in transcript abundance during anaerobic growth compared to aerobic growth; cells deleted for YML083C do not exhibit growth defects in anerobic or anaerobic conditions biological_process molecular_function cellular_component
YNR008W YNR008W LRO1 hom Verified 0.756731020110962 0.224605513235105 no 1093 0.227859797534719 794 NA FT LIPID METABOLISM ENDOPLASMIC RETICULUM Acyltransferase that catalyzes diacylglycerol esterification; one of several acyltransferases that contribute to triglyceride synthesis; putative homolog of human lecithin cholesterol acyltransferase lipid storage|triglyceride biosynthetic process phospholipid:diacylglycerol acyltransferase activity lipid particle|perinuclear endoplasmic reticulum
YLR041W_d YLR041W YLR041W hom Dubious 0.756547240052891 0.224660580188848 no 1094 0.202992598189299 694 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YLR040C Unknown Unknown Unknown
YMR141C_d YMR141C YMR141C hom Dubious 0.755460663323351 0.224986313139627 no 1095 0.228562935822917 779 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YML086C YML086C ALO1 hom Verified 0.755324988022121 0.225027004542809 no 1096 0.200118412384124 662 NA FT OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS MITOCHONDRION D-Arabinono-1,4-lactone oxidase, catalyzes the final step in biosynthesis of dehydro-D-arabinono-1,4-lactone, which is protective against oxidative stress cellular response to oxidative stress|dehydro-D-arabinono-1,4-lactone biosynthetic process D-arabinono-1,4-lactone oxidase activity mitochondrial outer membrane|mitochondrion|integral to mitochondrial outer membrane
YNL046W_p YNL046W YNL046W hom Uncharacterized 0.754765044701293 0.225194985485837 no 1097 0.20858422092819 691 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Putative protein of unknown function; expression depends on Swi5p; GFP-fusion protein localizes to the endoplasmic reticulum; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) biological_process molecular_function endoplasmic reticulum
YMR034C_p YMR034C YMR034C hom Uncharacterized 0.753451637071895 0.225589281536014 no 1098 0.234628436578902 766 NA Putative transporter, member of the SLC10 carrier family; identified in a transposon mutagenesis screen as a gene involved in azole resistance; YMR034C is not an essential gene biological_process sterol transporter activity integral to membrane
YNL242W YNL242W ATG2 hom Verified 0.751711643096967 0.226112243523167 no 1099 0.216794581764155 730 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS|PEROXISOME ORGANIZATION Peripheral membrane protein required for autophagic vesicle formation; also required for vesicle formation during pexophagy and the cytoplasm-to-vaucole targeting (Cvt) pathway; involved in Atg9p cycling between the phagophore assembly site and mitochondria; forms cytoplasmic foci upon DNA replication stress mitochondrion degradation|piecemeal microautophagy of nucleus|peroxisome degradation|CVT pathway|autophagic vacuole assembly molecular_function pre-autophagosomal structure|cytoplasm|extrinsic to membrane
YDL188C YDL188C PPH22 hom Verified 0.750870133497099 0.226365408124702 no 1100 0.225375283627903 737 NA FT CELL CYCLE|TRANSLATION|CELL DIVISION|CYTOSKELETON ORGANIZATION NUCLEUS|CHROMOSOME Catalytic subunit of protein phosphatase 2A (PP2A); functionally redundant with Pph21p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis; protein abundance increases in response to DNA replication stress; PPH22 has a paralog, PPH21, that arose from the whole genome duplication actin filament organization|budding cell bud growth|G1/S transition of mitotic cell cycle|protein dephosphorylation|mitotic cell cycle spindle assembly checkpoint|regulation of translation protein serine/threonine phosphatase activity condensed nuclear chromosome, centromeric region
YKR080W YKR080W MTD1 hom Verified 0.750704519522992 0.226415251235318 no 1101 0.237414523420851 785 NA FT OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM NUCLEUS NAD-dependent 5,10-methylenetetrahydrafolate dehydrogenase, plays a catalytic role in oxidation of cytoplasmic one-carbon units; expression is regulated by Bas1p and Bas2p, repressed by adenine, and may be induced by inositol and choline folic acid-containing compound biosynthetic process|one-carbon metabolic process|purine nucleobase biosynthetic process methylenetetrahydrofolate dehydrogenase (NAD+) activity cytosol
YLR173W_p YLR173W YLR173W hom Uncharacterized 0.75028921551637 0.22654026820527 no 1102 0.229439883046261 770 NA Putative protein of unknown function biological_process molecular_function cellular_component
YJL180C YJL180C ATP12 hom Verified 0.750076719646721 0.226604249884144 no 1103 0.228892163607515 793 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Conserved protein required for assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase; mutation of human ATP12 reduces active ATP synthase levels and is associated with the disorder ATPAF2 deficiency mitochondrial proton-transporting ATP synthase complex assembly protein domain specific binding mitochondrion
YKL185W YKL185W ASH1 hom Verified 0.74963467872054 0.22673737935894 no 1104 0.185206624803215 654 NA FT CHROMATIN ORGANIZATION NUCLEUS|CHROMOSOME Zinc-finger inhibitor of HO transcription; mRNA is localized and translated in the distal tip of anaphase cells, resulting in accumulation of Ash1p in daughter cell nuclei and inhibition of HO expression; potential Cdc28p substrate Unknown RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|core promoter proximal region sequence-specific DNA binding Rpd3L-Expanded complex|nucleus|cellular bud|Rpd3L complex
YOL029C_p YOL029C YOL029C hom Uncharacterized 0.749563532995417 0.226758810440917 no 1105 0.21390111121629 756 NA Putative protein of unknown function; identified as interacting with Hsc82p and Hsp82p in high-throughput two-hybrid screens biological_process molecular_function cellular_component
YGR081C YGR081C SLX9 hom Verified 0.748439886189225 0.22709743581832 no 1106 0.242092809385677 846 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Protein required for pre-rRNA processing; associated with the 90S pre-ribosome and 43S small ribosomal subunit precursor; interacts with U3 snoRNA; deletion mutant has synthetic fitness defect with an sgs1 deletion mutant maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) molecular_function preribosome, small subunit precursor|nucleolus|nucleus|90S preribosome
YDL107W YDL107W MSS2 hom Verified 0.748088184609979 0.227203484151224 no 1107 0.230893315366968 807 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Peripherally bound inner membrane protein of the mitochondrial matrix involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18p protein insertion into mitochondrial membrane from inner side molecular_function extrinsic to mitochondrial inner membrane|mitochondrial matrix
YOR108W YOR108W LEU9 hom Verified 0.747461659898489 0.227392468841828 no 1108 0.21399839466618 733 NA FT KETONE METABOLISM|AMINO ACID METABOLISM MITOCHONDRION Alpha-isopropylmalate synthase II (2-isopropylmalate synthase); catalyzes the first step in the leucine biosynthesis pathway; the minor isozyme, responsible for the residual alpha-IPMS activity detected in a leu4 null mutant; LEU9 has a paralog, LEU4, that arose from the whole genome duplication leucine biosynthetic process 2-isopropylmalate synthase activity mitochondrion
YEL005C YEL005C VAB2 hom Verified 0.746184271866563 0.227778053909681 no 1109 0.225924604269501 757 NA Protein with a potential role in vacuolar function, as suggested by its ability to bind Vac8p; likely member of BLOC complex involved in endosomal cargo sorting; Vab2p-GFP-fusion localizes to cytoplasm in punctate patter biological_process molecular_function cytoplasm
YER155C YER155C BEM2 hom Verified 0.745703642734979 0.227923229097544 no 1110 0.237670285448804 791 NA FT SIGNALING|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION MITOCHONDRION|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE Rho GTPase activating protein (RhoGAP) involved in the control of cytoskeleton organization and cellular morphogenesis; required for bud emergence negative regulation of Rho protein signal transduction|fungal-type cell wall organization|establishment of cell polarity|actin cytoskeleton organization Rho GTPase activator activity cell cortex|incipient cellular bud site|mitochondrion|plasma membrane|mating projection tip|cytoplasm|cellular bud tip
YDR034C YDR034C LYS14 hom Verified 0.745699916624809 0.227924354781413 no 1111 0.232156588944125 769 NA FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS Transcriptional activator involved in regulation of genes of the lysine biosynthesis pathway; requires 2-aminoadipate semialdehyde as co-inducer Unknown|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus
YKR066C YKR066C CCP1 hom Verified 0.745115779653049 0.228100865309967 no 1112 0.23171979500278 778 NA FT OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS MITOCHONDRION Mitochondrial cytochrome-c peroxidase; degrades reactive oxygen species in mitochondria, involved in the response to oxidative stress cellular response to oxidative stress cytochrome-c peroxidase activity mitochondrion|mitochondrial intermembrane space
YML030W YML030W RCF1 hom Verified 0.74496265689934 0.228147147612787 no 1113 0.225494918164416 800 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Cytochrome c oxidase subunit; required for assembly of the Complex III-Complex IV supercomplex, and for assembly of Cox13p and Rcf2p into cytochrome c oxidase; similar to Rcf2p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; required for growth under hypoxic conditions; member of the hypoxia induced gene family; C. elegans and human orthologs are functional in yeast mitochondrial respiratory chain complex IV assembly|mitochondrial respiratory chain supercomplex assembly molecular_function mitochondrion|mitochondrial respiratory chain supercomplex|integral to mitochondrial inner membrane|mitochondrial respiratory chain complex IV
YPR124W YPR124W CTR1 hom Verified 0.743303612379802 0.228648942517356 no 1114 0.335048488998152 1135 NA FF|FT ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE High-affinity copper transporter of the plasma membrane; mediates nearly all copper uptake under low copper conditions; transcriptionally induced at low copper levels and degraded at high copper levels; protein increases in abundance and relocalizes from nucleus to plasma membrane upon DNA replication stress copper ion import copper uptake transmembrane transporter activity integral to membrane|plasma membrane
YBR272C YBR272C HSM3 hom Verified 0.743153620871784 0.228694339505272 no 1115 0.216197210049692 733 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RESPONSE TO DNA DAMAGE NUCLEUS Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); involved in DNA mismatch repair during slow growth; weak similarity to Msh1p; related to human 19S subunit S5b; structural study suggests Hsm3p is a scaffold protein for Rpt1p-Rpt2p complex formation mismatch repair|proteasome regulatory particle assembly molecular_function cytosol|proteasome regulatory particle, base subcomplex|nucleus|cytoplasm
YLR231C YLR231C BNA5 hom Verified 0.741812971321384 0.229100330194053 no 1116 0.194503069282884 671 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM NUCLEUS Kynureninase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p de novo NAD biosynthetic process from tryptophan kynureninase activity nucleus|cytoplasm
YPR100W YPR100W MRPL51 hom Verified 0.741512338996892 0.229191426542709 no 1117 0.261327141625204 881 NA FT TRANSLATION|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit mitochondrial translation|aerobic respiration structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YFR044C YFR044C DUG1 hom Verified 0.741303056305659 0.229254854498452 no 1118 0.234069351948641 817 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|PROTEOLYSIS MITOCHONDRION Cys-Gly metallo-di-peptidase; forms a complex with Dug2p and Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p) glutathione catabolic process metallodipeptidase activity|omega peptidase activity mitochondrion|ribosome|cytoplasm
YNL289W YNL289W PCL1 hom Verified 0.740724586090468 0.229430224454655 no 1119 0.232156011757334 792 NA FT CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS NUCLEUS Cyclin, interacts with cyclin-dependent kinase Pho85p; member of the Pcl1,2-like subfamily, involved in the regulation of polarized growth and morphogenesis and progression through the cell cycle; is ubiquitinated by Dma1p; phosphorylation by Pho85p targets it for degradation; localizes to sites of polarized cell growth regulation of establishment or maintenance of cell polarity|G1 phase of mitotic cell cycle|regulation of cyclin-dependent protein kinase activity|septin ring organization|positive regulation of macroautophagy cyclin-dependent protein kinase regulator activity cyclin-dependent protein kinase holoenzyme complex|incipient cellular bud site|nucleus
YLR046C_p YLR046C YLR046C hom Uncharacterized 0.740320490786832 0.229552775225376 no 1120 0.21475788355029 724 NA Putative membrane protein; member of the fungal lipid-translocating exporter (LTE) family of proteins; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance biological_process molecular_function integral to membrane
YLR070C YLR070C XYL2 hom Verified 0.739851322321413 0.229695106860514 no 1121 0.235413420050036 775 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM Xylitol dehydrogenase, converts xylitol to D-xylulose; expression induced by xylose, even though this pentose sugar is not well utilized by S. cerevisiae; null mutant has cell wall defect xylulose biosynthetic process D-xylulose reductase activity cellular_component
YPL185W_d YPL185W YPL185W hom Dubious 0.73972595005515 0.229733149411458 no 1122 0.238144631737628 782 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene UIP4/YPL186C Unknown Unknown Unknown
YOL030W YOL030W GAS5 hom Verified 0.739604512619904 0.229770001354041 no 1123 0.227252370217109 778 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM 1,3-beta-glucanosyltransferase, has similarity to Gas1p; localizes to the cell wall (1->3)-beta-D-glucan metabolic process 1,3-beta-glucanosyltransferase activity fungal-type cell wall|integral to membrane
YLR030W_p YLR030W YLR030W hom Uncharacterized 0.739302746165697 0.229861591072164 no 1124 0.209839181475676 718 NA Putative protein of unknown function biological_process molecular_function cellular_component
YAL056C-A_d YAL056C-A YAL056C-A hom Dubious 0.73822450261192 0.230189017786014 no 1125 0.249117734469164 839 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YNL301C YNL301C RPL18B hom Verified 0.737418242344202 0.230434022602333 no 1126 0.209972694860027 722 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L18B; homologous to mammalian ribosomal protein L18, no bacterial homolog; RPL18B has a paralog, RPL18A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YJL169W_d YJL169W YJL169W hom Dubious 0.737172767242856 0.230508646041579 no 1127 0.215271187467458 747 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL168C/SET2 Unknown Unknown Unknown
YDR070C YDR070C FMP16 hom Verified 0.737167265993848 0.230510318553781 no 1128 0.214722902174671 767 NA FT MITOCHONDRION Protein of unknown function; may be involved in responding to conditions of stress; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress biological_process molecular_function mitochondrion
YOL150C_d YOL150C YOL150C hom Dubious 0.737160271370913 0.230512445097422 no 1129 0.218759376389974 743 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YDR246W-A_p YDR246W-A YDR246W-A hom Uncharacterized 0.736544746235928 0.230699623358616 no 1130 0.217132045172526 740 NA Putative protein of unknown function; identified by fungal homology and RT-PCR biological_process molecular_function cellular_component
YAR027W YAR027W UIP3 hom Verified 0.736494745674828 0.230714832018974 no 1131 0.226858820284366 729 NA FT ENDOMEMBRANE SYSTEM|NUCLEUS|PLASMA MEMBRANE Putative integral membrane protein of unknown function; interacts with Ulp1p at the nuclear periphery; member of DUP240 gene family biological_process molecular_function nuclear envelope
YPR076W_d YPR076W YPR076W hom Dubious 0.73574889869207 0.230941762620332 no 1132 0.244752497598649 842 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YOL014W_p YOL014W YOL014W hom Uncharacterized 0.735632701263627 0.230977127941206 no 1133 0.257566382257903 893 NA Putative protein of unknown function biological_process molecular_function cellular_component
YEL018W YEL018W EAF5 hom Verified 0.735072961737939 0.231147530070509 no 1134 0.24766190466168 857 NA FT CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE NUCLEUS HISTONE ACETYLTRANSFERASE Esa1p-associated factor, non-essential subunit of the NuA4 acetyltransferase complex DNA repair molecular_function nucleus|NuA4 histone acetyltransferase complex
YKR020W YKR020W VPS51 hom Verified 0.734632668664837 0.231281618259931 no 1135 0.268049337342541 910 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL DIVISION|VACUOLAR TRANSPORT GOLGI APPARATUS Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; links the (VFT/GARP) complex to the SNARE Tlg1p vesicle organization|retrograde transport, endosome to Golgi|budding cell apical bud growth|regulation of cell size|protein targeting to vacuole protein binding Golgi apparatus|GARP complex
YJL158C YJL158C CIS3 hom Verified 0.733985635724027 0.231478746345815 no 1136 0.213708463578254 718 NA FT CELL WALL ORG/BIOGENESIS ENDOPLASMIC RETICULUM|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE Mannose-containing glycoprotein constituent of the cell wall; member of the PIR (proteins with internal repeats) family fungal-type cell wall organization structural constituent of cell wall extracellular region|fungal-type cell wall|endoplasmic reticulum|plasma membrane|cellular bud tip
YMR174C YMR174C PAI3 hom Verified 0.733716239448857 0.231560849489249 no 1137 0.220396058847413 754 NA Cytoplasmic proteinase A (Pep4p) inhibitor, dependent on Pbs2p and Hog1p protein kinases for osmotic induction; intrinsically unstructured, N-terminal half becomes ordered in the active site of proteinase A upon contact vacuolar protein catabolic process endopeptidase inhibitor activity cytoplasm
YJR096W YJR096W YJR096W hom Verified 0.733390534205416 0.231660135431269 no 1138 0.225563127242865 786 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|RESPONSE TO OXIDATIVE STRESS NUCLEUS Putative xylose and arabinose reductase; member of the aldo-keto reductase (AKR) family; GFP-fusion protein is induced in response to the DNA-damaging agent MMS cellular response to oxidative stress|D-xylose catabolic process|arabinose catabolic process alditol:NADP+ 1-oxidoreductase activity|aldo-keto reductase (NADP) activity nucleus|cytoplasm
YDR080W YDR080W VPS41 hom Verified 0.73272124920572 0.23186423051172 no 1139 0.233614997669159 801 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|VACUOLAR PROTEIN PROCESSING Vacuolar membrane protein that is a subunit of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex; essential for membrane docking and fusion at the Golgi-to-endosome and endosome-to-vacuole stages of protein transport regulation of SNARE complex assembly|regulation of vacuole fusion, non-autophagic|piecemeal microautophagy of nucleus|vacuole organization|vesicle-mediated transport|protein transport|vacuole fusion, non-autophagic|vacuolar protein processing Rab guanyl-nucleotide exchange factor activity|phosphatidylinositol binding endosome|fungal-type vacuole membrane|HOPS complex
YHR176W YHR176W FMO1 hom Verified 0.732435122954655 0.231951513817516 no 1140 0.232173650724927 801 NA FT OXIDATION-REDUCTION PROCESS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Flavin-containing monooxygenase, localized to the cytoplasmic face of the ER membrane; catalyzes oxidation of biological thiols to maintain the ER redox buffer ratio for correct folding of disulfide-bonded proteins protein folding N,N-dimethylaniline monooxygenase activity endoplasmic reticulum membrane
YBR047W_p YBR047W FMP23 hom Uncharacterized 0.732026302975533 0.232076256798122 no 1141 0.22639453653047 785 NA FT MITOCHONDRION Putative protein of unknown function; proposed to be involved in iron or copper homeostasis; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process molecular_function mitochondrion
YOL067C YOL067C RTG1 hom Verified 0.731943950425652 0.23210138949779 no 1142 0.259190456953058 882 NA FT TRANSCRIPTION FROM RNA POL II|SIGNALING NUCLEUS Transcription factor (bHLH) involved in interorganelle communication between mitochondria, peroxisomes, and nucleus cellular response to oleic acid|positive regulation of transcription from RNA polymerase II promoter|mitochondria-nucleus signaling pathway sequence-specific DNA binding RNA polymerase II transcription factor activity nucleus|cytoplasm
YHR202W_p YHR202W YHR202W hom Uncharacterized 0.731823056389072 0.232138287195869 no 1143 0.232922527063969 834 NA FT NUCLEOTIDE METABOLISM Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole, while HA-tagged protein is found in the soluble fraction, suggesting cytoplasmic localization biological_process molecular_function cytosol|fungal-type vacuole
YHR204W YHR204W MNL1 hom Verified 0.731088820965055 0.232362451050783 no 1144 0.227701587970409 816 NA FT PROTEOLYSIS ENDOPLASMIC RETICULUM Alpha-1,2-specific exomannosidase of the endoplasmic reticulum; in complex with Pdi1p, generates a Man7GlcNac2 oligosaccharide signal on glycoproteins destined for ubiquitin-proteasome degradation ER-associated protein catabolic process carbohydrate binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity endoplasmic reticulum lumen
YDR019C YDR019C GCV1 hom Verified 0.730948351736313 0.232405350364644 no 1145 0.246651505279768 879 NA FT KETONE METABOLISM|AMINO ACID METABOLISM MITOCHONDRION T subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of levels of 5,10-methylene-THF in the cytoplasm glycine catabolic process|glycine metabolic process|one-carbon metabolic process glycine dehydrogenase (decarboxylating) activity mitochondrion|glycine cleavage complex
YDR453C YDR453C TSA2 hom Verified 0.730886160633155 0.232424344939462 no 1146 0.214399159524144 712 NA FT OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS Stress inducible cytoplasmic thioredoxin peroxidase; cooperates with Tsa1p in the removal of reactive oxygen, nitrogen and sulfur species using thioredoxin as hydrogen donor; deletion enhances the mutator phenotype of tsa1 mutants; protein abundance increases in response to DNA replication stress cellular response to oxidative stress|cell redox homeostasis peroxiredoxin activity|thioredoxin peroxidase activity cytoplasm
YBL089W YBL089W AVT5 hom Verified 0.72828792619799 0.233218675849916 no 1147 0.262604516277041 871 NA Putative transporter; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters; AVT5 has a paralog, AVT6, that arose from the whole genome duplication transport transporter activity integral to membrane
YCL057W YCL057W PRD1 hom Verified 0.72724071230163 0.233539255087719 no 1148 0.226418616310457 798 NA FT PROTEOLYSIS MITOCHONDRION Zinc metalloendopeptidase; found in the cytoplasm and intermembrane space of mitochondria; with Cym1p, involved in degradation of mitochondrial proteins and of presequence peptides cleaved from imported proteins; protein abundance increases in response to DNA replication stress proteolysis metalloendopeptidase activity mitochondrion|cytoplasm|mitochondrial intermembrane space
YDR440W YDR440W DOT1 hom Verified 0.725744538379576 0.233997696299662 no 1149 0.237252027801004 830 NA FT CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING NUCLEUS Nucleosomal histone H3-Lys79 methylase; methylation is required for telomeric silencing, meiotic checkpoint control, and DNA damage response meiotic recombination checkpoint|postreplication repair|recombinational repair|global genome nucleotide-excision repair|nucleotide-excision repair|DNA damage checkpoint|chromatin silencing at telomere|histone H3-K79 methylation nucleosomal histone binding|histone methyltransferase activity (H3-K79 specific) nucleus
YDR497C YDR497C ITR1 hom Verified 0.725596959901648 0.234042942673752 no 1150 0.219212962693989 731 NA FT PLASMA MEMBRANE Myo-inositol transporter; has strong similarity to the minor myo-inositol transporter Itr2p, member of the sugar transporter superfamily; expression is repressed by inositol and choline via Opi1p and derepressed via Ino2p and Ino4p; relative distribution to the vacuole increases upon DNA replication stress myo-inositol transport|transmembrane transport myo-inositol transmembrane transporter activity integral to membrane|plasma membrane|membrane
YHR191C YHR191C CTF8 hom Verified 0.72476408352494 0.234298386692874 no 1151 0.284773695750926 950 NA FT CELL CYCLE|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME Subunit of a complex with Ctf18p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion maintenance of DNA trinucleotide repeats|mitotic sister chromatid cohesion molecular_function Ctf18 RFC-like complex
YLR252W_d YLR252W YLR252W hom Dubious 0.724127116560568 0.234493849191475 no 1152 0.249007286562081 829 NA Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene SYM1, a mitochondrial protein involved in ethanol metabolism Unknown Unknown Unknown
YOR124C YOR124C UBP2 hom Verified 0.723042168754257 0.234826988663071 no 1153 0.224846663466194 789 NA FT PROTEOLYSIS Ubiquitin-specific protease that removes ubiquitin from ubiquitinated proteins; interacts with Rsp5p and is required for MVB sorting of membrane proteins; can cleave polyubiquitin and has isopeptidase activity protein deubiquitination|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway ubiquitin-specific protease activity cytoplasm
YLL001W YLL001W DNM1 hom Verified 0.723038515308228 0.234828110916483 no 1154 0.219607425520279 746 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION|PEROXISOME ORGANIZATION MITOCHONDRION Dynamin-related GTPase required for mitochondrial fission and morphology; assembles on the cytoplasmic face of mitochondrial tubules at sites at which division will occur; also participates in endocytosis and regulating peroxisome abundance mitochondrion inheritance|peroxisome fission|mitochondrial fission|chronological cell aging|peroxisome organization|mitochondrion organization|protein homooligomerization protein homodimerization activity|GTPase activity|identical protein binding mitochondrial outer membrane|mitochondrion|peroxisome
YOR109W YOR109W INP53 hom Verified 0.722720436869376 0.234925828558072 no 1155 0.22833544791046 790 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|MEMBRANE ORGANIZATION CYTOSKELETON Polyphosphatidylinositol phosphatase, dephosphorylates multiple phosphatidylinositols; involved in trans Golgi network-to-early endosome pathway; hyperosmotic stress causes translocation to actin patches; contains Sac1 and 5-ptase domains phosphatidylinositol dephosphorylation phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|phosphatidylinositol-3-phosphatase activity|phosphatidylinositol-4-phosphate phosphatase activity membrane|actin cortical patch|cytoplasm
YFL044C YFL044C OTU1 hom Verified 0.722379099128581 0.235030716735962 no 1156 0.207549983222677 700 NA FT PROTEOLYSIS NUCLEUS Deubiquitylation enzyme that binds to the chaperone-ATPase Cdc48p; may contribute to regulation of protein degradation by deubiquitylating substrates that have been ubiquitylated by Ufd2p; member of the Ovarian Tumor (OTU) family; protein abundance increases in response to DNA replication stress protein deubiquitination|regulation of transcription, DNA-dependent ubiquitin-specific protease activity nucleus|cytoplasm
YKL085W YKL085W MDH1 hom Verified 0.721373911656693 0.235339746607665 no 1157 0.241152887797905 810 NA FT KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION Mitochondrial malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the tricarboxylic acid (TCA) cycle; phosphorylated chronological cell aging|replicative cell aging|tricarboxylic acid cycle|aerobic respiration L-malate dehydrogenase activity|mRNA binding mitochondrion|mitochondrial matrix
YLR395C YLR395C COX8 hom Verified 0.720856371293053 0.235498944089756 no 1158 0.251583032656745 869 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Subunit VIII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain mitochondrial electron transport, cytochrome c to oxygen cytochrome-c oxidase activity mitochondrion|integral to membrane|mitochondrial respiratory chain complex IV
YKR076W YKR076W ECM4 hom Verified 0.719850856997368 0.235808414105703 no 1159 0.24177124313609 824 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|CELL WALL ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS Omega class glutathione transferase; not essential; similar to Ygr154cp; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm fungal-type cell wall organization|glutathione metabolic process glutathione transferase activity cytoplasm
YMR154C YMR154C RIM13 hom Verified 0.719585592246745 0.235890092759327 no 1160 0.243053218834879 830 NA FF|FT ION HOMEOSTASIS|PROTEOLYSIS|ION HOMEOSTASIS Calpain-like cysteine protease; involved in proteolytic activation of Rim101p in response to alkaline pH; localizes to punctate structures in alkaline conditions and in vps4 mutant; has similarity to A. nidulans palB protein processing cysteine-type endopeptidase activity cellular_component
YPR116W YPR116W RRG8 hom Verified 0.719547278226223 0.235901891460315 no 1161 0.232637817734535 795 NA FT MITOCHONDRION ORGANIZATION MITOCHONDRION Putative protein of unknown function, required for mitochondrial genome maintenance; null mutation results in a decrease in plasma membrane electron transport mitochondrial genome maintenance molecular_function mitochondrion
YKL084W YKL084W HOT13 hom Verified 0.719022241036868 0.236063608036853 no 1162 0.235954287925246 821 NA FT PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Zinc-binding mitochondrial intermembrane space (IMS) protein involved in a disulfide relay system for IMS import of cysteine-containing proteins; binds Mia40p and stimulates its Erv1p-dependent oxidation, probably by sequestering zinc protein import into mitochondrial intermembrane space zinc ion binding mitochondrial intermembrane space
YER046W YER046W SPO73 hom Verified 0.718320501456397 0.236279846015493 no 1163 0.224487345654189 750 NA FT CELL WALL ORG/BIOGENESIS Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensible for both nuclear divisions during meiosis ascospore wall assembly|ascospore formation molecular_function cytosol
YCR087W_d YCR087W YCR087W hom Dubious 0.716532731992763 0.236831231922152 no 1164 0.261483590269845 913 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized gene YCR087C-A; YCR087W is not an essential gene Unknown Unknown Unknown
YCR011C YCR011C ADP1 hom Verified 0.715248313523534 0.237227810085434 no 1165 0.217601257126951 758 NA FT NUCLEOTIDE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Putative ATP-dependent permease of the ABC transporter family of proteins transport|transmembrane transport ATPase activity, coupled to transmembrane movement of substances integral to membrane|endoplasmic reticulum|cytoplasm
YPL116W YPL116W HOS3 hom Verified 0.714994280782934 0.237306288639383 no 1166 0.21446983335869 723 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION NUCLEUS|SITE OF POLARIZED GROWTH Trichostatin A-insensitive homodimeric histone deacetylase (HDAC) with specificity in vitro for histones H3, H4, H2A, and H2B; similar to Hda1p, Rpd3p, Hos1p, and Hos2p; deletion results in increased histone acetylation at rDNA repeats regulation of transcription involved in G1/S phase of mitotic cell cycle|positive regulation of transcription from RNA polymerase II promoter|histone deacetylation histone deacetylase activity nucleus|cellular bud neck|cytoplasm
YKL201C YKL201C MNN4 hom Verified 0.714612208557644 0.237424349385158 no 1167 0.232766284728964 761 NA FT CARBOHYDRATE METABOLISM Putative positive regulator of mannosylphosphate transferase Mnn6p; involved in mannosylphosphorylation of N-linked oligosaccharides; expression increases in late-logarithmic and stationary growth phases; MNN4 has a paralog, YJR061W, that arose from the whole genome duplication protein O-linked glycosylation|protein N-linked glycosylation|response to stress molecular_function membrane
YOR223W YOR223W YOR223W hom Verified 0.714146779199637 0.237568211134134 no 1168 0.23681475065197 788 NA FT ENDOPLASMIC RETICULUM Subunit of the DSC ubiquitin ligase complex; protein of unknown function that localizes to the ER and vacuole lumen; overexpression affects endocytic protein trafficking; ortholog of fission yeast dsc3 biological_process molecular_function fungal-type vacuole lumen|endoplasmic reticulum
YGL226W YGL226W MTC3 hom Verified 0.712576599181442 0.238053898200227 no 1169 0.226647530521816 776 NA FT MITOCHONDRION Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; mtc3 is synthetically sick with cdc13-1 biological_process molecular_function mitochondrion
YGL144C YGL144C ROG1 hom Verified 0.711201044937124 0.238479830578015 no 1170 0.246313226618484 812 NA FT LIPID METABOLISM Protein with putative serine active lipase domain; ROG1 has a paralog, YDL109C, that arose from the whole genome duplication cellular lipid metabolic process lipase activity cellular_component
YER005W YER005W YND1 hom Verified 0.711054155387464 0.23852533871642 no 1171 0.235759311073104 812 NA FT LIPID METABOLISM|CARBOHYDRATE METABOLISM GOLGI APPARATUS Apyrase with wide substrate specificity, helps prevent inhibition of glycosylation by hydrolyzing nucleoside tri- and diphosphates that inhibit glycotransferases; partially redundant with Gda1p; mediates adenovirus E4orf4-induced toxicity protein glycosylation nucleoside-triphosphatase activity|nucleoside-diphosphatase activity COPI-coated vesicle|Golgi apparatus|membrane|Golgi membrane
YMR007W_d YMR007W YMR007W hom Dubious 0.710399478709554 0.238728223174701 no 1172 0.199905302572121 686 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YIL154C YIL154C IMP2' hom Verified 0.710086256963365 0.238825324050334 no 1173 0.29520612721454 1045 NA FF|FT RESPONSE TO DNA DAMAGE|ION HOMEOSTASIS|CARBOHYDRATE METABOLISM|ION HOMEOSTASIS Transcriptional activator involved in maintenance of ion homeostasis and protection against DNA damage caused by bleomycin and other oxidants, contains a C-terminal leucine-rich repeat DNA repair|cellular carbohydrate metabolic process transcription coactivator activity cytoplasm
YPL229W_p YPL229W YPL229W hom Uncharacterized 0.709191702838648 0.239102760839045 no 1174 0.239815363418255 826 NA Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; not an essential gene; YPL229W has a paralog, YMR181C, that arose from the whole genome duplication biological_process molecular_function cytoplasm
YCL026C-B YCL026C-B HBN1 hom Verified 0.709039305475548 0.23915004287377 no 1175 0.250964678539559 869 NA FT OXIDATION-REDUCTION PROCESS NUCLEUS Protein of unknown function; similar to bacterial nitroreductases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; protein becomes insoluble upon intracellular iron depletion; protein abundance increases in response to DNA replication stress biological_process NAD(P)H nitroreductase activity nucleus|cytoplasm
YPL004C YPL004C LSP1 hom Verified 0.708811037462083 0.239220873710478 no 1176 0.226251557248311 774 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|PROTEIN PHOSPHORYLATION MITOCHONDRION Primary component of eisosomes, which are large immobile patch structures at the cell cortex associated with endocytosis, along with Pil1p and Sur7p; null mutants show activation of Pkc1p/Ypk1p stress resistance pathways; member of the BAR domain family negative regulation of protein kinase activity|endocytosis|response to heat lipid binding mitochondrial outer membrane|eisosome|mitochondrion|plasma membrane|cytoplasm
YPR158W YPR158W CUR1 hom Verified 0.708765149740281 0.239235113907879 no 1177 0.259467834627353 906 NA FT NUCLEUS Sorting factor, central regulator of spatial protein quality control; physically and functionally interacts with chaperones to promote sorting and deposition of misfolded proteins into cytosolic compartments; involved in destabilization of [URE3] prions; CUR1 has a paralog, BTN2, that arose from the whole genome duplication cellular response to stress|protein localization to nucleus chaperone binding nucleus
YCR067C YCR067C SED4 hom Verified 0.708068006790709 0.2394515131219 no 1178 0.237548277657284 775 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|NUCLEOTIDE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS Integral endoplasmic reticulum membrane protein that stimulates Sar1p GTPase activity; involved in COPII vesicle budding through disassociation of coat proteins from membranes onto liposomes; binds Sec16p; similar to Sec12p positive regulation of GTPase activity|regulation of COPII vesicle coating Sar GTPase activator activity integral to endoplasmic reticulum membrane
YBR283C YBR283C SSH1 hom Verified 0.707848251443951 0.239519749237359 no 1179 0.217370062269366 710 NA FT PROTEIN LOCALIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Subunit of the Ssh1 translocon complex; Sec61p homolog involved in co-translational pathway of protein translocation; not essential SRP-dependent cotranslational protein targeting to membrane protein transmembrane transporter activity|signal sequence binding integral to membrane|Ssh1 translocon complex
YDR389W YDR389W SAC7 hom Verified 0.70720792166163 0.239718638219457 no 1180 0.308936261865567 1069 NA FF|FT CELL CYCLE|SIGNALING|CYTOSKELETON ORGANIZATION CYTOSKELETON GTPase activating protein (GAP) for Rho1p, involved in signaling to the actin cytoskeleton, null mutations suppress tor2 mutations and temperature sensitive mutations in actin; potential Cdc28p substrate actin filament reorganization involved in cell cycle|small GTPase mediated signal transduction Rho GTPase activator activity intracellular
YCR028C-A YCR028C-A RIM1 hom Verified 0.707163751881299 0.239732360851109 no 1181 0.282541928744406 945 NA FT MITOCHONDRION ORGANIZATION MITOCHONDRION Single-stranded DNA-binding protein essential for mitochondrial genome maintenance; involved in mitochondrial DNA replication mitochondrial DNA replication|mitochondrial genome maintenance single-stranded DNA binding mitochondrial nucleoid|mitochondrion
YNL050C_p YNL050C YNL050C hom Uncharacterized 0.707131979239817 0.239742232214745 no 1182 0.245809850262767 840 NA Putative protein of unknown function; YNL050c is not an essential gene biological_process molecular_function cellular_component
YGL059W YGL059W PKP2 hom Verified 0.706679325310018 0.239882890233236 no 1183 0.240243110034708 824 NA FT CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION MITOCHONDRION Mitochondrial protein kinase; negatively regulates activity of the pyruvate dehydrogenase complex by phosphorylating the ser-133 residue of the Pda1p subunit; acts in concert with kinase Pkp1p and phosphatases Ptc5p and Ptc6p; relocalizes from mitochondrion to cytoplasm upon DNA replication stress peptidyl-serine phosphorylation|protein phosphorylation|carbon utilization|negative regulation of catalytic activity protein kinase activity|pyruvate dehydrogenase (acetyl-transferring) kinase activity mitochondrion
YMR310C_p YMR310C YMR310C hom Uncharacterized 0.705224582636683 0.240335242690672 no 1184 0.24303119255158 821 NA FT NUCLEUS Putative S-adenosylmethionine-dependent methyltransferase; predicted to be involved in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR310C is not an essential gene biological_process S-adenosylmethionine-dependent methyltransferase activity nucleus
YHR114W YHR114W BZZ1 hom Verified 0.704608465317921 0.240526964460177 no 1185 0.213443871816342 735 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH|CYTOSKELETON SH3 domain protein implicated in the regulation of actin polymerization, able to recruit actin polymerization machinery through its SH3 domains, colocalizes with cortical actin patches and Las17p, interacts with type I myosins response to salt stress|actin filament organization|endocytosis molecular_function mating projection tip|cytoplasm|actin cortical patch
YIR044C YIR044C YIR044C hom pseudogene 0.704324443227826 0.240615373744435 no 1186 0.243315470730962 818 NA Possible pseudogene in strain S288C; YIR044C and the adjacent ORF, YIR043C, together may encode a non-functional member of the conserved, often subtelomerically-encoded Cos protein family biological_process molecular_function cellular_component
YOR252W YOR252W TMA16 hom Verified 0.703771020689321 0.240787691751801 no 1187 0.229351184722081 780 NA FT NUCLEUS Protein of unknown function that associates with ribosomes biological_process molecular_function ribosome|nucleus
YJL206C_p YJL206C YJL206C hom Uncharacterized 0.703378708140434 0.240909885942868 no 1188 0.232953027135112 816 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Putative protein of unknown function; similar to transcriptional regulators from the Zn[2]-Cys[6] binuclear cluster protein family; mRNA is weakly cell cycle regulated, peaking in S phase; induced rapidly upon MMS treatment biological_process molecular_function cellular_component
YGL190C YGL190C CDC55 hom Verified 0.703187618425485 0.240969417163515 no 1189 0.331807004170683 1133 NA FT CELL CYCLE|SIGNALING NUCLEUS|SITE OF POLARIZED GROWTH Non-essential regulatory subunit B of protein phosphatase 2A (PP2A); localization to the cytoplasm requires Zds1p and Zds2p and promotes mitotic entry; localization to the nucleus prevents mitotic exit; required for correct nuclear division and chromosome segregation in meiosis; maintains nucleolar sequestration of Cdc14p during early meiosis; limits formation of PP2A-Rts1p holocomplexes to ensure timely dissolution of sister chromosome cohesion negative regulation of exit from mitosis|positive regulation of G2/M transition of mitotic cell cycle|cell shape checkpoint|protein dephosphorylation protein phosphatase type 2A regulator activity nucleus|cellular bud neck|cytoplasm|cellular bud tip
YLR338W_d YLR338W OPI9 hom Dubious 0.701867566554422 0.241380878571509 no 1190 0.293321176447874 1009 NA FF Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF VRP1/YLR337C Unknown Unknown Unknown
YBR007C YBR007C DSF2 hom Verified 0.701533389719775 0.241485102316447 no 1191 0.255472588459162 942 NA FF Deletion suppressor of mpt5 mutation; relocalizes from bud neck to cytoplasm upon DNA replication stress biological_process molecular_function cellular_component
YGL151W YGL151W NUT1 hom Verified 0.701163558964219 0.241600474364433 no 1192 0.237413502449178 832 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS|MITOCHONDRION Component of the RNA polymerase II mediator complex, which is required for transcriptional activation and also has a role in basal transcription regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter molecular_function mitochondrion|mediator complex|nucleus
YKL157W YKL157W APE2 hom Verified 0.700843040612374 0.241700487165277 no 1193 0.250182799737191 816 NA FT PROTEOLYSIS MITOCHONDRION Aminopeptidase yscII; may have a role in obtaining leucine from dipeptide substrates; APE2 has a paralog, AAP1, that arose from the whole genome duplication peptide catabolic process metalloaminopeptidase activity mitochondrion|extracellular region|cell wall-bounded periplasmic space
YJL215C_d YJL215C YJL215C hom Dubious 0.700400462465945 0.241838623771298 no 1194 0.253907283255499 847 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YBR259W YBR259W YBR259W hom Verified 0.700128221957765 0.241923616209277 no 1195 0.243755980483937 821 NA Protein of unknown function; YBR259W is not an essential gene; forms cytoplasmic foci upon DNA replication stress biological_process molecular_function cellular_component
YEL029C YEL029C BUD16 hom Verified 0.699975080679916 0.241971433446651 no 1196 0.281598785637465 974 NA FT CELL CYCLE|CELL DIVISION|COFACTOR METABOLISM NUCLEUS Putative pyridoxal kinase, a key enzyme involved in pyridoxal 5'-phosphate synthesis, the active form of vitamin B6; required for genome integrity; involved in bud-site selection; similarity to yeast BUD17 and human pyridoxal kinase (PDXK) pyridoxal phosphate biosynthetic process|cellular bud site selection pyridoxal kinase activity cytoplasm
YOR134W YOR134W BAG7 hom Verified 0.699030981814683 0.242266334560616 no 1197 0.242152646985501 849 NA FT SIGNALING Rho GTPase activating protein (RhoGAP), stimulates the intrinsic GTPase activity of Rho1p, which plays a role in actin cytoskeleton organization and control of cell wall synthesis; structurally and functionally related to Sac7p small GTPase mediated signal transduction Rho GTPase activator activity intracellular
YGL090W YGL090W LIF1 hom Verified 0.698451895706013 0.242447315704188 no 1198 0.244413489379463 849 NA FT RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME Component of the DNA ligase IV complex that mediates nonhomologous end joining in DNA double-strand break repair; physically interacts with Dnl4p and Nej1p; homologous to mammalian XRCC4 protein double-strand break repair via nonhomologous end joining chromatin binding DNA ligase IV complex|nuclear chromatin|nucleus
YHR086W-A_p YHR086W-A YHR086W-A hom Uncharacterized 0.698115148505314 0.242552592604868 no 1199 0.234772687734592 807 NA Putative protein of unknown function; identified by fungal homology and RT-PCR biological_process molecular_function cellular_component
YMR316C-A_p YMR316C-A YMR316C-A hom Uncharacterized 0.697423833389481 0.242768795235745 no 1200 0.23914034249403 830 NA Protein of unknown function; mRNA identified as translated by ribosome profiling data; overlaps the verified gene DIA1/YMR316W biological_process molecular_function cellular_component
YJL145W YJL145W SFH5 hom Verified 0.694195851821884 0.243779696844444 no 1201 0.21548960703484 760 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Non-classical phosphatidylinositol transfer protein (PITP); exhibits PI- but not PC-transfer activity; localizes to the peripheral endoplasmic reticulum, cytosol and microsomes; similar to Sec14p; partially relocalizes to the plasma membrane upon DNA replication stress Golgi to plasma membrane protein transport|phosphatidylinositol metabolic process|Unknown|regulation of exocytosis|phospholipid transport phosphatidylinositol transporter activity|phosphatidylcholine transporter activity cell periphery|cytosol|plasma membrane|cortical endoplasmic reticulum
YMR080C YMR080C NAM7 hom Verified 0.69400030254356 0.243841009593923 no 1202 0.261789675675302 881 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|RNA LOCALIZATION|GENE SILENCING NUCLEUS ATP-dependent RNA helicase of the SFI superfamily; involved in nonsense mediated mRNA decay; required for efficient translation termination at nonsense codons and targeting of NMD substrates to P-bodies; involved in telomere maintenance; forms cytoplasmic foci upon DNA replication stress nuclear-transcribed mRNA catabolic process|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay|intracellular mRNA localization|translational frameshifting|regulation of translational termination|chromatin silencing at silent mating-type cassette|protein ubiquitination RNA-dependent ATPase activity|ATP-dependent RNA helicase activity|nucleic acid binding mitochondrion|polysome|cytoplasm
YKL117W YKL117W SBA1 hom Verified 0.69289072804498 0.244189064410067 no 1203 0.227682780142554 730 NA FT NUCLEUS Co-chaperone that binds to and regulates Hsp90 family chaperones; important for pp60v-src activity in yeast; homologous to the mammalian p23 proteins, and like p23 can regulate telomerase activity; protein abundance increases in response to DNA replication stress protein folding|positive regulation of telomere maintenance via telomerase|regulation of telomerase activity chaperone binding nucleus|cytoplasm
YBR026C YBR026C ETR1 hom Verified 0.692840085237971 0.244204956594414 no 1204 0.273154232522779 893 NA FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION 2-enoyl thioester reductase, member of the medium chain dehydrogenase/reductase family; localized to in mitochondria, where it has a probable role in fatty acid synthesis fatty acid biosynthetic process|aerobic respiration enoyl-[acyl-carrier-protein] reductase activity mitochondrion
YJL016W_p YJL016W YJL016W hom Uncharacterized 0.692495978682157 0.244312955201281 no 1205 0.250520522995319 847 NA Putative protein of unknown function; GFP-fusion protein localizes to the cytoplasm; conserved in closely related Saccharomyces species biological_process molecular_function cytoplasm
YBR072C-A_p YBR072C-A YBR072C-A hom Uncharacterized 0.691700536156965 0.244562705109328 no 1206 0.240096943229115 804 NA Putative protein of unknown function; identified by fungal homology and RT-PCR biological_process molecular_function cellular_component
YPR148C YPR148C YPR148C hom Verified 0.689565228537674 0.245233820088741 no 1207 0.232861159520739 817 NA Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern biological_process molecular_function ribosome|cytoplasm
YMR247C YMR247C RKR1 hom Verified 0.688882576980597 0.245448582258051 no 1208 0.229077237700029 778 NA FT CHROMATIN ORGANIZATION|PROTEOLYSIS|GENE SILENCING NUCLEUS RING domain E3 ubiquitin ligase; involved in the ubiquitin-mediated degradation of non-stop proteins; functional connections to chromatin modification; nuclear protein that also co-localizes with ribosomes; homolog of mouse Listerin, whose mutation has been reported to cause neurodegeneration in mice chromatin modification|chromatin silencing at telomere|ubiquitin-dependent protein catabolic process|protein ubiquitination ubiquitin-protein ligase activity|ribosome binding ribosome|nucleus
YDL079C YDL079C MRK1 hom Verified 0.688118128553865 0.245689197619777 no 1209 0.235566746342735 796 NA FT PROTEIN PHOSPHORYLATION Glycogen synthase kinase 3 (GSK-3) homolog; one of four GSK-3 homologs in S. cerevisiae that function to activate Msn2p-dependent transcription of stress responsive genes and that function in protein degradation regulation of protein catabolic process|protein phosphorylation|response to stress protein serine/threonine kinase activity cellular_component
YDR296W YDR296W MHR1 hom Verified 0.687235455299288 0.245967182536718 no 1210 0.26531359042565 902 NA FT MITOCHONDRION ORGANIZATION|RESPONSE TO OXIDATIVE STRESS NUCLEUS|MITOCHONDRION Protein involved in homologous recombination in mitochondria; required for recombination-dependent mtDNA partitioning; involved in stimulation of mitochondrial DNA replication in response to oxidative stress cellular response to oxidative stress|positive regulation of mitochondrial DNA replication|regulation of transcription, DNA-dependent|mitochondrial genome maintenance|DNA recombination single-stranded DNA binding|recombinase activity|DNA binding mitochondrion|nucleus
YOL153C YOL153C YOL153C hom pseudogene 0.686209371683127 0.246290544435819 no 1211 0.212511223788383 702 NA Hypothetical protein biological_process molecular_function cellular_component
YIL135C YIL135C VHS2 hom Verified 0.686096755068474 0.246326048519133 no 1212 0.209567219505635 730 NA FT CELL CYCLE Cytoplasmic protein of unknown function; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; similar to Mlf3p G1/S transition of mitotic cell cycle molecular_function cytoplasm
YHR092C YHR092C HXT4 hom Verified 0.685927312734227 0.246379472935074 no 1213 0.205571497195896 701 NA FT PLASMA MEMBRANE High-affinity glucose transporter; member of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose; HXT4 has a paralog, HXT7, that arose from the whole genome duplication hexose transport pentose transmembrane transporter activity|mannose transmembrane transporter activity|glucose transmembrane transporter activity|fructose transmembrane transporter activity integral to membrane|plasma membrane
YHR160C YHR160C PEX18 hom Verified 0.685332396505755 0.246567096551045 no 1214 0.257192029492146 854 NA FT PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION Peroxin required for targeting of peroxisomal matrix proteins containing PTS2; interacts with Pex7p; partially redundant with Pex21p protein import into peroxisome matrix protein binding cytosol|peroxisome
YNL143C_p YNL143C YNL143C hom Uncharacterized 0.684848338059474 0.246719814494338 no 1215 0.263522961168862 891 NA Protein of unknown function; expressed at both mRNA and protein levels biological_process molecular_function cellular_component
YKL130C YKL130C SHE2 hom Verified 0.683722098705473 0.247075333128597 no 1216 0.215365447762188 737 NA FT RNA LOCALIZATION NUCLEUS|SITE OF POLARIZED GROWTH RNA-binding protein that binds specific mRNAs and interacts with She3p; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud mating type switching|intracellular mRNA localization mRNA binding cellular bud tip|cytoplasm
YJR037W_d YJR037W YJR037W hom Dubious 0.683697533925589 0.247083090516099 no 1217 0.226753124150544 726 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene HUL4/YJR036C; deletion mutant has decreased spore survival in Drosophila feces Unknown Unknown Unknown
YPR066W YPR066W UBA3 hom Verified 0.683580449144243 0.247120066870214 no 1218 0.256815005288755 897 NA Protein that acts together with Ula1p to activate Rub1p before its conjugation to proteins (neddylation), which may play a role in protein degradation; GFP-fusion protein localizes to the cytoplasm in a punctate pattern protein neddylation NEDD8 activating enzyme activity cytoplasm
YOL012C YOL012C HTZ1 hom Verified 0.680314375925312 0.2481527119046 no 1219 0.270565675925521 947 NA FF|FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS|CHROMOSOME Histone variant H2AZ, exchanged for histone H2A in nucleosomes by the SWR1 complex; involved in transcriptional regulation through prevention of the spread of silent heterochromatin nuclear-transcribed mRNA catabolic process, non-stop decay|regulation of transcription from RNA polymerase II promoter|chromatin silencing at silent mating-type cassette chromatin binding nuclear chromatin|chromatin assembly complex
YGL215W YGL215W CLG1 hom Verified 0.680211232293413 0.248185360610733 no 1220 0.265103856190496 895 NA FT CELL CYCLE|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS Cyclin-like protein that interacts with Pho85p; has sequence similarity to G1 cyclins PCL1 and PCL2 positive regulation of macroautophagy cyclin-dependent protein kinase regulator activity cyclin-dependent protein kinase holoenzyme complex
YJL045W YJL045W YJL045W hom Verified 0.678484086767363 0.248732405092401 no 1221 0.239853070875903 828 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION Minor succinate dehydrogenase isozyme; homologous to Sdh1p, the major isozyme reponsible for the oxidation of succinate and transfer of electrons to ubiquinone; induced during the diauxic shift in a Cat8p-dependent manner cellular respiration succinate dehydrogenase (ubiquinone) activity mitochondrion
YOL072W YOL072W THP1 hom Verified 0.678280119794439 0.248797050586771 no 1222 0.30497115131858 1048 NA FF|FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|RNA PROCESSING|RESPONSE TO DNA DAMAGE|CELL DIVISION|RNA LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS NUCLEAR PORE Nuclear pore-associated protein; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; contains a PAM domain implicated in protein-protein binding mRNA export from nucleus|mRNA 3'-end processing|transcription-coupled nucleotide-excision repair|cellular bud site selection|nuclear retention of pre-mRNA at the site of transcription|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|transcription elongation from RNA polymerase II promoter double-stranded DNA binding|RNA binding nuclear envelope|nucleus|transcription export complex 2|nuclear pore
YDL100C YDL100C GET3 hom Verified 0.678205067118387 0.248820840107382 no 1223 0.307888241016147 1040 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING|NUCLEOTIDE METABOLISM ENDOPLASMIC RETICULUM|GOLGI APPARATUS Guanine nucleotide exchange factor for Gpa1p; amplifies G protein signaling; subunit of the GET complex, which is involved in Golgi to ER trafficking and insertion of proteins into the ER membrane; has low-level ATPase activity; protein abundance increases in response to DNA replication stress retrograde vesicle-mediated transport, Golgi to ER|pheromone-dependent signal transduction involved in conjugation with cellular fusion|response to heat|protein insertion into ER membrane|response to metal ion|posttranslational protein targeting to membrane ATPase activity|guanyl-nucleotide exchange factor activity endoplasmic reticulum|GET complex
YPR170C_d YPR170C YPR170C hom Dubious 0.677597438813254 0.249013485231049 no 1224 0.306773189727613 1006 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORFs YPR169W-A and YPR170W-B Unknown Unknown Unknown
YOR123C YOR123C LEO1 hom Verified 0.677022635391962 0.249195796432052 no 1225 0.254561351994974 880 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE NUCLEUS RNA POL II, HOLOENZYME Component of the Paf1 complex; which associates with RNA polymerase II and is involved in histone methylation; plays a role in regulating Ty1 transposition; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay chromatin organization|Unknown|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription-coupled nucleotide-excision repair|histone H3-K4 trimethylation|transcription elongation from RNA polymerase II promoter RNA binding|RNA polymerase II transcription factor binding transcription factor activity nucleus|Cdc73/Paf1 complex
YPR159W YPR159W KRE6 hom Verified 0.677005043160624 0.249201377303853 no 1226 0.280658228717223 951 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE Type II integral membrane protein required for beta-1,6 glucan biosynthesis; putative beta-glucan synthase; localizes to the ER, plasma membrane, sites of polarized growth and secretory vesicles; functionally redundant with Skn1p fungal-type cell wall organization|(1->6)-beta-D-glucan biosynthetic process glucosidase activity integral to endoplasmic reticulum membrane|integral to membrane|site of polarized growth|transport vesicle|plasma membrane
YHR064C YHR064C SSZ1 hom Verified 0.676937257559174 0.249222881891728 no 1227 0.213070604258345 774 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION Hsp70 protein that interacts with Zuo1p (a DnaJ homolog) to form a ribosome-associated complex that binds the ribosome via the Zuo1p subunit; also involved in pleiotropic drug resistance via sequential activation of PDR1 and PDR5; binds ATP cytoplasmic translation|regulation of translational fidelity|rRNA processing unfolded protein binding polysome|cytoplasm
YBR255W YBR255W MTC4 hom Verified 0.676595635986486 0.249331274366344 no 1228 0.27237051546401 917 NA Protein of unknown function, required for normal growth rate at 15 degrees C; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; mtc4 is synthetically sick with cdc13-1 biological_process molecular_function cytoplasm
YBR271W YBR271W EFM2 hom Verified 0.675803499015385 0.249582706434226 no 1229 0.282554713395972 950 NA S-adenosylmethionine-dependent methyltransferase; methylates translation elongation factors EF2 (Eft1p and Eft2p) and EF3A (Yef3p); belongs to the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; predicted to be involved in ribosome biogenesis peptidyl-lysine methylation S-adenosylmethionine-dependent methyltransferase activity|protein-lysine N-methyltransferase activity cytoplasm
YBL072C YBL072C RPS8A hom Verified 0.675286419962423 0.249746905044686 no 1230 0.233394533596997 840 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S8, no bacterial homolog; RPS8A has a paralog, RPS8B, that arose from the whole genome duplication cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) structural constituent of ribosome cytosolic small ribosomal subunit|90S preribosome
YIL090W YIL090W ICE2 hom Verified 0.67348417371852 0.250319656984333 no 1231 0.260582577869265 912 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Integral ER membrane protein with type-III transmembrane domains; required for maintenance of ER zinc homeostasis; necessary for efficient targeting of Trm1p tRNA methyltransferase to inner nuclear membrane; mutations cause defects in cortical ER morphology in both the mother and daughter cells endoplasmic reticulum inheritance molecular_function integral to endoplasmic reticulum membrane|integral to membrane|endoplasmic reticulum
YOR293W YOR293W RPS10A hom Verified 0.672741065003229 0.250556018743318 no 1232 0.213799705195052 686 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10A has a paralog, RPS10B, that arose from the whole genome duplication cytoplasmic translation|rRNA export from nucleus structural constituent of ribosome cytosolic small ribosomal subunit
YBL010C_p YBL010C YBL010C hom Uncharacterized 0.67237568853539 0.250672277959399 no 1233 0.24789439392127 874 NA FT NUCLEUS Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein colocalizes with clathrin-coated vesicles biological_process molecular_function clathrin-coated vesicle
YOR137C YOR137C SIA1 hom Verified 0.67165732168488 0.250900938542882 no 1234 0.229211532186125 807 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS Protein of unassigned function involved in activation of the Pma1p plasma membrane H+-ATPase by glucose proton transport molecular_function cellular_component
YKR077W YKR077W MSA2 hom Verified 0.670705201105784 0.251204174424156 no 1235 0.249342815452793 867 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE NUCLEUS Putative transcriptional activator, that interacts with G1-specific transcription factor, MBF and G1-specific promoters; ortholog of Msa2p, an MBF and SBF activator that regulates G1-specific transcription and cell cycle initiation regulation of transcription involved in G1 phase of mitotic cell cycle molecular_function nucleus|cytoplasm
YOR141C YOR141C ARP8 hom Verified 0.6697546362718 0.25150710805582 no 1236 0.253824237696299 917 NA FT CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME|CYTOSKELETON Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes; has mRNA binding activity mitotic recombination|response to DNA damage stimulus|chromatin remodeling mRNA binding|ATP-dependent 3'-5' DNA helicase activity nucleus|Ino80 complex
YKL018C-A_p YKL018C-A YKL018C-A hom Uncharacterized 0.668564216278925 0.251886752721271 no 1237 0.225620786474424 790 NA Putative protein of unknown function; identified by homology; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm biological_process molecular_function cytoplasm
YDL036C YDL036C PUS9 hom Verified 0.668491211553853 0.251910044978104 no 1238 0.232651459493604 756 NA FT RNA PROCESSING NUCLEUS|MITOCHONDRION Mitochondrial tRNA:pseudouridine synthase, catalyzes the formation of pseudouridine at position 32 in mitochondrial tRNAs; contains an N-terminal mitochondrial targeting sequence tRNA pseudouridine synthesis pseudouridine synthase activity mitochondrion|nucleus|cytoplasm
YDL198C YDL198C GGC1 hom Verified 0.667936892834765 0.252086938198595 no 1239 0.260382144746376 881 NA FT ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS MITOCHONDRION Mitochondrial GTP/GDP transporter, essential for mitochondrial genome maintenance; has a role in mitochondrial iron transport; member of the mitochondrial carrier family cellular iron ion homeostasis|mitochondrial genome maintenance|transmembrane transport|guanine nucleotide transport guanine nucleotide transmembrane transporter activity mitochondrion|integral to membrane|mitochondrial inner membrane
YDR063W YDR063W AIM7 hom Verified 0.667907788458555 0.252096227746513 no 1240 0.234780845978997 813 NA FT CYTOSKELETON ORGANIZATION NUCLEUS|CYTOSKELETON Protein that interacts with Arp2/3 complex to stimulate actin filament debranching and inhibit actin nucleation; has similarity to Cof1p and also to human glia maturation factor (GMF); null mutant displays elevated mitochondrial genome loss actin filament debranching|negative regulation of Arp2/3 complex-mediated actin nucleation molecular_function nucleus|actin cortical patch|cytoplasm
YDR519W YDR519W FPR2 hom Verified 0.667674348126445 0.252170743869473 no 1241 0.278490471729897 958 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Membrane-bound peptidyl-prolyl cis-trans isomerase (PPIase); binds to the drugs FK506 and rapamycin; expression pattern suggests possible involvement in ER protein trafficking; relocalizes from nucleus to vacuole upon DNA replication stress biological_process FK506 binding|peptidyl-prolyl cis-trans isomerase activity endoplasmic reticulum membrane
YCR050C_p YCR050C YCR050C hom Uncharacterized 0.667578848880156 0.2522012313823 no 1242 0.217813452583501 745 NA Non-essential protein of unknown function; deletion mutant is synthetically sick or lethal with alpha-synuclein biological_process molecular_function cellular_component
YMR082C_d YMR082C YMR082C hom Dubious 0.666531135046697 0.252535834808495 no 1243 0.270309694082472 897 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YPR101W YPR101W SNT309 hom Verified 0.664978992626323 0.253031964799304 no 1244 0.267958809229694 953 NA FT RNA PROCESSING NUCLEUS Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; interacts physically and genetically with Prp19p mRNA splicing, via spliceosome first spliceosomal transesterification activity Prp19 complex|U2-type catalytic step 1 spliceosome
YCL034W YCL034W LSB5 hom Verified 0.663118488481654 0.253627335237338 no 1245 0.273311431974301 918 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION CYTOSKELETON Protein of unknown function; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; may mediate disassembly of the Pan1 complex from the endocytic coat endocytosis|actin filament organization|actin cortical patch localization|actin cytoskeleton organization molecular_function cell cortex|cytoplasm|actin cortical patch
YJR120W YJR120W YJR120W hom Verified 0.662973661389271 0.253673711464492 no 1246 0.251597538093958 875 NA FT OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p cellular respiration|sterol transport|mitochondrion organization molecular_function cellular_component
YDL187C_d YDL187C YDL187C hom Dubious 0.661932754748726 0.254007159386459 no 1247 0.275600852480109 926 NA Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YNL043C_d YNL043C YNL043C hom Dubious 0.660310366282121 0.254527339566009 no 1248 0.259072865273843 894 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YIP3/YNL044W Unknown Unknown Unknown
YHR094C YHR094C HXT1 hom Verified 0.65973611061695 0.254711594595583 no 1249 0.250143781656931 859 NA FT PLASMA MEMBRANE Low-affinity glucose transporter of the major facilitator superfamily, expression is induced by Hxk2p in the presence of glucose and repressed by Rgt1p when glucose is limiting; HXT1 has a paralog, HXT6, what arose from the whole genome duplication mannose transport|glucose transport galactose transmembrane transporter activity|pentose transmembrane transporter activity|mannose transmembrane transporter activity|glucose transmembrane transporter activity|fructose transmembrane transporter activity integral to membrane|plasma membrane
YMR138W YMR138W CIN4 hom Verified 0.65933973639068 0.254838815516204 no 1250 0.264584137263741 918 NA FT SIGNALING GTP-binding protein involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl; regulated by the GTPase-activating protein, Cin2p, the human retinitis pigmentosa 2 (RP2) homolog protein folding|tubulin complex assembly|tubulin complex biogenesis GTP binding cytoplasm
YKL136W_d YKL136W YKL136W hom Dubious 0.659135241722744 0.254904463463561 no 1251 0.280066460365364 942 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF APL2/YKL135C Unknown Unknown Unknown
YJL096W YJL096W MRPL49 hom Verified 0.65912051891133 0.254909190198958 no 1252 0.276796822004425 941 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YDL065C YDL065C PEX19 hom Verified 0.65847245605449 0.255117295195598 no 1253 0.256536003835564 877 NA FT PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Chaperone and import receptor for newly-synthesized class I PMPs; binds peroxisomal membrane proteins (PMPs) in the cytoplasm and delivers them to the peroxisome for subsequent insertion into the peroxisomal membrane; interacts with Myo2p and contributes to peroxisome partitioning protein stabilization|protein import into peroxisome membrane|peroxisome inheritance|ER-dependent peroxisome organization|protein exit from endoplasmic reticulum peroxisome membrane targeting sequence binding|protein binding cytosol|peroxisomal membrane|endoplasmic reticulum
YFR023W YFR023W PES4 hom Verified 0.658382843749839 0.25514607835925 no 1254 0.265563562460499 885 NA FT NUCLEUS Poly(A) binding protein, suppressor of DNA polymerase epsilon mutation; PES4 has a paralog, MIP6, that arose from the whole genome duplication biological_process molecular_function cellular_component
YHR022C_p YHR022C YHR022C hom Uncharacterized 0.658298305937991 0.255173233169998 no 1255 0.242380041740997 849 NA FT SIGNALING Putative protein of unknown function; YHR022C is not an essential gene biological_process molecular_function cellular_component
YDR264C YDR264C AKR1 hom Verified 0.657302689521697 0.255493153742854 no 1256 0.384195816371809 1285 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Palmitoyl transferase involved in protein palmitoylation; acts as a negative regulator of pheromone response pathway; required for endocytosis of pheromone receptors; involved in cell shape control; contains ankyrin repeats; AKR1 has a paralog, AKR2, that arose from the whole genome duplication protein targeting to membrane|regulation of endocytosis|regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion|protein palmitoylation palmitoyltransferase activity integral to membrane|Golgi apparatus|membrane
YDR273W YDR273W DON1 hom Verified 0.657123995740507 0.255550595435849 no 1257 0.225999351982089 802 NA FT CELL CYCLE|CELL WALL ORG/BIOGENESIS|CELL DIVISION Meiosis-specific component of the spindle pole body, part of the leading edge protein (LEP) coat, forms a ring-like structure at the leading edge of the prospore membrane during meiosis II meiosis|ascospore wall assembly molecular_function prospore membrane
YOR111W_p YOR111W YOR111W hom Uncharacterized 0.656880278683902 0.2556289499443 no 1258 0.237784331687636 837 NA Putative protein of unknown function biological_process molecular_function cellular_component
YKR030W YKR030W GMH1 hom Verified 0.656205069329121 0.255846093810687 no 1259 0.237282898792392 825 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS Golgi membrane protein of unknown function, interacts with Gea1p and Gea2p; required for localization of Gea2p; computational analysis suggests a possible role in either cell wall synthesis or protein-vacuolar targeting transport molecular_function integral to membrane|integral to Golgi membrane
YNL099C YNL099C OCA1 hom Verified 0.65492441830579 0.256258208919541 no 1260 0.273147995296744 941 NA FF|FT RESPONSE TO OXIDATIVE STRESS Putative protein tyrosine phosphatase, required for cell cycle arrest in response to oxidative damage of DNA cellular response to oxidative stress protein tyrosine phosphatase activity cytoplasm
YPL249C YPL249C GYP5 hom Verified 0.654905156306768 0.256264410095655 no 1261 0.240211256563807 808 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING|NUCLEOTIDE METABOLISM GOLGI APPARATUS|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE GTPase-activating protein (GAP) for yeast Rab family members; involved in ER to Golgi trafficking; exhibits GAP activity toward Ypt1p that is stimulated by Gyl1p, also acts on Sec4p; interacts with Gyl1p, Rvs161p and Rvs167p; involved in recruiting Rvs167p to the bud tip during polarized growth; relocalizes from bud neck to cytoplasm upon DNA replication stress vesicle-mediated transport|ER to Golgi vesicle-mediated transport Rab GTPase activator activity cytosol|incipient cellular bud site|plasma membrane|cellular bud neck|Golgi-associated vesicle|cellular bud tip
YER154W YER154W OXA1 hom Verified 0.65346049836135 0.256729723742621 no 1262 0.273498964550811 960 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial inner membrane insertase, mediates the insertion of both mitochondrial- and nuclear-encoded proteins from the matrix into the inner membrane, interacts with mitochondrial ribosomes; conserved from bacteria to animals protein insertion into mitochondrial membrane from inner side|mitochondrial genome maintenance|mitochondrial proton-transporting ATP synthase complex assembly mitochondrial ribosome binding|membrane insertase activity mitochondrion|mitochondrial inner boundary membrane|integral to membrane|mitochondrial crista|mitochondrial large ribosomal subunit
YGR049W YGR049W SCM4 hom Verified 0.653312046240913 0.256777563983312 no 1263 0.265176003924103 880 NA FT MITOCHONDRION Mitochondrial outer membrane protein of unknown function; predicted to have 4 transmembrane segments; import is mediated by Tom70p and Mim1p; interacts genetically with a cdc4 mutation biological_process molecular_function mitochondrial outer membrane|mitochondrion|integral to membrane
YKL102C_d YKL102C YKL102C hom Dubious 0.652751230491891 0.256958334564019 no 1264 0.245008470423618 823 NA Dubious open reading frame unlikely to encode a functional protein; deletion confers sensitivity to citric acid; predicted protein would include a thiol-disulfide oxidoreductase active site Unknown Unknown Unknown
YMR029C YMR029C FAR8 hom Verified 0.652400306920943 0.257071483203736 no 1265 0.235881720843576 781 NA FT CELL CYCLE|SIGNALING ENDOPLASMIC RETICULUM Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far9p, Far10p, and Far11p re-entry into mitotic cell cycle after pheromone arrest molecular_function cellular_component
YFR054C_d YFR054C YFR054C hom Dubious 0.652080004598856 0.257174781218756 no 1266 0.229610021896251 792 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YDL216C YDL216C RRI1 hom Verified 0.651741468988507 0.257283982953262 no 1267 0.262057832777256 931 NA FT SIGNALING|PROTEOLYSIS NUCLEUS Catalytic subunit of the COP9 signalosome (CSN) complex that acts as an isopeptidase in cleaving the ubiquitin-like protein Nedd8 from SCF ubiquitin ligases; metalloendopeptidase involved in the adaptation to pheromone signaling adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion|cullin deneddylation metalloendopeptidase activity signalosome
YHR115C YHR115C DMA1 hom Verified 0.650247036781157 0.257766331159977 no 1268 0.266235740655527 925 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION Ubiquitin-protein ligase (E3); controls septin dynamics and the spindle position checkpoint (SPOC) along with functionally redundant ligase Dma2p by regulating the recruitment of Elm1p to the bud neck; regulates levels of the translation initiation factor eIF2 subunit Gcd11p, as well as abundance, localization, and ubiquitination of Cdk inhibitory kinase Swe1p; ubiquitinates cyclin Pcl1p; ortholog of human RNF8 protein, similar to human Chfr; contains FHA and RING finger establishment of mitotic spindle orientation|protein autoubiquitination|septin ring assembly|mitotic cell cycle spindle assembly checkpoint ubiquitin-protein ligase activity cytoplasm
YDR450W YDR450W RPS18A hom Verified 0.650162632573805 0.257793587756161 no 1269 0.269764667644671 929 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION MITOCHONDRION RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S18 and bacterial S13; RPS18A has a paralog, RPS18B, that arose from the whole genome duplication; protein increases in abundance and relocalizes from cytoplasm to nuclear foci upon DNA replication stress endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|cytoplasmic translation|rRNA export from nucleus structural constituent of ribosome cytosolic small ribosomal subunit|mitochondrion
YJR014W YJR014W TMA22 hom Verified 0.646859003186243 0.258861600573134 no 1270 0.201607031115112 665 NA FT TRANSLATION RIBOSOME Protein of unknown function; associates with ribosomes and has a putative RNA binding domain; interacts with Tma20p; similar to human GRAP and human DRP1, which interacts with human Tma20p homolog MCT-1; protein abundance increases in response to DNA replication stress biological_process RNA binding ribosome|cytoplasm
YJR010C-A YJR010C-A SPC1 hom Verified 0.646780530850341 0.258886997285086 no 1271 0.262127710833125 918 NA FT PROTEIN LOCALIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Subunit of the signal peptidase complex (SPC); SPC cleaves the signal sequence from proteins targeted to the endoplasmic reticulum (ER); homolog of the SPC12 subunit of mammalian signal peptidase complex; protein abundance increases in response to DNA replication stress signal peptide processing|protein targeting to ER molecular_function signal peptidase complex
YJL112W YJL112W MDV1 hom Verified 0.646110569994205 0.259103875249219 no 1272 0.277820746979493 977 NA FT MITOCHONDRION ORGANIZATION|PEROXISOME ORGANIZATION MITOCHONDRION Peripheral protein of cytosolic face of mitochondrial outer membrane; required for mitochondrial fission; interacts with Fis1p and with the dynamin-related GTPase Dnm1p; contains WD repeats; MDV1 has a paralog, CAF4, that arose from the whole genome duplication peroxisome fission|mitochondrial fission|mitochondrial genome maintenance ubiquitin binding mitochondrial outer membrane|mitochondrion
YGR003W YGR003W CUL3 hom Verified 0.645761045951367 0.25921705952858 no 1273 0.24407990942734 790 NA FT PROTEOLYSIS NUCLEUS UBIQUITIN LIGASE COMPLEX Ubiquitin-protein ligase, forms a complex with Elc1p that polyubiquitylates monoubiquitylated RNA polymerase II to trigger its proteolysis; cullin family member with similarity to Cdc53p and human CUL3 protein ubiquitination involved in ubiquitin-dependent protein catabolic process|ubiquitin-dependent protein catabolic process ubiquitin-protein ligase activity nucleus|Cul3-RING ubiquitin ligase complex|cytoplasm
YKL076C_d YKL076C PSY1 hom Dubious 0.645568282978882 0.259279491739868 no 1274 0.264841047823316 934 NA Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 69% of ORF overlaps the uncharacterized ORF YKL075C Unknown Unknown Unknown
YMR304W YMR304W UBP15 hom Verified 0.64370050765858 0.259884830335314 no 1275 0.291292139565881 973 NA FT PROTEOLYSIS Ubiquitin-specific protease involved in protein deubiquitination; catalytic activity regulated by an N-terminal TRAF-like domain and and C-terminal sequences; physically interacts with anaphase-promoting complex/cyclosome (APC/C) activator, Cdh1p; forms a complex with AAA peroxins Pex1p and Pex6p protein deubiquitination ubiquitin-specific protease activity peroxisome|cytoplasm
YOR007C YOR007C SGT2 hom Verified 0.643223141040309 0.260039659862795 no 1276 0.244039166346156 818 NA FT PROTEIN LOCALIZATION Glutamine-rich cytoplasmic cochaperone; serves as a scaffold bringing together Get4, Get5p, and other TRC complex members that are required to mediate posttranslational insertion of tail-anchored proteins into the ER membrane; interacts with the prion domain of Sup35p; amyloid sensor; plays a role in targeting chaperones to prion aggregates; has similarity to human cochaperone SGT; forms cytoplasmic foci upon DNA replication stress response to heat|posttranslational protein targeting to membrane molecular_function TRC complex|cytoplasm
YMR035W YMR035W IMP2 hom Verified 0.64175881582509 0.260514896991144 no 1277 0.229063387415475 780 NA FT PROTEIN LOCALIZATION|PROTEOLYSIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p protein processing involved in protein targeting to mitochondrion endopeptidase activity mitochondrial inner membrane peptidase complex
YLR171W_d YLR171W YLR171W hom Dubious 0.640587110655325 0.260895488036 no 1278 0.272465083764133 955 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YGR110W YGR110W CLD1 hom Verified 0.638249185375011 0.261655742144644 no 1279 0.275538063132702 936 NA FT LIPID METABOLISM MITOCHONDRION Mitochondrial cardiolipin-specific phospholipase; functions upstream of Taz1p to generate monolyso-cardiolipin; transcription increases upon genotoxic stress; involved in restricting Ty1 transposition; has homology to mammalian CGI-58 cardiolipin acyl-chain remodeling|cardiolipin metabolic process phospholipase A2 activity mitochondrion
YAL005C YAL005C SSA1 hom Verified 0.637926004581544 0.261760924490747 no 1280 0.22562312620984 778 NA FT PROTEIN LOCALIZATION|TRANSLATION|MITOCHONDRION ORGANIZATION NUCLEUS ATPase involved in protein folding and NLS-directed nuclear transport; member of HSP70 family; forms chaperone complex with Ydj1p; localized to nucleus, cytoplasm, and cell wall; 98% identical with paralog Ssa2p, but subtle differences between the two proteins provide functional specificity with respect to propagation of yeast [URE3] prions and vacuolar-mediated degradations of gluconeogenesis enzymes; general targeting factor of Hsp104p to prion fibrils cytoplasmic translation|protein folding|protein refolding|protein targeting to mitochondrion|SRP-dependent cotranslational protein targeting to membrane, translocation|protein import into nucleus, translocation|response to stress unfolded protein binding|ATPase activity fungal-type vacuole membrane|fungal-type cell wall|plasma membrane|nucleus|polysome|chaperonin-containing T-complex|cytoplasm
YMR063W YMR063W RIM9 hom Verified 0.637085427333173 0.262034600110801 no 1281 0.303323608847779 1073 NA FF|FT ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE Plasma membrane protein of unknown function; involved in the proteolytic activation of Rim101p in response to alkaline pH; interacts with Rim21p and Dfg16p to form a pH-sensing complex in the Rim101 pathway and is required to maintain Rim21p levels; has similarity to A. nidulans PalI; ascospore formation molecular_function integral to membrane
YMR305C YMR305C SCW10 hom Verified 0.636342401431094 0.262276636977025 no 1282 0.264626238474189 878 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM ENDOPLASMIC RETICULUM Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on mutant phenotype and its regulation by Ste12p conjugation with cellular fusion glucosidase activity fungal-type cell wall|extracellular region|endoplasmic reticulum|cytoplasm
YBL005W YBL005W PDR3 hom Verified 0.636258509241328 0.262303971619455 no 1283 0.255569998467099 895 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Transcriptional activator of the pleiotropic drug resistance network; regulates expression of ATP-binding cassette (ABC) transporters through binding to cis-acting sites known as PDREs (PDR responsive elements); post-translationally up-regulated in cells lacking a functional mitochondrial genome; PDR3 has a paralog, PDR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress Unknown|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus|cytoplasm
YFR045W_p YFR045W YFR045W hom Uncharacterized 0.634682464332302 0.262817766335673 no 1284 0.238064043545357 839 NA FT MITOCHONDRION Putative mitochondrial transport protein; null mutant is viable, exhibits decreased levels of chitin and normal resistance to calcofluor white transport transporter activity integral to membrane|mitochondrial inner membrane
YER117W YER117W RPL23B hom Verified 0.634557337966615 0.262858579896896 no 1285 0.259594007296488 907 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L23B; homologous to mammalian ribosomal protein L23 and bacterial L14; RPL23B has a paralog, RPL23A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YPR047W YPR047W MSF1 hom Verified 0.633262849920177 0.263281004504133 no 1286 0.294636251756546 1033 NA FT KETONE METABOLISM|RNA PROCESSING|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial phenylalanyl-tRNA synthetase, active as a monomer, unlike the cytoplasmic subunit which is active as a dimer complexed to a beta subunit dimer; similar to the alpha subunit of E. coli phenylalanyl-tRNA synthetase phenylalanyl-tRNA aminoacylation|mitochondrial phenylalanyl-tRNA aminoacylation phenylalanine-tRNA ligase activity mitochondrion
YKL039W YKL039W PTM1 hom Verified 0.631791782921034 0.263761471854072 no 1287 0.252390644955542 854 NA FT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Protein of unknown function; copurifies with late Golgi vesicles containing the v-SNARE Tlg2p; PTM1 has a paralog, YHL017W, that arose from the whole genome duplication biological_process molecular_function integral to membrane
YLL030C_d YLL030C RRT7 hom Dubious 0.630770101562527 0.264095427626551 no 1288 0.248961205976609 857 NA Identified in a screen for mutants with increased levels of rDNA transcription; dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YPL270W YPL270W MDL2 hom Verified 0.629944056346449 0.264365593452108 no 1289 0.272121192248243 941 NA FT NUCLEOTIDE METABOLISM MITOCHONDRION Mitochondrial inner membrane half-type ATP-binding cassette (ABC) transporter, required for respiratory growth at high temperature; similar to human TAP1 and TAP2 implicated in bare lymphocyte syndrome and Wegener-like granulomatosis oligopeptide transport|oligopeptide export from mitochondrion oligopeptide-transporting ATPase activity mitochondrion|integral to membrane|mitochondrial inner membrane
YLR385C YLR385C SWC7 hom Verified 0.62874760514171 0.264757153337732 no 1290 0.256692871248508 881 NA FT CHROMATIN ORGANIZATION NUCLEUS|CHROMOSOME Protein of unknown function, component of the Swr1p complex that incorporates Htz1p into chromatin chromatin remodeling molecular_function Swr1 complex|nucleus
YKL096W-A YKL096W-A CWP2 hom Verified 0.625956307045451 0.265671800216191 no 1291 0.266983914584691 923 NA FT ION HOMEOSTASIS|CELL WALL ORG/BIOGENESIS|ION HOMEOSTASIS Covalently linked cell wall mannoprotein, major constituent of the cell wall; plays a role in stabilizing the cell wall; involved in low pH resistance; precursor is GPI-anchored fungal-type cell wall organization|regulation of pH structural constituent of cell wall fungal-type cell wall
YHR161C YHR161C YAP1801 hom Verified 0.625599091351846 0.265788967463967 no 1292 0.267504783048034 924 NA FT VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON Protein of the AP180 family, involved in clathrin cage assembly; binds Pan1p and clathrin; YAP1801 has a paralog, YAP1802, that arose from the whole genome duplication endocytosis clathrin binding actin cortical patch
YFL063W_d YFL063W YFL063W hom Dubious 0.622560964946099 0.266786534730616 no 1293 0.224063301838393 763 NA Dubious open reading frame, based on available experimental and comparative sequence data Unknown Unknown Unknown
YDR174W YDR174W HMO1 hom Verified 0.62073158683748 0.267388121446931 no 1294 0.265337759523851 954 NA FT TRANSCRIPTION FROM RNA POL II|RIBOSOME BIOGENESIS|CHROMATIN ORGANIZATION NUCLEUS|CHROMOSOME Chromatin associated high mobility group (HMG) family member involved in genome maintenance; rDNA-binding component of the Pol I transcription system; associates with a 5'-3' DNA helicase and Fpr1p, a prolyl isomerase regulation of transcription from RNA polymerase I promoter|regulation of transcription by chromatin organization|regulation of ribosomal protein gene transcription from RNA polymerase II promoter double-stranded DNA binding|four-way junction DNA binding|DNA binding, bending nuclear chromatin|nucleolus|cytoplasm
YOR021C YOR021C SFM1 hom Verified 0.620626463897564 0.267422711659275 no 1295 0.253260304215605 853 NA SPOUT methyltransferase; catalyzes omega-monomethylation of Rps3p on Arg-146; not an essential gene; predicted to be involved in rRNA processing and ribosome biogenesis and in biopolymer catabolism peptidyl-arginine methylation protein-arginine omega-N monomethyltransferase activity cellular_component
YBR210W YBR210W ERV15 hom Verified 0.619721880496283 0.267720453841442 no 1296 0.24849085292901 823 NA FT VESICLE-MEDIATED TRANSPORT|CELL CYCLE|SIGNALING|CELL DIVISION Protein involved in export of proteins from the endoplasmic reticulum; ERV15 has a paralog, ERV14, that arose from the whole genome duplication ER to Golgi vesicle-mediated transport|axial cellular bud site selection molecular_function integral to membrane|ER to Golgi transport vesicle
YML014W YML014W TRM9 hom Verified 0.61932308616 0.267851769396662 no 1297 0.2400547537614 832 NA FT RNA PROCESSING NUCLEUS tRNA methyltransferase; catalyzes modification of wobble bases in tRNA anticodons to 2, 5-methoxycarbonylmethyluridine and 5-methoxycarbonylmethyl-2-thiouridine; may act as part of a complex with Trm112p; deletion mutation increases translational infidelity, including amino acid misincorporation and -1 frameshifting, and also confers resistance to zymocin; null mutant displays activation of stress responses chronological cell aging|tRNA methylation|tRNA wobble uridine modification|response to stress tRNA (uracil) methyltransferase activity nucleus|cytoplasm
YMR189W YMR189W GCV2 hom Verified 0.619192862875592 0.267894656527324 no 1298 0.237916324862944 805 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS MITOCHONDRION P subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of 5,10-methylene-THF in the cytoplasm glycine decarboxylation via glycine cleavage system|one-carbon metabolic process glycine dehydrogenase (decarboxylating) activity mitochondrion|glycine cleavage complex
YBR001C YBR001C NTH2 hom Verified 0.619105899592655 0.267923298536225 no 1299 0.324097151859622 1126 NA FF|FT CARBOHYDRATE METABOLISM MITOCHONDRION Putative neutral trehalase, required for thermotolerance; may mediate resistance to other cellular stresses; NTH2 has a paralog, NTH1, that arose from the whole genome duplication trehalose catabolic process alpha,alpha-trehalase activity mitochondrion|cytoplasm
YNL230C YNL230C ELA1 hom Verified 0.617328220272733 0.268509128309836 no 1300 0.278750453277884 975 NA FT PROTEOLYSIS NUCLEUS UBIQUITIN LIGASE COMPLEX Elongin A; F-box protein that forms a heterodimer with Elc1p and is required for ubiquitin-dependent degradation of the RNA Polymerase II subunit Rpo21p; subunit of the Elongin-Cullin-Socs (ECS) ligase complex protein ubiquitination involved in ubiquitin-dependent protein catabolic process ubiquitin-protein ligase activity elongin complex|Cul3-RING ubiquitin ligase complex
YBR249C YBR249C ARO4 hom Verified 0.616964614891518 0.26862903283171 no 1301 0.265053247950546 921 NA FT KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase; catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by tyrosine or high concentrations of phenylalanine or tryptophan; relative distribution to the nucleus increases upon DNA replication stress aromatic amino acid family biosynthetic process 3-deoxy-7-phosphoheptulonate synthase activity nucleus|cytoplasm
YBR081C YBR081C SPT7 hom Verified 0.616748594306509 0.268700281714179 no 1302 0.32522715984137 1102 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CHROMATIN ORGANIZATION NUCLEUS|MITOCHONDRION HISTONE ACETYLTRANSFERASE Subunit of the SAGA transcriptional regulatory complex, involved in proper assembly of the complex; also present as a C-terminally truncated form in the SLIK/SALSA transcriptional regulatory complex conjugation with cellular fusion|histone acetylation|protein complex assembly|chromatin modification structural molecule activity SLIK (SAGA-like) complex|mitochondrion|SAGA complex
YDL130W-A YDL130W-A STF1 hom Verified 0.613548734246869 0.269756784652773 no 1303 0.284915964471311 1002 NA FT NUCLEOTIDE METABOLISM MITOCHONDRION Protein involved in regulation of the mitochondrial F1F0-ATP synthase; Stf1p and Stf2p act as stabilizing factors that enhance inhibitory action of the Inh1p protein; protein abundance increases in response to DNA replication stress negative regulation of ATPase activity molecular_function mitochondrion|mitochondrial proton-transporting ATP synthase complex
YNL133C YNL133C FYV6 hom Verified 0.613358403839633 0.269819691836916 no 1304 0.303507500114357 1048 NA FT RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME Protein of unknown function, required for survival upon exposure to K1 killer toxin; proposed to regulate double-strand break repair via non-homologous end-joining double-strand break repair via nonhomologous end joining molecular_function nucleus
YBR251W YBR251W MRPS5 hom Verified 0.611588982592667 0.270404864623803 no 1305 0.31021099383369 1046 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the small subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial small ribosomal subunit
YPL220W YPL220W RPL1A hom Verified 0.611358658246487 0.270481082792239 no 1306 0.255143116392061 891 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L1A; N-terminally acetylated; homologous to mammalian ribosomal protein L10A and bacterial L1; RPL1A has a paralog, RPL1B, that arose from the whole genome duplication; rpl1a rpl1b double null mutation is lethal cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YDL081C YDL081C RPP1A hom Verified 0.611238215445543 0.270520943598274 no 1307 0.266123107981779 890 NA FT TRANSLATION RIBOSOME Ribosomal stalk protein P1 alpha, involved in the interaction between translational elongation factors and the ribosome; accumulation of P1 in the cytoplasm is regulated by phosphorylation and interaction with the P2 stalk component cytoplasmic translation|translational elongation structural constituent of ribosome cytosolic large ribosomal subunit
YGR229C YGR229C SMI1 hom Verified 0.609704947961735 0.271028638143018 no 1308 0.310147355206264 1058 NA FF|FT CELL CYCLE|CELL WALL ORG/BIOGENESIS NUCLEUS|SITE OF POLARIZED GROWTH Protein involved in the regulation of cell wall synthesis; proposed to be involved in coordinating cell cycle progression with cell wall integrity regulation of mitotic cell cycle|regulation of fungal-type cell wall biogenesis molecular_function incipient cellular bud site|cellular bud neck|mating projection tip
YLR296W_d YLR296W YLR296W hom Dubious 0.608738955728901 0.271348740734462 no 1309 0.271427002737706 928 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YGR262C YGR262C BUD32 hom Verified 0.608323267951858 0.271486545900564 no 1310 0.318019850473101 1054 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|LIPID METABOLISM|CELL DIVISION|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION NUCLEUS|CHROMOSOME Protein kinase, component of the EKC/KEOPS complex with Kae1p, Cgi121p, Pcc1p, and Gon7p; EKC/KEOPS complex is required for t6A tRNA modification and may have roles in telomere maintenance and transcription threonylcarbamoyladenosine metabolic process|protein phosphorylation|telomere maintenance|cellular bud site selection|positive regulation of transcription from RNA polymerase II promoter protein serine/threonine kinase activity EKC/KEOPS complex|nucleus|cytoplasm
YNL166C YNL166C BNI5 hom Verified 0.608044419993469 0.271579006661831 no 1311 0.244092041944122 808 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH|CYTOSKELETON Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner septin ring assembly|cytokinesis molecular_function cellular bud neck septin ring|cellular bud neck
YBR164C YBR164C ARL1 hom Verified 0.608035947592875 0.271581816196653 no 1312 0.326119433534314 1129 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING|VACUOLAR TRANSPORT GOLGI APPARATUS Soluble GTPase with a role in regulation of membrane traffic; regulates potassium influx; G protein of the Ras superfamily, similar to ADP-ribosylation factor Golgi to plasma membrane protein transport|vesicle-mediated transport|protein targeting to vacuole GTPase activity trans-Golgi network|cytosol|Golgi apparatus
YPR054W YPR054W SMK1 hom Verified 0.607635536430918 0.271714613142948 no 1313 0.246385110130655 888 NA FT SIGNALING|CELL WALL ORG/BIOGENESIS|PROTEIN PHOSPHORYLATION MITOCHONDRION Middle sporulation-specific mitogen-activated protein kinase (MAPK) required for production of the outer spore wall layers; negatively regulates activity of the glucan synthase subunit Gsc2p ascospore wall assembly|protein phosphorylation|negative regulation of sporulation resulting in formation of a cellular spore MAP kinase activity mitochondrion
YLR306W YLR306W UBC12 hom Verified 0.607377259424629 0.271800288233957 no 1314 0.256880370836734 879 NA Enzyme that mediates the conjugation of Rub1p, a ubiquitin-like protein, to other proteins; related to E2 ubiquitin-conjugating enzymes protein neddylation NEDD8 ligase activity cellular_component
YLR404W YLR404W FLD1 hom Verified 0.607091717826531 0.271895023120615 no 1315 0.274114076854077 914 NA FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Seipin protein involved in lipid droplet morphology, number, and size; proposed to be involved in lipid metabolism; related to the human BSCL2 which is associated with lipodystrophy lipid particle organization molecular_function integral to membrane|endoplasmic reticulum|cortical endoplasmic reticulum
YPL263C YPL263C KEL3 hom Verified 0.605950567043183 0.272273789641621 no 1316 0.24479822737369 825 NA Cytoplasmic protein of unknown function biological_process molecular_function cytoplasm
YNL194C YNL194C YNL194C hom Verified 0.605895649870275 0.27229202415546 no 1317 0.262241589344835 902 NA FT ENDOPLASMIC RETICULUM|PLASMA MEMBRANE Integral membrane protein required for sporulation and plasma membrane sphingolipid content; has sequence similarity to SUR7 and FMP45; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; GFP-fusion protein is more abundant at MCCs (membrane compartment occupied by Can1) in the presence of glycerol and oleate ascospore formation molecular_function cell cortex|integral to membrane|endoplasmic reticulum|plasma membrane|cytoplasm
YER071C_p YER071C TDA2 hom Uncharacterized 0.605623808451833 0.272382294402497 no 1318 0.264375127304369 872 NA FT SITE OF POLARIZED GROWTH Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; null mutant is sensitive to expression of the top1-T722A allele biological_process molecular_function mating projection tip|cytoplasm
YDR432W YDR432W NPL3 hom Verified 0.604831496567676 0.27264548179618 no 1319 0.301290705292343 1052 NA FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION NUCLEUS RNA-binding protein; promotes elongation, regulates termination, and carries poly(A) mRNA from nucleus to cytoplasm; has a role in repressing translation initiation by binding eIF4G; required for pre-mRNA splicing; dissociation from mRNAs promoted by Mtr10p; phosphorylated by Sky1p in the cytoplasm; protein abundance increases in response to DNA replication stress translational termination|mRNA export from nucleus|negative regulation of translation|mRNA splicing, via spliceosome|Unknown|positive regulation of transcription elongation from RNA polymerase II promoter mRNA binding|RNA polymerase II core binding|eukaryotic initiation factor 4G binding|poly(A) RNA binding nucleus|cytoplasm
YBR279W YBR279W PAF1 hom Verified 0.604594550089982 0.272724214358958 no 1320 0.356579585461441 1207 NA FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|RIBOSOME BIOGENESIS|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION|GENE SILENCING NUCLEUS|CHROMOSOME RNA POL II, HOLOENZYME Component of the Paf1p complex involved in transcription elongation; binds to and modulates the activity of RNA polymerases I and II; required for expression of a subset of genes, including cell cycle-regulated genes; involved in SER3 repression by helping to maintain SRG1 transcription-dependent nucleosome occupancy; homolog of human PD2/hPAF1 negative regulation of DNA recombination|mRNA 3'-end processing|snoRNA transcription from an RNA polymerase II promoter|regulation of transcription by chromatin organization|transcription from RNA polymerase I promoter|regulation of transcription-coupled nucleotide-excision repair|rRNA processing|transcription elongation from RNA polymerase I promoter|regulation of chromatin silencing at telomere|regulation of transcription from RNA polymerase II promoter|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of histone H3-K4 methylation|negative regulation of transcription from RNA polymerase II promoter|global genome nucleotide-excision repair|chromatin silencing at rDNA|Unknown|snoRNA 3'-end processing|transcription elongation from RNA polymerase II promoter|regulation of transcription involved in G1 phase of mitotic cell cycle RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity|chromatin binding|TFIIF-class binding transcription factor activity|RNA polymerase II core binding|RNA polymerase II transcription factor binding transcription factor activity transcriptionally active chromatin|nucleus|Cdc73/Paf1 complex
YML017W YML017W PSP2 hom Verified 0.603861459331878 0.272967877139711 no 1321 0.294080893201896 1034 NA Asn rich cytoplasmic protein that contains RGG motifs; high-copy suppressor of group II intron-splicing defects of a mutation in MRS2 and of a conditional mutation in POL1 (DNA polymerase alpha); possible role in mitochondrial mRNA splicing biological_process molecular_function cytoplasm
YJL029C YJL029C VPS53 hom Verified 0.603192728677632 0.273190242177962 no 1322 0.237283695263766 805 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT GOLGI APPARATUS Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; required for vacuolar protein sorting Golgi to vacuole transport|retrograde transport, endosome to Golgi molecular_function Golgi apparatus|GARP complex|cytoplasm
YBL028C YBL028C YBL028C hom Verified 0.602963240473749 0.273266571836068 no 1323 0.295115570592192 972 NA FT NUCLEUS Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis biological_process molecular_function ribosome|nucleolus|nucleus|preribosome, large subunit precursor
YJL166W YJL166W QCR8 hom Verified 0.602109563232098 0.273550604593577 no 1324 0.259202769369288 858 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p mitochondrial electron transport, ubiquinol to cytochrome c|aerobic respiration ubiquinol-cytochrome-c reductase activity mitochondrion|integral to membrane|mitochondrial respiratory chain complex III
YKL098W YKL098W MTC2 hom Verified 0.6005319991556 0.274075870841138 no 1325 0.3142534530225 1076 NA Protein of unknown function; mtc2 is synthetically sick with cdc13-1 biological_process molecular_function cellular_component
YDR420W YDR420W HKR1 hom Verified 0.5997102178285 0.274349688692863 no 1326 0.257405380365754 902 NA FT CELL CYCLE|SIGNALING|CELL WALL ORG/BIOGENESIS|CELL DIVISION|CARBOHYDRATE METABOLISM SITE OF POLARIZED GROWTH|PLASMA MEMBRANE Mucin family member that functions as an osmosensor in the Sho1p-mediated HOG pathway with Msb2p; proposed to be a negative regulator of filamentous growth; mutant displays defects in beta-1,3 glucan synthesis and bud site selection (1->3)-beta-D-glucan biosynthetic process|fungal-type cell wall organization|osmosensory signaling pathway via Sho1 osmosensor|hyperosmotic response|cellular bud site selection osmosensor activity site of polarized growth|plasma membrane
YOR222W YOR222W ODC2 hom Verified 0.599140096520411 0.274539732642252 no 1327 0.256677179794344 890 NA FT MITOCHONDRION Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for use in lysine and glutamate biosynthesis and in lysine catabolism mitochondrial transport dicarboxylic acid transmembrane transporter activity mitochondrion|integral to membrane|mitochondrial inner membrane
YKL123W_d YKL123W YKL123W hom Dubious 0.598533083770218 0.274742145330051 no 1328 0.28445574333014 959 NA Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene SSH4 Unknown Unknown Unknown
YER118C YER118C SHO1 hom Verified 0.597340897015738 0.275139902468878 no 1329 0.265372545807792 898 NA FT SIGNALING SITE OF POLARIZED GROWTH|PLASMA MEMBRANE Transmembrane osmosensor involved in activation of the Cdc42p- and MAP kinase-dependent filamentous growth pathway and the high-osmolarity glycerol response pathway; phosphorylated by Hog1p; interacts with Pbs2p, Msb2p, Hkr1p, and Ste11p signal transduction involved in filamentous growth|establishment of cell polarity|osmosensory signaling pathway|cellular response to heat|cytokinesis osmosensor activity|MAP-kinase scaffold activity integral to membrane|plasma membrane|plasma membrane part|cellular bud|cellular bud neck|mating projection tip
YBR157C YBR157C ICS2 hom Verified 0.597073009417824 0.275229318579491 no 1330 0.265269404564007 890 NA Protein of unknown function; null mutation does not confer any obvious defects in growth, spore germination, viability, or carbohydrate utilization biological_process molecular_function cellular_component
YNL252C YNL252C MRPL17 hom Verified 0.596621851346525 0.275379939437104 no 1331 0.273451396269779 940 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YFL011W YFL011W HXT10 hom Verified 0.595769144304077 0.275664729690455 no 1332 0.301359112477445 1034 NA FT MITOCHONDRION|PLASMA MEMBRANE Putative hexose transporter, expressed at low levels and expression is repressed by glucose hexose transport|transmembrane transport galactose transmembrane transporter activity|mannose transmembrane transporter activity|fructose transmembrane transporter activity|glucose transmembrane transporter activity mitochondrion|integral to membrane|plasma membrane
YCR088W YCR088W ABP1 hom Verified 0.594951347123387 0.275937996569944 no 1333 0.264109141194554 879 NA FT PROTEIN LOCALIZATION|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH|CYTOSKELETON Actin-binding protein of the cortical actin cytoskeleton, important for activation of the Arp2/3 complex that plays a key role actin in cytoskeleton organization; phosphorylation within its PRR (Proline-Rich Region), mediated by Cdc28p and Pho85p, protects Abp1p from proteolysis mediated by its own PEST sequences protein localization|actin cortical patch assembly actin filament binding cell cortex|mating projection tip|cytoplasm|actin cortical patch
YLL013C YLL013C PUF3 hom Verified 0.594270761923047 0.276165515471351 no 1334 0.275495326565036 941 NA FT OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY|RNA LOCALIZATION MITOCHONDRION Protein of the mitochondrial outer surface, links the Arp2/3 complex with the mitochore during anterograde mitochondrial movement; also binds to and promotes degradation of mRNAs for select nuclear-encoded mitochondrial proteins nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|nuclear-transcribed mRNA catabolic process|intracellular mRNA localization|mitochondrion organization|aerobic respiration|mitochondrion localization mRNA binding external side of mitochondrial outer membrane|cytoplasm
YJR043C YJR043C POL32 hom Verified 0.594033942739694 0.276244705458576 no 1335 0.296865127367555 1016 NA FT RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME Third subunit of DNA polymerase delta, involved in chromosomal DNA replication; required for error-prone DNA synthesis in the presence of DNA damage and processivity; interacts with Hys2p, PCNA (Pol30p), and Pol1p RNA-dependent DNA replication|lagging strand elongation|postreplication repair|base-excision repair|DNA replication, removal of RNA primer|nucleotide-excision repair|mismatch repair|double-strand break repair via break-induced replication|leading strand elongation DNA-directed DNA polymerase activity|single-stranded DNA specific 3'-5' exodeoxyribonuclease activity delta DNA polymerase complex|nucleus
YDR477W YDR477W SNF1 hom Verified 0.593671539042604 0.276365911231044 no 1336 0.273230003365092 894 NA FT KETONE METABOLISM|SIGNALING|TRANSLATION|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION AMP-activated serine/threonine protein kinase; found in a complex containing Snf4p and members of the Sip1p/Sip2p/Gal83p family; required for transcription of glucose-repressed genes, thermotolerance, sporulation, and peroxisome biogenesis; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p; regulates filamentous growth in response to starvation negative regulation of translation|protein phosphorylation|replicative cell aging|signal transduction|biofilm formation|positive regulation of gluconeogenesis|pseudohyphal growth|cell adhesion|regulation of carbohydrate metabolic process|invasive growth in response to glucose limitation|cellular response to nitrogen starvation AMP-activated protein kinase activity|protein kinase activity mitochondrion|AMP-activated protein kinase complex|nucleus|nuclear envelope lumen|fungal-type vacuole|cytoplasm
YPR009W YPR009W SUT2 hom Verified 0.592390014472942 0.27679472571606 no 1337 0.29056505429433 965 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; highly similar to Sut1p positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter RNA polymerase II repressing transcription factor binding|sequence-specific DNA binding nucleus
YDR524C YDR524C AGE1 hom Verified 0.591609774235441 0.277055963588762 no 1338 0.204420045202603 703 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING|NUCLEOTIDE METABOLISM GOLGI APPARATUS ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector, involved in the secretory and endocytic pathways; contains C2C2H2 cysteine/histidine motif ER to Golgi vesicle-mediated transport|intra-Golgi vesicle-mediated transport phospholipid binding|ARF GTPase activator activity endosome|trans-Golgi network|cytoplasm
YOL164W YOL164W BDS1 hom Verified 0.589480601486837 0.277769460663229 no 1339 0.294915128822743 998 NA Bacterially-derived sulfatase required for use of alkyl- and aryl-sulfates as sulfur sources dodecyl sulfate metabolic process arylsulfatase activity|alkyl sulfatase activity cellular_component
YER134C YER134C YER134C hom Verified 0.589235690382272 0.277851589176814 no 1340 0.276535966584765 962 NA FT NUCLEUS Magnesium-dependent acid phosphatase, member of the haloacid dehalogenase superfamily; non-essential gene biological_process acid phosphatase activity nucleus|cytoplasm
YHL012W_p YHL012W YHL012W hom Uncharacterized 0.588617830190149 0.278058835136189 no 1341 0.24705228688852 844 NA Putative UTP glucose-1-phosphate uridylyltransferase; YHL012W has a paralog, UGP1, that arose from the whole genome duplication biological_process molecular_function cellular_component
YOR297C YOR297C TIM18 hom Verified 0.588420461445379 0.278125053501971 no 1342 0.249716269025592 862 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS MITOCHONDRION Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; may mediate assembly or stability of the complex cellular response to oxidative stress|protein import into mitochondrial inner membrane|apoptotic process|response to acid|response to osmotic stress|response to arsenic-containing substance protein channel activity mitochondrion|integral to membrane|mitochondrial inner membrane protein insertion complex
YFL030W YFL030W AGX1 hom Verified 0.587711216693285 0.278363072718463 no 1343 0.270527033344921 910 NA FT KETONE METABOLISM|AMINO ACID METABOLISM MITOCHONDRION Alanine:glyoxylate aminotransferase (AGT), catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast; has similarity to mammalian and plant alanine:glyoxylate aminotransferases glycine biosynthetic process, by transamination of glyoxylate alanine-glyoxylate transaminase activity mitochondrion
YDR135C YDR135C YCF1 hom Verified 0.586998470167431 0.278602367084321 no 1344 0.254543328120568 882 NA FT NUCLEOTIDE METABOLISM Vacuolar glutathione S-conjugate transporter; member of the ATP-binding cassette family; has a role in detoxifying metals such as cadmium, mercury, and arsenite; also transports unconjugated bilirubin, selenodigluthatione, and oxidized glutathione; similar to human cystic fibrosis protein CFTR bilirubin transport|response to metal ion|transmembrane transport bilirubin transmembrane transporter activity|glutathione S-conjugate-exporting ATPase activity fungal-type vacuole membrane|integral to membrane
YOR104W YOR104W PIN2 hom Verified 0.586716455600915 0.278697077061253 no 1345 0.288175032792349 970 NA Protein that induces appearance of [PIN+] prion when overproduced; predicted to be palmitoylated biological_process molecular_function cellular_component
YGR118W YGR118W RPS23A hom Verified 0.585638251153721 0.279059318837057 no 1346 0.287284332200873 980 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit, required for translational accuracy; homologous to mammalian ribosomal protein S23 and bacterial S12; RPS23A has a paralog, RPS23B, that arose from the whole genome duplication; deletion of both RPS23A and RPS23B is lethal maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|regulation of translational fidelity structural constituent of ribosome cytosolic small ribosomal subunit
YDL045W-A YDL045W-A MRP10 hom Verified 0.585267489200918 0.279183935727121 no 1347 0.309867574577191 1061 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the small subunit; contains twin cysteine-x9-cysteine motifs mitochondrial translation|mitochondrial respiratory chain complex assembly structural constituent of ribosome mitochondrial small ribosomal subunit
YKL119C YKL119C VPH2 hom Verified 0.583236194866852 0.279867154225329 no 1348 0.288614381462438 981 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|ION HOMEOSTASIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Integral membrane protein required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the endoplasmic reticulum (ER) vacuolar proton-transporting V-type ATPase complex assembly|vacuolar acidification molecular_function endoplasmic reticulum membrane
YCL032W YCL032W STE50 hom Verified 0.582066881118312 0.280260816093336 no 1349 0.288284962022817 986 NA FT CELL CYCLE|SIGNALING Protein involved in mating response, invasive/filamentous growth, and osmotolerance, acts as an adaptor that links G protein-associated Cdc42p-Ste20p complex to the effector Ste11p to modulate signal transduction pheromone-dependent signal transduction involved in conjugation with cellular fusion|MAPK cascade involved in osmosensory signaling pathway|osmosensory signaling pathway via Sho1 osmosensor|signal transduction involved in filamentous growth|cellular response to heat SAM domain binding|protein kinase regulator activity cytoplasm
YLR366W_d YLR366W YLR366W hom Dubious 0.579548623780925 0.281109523825515 no 1350 0.277444387269358 929 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR364C-A Unknown Unknown Unknown
YDR252W YDR252W BTT1 hom Verified 0.579481203237471 0.281132263074683 no 1351 0.278138856722431 930 NA FT PROTEIN LOCALIZATION NUCLEUS Beta3 subunit of the heterotrimeric nascent polypeptide-associated complex which binds ribosomes via its beta-subunits in close proximity to nascent polypeptides; interacts with Caf130p of the CCR4-NOT complex; similar to human BTF3 'de novo' cotranslational protein folding unfolded protein binding nascent polypeptide-associated complex|CCR4-NOT complex
YGL084C YGL084C GUP1 hom Verified 0.578511123855655 0.281459544708953 no 1352 0.390521287596662 1302 NA FF|FT LIPID METABOLISM|CARBOHYDRATE METABOLISM ENDOPLASMIC RETICULUM|PLASMA MEMBRANE Plasma membrane protein involved in remodeling GPI anchors; member of the MBOAT family of putative membrane-bound O-acyltransferases; proposed to be involved in glycerol transport GPI anchor biosynthetic process|glycerol transport|glycerol catabolic process O-acyltransferase activity integral to membrane|endoplasmic reticulum|plasma membrane|membrane
YLR238W YLR238W FAR10 hom Verified 0.578232140966635 0.281553700903023 no 1353 0.274570225582647 931 NA FT CELL CYCLE|SIGNALING ENDOPLASMIC RETICULUM Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far8p, Far9p, and Far11p; potential Cdc28p substrate re-entry into mitotic cell cycle after pheromone arrest molecular_function endoplasmic reticulum
YPL065W YPL065W VPS28 hom Verified 0.577894824163284 0.281667564968265 no 1354 0.299425308021686 1054 NA FF|FT PROTEIN LOCALIZATION|PROTEOLYSIS|VACUOLAR TRANSPORT Component of the ESCRT-I complex (Stp22p, Srn2p, Vps28p, and Mvb12p), which is involved in ubiquitin-dependent sorting of proteins into the endosome; conserved C-terminal domain interacts with ESCRT-III subunit Vps20p protein targeting to membrane|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|protein targeting to vacuole protein complex binding endosome|ESCRT I complex
YLR131C YLR131C ACE2 hom Verified 0.577847887880534 0.281683410456573 no 1355 0.41636742724553 1388 NA FF|FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CELL DIVISION NUCLEUS Transcription factor required for septum destruction after cytokinesis; phosphorylation by Cbk1p blocks nuclear exit during M/G1 transition, causing localization to daughter cell nuclei, and also increases Ace2p activity; phosphorylation by Cdc28p and Pho85p prevents nuclear import during cell cycle phases other than cytokinesis; part of RAM network that regulates cellular polarity and morphogenesis; ACE2 has a paralog, SWI5, that arose from the whole genome duplication Unknown|regulation of transcription involved in G1 phase of mitotic cell cycle RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity|core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding cytosol|nucleus
YKL009W YKL009W MRT4 hom Verified 0.576410445308308 0.282168892933397 no 1356 0.297661373737432 1003 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Protein involved in mRNA turnover and ribosome assembly, localizes to the nucleolus nuclear-transcribed mRNA catabolic process|ribosomal large subunit assembly|ribosomal large subunit biogenesis|rRNA processing LSU rRNA binding nucleoplasm|nucleolus|nucleus|preribosome, large subunit precursor
YGL143C YGL143C MRF1 hom Verified 0.574759016094271 0.282727144045026 no 1357 0.33189308546823 1122 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial translation release factor, involved in stop codon recognition and hydrolysis of the peptidyl-tRNA bond during mitochondrial translation; lack of MRF1 causes mitochondrial genome instability translational termination|mitochondrial translational termination|mitochondrial translation translation release factor activity mitochondrion
YGR097W YGR097W ASK10 hom Verified 0.574487020928339 0.282819140491577 no 1358 0.288192132129217 1010 NA FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO OXIDATIVE STRESS NUCLEUS RNA POL II, HOLOENZYME Component of RNA polymerase II holoenzyme; phosphorylated in response to oxidative stress; has a role in destruction of Ssn8p; proposed to function in activation of the glycerol channel Fps1p; ASK10 has a paralog, RGC1, that arose from the whole genome duplication cellular protein catabolic process|cellular response to oxidative stress|positive regulation of transcription from RNA polymerase II promoter|positive regulation of glycerol transport molecular_function DNA-directed RNA polymerase II, holoenzyme|cytoplasm
YOR325W_d YOR325W YOR325W hom Dubious 0.573531356795842 0.28314248705258 no 1359 0.286200150244666 992 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF FRT1 Unknown Unknown Unknown
YLR334C_d YLR334C YLR334C hom Dubious 0.571635640828344 0.283784422211495 no 1360 0.257526394808388 859 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps a stand-alone long terminal repeat sequence whose presence indicates a retrotransposition event occurred here Unknown Unknown Unknown
YHR050W-A_p YHR050W-A YHR050W-A hom Uncharacterized 0.569797463590112 0.284407538031606 no 1361 0.286076376989784 976 NA Protein of unknown function; identified by expression profiling and mass spectrometry biological_process molecular_function cellular_component
YPR122W YPR122W AXL1 hom Verified 0.569466721652679 0.284519724179827 no 1362 0.272458237595986 943 NA FT CELL CYCLE|CELL DIVISION|PROTEOLYSIS SITE OF POLARIZED GROWTH Haploid specific endoprotease that performs one of two N-terminal cleavages during maturation of a-factor mating pheromone; required for axial budding pattern of haploid cells peptide pheromone maturation|axial cellular bud site selection metalloendopeptidase activity mating projection tip|cellular bud neck
YNL231C YNL231C PDR16 hom Verified 0.569020621022179 0.284671072939146 no 1363 0.302048461442069 1044 NA FF|FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Phosphatidylinositol transfer protein (PITP); controlled by the multiple drug resistance regulator Pdr1p; localizes to lipid particles and microsomes; controls levels of various lipids, may regulate lipid synthesis; homologous to Pdr17p; protein abundance increases in response to DNA replication stress response to drug|sterol biosynthetic process|phospholipid biosynthetic process|phospholipid transport phosphatidylinositol transporter activity|phosphatidylcholine transporter activity cell periphery|lipid particle|plasma membrane|cytoplasm
YIL146C YIL146C ATG32 hom Verified 0.568936037403211 0.284699773995122 no 1364 0.259224162520985 885 NA FT CELL WALL ORG/BIOGENESIS MITOCHONDRION Mitochondrial outer membrane protein required to initiate mitophagy; recruits the autophagy adaptor protein Atg11p and the ubiquitin-like protein Atg8p to the mitochondrial surface to initiate mitophagy, the selective vacuolar degradation of mitochondria in response to starvation; can promote pexophagy when placed ectopically in the peroxisomal membrane fungal-type cell wall organization|mitochondrion degradation molecular_function integral to mitochondrial outer membrane
YIL093C YIL093C RSM25 hom Verified 0.568927082240274 0.284702812756945 no 1365 0.29315430240814 1016 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the small subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial small ribosomal subunit
YGL095C YGL095C VPS45 hom Verified 0.568623016015198 0.284806000952181 no 1366 0.357695906596345 1206 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Protein of the Sec1p/Munc-18 family, essential for vacuolar protein sorting; required for the function of Pep12p and the early endosome/late Golgi SNARE Tlg2p; essential for fusion of Golgi-derived vesicles with the prevacuolar compartment vacuole inheritance|CVT pathway|positive regulation of SNARE complex assembly|Golgi vesicle fusion to target membrane|Golgi to vacuole transport|vacuole organization|vacuolar acidification|protein targeting to vacuole|Golgi to endosome transport unfolded protein binding|SNARE binding cytosol|SNARE complex|Golgi membrane|extrinsic to membrane
YHR199C YHR199C AIM46 hom Verified 0.568408991750359 0.284878643124409 no 1367 0.361718453169844 1197 NA FT KETONE METABOLISM|AMINO ACID METABOLISM MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss biological_process molecular_function mitochondrion
YLR377C YLR377C FBP1 hom Verified 0.567880865499092 0.285057932746059 no 1368 0.288570649384054 978 NA FT CARBOHYDRATE METABOLISM Fructose-1,6-bisphosphatase, key regulatory enzyme in the gluconeogenesis pathway, required for glucose metabolism; undergoes either proteasome-mediated or autophagy-mediated degradation depending on growth conditions; interacts with Vid30p gluconeogenesis|reactive oxygen species metabolic process fructose 1,6-bisphosphate 1-phosphatase activity cytosol
YFR047C YFR047C BNA6 hom Verified 0.567846830214894 0.285069488974481 no 1369 0.281203583052843 950 NA FT NUCLEOTIDE METABOLISM|COFACTOR METABOLISM NUCLEUS Quinolinate phosphoribosyl transferase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p de novo NAD biosynthetic process from tryptophan nicotinate-nucleotide diphosphorylase (carboxylating) activity nucleus|cytoplasm
YML055W YML055W SPC2 hom Verified 0.5661501501176 0.285645857050929 no 1370 0.304130794467347 1052 NA FT PROTEIN LOCALIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Subunit of signal peptidase complex (Spc1p, Spc2p, Spc3p, Sec11p), which catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC25 signal peptide processing|protein targeting to ER peptidase activity signal peptidase complex
YIR018C-A_p YIR018C-A YIR018C-A hom Uncharacterized 0.565414390593504 0.285895969345303 no 1371 0.276086018226068 935 NA Putative protein of unknown function; identified by expression profiling and mass spectrometry biological_process molecular_function cellular_component
YDR245W YDR245W MNN10 hom Verified 0.565332619391921 0.285923772875254 no 1372 0.288182425586811 988 NA FT CELL WALL ORG/BIOGENESIS|CELL DIVISION|CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS Subunit of a Golgi mannosyltransferase complex also containing Anp1p, Mnn9p, Mnn11p, and Hoc1p that mediates elongation of the polysaccharide mannan backbone; membrane protein of the mannosyltransferase family N-glycan processing|cell wall mannoprotein biosynthetic process|substituted mannan metabolic process|barrier septum assembly alpha-1,6-mannosyltransferase activity alpha-1,6-mannosyltransferase complex
YKR045C_p YKR045C YKR045C hom Uncharacterized 0.563162276578483 0.286662193898649 no 1373 0.287519623983647 968 NA Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm biological_process molecular_function cytoplasm
YLR307C-A_p YLR307C-A YLR307C-A hom Uncharacterized 0.560940631871177 0.287419004834097 no 1374 0.269007047744272 898 NA Putative protein of unknown function biological_process molecular_function cellular_component
YBR084C-A YBR084C-A RPL19A hom Verified 0.560691319582644 0.287503992867847 no 1375 0.271833556600371 932 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L19A; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal; homologous to mammalian ribosomal protein L19, no bacterial homolog; RPL19A has a paralog, RPL19B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YOL056W YOL056W GPM3 hom Verified 0.560238987107001 0.287658218757237 no 1376 0.287412322394196 983 NA FT CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY Homolog of Gpm1p phosphoglycerate mutase, which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event biological_process phosphoglycerate mutase activity|molecular_function cytosol
YML042W YML042W CAT2 hom Verified 0.558904322306569 0.288113509700766 no 1377 0.278457223322571 918 NA FT KETONE METABOLISM|LIPID METABOLISM|AMINO ACID METABOLISM MITOCHONDRION Carnitine acetyl-CoA transferase present in both mitochondria and peroxisomes, transfers activated acetyl groups to carnitine to form acetylcarnitine which can be shuttled across membranes carnitine metabolic process carnitine O-acetyltransferase activity mitochondrion|peroxisomal matrix|peroxisome
YKL093W YKL093W MBR1 hom Verified 0.557900834657511 0.288456050776064 no 1378 0.27940775498971 999 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Protein involved in mitochondrial functions and stress response; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants aerobic respiration molecular_function cellular_component
YBR078W YBR078W ECM33 hom Verified 0.557229883116078 0.288685187484405 no 1379 0.367171333621638 1200 NA FF|FT CELL WALL ORG/BIOGENESIS MITOCHONDRION|PLASMA MEMBRANE GPI-anchored protein of unknown function, has a possible role in apical bud growth; GPI-anchoring on the plasma membrane crucial to function; phosphorylated in mitochondria; similar to Sps2p and Pst1p fungal-type cell wall organization molecular_function mitochondrion|fungal-type cell wall|plasma membrane
YDL239C YDL239C ADY3 hom Verified 0.557149786898165 0.288712546875751 no 1380 0.28539314454648 939 NA FT CELL CYCLE|CELL WALL ORG/BIOGENESIS|CELL DIVISION|MITOCHONDRION ORGANIZATION NUCLEUS|CYTOSKELETON Protein required for spore wall formation; thought to mediate assembly of a Don1p-containing structure at the leading edge of the prospore membrane via interaction with spindle pole body components; potentially phosphorylated by Cdc28p; ADY3 has a paralog, CNM67, that arose from the whole genome duplication mitochondrion inheritance|ascospore wall assembly|sporulation resulting in formation of a cellular spore molecular_function spindle pole body|prospore membrane
YDR014W YDR014W RAD61 hom Verified 0.555821475908537 0.289166451350846 no 1381 0.307735390171939 1046 NA FT CELL CYCLE|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME Subunit of a complex (Scc3p, Pds5p, Rad61p) that inhibits sister chromatid cohesion; inhibited by Eco1p-acetylated cohesin subunits Smc3p and Mcd1p; related to the human Wapl protein that controls the association of cohesin with chromatin mitotic sister chromatid cohesion molecular_function nuclear cohesin complex
YOR202W YOR202W HIS3 hom Verified 0.555455522305378 0.289291562301661 no 1382 0.262935299416226 921 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p histidine biosynthetic process imidazoleglycerol-phosphate dehydratase activity cellular_component
YOR285W YOR285W RDL1 hom Verified 0.555187328780644 0.289383267525937 no 1383 0.274298610409327 935 NA FT ENDOPLASMIC RETICULUM|MITOCHONDRION Protein of unknown function containing a rhodanese-like domain; localized to the mitochondrial outer membrane; protein abundance increases in response to DNA replication stress biological_process molecular_function mitochondrial outer membrane|mitochondrion|endoplasmic reticulum
YNL281W YNL281W HCH1 hom Verified 0.55373161199349 0.289881268707188 no 1384 0.255708353863734 881 NA FT NUCLEOTIDE METABOLISM NUCLEUS Heat shock protein regulator; binds to Hsp90p and may stimulate ATPase activity; originally identified as a high-copy number suppressor of a HSP90 loss-of-function mutation; GFP-fusion protein localizes to the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress protein folding|response to stress ATPase activator activity|chaperone binding nucleus|cytoplasm
YPL118W YPL118W MRP51 hom Verified 0.549770749366069 0.291238311840551 no 1385 0.311489764059103 1089 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the small subunit; MRP51 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequences mitochondrial translational initiation|mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial small ribosomal subunit
YDL109C_p YDL109C YDL109C hom Uncharacterized 0.549663748362865 0.291275012882652 no 1386 0.310764863925772 1076 NA FT LIPID METABOLISM Putative lipase; involved in lipid metabolism; not an essential gene; YDL109C has a paralog, ROG1, that arose from the whole genome duplication cellular lipid metabolic process molecular_function cellular_component
YDR465C YDR465C RMT2 hom Verified 0.549305138599277 0.291398030758142 no 1387 0.316318842462343 1052 NA FT NUCLEUS Arginine N5 methyltransferase; methylates ribosomal protein Rpl12 (L12) on Arg67; relative distribution to the nucleus increases upon DNA replication stress peptidyl-arginine methylation protein-arginine N5-methyltransferase activity nucleus|cytoplasm
YDR507C YDR507C GIN4 hom Verified 0.547584710649491 0.291988545033137 no 1388 0.306059358472982 1047 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION SITE OF POLARIZED GROWTH Protein kinase involved in bud growth and assembly of the septin ring; proposed to have kinase-dependent and kinase-independent activities; undergoes autophosphorylation; similar to Hsl1p; GIN4 has a paralog, KCC4, that arose from the whole genome duplication protein autophosphorylation|budding cell bud growth|protein phosphorylation|septin checkpoint|septin ring assembly protein kinase activity cellular bud neck
YDR310C YDR310C SUM1 hom Verified 0.546642692314423 0.292312116328791 no 1389 0.310105051238052 1059 NA FT TRANSCRIPTION FROM RNA POL II|GENE SILENCING NUCLEUS Transcriptional repressor required for mitotic repression of middle sporulation-specific genes; also acts as general replication initiation factor; involved in telomere maintenance, chromatin silencing; regulated by pachytene checkpoint negative regulation of transcription by competitive promoter binding|negative regulation of transcription from RNA polymerase II promoter during mitosis|DNA replication initiation|chromatin silencing at silent mating-type cassette DNA replication origin binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding nucleus
YNL297C YNL297C MON2 hom Verified 0.546178554390069 0.292471603092824 no 1390 0.334549886754996 1127 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Peripheral membrane protein with a role in endocytosis and vacuole integrity, interacts with Arl1p and localizes to the endosome; member of the Sec7p family of proteins transport|endocytosis|protein targeting to vacuole|Golgi to endosome transport guanyl-nucleotide exchange factor activity cytosol|endosome|trans-Golgi network|extrinsic to membrane
YDR445C_d YDR445C YDR445C hom Dubious 0.54452189587187 0.293041192557683 no 1391 0.315701738853247 1083 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YJL214W YJL214W HXT8 hom Verified 0.542374579530399 0.293780243953313 no 1392 0.289434180883616 984 NA FT PLASMA MEMBRANE Protein of unknown function with similarity to hexose transporter family members, expression is induced by low levels of glucose and repressed by high levels of glucose hexose transport mannose transmembrane transporter activity|glucose transmembrane transporter activity|fructose transmembrane transporter activity integral to membrane|plasma membrane
YER028C YER028C MIG3 hom Verified 0.542310218622162 0.293802408638427 no 1393 0.290577703395245 985 NA FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME Transcriptional regulator; partially nonfunctional in S288C strains but has a major role in catabolite repression and ethanol response in some other strains; involved in response to toxic agents; phosphorylation by Snf1p or the Mec1p pathway inactivates Mig3p, allowing induction of damage response genes; MIG3 has a paralog, MIG2, that arose from the whole genome duplication cellular response to UV|negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage|response to DNA damage stimulus RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding nuclear chromatin
YML081W YML081W TDA9 hom Verified 0.541996220209242 0.293910554873394 no 1394 0.277022007429285 945 NA FT NUCLEUS DNA-binding protein, putative transcription factor; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; null mutant is sensitive to expression of the top1-T722A allele; not an essential gene; TDA9 has a paralog, RSF2, that arose from the whole genome duplication biological_process sequence-specific DNA binding nucleus
YGL232W YGL232W TAN1 hom Verified 0.541720807872821 0.294005426579778 no 1395 0.300201534690012 1008 NA FT RNA PROCESSING NUCLEUS Putative tRNA acetyltransferase; RNA-binding protein required for the formation of the modified nucleoside N(4)-acetylcytidine in serine and leucine tRNAs but not required for the same modification in 18S rRNA; protein abundance increases in response to DNA replication stress tRNA modification RNA binding nucleus|cytoplasm
YHR021W-A_p YHR021W-A ECM12 hom Uncharacterized 0.540266715102692 0.294506554670717 no 1396 0.287330780881468 1002 NA FT CELL WALL ORG/BIOGENESIS Putative protein of unknown function; may contribute to cell wall biosynthesis, mutants display zymolyase hypersensitivity fungal-type cell wall organization molecular_function cellular_component
YOL019W-A_p YOL019W-A YOL019W-A hom Uncharacterized 0.540034537814547 0.29458660706657 no 1397 0.284745305856949 958 NA Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching biological_process molecular_function cellular_component
YNL146W_p YNL146W YNL146W hom Uncharacterized 0.539804651340384 0.294665879502618 no 1398 0.301135224906774 1040 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YNL146W is not an essential gene biological_process molecular_function endoplasmic reticulum
YGR085C YGR085C RPL11B hom Verified 0.53911534474656 0.294903634106075 no 1399 0.322718126547274 1095 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Ribosomal 60S subunit protein L11B; expressed at half the level of Rpl11Ap; involved in ribosomal assembly; depletion causes degradation of 60S proteins and RNA; homologous to mammalian ribosomal protein L11 and bacterial L5; RPL11B has a paralog, RPL11A, that arose from the whole genome duplication cytoplasmic translation|ribosomal large subunit assembly structural constituent of ribosome cytosolic large ribosomal subunit
YDR471W YDR471W RPL27B hom Verified 0.539039224742063 0.294929894724237 no 1400 0.290720368412513 978 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L27B; homologous to mammalian ribosomal protein L27, no bacterial homolog; RPL27B has a paralog, RPL27A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YGR150C YGR150C CCM1 hom Verified 0.537801721903613 0.295356971545606 no 1401 0.309323317802555 1026 NA FT RNA PROCESSING|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial 15s rRNA-binding protein; required for intron removal of COB and COX1 pre-mRNAs; contains pentatricopeptide repeat (PPR) motifs; mutant is respiratory deficient and has defective plasma membrane electron transport rRNA metabolic process|mitochondrial RNA processing|mitochondrial genome maintenance rRNA binding mitochondrion
YCR090C_p YCR090C YCR090C hom Uncharacterized 0.535292533608751 0.296223794248688 no 1402 0.24794769876359 843 NA FT NUCLEUS Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YCR090C is not an essential gene biological_process molecular_function nucleus|cytoplasm
YLR047C YLR047C FRE8 hom Verified 0.535013549487619 0.296320243978907 no 1403 0.328483121657096 1110 NA FT ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|GEN. OF PRECURSOR METABOLITES AND ENERGY Protein with sequence similarity to iron/copper reductases, involved in iron homeostasis; deletion mutant has iron deficiency/accumulation growth defects; expression increased in the absence of copper-responsive transcription factor Mac1p cellular metal ion homeostasis oxidoreductase activity, oxidizing metal ions integral to membrane|membrane
YNL228W_d YNL228W YNL228W hom Dubious 0.534994616439555 0.296326789989225 no 1404 0.316163085214061 1068 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps ORF YNL227C/JJJ1 Unknown Unknown Unknown
YMR114C YMR114C YMR114C hom Verified 0.533407501613922 0.296875762889252 no 1405 0.290259656696393 981 NA FT NUCLEUS Protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; YMR114C is not an essential gene biological_process molecular_function ribosome|nucleus|cytoplasm
YGR071C YGR071C ENV11 hom Verified 0.529608290571621 0.298191772503063 no 1406 0.285627052466581 969 NA FT VACUOLAR PROTEIN PROCESSING NUCLEUS Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and fragmented vacuoles; deletion mutant has increased glycogen accumulation and displays elongated buds; green fluorescent protein (GFP)-fusion protein localizes to the nucleus vacuole organization|vacuolar protein processing molecular_function nucleus
YOL003C YOL003C PFA4 hom Verified 0.529452646066093 0.298245742852093 no 1407 0.299485781754867 1016 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases protein palmitoylation palmitoyltransferase activity integral to membrane|endoplasmic reticulum
YJL075C_d YJL075C APQ13 hom Dubious 0.529374214861416 0.298272940868473 no 1408 0.299862718289498 1016 NA Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 85% of ORF overlaps the verified gene NET1; null mutant is sensitive to sorbate Unknown Unknown Unknown
YDL160C YDL160C DHH1 hom Verified 0.528813956276345 0.298467257629807 no 1409 0.324276968832769 1107 NA FF|FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|TRANSLATION|RNA LOCALIZATION Cytoplasmic DExD/H-box helicase, stimulates mRNA decapping; coordinates distinct steps in mRNA function and decay, interacts with both the decapping and deadenylase complexes, may have a role in mRNA export and translation; C-terminus of Dhh1p interacts with Ngr1p and promotes POR1, but not EDC1 mRNA decay; forms cytoplasmic foci upon DNA replication stress deadenylation-dependent decapping of nuclear-transcribed mRNA|cell morphogenesis involved in conjugation with cellular fusion|stress granule assembly|cytoplasmic mRNA processing body assembly protein binding|RNA helicase activity cytoplasmic mRNA processing body|cytoplasmic stress granule|cytoplasm
YBL054W YBL054W TOD6 hom Verified 0.528424987069939 0.29860219926714 no 1410 0.287858189831806 997 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS|CHROMOSOME PAC motif binding protein involved in rRNA and ribosome biogenesis; subunit of the RPD3L histone deacetylase complex; Myb-like HTH transcription factor; hypophosphorylated by rapamycin treatment in a Sch9p-dependent manner; TOD6 has a paralog, DOT6, that arose from the whole genome duplication regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding Rpd3L-Expanded complex|nucleus|Rpd3L complex|cytoplasm
YNL079C YNL079C TPM1 hom Verified 0.5278694094229 0.298794988995376 no 1411 0.299336319421472 1037 NA FF|FT VESICLE-MEDIATED TRANSPORT|CELL DIVISION|MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION|RNA LOCALIZATION SITE OF POLARIZED GROWTH|CYTOSKELETON Major isoform of tropomyosin; binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; acetylated by the NatB complex and acetylated form binds actin most efficiently; TPM1 has a paralog, TPM2, that arose from the whole genome duplication vacuole inheritance|exocytosis|intracellular mRNA localization|filamentous growth|budding cell apical bud growth|mitochondrion inheritance|budding cell isotropic bud growth|actin polymerization or depolymerization|actin filament organization|pseudohyphal growth|vesicle-mediated transport|establishment of cell polarity|actin filament bundle assembly actin lateral binding cellular bud neck contractile ring|actin filament bundle
YGR142W YGR142W BTN2 hom Verified 0.527175662870894 0.299035803785955 no 1412 0.298618380065154 1023 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|ION HOMEOSTASIS|ION HOMEOSTASIS v-SNARE binding protein; facilitates specific protein retrieval from a late endosome to the Golgi; modulates arginine uptake, possible role in mediating pH homeostasis between the vacuole and plasma membrane H(+)-ATPase; BTN2 has a paralog, CUR1, that arose from the whole genome duplication intracellular protein transport|amino acid transport|retrograde transport, endosome to Golgi|regulation of pH SNARE binding cytosol|late endosome|perinuclear region of cytoplasm
YIL023C YIL023C YKE4 hom Verified 0.526908719666742 0.299128489156605 no 1413 0.26993617366649 883 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Zinc transporter; localizes to the ER; null mutant is sensitive to calcofluor white, leads to zinc accumulation in cytosol; ortholog of the mouse KE4 and member of the ZIP (ZRT, IRT-like Protein) family zinc ion transport zinc ion transmembrane transporter activity integral to membrane|endoplasmic reticulum
YNL080C YNL080C EOS1 hom Verified 0.525864196142422 0.299491283521272 no 1414 0.315888333827842 1059 NA FT CARBOHYDRATE METABOLISM|RESPONSE TO OXIDATIVE STRESS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Protein involved in N-glycosylation; deletion mutation confers sensitivity to exidative stress and shows synthetic lethality with mutations in the spindle checkpoint genes BUB3 and MAD1; YNL080C is not an essential gene cellular response to oxidative stress|protein N-linked glycosylation molecular_function integral to membrane|endoplasmic reticulum membrane
YGR271C-A YGR271C-A EFG1 hom Verified 0.525840428331282 0.29949954111585 no 1415 0.342445045817478 1161 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Essential protein required for maturation of 18S rRNA; null mutant is sensitive to hydroxyurea and is delayed in recovering from alpha-factor arrest; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus G1 phase of mitotic cell cycle|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) molecular_function nucleolus
YDL037C YDL037C BSC1 hom Verified 0.525293270350145 0.299689667451507 no 1416 0.296219871652509 1028 NA Protein of unconfirmed function, similar to cell surface flocculin Flo11p; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression biological_process molecular_function cellular_component
YGR194C YGR194C XKS1 hom Verified 0.524076770903359 0.30011257218787 no 1417 0.275371730536468 943 NA FT CARBOHYDRATE METABOLISM Xylulokinase, converts D-xylulose and ATP to xylulose 5-phosphate and ADP; rate limiting step in fermentation of xylulose; required for xylose fermentation by recombinant S. cerevisiae strains xylulose catabolic process xylulokinase activity cytoplasm
YDL082W YDL082W RPL13A hom Verified 0.523993642489068 0.300141480859022 no 1418 0.260689567630003 914 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L13A; not essential for viability; homologous to mammalian ribosomal protein L13, no bacterial homolog; RPL13A has a paralog, RPL13B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YDL049C YDL049C KNH1 hom Verified 0.522725935072151 0.300582493724541 no 1419 0.288275257540142 1004 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM Protein with similarity to Kre9p, which is involved in cell wall beta 1,6-glucan synthesis; overproduction suppresses growth defects of a kre9 null mutant; required for propionic acid resistance (1->6)-beta-D-glucan biosynthetic process molecular_function fungal-type cell wall|extracellular region
YMR042W YMR042W ARG80 hom Verified 0.522593347491916 0.300628635481271 no 1420 0.298411350877374 1010 NA FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS Transcription factor involved in regulation of arginine-responsive genes; acts with Arg81p and Arg82p Unknown|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity|core promoter proximal region sequence-specific DNA binding nucleus
YIL166C_p YIL166C YIL166C hom Uncharacterized 0.522079424659776 0.300807515792679 no 1421 0.30067571707594 1012 NA Putative protein with similarity to the allantoate permease (Dal5p) subfamily of the major facilitator superfamily; mRNA expression is elevated by sulfur limitation; YIL166C is a non-essential gene transport transporter activity integral to membrane|membrane
YJL060W YJL060W BNA3 hom Verified 0.522020634799044 0.30082798174726 no 1422 0.301925232725038 1007 NA FT KETONE METABOLISM|AMINO ACID METABOLISM MITOCHONDRION Kynurenine aminotransferase, catalyzes formation of kynurenic acid from kynurenine; potential Cdc28p substrate kynurenic acid biosynthetic process arylformamidase activity|kynurenine-oxoglutarate transaminase activity mitochondrion|cytoplasm
YPL102C_d YPL102C YPL102C hom Dubious 0.521374907578536 0.301052813943 no 1423 0.296479353154085 1005 NA Dubious open reading frame, not conserved in closely related Saccharomyces species; deletion mutation enhances replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene ELP4 Unknown Unknown Unknown
YDR084C YDR084C TVP23 hom Verified 0.521051551122592 0.301165430093948 no 1424 0.267982080132646 929 NA FT VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern vesicle-mediated transport molecular_function integral to membrane|integral to Golgi membrane|cytoplasm
YDR441C YDR441C APT2 hom Verified 0.520568078549914 0.301333845673847 no 1425 0.29625744293634 985 NA Potential adenine phosphoribosyltransferase; encodes a protein with similarity to adenine phosphoribosyltransferase, but artificially expressed protein exhibits no enzymatic activity; APT2 has a paralog, APT1, that arose from the whole genome duplication biological_process adenine phosphoribosyltransferase activity|molecular_function cytoplasm
YAL066W_d YAL066W YAL066W hom Dubious 0.519509114132535 0.301702879425109 no 1426 0.321492135123039 1076 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YPL226W YPL226W NEW1 hom Verified 0.51914202443581 0.301830852279029 no 1427 0.274362173417706 968 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|NUCLEOTIDE METABOLISM|RNA LOCALIZATION NUCLEUS|MITOCHONDRION ATP binding cassette protein that cosediments with polysomes and is required for biogenesis of the small ribosomal subunit; Asn/Gln-rich rich region supports [NU+] prion formation and susceptibility to [PSI+] prion induction ribosomal small subunit biogenesis|poly(A)+ mRNA export from nucleus ATPase activity|ATP binding mitochondrion|polysome|cytoplasm
YOL096C YOL096C COQ3 hom Verified 0.518364569546987 0.302101964972737 no 1428 0.300740449743245 1069 NA FT KETONE METABOLISM|COFACTOR METABOLISM MITOCHONDRION O-methyltransferase, catalyzes two different O-methylation steps in ubiquinone (Coenzyme Q) biosynthesis; component of a mitochondrial ubiquinone-synthesizing complex; phosphoprotein ubiquinone biosynthetic process hexaprenyldihydroxybenzoate methyltransferase activity mitochondrion|mitochondrial inner membrane|extrinsic to membrane
YKL190W YKL190W CNB1 hom Verified 0.518218418401522 0.302152942748016 no 1429 0.30359543883001 1017 NA FF|FT SIGNALING|ION HOMEOSTASIS|CELL WALL ORG/BIOGENESIS|ION HOMEOSTASIS Calcineurin B; the regulatory subunit of calcineurin, a Ca++/calmodulin-regulated type 2B protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is encoded by CNA1 and/or CMP1; protein abundance increases in response to DNA replication stress adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion|fungal-type cell wall organization|cellular ion homeostasis calcium-dependent protein serine/threonine phosphatase activity|calcium ion binding calcineurin complex
YJL217W YJL217W REE1 hom Verified 0.516950507246042 0.302595354336994 no 1430 0.306054361159927 1028 NA Cytoplasmic protein involved in the regulation of enolase (ENO1); mRNA expression is induced by calcium shortage, copper deficiency (via Mac1p) and the presence of galactose (via Gal4p); mRNA expression is also regulated by the cell cycle biological_process molecular_function cytoplasm
YJL108C YJL108C PRM10 hom Verified 0.51683842498837 0.302634477103733 no 1431 0.31752496810031 1073 NA Pheromone-regulated protein, proposed to be involved in mating; predicted to have 5 transmembrane segments; induced by treatment with 8-methoxypsoralen and UVA irradiation biological_process molecular_function integral to membrane
YBR010W YBR010W HHT1 hom Verified 0.515997844729821 0.302927957263297 no 1432 0.315305780006418 1071 NA FT CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME Histone H3, core histone protein required for chromatin assembly, part of heterochromatin-mediated telomeric and HM silencing; one of two identical histone H3 proteins (see HHT2); regulated by acetylation, methylation, and phosphorylation chromatin assembly or disassembly|global genome nucleotide-excision repair|rRNA transcription|sexual sporulation resulting in formation of a cellular spore|mitotic cell cycle spindle assembly checkpoint DNA binding replication fork protection complex|nucleus|nuclear nucleosome
YNL243W YNL243W SLA2 hom Verified 0.515440905080393 0.303122477286578 no 1433 0.305705527316817 1000 NA FT VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS|CELL DIVISION|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON Adaptor protein that links actin to clathrin and endocytosis; involved in membrane cytoskeleton assembly and cell polarization; present in the actin cortical patch of the emerging bud tip; dimer in vivo bipolar cellular bud site selection|fungal-type cell wall organization|actin filament organization|endocytosis|exocytosis protein binding, bridging incipient cellular bud site|mating projection tip|actin cortical patch
YHR159W_p YHR159W TDA11 hom Uncharacterized 0.514262101500534 0.303534377317597 no 1434 0.321599772575223 1084 NA Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; potential Cdc28p substrate; null mutant is sensitive to expression of the top1-T722A allele biological_process molecular_function cytoplasm
YOR328W YOR328W PDR10 hom Verified 0.513733902882081 0.303719022651199 no 1435 0.295402870102133 984 NA FT NUCLEOTIDE METABOLISM PLASMA MEMBRANE ATP-binding cassette (ABC) transporter, multidrug transporter involved in the pleiotropic drug resistance network; regulated by Pdr1p and Pdr3p drug transmembrane transport ATPase activity, coupled to transmembrane movement of substances integral to membrane|plasma membrane
YIL128W YIL128W MET18 hom Verified 0.511332230343313 0.304559220066283 no 1436 0.465141976240841 1561 NA FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM|RESPONSE TO DNA DAMAGE NUCLEUS Component of cytosolic iron-sulfur protein assembly (CIA) machinery; acts at a late step of Fe-S cluster assembly; forms the CIA targeting complex with Cia1p and Cia2p that directs Fe-S cluster incorporation into a subset of proteins involved in methionine biosynthesis, DNA replication and repair, transcription, and telomere maintenance; ortholog of human MMS19 methionine metabolic process|nucleotide-excision repair|transcription from RNA polymerase II promoter molecular_function cytoplasm
YEL051W YEL051W VMA8 hom Verified 0.511162104608098 0.304618775790478 no 1437 0.330063967567708 1109 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS Subunit D of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; plays a role in the coupling of proton transport and ATP hydrolysis vacuolar acidification proton-transporting ATPase activity, rotational mechanism fungal-type vacuole membrane|vacuolar proton-transporting V-type ATPase, V1 domain|integral to membrane
YDR503C YDR503C LPP1 hom Verified 0.510757279961504 0.304760513121082 no 1438 0.289604506507929 968 NA FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Lipid phosphate phosphatase, catalyzes Mg(2+)-independent dephosphorylation of phosphatidic acid (PA), lysophosphatidic acid, and diacylglycerol pyrophosphate; involved in control of the cellular levels of phosphatidylinositol and PA phospholipid metabolic process phosphatidate phosphatase activity integral to membrane|membrane
YPR145W YPR145W ASN1 hom Verified 0.508759942551712 0.305460250226188 no 1439 0.316730414201892 1069 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Asparagine synthetase; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway; ASN1 has a paralog, ASN2, that arose from the whole genome duplication asparagine biosynthetic process asparagine synthase (glutamine-hydrolyzing) activity cytoplasm
YNR034W YNR034W SOL1 hom Verified 0.508367639613704 0.305597771309649 no 1440 0.259111745079274 890 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|RNA LOCALIZATION|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS NUCLEUS Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol3p and Sol4p; SOL1 has a paralog, SOL2, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress tRNA export from nucleus molecular_function|6-phosphogluconolactonase activity nucleus|cytoplasm
YDL240W YDL240W LRG1 hom Verified 0.507937771555562 0.305748492271884 no 1441 0.311397183752728 1059 NA FT SIGNALING|CELL WALL ORG/BIOGENESIS MITOCHONDRION|SITE OF POLARIZED GROWTH Putative GTPase-activating protein (GAP) involved in the Pkc1p-mediated signaling pathway that controls cell wall integrity; appears to specifically regulate 1,3-beta-glucan synthesis fungal-type cell wall biogenesis|small GTPase mediated signal transduction Rho GTPase activator activity mitochondrion|cellular bud neck|cytoplasm
YML058W-A YML058W-A HUG1 hom Verified 0.507474941668221 0.305910807153204 no 1442 0.298399940401683 1002 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE NUCLEUS Protein involved in the Mec1p-mediated checkpoint pathway; transcription is induced by DNA damage; protein abundance increases in response to DNA replication stress cell cycle arrest|cell cycle checkpoint|response to DNA damage stimulus molecular_function cytoplasm
YCR086W YCR086W CSM1 hom Verified 0.507416506646368 0.305931303082276 no 1443 0.287065802283401 995 NA FT PROTEIN LOCALIZATION|CELL CYCLE|CHROMOSOME SEGREGATION ENDOMEMBRANE SYSTEM|NUCLEUS|CHROMOSOME KINETOCHORE Nucleolar protein that forms a complex with Lrs4p and then Mam1p at kinetochores during meiosis I to mediate accurate homolog segregation; required for condensin recruitment to the replication fork barrier site and rDNA repeat segregation meiotic chromosome segregation|rDNA condensation|protein localization to nucleolar rDNA repeats|homologous chromosome segregation molecular_function nuclear envelope|nucleolus|monopolin complex
YOL060C YOL060C MAM3 hom Verified 0.507225121902104 0.305998435028618 no 1444 0.293907903729645 1007 NA FT ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS Protein required for normal mitochondrial morphology, has similarity to hemolysins cellular manganese ion homeostasis|mitochondrion organization molecular_function fungal-type vacuole membrane|integral to membrane
YMR041C YMR041C ARA2 hom Verified 0.507129899822903 0.30603183846539 no 1445 0.296271436115214 987 NA FT OXIDATION-REDUCTION PROCESS NAD-dependent arabinose dehydrogenase, involved in biosynthesis of dehydro-D-arabinono-1,4-lactone; similar to plant L-galactose dehydrogenase dehydro-D-arabinono-1,4-lactone biosynthetic process D-arabinose 1-dehydrogenase [NAD(P)+] activity cellular_component
YJL082W YJL082W IML2 hom Verified 0.506954444828196 0.306093391438361 no 1446 0.287414116457611 978 NA FT NUCLEUS|MITOCHONDRION Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; IML2 has a paralog, YKR018C, that arose from the whole genome duplication biological_process molecular_function mitochondrial outer membrane|mitochondrion|nucleus|cytoplasm
YBR067C YBR067C TIP1 hom Verified 0.506078291217631 0.30640084481577 no 1447 0.308905302848411 1043 NA FT CELL WALL ORG/BIOGENESIS Major cell wall mannoprotein with possible lipase activity; transcription is induced by heat- and cold-shock; member of the Srp1p/Tip1p family of serine-alanine-rich proteins fungal-type cell wall organization structural constituent of cell wall|lipase activity fungal-type cell wall
YGR124W YGR124W ASN2 hom Verified 0.505503233312437 0.30660271403322 no 1448 0.2994269132126 1022 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Asparagine synthetase; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway; ASN2 has a paralog, ASN1, that arose from the whole genome duplication asparagine biosynthetic process asparagine synthase (glutamine-hydrolyzing) activity cytoplasm
YLR434C_d YLR434C YLR434C hom Dubious 0.505465123945241 0.306616094078641 no 1449 0.323885384788459 1085 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF TSR2/YLR435W Unknown Unknown Unknown
YML038C YML038C YMD8 hom Verified 0.505198959605906 0.306709550492291 no 1450 0.308818374582733 1046 NA FT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Putative nucleotide sugar transporter, has similarity to Vrg4p UDP-glucose transport|nucleotide-sugar transport nucleotide-sugar transmembrane transporter activity COPI-coated vesicle|integral to membrane
YDR451C YDR451C YHP1 hom Verified 0.504325242982284 0.307016420781461 no 1451 0.361275843372156 1223 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE NUCLEUS|CHROMOSOME Homeobox transcriptional repressor; binds Mcm1p and early cell cycle box (ECB) elements of cell cycle regulated genes, thereby restricting ECB-mediated transcription to the M/G1 interval; YHP1 has a paralog, YOX1, that arose from the whole genome duplication negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription involved in G1 phase of mitotic cell cycle RNA polymerase II regulatory region sequence-specific DNA binding|RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription nuclear chromatin|nucleus
YMR226C YMR226C YMR226C hom Verified 0.504122465514598 0.307087660447985 no 1452 0.301830732604876 1042 NA FT OXIDATION-REDUCTION PROCESS NUCLEUS NADP(+)-dependent dehydrogenase; acts on serine, L-allo-threonine, and other 3-hydroxy acids; green fluorescent protein fusion protein localizes to the cytoplasm and nucleus; may interact with ribosomes, based on co-purification experiments metabolic process oxidoreductase activity|oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor|carbonyl reductase (NADPH) activity integral to membrane|ribosome|nucleus|cytoplasm
YBR168W YBR168W PEX32 hom Verified 0.503996495501353 0.30713191983013 no 1453 0.317889041573251 1092 NA FT PEROXISOME ORGANIZATION Peroxisomal integral membrane protein, involved in negative regulation of peroxisome size; partially functionally redundant with Pex31p; genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p peroxisome organization molecular_function integral to membrane|integral to peroxisomal membrane
YAR003W YAR003W SWD1 hom Verified 0.503643230486286 0.307256053970974 no 1454 0.340448694198483 1148 NA FT CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS|CHROMOSOME Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member with similarity to mammalian Rbbp7 histone H3-K4 methylation|telomere maintenance|regulation of transcription, DNA-dependent|chromatin silencing at telomere histone methyltransferase activity (H3-K4 specific) Set1C/COMPASS complex
YNL069C YNL069C RPL16B hom Verified 0.50243329707747 0.307681380967578 no 1455 0.32794689837494 1118 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L16B; N-terminally acetylated, binds 5.8 S rRNA; transcriptionally regulated by Rap1p; homologous to mammalian ribosomal protein L13A and bacterial L13; RPL16B has a paralog, RPL16A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome|RNA binding cytosolic large ribosomal subunit
YEL072W YEL072W RMD6 hom Verified 0.50040890726876 0.308393591374587 no 1456 0.303263015617033 1050 NA FT CELL CYCLE Protein required for sporulation biological_process molecular_function cellular_component
YPR003C_p YPR003C YPR003C hom Uncharacterized 0.500101705000591 0.308501732832199 no 1457 0.304517542716409 1038 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Putative sulfate permease; physically interacts with Hsp82p; green fluorescent protein (GFP)-fusion protein localizes to the ER; YPR003C is not an essential gene biological_process molecular_function integral to membrane|endoplasmic reticulum
YGR173W YGR173W RBG2 hom Verified 0.499823082559292 0.308599827977208 no 1458 0.303885380252899 999 NA FT TRANSLATION Protein with a role in translation; forms a complex with Gir2p; has similarity to mammalian developmentally regulated GTP-binding protein cytoplasmic translation GTP binding cytoplasm
YDR069C YDR069C DOA4 hom Verified 0.498329103283221 0.309126049051545 no 1459 0.330573811991559 1121 NA FT VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|PROTEOLYSIS MITOCHONDRION Ubiquitin isopeptidase, required for recycling ubiquitin from proteasome-bound ubiquitinated intermediates, acts at the late endosome/prevacuolar compartment to recover ubiquitin from ubiquitinated membrane proteins en route to the vacuole protein deubiquitination|endocytosis|regulation of DNA replication|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|free ubiquitin chain depolymerization|ubiquitin homeostasis|ubiquitin-dependent protein catabolic process endopeptidase activity|ubiquitin-specific protease activity|ubiquitin thiolesterase activity endosome|proteasome complex|mitochondrion
YDR329C YDR329C PEX3 hom Verified 0.497983940517516 0.30924768074753 no 1460 0.315455064211782 1052 NA FT PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION ENDOPLASMIC RETICULUM Peroxisomal membrane protein (PMP) required for proper localization and stability of PMPs; anchors peroxisome retention factor Inp1p at the peroxisomal membrane; interacts with Pex19p protein import into peroxisome membrane|peroxisome inheritance|ER-dependent peroxisome organization protein binding peroxisomal membrane|endoplasmic reticulum
YMR178W YMR178W YMR178W hom Verified 0.496886488158782 0.309634550186036 no 1461 0.290385127511119 977 NA FT COFACTOR METABOLISM NUCLEUS Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus; YMR178W is not an essential gene; protein abundance increases in response to DNA replication stress biological_process molecular_function nucleus|cytoplasm
YDL175C YDL175C AIR2 hom Verified 0.496206967023312 0.309874198014314 no 1462 0.317200313630975 1075 NA FT RNA PROCESSING NUCLEUS RNA-binding subunit of the TRAMP nuclear RNA surveillance complex; involved in nuclear RNA processing and degradation; involved in TRAMP complex assembly as a bridge between Mtr4p and Trf4p; stimulates the poly(A) polymerase activity of Pap2p in vitro; has 5 zinc knuckle motifs; AIR2 has a paralog, AIR1, that arose from the whole genome duplication nuclear polyadenylation-dependent CUT catabolic process|nuclear mRNA surveillance of mRNA 3'-end processing|nuclear polyadenylation-dependent tRNA catabolic process|nuclear polyadenylation-dependent snoRNA catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|nuclear polyadenylation-dependent snRNA catabolic process|ncRNA polyadenylation|tRNA modification polynucleotide adenylyltransferase activity|RNA binding|protein binding, bridging nucleolus|TRAMP complex
YHR142W YHR142W CHS7 hom Verified 0.49602916467776 0.309936917201293 no 1463 0.468634529701287 1555 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Protein of unknown function; may be involved in chitin biosynthesis by regulation of Chs3p export from the ER; relocalizes from bud neck to ER upon DNA replication stress protein folding|ER to Golgi vesicle-mediated transport|fungal-type cell wall chitin biosynthetic process unfolded protein binding integral to membrane|endoplasmic reticulum membrane
YGL079W_p YGL079W KXD1 hom Uncharacterized 0.495400982049415 0.310158550824153 no 1464 0.300111185075217 1006 NA Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; null mutant is sensitive to drug inducing secretion of vacuolar cargo; GFP-fusion protein localizes to the endosome biological_process molecular_function endosome
YMR073C YMR073C IRC21 hom Verified 0.494222934985407 0.310574371999906 no 1465 0.367306398567607 1212 NA FF Putative protein of unknown function; may be involved in resistance to carboplatin and cisplatin; null mutant displays increase in spontaneous Rad52p foci; contains a lipid-binding domain and binds cardiolipin in a large-scale study response to drug molecular_function cytoplasm
YOR158W YOR158W PET123 hom Verified 0.492297026370833 0.311254690988135 no 1466 0.322156602366751 1079 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the small subunit; PET123 exhibits genetic interactions with PET122, which encodes a COX3 mRNA-specific translational activator mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial small ribosomal subunit
YPL223C YPL223C GRE1 hom Verified 0.491622472819775 0.311493126842813 no 1467 0.328124590910635 1066 NA Hydrophilin essential in dessication-rehydration process; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway biological_process molecular_function cytoplasm
YAR042W YAR042W SWH1 hom Verified 0.490514421612173 0.311884963632611 no 1468 0.303496544571676 1040 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|GOLGI APPARATUS Protein similar to mammalian oxysterol-binding protein; contains ankyrin repeats; localizes to the Golgi and the nucleus-vacuole junction endocytosis|maintenance of cell polarity|exocytosis|sterol transport lipid binding|oxysterol binding|1-phosphatidylinositol binding|sterol transporter activity nuclear envelope|endoplasmic reticulum|Golgi trans cisterna|early endosome
YPR072W YPR072W NOT5 hom Verified 0.490195728617462 0.311997701532447 no 1469 0.315211979090357 1045 NA FT TRANSCRIPTION FROM RNA POL II|RNA PROCESSING NUCLEUS Subunit of the CCR4-NOT complex, which is a global transcriptional regulator with roles in transcription initiation and elongation and in mRNA degradation deadenylation-independent decapping of nuclear-transcribed mRNA|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|nuclear-transcribed mRNA poly(A) tail shortening|transcription elongation from RNA polymerase II promoter|protein ubiquitination ubiquitin-protein ligase activity CCR4-NOT core complex|cytoplasm
YMR191W YMR191W SPG5 hom Verified 0.489143308416256 0.31237012108842 no 1470 0.320911740240653 1067 NA Protein required for proteasome assembly during quiescence; binds to base of the proteasome regulartory particle; required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources biological_process molecular_function cellular_component
YPL273W YPL273W SAM4 hom Verified 0.488876804050939 0.312464459333032 no 1471 0.301393373525327 1049 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM NUCLEUS S-adenosylmethionine-homocysteine methyltransferase, functions along with Mht1p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio homocysteine metabolic process|L-methionine biosynthetic process from S-adenosylmethionine|S-adenosylhomocysteine metabolic process homocysteine S-methyltransferase activity nucleus|cytoplasm
YPL141C YPL141C FRK1 hom Verified 0.488475018033255 0.312606708332767 no 1472 0.312897912769054 1081 NA FT PROTEIN PHOSPHORYLATION Protein kinase of unknown cellular role; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; interacts with rRNA transcription and ribosome biogenesis factors and the long chain fatty acyl-CoA synthetase Faa3p; FRK1 has a paralog, KIN4, that arose from the whole genome duplication protein phosphorylation protein kinase activity cytoplasm
YOR246C YOR246C ENV9 hom Verified 0.488420848560082 0.312625888720776 no 1473 0.320428048170794 1096 NA FF|FT OXIDATION-REDUCTION PROCESS|VACUOLAR PROTEIN PROCESSING Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and defects in vacuolar morphology; has similarity to oxidoreductases, found in lipid particles; required for replication of Brome mosaic virus in S. cerevisiae, a model system for studying replication of positive-strand RNA viruses in their natural hosts vacuole organization|vacuolar protein processing oxidoreductase activity lipid particle
YKL107W_p YKL107W YKL107W hom Uncharacterized 0.488219001345413 0.312697363477827 no 1474 0.294650129746335 1024 NA FT OXIDATION-REDUCTION PROCESS Putative short-chain dehydrogenase/reductase; proposed to be a palmitoylated membrane protein biological_process molecular_function cellular_component
YNL138W YNL138W SRV2 hom Verified 0.488171316974721 0.312714249697677 no 1475 0.384627455812004 1262 NA FT SIGNALING|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH|CYTOSKELETON CAP (cyclase-associated protein) subunit of adenylyl cyclase complex; N-terminus binds adenylyl cyclase and facilitates activation by RAS; C-terminus binds ADP-actin monomers, facilitating regulation of actin dynamics and cell morphogenesis cytoskeleton organization|Ras protein signal transduction cytoskeletal protein binding|adenylate cyclase binding mating projection tip|actin cortical patch
YER050C YER050C RSM18 hom Verified 0.488156751475541 0.312719407781028 no 1476 0.330261606236619 1113 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial small ribosomal subunit
YOR113W YOR113W AZF1 hom Verified 0.488102247593331 0.312738709577922 no 1477 0.334571187234795 1133 NA FT TRANSCRIPTION FROM RNA POL II|CELL WALL ORG/BIOGENESIS NUCLEUS Zinc-finger transcription factor; in the presence of glucose, activates transcription of genes involved in growth and carbon metabolism; in nonfermentable carbon sources, activates transcription of genes involved in maintenance of cell wall integrity regulation of fungal-type cell wall organization|regulation of transcription from RNA polymerase II promoter|cellular response to carbohydrate stimulus RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus
YDR078C YDR078C SHU2 hom Verified 0.486548141990993 0.313289290504589 no 1478 0.316413008150273 1081 NA FT RESPONSE TO DNA DAMAGE NUCLEUS Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function recombinational repair|maintenance of rDNA|error-free translesion synthesis molecular_function Shu complex
YDL156W YDL156W CMR1 hom Verified 0.48449336690786 0.314017885345108 no 1479 0.326458506458783 1130 NA FT NUCLEUS|CHROMOSOME DNA-binding protein with preference for UV-damaged DNA; protein sequence contains three WD domains (WD-40 repeat); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; potential regulatory target of Mbp1p, which binds to the promoter region; co-localizes with Hos2p in nuclear foci in response to DNA damage by MMS biological_process DNA binding nuclear chromatin|nucleus|cytoplasm
YEL020C_p YEL020C YEL020C hom Uncharacterized 0.484073252733467 0.314166941455849 no 1480 0.320040887363809 1075 NA Protein of unknown function with low sequence identity to Pdc1p; mRNA identified as translated by ribosome profiling data biological_process molecular_function cytoplasm
YMR169C YMR169C ALD3 hom Verified 0.483603321763903 0.314333708438784 no 1481 0.313222731162262 1064 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS Cytoplasmic aldehyde dehydrogenase, involved in beta-alanine synthesis; uses NAD+ as the preferred coenzyme; very similar to Ald2p; expression is induced by stress and repressed by glucose beta-alanine biosynthetic process|polyamine catabolic process aldehyde dehydrogenase (NAD) activity cytoplasm
YGR163W YGR163W GTR2 hom Verified 0.48300365518942 0.314546570448888 no 1482 0.348136876794466 1167 NA FF|FT PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|MEMBRANE ORGANIZATION NUCLEUS|CHROMOSOME Putative GTP binding protein that negatively regulates Ran/Tc4 GTPase cycle; activates transcription; subunit of EGO and GSE complexes; required for sorting of Gap1p; localizes to cytoplasm and to chromatin; homolog of human RagC and RagD microautophagy|positive regulation of transcription from RNA polymerase II promoter GTP binding nuclear chromatin|fungal-type vacuole membrane|integral to membrane|EGO complex|nucleus|late endosome membrane|cytoplasm
YDR105C YDR105C TMS1 hom Verified 0.482678398366666 0.314662051773933 no 1483 0.322414834089085 1099 NA Vacuolar membrane protein of unknown function that is conserved in mammals; predicted to contain eleven transmembrane helices; interacts with Pdr5p, a protein involved in multidrug resistance biological_process molecular_function fungal-type vacuole membrane|integral to membrane|membrane
YAL009W YAL009W SPO7 hom Verified 0.481251327477753 0.315168942591398 no 1484 0.338949293715547 1132 NA FF|FT CELL CYCLE|LIPID METABOLISM|MEMBRANE ORGANIZATION ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM Putative regulatory subunit of Nem1p-Spo7p phosphatase holoenzyme, regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology, premeiotic replication, and sporulation negative regulation of phospholipid biosynthetic process|nuclear envelope organization phosphoprotein phosphatase activity Nem1-Spo7 phosphatase complex|integral to membrane
YMR269W YMR269W TMA23 hom Verified 0.479906189504992 0.315647049949595 no 1485 0.315760219206109 1065 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS NUCLEUS Nucleolar protein implicated in ribosome biogenesis; deletion extends chronological lifespan ribosomal small subunit biogenesis molecular_function ribosome|nucleolus
YLR054C YLR054C OSW2 hom Verified 0.479880322549326 0.315656246964911 no 1486 0.320983587835972 1104 NA FT CELL WALL ORG/BIOGENESIS Protein of unknown function proposed to be involved in the assembly of the spore wall ascospore wall assembly molecular_function integral to membrane|prospore membrane|cytoplasm
YCR023C YCR023C YCR023C hom Verified 0.47966423287313 0.315733082269921 no 1487 0.309732516550754 1044 NA Vacuolar membrane protein of unknown function; member of the multidrug resistance family; YCR023C is not an essential gene biological_process molecular_function fungal-type vacuole membrane|integral to membrane
YBR119W YBR119W MUD1 hom Verified 0.479068886314639 0.315944811659157 no 1488 0.339457703495599 1155 NA FT RNA PROCESSING NUCLEUS U1 snRNP A protein, homolog of human U1-A; involved in nuclear mRNA splicing mRNA splicing, via spliceosome U1 snRNA binding|RNA binding U1 snRNP|U2-type prespliceosome
YGL064C YGL064C MRH4 hom Verified 0.478125520980175 0.316280434295066 no 1489 0.327537434731543 1123 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS MITOCHONDRION Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function RNA metabolic process RNA helicase activity mitochondrion
YJR100C YJR100C AIM25 hom Verified 0.476910433302344 0.316712951119505 no 1490 0.300247127440147 1008 NA FT MITOCHONDRION Putative protein of unknown function; non-tagged protein is detected in purified mitochondria in high-throughput studies; similar to murine NOR1; null mutant is viable and displays elevated frequency of mitochondrial genome loss biological_process molecular_function mitochondrion
YKL170W YKL170W MRPL38 hom Verified 0.476424570061102 0.316885966880315 no 1491 0.328125365042079 1127 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL34 and YmL38) on two-dimensional SDS gels; protein abundance increases in response to DNA replication stress mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YIL050W YIL050W PCL7 hom Verified 0.475973751702478 0.317046538993615 no 1492 0.260482568358837 896 NA FT CELL CYCLE|OXIDATION-REDUCTION PROCESS|CELL DIVISION|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION|GEN. OF PRECURSOR METABOLITES AND ENERGY NUCLEUS Pho85p cyclin of the Pho80p subfamily, forms a functional kinase complex with Pho85p which phosphorylates Mmr1p and is regulated by Pho81p; involved in glycogen metabolism, expression is cell-cycle regulated regulation of glycogen catabolic process|regulation of cyclin-dependent protein kinase activity|regulation of protein stability|regulation of glycogen biosynthetic process cyclin-dependent protein kinase regulator activity cyclin-dependent protein kinase holoenzyme complex|nucleus
YHR179W YHR179W OYE2 hom Verified 0.473783558395259 0.317827130153987 no 1493 0.328641915607461 1102 NA FT OXIDATION-REDUCTION PROCESS NUCLEUS|MITOCHONDRION Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN); responsible for geraniol reduction into citronellol during fermentation; homologous to Oye3p with different ligand binding and catalytic properties; may be involved in sterol metabolism, oxidative stress response, and programmed cell death; protein abundance increases in response to DNA replication stress apoptotic process NADPH dehydrogenase activity mitochondrion|nucleus|cytoplasm
YGR017W_p YGR017W YGR017W hom Uncharacterized 0.47347299914721 0.31793788002991 no 1494 0.29161079070663 960 NA FT OXIDATION-REDUCTION PROCESS NUCLEUS Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm biological_process molecular_function nucleus|cytoplasm
YGL107C YGL107C RMD9 hom Verified 0.472415750543738 0.318315032069896 no 1495 0.328668193257883 1099 NA FT TRANSLATION|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Mitochondrial protein required for respiratory growth; mutant phenotype and genetic interactions suggest a role in delivering mt mRNAs to ribosomes; located on matrix face of the inner membrane and loosely associated with mitoribosomes translational initiation|regulation of mRNA stability|aerobic respiration molecular_function extrinsic to mitochondrial inner membrane|mitochondrion
YGL126W YGL126W SCS3 hom Verified 0.47110048795737 0.31878448834303 no 1496 0.326152847302459 1102 NA FT LIPID METABOLISM ENDOPLASMIC RETICULUM Protein required for inositol prototrophy; required for normal ER membrane biosynthesis; ortholog of the FIT family of proteins involved in triglyceride droplet biosynthesis and homologous to human FIT2; disputed role in the synthesis of inositol phospholipids from inositol phospholipid metabolic process molecular_function integral to membrane|endoplasmic reticulum
YGR231C YGR231C PHB2 hom Verified 0.468241397350253 0.319805985558012 no 1497 0.328734307865038 1135 NA FT PROTEOLYSIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation mitochondrion inheritance|protein folding|negative regulation of proteolysis|replicative cell aging molecular_function mitochondrion|mitochondrial inner membrane
YIL132C YIL132C CSM2 hom Verified 0.466447445732212 0.320447628530455 no 1498 0.28975795266266 987 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION NUCLEUS Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function; structural analysis reveals a similar DNA-binding region in both Psy3p and Csm2p and that both regions work together to form a single DNA binding site; required for accurate chromosome segregation during meiosis meiotic chromosome segregation|recombinational repair|maintenance of rDNA|error-free translesion synthesis molecular_function nucleus|Shu complex|cytoplasm
YKL034W YKL034W TUL1 hom Verified 0.466288991746595 0.32050432863462 no 1499 0.319698585198181 1099 NA FT PROTEOLYSIS ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Subunit of the DSC ubiquitin ligase complex; golgi-localized RING-finger ubiquitin ligase (E3) involved in sorting polar transmembrane domain containing membrane proteins to multivesicular bodies for delivery to the vacuole; proposed involvement in the quality control of misfolded TMD containing proteins; ortholog of fission yeast dsc1 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|protein ubiquitination ubiquitin-protein ligase activity integral to membrane|Golgi apparatus
YHL016C YHL016C DUR3 hom Verified 0.466174609621877 0.32054526096541 no 1500 0.299731815897912 996 NA FT PLASMA MEMBRANE Plasma membrane transporter for both urea and polyamines, expression is highly sensitive to nitrogen catabolite repression and induced by allophanate, the last intermediate of the allantoin degradative pathway urea transport|spermidine transport|putrescine transport|urea catabolic process urea transmembrane transporter activity|spermidine transmembrane transporter activity|putrescine transmembrane transporter activity integral to membrane|plasma membrane
YCL012C YCL012C YCL012C hom Verified 0.465144857099791 0.320913862320333 no 1501 0.304880440271145 1002 NA Putative protein of unknown function; orthologs are present in S. bayanus, S. paradoxus and Ashbya gossypii; YCL012C is not an essential gene biological_process molecular_function cellular_component
YHR067W YHR067W HTD2 hom Verified 0.46422430482965 0.321243524800205 no 1502 0.342978778498335 1157 NA FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS MITOCHONDRION Mitochondrial 3-hydroxyacyl-thioester dehydratase involved in fatty acid biosynthesis, required for respiratory growth and for normal mitochondrial morphology fatty acid biosynthetic process 3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity mitochondrion
YNL193W_p YNL193W YNL193W hom Uncharacterized 0.463203159085526 0.321609376029895 no 1503 0.29711097534826 1022 NA Putative protein of unknown function; exhibits a two-hybrid interaction with Yhr151cp in a large-scale analysis biological_process molecular_function cellular_component
YER020W YER020W GPA2 hom Verified 0.461871448194581 0.322086755070051 no 1504 0.298814153042267 1018 NA FT SIGNALING|NUCLEOTIDE METABOLISM MITOCHONDRION|PLASMA MEMBRANE Nucleotide binding alpha subunit of the heterotrimeric G protein that interacts with the receptor Gpr1p, has signaling role in response to nutrients; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery adenylate cyclase-activating G-protein coupled receptor signaling pathway|ascospore formation|replicative cell aging|signal transduction|glucose mediated signaling pathway|pseudohyphal growth|hexose mediated signaling|regulation of cell size GTPase activity mitochondrion|plasma membrane
YOR253W YOR253W NAT5 hom Verified 0.460647257599491 0.32252585037638 no 1505 0.324513515890324 1088 NA FT RIBOSOME Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing N-terminal protein amino acid acetylation peptide alpha-N-acetyltransferase activity NatA complex|cytosolic ribosome
YCL069W YCL069W VBA3 hom Verified 0.456587547454488 0.323983765680975 no 1506 0.325555578291067 1097 NA Permease of basic amino acids in the vacuolar membrane basic amino acid transport|transmembrane transport basic amino acid transmembrane transporter activity fungal-type vacuole membrane|integral to membrane
YIL127C_p YIL127C RRT14 hom Uncharacterized 0.455785435166825 0.324272139319637 no 1507 0.312558936718616 1085 NA FT NUCLEUS Putative protein of unknown function; identified in a screen for mutants with decreased levels of rDNA transcription; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis biological_process molecular_function nucleolus
YPR077C_d YPR077C YPR077C hom Dubious 0.455039902408208 0.324540266165511 no 1508 0.329324404663703 1122 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; expression increased by deletion of NAP1 Unknown Unknown Unknown
YKR039W YKR039W GAP1 hom Verified 0.454766970033831 0.324638447581194 no 1509 0.321767553564164 1056 NA FT KETONE METABOLISM|AMINO ACID METABOLISM PLASMA MEMBRANE General amino acid permease; Gap1p senses the presence of amino acid substrates to regulate localization to the plasma membrane when needed; essential for invasive growth amino acid transport|gamma-aminobutyric acid transport|ammonia assimilation cycle|polyamine transport amino acid transmembrane transporter activity|polyamine transmembrane transporter activity|L-proline transmembrane transporter activity endosome|fungal-type vacuole lumen|integral to membrane|plasma membrane|ER to Golgi transport vesicle|integral to plasma membrane|multivesicular body
YGL139W YGL139W FLC3 hom Verified 0.45164495439941 0.325762389584768 no 1510 0.315409743500403 1050 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION Putative FAD transporter, similar to Flc1p and Flc2p; localized to the ER FAD transport|transmembrane transport FAD transmembrane transporter activity mitochondrion|integral to membrane|endoplasmic reticulum
YPR023C YPR023C EAF3 hom Verified 0.451584772370519 0.325784071039155 no 1511 0.30405061867262 1052 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME HISTONE ACETYLTRANSFERASE Esa1p-associated factor, nonessential component of the NuA4 acetyltransferase complex, homologous to Drosophila dosage compensation protein MSL3; plays a role in regulating Ty1 transposition DNA repair|histone acetylation|regulation of DNA-dependent DNA replication initiation|negative regulation of antisense RNA transcription|regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|histone deacetylation histone acetyltransferase activity Rpd3S complex|histone acetyltransferase complex|Rpd3L complex|NuA4 histone acetyltransferase complex
YPR188C YPR188C MLC2 hom Verified 0.451010612516683 0.325990950125944 no 1512 0.321916045616549 1087 NA FT CELL CYCLE|CELL DIVISION SITE OF POLARIZED GROWTH|CYTOSKELETON Regulatory light chain for the type II myosin, Myo1p; binds to an IQ motif of Myo1p, localization to the bud neck depends on Myo1p; involved in the disassembly of the Myo1p ring actomyosin contractile ring contraction myosin II binding cellular bud neck contractile ring
YJL146W YJL146W IDS2 hom Verified 0.450276723470301 0.326255460228472 no 1513 0.312882254374523 1047 NA FT CELL CYCLE NUCLEUS Protein involved in modulation of Ime2p activity during meiosis, appears to act indirectly to promote Ime2p-mediated late meiotic functions; found in growing cells and degraded during sporulation meiosis molecular_function nucleus|cytoplasm
YEL050C YEL050C RML2 hom Verified 0.449942078317245 0.326376102888402 no 1514 0.355593497783199 1175 NA FF|FT KETONE METABOLISM|LIPID METABOLISM|TRANSLATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L2 ribosomal protein; fat21 mutant allele causes inability to utilize oleate and may interfere with activity of the Adr1p transcription factor cytoplasmic translation|fatty acid metabolic process structural constituent of ribosome mitochondrial large ribosomal subunit
YMR292W YMR292W GOT1 hom Verified 0.449940745979965 0.326376583244577 no 1515 0.308927615592971 1057 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS Homodimeric protein that is packaged into COPII vesicles and cycles between the ER and Golgi; involved in secretory transport but not directly required for aspects of transport assayed in vitro; may influence membrane composition ER to Golgi vesicle-mediated transport|Golgi to endosome transport molecular_function integral to membrane|endoplasmic reticulum|Golgi apparatus|ER to Golgi transport vesicle|Golgi membrane
YBR111W-A YBR111W-A SUS1 hom Verified 0.449526402991634 0.326525982968104 no 1516 0.391754565856475 1303 NA FT PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RNA LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS NUCLEAR PORE|HISTONE ACETYLTRANSFERASE Component of both the SAGA histone acetylase and TREX-2 complexes; interacts with RNA polymerase II; involved in mRNA export coupled transcription activation and elongation; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP poly(A)+ mRNA export from nucleus|regulation of protein localization|nuclear retention of pre-mRNA at the site of transcription|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|histone deubiquitination|histone H3-K4 methylation|transcription elongation from RNA polymerase II promoter|histone H3-K79 methylation|positive regulation of transcription from RNA polymerase II promoter enzyme activator activity DUBm complex|nucleoplasm|transcription export complex 2|SAGA complex|nuclear pore
YBR147W YBR147W RTC2 hom Verified 0.448113390790139 0.327035682178534 no 1517 0.31145500539724 1056 NA FT MITOCHONDRION Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; positive regulation by Lys14p suggests that lysine may be the primary substrate; member of the PQ-loop family, with seven transmembrane domains; similar to mammalian PQLC2 vacuolar transporter biological_process molecular_function mitochondrion|integral to membrane
YJR063W YJR063W RPA12 hom Verified 0.44716360708399 0.32737846792455 no 1518 0.355500917261539 1214 NA FF|FT NUCLEUS RNA polymerase I subunit A12.2; contains two zinc binding domains, and the N terminal domain is responsible for anchoring to the RNA pol I complex termination of RNA polymerase I transcription|transcription of nuclear large rRNA transcript from RNA polymerase I promoter molecular_function DNA-directed RNA polymerase I complex
YOR099W YOR099W KTR1 hom Verified 0.447128748888178 0.32739105134233 no 1519 0.31537659022437 1078 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Alpha-1,2-mannosyltransferase; involved in O- and N-linked protein glycosylation; type II membrane protein; member of the KRE2/MNT1 mannosyltransferase family; relocalizes from vacuole to cytoplasm upon DNA replication stress N-glycan processing|cell wall mannoprotein biosynthetic process|protein O-linked glycosylation alpha-1,2-mannosyltransferase activity Golgi apparatus
YDR461W YDR461W MFA1 hom Verified 0.446937259769428 0.327460180264463 no 1520 0.332336479352605 1124 NA FT SIGNALING PLASMA MEMBRANE Mating pheromone a-factor, made by a cells; interacts with alpha cells to induce cell cycle arrest and other responses leading to mating; biogenesis involves C-terminal modification, N-terminal proteolysis, and export; also encoded by MFA2 pheromone-dependent signal transduction involved in conjugation with cellular fusion mating pheromone activity extracellular region
YCR003W YCR003W MRPL32 hom Verified 0.446659589474732 0.327560431708219 no 1521 0.341785178163421 1144 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial inner membrane|mitochondrial large ribosomal subunit
YLR056W YLR056W ERG3 hom Verified 0.446595700301884 0.327583500328119 no 1522 0.362145993678924 1246 NA FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM C-5 sterol desaturase, glycoprotein that catalyzes the introduction of a C-5(6) double bond into episterol, a precursor in ergosterol biosynthesis; mutants are viable, but cannot grow on non-fermentable carbon sources; substrate of the HRD ubiquitin ligase ergosterol biosynthetic process C-5 sterol desaturase activity integral to membrane|endoplasmic reticulum|endoplasmic reticulum lumen
YJL023C YJL023C PET130 hom Verified 0.445671851418196 0.327917150240854 no 1523 0.322526382875551 1067 NA FT MITOCHONDRION Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process molecular_function mitochondrion
YAL018C_p YAL018C YAL018C hom Uncharacterized 0.444963143592184 0.32817319466513 no 1524 0.335743796095961 1076 NA Putative protein of unknown function biological_process molecular_function integral to membrane
YLR443W YLR443W ECM7 hom Verified 0.444604340943208 0.328302854930556 no 1525 0.328331675008525 1148 NA FT ION HOMEOSTASIS|CELL WALL ORG/BIOGENESIS|ION HOMEOSTASIS Non-essential putative integral membrane protein with a role in calcium uptake; mutant has cell wall defects and Ca+ uptake deficiencies; transcription is induced under conditions of zinc deficiency fungal-type cell wall organization|calcium ion transport molecular_function integral to membrane
YDR533C YDR533C HSP31 hom Verified 0.444037062723764 0.328507894069629 no 1526 0.342362218924342 1161 NA FT PROTEOLYSIS Possible chaperone and cysteine protease; has similarity to E. coli Hsp31; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease; exists as a dimer and contains a putative metal-binding site; protein abundance increases in response to DNA replication stress biological_process unfolded protein binding|cysteine-type peptidase activity cellular_component
YPL130W YPL130W SPO19 hom Verified 0.443533917946112 0.328689795806619 no 1527 0.303217593967984 1024 NA FT CELL CYCLE|MEMBRANE ORGANIZATION Meiosis-specific prospore protein; required to produce bending force necessary for proper assembly of the prospore membrane during sporulation; identified as a weak high-copy suppressor of the spo1-1 ts mutation meiosis|spore membrane bending pathway molecular_function fungal-type cell wall|prospore membrane
YGL070C YGL070C RPB9 hom Verified 0.443098320029101 0.328847310143026 no 1528 0.358951464777923 1194 NA FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO DNA DAMAGE NUCLEUS RNA POL II, HOLOENZYME RNA polymerase II subunit B12.6; contacts DNA; mutations affect transcription start site selection and fidelity of transcription transcription initiation from RNA polymerase II promoter|maintenance of transcriptional fidelity during DNA-dependent transcription elongation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|response to DNA damage stimulus|transcription from RNA polymerase II promoter RNA-directed RNA polymerase activity DNA-directed RNA polymerase II, core complex
YML028W YML028W TSA1 hom Verified 0.442124641066967 0.329199507120902 no 1529 0.324187108331799 1055 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|TRANSLATION|OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS Thioredoxin peroxidase; acts as both a ribosome-associated and free cytoplasmic antioxidant; self-associates to form a high-molecular weight chaperone complex under oxidative stress; deletion results in mutator phenotype; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress protein folding|cellular response to oxidative stress|replicative cell aging|DNA protection|DNA damage checkpoint|cell redox homeostasis|response to hydroperoxide unfolded protein binding|ribosome binding|peroxiredoxin activity|thioredoxin peroxidase activity cytosol|polysome|cytoplasm
YIR034C YIR034C LYS1 hom Verified 0.441479086767655 0.32943309919847 no 1530 0.348480012425706 1181 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS Saccharopine dehydrogenase (NAD+, L-lysine-forming), catalyzes the conversion of saccharopine to L-lysine, which is the final step in the lysine biosynthesis pathway; also has mRNA binding activity lysine biosynthetic process|lysine biosynthetic process via aminoadipic acid saccharopine dehydrogenase (NAD+, L-lysine-forming) activity|mRNA binding cytoplasm
YGR064W_d YGR064W YGR064W hom Dubious 0.440818230912141 0.329672297071085 no 1531 0.40974360659854 1340 NA FF Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SPT4/YGR063C Unknown Unknown Unknown
YKL149C YKL149C DBR1 hom Verified 0.439813316609001 0.330036161004668 no 1532 0.312661709738066 1070 NA FT RNA PROCESSING NUCLEUS RNA lariat debranching enzyme, involved in intron turnover; required for efficient Ty1 transposition snoRNA metabolic process|pseudohyphal growth|RNA catabolic process|transposition, RNA-mediated RNA lariat debranching enzyme activity nucleus
YDR195W YDR195W REF2 hom Verified 0.439472311491965 0.330159670253681 no 1533 0.352720283010034 1171 NA FT TRANSCRIPTION FROM RNA POL II|RNA PROCESSING NUCLEUS RNA-binding protein involved in the cleavage step of mRNA 3'-end formation prior to polyadenylation, and in snoRNA maturation; part of holo-CPF subcomplex APT, which associates with 3'-ends of snoRNA- and mRNA-encoding genes mRNA 3'-end processing|termination of RNA polymerase II transcription, poly(A)-coupled|snoRNA 3'-end processing|Unknown chromatin binding|RNA binding mRNA cleavage and polyadenylation specificity factor complex|nucleus
YPL144W YPL144W POC4 hom Verified 0.438744237299658 0.330423434676286 no 1534 0.319520060291581 1104 NA FT PROTEIN COMPLEX ORG/BIOGENESIS Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions proteasome assembly|chaperone-mediated protein complex assembly molecular_function intracellular|cytoplasm
YFR031C-A YFR031C-A RPL2A hom Verified 0.437661119674093 0.330815979011008 no 1535 0.328499054197032 1111 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L2A; homologous to mammalian ribosomal protein L2 and bacterial L2; RPL2A has a paralog, RPL2B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YPR108W-A_p YPR108W-A YPR108W-A hom Uncharacterized 0.437633538915329 0.330825977282805 no 1536 0.338808619250276 1127 NA Putative protein of unknown function; identified by fungal homology and RT-PCR biological_process molecular_function cellular_component
YPR036W YPR036W VMA13 hom Verified 0.43723351803983 0.330971001994007 no 1537 0.366533561275438 1252 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS Subunit H of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; serves as an activator or a structural stabilizer of the V-ATPase vacuolar acidification proton-transporting ATPase activity, rotational mechanism vacuolar proton-transporting V-type ATPase, V1 domain|fungal-type vacuole membrane|integral to membrane
YMR040W YMR040W YET2 hom Verified 0.436841302537524 0.331113221552794 no 1538 0.342277166394472 1138 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Protein of unknown function that may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein biological_process molecular_function ribosome|integral to membrane
YBR094W YBR094W PBY1 hom Verified 0.436712423313739 0.331159959208338 no 1539 0.318623804590422 1085 NA Putative tubulin tyrosine ligase associated with P-bodies; forms cytoplasmic foci upon DNA replication stress nuclear-transcribed mRNA catabolic process|biological_process molecular_function cytoplasmic mRNA processing body|cytoplasm
YOL109W YOL109W ZEO1 hom Verified 0.435409788097264 0.33163250343637 no 1540 0.337508981746578 1109 NA FT CELL WALL ORG/BIOGENESIS MITOCHONDRION|PLASMA MEMBRANE Peripheral membrane protein of the plasma membrane that interacts with Mid2p; regulates the cell integrity pathway mediated by Pkc1p and Slt2p; the authentic protein is detected in a phosphorylated state in highly purified mitochondria fungal-type cell wall organization|response to stress molecular_function mitochondrial outer membrane|mitochondrion|extrinsic to plasma membrane|plasma membrane
YNL319W_d YNL319W YNL319W hom Dubious 0.435272008528232 0.331682500071186 no 1541 0.34230973846073 1147 NA Dubious open reading frame unlikely to encode a protein; partially overlaps the verified gene HXT14 Unknown Unknown Unknown
YBR180W YBR180W DTR1 hom Verified 0.433485468345757 0.332331060436661 no 1542 0.329509940681568 1092 NA FT CELL WALL ORG/BIOGENESIS Putative dityrosine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; required for spore wall synthesis; expressed during sporulation ascospore wall assembly|amine transport|transmembrane transport amine transmembrane transporter activity integral to membrane|prospore membrane
YKL197C YKL197C PEX1 hom Verified 0.432949036023492 0.332525897428682 no 1543 0.329388448720011 1113 NA FT PROTEIN LOCALIZATION|SIGNALING|PEROXISOME ORGANIZATION AAA-peroxin that heterodimerizes with AAA-peroxin Pex6p and participates in the recycling of peroxisomal signal receptor Pex5p from the peroxisomal membrane to the cystosol; induced by oleic acid and upregulated during anaerobiosis protein import into peroxisome matrix, receptor recycling ATPase activity|protein heterodimerization activity peroxisomal membrane|peroxisome
YGL258W YGL258W VEL1 hom Verified 0.432828601246298 0.332569646633627 no 1544 0.354637412429966 1207 NA Protein of unknown function; highly induced in zinc-depleted conditions and has increased expression in NAP1 deletion mutants; VEL1 has paralog YOR387C biological_process molecular_function cytosol
YEL038W YEL038W UTR4 hom Verified 0.432667126252979 0.332628307709233 no 1545 0.297885173876883 1012 NA FT KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS Protein with sequence similarity to 2,3-diketo-5-methylthiopentyl-1-phosphate enolase-phosphatases, involved in methionine salvage; found in both the cytoplasm and nucleus L-methionine salvage from methylthioadenosine acireductone synthase activity nucleus|cytoplasm
YJL038C YJL038C LOH1 hom Verified 0.432564047805737 0.332665756471735 no 1546 0.338529098288953 1145 NA Protein of unknown function with proposed roles in maintenance of genome integrity and also in spore wall assembly; induced during sporulation; repressed during vegetative growth by Sum1p and Hst1p; sequence similar to IRC1 chromosome organization molecular_function cellular_component
YMR020W YMR020W FMS1 hom Verified 0.432331227470724 0.332750347063085 no 1547 0.302673200588882 1017 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM Polyamine oxidase, converts spermine to spermidine, which is required for the essential hypusination modification of translation factor eIF-5A; also involved in pantothenic acid biosynthesis pantothenate biosynthetic process|polyamine catabolic process polyamine oxidase activity cytoplasm
YDR121W YDR121W DPB4 hom Verified 0.431249520235456 0.333143475279493 no 1548 0.336206732532375 1125 NA FT GENE SILENCING NUCLEUS|CHROMOSOME Subunit of DNA pol epsilon and of ISW2 chromatin accessibility complex; involved in both chromosomal DNA replication and inheritance of telomeric silencing; stabilizes the interaction of Pol epsilon with primer-template DNA, positively affecting the processivity of the polymerase and exonuclease activities of Pol epsilon; interacts with extranucleosomal DNA and acts as anchor point for ISW2 complex that retains its position on DNA during nucleosome mobilization DNA-dependent DNA replication|chromatin silencing at telomere double-stranded DNA binding|single-stranded DNA binding|DNA-directed DNA polymerase activity chromatin accessibility complex|epsilon DNA polymerase complex
YOR315W YOR315W SFG1 hom Verified 0.431242548804701 0.333146009523505 no 1549 0.328401064821754 1118 NA FT CELL CYCLE NUCLEUS Nuclear protein, putative transcription factor required for growth of superficial pseudohyphae (which do not invade the agar substrate) but not for invasive pseudohyphal growth; may act together with Phd1p; potential Cdc28p substrate mitotic cell cycle|pseudohyphal growth molecular_function nucleus|cytoplasm
YIL070C YIL070C MAM33 hom Verified 0.430200832864001 0.333524778105861 no 1550 0.335458219052589 1130 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Acidic protein of the mitochondrial matrix involved in oxidative phosphorylation; related to the human complement receptor gC1q-R aerobic respiration molecular_function mitochondrion|mitochondrial matrix
YNL093W YNL093W YPT53 hom Verified 0.429509695458757 0.333776169818395 no 1551 0.395911938024628 1309 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING|VACUOLAR TRANSPORT PLASMA MEMBRANE Rab family GTPase; similar to Ypt51p and Ypt52p and to mammalian rab5; required for vacuolar protein sorting and endocytosis; YPT53 has a paralog, VPS21, that arose from the whole genome duplication endocytosis|protein targeting to vacuole GTPase activity late endosome
YDR371W_p YDR371W CTS2 hom Uncharacterized 0.429233787656419 0.333876548332197 no 1552 0.323906270507114 1067 NA FT CARBOHYDRATE METABOLISM Putative chitinase, functionally complements A. gossypii cts2 mutant sporulation defect sporulation resulting in formation of a cellular spore molecular_function cytoplasm
YML075C YML075C HMG1 hom Verified 0.429195691700221 0.33389040902475 no 1553 0.333226268155189 1108 NA FT LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM HMG-CoA reductase; catalyzes the conversion of HMG-CoA to mevalonate, which is a rate-limiting step in sterol biosynthesis; one of two isozymes; localizes to the nuclear envelope; overproduction induces the formation of karmellae; forms foci at the nuclear periphery upon DNA replication stress ergosterol biosynthetic process|isopentenyl diphosphate biosynthetic process, mevalonate pathway hydroxymethylglutaryl-CoA reductase (NADPH) activity nuclear envelope|integral to membrane|endoplasmic reticulum membrane
YHL017W_p YHL017W YHL017W hom Uncharacterized 0.428349602637562 0.334198305337706 no 1554 0.319230647761134 1065 NA FT GOLGI APPARATUS Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein co-localizes with clathrin-coated vesicles; YHL017W has a paralog, PTM1, that arose from the whole genome duplication biological_process molecular_function integral to membrane|clathrin-coated vesicle
YLL006W YLL006W MMM1 hom Verified 0.426411394328239 0.334904050044536 no 1555 0.365068649274563 1221 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION ER integral membrane protein, component of the ERMES complex that links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth mitochondrion organization|mitochondrial genome maintenance|protein import into mitochondrial outer membrane|phospholipid transport molecular_function mitochondrial outer membrane|mitochondrion|integral to endoplasmic reticulum membrane|ERMES complex
YLR358C_p YLR358C YLR358C hom Uncharacterized 0.425017138616074 0.335412090506704 no 1556 0.297942700977917 1010 NA Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps ORF RSC2/YLR357W biological_process molecular_function cellular_component
YLR232W_d YLR232W YLR232W hom Dubious 0.424542341512948 0.335585166385964 no 1557 0.323406675122052 1076 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene BNA5 Unknown Unknown Unknown
YER156C_p YER156C YER156C hom Uncharacterized 0.423043398175184 0.336131798972821 no 1558 0.306685637554444 1037 NA FT NUCLEUS Putative protein of unknown function; interacts with Hsp82p and copurifies with Ipl1p; expression is copper responsive and downregulated in strains deleted for MAC1, a copper-responsive transcription factor; similarity to mammalian MYG1 biological_process molecular_function nucleus|cytoplasm
YGL254W YGL254W FZF1 hom Verified 0.420580367584355 0.337030766079417 no 1559 0.345829429468399 1134 NA FT TRANSCRIPTION FROM RNA POL II|ION HOMEOSTASIS|ION HOMEOSTASIS NUCLEUS Transcription factor involved in sulfite metabolism; sole identified regulatory target is SSU1; overexpression suppresses sulfite-sensitivity of many unrelated mutants due to hyperactivation of SSU1, contains five zinc fingers; protein abundance increases in response to DNA replication stress positive regulation of sulfite transport by positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus
YKR091W YKR091W SRL3 hom Verified 0.419536483568782 0.337412048573637 no 1560 0.344296784435477 1151 NA Cytoplasmic protein that, when overexpressed, suppresses the lethality of a rad53 null mutation; potential Cdc28p substrate nucleobase-containing compound metabolic process molecular_function cytoplasm
YDR315C YDR315C IPK1 hom Verified 0.419323541230398 0.33748984707084 no 1561 0.381389685703655 1267 NA FT NUCLEUS Inositol 1,3,4,5,6-pentakisphosphate 2-kinase, nuclear protein required for synthesis of 1,2,3,4,5,6-hexakisphosphate (phytate), which is integral to cell function; has 2 motifs conserved in other fungi; ipk1 gle1 double mutant is inviable nuclear-transcribed mRNA catabolic process, non-stop decay|inositol phosphate biosynthetic process inositol pentakisphosphate 2-kinase activity nucleus
YGR233C YGR233C PHO81 hom Verified 0.419223691965314 0.337526329398998 no 1562 0.349616549579008 1153 NA FT LIPID METABOLISM NUCLEUS Cyclin-dependent kinase (CDK) inhibitor; regulates Pho80p-Pho85p and Pcl7p-Pho85p cyclin-CDK complexes in response to phosphate levels; inhibitory activity for Pho80p-Pho85p requires myo-D-inositol heptakisphosphate (IP7) generated by Vip1p; relative distribution to the nucleus increases upon DNA replication stress phosphate-containing compound metabolic process cyclin-dependent protein kinase inhibitor activity nucleus|cytoplasm
YML101C YML101C CUE4 hom Verified 0.418239956280065 0.3378858424615 no 1563 0.275864855822154 918 NA FT ENDOPLASMIC RETICULUM Protein of unknown function; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination; CUE4 has a paralog, CUE1, that arose from the whole genome duplication biological_process molecular_function endoplasmic reticulum|cytoplasm
YPR096C YPR096C YPR096C hom Verified 0.415997338857242 0.338705975251072 no 1564 0.324532033578111 1089 NA Protein of unknown function that may interact with ribosomes, based on co-purification experiments biological_process molecular_function ribosome
YGR270W YGR270W YTA7 hom Verified 0.414890670621865 0.339110969859618 no 1565 0.37292837476443 1267 NA FT TRANSCRIPTION FROM RNA POL II|GENE SILENCING ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM Protein that localizes to chromatin and has a role in regulation of histone gene expression; has a bromodomain-like region that interacts with the N-terminal tail of histone H3, and an ATPase domain; potentially phosphorylated by Cdc28p negative regulation of transcription from RNA polymerase II promoter|negative regulation of chromatin silencing|positive regulation of transcription from RNA polymerase II promoter chromatin binding|histone binding extrinsic to endoplasmic reticulum membrane|nucleus
YLR297W YLR297W YLR297W hom Verified 0.414410981100723 0.339286574107017 no 1566 0.338680393930107 1141 NA Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; not an essential gene; induced by treatment with 8-methoxypsoralen and UVA irradiation; relocalizes from nucleus to vacuole upon DNA replication stress; YLR297W has a paralog, YOR186W, that arose from the whole genome duplication biological_process molecular_function fungal-type vacuole
YCR034W YCR034W FEN1 hom Verified 0.414272712948513 0.339337197653558 no 1567 0.457845469267021 1508 NA FF|FT VESICLE-MEDIATED TRANSPORT|KETONE METABOLISM|LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Fatty acid elongase, involved in sphingolipid biosynthesis; acts on fatty acids of up to 24 carbons in length; mutations have regulatory effects on 1,3-beta-glucan synthase, vacuolar ATPase, and the secretory pathway; FEN1 has a paralog, ELO1, that arose from the whole genome duplication fatty acid elongation|vesicle-mediated transport|sphingolipid biosynthetic process fatty acid elongase activity integral to membrane|endoplasmic reticulum|endoplasmic reticulum membrane
YDL231C YDL231C BRE4 hom Verified 0.41417820550035 0.339371800943026 no 1568 0.346347744923915 1151 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION Zinc finger protein containing five transmembrane domains; null mutant exhibits strongly fragmented vacuoles and sensitivity to brefeldin A, a drug which is known to affect intracellular transport endocytosis molecular_function integral to membrane
YIL168W YIL168W YIL168W hom pseudogene 0.413166998591978 0.339742132526498 no 1569 0.342186710091761 1131 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Open reading frame, unlikely to produce a functional protein in S288C; in closely related species and other S. cerevisiae strain backgrounds YIL168W and adjacent ORF, YIL167W, constitute a single ORF encoding L-serine dehydratase serine family amino acid metabolic process L-serine ammonia-lyase activity cellular_component
YNR060W YNR060W FRE4 hom Verified 0.412258938509225 0.340074820817296 no 1570 0.334435925451597 1132 NA FT ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|GEN. OF PRECURSOR METABOLITES AND ENERGY PLASMA MEMBRANE Ferric reductase, reduces a specific subset of siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels siderophore transport ferric-chelate reductase activity integral to membrane|plasma membrane
YPR117W_p YPR117W YPR117W hom Uncharacterized 0.411342054693815 0.340410868269465 no 1571 0.34071943079611 1144 NA Putative protein of unknown function biological_process molecular_function cellular_component
YBR176W YBR176W ECM31 hom Verified 0.409853117276453 0.340956849283882 no 1572 0.351646889250453 1152 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM MITOCHONDRION Ketopantoate hydroxymethyltransferase, required for pantothenic acid biosynthesis, converts 2-oxoisovalerate into 2-dehydropantoate pantothenate biosynthetic process 3-methyl-2-oxobutanoate hydroxymethyltransferase activity mitochondrion
YPR039W_d YPR039W YPR039W hom Dubious 0.409473252610262 0.341096195910677 no 1573 0.356957719717895 1207 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified non essential genes ERV2/YPR037C and TIP41/YPR040W Unknown Unknown Unknown
YGR254W YGR254W ENO1 hom Verified 0.407797825970537 0.341711054920675 no 1574 0.328103520523588 1097 NA FT MEMBRANE ORGANIZATION|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Enolase I, a phosphopyruvate hydratase; catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate during glycolysis and the reverse reaction during gluconeogenesis; expression is repressed in response to glucose; protein abundance increases in response to DNA replication stress regulation of vacuole fusion, non-autophagic|gluconeogenesis|glycolysis phosphopyruvate hydratase activity mitochondrion|phosphopyruvate hydratase complex|plasma membrane|fungal-type vacuole|cytoplasm
YKL068W-A_p YKL068W-A YKL068W-A hom Uncharacterized 0.407194633568861 0.341932521365071 no 1575 0.380716279546295 1281 NA Putative protein of unknown function; identified by homology to Ashbya gossypii biological_process molecular_function cellular_component
YCR037C YCR037C PHO87 hom Verified 0.405535370633528 0.342542012181513 no 1576 0.349163722100701 1174 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS Low-affinity inorganic phosphate (Pi) transporter; involved in activation of PHO pathway; expression is independent of Pi concentration and Pho4p activity; contains 12 membrane-spanning segments; PHO87 has a paralog, PHO90, that arose from the whole genome duplication phosphate ion transport|transmembrane transport inorganic phosphate transmembrane transporter activity integral to membrane|membrane
YPL200W YPL200W CSM4 hom Verified 0.405501646880547 0.342554404059558 no 1577 0.351077029881014 1158 NA FT CELL CYCLE|CHROMOSOME SEGREGATION ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|CHROMOSOME Protein required for accurate chromosome segregation during meiosis; involved in meiotic telomere clustering (bouquet formation) and telomere-led rapid prophase movements meiotic telomere clustering|meiotic chromosome segregation|synapsis|regulation of reciprocal meiotic recombination molecular_function nuclear chromosome, telomeric region|endoplasmic reticulum membrane
YPL061W YPL061W ALD6 hom Verified 0.404856737138212 0.342791410362656 no 1578 0.335581768189937 1134 NA FT KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM MITOCHONDRION Cytosolic aldehyde dehydrogenase, activated by Mg2+ and utilizes NADP+ as the preferred coenzyme; required for conversion of acetaldehyde to acetate; constitutively expressed; locates to the mitochondrial outer surface upon oxidative stress response to salt stress|NADPH regeneration|acetate biosynthetic process aldehyde dehydrogenase [NAD(P)+] activity cytosol|mitochondrion
YLR367W YLR367W RPS22B hom Verified 0.402445019627742 0.343678271733991 no 1579 0.33488446058467 1134 NA FT TRANSLATION RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22B has a paralog, RPS22A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic small ribosomal subunit
YMR058W YMR058W FET3 hom Verified 0.401924950469029 0.343869629898043 no 1580 0.358187936679417 1211 NA FT ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS PLASMA MEMBRANE Ferro-O2-oxidoreductase; required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity, belongs to class of integral membrane multicopper oxidases; protein abundance increases in response to DNA replication stress iron assimilation by reduction and transport|high-affinity iron ion transport|response to copper ion ferroxidase activity|iron ion transmembrane transporter activity integral to membrane|high affinity iron permease complex|plasma membrane
YOR154W_p YOR154W SLP1 hom Uncharacterized 0.401055159736839 0.344189756629496 no 1581 0.319129978506369 1090 NA Glycosylated integral ER membrane protein of unknown function; forms an ER-membrane associated protein complex with Emp65p; member of the SUN-like family of proteins; genetic interactions suggest a role in folding of ER membrane proteins; required for nuclear envelope localization of Mps3p protein folding in endoplasmic reticulum molecular_function cellular_component
YPR121W YPR121W THI22 hom Verified 0.400231056825234 0.344493170993051 no 1582 0.31003950802199 1049 NA Protein with similarity to hydroxymethylpyrimidine phosphate kinases; member of a gene family with THI20 and THI21; not required for thiamine biosynthesis thiamine biosynthetic process phosphomethylpyrimidine kinase activity|hydroxymethylpyrimidine kinase activity cellular_component
YER069W YER069W ARG5,6 hom Verified 0.396850608569706 0.345738814151048 no 1583 0.338509508152702 1115 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS MITOCHONDRION Acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase; N-acetyl-L-glutamate kinase (NAGK) catalyzes the 2nd and N-acetyl-gamma-glutamyl-phosphate reductase (NAGSA), the 3rd step in arginine biosynthesis; synthesized as a precursor which is processed in the mitochondrion to yield mature NAGK and NAGSA; enzymes form a metabolon complex with Arg2p; NAGK C-terminal domain stabilizes the enzymes, slows catalysis and is involved in feed-back inhibition by arginine ornithine biosynthetic process|arginine biosynthetic process|regulation of transcription, DNA-dependent N-acetyl-gamma-glutamyl-phosphate reductase activity|acetylglutamate kinase activity mitochondrion|mitochondrial matrix
YLR327C YLR327C TMA10 hom Verified 0.396660644747875 0.345808862632501 no 1584 0.348119795340253 1158 NA FT NUCLEUS|MITOCHONDRION Protein of unknown function that associates with ribosomes; putative homolog of the F1F0-ATPase synthase regulator Stf2p; protein abundance increases in response to DNA replication stress biological_process molecular_function ribosome|nucleus|cytoplasm
YGR130C YGR130C YGR130C hom Verified 0.396125306997952 0.346006294908074 no 1585 0.362622086562669 1212 NA Component of the eisosome with unknown function; GFP-fusion protein localizes to the cytoplasm; specifically phosphorylated in vitro by mammalian diphosphoinositol pentakisphosphate (IP7) biological_process molecular_function eisosome|membrane raft|cytoplasm
YMR153C-A_d YMR153C-A YMR153C-A hom Dubious 0.394381494532121 0.346649702106023 no 1586 0.306182683695212 1032 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NUP53 Unknown Unknown Unknown
YCR084C YCR084C TUP1 hom Verified 0.393843122781563 0.346848432382028 no 1587 0.34116017839415 1147 NA FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|LIPID METABOLISM|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|RESPONSE TO NUTRIENT LEVELS NUCLEUS General repressor of transcription, forms complex with Cyc8p, involved in the establishment of repressive chromatin structure through interactions with histones H3 and H4, appears to enhance expression of some genes nucleosome positioning|regulation of transcription from RNA polymerase II promoter in response to osmotic stress|histone exchange|negative regulation of mating-type specific transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter by glucose|negative regulation of dipeptide transport by negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter in response to hypoxia|negative regulation of transcription from RNA polymerase II promoter during mitosis|Unknown ubiquitin binding|histone deacetylase binding|histone binding|phosphatidylinositol-3,5-bisphosphate binding|RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription|mediator complex binding nucleus|transcriptional repressor complex
YMR206W_p YMR206W YMR206W hom Uncharacterized 0.392952099923668 0.347177430055712 no 1588 0.335113471196691 1112 NA Putative protein of unknown function; not an essential gene; YMR206W has a paralog, YNR014W, that arose from the whole genome duplication biological_process molecular_function cellular_component
YCL014W YCL014W BUD3 hom Verified 0.391587824178189 0.347681392886556 no 1589 0.347541277421745 1177 NA FT CELL CYCLE|SIGNALING|CELL DIVISION SITE OF POLARIZED GROWTH|CYTOSKELETON Protein involved in bud-site selection and required for axial budding pattern; localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding cellular bud site selection|axial cellular bud site selection|cytokinesis molecular_function cellular bud neck contractile ring|cellular bud neck
YGL101W_p YGL101W YGL101W hom Uncharacterized 0.391334495125991 0.347775002191471 no 1590 0.346635932771243 1144 NA FT NUCLEUS Putative protein of unknown function; non-essential gene with similarity to YBR242W; interacts with the DNA helicase Hpr5p biological_process molecular_function nucleus|cytoplasm
YER060W-A YER060W-A FCY22 hom Verified 0.390900022106274 0.347935568814453 no 1591 0.320437160922742 1051 NA Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function transmembrane transport nucleobase transmembrane transporter activity integral to membrane
YMR140W YMR140W SIP5 hom Verified 0.390001548628156 0.348267700893489 no 1592 0.33099184684992 1104 NA FT RESPONSE TO NUTRIENT LEVELS Protein of unknown function; interacts with both the Reg1p/Glc7p phosphatase and the Snf1p kinase; forms cytoplasmic foci upon DNA replication stress cellular response to glucose starvation molecular_function cytoplasm
YLR451W YLR451W LEU3 hom Verified 0.389831601085953 0.348330537248804 no 1593 0.347577295384278 1135 NA FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS Zinc-knuckle transcription factor, repressor and activator; regulates genes involved in branched chain amino acid biosynthesis and ammonia assimilation; acts as a repressor in leucine-replete conditions and as an activator in the presence of alpha-isopropylmalate, an intermediate in leucine biosynthesis that accumulates during leucine starvation negative regulation of transcription from RNA polymerase II promoter|Unknown|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus
YNR049C YNR049C MSO1 hom Verified 0.389805189866595 0.348340302899245 no 1594 0.346601599041513 1153 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION SITE OF POLARIZED GROWTH|PLASMA MEMBRANE Probable component of the secretory vesicle docking complex; acts at a late step in secretion; shows genetic and physical interactions with Sec1p; required for prospore membrane formation during sporulation; relocalizes from bud neck to nucleus upon DNA replication stress cellular membrane fusion|ascospore-type prospore membrane assembly|vesicle docking involved in exocytosis molecular_function SNARE complex|cellular bud membrane|plasma membrane|prospore membrane|cellular bud neck|cellular bud tip
YKR017C YKR017C HEL1 hom Verified 0.38837925279708 0.348867697737004 no 1595 0.35819752654715 1201 NA RING finger ubiquitin ligase (E3); involved in ubiquitylation and degradation of excess histones; interacts with Ubc4p and Rad53p; null mutant sensitive to hydroxyurea (HU) biological_process molecular_function cellular_component
YKL113C YKL113C RAD27 hom Verified 0.387688053167159 0.349123448931156 no 1596 0.368501330193598 1232 NA FT RESPONSE TO DNA DAMAGE NUCLEUS|MITOCHONDRION 5' to 3' exonuclease, 5' flap endonuclease, required for Okazaki fragment processing and maturation as well as for long-patch base-excision repair; member of the S. pombe RAD2/FEN1 family double-strand break repair via nonhomologous end joining|replicative cell aging|DNA replication, removal of RNA primer|base-excision repair, base-free sugar-phosphate removal|gene conversion at mating-type locus, DNA repair synthesis 5'-3' exonuclease activity|5'-flap endonuclease activity mitochondrion|nucleus
YNR007C YNR007C ATG3 hom Verified 0.386935244231714 0.349402074197584 no 1597 0.359128184571689 1211 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS E2-like enzyme involved in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; plays a role in formation of Atg8p-phosphatidylethanolamine conjugates, which are involved in membrane dynamics during autophagy and Cvt; interaction with Atg8p is regulated by its acetylation by Esa1p (catalytic subunit of NuA4 histone acetyltransferase complex) while attenuation of Atg3 acetylation is mediated by histone deacetylase Rpd3p C-terminal protein lipidation|piecemeal microautophagy of nucleus|mitochondrion degradation|CVT pathway|autophagic vacuole assembly Atg8 ligase activity cytosol|cytoplasm
YMR044W YMR044W IOC4 hom Verified 0.386287119130426 0.349642019522435 no 1598 0.364288263524418 1209 NA FT CHROMATIN ORGANIZATION NUCLEUS Member of a complex (Isw1b) with Isw1p and Ioc2p; interacts directly with H3K36me3 nucleosomes through its PWWP domain to recruit the Isw1b complex to open reading frames in a Set2p-dependent manner; Isw1b exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing chromatin remodeling nucleosome binding|ATPase activity|DNA binding ISW1 complex
YLR406C-A_p YLR406C-A YLR406C-A hom Uncharacterized 0.38601061400222 0.349744404024912 no 1599 0.350021376796543 1159 NA Putative protein of unknown function biological_process molecular_function cellular_component
YKL033W-A_p YKL033W-A YKL033W-A hom Uncharacterized 0.385844686822499 0.349805848898344 no 1600 0.395320039338079 1319 NA Putative protein of unknown function; similar to uncharacterized proteins from other fungi biological_process molecular_function cellular_component
YMR026C YMR026C PEX12 hom Verified 0.385315007558781 0.350002021954282 no 1601 0.366184542860622 1212 NA FT PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION C3HC4-type RING-finger peroxin and E3 ubiquitin ligase, required for peroxisome biogenesis and peroxisomal matrix protein import; forms translocation subcomplex with Pex2p and Pex10p; mutations in human homolog cause peroxisomal disorder protein import into peroxisome matrix ubiquitin-protein ligase activity|protein binding integral to peroxisomal membrane
YBR003W YBR003W COQ1 hom Verified 0.385133565324266 0.350069230467622 no 1602 0.37426622553315 1232 NA FT KETONE METABOLISM|LIPID METABOLISM|COFACTOR METABOLISM MITOCHONDRION Hexaprenyl pyrophosphate synthetase, catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis ubiquinone biosynthetic process trans-hexaprenyltranstransferase activity mitochondrion
YGL129C YGL129C RSM23 hom Verified 0.384431226318872 0.350329430035239 no 1603 0.345666201594111 1169 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the small subunit, has similarity to mammalian apoptosis mediator proteins; null mutation prevents induction of apoptosis by overproduction of metacaspase Mca1p mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial small ribosomal subunit
YNR073C_p YNR073C YNR073C hom Uncharacterized 0.383032757023104 0.35084773812528 no 1604 0.388269723520824 1304 NA Putative mannitol dehydrogenase; identical in amino acid sequence to Dsf1p biological_process mannitol dehydrogenase activity cellular_component
YGL168W YGL168W HUR1 hom Verified 0.382680118802614 0.35097847864542 no 1605 0.418738953996203 1374 NA FF|FT ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS Protein of unknown function; reported null mutant phenotype of hydroxyurea sensitivity may be due to effects on overlapping PMR1 gene DNA replication molecular_function cellular_component
YDR004W YDR004W RAD57 hom Verified 0.382015847227845 0.351224805055102 no 1606 0.360496287458071 1216 NA FF|FT CELL CYCLE|RESPONSE TO DNA DAMAGE NUCLEUS Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad55p DNA recombinase assembly|telomere maintenance via recombination|heteroduplex formation|meiotic DNA recombinase assembly|double-strand break repair via single-strand annealing DNA-dependent ATPase activity|protein heterodimerization activity nucleus|Rhp55-Rhp57 complex
YOL143C YOL143C RIB4 hom Verified 0.381752747222182 0.351322385573378 no 1607 0.375712558485952 1244 NA FT NUCLEUS Lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, also known as DMRL synthase); catalyzes synthesis of immediate precursor to riboflavin riboflavin biosynthetic process 6,7-dimethyl-8-ribityllumazine synthase activity nucleus|cytoplasm
YLR405W YLR405W DUS4 hom Verified 0.380571019400531 0.351760794513718 no 1608 0.342993155994666 1136 NA FT RNA PROCESSING|OXIDATION-REDUCTION PROCESS Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus3p tRNA modification tRNA dihydrouridine synthase activity cellular_component
YLR356W YLR356W ATG33 hom Verified 0.379658482376267 0.352099471389608 no 1609 0.345853583651983 1158 NA FT MITOCHONDRION Mitochondrial mitophagy-specific protein; required primarily for mitophagy induced at the post-log phase; not required for other types of selective autophagy or macroautophagy; conserved within fungi, but not in higher eukaryotes mitochondrion degradation molecular_function mitochondrion|integral to membrane
YMR012W YMR012W CLU1 hom Verified 0.379020398756389 0.352336357999431 no 1610 0.339793996303954 1113 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION eIF3 component of unknown function; deletion causes defects in mitochondrial organization but not in growth or translation initiation, can rescue cytokinesis and mitochondrial organization defects of the Dictyostelium cluA- mutant translational initiation|mitochondrion organization molecular_function eukaryotic translation initiation factor 3 complex|cytoplasm
YBL067C YBL067C UBP13 hom Verified 0.378828001593833 0.352407796109487 no 1611 0.363002804188138 1204 NA FT PROTEOLYSIS Putative ubiquitin-specific protease that cleaves Ub-protein fusions; UBP13 has a paralog, UBP9, that arose from the whole genome duplication biological_process ubiquitin-specific protease activity cellular_component
YHR134W YHR134W WSS1 hom Verified 0.377785827937365 0.352794851276172 no 1612 0.296318875204753 1013 NA FT RESPONSE TO DNA DAMAGE ENDOMEMBRANE SYSTEM|NUCLEUS Sumoylated protein that localizes to a single spot on the nuclear periphery of mother cells but not daughters; interacts genetically with SMT3; UV-sensitive mutant phenotype and genetic interactions suggest a role in the DNA damage response protein sumoylation|response to UV-B|response to UV-C|response to DNA damage stimulus molecular_function nuclear envelope
YKL188C YKL188C PXA2 hom Verified 0.375646543258234 0.353589842083097 no 1613 0.344176563558869 1137 NA FT NUCLEOTIDE METABOLISM Subunit of a heterodimeric peroxisomal ATP-binding cassette transporter complex (Pxa1p-Pxa2p), required for import of long-chain fatty acids into peroxisomes; similarity to human adrenoleukodystrophy transporter ABCD1 and ABCD2 and ALD-related proteins; mutations in ABCD1 cause X-linked adrenoleukodystrophy (X-ALD), a peroxisomal disorder fatty acid transport ATPase activity, coupled to transmembrane movement of substances integral to membrane|integral to peroxisomal membrane
YOR220W YOR220W RCN2 hom Verified 0.372851982527234 0.354629305737711 no 1614 0.34906689365551 1186 NA Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; phosphorylated in response to alpha factor; protein abundance increases in response to DNA replication stress biological_process molecular_function cytoplasm
YCR004C YCR004C YCP4 hom Verified 0.371717125804068 0.355051736354539 no 1615 0.345818400860915 1128 NA FT OXIDATION-REDUCTION PROCESS MITOCHONDRION Protein of unknown function, has sequence and structural similarity to flavodoxins; predicted to be palmitoylated; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process electron carrier activity mitochondrion|membrane raft|plasma membrane|cytoplasm
YOR093C_p YOR093C YOR093C hom Uncharacterized 0.371506054271322 0.355130323722381 no 1616 0.318841357876863 1049 NA FT NUCLEUS Putative protein of unknown function; deletion causes sensitivity to unfolded protein response-inducing agents biological_process molecular_function integral to membrane
YLR369W YLR369W SSQ1 hom Verified 0.371504742591263 0.35513081211392 no 1617 0.350130959594839 1135 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS|COFACTOR METABOLISM MITOCHONDRION Mitochondrial hsp70-type molecular chaperone, required for assembly of iron/sulfur clusters into proteins at a step after cluster synthesis, and for maturation of Yfh1p, which is a homolog of human frataxin implicated in Friedreich's ataxia iron-sulfur cluster assembly|intracellular sequestering of iron ion|protein maturation unfolded protein binding mitochondrion|mitochondrial matrix
YNL201C YNL201C PSY2 hom Verified 0.371006632021307 0.355316296025008 no 1618 0.401587884113215 1296 NA FT CELL CYCLE|SIGNALING|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME Subunit of protein phosphatase PP4 complex; active complex is composed of catalytic subunit Pph3p and Psy2p, with Psy4p apparently providing additional substrate specificity in some cases; regulates recovery from the DNA damage checkpoint and also the gene conversion- and single-strand annealing-mediated pathways of meiotic double-strand break repair; Pph3p and Psy2p localize to foci on meiotic chromosomes; putative homolog of mammalian R3 Unknown|response to DNA damage stimulus|protein dephosphorylation|signal transduction involved in meiotic recombination checkpoint protein serine/threonine phosphatase activity condensed nuclear chromosome|nucleus
YHL033C YHL033C RPL8A hom Verified 0.370574800313741 0.355477127090111 no 1619 0.329059221509897 1103 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Ribosomal 60S subunit protein L8A; mutation results in decreased amounts of free 60S subunits; homologous to mammalian ribosomal protein L7A, no bacterial homolog; RPL8A has a paralog, RPL8B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YLR102C YLR102C APC9 hom Verified 0.369538291570292 0.355863268586 no 1620 0.346887222846381 1147 NA FT CELL CYCLE|CHROMATIN ORGANIZATION|CELL DIVISION NUCLEUS UBIQUITIN LIGASE COMPLEX Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition chromatin assembly|protein ubiquitination ubiquitin-protein ligase activity anaphase-promoting complex
YOR067C YOR067C ALG8 hom Verified 0.369428067584011 0.355904340194447 no 1621 0.380300675595171 1284 NA FF|FT LIPID METABOLISM|CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Glucosyl transferase, involved in N-linked glycosylation; adds glucose to the dolichol-linked oligosaccharide precursor prior to transfer to protein during lipid-linked oligosaccharide biosynthesis; similar to Alg6p oligosaccharide-lipid intermediate biosynthetic process|protein N-linked glycosylation dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity integral to membrane|endoplasmic reticulum membrane
YBR275C YBR275C RIF1 hom Verified 0.36912768492326 0.356016277124291 no 1622 0.338943576656881 1126 NA FT CELL CYCLE|GENE SILENCING NUCLEUS|CHROMOSOME Protein that binds to the Rap1p C-terminus and acts synergistically with Rif2p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation telomere capping|telomere maintenance|chromatin silencing at silent mating-type cassette telomeric DNA binding nuclear telomere cap complex
YDR354W YDR354W TRP4 hom Verified 0.368866873676235 0.356113477922407 no 1623 0.463056754846589 1526 NA FF|FT KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS Anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosphoribosylation of anthranilate, subject to the general control system of amino acid biosynthesis tryptophan biosynthetic process anthranilate phosphoribosyltransferase activity nucleus|cytoplasm
YGR164W_d YGR164W YGR164W hom Dubious 0.368835152211859 0.356125300717946 no 1624 0.355364191686795 1222 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YDR281C YDR281C PHM6 hom Verified 0.367511077001827 0.356618915402736 no 1625 0.368925955886137 1253 NA Protein of unknown function, expression is regulated by phosphate levels biological_process molecular_function fungal-type vacuole
YDR483W YDR483W KRE2 hom Verified 0.367459742266334 0.356638057813488 no 1626 0.390821982591953 1271 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Alpha1,2-mannosyltransferase of the Golgi; involved in protein mannosylation; KRE2 has a paralog, KTR6, that arose from the whole genome duplication N-glycan processing|cell wall mannoprotein biosynthetic process|protein O-linked glycosylation alpha-1,2-mannosyltransferase activity Golgi apparatus
YMR147W_p YMR147W YMR147W hom Uncharacterized 0.367031485508844 0.356797766222057 no 1627 0.337766604737245 1126 NA Putative protein of unknown function biological_process molecular_function cellular_component
YOL038C-A_p YOL038C-A YOL038C-A hom Uncharacterized 0.36644370484731 0.357017006234336 no 1628 0.335419631144868 1091 NA Putative protein of unknown function; identified by SAGE analysis biological_process molecular_function cellular_component
YNL154C YNL154C YCK2 hom Verified 0.366295142958472 0.357072426748661 no 1629 0.363562620960173 1238 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CELL DIVISION|PROTEIN PHOSPHORYLATION SITE OF POLARIZED GROWTH|PLASMA MEMBRANE Palmitoylated plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck1p in morphogenesis, proper septin assembly, endocytic trafficking; YCK2 has a paralog, YCK1, that arose from the whole genome duplication endocytosis|cell morphogenesis|protein phosphorylation|cytokinesis|response to glucose stimulus protein serine/threonine kinase activity|protein kinase activity plasma membrane|cellular bud neck|mating projection
YKL198C YKL198C PTK1 hom Verified 0.36605370363197 0.357162501312648 no 1630 0.352076229836787 1186 NA FT PROTEIN PHOSPHORYLATION Putative serine/threonine protein kinase that regulates spermine uptake; involved in polyamine transport; possible mitochondrial protein polyamine transport protein kinase activity cellular_component
YMR264W YMR264W CUE1 hom Verified 0.365799162595546 0.357257472395434 no 1631 0.372536429355799 1239 NA FF|FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|PROTEOLYSIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION UBIQUITIN LIGASE COMPLEX Ubiquitin-binding protein; endoplasmic reticulum membrane protein that recruits the ubiquitin-conjugating enzyme Ubc7p to the ER where it functions in protein degradation; contains a CUE domain that binds ubiquitin to facilitate intramolecular monoubiquitination; CUE1 has a paralog, CUE4, that arose from the whole genome duplication ER-associated protein catabolic process|establishment of protein localization to endoplasmic reticulum membrane ubiquitin-protein ligase activator activity Doa10p ubiquitin ligase complex|mitochondrion|integral to endoplasmic reticulum membrane
YMR252C_p YMR252C YMR252C hom Uncharacterized 0.365624676111046 0.357322579660897 no 1632 0.350392628515144 1171 NA FT MITOCHONDRION Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YMR252C is not an essential gene biological_process molecular_function mitochondrion
YDR522C YDR522C SPS2 hom Verified 0.365346040776844 0.357426557269222 no 1633 0.337064865332464 1133 NA FT CELL CYCLE|CELL WALL ORG/BIOGENESIS PLASMA MEMBRANE Protein expressed during sporulation; SPS2 has a paralog, SPS22, that arose from the whole genome duplication; redundant with Sps22p for organization of the beta-glucan layer of the spore wall; S. pombe ortholog is a spore wall component ascospore wall assembly|ascospore formation molecular_function fungal-type cell wall|plasma membrane
YDL054C YDL054C MCH1 hom Verified 0.364476543523653 0.357751093275305 no 1634 0.361582233644507 1249 NA Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport transport monocarboxylic acid transmembrane transporter activity|transporter activity integral to membrane|membrane
YGL067W YGL067W NPY1 hom Verified 0.364421197363405 0.357771754469445 no 1635 0.318579129175114 1054 NA FT NUCLEOTIDE METABOLISM|COFACTOR METABOLISM NADH diphosphatase (pyrophosphatase), hydrolyzes the pyrophosphate linkage in NADH and related nucleotides; localizes to peroxisomes; nudix hydrolase family member NADH metabolic process NAD+ diphosphatase activity peroxisome|cytoplasm
YDR403W YDR403W DIT1 hom Verified 0.364081067381809 0.357898737043168 no 1636 0.349718308052351 1167 NA FT CELL WALL ORG/BIOGENESIS Sporulation-specific enzyme required for spore wall maturation, involved in the production of a soluble LL-dityrosine-containing precursor of the spore wall; transcripts accumulate at the time of prospore enclosure ascospore wall assembly catalytic activity cellular_component
YKL106C-A_p YKL106C-A YKL106C-A hom Uncharacterized 0.36399563904035 0.357930632941359 no 1637 0.34356573925062 1149 NA Putative protein of unknown function; identified by homology to uncharacterized proteins in other fungi biological_process molecular_function cellular_component
YKR035W-A YKR035W-A DID2 hom Verified 0.363563630778649 0.358091944616014 no 1638 0.357397659229127 1186 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM Class E protein of the vacuolar protein-sorting (Vps) pathway; binds Vps4p and directs it to dissociate ESCRT-III complexes; forms a functional and physical complex with Ist1p; human ortholog may be altered in breast tumors late endosome to vacuole transport via multivesicular body sorting pathway|late endosome to vacuole transport|protein targeting to vacuole molecular_function late endosome|cytoplasm
YDR157W_d YDR157W YDR157W hom Dubious 0.361109923049873 0.359008637770305 no 1639 0.358278342829453 1171 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YOR263C_d YOR263C YOR263C hom Dubious 0.359873636670261 0.359470816445707 no 1640 0.358718270749214 1210 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF DES3/YOR264W Unknown Unknown Unknown
YOR237W YOR237W HES1 hom Verified 0.357369723945376 0.360407519538213 no 1641 0.386799810073554 1292 NA FT VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|MEMBRANE ORGANIZATION Protein implicated in the regulation of ergosterol biosynthesis; one of a seven member gene family with a common essential function and non-essential unique functions; similar to human oxysterol binding protein (OSBP); HES1 has a paralog, KES1, that arose from the whole genome duplication maintenance of cell polarity|endocytosis|exocytosis|sterol transport lipid binding|oxysterol binding|sterol transporter activity cellular_component
YJR025C YJR025C BNA1 hom Verified 0.356954832787857 0.360562809676763 no 1642 0.34508931012151 1146 NA FT OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM NUCLEUS 3-hydroxyanthranilic acid dioxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p de novo NAD biosynthetic process from tryptophan 3-hydroxyanthranilate 3,4-dioxygenase activity cytoplasm
YFR014C YFR014C CMK1 hom Verified 0.356242091588326 0.36082963616683 no 1643 0.345166283382096 1137 NA FT SIGNALING|PROTEIN PHOSPHORYLATION Calmodulin-dependent protein kinase; may play a role in stress response, many Ca++/calmodulin dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to mammalian Cam Kinase II; CMK1 has a paralog, CMK2, that arose from the whole genome duplication signal transduction|protein phosphorylation protein kinase activity|calmodulin-dependent protein kinase activity cytoplasm
YKR031C YKR031C SPO14 hom Verified 0.355152313698303 0.361237743559634 no 1644 0.359779891092486 1212 NA FT VESICLE-MEDIATED TRANSPORT|CELL CYCLE|LIPID METABOLISM NUCLEUS Phospholipase D; catalyzes the hydrolysis of phosphatidylcholine, producing choline and phosphatidic acid; involved in Sec14p-independent secretion; required for meiosis and spore formation; differently regulated in secretion and meiosis; participates in transcription initiation and/or early elongation of specific genes; interacts with foot domain of RNA polymerase II; deletion results in abnormal CTD-Ser5 phosphorylation of RNA polymerase II at specific promoter regions phospholipid metabolic process|exocytosis|cell morphogenesis involved in conjugation with cellular fusion|ascospore-type prospore assembly phospholipase D activity|phosphatidylinositol-3-phosphate binding endosome|nucleus|prospore membrane
YGL028C YGL028C SCW11 hom Verified 0.355108298293551 0.361254230068142 no 1645 0.371188396898338 1235 NA FT CELL WALL ORG/BIOGENESIS|CELL DIVISION|CARBOHYDRATE METABOLISM Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on its regulation by Ste12p cytokinesis, completion of separation glucan endo-1,3-beta-D-glucosidase activity fungal-type cell wall
YMR319C YMR319C FET4 hom Verified 0.354829441527207 0.361358685269294 no 1646 0.397665445436274 1295 NA FF|FT ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE Low-affinity Fe(II) transporter of the plasma membrane intracellular copper ion transport|zinc ion transport|low-affinity iron ion transport|copper ion import copper ion transmembrane transporter activity|iron ion transmembrane transporter activity integral to membrane|plasma membrane|integral to plasma membrane
YKR048C YKR048C NAP1 hom Verified 0.352687607807758 0.362161325331434 no 1647 0.374627982165932 1249 NA FT PROTEIN LOCALIZATION|CELL CYCLE|CHROMATIN ORGANIZATION|CELL DIVISION NUCLEUS|SITE OF POLARIZED GROWTH|CHROMOSOME Protein that interacts with mitotic cyclin Clb2p; required for the regulation of microtubule dynamics during mitosis; controls bud morphogenesis; involved in the transport of H2A and H2B histones to the nucleus; phosphorylated by CK2; protein abundance increases in response to DNA replication stress budding cell bud growth|M phase of mitotic cell cycle|nucleosome disassembly|protein import into nucleus|nucleosome assembly cyclin binding|histone binding nucleus|nuclear nucleosome|cytoplasm
YLR267W_p YLR267W BOP2 hom Uncharacterized 0.352507715735551 0.362228766523014 no 1648 0.321239759231927 1064 NA Protein of unknown function biological_process molecular_function cellular_component
YDR150W YDR150W NUM1 hom Verified 0.351030965958566 0.362782558657463 no 1649 0.386790707011865 1283 NA FT PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION MITOCHONDRION|SITE OF POLARIZED GROWTH Protein required for nuclear migration, localizes to the mother cell cortex and the bud tip; may mediate interactions of dynein and cytoplasmic microtubules with the cell cortex mitochondrion inheritance|nuclear migration along microtubule|mitochondrial fission|microtubule cytoskeleton organization tubulin binding cell cortex|mitochondrion|cellular bud tip
YKL007W YKL007W CAP1 hom Verified 0.347844525889439 0.363978474221147 no 1650 0.362031405026489 1210 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH|CYTOSKELETON Alpha subunit of the capping protein heterodimer (Cap1p and Cap2p); capping protein (CP) binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches; protein increases in abundance and relocalizes from bud neck to plasma membrane upon DNA replication stress barbed-end actin filament capping actin filament binding actin filament|F-actin capping protein complex|mating projection tip|actin cortical patch
YKR070W_p YKR070W YKR070W hom Uncharacterized 0.347608649968434 0.364067054609535 no 1651 0.354038918245392 1149 NA FT MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process molecular_function mitochondrion
YJL172W YJL172W CPS1 hom Verified 0.347599897565918 0.364070341609675 no 1652 0.381554357426827 1233 NA FT PROTEOLYSIS Vacuolar carboxypeptidase yscS; expression is induced under low-nitrogen conditions nitrogen compound metabolic process|proteolysis involved in cellular protein catabolic process carboxypeptidase activity fungal-type vacuole lumen
YDR512C YDR512C EMI1 hom Verified 0.346618816841659 0.364438853774381 no 1653 0.352285612493111 1160 NA FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|MITOCHONDRION ORGANIZATION Non-essential protein required for transcriptional induction of the early meiotic-specific transcription factor IME1, also required for sporulation; contains twin cysteine-x9-cysteine motifs ascospore formation|mitochondrial respiratory chain complex assembly|positive regulation of transcription from RNA polymerase II promoter molecular_function cellular_component
YOL090W YOL090W MSH2 hom Verified 0.346028704400911 0.364660571369213 no 1654 0.371730487246515 1250 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|GENE SILENCING NUCLEUS|CHROMOSOME Protein that forms heterodimers with Msh3p and Msh6p that bind to DNA mismatches to initiate the mismatch repair process; contains a Walker ATP-binding motif required for repair activity and involved in interstrand cross-link repair; Msh2p-Msh6p binds to and hydrolyzes ATP mismatch repair|mitotic recombination|meiotic gene conversion|meiotic mismatch repair|removal of nonhomologous ends|DNA recombination|chromatin silencing at silent mating-type cassette loop DNA binding|single base insertion or deletion binding|ATP binding|Y-form DNA binding|double-strand/single-strand DNA junction binding|DNA insertion or deletion binding|guanine/thymine mispair binding|four-way junction DNA binding|ATPase activity MutSbeta complex|nuclear chromosome|MutSalpha complex|nucleus
YGL088W_d YGL088W YGL088W hom Dubious 0.345661745864057 0.364798468208616 no 1655 0.359384339094961 1212 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps snR10, a snoRNA required for preRNA processing Unknown Unknown Unknown
YDL035C YDL035C GPR1 hom Verified 0.345547602142232 0.364841365064898 no 1656 0.380728399557871 1265 NA FT SIGNALING PLASMA MEMBRANE Plasma membrane G protein coupled receptor (GPCR) that interacts with the heterotrimeric G protein alpha subunit, Gpa2p, and with Plc1p; sensor that integrates nutritional signals with the modulation of cell fate via PKA and cAMP synthesis replicative cell aging|G-protein coupled receptor signaling pathway|sucrose mediated signaling|glucose mediated signaling pathway|pseudohyphal growth|hexose mediated signaling|invasive growth in response to glucose limitation|detection of glucose|detection of sucrose stimulus G-protein coupled receptor activity|glucose binding integral to membrane|plasma membrane
YMR318C YMR318C ADH6 hom Verified 0.345192089766606 0.364974982580516 no 1657 0.350257342307087 1158 NA FT OXIDATION-REDUCTION PROCESS NADPH-dependent medium chain alcohol dehydrogenase; has broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance; protein abundance increases in response to DNA replication stress cellular aldehyde metabolic process|furaldehyde metabolic process|alcohol metabolic process hydroxymethylfurfural reductase (NADH) activity|hydroxymethylfurfural reductase (NADPH) activity|alcohol dehydrogenase (NADP+) activity cellular_component
YBR095C YBR095C RXT2 hom Verified 0.34392727988028 0.36545048778263 no 1658 0.389083157274218 1263 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS|CHROMOSOME Subunit of the histone deacetylase Rpd3L complex; possibly involved in cell fusion and invasive growth conjugation with cellular fusion|negative regulation of chromatin silencing at silent mating-type cassette|negative regulation of transcription from RNA polymerase II promoter|negative regulation of chromatin silencing at telomere|negative regulation of chromatin silencing at rDNA|invasive growth in response to glucose limitation histone deacetylase activity Rpd3L-Expanded complex|nucleus|Rpd3L complex
YLL017W YLL017W YLL017W hom pseudogene 0.343390154563355 0.365652482638556 no 1659 0.330682796999541 1102 NA FT SIGNALING Non-essential Ras guanine nucleotide exchange factor (GEF); localized to the membrane; expressed in poor nutrient conditions and on nonfermentable carbon sources; contains a stop codon in S288C, full-length gene includes YLL016W; SDC25 has a paralog, CDC25, that arose from the whole genome duplication Ras protein signal transduction Ras guanyl-nucleotide exchange factor activity membrane
YOR277C_d YOR277C YOR277C hom Dubious 0.343113038639216 0.365756711237326 no 1660 0.379797313838302 1286 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the verified gene CAF20 Unknown Unknown Unknown
YPL271W YPL271W ATP15 hom Verified 0.342688709169377 0.365916328870188 no 1661 0.394673837816887 1283 NA FT ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS MITOCHONDRION Epsilon subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated ATP synthesis coupled proton transport hydrogen ion transporting ATP synthase activity, rotational mechanism|ATPase activity|proton-transporting ATPase activity, rotational mechanism proton-transporting ATP synthase complex, catalytic core F(1)|mitochondrion|integral to membrane|mitochondrial proton-transporting ATP synthase, central stalk
YGL105W YGL105W ARC1 hom Verified 0.342572865134702 0.365959909304526 no 1662 0.3759579254832 1269 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION Protein that binds tRNA and methionyl- and glutamyl-tRNA synthetases (Mes1p and Gus1p), delivering tRNA to them, stimulating catalysis, and ensuring their localization to the cytoplasm; also binds quadruplex nucleic acids; protein abundance increases in response to DNA replication stress positive regulation of ligase activity|tRNA aminoacylation for protein translation enzyme activator activity|tRNA binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding methionyl glutamyl tRNA synthetase complex|cytoplasm
YJL205C YJL205C NCE101 hom Verified 0.342223464087396 0.366091364175456 no 1663 0.341890199302696 1166 NA FT PROTEIN LOCALIZATION Protein of unknown function, involved in secretion of proteins that lack classical secretory signal sequences protein secretion molecular_function cellular_component
YBL011W YBL011W SCT1 hom Verified 0.341857500217088 0.366229067318349 no 1664 0.359541620982637 1196 NA FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Glycerol 3-phosphate/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase of the glycerolipid biosynthesis pathway, prefers 16-carbon fatty acids, similar to Gpt2p, gene is constitutively transcribed phospholipid biosynthetic process glycerol-3-phosphate O-acyltransferase activity|glycerone-phosphate O-acyltransferase activity integral to membrane|endoplasmic reticulum
YJL141C YJL141C YAK1 hom Verified 0.34147538877049 0.366372864779951 no 1665 0.360761068622619 1191 NA FT PROTEIN PHOSPHORYLATION NUCLEUS Serine-threonine protein kinase; component of a glucose-sensing system that inhibits growth in response to glucose availability; upon nutrient deprivation Yak1p phosphorylates Pop2p to regulate mRNA deadenylation, the co-repressor Crf1p to inhibit transcription of ribosomal genes, and the stress-responsive transcription factors Hsf1p and Msn2p; nuclear localization negatively regulated by the Ras/PKA signaling pathway in the presence of glucose protein phosphorylation protein serine/threonine kinase activity|protein tyrosine kinase activity|protein kinase activity nucleus|cytoplasm
YMR233W YMR233W TRI1 hom Verified 0.339500961602446 0.367116186400269 no 1666 0.378547700389947 1255 NA FT NUCLEUS Non-essential sumoylated protein of unknown function; similar to components of human SWI/SNF complex including SMRD3; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm, nucleus and nucleolus; TRI1 has a paralog, UAF30, that arose from the whole genome duplication biological_process molecular_function nucleolus|nucleus|cytoplasm
YDR479C YDR479C PEX29 hom Verified 0.338423794212149 0.367521922831655 no 1667 0.377490620690057 1286 NA FT PEROXISOME ORGANIZATION Peroxisomal integral membrane peroxin; involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p; forms ER foci upon DNA replication stress peroxisome organization molecular_function integral to membrane|peroxisomal membrane
YNR042W_d YNR042W YNR042W hom Dubious 0.338408064671406 0.367527848771609 no 1668 0.363732663372566 1190 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2 Unknown Unknown Unknown
YDR065W YDR065W RRG1 hom Verified 0.338053365790845 0.367661486238094 no 1669 0.361837841479847 1211 NA FT ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS MITOCHONDRION Protein of unknown function, required for vacuolar acidification and mitochondrial genome maintenance; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies mitochondrial genome maintenance|vacuolar acidification molecular_function mitochondrion
YJL124C YJL124C LSM1 hom Verified 0.337476969253717 0.367878685384201 no 1670 0.381658395438165 1269 NA FF|FT RNA PROCESSING NUCLEUS Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) involved in degradation of cytoplasmic mRNAs; unlike most Sm-like proteins, Lsm1p requires both its SM-domain and C-terminal domain for RNA-binding; forms cytoplasmic foci upon DNA replication stress deadenylation-dependent decapping of nuclear-transcribed mRNA|nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay RNA binding|RNA cap binding mRNA cap binding complex|cytoplasmic mRNA processing body|cytoplasm
YAR002W YAR002W NUP60 hom Verified 0.336659594610641 0.368186762916022 no 1671 0.375278016942167 1249 NA FT PROTEIN LOCALIZATION|RESPONSE TO DNA DAMAGE|RNA LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS NUCLEAR PORE FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier and is involved in gene tethering at the nuclear periphery; both NUP1 and NUP60 are homologous to human NUP153 double-strand break repair|poly(A)+ mRNA export from nucleus|protein export from nucleus|regulation of protein desumoylation|intracellular mRNA localization|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|telomere tethering at nuclear periphery|mRNA export from nucleus in response to heat stress|transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery|NLS-bearing substrate import into nucleus|chromosome organization|nucleocytoplasmic transport|chromatin silencing at silent mating-type cassette nucleocytoplasmic transporter activity|phospholipid binding|structural constituent of nuclear pore nuclear pore central transport channel|nuclear pore nuclear basket|integral to membrane|nuclear pore
YPL042C YPL042C SSN3 hom Verified 0.335698225795049 0.368549221936623 no 1672 0.386922974343443 1295 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS NUCLEUS Cyclin-dependent protein kinase, component of RNA polymerase II holoenzyme; involved in phosphorylation of the RNA polymerase II C-terminal domain; involved in glucose repression phosphorylation of RNA polymerase II C-terminal domain|negative regulation of transcription from RNA polymerase II promoter|negative regulation of filamentous growth|protein phosphorylation|protein destabilization|nuclear-transcribed mRNA catabolic process, non-stop decay|positive regulation of transcription from RNA polymerase II promoter by galactose RNA polymerase II carboxy-terminal domain kinase activity|protein kinase activity|cyclin-dependent protein kinase activity mediator complex
YNR050C YNR050C LYS9 hom Verified 0.335081036324327 0.368781978801646 no 1673 0.378085845427399 1247 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS Saccharopine dehydrogenase (NADP+, L-glutamate-forming); catalyzes the formation of saccharopine from alpha-aminoadipate 6-semialdehyde, the seventh step in lysine biosynthesis pathway; exhibits genetic and physical interactions with TRM112 lysine biosynthetic process via aminoadipic acid saccharopine dehydrogenase (NADP+, L-glutamate-forming) activity cytoplasm
YHR091C YHR091C MSR1 hom Verified 0.332805942833081 0.369640385997076 no 1674 0.350043541287515 1176 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial arginyl-tRNA synthetase; mutations in human ortholog are associated with pontocerebellar hypoplasia type 6 arginyl-tRNA aminoacylation|mitochondrial arginyl-tRNA aminoacylation|mitochondrial translation arginine-tRNA ligase activity mitochondrion
YOL089C YOL089C HAL9 hom Verified 0.331410865513721 0.370167079355894 no 1675 0.316706742773878 1087 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS|MITOCHONDRION Putative transcription factor containing a zinc finger; overexpression increases salt tolerance through increased expression of the ENA1 (Na+/Li+ extrusion pump) gene while gene disruption decreases both salt tolerance and ENA1 expression; HAL9 has a paralog, TBS1, that arose from the whole genome duplication response to salt stress|positive regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding mitochondrion|nucleus
YIL145C YIL145C PAN6 hom Verified 0.331176521076578 0.370255576979155 no 1676 0.350478525234738 1139 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM NUCLEUS Pantothenate synthase, also known as pantoate-beta-alanine ligase, required for pantothenic acid biosynthesis, deletion causes pantothenic acid auxotrophy, homologous to E. coli panC pantothenate biosynthetic process pantoate-beta-alanine ligase activity nucleus|cytoplasm
YLR019W YLR019W PSR2 hom Verified 0.330609389073835 0.370469776616877 no 1677 0.372334537203567 1235 NA FT PLASMA MEMBRANE Functionally redundant Psr1p homolog, a plasma membrane phosphatase involved in the general stress response; required with Psr1p and Whi2p for full activation of STRE-mediated gene expression, possibly through dephosphorylation of Msn2p response to stress phosphoprotein phosphatase activity plasma membrane
YPR184W YPR184W GDB1 hom Verified 0.330230272933934 0.370612987095269 no 1678 0.377459307166737 1265 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY NUCLEUS|MITOCHONDRION Glycogen debranching enzyme; contains glucanotranferase and alpha-1,6-amyloglucosidase activities; required for glycogen degradation; phosphorylated in mitochondria; activity is inhibited by Igd1p; protein abundance increases in response to DNA replication stress glycogen catabolic process 4-alpha-glucanotransferase activity|amylo-alpha-1,6-glucosidase activity mitochondrion|cytoplasm
YIL140W YIL140W AXL2 hom Verified 0.329815347948717 0.370769744854361 no 1679 0.365657194322776 1214 NA FT CELL CYCLE|CELL DIVISION SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON Integral plasma membrane protein required for axial budding in haploid cells, localizes to the incipient bud site and bud neck; glycosylated by Pmt4p; potential Cdc28p substrate axial cellular bud site selection|cellular bud site selection molecular_function integral to plasma membrane|cellular bud neck|septin ring
YKL071W_p YKL071W YKL071W hom Uncharacterized 0.329470126206296 0.370900185230892 no 1680 0.374222961903099 1241 NA FT OXIDATION-REDUCTION PROCESS Putative protein of unknown function; expression induced in cells treated with the mycotoxin patulin, and also the quinone methide triterpene celastrol; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm biological_process molecular_function integral to membrane|cytoplasm
YOR185C YOR185C GSP2 hom Verified 0.329371664112256 0.370937391379968 no 1681 0.389629302798572 1289 NA FT PROTEIN LOCALIZATION|SIGNALING|NUCLEOTIDE METABOLISM NUCLEUS GTP binding protein (mammalian Ranp homolog); involved in the maintenance of nuclear organization, RNA processing and transport; interacts with Kap121p, Kap123p and Pdr6p (karyophilin betas); Gsp1p homolog that is not required for viability; protein abundance increases in response to DNA replication stress nucleus organization GTPase activity integral to membrane|nucleus
YOR132W YOR132W VPS17 hom Verified 0.329369579437414 0.370938179134973 no 1682 0.370033018046401 1243 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM Subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde protein transport; peripheral membrane protein that assembles onto the membrane with Vps5p to promote vesicle formation; required for recruiting the retromer complex to the endosome membranes retrograde transport, endosome to Golgi protein transporter activity|phosphatidylinositol-3-phosphate binding endosome|retromer complex, outer shell|retromer complex
YOL071W YOL071W EMI5 hom Verified 0.329321382895683 0.370956391750484 no 1683 0.334973883682375 1124 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION Subunit of succinate dehydrogenase, which couples succinate oxidation to ubiquinone reduction; required for FAD cofactor attachment to Sdh1p; mutations in human ortholog PGL2 are associated with neuroendocrine tumors (paraganglioma) protein-FAD linkage|cellular respiration|mitochondrial electron transport, succinate to ubiquinone|ascospore formation|tricarboxylic acid cycle|positive regulation of transcription from RNA polymerase II promoter succinate dehydrogenase (ubiquinone) activity mitochondrial respiratory chain complex II|mitochondrion|mitochondrial matrix
YIR039C YIR039C YPS6 hom Verified 0.328715188318328 0.371185486565283 no 1684 0.396111873820631 1324 NA FT CELL WALL ORG/BIOGENESIS|PROTEOLYSIS PLASMA MEMBRANE Putative GPI-anchored aspartic protease, member of the yapsin family of proteases involved in cell wall growth and maintenance fungal-type cell wall organization aspartic-type endopeptidase activity fungal-type cell wall
YBR133C YBR133C HSL7 hom Verified 0.327761202439073 0.371546112109454 no 1685 0.376515927047289 1275 NA FT CELL CYCLE|CHROMATIN ORGANIZATION|CELL DIVISION SITE OF POLARIZED GROWTH Protein arginine N-methyltransferase; exhibits septin and Hsl1p-dependent bud neck localization and periodic Hsl1p-dependent phosphorylation; required along with Hsl1p for bud neck recruitment, phosphorylation, and degradation of Swe1p; relocalizes away from bud neck upon DNA replication stress G2/M transition of mitotic cell cycle|regulation of cell cycle protein-arginine omega-N symmetric methyltransferase activity|protein-arginine omega-N monomethyltransferase activity cellular bud neck
YOR058C YOR058C ASE1 hom Verified 0.327166319400516 0.371771046780388 no 1686 0.347998477335665 1172 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION NUCLEUS|CYTOSKELETON Mitotic spindle midzone localized protein; microtubule-associated protein (MAP) family member; required for spindle elongation and stabilization; undergoes cell cycle-regulated degradation by anaphase promoting complex; potential Cdc28p substrate; relative distribution to microtubules decreases upon DNA replication stress cytokinesis, completion of separation|mitotic anaphase B|microtubule bundle formation|spindle pole body separation|spindle midzone assembly|mitotic spindle stabilization|mitotic spindle elongation microtubule binding spindle midzone|nuclear microtubule|spindle
YBR299W YBR299W MAL32 hom Verified 0.326918340243651 0.371864824548998 no 1687 0.372343704087166 1244 NA FT CARBOHYDRATE METABOLISM Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL3 complex locus; functional in genomic reference strain S288C; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose sucrose catabolic process|maltose catabolic process sucrose alpha-glucosidase activity|alpha-glucosidase activity|maltose alpha-glucosidase activity plasma membrane
YML088W YML088W UFO1 hom Verified 0.326704189320394 0.371945815681954 no 1688 0.368425611319715 1227 NA FT RESPONSE TO DNA DAMAGE|PROTEOLYSIS NUCLEUS UBIQUITIN LIGASE COMPLEX F-box receptor protein, subunit of the Skp1-Cdc53-F-box receptor (SCF) E3 ubiquitin ligase complex; binds to phosphorylated Ho endonuclease, allowing its ubiquitylation by SCF and subsequent degradation SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|cellular response to methylmercury|response to DNA damage stimulus ubiquitin-protein ligase activity|protein binding, bridging SCF ubiquitin ligase complex|nucleus|cytoplasm
YPL074W YPL074W YTA6 hom Verified 0.322741189617189 0.37344562759388 no 1689 0.334234424435304 1132 NA Putative ATPase of the CDC48/PAS1/SEC18 (AAA) family; localized to the cortex of mother cells but not to daughter cells; relocalizes from cytoplasm to plasma membrane foci upon DNA replication stress biological_process ATPase activity cell cortex
YML120C YML120C NDI1 hom Verified 0.322728508004087 0.373450430089639 no 1690 0.360433489066322 1189 NA FT OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION NADH:ubiquinone oxidoreductase; transfers electrons from NADH to ubiquinone in the respiratory chain but does not pump protons, in contrast to the higher eukaryotic multisubunit respiratory complex I; phosphorylated; involved in Mn and H2O2 induced apoptosis; upon apoptotic stress, Ndip is activated in the mitochondria by N-terminal cleavage, and the truncated protein translocates to the cytoplasm to induce apoptosis; homolog of human AMID mitochondrial electron transport, NADH to ubiquinone|NADH oxidation|chronological cell aging|positive regulation of apoptotic process NADH dehydrogenase (ubiquinone) activity mitochondrion|mitochondrial matrix
YLL062C YLL062C MHT1 hom Verified 0.322071074150222 0.373699425582295 no 1691 0.373541439092582 1255 NA FT KETONE METABOLISM|AMINO ACID METABOLISM S-methylmethionine-homocysteine methyltransferase, functions along with Sam4p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio sulfur amino acid metabolic process homocysteine S-methyltransferase activity cytoplasm
YEL039C YEL039C CYC7 hom Verified 0.321764333945888 0.37381561794404 no 1692 0.38455092483891 1256 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Cytochrome c isoform 2, expressed under hypoxic conditions; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration; protein abundance increases in response to DNA replication stress; CYC7 has a paralog, CYC1, that arose from the whole genome duplication mitochondrial electron transport, cytochrome c to oxygen|mitochondrial electron transport, ubiquinol to cytochrome c electron carrier activity mitochondrion|mitochondrial intermembrane space
YNL236W YNL236W SIN4 hom Verified 0.317883211722981 0.375286763850106 no 1693 0.407601925216149 1366 NA FF|FT TRANSCRIPTION FROM RNA POL II NUCLEUS RNA POL II, HOLOENZYME Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; contributes to both postive and negative transcriptional regulation; dispensible for basal transcription negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II transcriptional preinitiation complex assembly|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II activating transcription factor binding core mediator complex
YER089C YER089C PTC2 hom Verified 0.317480067652258 0.375439680750974 no 1694 0.350174197803661 1177 NA FT CELL CYCLE|SIGNALING|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION NUCLEUS Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p to limit maximal osmostress induced kinase activity; dephosphorylates Ire1p to downregulate the unfolded protein response; dephosphorylates Cdc28p; inactivates the DNA damage checkpoint; PTC2 has a paralog, PTC3, that arose from the whole genome duplication endoplasmic reticulum unfolded protein response|inactivation of MAPK activity involved in osmosensory signaling pathway|regulation of cyclin-dependent protein kinase activity|protein dephosphorylation|DNA damage checkpoint protein serine/threonine phosphatase activity nucleus|cytoplasm
YLR344W YLR344W RPL26A hom Verified 0.3166105494577 0.375769565000365 no 1695 0.364959277922566 1176 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L26A; binds to 5.8S rRNA; homologous to mammalian ribosomal protein L26 and bacterial L24; RPL26A has a paralog, RPL26B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome|RNA binding cytosolic large ribosomal subunit
YDR387C_p YDR387C YDR387C hom Uncharacterized 0.316027572750574 0.375990789896117 no 1696 0.362514301697437 1185 NA Putative transporter, member of the sugar porter family; YDR387C is not an essential gene transport|transmembrane transport substrate-specific transmembrane transporter activity integral to membrane|membrane
YER135C_d YER135C YER135C hom Dubious 0.315880322489279 0.376046674091751 no 1697 0.373644168331356 1223 NA Dubious open reading frame unlikely to encode a protein; YER135C is not an essential gene Unknown Unknown Unknown
YKL174C YKL174C TPO5 hom Verified 0.314881764180547 0.376425713953477 no 1698 0.365358873671357 1179 NA FT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Protein involved in excretion of putrescine and spermidine; putative polyamine transporter in the Golgi or post-Golgi vesicles polyamine transport polyamine transmembrane transporter activity integral to membrane|Golgi apparatus
YMR216C YMR216C SKY1 hom Verified 0.314803835815589 0.376455299574852 no 1699 0.426214971438426 1386 NA FF|FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|ION HOMEOSTASIS|PROTEIN PHOSPHORYLATION|ION HOMEOSTASIS SR protein kinase (SRPK) involved in regulating proteins involved in mRNA metabolism and cation homeostasis; similar to human SRPK1 cellular cation homeostasis|cellular ion homeostasis|response to drug|protein phosphorylation|positive regulation of protein import into nucleus|regulation of cell size|mRNA splice site selection protein serine/threonine kinase activity|protein kinase activity cytoplasm
YNR014W_p YNR014W YNR014W hom Uncharacterized 0.313869494408092 0.376810080174263 no 1700 0.385161321160034 1283 NA Putative protein of unknown function; expression is cell-cycle regulated, Azf1p-dependent, and heat-inducible; YNR014W has a paralog, YMR206W, that arose from the whole genome duplication biological_process molecular_function cytoplasm
YML001W YML001W YPT7 hom Verified 0.313781870576373 0.376843357331727 no 1701 0.366437167405661 1202 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING|VACUOLAR TRANSPORT MITOCHONDRION Rab family GTPase; GTP-binding protein of the rab family; required for homotypic fusion event in vacuole inheritance, for endosome-endosome fusion; interacts with the cargo selection/retromer complex for retrograde sorting; similar to mammalian Rab7 regulation of vacuole fusion, non-autophagic|piecemeal microautophagy of nucleus|vacuole inheritance|Golgi to vacuole transport|vesicle-mediated transport|endocytosis GTPase activity mitochondrial outer membrane|fungal-type vacuole
YIL064W YIL064W SEE1 hom Verified 0.313759689733421 0.376851781160105 no 1702 0.375315004007236 1231 NA FT VESICLE-MEDIATED TRANSPORT Probable lysine methyltransferase involved in the dimethylation of eEF1A (Tef1p/Tef2p); sequence similarity to S-adenosylmethionine-dependent methyltransferases of the seven beta-strand family; role in vesicular transport vesicle-mediated transport|peptidyl-lysine dimethylation protein-lysine N-methyltransferase activity cytoplasm
YKL212W YKL212W SAC1 hom Verified 0.312836982451977 0.377202258325997 no 1703 0.440206585333551 1443 NA FF|FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION|GOLGI APPARATUS Phosphatidylinositol phosphate (PtdInsP) phosphatase; involved in hydrolysis of PtdIns[4]P in the early and medial Golgi; regulated by interaction with Vps74p; ER localized transmembrane protein which cycles through the Golgi; involved in protein trafficking and processing, secretion, and cell wall maintenance; regulates sphingolipid biosynthesis through the modulation of PtdIns(4)P metabolism phosphatidylinositol dephosphorylation phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity|phosphatidylinositol-3-phosphatase activity|phosphatidylinositol-4-phosphate phosphatase activity mitochondrial outer membrane|integral to endoplasmic reticulum membrane|mitochondrion|SPOTS complex|integral to Golgi membrane
YER185W YER185W PUG1 hom Verified 0.312639740583116 0.377277190964774 no 1704 0.360824887022231 1195 NA FT PLASMA MEMBRANE Plasma membrane protein with roles in the uptake of protoprophyrin IX and the efflux of heme; expression is induced under both low-heme and low-oxygen conditions; member of the fungal lipid-translocating exporter (LTE) family of proteins heme transport molecular_function integral to membrane|plasma membrane
YOL160W_d YOL160W YOL160W hom Dubious 0.312590615040501 0.377295854590061 no 1705 0.363249964546965 1206 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YBR298C YBR298C MAL31 hom Verified 0.310757682573541 0.377992421153519 no 1706 0.385611870771385 1282 NA FT CARBOHYDRATE METABOLISM Maltose permease, high-affinity maltose transporter (alpha-glucoside transporter); encoded in the MAL3 complex locus; member of the 12 transmembrane domain superfamily of sugar transporters; functional in genomic reference strain S288C alpha-glucoside transport|transmembrane transport alpha-glucoside:hydrogen symporter activity integral to membrane|membrane
YOL055C YOL055C THI20 hom Verified 0.309787461537538 0.378361293564508 no 1707 0.368616105403309 1250 NA Trifunctional enzyme of thiamine biosynthesis, degradation and salvage; has hydroxymethylpyrimidine (HMP) kinase, HMP-phosphate (HMP-P) kinase and thiaminase activities; member of a gene family with THI21 and THI22; HMP and HMP-P kinase activity redundant with Thi21p thiamine biosynthetic process|thiamine catabolic process phosphomethylpyrimidine kinase activity|thiaminase activity|hydroxymethylpyrimidine kinase activity cytosol
YMR244C-A YMR244C-A COA6 hom Verified 0.309077294176811 0.378631365381139 no 1708 0.37348139769415 1242 NA FT NUCLEUS|MITOCHONDRION Protein involved in cytochrome c oxidase assembly; also required for efficient formation of respiratory supercomplexes comprised of Complexes III and IV; localizes to the mitochondrial intermembrane space; has a human homolog; transcription is induced in response to the DNA-damaging agent MMS; protein abundance increases in response to DNA replication stress biological_process molecular_function nucleus|cytoplasm
YLL054C_p YLL054C YLL054C hom Uncharacterized 0.30758339724155 0.379199677605884 no 1709 0.380078949938128 1253 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Putative protein of unknown function with similarity to Pip2p, an oleate-specific transcriptional activator of peroxisome proliferation; YLL054C is not an essential gene biological_process sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity cellular_component
YMR237W YMR237W BCH1 hom Verified 0.307579804657535 0.379201044621486 no 1710 0.383515231454602 1249 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM GOLGI APPARATUS Member of the ChAPs family (Chs5p-Arf1p-binding proteins); members include Bch1p, Bch2p, Bud7p, and Chs6p; ChAPs family proteins form the exomer complex with Chs5p to mediate export of specific cargo proteins from the Golgi to the plasma membrane; may interact with ribosomes; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress; BCH1 has a paralog, BUD7, that arose from the whole genome duplication Golgi to plasma membrane transport|fungal-type cell wall chitin biosynthetic process molecular_function ribosome|clathrin-coated vesicle|exomer complex
YDR251W YDR251W PAM1 hom Verified 0.306725463914036 0.379526173021138 no 1711 0.385979316705455 1270 NA FT OXIDATION-REDUCTION PROCESS SITE OF POLARIZED GROWTH Essential protein of unknown function; exhibits variable expression during colony morphogenesis; overexpression permits survival without protein phosphatase 2A, inhibits growth, and induces a filamentous phenotype pseudohyphal growth molecular_function cellular bud|cellular bud neck
YIL018W YIL018W RPL2B hom Verified 0.306713621714383 0.379530680294621 no 1712 0.356124679532819 1180 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L2B; homologous to mammalian ribosomal protein L2 and bacterial L2; RPL2B has a paralog, RPL2A, that arose from the whole genome duplication; expression is upregulated at low temperatures cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YOR019W YOR019W YOR019W hom Verified 0.306427850230849 0.379639453076705 no 1713 0.378934734576417 1251 NA FT CELL CYCLE Protein of unknown function that may interact with ribosomes, based on co-purification experiments mitochondrion degradation molecular_function ribosome
YLR142W YLR142W PUT1 hom Verified 0.306280059215226 0.379695710292432 no 1714 0.376542184497188 1246 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS MITOCHONDRION Proline oxidase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; PUT1 transcription is induced by Put3p in the presence of proline and the absence of a preferred nitrogen source glutamate biosynthetic process|proline catabolic process to glutamate proline dehydrogenase activity mitochondrion
YDR057W YDR057W YOS9 hom Verified 0.305947688795123 0.379822237666539 no 1715 0.377655811320624 1262 NA FT PROTEOLYSIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM UBIQUITIN LIGASE COMPLEX ER quality-control lectin; integral subunit of the HRD ligase; binds to glycans with terminal alpha-1,6 linked mannose on misfolded N-glycosylated proteins and participates in targeting proteins to ERAD; member of the OS-9 protein family ER-associated protein catabolic process oligosaccharide binding luminal surveillance complex|Hrd1p ubiquitin ligase ERAD-L complex|endoplasmic reticulum lumen
YOR080W YOR080W DIA2 hom Verified 0.305531036684457 0.379980867720706 no 1716 0.386221187069837 1282 NA FT CELL CYCLE|PROTEOLYSIS NUCLEUS|CHROMOSOME UBIQUITIN LIGASE COMPLEX Origin-binding F-box protein; forms an SCF ubiquitin ligase complex with Skp1p and Cdc53p; plays a role in DNA replication; plays a role in transcription; required for correct assembly of RSC complex, correct RSC-mediated transcription regulation, and correct nucleosome positioning; involved in invasive and pseudohyphal growth; required to target Cdc6p for ubiquitin-mediated destruction during G1 phase SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|regulation of DNA replication|invasive growth in response to glucose limitation|protein ubiquitination ubiquitin-protein ligase activity|DNA replication origin binding SCF ubiquitin ligase complex|nucleus|nuclear replication fork
YLL055W YLL055W YCT1 hom Verified 0.305052448251999 0.380163103427196 no 1717 0.353687011168845 1165 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|PLASMA MEMBRANE High-affinity cysteine-specific transporter with similarity to the Dal5p family of transporters; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YCT1 is not an essential gene cysteine transport ion transmembrane transporter activity|cysteine transmembrane transporter activity integral to membrane|endoplasmic reticulum
YHR180W_d YHR180W YHR180W hom Dubious 0.304408294712104 0.380408424600902 no 1718 0.372706721269696 1254 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YMR083W YMR083W ADH3 hom Verified 0.302517150338412 0.381128930737877 no 1719 0.383014125154531 1283 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION Mitochondrial alcohol dehydrogenase isozyme III; involved in the shuttling of mitochondrial NADH to the cytosol under anaerobic conditions and ethanol production NADH oxidation|fermentation|amino acid catabolic process to alcohol via Ehrlich pathway alcohol dehydrogenase (NAD) activity mitochondrion|mitochondrial matrix
YOR186W_p YOR186W YOR186W hom Uncharacterized 0.301950708448919 0.381344819498452 no 1720 0.368116315213249 1239 NA Putative protein of unknown function; proper regulation of expression during heat stress is sphingolipid-dependent; YOR186W has a paralog, YLR297W, that arose from the whole genome duplication biological_process molecular_function cellular_component
YGR137W_d YGR137W YGR137W hom Dubious 0.301709930346112 0.38143659876962 no 1721 0.37939338117105 1250 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YIL009W YIL009W FAA3 hom Verified 0.301607800266888 0.381475530504246 no 1722 0.37300892327039 1248 NA FT KETONE METABOLISM|LIPID METABOLISM Long chain fatty acyl-CoA synthetase, activates imported fatty acids; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery long-chain fatty acid metabolic process long-chain fatty acid-CoA ligase activity|very long-chain fatty acid-CoA ligase activity cellular_component
YOR190W YOR190W SPR1 hom Verified 0.301041785879974 0.381691315524541 no 1723 0.381546482482389 1272 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM Sporulation-specific exo-1,3-beta-glucanase; contributes to ascospore thermoresistance ascospore formation glucan exo-1,3-beta-glucosidase activity fungal-type cell wall|ascospore wall
YGR031W YGR031W IMO32 hom Verified 0.300395012659611 0.381937933725761 no 1724 0.385806602269961 1282 NA FT MITOCHONDRION Conserved mitochondrial protein of unknown function; processed by both mitochondrial processing peptidase and mitochondrial octapeptidyl aminopeptidase; gene contains the nested antisense gene NAG1 biological_process molecular_function mitochondrion
YPL096C-A YPL096C-A ERI1 hom Verified 0.299718546890264 0.382195925128229 no 1725 0.404229275956106 1335 NA FT LIPID METABOLISM|SIGNALING ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Endoplasmic reticulum membrane protein that binds to and inhibits GTP-bound Ras2p at the ER; component of the GPI-GnT complex which catalyzes the first step in GPI-anchor biosynthesis; probable homolog of mammalian PIG-Y protein GPI anchor biosynthetic process|Ras protein signal transduction GTPase inhibitor activity glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex|endoplasmic reticulum membrane
YDR034W-B_p YDR034W-B YDR034W-B hom Uncharacterized 0.299147606426751 0.382413711864046 no 1726 0.391619646525349 1286 NA Predicted tail-anchored plasma membrane protein containing a conserved CYSTM module; related proteins in other organisms may be involved in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery biological_process molecular_function cellular_component
YOR234C YOR234C RPL33B hom Verified 0.299104472401562 0.382430166963168 no 1727 0.368601708546149 1220 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L33B; rpl33b null mutant exhibits normal growth while rpl33a rpl33b double null mutant is inviable; homologous to mammalian ribosomal protein L35A, no bacterial homolog; RPL33B has a paralog, RPL33A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YJL007C_d YJL007C YJL007C hom Dubious 0.297396911244392 0.383081750770713 no 1728 0.384214485598992 1277 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YDL138W YDL138W RGT2 hom Verified 0.297264951347731 0.383132118802709 no 1729 0.369088951533516 1210 NA FT SIGNALING PLASMA MEMBRANE Plasma membrane high glucose sensor that regulates glucose transport; contains 12 predicted transmembrane segments and a long C-terminal tail required for induction of hexose transporters; RGT2 has a paralog, SNF3, that arose from the whole genome duplication glucose transport|signal transduction|detection of glucose glucose transmembrane transporter activity|receptor activity|glucose binding integral to membrane|plasma membrane
YKL040C YKL040C NFU1 hom Verified 0.297264328111085 0.383132356691816 no 1730 0.370106381073545 1235 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS|COFACTOR METABOLISM MITOCHONDRION Protein involved in iron metabolism in mitochondria; similar to NifU, which is a protein required for the maturation of the Fe/S clusters of nitrogenase in nitrogen-fixing bacteria cellular iron ion homeostasis|iron-sulfur cluster assembly|intracellular sequestering of iron ion molecular_function mitochondrion|mitochondrial matrix
YDR347W YDR347W MRP1 hom Verified 0.296770984044919 0.38332067968681 no 1731 0.389722442812314 1286 NA FT TRANSLATION|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the small subunit; MRP1 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator, and with PET123, encoding a small subunit mitochondrial ribosomal protein mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial small ribosomal subunit
YOR010C YOR010C TIR2 hom Verified 0.296294729162402 0.383502505429204 no 1732 0.361699260303897 1231 NA Putative cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; transcription is induced by cold shock and anaerobiosis response to stress molecular_function fungal-type cell wall
YGR226C_d YGR226C YGR226C hom Dubious 0.295155618628288 0.383937501819044 no 1733 0.387653682064392 1285 NA Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; overlaps significantly with a verified ORF, AMA1/YGR225W Unknown Unknown Unknown
YGL080W YGL080W FMP37 hom Verified 0.294549508020177 0.384169019194533 no 1734 0.384451605217476 1274 NA FT MITOCHONDRION Highly conserved subunit of the mitochondrial pyruvate carrier; a mitochondrial inner membrane complex comprised of Fmp37p/Mpc1p and either Mpc2p or Fmp43p/Mpc3p mediates mitochondrial pyruvate uptake; null mutant displays slow growth that is complemented by expression of human or mouse ortholog; mutation in human ortholog is associated with lactic acidosis and hyperpyruvatemia mitochondrial pyruvate transport pyruvate transmembrane transporter activity mitochondrion|integral to mitochondrial inner membrane
YBR217W YBR217W ATG12 hom Verified 0.294423356270664 0.384217210849872 no 1735 0.379245166209188 1257 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS Conserved ubiquitin-like modifier involved in autophagy and the Cvt pathway; conjugated to Atg5p to form a complex involved in Atg8p lipidation; Atg12p-Atg5p also forms a complex with Atg16p that is required for autophagosome formation C-terminal protein lipidation|piecemeal microautophagy of nucleus|mitochondrion degradation|CVT pathway|autophagic vacuole assembly Atg8 ligase activity|protein tag Atg12-Atg5-Atg16 complex|pre-autophagosomal structure
YKL205W YKL205W LOS1 hom Verified 0.293404606127061 0.384606452562017 no 1736 0.39556049382012 1305 NA FT RNA PROCESSING|RNA LOCALIZATION NUCLEUS|MITOCHONDRION Nuclear pore protein involved in nuclear export of pre-tRNA and in re-export of mature tRNAs after their retrograde import from the cytoplasm tRNA re-export from nucleus|tRNA splicing, via endonucleolytic cleavage and ligation|tRNA export from nucleus tRNA binding|Ran GTPase binding mitochondrion|integral to membrane|nuclear matrix|cytoplasm
YOR178C YOR178C GAC1 hom Verified 0.293378453810944 0.384616446312329 no 1737 0.387797682676737 1278 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY Regulatory subunit for Glc7p type-1 protein phosphatase (PP1), tethers Glc7p to Gsy2p glycogen synthase, binds Hsf1p heat shock transcription factor, required for induction of some HSF-regulated genes under heat shock meiosis|glycogen metabolic process|negative regulation of transcription from RNA polymerase II promoter|response to heat|mitotic cell cycle spindle assembly checkpoint protein phosphatase type 1 regulator activity|structural molecule activity|heat shock protein binding protein phosphatase type 1 complex
YLR014C YLR014C PPR1 hom Verified 0.293195283510697 0.384686444489017 no 1738 0.40834323002272 1341 NA FT TRANSCRIPTION FROM RNA POL II|NUCLEOTIDE METABOLISM NUCLEUS Zinc finger transcription factor containing a Zn(2)-Cys(6) binuclear cluster domain, positively regulates transcription of URA1, URA3, URA4, and URA10, which are involved in de novo pyrimidine biosynthesis, in response to pyrimidine starvation; activity may be modulated by interaction with Tup1p positive regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding RNA polymerase II transcription factor activity|sequence-specific DNA binding|zinc ion binding nucleus
YDR363W-A YDR363W-A SEM1 hom Verified 0.291601085356869 0.385295822744923 no 1739 0.398798267857356 1327 NA FT VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|PROTEOLYSIS|RNA LOCALIZATION NUCLEUS Component of lid subcomplex of the 26S proteasome regulatory subunit; involved in mRNA export mediated by the TREX-2 complex (Sac3p-Thp1p); ortholog of human DSS1; protein abundance increases in response to DNA replication stress proteasome assembly|proteasomal ubiquitin-dependent protein catabolic process|regulation of cell cycle|mRNA export from nucleus|exocytosis|filamentous growth|ubiquitin-dependent protein catabolic process molecular_function cytosol|nucleus|proteasome storage granule|proteasome regulatory particle, lid subcomplex
YDR178W YDR178W SDH4 hom Verified 0.291442942147453 0.385356288062339 no 1740 0.410169224345229 1361 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION Membrane anchor subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain mitochondrial electron transport, succinate to ubiquinone|cellular respiration|tricarboxylic acid cycle succinate dehydrogenase (ubiquinone) activity mitochondrial respiratory chain complex II|mitochondrion
YJL188C_d YJL188C BUD19 hom Dubious 0.290238078229001 0.385817053554163 no 1741 0.343394743883025 1129 NA Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 88% of ORF overlaps the verified gene RPL39; diploid mutant displays a weak budding pattern phenotype in a systematic assay Unknown Unknown Unknown
YPR157W_p YPR157W TDA6 hom Uncharacterized 0.289736754901149 0.386008817729609 no 1742 0.376810250806066 1246 NA FT PROTEIN LOCALIZATION Putative protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation; null mutant is sensitive to expression of the top1-T722A allele biological_process molecular_function cellular_component
YLR063W_p YLR063W YLR063W hom Uncharacterized 0.288645324488645 0.386426403563177 no 1743 0.382035270902275 1243 NA Putative S-adenosylmethionine-dependent methyltransferase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR063W is not an essential gene biological_process S-adenosylmethionine-dependent methyltransferase activity cytoplasm
YHR079C YHR079C IRE1 hom Verified 0.288394628955312 0.386522339319659 no 1744 0.408219900681413 1356 NA FF|FT RNA PROCESSING|SIGNALING|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM Serine-threonine kinase and endoribonuclease; transmembrane protein that mediates the unfolded protein response (UPR) by regulating Hac1p synthesis through HAC1 mRNA splicing; Kar2p binds inactive Ire1p and releases from it upon ER stress endoplasmic reticulum unfolded protein response|fungal-type cell wall organization|inositol metabolic process|protein phosphorylation unfolded protein binding|protein serine/threonine kinase activity|endoribonuclease activity|protein kinase activity|protein homodimerization activity nucleus
YKL073W YKL073W LHS1 hom Verified 0.287284228759753 0.386947348775257 no 1745 0.400715229054851 1311 NA FT PROTEIN LOCALIZATION|NUCLEOTIDE METABOLISM ENDOPLASMIC RETICULUM Molecular chaperone of the endoplasmic reticulum lumen, involved in polypeptide translocation and folding; nucleotide exchange factor for the ER lumenal Hsp70 chaperone Kar2p; regulated by the unfolded protein response pathway posttranslational protein targeting to membrane, translocation|response to unfolded protein unfolded protein binding|adenyl-nucleotide exchange factor activity|ATP binding endoplasmic reticulum lumen
YKL184W YKL184W SPE1 hom Verified 0.283917197085479 0.388236918604099 no 1746 0.391881495374528 1307 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM Ornithine decarboxylase, catalyzes the first step in polyamine biosynthesis; degraded in a proteasome-dependent manner in the presence of excess polyamines; deletion decreases lifespan, and increases necrotic cell death and ROS generation pantothenate biosynthetic process|putrescine biosynthetic process ornithine decarboxylase activity cytoplasm
YDR492W YDR492W IZH1 hom Verified 0.281417112590452 0.389195247156023 no 1747 0.386356883128126 1300 NA FT LIPID METABOLISM|ION HOMEOSTASIS|ION HOMEOSTASIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family; transcription is regulated directly by Zap1p, expression induced by zinc deficiency and fatty acids; deletion increases sensitivity to elevated zinc response to zinc ion|cellular zinc ion homeostasis|cellular lipid metabolic process metal ion binding integral to membrane|endoplasmic reticulum|membrane
YJR107W_p YJR107W YJR107W hom Uncharacterized 0.279559693254905 0.389907667288835 no 1748 0.379365484121489 1260 NA FT LIPID METABOLISM Putative lipase biological_process lipase activity cellular_component
YLR429W YLR429W CRN1 hom Verified 0.278969846487272 0.390133982741633 no 1749 0.388367571087382 1294 NA FT CYTOSKELETON ORGANIZATION CYTOSKELETON Coronin, cortical actin cytoskeletal component that associates with the Arp2p/Arp3p complex to regulate its activity; plays a role in regulation of actin patch assembly microtubule-based process|actin filament organization|actin cortical patch localization|Unknown|negative regulation of Arp2/3 complex-mediated actin nucleation microtubule binding|actin filament binding|protein binding, bridging Arp2/3 protein complex|actin cortical patch
YOL162W_p YOL162W YOL162W hom Uncharacterized 0.277746051885431 0.390603653284051 no 1750 0.383969635348486 1276 NA Putative protein of unknown function; member of the Dal5p subfamily of the major facilitator family transmembrane transport transmembrane transporter activity integral to membrane|membrane
YKL041W YKL041W VPS24 hom Verified 0.277606015048612 0.390657407117496 no 1751 0.40374118237525 1329 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|PROTEOLYSIS|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); forms an ESCRT-III subcomplex with Did4p; involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway intralumenal vesicle formation|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|late endosome to vacuole transport molecular_function ESCRT III complex|cytoplasm
YJL176C YJL176C SWI3 hom Verified 0.277252018655082 0.390793299702511 no 1752 0.403527822935383 1359 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS NUCLEUS RSC COMPLEX Subunit of the SWI/SNF chromatin remodeling complex; SWI/SNF regulates transcription by remodeling chromosomes; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2; relocates to the cytosol under hypoxic conditions cellular alcohol catabolic process|ATP-dependent chromatin remodeling|positive regulation of mating type switching|sucrose catabolic process|carbon catabolite activation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter histone binding|DNA binding SWI/SNF complex|nucleus
YPR064W_d YPR064W YPR064W hom Dubious 0.277061963734051 0.390866263730686 no 1753 0.380503063297723 1279 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YPL111W YPL111W CAR1 hom Verified 0.276808060292873 0.390963745853532 no 1754 0.401672940832552 1326 NA FT KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS|SITE OF POLARIZED GROWTH Arginase, responsible for arginine degradation, expression responds to both induction by arginine and nitrogen catabolite repression; disruption enhances freeze tolerance regulation of ornithine metabolic process|arginine catabolic process to ornithine manganese ion binding|arginase activity|ornithine carbamoyltransferase inhibitor activity|zinc ion binding cytosol|nucleus|mating projection tip|cytoplasm
YGR122C-A_d YGR122C-A YGR122C-A hom Dubious 0.27664352444031 0.391026920393972 no 1755 0.389397276318396 1277 NA Dubious open reading frame unlikely to encode a functional protein, similar to YLR334C and YOL106W Unknown Unknown Unknown
YER033C YER033C ZRG8 hom Verified 0.275762171806662 0.391365370011641 no 1756 0.394136057245118 1291 NA FT CELL WALL ORG/BIOGENESIS MITOCHONDRION|SITE OF POLARIZED GROWTH Protein of unknown function; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; GFP-fusion protein is localized to the cytoplasm; transcription induced under conditions of zinc deficiency fungal-type cell wall organization molecular_function mitochondrion|cellular bud|cellular bud neck|mating projection tip|cytoplasm
YGL170C YGL170C SPO74 hom Verified 0.275558234011769 0.391443696215895 no 1757 0.392560549233491 1293 NA FT NUCLEUS|CYTOSKELETON Component of the meiotic outer plaque of the spindle pole body, involved in modifying the meiotic outer plaque that is required prior to prospore membrane formation ascospore formation structural molecule activity spindle pole body
YGR189C YGR189C CRH1 hom Verified 0.273666783539861 0.392170353222348 no 1758 0.384216470527697 1292 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM Chitin transglycosylase that functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar and functionally redundant to Utr2; localizes to sites of polarized growth; expression induced by cell wall stress fungal-type cell wall organization|cell wall chitin metabolic process transferase activity, transferring glycosyl groups incipient cellular bud site|fungal-type cell wall
YFR040W YFR040W SAP155 hom Verified 0.273452663330436 0.392252637626313 no 1759 0.397564688328307 1318 NA FT CELL CYCLE Protein required for function of the Sit4p protein phosphatase; forms a complex with Sit4p; member of a family of similar proteins including Sap4p, Sap185p, and Sap190p; protein abundance increases in response to DNA replication stress G1/S transition of mitotic cell cycle protein serine/threonine phosphatase activity cytoplasm
YBR151W YBR151W APD1 hom Verified 0.272788988820513 0.392507712159737 no 1760 0.389236386736507 1290 NA FT NUCLEUS Protein of unknown function, required for normal localization of actin patches and for normal tolerance of sodium ions and hydrogen peroxide; localizes to both cytoplasm and nucleus biological_process molecular_function nucleus|cytoplasm
YOR351C YOR351C MEK1 hom Verified 0.27260054296098 0.392580147260281 no 1761 0.392737131196248 1307 NA FT CELL CYCLE|PROTEIN PHOSPHORYLATION NUCLEUS Meiosis-specific serine/threonine protein kinase, functions in meiotic checkpoint, promotes recombination between homologous chromosomes by suppressing double strand break repair between sister chromatids meiosis|meiotic recombination checkpoint|protein phosphorylation protein serine/threonine kinase activity|protein kinase activity nucleus
YNL083W YNL083W SAL1 hom Verified 0.27231038833943 0.392691684601295 no 1762 0.382462174497531 1291 NA FT MITOCHONDRION ADP/ATP transporter; member of the Ca2+-binding subfamily of mitochondrial carriers, with two EF-hand motifs; transport activity of either Sal1p or Pet9p is critical for viability; polymorphic in different S. cerevisiae strains ATP transport|ADP transport|mitochondrial transport ATP:ADP antiporter activity|calcium ion binding mitochondrion|integral to membrane|mitochondrial inner membrane
YPL021W YPL021W ECM23 hom Verified 0.271837007444676 0.392873674238743 no 1763 0.370933421422741 1228 NA FT CELL WALL ORG/BIOGENESIS Non-essential protein of unconfirmed function; affects pre-rRNA processing, may act as a negative regulator of the transcription of genes involved in pseudohyphal growth; homologous to Srd1p pseudohyphal growth sequence-specific DNA binding cellular_component
YDR221W YDR221W GTB1 hom Verified 0.271352693518342 0.393059891279818 no 1764 0.387409773136594 1276 NA FT CARBOHYDRATE METABOLISM ENDOPLASMIC RETICULUM Glucosidase II beta subunit, forms a complex with alpha subunit Rot2p; involved in removal of two glucose residues from N-linked glycans during glycoprotein biogenesis in the ER; relocalizes from ER to cytoplasm upon DNA replication stress polysaccharide biosynthetic process|protein N-linked glycosylation alpha-glucosidase activity glucosidase II complex|endoplasmic reticulum|endoplasmic reticulum lumen
YJL101C YJL101C GSH1 hom Verified 0.271176320034616 0.393127712359917 no 1765 0.384211861747128 1258 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|RESPONSE TO OXIDATIVE STRESS Gamma glutamylcysteine synthetase; catalyzes the first step in glutathione (GSH) biosynthesis; expression induced by oxidants, cadmium, and mercury; protein abundance increases in response to DNA replication stress response to cadmium ion|response to hydrogen peroxide|glutathione biosynthetic process glutamate-cysteine ligase activity intracellular
YDL044C YDL044C MTF2 hom Verified 0.269946673488375 0.393600639667504 no 1766 0.405955915756343 1314 NA FT RNA PROCESSING|TRANSLATION MITOCHONDRION Mitochondrial matrix protein that interacts with an N-terminal region of mitochondrial RNA polymerase (Rpo41p) and couples RNA processing and translation to transcription cytoplasmic translation|mRNA processing RNA binding mitochondrion
YLR044C YLR044C PDC1 hom Verified 0.269766374648117 0.393669996585156 no 1767 0.402097364933362 1327 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY NUCLEUS Major of three pyruvate decarboxylase isozymes, key enzyme in alcoholic fermentation, decarboxylates pyruvate to acetaldehyde; subject to glucose-, ethanol-, and autoregulation; involved in amino acid catabolism L-phenylalanine catabolic process|pyruvate metabolic process|glucose catabolic process to ethanol|tryptophan catabolic process|aromatic amino acid family catabolic process to alcohol via Ehrlich pathway pyruvate decarboxylase activity cytosol|nucleus|cytoplasm
YOR343C_d YOR343C YOR343C hom Dubious 0.268890666204571 0.394006909916326 no 1768 0.386444395519681 1260 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YDL118W_d YDL118W YDL118W hom Dubious 0.268635163059482 0.394105225193735 no 1769 0.412033804468638 1368 NA FF|FT ION HOMEOSTASIS|ION HOMEOSTASIS Dubious open reading frame, unlikely to encode a protein; overlaps almost completely with YDL119C; mutations that would affect both YDL118W and YDL119C confer defective telomere maintenance and are synthetically sick or lethal with alpha-synuclein biological_process molecular_function cellular_component
YPL003W YPL003W ULA1 hom Verified 0.26790867372308 0.394384808510442 no 1770 0.39698148814558 1308 NA Protein that acts together with Uba3p to activate Rub1p before its conjugation to proteins (neddylation), which may play a role in protein degradation protein neddylation NEDD8 activating enzyme activity cellular_component
YDL224C YDL224C WHI4 hom Verified 0.267732420815283 0.394452646169394 no 1771 0.358649588481744 1173 NA Putative RNA binding protein; regulates the cell size requirement for passage through Start and commitment to cell division; WHI4 has a paralog, WHI3, that arose from the whole genome duplication regulation of cell size RNA binding cytoplasm
YIL123W YIL123W SIM1 hom Verified 0.26718058569526 0.394665061671151 no 1772 0.39512390104638 1323 NA FT CELL WALL ORG/BIOGENESIS Protein of the SUN family (Sim1p, Uth1p, Nca3p, Sun4p) that may participate in DNA replication, promoter contains SCB regulation box at -300 bp indicating that expression may be cell cycle-regulated fungal-type cell wall organization molecular_function fungal-type cell wall
YIL017C YIL017C VID28 hom Verified 0.267001410222769 0.394734037648104 no 1773 0.384527510703778 1281 NA FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|CARBOHYDRATE METABOLISM|PROTEOLYSIS NUCLEUS GID Complex subunit, serves as adaptor for regulatory subunit Vid24p; protein involved in proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBPase); localized to the nucleus and the cytoplasm negative regulation of gluconeogenesis|proteasomal ubiquitin-dependent protein catabolic process|vacuolar protein catabolic process|ascospore formation|positive regulation of transcription from RNA polymerase II promoter molecular_function nucleus|GID complex|cytoplasm
YDL051W YDL051W LHP1 hom Verified 0.266939337472738 0.394757934147063 no 1774 0.396184043055953 1290 NA FT RNA PROCESSING NUCLEUS RNA binding protein required for maturation of tRNA and U6 snRNA precursors; acts as a molecular chaperone for RNAs transcribed by polymerase III; homologous to human La (SS-B) autoantigen tRNA processing RNA binding|tRNA binding nucleoplasm|nucleolus|nucleus
YIR014W_p YIR014W YIR014W hom Uncharacterized 0.266674964114588 0.394859715893068 no 1775 0.381665201125377 1266 NA Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p; YIR014W is a non-essential gene biological_process molecular_function fungal-type vacuole
YGL045W YGL045W RIM8 hom Verified 0.265783033491151 0.39520315535226 no 1776 0.410861470320162 1338 NA FF|FT VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE Protein involved in proteolytic activation of Rim101p in response to alkaline pH; interacts with ESCRT-1 subunits Stp22p and Vps28p; essential for anaerobic growth; member of the arrestin-related trafficking adaptor family meiosis|protein processing|invasive growth in response to glucose limitation|ubiquitin-dependent endocytosis molecular_function internal side of plasma membrane
YIL124W YIL124W AYR1 hom Verified 0.26518609335239 0.395433053704527 no 1777 0.39728420231439 1306 NA FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS ENDOPLASMIC RETICULUM|MITOCHONDRION NADPH-dependent 1-acyl dihydroxyacetone phosphate reductase found in lipid particles, ER, and mitochondrial outer membrane; involved in phosphatidic acid biosynthesis; required for spore germination; capable of metabolizing steroid hormones phosphatidic acid biosynthetic process acylglycerone-phosphate reductase activity mitochondrial outer membrane|mitochondrion|integral to membrane|endoplasmic reticulum|lipid particle|cytoplasm
YDR163W YDR163W CWC15 hom Verified 0.264577003716543 0.395667668682104 no 1778 0.406458310734262 1321 NA FT RNA PROCESSING NUCLEUS Non-essential protein involved in pre-mRNA splicing, component of a complex containing Cef1p; has similarity to S. pombe Cwf15p mRNA splicing, via spliceosome molecular_function U2-type spliceosomal complex
YDR411C YDR411C DFM1 hom Verified 0.264247169048837 0.395794733344401 no 1779 0.384841844109379 1258 NA FT SIGNALING|PROTEOLYSIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM UBIQUITIN LIGASE COMPLEX Endoplasmic reticulum (ER) localized protein involved in ER-associated protein degradation (ERAD), ER stress and homeostasis; interacts with components of ERAD-L and ERAD-C and Cdc48p; derlin-like family member similar to Der1p endoplasmic reticulum unfolded protein response|ER-associated protein catabolic process molecular_function Doa10p ubiquitin ligase complex|integral to membrane|endoplasmic reticulum|Hrd1p ubiquitin ligase ERAD-L complex
YOR115C YOR115C TRS33 hom Verified 0.263957550822647 0.395906314260157 no 1780 0.391192616268158 1309 NA FT VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS ENDOPLASMIC RETICULUM|GOLGI APPARATUS One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic ER to Golgi vesicle-mediated transport|protein complex assembly molecular_function trans-Golgi network|TRAPP complex|cis-Golgi network
YFL040W_p YFL040W YFL040W hom Uncharacterized 0.263605147100169 0.396042095983257 no 1781 0.39684474452291 1297 NA Putative transporter, member of the sugar porter family; YFL040W is not an essential gene transmembrane transport substrate-specific transmembrane transporter activity integral to membrane|membrane
YKL168C YKL168C KKQ8 hom Verified 0.263373831706377 0.396131229036141 no 1782 0.391530867341304 1303 NA FT PROTEIN PHOSPHORYLATION Putative serine/threonine protein kinase with unknown cellular role; KKQ8 has a paralog, HAL5, that arose from the whole genome duplication biological_process protein kinase activity cytoplasm
YDR147W YDR147W EKI1 hom Verified 0.262163138867777 0.396597835326197 no 1783 0.410011312296386 1372 NA FT LIPID METABOLISM Ethanolamine kinase; primarily responsible for phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway; exhibits some choline kinase activity, thus contributing to phosphatidylcholine synthesis via the CDP-choline pathway; EKI1 has a paralog, CKI1, that arose from the whole genome duplication phosphatidylethanolamine biosynthetic process|phosphatidylcholine biosynthetic process ethanolamine kinase activity|choline kinase activity cytoplasm
YER031C YER031C YPT31 hom Verified 0.261899759743103 0.396699362426077 no 1784 0.430649391931638 1404 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING ENDOMEMBRANE SYSTEM|MITOCHONDRION|GOLGI APPARATUS Rab family GTPase; involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; YPT31 has a paralog, YPT32, that arose from the whole genome duplication early endosome to Golgi transport|vesicle-mediated transport|exocytosis GTPase activity mitochondrial outer membrane|endosome|Golgi apparatus
YKR058W YKR058W GLG1 hom Verified 0.260513692299324 0.397233777460257 no 1785 0.393711886121188 1309 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY Glycogenin glucosyltransferase; self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; similar to mammalian glycogenin; GLG1 has a paralog, GLG2, that arose from the whole genome duplication glycogen biosynthetic process glycogenin glucosyltransferase activity cellular_component
YDR279W YDR279W RNH202 hom Verified 0.260481786912586 0.397246081243421 no 1786 0.381938589380027 1282 NA FT NUCLEUS Ribonuclease H2 subunit, required for RNase H2 activity; related to human AGS2 that causes Aicardi-Goutieres syndrome RNA catabolic process|DNA replication, removal of RNA primer ribonuclease H activity ribonuclease H2 complex|nucleus
YGL261C_p YGL261C PAU11 hom Uncharacterized 0.259880926327694 0.397477812244151 no 1787 0.400540181928909 1323 NA Putative protein of unknown function and member of the seripauperin multigene family encoded mainly in subtelomeric regions; mRNA expression appears to be regulated by SUT1 and UPC2 biological_process molecular_function cellular_component
YKR102W YKR102W FLO10 hom Verified 0.259647559416388 0.397567823495307 no 1788 0.391163006591308 1301 NA Member of the FLO family of cell wall flocculation proteins; not expressed in most lab strains; overproduction induces flocculation that can be inhibited by mannose, sucrose, or glucose; overproduction also promotes haploid invasive growth and diploid filamentous growth filamentous growth of a population of unicellular organisms|flocculation via cell wall protein-carbohydrate interaction|flocculation|invasive growth in response to glucose limitation mannose binding fungal-type cell wall
YFL032W_d YFL032W YFL032W hom Dubious 0.259645778797476 0.397568510313457 no 1789 0.403542163906579 1339 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene HAC1/YFL031W; YFL032W is not an essential gene Unknown Unknown Unknown
YLR423C YLR423C ATG17 hom Verified 0.259458017152841 0.397640935287286 no 1790 0.410228877039212 1344 NA FT MEMBRANE ORGANIZATION|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS|PEROXISOME ORGANIZATION Scaffold protein responsible for phagophore assembly site organization; regulatory subunit of an autophagy-specific complex that includes Atg1p and Atg13p; stimulates Atg1p kinase activity; human ortholog RB1CC1/FIP200 interacts with p53, which inhibits autophagy in human cells piecemeal microautophagy of nucleus|mitochondrion degradation|peroxisome degradation|activation of protein kinase activity|autophagic vacuole assembly protein kinase activator activity|protein complex scaffold pre-autophagosomal structure|Atg1p signaling complex
YDR345C YDR345C HXT3 hom Verified 0.259350735894902 0.397682318285103 no 1791 0.42356581533473 1402 NA FT PLASMA MEMBRANE Low affinity glucose transporter of the major facilitator superfamily; expression is induced in low or high glucose conditions; HXT3 has a paralog, HXT5, that arose from the whole genome duplication hexose transport|transmembrane transport mannose transmembrane transporter activity|fructose transmembrane transporter activity|glucose transmembrane transporter activity integral to membrane|plasma membrane
YOL087C YOL087C DUF1 hom Verified 0.25909859047628 0.397779586156231 no 1792 0.449446871661668 1473 NA Ubiquitin-binding protein of unknown function; contains one WD40 repeat in a beta-propeller fold; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; homolog of human WDR48/UAF1, which is involved in regulating the Fanconi anemia pathway; deletion mutant is sensitive to various chemicals including phenanthroline, sanguinarine, and nordihydroguaiaretic acid biological_process ubiquitin binding cytoplasm
YNL274C YNL274C GOR1 hom Verified 0.258370620024327 0.39806044441015 no 1793 0.389887605535225 1279 NA FT KETONE METABOLISM|OXIDATION-REDUCTION PROCESS NUCLEUS|MITOCHONDRION Glyoxylate reductase; null mutation results in increased biomass after diauxic shift; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress glyoxylate catabolic process|metabolic process oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|glyoxylate reductase activity mitochondrion|nucleus|cytoplasm
YMR316W YMR316W DIA1 hom Verified 0.258149478030492 0.39814577366327 no 1794 0.412761441184056 1373 NA Protein of unknown function, involved in invasive and pseudohyphal growth; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern pseudohyphal growth|invasive growth in response to glucose limitation molecular_function cytoplasm
YGR044C YGR044C RME1 hom Verified 0.257766158044103 0.398293692016933 no 1795 0.362451954817982 1173 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CELL DIVISION NUCLEUS Zinc finger protein involved in control of meiosis; prevents meiosis by repressing IME1 expression and promotes mitosis by activating CLN2 expression; directly repressed by a1-alpha2 regulator; mediates cell type control of sporulation; relocalizes from nucleus to cytoplasm upon DNA replication stress negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription during meiosis|negative regulation of meiosis|positive regulation of invasive growth in response to glucose limitation by positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription involved in G1/S phase of mitotic cell cycle|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity nucleus
YLL032C YLL032C YLL032C hom Verified 0.255389623010311 0.399211092379807 no 1796 0.389529080280777 1310 NA Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene biological_process molecular_function ribosome|cytoplasm
YMR205C YMR205C PFK2 hom Verified 0.254926752591497 0.399389836582756 no 1797 0.476097532761484 1794 NA FT CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Beta subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes proton transport|glycolysis mRNA binding|6-phosphofructokinase activity mitochondrion|6-phosphofructokinase complex|cytoplasm
YIL079C YIL079C AIR1 hom Verified 0.254550209738622 0.399535259689975 no 1798 0.396010996943835 1304 NA FT RNA PROCESSING NUCLEUS Zinc knuckle protein; involved in nuclear RNA processing and degradation as a component of the TRAMP complex; stimulates the poly(A) polymerase activity of Pap2p in vitro; AIR1 has a paralog, AIR2, that arose from the whole genome duplication nuclear mRNA surveillance of mRNA 3'-end processing|nuclear polyadenylation-dependent tRNA catabolic process|nuclear polyadenylation-dependent CUT catabolic process|nuclear polyadenylation-dependent snoRNA catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|ncRNA polyadenylation|nuclear polyadenylation-dependent snRNA catabolic process polynucleotide adenylyltransferase activity nucleolus|TRAMP complex
YPR062W YPR062W FCY1 hom Verified 0.253815298280177 0.399819127035774 no 1799 0.41067919248321 1325 NA FT NUCLEUS Cytosine deaminase, zinc metalloenzyme that catalyzes the hydrolytic deamination of cytosine to uracil; of biomedical interest because it also catalyzes the deamination of 5-fluorocytosine (5FC) to form anticancer drug 5-fluorouracil (5FU) cytosine metabolic process|pyrimidine-containing compound salvage|cytidine metabolic process cytosine deaminase activity nucleus|cytoplasm
YOL001W YOL001W PHO80 hom Verified 0.252408872338238 0.400362521493771 no 1800 0.415409435195536 1383 NA FF|FT PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|CELL CYCLE|SIGNALING|ION HOMEOSTASIS|PROTEIN PHOSPHORYLATION|ION HOMEOSTASIS|RESPONSE TO NUTRIENT LEVELS NUCLEUS Cyclin, interacts with cyclin-dependent kinase Pho85p; regulates the response to nutrient levels and environmental conditions, including the response to phosphate limitation and stress-dependent calcium signaling negative regulation of phosphate metabolic process|regulation of cyclin-dependent protein kinase activity|negative regulation of calcium-mediated signaling|negative regulation of transcription from RNA polymerase II promoter|cellular metal ion homeostasis|regulation of protein localization|negative regulation of macroautophagy cyclin-dependent protein kinase regulator activity cyclin-dependent protein kinase holoenzyme complex|nucleus
YBR250W YBR250W SPO23 hom Verified 0.25198350974994 0.400526904967776 no 1801 0.403814290419953 1331 NA FT CELL CYCLE Protein of unknown function; associates with meiosis-specific protein Spo1p meiosis molecular_function cellular_component
YOR245C YOR245C DGA1 hom Verified 0.251756203339018 0.400614755879046 no 1802 0.40824015575418 1359 NA FT LIPID METABOLISM|CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Diacylglycerol acyltransferase, catalyzes the terminal step of triacylglycerol (TAG) formation, acylates diacylglycerol using acyl-CoA as an acyl donor, localized to lipid particles lipid storage|triglyceride biosynthetic process diacylglycerol O-acyltransferase activity integral to membrane|lipid particle
YBL091C YBL091C MAP2 hom Verified 0.251430177421209 0.400740769345342 no 1803 0.403453519439364 1339 NA FT PROTEOLYSIS Methionine aminopeptidase, catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map1p protein initiator methionine removal involved in protein maturation metalloaminopeptidase activity cytoplasm
YBR282W YBR282W MRPL27 hom Verified 0.250496437749492 0.401101729586577 no 1804 0.401105291197759 1347 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit; homolog of human Bcl-2 interacting protein BMRP mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YPR058W YPR058W YMC1 hom Verified 0.250477108761155 0.401109202579743 no 1805 0.400046975492421 1301 NA FT MITOCHONDRION Putative mitochondrial inner membrane transporter; proposed role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; YMC1 has a paralog, YMC2, that arose from the whole genome duplication mitochondrial transport organic acid transmembrane transporter activity mitochondrion|integral to membrane
YBR040W YBR040W FIG1 hom Verified 0.249694526023799 0.401411795872674 no 1806 0.395922547686571 1331 NA FT SITE OF POLARIZED GROWTH Integral membrane protein required for efficient mating; may participate in or regulate the low affinity Ca2+ influx system, which affects intracellular signaling and cell-cell fusion during mating cell morphogenesis involved in conjugation with cellular fusion|cytogamy molecular_function fungal-type cell wall|integral to membrane|mating projection tip
YKL025C YKL025C PAN3 hom Verified 0.249650377704082 0.401428868017333 no 1807 0.427541717245081 1418 NA FT RNA PROCESSING|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes DNA repair|mRNA 3'-end processing|postreplication repair poly(A)-specific ribonuclease activity PAN complex|cytoplasm
YLR216C YLR216C CPR6 hom Verified 0.249610671211195 0.40144422266934 no 1808 0.377280620356514 1231 NA Peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity; protein abundance increases in response to DNA replication stress protein folding|protein refolding unfolded protein binding|peptidyl-prolyl cis-trans isomerase activity cytoplasm
YNL125C YNL125C ESBP6 hom Verified 0.249436717197094 0.401511493142525 no 1809 0.39971322471895 1301 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION Protein with similarity to monocarboxylate permeases, appears not to be involved in transport of monocarboxylates such as lactate, pyruvate or acetate across the plasma membrane transport monocarboxylic acid transmembrane transporter activity|transporter activity mitochondrion|integral to membrane|endoplasmic reticulum|membrane
YOL045W YOL045W PSK2 hom Verified 0.248657397741132 0.401812902782938 no 1810 0.412897170956254 1353 NA FT SIGNALING|TRANSLATION|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION PAS-domain containing serine/threonine protein kinase; regulates sugar flux and translation in response to an unknown metabolite by phosphorylating Ugp1p and Gsy2p (sugar flux) and Caf20p, Tif11p and Sro9p (translation); PSK2 has a paralog, PSK1, that arose from the whole genome duplication regulation of (1->6)-beta-D-glucan biosynthetic process|negative regulation of glycogen biosynthetic process|protein phosphorylation protein serine/threonine kinase activity mitochondrion|cytoplasm
YOL119C YOL119C MCH4 hom Verified 0.245398696682297 0.403073869031541 no 1811 0.382228053407975 1247 NA Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport transport monocarboxylic acid transmembrane transporter activity|transporter activity fungal-type vacuole membrane|integral to membrane
YPR063C_p YPR063C YPR063C hom Uncharacterized 0.245325705846661 0.403102124699007 no 1812 0.403716607362243 1338 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM ER-localized protein of unknown function biological_process molecular_function endoplasmic reticulum
YER093C-A YER093C-A AIM11 hom Verified 0.24480205158859 0.403304852654071 no 1813 0.405018316387595 1339 NA Protein of unknown function; null mutant is viable but shows increased loss of mitochondrial genome and synthetic interaction with prohibitin (phb1); contains an intron; YER093C-A has a paralog, YBL059W, that arose from the whole genome duplication biological_process molecular_function cellular_component
YAL028W YAL028W FRT2 hom Verified 0.243487795007975 0.403813769417792 no 1814 0.373973729943427 1263 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Tail-anchored ER membrane protein of unknown function; interacts with homolog Frt1p; promotes growth in conditions of high Na+, alkaline pH, or cell wall stress, possibly via a role in posttranslational translocation; potential Cdc28p substrate; FRT2 has a paralog, FRT1, that arose from the whole genome duplication response to stress molecular_function endoplasmic reticulum
YDR008C_d YDR008C YDR008C hom Dubious 0.242612737278538 0.404152706530359 no 1815 0.46759946182546 1546 NA FF Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YDL137W YDL137W ARF2 hom Verified 0.242384530910804 0.404241109804982 no 1816 0.407529373094024 1346 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING|RESPONSE TO NUTRIENT LEVELS GOLGI APPARATUS ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated formation vesicles in intracellular trafficking within the Golgi; ARF2 has a paralog, ARF1, that arose from the whole genome duplication ER to Golgi vesicle-mediated transport|macroautophagy|intra-Golgi vesicle-mediated transport GTPase activity cytosol|Golgi-associated vesicle
YGR230W YGR230W BNS1 hom Verified 0.241329899458358 0.404649719585027 no 1817 0.396548394096657 1321 NA FT CELL CYCLE Protein with some similarity to Spo12p; overexpression bypasses need for Spo12p, but not required for meiosis meiosis molecular_function cellular_component
YDR386W YDR386W MUS81 hom Verified 0.241005958400275 0.404775249244041 no 1818 0.451965635751368 1507 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION NUCLEUS Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in DNA repair, replication fork stability, and joint molecule formation/resolution during meiotic recombination; helix-hairpin-helix protein; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates the function of Mms4p-Mus81p DNA repair|DNA topological change|reciprocal meiotic recombination|resolution of meiotic recombination intermediates|response to DNA damage stimulus crossover junction endodeoxyribonuclease activity|endonuclease activity Holliday junction resolvase complex|nucleus
YOL100W YOL100W PKH2 hom Verified 0.24060856041275 0.404929257414896 no 1819 0.392698290082761 1289 NA FT VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|RNA PROCESSING|SIGNALING|CELL WALL ORG/BIOGENESIS|PROTEIN PHOSPHORYLATION NUCLEUS Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; redundant with Pkh1p regulation of nuclear-transcribed mRNA poly(A) tail shortening|protein phosphorylation|MAPK cascade involved in cell wall biogenesis|cytoplasmic mRNA processing body assembly protein kinase activity cell cortex|eisosome|nucleus
YLR303W YLR303W MET17 hom Verified 0.240184768392155 0.405093510591797 no 1820 0.399081083905616 1313 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Methionine and cysteine synthase (O-acetyl homoserine-O-acetyl serine sulfhydrylase), required for sulfur amino acid synthesis methionine metabolic process|cysteine biosynthetic process O-acetylhomoserine aminocarboxypropyltransferase activity|cysteine synthase activity plasma membrane|cytoplasm
YDR124W_p YDR124W YDR124W hom Uncharacterized 0.239721809960983 0.405272962981882 no 1821 0.395867291335225 1277 NA Putative protein of unknown function; non-essential gene; expression is strongly induced by alpha factor biological_process molecular_function cellular_component
YIL029C_p YIL029C YIL029C hom Uncharacterized 0.238525922749768 0.405736606011743 no 1822 0.412701063848188 1385 NA Putative protein of unknown function; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO); YIL029C has paralog YPR071W biological_process molecular_function integral to membrane
YAL044C YAL044C GCV3 hom Verified 0.238068275908381 0.405914069786603 no 1823 0.425665853204344 1396 NA FT KETONE METABOLISM|AMINO ACID METABOLISM MITOCHONDRION H subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; also required for all protein lipoylation; expression is regulated by levels of 5,10-methylene-THF glycine catabolic process|one-carbon metabolic process|protein lipoylation glycine dehydrogenase (decarboxylating) activity mitochondrion|glycine cleavage complex
YHL026C_p YHL026C YHL026C hom Uncharacterized 0.237651283225875 0.406075785751984 no 1824 0.414509135768522 1356 NA Putative protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; YHL026C is not an essential gene; in 2005 the start site was moved 141 nt upstream (see Locus History) biological_process molecular_function cellular_component
YLR146C YLR146C SPE4 hom Verified 0.237570607564084 0.406107074824852 no 1825 0.401853701650091 1329 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM Spermine synthase, required for the biosynthesis of spermine and also involved in biosynthesis of pantothenic acid pantothenate biosynthetic process|spermine biosynthetic process spermine synthase activity cytoplasm
YPL198W YPL198W RPL7B hom Verified 0.237188163619421 0.406255409207473 no 1826 0.408327665727589 1337 NA FT TRANSLATION NUCLEUS RIBOSOME Ribosomal 60S subunit protein L7B; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2); homologous to mammalian ribosomal protein L7 and bacterial L30; RPL7B has a paralog, RPL7A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit|nucleolus|cytoplasm
YLR449W YLR449W FPR4 hom Verified 0.237088087437848 0.406294226892125 no 1827 0.406007136649417 1321 NA FT CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS|CHROMOSOME Peptidyl-prolyl cis-trans isomerase (PPIase) (proline isomerase) localized to the nucleus; catalyzes isomerization of proline residues in histones H3 and H4, which affects lysine methylation of those histones histone peptidyl-prolyl isomerization|negative regulation of histone H3-K36 methylation|regulation of transcription by chromatin organization|chromatin silencing at rDNA|nucleosome assembly peptidyl-prolyl cis-trans isomerase activity|macrolide binding chromatin|nucleus
YLR342W-A_p YLR342W-A YLR342W-A hom Uncharacterized 0.236495176533429 0.40652422485612 no 1828 0.396956465523388 1327 NA Putative protein of unknown function biological_process molecular_function cellular_component
YJL059W YJL059W YHC3 hom Verified 0.236029071935669 0.406705055627692 no 1829 0.402461840062689 1343 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS|VACUOLAR TRANSPORT Vacuolar membrane protein involved in the ATP-dependent transport of arginine into the vacuole and possibly in balancing ion homeostasis; homolog of human CLN3 involved in Batten disease (juvenile onset neuronal ceroid lipofuscinosis) basic amino acid transport|regulation of intracellular pH|arginine transport molecular_function integral to membrane|fungal-type vacuole
YBR073W YBR073W RDH54 hom Verified 0.23470831984956 0.407217564899493 no 1830 0.440679359782953 1463 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION NUCLEUS DNA-dependent ATPase; stimulates strand exchange by modifying the topology of double-stranded DNA; involved in recombinational repair of DNA double-strand breaks during mitosis and meiosis; proposed to be involved in crossover interference; interacts with Dmc1p; stimulates Dmc1p and Rad51p DNA geometric change|heteroduplex formation|meiotic sister chromatid segregation|reciprocal meiotic recombination|double-strand break repair via break-induced replication DNA-dependent ATPase activity|DNA translocase activity nucleus
YJR094W-A YJR094W-A RPL43B hom Verified 0.233768079835747 0.407582515805835 no 1831 0.392620003343085 1309 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L43B; homologous to mammalian ribosomal protein L37A, no bacterial homolog; RPL43B has a paralog, RPL43A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YGR080W YGR080W TWF1 hom Verified 0.233715887495974 0.407602776434855 no 1832 0.403899741592161 1362 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH|CYTOSKELETON Twinfilin, highly conserved actin monomer-sequestering protein involved in regulation of the cortical actin cytoskeleton, composed of two cofilin-like regions, localizes actin monomers to sites of rapid filament assembly bipolar cellular bud site selection|actin polymerization or depolymerization|sequestering of actin monomers actin monomer binding mating projection tip|actin cortical patch
YBR206W_d YBR206W YBR206W hom Dubious 0.233083316402216 0.407848354867983 no 1833 0.40710907962323 1350 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene KTR3 Unknown Unknown Unknown
YBL038W YBL038W MRPL16 hom Verified 0.232798710889657 0.407958856993989 no 1834 0.422674517525845 1382 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit mitochondrial translation structural constituent of ribosome|peptidyltransferase activity mitochondrion|mitochondrial large ribosomal subunit
YKL066W_d YKL066W YKL066W hom Dubious 0.232497727067378 0.4080757261966 no 1835 0.372461587281224 1243 NA Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene YNK1 Unknown Unknown Unknown
YMR161W YMR161W HLJ1 hom Verified 0.232389828928814 0.408117624026449 no 1836 0.413725390949073 1380 NA FT PROTEOLYSIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Co-chaperone for Hsp40p, anchored in the ER membrane; with its homolog Ydj1p promotes ER-associated protein degradation (ERAD) of integral membrane substrates; similar to E. coli DnaJ ER-associated protein catabolic process ATPase activator activity endoplasmic reticulum|endoplasmic reticulum membrane
YAL037W_p YAL037W YAL037W hom Uncharacterized 0.231540046945919 0.408447638792141 no 1837 0.416368589171219 1355 NA Putative protein of unknown function; YAL037W has a paralog, YOR342C, that arose from the whole genome duplication biological_process molecular_function cellular_component
YBR178W_d YBR178W YBR178W hom Dubious 0.230994322347968 0.408659606437934 no 1838 0.413356471061694 1371 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR177C Unknown Unknown Unknown
YDL151C_d YDL151C BUD30 hom Dubious 0.229946872966623 0.409066526355216 no 1839 0.420639949089941 1378 NA Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 96% of ORF overlaps the verified gene RPC53; diploid mutant displays a weak budding pattern phenotype in a systematic assay Unknown Unknown Unknown
YPL227C YPL227C ALG5 hom Verified 0.22848506364637 0.409634583266868 no 1840 0.412093305636303 1369 NA FT CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM UDP-glucose:dolichyl-phosphate glucosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulum protein N-linked glycosylation dolichyl-phosphate beta-glucosyltransferase activity endoplasmic reticulum membrane
YPL248C YPL248C GAL4 hom Verified 0.227738237400729 0.409924872138828 no 1841 0.401614714941855 1316 NA FT TRANSCRIPTION FROM RNA POL II|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS NUCLEUS DNA-binding transcription factor required for the activation of the GAL genes in response to galactose; repressed by Gal80p and activated by Gal3p galactose metabolic process|positive regulation of transcription from RNA polymerase II promoter by galactose RNA polymerase II transcription factor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity nucleus
YLL060C YLL060C GTT2 hom Verified 0.226934012080044 0.410237527050581 no 1842 0.399738775838335 1325 NA FT KETONE METABOLISM|AMINO ACID METABOLISM MITOCHONDRION Glutathione S-transferase capable of homodimerization; functional overlap with Gtt2p, Grx1p, and Grx2p; protein abundance increases in response to DNA replication stress glutathione metabolic process glutathione transferase activity mitochondrion
YLR371W YLR371W ROM2 hom Verified 0.225630448936046 0.410744428320014 no 1843 0.465177820160686 1535 NA FF|FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING|CELL WALL ORG/BIOGENESIS|NUCLEOTIDE METABOLISM SITE OF POLARIZED GROWTH GDP/GTP exchange factor (GEF) for Rho1p and Rho2p; mutations are synthetically lethal with mutations in rom1, which also encodes a GEF; Rom2p localization to the bud surface is dependent on Ack1p regulation of fungal-type cell wall organization|positive regulation of endocytosis|establishment of cell polarity|small GTPase mediated signal transduction|negative regulation of cAMP-mediated signaling|activation of Rho GTPase activity phosphatidylinositol-4,5-bisphosphate binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity incipient cellular bud site|mating projection tip|cellular bud tip
YPL047W YPL047W SGF11 hom Verified 0.225607619977227 0.410753306879698 no 1844 0.402892675085968 1335 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION NUCLEUS HISTONE ACETYLTRANSFERASE Integral subunit of SAGA histone acetyltransferase complex, regulates transcription of a subset of SAGA-regulated genes, required for the Ubp8p association with SAGA and for H2B deubiquitylation histone deubiquitination|regulation of transcription from RNA polymerase II promoter enzyme activator activity DUBm complex|nucleus|SAGA complex
YAL015C YAL015C NTG1 hom Verified 0.225441807308286 0.410817795541236 no 1845 0.397280764285002 1321 NA FT RESPONSE TO DNA DAMAGE|MITOCHONDRION ORGANIZATION|RESPONSE TO OXIDATIVE STRESS NUCLEUS|MITOCHONDRION DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; NTG1 has a paralog, NTG2, that arose from the whole genome duplication DNA repair|cellular response to oxidative stress|base-excision repair|base-excision repair, AP site formation|positive regulation of mitochondrial DNA replication oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity|oxidized purine nucleobase lesion DNA N-glycosylase activity|DNA-(apurinic or apyrimidinic site) lyase activity mitochondrion|nucleus
YDL095W YDL095W PMT1 hom Verified 0.225330542725645 0.410861070450085 no 1846 0.424757363952334 1427 NA FT PROTEIN LOCALIZATION|CARBOHYDRATE METABOLISM|PROTEOLYSIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Protein O-mannosyltransferase of the ER membrane; transfers mannose from dolichyl phosphate-D-mannose to protein serine and threonine residues; 1 of 7 related proteins involved in O-glycosylation which is essential for cell wall rigidity; involved in ER quality control; amino terminus faces cytoplasm, carboxyl terminus faces ER lumen ER-associated misfolded protein catabolic process|Unknown|protein exit from endoplasmic reticulum|protein O-linked mannosylation dolichyl-phosphate-mannose-protein mannosyltransferase activity integral to membrane|dolichyl-phosphate-mannose-protein mannosyltransferase complex
YMR025W YMR025W CSI1 hom Verified 0.224973935523209 0.410999775481075 no 1847 0.398601048732084 1310 NA FT SIGNALING NUCLEUS Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling; functional equivalent of canonical Csn6 subunit of the COP9 signalosome adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion|cullin deneddylation molecular_function signalosome
YGL100W YGL100W SEH1 hom Verified 0.224560519126389 0.411160590799586 no 1848 0.413005214299921 1373 NA FF|FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RNA LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS|PLASMA MEMBRANE NUCLEAR PORE Component of two distinct complexes; subunit of the Nup84 nuclear pore sub-complex (NPC) and the Seh1-associated (SEA) complex; the the NUP84 subcomplex contributes to nucleocytoplasmic transport and NPC biogenesis; the SEA complex is a coatamer-related complex that associates dynamically with the vacuole; homologous to human SEH1 nucleocytoplasmic transport structural constituent of nuclear pore fungal-type vacuole membrane|integral to membrane|nuclear pore|Seh1-associated complex|nuclear pore outer ring
YCR049C_d YCR049C YCR049C hom Dubious 0.224266629569711 0.411274920316298 no 1849 0.425833498482836 1413 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YIL042C YIL042C PKP1 hom Verified 0.224179208889619 0.411308930342748 no 1850 0.407375956972358 1351 NA FT SIGNALING|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION MITOCHONDRION Mitochondrial protein kinase involved in negative regulation of pyruvate dehydrogenase complex activity by phosphorylating the ser-133 residue of the Pda1p subunit; acts in concert with kinase Pkp2p and phosphatases Ptc5p and Ptc6p peptidyl-serine phosphorylation|protein phosphorylation|carbon utilization protein kinase activity|pyruvate dehydrogenase (acetyl-transferring) kinase activity mitochondrion
YIL097W YIL097W FYV10 hom Verified 0.224011073782353 0.411374343277344 no 1851 0.417630199551379 1384 NA FT KETONE METABOLISM|CARBOHYDRATE METABOLISM|PROTEOLYSIS NUCLEUS Subunit of GID complex; involved in proteasome-dependent catabolite inactivation of gluconeogenic enzymes FBPase, PEPCK, and c-MDH; forms dimer with Rmd5p that is then recruited to GID Complex by Gid8p; contains a degenerate RING finger motif needed for GID complex ubiquitin ligase activity in vivo, as well as CTLH and CRA domains; plays role in anti-apoptosis; required for survival upon exposure to K1 killer toxin negative regulation of gluconeogenesis|proteasomal ubiquitin-dependent protein catabolic process|anti-apoptosis ubiquitin-protein ligase activity nucleus|GID complex|cytoplasm
YJL089W YJL089W SIP4 hom Verified 0.223790231027773 0.411460265856148 no 1852 0.418638823981924 1373 NA FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS NUCLEUS C6 zinc cluster transcriptional activator that binds to the carbon source-responsive element (CSRE) of gluconeogenic genes; involved in the positive regulation of gluconeogenesis; regulated by Snf1p protein kinase; localized to the nucleus positive regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source|positive regulation of gluconeogenesis|positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter|Unknown RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus
YMR105C YMR105C PGM2 hom Verified 0.222974117242971 0.411777825428431 no 1853 0.407945877546468 1336 NA FT ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|ION HOMEOSTASIS|GEN. OF PRECURSOR METABOLITES AND ENERGY Phosphoglucomutase; catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism; functions as the acceptor for a Glc-phosphotransferase; protein abundance increases in response to DNA replication stress glucose 6-phosphate metabolic process|cellular calcium ion homeostasis|galactose catabolic process|cellular cation homeostasis|glucose 1-phosphate metabolic process|trehalose biosynthetic process|UDP-glucose metabolic process|glycogen biosynthetic process phosphoglucomutase activity cytoplasm
YDL237W YDL237W AIM6 hom Verified 0.222907869090753 0.411803605910504 no 1854 0.41567109385152 1363 NA Putative protein of unknown function, required for respiratory growth; YDL237W is not an essential gene biological_process molecular_function cellular_component
YBR013C_p YBR013C YBR013C hom Uncharacterized 0.221780590987506 0.412242344683544 no 1855 0.424843447595574 1390 NA Putative protein of unknown function, haploid deletion mutant exhibits synthetic phenotype with alpha-synuclein biological_process molecular_function cellular_component
YJR099W YJR099W YUH1 hom Verified 0.221743396858264 0.412256822581513 no 1856 0.408196244259349 1350 NA FT PROTEOLYSIS Ubiquitin C-terminal hydrolase that cleaves ubiquitin-protein fusions to generate monomeric ubiquitin; hydrolyzes the peptide bond at the C-terminus of ubiquitin; also the major processing enzyme for the ubiquitin-like protein Rub1p protein deubiquitination ubiquitin-specific protease activity cytoplasm
YDL034W_d YDL034W YDL034W hom Dubious 0.221668000965 0.412286170967876 no 1857 0.409140161842099 1375 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps with verified gene GPR1/YDL035C; YDL034W is not an essential gene Unknown Unknown Unknown
YMR202W YMR202W ERG2 hom Verified 0.218447466269808 0.413540242837262 no 1858 0.478831989107193 1585 NA FF|FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM C-8 sterol isomerase, catalyzes the isomerization of the delta-8 double bond to the delta-7 position at an intermediate step in ergosterol biosynthesis ergosterol biosynthetic process C-8 sterol isomerase activity endoplasmic reticulum
YOR086C YOR086C TCB1 hom Verified 0.218389163269443 0.41356295411784 no 1859 0.39097994734771 1297 NA FT ENDOPLASMIC RETICULUM|MITOCHONDRION|PLASMA MEMBRANE Lipid-binding ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; contains three calcium and lipid binding domains; non-tagged protein also localizes to mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact biological_process lipid binding mitochondrion|plasma membrane|cortical endoplasmic reticulum
YLR188W YLR188W MDL1 hom Verified 0.218311950899831 0.413593031776411 no 1860 0.421590773131505 1399 NA FT NUCLEOTIDE METABOLISM MITOCHONDRION Mitochondrial inner membrane half-type ATP-binding cassette (ABC) transporter, mediates export of peptides generated upon proteolysis of mitochondrial proteins, plays a role in the regulation of cellular resistance to oxidative stress oligopeptide transport|oligopeptide export from mitochondrion ATPase activity|oligopeptide-transporting ATPase activity mitochondrion|integral to membrane|mitochondrial inner membrane
YER116C YER116C SLX8 hom Verified 0.218134053111313 0.413662332821712 no 1861 0.363306037445582 1187 NA FT RESPONSE TO DNA DAMAGE NUCLEUS UBIQUITIN LIGASE COMPLEX Subunit of Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex; stimulated by prior attachment of SUMO to the substrate; contains a C-terminal RING domain; forms nuclear foci upon DNA replication stress protein sumoylation|telomere maintenance|response to DNA damage stimulus|protein ubiquitination ubiquitin-protein ligase activity ubiquitin ligase complex|nucleus
YBR291C YBR291C CTP1 hom Verified 0.217698036014305 0.413832197008059 no 1862 0.421534683570152 1402 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION Mitochondrial inner membrane citrate transporter, member of the mitochondrial carrier family mitochondrial citrate transport|transmembrane transport tricarboxylate secondary active transmembrane transporter activity mitochondrion|integral to membrane|mitochondrial inner membrane
YGR127W_p YGR127W YGR127W hom Uncharacterized 0.217505696398038 0.41390713408771 no 1863 0.407935281536263 1365 NA Putative protein of unknown function; expression is regulated by Msn2p/Msn4p, indicating a possible role in stress response biological_process molecular_function cellular_component
YOR323C YOR323C PRO2 hom Verified 0.217282762767113 0.413993994766974 no 1864 0.45927450147003 1510 NA FF|FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS NUCLEUS Gamma-glutamyl phosphate reductase, catalyzes the second step in proline biosynthesis proline biosynthetic process glutamate-5-semialdehyde dehydrogenase activity nucleus|cytoplasm
YDR112W_d YDR112W IRC2 hom Dubious 0.217252669838381 0.414005720068784 no 1865 0.416174161457966 1334 NA Dubious open reading frame, unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR111C; null mutant displays increased levels of spontaneous Rad52p foci Unknown Unknown Unknown
YLL045C YLL045C RPL8B hom Verified 0.216541421912289 0.414282870477903 no 1866 0.382542628583529 1297 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Ribosomal 60S subunit protein L8B; mutation results in decreased amounts of free 60S subunits; homologous to mammalian ribosomal protein L7A, no bacterial homolog; RPL8B has a paralog, RPL8A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YLR151C YLR151C PCD1 hom Verified 0.215881760846551 0.414539957308414 no 1867 0.416190194720779 1356 NA FT NUCLEOTIDE METABOLISM Peroxisomal pyrophosphatase with specificity for coenzyme A and CoA derivatives, may function to remove potentially toxic oxidized CoA disulfide from peroxisomes to maintain the capacity for beta-oxidation of fatty acids; nudix hydrolase family member biological_process pyrophosphatase activity peroxisome
YLR191W YLR191W PEX13 hom Verified 0.215243129713125 0.414788883117951 no 1868 0.418380428482008 1396 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|PEROXISOME ORGANIZATION Integral peroxisomal membrane protein required for translocation of peroxisomal matrix proteins, interacts with the PTS1 signal recognition factor Pex5p and the PTS2 signal recognition factor Pex7p, forms a complex with Pex14p and Pex17p protein import into peroxisome matrix, docking protein binding, bridging peroxisomal membrane
YPL101W YPL101W ELP4 hom Verified 0.214108024113115 0.415231409276986 no 1869 0.431608465853469 1425 NA FT TRANSCRIPTION FROM RNA POL II|RNA PROCESSING NUCLEUS Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity regulation of transcription from RNA polymerase II promoter|tRNA wobble uridine modification ATPase activity|tRNA binding Elongator holoenzyme complex|cytoplasm
YBL044W_p YBL044W YBL044W hom Uncharacterized 0.213445662684 0.415489683668391 no 1870 0.404184940637391 1333 NA Putative protein of unknown function; YBL044W is not an essential protein biological_process molecular_function cellular_component
YBR246W YBR246W RRT2 hom Verified 0.213086768915831 0.415629642267269 no 1871 0.424881423632298 1406 NA FT VESICLE-MEDIATED TRANSPORT Protein required for last step of diphthamide biosynthesis; deletion leads to resistance to sordarin and accumulation of diphthine; WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rtt10p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription peptidyl-diphthamide biosynthetic process from peptidyl-histidine|endocytic recycling molecular_function endosome|cytoplasm
YLR144C YLR144C ACF2 hom Verified 0.212446275844238 0.415879443356488 no 1872 0.412273818213986 1372 NA FT CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION Intracellular beta-1,3-endoglucanase; expression is induced during sporulation; may have a role in cortical actin cytoskeleton assembly; protein abundance increases in response to DNA replication stress actin cytoskeleton organization glucan endo-1,3-beta-D-glucosidase activity intracellular
YIL125W YIL125W KGD1 hom Verified 0.212190283179328 0.415979293523217 no 1873 0.4284001098222 1437 NA FT KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION Component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes a key step in the tricarboxylic acid (TCA) cycle, the oxidative decarboxylation of alpha-ketoglutarate to form succinyl-CoA tricarboxylic acid cycle|2-oxoglutarate metabolic process oxoglutarate dehydrogenase (succinyl-transferring) activity mitochondrial nucleoid|mitochondrion|mitochondrial matrix|mitochondrial oxoglutarate dehydrogenase complex
YPR154W YPR154W PIN3 hom Verified 0.211719617600633 0.416162891200164 no 1874 0.415367666029804 1379 NA FT CYTOSKELETON ORGANIZATION NUCLEUS Protein that induces appearance of [PIN+] prion when overproduced actin cytoskeleton organization molecular_function nucleus|cytoplasm
YDR184C YDR184C ATC1 hom Verified 0.210903568852102 0.416481259611874 no 1875 0.428712214321866 1414 NA FT CELL CYCLE|CELL DIVISION NUCLEUS Nuclear protein; possibly involved in regulation of cation stress responses and/or in the establishment of bipolar budding pattern; relative distribution to the nucleus decreases upon DNA replication stress bipolar cellular bud site selection|response to stress molecular_function nucleus
YIL103W YIL103W DPH1 hom Verified 0.210818582699767 0.416514418758649 no 1876 0.401083879105798 1323 NA Protein required, along with Dph2p, Kti11p, Jjj3p, and Dph5p, for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); may act in a complex with Dph2p and Kti11p peptidyl-diphthamide biosynthetic process from peptidyl-histidine molecular_function cytoplasm
YNL305C YNL305C BXI1 hom Verified 0.210195151155301 0.416757681925271 no 1877 0.394216177434963 1284 NA FT SIGNALING ENDOPLASMIC RETICULUM|MITOCHONDRION Protein involved in apoptosis; variously described as containing a BCL-2 homology (BH3) domain or as a member of the BAX inhibitor family; reported to promote apoptosis under some conditions and to inhibit it in others; localizes to ER and vacuole; may link the unfolded protein response to apoptosis via regulation of calcium-mediated signaling; translocates to mitochondria under apoptosis-inducing conditions in a process involving Mir1p and Cor1p endoplasmic reticulum unfolded protein response|apoptotic process|calcium-mediated signaling molecular_function mitochondrion|integral to membrane|endoplasmic reticulum|fungal-type vacuole
YOL057W YOL057W YOL057W hom Verified 0.209000442277126 0.417223946677132 no 1878 0.41222227681752 1353 NA FT PROTEOLYSIS NUCLEUS Dipeptidyl-peptidase III; cleaves dipeptides from the amino terminus of target proteins; highly active on synthetic substrate Arg-Arg-2-naphthylamide; mammalian ortholog may be a biomarker for some cancers proteolysis dipeptidyl-peptidase activity nucleus|cytoplasm
YKR057W YKR057W RPS21A hom Verified 0.208263607627256 0.417511572754932 no 1879 0.402658358155719 1340 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21A has a paralog, RPS21B, that arose from the whole genome duplication cytoplasmic translation|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) structural constituent of ribosome cytosolic small ribosomal subunit
YER180C YER180C ISC10 hom Verified 0.208030262903511 0.417602668924099 no 1880 0.410083126875242 1346 NA FT CELL CYCLE Protein required for sporulation, transcript is induced 7.5 hours after induction of meiosis, expected to play significant role in the formation of reproductive cells sporulation resulting in formation of a cellular spore molecular_function cellular_component
YNR009W YNR009W NRM1 hom Verified 0.207751005110574 0.417711695051023 no 1881 0.413090724222861 1360 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE NUCLEUS Transcriptional co-repressor of MBF (MCB binding factor)-regulated gene expression; Nrm1p associates stably with promoters via MBF to repress transcription upon exit from G1 phase negative regulation of transcription involved in G1 phase of mitotic cell cycle repressing transcription factor binding|transcription factor binding transcription factor activity MBF transcription complex|nucleus|cytoplasm
YJR010W YJR010W MET3 hom Verified 0.207749113173895 0.417712433711002 no 1882 0.430970652272523 1410 NA FT KETONE METABOLISM|AMINO ACID METABOLISM MITOCHONDRION ATP sulfurylase, catalyzes the primary step of intracellular sulfate activation, essential for assimilatory reduction of sulfate to sulfide, involved in methionine metabolism sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)|sulfur amino acid metabolic process sulfate adenylyltransferase (ATP) activity mitochondrion|cytoplasm
YHR015W YHR015W MIP6 hom Verified 0.207401188571628 0.41784827721761 no 1883 0.393205442371511 1276 NA FT RNA LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS NUCLEAR PORE Putative RNA-binding protein; interacts with Mex67p, which is a component of the nuclear pore involved in nuclear mRNA export; MIP6 has a paralog, PES4, that arose from the whole genome duplication mRNA export from nucleus RNA binding nuclear pore
YGR034W YGR034W RPL26B hom Verified 0.206513226002538 0.41819501727418 no 1884 0.424575365959212 1410 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L26B; binds to 5.8S rRNA; homologous to mammalian ribosomal protein L26 and bacterial L24; RPL26B has a paralog, RPL26A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome|RNA binding cytosolic large ribosomal subunit
YNL077W YNL077W APJ1 hom Verified 0.206099373016795 0.418356644259289 no 1885 0.431147663791352 1434 NA FT NUCLEUS|MITOCHONDRION Chaperone with a role in SUMO-mediated protein degradation; member of the DnaJ-like family; conserved across eukaryotes; overexpression interferes with propagation of the [Psi+] prion; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; forms nuclear foci upon DNA replication stress biological_process unfolded protein binding mitochondrion|nucleus|cytoplasm
YIL066C YIL066C RNR3 hom Verified 0.20547613991505 0.418600068984946 no 1886 0.422970799396184 1395 NA FT OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM MITOCHONDRION Minor isoform of the large subunit of ribonucleotide-diphosphate reductase; the RNR complex catalyzes rate-limiting step in dNTP synthesis, regulated by DNA replication and DNA damage checkpoint pathways via localization of small subunits deoxyribonucleotide biosynthetic process ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor mitochondrion|ribonucleoside-diphosphate reductase complex|cytoplasm
YJR151W-A_p YJR151W-A YJR151W-A hom Uncharacterized 0.205320261948833 0.418660957263672 no 1887 0.421377850900116 1376 NA Putative protein of unknown function; identified by fungal homology and RT-PCR; predicted to have a role in transcription based on computational guilt by association analysis biological_process molecular_function cellular_component
YDR025W YDR025W RPS11A hom Verified 0.204116989832622 0.419131038930826 no 1888 0.425079435643175 1415 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S11 and bacterial S17; RPS11A has a paralog, RPS11B, that arose from the whole genome duplication cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|ribosomal small subunit assembly structural constituent of ribosome cytosolic small ribosomal subunit|90S preribosome
YLR288C YLR288C MEC3 hom Verified 0.204063168266026 0.419152068075968 no 1889 0.415698409350109 1355 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|GENE SILENCING NUCLEUS|CHROMOSOME DNA damage and meiotic pachytene checkpoint protein; subunit of a heterotrimeric complex (Rad17p-Mec3p-Ddc1p) that forms a sliding clamp, loaded onto partial duplex DNA by a clamp loader complex; homolog of human and S. pombe Hus1 telomere maintenance via recombination|DNA damage checkpoint|DNA metabolic process|chromatin silencing at telomere DNA binding nucleus|checkpoint clamp complex
YGR178C YGR178C PBP1 hom Verified 0.203974419161564 0.419186744601838 no 1890 0.418985259195566 1377 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|TRANSLATION NUCLEUS|MITOCHONDRION Component of glucose deprivation induced stress granules; involved in P-body-dependent granule assembly; similar to human ataxin-2; interacts with Pab1p to regulate mRNA polyadenylation; interacts with Mkt1p to regulate HO translation; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress positive regulation of translation|mRNA polyadenylation|stress granule assembly molecular_function mitochondrion|nucleus|polysome|cytoplasmic stress granule|cytoplasm
YGR159C YGR159C NSR1 hom Verified 0.203329511966546 0.419438745036257 no 1891 0.417177306774544 1374 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS|MITOCHONDRION Nucleolar protein that binds nuclear localization sequences, required for pre-rRNA processing and ribosome biogenesis ribosomal small subunit assembly|rRNA processing single-stranded DNA binding|RNA binding mitochondrion|nucleolus|nucleus
YLR282C_d YLR282C YLR282C hom Dubious 0.203076870807478 0.419537474738335 no 1892 0.411693452485108 1343 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion mutation confers an increase in Ty1 transposition Unknown Unknown Unknown
YJR074W YJR074W MOG1 hom Verified 0.202862008876812 0.419621444672409 no 1893 0.412201821232451 1369 NA FT PROTEIN LOCALIZATION|RNA LOCALIZATION NUCLEUS Conserved nuclear protein that interacts with GTP-Gsp1p, which is a Ran homolog of the Ras GTPase family, and stimulates nucleotide release, involved in nuclear protein import, nucleotide release is inhibited by Yrb1p protein import into nucleus Ran GTPase binding nucleus
YBR033W_p YBR033W EDS1 hom Uncharacterized 0.202286990797122 0.419846184794748 no 1894 0.410983957145392 1338 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Putative zinc cluster protein, predicted to be a transcription factor; not an essential gene; EDS1 has a paralog, RGT1, that arose from the whole genome duplication biological_process sequence-specific DNA binding cellular_component
YOL059W YOL059W GPD2 hom Verified 0.201555732969207 0.420132027429303 no 1895 0.44247387378506 1455 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM MITOCHONDRION NAD-dependent glycerol 3-phosphate dehydrogenase, homolog of Gpd1p, expression is controlled by an oxygen-independent signaling pathway required to regulate metabolism under anoxic conditions; located in cytosol and mitochondria; constitutively active but is inactivated via phosphorylation by energy-stress responsive kinase SNF1 NADH oxidation|glycerol metabolic process glycerol-3-phosphate dehydrogenase [NAD+] activity cytosol|mitochondrion
YOR070C YOR070C GYP1 hom Verified 0.201114515974241 0.420304515891659 no 1896 0.452739056801437 1499 NA FF|FT VESICLE-MEDIATED TRANSPORT|SIGNALING|NUCLEOTIDE METABOLISM MITOCHONDRION|GOLGI APPARATUS Cis-golgi GTPase-activating protein (GAP) for the Rab family members Ypt1p (in vivo) and for Ypt1p, Sec4p, Ypt7p, and Ypt51p (in vitro); involved in vesicle docking and fusion vesicle-mediated transport Rab GTPase activator activity mitochondrion|Golgi apparatus
YNL239W YNL239W LAP3 hom Verified 0.200484785396446 0.420550727970762 no 1897 0.415391629285285 1371 NA FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM|PROTEOLYSIS MITOCHONDRION Cysteine aminopeptidase with homocysteine-thiolactonase activity; protects cells against homocysteine toxicity; has bleomycin hydrolase activity in vitro; transcription is regulated by galactose via Gal4p; orthologous to human BLMH response to antibiotic|negative regulation of transcription from RNA polymerase II promoter|homocysteine catabolic process double-stranded DNA binding|cysteine-type peptidase activity|mRNA binding|single-stranded DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding mitochondrion|cytoplasm
YLR257W YLR257W YLR257W hom Verified 0.200369321848406 0.420595875287273 no 1898 0.425856511497691 1390 NA Protein of unknown function; protein abundance increases in response to DNA replication stress biological_process molecular_function cytoplasm
YHR162W YHR162W MPC2 hom Verified 0.1999010878285 0.420778969825428 no 1899 0.40848137994058 1347 NA Highly conserved subunit of the mitochondrial pyruvate carrier; a mitochondrial inner membrane complex comprised of Fmp37p/Mpc1p and either Mpc2p or Fmp43p/Mpc3p mediates mitochondrial pyruvate uptake; more highly expressed in glucose-containing minimal medium than in lactate-containing medium mitochondrial pyruvate transport pyruvate transmembrane transporter activity mitochondrion|integral to mitochondrial inner membrane
YMR183C YMR183C SSO2 hom Verified 0.199549398142404 0.420916503059287 no 1900 0.410183555253427 1385 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION ENDOPLASMIC RETICULUM|PLASMA MEMBRANE Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane; syntaxin homolog that is functionally redundant with Sso1p Golgi to plasma membrane transport|ascospore-type prospore assembly|vesicle fusion phosphatidic acid binding|SNAP receptor activity endoplasmic reticulum|plasma membrane|prospore membrane|cytoplasm
YIL020C YIL020C HIS6 hom Verified 0.19938797512694 0.420979633049154 no 1901 0.410005376543176 1359 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Phosphoribosyl-5-amino-1-phosphoribosyl-4-imidazolecarboxiamide isomerase, catalyzes the fourth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts histidine biosynthetic process 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity intracellular
YNR002C YNR002C ATO2 hom Verified 0.199090710259191 0.421095893955418 no 1902 0.400447735718612 1321 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION|PLASMA MEMBRANE Putative transmembrane protein involved in export of ammonia; ammonia is a starvation signal that promotes cell death in aging colonies; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family; homolog of Y. lipolytica Gpr1p; ATO2 has a paralog, ADY2, that arose from the whole genome duplication ammonium transport|nitrogen utilization ammonium transmembrane transporter activity mitochondrion|integral to membrane|plasma membrane
YML111W YML111W BUL2 hom Verified 0.197901870023229 0.421560920524089 no 1903 0.417133341529012 1371 NA FT UBIQUITIN LIGASE COMPLEX Component of the Rsp5p E3-ubiquitin ligase complex; involved in intracellular amino acid permease sorting, functions in heat shock element mediated gene expression, essential for growth in stress conditions; BUL2 has a paralog, BUL1, that arose from the whole genome duplication protein polyubiquitination|protein monoubiquitination ubiquitin-ubiquitin ligase activity ubiquitin ligase complex|cytoplasm
YKL081W YKL081W TEF4 hom Verified 0.197711260132243 0.42163548965528 no 1904 0.428390936802416 1408 NA FT TRANSLATION MITOCHONDRION RIBOSOME Gamma subunit of translational elongation factor eEF1B, stimulates the binding of aminoacyl-tRNA (AA-tRNA) to ribosomes by releasing eEF1A (Tef1p/Tef2p) from the ribosomal complex translational elongation translation elongation factor activity mitochondrion|ribosome|eukaryotic translation elongation factor 1 complex
YLR021W YLR021W IRC25 hom Verified 0.196127418386142 0.422255218114347 no 1905 0.424117941445006 1380 NA FT PROTEIN COMPLEX ORG/BIOGENESIS Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions proteasome assembly|chaperone-mediated protein complex assembly|nuclear-transcribed mRNA catabolic process, non-stop decay molecular_function intracellular
YMR166C_p YMR166C YMR166C hom Uncharacterized 0.19587155497791 0.422355350914377 no 1906 0.427573657520433 1390 NA FT MITOCHONDRION Predicted transporter of the mitochondrial inner membrane; has similarity to human mitochondrial ATP-Mg/Pi carriers; YMR166C is not an essential gene transport transporter activity integral to membrane|mitochondrial inner membrane
YNL259C YNL259C ATX1 hom Verified 0.195812587177256 0.42237842882596 no 1907 0.431241503646039 1409 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS|RESPONSE TO OXIDATIVE STRESS Cytosolic copper metallochaperone that transports copper to the secretory vesicle copper transporter Ccc2p for eventual insertion into Fet3p, which is a multicopper oxidase required for high-affinity iron uptake copper ion transport|cellular response to oxidative stress|cellular iron ion homeostasis copper chaperone activity cytosol
YLR032W YLR032W RAD5 hom Verified 0.195755308163225 0.422400846061326 no 1908 0.434240710963157 1430 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME DNA helicase; proposed to promote replication fork regression during postreplication repair by template switching; RING finger containing ubiquitin ligase; stimulates the synthesis of free and PCNA-bound polyubiquitin chains by Ubc13p-Mms2p; required for error-prone translesion synthesis; forms nuclear foci upon DNA replication stress double-strand break repair|postreplication repair|protein polyubiquitination|free ubiquitin chain polymerization four-way junction helicase activity|four-way junction DNA binding|DNA-dependent ATPase activity|Y-form DNA binding nuclear chromatin
YDR153C YDR153C ENT5 hom Verified 0.195689572093828 0.422426573436481 no 1909 0.413336086082272 1354 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p, clathrin adaptor complex AP-1, and clathrin late endosome to vacuole transport via multivesicular body sorting pathway|early endosome to Golgi transport|Golgi to endosome transport clathrin binding|phosphatidylinositol-3,5-bisphosphate binding endosome|clathrin vesicle coat|cytoplasm
YHR104W YHR104W GRE3 hom Verified 0.195675723254418 0.422431993551571 no 1910 0.423337759836285 1362 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|RESPONSE TO OXIDATIVE STRESS NUCLEUS Aldose reductase; involved in methylglyoxal, d-xylose, arabinose, and galactose metabolism; stress induced (osmotic, ionic, oxidative, heat shock, starvation and heavy metals); regulated by the HOG pathway; protein abundance increases in response to DNA replication stress galactose catabolic process|cellular response to oxidative stress|arabinose catabolic process|D-xylose catabolic process|response to stress D-xylose:NADP reductase activity|mRNA binding|glucose 1-dehydrogenase (NADP+) activity|alditol:NADP+ 1-oxidoreductase activity nucleus|cytoplasm
YNL144C_p YNL144C YNL144C hom Uncharacterized 0.195591324023413 0.42246502577389 no 1911 0.425654988597379 1403 NA FT MITOCHONDRION Putative protein of unknown function; non-tagged protein is detected in highly purified mitochondria in high-throughput studies; contains a PH domain and binds phosphatidylinositols and phosphatidylethanolamine in a large-scale study biological_process molecular_function mitochondrion
YDR348C YDR348C PAL1 hom Verified 0.194386857931797 0.422936489754558 no 1912 0.430420584141964 1425 NA FT SITE OF POLARIZED GROWTH|PLASMA MEMBRANE Protein of unknown function thought to be involved in endocytosis; Pal1p physically interacts with Ede1p and is found at endocytic sites at the cell periphery during the early stages of endocytosis; green fluorescent protein (GFP)-fusion protein also localizes to the bud neck; potential Cdc28p substrate; similar to the S. pombe Pal1 protein; relocalizes from bud neck to cytoplasm upon DNA replication stress biological_process molecular_function cell cortex|cellular bud neck|mating projection tip
YDR391C_p YDR391C YDR391C hom Uncharacterized 0.193875644561084 0.423136627337194 no 1913 0.425871985697338 1402 NA FT NUCLEUS Putative protein of unknown function, possibly involved in zinc homeostasis; Bdf1p-dependent transcription induced by salt stress; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus biological_process molecular_function nucleus|cytoplasm
YDR066C YDR066C RTR2 hom Verified 0.193354304342741 0.423340749962076 no 1914 0.427831673190268 1404 NA FT NUCLEUS Protein of unknown function; exhibits genetic interactions with Rtr1p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YDR066C is not an essential gene; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress; RTR2 has a paralog, RTR1, that arose from the whole genome duplication biological_process molecular_function cytoplasm
YJL121C YJL121C RPE1 hom Verified 0.193215905490073 0.423394941331135 no 1915 0.437963328195839 1461 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS D-ribulose-5-phosphate 3-epimerase, catalyzes a reaction in the non-oxidative part of the pentose-phosphate pathway; mutants are sensitive to oxidative stress pentose-phosphate shunt ribulose-phosphate 3-epimerase activity cytosol
YNL095C_p YNL095C YNL095C hom Uncharacterized 0.191952833877503 0.423889575706581 no 1916 0.419973475275982 1397 NA Putative protein of unknown function; predicted to contain a transmembrane domain; not an essential gene; YNL095C has a paralog, ECM3, that arose from the whole genome duplication biological_process molecular_function integral to membrane
YAR020C YAR020C PAU7 hom Verified 0.191922850044924 0.423901319204531 no 1917 0.430076571676178 1429 NA Member of the seripauperin multigene family, active during alcoholic fermentation, regulated by anaerobiosis, inhibited by oxygen, repressed by heme biological_process molecular_function cellular_component
YBR144C_d YBR144C YBR144C hom Dubious 0.190753537204519 0.424359346050983 no 1918 0.413256032984999 1355 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR144C is not an essential gene Unknown Unknown Unknown
YOR265W YOR265W RBL2 hom Verified 0.189926636879805 0.424683309574068 no 1919 0.436830522749822 1457 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION CYTOSKELETON Protein involved in microtubule morphogenesis; required for protection from excess free beta-tubulin; proposed to be involved the folding of beta-tubulin; similar to mouse beta-tubulin cofactor A; protein abundance increases in response to DNA replication stress tubulin complex assembly|tubulin complex biogenesis tubulin binding|beta-tubulin binding cytoplasm
YCR094W YCR094W CDC50 hom Verified 0.189635814006444 0.42479726044581 no 1920 0.44515147468497 1459 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION GOLGI APPARATUS Endosomal protein that interacts with phospholipid flippase Drs2p; interaction with Cdc50p is essential for Drs2p catalytic activity; mutations affect cell polarity and polarized growth; similar to Lem3p; CDC50 has a paralog, YNR048W, that arose from the whole genome duplication intracellular protein transport|phospholipid translocation|endocytosis|actin cortical patch localization phospholipid-translocating ATPase activity trans-Golgi network|late endosome membrane
YOR037W YOR037W CYC2 hom Verified 0.189436363032932 0.424875413408004 no 1921 0.402254854206472 1316 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p) cytochrome c-heme linkage|mitochondrial membrane organization oxidoreductase activity extrinsic to mitochondrial inner membrane|mitochondrion
YNL327W YNL327W EGT2 hom Verified 0.189140312730101 0.424991423339957 no 1922 0.435226007269526 1400 NA FT CELL CYCLE|CELL DIVISION Glycosylphosphatidylinositol (GPI)-anchored cell wall endoglucanase required for proper cell separation after cytokinesis, expression is activated by Swi5p and tightly regulated in a cell cycle-dependent manner cytokinesis cellulase activity fungal-type cell wall|cellular bud|cell septum
YKR085C YKR085C MRPL20 hom Verified 0.187697516261023 0.425556888701693 no 1923 0.414508064004638 1358 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YOL024W_p YOL024W YOL024W hom Uncharacterized 0.18674999639374 0.425928327076411 no 1924 0.424826948244625 1399 NA Putative protein of unknown function; predicted to have thiol-disulfide oxidoreductase active site; YOL024W has a paralog, IGD1, that arose from the whole genome duplication biological_process molecular_function cellular_component
YJR144W YJR144W MGM101 hom Verified 0.186462437459365 0.426041066407761 no 1925 0.434047980736618 1413 NA FT RESPONSE TO DNA DAMAGE|MITOCHONDRION ORGANIZATION MITOCHONDRION|CHROMOSOME Protein with a role in mitochondrial DNA recombinational repair;also involved in interstrand cross-link repair; binds to and catalyzes the annealing of single-stranded mtDNA; oligomerizes to form rings and filaments; related to Rad52-type recombination proteins, with limited overall similarity but sharing conserved functionally important residues; component of the mitochondrial nucleoid, required for the repair of oxidative mtDNA damage DNA repair|recombinational repair|DNA strand renaturation molecular_function mitochondrial nucleoid|mitochondrion
YLR273C YLR273C PIG1 hom Verified 0.186352601714602 0.426084129814505 no 1926 0.406474015739511 1316 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY Putative targeting subunit for the type-1 protein phosphatase Glc7p that tethers it to the Gsy2p glycogen synthase regulation of glycogen biosynthetic process protein phosphatase type 1 regulator activity protein phosphatase type 1 complex
YER114C YER114C BOI2 hom Verified 0.185983235153528 0.426228954182895 no 1927 0.46122152588852 1509 NA FT SIGNALING|CELL DIVISION SITE OF POLARIZED GROWTH|CYTOSKELETON Protein implicated in polar growth, functionally redundant with Boi1p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; BOI2 has a paralog, BOI1, that arose from the whole genome duplication cytokinesis, completion of separation|establishment of cell polarity|budding cell apical bud growth|Rho protein signal transduction phospholipid binding site of polarized growth|cellular bud|cellular bud neck
YOR296W_p YOR296W YOR296W hom Uncharacterized 0.185969757476291 0.426234238812946 no 1928 0.413849812249308 1359 NA Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; expressed during copper starvation; YOR296W is not an essential gene biological_process molecular_function cytoplasm
YKL222C YKL222C YKL222C hom Verified 0.185654614546343 0.426357810896753 no 1929 0.424081785718225 1402 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS|CYTOSKELETON Protein of unknown function that may interact with ribosomes, based on co-purification experiments; similar to transcriptional regulators from the zinc cluster (binuclear cluster) family; null mutant is sensitive to caffeine biological_process sequence-specific DNA binding ribosome|nucleus|mitotic spindle
YBR232C_d YBR232C YBR232C hom Dubious 0.18548438770307 0.426424562303072 no 1930 0.424142695267729 1414 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YKL069W YKL069W YKL069W hom Verified 0.18409353824698 0.426970037790059 no 1931 0.442112462600705 1478 NA FT OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS NUCLEUS Methionine-R-sulfoxide reductase; reduces the R enantiomer of free Met-SO, in contrast to Ycl033Cp which reduces Met-R-SO in a peptide linkage; has a role in protection against oxidative stress; relative distribution to the nucleus increases upon DNA replication stress cellular response to oxidative stress methionine-R-sulfoxide reductase activity nucleus|cytoplasm
YCR073C YCR073C SSK22 hom Verified 0.183775552970565 0.427094767688301 no 1932 0.408533327028277 1363 NA FT SIGNALING|PROTEIN PHOSPHORYLATION MAP kinase kinase kinase of the HOG1 mitogen-activated signaling pathway; functionally redundant with, and homologous to, Ssk2p; interacts with and is activated by Ssk1p; phosphorylates Pbs2p MAPK cascade involved in osmosensory signaling pathway|protein phosphorylation protein kinase activity|MAP kinase kinase kinase activity cellular_component
YDR494W YDR494W RSM28 hom Verified 0.183016753332198 0.427392436688203 no 1933 0.426676154522996 1406 NA FT TRANSLATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the small subunit; genetic interactions suggest a possible role in promoting translation initiation cytoplasmic translation|translational initiation structural constituent of ribosome mitochondrion|mitochondrial small ribosomal subunit
YNL334C YNL334C SNO2 hom Verified 0.182719224284775 0.427509165450348 no 1934 0.427088262783503 1396 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Protein of unknown function, nearly identical to Sno3p; expression is induced before the diauxic shift and also in the absence of thiamin pyridoxine metabolic process|thiamine biosynthetic process molecular_function cellular_component
YDL223C YDL223C HBT1 hom Verified 0.182409932896218 0.427630515626995 no 1935 0.447795569791204 1479 NA Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis cell morphogenesis involved in conjugation with cellular fusion molecular_function plasma membrane|mating projection
YLR004C YLR004C THI73 hom Verified 0.182330330784492 0.427661748546651 no 1936 0.412344824914447 1385 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|PLASMA MEMBRANE Putative plasma membrane permease proposed to be involved in carboxylic acid uptake and repressed by thiamine; substrate of Dbf2p/Mob1p kinase; transcription is altered if mitochondrial dysfunction occurs transport transporter activity integral to membrane|endoplasmic reticulum
YNL332W YNL332W THI12 hom Verified 0.181299861600845 0.428066107327401 no 1937 0.412855313115896 1353 NA Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13 thiamine biosynthetic process molecular_function cellular_component
YDR003W YDR003W RCR2 hom Verified 0.179192715339807 0.428893191734207 no 1938 0.427712501273707 1398 NA FT VESICLE-MEDIATED TRANSPORT Vacuolar protein; presumably functions within the endosomal-vacuolar trafficking pathway, affecting events that determine whether plasma membrane proteins are degraded or routed to the plasma membrane; RCR2 has a paralog, RCR1, that arose from the whole genome duplication vesicle-mediated transport molecular_function vesicle|integral to membrane|fungal-type vacuole|cytoplasm
YLR455W YLR455W YLR455W hom Verified 0.178559294515351 0.429141879497985 no 1939 0.435618667015053 1440 NA FT NUCLEUS Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO); protein abundance increases in response to DNA replication stress biological_process molecular_function nucleus
YOR283W YOR283W YOR283W hom Verified 0.178289349428825 0.429247871368678 no 1940 0.420336299013227 1389 NA FT CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY NUCLEUS Phosphatase with a broad substrate specificity and some similarity to GPM1/YKL152C, a phosphoglycerate mutase; YOR283W is not an essential gene dephosphorylation phosphatase activity nucleus|cytoplasm
YGL146C_p YGL146C RRT6 hom Uncharacterized 0.178145188771333 0.42930447703677 no 1941 0.417686957213758 1379 NA Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; contains two putative transmembrane spans, but no significant homology to other known proteins biological_process molecular_function membrane
YCR009C YCR009C RVS161 hom Verified 0.17810021549034 0.429322136400681 no 1942 0.43234517191241 1415 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION|RESPONSE TO NUTRIENT LEVELS SITE OF POLARIZED GROWTH|CYTOSKELETON Amphiphysin-like lipid raft protein; interacts with Rvs167p and regulates polarization of the actin cytoskeleton, endocytosis, cell polarity, cell fusion and viability following starvation or osmotic stress conjugation with cellular fusion|actin cytoskeleton reorganization|endocytosis|actin cortical patch localization|response to starvation|response to osmotic stress|lipid tube assembly|actin cytoskeleton organization cytoskeletal protein binding|lipid binding membrane raft|mating projection tip|mating projection|actin cortical patch
YOR258W YOR258W HNT3 hom Verified 0.17781677382851 0.42943343683653 no 1943 0.440937523779631 1454 NA FT RESPONSE TO DNA DAMAGE NUCLEUS DNA 5' AMP hydrolase involved in DNA repair; member of the histidine triad (HIT) superfamily of nucleotide-binding proteins; homolog of Aprataxin, a Hint related protein that is mutated in individuals with ataxia with oculomotor apraxia; relative distribution to nuclear foci decreases upon DNA replication stress response to DNA damage stimulus DNA 5'-adenosine monophosphate hydrolase activity nucleus|cytoplasm
YLR204W YLR204W QRI5 hom Verified 0.177483337875387 0.429564375957982 no 1944 0.4478898332465 1478 NA FF|FT RNA PROCESSING MITOCHONDRION Mitochondrial inner membrane protein, required for accumulation of spliced COX1 mRNA; may have an additional role in translation of COX1 mRNA mRNA processing molecular_function mitochondrion|integral to mitochondrial inner membrane
YDL053C YDL053C PBP4 hom Verified 0.176555506387067 0.429928772845725 no 1945 0.433510543050348 1426 NA FT NUCLEUS Pbp1p binding protein; interacts strongly with Pab1p-binding protein 1 (Pbp1p) in the yeast two-hybrid system; also interacts with Lsm12p in a copurification assay; relative distribution to the nucleus increases upon DNA replication stress biological_process molecular_function nucleus|cytoplasmic stress granule|cytoplasm
YDR001C YDR001C NTH1 hom Verified 0.176322449632514 0.430020313035998 no 1946 0.429777993875091 1424 NA FT CARBOHYDRATE METABOLISM Neutral trehalase, degrades trehalose; required for thermotolerance and may mediate resistance to other cellular stresses; may be phosphorylated by Cdc28p; NTH1 has a paralog, NTH2, that arose from the whole genome duplication trehalose catabolic process|response to stress alpha,alpha-trehalase activity cytosol|cytoplasm
YOR354C YOR354C MSC6 hom Verified 0.174785998579954 0.430623895245984 no 1947 0.434364108782124 1435 NA FT CELL CYCLE MITOCHONDRION Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies reciprocal meiotic recombination molecular_function mitochondrion
YNL292W YNL292W PUS4 hom Verified 0.173562863512256 0.431104509801693 no 1948 0.431973366194826 1430 NA FT RNA PROCESSING NUCLEUS|MITOCHONDRION Pseudouridine synthase, catalyzes only the formation of pseudouridine-55 (Psi55), a highly conserved tRNA modification, in mitochondrial and cytoplasmic tRNAs; PUS4 overexpression leads to translational derepression of GCN4 (Gcd- phenotype) tRNA modification pseudouridine synthase activity mitochondrion|nucleus
YER059W YER059W PCL6 hom Verified 0.173436771268017 0.431154061875319 no 1949 0.431562702604862 1406 NA FT CELL CYCLE|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION|GEN. OF PRECURSOR METABOLITES AND ENERGY NUCLEUS Pho85p cyclin of the Pho80p subfamily; forms the major Glc8p kinase together with Pcl7p and Pho85p; involved in the control of glycogen storage by Pho85p; stabilized by Elongin C binding regulation of glycogen catabolic process|regulation of glycogen biosynthetic process cyclin-dependent protein kinase regulator activity cyclin-dependent protein kinase holoenzyme complex
YBR145W YBR145W ADH5 hom Verified 0.172892328133065 0.431368031053134 no 1950 0.432018433025727 1418 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM NUCLEUS Alcohol dehydrogenase isoenzyme V; involved in ethanol production; ADH5 has a paralog, ADH1, that arose from the whole genome duplication NADH oxidation|ethanol biosynthetic process involved in glucose fermentation to ethanol|amino acid catabolic process to alcohol via Ehrlich pathway alcohol dehydrogenase (NAD) activity nucleus|cytoplasm
YLR205C YLR205C HMX1 hom Verified 0.172756039713109 0.431421596314113 no 1951 0.417525488571354 1364 NA FT ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants response to oxidative stress|cellular iron ion homeostasis|heme catabolic process heme oxygenase (decyclizing) activity endoplasmic reticulum|membrane|nuclear outer membrane
YPL149W YPL149W ATG5 hom Verified 0.17194018633449 0.431742276448296 no 1952 0.422353700738872 1403 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS Conserved protein involved in autophagy and the Cvt pathway; undergoes conjugation with Atg12p to form a complex involved in Atg8p lipidation; conjugated Atg12p also forms a complex with Atg16p that is essential for autophagosome formation C-terminal protein lipidation|mitochondrion degradation|piecemeal microautophagy of nucleus|macroautophagy|CVT pathway Atg8 ligase activity cytosol|Atg12-Atg5-Atg16 complex|pre-autophagosomal structure|autophagic vacuole
YGR295C YGR295C COS6 hom Verified 0.171424911272713 0.431944834164838 no 1953 0.43046190684493 1395 NA Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins biological_process molecular_function integral to membrane|fungal-type vacuole
YCL005W YCL005W LDB16 hom Verified 0.17120521333521 0.432031204185379 no 1954 0.454706632109103 1514 NA FT MITOCHONDRION Protein of unknown function; null mutants have decreased net negative cell surface charge; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; native protein is detected in purified mitochondria biological_process molecular_function mitochondrion|lipid particle
YJL212C YJL212C OPT1 hom Verified 0.170937617884367 0.432136408580438 no 1955 0.430920652704745 1455 NA FT PROTEIN LOCALIZATION PLASMA MEMBRANE Proton-coupled oligopeptide transporter of the plasma membrane; also transports glutathione and phytochelatin; member of the OPT family oligopeptide transport|sulfur compound metabolic process oligopeptide transporter activity|proton-dependent oligopeptide secondary active transmembrane transporter activity integral to membrane|integral to plasma membrane
YLR414C YLR414C PUN1 hom Verified 0.170661597075227 0.432244930423261 no 1956 0.402253682737835 1303 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL WALL ORG/BIOGENESIS PLASMA MEMBRANE Plasma membrane protein with a role in cell wall integrity; co-localizes with Sur7p in punctate membrane patches; null mutant displays decreased thermotolerance; transcription induced upon cell wall damage and metal ion stress fungal-type cell wall organization|protein oligomerization molecular_function integral to membrane|membrane raft|plasma membrane|cellular bud|cytoplasm
YGL114W_p YGL114W YGL114W hom Uncharacterized 0.17057684929354 0.43227825134826 no 1957 0.419549197855239 1367 NA FT PROTEIN LOCALIZATION Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters transport oligopeptide transporter activity integral to membrane|membrane
YHR181W YHR181W SVP26 hom Verified 0.170411250753578 0.432343362366142 no 1958 0.412614932511974 1354 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS Integral membrane protein of the early Golgi apparatus and endoplasmic reticulum, involved in COP II vesicle transport; may also function to promote retention of proteins in the early Golgi compartment protein retention in Golgi apparatus|fungal-type cell wall organization|protein glycosylation|ER to Golgi vesicle-mediated transport COPII adaptor activity integral to endoplasmic reticulum membrane|integral to membrane|endoplasmic reticulum|integral to Golgi membrane|ER to Golgi transport vesicle
YLR210W YLR210W CLB4 hom Verified 0.17035431021762 0.432365751009004 no 1959 0.429379351895355 1396 NA FT CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION NUCLEUS|CYTOSKELETON B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation G2/M transition of mitotic cell cycle|S phase of mitotic cell cycle|regulation of cyclin-dependent protein kinase activity|positive regulation of spindle pole body separation cyclin-dependent protein kinase regulator activity nucleus|spindle pole body|cytoplasm
YGL255W YGL255W ZRT1 hom Verified 0.169986407037804 0.432510413342338 no 1960 0.421495391670395 1393 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE High-affinity zinc transporter of the plasma membrane, responsible for the majority of zinc uptake; transcription is induced under low-zinc conditions by the Zap1p transcription factor high-affinity zinc ion transport high affinity zinc uptake transmembrane transporter activity integral to membrane|integral to plasma membrane
YBR104W YBR104W YMC2 hom Verified 0.168788842634161 0.432981367347006 no 1961 0.410035510692533 1358 NA FT MITOCHONDRION Putative mitochondrial inner membrane transporter; proposed role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; YMC2 has a paralog, YMC1, that arose from the whole genome duplication mitochondrial transport|transmembrane transport organic acid transmembrane transporter activity mitochondrion|integral to membrane
YNL218W YNL218W MGS1 hom Verified 0.168552204660453 0.433074438848211 no 1962 0.413983019743213 1340 NA FT RESPONSE TO DNA DAMAGE NUCLEUS Protein with DNA-dependent ATPase and ssDNA annealing activities; involved in maintenance of genome; interacts functionally with DNA polymerase delta; homolog of human Werner helicase interacting protein (WHIP); forms nuclear foci upon DNA replication stress regulation of DNA repair|DNA replication, Okazaki fragment processing|DNA strand renaturation ubiquitin binding|single-stranded DNA-dependent ATPase activity|enzyme activator activity nucleus|cytoplasm
YAL019W YAL019W FUN30 hom Verified 0.168265944631906 0.433187032039275 no 1963 0.432131777854091 1429 NA FT CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS|MITOCHONDRION|CHROMOSOME Snf2p family member with ATP-dependent chromatin remodeling activity; has a role in silencing at the mating type locus, telomeres and centromeres; enriched at centromeres and is required for correct chromatin structure around centromeres, as well as at the boundary element of the silent HMR; recruited to DNA double-strand breaks (DSBs) where it promotes 5' strand resection of DSBs; potential Cdc28p substrate chromosome organization|chromatin silencing at rDNA|heterochromatin maintenance involved in chromatin silencing|chromatin silencing at telomere|chromatin silencing at silent mating-type cassette|heterochromatin assembly involved in chromatin silencing chromatin binding|DNA-dependent ATPase activity|DNA binding|protein homodimerization activity mitochondrion|mating-type region heterochromatin|nucleus
YMR257C YMR257C PET111 hom Verified 0.167612089239379 0.433444229959842 no 1964 0.434430558748319 1438 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial translational activator specific for the COX2 mRNA; located in the mitochondrial inner membrane mitochondrial respiratory chain complex IV biogenesis|positive regulation of mitochondrial translation translation regulator activity mitochondrion|mitochondrial inner membrane
YPR134W YPR134W MSS18 hom Verified 0.167019458552651 0.433677369133126 no 1965 0.440118990676115 1457 NA FT RNA PROCESSING MITOCHONDRION Nuclear encoded protein needed for efficient splicing of mitochondrial COX1 aI5beta intron; mss18 mutations block cleavage of 5' exon - intron junction; phenotype of intronless strain suggests additional functions Group I intron splicing molecular_function mitochondrion
YGR249W YGR249W MGA1 hom Verified 0.166432303972522 0.43390837678096 no 1966 0.432974662113009 1445 NA FT NUCLEUS Protein similar to heat shock transcription factor; multicopy suppressor of pseudohyphal growth defects of ammonium permease mutants filamentous growth sequence-specific DNA binding|DNA binding|sequence-specific DNA binding transcription factor activity nucleus
YBL021C YBL021C HAP3 hom Verified 0.164817882746797 0.434543664071523 no 1967 0.443820364956547 1468 NA FT TRANSCRIPTION FROM RNA POL II|OXIDATION-REDUCTION PROCESS|RESPONSE TO NUTRIENT LEVELS|GEN. OF PRECURSOR METABOLITES AND ENERGY NUCLEUS Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences contributing to both complex assembly and DNA binding carbon catabolite activation of transcription from RNA polymerase II promoter|regulation of cellular respiration RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription CCAAT-binding factor complex
YPR074C YPR074C TKL1 hom Verified 0.164203634930864 0.4347854198441 no 1968 0.463968972468061 1521 NA FF|FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS Transketolase; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids; TKL1 has a paralog, TKL2, that arose from the whole genome duplication pentose-phosphate shunt transketolase activity cytoplasm
YLR001C_p YLR001C YLR001C hom Uncharacterized 0.164053208365145 0.43484462848108 no 1969 0.416374371994786 1378 NA FT MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; predicted to be palmitoylated biological_process molecular_function mitochondrion|fungal-type vacuole membrane
YFL004W YFL004W VTC2 hom Verified 0.163624515437662 0.435013372139428 no 1970 0.433092334640187 1454 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT ENDOPLASMIC RETICULUM Subunit of the vacuolar transporter chaperone (VTC) complex involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion polyphosphate metabolic process|vacuolar transport|microautophagy|protein localization|vacuole fusion, non-autophagic molecular_function fungal-type vacuole membrane|integral to membrane|endoplasmic reticulum|vacuolar transporter chaperone complex
YFR013W YFR013W IOC3 hom Verified 0.163507298111062 0.435059513708891 no 1971 0.479023288147895 1602 NA FT CHROMATIN ORGANIZATION NUCLEUS Subunit of the Isw1a complex; Isw1a has nucleosome-stimulated ATPase activity and represses transcription initiation by specific positioning of a promoter proximal dinucleosome; IOC3 has a paralog, ESC8, that arose from the whole genome duplication chromatin remodeling nucleosome binding|ATPase activity|DNA binding ISW1 complex
YGL160W YGL160W AIM14 hom Verified 0.163136269927351 0.435205571516409 no 1972 0.449407800237324 1491 NA FT ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|GEN. OF PRECURSOR METABOLITES AND ENERGY NADPH oxidase localized to the perinuclear ER; produces superoxide from NADPH; overexpression causes MCA1 dependent apoptosis; likely involved in superoxide-mediated regulation of the actin cytoskeleton; member of a conserved superfamily of NADPH oxidases (NOX enzymes); has similarity to iron/copper reductases (FRE1-8), particularly Fre8p biological_process oxidoreductase activity, oxidizing metal ions integral to membrane|ribosome
YPL159C YPL159C PET20 hom Verified 0.162824749930443 0.435328210343569 no 1973 0.438699280394486 1443 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Mitochondrial protein, required for respiratory growth under some conditions and for stability of the mitochondrial genome aerobic respiration molecular_function mitochondrion
YCL042W_p YCL042W YCL042W hom Uncharacterized 0.162248794047365 0.435554968354585 no 1974 0.443949766439195 1502 NA Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm biological_process molecular_function cytoplasm
YJR111C_p YJR111C YJR111C hom Uncharacterized 0.161556041837832 0.435827737993125 no 1975 0.427538955185196 1399 NA FT OXIDATION-REDUCTION PROCESS MITOCHONDRION Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondria biological_process molecular_function mitochondrion
YNL314W YNL314W DAL82 hom Verified 0.16089880721301 0.436086550885716 no 1976 0.44450446367125 1453 NA FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS NUCLEUS Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain allantoin catabolic process|nitrogen catabolite activation of transcription from RNA polymerase II promoter sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity nucleus
YOR309C_d YOR309C YOR309C hom Dubious 0.160830704484281 0.436113370674796 no 1977 0.445545528439405 1456 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NOP58 Unknown Unknown Unknown
YML002W_p YML002W YML002W hom Uncharacterized 0.160552961522475 0.436222752705052 no 1978 0.406575719571834 1337 NA Putative protein of unknown function; expression induced by heat and by calcium shortage biological_process molecular_function cellular_component
YLR118C YLR118C YLR118C hom Verified 0.160318419418818 0.436315124970625 no 1979 0.433053293394958 1416 NA FT KETONE METABOLISM|LIPID METABOLISM NUCLEUS Acyl-protein thioesterase responsible for depalmitoylation of Gpa1p; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus and is induced in response to the DNA-damaging agent MMS protein deacylation palmitoyl-(protein) hydrolase activity nucleus|cytoplasm
YOR147W YOR147W MDM32 hom Verified 0.15987778033555 0.436488676038116 no 1980 0.422786898517685 1403 NA FT ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS MITOCHONDRION Mitochondrial inner membrane protein with similarity to Mdm31p, required for normal mitochondrial morphology and inheritance; interacts genetically with MMM1, MDM10, MDM12, and MDM34 mitochondrion inheritance|cellular ion homeostasis|mitochondrion organization molecular_function mitochondrion|mitochondrial inner membrane
YDR377W YDR377W ATP17 hom Verified 0.157127366608546 0.437572235015892 no 1981 0.457975174750553 1512 NA FT ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS MITOCHONDRION Subunit f of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis ATP synthesis coupled proton transport hydrogen ion transporting ATP synthase activity, rotational mechanism|ATPase activity|proton-transporting ATPase activity, rotational mechanism mitochondrion|mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
YJL133W YJL133W MRS3 hom Verified 0.156690304980349 0.437744464100592 no 1982 0.419483237227346 1371 NA FT RNA PROCESSING|ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION Iron transporter, mediates Fe2+ transport across inner mito membrane; mitochondrial carrier family member; active under low-iron conditions; may transport other cations; MRS3 has a paralog, MRS4, that arose from the whole genome duplication mitochondrial iron ion transport|RNA splicing iron ion transmembrane transporter activity mitochondrion|integral to membrane
YJL092W YJL092W SRS2 hom Verified 0.156180825657023 0.437945245084715 no 1983 0.447843370037619 1488 NA FT RESPONSE TO DNA DAMAGE NUCLEUS DNA helicase and DNA-dependent ATPase involved in DNA repair and checkpoint recovery, needed for proper timing of commitment to meiotic recombination and transition from Meiosis I to II; blocks trinucleotide repeat expansion; affects genome stability DNA repair|double-strand break repair via nonhomologous end joining|DNA duplex unwinding DNA helicase activity nucleus
YDL110C YDL110C TMA17 hom Verified 0.155693709909565 0.438137227736125 no 1984 0.443359532081032 1458 NA FT NUCLEUS Protein of unknown function that associates with ribosomes; heterozygous deletion demonstrated increases in chromosome instability in a rad9 deletion background; protein abundance is decreased upon intracellular iron depletion biological_process molecular_function ribosome|nucleus|cytoplasm
YML009C-A_d YML009C-A YML009C-A hom Dubious 0.15552121317494 0.438205215852527 no 1985 0.44456899327318 1490 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YOR172W YOR172W YRM1 hom Verified 0.155511571287454 0.438209016174069 no 1986 0.439398376014443 1468 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Zn2-Cys6 zinc-finger transcription factor that activates genes involved in multidrug resistance; paralog of Yrr1p, acting on an overlapping set of target genes regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding|nucleic acid binding transcription factor activity nucleus|cytoplasm
YLR143W YLR143W DPH6 hom Verified 0.155393838158283 0.43825542079951 no 1987 0.449186724579156 1499 NA Diphthamide synthetase; catalyzes the last amidation step of diphthamide biosynthesis using ammonium and ATP; evolutionarily conserved in eukaryotes; dph6 mutants exhibit diphthine accumulation and resistance to sordarin, which is indicative of defects in diphthamide formation on EF2; green fluorescent protein (GFP)-tagged protein localizes to the cytoplasm; DPH6/YLR143W is not an essential gene biological_process molecular_function cytoplasm
YOR012W_p YOR012W YOR012W hom Uncharacterized 0.155295982546998 0.438293991328369 no 1988 0.407254079754934 1351 NA Putative protein of unknown function biological_process molecular_function cellular_component
YDL229W YDL229W SSB1 hom Verified 0.154495651323635 0.438609469898097 no 1989 0.429435174942862 1410 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RESPONSE TO NUTRIENT LEVELS Cytoplasmic ATPase that is a ribosome-associated molecular chaperone; functions with J-protein partner Zuo1p; may be involved in folding of newly-made polypeptide chains; member of the HSP70 family; interacts with phosphatase subunit Reg1p; SSB1 has a paralog, SSB2, that arose from the whole genome duplication cytoplasmic translation|cellular response to glucose starvation|translational termination|ribosomal subunit export from nucleus|regulation of translational fidelity|rRNA processing|'de novo' cotranslational protein folding unfolded protein binding|ATPase activity|calmodulin binding plasma membrane|polysome|cytoplasm
YIR029W YIR029W DAL2 hom Verified 0.154423395052318 0.438637954159917 no 1990 0.429373561776813 1411 NA Allantoicase, converts allantoate to urea and ureidoglycolate in the second step of allantoin degradation; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation allantoin catabolic process allantoicase activity cellular_component
YMR322C_p YMR322C SNO4 hom Uncharacterized 0.154298638586593 0.438687135356498 no 1991 0.426973693123983 1390 NA FT PROTEOLYSIS Possible chaperone and cysteine protease, similar to bacterial Hsp31 and yeast Hsp31p, Hsp32p, and Hsp33p; DJ-1/ThiJ/PfpI superfamily member; predicted involvement in pyridoxine metabolism; induced by mild heat stress and copper deprivation biological_process cysteine-type peptidase activity cellular_component
YDL179W YDL179W PCL9 hom Verified 0.153965730188908 0.438818378343446 no 1992 0.447545260466687 1470 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CELL DIVISION|PROTEIN PHOSPHORYLATION SITE OF POLARIZED GROWTH Cyclin, forms a functional kinase complex with Pho85p cyclin-dependent kinase (Cdk), expressed in late M/early G1 phase, activated by Swi5p regulation of establishment or maintenance of cell polarity|regulation of transcription involved in G1/S phase of mitotic cell cycle cyclin-dependent protein kinase regulator activity cyclin-dependent protein kinase holoenzyme complex|incipient cellular bud site|cellular bud neck
YMR287C YMR287C DSS1 hom Verified 0.153224187988322 0.439110741820065 no 1993 0.434938893293412 1391 NA FT MITOCHONDRION 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs mitochondrial RNA catabolic process exoribonuclease II activity mitochondrion|mitochondrial degradosome
YBR239C_p YBR239C ERT1 hom Uncharacterized 0.152974397660224 0.439209232669614 no 1994 0.451014827257147 1499 NA FT TRANSCRIPTION FROM RNA POL II|SIGNALING|CARBOHYDRATE METABOLISM NUCLEUS Transcriptional regulator of nonfermentable carbon utilization; GFP-fusion protein localizes to cytoplasm, nucleus; null mutation affects periodicity of transcriptional and metabolic oscillation; plays role in restricting Ty1 transposition biological_process sequence-specific DNA binding nucleus|cytoplasm
YBR191W YBR191W RPL21A hom Verified 0.152827502974163 0.43926715413363 no 1995 0.437751492419624 1430 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L21A; homologous to mammalian ribosomal protein L21, no bacterial homolog; RPL21A has a paralog, RPL21B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YGR028W YGR028W MSP1 hom Verified 0.152631502405984 0.439344440369059 no 1996 0.436538926660806 1446 NA FT PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial protein involved in sorting of proteins in the mitochondria; putative membrane-spanning ATPase protein targeting to mitochondrion ATPase activity mitochondrial outer membrane|mitochondrion
YMR068W YMR068W AVO2 hom Verified 0.15201315342779 0.439588280642321 no 1997 0.460346841190673 1513 NA FT SIGNALING|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION PLASMA MEMBRANE Component of a complex containing the Tor2p kinase and other proteins, which may have a role in regulation of cell growth fungal-type cell wall organization|TOR signaling cascade|regulation of cell growth|establishment or maintenance of actin cytoskeleton polarity molecular_function TORC2 complex|cytoplasm
YBR216C YBR216C YBP1 hom Verified 0.151906125065017 0.439630488629481 no 1998 0.432940857501407 1423 NA FT RESPONSE TO OXIDATIVE STRESS Protein involved in cellular response to oxidative stress; required for oxidation of specific cysteine residues of transcription factor Yap1p, resulting in nuclear localization of Yap1p in response to stress; YBP1 has a paralog, YBP2, that arose from the whole genome duplication cellular response to oxidative stress molecular_function cytoplasm
YPR015C_p YPR015C YPR015C hom Uncharacterized 0.151315739676175 0.43986332688735 no 1999 0.440218786649703 1468 NA Putative protein of unknown function; overexpression causes a cell cycle delay or arrest biological_process sequence-specific DNA binding cellular_component
YDL019C YDL019C OSH2 hom Verified 0.151232885840462 0.439896004739611 no 2000 0.455137986712405 1497 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION ENDOPLASMIC RETICULUM|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability endocytosis|maintenance of cell polarity|sterol transport|exocytosis lipid binding|oxysterol binding|sterol transporter activity|1-phosphatidylinositol binding endoplasmic reticulum|plasma membrane|cortical endoplasmic reticulum|cellular bud neck
YPL070W YPL070W MUK1 hom Verified 0.150993130560083 0.439990567394724 no 2001 0.438938426239726 1448 NA Cytoplasmic protein of unknown function containing a Vps9 domain; computational analysis of large-scale protein-protein interaction data suggests a possible role in transcriptional regulation biological_process molecular_function cytoplasm
YKR049C YKR049C FMP46 hom Verified 0.150633018170471 0.440132606917164 no 2002 0.422187352006036 1407 NA FT OXIDATION-REDUCTION PROCESS MITOCHONDRION Putative redox protein containing a thioredoxin fold; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process oxidoreductase activity mitochondrion
YGR136W YGR136W LSB1 hom Verified 0.150228345712815 0.440292231509179 no 2003 0.421060296928896 1393 NA FT NUCLEUS Protein containing an N-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein increases in abundance and forms nuclear foci in response to DNA replication stress biological_process molecular_function nucleus|cytoplasm
YAL044W-A_p YAL044W-A YAL044W-A hom Uncharacterized 0.149997246719872 0.440383393742084 no 2004 0.414394144889358 1352 NA Putative protein of unknown function; similar to S. pombe uvi31 which is a putative DNA repair protein biological_process molecular_function cellular_component
YDR033W YDR033W MRH1 hom Verified 0.149869164506176 0.440433920034126 no 2005 0.440953910920936 1458 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION|PLASMA MEMBRANE Protein that localizes primarily to the plasma membrane; also found at the nuclear envelope; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; MRH1 has a paralog, YRO2, that arose from the whole genome duplication biological_process molecular_function mitochondrion|integral to membrane|plasma membrane
YMR121C YMR121C RPL15B hom Verified 0.148947441519752 0.440797552897499 no 2006 0.407336222080602 1352 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L15B; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15B has a paralog, RPL15A, that arose from the whole genome duplication; relocalizes from nucleus to nucleolus upon DNA replication stress cytoplasmic translation structural constituent of ribosome|RNA binding cytosolic large ribosomal subunit
YMR066W YMR066W SOV1 hom Verified 0.148537823233326 0.44095916919501 no 2007 0.44599818450245 1475 NA FT MITOCHONDRION Mitochondrial protein of unknown function biological_process molecular_function mitochondrion
YHR087W YHR087W RTC3 hom Verified 0.148091128921911 0.441135425173274 no 2008 0.4498592830228 1496 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Protein of unknown function involved in RNA metabolism; has structural similarity to SBDS, the human protein mutated in Shwachman-Diamond Syndrome (the yeast SBDS ortholog = SDO1); null mutation suppresses cdc13-1 temperature sensitivity; protein abundance increases in response to DNA replication stress RNA metabolic process molecular_function nucleus|cytoplasm
YCR002C YCR002C CDC10 hom Verified 0.147630091930672 0.441317352692028 no 2009 0.450768682444017 1474 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH|CYTOSKELETON Component of the septin ring, required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins between mother and daughter cells; N-terminus interacts with phosphatidylinositol-4,5-bisphosphate; protein abundance increases under DNA damage stress sporulation|maintenance of cell polarity|exit from mitosis|cell cycle cytokinesis|septin ring assembly protein complex scaffold|structural molecule activity|GTP binding|GTPase activity|1-phosphatidylinositol binding spindle microtubule|ascospore-type prospore|septin complex|prospore membrane|mating projection base|meiotic spindle|septin filament array|cellular bud neck septin ring|mating projection tip
YGR261C YGR261C APL6 hom Verified 0.147603550998327 0.441327826254916 no 2010 0.460247399713554 1527 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Beta3-like subunit of the yeast AP-3 complex; functions in transport of alkaline phosphatase to the vacuole via the alternate pathway; exists in both cytosolic and peripherally associated membrane-bound pools vesicle-mediated transport|Golgi to vacuole transport molecular_function AP-3 adaptor complex
YGR121W-A_p YGR121W-A YGR121W-A hom Uncharacterized 0.146753276897045 0.441663382458471 no 2011 0.442275682817995 1451 NA Putative protein of unknown function biological_process molecular_function cellular_component
YHR041C YHR041C SRB2 hom Verified 0.146092455141095 0.441924201220161 no 2012 0.476594797252353 1576 NA FT TRANSCRIPTION FROM RNA POL II|RIBOSOME BIOGENESIS|RESPONSE TO NUTRIENT LEVELS NUCLEUS RNA POL II, HOLOENZYME Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; general transcription factor involved in telomere maintenance negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter in response to chemical stimulus|RNA polymerase II transcriptional preinitiation complex assembly|negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter in response to nutrient levels|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly|core RNA polymerase II binding transcription factor activity|RNA polymerase II transcription factor recruiting transcription factor activity|TBP-class protein binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly|protein domain specific binding core mediator complex
YLR394W YLR394W CST9 hom Verified 0.145747548593848 0.442060341883606 no 2013 0.450310565589019 1498 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME SUMO E3 ligase; required for synaptonemal complex formation; localizes to synapsis initiation sites on meiotic chromosomes; potential Cdc28p substrate synaptonemal complex assembly|protein sumoylation|synapsis|reciprocal meiotic recombination SUMO ligase activity condensed nuclear chromosome|nuclear chromosome
YLR300W YLR300W EXG1 hom Verified 0.145585717731971 0.442124221722993 no 2014 0.432398426709064 1419 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM Major exo-1,3-beta-glucanase of the cell wall, involved in cell wall beta-glucan assembly; exists as three differentially glycosylated isoenzymes fungal-type cell wall organization|cellular glucan metabolic process glucan exo-1,3-beta-glucosidase activity extracellular region|fungal-type cell wall
YPR045C YPR045C THP3 hom Verified 0.14557700126548 0.442127662435031 no 2015 0.419401616855081 1409 NA FT RNA PROCESSING NUCLEUS|CHROMOSOME Protein that forms a complex with Csn12p that is recruited to transcribed genes and may have a role in transcription elongation; possibly involved in splicing based on pre-mRNA accumulation defect for many intron-containing genes mRNA splicing, via spliceosome molecular_function nucleus|transcriptionally active chromatin
YOR013W_d YOR013W IRC11 hom Dubious 0.14389563370923 0.442791441800614 no 2016 0.427686623539819 1400 NA Dubious opening reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YOR012C; null mutant displays increased levels of spontaneous Rad52 foci Unknown Unknown Unknown
YPR200C YPR200C ARR2 hom Verified 0.143827034418118 0.442818527221973 no 2017 0.441901128639537 1449 NA Arsenate reductase required for arsenate resistance; converts arsenate to arsenite which can then be exported from cells by Arr3p response to arsenic-containing substance arsenate reductase activity cellular_component
YEL044W YEL044W IES6 hom Verified 0.143637757983524 0.44289326162444 no 2018 0.458783762792897 1531 NA FT NUCLEUS Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions; human ortholog INO80C is a member of the human INO80 complex; implicated in DNA repair based on genetic interactions with RAD52 epistasis genes biological_process molecular_function nucleus
YCR064C_d YCR064C YCR064C hom Dubious 0.143098899914242 0.443106036871397 no 2019 0.453343417985964 1499 NA FF Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene BUD31 Unknown Unknown Unknown
YMR230W YMR230W RPS10B hom Verified 0.142809465615606 0.443220330615578 no 2020 0.453354978754618 1501 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10B has a paralog, RPS10A, that arose from the whole genome duplication cytoplasmic translation|rRNA export from nucleus structural constituent of ribosome cytosolic small ribosomal subunit
YER161C YER161C SPT2 hom Verified 0.142186775123944 0.443466238788648 no 2021 0.446126342176656 1470 NA FT TRANSCRIPTION FROM RNA POL II|RNA PROCESSING|CHROMATIN ORGANIZATION NUCLEUS Protein involved in negative regulation of transcription; required for RNA polyadenylation; exhibits regulated interactions with both histones and SWI-SNF components, has similarity to mammalian HMG1 proteins negative regulation of transcription from RNA polymerase II promoter|chromatin organization|RNA polyadenylation|transcription elongation from RNA polymerase II promoter DNA binding|DNA secondary structure binding nucleus
YFL046W_p YFL046W FMP32 hom Uncharacterized 0.141885690875398 0.443585148495415 no 2022 0.454027755833458 1499 NA FT MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process molecular_function mitochondrion
YGL012W YGL012W ERG4 hom Verified 0.14173631229465 0.443644145706895 no 2023 0.479565687108056 1767 NA FF|FT LIPID METABOLISM|OXIDATION-REDUCTION PROCESS ENDOPLASMIC RETICULUM C-24(28) sterol reductase, catalyzes the final step in ergosterol biosynthesis; mutants are viable, but lack ergosterol ergosterol biosynthetic process delta24(24-1) sterol reductase activity integral to membrane|endoplasmic reticulum
YPR022C_p YPR022C YPR022C hom Uncharacterized 0.141673337278866 0.443669018123207 no 2024 0.451764378611598 1513 NA FT NUCLEUS Putative transcription factor, as suggested by computational analysis; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS biological_process sequence-specific DNA binding nucleus|cytoplasm
YIR032C YIR032C DAL3 hom Verified 0.141568586349539 0.443710390715867 no 2025 0.452960249810339 1498 NA FT PLASMA MEMBRANE Ureidoglycolate hydrolase, converts ureidoglycolate to glyoxylate and urea in the third step of allantoin degradation; expression sensitive to nitrogen catabolite repression allantoin catabolic process ureidoglycolate hydrolase activity membrane
YHR158C YHR158C KEL1 hom Verified 0.141099647873264 0.443895610912744 no 2026 0.422389517063713 1395 NA FT CELL CYCLE|MEMBRANE ORGANIZATION SITE OF POLARIZED GROWTH Protein required for proper cell fusion and cell morphology; functions in a complex with Kel2p to negatively regulate mitotic exit, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential Cdc28p substrate negative regulation of exit from mitosis|regulation of cell shape|cell morphogenesis|cytogamy|plasma membrane fusion molecular_function mating projection tip|cellular bud neck|cytoplasm|cellular bud tip
YNL336W YNL336W COS1 hom Verified 0.140677431443353 0.444062387433784 no 2027 0.439263894085091 1442 NA Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins biological_process molecular_function integral to membrane|fungal-type vacuole
YBL094C_d YBL094C YBL094C hom Dubious 0.140662088242218 0.444068448222418 no 2028 0.451406057403485 1487 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized ORF YBL095W Unknown Unknown Unknown
YFR001W YFR001W LOC1 hom Verified 0.140547262845915 0.444113806346867 no 2029 0.474586641671984 1573 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|RNA LOCALIZATION NUCLEUS Nuclear protein involved in asymmetric localization of ASH1 mRNA; binds double-stranded RNA in vitro; constituent of 66S pre-ribosomal particles; relocalizes from nucleus to cytoplasm upon DNA replication stress endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|ribosomal large subunit biogenesis|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|intracellular mRNA localization mRNA binding nucleolus|preribosome, large subunit precursor
YMR109W YMR109W MYO5 hom Verified 0.140415732064115 0.444165764302545 no 2030 0.444507980570019 1461 NA FT VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS|CELL DIVISION SITE OF POLARIZED GROWTH|CYTOSKELETON One of two type I myosins; contains proline-rich tail homology 2 (TH2) and SH3 domains; MYO5 deletion has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization bipolar cellular bud site selection|endocytosis|exocytosis|fungal-type cell wall organization|response to salt stress|receptor-mediated endocytosis|actin cortical patch localization|response to osmotic stress microfilament motor activity mating projection tip|actin cortical patch
YNL293W YNL293W MSB3 hom Verified 0.140016130443621 0.444323622841456 no 2031 0.438393652479217 1445 NA FT VESICLE-MEDIATED TRANSPORT|SIGNALING|NUCLEOTIDE METABOLISM|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH Rab GTPase-activating protein; regulates endocytosis via activation of Vps21p and Ypt7p; also acts on Ypt52p and Sec4p; also required for proper actin organization; localizes to the plasma membrane and sites of polarized growth, and a portion localizes to endosomes and vacuoles; similar to Msb4p; relocalizes from bud neck to cytoplasm upon DNA replication stress actin filament organization|exocytosis Rab GTPase activator activity incipient cellular bud site|polarisome|cellular bud tip
YGL056C YGL056C SDS23 hom Verified 0.139477500875215 0.444536416923302 no 2032 0.4421157366595 1475 NA FT CELL DIVISION NUCLEUS One of two S. cerevisiae homologs (Sds23p and Sds24p) of the S. pombe Sds23 protein, which is implicated in APC/cyclosome regulation; involved in cell separation during budding; SDS23 has a paralog, SDS24, that arose from the whole genome duplication cytokinetic cell separation molecular_function nucleus|cytoplasm
YDL041W_d YDL041W YDL041W hom Dubious 0.139040520573247 0.444709064612849 no 2033 0.457980502223427 1535 NA FF Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene SIR2/YDL042C Unknown Unknown Unknown
YLL025W YLL025W PAU17 hom Verified 0.138038985492267 0.445104803246434 no 2034 0.431715038916538 1422 NA Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions; YLL025W is not an essential gene biological_process molecular_function cellular_component
YOL041C YOL041C NOP12 hom Verified 0.137182733750598 0.445443179172969 no 2035 0.427988047221726 1402 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Nucleolar protein involved in pre-25S rRNA processing and biogenesis of large 60S ribosomal subunit; contains an RNA recognition motif (RRM); binds to Ebp2; similar to Nop13p and Nsr1p maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) RNA binding nucleolus|preribosome
YKL072W YKL072W STB6 hom Verified 0.137031734521143 0.445502855595081 no 2036 0.412991073613239 1346 NA Protein that binds Sin3p in a two-hybrid assay biological_process molecular_function cellular_component
YOL114C_p YOL114C YOL114C hom Uncharacterized 0.13669677141521 0.445635240806966 no 2037 0.461182655026935 1528 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION Putative protein of unknown function with similarity to human ICT1 and prokaryotic factors that may function in translation termination; YOL114C is not an essential gene biological_process molecular_function cellular_component
YJL148W YJL148W RPA34 hom Verified 0.136677729570122 0.445642766769358 no 2038 0.387497614126369 1247 NA FT NUCLEUS RNA polymerase I subunit A34.5 transcription elongation from RNA polymerase I promoter|transcription of nuclear large rRNA transcript from RNA polymerase I promoter molecular_function DNA-directed RNA polymerase I complex|nucleolus|nucleus
YMR030W YMR030W RSF1 hom Verified 0.136475911314076 0.445722533173977 no 2039 0.430902319556082 1427 NA FT TRANSCRIPTION FROM RNA POL II|SIGNALING|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY NUCLEUS|MITOCHONDRION Protein required for respiratory growth; localized to both the nucleus and mitochondrion; may interact with transcription factors to mediate the transition to respiratory growth and activate transcription of nuclear and mitochondrial genes transcription from mitochondrial promoter|calcium-mediated signaling|transcription from RNA polymerase II promoter|aerobic respiration molecular_function mitochondrion|nucleus
YJR059W YJR059W PTK2 hom Verified 0.13635916820893 0.445768675581586 no 2040 0.454359916276569 1507 NA FF|FT CELL CYCLE|ION HOMEOSTASIS|PROTEIN PHOSPHORYLATION|ION HOMEOSTASIS NUCLEUS|PLASMA MEMBRANE Putative serine/threonine protein kinase involved in regulation of ion transport across plasma membrane; enhances spermine uptake protein phosphorylation|cellular ion homeostasis|polyamine transport|G1/S transition of mitotic cell cycle|regulation of cell size protein kinase activity nucleus|plasma membrane|cytoplasm
YOR175C YOR175C ALE1 hom Verified 0.135320611614434 0.446179194626831 no 2041 0.449824645417222 1499 NA FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Broad-specificity lysophospholipid acyltransferase, part of MBOAT family of membrane-bound O-acyltransferases; key component of Lands cycle; may have role in fatty acid exchange at sn-2 position of mature glycerophospholipids glycerophospholipid biosynthetic process 1-acylglycerophosphocholine O-acyltransferase activity|O-acyltransferase activity|1-acylglycerol-3-phosphate O-acyltransferase activity integral to membrane|ribosome|endoplasmic reticulum
YNL202W YNL202W SPS19 hom Verified 0.135213552408372 0.446221516112126 no 2042 0.459432205211733 1526 NA FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS Peroxisomal 2,4-dienoyl-CoA reductase, auxiliary enzyme of fatty acid beta-oxidation; homodimeric enzyme required for growth and sporulation on petroselineate medium; expression induced during late sporulation and in the presence of oleate fatty acid catabolic process|ascospore formation 2,4-dienoyl-CoA reductase (NADPH) activity peroxisomal matrix
YJR133W YJR133W XPT1 hom Verified 0.1351495908904 0.44624680097873 no 2043 0.458936148463454 1495 NA FT NUCLEOTIDE METABOLISM Xanthine-guanine phosphoribosyl transferase, required for xanthine utilization and for optimal utilization of guanine XMP salvage|hypoxanthine metabolic process xanthine phosphoribosyltransferase activity|hypoxanthine phosphoribosyltransferase activity cytoplasm
YDR125C YDR125C ECM18 hom Verified 0.134969290758809 0.446318077273412 no 2044 0.446555882887894 1453 NA FT CELL WALL ORG/BIOGENESIS MITOCHONDRION Protein of unknown function; ECM18 has a paralog, ICT1, that arose from the whole genome duplication fungal-type cell wall organization molecular_function mitochondrion
YOR364W_d YOR364W YOR364W hom Dubious 0.134853315224029 0.446363925668667 no 2045 0.436422487622178 1433 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR365C Unknown Unknown Unknown
YER176W YER176W ECM32 hom Verified 0.133789642357053 0.446784458880243 no 2046 0.429126210318782 1414 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION DNA dependent ATPase/DNA helicase belonging to the Dna2p- and Nam7p-like family of helicases that is involved in modulating translation termination; interacts with the translation termination factors, localized to polysomes regulation of translational termination RNA helicase activity|DNA helicase activity polysome
YMR256C YMR256C COX7 hom Verified 0.133520720370855 0.446890789248978 no 2047 0.454897967871461 1490 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Subunit VII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain mitochondrial electron transport, cytochrome c to oxygen cytochrome-c oxidase activity mitochondrion|integral to membrane|mitochondrial respiratory chain complex IV
YDL242W_d YDL242W YDL242W hom Dubious 0.133507782651661 0.446895904852855 no 2048 0.434904119216097 1418 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YDL185W YDL185W VMA1 hom Verified 0.133145913607193 0.447038992280844 no 2049 0.476135116466335 1563 NA FF|FT ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS ENDOMEMBRANE SYSTEM Subunit A of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase; protein precursor undergoes self-catalyzed splicing to yield the extein Tfp1p and the intein Vde (PI-SceI), which is a site-specific endonuclease intron homing|cellular protein metabolic process|vacuolar acidification endodeoxyribonuclease activity|proton-transporting ATPase activity, rotational mechanism vacuolar proton-transporting V-type ATPase, V1 domain|fungal-type vacuole membrane
YGR187C YGR187C HGH1 hom Verified 0.132942710303393 0.447119344366185 no 2050 0.455534131855915 1482 NA Nonessential protein of unknown function; predicted to be involved in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; similar to mammalian BRP16 (Brain protein 16); relative distribution to the nucleus increases upon DNA replication stress biological_process molecular_function cytoplasm
YAL013W YAL013W DEP1 hom Verified 0.132432613414701 0.447321060036642 no 2051 0.458456422532377 1524 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS|CHROMOSOME Transcriptional modulator involved in regulation of structural phospholipid biosynthesis genes and metabolically unrelated genes, as well as maintenance of telomeres, mating efficiency, and sporulation positive regulation of transcription from RNA polymerase II promoter in response to heat stress|negative regulation of chromatin silencing at rDNA|regulation of transcription from RNA polymerase II promoter|histone deacetylation|negative regulation of chromatin silencing at silent mating-type cassette|negative regulation of chromatin silencing at telomere|negative regulation of transcription from RNA polymerase II promoter|regulation of DNA-dependent DNA replication initiation|Unknown molecular_function Rpd3L-Expanded complex|Rpd3L complex
YDR179W-A_p YDR179W-A YDR179W-A hom Uncharacterized 0.131624108985568 0.447640807610614 no 2052 0.454062547199075 1482 NA Putative protein of unknown function biological_process molecular_function cellular_component
YNL183C YNL183C NPR1 hom Verified 0.130917371905054 0.447920336083714 no 2053 0.426232352389967 1399 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|PROTEIN PHOSPHORYLATION GOLGI APPARATUS|PLASMA MEMBRANE Protein kinase that stabilizes several plasma membrane amino acid transporters by antagonizing their ubiquitin-mediated degradation; phosphorylates Aly2p; negatively regulates Ldb19p-mediated endocytosis through phosphorylation of Ldb19p, which prevents its association with the plasma membrane; Npr1p activity is negatively regulated via phosphorylation by the TOR complex regulation of transmembrane transporter activity|regulation of nitrogen utilization|protein phosphorylation|negative regulation of endocytosis protein serine/threonine kinase activity Golgi apparatus|plasma membrane|cytoplasm
YEL054C YEL054C RPL12A hom Verified 0.130468664215161 0.448097822269098 no 2054 0.437290578611184 1447 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Ribosomal 60S subunit protein L12A; rpl12a rpl12b double mutant exhibits slow growth and slow translation; homologous to mammalian ribosomal protein L12 and bacterial L11; RPL12A has a paralog, RPL12B, that arose from the whole genome duplication cytoplasmic translation|ribosomal large subunit assembly structural constituent of ribosome cytosolic large ribosomal subunit
YBR244W YBR244W GPX2 hom Verified 0.129955248151149 0.44830091657589 no 2055 0.411874552335013 1367 NA FT OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS NUCLEUS|MITOCHONDRION Phospholipid hydroperoxide glutathione peroxidase; protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress; induced by glucose starvation; protein abundance increases in response to DNA replication stress cellular response to oxidative stress phospholipid-hydroperoxide glutathione peroxidase activity|glutathione peroxidase activity extrinsic to mitochondrial inner membrane|extrinsic to mitochondrial outer membrane|nucleus|cytoplasm
YOR061W YOR061W CKA2 hom Verified 0.129687361539155 0.448406891073827 no 2056 0.454724216944301 1511 NA FF|FT RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION NUCLEUS Alpha' catalytic subunit of casein kinase 2 (CK2); CK2 is a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases; protein abundance increases in response to DNA replication stress; regulates Fkh1p-mediated donor preference during mating-type switching regulation of transcription from RNA polymerase I promoter|chronological cell aging|protein phosphorylation|regulation of transcription from RNA polymerase III promoter|response to DNA damage stimulus protein serine/threonine kinase activity protein kinase CK2 complex|UTP-C complex
YGR149W_p YGR149W YGR149W hom Uncharacterized 0.129309624315223 0.448556328135227 no 2057 0.443352879656066 1450 NA Putative protein of unknown function; predicted to be an integal membrane protein biological_process molecular_function integral to membrane
YEL046C YEL046C GLY1 hom Verified 0.12924068239368 0.448583603117107 no 2058 0.465133456381468 1530 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Threonine aldolase, catalyzes the cleavage of L-allo-threonine and L-threonine to glycine; involved in glycine biosynthesis threonine catabolic process|glycine biosynthetic process threonine aldolase activity|L-allo-threonine aldolase activity cytosol
YMR175W-A_p YMR175W-A YMR175W-A hom Uncharacterized 0.129169945013773 0.448611588675481 no 2059 0.426605258750141 1424 NA Putative protein of unknown function biological_process molecular_function cellular_component
YOL132W YOL132W GAS4 hom Verified 0.12916038289769 0.448615371718424 no 2060 0.442495484316127 1453 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM PLASMA MEMBRANE 1,3-beta-glucanosyltransferase, involved with Gas2p in spore wall assembly; has similarity to Gas1p; localizes to the cell wall ascospore wall assembly 1,3-beta-glucanosyltransferase activity fungal-type cell wall|integral to membrane
YNR064C YNR064C YNR064C hom Verified 0.128345257325031 0.448937875535958 no 2061 0.447450801222576 1492 NA Epoxide hydrolase, member of the alpha/beta hydrolase fold family; may have a role in detoxification of epoxides response to toxin epoxide hydrolase activity cellular_component
YDR277C YDR277C MTH1 hom Verified 0.128290345288639 0.44895960265714 no 2062 0.452859209967202 1505 NA FT SIGNALING Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation glucose transport|signal transduction molecular_function cellular_component
YOL065C YOL065C INP54 hom Verified 0.128058789367475 0.449051224390675 no 2063 0.435905966798341 1426 NA FT PROTEIN LOCALIZATION|LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Phosphatidylinositol 4,5-bisphosphate 5-phosphatase with a role in secretion, localizes to the endoplasmic reticulum via the C-terminal tail; lacks the Sac1 domain and proline-rich region found in the other 3 INP proteins phosphatidylinositol dephosphorylation phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity endoplasmic reticulum
YOR032C YOR032C HMS1 hom Verified 0.12757415980554 0.449242990747764 no 2064 0.452718889724454 1512 NA FT NUCLEUS Basic helix-loop-helix (bHLH) protein with similarity to myc-family transcription factors; overexpression confers hyperfilamentous growth and suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant pseudohyphal growth sequence-specific DNA binding transcription factor activity cellular_component
YBL022C YBL022C PIM1 hom Verified 0.127488469155566 0.449276899496851 no 2065 0.476925324460863 1601 NA FF|FT PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS|MITOCHONDRION ORGANIZATION|RESPONSE TO OXIDATIVE STRESS MITOCHONDRION ATP-dependent Lon protease, involved in degradation of misfolded proteins in mitochondria; required for biogenesis and maintenance of mitochondria chaperone-mediated protein complex assembly|misfolded or incompletely synthesized protein catabolic process ATP-dependent peptidase activity mitochondrion|mitochondrial matrix
YHR139C-A_d YHR139C-A YHR139C-A hom Dubious 0.126788658438184 0.449553836272742 no 2066 0.449712896629885 1531 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YLR092W YLR092W SUL2 hom Verified 0.125457291128949 0.450080767286833 no 2067 0.45521899667084 1508 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE High affinity sulfate permease; sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p, which control the concentration of endogenous activated sulfate intermediates sulfate transport sulfate transmembrane transporter activity integral to membrane|plasma membrane
YPL173W YPL173W MRPL40 hom Verified 0.125117504476166 0.450215262811532 no 2068 0.464524834620021 1551 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YNL070W YNL070W TOM7 hom Verified 0.12489502550462 0.450303328303876 no 2069 0.467112874799412 1575 NA FF|FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex protein import into mitochondrial matrix|protein import into mitochondrial outer membrane protein channel activity mitochondrial outer membrane|mitochondrion|integral to membrane|mitochondrial outer membrane translocase complex
YGL246C YGL246C RAI1 hom Verified 0.124893973083488 0.450303744897314 no 2070 0.43630356504074 1447 NA FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Nuclear protein with decapping endonuclease activity targeted toward mRNAs with unmethylated 7-methylguanosine cap structures; binds to and stabilizes the exoribonuclease Rat1p; required for pre-rRNA processing; homologous to human DOM3Z deadenylation-dependent decapping of nuclear-transcribed mRNA|maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|termination of RNA polymerase II transcription, poly(A)-coupled|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) enzyme regulator activity|m7G(5')pppN diphosphatase activity nucleus
YCR065W YCR065W HCM1 hom Verified 0.123839710005684 0.450721094882564 no 2071 0.448178087769216 1495 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION|RESPONSE TO OXIDATIVE STRESS NUCLEUS|CHROMOSOME Forkhead transcription factor that drives S-phase specific expression of genes involved in chromosome segregation, spindle dynamics, and budding; suppressor of calmodulin mutants with specific SPB assembly defects; telomere maintenance role positive regulation of transcription involved in S-phase of mitotic cell cycle|cellular response to oxidative stress|mitochondrion organization|spindle pole body organization|positive regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding nuclear chromatin|nucleus|cytoplasm
YGL033W YGL033W HOP2 hom Verified 0.123693051660765 0.450779156690943 no 2072 0.456694390168386 1505 NA FF|FT CELL CYCLE NUCLEUS|CHROMOSOME Meiosis-specific protein that localizes to chromosomes, preventing synapsis between nonhomologous chromosomes and ensuring synapsis between homologs; complexes with Mnd1p to promote homolog pairing and meiotic double-strand break repair synapsis|reciprocal meiotic recombination protein binding|double-stranded DNA binding condensed nuclear chromosome
YPR174C YPR174C YPR174C hom Verified 0.123590859314926 0.450819615102882 no 2073 0.443750890069231 1480 NA FT ENDOMEMBRANE SYSTEM|NUCLEUS|CYTOSKELETON Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nuclear periphery; potential Cdc28p substrate; binds phosphatidylinositols and phosphatidylethanolamine in a large-scale study; relative distribution to foci at the nuclear periphery increases upon DNA replication stress; YPR174C has a paralog, NBP1, that arose from the whole genome duplication biological_process molecular_function nuclear envelope|spindle pole body
YJL067W_d YJL067W YJL067W hom Dubious 0.12298412783722 0.451059833348227 no 2074 0.442565882384109 1458 NA Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YOR090C YOR090C PTC5 hom Verified 0.122398338350068 0.451291777210974 no 2075 0.459032828378164 1542 NA FT MITOCHONDRION Mitochondrial type 2C protein phosphatase (PP2C) involved in regulation of pyruvate dehydrogenase activity by dephosphorylating the serine 133 of the Pda1p subunit; localizes to the intermembrane space and is imported via the presequence pathway and processed by the inner membrane protease (Imp1p-Imp2p); acts in concert with kinases Pkp1p and Pkp2p and phosphatase Ptc6p positive regulation of catalytic activity|regulation of catalytic activity|protein dephosphorylation [pyruvate dehydrogenase (lipoamide)] phosphatase activity|protein serine/threonine phosphatase activity mitochondrion
YAR031W YAR031W PRM9 hom Verified 0.122207891125831 0.451367188543119 no 2076 0.446734538555779 1485 NA FT VESICLE-MEDIATED TRANSPORT ENDOPLASMIC RETICULUM|PLASMA MEMBRANE Pheromone-regulated protein with 3 predicted transmembrane segments and an FF sequence, a motif involved in COPII binding; member of DUP240 gene family vesicle organization molecular_function integral to membrane|endoplasmic reticulum|plasma membrane
YOL042W YOL042W NGL1 hom Verified 0.122024709071548 0.451439724744057 no 2077 0.447296163261674 1482 NA FT MITOCHONDRION Putative endonuclease, has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process endonuclease activity mitochondrion
YGL161C YGL161C YIP5 hom Verified 0.121608564835842 0.45160451504031 no 2078 0.45021554511996 1478 NA FT GOLGI APPARATUS Protein that interacts with Rab GTPases, localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport biological_process Rab GTPase binding integral to membrane|Golgi apparatus
YGL027C YGL027C CWH41 hom Verified 0.12143243876786 0.451674262282632 no 2079 0.458801571632675 1522 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Processing alpha glucosidase I, ER type II integral membrane N-glycoprotein involved in assembly of cell wall beta 1,6 glucan and asparagine-linked protein glycosylation; also involved in ER protein quality control and sensing of ER stress fungal-type cell wall biogenesis|protein N-linked glycosylation mannosyl-oligosaccharide glucosidase activity endoplasmic reticulum membrane
YGR289C YGR289C MAL11 hom Verified 0.118621939709975 0.452787441351234 no 2080 0.460289302014939 1529 NA FT CARBOHYDRATE METABOLISM PLASMA MEMBRANE Inducible high-affinity maltose transporter (alpha-glucoside transporter); encoded in the MAL1 complex locus; broad substrate specificity that includes maltotriose; required for isomaltose utilization trehalose transport|maltose transport|disaccharide catabolic process trehalose transmembrane transporter activity|alpha-glucoside:hydrogen symporter activity|maltose:hydrogen symporter activity integral to membrane|plasma membrane
YMR055C YMR055C BUB2 hom Verified 0.117596414484226 0.453193723030537 no 2081 0.453115867281795 1493 NA FT CELL CYCLE|SIGNALING|CELL DIVISION|NUCLEOTIDE METABOLISM CYTOSKELETON Mitotic exit network regulator, forms GTPase-activating Bfa1p-Bub2p complex that binds Tem1p and spindle pole bodies, blocks cell cycle progression before anaphase in response to spindle and kinetochore damage regulation of exit from mitosis|mitotic cell cycle spindle orientation checkpoint GTPase activator activity spindle pole body
YPL001W YPL001W HAT1 hom Verified 0.116952109574256 0.453449001988548 no 2082 0.460367096363785 1554 NA FT CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING NUCLEUS HISTONE ACETYLTRANSFERASE Catalytic subunit of the Hat1p-Hat2p histone acetyltransferase complex that uses the cofactor acetyl coenzyme A, to acetylate free nuclear and cytoplasmic histone H4; involved in telomeric silencing and DNA double-strand break repair histone acetylation|chromatin silencing at telomere histone acetyltransferase activity|histone binding histone acetyltransferase complex|nucleus|cytoplasm
YOR345C_d YOR345C YOR345C hom Dubious 0.116567631771746 0.453601344459303 no 2083 0.444705369296289 1456 NA Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene REV1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2 Unknown Unknown Unknown
YBL063W YBL063W KIP1 hom Verified 0.116377588186407 0.453676648362839 no 2084 0.448788735430627 1486 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION CYTOSKELETON Kinesin-related motor protein required for mitotic spindle assembly, chromosome segregation, and 2 micron plasmid partitioning; functionally redundant with Cin8p for chromosomal but not plasmid functions mitotic anaphase B|microtubule depolymerization|spindle pole body separation|plasmid partitioning|mitotic sister chromatid segregation microtubule motor activity|structural constituent of cytoskeleton spindle microtubule|kinesin complex|spindle pole body
YPL080C_d YPL080C YPL080C hom Dubious 0.116275950306575 0.453716922592682 no 2085 0.394887399346828 1324 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YDR540C YDR540C IRC4 hom Verified 0.116145613357983 0.453768569587106 no 2086 0.463989438870788 1548 NA FF|FT NUCLEUS Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus mitotic recombination molecular_function nucleus|cytoplasm
YBR101C YBR101C FES1 hom Verified 0.115696744084933 0.453946443384013 no 2087 0.453377482712481 1499 NA FT TRANSLATION RIBOSOME Hsp70 (Ssa1p) nucleotide exchange factor; cytosolic homolog of Sil1p, which is the nucleotide exchange factor for BiP (Kar2p) in the endoplasmic reticulum; protein abundance increases in response to DNA replication stress cytoplasmic translation adenyl-nucleotide exchange factor activity cytosol|cytosolic ribosome
YGR111W_p YGR111W YGR111W hom Uncharacterized 0.115431710401757 0.454051472839875 no 2088 0.474614777458108 1579 NA FT NUCLEUS Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus regulation of cell size molecular_function nucleus|cytoplasm
YLR139C YLR139C SLS1 hom Verified 0.115026585332087 0.454212024926186 no 2089 0.458521469278606 1525 NA FT TRANSLATION|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Mitochondrial membrane protein that coordinates expression of mitochondrially-encoded genes; may facilitate delivery of mRNA to membrane-bound translation machinery aerobic respiration|mitochondrial translation molecular_function mitochondrial nucleoid|mitochondrion|integral to membrane|mitochondrial inner membrane
YJL130C YJL130C URA2 hom Verified 0.114316935164659 0.454493279092357 no 2090 0.439425544097543 1418 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEOTIDE METABOLISM MITOCHONDRION Bifunctional carbamoylphosphate synthetase (CPSase)-aspartate transcarbamylase (ATCase), catalyzes the first two enzymatic steps in the de novo biosynthesis of pyrimidines; both activities are subject to feedback inhibition by UTP glutamine metabolic process|'de novo' pyrimidine nucleobase biosynthetic process|negative regulation of pyrimidine nucleobase metabolic process aspartate carbamoyltransferase activity|carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity mitochondrion|integral to membrane|cytoplasm
YPL058C YPL058C PDR12 hom Verified 0.114264022084038 0.454514250938722 no 2091 0.455882340334086 1499 NA FT KETONE METABOLISM|NUCLEOTIDE METABOLISM PLASMA MEMBRANE Plasma membrane ATP-binding cassette (ABC) transporter, weak-acid-inducible multidrug transporter required for weak organic acid resistance; induced by sorbate and benzoate and regulated by War1p; mutants exhibit sorbate hypersensitivity propionate metabolic process|transport|organic acid transport xenobiotic-transporting ATPase activity|organic acid transmembrane transporter activity integral to membrane|plasma membrane
YPL257W_p YPL257W YPL257W hom Uncharacterized 0.114237680379012 0.454524691394766 no 2092 0.423547306646261 1386 NA FT CELL CYCLE Putative protein of unknown function; homozygous diploid deletion strain exhibits low budding index; physically interacts with Hsp82p; YPL257W is not an essential gene biological_process molecular_function integral to membrane
YKL010C YKL010C UFD4 hom Verified 0.113921090629187 0.454650173251556 no 2093 0.458955072511536 1501 NA FT PROTEOLYSIS MITOCHONDRION Ubiquitin-protein ligase (E3); interacts with Rpt4p and Rpt6p, two subunits of the 19S particle of the 26S proteasome; cytoplasmic E3 involved