strainid orf gene zyg qualifier SGTC_3217|9129673.score SGTC_3217|9129673.expt.zyg.pval SGTC_3217|9129673.expt.zyg.significant SGTC_3217|9129673.expt.zyg.rank strain.pval strain.rank clearance Fclass Fterms.BP Fterms.CC Fterms.complex description GO_process GO_function GO_component
YIL053W YIL053W RHR2 hom Verified 7.27481823884049 1.73443595834554e-13 yes 1 5.73811610837991e-11 3 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY NUCLEUS Constitutively expressed glycerol-1-phosphatase; involved in glycerol biosynthesis, induced in response to both anaerobic and osmotic stress; RHR2 has a paralog, HOR2, that arose from the whole genome duplication glycerol biosynthetic process|response to osmotic stress glycerol-1-phosphatase activity nucleus|cytoplasm
YJL110C YJL110C GZF3 hom Verified 7.16113994867893 4.00044581499297e-13 yes 2 1.66847360863791e-11 3 NA FT PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS NUCLEUS GATA zinc finger protein; negatively regulates nitrogen catabolic gene expression by competing with Gat1p for GATA site binding; function requires a repressive carbon source; dimerizes with Dal80p and binds to Tor1p; GZF3 has a paralog, DAL80, that arose from the whole genome duplication maintenance of protein location in nucleus|nitrogen catabolite repression of transcription|negative regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding RNA polymerase II transcription factor activity|sequence-specific DNA binding nucleus
YCL056C YCL056C PEX34 hom Verified 6.67115626938788 1.26897897896071e-11 yes 3 3.91321812553935e-11 2 NA FT PEROXISOME ORGANIZATION Peroxisomal integral membrane protein that regulates peroxisome populations; interacts with Pex11p, Pex25p, and Pex27p to control both constitutive peroxisome division and peroxisome morphology and abundance during peroxisome proliferation peroxisome organization molecular_function integral to peroxisomal membrane|cytoplasm
YPL195W YPL195W APL5 hom Verified 6.44435610325337 5.80461092564403e-11 yes 4 5.07438748918746e-09 8 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Delta adaptin-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway, suppressor of loss of casein kinase 1 function vesicle-mediated transport|Golgi to vacuole transport protein binding AP-3 adaptor complex
YLR307C-A_p YLR307C-A YLR307C-A hom Uncharacterized 6.2593410628626 1.93303761014976e-10 yes 5 3.08060599788055e-12 2 NA Putative protein of unknown function biological_process molecular_function cellular_component
YMR194W YMR194W RPL36A hom Verified 6.04590957546749 7.42847048696765e-10 yes 6 1.78095732345764e-10 3 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L36A; N-terminally acetylated; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L36, no bacterial homolog; RPL36A has a paralog, RPL36B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome|RNA binding cytosolic large ribosomal subunit
YLR453C YLR453C RIF2 hom Verified 5.3657639678486 4.03036484632499e-08 yes 7 1.11205687701298e-08 5 NA FT NUCLEUS|CHROMOSOME Protein that binds to the Rap1p C-terminus and acts synergistically with Rif1p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation telomere capping|telomere maintenance via telomerase telomeric DNA binding nuclear telomere cap complex
YBR007C YBR007C DSF2 hom Verified 5.20760010238018 9.56493213245198e-08 yes 8 2.98356758017259e-07 20 NA FF Deletion suppressor of mpt5 mutation; relocalizes from bud neck to cytoplasm upon DNA replication stress biological_process molecular_function cellular_component
YHR106W YHR106W TRR2 hom Verified 5.06846835616513 2.00514817897779e-07 yes 9 5.27762291062718e-08 2 NA FT OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS MITOCHONDRION Mitochondrial thioredoxin reductase; involved in protection against oxidative stress, required with Glr1p to maintain the redox state of Trx3p; contains active-site motif (CAVC) present in prokaryotic orthologs; binds NADPH and FAD; TRR2 has a paralog, TRR1, that arose from the whole genome duplication cellular response to oxidative stress|cell redox homeostasis thioredoxin-disulfide reductase activity mitochondrion
YLR200W YLR200W YKE2 hom Verified 5.00185871339934 2.83900989143406e-07 yes 10 8.62845069838766e-06 30 NA FF|FT PROTEIN COMPLEX ORG/BIOGENESIS NUCLEUS Subunit of the heterohexameric Gim/prefoldin protein complex involved in the folding of alpha-tubulin, beta-tubulin, and actin protein folding|tubulin complex assembly tubulin binding prefoldin complex|cytoplasm
YBL104C YBL104C SEA4 hom Verified 4.98134038183611 3.15726786463935e-07 yes 11 6.77779731539823e-07 13 NA Subunit of the SEA (Seh1-associated) complex, a coatomer-related complex that associates dynamically with the vacuole; has an N-terminal beta-propeller fold and a C-terminal RING motif; promoter contains multiple GCN4 binding sites biological_process molecular_function Seh1-associated complex|extrinsic to fungal-type vacuolar membrane|cytoplasm
YPR060C YPR060C ARO7 hom Verified 4.93195096743576 4.07061777440229e-07 yes 12 1.54007089810496e-05 50 NA FF|FT KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS Chorismate mutase, catalyzes the conversion of chorismate to prephenate to initiate the tyrosine/phenylalanine-specific branch of aromatic amino acid biosynthesis aromatic amino acid family biosynthetic process chorismate mutase activity nucleus|cytoplasm
YNL094W YNL094W APP1 hom Verified 4.79955113126659 7.95108172121829e-07 yes 13 1.05408231652494e-06 7 NA FT CYTOSKELETON ORGANIZATION CYTOSKELETON Phosphatidate phosphatase, converts phosphatidate to diacylglycerol; App1p, Pah1p, Dpp1p, and Lpp1p are responsible for all the phosphatidate phosphatase activity; component of cortical actin patches; interacts with components of endocytic pathway actin cytoskeleton organization molecular_function actin cytoskeleton|actin cortical patch
YGL020C YGL020C GET1 hom Verified 4.79111229188572 8.29296317648978e-07 yes 14 1.48520275706894e-05 28 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION|GOLGI APPARATUS Subunit of the GET complex; involved in insertion of proteins into the ER membrane; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for normal mitochondrial morphology and inheritance retrograde vesicle-mediated transport, Golgi to ER|protein insertion into ER membrane protein anchor mitochondrion|integral to membrane|endoplasmic reticulum|GET complex
YMR067C YMR067C UBX4 hom Verified 4.76682336524379 9.35766244755479e-07 yes 15 6.05202024190621e-06 35 NA FT PROTEOLYSIS NUCLEUS UBX domain-containing protein that interacts with Cdc48p; involved in degradation of polyubiquitinated proteins via the ERAD (ER-associated degradation) pathway; modulates the Cdc48p-Nplp-Ufd1p AAA ATPase complex during its role in delivery of misfolded proteins to the proteasome; protein abundance increases in response to DNA replication stress ER-associated protein catabolic process|sporulation resulting in formation of a cellular spore protein complex binding nucleus|cytoplasm|extrinsic to membrane
YGR247W YGR247W CPD1 hom Verified 4.64628010865649 1.68987011520402e-06 yes 16 6.61492135544793e-07 4 NA FT NUCLEOTIDE METABOLISM GOLGI APPARATUS Cyclic nucleotide phosphodiesterase; hydrolyzes ADP-ribose 1'', 2''-cyclic phosphate to ADP-ribose 1''-phosphate; may have a role in tRNA splicing; no detectable phenotype is conferred by null mutation or by overexpression; protein abundance increases in response to DNA replication stress cyclic nucleotide metabolic process 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity clathrin-coated vesicle
YDL197C YDL197C ASF2 hom Verified 4.64115451199619 1.73233961837527e-06 yes 17 7.95364572885232e-08 3 NA FT GENE SILENCING NUCLEUS|CHROMOSOME Anti-silencing protein that causes derepression of silent loci when overexpressed chromatin silencing at silent mating-type cassette molecular_function nuclear chromosome, telomeric region|nucleus
YFL042C_p YFL042C YFL042C hom Uncharacterized 4.60181353313659 2.0941404386271e-06 yes 18 3.2336078217196e-06 6 NA Putative protein of unknown function; YFL042C is not an essential gene biological_process molecular_function cellular_component
YCR047C YCR047C BUD23 hom Verified 4.57352201751964 2.39796627279036e-06 yes 19 3.03046536636616e-06 8 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|RIBOSOME BIOGENESIS|CELL DIVISION NUCLEUS Methyltransferase, methylates residue G1575 of 18S rRNA; required for rRNA processing and nuclear export of 40S ribosomal subunits independently of methylation activity; diploid mutant displays random budding pattern endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|rRNA (guanine-N7)-methylation|cellular bud site selection|ribosomal small subunit export from nucleus S-adenosylmethionine-dependent methyltransferase activity|rRNA (guanine) methyltransferase activity nucleolus|nucleus|cytoplasm
YMR167W YMR167W MLH1 hom Verified 4.54824419371526 2.70476725630858e-06 yes 20 2.34320260289218e-07 2 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE NUCLEUS|MITOCHONDRION|CHROMOSOME Protein required for mismatch repair in mitosis and meiosis as well as crossing over during meiosis; forms a complex with Pms1p and Msh2p-Msh3p during mismatch repair; human homolog is associated with hereditary non-polyposis colon cancer mismatch repair|meiotic mismatch repair|reciprocal meiotic recombination|meiotic heteroduplex formation double-stranded DNA binding|DNA insertion or deletion binding|loop DNA binding|single-stranded DNA binding|dinucleotide insertion or deletion binding|ATPase activity|ATP binding mitochondrion|nucleus|MutLalpha complex|MutLbeta complex|cytoplasm
YIL002C YIL002C INP51 hom Verified 4.4914761026621 3.53656191484825e-06 yes 21 2.70079893069255e-05 26 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|MEMBRANE ORGANIZATION CYTOSKELETON Phosphatidylinositol 4,5-bisphosphate 5-phosphatase, synaptojanin-like protein with an N-terminal Sac1 domain, plays a role in phosphatidylinositol 4,5-bisphosphate homeostasis and in endocytosis; null mutation confers cold-tolerant growth phosphatidylinositol dephosphorylation phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity membrane|cytoplasm
YGR284C YGR284C ERV29 hom Verified 4.43039933858211 4.70293726539472e-06 yes 22 7.50691226549472e-06 7 NA FT VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Protein localized to COPII-coated vesicles; involved in vesicle formation and incorporation of specific secretory cargo; protein abundance increases in response to DNA replication stress ER to Golgi vesicle-mediated transport molecular_function integral to membrane|ER to Golgi transport vesicle
YDL160C-A YDL160C-A MHF2 hom Verified 4.40828494249437 5.2096204414279e-06 yes 23 8.64530220390863e-06 4 NA FT RESPONSE TO DNA DAMAGE Component of the heterotetrameric MHF histone-fold complex; in humans the MMF complex interacts with both DNA and Mph1p ortholog FANCM to stabilize and remodel blocked replication forks and repair damaged DNA; mhf2 srs2 double mutants are MMS hypersensitive; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-X, also known as MHF2 response to DNA damage stimulus molecular_function cellular_component
YNL249C YNL249C MPA43 hom Verified 4.39237812383557 5.60587414589144e-06 yes 24 1.09274255052766e-05 5 NA FT CARBOHYDRATE METABOLISM MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process molecular_function mitochondrion
YDR436W YDR436W PPZ2 hom Verified 4.36308075959713 6.41217873152145e-06 yes 25 3.17572380173118e-06 7 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS Serine/threonine protein phosphatase Z, isoform of Ppz1p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance cellular sodium ion homeostasis protein serine/threonine phosphatase activity cellular_component
YDR247W YDR247W VHS1 hom Verified 4.311137691696 8.12083624158539e-06 yes 26 3.07785026232016e-07 4 NA FT CELL CYCLE|PROTEIN PHOSPHORYLATION Cytoplasmic serine/threonine protein kinase; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; homolog of Sks1p protein phosphorylation|G1/S transition of mitotic cell cycle protein serine/threonine kinase activity|protein kinase activity cytoplasm
YER150W YER150W SPI1 hom Verified 4.30474319228076 8.35897765419863e-06 yes 27 1.12043264127615e-05 11 NA GPI-anchored cell wall protein involved in weak acid resistance; basal expression requires Msn2p/Msn4p; expression is induced under conditions of stress and during the diauxic shift; similar to Sed1p response to acid molecular_function fungal-type cell wall
YCR061W_p YCR061W YCR061W hom Uncharacterized 4.28582776068696 9.103000363407e-06 yes 28 1.31530080231727e-05 18 NA Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; induced by treatment with 8-methoxypsoralen and UVA irradiation regulation of cell size molecular_function integral to membrane|cytoplasm
YDR318W YDR318W MCM21 hom Verified 4.25742766131109 1.03396270515832e-05 yes 29 6.81058689328959e-05 23 NA FT CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME KINETOCHORE Component of the kinetochore sub-complex COMA; COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) bridges kinetochore subunits in contact with centromeric DNA with subunits bound to microtubules during kinetochore assembly; involved in minichromosome maintenance; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-O and fission yeast mal2 chromosome segregation|establishment of mitotic sister chromatid cohesion molecular_function COMA complex|condensed nuclear chromosome kinetochore
YGL210W YGL210W YPT32 hom Verified 4.18335194550899 1.43621091242079e-05 yes 30 9.33011604040022e-07 7 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING ENDOMEMBRANE SYSTEM|MITOCHONDRION|GOLGI APPARATUS Rab family GTPase involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; protein abundance increases in response to DNA replication stress; YPT32 has a paralog, YPT31, that arose from the whole genome duplication early endosome to Golgi transport|vesicle-mediated transport|exocytosis GTPase activity endosome|mitochondrial outer membrane|Golgi apparatus
YDR161W_p YDR161W YDR161W hom Uncharacterized 4.18329239749268 1.43658732194949e-05 yes 31 1.70177379311249e-05 15 NA FT PROTEOLYSIS NUCLEUS Putative protein of unknown function; non-essential gene; proposed function in rRNA and ribosome biosynthesis based on transcriptional co-regulation; genetic interactions suggest a role in ER-associated protein degradation (ERAD) ER-associated protein catabolic process molecular_function nucleus|cytoplasm
YDR129C YDR129C SAC6 hom Verified 4.15948352261493 1.59484014599529e-05 yes 32 0.00607212920879012 162 NA FF|FT VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CELL DIVISION|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH|CYTOSKELETON Fimbrin, actin-bundling protein; cooperates with Scp1p (calponin/transgelin) in the organization and maintenance of the actin cytoskeleton; relocalizes from plasma membrane to cytoplasm upon DNA replication stress bipolar cellular bud site selection|actin filament organization|endocytosis|response to osmotic stress actin filament binding|protein binding, bridging actin filament bundle|mating projection tip|actin cortical patch
YDR117C YDR117C TMA64 hom Verified 4.15683792508742 1.61341369232382e-05 yes 33 2.40420649325584e-06 4 NA FT TRANSLATION Protein of unknown function that associates with ribosomes; has a putative RNA binding domain; in mammals the corresponding protein, eIF2D, has been shown to possess translation initiation factor activity biological_process RNA binding ribosome
YJL177W YJL177W RPL17B hom Verified 4.1444177472527 1.70339103679571e-05 yes 34 2.29620532089395e-05 10 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L17B; homologous to mammalian ribosomal protein L17 and bacterial L22; RPL17B has a paralog, RPL17A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YPL090C YPL090C RPS6A hom Verified 4.13345183706001 1.78677604480821e-05 yes 35 2.25524661271062e-05 19 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S6, no bacterial homolog; RPS6A has a paralog, RPS6B, that arose from the whole genome duplication cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) structural constituent of ribosome small-subunit processome|cytosolic small ribosomal subunit|90S preribosome
YGL220W YGL220W FRA2 hom Verified 4.04549001155375 2.61068960416925e-05 yes 36 4.18015433277088e-05 22 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Protein involved in negative regulation of transcription of iron regulon; forms an iron independent complex with Fra2p, Grx3p, and Grx4p; null mutant fails to repress iron regulon and is sensitive to nickel negative regulation of transcription from RNA polymerase II promoter in response to iron molecular_function cytosol|nucleus|cytoplasm
YDR352W YDR352W YPQ2 hom Verified 3.99695686136614 3.20809939385046e-05 yes 37 3.32683070750544e-06 5 NA Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; member of the PQ-loop family, with seven transmembrane domains; mutant phenotype is functionally complemented by rat PQLC2 vacuolar transporter biological_process molecular_function fungal-type vacuole membrane|integral to membrane
YGR169C-A_p YGR169C-A YGR169C-A hom Uncharacterized 3.95096613473156 3.89181695158512e-05 yes 38 2.28558155766781e-05 13 NA Putative protein of unknown function; YGR169C-A has a paralog, YJR005C-A, that arose from the whole genome duplication biological_process molecular_function cellular_component
YLR292C YLR292C SEC72 hom Verified 3.94960511778789 3.91401139514581e-05 yes 39 0.000139667181779784 33 NA FT PROTEIN LOCALIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER posttranslational protein targeting to membrane, translocation protein transporter activity Sec62/Sec63 complex|endoplasmic reticulum membrane
YAL016C-B_d YAL016C-B YAL016C-B hom Dubious 3.90685825705413 4.67519834278797e-05 yes 40 1.53412591759329e-05 7 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YBR063C_p YBR063C YBR063C hom Uncharacterized 3.89619375519915 4.88581135404928e-05 yes 41 1.58519457255439e-05 5 NA Putative protein of unknown function; YBR063C is not an essential gene biological_process molecular_function cellular_component
YML068W YML068W ITT1 hom Verified 3.88853781768611 5.04249789806696e-05 yes 42 7.20633147143522e-06 12 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION Protein that modulates the efficiency of translation termination, interacts with translation release factors eRF1 (Sup45p) and eRF3 (Sup35p) in vitro, contains a zinc finger domain characteristic of the TRIAD class of proteins regulation of translational termination molecular_function cellular_component
YNL107W YNL107W YAF9 hom Verified 3.8652832662741 5.54801720808692e-05 yes 43 0.000344846682979154 53 NA FF|FT CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING NUCLEUS|CHROMOSOME HISTONE ACETYLTRANSFERASE Subunit of both the NuA4 histone H4 acetyltransferase complex and the SWR1 complex, may function to antagonize silencing near telomeres; interacts directly with Swc4p, has homology to human leukemogenic protein AF9, contains a YEATS domain DNA repair|chromatin remodeling|histone exchange|chromatin silencing at telomere molecular_function Swr1 complex|nucleus|NuA4 histone acetyltransferase complex|cytoplasm
YPR147C_p YPR147C YPR147C hom Uncharacterized 3.85311849388153 5.83114578924561e-05 yes 44 0.000118377466823994 13 NA Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS biological_process molecular_function cytoplasm
YBR085C-A YBR085C-A YBR085C-A hom Verified 3.80750534543863 7.01878529081004e-05 yes 45 8.57991911872391e-06 12 NA FT NUCLEUS Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus; protein abundance increases in response to DNA replication stress biological_process molecular_function nucleus|cytoplasm
YMR171C YMR171C EAR1 hom Verified 3.72888267386095 9.61653341526531e-05 yes 46 6.24750725658215e-05 9 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEOLYSIS|VACUOLAR TRANSPORT Specificity factor required for Rsp5p-dependent ubiquitination and sorting of specific cargo proteins at the multivesicular body; mRNA is targeted to the bud via the mRNA transport system involving She2p protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway molecular_function endosome
YGL209W YGL209W MIG2 hom Verified 3.72409283033614 9.80093972187268e-05 yes 47 4.54484229465623e-05 7 NA FT TRANSCRIPTION FROM RNA POL II|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS NUCLEUS|MITOCHONDRION Zinc finger transcriptional repressor; cooperates with Mig1p in glucose-induced repression of many genes; under low glucose conditions Mig2p relocalizes to mitochondrion, where it interacts with Ups1p and antagonizes mitochondrial fission factor, Dnm1p, indicative of a role in mitochondrial fusion or regulating morphology; regulates filamentous growth along with Mig2p in response to glucose depletion; MIG2 has a paralog, MIG3, that arose from the whole genome duplication negative regulation of transcription from RNA polymerase II promoter by glucose|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding mitochondrion|nucleus
YMR030W YMR030W RSF1 hom Verified 3.69630511641446 0.000109380021040807 yes 48 4.54321184524297e-05 16 NA FT TRANSCRIPTION FROM RNA POL II|SIGNALING|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY NUCLEUS|MITOCHONDRION Protein required for respiratory growth; localized to both the nucleus and mitochondrion; may interact with transcription factors to mediate the transition to respiratory growth and activate transcription of nuclear and mitochondrial genes transcription from mitochondrial promoter|calcium-mediated signaling|transcription from RNA polymerase II promoter|aerobic respiration molecular_function mitochondrion|nucleus
YBR108W YBR108W AIM3 hom Verified 3.69588656598592 0.000109560398560375 yes 49 4.89304416490727e-05 8 NA FT CYTOSKELETON ORGANIZATION CYTOSKELETON Protein interacting with Rvs167p; null mutant is viable and displays elevated frequency of mitochondrial genome loss actin cortical patch assembly molecular_function membrane raft|actin cortical patch
YOR022C_p YOR022C YOR022C hom Uncharacterized 3.68576087808761 0.000114010186074318 yes 50 6.32305786506049e-05 20 NA FT LIPID METABOLISM MITOCHONDRION Putative carboxylic ester hydrolase; similar to bovine phospholipase A1; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process phospholipase activity mitochondrion
YHR158C YHR158C KEL1 hom Verified 3.68207939730749 0.000115669667420851 yes 51 0.000163598877049928 25 NA FT CELL CYCLE|MEMBRANE ORGANIZATION SITE OF POLARIZED GROWTH Protein required for proper cell fusion and cell morphology; functions in a complex with Kel2p to negatively regulate mitotic exit, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential Cdc28p substrate negative regulation of exit from mitosis|regulation of cell shape|cell morphogenesis|cytogamy|plasma membrane fusion molecular_function mating projection tip|cellular bud neck|cytoplasm|cellular bud tip
YGL117W_p YGL117W YGL117W hom Uncharacterized 3.64065771931864 0.000135971230693797 yes 52 0.00161982688501176 120 NA FF Putative protein of unknown function biological_process molecular_function cellular_component
YIR001C YIR001C SGN1 hom Verified 3.62506679436245 0.00014444338824377 yes 53 9.07749741830148e-05 9 NA Cytoplasmic RNA-binding protein, contains an RNA recognition motif (RRM); may have a role in mRNA translation, as suggested by genetic interactions with genes encoding proteins involved in translational initiation mRNA metabolic process poly(A) RNA binding cytoplasm
YDR253C YDR253C MET32 hom Verified 3.61585984098534 0.000149676160432935 yes 54 0.000329980132578858 45 NA FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|CELL CYCLE|AMINO ACID METABOLISM NUCLEUS Zinc-finger DNA-binding transcription factor; involved in transcriptional regulation of the methionine biosynthetic genes; MET32 has a paralog, MET31, that arose from the whole genome duplication regulation of mitotic cell cycle|regulation of sulfur amino acid metabolic process|regulation of transcription from RNA polymerase II promoter core promoter proximal region sequence-specific DNA binding|RNA polymerase II activating transcription factor binding|sequence-specific DNA binding|sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity nucleus|cytoplasm
YPL061W YPL061W ALD6 hom Verified 3.61035672846192 0.000152888084205152 yes 55 0.000607079144169426 60 NA FT KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM MITOCHONDRION Cytosolic aldehyde dehydrogenase, activated by Mg2+ and utilizes NADP+ as the preferred coenzyme; required for conversion of acetaldehyde to acetate; constitutively expressed; locates to the mitochondrial outer surface upon oxidative stress response to salt stress|NADPH regeneration|acetate biosynthetic process aldehyde dehydrogenase [NAD(P)+] activity cytosol|mitochondrion
YDR272W YDR272W GLO2 hom Verified 3.56028395236129 0.000185226996441767 yes 56 0.000112088481761995 20 NA FT KETONE METABOLISM|CARBOHYDRATE METABOLISM Cytoplasmic glyoxalase II, catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate cellular carbohydrate metabolic process|methylglyoxal catabolic process to D-lactate hydroxyacylglutathione hydrolase activity cytoplasm
YNR052C YNR052C POP2 hom Verified 3.53304553465933 0.000205400855149522 yes 57 0.00286773960106948 91 NA FF|FT TRANSCRIPTION FROM RNA POL II|RNA PROCESSING NUCLEUS|SITE OF POLARIZED GROWTH RNase of the DEDD superfamily, subunit of the Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation regulation of transcription from RNA polymerase II promoter|positive regulation of transcription elongation from RNA polymerase II promoter|nuclear-transcribed mRNA poly(A) tail shortening|transcription elongation from RNA polymerase II promoter 3'-5'-exoribonuclease activity CCR4-NOT core complex|mating projection tip|cytoplasmic mRNA processing body|cytoplasm
YJL042W YJL042W MHP1 hom Verified 3.50512997746237 0.000228192207064656 yes 58 7.46078843867755e-05 6 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION CYTOSKELETON Microtubule-associated protein involved in assembly and stabilization of microtubules; overproduction results in cell cycle arrest at G2 phase; similar to Drosophila protein MAP and to mammalian MAP4 proteins fungal-type cell wall organization|negative regulation of microtubule depolymerization structural constituent of cytoskeleton microtubule
YDL211C_p YDL211C YDL211C hom Uncharacterized 3.50174429294689 0.000231111502670977 yes 59 0.000222813769474994 19 NA Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole biological_process molecular_function fungal-type vacuole
YGL135W YGL135W RPL1B hom Verified 3.49129513760339 0.000240342470516634 yes 60 0.000158357949932137 15 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L1B; N-terminally acetylated; homologous to mammalian ribosomal protein L10A and bacterial L1; RPL1B has a paralog, RPL1A, that arose from the whole genome duplication; rpl1a rpl1b double null mutation is lethal cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YPL213W YPL213W LEA1 hom Verified 3.4911557921578 0.000240467862563197 yes 61 0.000190405287157821 33 NA FT RNA PROCESSING NUCLEUS Component of U2 snRNP; disruption causes reduced U2 snRNP levels; physically interacts with Msl1p; putative homolog of human U2A' snRNP protein mRNA splicing, via spliceosome molecular_function U2 snRNP|U2-type prespliceosome|cytoplasm
YNL044W YNL044W YIP3 hom Verified 3.47293016485384 0.000257404645376146 yes 62 0.000145148404317585 14 NA FT VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS Protein localized to COPII vesicles, proposed to be involved in ER to Golgi transport; interacts with members of the Rab GTPase family and Yip1p; also interacts with Rtn1p ER to Golgi vesicle-mediated transport molecular_function Golgi apparatus|endoplasmic reticulum|ER to Golgi transport vesicle
YBR069C YBR069C TAT1 hom Verified 3.47219388109187 0.00025811168667927 yes 63 0.033897167607952 215 NA FF|FT PLASMA MEMBRANE Amino acid transporter for valine, leucine, isoleucine, and tyrosine; low-affinity tryptophan and histidine transporter; overexpression confers FK506 and FTY720 resistance; protein abundance increases in response to DNA replication stress amino acid transport|tyrosine transport|tryptophan transport|transmembrane transport amino acid transmembrane transporter activity|low-affinity tryptophan transmembrane transporter activity integral to membrane|plasma membrane
YGL087C YGL087C MMS2 hom Verified 3.43749584140566 0.000293559867500837 yes 64 0.000179806618816723 31 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RESPONSE TO DNA DAMAGE NUCLEUS Ubiquitin-conjugating enzyme variant; involved in error-free postreplication repair; forms a heteromeric complex with Ubc13p, an active ubiquitin-conjugating enzyme; cooperates with chromatin-associated RING finger proteins, Rad18p and Rad5p; protein abundance increases in response to DNA replication stress postreplication repair|response to DNA damage stimulus|protein polyubiquitination|free ubiquitin chain polymerization ubiquitin-protein ligase activity ubiquitin conjugating enzyme complex|nucleus|cytoplasm
YEL061C YEL061C CIN8 hom Verified 3.42491884770172 0.00030749154322459 yes 65 0.000570254671253828 62 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION NUCLEUS|MITOCHONDRION|CHROMOSOME|CYTOSKELETON KINETOCHORE Kinesin motor protein involved in mitotic spindle assembly and chromosome segregation mitotic anaphase B|microtubule depolymerization|spindle pole body separation|mitotic spindle organization in nucleus|mitotic sister chromatid segregation plus-end-directed microtubule motor activity|minus-end-directed microtubule motor activity spindle microtubule|kinesin complex|mitochondrion|condensed nuclear chromosome kinetochore|kinetochore microtubule|astral microtubule
YBR133C YBR133C HSL7 hom Verified 3.41958156179316 0.000313587638790042 yes 66 0.000926541686155788 43 NA FT CELL CYCLE|CHROMATIN ORGANIZATION|CELL DIVISION SITE OF POLARIZED GROWTH Protein arginine N-methyltransferase; exhibits septin and Hsl1p-dependent bud neck localization and periodic Hsl1p-dependent phosphorylation; required along with Hsl1p for bud neck recruitment, phosphorylation, and degradation of Swe1p; relocalizes away from bud neck upon DNA replication stress G2/M transition of mitotic cell cycle|regulation of cell cycle protein-arginine omega-N symmetric methyltransferase activity|protein-arginine omega-N monomethyltransferase activity cellular bud neck
YJL027C_p YJL027C YJL027C hom Uncharacterized 3.34718463422085 0.000408184085096681 yes 67 0.000253123084987321 22 NA Putative protein of unknown function biological_process molecular_function cellular_component
YER173W YER173W RAD24 hom Verified 3.29449235888263 0.000492998126779938 yes 68 0.000682996248784638 19 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME Checkpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints; subunit of a clamp loader that loads Rad17p-Mec3p-Ddc1p onto DNA; homolog of human and S. pombe Rad17 protein reciprocal meiotic recombination|DNA damage checkpoint|nucleotide-excision repair DNA clamp loader activity Rad17 RFC-like complex|nucleus
YGL179C YGL179C TOS3 hom Verified 3.29385768977573 0.000494112587755753 yes 69 0.00012731995356831 19 NA FT CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION Protein kinase, related to and functionally redundant with Elm1p and Sak1p for the phosphorylation and activation of Snf1p; functionally orthologous to LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome protein phosphorylation|glucose metabolic process protein serine/threonine kinase activity|protein kinase activity nucleus|cytoplasm
YNL098C YNL098C RAS2 hom Verified 3.27619545794253 0.000526078585891854 yes 70 0.00225401289593627 51 NA FT PROTEIN LOCALIZATION|SIGNALING|NUCLEOTIDE METABOLISM|RESPONSE TO NUTRIENT LEVELS PLASMA MEMBRANE GTP-binding protein that regulates the nitrogen starvation response, sporulation, and filamentous growth; farnesylation and palmitoylation required for activity and localization to plasma membrane; homolog of mammalian Ras proto-oncogenes pseudohyphal growth|ascospore formation|activation of adenylate cyclase activity|regulation of protein localization|replicative cell aging|positive regulation of transcription by galactose|Ras protein signal transduction GTP binding|GTPase activity plasma membrane
YDR337W YDR337W MRPS28 hom Verified 3.26949937724715 0.000538689872354294 yes 71 0.0017728307553606 67 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the small subunit mitochondrial translation structural constituent of ribosome|RNA binding mitochondrion|mitochondrial small ribosomal subunit
YDR307W_p YDR307W PMT7 hom Uncharacterized 3.24708190798309 0.000582974148378884 yes 72 0.000386221538225933 25 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Putative protein mannosyltransferase similar to Pmt1p; has a potential role in protein O-glycosylation biological_process molecular_function integral to membrane|endoplasmic reticulum
YDL112W YDL112W TRM3 hom Verified 3.23632649341114 0.000605394045362846 yes 73 0.000855049503403832 40 NA FT RNA PROCESSING 2'-O-ribose methyltransferase, catalyzes the ribose methylation of the guanosine nucleotide at position 18 of tRNAs tRNA methylation tRNA (guanine) methyltransferase activity cytoplasm
YBR185C YBR185C MBA1 hom Verified 3.23107921916398 0.000616618774066819 yes 74 0.000394661720551149 19 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Membrane-associated mitochondrial ribosome receptor; forms a complex with Mdm38p that may facilitate recruitment of mRNA-specific translational activators to ribosomes; possible role in protein export from the matrix to inner membrane protein insertion into mitochondrial membrane from inner side|mitochondrial respiratory chain complex III biogenesis|inner mitochondrial membrane organization|positive regulation of mitochondrial translation|mitochondrial respiratory chain complex IV biogenesis ribosome binding mitochondrion|mitochondrial inner membrane
YBR156C YBR156C SLI15 hom Verified 3.22271338180939 0.000634912730563812 yes 75 0.00049076836739736 38 NA FT CELL DIVISION|PROTEIN PHOSPHORYLATION|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME|CYTOSKELETON Subunit of the conserved chromosomal passenger complex (CPC; Ipl1p-Sli15p-Bir1p-Nbl1p), which regulates kinetochore-microtubule attachments, activation of the spindle tension checkpoint, and mitotic spindle disassembly chromosome segregation|protein phosphorylation|regulation of cytokinesis protein kinase activator activity spindle microtubule|spindle midzone|chromosome passenger complex|kinetochore microtubule
YOR307C YOR307C SLY41 hom Verified 3.2189097033182 0.00064339499564383 yes 76 0.000762079388512495 26 NA FT VESICLE-MEDIATED TRANSPORT ENDOPLASMIC RETICULUM Protein involved in ER-to-Golgi transport ER to Golgi vesicle-mediated transport molecular_function integral to membrane|endoplasmic reticulum
YML013W YML013W UBX2 hom Verified 3.20175780470289 0.000682958943008097 yes 77 0.00270197051820192 100 NA FF|FT PROTEOLYSIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION UBIQUITIN LIGASE COMPLEX Bridging factor involved in ER-associated protein degradation (ERAD); bridges the cytosolic Cdc48p-Npl1p-Ufd1p ATPase complex and the membrane associated Ssm4p and Hrd1p ubiquitin ligase complexes; contains a UBX (ubiquitin regulatory X) domain and a ubiquitin-associated (UBA) domain; redistributes from the ER to lipid droplets during the diauxic shift and stationary phase; required for the maintenance of lipid homeostasis proteasomal ubiquitin-dependent protein catabolic process|ER-associated protein catabolic process|lipid particle organization protein binding, bridging mitochondrial outer membrane|Doa10p ubiquitin ligase complex|integral to endoplasmic reticulum membrane|lipid particle|endoplasmic reticulum
YCR036W YCR036W RBK1 hom Verified 3.19235129853034 0.00070559792833225 yes 78 0.00457888977964415 63 NA FT CARBOHYDRATE METABOLISM NUCLEUS Putative ribokinase D-ribose metabolic process ribokinase activity|ATP binding nucleus|cytoplasm
YGR015C_p YGR015C YGR015C hom Uncharacterized 3.18025498284903 0.000735727574509341 yes 79 0.00117569606865306 20 NA FT MITOCHONDRION Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion biological_process molecular_function mitochondrion
YLR137W YLR137W RKM5 hom Verified 3.15423099645796 0.000804608284448994 yes 80 0.000253530257789527 19 NA Protein lysine methyltransferase; monomethylates Lys-46 of the ribosomal large subunit Rpl1a/Rpl1b; member of the seven beta-strand methyltransferase superfamily; orthologs only found among fungal species protein methylation S-adenosylmethionine-dependent methyltransferase activity cellular_component
YGL140C_p YGL140C YGL140C hom Uncharacterized 3.14136479220805 0.000840812169963478 yes 81 9.47456570617416e-05 11 NA Putative protein of unknown function; non-essential gene; contains multiple predicted transmembrane domains biological_process molecular_function integral to membrane
YOR137C YOR137C SIA1 hom Verified 3.13742978938201 0.000852180442728987 yes 82 0.00050922311337447 29 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS Protein of unassigned function involved in activation of the Pma1p plasma membrane H+-ATPase by glucose proton transport molecular_function cellular_component
YHR195W YHR195W NVJ1 hom Verified 3.13296887914035 0.000865238945425822 yes 83 0.00112219455745684 52 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION ENDOMEMBRANE SYSTEM|NUCLEUS Nuclear envelope protein, anchored to the nuclear inner membrane, that interacts with the vacuolar membrane protein Vac8p to promote formation of nucleus-vacuole junctions during piecemeal microautophagy of the nucleus (PMN) microautophagy|cellular protein localization protein binding nuclear envelope
YHR080C YHR080C YHR080C hom Verified 3.1226046261013 0.0008962918934579 yes 84 0.00114506802141778 35 NA FT MITOCHONDRION Protein of unknown function; may interact with ribosomes, based on co-purification experiments; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YHR080C has a paralog, YSP2, that arose from the whole genome duplication biological_process molecular_function mitochondrion|ribosome
YIL034C YIL034C CAP2 hom Verified 3.11919761620806 0.000906721453763121 yes 85 0.000756495011576975 67 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH|CYTOSKELETON Beta subunit of the capping protein heterodimer (Cap1p and Cap2p); capping protein (CP) binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches; protein increases in abundance and relocalizes from bud neck to plasma membrane upon DNA replication stress barbed-end actin filament capping|filamentous growth actin filament binding actin filament|F-actin capping protein complex|mating projection tip|actin cortical patch
YPL227C YPL227C ALG5 hom Verified 3.07879086236992 0.00103921265446402 no 86 0.00154959743273149 69 NA FT CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM UDP-glucose:dolichyl-phosphate glucosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulum protein N-linked glycosylation dolichyl-phosphate beta-glucosyltransferase activity endoplasmic reticulum membrane
YHL007C YHL007C STE20 hom Verified 3.0730339409167 0.00105947193001652 no 87 0.00123743269136989 45 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|SIGNALING|CELL DIVISION|PROTEIN PHOSPHORYLATION NUCLEUS|SITE OF POLARIZED GROWTH Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family; involved in pheromone response, pseudohyphal/invasive growth, vacuole inheritance, down-regulation of sterol uptake; GBB motif binds Ste4p negative regulation of gene expression|osmosensory signaling pathway via Sho1 osmosensor|activation of MAPKKK activity|vacuole inheritance|protein phosphorylation|cellular bud site selection|cellular response to heat|regulation of exit from mitosis|pheromone-dependent signal transduction involved in conjugation with cellular fusion|signal transduction involved in filamentous growth|pseudohyphal growth|sterol import|stress granule assembly|invasive growth in response to glucose limitation|positive regulation of apoptotic process histone serine kinase activity|MAP kinase kinase kinase kinase activity|protein kinase activity incipient cellular bud site|plasma membrane|nucleus|mating projection tip
YDR320C YDR320C SWA2 hom Verified 3.0435863528801 0.00116888168567655 no 88 0.00937214122340541 119 NA FF|FT VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|NUCLEOTIDE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Auxilin-like protein involved in vesicular transport; clathrin-binding protein required for uncoating of clathrin-coated vesicles positive regulation of ATPase activity|endoplasmic reticulum inheritance|clathrin coat disassembly ubiquitin binding|clathrin binding endoplasmic reticulum membrane
YNL284C YNL284C MRPL10 hom Verified 3.04211468876197 0.0011746118353918 no 89 0.00180836301488974 59 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL10 and YmL18) on two-dimensional SDS gels mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YJR034W YJR034W PET191 hom Verified 3.03969062269497 0.00118410641062441 no 90 0.00165263471969248 44 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Protein required for assembly of cytochrome c oxidase; exists as an oligomer; described as both an integral mitochondrial inner membrane protein facing the intermembrane space (IMS) and as a soluble IMS protein; contains a twin Cx9C motif; imported into the IMS via the MIA import machinery mitochondrial respiratory chain complex IV assembly molecular_function mitochondrion|integral to mitochondrial inner membrane
YDL045W-A YDL045W-A MRP10 hom Verified 3.02870050059852 0.00122804019366671 no 91 0.00468076963342807 33 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the small subunit; contains twin cysteine-x9-cysteine motifs mitochondrial translation|mitochondrial respiratory chain complex assembly structural constituent of ribosome mitochondrial small ribosomal subunit
YDL104C YDL104C QRI7 hom Verified 3.02414639641285 0.00124667876566966 no 92 0.00102073291044972 28 NA FT RNA PROCESSING|PROTEOLYSIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Highly conserved mitochondrial protein, essential for t6A modification of mitochondrial tRNAs that decode ANN codons; similar to Kae1p and E. coli YgjD, both of which are also required for tRNA t6A modification mitochondrial tRNA threonylcarbamoyladenosine modification molecular_function mitochondrion
YMR267W YMR267W PPA2 hom Verified 3.00737963031542 0.00131755229444145 no 93 0.00429155661553665 84 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Mitochondrial inorganic pyrophosphatase, required for mitochondrial function and possibly involved in energy generation from inorganic pyrophosphate aerobic respiration inorganic diphosphatase activity mitochondrion
YOL083W YOL083W ATG34 hom Verified 3.00219732107261 0.00134019187201853 no 94 0.000460826725645327 26 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS Receptor protein involved in selective autophagy during starvation; specifically involved in the transport of cargo protein alpha-mannosidase (Ams1p); Atg19p paralog protein complex assembly|protein complex localization protein binding, bridging CVT complex
YDR540C YDR540C IRC4 hom Verified 2.93976204233689 0.00164232198070922 no 95 0.00692136378894711 114 NA FF|FT NUCLEUS Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus mitotic recombination molecular_function nucleus|cytoplasm
YBL055C YBL055C YBL055C hom Verified 2.93490868101036 0.00166822931849421 no 96 0.000673462666254425 37 NA FT RESPONSE TO OXIDATIVE STRESS 3'-->5' exonuclease and endonuclease with a possible role in apoptosis; has similarity to mammalian and C. elegans apoptotic nucleases cellular response to oxidative stress|apoptotic DNA fragmentation 3'-5'-exodeoxyribonuclease activity|endonuclease activity cytoplasm
YDL062W_d YDL062W YDL062W hom Dubious 2.93180435555053 0.00168499486565013 no 97 0.00189705633426242 34 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized ORF YDL063C; YDL062W is not essential Unknown Unknown Unknown
YDR504C YDR504C SPG3 hom Verified 2.92896681305737 0.00170045365626016 no 98 0.000558338854489234 22 NA Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources biological_process molecular_function cellular_component
YOR127W YOR127W RGA1 hom Verified 2.92572438321192 0.00171827624952801 no 99 0.00157730513516148 31 NA FT SIGNALING|CELL DIVISION|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH|CYTOSKELETON GTPase-activating protein for polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth; relocalizes from bud neck to cytoplasm upon DNA replication stress budding cell isotropic bud growth|pheromone-dependent signal transduction involved in conjugation with cellular fusion|pseudohyphal growth|actin filament organization|establishment of cell polarity|small GTPase mediated signal transduction|invasive growth in response to glucose limitation|budding cell apical bud growth Rho GTPase activator activity cellular bud neck split septin rings
YER182W_p YER182W FMP10 hom Uncharacterized 2.92540248642458 0.00172005485880132 no 100 0.00130649931543664 60 NA FT MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process molecular_function mitochondrion
YLR150W YLR150W STM1 hom Verified 2.92154948859265 0.00174147468587987 no 101 0.00289000913371054 53 NA FT SIGNALING|TRANSLATION NUCLEUS RIBOSOME Protein required for optimal translation under nutrient stress; perturbs association of Yef3p with ribosomes; involved in TOR signaling; binds G4 quadruplex and purine motif triplex nucleic acid; helps maintain telomere structure; protein abundance increases in response to DNA replication stress; serves as a ribosome preservation factor both during quiescence and recovery translational elongation|TOR signaling cascade|regulation of translational initiation in response to stress|telomere maintenance|anti-apoptosis triplex DNA binding|DNA binding|telomeric DNA binding cytosolic ribosome|polysome|cytoplasm
YJL093C YJL093C TOK1 hom Verified 2.90175882749047 0.00185537048307285 no 102 0.00182772030242798 43 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE Outward-rectifier potassium channel of the plasma membrane with two pore domains in tandem, each of which forms a functional channel permeable to potassium; carboxy tail functions to prevent inner gate closures; target of K1 toxin cellular potassium ion homeostasis potassium channel activity integral to membrane|plasma membrane
YGR132C YGR132C PHB1 hom Verified 2.89917251363896 0.00187074485399637 no 103 0.000851334671966057 30 NA FT MEMBRANE ORGANIZATION|PROTEOLYSIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation mitochondrion inheritance|protein folding|negative regulation of proteolysis|replicative cell aging|mitochondrion morphogenesis|inner mitochondrial membrane organization molecular_function mitochondrion|mitochondrial inner membrane
YBL058W YBL058W SHP1 hom Verified 2.89819749699779 0.00187657084386006 no 104 0.00190166469063735 19 NA FT PROTEIN LOCALIZATION|CELL CYCLE|MEMBRANE ORGANIZATION|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|PROTEOLYSIS|CYTOSKELETON ORGANIZATION|RESPONSE TO NUTRIENT LEVELS|GEN. OF PRECURSOR METABOLITES AND ENERGY|CHROMOSOME SEGREGATION NUCLEUS UBX (ubiquitin regulatory X) domain-containing protein that regulates Glc7p phosphatase activity and interacts with Cdc48p; interacts with ubiquitylated proteins in vivo and is required for degradation of a ubiquitylated model substrate glycogen metabolic process|proteasomal ubiquitin-dependent protein catabolic process|piecemeal microautophagy of nucleus|ER-associated protein catabolic process|ascospore formation|sister chromatid biorientation|autophagic vacuole assembly protein phosphatase type 1 regulator activity nucleus|cytoplasm
YIR017C YIR017C MET28 hom Verified 2.89586399742279 0.00189058116037575 no 105 0.00482672850545848 42 NA FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS Basic leucine zipper (bZIP) transcriptional activator in the Cbf1p-Met4p-Met28p complex, participates in the regulation of sulfur metabolism regulation of transcription from RNA polymerase II promoter|regulation of sulfur amino acid metabolic process|Unknown RNA polymerase II activating transcription factor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus
YBL091C-A YBL091C-A SCS22 hom Verified 2.88073614178903 0.00198373812839324 no 106 0.00179925329132793 60 NA FT LIPID METABOLISM Protein involved in regulation of phospholipid metabolism; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; similar to D. melanogaster inturned protein; SCS22 has a paralog, SCS2, that arose from the whole genome duplication phospholipid biosynthetic process|chromatin silencing at telomere molecular_function cellular_component
YGL229C YGL229C SAP4 hom Verified 2.87603435698086 0.00201352938110602 no 107 0.0020158806659135 37 NA FT CELL CYCLE MITOCHONDRION Protein required for function of the Sit4p protein phosphatase, member of a family of similar proteins that form complexes with Sit4p, including Sap155p, Sap185p, and Sap190p G1/S transition of mitotic cell cycle protein serine/threonine phosphatase activity mitochondrion|cytoplasm
YHL043W YHL043W ECM34 hom Verified 2.8181509629952 0.00241505470995746 no 108 0.00152396592710658 32 NA FT CELL WALL ORG/BIOGENESIS Putative protein of unknown function; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins fungal-type cell wall organization molecular_function cellular_component
YDR358W YDR358W GGA1 hom Verified 2.81587830697072 0.00243220442767491 no 109 0.00102660238330518 23 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEOLYSIS|VACUOLAR TRANSPORT GOLGI APPARATUS Golgi-localized protein with homology to gamma-adaptin, interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner in order to facilitate traffic through the late Golgi Golgi to vacuole transport|protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|Golgi to endosome transport ubiquitin binding trans-Golgi network
YKR078W YKR078W YKR078W hom Verified 2.81509725026136 0.00243812376015342 no 110 0.0027977989460712 71 NA Cytoplasmic protein of unknown function, has similarity to Vps5p; potential Cdc28p substrate; contains a Phox homology (PX) domain and specifically binds phosphatidylinositol 3-phosphate (PtdIns-3-P) biological_process phosphatidylinositol-3-phosphate binding cytoplasm
YKL041W YKL041W VPS24 hom Verified 2.80897090276957 0.00248500691574718 no 111 0.00431696746568732 100 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|PROTEOLYSIS|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); forms an ESCRT-III subcomplex with Did4p; involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway intralumenal vesicle formation|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|late endosome to vacuole transport molecular_function ESCRT III complex|cytoplasm
YMR223W YMR223W UBP8 hom Verified 2.80453303452615 0.00251947618631185 no 112 0.00140028615632822 41 NA FT CHROMATIN ORGANIZATION|PROTEOLYSIS NUCLEUS HISTONE ACETYLTRANSFERASE Ubiquitin-specific protease that is a component of the SAGA (Spt-Ada-Gcn5-Acetyltransferase) acetylation complex; required for SAGA-mediated deubiquitination of histone H2B histone H3-K4 methylation|histone deubiquitination|histone H3-K79 methylation ubiquitin-specific protease activity|protein complex scaffold DUBm complex|SLIK (SAGA-like) complex|SAGA complex
YDR008C_d YDR008C YDR008C hom Dubious 2.79459852322124 0.00259821020138015 no 113 0.08008655990136 546 NA FF Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YHR177W_p YHR177W YHR177W hom Uncharacterized 2.75830260225104 0.00290511924926255 no 114 0.00301296497444078 55 NA Putative protein of unknown function; overexpression causes a cell cycle delay or arrest biological_process molecular_function cellular_component
YLR073C YLR073C RFU1 hom Verified 2.75450717944992 0.00293903001574805 no 115 0.0051033940672897 62 NA Protein that inhibits Doa4p deubiquitinating activity; contributes to ubiquitin homeostasis by regulating the conversion of free ubiquitin chains to ubiquitin monomers by Doa4p; GFP-fusion protein localizes to endosomes regulation of ubiquitin homeostasis enzyme inhibitor activity endosome
YPR145W YPR145W ASN1 hom Verified 2.73587137047795 0.00311076700743852 no 116 0.00458795713291853 76 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Asparagine synthetase; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway; ASN1 has a paralog, ASN2, that arose from the whole genome duplication asparagine biosynthetic process asparagine synthase (glutamine-hydrolyzing) activity cytoplasm
YPL111W YPL111W CAR1 hom Verified 2.73331862048315 0.00313498231113544 no 117 0.00408275329949258 60 NA FT KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS|SITE OF POLARIZED GROWTH Arginase, responsible for arginine degradation, expression responds to both induction by arginine and nitrogen catabolite repression; disruption enhances freeze tolerance regulation of ornithine metabolic process|arginine catabolic process to ornithine manganese ion binding|arginase activity|ornithine carbamoyltransferase inhibitor activity|zinc ion binding cytosol|nucleus|mating projection tip|cytoplasm
YML018C YML018C YML018C hom Verified 2.73044263743657 0.00316246696019593 no 118 0.00356979083414521 68 NA Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the membrane of the vacuole; physical interaction with Atg27p suggests a possible role in autophagy; YML018C is not an essential gene; relative distribution to the vacuolar membrane decreases upon DNA replication stress; YML018C has a paralog, THI74, that arose from the whole genome duplication biological_process molecular_function fungal-type vacuole membrane|integral to membrane
YMR056C YMR056C AAC1 hom Verified 2.72516607163468 0.00321345756464583 no 119 0.00228743003964234 66 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION Mitochondrial inner membrane ADP/ATP translocator; exchanges cytosolic ADP for mitochondrially synthesized ATP; phosphorylated; Aac1p is a minor isoform while Pet9p is the major ADP/ATP translocator; relocalizes from mitochondrion to cytoplasm upon DNA replication stress heme biosynthetic process|mitochondrial transport|heme transport|aerobic respiration ATP:ADP antiporter activity mitochondrion|integral to membrane|mitochondrial inner membrane
YGR137W_d YGR137W YGR137W hom Dubious 2.71489325593035 0.00331485677959406 no 120 0.0024324170339565 36 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YCR099C_p YCR099C YCR099C hom Uncharacterized 2.70949811625393 0.00336925438980369 no 121 0.00322764542421893 79 NA Putative protein of unknown function biological_process molecular_function integral to membrane
YNR006W YNR006W VPS27 hom Verified 2.70871437450582 0.00337722302207001 no 122 0.012303385540206 128 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT Endosomal protein that forms a complex with Hse1p; required for recycling Golgi proteins, forming lumenal membranes and sorting ubiquitinated proteins destined for degradation; has Ubiquitin Interaction Motifs which bind ubiquitin (Ubi4p) protein retention in Golgi apparatus|late endosome to vacuole transport|protein targeting to vacuole ubiquitin binding|phosphatidylinositol-3-phosphate binding endosome|ESCRT-0 complex
YNL322C YNL322C KRE1 hom Verified 2.70213049978836 0.00344483575433634 no 123 0.00404903030801653 97 NA FT CELL WALL ORG/BIOGENESIS PLASMA MEMBRANE Cell wall glycoprotein involved in beta-glucan assembly; serves as a K1 killer toxin membrane receptor fungal-type cell wall organization structural constituent of cell wall fungal-type cell wall|integral to membrane
YCL061C YCL061C MRC1 hom Verified 2.68521372289 0.00362417199128695 no 124 0.00704346236220319 107 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION|GENE SILENCING NUCLEUS|CHROMOSOME S-phase checkpoint protein required for DNA replication; interacts with and stabilizes Pol2p at stalled replication forks during stress, where it forms a pausing complex with Tof1p and is phosphorylated by Mec1p; protects uncapped telomeres maintenance of DNA repeat elements|intra-S DNA damage checkpoint|DNA repair|DNA replication checkpoint|telomere maintenance|replication fork protection|DNA replication|mitotic sister chromatid cohesion|chromatin silencing at silent mating-type cassette|chromatin silencing at telomere molecular_function nuclear chromosome|replication fork protection complex|nucleus|nuclear replication fork
YMR188C YMR188C MRPS17 hom Verified 2.68385256607113 0.00363895965149582 no 125 0.00401134028670011 81 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the small subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial small ribosomal subunit
YBR021W YBR021W FUR4 hom Verified 2.67120464186311 0.00377897768989925 no 126 0.0165516225104839 185 NA FF|FT PLASMA MEMBRANE Plasma membrane localized uracil permease; expression is tightly regulated by uracil levels and environmental cues; conformational alterations induced by unfolding or substrate binding result in Rsp5p-mediated ubiquitination and degradation uracil transport|transmembrane transport uracil:cation symporter activity integral to membrane|membrane raft|plasma membrane
YNR023W YNR023W SNF12 hom Verified 2.65952940124967 0.00391249500193923 no 127 0.0252154366406411 148 NA FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS NUCLEUS RSC COMPLEX 73 kDa subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; homolog of Rsc6p subunit of the RSC chromatin remodeling complex; relocates to the cytosol under hypoxic conditions; deletion mutants are temperature-sensitive positive regulation of transcription from RNA polymerase II promoter in response to amino acid starvation|positive regulation of transcription from RNA polymerase II promoter molecular_function SWI/SNF complex
YNL120C_d YNL120C YNL120C hom Dubious 2.63322468787284 0.00422891872819364 no 128 0.00267295774383402 80 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; deletion enhances replication of Brome mosaic virus in S. cerevisiae, but likely due to effects on the overlapping gene Unknown Unknown Unknown
YBL107C YBL107C MIC23 hom Verified 2.62912206054882 0.00428028140704526 no 129 0.00670103159979899 61 NA Mitochondrial intermembrane space protein of unknown function; imported via the MIA import machinery; contains an unusual twin cysteine motif (CX13C CX14C) biological_process molecular_function cytoplasm
YDR380W YDR380W ARO10 hom Verified 2.60983402560314 0.00452930806445253 no 130 0.00224373132655346 34 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Phenylpyruvate decarboxylase, catalyzes decarboxylation of phenylpyruvate to phenylacetaldehyde, which is the first specific step in the Ehrlich pathway L-phenylalanine catabolic process|methionine catabolic process to 3-methylthiopropanol|tryptophan catabolic process|branched-chain amino acid catabolic process to alcohol via Ehrlich pathway|aromatic amino acid family catabolic process to alcohol via Ehrlich pathway|leucine catabolic process pyruvate decarboxylase activity|carboxy-lyase activity|phenylpyruvate decarboxylase activity cytoplasm
YNL202W YNL202W SPS19 hom Verified 2.59292916402784 0.00475811842989677 no 131 0.00784424619037566 100 NA FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS Peroxisomal 2,4-dienoyl-CoA reductase, auxiliary enzyme of fatty acid beta-oxidation; homodimeric enzyme required for growth and sporulation on petroselineate medium; expression induced during late sporulation and in the presence of oleate fatty acid catabolic process|ascospore formation 2,4-dienoyl-CoA reductase (NADPH) activity peroxisomal matrix
YIL043C YIL043C CBR1 hom Verified 2.59084947200602 0.00478696792448255 no 132 0.00647398567831274 97 NA FT OXIDATION-REDUCTION PROCESS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION Microsomal cytochrome b reductase, not essential for viability; also detected in mitochondria; mutation in conserved NADH binding domain of the human ortholog results in type I methemoglobinemia biological_process cytochrome-b5 reductase activity mitochondrial outer membrane|mitochondrion
YER048C YER048C CAJ1 hom Verified 2.58950161170816 0.00480574864575834 no 133 0.00353154020646752 61 NA FT NUCLEUS Nuclear type II J heat shock protein of the E. coli dnaJ family, contains a leucine zipper-like motif, binds to non-native substrates for presentation to Ssa3p, may function during protein translocation, assembly and disassembly protein folding chaperone binding nucleus
YPL141C YPL141C FRK1 hom Verified 2.57664573903852 0.00498820695865304 no 134 0.00451677299960613 93 NA FT PROTEIN PHOSPHORYLATION Protein kinase of unknown cellular role; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; interacts with rRNA transcription and ribosome biogenesis factors and the long chain fatty acyl-CoA synthetase Faa3p; FRK1 has a paralog, KIN4, that arose from the whole genome duplication protein phosphorylation protein kinase activity cytoplasm
YGL205W YGL205W POX1 hom Verified 2.57339045386229 0.00503537610581266 no 135 0.00160123121402579 41 NA FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS Fatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix fatty acid beta-oxidation using acyl-CoA oxidase|fatty acid beta-oxidation acyl-CoA oxidase activity peroxisomal matrix
YJL147C_p YJL147C YJL147C hom Uncharacterized 2.56797640679235 0.00511470590462832 no 136 0.00294207128164987 51 NA FT MITOCHONDRION Mitochondrial protein of unknown function; homozygous diploid deletion strain has a sporulation defect characterized by elevated dityrosine in the soluble fraction; expression induced by calcium shortage; YJL147W is a non-essential gene biological_process molecular_function mitochondrion
YIR018C-A_p YIR018C-A YIR018C-A hom Uncharacterized 2.5613770165166 0.00521290733800888 no 137 0.00398767920012587 67 NA Putative protein of unknown function; identified by expression profiling and mass spectrometry biological_process molecular_function cellular_component
YHR184W YHR184W SSP1 hom Verified 2.55863121466591 0.00525425769686657 no 138 0.0049476094614004 78 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL WALL ORG/BIOGENESIS|CELL DIVISION Protein involved in the control of meiotic nuclear division and coordination of meiosis with spore formation; transcription is induced midway through meiosis ascospore wall assembly|protein complex assembly molecular_function prospore membrane
YDR264C YDR264C AKR1 hom Verified 2.54307168117098 0.0054941342135409 no 139 0.0239854622828258 181 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Palmitoyl transferase involved in protein palmitoylation; acts as a negative regulator of pheromone response pathway; required for endocytosis of pheromone receptors; involved in cell shape control; contains ankyrin repeats; AKR1 has a paralog, AKR2, that arose from the whole genome duplication protein targeting to membrane|regulation of endocytosis|regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion|protein palmitoylation palmitoyltransferase activity integral to membrane|Golgi apparatus|membrane
YHR007C-A_p YHR007C-A YHR007C-A hom Uncharacterized 2.54087919975429 0.00552870580328494 no 140 0.002142609143229 59 NA Putative protein of unknown function; identified by expression profiling and mass spectrometry biological_process molecular_function cellular_component
YKR082W YKR082W NUP133 hom Verified 2.53936619153786 0.0055526758614905 no 141 0.00664487267969216 80 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RNA LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS NUCLEAR PORE Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport and NPC biogenesis and is involved in establishment of a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p; also plays roles in several processes that may require localization of genes or chromosomes at the nuclear periphery, including double-strand break repair, transcription and chromatin silencing; homologous to human NUP133 poly(A)+ mRNA export from nucleus|double-strand break repair|maintenance of chromatin silencing at telomere|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|tRNA export from nucleus|telomere tethering at nuclear periphery|nuclear pore distribution|mRNA export from nucleus in response to heat stress|positive regulation of transcription, DNA-dependent|negative regulation of transcription from RNA polymerase II promoter|protein import into nucleus|positive regulation of transcription from RNA polymerase II promoter|chromatin silencing at silent mating-type cassette structural constituent of nuclear pore integral to membrane|nuclear pore|nuclear pore outer ring
YAR031W YAR031W PRM9 hom Verified 2.53679616040772 0.00559360360781352 no 142 0.00689640192130529 56 NA FT VESICLE-MEDIATED TRANSPORT ENDOPLASMIC RETICULUM|PLASMA MEMBRANE Pheromone-regulated protein with 3 predicted transmembrane segments and an FF sequence, a motif involved in COPII binding; member of DUP240 gene family vesicle organization molecular_function integral to membrane|endoplasmic reticulum|plasma membrane
YDL172C_d YDL172C YDL172C hom Dubious 2.52191084787794 0.00583596427881456 no 143 0.00998289469815668 104 NA Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YPL254W YPL254W HFI1 hom Verified 2.51694456481679 0.00591887264223935 no 144 0.00908713784610253 94 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION NUCLEUS HISTONE ACETYLTRANSFERASE Adaptor protein required for structural integrity of the SAGA complex, a histone acetyltransferase-coactivator complex that is involved in global regulation of gene expression through acetylation and transcription functions histone acetylation|chromatin modification|transcription from RNA polymerase II promoter transcription coactivator activity|transcription cofactor activity SLIK (SAGA-like) complex|Ada2/Gcn5/Ada3 transcription activator complex|SAGA complex
YPL069C YPL069C BTS1 hom Verified 2.51331646175769 0.00598009967818767 no 145 0.074860085047539 417 NA FF|FT PROTEIN LOCALIZATION|LIPID METABOLISM MITOCHONDRION Geranylgeranyl diphosphate synthase, increases the intracellular pool of geranylgeranyl diphosphate, suppressor of bet2 mutation that causes defective geranylgeranylation of small GTP-binding proteins that mediate vesicular traffic terpenoid biosynthetic process farnesyltranstransferase activity mitochondrion
YBL091C YBL091C MAP2 hom Verified 2.51104651889524 0.00601869166372345 no 146 0.00549452276859595 65 NA FT PROTEOLYSIS Methionine aminopeptidase, catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map1p protein initiator methionine removal involved in protein maturation metalloaminopeptidase activity cytoplasm
YNL246W YNL246W VPS75 hom Verified 2.51071588701621 0.00602433121720135 no 147 0.0104706853157178 129 NA FT PROTEIN LOCALIZATION|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME NAP family histone chaperone; binds to histones and Rtt109p, stimulating histone acetyltransferase activity; possesses nucleosome assembly activity in vitro; proposed role in vacuolar protein sorting and in double-strand break repair; protein abundance increases in response to DNA replication stress double-strand break repair via nonhomologous end joining|nucleosome assembly|positive regulation of histone acetylation histone binding|acetyltransferase activator activity chromatin|nucleus
YBR173C YBR173C UMP1 hom Verified 2.5004169918163 0.00620235997662861 no 148 0.00389477176750216 68 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RESPONSE TO DNA DAMAGE|PROTEOLYSIS NUCLEUS Short-lived chaperone required for correct maturation of the 20S proteasome; may inhibit premature dimerization of proteasome half-mers; degraded by proteasome upon completion of its assembly proteasome assembly|response to DNA damage stimulus|ubiquitin-dependent protein catabolic process molecular_function nucleus|cytoplasm
YMR283C YMR283C RIT1 hom Verified 2.48730975351856 0.00643566377632114 no 149 0.00378818067656432 66 NA FT RNA PROCESSING 2'-O-ribosyl phosphate transferase, modifies the initiator methionine tRNA at position 64 to distinguish it from elongator methionine tRNA charged-tRNA amino acid modification transferase activity, transferring pentosyl groups cytoplasm
YDR316W YDR316W OMS1 hom Verified 2.48278783140966 0.00651793525985665 no 150 0.0123513330486174 105 NA FT MITOCHONDRION Protein integral to the mitochondrial membrane; has a conserved methyltransferase motif; multicopy suppressor of respiratory defects caused by OXA1 mutations biological_process S-adenosylmethionine-dependent methyltransferase activity mitochondrial envelope|mitochondrion
YHR067W YHR067W HTD2 hom Verified 2.48118028030652 0.00654740626317897 no 151 0.0155522774002034 146 NA FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS MITOCHONDRION Mitochondrial 3-hydroxyacyl-thioester dehydratase involved in fatty acid biosynthesis, required for respiratory growth and for normal mitochondrial morphology fatty acid biosynthetic process 3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity mitochondrion
YDR463W YDR463W STP1 hom Verified 2.47754559891919 0.00661447518279793 no 152 0.0304249365475053 147 NA FT TRANSCRIPTION FROM RNA POL II|RNA PROCESSING NUCLEUS|PLASMA MEMBRANE Transcription factor; undergoes proteolytic processing by SPS (Ssy1p-Ptr3p-Ssy5p)-sensor component Ssy5p in response to extracellular amino acids; activates transcription of amino acid permease genes and may have a role in tRNA processing; STP1 has a paralog, STP2, that arose from the whole genome duplication positive regulation of transcription, DNA-dependent|tRNA splicing, via endonucleolytic cleavage and ligation|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription plasma membrane|nucleus|cytoplasm
YHR141C YHR141C RPL42B hom Verified 2.4543113475567 0.00705773537819899 no 153 0.0124497873399233 80 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L42B; required for propagation of the killer toxin-encoding M1 double-stranded RNA satellite of the L-A double-stranded RNA virus; homologous to mammalian ribosomal protein L36A, no bacterial homolog; RPL42B has a paralog, RPL42A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YHR155W YHR155W YSP1 hom Verified 2.45423296516509 0.00705927407352223 no 154 0.0106953034105484 142 NA FF|FT MITOCHONDRION Mitochondrial protein; potential role in promoting mitochondrial fragmentation during programmed cell death in response to high levels of alpha-factor mating pheromone or the drug amiodarone; YSP1 has a paralog, SIP3, that arose from the whole genome duplication biological_process molecular_function mitochondrion
YDR477W YDR477W SNF1 hom Verified 2.43971858354993 0.00734935365351851 no 155 0.00625156267988896 4 NA FT KETONE METABOLISM|SIGNALING|TRANSLATION|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION AMP-activated serine/threonine protein kinase; found in a complex containing Snf4p and members of the Sip1p/Sip2p/Gal83p family; required for transcription of glucose-repressed genes, thermotolerance, sporulation, and peroxisome biogenesis; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p; regulates filamentous growth in response to starvation negative regulation of translation|protein phosphorylation|replicative cell aging|signal transduction|biofilm formation|positive regulation of gluconeogenesis|pseudohyphal growth|cell adhesion|regulation of carbohydrate metabolic process|invasive growth in response to glucose limitation|cellular response to nitrogen starvation AMP-activated protein kinase activity|protein kinase activity mitochondrion|AMP-activated protein kinase complex|nucleus|nuclear envelope lumen|fungal-type vacuole|cytoplasm
YKR070W_p YKR070W YKR070W hom Uncharacterized 2.43690664058104 0.00740675167710282 no 156 0.00779716449957454 79 NA FT MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process molecular_function mitochondrion
YLR361C-A_p YLR361C-A YLR361C-A hom Uncharacterized 2.43446888625121 0.00745683097893265 no 157 0.00334527386128752 71 NA Putative protein of unknown function biological_process molecular_function cellular_component
YNL066W YNL066W SUN4 hom Verified 2.43149500746203 0.00751832777469765 no 158 0.00729918768864951 71 NA FT CELL CYCLE|CELL WALL ORG/BIOGENESIS|CELL DIVISION|MITOCHONDRION ORGANIZATION MITOCHONDRION Cell wall protein related to glucanases, possibly involved in cell wall septation; member of the SUN family mitochondrion organization glucosidase activity fungal-type cell wall|mitochondrial matrix
YLR081W YLR081W GAL2 hom Verified 2.43021837435095 0.00754486401039318 no 159 0.00551599579271662 82 NA FT CARBOHYDRATE METABOLISM PLASMA MEMBRANE Galactose permease, required for utilization of galactose; also able to transport glucose galactose transport|galactose metabolic process galactose transmembrane transporter activity|glucose transmembrane transporter activity integral to membrane|plasma membrane
YJL189W YJL189W RPL39 hom Verified 2.42742703072303 0.00760317272396385 no 160 0.00978694162553096 77 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L39; required for ribosome biogenesis; loss of both Rpl31p and Rpl39p confers lethality; also exhibits genetic interactions with SIS1 and PAB1; homologous to mammalian ribosomal protein L39, no bacterial homolog cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YIL168W YIL168W YIL168W hom pseudogene 2.42702329731654 0.0076116391230157 no 161 0.00740077795950574 73 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Open reading frame, unlikely to produce a functional protein in S288C; in closely related species and other S. cerevisiae strain backgrounds YIL168W and adjacent ORF, YIL167W, constitute a single ORF encoding L-serine dehydratase serine family amino acid metabolic process L-serine ammonia-lyase activity cellular_component
YMR317W_p YMR317W YMR317W hom Uncharacterized 2.41664925954364 0.00783205131642284 no 162 0.00598808608841064 89 NA Putative protein of unknown function with some similarity to sialidase from Trypanosoma; YMR317W is not an essential gene biological_process molecular_function cellular_component
YBR017C YBR017C KAP104 hom Verified 2.40934781078163 0.00799052987098788 no 163 0.00636551008619066 77 NA FT PROTEIN LOCALIZATION|CELL CYCLE SITE OF POLARIZED GROWTH Transportin or cytosolic karyopherin beta 2; functions in the rg-nuclear localization signal-mediated nuclear import/reimport of mRNA-binding proteins Nab2p and Hrp1p; regulates asymmetric protein synthesis in daughter cells during mitosis protein import into nucleus|cell cycle|mRNA-binding (hnRNP) protein import into nucleus|transcription factor import into nucleus nuclear localization sequence binding cytosol|integral to membrane|cellular bud neck|cellular bud tip
YDR336W_p YDR336W YDR336W hom Uncharacterized 2.40576077775154 0.0080694144598653 no 164 0.0103655524820694 93 NA Putative protein of unknown function; sumoylated under stress conditions in a genome wide study; YDR336W is not an essential gene biological_process molecular_function cellular_component
YDR144C YDR144C MKC7 hom Verified 2.40493232869257 0.00808773038545541 no 165 0.00521694585243924 85 NA FT CELL WALL ORG/BIOGENESIS|PROTEOLYSIS PLASMA MEMBRANE GPI-anchored aspartyl protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; shares functions with Yap3p and Kex2p proteolysis|fungal-type cell wall organization aspartic-type endopeptidase activity fungal-type cell wall
YLR013W YLR013W GAT3 hom Verified 2.4001142270011 0.0081949782151725 no 166 0.00663370207171732 77 NA FT NUCLEUS Protein containing GATA family zinc finger motifs transcription, DNA-dependent sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity nucleus
YDR435C YDR435C PPM1 hom Verified 2.39332926568774 0.0083481250051042 no 167 0.0195017343783496 192 NA FF|FT PROTEIN COMPLEX ORG/BIOGENESIS Carboxyl methyltransferase, methylates the C terminus of the protein phosphatase 2A catalytic subunit (Pph21p or Pph22p), which is important for complex formation with regulatory subunits cellular protein complex assembly|C-terminal protein methylation protein C-terminal leucine carboxyl O-methyltransferase activity cellular_component
YLR142W YLR142W PUT1 hom Verified 2.37749874555052 0.00871525113276496 no 168 0.00511928420266231 56 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS MITOCHONDRION Proline oxidase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; PUT1 transcription is induced by Put3p in the presence of proline and the absence of a preferred nitrogen source glutamate biosynthetic process|proline catabolic process to glutamate proline dehydrogenase activity mitochondrion
YBR057C YBR057C MUM2 hom Verified 2.35735234807218 0.00920288665341476 no 169 0.0101499382039855 69 NA FT CELL CYCLE Cytoplasmic protein essential for meiotic DNA replication and sporulation; interacts with Orc2p, which is a component of the origin recognition complex premeiotic DNA replication molecular_function cytoplasm
YLR255C_d YLR255C YLR255C hom Dubious 2.35570120470967 0.00924389091629515 no 170 0.0102724743323221 119 NA Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YLR179C YLR179C YLR179C hom Verified 2.35081015491563 0.00936629430851003 no 171 0.00309186165749662 42 NA FT NUCLEUS Protein of unknown function with similarity to Tfs1p; transcription is activated by paralogous proteins Yrm1p and Yrr1p along with proteins involved in multidrug resistance; GFP-tagged protein localizes to the cytoplasm and nucleus biological_process molecular_function nucleus|cytoplasm
YNR033W YNR033W ABZ1 hom Verified 2.34917834265244 0.00940744628585126 no 172 0.00429447229369258 56 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM Para-aminobenzoate (PABA) synthase; has similarity to Escherichia coli PABA synthase components PabA and PabB; required for the synthesis of para-aminobenzoic acid, an important intermediate for folate and ubiquinone Q biosynthesis; protein abundance increases in response to DNA replication stress para-aminobenzoic acid biosynthetic process 4-amino-4-deoxychorismate synthase activity cytoplasm
YNL157W YNL157W IGO1 hom Verified 2.33314544202656 0.00982025657378312 no 173 0.00217563297052475 36 NA FT NUCLEUS Protein required for initiation of G0 program; prevents degradation of nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway; phosphorylated by Rim15p; GFP protein localizes to the cytoplasm and nucleus; similar to Igo2p mRNA stabilization molecular_function nucleus|cytoplasmic mRNA processing body|cytoplasm
YNL101W YNL101W AVT4 hom Verified 2.3290367689344 0.00992855895286676 no 174 0.00776909384572167 89 NA FT VACUOLAR TRANSPORT Vacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters amino acid export from vacuole transporter activity|L-glutamine transmembrane transporter activity|L-isoleucine transmembrane transporter activity|L-tyrosine transmembrane transporter activity fungal-type vacuole membrane|integral to membrane|fungal-type vacuole
YDL082W YDL082W RPL13A hom Verified 2.32027701061327 0.0101629484652744 no 175 0.00650098477694673 72 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L13A; not essential for viability; homologous to mammalian ribosomal protein L13, no bacterial homolog; RPL13A has a paralog, RPL13B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YNL095C_p YNL095C YNL095C hom Uncharacterized 2.32006661994853 0.0101686368649669 no 176 0.00911301138475682 102 NA Putative protein of unknown function; predicted to contain a transmembrane domain; not an essential gene; YNL095C has a paralog, ECM3, that arose from the whole genome duplication biological_process molecular_function integral to membrane
YLL063C YLL063C AYT1 hom Verified 2.31402522713081 0.010333169192024 no 177 0.00548040660979787 62 NA Acetyltransferase; catalyzes trichothecene 3-O-acetylation, suggesting a possible role in trichothecene biosynthesis secondary metabolic process trichothecene 3-O-acetyltransferase activity cellular_component
YDR456W YDR456W NHX1 hom Verified 2.31046163910039 0.0104313049798462 no 178 0.0111934771665705 184 NA FF|FT ION HOMEOSTASIS|ION HOMEOSTASIS GOLGI APPARATUS Na+/H+ and K+/H+ exchanger, required for intracellular sequestration of Na+ and K+; located in the vacuole and late endosome compartments; required for osmotolerance to acute hypertonic shock and for vacuolar fusion sodium ion transmembrane transport|potassium ion transmembrane transport|cellular monovalent inorganic cation homeostasis|vacuolar acidification sodium:hydrogen antiporter activity|potassium:hydrogen antiporter activity trans-Golgi network|late endosome|fungal-type vacuole membrane|integral to membrane|early endosome
YML005W YML005W TRM12 hom Verified 2.31040358644149 0.010432910363154 no 179 0.0129249227815084 81 NA FT RNA PROCESSING S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; required for wybutosine formation in phenylalanine-accepting tRNA wybutosine biosynthetic process|tRNA methylation S-adenosylmethionine-dependent methyltransferase activity|transferase activity, transferring alkyl or aryl (other than methyl) groups cytoplasm
YGL161C YGL161C YIP5 hom Verified 2.30953062016039 0.0104570772776036 no 180 0.0122835803315544 132 NA FT GOLGI APPARATUS Protein that interacts with Rab GTPases, localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport biological_process Rab GTPase binding integral to membrane|Golgi apparatus
YGR239C YGR239C PEX21 hom Verified 2.29342960249042 0.0109116419903592 no 181 0.0133870670494652 87 NA FT PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION Peroxin required for peroxisomal matrix protein targeting; acts on proteins containing the PTS2 targeting sequence; interacts with Pex7p; partially redundant with Pex18p; relative distribution to cytoplasmic foci increases upon DNA replication stress protein import into peroxisome matrix|positive regulation of protein binding protein binding cytosol|peroxisome
YGR276C YGR276C RNH70 hom Verified 2.29048380149228 0.010996643268011 no 182 0.0102259849990396 95 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS 3'-5' exoribonuclease; required for maturation of 3' ends of 5S rRNA and tRNA-Arg3 from dicistronic transcripts U5 snRNA 3'-end processing|generation of mature 3'-end of 5S rRNA generated by RNA polymerase III|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|tRNA 3'-trailer cleavage, exonucleolytic 3'-5'-exoribonuclease activity|3'-5' exonuclease activity nucleus
YLR285W YLR285W NNT1 hom Verified 2.28517253036804 0.0111513566186253 no 183 0.0067542586614235 74 NA FT NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|GENE SILENCING S-adenosylmethionine-dependent methyltransferase; has a role in rDNA silencing and in lifespan determination chromatin silencing at rDNA|nicotinamide metabolic process S-adenosylmethionine-dependent methyltransferase activity|nicotinamide N-methyltransferase activity cytoplasm
YDL226C YDL226C GCS1 hom Verified 2.27995987556752 0.0113050341663685 no 184 0.0283591112144237 333 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL CYCLE|SIGNALING|NUCLEOTIDE METABOLISM|CYTOSKELETON ORGANIZATION MITOCHONDRION|GOLGI APPARATUS|CYTOSKELETON ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Glo3p retrograde vesicle-mediated transport, Golgi to ER|Golgi to plasma membrane protein transport|actin filament reorganization involved in cell cycle|ER to Golgi vesicle-mediated transport actin binding|ARF GTPase activator activity|GTPase activator activity endosome|trans-Golgi network|endoplasmic reticulum-Golgi intermediate compartment|cytoskeleton
YNR050C YNR050C LYS9 hom Verified 2.27565361966801 0.0114333746830256 no 185 0.0133252307209527 124 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS Saccharopine dehydrogenase (NADP+, L-glutamate-forming); catalyzes the formation of saccharopine from alpha-aminoadipate 6-semialdehyde, the seventh step in lysine biosynthesis pathway; exhibits genetic and physical interactions with TRM112 lysine biosynthetic process via aminoadipic acid saccharopine dehydrogenase (NADP+, L-glutamate-forming) activity cytoplasm
YDR031W YDR031W MIC14 hom Verified 2.26961980749893 0.0116153303845467 no 186 0.00719591592190404 53 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY NUCLEUS|MITOCHONDRION Mitochondrial intermembrane space protein of unknown function; required for normal oxygen consumption; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress aerobic respiration molecular_function nucleus|mitochondrial intermembrane space|cytoplasm
YKL054C YKL054C DEF1 hom Verified 2.26934868299905 0.0116235651117313 no 187 0.00959494730754329 127 NA FT RESPONSE TO DNA DAMAGE|PROTEOLYSIS NUCLEUS|CHROMOSOME RNAPII degradation factor, forms a complex with Rad26p in chromatin, enables ubiquitination and proteolysis of RNAPII present in an elongation complex; mutant is deficient in Zip1p loading onto chromosomes during meiosis transcription-coupled nucleotide-excision repair|telomere maintenance|response to DNA damage stimulus|ubiquitin-dependent protein catabolic process molecular_function nucleus
YOR354C YOR354C MSC6 hom Verified 2.26769316137211 0.0116739574816784 no 188 0.014956916361085 84 NA FT CELL CYCLE MITOCHONDRION Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies reciprocal meiotic recombination molecular_function mitochondrion
YDR529C YDR529C QCR7 hom Verified 2.26351411132526 0.0118020078634338 no 189 0.0209463562221425 170 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Subunit 7 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the mitochondrial matrix; N-terminus appears to play a role in complex assembly mitochondrial electron transport, ubiquinol to cytochrome c|aerobic respiration|mitochondrial respiratory chain complex III assembly ubiquinol-cytochrome-c reductase activity mitochondrion|integral to membrane|mitochondrial respiratory chain complex III
YNL300W_p YNL300W TOS6 hom Uncharacterized 2.25588214805198 0.0120390064114585 no 190 0.0190927423810243 147 NA Glycosylphosphatidylinositol-dependent cell wall protein, expression is periodic and decreases in respone to ergosterol perturbation or upon entry into stationary phase; depletion increases resistance to lactic acid biological_process molecular_function fungal-type cell wall
YMR313C YMR313C TGL3 hom Verified 2.25478805267973 0.0120733177757549 no 191 0.0100994384372399 97 NA FT LIPID METABOLISM|CELL DIVISION Bifunctional enzyme with triacylglycerol lipase and lysophosphatidylethanolamine acyltransferase activity; responsible for all the triacylglycerol lipase activity of the lipid particle; required with Tgl4p for timely bud formation triglyceride catabolic process|cell budding|cellular lipid metabolic process triglyceride lipase activity|lysophosphatidylethanolamine acyltransferase activity lipid particle
YML007C-A_p YML007C-A YML007C-A hom Uncharacterized 2.24974728477651 0.0122324960290326 no 192 0.0206177877230217 270 NA FF|FT MITOCHONDRION Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria biological_process molecular_function mitochondrion
YBR177C YBR177C EHT1 hom Verified 2.2447752224907 0.0123912830871573 no 193 0.0104436317983563 88 NA FT KETONE METABOLISM|LIPID METABOLISM MITOCHONDRION Acyl-coenzymeA:ethanol O-acyltransferase; plays a minor role in medium-chain fatty acid ethyl ester biosynthesis; possesses short-chain esterase activity; localizes to lipid particles and the mitochondrial outer membrane; EHT1 has a paralog, EEB1, that arose from the whole genome duplication medium-chain fatty acid catabolic process|medium-chain fatty acid biosynthetic process|cellular lipid metabolic process short-chain carboxylesterase activity|alcohol O-butanoyltransferase activity|serine hydrolase activity mitochondrial outer membrane|mitochondrion|lipid particle
YMR244C-A YMR244C-A COA6 hom Verified 2.23825039060201 0.0126023656272601 no 194 0.00784320633127481 66 NA FT NUCLEUS|MITOCHONDRION Protein involved in cytochrome c oxidase assembly; also required for efficient formation of respiratory supercomplexes comprised of Complexes III and IV; localizes to the mitochondrial intermembrane space; has a human homolog; transcription is induced in response to the DNA-damaging agent MMS; protein abundance increases in response to DNA replication stress biological_process molecular_function nucleus|cytoplasm
YOL114C_p YOL114C YOL114C hom Uncharacterized 2.22734617035515 0.0129620735233864 no 195 0.0135845044394386 123 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION Putative protein of unknown function with similarity to human ICT1 and prokaryotic factors that may function in translation termination; YOL114C is not an essential gene biological_process molecular_function cellular_component
YDR263C YDR263C DIN7 hom Verified 2.22382639598232 0.013080063363904 no 196 0.0151793686344245 103 NA FT RESPONSE TO DNA DAMAGE NUCLEUS|MITOCHONDRION Mitochondrial nuclease functioning in DNA repair and replication, modulates the stability of the mitochondrial genome, induced by exposure to mutagens, also induced during meiosis at a time nearly coincident with commitment to recombination DNA repair nuclease activity mitochondrion
YDL225W YDL225W SHS1 hom Verified 2.21010779087567 0.0135488411473157 no 197 0.00562838396042987 76 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH|CYTOSKELETON Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate with other rods to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins; undergoes sumoylation and phosphorylation during mitosis; protein abundance increases in response to DNA replication stress cytokinesis, actomyosin contractile ring assembly|G1 phase of mitotic cell cycle|barrier septum assembly|exit from mitosis|cell cycle cytokinesis|septin ring assembly|cellular bud neck septin ring organization GTP binding cellular bud neck septin ring|mating projection tip
YPL047W YPL047W SGF11 hom Verified 2.20326152947662 0.0137881603962236 no 198 0.013205920679656 122 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION NUCLEUS HISTONE ACETYLTRANSFERASE Integral subunit of SAGA histone acetyltransferase complex, regulates transcription of a subset of SAGA-regulated genes, required for the Ubp8p association with SAGA and for H2B deubiquitylation histone deubiquitination|regulation of transcription from RNA polymerase II promoter enzyme activator activity DUBm complex|nucleus|SAGA complex
YLL023C YLL023C POM33 hom Verified 2.20321222999193 0.0137898968565077 no 199 0.0110767873647226 82 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RNA LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM NUCLEAR PORE Transmembrane nucleoporin; involved in nuclear pore complex (NPC) distribution, assembly or stabilization; highly conserved across species, orthologous to human TMEM33 and paralogous to Per33p; protein abundance increases in response to DNA replication stress nuclear pore organization|nuclear pore complex assembly structural constituent of nuclear pore ribosome|integral to membrane|endoplasmic reticulum|nuclear pore
YLR233C YLR233C EST1 hom Verified 2.19713288685465 0.014005478494924 no 200 0.0120996872851341 59 NA FT NUCLEUS|CHROMOSOME TLC1 RNA-associated factor involved in telomere length regulation as recruitment subunit of telomerase; has G-quadruplex promoting activity that is required for telomere elongation; possible role in activating telomere-bound Est2p-TLC1-RNA telomere maintenance via telomerase|telomere maintenance|G-quadruplex DNA formation single-stranded DNA binding|RNA binding|telomeric DNA binding nucleolus|nucleus|telomerase holoenzyme complex
YDL083C YDL083C RPS16B hom Verified 2.18674873296483 0.0143804359484109 no 201 0.0244591466829495 92 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S16 and bacterial S9; RPS16B has a paralog, RPS16A, that arose from the whole genome duplication cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) structural constituent of ribosome cytosolic small ribosomal subunit
YPL065W YPL065W VPS28 hom Verified 2.18647915876715 0.0143902839137828 no 202 0.0244404809166144 232 NA FF|FT PROTEIN LOCALIZATION|PROTEOLYSIS|VACUOLAR TRANSPORT Component of the ESCRT-I complex (Stp22p, Srn2p, Vps28p, and Mvb12p), which is involved in ubiquitin-dependent sorting of proteins into the endosome; conserved C-terminal domain interacts with ESCRT-III subunit Vps20p protein targeting to membrane|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|protein targeting to vacuole protein complex binding endosome|ESCRT I complex
YOR045W YOR045W TOM6 hom Verified 2.18239722904671 0.0145401143306243 no 203 0.0127387780320533 117 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex mitochondrial outer membrane translocase complex assembly|protein import into mitochondrial matrix protein channel activity mitochondrion|integral to membrane|mitochondrial outer membrane translocase complex
YNL141W YNL141W AAH1 hom Verified 2.18044878742752 0.0146121055424306 no 204 0.0137927416337177 114 NA FT NUCLEOTIDE METABOLISM NUCLEUS Adenine deaminase (adenine aminohydrolase), converts adenine to hypoxanthine; involved in purine salvage; transcriptionally regulated by nutrient levels and growth phase; Aah1p degraded upon entry into quiescence via SCF and the proteasome adenine catabolic process|hypoxanthine salvage|purine-containing compound salvage adenine deaminase activity nucleus|cytoplasm
YDR539W YDR539W FDC1 hom Verified 2.18006533995056 0.0146263092597336 no 205 0.0129361234151602 131 NA FT KETONE METABOLISM|COFACTOR METABOLISM PLASMA MEMBRANE Putative phenylacrylic acid decarboxylase; essential for the decarboxylation of aromatic carboxylic acids to the corresponding vinyl derivatives; homolog of E. coli UbiD; GFP-fusion protein localizes to the cytoplasm cinnamic acid catabolic process molecular_function cytoplasm
YMR031C YMR031C EIS1 hom Verified 2.17874966910081 0.0146751348794011 no 206 0.0176905204662017 98 NA FT PROTEIN COMPLEX ORG/BIOGENESIS MITOCHONDRION|PLASMA MEMBRANE Component of the eisosome required for proper eisosome assembly; similarity to Ykl050cp and Uso1p; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; protein increases in abundance and relocalizes from plasma membrane to cytoplasm upon DNA replication stress eisosome assembly molecular_function eisosome|mitochondrion|membrane raft|cytoplasm
YFR007W YFR007W YFH7 hom Verified 2.17415710261203 0.0148466693729868 no 207 0.0105222665380156 135 NA Putative kinase with similarity to the phosphoribulokinase/uridine kinase/bacterial pantothenate kinase (PRK/URK/PANK) subfamily of P-loop kinases phosphorylation ATPase activity|kinase activity cellular_component
YEL054C YEL054C RPL12A hom Verified 2.16986105543286 0.0150086866899271 no 208 0.0136611345585173 104 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Ribosomal 60S subunit protein L12A; rpl12a rpl12b double mutant exhibits slow growth and slow translation; homologous to mammalian ribosomal protein L12 and bacterial L11; RPL12A has a paralog, RPL12B, that arose from the whole genome duplication cytoplasmic translation|ribosomal large subunit assembly structural constituent of ribosome cytosolic large ribosomal subunit
YPL163C YPL163C SVS1 hom Verified 2.16685129118586 0.0151230975091688 no 209 0.0106576179830981 106 NA Cell wall and vacuolar protein; required for wild-type resistance to vanadate; SVS1 has a paralog, SRL1, that arose from the whole genome duplication response to chemical stimulus molecular_function fungal-type cell wall|fungal-type vacuole
YHL025W YHL025W SNF6 hom Verified 2.16191278505309 0.0153124496706859 no 210 0.0156222763551569 47 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|CARBOHYDRATE METABOLISM NUCLEUS RSC COMPLEX Subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; functions interdependently in transcriptional activation with Snf2p and Snf5p; relocates to the cytosol under hypoxic conditions sucrose catabolic process|nucleotide-excision repair|chromatin remodeling|positive regulation of transcription from RNA polymerase II promoter molecular_function SWI/SNF complex|nucleus
YOL064C YOL064C MET22 hom Verified 2.15733594427509 0.0154897491398643 no 211 0.0285248751042795 163 NA FT KETONE METABOLISM|LIPID METABOLISM|AMINO ACID METABOLISM NUCLEUS Bisphosphate-3'-nucleotidase, involved in salt tolerance and methionine biogenesis; dephosphorylates 3'-phosphoadenosine-5'-phosphate and 3'-phosphoadenosine-5'-phosphosulfate, intermediates of the sulfate assimilation pathway methionine biosynthetic process|hyperosmotic salinity response|sulfate assimilation 3'(2'),5'-bisphosphate nucleotidase activity cellular_component
YNL082W YNL082W PMS1 hom Verified 2.15655621931497 0.015520129446842 no 212 0.0168077996255803 135 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE NUCLEUS ATP-binding protein required for mismatch repair in mitosis and meiosis; functions as a heterodimer with Mlh1p, binds double- and single-stranded DNA via its N-terminal domain, similar to E. coli MutL mismatch repair|meiotic mismatch repair double-stranded DNA binding|DNA insertion or deletion binding|loop DNA binding|single-stranded DNA binding|dinucleotide insertion or deletion binding|ATPase activity|ATP binding nucleus|MutLalpha complex|cytoplasm
YLR253W_p YLR253W YLR253W hom Uncharacterized 2.15604892583848 0.015539922495514 no 213 0.0151436736232386 111 NA FT MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; transcription is periodic during the metabolic cycle; YLR253W is not an essential gene biological_process molecular_function mitochondrion
YNR001C YNR001C CIT1 hom Verified 2.15377031239514 0.0156290944804326 no 214 0.0189089625685187 158 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION Citrate synthase; catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate; the rate-limiting enzyme of the TCA cycle; nuclear encoded mitochondrial protein; CIT1 has a paralog, CIT2, that arose from the whole genome duplication glutamate biosynthetic process|tricarboxylic acid cycle|acetyl-CoA catabolic process|citrate metabolic process citrate (Si)-synthase activity mitochondrion
YBR290W YBR290W BSD2 hom Verified 2.1535451120014 0.0156379313381223 no 215 0.0175898858935309 142 NA FT PROTEIN LOCALIZATION|ION HOMEOSTASIS|PROTEOLYSIS|ION HOMEOSTASIS|VACUOLAR TRANSPORT ENDOPLASMIC RETICULUM Heavy metal ion homeostasis protein, facilitates trafficking of Smf1p and Smf2p metal transporters to the vacuole where they are degraded, controls metal ion transport, prevents metal hyperaccumulation, functions in copper detoxification metal ion transport|ubiquitin-dependent protein catabolic process|protein targeting to vacuole protein binding fungal-type vacuole membrane|integral to membrane|endoplasmic reticulum
YDL075W YDL075W RPL31A hom Verified 2.15348231022674 0.0156403964424924 no 216 0.0298220583254059 171 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L31A; associates with karyopherin Sxm1p; loss of both Rpl31p and Rpl39p confers lethality; homologous to mammalian ribosomal protein L31, no bacterial homolog; RPL31A has a paralog, RPL31B, that arose from the whole genome duplication cytoplasmic translation|regulation of translational fidelity structural constituent of ribosome cytosolic large ribosomal subunit
YHL004W YHL004W MRP4 hom Verified 2.15145134205783 0.0157202962354281 no 217 0.0173069283635566 157 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the small subunit mitochondrial translation structural constituent of ribosome|tRNA binding mitochondrion|mitochondrial small ribosomal subunit
YJL176C YJL176C SWI3 hom Verified 2.14190949038883 0.0161003830139452 no 218 0.0298357924914719 156 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS NUCLEUS RSC COMPLEX Subunit of the SWI/SNF chromatin remodeling complex; SWI/SNF regulates transcription by remodeling chromosomes; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2; relocates to the cytosol under hypoxic conditions cellular alcohol catabolic process|ATP-dependent chromatin remodeling|positive regulation of mating type switching|sucrose catabolic process|carbon catabolite activation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter histone binding|DNA binding SWI/SNF complex|nucleus
YLR093C YLR093C NYV1 hom Verified 2.13723130685454 0.0162895914349029 no 219 0.0129947759707734 89 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION v-SNARE component of the vacuolar SNARE complex involved in vesicle fusion; inhibits ATP-dependent Ca(2+) transport activity of Pmc1p in the vacuolar membrane vesicle-mediated transport|vacuole fusion, non-autophagic|vesicle fusion SNAP receptor activity SNARE complex|fungal-type vacuole membrane
YOR066W YOR066W MSA1 hom Verified 2.13238670873908 0.0164875345651277 no 220 0.0138988919357822 144 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE NUCLEUS Activator of G1-specific transcription factors, MBF and SBF; involved in regulation of the timing of G1-specific gene transcription and cell cycle initiation; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation G1/S transition of mitotic cell cycle|regulation of transcription involved in G1 phase of mitotic cell cycle|regulation of cell size molecular_function nucleus|cytoplasm
YLR431C YLR431C ATG23 hom Verified 2.1269612012462 0.016711653517197 no 221 0.0217443890657497 155 NA FT PROTEIN LOCALIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS Peripheral membrane protein required for the cytoplasm-to-vacuole targeting (Cvt) pathway and efficient macroautophagy; cycles between the phagophore assembly site (PAS) and non-PAS locations; forms a complex with Atg9p and Atg27p protein localization to pre-autophagosomal structure|positive regulation of macroautophagy|CVT pathway molecular_function pre-autophagosomal structure|extrinsic to membrane
YLR451W YLR451W LEU3 hom Verified 2.1261257667831 0.0167463944940415 no 222 0.0152763225721588 116 NA FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS Zinc-knuckle transcription factor, repressor and activator; regulates genes involved in branched chain amino acid biosynthesis and ammonia assimilation; acts as a repressor in leucine-replete conditions and as an activator in the presence of alpha-isopropylmalate, an intermediate in leucine biosynthesis that accumulates during leucine starvation negative regulation of transcription from RNA polymerase II promoter|Unknown|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus
YNL175C YNL175C NOP13 hom Verified 2.12295658180923 0.0168787451737524 no 223 0.0225721918295617 177 NA FT NUCLEUS Nucleolar protein found in preribosomal complexes; contains an RNA recognition motif (RRM); relative distribution to the nucleolus increases upon DNA replication stress biological_process RNA binding nucleolus|preribosome
YLR328W YLR328W NMA1 hom Verified 2.11797269974075 0.017088689910381 no 224 0.0299291225754924 91 NA FT NUCLEOTIDE METABOLISM|COFACTOR METABOLISM NUCLEUS Nicotinic acid mononucleotide adenylyltransferase; catalyzes the transfer of the adenylyl moiety of ATP to nicotinamide mononucleotide to form NAD; involved in pathways of NAD biosynthesis, including the de novo, NAD(+) salvage, and nicotinamide riboside salvage pathways; NMA1 has a paralog, NMA2, that arose from the whole genome duplication NAD biosynthetic process nicotinamide-nucleotide adenylyltransferase activity nucleus|cytoplasm
YDR387C_p YDR387C YDR387C hom Uncharacterized 2.11726183498774 0.0171188160218253 no 225 0.00813054561835038 69 NA Putative transporter, member of the sugar porter family; YDR387C is not an essential gene transport|transmembrane transport substrate-specific transmembrane transporter activity integral to membrane|membrane
YDR319C_p YDR319C YFT2 hom Uncharacterized 2.10898124681876 0.0174731001890932 no 226 0.0171745500971464 139 NA Protein required for normal ER membrane biosynthesis; member of the highly conserved FIT family of proteins involved in triglyceride droplet biosynthesis and homologous to human FIT2; interacts with Sst2p and Hsp82p in high-throughput two-hybrid screens biological_process molecular_function integral to membrane
YGR240C YGR240C PFK1 hom Verified 2.10671737748655 0.0175710424923362 no 227 0.0342301615461497 225 NA FT CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Alpha subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes proton transport|glycolysis 6-phosphofructokinase activity mitochondrion|6-phosphofructokinase complex|cytoplasm
YOL052C-A YOL052C-A DDR2 hom Verified 2.105684795568 0.0176158707087886 no 228 0.0179467172691766 136 NA Multi-stress response protein; expression is activated by a variety of xenobiotic agents and environmental or physiological stresses; DDR2 has a paralog, HOR7, that arose from the whole genome duplication response to stress molecular_function fungal-type vacuole|cytoplasm
YGL262W_p YGL262W YGL262W hom Uncharacterized 2.10308867846515 0.0177290092216833 no 229 0.0123853295067606 82 NA Putative protein of unknown function; null mutant displays elevated sensitivity to expression of a mutant huntingtin fragment or of alpha-synuclein; YGL262W is not an essential gene biological_process molecular_function cellular_component
YDR001C YDR001C NTH1 hom Verified 2.10018774467383 0.0178561645046234 no 230 0.0141489764788961 105 NA FT CARBOHYDRATE METABOLISM Neutral trehalase, degrades trehalose; required for thermotolerance and may mediate resistance to other cellular stresses; may be phosphorylated by Cdc28p; NTH1 has a paralog, NTH2, that arose from the whole genome duplication trehalose catabolic process|response to stress alpha,alpha-trehalase activity cytosol|cytoplasm
YKR098C YKR098C UBP11 hom Verified 2.09750231057407 0.0179745664241753 no 231 0.0180547644585991 127 NA FT PROTEOLYSIS Ubiquitin-specific protease that cleaves ubiquitin from ubiquitinated proteins biological_process ubiquitin-specific protease activity cellular_component
YDR285W YDR285W ZIP1 hom Verified 2.08432931949642 0.0185651110795029 no 232 0.0201248808550029 115 NA FT CELL CYCLE NUCLEUS|CHROMOSOME Transverse filament protein of the synaptonemal complex; required for normal levels of meiotic recombination and pairing between homologous chromosome during meiosis; potential Cdc28p substrate synapsis|reciprocal meiotic recombination chromatin binding|SUMO polymer binding transverse filament
YAL058W YAL058W CNE1 hom Verified 2.08001732613716 0.018761971853958 no 233 0.0159762779145639 143 NA FT PROTEOLYSIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Calnexin; integral membrane ER chaperone involved in folding and quality control of glycoproteins; chaperone activity is inhibited by Mpd1p, with which Cne1p interacts; 24% identical to mammalian calnexin; Ca+ binding not yet shown in yeast protein folding|ER-associated protein catabolic process unfolded protein binding integral to endoplasmic reticulum membrane
YMR221C_p YMR221C YMR221C hom Uncharacterized 2.06753510416425 0.019341879967979 no 234 0.0150680756093131 123 NA FT MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; physical interaction with Atg27p suggests a possible role in autophagy biological_process molecular_function mitochondrion|integral to membrane|fungal-type vacuole
YLL001W YLL001W DNM1 hom Verified 2.06631869243178 0.0193991987794677 no 235 0.0132490370414435 101 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION|PEROXISOME ORGANIZATION MITOCHONDRION Dynamin-related GTPase required for mitochondrial fission and morphology; assembles on the cytoplasmic face of mitochondrial tubules at sites at which division will occur; also participates in endocytosis and regulating peroxisome abundance mitochondrion inheritance|peroxisome fission|mitochondrial fission|chronological cell aging|peroxisome organization|mitochondrion organization|protein homooligomerization protein homodimerization activity|GTPase activity|identical protein binding mitochondrial outer membrane|mitochondrion|peroxisome
YJL213W YJL213W YJL213W hom Verified 2.06342361279234 0.0195361992098168 no 236 0.0142502403401054 102 NA Protein of unknown function that may interact with ribosomes; periodically expressed during the yeast metabolic cycle; phosphorylated in vitro by the mitotic exit network (MEN) kinase complex, Dbf2p/Mob1p biological_process molecular_function ribosome
YML123C YML123C PHO84 hom Verified 2.05995704127279 0.0197013239091352 no 237 0.0437000147149435 245 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE High-affinity inorganic phosphate (Pi) transporter and low-affinity manganese transporter; regulated by Pho4p and Spt7p; mutation confers resistance to arsenate; exit from the ER during maturation requires Pho86p; cells overexpressing Pho84p accumulate heavy metals but do not develop symptoms of metal toxicity phosphate ion transport|manganese ion transport|polyphosphate metabolic process manganese ion transmembrane transporter activity|inorganic phosphate transmembrane transporter activity integral to membrane|integral to plasma membrane
YMR237W YMR237W BCH1 hom Verified 2.05993985308639 0.0197021455843935 no 238 0.0235217923206174 176 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM GOLGI APPARATUS Member of the ChAPs family (Chs5p-Arf1p-binding proteins); members include Bch1p, Bch2p, Bud7p, and Chs6p; ChAPs family proteins form the exomer complex with Chs5p to mediate export of specific cargo proteins from the Golgi to the plasma membrane; may interact with ribosomes; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress; BCH1 has a paralog, BUD7, that arose from the whole genome duplication Golgi to plasma membrane transport|fungal-type cell wall chitin biosynthetic process molecular_function ribosome|clathrin-coated vesicle|exomer complex
YLR096W YLR096W KIN2 hom Verified 2.04900833616463 0.0202306498928669 no 239 0.0222778275409919 156 NA FT VESICLE-MEDIATED TRANSPORT|PROTEIN PHOSPHORYLATION PLASMA MEMBRANE Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin1p protein autophosphorylation|exocytosis|protein phosphorylation protein serine/threonine kinase activity|protein kinase activity plasma membrane
YER166W YER166W DNF1 hom Verified 2.04759290597379 0.0202999525191013 no 240 0.0264445794758447 174 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION|GOLGI APPARATUS|PLASMA MEMBRANE Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase intracellular protein transport|phospholipid translocation|endocytosis|establishment or maintenance of cell polarity phospholipid-translocating ATPase activity|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism mitochondrion|integral to membrane|plasma membrane
YNR066C_p YNR066C YNR066C hom Uncharacterized 2.04718164205024 0.0203201266134334 no 241 0.0252924136677777 190 NA Putative membrane-localized protein of unknown function biological_process molecular_function integral to membrane|membrane
YJL145W YJL145W SFH5 hom Verified 2.0460491609752 0.0203757670649936 no 242 0.0100087109998136 94 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Non-classical phosphatidylinositol transfer protein (PITP); exhibits PI- but not PC-transfer activity; localizes to the peripheral endoplasmic reticulum, cytosol and microsomes; similar to Sec14p; partially relocalizes to the plasma membrane upon DNA replication stress Golgi to plasma membrane protein transport|phosphatidylinositol metabolic process|Unknown|regulation of exocytosis|phospholipid transport phosphatidylinositol transporter activity|phosphatidylcholine transporter activity cell periphery|cytosol|plasma membrane|cortical endoplasmic reticulum
YPR018W YPR018W RLF2 hom Verified 2.03498109445222 0.0209263876469835 no 243 0.0193435373352369 148 NA FT CHROMATIN ORGANIZATION NUCLEUS|CHROMOSOME Largest subunit (p90) of the Chromatin Assembly Complex (CAF-1); chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of the DNA damage checkpoint after DNA repair; and chromatin dynamics during transcription DNA replication-dependent nucleosome assembly histone binding chromosome, centromeric region|nucleus|CAF-1 complex
YEL063C YEL063C CAN1 hom Verified 2.02533603877493 0.0214164351647284 no 244 0.0312466928298449 194 NA FT MITOCHONDRION|PLASMA MEMBRANE Plasma membrane arginine permease; requires phosphatidyl ethanolamine (PE) for localization, exclusively associated with lipid rafts; mutation confers canavanine resistance; CAN1 has a paralog, ALP1, that arose from the whole genome duplication basic amino acid transport|transmembrane transport basic amino acid transmembrane transporter activity|arginine transmembrane transporter activity mitochondrion|integral to membrane|membrane raft|plasma membrane
YDR432W YDR432W NPL3 hom Verified 2.02158138112597 0.0216098085767545 no 245 0.0348899703130981 237 NA FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION NUCLEUS RNA-binding protein; promotes elongation, regulates termination, and carries poly(A) mRNA from nucleus to cytoplasm; has a role in repressing translation initiation by binding eIF4G; required for pre-mRNA splicing; dissociation from mRNAs promoted by Mtr10p; phosphorylated by Sky1p in the cytoplasm; protein abundance increases in response to DNA replication stress translational termination|mRNA export from nucleus|negative regulation of translation|mRNA splicing, via spliceosome|Unknown|positive regulation of transcription elongation from RNA polymerase II promoter mRNA binding|RNA polymerase II core binding|eukaryotic initiation factor 4G binding|poly(A) RNA binding nucleus|cytoplasm
YMR060C YMR060C SAM37 hom Verified 2.01978609481571 0.0217027900526061 no 246 0.0423821371233439 218 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Component of the Sorting and Assembly Machinery (SAM or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their outer membrane insertion; contributes to SAM complex stability mitochondrial outer membrane translocase complex assembly|protein import into mitochondrial outer membrane|phospholipid transport molecular_function mitochondrial outer membrane|mitochondrial sorting and assembly machinery complex|mitochondrion|integral to membrane
YDR332W YDR332W IRC3 hom Verified 2.01855341519871 0.0217668285254554 no 247 0.023586929451984 185 NA FT MITOCHONDRION Putative RNA helicase of the DEAH/D-box family; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion biological_process ATP-dependent RNA helicase activity mitochondrion
YML026C YML026C RPS18B hom Verified 2.01829550808562 0.0217802471323091 no 248 0.0346021880790122 186 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION MITOCHONDRION RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S18 and bacterial S13; RPS18B has a paralog, RPS18A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress cytoplasmic translation|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|rRNA export from nucleus structural constituent of ribosome cytosolic small ribosomal subunit|mitochondrion
YHL046C YHL046C PAU13 hom Verified 2.00680029682059 0.0223854656308026 no 249 0.0141956489715879 115 NA Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions; expression is induced after ethanol shock biological_process molecular_function cellular_component
YDR138W YDR138W HPR1 hom Verified 2.00420557746747 0.0225240216811997 no 250 0.058646962253359 254 NA FT TRANSCRIPTION FROM RNA POL II|RNA PROCESSING|RESPONSE TO DNA DAMAGE|RNA LOCALIZATION NUCLEUS RNA POL II, HOLOENZYME Subunit of THO/TREX complexes that couple transcription elongation with mitotic recombination and with mRNA metabolism and export, subunit of an RNA Pol II complex; regulates lifespan; involved in telomere maintenance; similar to Top1p mRNA 3'-end processing|mRNA export from nucleus|transcription-coupled nucleotide-excision repair|DNA recombination|response to DNA damage stimulus|transcription elongation from RNA polymerase II promoter protein complex scaffold|nucleic acid binding THO complex part of transcription export complex|Cdc73/Paf1 complex|nucleoplasmic THO complex
YDR194C YDR194C MSS116 hom Verified 2.00129222700668 0.0226804534617451 no 251 0.0285948818238518 177 NA FT RNA PROCESSING|TRANSLATION MITOCHONDRION DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing RNA folding|Group I intron splicing|Group II intron splicing RNA binding|RNA strand annealing activity|ATP-dependent RNA helicase activity mitochondrion|mitochondrial matrix
YLR152C_p YLR152C YLR152C hom Uncharacterized 1.99921619222914 0.0227924836698892 no 252 0.0204637608734568 123 NA Putative protein of unknown function; YLR152C is not an essential gene biological_process molecular_function integral to membrane
YFL041W YFL041W FET5 hom Verified 1.9954136081912 0.022998893980543 no 253 0.0128150530343097 81 NA FT ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS PLASMA MEMBRANE Multicopper oxidase, integral membrane protein with similarity to Fet3p; may have a role in iron transport iron ion transport ferroxidase activity fungal-type vacuole membrane|integral to membrane
YLR348C YLR348C DIC1 hom Verified 1.98994545874632 0.0232984719856293 no 254 0.019034378056655 122 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION Mitochondrial dicarboxylate carrier, integral membrane protein, catalyzes a dicarboxylate-phosphate exchange across the inner mitochondrial membrane, transports cytoplasmic dicarboxylates into the mitochondrial matrix dicarboxylic acid transport dicarboxylic acid transmembrane transporter activity mitochondrial envelope|mitochondrion|integral to membrane
YGL119W YGL119W COQ8 hom Verified 1.97955421679913 0.0238768208979792 no 255 0.0309076606256229 170 NA FT KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication ubiquinone biosynthetic process|aerobic respiration molecular_function mitochondrion|extrinsic to mitochondrial inner membrane|mitochondrial matrix
YOR196C YOR196C LIP5 hom Verified 1.97660462010512 0.0240431697590631 no 256 0.0340731350170699 226 NA FT KETONE METABOLISM|LIPID METABOLISM|COFACTOR METABOLISM MITOCHONDRION Protein involved in biosynthesis of the coenzyme lipoic acid, has similarity to E. coli lipoic acid synthase protein lipoylation lipoate synthase activity mitochondrion
YGR275W YGR275W RTT102 hom Verified 1.9759262351838 0.0240815661649943 no 257 0.031294345545787 134 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|CHROMOSOME SEGREGATION NUCLEUS RSC COMPLEX Component of both the SWI/SNF and RSC chromatin remodeling complexes; suggested role in chromosome maintenance; possible weak regulator of Ty1 transposition; protein abundance increases in response to DNA replication stress chromosome segregation|nucleosome disassembly|chromatin remodeling|transcription elongation from RNA polymerase II promoter molecular_function RSC complex|SWI/SNF complex|nucleus
YBR119W YBR119W MUD1 hom Verified 1.96721686316531 0.0245791073679193 no 258 0.0349932700642959 164 NA FT RNA PROCESSING NUCLEUS U1 snRNP A protein, homolog of human U1-A; involved in nuclear mRNA splicing mRNA splicing, via spliceosome U1 snRNA binding|RNA binding U1 snRNP|U2-type prespliceosome
YEL067C_p YEL067C YEL067C hom Uncharacterized 1.96713152504154 0.0245840248449719 no 259 0.0260131571556612 121 NA FT MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process molecular_function mitochondrion
YMR071C YMR071C TVP18 hom Verified 1.96577146292004 0.0246625078106831 no 260 0.0453513246627327 277 NA FF|FT VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; may interact with ribosomes, based on co-purification experiments vesicle-mediated transport molecular_function integral to membrane|integral to Golgi membrane|clathrin-coated vesicle
YPL162C_p YPL162C YPL162C hom Uncharacterized 1.961592263529 0.0249049868544525 no 261 0.0243766970201271 158 NA Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the membrane of vacuole with cell cycle-correlated morphology biological_process molecular_function fungal-type vacuole membrane|integral to membrane
YGR089W YGR089W NNF2 hom Verified 1.95212510034655 0.0254616769284991 no 262 0.0211895452475149 150 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Protein that exhibits physical and genetic interactions with Rpb8p, which is a subunit of RNA polymerases I, II, and III; computational analysis of large-scale protein-protein interaction data suggests a role in chromosome segregation biological_process molecular_function integral to membrane
YCR098C YCR098C GIT1 hom Verified 1.94865344648533 0.0256684124065902 no 263 0.0272116774651585 217 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE Plasma membrane permease, mediates uptake of glycerophosphoinositol and glycerophosphocholine as sources of the nutrients inositol and phosphate; expression and transport rate are regulated by phosphate and inositol availability transmembrane transport|glycerophosphodiester transport glycerophosphodiester transmembrane transporter activity integral to membrane|plasma membrane
YHL017W_p YHL017W YHL017W hom Uncharacterized 1.94818734672288 0.0256962751424799 no 264 0.0160763679203423 110 NA FT GOLGI APPARATUS Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein co-localizes with clathrin-coated vesicles; YHL017W has a paralog, PTM1, that arose from the whole genome duplication biological_process molecular_function integral to membrane|clathrin-coated vesicle
YBL079W YBL079W NUP170 hom Verified 1.94755690126106 0.025734002491103 no 265 0.0399392110674438 244 NA FF|FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA LOCALIZATION|CHROMOSOME SEGREGATION ENDOMEMBRANE SYSTEM|NUCLEUS NUCLEAR PORE Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC assembly and nucleocytoplasmic transport; both Nup170p and NUP157p are similar to human Nup155p; NUP170 has a paralog, NUP157, that arose from the whole genome duplication nucleocytoplasmic transport|chromosome segregation|protein targeting to nuclear inner membrane|mitotic cell cycle spindle assembly checkpoint|nuclear pore complex assembly structural constituent of nuclear pore integral to membrane|nuclear pore|nuclear pore inner ring
YLR455W YLR455W YLR455W hom Verified 1.93848775307583 0.0262818717715185 no 266 0.0344505971319353 206 NA FT NUCLEUS Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO); protein abundance increases in response to DNA replication stress biological_process molecular_function nucleus
YPR043W YPR043W RPL43A hom Verified 1.93641000311348 0.0264087526552325 no 267 0.0157875677382616 137 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L43A; null mutation confers a dominant lethal phenotype; homologous to mammalian ribosomal protein L37A, no bacterial homolog; RPL43A has a paralog, RPL43B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YJL023C YJL023C PET130 hom Verified 1.93429216390585 0.0265386080752556 no 268 0.02484786502663 139 NA FT MITOCHONDRION Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process molecular_function mitochondrion
YIL127C_p YIL127C RRT14 hom Uncharacterized 1.93422401720713 0.0265427953370157 no 269 0.0225965080783053 120 NA FT NUCLEUS Putative protein of unknown function; identified in a screen for mutants with decreased levels of rDNA transcription; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis biological_process molecular_function nucleolus
YGR092W YGR092W DBF2 hom Verified 1.93231373829887 0.0266603968783351 no 270 0.0645756906335273 325 NA FF|FT CELL CYCLE|ION HOMEOSTASIS|PROTEIN PHOSPHORYLATION|ION HOMEOSTASIS SITE OF POLARIZED GROWTH|CYTOSKELETON Ser/Thr kinase involved in transcription and stress response; functions as part of a network of genes in exit from mitosis; localization is cell cycle regulated; activated by Cdc15p during the exit from mitosis; also plays a role in regulating the stability of SWI5 and CLB2 mRNAs; phosphorylates Chs2p to regulate primary septum formation and Hof1p to regulate cytokinesis nuclear division|protein phosphorylation|vacuolar acidification protein serine/threonine kinase activity|protein kinase activity spindle pole body|cellular bud neck
YBR085W YBR085W AAC3 hom Verified 1.91568739946719 0.027702448627625 no 271 0.0195941268043333 121 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION Mitochondrial inner membrane ADP/ATP translocator; exchanges cytosolic ADP for mitochondrially synthesized ATP; expressed under anaerobic conditions; similar to Aac1p; has roles in maintenance of viability and in respiration; AAC3 has a paralog, PET9, that arose from the whole genome duplication heme biosynthetic process|heme transport|anaerobic respiration|transmembrane transport ATP:ADP antiporter activity mitochondrion|integral to membrane|mitochondrial inner membrane
YKR076W YKR076W ECM4 hom Verified 1.91395160862701 0.0278131696072067 no 272 0.0303691605868656 193 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|CELL WALL ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS Omega class glutathione transferase; not essential; similar to Ygr154cp; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm fungal-type cell wall organization|glutathione metabolic process glutathione transferase activity cytoplasm
YIL012W_d YIL012W YIL012W hom Dubious 1.91167960988084 0.0279586506065166 no 273 0.0282400117395674 182 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YER095W YER095W RAD51 hom Verified 1.90591825428369 0.0283304061563121 no 274 0.0456541745979264 258 NA FF|FT CELL CYCLE|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME Strand exchange protein, forms a helical filament with DNA that searches for homology; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; homolog of Dmc1p and bacterial RecA protein strand invasion|telomere maintenance via recombination|heteroduplex formation|meiotic joint molecule formation|reciprocal meiotic recombination|double-strand break repair via single-strand annealing recombinase activity|single-stranded DNA binding|DNA-dependent ATPase activity condensed nuclear chromosome|nuclear chromosome
YML088W YML088W UFO1 hom Verified 1.90100459011458 0.0286507056967719 no 275 0.0218170310140826 154 NA FT RESPONSE TO DNA DAMAGE|PROTEOLYSIS NUCLEUS UBIQUITIN LIGASE COMPLEX F-box receptor protein, subunit of the Skp1-Cdc53-F-box receptor (SCF) E3 ubiquitin ligase complex; binds to phosphorylated Ho endonuclease, allowing its ubiquitylation by SCF and subsequent degradation SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|cellular response to methylmercury|response to DNA damage stimulus ubiquitin-protein ligase activity|protein binding, bridging SCF ubiquitin ligase complex|nucleus|cytoplasm
YDR329C YDR329C PEX3 hom Verified 1.89997126758183 0.0287184451684922 no 276 0.0311796873811532 173 NA FT PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION ENDOPLASMIC RETICULUM Peroxisomal membrane protein (PMP) required for proper localization and stability of PMPs; anchors peroxisome retention factor Inp1p at the peroxisomal membrane; interacts with Pex19p protein import into peroxisome membrane|peroxisome inheritance|ER-dependent peroxisome organization protein binding peroxisomal membrane|endoplasmic reticulum
YOL112W YOL112W MSB4 hom Verified 1.89561175508226 0.029005700861291 no 277 0.0302763334167242 203 NA FT SIGNALING|NUCLEOTIDE METABOLISM|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH GTPase-activating protein of the Ras superfamily that acts primarily on Sec4p, localizes to the bud site and bud tip, has similarity to Msb3p; msb3 msb4 double mutation causes defects in secretion and actin organization actin filament organization Rab GTPase activator activity incipient cellular bud site|polarisome|cellular bud tip
YMR142C YMR142C RPL13B hom Verified 1.89300905330661 0.0291783327596769 no 278 0.0356220617539502 217 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L13B; not essential for viability; homologous to mammalian ribosomal protein L13, no bacterial homolog; RPL13B has a paralog, RPL13A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YOL150C_d YOL150C YOL150C hom Dubious 1.87755568569334 0.0302209863825443 no 279 0.0238675637472684 102 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YJR122W YJR122W IBA57 hom Verified 1.87528246629573 0.0303769371053296 no 280 0.0611316287824497 330 NA FF|FT COFACTOR METABOLISM MITOCHONDRION Mitochondrial matrix protein involved in the incorporation of iron-sulfur clusters into mitochondrial aconitase-type proteins; activates the radical-SAM family members Bio2p and Lip5p; interacts with Ccr4p in the two-hybrid system iron-sulfur cluster assembly molecular_function mitochondrion|mitochondrial matrix
YOL092W YOL092W YPQ1 hom Verified 1.87235215170696 0.0305789500496061 no 281 0.0237575059497065 159 NA Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; member of the PQ-loop family, with seven transmembrane domains; similar to mammalian PQLC2 vacuolar transporter biological_process molecular_function fungal-type vacuole membrane|integral to membrane|cytoplasm
YGL216W YGL216W KIP3 hom Verified 1.86906336074475 0.0308069998724207 no 282 0.0189271484284568 125 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CYTOSKELETON ORGANIZATION NUCLEUS|CYTOSKELETON Kinesin-related motor protein involved in mitotic spindle positioning nuclear migration along microtubule|mitotic spindle disassembly|establishment of mitotic spindle orientation|plus-end specific microtubule depolymerization|mitotic spindle organization in nucleus plus-end-directed microtubule motor activity|tubulin-dependent ATPase activity kinesin complex|cytoplasmic microtubule|nuclear microtubule
YEL043W YEL043W YEL043W hom Verified 1.86860914945828 0.0308386059519581 no 283 0.030086266297111 188 NA FT ENDOPLASMIC RETICULUM Predicted cytoskeleton protein involved in intracellular signalling based on quantitative analysis of protein-protein interaction maps; may interact with ribosomes, based on co-purification studies; contains fibronectin type III domain fold biological_process molecular_function ribosome|endoplasmic reticulum
YGR227W YGR227W DIE2 hom Verified 1.85942001525376 0.0314838134656679 no 284 0.0305942470551536 200 NA FT CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Dolichyl-phosphoglucose-dependent alpha-1,2 glucosyltransferase of the ER, functions in the pathway that synthesizes the dolichol-linked oligosaccharide precursor for N-linked protein glycosylation, has a role in regulation of ITR1 and INO1 dolichol-linked oligosaccharide biosynthetic process|protein N-linked glycosylation dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity integral to membrane|endoplasmic reticulum membrane
YER163C YER163C GCG1 hom Verified 1.85426463373048 0.0318506545980809 no 285 0.0299507122491605 196 NA FT NUCLEUS Gamma-glutamyl cyclotransferase; cleaves the gamma-glutamyl bond of glutathione to yield 5-oxoproline and a Cys-Gly dipeptide; similar to mammalian pro-apoptotic protein ChaC1; expression of mouse ChaC1 in yeast increases apoptosis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; periodically expressed during the metabolic cycle biological_process molecular_function nucleus|cytoplasm
YJL196C YJL196C ELO1 hom Verified 1.8530032628867 0.0319409454909263 no 286 0.0176871664188754 115 NA FT KETONE METABOLISM|LIPID METABOLISM Elongase I, medium-chain acyl elongase; catalyzes carboxy-terminal elongation of unsaturated C12-C16 fatty acyl-CoAs to C16-C18 fatty acids; ELO1 has a paralog, FEN1, that arose from the whole genome duplication fatty acid elongation, unsaturated fatty acid fatty acid elongase activity integral to membrane|membrane
YDL013W YDL013W SLX5 hom Verified 1.8487326668853 0.0322482121213529 no 287 0.0531529767249869 269 NA FT RESPONSE TO DNA DAMAGE NUCLEUS UBIQUITIN LIGASE COMPLEX Subunit of the Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex, stimulated by SUMO-modified substrates; contains a RING domain and two SIMs (SUMO-interacting motifs); forms SUMO-dependent nuclear foci, including DNA repair centers protein sumoylation|telomere maintenance|response to DNA damage stimulus|protein ubiquitination SUMO binding|ubiquitin-protein ligase activity ubiquitin ligase complex|nucleus
YHL027W YHL027W RIM101 hom Verified 1.84754372093593 0.0323341888492633 no 288 0.0670580956921582 380 NA FF|FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|ION HOMEOSTASIS|CELL WALL ORG/BIOGENESIS|CELL DIVISION|ION HOMEOSTASIS NUCLEUS Cys2His2 zinc-finger transcriptional repressor; involved in alkaline responsive gene repression as part of adaptation to a alkaline conditions; involved in cell wall assembly; required for alkaline pH-stimulated haploid invasive growth and sporulation; activated by alkaline-dependent proteolytic processing which results in removal of the C-terminal tail; similar to A. nidulans PacC meiosis|negative regulation of transcription from RNA polymerase II promoter|fungal-type cell wall biogenesis|cellular response to anoxia|response to pH|ascospore formation|barrier septum assembly|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|sequence-specific DNA binding nucleus
YHR206W YHR206W SKN7 hom Verified 1.84577662796933 0.0324623227688854 no 289 0.054372963460394 296 NA FF|FT TRANSCRIPTION FROM RNA POL II|SIGNALING|RESPONSE TO OXIDATIVE STRESS NUCLEUS Nuclear response regulator and transcription factor; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; part of a branched two-component signaling system; required for optimal induction of heat-shock genes in response to oxidative stress; involved in osmoregulation; SKN7 has a paralog, HMS2, that arose from the whole genome duplication response to singlet oxygen|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|transcription, DNA-dependent|response to osmotic stress|regulation of cell size sequence-specific DNA binding|two-component response regulator activity|sequence-specific DNA binding transcription factor activity nucleus
YIL139C YIL139C REV7 hom Verified 1.84248365902698 0.0327022173087087 no 290 0.0278494597834346 151 NA FT RESPONSE TO DNA DAMAGE NUCLEUS|MITOCHONDRION|CHROMOSOME Accessory subunit of DNA polymerase zeta, involved in translesion synthesis during post-replication repair; required for mutagenesis induced by DNA damage; involved in double-strand break repair error-prone translesion synthesis|error-free translesion synthesis DNA-directed DNA polymerase activity nuclear chromatin|mitochondrion|zeta DNA polymerase complex
YHR011W YHR011W DIA4 hom Verified 1.84215537523799 0.0327262128808828 no 291 0.044997946123147 274 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Probable mitochondrial seryl-tRNA synthetase, mutant displays increased invasive and pseudohyphal growth pseudohyphal growth|invasive growth in response to glucose limitation|mitochondrial seryl-tRNA aminoacylation serine-tRNA ligase activity mitochondrion|cytoplasm
YOR222W YOR222W ODC2 hom Verified 1.84007069682714 0.0328789293679529 no 292 0.0223708048640926 178 NA FT MITOCHONDRION Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for use in lysine and glutamate biosynthesis and in lysine catabolism mitochondrial transport dicarboxylic acid transmembrane transporter activity mitochondrion|integral to membrane|mitochondrial inner membrane
YGR162W YGR162W TIF4631 hom Verified 1.83803596265236 0.0330285531113676 no 293 0.0436489551565145 226 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION MITOCHONDRION RIBOSOME Translation initiation factor eIF4G; subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); interacts with Pab1p and with eIF4A (Tif1p); also has a role in biogenesis of the large ribosomal subunit; TIF4631 has a paralog, TIF4632, that arose from the whole genome duplication translational initiation|ribosomal large subunit biogenesis|stress granule assembly translation initiation factor activity mitochondrion|ribosome|eukaryotic translation initiation factor 4F complex|cytoplasmic stress granule
YCR087C-A_p YCR087C-A YCR087C-A hom Uncharacterized 1.8374819528215 0.0330693891477258 no 294 0.0398678866636237 238 NA FT NUCLEUS Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; YCR087C-A is not an essential gene biological_process molecular_function nucleolus
YDR049W YDR049W VMS1 hom Verified 1.83158068913389 0.0335069580160399 no 295 0.0260171386311316 197 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION Component of a Cdc48p-complex involved in protein quality control; exhibits cytosolic and ER-membrane localization, with Cdc48p, during normal growth, and contributes to ER-associated degradation (ERAD) of specific substrates at a step after their ubiquitination; forms a mitochondrially-associated complex with Cdc48p and Npl4p under oxidative stress that is required for ubiquitin-mediated mitochondria-associated protein degradation (MAD); conserved in C. elegans and humans ER-associated protein catabolic process|mitochondria-associated protein catabolic process|nucleus-associated proteasomal ubiquitin-dependent protein catabolic process molecular_function cytosol|mitochondrion|endoplasmic reticulum membrane|Cdc48p-Npl4p-Vms1p AAA ATPase complex|cytoplasm
YJL144W YJL144W YJL144W hom Verified 1.8302556648266 0.0336058587872869 no 296 0.0273348586415111 148 NA Cytoplasmic hydrophilin essential in dessication-rehydration process; expression induced by osmotic stress, starvation and during stationary phase; protein abundance increases in response to DNA replication stress cellular response to water deprivation molecular_function cytoplasm
YBL096C_d YBL096C YBL096C hom Dubious 1.82995370324479 0.033628431001611 no 297 0.0238052168370383 177 NA Non-essential protein of unknown function Unknown Unknown Unknown
YDR143C YDR143C SAN1 hom Verified 1.82967636493341 0.0336491735702891 no 298 0.0309479262776046 104 NA FT PROTEOLYSIS NUCLEUS Ubiquitin-protein ligase; involved in the proteasome-dependent degradation of aberrant nuclear proteins; targets substrates with regions of exposed hydrophobicity containing 5 or more contiguous hydrophobic residues; contains intrinsically disordered regions that contribute to substrate recognition nucleus-associated proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to misfolded protein|response to stress ubiquitin-protein ligase activity nucleus|cytoplasm
YPL127C YPL127C HHO1 hom Verified 1.82839701960473 0.0337449941786098 no 299 0.0263901718009713 156 NA FT CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS|CHROMOSOME Histone H1, linker histone with roles in meiosis and sporulation; decreasing levels early in sporulation may promote meiosis, and increasing levels during sporulation facilitate compaction of spore chromatin; binds to promoters and within genes in mature spores; may be recruited by Ume6p to promoter regions, contributing to transcriptional repression outside of meiosis; suppresses DNA repair involving homologous recombination negative regulation of DNA recombination|negative regulation of chromatin silencing|regulation of transcription, DNA-dependent DNA binding nucleus|nuclear nucleosome
YDR095C_d YDR095C YDR095C hom Dubious 1.82736613341209 0.0338223689002999 no 300 0.036032496372828 147 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YML061C YML061C PIF1 hom Verified 1.82608531932054 0.033918705600655 no 301 0.0495741876087782 269 NA FT RESPONSE TO DNA DAMAGE|MITOCHONDRION ORGANIZATION NUCLEUS|MITOCHONDRION DNA helicase; exists in a nuclear form that acts as a catalytic inhibitor of telomerase; and as a mitochondrial form involved in repair and recombination of mitochondrial DNA; mutations affect zinc and iron homeostasis; regulated by Rad53p-dependent phosphorylation in rho0 cells chromosome organization|negative regulation of telomere maintenance via telomerase|telomere maintenance|mitochondrial genome maintenance|DNA recombination DNA helicase activity|telomerase inhibitor activity mitochondrion|nucleus|mitochondrial membrane
YPL078C YPL078C ATP4 hom Verified 1.82415072112099 0.0340646446218676 no 302 0.0366548186724033 199 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS MITOCHONDRION Subunit b of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; contributes to the oligomerization of the complex; phosphorylated protein complex oligomerization|ATP synthesis coupled proton transport proton-transporting ATPase activity, rotational mechanism mitochondrion|mitochondrial proton-transporting ATP synthase, stator stalk|integral to membrane
YKL040C YKL040C NFU1 hom Verified 1.82249392832164 0.0341900370878735 no 303 0.0227812414128469 129 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS|COFACTOR METABOLISM MITOCHONDRION Protein involved in iron metabolism in mitochondria; similar to NifU, which is a protein required for the maturation of the Fe/S clusters of nitrogenase in nitrogen-fixing bacteria cellular iron ion homeostasis|iron-sulfur cluster assembly|intracellular sequestering of iron ion molecular_function mitochondrion|mitochondrial matrix
YPL264C_p YPL264C YPL264C hom Uncharacterized 1.817723980186 0.0345531653341779 no 304 0.0265710716106994 121 NA Putative membrane protein of unknown function; physically interacts with Hsp82p; YPL264C is not an essential gene biological_process molecular_function integral to membrane
YJL003W YJL003W COX16 hom Verified 1.81634624685521 0.0346586376237963 no 305 0.0344578802537922 165 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial inner membrane protein, required for assembly of cytochrome c oxidase mitochondrial respiratory chain complex IV assembly molecular_function mitochondrion|mitochondrial inner membrane
YIR013C YIR013C GAT4 hom Verified 1.81314854760598 0.0349044565595899 no 306 0.0187898723677739 104 NA FT NUCLEUS Protein containing GATA family zinc finger motifs transcription, DNA-dependent sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity nucleus
YGR235C YGR235C MOS2 hom Verified 1.80728847669787 0.0353586558996368 no 307 0.0410848534057468 193 NA FT MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial inner membrane protein; non-essential component of the mitochondrial inner membrane organizing system (MINOS, MitOS, or MICOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture cristae formation molecular_function mitochondrion|mitochondrial crista junction|integral to mitochondrial inner membrane
YNL184C_p YNL184C YNL184C hom Uncharacterized 1.80723098344974 0.0353631359537183 no 308 0.052850023891834 278 NA Protein of unknown function; expressed at both mRNA and protein levels biological_process molecular_function cellular_component
YBL087C YBL087C RPL23A hom Verified 1.80493159128961 0.0355426937687876 no 309 0.0344680485388068 162 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L23A; homologous to mammalian ribosomal protein L23 and bacterial L14; RPL23A has a paralog, RPL23B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YPL247C_p YPL247C YPL247C hom Uncharacterized 1.79401106524951 0.0364057013516254 no 310 0.0416345822466098 227 NA FT NUCLEUS Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; similar to the petunia WD repeat protein an11; overexpression causes a cell cycle delay or arrest biological_process molecular_function nucleus|cytoplasm
YOL054W YOL054W PSH1 hom Verified 1.79166258349943 0.0365935157759719 no 311 0.042757453819992 219 NA FT PROTEOLYSIS NUCLEUS|CHROMOSOME E3 ubiquitin ligase that mediates poyubiquitination and degradation of centromere-binding protein Cse4p and prevents Cse4p from mislocalizing to euchromatin; ubiquitylation of Cse4p may be antagonized by Scm3p protein ubiquitination involved in ubiquitin-dependent protein catabolic process ubiquitin-protein ligase activity chromosome, centromeric region|nucleus
YDR379W YDR379W RGA2 hom Verified 1.79022572277913 0.0367088157421928 no 312 0.0255265033978675 133 NA FT SIGNALING|CELL DIVISION|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH|CYTOSKELETON GTPase-activating protein for the polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth; regulated by Pho85p and Cdc28p budding cell isotropic bud growth|pheromone-dependent signal transduction involved in conjugation with cellular fusion|actin filament organization|pseudohyphal growth|establishment of cell polarity|small GTPase mediated signal transduction|invasive growth in response to glucose limitation|budding cell apical bud growth Rho GTPase activator activity cellular bud neck split septin rings
YDR321W YDR321W ASP1 hom Verified 1.78344447438344 0.0372569895074924 no 313 0.036407885657719 184 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Cytosolic L-asparaginase, involved in asparagine catabolism; catalyzes hydrolysis of L-asparagine to aspartic acid and ammonia, has an important role in therapy of acute lymphoblastic leukemia; synthesized constitutively asparagine catabolic process asparaginase activity intracellular
YOR367W YOR367W SCP1 hom Verified 1.78192520652598 0.0373807146955919 no 314 0.0494388584520145 231 NA FT CYTOSKELETON ORGANIZATION CYTOSKELETON Component of yeast cortical actin cytoskeleton, binds and cross links actin filaments; originally identified by its homology to calponin (contains a calponin-like repeat) but the Scp1p domain structure is more similar to transgelin actin filament organization|chronological cell aging actin filament binding|protein binding, bridging actin cortical patch
YHR059W YHR059W FYV4 hom Verified 1.780389354481 0.0375061313758242 no 315 0.0328446342209643 191 NA FT MITOCHONDRION Protein of unknown function, required for survival upon exposure to K1 killer toxin biological_process molecular_function mitochondrion
YLR390W-A YLR390W-A CCW14 hom Verified 1.77906230608671 0.0376147738147269 no 316 0.0191257112317754 98 NA FT CELL WALL ORG/BIOGENESIS MITOCHONDRION Covalently linked cell wall glycoprotein, present in the inner layer of the cell wall fungal-type cell wall organization structural constituent of cell wall mitochondrion|fungal-type cell wall
YOR226C YOR226C ISU2 hom Verified 1.76543885220713 0.0387450192655265 no 317 0.0339166000034502 225 NA FT RNA PROCESSING|ION HOMEOSTASIS|ION HOMEOSTASIS|COFACTOR METABOLISM MITOCHONDRION Protein required for synthesis of iron-sulfur proteins; localized to the mitochondrial matrix; performs a scaffolding function in mitochondria during Fe/S cluster assembly; involved in Fe-S cluster assembly for both mitochondrial and cytosolic proteins; isu1 isu2 double mutant is inviable; protein abundance increases in response to DNA replication stress; evolutionarily conserved cellular iron ion homeostasis|iron-sulfur cluster assembly|tRNA wobble uridine modification molecular_function mitochondrial matrix
YLR313C YLR313C SPH1 hom Verified 1.76478738559799 0.0387997527399391 no 318 0.047184512803521 277 NA FT CELL CYCLE|SIGNALING|CELL DIVISION|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH|CYTOSKELETON Protein involved in shmoo formation and bipolar bud site selection; homologous to Spa2p, localizes to sites of polarized growth in a cell cycle dependent- and Spa2p-dependent manner, interacts with MAPKKs Mkk1p, Mkk2p, and Ste7p bipolar cellular bud site selection|pseudohyphal growth|invasive filamentous growth|mating projection assembly molecular_function incipient cellular bud site|cellular bud neck|cellular bud tip|mating projection
YCR005C YCR005C CIT2 hom Verified 1.75463581126263 0.0396608109364166 no 319 0.033412644823887 148 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION Citrate synthase; catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate, peroxisomal isozyme involved in glyoxylate cycle; expression is controlled by Rtg1p and Rtg2p transcription factors; CIT2 has a paralog, CIT1, that arose from the whole genome duplication glyoxylate cycle|glutamate biosynthetic process|citrate metabolic process citrate (Si)-synthase activity mitochondrion|peroxisome
YML073C YML073C RPL6A hom Verified 1.75265921498788 0.0398302602073925 no 320 0.0431018861154512 224 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Ribosomal 60S subunit protein L6A; N-terminally acetylated; binds 5.8S rRNA; homologous to mammalian ribosomal protein L6, no bacterial homolog; RPL6A has a paralog, RPL6B, that arose from the whole genome duplication cytoplasmic translation|ribosomal large subunit assembly structural constituent of ribosome|RNA binding cytosolic large ribosomal subunit
YKR028W YKR028W SAP190 hom Verified 1.75083529639394 0.0399871423859771 no 321 0.0397782452113846 191 NA FT CELL CYCLE|RNA PROCESSING|SIGNALING Protein that forms a complex with the Sit4p protein phosphatase; required for Sit4p function; member of a family of similar proteins including Sap4p, Sap155p, and Sap185p; SAP190 has a paralog, SAP185, that arose from the whole genome duplication TOR signaling cascade|dephosphorylation|G1/S transition of mitotic cell cycle|tRNA wobble uridine modification molecular_function cytoplasm
YDR363W-A YDR363W-A SEM1 hom Verified 1.75011409093117 0.040049314386798 no 322 0.0416741659866433 233 NA FT VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|PROTEOLYSIS|RNA LOCALIZATION NUCLEUS Component of lid subcomplex of the 26S proteasome regulatory subunit; involved in mRNA export mediated by the TREX-2 complex (Sac3p-Thp1p); ortholog of human DSS1; protein abundance increases in response to DNA replication stress proteasome assembly|proteasomal ubiquitin-dependent protein catabolic process|regulation of cell cycle|mRNA export from nucleus|exocytosis|filamentous growth|ubiquitin-dependent protein catabolic process molecular_function cytosol|nucleus|proteasome storage granule|proteasome regulatory particle, lid subcomplex
YHR200W YHR200W RPN10 hom Verified 1.74215183837189 0.0407409394120938 no 323 0.0405124763257412 248 NA FT PROTEOLYSIS Non-ATPase base subunit of the 19S regulatory particle (RP) of the 26S proteasome; N-terminus plays a role in maintaining the structural integrity of the RP; binds selectively to polyubiquitin chains; homolog of the mammalian S5a protein ubiquitin-dependent protein catabolic process structural molecule activity|polyubiquitin binding proteasome complex|proteasome regulatory particle, base subcomplex
YJL059W YJL059W YHC3 hom Verified 1.74154952148125 0.0407936503669079 no 324 0.0324837639443756 195 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS|VACUOLAR TRANSPORT Vacuolar membrane protein involved in the ATP-dependent transport of arginine into the vacuole and possibly in balancing ion homeostasis; homolog of human CLN3 involved in Batten disease (juvenile onset neuronal ceroid lipofuscinosis) basic amino acid transport|regulation of intracellular pH|arginine transport molecular_function integral to membrane|fungal-type vacuole
YNL090W YNL090W RHO2 hom Verified 1.74134591175554 0.0408114815083472 no 325 0.0425687693249359 249 NA FT SIGNALING|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION PLASMA MEMBRANE Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, involved in the establishment of cell polarity and in microtubule assembly microtubule-based process|fungal-type cell wall organization|actin filament organization|establishment of cell polarity|small GTPase mediated signal transduction GTPase activity membrane
YFL044C YFL044C OTU1 hom Verified 1.7398739494022 0.0409405769396762 no 326 0.0251479623252952 136 NA FT PROTEOLYSIS NUCLEUS Deubiquitylation enzyme that binds to the chaperone-ATPase Cdc48p; may contribute to regulation of protein degradation by deubiquitylating substrates that have been ubiquitylated by Ufd2p; member of the Ovarian Tumor (OTU) family; protein abundance increases in response to DNA replication stress protein deubiquitination|regulation of transcription, DNA-dependent ubiquitin-specific protease activity nucleus|cytoplasm
YFR056C_d YFR056C YFR056C hom Dubious 1.73625789928689 0.0412591218815593 no 327 0.0361791364063338 188 NA Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W Unknown Unknown Unknown
YOR358W YOR358W HAP5 hom Verified 1.73596262320209 0.0412852218173417 no 328 0.0336907936555886 198 NA FT TRANSCRIPTION FROM RNA POL II|OXIDATION-REDUCTION PROCESS|RESPONSE TO NUTRIENT LEVELS|GEN. OF PRECURSOR METABOLITES AND ENERGY NUCLEUS Subunit of the heme-activated, glucose-repressed Hap2/3/4/5 CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; required for assembly and DNA binding activity of the complex carbon catabolite activation of transcription from RNA polymerase II promoter|regulation of cellular respiration RNA polymerase II core promoter proximal region sequence-specific DNA binding|DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription CCAAT-binding factor complex
YPR198W YPR198W SGE1 hom Verified 1.73570985753393 0.0413075748185026 no 329 0.0771750783962415 401 NA FF|FT PLASMA MEMBRANE Plasma membrane multidrug transporter of the major facilitator superfamily, acts as an extrusion permease; partial multicopy suppressor of gal11 mutations response to drug|drug transport drug transmembrane transporter activity integral to membrane|integral to plasma membrane
YIL161W_p YIL161W YIL161W hom Uncharacterized 1.73384267814077 0.0414730004329453 no 330 0.0283081307934921 167 NA Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; mRNA is enriched in Scp160p-associated mRNPs; YIL161W is a non-essential gene biological_process molecular_function cytoplasm
YGR038W YGR038W ORM1 hom Verified 1.73267326891241 0.0415768791406902 no 331 0.0674315300794444 264 NA FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Evolutionarily conserved protein, similar to Orm2p, required for resistance to agents that induce unfolded protein response; Orm1p and Orm2p together control membrane biogenesis by coordinating lipid homeostasis with protein quality control cellular sphingolipid homeostasis|negative regulation of sphingolipid biosynthetic process|response to unfolded protein molecular_function integral to membrane|endoplasmic reticulum|SPOTS complex
YOR183W_p YOR183W FYV12 hom Uncharacterized 1.72442908881087 0.0423152050181579 no 332 0.0452697275135732 250 NA Protein of unknown function, required for survival upon exposure to K1 killer toxin biological_process molecular_function cellular_component
YGR160W_d YGR160W YGR160W hom Dubious 1.71931029729575 0.0427789429775199 no 333 0.0379898648592533 164 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YPL110C YPL110C GDE1 hom Verified 1.71879592881221 0.0428257685553399 no 334 0.0423217068759941 200 NA FT LIPID METABOLISM|SIGNALING|CARBOHYDRATE METABOLISM Glycerophosphocholine (GroPCho) phosphodiesterase; hydrolyzes GroPCho to choline and glycerolphosphate, for use as a phosphate source and as a precursor for phosphocholine synthesis; may interact with ribosomes glycerophospholipid catabolic process glycerophosphocholine phosphodiesterase activity ribosome|cytoplasm
YPL159C YPL159C PET20 hom Verified 1.71875311664461 0.0428296678313163 no 335 0.0480609782106265 225 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Mitochondrial protein, required for respiratory growth under some conditions and for stability of the mitochondrial genome aerobic respiration molecular_function mitochondrion
YDR389W YDR389W SAC7 hom Verified 1.71496840040643 0.0431755103039852 no 336 0.0888195667566796 386 NA FF|FT CELL CYCLE|SIGNALING|CYTOSKELETON ORGANIZATION CYTOSKELETON GTPase activating protein (GAP) for Rho1p, involved in signaling to the actin cytoskeleton, null mutations suppress tor2 mutations and temperature sensitive mutations in actin; potential Cdc28p substrate actin filament reorganization involved in cell cycle|small GTPase mediated signal transduction Rho GTPase activator activity intracellular
YDR369C YDR369C XRS2 hom Verified 1.7115065953792 0.0434938173553356 no 337 0.0531183778987045 304 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE NUCLEUS Protein required for DNA repair; component of the Mre11 complex, which is involved in double strand breaks, meiotic recombination, telomere maintenance, and checkpoint signaling double-strand break repair via nonhomologous end joining|meiotic DNA double-strand break formation|base-excision repair|telomere maintenance|sporulation resulting in formation of a cellular spore|double-strand break repair via break-induced replication single-stranded telomeric DNA binding|protein binding, bridging|DNA binding|double-stranded telomeric DNA binding|telomeric DNA binding|G-quadruplex DNA binding nucleus|Mre11 complex
YEL031W YEL031W SPF1 hom Verified 1.7086176886166 0.0437608949673636 no 338 0.0902257126254423 443 NA FF|FT ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION|GOLGI APPARATUS P-type ATPase, ion transporter of the ER membrane; required to maintain normal lipid composition of intracellular compartments and proper targeting of mitochondrial outer membrane tail-anchored proteins; involved in ER function and Ca2+ homeostasis; required for regulating Hmg2p degradation; confers sensitivity to a killer toxin (SMKT) produced by Pichia farinosa KK1 cellular calcium ion homeostasis|transmembrane transport ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism mitochondrion|integral to membrane|endoplasmic reticulum membrane|cis-Golgi network
YBR025C YBR025C OLA1 hom Verified 1.70625847308498 0.0439799830717224 no 339 0.045398783162513 237 NA P-loop ATPase with similarity to human OLA1 and bacterial YchF; identified as specifically interacting with the proteasome; protein abundance increases in response to hydrogen peroxide and to DNA replication stress biological_process ATPase activity cytoplasm
YNL116W YNL116W DMA2 hom Verified 1.70560054298205 0.0440412391117458 no 340 0.064414427982171 259 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION Ubiquitin-protein ligase (E3); controls septin dynamics and the spindle position checkpoint (SPOC) along with functionally redundant ligase Dma1p by regulating the recruitment of Elm1p to the bud neck; regulates levels of the translation initiation factor eIF2 subunit Gcd11p, as well as abundance, localization, and ubiquitination of Cdk inhibitory kinase Swe1p; ortholog of human RNF8 protein, with sequence similarity to human Chfr; contains FHA and RING finger domains establishment of mitotic spindle orientation|protein autoubiquitination|septin ring assembly|mitotic cell cycle spindle assembly checkpoint ubiquitin-protein ligase activity cytoplasm
YGR076C YGR076C MRPL25 hom Verified 1.70494877339053 0.0441019893973108 no 341 0.0554417709359784 263 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit; mutation confers increased replicative lifespan mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YPL201C YPL201C YIG1 hom Verified 1.69999639368431 0.0445658019302463 no 342 0.0468600667377665 245 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY NUCLEUS Protein that interacts with glycerol 3-phosphatase and plays a role in anaerobic glycerol production; localizes to the nucleus and cytosol glycerol biosynthetic process molecular_function cytosol|nucleus
YGL038C YGL038C OCH1 hom Verified 1.69667763428144 0.0448788116812044 no 343 0.0544918404988679 249 NA FT CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS Mannosyltransferase of the cis-Golgi apparatus, initiates the polymannose outer chain elongation of N-linked oligosaccharides of glycoproteins protein N-linked glycosylation alpha-1,6-mannosyltransferase activity|transferase activity, transferring glycosyl groups Golgi cis cisterna
YOL015W YOL015W IRC10 hom Verified 1.69561054696417 0.0449798295328403 no 344 0.0613567329431539 243 NA Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci biological_process molecular_function cellular_component
YHR045W_p YHR045W YHR045W hom Uncharacterized 1.69485174656509 0.0450517741023977 no 345 0.0418844707103501 252 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS ENDOPLASMIC RETICULUM Putative protein of unknown function; possible role in iron metabolism and/or amino acid and carbohydrate metabolism; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum biological_process molecular_function endoplasmic reticulum
YOL044W YOL044W PEX15 hom Verified 1.69313752151217 0.045214646845533 no 346 0.0340722859217015 185 NA FT PROTEIN LOCALIZATION|SIGNALING|PEROXISOME ORGANIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Phosphorylated tail-anchored type II integral peroxisomal membrane protein required for peroxisome biogenesis, cells lacking Pex15p mislocalize peroxisomal matrix proteins to cytosol, overexpression results in impaired peroxisome assembly protein import into peroxisome matrix, receptor recycling protein anchor integral to peroxisomal membrane
YBR047W_p YBR047W FMP23 hom Uncharacterized 1.69148300705154 0.0453722952919961 no 347 0.0415848111391744 221 NA FT MITOCHONDRION Putative protein of unknown function; proposed to be involved in iron or copper homeostasis; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process molecular_function mitochondrion
YMR026C YMR026C PEX12 hom Verified 1.69119037569104 0.0454002242824367 no 348 0.0599856182078833 222 NA FT PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION C3HC4-type RING-finger peroxin and E3 ubiquitin ligase, required for peroxisome biogenesis and peroxisomal matrix protein import; forms translocation subcomplex with Pex2p and Pex10p; mutations in human homolog cause peroxisomal disorder protein import into peroxisome matrix ubiquitin-protein ligase activity|protein binding integral to peroxisomal membrane
YDR348C YDR348C PAL1 hom Verified 1.6883943659021 0.0456677756422908 no 349 0.0441304919616539 236 NA FT SITE OF POLARIZED GROWTH|PLASMA MEMBRANE Protein of unknown function thought to be involved in endocytosis; Pal1p physically interacts with Ede1p and is found at endocytic sites at the cell periphery during the early stages of endocytosis; green fluorescent protein (GFP)-fusion protein also localizes to the bud neck; potential Cdc28p substrate; similar to the S. pombe Pal1 protein; relocalizes from bud neck to cytoplasm upon DNA replication stress biological_process molecular_function cell cortex|cellular bud neck|mating projection tip
YEL037C YEL037C RAD23 hom Verified 1.68513885079192 0.0459808927542606 no 350 0.0449540924851683 201 NA FT RESPONSE TO DNA DAMAGE|PROTEOLYSIS NUCLEUS|MITOCHONDRION Protein with ubiquitin-like N terminus, subunit of Nuclear Excision Repair Factor 2 (NEF2) with Rad4p that binds damaged DNA; enhances protein deglycosylation activity of Png1p; also involved, with Rad4p, in ubiquitylated protein turnover proteasomal ubiquitin-dependent protein catabolic process|nucleotide-excision repair, DNA damage recognition|ER-associated protein catabolic process|protein deglycosylation damaged DNA binding|ubiquitin binding|peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity|protein binding, bridging proteasome complex|mitochondrion|nucleotide-excision repair factor 2 complex
YLL053C_p YLL053C YLL053C hom Uncharacterized 1.68426211502055 0.0460655117965262 no 351 0.0343304141391749 172 NA Putative protein; in the Sigma 1278B strain background YLL053C is contiguous with AQY2 which encodes an aquaporin biological_process molecular_function integral to membrane
YLR098C YLR098C CHA4 hom Verified 1.68338320895552 0.0461504658169215 no 352 0.048338436446868 188 NA FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS DNA binding transcriptional activator, mediates serine/threonine activation of the catabolic L-serine (L-threonine) deaminase (CHA1); Zinc-finger protein with Zn[2]-Cys[6] fungal-type binuclear cluster domain positive regulation of transcription, DNA-dependent|cellular amino acid catabolic process sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity nucleus
YBR072C-A_p YBR072C-A YBR072C-A hom Uncharacterized 1.6738805815317 0.0470770356321799 no 353 0.0428313661163997 217 NA Putative protein of unknown function; identified by fungal homology and RT-PCR biological_process molecular_function cellular_component
YLR400W_d YLR400W YLR400W hom Dubious 1.67142509424854 0.0473188713556318 no 354 0.0441898464783638 189 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YJL098W YJL098W SAP185 hom Verified 1.66824181289374 0.0476338667938499 no 355 0.0436277919510727 225 NA FT CELL CYCLE|RNA PROCESSING MITOCHONDRION Protein that forms a complex with the Sit4p protein phosphatase; required for Sit4p function; member of a family of similar proteins including Sap4p, Sap155p, and Sap190p; SAP185 has a paralog, SAP190, that arose from the whole genome duplication tRNA wobble uridine modification|G1/S transition of mitotic cell cycle protein serine/threonine phosphatase activity mitochondrion|cytoplasm
YDR277C YDR277C MTH1 hom Verified 1.6642589607119 0.0480303449450476 no 356 0.0410562187473183 152 NA FT SIGNALING Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation glucose transport|signal transduction molecular_function cellular_component
YDR015C_d YDR015C YDR015C hom Dubious 1.66322820211567 0.0481333821879082 no 357 0.0387958876557485 192 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene HED1/YDR014W-A Unknown Unknown Unknown
YDL035C YDL035C GPR1 hom Verified 1.66023696669382 0.0484333953352068 no 358 0.067406013926265 288 NA FT SIGNALING PLASMA MEMBRANE Plasma membrane G protein coupled receptor (GPCR) that interacts with the heterotrimeric G protein alpha subunit, Gpa2p, and with Plc1p; sensor that integrates nutritional signals with the modulation of cell fate via PKA and cAMP synthesis replicative cell aging|G-protein coupled receptor signaling pathway|sucrose mediated signaling|glucose mediated signaling pathway|pseudohyphal growth|hexose mediated signaling|invasive growth in response to glucose limitation|detection of glucose|detection of sucrose stimulus G-protein coupled receptor activity|glucose binding integral to membrane|plasma membrane
YDL178W YDL178W DLD2 hom Verified 1.65725709934504 0.0487337534022373 no 359 0.0779432221571938 316 NA FT KETONE METABOLISM|OXIDATION-REDUCTION PROCESS MITOCHONDRION D-lactate dehydrogenase, located in the mitochondrial matrix lactate metabolic process actin binding|D-lactate dehydrogenase (cytochrome) activity mitochondrion|mitochondrial matrix
YNL049C YNL049C SFB2 hom Verified 1.65695438439904 0.0487643489146193 no 360 0.0387812977484819 193 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS Component of the Sec23p-Sfb2p heterodimer of the COPII vesicle coat, required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sec24p and Sfb3p cargo loading into COPII-coated vesicle signal sequence binding COPII vesicle coat
YOL007C YOL007C CSI2 hom Verified 1.6567909783261 0.0487808708063892 no 361 0.0445053396771648 215 NA FT SITE OF POLARIZED GROWTH Protein of unknown function; green fluorescent protein (GFP)- fusion protein localizes to the mother side of the bud neck and the vacuole; YOL007C is not an essential gene biological_process molecular_function fungal-type vacuole|cellular bud neck
YNL255C YNL255C GIS2 hom Verified 1.64901367518026 0.0495724165719327 no 362 0.0504061825538053 256 NA FT TRANSLATION RIBOSOME Translational activator for mRNAs with internal ribosome entry sites; associates with polysomes and binds to a specific subset of mRNAs; localizes to RNA processing bodies (P bodies) and to stress granules; may have a role in translation regulation under stress conditions; ortholog of human ZNF9/CNBP, a gene involved in myotonic dystrophy type 2 positive regulation of translation mRNA binding|translation regulator activity|single-stranded DNA binding polysomal ribosome|cytoplasm
YER185W YER185W PUG1 hom Verified 1.64336650770405 0.0501535626770943 no 363 0.0491265830906245 225 NA FT PLASMA MEMBRANE Plasma membrane protein with roles in the uptake of protoprophyrin IX and the efflux of heme; expression is induced under both low-heme and low-oxygen conditions; member of the fungal lipid-translocating exporter (LTE) family of proteins heme transport molecular_function integral to membrane|plasma membrane
YGL228W YGL228W SHE10 hom Verified 1.64126180208789 0.0503715408154304 no 364 0.0478626852852994 242 NA FT MITOCHONDRION Putative glycosylphosphatidylinositol (GPI)-anchored protein of unknown function; overexpression causes growth arrest biological_process molecular_function cellular_component
YIL155C YIL155C GUT2 hom Verified 1.63304113778876 0.0512301724762733 no 365 0.0396782279805697 198 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM MITOCHONDRION Mitochondrial glycerol-3-phosphate dehydrogenase; expression is repressed by both glucose and cAMP and derepressed by non-fermentable carbon sources in a Snf1p, Rsf1p, Hap2/3/4/5 complex dependent manner NADH oxidation|replicative cell aging|glycerol metabolic process glycerol-3-phosphate dehydrogenase activity mitochondrion|integral to mitochondrial outer membrane
YJR116W_p YJR116W TDA4 hom Uncharacterized 1.63077201611771 0.0514692171352668 no 366 0.0214735689994765 136 NA Putative protein of unknown function; null mutant is sensitive to expression of the top1-T722A allele biological_process molecular_function integral to membrane
YKR029C YKR029C SET3 hom Verified 1.62701144217831 0.0518673338345317 no 367 0.055575495444759 283 NA FT CELL CYCLE|CHROMATIN ORGANIZATION NUCLEUS|CHROMOSOME Defining member of the SET3 histone deacetylase complex which is a meiosis-specific repressor of sporulation genes; necessary for efficient transcription by RNAPII; one of two yeast proteins that contains both SET and PHD domains; SET3 has a paralog, SET4, that arose from the whole genome duplication negative regulation of meiosis|regulation of transcription, DNA-dependent|histone deacetylation methylated histone residue binding Rpd3L-Expanded complex|Set3 complex
YNR032W YNR032W PPG1 hom Verified 1.62449140862462 0.0521354862540359 no 368 0.0467126913818498 193 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY NUCLEUS Putative serine/threonine protein phosphatase of the type 2A-like phosphatase family, required for glycogen accumulation; interacts with Tap42p, which binds to and regulates other protein phosphatases glycogen metabolic process|protein dephosphorylation protein serine/threonine phosphatase activity nucleus|cytoplasm
YPL072W YPL072W UBP16 hom Verified 1.62435444312352 0.0521500920089659 no 369 0.0414743248950595 212 NA FT PROTEOLYSIS MITOCHONDRION Deubiquitinating enzyme anchored to the outer mitochondrial membrane, probably not important for general mitochondrial functioning, but may perform a more specialized function at mitochondria protein deubiquitination ubiquitin-specific protease activity mitochondrial outer membrane|cytoplasm
YNL196C_p YNL196C SLZ1 hom Uncharacterized 1.62205068212467 0.0523962483414398 no 370 0.0593965275790777 308 NA Sporulation-specific protein with a leucine zipper motif biological_process molecular_function cellular_component
YMR075C-A_d YMR075C-A YMR075C-A hom Dubious 1.62047552311197 0.0525650840524326 no 371 0.052414610375241 222 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF RCO1/YMR075W Unknown Unknown Unknown
YMR161W YMR161W HLJ1 hom Verified 1.61708737109231 0.0529297112590586 no 372 0.0610202809105789 250 NA FT PROTEOLYSIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Co-chaperone for Hsp40p, anchored in the ER membrane; with its homolog Ydj1p promotes ER-associated protein degradation (ERAD) of integral membrane substrates; similar to E. coli DnaJ ER-associated protein catabolic process ATPase activator activity endoplasmic reticulum|endoplasmic reticulum membrane
YJL047C YJL047C RTT101 hom Verified 1.61276404781102 0.0533978898647166 no 373 0.0713886716943269 338 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|PROTEOLYSIS NUCLEUS UBIQUITIN LIGASE COMPLEX Cullin subunit of a Roc1p-dependent E3 ubiquitin ligase complex with a role in anaphase progression; implicated in Mms22-dependent DNA repair; involved with Mms1p in nonfunctional rRNA decay; modified by the ubiquitin-like protein, Rub1p replication fork processing|negative regulation of transposition, RNA-mediated|regulation of mitosis|nonfunctional rRNA decay|ubiquitin-dependent protein catabolic process ubiquitin-protein ligase activity Cul8-RING ubiquitin ligase complex|nucleus|cytoplasm
YHR064C YHR064C SSZ1 hom Verified 1.61210806990727 0.0534692124883139 no 374 0.044850594354792 251 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION Hsp70 protein that interacts with Zuo1p (a DnaJ homolog) to form a ribosome-associated complex that binds the ribosome via the Zuo1p subunit; also involved in pleiotropic drug resistance via sequential activation of PDR1 and PDR5; binds ATP cytoplasmic translation|regulation of translational fidelity|rRNA processing unfolded protein binding polysome|cytoplasm
YAR015W YAR015W ADE1 hom Verified 1.60936870079323 0.0537678724919621 no 375 0.0525759773923003 264 NA FT NUCLEOTIDE METABOLISM NUCLEUS N-succinyl-5-aminoimidazole-4-carboxamide ribotide (SAICAR) synthetase, required for 'de novo' purine nucleotide biosynthesis; red pigment accumulates in mutant cells deprived of adenine; protein abundance increases in response to DNA replication stress purine nucleotide biosynthetic process|'de novo' IMP biosynthetic process phosphoribosylaminoimidazolesuccinocarboxamide synthase activity nucleus|cytoplasm
YOR216C YOR216C RUD3 hom Verified 1.60627413358754 0.0541068455343399 no 376 0.053307041125369 301 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT GOLGI APPARATUS Golgi matrix protein involved in the structural organization of the cis-Golgi; interacts genetically with COG3 and USO1 ER to Golgi vesicle-mediated transport molecular_function Golgi apparatus
YHL020C YHL020C OPI1 hom Verified 1.60621239177707 0.0541136257851937 no 377 0.0657603288161484 305 NA FT TRANSCRIPTION FROM RNA POL II|LIPID METABOLISM|SIGNALING ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM Transcriptional regulator of a variety of genes; phosphorylation by protein kinase A stimulates Opi1p function in negative regulation of phospholipid biosynthetic genes; involved in telomere maintenance endoplasmic reticulum unfolded protein response|negative regulation of transcription from RNA polymerase II promoter|phospholipid biosynthetic process|positive regulation of transcription from RNA polymerase II promoter transcription corepressor activity nuclear membrane|nucleoplasm|nuclear envelope|endoplasmic reticulum|nucleus
YCR084C YCR084C TUP1 hom Verified 1.60292816246122 0.0544752575911927 no 378 0.0494160854585539 224 NA FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|LIPID METABOLISM|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|RESPONSE TO NUTRIENT LEVELS NUCLEUS General repressor of transcription, forms complex with Cyc8p, involved in the establishment of repressive chromatin structure through interactions with histones H3 and H4, appears to enhance expression of some genes nucleosome positioning|regulation of transcription from RNA polymerase II promoter in response to osmotic stress|histone exchange|negative regulation of mating-type specific transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter by glucose|negative regulation of dipeptide transport by negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter in response to hypoxia|negative regulation of transcription from RNA polymerase II promoter during mitosis|Unknown ubiquitin binding|histone deacetylase binding|histone binding|phosphatidylinositol-3,5-bisphosphate binding|RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription|mediator complex binding nucleus|transcriptional repressor complex
YOR071C YOR071C NRT1 hom Verified 1.59699379775256 0.0551335448809196 no 379 0.0466734362109394 225 NA FT PLASMA MEMBRANE High-affinity nicotinamide riboside transporter; also transports thiamine with low affinity; shares sequence similarity with Thi7p and Thi72p; proposed to be involved in 5-fluorocytosine sensitivity thiamine transport|nicotinamide riboside transport nicotinamide riboside transporter activity integral to membrane|plasma membrane
YPL133C YPL133C RDS2 hom Verified 1.59105767842964 0.0557982979111591 no 380 0.0359413517452803 180 NA FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|SIGNALING|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS NUCLEUS Transcription factor involved in regulating gluconeogenesis and glyoxylate cycle genes; member of the zinc cluster family of proteins; confers resistance to ketoconazole positive regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source|positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter|cellular response to xenobiotic stimulus|positive regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus|cytoplasm
YDR441C YDR441C APT2 hom Verified 1.58939523821666 0.0559855944927379 no 381 0.0493253546956089 236 NA Potential adenine phosphoribosyltransferase; encodes a protein with similarity to adenine phosphoribosyltransferase, but artificially expressed protein exhibits no enzymatic activity; APT2 has a paralog, APT1, that arose from the whole genome duplication biological_process adenine phosphoribosyltransferase activity|molecular_function cytoplasm
YPL194W YPL194W DDC1 hom Verified 1.58840961962613 0.0560968718188588 no 382 0.046612619372762 211 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME DNA damage checkpoint protein; part of a PCNA-like complex required for DNA damage response, required for pachytene checkpoint to inhibit cell cycle in response to unrepaired recombination intermediates; potential Cdc28p substrate; forms nuclear foci upon DNA replication stress meiosis|mitotic cell cycle G1/S transition checkpoint|intra-S DNA damage checkpoint|recombinational repair|G2/M transition checkpoint|cell cycle checkpoint molecular_function condensed nuclear chromosome|checkpoint clamp complex
YDL006W YDL006W PTC1 hom Verified 1.5867947137779 0.0562795732410777 no 383 0.122885273297348 481 NA FF|FT RNA PROCESSING|SIGNALING|MITOCHONDRION ORGANIZATION|PROTEIN PHOSPHORYLATION NUCLEUS Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p, inactivating osmosensing MAPK cascade; involved in Fus3p activation during pheromone response; deletion affects precursor tRNA splicing, mitochondrial inheritance, and sporulation mitochondrion inheritance|inactivation of MAPK activity involved in osmosensory signaling pathway|pheromone-dependent signal transduction involved in conjugation with cellular fusion|tRNA splicing, via endonucleolytic cleavage and ligation|protein dephosphorylation protein serine/threonine phosphatase activity nucleus|cytoplasm
YPR058W YPR058W YMC1 hom Verified 1.58335183615327 0.0566706471195946 no 384 0.0461479352652359 198 NA FT MITOCHONDRION Putative mitochondrial inner membrane transporter; proposed role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; YMC1 has a paralog, YMC2, that arose from the whole genome duplication mitochondrial transport organic acid transmembrane transporter activity mitochondrion|integral to membrane
YOR368W YOR368W RAD17 hom Verified 1.58040586520953 0.0570069746220618 no 385 0.0558244100829756 266 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME Checkpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints; with Mec3p and Ddc1p, forms a clamp that is loaded onto partial duplex DNA; homolog of human and S. pombe Rad1 and U. maydis Rec1 proteins double-strand break repair|reciprocal meiotic recombination|DNA damage checkpoint double-stranded DNA binding nucleus|checkpoint clamp complex
YNL214W YNL214W PEX17 hom Verified 1.58020430069993 0.057030043602312 no 386 0.0672267227191423 275 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|PEROXISOME ORGANIZATION Peroxisomal membrane peroxin and subunit of the docking complex that facilitates the import of peroxisomal matrix proteins; required for peroxisome biogenesis protein import into peroxisome matrix, docking protein binding peroxisomal membrane
YHR032W YHR032W ERC1 hom Verified 1.57949593497743 0.0571111740900486 no 387 0.0596594791699098 237 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM Member of the multi-drug and toxin extrusion (MATE) family of the multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter superfamily; overproduction confers ethionine resistance and accumulation of S-adenosylmethionine S-adenosylmethionine biosynthetic process|transmembrane transport antiporter activity integral to membrane
YNL248C YNL248C RPA49 hom Verified 1.57825652040069 0.0572533451418403 no 388 0.0567887031802676 247 NA FT NUCLEUS RNA polymerase I subunit A49 transcription elongation from RNA polymerase I promoter|transcription of nuclear large rRNA transcript from RNA polymerase I promoter|regulation of cell size molecular_function DNA-directed RNA polymerase I complex
YOR288C YOR288C MPD1 hom Verified 1.5763604477515 0.0574713790650793 no 389 0.0424272718535699 203 NA FT ENDOPLASMIC RETICULUM Member of the protein disulfide isomerase (PDI) family; interacts with and inhibits the chaperone activity of Cne1p; MPD1 overexpression in a pdi1 null mutant suppresses defects in Pdi1p functions such as carboxypeptidase Y maturation protein folding protein disulfide oxidoreductase activity|protein disulfide isomerase activity fungal-type vacuole
YMR096W YMR096W SNZ1 hom Verified 1.57535010081011 0.0575878277454751 no 390 0.0373208345539332 153 NA FT COFACTOR METABOLISM Protein involved in vitamin B6 biosynthesis; member of a stationary phase-induced gene family; coregulated with SNO1; interacts with Sno1p and with Yhr198p, perhaps as a multiprotein complex containing other Snz and Sno proteins pyridoxine metabolic process|thiamine biosynthetic process protein binding cellular_component
YEL042W YEL042W GDA1 hom Verified 1.57443098665666 0.0576939224077607 no 391 0.0524842969076096 237 NA FT CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Guanosine diphosphatase located in the Golgi, involved in the transport of GDP-mannose into the Golgi lumen by converting GDP to GMP after mannose is transferred its substrate protein glycosylation guanosine-diphosphatase activity|uridine-diphosphatase activity Golgi apparatus
YPL051W YPL051W ARL3 hom Verified 1.57314115171634 0.0578430690218483 no 392 0.0918204448494358 430 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING ENDOMEMBRANE SYSTEM|GOLGI APPARATUS GTPase of the Ras superfamily required to recruit Arl1p to the Golgi; similar to ADP-ribosylation factor intracellular protein transport|Golgi to plasma membrane protein transport|protein localization to organelle GTPase activity Golgi apparatus|nuclear outer membrane-endoplasmic reticulum membrane network
YDR209C_d YDR209C YDR209C hom Dubious 1.57313857385037 0.0578433674096968 no 393 0.0479401856610608 214 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized gene YDR210W. Unknown Unknown Unknown
YOR365C_p YOR365C YOR365C hom Uncharacterized 1.57284124021716 0.0578777918814926 no 394 0.0450235321714512 255 NA Putative protein of unknown function; not an essential protein; YOR365C has a paralog, FLC2, that arose from the whole genome duplication biological_process molecular_function integral to membrane
YBR187W_p YBR187W GDT1 hom Uncharacterized 1.5700867362739 0.0581974669428606 no 395 0.0624457982260089 317 NA Putative protein of unknown function; expression is reduced in a gcr1 null mutant; GFP-fusion protein localizes to the vacuole; expression pattern and physical interactions suggest a possible role in ribosome biogenesis biological_process molecular_function integral to membrane|fungal-type vacuole
YAL029C YAL029C MYO4 hom Verified 1.56677820622171 0.0585832716112704 no 396 0.0561670763900649 253 NA FT RNA LOCALIZATION MITOCHONDRION|SITE OF POLARIZED GROWTH|CYTOSKELETON Type V myosin motor involved in actin-based transport of cargos; required for mRNA transport, including ASH1 mRNA, and facilitating the growth and movement of ER tubules into the growing bud along with She3p; MYO4 has a paralog, MYO2, that arose from the whole genome duplication mating type switching|endoplasmic reticulum inheritance|intracellular mRNA localization microfilament motor activity|actin filament binding mitochondrion|filamentous actin|myosin V complex|cellular bud|cellular bud tip
YMR224C YMR224C MRE11 hom Verified 1.56340772649641 0.0589783619803327 no 397 0.0650725760784694 308 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE NUCLEUS|MITOCHONDRION Subunit of the MRX complex with Rad50p and Xrs2p; complex functions in repair of DNA double-strand breaks and in telomere stability; exhibits nuclease activity that appears to be required for MRX function; widely conserved; forms nuclear foci upon DNA replication stress DNA repair|meiotic DNA double-strand break formation|double-strand break repair via nonhomologous end joining|base-excision repair|ascospore formation|meiotic DNA double-strand break processing|double-strand break repair via break-induced replication|regulation of transcription during meiosis 3'-5' exonuclease activity|protein complex scaffold|double-stranded telomeric DNA binding|adenylate kinase activity|telomeric DNA binding|single-stranded telomeric DNA binding|endodeoxyribonuclease activity|G-quadruplex DNA binding|endonuclease activity mitochondrion|nucleus|Mre11 complex
YML124C YML124C TUB3 hom Verified 1.56296221956567 0.0590307407134702 no 398 0.126851143166927 529 NA FF|FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|NUCLEOTIDE METABOLISM|CHROMOSOME SEGREGATION NUCLEUS|CYTOSKELETON Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; expressed at lower level than Tub1p; TUB3 has a paralog, TUB1, that arose from the whole genome duplication nuclear migration along microtubule|nuclear migration involved in conjugation with cellular fusion|homologous chromosome segregation|mitotic sister chromatid segregation structural constituent of cytoskeleton tubulin complex|cytoplasmic microtubule|kinetochore microtubule|nuclear microtubule|spindle pole body|polar microtubule
YPR109W_p YPR109W YPR109W hom Uncharacterized 1.5628317248416 0.0590460900276206 no 399 0.0725162929597328 282 NA FT CELL CYCLE Predicted membrane protein; dipoid deletion strain has high budding index biological_process molecular_function cellular_component
YCR090C_p YCR090C YCR090C hom Uncharacterized 1.55593723400983 0.0598615091702708 no 400 0.0361743658398989 232 NA FT NUCLEUS Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YCR090C is not an essential gene biological_process molecular_function nucleus|cytoplasm
YOL019W-A_p YOL019W-A YOL019W-A hom Uncharacterized 1.55548048223905 0.0599158397116785 no 401 0.0441307023092234 202 NA Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching biological_process molecular_function cellular_component
YER059W YER059W PCL6 hom Verified 1.54930566294731 0.0606541295463183 no 402 0.0467049668197844 242 NA FT CELL CYCLE|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION|GEN. OF PRECURSOR METABOLITES AND ENERGY NUCLEUS Pho85p cyclin of the Pho80p subfamily; forms the major Glc8p kinase together with Pcl7p and Pho85p; involved in the control of glycogen storage by Pho85p; stabilized by Elongin C binding regulation of glycogen catabolic process|regulation of glycogen biosynthetic process cyclin-dependent protein kinase regulator activity cyclin-dependent protein kinase holoenzyme complex
YIL107C YIL107C PFK26 hom Verified 1.54891148286064 0.0607015000935031 no 403 0.070260232866962 293 NA FT CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY 6-phosphofructo-2-kinase, inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate; has negligible fructose-2,6-bisphosphatase activity; transcriptional regulation involves protein kinase A regulation of glycolysis|fructose 2,6-bisphosphate metabolic process 6-phosphofructo-2-kinase activity cytoplasm
YJL013C YJL013C MAD3 hom Verified 1.54756384871817 0.06086367046923 no 404 0.0469033263116587 206 NA FT CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION NUCLEUS Subunit of the spindle-assembly checkpoint complex, which delays anaphase onset in cells with defects in mitotic spindle assembly; pseudosubstrate inhibitor of APC(Cdc20), the anaphase promoting complex involved in securin (Pds1p) turnover distributive segregation|mitotic cell cycle spindle assembly checkpoint|mitotic cell cycle G2/M transition decatenation checkpoint molecular_function mitotic checkpoint complex
YMR247W-A_p YMR247W-A YMR247W-A hom Uncharacterized 1.54717923501243 0.0609100158487339 no 405 0.05769713910608 280 NA Putative protein of unknown function biological_process molecular_function cellular_component
YDR244W YDR244W PEX5 hom Verified 1.54625713721752 0.0610212396310461 no 406 0.0797808848487936 258 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|PEROXISOME ORGANIZATION Peroxisomal membrane signal receptor for the C-terminal tripeptide signal sequence (PTS1) of peroxisomal matrix proteins, required for peroxisomal matrix protein import; also proposed to have PTS1-receptor independent functions protein import into peroxisome matrix, docking peroxisome matrix targeting signal-1 binding|protein binding, bridging cytosol|peroxisomal membrane|peroxisome
YGL194C YGL194C HOS2 hom Verified 1.54291779647976 0.061425361129652 no 407 0.055397626110474 258 NA FT CELL CYCLE|CHROMATIN ORGANIZATION|SIGNALING NUCLEUS|CHROMOSOME Histone deacetylase and subunit of Set3 and Rpd3L complexes; required for gene activation via specific deacetylation of lysines in H3 and H4 histone tails; subunit of the Set3 complex, a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity; co-localizes with Cmr1p in nuclear foci in response to DNA damage by MMS negative regulation of meiosis|chromatin organization|regulation of transcription, DNA-dependent|positive regulation of stress-activated MAPK cascade|histone deacetylation NAD-independent histone deacetylase activity|NAD-dependent histone deacetylase activity Rpd3L-Expanded complex|Set3 complex
YDR125C YDR125C ECM18 hom Verified 1.53899858103687 0.06190232132877 no 408 0.087692823441758 334 NA FT CELL WALL ORG/BIOGENESIS MITOCHONDRION Protein of unknown function; ECM18 has a paralog, ICT1, that arose from the whole genome duplication fungal-type cell wall organization molecular_function mitochondrion
YBR072W YBR072W HSP26 hom Verified 1.53862838100723 0.0619475228838255 no 409 0.0543613190880904 272 NA FT NUCLEUS Small heat shock protein (sHSP) with chaperone activity; forms hollow, sphere-shaped oligomers that suppress unfolded proteins aggregation; oligomer activation requires heat-induced conformational change; also has mRNA binding activity protein folding|response to stress unfolded protein binding|mRNA binding nucleus|cytoplasm
YKL053C-A YKL053C-A MDM35 hom Verified 1.53742362173747 0.0620948027471263 no 410 0.0708458349171736 302 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION NUCLEUS|MITOCHONDRION Mitochondrial intermembrane space protein; mutation affects mitochondrial distribution and morphology; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress mitochondrion organization|mitochondrial respiratory chain complex assembly molecular_function nucleus|cytoplasm|mitochondrial intermembrane space
YCR100C_p YCR100C YCR100C hom Uncharacterized 1.53532727522964 0.0623517287988365 no 411 0.0792370007106299 304 NA Putative protein of unknown function biological_process molecular_function integral to membrane
YDR153C YDR153C ENT5 hom Verified 1.53237586198429 0.0627148552200131 no 412 0.049581075829212 184 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p, clathrin adaptor complex AP-1, and clathrin late endosome to vacuole transport via multivesicular body sorting pathway|early endosome to Golgi transport|Golgi to endosome transport clathrin binding|phosphatidylinositol-3,5-bisphosphate binding endosome|clathrin vesicle coat|cytoplasm
YPL152W-A_p YPL152W-A YPL152W-A hom Uncharacterized 1.531649913882 0.062804424130608 no 413 0.0502909573859028 198 NA Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching biological_process molecular_function cellular_component
YMR100W YMR100W MUB1 hom Verified 1.53013185307042 0.0629920476061208 no 414 0.0772685774214552 306 NA FT CELL DIVISION MYND domain-containing protein required for ubiquitination and turnover of Rpn4p; interacts with Ubr2p (E3) and indirectly with Rad6p (E2); short-lived protein degraded in a Ubr2p/Rad6p dependent manner; similar to the A. nidulans samB gene regulation of cell budding|protein monoubiquitination molecular_function cellular_component
YKR007W YKR007W MEH1 hom Verified 1.5297516395497 0.0630391080865856 no 415 0.0740358317146764 368 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; loss results in a defect in vacuolar acidification microautophagy|vacuolar acidification molecular_function fungal-type vacuole membrane|EGO complex|late endosome membrane
YMR192W YMR192W GYL1 hom Verified 1.52501969733274 0.0636270923791261 no 416 0.0487728399553491 203 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING|NUCLEOTIDE METABOLISM MITOCHONDRION|GOLGI APPARATUS|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE Putative GTPase activating protein (GAP) with a role in exocytosis; stimulates Gyp5p GAP activity on Ypt1p, colocalizes with Gyp5p at sites of polarized growth; interacts with Gyp5p, Rvs161p, and Rvs167p; involved in recruiting Rvs167p to the bud tip during polarized growth; increases in abundance and relocalizes from bud neck to cytoplasm upon DNA replication stress ER to Golgi vesicle-mediated transport|regulation of exocytosis protein binding mitochondrion|incipient cellular bud site|cellular bud|cellular bud neck|cellular bud tip|cytoplasm|Golgi-associated vesicle|plasma membrane
YPR156C YPR156C TPO3 hom Verified 1.52284853395649 0.063898302141691 no 417 0.0495066059191839 254 NA FT PLASMA MEMBRANE Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; specific for spermine; localizes to the plasma membrane; TPO3 has a paralog, TPO2, that arose from the whole genome duplication spermine transport spermine transmembrane transporter activity fungal-type vacuole membrane|integral to membrane|plasma membrane
YNL301C YNL301C RPL18B hom Verified 1.52251424692879 0.0639401391850924 no 418 0.0488609362354474 233 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L18B; homologous to mammalian ribosomal protein L18, no bacterial homolog; RPL18B has a paralog, RPL18A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YNL070W YNL070W TOM7 hom Verified 1.52125944743192 0.0640973712509822 no 419 0.077760912232335 367 NA FF|FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex protein import into mitochondrial matrix|protein import into mitochondrial outer membrane protein channel activity mitochondrial outer membrane|mitochondrion|integral to membrane|mitochondrial outer membrane translocase complex
YLR262C-A YLR262C-A TMA7 hom Verified 1.51723423096898 0.0646037783243639 no 420 0.0591504188337527 299 NA FT TRANSLATION NUCLEUS Protein of unknown that associates with ribosomes; null mutant exhibits translation defects, altered polyribosome profiles, and resistance to the translation inhibitor anisomcyin; protein abundance increases in response to DNA replication stress cytoplasmic translation molecular_function nucleus|cytoplasm
YER098W YER098W UBP9 hom Verified 1.5131518308588 0.0651205482528697 no 421 0.0772022223697106 342 NA FT PROTEOLYSIS Ubiquitin-specific protease that cleaves ubiquitin-protein fusions; UBP9 has a paralog, UBP13, that arose from the whole genome duplication protein deubiquitination ubiquitin-specific protease activity cytoplasm
YDR283C YDR283C GCN2 hom Verified 1.51256330963112 0.065195309933924 no 422 0.121897100244877 581 NA FF|FT KETONE METABOLISM|CELL CYCLE|AMINO ACID METABOLISM|RESPONSE TO DNA DAMAGE|TRANSLATION|PROTEIN PHOSPHORYLATION RIBOSOME Protein kinase, phosphorylates the alpha-subunit of translation initiation factor eIF2 (Sui2p) in response to starvation; activated by uncharged tRNAs and the Gcn1p-Gcn20p complex; contributes to DNA damage checkpoint control cellular amino acid biosynthetic process|protein phosphorylation|regulation of translational initiation|DNA damage checkpoint protein homodimerization activity|protein kinase activity|eukaryotic translation initiation factor 2alpha kinase activity cytosolic ribosome
YMR032W YMR032W HOF1 hom Verified 1.50883214699891 0.0656708416399511 no 423 0.0681515755983744 373 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CELL DIVISION SITE OF POLARIZED GROWTH|CYTOSKELETON Bud neck-localized, SH3 domain-containing protein required for cytokinesis; is phosphorylated by Dbf2p; regulates actomyosin ring dynamics and septin localization; interacts with the formins, Bni1p and Bnr1p, and with Cyk3p, Vrp1p, and Bni5p cytokinesis after mitosis|barrier septum assembly involved in cell cycle cytokinesis|response to DNA damage stimulus|cytokinesis cytoskeletal protein binding cellular bud neck contractile ring|cellular bud neck septin ring
YKL149C YKL149C DBR1 hom Verified 1.5080609121598 0.0657694690237862 no 424 0.0620845691726058 270 NA FT RNA PROCESSING NUCLEUS RNA lariat debranching enzyme, involved in intron turnover; required for efficient Ty1 transposition snoRNA metabolic process|pseudohyphal growth|RNA catabolic process|transposition, RNA-mediated RNA lariat debranching enzyme activity nucleus
YHR079C YHR079C IRE1 hom Verified 1.50653568602378 0.0659648566618481 no 425 0.0853283909453101 348 NA FF|FT RNA PROCESSING|SIGNALING|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM Serine-threonine kinase and endoribonuclease; transmembrane protein that mediates the unfolded protein response (UPR) by regulating Hac1p synthesis through HAC1 mRNA splicing; Kar2p binds inactive Ire1p and releases from it upon ER stress endoplasmic reticulum unfolded protein response|fungal-type cell wall organization|inositol metabolic process|protein phosphorylation unfolded protein binding|protein serine/threonine kinase activity|endoribonuclease activity|protein kinase activity|protein homodimerization activity nucleus
YBR064W_d YBR064W YBR064W hom Dubious 1.50318531962832 0.066395631045998 no 426 0.0535525840385181 252 NA Dubious open reading frame unlikely to encode a protein; partially overlaps the uncharacterized ORF YBR063C Unknown Unknown Unknown
YHL011C YHL011C PRS3 hom Verified 1.5003664036987 0.0667597585823969 no 427 0.0830395863219855 412 NA FF|FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes fungal-type cell wall organization|5-phosphoribose 1-diphosphate biosynthetic process|regulation of cell size ribose phosphate diphosphokinase activity cytoplasm
YNL212W YNL212W VID27 hom Verified 1.49708284388041 0.0671858516116518 no 428 0.0659289352266126 298 NA Cytoplasmic protein of unknown function; possibly involved in vacuolar protein degradation; not essential for proteasome-dependent degradation of fructose-1,6-bisphosphatase (FBPase); null mutants exhibit normal growth biological_process molecular_function cytoplasm
YOR139C_d YOR139C YOR139C hom Dubious 1.49688891517187 0.067211082493559 no 429 0.0871262313588896 345 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SFL1/YOR140W Unknown Unknown Unknown
YDR192C YDR192C NUP42 hom Verified 1.4953198603178 0.0674154921576703 no 430 0.062420141459159 261 NA FT PROTEIN LOCALIZATION|RNA LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS NUCLEAR PORE FG-nucleoporin component of central core of the nuclear pore complex (NPC); also part of the NPC cytoplasmic filaments; contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier and is involved in gene tethering at the nuclear periphery; interacts with Gle1p poly(A)+ mRNA export from nucleus|NLS-bearing substrate import into nucleus|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|mRNA export from nucleus in response to heat stress|transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery nucleocytoplasmic transporter activity|structural constituent of nuclear pore nuclear pore central transport channel|integral to membrane|nuclear pore cytoplasmic filaments|nuclear pore
YLR454W_p YLR454W FMP27 hom Uncharacterized 1.4928265638018 0.0677412959774338 no 431 0.0597026605182655 315 NA FT MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process molecular_function mitochondrion
YOR112W YOR112W CEX1 hom Verified 1.48581611495454 0.0686638832194238 no 432 0.069560312068574 298 NA FT RNA LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS Cytoplasmic component of the nuclear aminoacylation-dependent tRNA export pathway; interacts with nuclear pore component Nup116p; copurifies with tRNA export receptors Los1p and Msn5p, as well as eIF-1a and the RAN GTPase Gsp1p tRNA export from nucleus tRNA binding nuclear pore|cytoplasm
YBL075C YBL075C SSA3 hom Verified 1.48291410032622 0.0690486173311718 no 433 0.0762548488427802 384 NA FT PROTEIN LOCALIZATION ATPase involved in protein folding and the response to stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasm; SSA3 has a paralog, SSA4, that arose from the whole genome duplication protein folding|SRP-dependent cotranslational protein targeting to membrane, translocation|response to stress unfolded protein binding|ATPase activity cytosol
YLR211C_p YLR211C YLR211C hom Uncharacterized 1.4801297939211 0.0694193059054164 no 434 0.0563606873094516 234 NA Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR211C is not an essential gene; ORF contains an intron biological_process molecular_function cytoplasm
YMR183C YMR183C SSO2 hom Verified 1.47995043519595 0.0694432372706058 no 435 0.0582284726164992 283 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION ENDOPLASMIC RETICULUM|PLASMA MEMBRANE Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane; syntaxin homolog that is functionally redundant with Sso1p Golgi to plasma membrane transport|ascospore-type prospore assembly|vesicle fusion phosphatidic acid binding|SNAP receptor activity endoplasmic reticulum|plasma membrane|prospore membrane|cytoplasm
YJL051W YJL051W IRC8 hom Verified 1.47755143091937 0.0697639412887281 no 436 0.0456255403508188 207 NA Bud tip localized protein of unknown function; mRNA is targeted to the bud by a She2p dependent transport system; mRNA is cell cycle regulated via Fkh2p, peaking in G2/M phase; null mutant displays increased levels of spontaneous Rad52p foc mitotic recombination molecular_function integral to membrane|cellular bud
YGR049W YGR049W SCM4 hom Verified 1.47581211383192 0.0699971689174273 no 437 0.0765237588921156 247 NA FT MITOCHONDRION Mitochondrial outer membrane protein of unknown function; predicted to have 4 transmembrane segments; import is mediated by Tom70p and Mim1p; interacts genetically with a cdc4 mutation biological_process molecular_function mitochondrial outer membrane|mitochondrion|integral to membrane
YKL038W YKL038W RGT1 hom Verified 1.47385345887123 0.0702605255294286 no 438 0.0990675137371186 383 NA FT TRANSCRIPTION FROM RNA POL II|CARBOHYDRATE METABOLISM NUCLEUS Glucose-responsive transcription factor; regulates expression of several glucose transporter (HXT) genes in response to glucose; binds to promoters and acts both as a transcriptional activator and repressor; RGT1 has a paralog, EDS1, that arose from the whole genome duplication glucose transport|regulation of glucose import|negative regulation of transcription from RNA polymerase II promoter|glucose metabolic process|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription nucleus
YAL045C_d YAL045C YAL045C hom Dubious 1.47259910910787 0.0704295825912859 no 439 0.052507748669876 208 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps YAL044W-A Unknown Unknown Unknown
YDR193W_d YDR193W YDR193W hom Dubious 1.46921530357681 0.0708872003597417 no 440 0.0467343385820214 221 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YDR457W YDR457W TOM1 hom Verified 1.46735032401961 0.0711403902583059 no 441 0.05517688530029 292 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|RIBOSOME BIOGENESIS|PROTEOLYSIS|RNA LOCALIZATION NUCLEUS E3 ubiquitin ligase of the hect-domain class; has a role in mRNA export from the nucleus and may regulate transcriptional coactivators; involved in degradation of excess histones; interacts with Dia2p and is required for Dia2p degradation; required to target Cdc6p for ubiquitin-mediated destruction during G1 phase endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|mitosis|nucleocytoplasmic transport|nucleus organization|cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|regulation of cell size|protein ubiquitination ubiquitin-protein ligase activity integral to membrane|nucleolus|nucleus
YDR271C_d YDR271C YDR271C hom Dubious 1.46303163379601 0.0717293615854767 no 442 0.103872500473534 436 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CCC2/YDR270W Unknown Unknown Unknown
YML009W-B_d YML009W-B YML009W-B hom Dubious 1.45880471410695 0.0723094323805702 no 443 0.0748216640127946 347 NA Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion mutation confers an increase in Ty1 transposition Unknown Unknown Unknown
YBR255W YBR255W MTC4 hom Verified 1.45651428057226 0.0726252524031867 no 444 0.0946924571116716 360 NA Protein of unknown function, required for normal growth rate at 15 degrees C; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; mtc4 is synthetically sick with cdc13-1 biological_process molecular_function cytoplasm
YPL191C_p YPL191C YPL191C hom Uncharacterized 1.45639904479808 0.0726411697371549 no 445 0.0670967831472524 302 NA Putative protein of unknown function; diploid deletion strain exhibits high budding index; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm biological_process molecular_function cytoplasm
YDR237W YDR237W MRPL7 hom Verified 1.45195938411325 0.0732564494724369 no 446 0.0903938183382094 382 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit; MRPL7 produces both YmL5 and YmL7, which are two different modified forms of the same protein mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YLL018C-A YLL018C-A COX19 hom Verified 1.45166950953082 0.0732967605872094 no 447 0.0888888917712839 323 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS MITOCHONDRION Protein required for cytochrome c oxidase assembly, located in the cytosol and mitochondrial intermembrane space; putative copper metallochaperone that delivers copper to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs mitochondrial respiratory chain complex IV assembly|metal ion transport copper ion binding|copper chaperone activity cytosol|mitochondrial intermembrane space
YPR201W YPR201W ARR3 hom Verified 1.4513337120022 0.0733434791415003 no 448 0.0621058850021995 305 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE Plasma membrane metalloid/H+ antiporter; transports arsenite and antimonite; required for resistance to arsenic compounds; transcription is activated by Arr1p in the presence of arsenite arsenite transport|antimonite transport antiporter activity|arsenite transmembrane transporter activity|antimonite transmembrane transporter activity integral to membrane|plasma membrane
YDR152W YDR152W GIR2 hom Verified 1.45034218763009 0.0734815600300631 no 449 0.0744835787749947 334 NA FT TRANSLATION Highly-acidic cytoplasmic RWD domain-containing protein of unknown function; forms a complex with Rbg2p; interacts with Rbg1p and Gcn1p; associates with translating ribosomes; putative intrinsically unstructured protein cytoplasmic translation molecular_function polysome|cytoplasm
YEL071W YEL071W DLD3 hom Verified 1.44980714165317 0.0735561537182447 no 450 0.0681411681529449 250 NA FT KETONE METABOLISM|OXIDATION-REDUCTION PROCESS D-lactate dehydrogenase, part of the retrograde regulon which consists of genes whose expression is stimulated by damage to mitochondria and reduced in cells grown with glutamate as the sole nitrogen source, located in the cytoplasm lactate metabolic process|filamentous growth D-lactate dehydrogenase (cytochrome) activity cytoplasm
YDL068W_d YDL068W YDL068W hom Dubious 1.44352307585623 0.0744365884214074 no 451 0.0971821370827101 372 NA Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YGR255C YGR255C COQ6 hom Verified 1.44100990064482 0.0747909428760943 no 452 0.079047653335303 348 NA FT KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM MITOCHONDRION Putative flavin-dependent monooxygenase; involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; human COX6 can rescue a yeast cox6 mutant and is implicated in steroid-resistant nephrotic syndrome (SRNS) ubiquinone biosynthetic process N,N-dimethylaniline monooxygenase activity mitochondrion|mitochondrial inner membrane
YOR059C YOR059C YOR059C hom Verified 1.44060148171602 0.0748486507939305 no 453 0.0572151036556613 247 NA FT LIPID METABOLISM Lipid particle protein of unknown function; contains a putative lipase serine active site; induced by transcription factor Rpn4p; protein abundance increases in response to DNA replication stress biological_process molecular_function lipid particle
YER083C YER083C GET2 hom Verified 1.4373705052181 0.0753063724583061 no 454 0.150627979909416 591 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS Subunit of the GET complex; involved in insertion of proteins into the ER membrane; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for meiotic nuclear division retrograde vesicle-mediated transport, Golgi to ER|protein insertion into ER membrane protein anchor integral to membrane|endoplasmic reticulum|GET complex
YMR262W_p YMR262W YMR262W hom Uncharacterized 1.43251907170374 0.0759976619919066 no 455 0.0699568163849189 329 NA Protein of unknown function; interacts weakly with Knr4p; YMR262W is not an essential gene biological_process molecular_function cellular_component
YJL036W YJL036W SNX4 hom Verified 1.43208471769633 0.0760597887636586 no 456 0.109434681062316 440 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT Sorting nexin, involved in retrieval of late-Golgi SNAREs from post-Golgi endosomes to the trans-Golgi network and in cytoplasm to vacuole transport; contains a PX phosphoinositide-binding domain; forms complexes with Snx41p and with Atg20p piecemeal microautophagy of nucleus|mitochondrion degradation|early endosome to Golgi transport|CVT pathway|protein targeting to vacuole phosphatidylinositol-3-phosphate binding cytosol|pre-autophagosomal structure|extrinsic to membrane|early endosome
YDL135C YDL135C RDI1 hom Verified 1.43091867915176 0.0762267614749124 no 457 0.0479677157955836 206 NA FT MEMBRANE ORGANIZATION|SIGNALING|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH Rho GDP dissociation inhibitor; involved in the localization and regulation of Cdc42p and Rho1p; protein abundance increases in response to DNA replication stress regulation of vacuole fusion, non-autophagic|actin filament organization|small GTPase mediated signal transduction Rho GDP-dissociation inhibitor activity cytosol|plasma membrane|cellular bud neck|cellular bud tip
YGR138C YGR138C TPO2 hom Verified 1.42763426478865 0.0766985778895152 no 458 0.0396303048780149 196 NA FT PLASMA MEMBRANE Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; specific for spermine; localizes to the plasma membrane; transcription of TPO2 is regulated by Haa1p; TPO2 has a paralog, TPO3, that arose from the whole genome duplication spermine transport spermine transmembrane transporter activity fungal-type vacuole membrane|integral to membrane|plasma membrane
YGR035W-A_p YGR035W-A YGR035W-A hom Uncharacterized 1.42742464434927 0.0767287657466146 no 459 0.061066122483035 261 NA Putative protein of unknown function biological_process molecular_function cellular_component
YBR297W YBR297W MAL33 hom Verified 1.42718813073789 0.0767628373900286 no 460 0.0768527691743705 316 NA FT TRANSCRIPTION FROM RNA POL II|CARBOHYDRATE METABOLISM NUCLEUS MAL-activator protein, part of complex locus MAL3; nonfunctional in genomic reference strain S288C cellular carbohydrate metabolic process|regulation of transcription, DNA-dependent sequence-specific DNA binding transcription factor activity nucleus
YLL026W YLL026W HSP104 hom Verified 1.42531306765004 0.0770333622011161 no 461 0.0789838944486964 281 NA FT PROTEIN LOCALIZATION|CARBOHYDRATE METABOLISM|RESPONSE TO OXIDATIVE STRESS NUCLEUS Disaggregase; heat shock protein that cooperates with Ydj1p (Hsp40) and Ssa1p (Hsp70) to refold and reactivate previously denatured, aggregated proteins; responsive to stresses including: heat, ethanol, and sodium arsenite; involved in [PSI+] propagation; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress trehalose metabolism in response to heat stress|protein folding in endoplasmic reticulum|protein unfolding|chaperone cofactor-dependent protein refolding|inheritance of oxidatively modified proteins involved in replicative cell aging|cellular heat acclimation ADP binding|unfolded protein binding|ATPase activity, coupled|chaperone binding|ATP binding TRC complex|nucleus|cytoplasm
YLR441C YLR441C RPS1A hom Verified 1.42467768091438 0.0771251968276458 no 462 0.0964466989811324 352 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Ribosomal protein 10 (rp10) of the small (40S) subunit; homologous to mammalian ribosomal protein S3A, no bacterial homolog; RPS1A has a paralog, RPS1B, that arose from the whole genome duplication cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) structural constituent of ribosome cytosolic small ribosomal subunit|90S preribosome
YBR078W YBR078W ECM33 hom Verified 1.42430520270768 0.0771790710475974 no 463 0.148479174703571 517 NA FF|FT CELL WALL ORG/BIOGENESIS MITOCHONDRION|PLASMA MEMBRANE GPI-anchored protein of unknown function, has a possible role in apical bud growth; GPI-anchoring on the plasma membrane crucial to function; phosphorylated in mitochondria; similar to Sps2p and Pst1p fungal-type cell wall organization molecular_function mitochondrion|fungal-type cell wall|plasma membrane
YOR140W YOR140W SFL1 hom Verified 1.42101545607289 0.0776561330908854 no 464 0.0744205480137614 312 NA FT TRANSCRIPTION FROM RNA POL II|GENE SILENCING NUCLEUS Transcriptional repressor and activator; involved in repression of flocculation-related genes, and activation of stress responsive genes; negatively regulated by cAMP-dependent protein kinase A subunit Tpk2p gene silencing|Unknown|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II repressing transcription factor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity nucleus
YJL064W_d YJL064W YJL064W hom Dubious 1.42070164705159 0.0777017567557225 no 465 0.07228437156802 319 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene YJL065C/DLS1 Unknown Unknown Unknown
YGR063C YGR063C SPT4 hom Verified 1.42056835219446 0.0777211422140014 no 466 0.131571484083908 492 NA FF|FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|RNA LOCALIZATION|CHROMOSOME SEGREGATION|GENE SILENCING NUCLEUS|CHROMOSOME Component of the universally conserved Spt4/5 complex (DSIF complex); the complex has multiple roles in concert with RNA polymerases I and II, including regulation of transcription elongation, RNA processing, quality control, and transcription-coupled DNA repair; Spt4p also localizes to kinetochores and heterochromatin and affects chromosome dynamics and silencing; required for transcription through lengthy trinucleotide repeats in ORFs or non-protein coding regions 7-methylguanosine mRNA capping|chromosome segregation|chromatin organization|intracellular mRNA localization|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription, DNA-dependent|regulation of transcription-coupled nucleotide-excision repair|chromatin silencing|mRNA splicing, via spliceosome|Unknown core RNA polymerase I binding transcription factor activity|core RNA polymerase II binding transcription factor activity|rDNA binding DSIF complex|nuclear telomeric heterochromatin|rDNA heterochromatin|mating-type region heterochromatin|kinetochore
YIL165C_p YIL165C YIL165C hom Uncharacterized 1.41976732780397 0.0778377148476768 no 467 0.0625701780837137 268 NA Putative protein of unknown function; mutant exhibits mitophagy defects; in closely related species and other S. cerevisiae strain backgrounds YIL165C and adjacent ORF, YIL164C, likely constitute a single ORF encoding a nitrilase gene mitochondrion degradation molecular_function cellular_component
YNR031C YNR031C SSK2 hom Verified 1.4186460694494 0.0780011137651956 no 468 0.0753283242762359 333 NA FT SIGNALING|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION SITE OF POLARIZED GROWTH MAP kinase kinase kinase of the HOG1 mitogen-activated signaling pathway; interacts with Ssk1p, leading to autophosphorylation and activation of Ssk2p which phosphorylates Pbs2p; also mediates actin cytoskeleton recovery from osmotic stress MAPK cascade involved in osmosensory signaling pathway|protein autophosphorylation|protein phosphorylation|response to osmotic stress|actin cytoskeleton organization|osmosensory signaling pathway via two-component system MAP kinase kinase kinase activity cytosol|cellular bud neck|cellular bud tip
YPL079W YPL079W RPL21B hom Verified 1.41606484363155 0.078378260070563 no 469 0.0714767399043517 320 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L21B; homologous to mammalian ribosomal protein L21, no bacterial homolog; RPL21B has a paralog, RPL21A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YDR220C_d YDR220C YDR220C hom Dubious 1.41455604472568 0.0785993520744266 no 470 0.0614513154514668 258 NA Dubious open reading frame, null mutant exhibits synthetic phenotype with alpha-synuclein Unknown Unknown Unknown
YKR087C YKR087C OMA1 hom Verified 1.41438607824185 0.0786242877252572 no 471 0.0792765023456034 354 NA FT PROTEOLYSIS MITOCHONDRION Metalloendopeptidase of the mitochondrial inner membrane; involved in turnover of membrane-embedded proteins; mediates degradation of Cox1p in coa2 mutant cells; member of a family of predicted membrane-bound metallopeptidases in prokaryotes and higher eukaryotes misfolded or incompletely synthesized protein catabolic process metalloendopeptidase activity mitochondrion|mitochondrial inner membrane
YDR418W YDR418W RPL12B hom Verified 1.41239698658487 0.078916551630463 no 472 0.0749850292001057 345 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Ribosomal 60S subunit protein L12B; rpl12a rpl12b double mutant exhibits slow growth and slow translation; homologous to mammalian ribosomal protein L12 and bacterial L11; RPL12B has a paralog, RPL12A, that arose from the whole genome duplication cytoplasmic translation|ribosomal large subunit assembly structural constituent of ribosome cytosolic large ribosomal subunit
YLR128W YLR128W DCN1 hom Verified 1.41097798212767 0.07912555316445 no 473 0.0937210434291744 338 NA Scaffold-type E3 ligase required for cullin neddylation and ubiquitin ligase activation; contains a ubiquitin-binding domain (UBA) for ubiquitin and Nedd8 (Rub1p) interaction and a PONY domain involved in cullin binding and neddylation protein neddylation|positive regulation of ubiquitin-protein ligase activity ubiquitin binding|NEDD8 ligase activity|small conjugating protein binding cellular_component
YDR420W YDR420W HKR1 hom Verified 1.4075618609873 0.0796304237384244 no 474 0.0561300826865056 234 NA FT CELL CYCLE|SIGNALING|CELL WALL ORG/BIOGENESIS|CELL DIVISION|CARBOHYDRATE METABOLISM SITE OF POLARIZED GROWTH|PLASMA MEMBRANE Mucin family member that functions as an osmosensor in the Sho1p-mediated HOG pathway with Msb2p; proposed to be a negative regulator of filamentous growth; mutant displays defects in beta-1,3 glucan synthesis and bud site selection (1->3)-beta-D-glucan biosynthetic process|fungal-type cell wall organization|osmosensory signaling pathway via Sho1 osmosensor|hyperosmotic response|cellular bud site selection osmosensor activity site of polarized growth|plasma membrane
YCR028C YCR028C FEN2 hom Verified 1.40739657786376 0.079654912700659 no 475 0.105106735485602 354 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION PLASMA MEMBRANE Plasma membrane H+-pantothenate symporter; confers sensitivity to the antifungal agent fenpropimorph; relocalizes from vacuole to cytoplasm upon DNA replication stress pantothenate transmembrane transport|endocytosis pantothenate transmembrane transporter activity integral to membrane|plasma membrane
YLR382C YLR382C NAM2 hom Verified 1.40512388594198 0.0799922212316612 no 476 0.0971740996204797 361 NA FT KETONE METABOLISM|RNA PROCESSING|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial leucyl-tRNA synthetase, also has a direct role in splicing of several mitochondrial group I introns; indirectly required for mitochondrial genome maintenance Group I intron splicing|leucyl-tRNA aminoacylation|mitochondrial translation mRNA binding|leucine-tRNA ligase activity mitochondrion
YPL236C YPL236C ENV7 hom Verified 1.40497663963318 0.0800141124398112 no 477 0.0601998332720735 305 NA FT PROTEIN PHOSPHORYLATION|VACUOLAR PROTEIN PROCESSING Vacuolar membrane protein kinase; negatively regulates membrane fusion; associates with vacuolar membrane through palmitoylation of one or more cysteines in consensus sequence; vacuolar membrane association is essential to its kinase activity; mutant shows defect in CPY processing; ortholog of human serine/threonine kinase 16 (STK16) vacuolar protein processing protein serine/threonine kinase activity fungal-type vacuole membrane
YPR099C_d YPR099C YPR099C hom Dubious 1.40099849606736 0.0806072614185114 no 478 0.0871025933011883 357 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene MRPL51/YPR100W Unknown Unknown Unknown
YFL049W YFL049W SWP82 hom Verified 1.39999916825015 0.0807567837696402 no 479 0.0686923153465595 290 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION NUCLEUS RSC COMPLEX Member of the SWI/SNF chromatin remodeling complex; has an as yet unidentified role in the complex; has identifiable counterparts in closely related yeast species; abundantly expressed in many growth conditions; paralog of Npl6p; relocates to the cytosol under hypoxic conditions positive regulation of transcription from RNA polymerase II promoter molecular_function SWI/SNF complex|nucleus
YMR084W_p YMR084W YMR084W hom Uncharacterized 1.39859870582472 0.0809666773311844 no 480 0.0857526809640675 378 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Putative protein of unknown function; YMR084W and adjacent ORF YMR085W are merged in related strains, and together are paralogous to glutamine-fructose-6-phosphate amidotransferase GFA1 biological_process molecular_function cellular_component
YML016C YML016C PPZ1 hom Verified 1.39742567528584 0.0811428013434772 no 481 0.0986883543294985 332 NA FT PROTEIN LOCALIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS NUCLEUS|PLASMA MEMBRANE Serine/threonine protein phosphatase Z, isoform of Ppz2p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance cellular sodium ion homeostasis|cellular protein localization|protein dephosphorylation protein serine/threonine phosphatase activity extrinsic to plasma membrane|nucleus|cytoplasm
YBR203W YBR203W COS111 hom Verified 1.39649741066007 0.081282379900271 no 482 0.111267123453584 399 NA FT SIGNALING MITOCHONDRION Protein required for resistance to the antifungal drug ciclopirox olamine; not related to the subtelomerically-encoded COS family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies signal transduction molecular_function mitochondrion
YNR020C YNR020C ATP23 hom Verified 1.3946542441689 0.0815600645028503 no 483 0.100147001680184 354 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Putative metalloprotease of the mitochondrial inner membrane, required for processing of Atp6p; has an additional role in assembly of the F0 sector of the F1F0 ATP synthase complex; substrate of the Mia40p-Erv1p disulfide relay system, and folding is assisted by Mia40p protein processing|mitochondrial proton-transporting ATP synthase complex assembly metalloendopeptidase activity mitochondrial inner membrane|mitochondrial intermembrane space
YIL041W YIL041W GVP36 hom Verified 1.39382944319977 0.0816845573724409 no 484 0.0978833700051309 333 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION ENDOMEMBRANE SYSTEM|GOLGI APPARATUS BAR domain-containing protein that localizes to both early and late Golgi vesicles; required for adaptation to varying nutrient concentrations, fluid-phase endocytosis, polarization of the actin cytoskeleton, and vacuole biogenesis vacuole organization|endocytosis|establishment or maintenance of actin cytoskeleton polarity molecular_function integral to Golgi membrane|cytoplasm
YNL329C YNL329C PEX6 hom Verified 1.39046805852316 0.0821933960927491 no 485 0.0903979772548641 377 NA FT PROTEIN LOCALIZATION|SIGNALING|PEROXISOME ORGANIZATION AAA-peroxin that heterodimerizes with AAA-peroxin Pex1p and participates in the recycling of peroxisomal signal receptor Pex5p from the peroxisomal membrane to the cystosol protein import into peroxisome matrix, receptor recycling|replicative cell aging ATPase activity|protein heterodimerization activity cytosol|peroxisome
YNL242W YNL242W ATG2 hom Verified 1.389956100967 0.0822711041063444 no 486 0.0743816036581964 287 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS|PEROXISOME ORGANIZATION Peripheral membrane protein required for autophagic vesicle formation; also required for vesicle formation during pexophagy and the cytoplasm-to-vaucole targeting (Cvt) pathway; involved in Atg9p cycling between the phagophore assembly site and mitochondria; forms cytoplasmic foci upon DNA replication stress mitochondrion degradation|piecemeal microautophagy of nucleus|peroxisome degradation|CVT pathway|autophagic vacuole assembly molecular_function pre-autophagosomal structure|cytoplasm|extrinsic to membrane
YBR162C YBR162C TOS1 hom Verified 1.38971441563737 0.0823078077868282 no 487 0.0773172140863659 320 NA Covalently-bound cell wall protein of unknown function; identified as a cell cycle regulated SBF target gene; deletion mutants are highly resistant to treatment with beta-1,3-glucanase; has sequence similarity to YJL171C biological_process molecular_function fungal-type cell wall|fungal-type vacuole
YCR081W YCR081W SRB8 hom Verified 1.388738511783 0.0824561394140653 no 488 0.0963700194053546 414 NA FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS NUCLEUS Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; involved in glucose repression negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription by galactose|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II transcription coactivator activity mediator complex
YOR104W YOR104W PIN2 hom Verified 1.38641891738625 0.0828095116344438 no 489 0.0909089755593313 375 NA Protein that induces appearance of [PIN+] prion when overproduced; predicted to be palmitoylated biological_process molecular_function cellular_component
YOR002W YOR002W ALG6 hom Verified 1.38557810375635 0.0829378840567107 no 490 0.12742370155025 514 NA FT LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Alpha 1,3 glucosyltransferase, involved in transfer of oligosaccharides from dolichyl pyrophosphate to asparagine residues of proteins during N-linked protein glycosylation; mutations in human ortholog are associated with disease oligosaccharide-lipid intermediate biosynthetic process|protein glycosylation|aerobic respiration transferase activity, transferring hexosyl groups|dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity integral to membrane|endoplasmic reticulum
YNL009W YNL009W IDP3 hom Verified 1.38454331026403 0.0830960780504214 no 491 0.0800526917474794 311 NA FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION Peroxisomal NADP-dependent isocitrate dehydrogenase; catalyzes oxidation of isocitrate to alpha-ketoglutarate with the formation of NADP(H+), required for growth on unsaturated fatty acids; IDP3 has a paralog, IDP2, that arose from the whole genome duplication NADPH regeneration|fatty acid beta-oxidation|isocitrate metabolic process isocitrate dehydrogenase (NADP+) activity mitochondrion|peroxisome|cytoplasm
YGL240W YGL240W DOC1 hom Verified 1.38244773231915 0.0834171343090569 no 492 0.0917305882384104 388 NA FT CELL CYCLE|CHROMATIN ORGANIZATION|CELL DIVISION|PROTEOLYSIS NUCLEUS|MITOCHONDRION UBIQUITIN LIGASE COMPLEX Processivity factor required for the ubiquitination activity of the anaphase promoting complex (APC), mediates the activity of the APC by contributing to substrate recognition; involved in cyclin proteolysis; contains a conserved DOC1 homology domain activation of mitotic anaphase-promoting complex activity|chromatin assembly|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cyclin catabolic process enzyme regulator activity|mitotic anaphase-promoting complex activity mitochondrion|anaphase-promoting complex
YDR518W YDR518W EUG1 hom Verified 1.38070551330896 0.083684762714712 no 493 0.0758854821908175 341 NA FT ENDOPLASMIC RETICULUM Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER protein folding protein disulfide isomerase activity|protein disulfide oxidoreductase activity endoplasmic reticulum
YHR136C YHR136C SPL2 hom Verified 1.37812296304244 0.0840826634488754 no 494 0.0914078384588981 361 NA Protein with similarity to cyclin-dependent kinase inhibitors; downregulates low-affinity phosphate transport during phosphate limitation; overproduction suppresses a plc1 null mutation; GFP-fusion protein localizes to the cytoplasm response to temperature stimulus enzyme inhibitor activity cytoplasm
YCR075C YCR075C ERS1 hom Verified 1.37794491922582 0.0841101474038054 no 495 0.0727866688894081 339 NA Protein with similarity to human cystinosin, which is a H(+)-driven transporter involved in L-cystine export from lysosomes and implicated in the disease cystinosis; contains seven transmembrane domains L-cystine transport|transmembrane transport L-cystine transmembrane transporter activity endosome|integral to membrane|fungal-type vacuole
YNR051C YNR051C BRE5 hom Verified 1.37577257669569 0.084446027086382 no 496 0.085344254344319 397 NA FT VESICLE-MEDIATED TRANSPORT Ubiquitin protease cofactor, forms deubiquitination complex with Ubp3p that coregulates anterograde and retrograde transport between the endoplasmic reticulum and Golgi compartments; null is sensitive to brefeldin A protein deubiquitination|ribophagy|regulation of ER to Golgi vesicle-mediated transport|Unknown molecular_function cytoplasm
YOR190W YOR190W SPR1 hom Verified 1.37166057443145 0.0850845635835042 no 497 0.086818999595882 340 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM Sporulation-specific exo-1,3-beta-glucanase; contributes to ascospore thermoresistance ascospore formation glucan exo-1,3-beta-glucosidase activity fungal-type cell wall|ascospore wall
YNR028W YNR028W CPR8 hom Verified 1.37109141105715 0.0851732310410844 no 498 0.0697572531226848 272 NA Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; similarity to Cpr4p suggests a potential role in the secretory pathway biological_process peptidyl-prolyl cis-trans isomerase activity fungal-type vacuole
YGR045C_d YGR045C YGR045C hom Dubious 1.36652185999876 0.0858876122075874 no 499 0.0700138962419371 289 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YBR158W YBR158W AMN1 hom Verified 1.36316654657565 0.0864150139019846 no 500 0.0931126692951418 388 NA FT CELL CYCLE|CELL DIVISION NUCLEUS Protein required for daughter cell separation, multiple mitotic checkpoints, and chromosome stability; contains 12 degenerate leucine-rich repeat motifs; expression is induced by the Mitotic Exit Network (MEN) mitotic cell cycle checkpoint|negative regulation of exit from mitosis protein binding nucleus|cellular bud|cytoplasm
YPL140C YPL140C MKK2 hom Verified 1.361881864777 0.086617585168759 no 501 0.08543410390129 312 NA FT SIGNALING|PROTEIN PHOSPHORYLATION|PEROXISOME ORGANIZATION MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk1p; MKK2 has a paralog, MKK1, that arose from the whole genome duplication signal transduction|peroxisome degradation|protein phosphorylation MAP kinase kinase activity intracellular
YGL180W YGL180W ATG1 hom Verified 1.36099078449042 0.0867583008759343 no 502 0.0780638241543299 314 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|PROTEIN PHOSPHORYLATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS Protein ser/thr kinase required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; structurally required for phagophore assembly site formation; during autophagy forms a complex with Atg13p and Atg17p piecemeal microautophagy of nucleus|mitochondrion degradation|protein phosphorylation|CVT pathway|autophagic vacuole assembly protein serine/threonine kinase activity|protein kinase activity cytosol|pre-autophagosomal structure|Atg1p signaling complex
YPR139C YPR139C LOA1 hom Verified 1.35960843337042 0.0869769339929242 no 503 0.122465482116764 444 NA FT PROTEIN LOCALIZATION|VACUOLAR TRANSPORT ENDOPLASMIC RETICULUM Lysophosphatidic acid acyltransferase; involved in triacelglyceride homeostasis and lipid droplet formation; localized to lipid droplets and the ER; specificity for oleoyl-CoA lipid particle organization|cellular triglyceride homeostasis|protein targeting to vacuole lysophosphatidic acid acyltransferase activity endoplasmic reticulum|lipid particle|cytoplasm
YLR419W_p YLR419W YLR419W hom Uncharacterized 1.35873620558716 0.087115097443089 no 504 0.0815604866568952 309 NA FT MITOCHONDRION Putative helicase with limited sequence similarity to human Rb protein; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YLR419W is not an essential gene biological_process molecular_function mitochondrion|cytoplasm
YOL056W YOL056W GPM3 hom Verified 1.35683054822784 0.0874175293175414 no 505 0.0822055193944024 338 NA FT CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY Homolog of Gpm1p phosphoglycerate mutase, which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event biological_process phosphoglycerate mutase activity|molecular_function cytosol
YDR136C_d YDR136C VPS61 hom Dubious 1.35467612109868 0.0877603845209407 no 506 0.199509158840329 656 NA FF Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 4% of ORF overlaps the verified gene RGP1; deletion causes a vacuolar protein sorting defect Unknown Unknown Unknown
YDL130W-A YDL130W-A STF1 hom Verified 1.35426305704674 0.0878262339138762 no 507 0.101409111424907 432 NA FT NUCLEOTIDE METABOLISM MITOCHONDRION Protein involved in regulation of the mitochondrial F1F0-ATP synthase; Stf1p and Stf2p act as stabilizing factors that enhance inhibitory action of the Inh1p protein; protein abundance increases in response to DNA replication stress negative regulation of ATPase activity molecular_function mitochondrion|mitochondrial proton-transporting ATP synthase complex
YPL062W_d YPL062W YPL062W hom Dubious 1.35404772014661 0.0878605768666837 no 508 0.112198517817262 442 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPL062W is not an essential gene; homozygous diploid mutant shows a decrease in glycogen accumulation Unknown Unknown Unknown
YCR032W YCR032W BPH1 hom Verified 1.35373223894313 0.087910909394038 no 509 0.0893699946319621 388 NA FT PROTEIN LOCALIZATION|CELL WALL ORG/BIOGENESIS MITOCHONDRION Protein homologous to Chediak-Higashi syndrome and Beige proteins; both of which are implicated in disease syndromes in human and mouse, respectively, due to defective lysosomal trafficking; mutant phenotype and genetic interactions suggest a role in protein sorting intracellular protein transport|fungal-type cell wall organization|response to pH molecular_function cytosol|mitochondrion|extrinsic to membrane
YHR025W YHR025W THR1 hom Verified 1.35285022723271 0.0880517414722528 no 510 0.108089852134499 407 NA FF|FT KETONE METABOLISM|AMINO ACID METABOLISM Homoserine kinase, conserved protein required for threonine biosynthesis; expression is regulated by the GCN4-mediated general amino acid control pathway threonine biosynthetic process|methionine metabolic process|isoleucine metabolic process|homoserine metabolic process homoserine kinase activity cellular_component
YKR085C YKR085C MRPL20 hom Verified 1.35237208696498 0.0881281570933674 no 511 0.101496532625331 403 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YPR027C_p YPR027C YPR027C hom Uncharacterized 1.35164176581712 0.0882449712756494 no 512 0.109253426620656 444 NA Putative protein of unknown function biological_process molecular_function cellular_component
YPL084W YPL084W BRO1 hom Verified 1.35047256511233 0.088432224046084 no 513 0.0936532209996256 426 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEOLYSIS|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS Cytoplasmic class E vacuolar protein sorting (VPS) factor that coordinates deubiquitination in the multivesicular body (MVB) pathway by recruiting Doa4p to endosomes protein deubiquitination|vacuolar transport|protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|response to nutrient|ubiquitin-dependent protein catabolic process ubiquitin-specific protease activity endosome|cytoplasm
YKL129C YKL129C MYO3 hom Verified 1.34970400620437 0.0885554733925887 no 514 0.0527257426868079 218 NA FT VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS|CELL DIVISION CYTOSKELETON One of two type I myosins; localizes to actin cortical patches; deletion of MYO3 has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization bipolar cellular bud site selection|fungal-type cell wall organization|endocytosis|exocytosis|actin cortical patch localization|response to osmotic stress microfilament motor activity actin cortical patch
YPR200C YPR200C ARR2 hom Verified 1.34746954596818 0.0889145276326547 no 515 0.0747439435458456 314 NA Arsenate reductase required for arsenate resistance; converts arsenate to arsenite which can then be exported from cells by Arr3p response to arsenic-containing substance arsenate reductase activity cellular_component
YLR130C YLR130C ZRT2 hom Verified 1.34621656919383 0.089116341500815 no 516 0.0810865550920364 317 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE Low-affinity zinc transporter of the plasma membrane; transcription is induced under low-zinc conditions by the Zap1p transcription factor low-affinity zinc ion transport low-affinity zinc ion transmembrane transporter activity integral to membrane|plasma membrane
YLR414C YLR414C PUN1 hom Verified 1.34536909122959 0.0892530358161855 no 517 0.061760139594622 242 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL WALL ORG/BIOGENESIS PLASMA MEMBRANE Plasma membrane protein with a role in cell wall integrity; co-localizes with Sur7p in punctate membrane patches; null mutant displays decreased thermotolerance; transcription induced upon cell wall damage and metal ion stress fungal-type cell wall organization|protein oligomerization molecular_function integral to membrane|membrane raft|plasma membrane|cellular bud|cytoplasm
YGR122C-A_d YGR122C-A YGR122C-A hom Dubious 1.34083657011748 0.0899867599721164 no 518 0.0677555491991272 289 NA Dubious open reading frame unlikely to encode a functional protein, similar to YLR334C and YOL106W Unknown Unknown Unknown
YNL080C YNL080C EOS1 hom Verified 1.33789134791276 0.0904659289901233 no 519 0.106289005909004 387 NA FT CARBOHYDRATE METABOLISM|RESPONSE TO OXIDATIVE STRESS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Protein involved in N-glycosylation; deletion mutation confers sensitivity to exidative stress and shows synthetic lethality with mutations in the spindle checkpoint genes BUB3 and MAD1; YNL080C is not an essential gene cellular response to oxidative stress|protein N-linked glycosylation molecular_function integral to membrane|endoplasmic reticulum membrane
YMR306W YMR306W FKS3 hom Verified 1.33671699015487 0.0906575169416252 no 520 0.103058682256119 418 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM MITOCHONDRION|PLASMA MEMBRANE Protein involved in spore wall assembly, has similarity to 1,3-beta-D-glucan synthase catalytic subunits Fks1p and Gsc2p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies ascospore wall assembly 1,3-beta-D-glucan synthase activity mitochondrion|integral to membrane
YDR109C_p YDR109C YDR109C hom Uncharacterized 1.33357792626223 0.0911711105623686 no 521 0.0734056282376147 299 NA FT CARBOHYDRATE METABOLISM Putative kinase biological_process molecular_function cellular_component
YGR250C YGR250C YGR250C hom Verified 1.32965886003845 0.0918153477005514 no 522 0.0967725303523266 391 NA Putative RNA binding protein; localizes to stress granules induced by glucose deprivation; interacts with Rbg1p in a two-hybrid assay; protein abundance increases in response to DNA replication stress biological_process RNA binding cytoplasmic stress granule|cytoplasm
YDR204W YDR204W COQ4 hom Verified 1.32751202048521 0.0921696831430362 no 523 0.0805169033019446 360 NA FT KETONE METABOLISM|COFACTOR METABOLISM MITOCHONDRION Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex ubiquinone biosynthetic process molecular_function mitochondrial inner membrane
YDR374C_p YDR374C YDR374C hom Uncharacterized 1.32750513972306 0.0921708204366018 no 524 0.0685954316062976 241 NA Putative protein of unknown function biological_process molecular_function cellular_component
YDR169C-A_p YDR169C-A YDR169C-A hom Uncharacterized 1.32633215288797 0.092364850592307 no 525 0.104160354777946 387 NA Putative protein of unknown function; identified by fungal homology and RT-PCR biological_process molecular_function cellular_component
YAL046C YAL046C AIM1 hom Verified 1.32582686030746 0.092448526883231 no 526 0.101206266661456 388 NA Protein involved in mitochondrial function or organization; null mutant displays elevated frequency of mitochondrial genome loss biological_process molecular_function cellular_component
YPL241C YPL241C CIN2 hom Verified 1.32544302029047 0.0925121281455112 no 527 0.0935671756611429 441 NA FF|FT PROTEIN COMPLEX ORG/BIOGENESIS CYTOSKELETON GTPase-activating protein (GAP) for Cin4p; tubulin folding factor C involved in beta-tubulin (Tub2p) folding; mutants display increased chromosome loss and benomyl sensitivity; deletion complemented by human GAP, retinitis pigmentosa 2 protein folding|tubulin complex assembly|tubulin complex biogenesis GTPase activator activity cellular_component
YGR289C YGR289C MAL11 hom Verified 1.32271223362859 0.092965546818197 no 528 0.110274715255823 444 NA FT CARBOHYDRATE METABOLISM PLASMA MEMBRANE Inducible high-affinity maltose transporter (alpha-glucoside transporter); encoded in the MAL1 complex locus; broad substrate specificity that includes maltotriose; required for isomaltose utilization trehalose transport|maltose transport|disaccharide catabolic process trehalose transmembrane transporter activity|alpha-glucoside:hydrogen symporter activity|maltose:hydrogen symporter activity integral to membrane|plasma membrane
YKL043W YKL043W PHD1 hom Verified 1.3183613300454 0.0936913596543787 no 529 0.0718150847090463 271 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Transcriptional activator that enhances pseudohyphal growth; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; regulates expression of FLO11, an adhesin required for pseudohyphal filament formation; similar to StuA, an A. nidulans developmental regulator; potential Cdc28p substrate; PHD1 has a paralog, SOK2, that arose from the whole genome duplication pseudohyphal growth|positive regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity nucleus
YOR274W YOR274W MOD5 hom Verified 1.31645428737428 0.0940108058610543 no 530 0.101442309939805 395 NA FT RNA PROCESSING NUCLEUS|MITOCHONDRION Delta 2-isopentenyl pyrophosphate:tRNA isopentenyl transferase; required for biosynthesis of the modified base isopentenyladenosine in mitochondrial and cytoplasmic tRNAs; gene is nuclear and encodes two isozymic forms; converts to a prion form, and prion conversion contributes to azole antifungal resistance by upregulating ergosterol biosynthesis tRNA modification tRNA dimethylallyltransferase activity cytosol|mitochondrion|nucleolus|nucleus
YNL231C YNL231C PDR16 hom Verified 1.31510381798316 0.0942375068166525 no 531 0.112761652344461 446 NA FF|FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Phosphatidylinositol transfer protein (PITP); controlled by the multiple drug resistance regulator Pdr1p; localizes to lipid particles and microsomes; controls levels of various lipids, may regulate lipid synthesis; homologous to Pdr17p; protein abundance increases in response to DNA replication stress response to drug|sterol biosynthetic process|phospholipid biosynthetic process|phospholipid transport phosphatidylinositol transporter activity|phosphatidylcholine transporter activity cell periphery|lipid particle|plasma membrane|cytoplasm
YHR047C YHR047C AAP1 hom Verified 1.31504436089907 0.0942474970336408 no 532 0.0842713499119327 288 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|PROTEOLYSIS|GEN. OF PRECURSOR METABOLITES AND ENERGY NUCLEUS Arginine/alanine amino peptidase; overproduction stimulates glycogen accumulation; AAP1 has a paralog, APE2, that arose from the whole genome duplication glycogen metabolic process|proteolysis aminopeptidase activity nucleus|cytoplasm
YKL208W YKL208W CBT1 hom Verified 1.31446388622249 0.094345071754378 no 533 0.0930780299484357 370 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS MITOCHONDRION Protein involved in 5' end processing of mitochondrial COB, 15S_rRNA, and RPM1 transcripts; may also have a role in 3' end processing of the COB pre-mRNA; displays genetic interaction with cell cycle-regulated kinase Dbf2p cytochrome complex assembly|mRNA processing|mRNA stabilization molecular_function mitochondrion
YKL009W YKL009W MRT4 hom Verified 1.31286289673734 0.0946145756746069 no 534 0.105918589063408 408 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Protein involved in mRNA turnover and ribosome assembly, localizes to the nucleolus nuclear-transcribed mRNA catabolic process|ribosomal large subunit assembly|ribosomal large subunit biogenesis|rRNA processing LSU rRNA binding nucleoplasm|nucleolus|nucleus|preribosome, large subunit precursor
YPL114W_d YPL114W YPL114W hom Dubious 1.3111840496403 0.094897794926533 no 535 0.0894994970184008 372 NA Dubious open reading frame, unlikely to encode a functional protein; largely overlaps ORF YPL113C; diploid deletion in BY4743 strain background exhibits high budding index Unknown Unknown Unknown
YBR039W YBR039W ATP3 hom Verified 1.30839830716083 0.0953691232595884 no 536 0.117895118365008 462 NA FT ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS MITOCHONDRION Gamma subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis ATP synthesis coupled proton transport proton-transporting ATPase activity, rotational mechanism mitochondrion|integral to membrane|mitochondrial proton-transporting ATP synthase, central stalk
YBR189W YBR189W RPS9B hom Verified 1.3062025908516 0.0957418359986208 no 537 0.0996785938993625 356 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION NUCLEUS RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S9 and bacterial S4; RPS9B has a paralog, RPS9A, that arose from the whole genome duplication positive regulation of translational fidelity|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) structural constituent of ribosome small-subunit processome|cytosolic small ribosomal subunit|90S preribosome
YLR408C_p YLR408C BLS1 hom Uncharacterized 1.3050806862811 0.0959326872791931 no 538 0.0785885516018027 295 NA Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to the endosome; YLR408C is not an essential gene biological_process molecular_function endosome|BLOC-1 complex
YMR169C YMR169C ALD3 hom Verified 1.30434479588163 0.0960580241411404 no 539 0.0963330309092565 394 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS Cytoplasmic aldehyde dehydrogenase, involved in beta-alanine synthesis; uses NAD+ as the preferred coenzyme; very similar to Ald2p; expression is induced by stress and repressed by glucose beta-alanine biosynthetic process|polyamine catabolic process aldehyde dehydrogenase (NAD) activity cytoplasm
YNL115C_p YNL115C YNL115C hom Uncharacterized 1.30399611126705 0.0961174541331442 no 540 0.0837060383195241 362 NA Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL115C is not an essential gene biological_process molecular_function integral to membrane|fungal-type vacuole
YLR444C_d YLR444C YLR444C hom Dubious 1.30391838695149 0.0961307051906789 no 541 0.0824033682307126 367 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YCR063W YCR063W BUD31 hom Verified 1.30191312809744 0.0964730420714529 no 542 0.0795662233444386 371 NA FT CELL CYCLE|RNA PROCESSING|CELL DIVISION NUCLEUS Component of the SF3b subcomplex of the U2 snRNP; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; facilitates passage through G1/S Start, but is not required for G2/M transition or exit from mitosis RNA splicing|mRNA splicing, via spliceosome|cellular bud site selection molecular_function U2 snRNP|nucleus
YDL044C YDL044C MTF2 hom Verified 1.30186781363211 0.0964807884726382 no 543 0.111566620426857 445 NA FT RNA PROCESSING|TRANSLATION MITOCHONDRION Mitochondrial matrix protein that interacts with an N-terminal region of mitochondrial RNA polymerase (Rpo41p) and couples RNA processing and translation to transcription cytoplasmic translation|mRNA processing RNA binding mitochondrion
YPL118W YPL118W MRP51 hom Verified 1.29795529476246 0.0971513487113256 no 544 0.115207763912688 450 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the small subunit; MRP51 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequences mitochondrial translational initiation|mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial small ribosomal subunit
YPL229W_p YPL229W YPL229W hom Uncharacterized 1.29428815362603 0.0977829534224607 no 545 0.0982265095424073 428 NA Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; not an essential gene; YPL229W has a paralog, YMR181C, that arose from the whole genome duplication biological_process molecular_function cytoplasm
YJR048W YJR048W CYC1 hom Verified 1.29254920349684 0.098083508928332 no 546 0.0707130239940339 320 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Cytochrome c, isoform 1; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration; CYC1 has a paralog, CYC7, that arose from the whole genome duplication mitochondrial electron transport, cytochrome c to oxygen|mitochondrial electron transport, ubiquinol to cytochrome c electron carrier activity mitochondrion|mitochondrial intermembrane space
YDR127W YDR127W ARO1 hom Verified 1.28990536985397 0.0985417580584565 no 547 0.225480880707206 855 NA FF|FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS Pentafunctional arom protein, catalyzes steps 2 through 6 in the biosynthesis of chorismate, which is a precursor to aromatic amino acids aromatic amino acid family biosynthetic process shikimate kinase activity|shikimate 3-dehydrogenase (NADP+) activity|3-phosphoshikimate 1-carboxyvinyltransferase activity|3-dehydroquinate dehydratase activity|3-dehydroquinate synthase activity cytoplasm
YOR091W YOR091W TMA46 hom Verified 1.2882226852043 0.0988342287067802 no 548 0.107778593434178 407 NA FT TRANSLATION Protein of unknown function that associates with translating ribosomes; interacts with GTPase Rbg1p cytoplasmic translation molecular_function polysomal ribosome|ribosome|cytoplasm
YPL102C_d YPL102C YPL102C hom Dubious 1.28790265591834 0.0988899254267741 no 549 0.0990061904647672 381 NA Dubious open reading frame, not conserved in closely related Saccharomyces species; deletion mutation enhances replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene ELP4 Unknown Unknown Unknown
YKR041W YKR041W YKR041W hom Verified 1.28585968033286 0.0992460186839369 no 550 0.0790323478045957 314 NA FT NUCLEUS|CYTOSKELETON Protein of unknown function; localizes to the mitotic spindle; overexpression of YKR041W affects endocytic protein trafficking biological_process molecular_function nucleus|mitotic spindle|cytoplasm
YDR359C YDR359C EAF1 hom Verified 1.28539265925046 0.0993275525566069 no 551 0.119749834210972 480 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE NUCLEUS HISTONE ACETYLTRANSFERASE Component of the NuA4 histone acetyltransferase complex; acts as a platform for assembly of NuA4 subunits into the native complex; required for initiation of pre-meiotic DNA replication, likely due to its requirement for expression of IME1 DNA repair|cellular protein complex assembly|chromatin modification molecular_function histone acetyltransferase complex|NuA4 histone acetyltransferase complex
YKL106C-A_p YKL106C-A YKL106C-A hom Uncharacterized 1.28262162829528 0.0998123345140779 no 552 0.0696347999849787 269 NA Putative protein of unknown function; identified by homology to uncharacterized proteins in other fungi biological_process molecular_function cellular_component
YLR164W YLR164W SHH4 hom Verified 1.28172317193036 0.0999698866771174 no 553 0.074389304367923 279 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION Mitochondrial inner membrane protein of unknown function; similar to Tim18p and Sdh4p; a fraction copurifies with Sdh3p, but Shh4p is neither a stoichiometric subunit of succinate dehydrogenase nor of the TIM22 translocase; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner biological_process molecular_function mitochondrion|mitochondrial inner membrane
YOR156C YOR156C NFI1 hom Verified 1.28157963530931 0.0999950738917209 no 554 0.0952881938812604 408 NA FT CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME RSC COMPLEX SUMO E3 ligase, catalyzes the covalent attachment of SUMO (Smt3p) to proteins; primary E3 ligase for Sir4p; sumoylates Yku70p/Yku80p and Sir4p in vivo to promote chromatin anchoring; promotes telomere anchoring to the nuclear envelope; involved in maintenance of proper telomere length protein sumoylation|chromosome segregation|chromosome condensation SUMO ligase activity nuclear chromatin|nucleus|cytoplasm
YFL001W YFL001W DEG1 hom Verified 1.27761974949443 0.100691766760338 no 555 0.129543644041194 416 NA FT RNA PROCESSING NUCLEUS tRNA:pseudouridine synthase, introduces pseudouridines at position 38 or 39 in tRNA, important for maintenance of translation efficiency and normal cell growth, localizes to both the nucleus and cytoplasm; non-essential for viability tRNA pseudouridine synthesis pseudouridine synthase activity nucleus|cytoplasm
YDL214C YDL214C PRR2 hom Verified 1.27614149764517 0.100952752285453 no 556 0.0926477095591539 364 NA FT TRANSCRIPTION FROM RNA POL II|PROTEIN PHOSPHORYLATION NUCLEUS Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor; mutant has increased aneuploidy tolerance negative regulation of transcription from RNA polymerase II promoter by pheromones|negative regulation of conjugation with cellular fusion|protein phosphorylation protein kinase activity|receptor signaling protein serine/threonine kinase activity nucleus
YLR120C YLR120C YPS1 hom Verified 1.27230839616384 0.101631783285291 no 557 0.121085299392328 404 NA FT CELL WALL ORG/BIOGENESIS|PROTEOLYSIS PLASMA MEMBRANE Aspartic protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor fungal-type cell wall organization|protein processing aspartic-type endopeptidase activity fungal-type cell wall
YCR069W YCR069W CPR4 hom Verified 1.27124845974849 0.101820135842431 no 558 0.0921961792129542 364 NA Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; has a potential role in the secretory pathway biological_process peptidyl-prolyl cis-trans isomerase activity membrane
YDR245W YDR245W MNN10 hom Verified 1.2698584399479 0.102067529729966 no 559 0.110874711853657 430 NA FT CELL WALL ORG/BIOGENESIS|CELL DIVISION|CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS Subunit of a Golgi mannosyltransferase complex also containing Anp1p, Mnn9p, Mnn11p, and Hoc1p that mediates elongation of the polysaccharide mannan backbone; membrane protein of the mannosyltransferase family N-glycan processing|cell wall mannoprotein biosynthetic process|substituted mannan metabolic process|barrier septum assembly alpha-1,6-mannosyltransferase activity alpha-1,6-mannosyltransferase complex
YPL148C YPL148C PPT2 hom Verified 1.26908585378505 0.102205222549189 no 560 0.158618987707356 572 NA FF|FT KETONE METABOLISM|LIPID METABOLISM MITOCHONDRION Phosphopantetheine:protein transferase (PPTase), activates mitochondrial acyl carrier protein (Acp1p) by phosphopantetheinylation protein-cofactor linkage holo-[acyl-carrier-protein] synthase activity mitochondrion
YBR282W YBR282W MRPL27 hom Verified 1.26656609937327 0.10265524028466 no 561 0.101062340012753 428 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit; homolog of human Bcl-2 interacting protein BMRP mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YGL236C YGL236C MTO1 hom Verified 1.26356602859206 0.103192916624298 no 562 0.119524537224692 431 NA FT RNA PROCESSING|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial protein, forms a heterodimer complex with Mss1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; required for respiration in paromomycin-resistant 15S rRNA mutants mitochondrial tRNA wobble uridine modification molecular_function mitochondrion
YPL267W YPL267W ACM1 hom Verified 1.2622746493309 0.103424987712114 no 563 0.115177340575457 453 NA FT CELL CYCLE|CELL DIVISION NUCLEUS Pseudosubstrate inhibitor of the anaphase-promoting complex/cyclosome (APC/C), that suppresses APC/C [Cdh1]-mediated proteolysis of mitotic cyclins; associates with Cdh1p, Bmh1p and Bmh2p; cell cycle regulated protein negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle ubiquitin-protein ligase inhibitor activity nucleus|cytoplasm
YAL018C_p YAL018C YAL018C hom Uncharacterized 1.26049906620359 0.103744692269881 no 564 0.110222555907909 383 NA Putative protein of unknown function biological_process molecular_function integral to membrane
YML131W YML131W YML131W hom Verified 1.25767178423111 0.104255240292581 no 565 0.0809676773577611 302 NA FT OXIDATION-REDUCTION PROCESS Protein of unknown function; similar to medium chain dehydrogenase/reductases; expression induced by stresses including osmotic shock, DNA damaging agents, and other chemicals; GFP-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress biological_process molecular_function cytoplasm
YLR171W_d YLR171W YLR171W hom Dubious 1.25734156268929 0.104314989965737 no 566 0.113250899236698 483 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YPL123C YPL123C RNY1 hom Verified 1.25605805442278 0.104547461257946 no 567 0.0816562815390664 325 NA Vacuolar RNase of the T(2) family, relocalizes to the cytosol where it cleaves tRNAs upon oxidative or stationary phase stress; promotes apoptosis under stress conditions and this function is independent of its catalytic activity cell morphogenesis|RNA catabolic process|apoptotic process endoribonuclease activity cytosol|extracellular region|vacuole
YCL010C YCL010C SGF29 hom Verified 1.25448642149286 0.104832629055663 no 568 0.0916415523308602 381 NA FT PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION NUCLEUS HISTONE ACETYLTRANSFERASE Component of the HAT/Core module of the SAGA, SLIK, and ADA complexes; HAT/Core module also contains Gcn5p, Ngg1p, and Ada2p; binds methylated histone H3K4; involved in transcriptional regulation through SAGA and TBP recruitment to target promoters and H3 acetylation histone H3-K14 acetylation|cellular protein complex localization|histone H3-K18 acetylation|cellular protein localization|histone H3-K9 acetylation|positive regulation of transcription from RNA polymerase II promoter methylated histone residue binding|RNA polymerase II transcription factor recruiting transcription factor activity Ada2/Gcn5/Ada3 transcription activator complex|SAGA complex
YDR003W-A_p YDR003W-A YDR003W-A hom Uncharacterized 1.25351611382235 0.105008969259734 no 569 0.122430153990763 431 NA Putative protein of unknown function; identified by expression profiling and mass spectrometry biological_process molecular_function cellular_component
YGL164C YGL164C YRB30 hom Verified 1.25252151249529 0.10518994724541 no 570 0.101185704073492 399 NA FT PROTEIN LOCALIZATION NUCLEUS RanGTP-binding protein, inhibits RanGAP1 (Rna1p)-mediated GTP hydrolysis of RanGTP (Gsp1p); shares similarity to proteins in other fungi but not in higher eukaryotes biological_process GTPase regulator activity nucleus|cytoplasm
YPL112C YPL112C PEX25 hom Verified 1.25184772794503 0.105312677478206 no 571 0.102821561243934 386 NA FT PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION Peripheral peroxisomal membrane peroxin required for the regulation of peroxisome size and maintenance, recruits GTPase Rho1p to peroxisomes, induced by oleate, interacts with homologous protein Pex27p protein import into peroxisome matrix|peroxisome organization molecular_function peroxisomal membrane
YER176W YER176W ECM32 hom Verified 1.25097693067127 0.105471447106724 no 572 0.0922530892970374 369 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION DNA dependent ATPase/DNA helicase belonging to the Dna2p- and Nam7p-like family of helicases that is involved in modulating translation termination; interacts with the translation termination factors, localized to polysomes regulation of translational termination RNA helicase activity|DNA helicase activity polysome
YMR271C YMR271C URA10 hom Verified 1.25091491198939 0.105482761371261 no 573 0.0876367476810047 368 NA FT NUCLEOTIDE METABOLISM Minor orotate phosphoribosyltransferase (OPRTase) isozyme; catalyzes the fifth enzymatic step in the de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; URA10 has a paralog, URA5, that arose from the whole genome duplication 'de novo' pyrimidine nucleobase biosynthetic process|pyrimidine ribonucleoside biosynthetic process orotate phosphoribosyltransferase activity cytoplasm
YGR051C_d YGR051C YGR051C hom Dubious 1.25061984628811 0.105536603164858 no 574 0.093074555705165 378 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YGR051C is not an essential gene Unknown Unknown Unknown
YLR041W_d YLR041W YLR041W hom Dubious 1.24442402952743 0.106671771794355 no 575 0.0858734648170154 362 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YLR040C Unknown Unknown Unknown
YGL163C YGL163C RAD54 hom Verified 1.24336593457758 0.106866508707097 no 576 0.164745879071675 552 NA FF|FT CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE NUCLEUS DNA-dependent ATPase that stimulates strand exchange; modifies the topology of double-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; member of the SWI/SNF family; forms nuclear foci upon DNA replication stress positive regulation of endodeoxyribonuclease activity|DNA geometric change|heteroduplex formation|telomere maintenance via recombination|double-strand break repair via synthesis-dependent strand annealing|chromatin remodeling|double-strand break repair via single-strand annealing DNA-dependent ATPase activity|DNA translocase activity nucleus
YJL209W YJL209W CBP1 hom Verified 1.23679800515338 0.108081041431849 no 577 0.102713421597422 408 NA FT RNA PROCESSING|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Mitochondrial protein, regulator of COB mRNA stability and translation; interacts with the 5'-untranslated region of the COB mRNA; found in a complex at the inner membrane along with Pet309p; localizes to mitochondrial foci upon DNA replication stress mitochondrial mRNA catabolic process|aerobic respiration mRNA binding mitochondrion|extrinsic to mitochondrial inner membrane
YDL009C_p YDL009C YDL009C hom Uncharacterized 1.23510601862043 0.108395524872799 no 578 0.105333958451144 429 NA Protein of unknown function; mRNA identified as translated by ribosome profiling data; partially overlaps the verified ORF YDL010W; YDL009C is not an essential gene biological_process molecular_function cellular_component
YJL044C YJL044C GYP6 hom Verified 1.23491760813081 0.108430584751368 no 579 0.110584965034886 399 NA FT PROTEIN LOCALIZATION|SIGNALING|NUCLEOTIDE METABOLISM GTPase-activating protein (GAP) for the yeast Rab family member, Ypt6p; involved in vesicle mediated protein transport intracellular protein transport GTPase activator activity endosome|clathrin-coated vesicle
YDR492W YDR492W IZH1 hom Verified 1.23198887043733 0.108976620798656 no 580 0.104403756802475 446 NA FT LIPID METABOLISM|ION HOMEOSTASIS|ION HOMEOSTASIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family; transcription is regulated directly by Zap1p, expression induced by zinc deficiency and fatty acids; deletion increases sensitivity to elevated zinc response to zinc ion|cellular zinc ion homeostasis|cellular lipid metabolic process metal ion binding integral to membrane|endoplasmic reticulum|membrane
YDR363W YDR363W ESC2 hom Verified 1.23053952112925 0.109247568477079 no 581 0.127476198260087 465 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION|GENE SILENCING NUCLEUS Sumo-like domain protein; prevents accumulation of toxic intermediates during replication-associated recombinational repair; roles in silencing, lifespan, chromatid cohesion and the intra-S-phase DNA damage checkpoint; RENi family member intra-S DNA damage checkpoint|double-strand break repair via homologous recombination|chromatin silencing at silent mating-type cassette|mitotic sister chromatid cohesion molecular_function nucleus
YJR051W YJR051W OSM1 hom Verified 1.22978881727899 0.109388098446388 no 582 0.0996485518076789 387 NA FT OXIDATION-REDUCTION PROCESS MITOCHONDRION Fumarate reductase, catalyzes the reduction of fumarate to succinate; required for the reoxidation of intracellular NADH under anaerobic conditions; mutations cause osmotic sensitivity; OSM1 has a paralog, FRD1, that arose from the whole genome duplication cellular response to anoxia fumarate reductase (NADH) activity mitochondrion
YMR101C YMR101C SRT1 hom Verified 1.22812725728412 0.109699600145494 no 583 0.0872107215000688 306 NA FT CARBOHYDRATE METABOLISM Cis-prenyltransferase involved in synthesis of long-chain dolichols (19-22 isoprene units; as opposed to Rer2p which synthesizes shorter-chain dolichols); localizes to lipid bodies; transcription is induced during stationary phase protein glycosylation dehydrodolichyl diphosphate synthase activity|prenyltransferase activity lipid particle
YLR012C_p YLR012C YLR012C hom Uncharacterized 1.22789527375933 0.109743141971308 no 584 0.143380407915732 520 NA Putative protein of unknown function; YLR012C is not an essential gene biological_process molecular_function cellular_component
YMR066W YMR066W SOV1 hom Verified 1.22512550690915 0.110263968061092 no 585 0.129989519388057 482 NA FT MITOCHONDRION Mitochondrial protein of unknown function biological_process molecular_function mitochondrion
YBR113W_d YBR113W YBR113W hom Dubious 1.22297016501551 0.110670482582829 no 586 0.0825316166213069 299 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CYC8 Unknown Unknown Unknown
YBL094C_d YBL094C YBL094C hom Dubious 1.22263196227858 0.110734367658569 no 587 0.0919539748647708 323 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized ORF YBL095W Unknown Unknown Unknown
YDR350C YDR350C ATP22 hom Verified 1.22167893536498 0.110914532579555 no 588 0.118557387323615 435 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Specific translational activator for the mitochondrial ATP6 mRNA, encoding a subunit of F1F0 ATP synthase; localized to the mitochondrial inner membrane proton-transporting ATP synthase complex biogenesis|positive regulation of mitochondrial translation translation regulator activity mitochondrial inner membrane
YPL170W YPL170W DAP1 hom Verified 1.21774898179511 0.111659688585773 no 589 0.134665599394275 530 NA FT LIPID METABOLISM Heme-binding protein involved in regulation of cytochrome P450 protein Erg11p; damage response protein, related to mammalian membrane progesterone receptors; mutations lead to defects in telomeres, mitochondria, and sterol synthesis regulation of ergosterol biosynthetic process heme binding endosome|membrane
YOL096C YOL096C COQ3 hom Verified 1.21769308317171 0.111670313259051 no 590 0.109745293422179 464 NA FT KETONE METABOLISM|COFACTOR METABOLISM MITOCHONDRION O-methyltransferase, catalyzes two different O-methylation steps in ubiquinone (Coenzyme Q) biosynthesis; component of a mitochondrial ubiquinone-synthesizing complex; phosphoprotein ubiquinone biosynthetic process hexaprenyldihydroxybenzoate methyltransferase activity mitochondrion|mitochondrial inner membrane|extrinsic to membrane
YLR261C_d YLR261C VPS63 hom Dubious 1.21769289316941 0.111670349374096 no 591 0.217026773389278 704 NA FF Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene YPT6; deletion causes a vacuolar protein sorting defect Unknown Unknown Unknown
YIL064W YIL064W SEE1 hom Verified 1.21384709177001 0.112403059902747 no 592 0.124578689143705 465 NA FT VESICLE-MEDIATED TRANSPORT Probable lysine methyltransferase involved in the dimethylation of eEF1A (Tef1p/Tef2p); sequence similarity to S-adenosylmethionine-dependent methyltransferases of the seven beta-strand family; role in vesicular transport vesicle-mediated transport|peptidyl-lysine dimethylation protein-lysine N-methyltransferase activity cytoplasm
YIR023W YIR023W DAL81 hom Verified 1.21277848662023 0.112607261352575 no 593 0.263891857211498 947 NA FF|FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM|RESPONSE TO NUTRIENT LEVELS NUCLEUS Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism nitrogen utilization|nitrogen catabolite activation of transcription from RNA polymerase II promoter|gamma-aminobutyric acid catabolic process|urea catabolic process RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly|RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II transcription factor recruiting transcription factor activity nucleus
YJR077C YJR077C MIR1 hom Verified 1.21149723483404 0.112852446894811 no 594 0.108025548535684 421 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; functionally redundant with Pic2p but more abundant than Pic2p under normal conditions; phosphorylated phosphate ion transmembrane transport inorganic phosphate transmembrane transporter activity mitochondrion|integral to membrane|integral to mitochondrial inner membrane
YIL156W YIL156W UBP7 hom Verified 1.20945838873536 0.11324339411724 no 595 0.116283354862366 387 NA FT PROTEOLYSIS Ubiquitin-specific protease that cleaves ubiquitin-protein fusions protein deubiquitination ubiquitin-specific protease activity cytoplasm
YKR095W YKR095W MLP1 hom Verified 1.20649122731914 0.113814069812757 no 596 0.103711735527546 351 NA FT PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|RNA LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS|CYTOSKELETON Myosin-like protein associated with the nuclear envelope, connects the nuclear pore complex with the nuclear interior; involved with Tel1p in telomere length control; involved with Pml1p and Pml39p in nuclear retention of unspliced mRNAs protein localization to nuclear pore|poly(A)+ mRNA export from nucleus|protein import into nucleus|transcriptional activation by promoter-terminator looping|nuclear retention of unspliced pre-mRNA at the site of transcription|telomere tethering at nuclear periphery ribonucleoprotein complex binding nucleoplasm|nuclear envelope|integral to membrane|ribonucleoprotein complex|spindle pole body
YDR425W YDR425W SNX41 hom Verified 1.20649026436792 0.113814255349745 no 597 0.0935751620561018 351 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT Sorting nexin, involved in the retrieval of late-Golgi SNAREs from the post-Golgi endosome to the trans-Golgi network; interacts with Snx4p retrograde transport, endosome to Golgi phosphatidylinositol binding|phosphatidylinositol-3-phosphate binding endosome
YBR056W-A_p YBR056W-A YBR056W-A hom Uncharacterized 1.20568488860249 0.11396950691701 no 598 0.142282957334223 490 NA Protein of unknown function; mRNA identified as translated by ribosome profiling data; partially overlaps the dubious ORF YBR056C-B biological_process molecular_function cellular_component
YJL178C YJL178C ATG27 hom Verified 1.205448042523 0.114015192222026 no 599 0.11555337876057 421 NA FT PROTEIN LOCALIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS|PEROXISOME ORGANIZATION ENDOMEMBRANE SYSTEM|MITOCHONDRION|GOLGI APPARATUS Type I membrane protein involved in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; may be involved in membrane delivery to the phagophore assembly site vesicle organization|peroxisome degradation|protein localization to pre-autophagosomal structure|CVT pathway|autophagic vacuole assembly phosphatidylinositol-3-phosphate binding trans-Golgi network|mitochondrion|pre-autophagosomal structure|membrane
YJR075W YJR075W HOC1 hom Verified 1.20433719505963 0.114229637986931 no 600 0.100543393543943 407 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM GOLGI APPARATUS Alpha-1,6-mannosyltransferase involved in cell wall mannan biosynthesis; subunit of a Golgi-localized complex that also contains Anp1p, Mnn9p, Mnn11p, and Mnn10p; identified as a suppressor of a cell lysis sensitive pkc1-371 allele cell wall mannoprotein biosynthetic process|substituted mannan metabolic process alpha-1,6-mannosyltransferase activity|transferase activity, transferring glycosyl groups alpha-1,6-mannosyltransferase complex
YKL065C YKL065C YET1 hom Verified 1.20430158193554 0.114236517742312 no 601 0.0913115660189981 341 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Endoplasmic reticulum transmembrane protein; may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein biological_process molecular_function ribosome|integral to membrane|endoplasmic reticulum|endoplasmic reticulum membrane
YOL132W YOL132W GAS4 hom Verified 1.19658820609489 0.115733549818796 no 602 0.103798728583906 394 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM PLASMA MEMBRANE 1,3-beta-glucanosyltransferase, involved with Gas2p in spore wall assembly; has similarity to Gas1p; localizes to the cell wall ascospore wall assembly 1,3-beta-glucanosyltransferase activity fungal-type cell wall|integral to membrane
YMR175W YMR175W SIP18 hom Verified 1.19445860052926 0.11614931286815 no 603 0.0941390046298272 365 NA Phospholipid-binding hydrophilin; essential to overcome desiccation-rehydration process; expression is induced by osmotic stress cellular response to water deprivation phospholipid binding cytoplasm
YGL202W YGL202W ARO8 hom Verified 1.19137139636336 0.116753908403391 no 604 0.0953791393772601 365 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Aromatic aminotransferase I, expression is regulated by general control of amino acid biosynthesis aromatic amino acid family metabolic process aromatic-amino-acid:2-oxoglutarate aminotransferase activity|2-aminoadipate transaminase activity cytoplasm
YLR434C_d YLR434C YLR434C hom Dubious 1.19114433322756 0.116798464185181 no 605 0.134590598542583 461 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF TSR2/YLR435W Unknown Unknown Unknown
YDL027C_p YDL027C YDL027C hom Uncharacterized 1.19001743658655 0.117019769411971 no 606 0.11244930905982 432 NA FT MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL027C is not an essential gene biological_process molecular_function mitochondrion
YER183C YER183C FAU1 hom Verified 1.18815673611029 0.117385832530306 no 607 0.123809760054994 467 NA FT COFACTOR METABOLISM MITOCHONDRION 5,10-methenyltetrahydrofolate synthetase, involved in folic acid biosynthesis folic acid-containing compound biosynthetic process 5-formyltetrahydrofolate cyclo-ligase activity mitochondrion
YDR147W YDR147W EKI1 hom Verified 1.1870083684053 0.117612159824547 no 608 0.111907455700167 420 NA FT LIPID METABOLISM Ethanolamine kinase; primarily responsible for phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway; exhibits some choline kinase activity, thus contributing to phosphatidylcholine synthesis via the CDP-choline pathway; EKI1 has a paralog, CKI1, that arose from the whole genome duplication phosphatidylethanolamine biosynthetic process|phosphatidylcholine biosynthetic process ethanolamine kinase activity|choline kinase activity cytoplasm
YER014W YER014W HEM14 hom Verified 1.18271490056663 0.118461078395472 no 609 0.145405462683106 523 NA FT OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM MITOCHONDRION Protoporphyrinogen oxidase, a mitochondrial enzyme that catalyzes the seventh step in the heme biosynthetic pathway, converting protoporphyrinogen IX to protoporphyrin IX; inhibited by diphenyl ether-type herbicides heme biosynthetic process oxygen-dependent protoporphyrinogen oxidase activity mitochondrion|mitochondrial inner membrane
YNL230C YNL230C ELA1 hom Verified 1.17987086193416 0.119025790210491 no 610 0.128608400499772 479 NA FT PROTEOLYSIS NUCLEUS UBIQUITIN LIGASE COMPLEX Elongin A; F-box protein that forms a heterodimer with Elc1p and is required for ubiquitin-dependent degradation of the RNA Polymerase II subunit Rpo21p; subunit of the Elongin-Cullin-Socs (ECS) ligase complex protein ubiquitination involved in ubiquitin-dependent protein catabolic process ubiquitin-protein ligase activity elongin complex|Cul3-RING ubiquitin ligase complex
YHR097C_p YHR097C YHR097C hom Uncharacterized 1.17978185011441 0.119043495005704 no 611 0.11507150432473 420 NA FT NUCLEUS Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus biological_process molecular_function nucleus|cytoplasm
YDL116W YDL116W NUP84 hom Verified 1.1791724240129 0.119164762161576 no 612 0.118215157868551 497 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|RIBOSOME BIOGENESIS|RESPONSE TO DNA DAMAGE|RNA LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS NUCLEAR PORE Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport and NPC biogenesis; also plays roles in several processes that may require localization of genes or chromosomes at the nuclear periphery, including double-strand break repair, transcription and chromatin silencing; homologous to human NUP107 double-strand break repair|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|maintenance of chromatin silencing at telomere|nuclear pore distribution|telomere tethering at nuclear periphery|response to DNA damage stimulus|mRNA export from nucleus in response to heat stress|mRNA export from nucleus|positive regulation of transcription, DNA-dependent|protein import into nucleus|positive regulation of transcription from RNA polymerase II promoter|chromatin silencing at silent mating-type cassette structural constituent of nuclear pore integral to membrane|nuclear pore outer ring|nuclear pore
YDR439W YDR439W LRS4 hom Verified 1.17628060711865 0.11974138131102 no 613 0.137109413359632 546 NA FT PROTEIN LOCALIZATION|CELL CYCLE|CHROMOSOME SEGREGATION|GENE SILENCING NUCLEUS|CHROMOSOME KINETOCHORE Nucleolar protein that forms a complex with Csm1p, and then Mam1p at kinetochores during meiosis I to mediate accurate homolog segregation; required for condensin recruitment to the replication fork barrier site and rDNA repeat segregation rDNA condensation|chromatin silencing at rDNA|homologous chromosome segregation|protein localization to nucleolar rDNA repeats molecular_function nucleolus|nucleus|monopolin complex
YJL022W_d YJL022W YJL022W hom Dubious 1.17546222968857 0.119904919791509 no 614 0.128021135761222 415 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PET130 Unknown Unknown Unknown
YHR014W YHR014W SPO13 hom Verified 1.17476661380968 0.120044050262376 no 615 0.0882249627849464 328 NA FT PROTEIN LOCALIZATION|CELL CYCLE|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME Meiosis-specific protein, involved in maintaining sister chromatid cohesion during meiosis I as well as promoting proper attachment of kinetochores to the spindle during meiosis I and meiosis II protein localization to chromosome, centromeric region|meiotic sister chromatid cohesion|positive regulation of sister chromatid cohesion molecular_function nucleus|condensed nuclear chromosome, centromeric region
YOR080W YOR080W DIA2 hom Verified 1.17276235711028 0.120445558698173 no 616 0.129220087233751 480 NA FT CELL CYCLE|PROTEOLYSIS NUCLEUS|CHROMOSOME UBIQUITIN LIGASE COMPLEX Origin-binding F-box protein; forms an SCF ubiquitin ligase complex with Skp1p and Cdc53p; plays a role in DNA replication; plays a role in transcription; required for correct assembly of RSC complex, correct RSC-mediated transcription regulation, and correct nucleosome positioning; involved in invasive and pseudohyphal growth; required to target Cdc6p for ubiquitin-mediated destruction during G1 phase SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|regulation of DNA replication|invasive growth in response to glucose limitation|protein ubiquitination ubiquitin-protein ligase activity|DNA replication origin binding SCF ubiquitin ligase complex|nucleus|nuclear replication fork
YJR005C-A_p YJR005C-A YJR005C-A hom Uncharacterized 1.17100095244385 0.120799197155512 no 617 0.10878406054541 396 NA Putative protein of unknown function; originally identified as a syntenic homolog of an Ashbya gossypii gene; YJR005C-A has a paralog, YGR169C-A, that arose from the whole genome duplication biological_process molecular_function cellular_component
YPR075C YPR075C OPY2 hom Verified 1.17060326740997 0.12087914168388 no 618 0.10169387933513 386 NA FT CELL CYCLE|SIGNALING PLASMA MEMBRANE Integral membrane protein that acts as a membrane anchor for Ste50p; involved in the signaling branch of the high-osmolarity glycerol (HOG) pathway and as a regulator of the filamentous growth pathway; overproduction blocks cell cycle arrest in the presence of mating pheromone; relocalizes from vacuole to plasma membrane upon DNA replication stress cell cycle arrest in response to pheromone|osmosensory signaling pathway molecular_function integral to membrane|plasma membrane|fungal-type vacuole|cytoplasm
YGR225W YGR225W AMA1 hom Verified 1.17023407367714 0.120953392076405 no 619 0.114442266483483 424 NA FT CELL CYCLE|CELL WALL ORG/BIOGENESIS|CELL DIVISION NUCLEUS UBIQUITIN LIGASE COMPLEX Activator of meiotic anaphase promoting complex (APC/C); Cdc20p family member; required for initiation of spore wall assembly; required for Clb1p degradation during meiosis ascospore wall assembly|positive regulation of protein catabolic process|ascospore formation|meiosis I enzyme activator activity anaphase-promoting complex
YKR035C_d YKR035C OPI8 hom Dubious 1.16940602076201 0.121120042619791 no 620 0.162230848788458 568 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene DID2/YKR035W-A Unknown Unknown Unknown
YNL025C YNL025C SSN8 hom Verified 1.16883647939863 0.121234759896083 no 621 0.139416123528868 524 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS NUCLEUS Cyclin-like component of the RNA polymerase II holoenzyme, involved in phosphorylation of the RNA polymerase II C-terminal domain; involved in glucose repression and telomere maintenance positive regulation of transcription from RNA polymerase II promoter during meiosis|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription by galactose|positive regulation of transcription from RNA polymerase II promoter cyclin-dependent protein kinase regulator activity mediator complex
YDR314C YDR314C RAD34 hom Verified 1.16879036153501 0.121244052319977 no 622 0.116623494682856 394 NA FT RESPONSE TO DNA DAMAGE NUCLEUS Protein involved in nucleotide excision repair (NER); homologous to RAD4 nucleotide-excision repair molecular_function nucleus
YGR183C YGR183C QCR9 hom Verified 1.16828079206372 0.121346760315684 no 623 0.121818051155693 469 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex iron-sulfur cluster assembly|mitochondrial electron transport, ubiquinol to cytochrome c|aerobic respiration ubiquinol-cytochrome-c reductase activity mitochondrion|integral to membrane|mitochondrial respiratory chain complex III
YJL208C YJL208C NUC1 hom Verified 1.16815873061571 0.121371371902769 no 624 0.12067730797267 442 NA FT NUCLEUS|MITOCHONDRION Major mitochondrial nuclease, has RNAse and DNA endo- and exonucleolytic activities; has roles in mitochondrial recombination, apoptosis and maintenance of polyploidy DNA catabolic process|RNA catabolic process|apoptotic process|DNA recombination ribonuclease activity|endodeoxyribonuclease activity|exodeoxyribonuclease activity mitochondrion|mitochondrial inner membrane|nucleus
YDR414C YDR414C ERD1 hom Verified 1.16781324578699 0.121441051988678 no 625 0.136034174693066 487 NA FT PROTEIN LOCALIZATION|CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Predicted membrane protein required for the retention of lumenal endoplasmic reticulum proteins; mutants secrete the endogenous ER protein, BiP (Kar2p) protein retention in ER lumen|protein glycosylation molecular_function integral to membrane|membrane
YPL106C YPL106C SSE1 hom Verified 1.16484556229559 0.122040756119256 no 626 0.140149303485666 516 NA ATPase component of the heat shock protein Hsp90 chaperone complex; binds unfolded proteins; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasm; SSE1 has a paralog, SSE2, that arose from the whole genome duplication protein folding|protein refolding peptide binding|adenyl-nucleotide exchange factor activity|ATP binding polysome|cytoplasm
YOR015W_d YOR015W YOR015W hom Dubious 1.16484052640829 0.122041775526725 no 627 0.110501162197574 426 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YDR406W YDR406W PDR15 hom Verified 1.1643875366821 0.122133498052394 no 628 0.113613413556559 412 NA FT NUCLEOTIDE METABOLISM Plasma membrane ATP binding cassette (ABC) transporter, multidrug transporter and general stress response factor implicated in cellular detoxification; regulated by Pdr1p, Pdr3p and Pdr8p; promoter contains a PDR responsive element transport|response to drug ATPase activity, coupled to transmembrane movement of substances integral to membrane
YJR036C YJR036C HUL4 hom Verified 1.16130463947455 0.122759016723672 no 629 0.126958403885682 447 NA FT PROTEOLYSIS NUCLEUS Protein with similarity to hect domain E3 ubiquitin-protein ligases; not essential for viability; found in association with Trf4 in TRAMP complex protein ubiquitination ubiquitin-protein ligase activity TRAMP complex
YDR116C YDR116C MRPL1 hom Verified 1.16012921421946 0.122998100704633 no 630 0.114784882627486 408 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YPL048W YPL048W CAM1 hom Verified 1.15876632747929 0.123275723199586 no 631 0.126587030484571 461 NA FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION NUCLEUS Nuclear protein required for transcription of MXR1; binds the MXR1 promoter in the presence of other nuclear factors; binds calcium and phospholipids; has similarity to translational cofactor EF-1 gamma ribosome biogenesis|positive regulation of transcription from RNA polymerase II promoter phospholipid binding|transcription coactivator activity|calcium ion binding nucleus
YMR326C_d YMR326C YMR326C hom Dubious 1.15823572868732 0.123383925791367 no 632 0.118878284091594 427 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the telomere on the right arm of chromosome 13 Unknown Unknown Unknown
YDL160C YDL160C DHH1 hom Verified 1.1579109005546 0.123450199335664 no 633 0.156697839564097 577 NA FF|FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|TRANSLATION|RNA LOCALIZATION Cytoplasmic DExD/H-box helicase, stimulates mRNA decapping; coordinates distinct steps in mRNA function and decay, interacts with both the decapping and deadenylase complexes, may have a role in mRNA export and translation; C-terminus of Dhh1p interacts with Ngr1p and promotes POR1, but not EDC1 mRNA decay; forms cytoplasmic foci upon DNA replication stress deadenylation-dependent decapping of nuclear-transcribed mRNA|cell morphogenesis involved in conjugation with cellular fusion|stress granule assembly|cytoplasmic mRNA processing body assembly protein binding|RNA helicase activity cytoplasmic mRNA processing body|cytoplasmic stress granule|cytoplasm
YDR063W YDR063W AIM7 hom Verified 1.15457453534361 0.124132349792593 no 634 0.102645768377786 368 NA FT CYTOSKELETON ORGANIZATION NUCLEUS|CYTOSKELETON Protein that interacts with Arp2/3 complex to stimulate actin filament debranching and inhibit actin nucleation; has similarity to Cof1p and also to human glia maturation factor (GMF); null mutant displays elevated mitochondrial genome loss actin filament debranching|negative regulation of Arp2/3 complex-mediated actin nucleation molecular_function nucleus|actin cortical patch|cytoplasm
YHR125W_d YHR125W YHR125W hom Dubious 1.15185339003157 0.124690662095238 no 635 0.137214799327421 554 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YLL047W_d YLL047W YLL047W hom Dubious 1.15082711152475 0.124901684377828 no 636 0.13681895430634 494 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene RNP1 Unknown Unknown Unknown
YER078C YER078C ICP55 hom Verified 1.15022272329562 0.125026074706545 no 637 0.122533859007328 455 NA FT PROTEOLYSIS NUCLEUS|MITOCHONDRION Mitochondrial aminopeptidase; cleaves the N termini of at least 38 imported proteins after cleavage by the mitochondrial processing peptidase (MPP), thereby increasing their stability; member of the aminopeptidase P family protein stabilization|protein processing aminopeptidase activity extrinsic to mitochondrial inner membrane|mitochondrion|nucleus
YLR168C YLR168C UPS2 hom Verified 1.14949641173057 0.125175672757503 no 638 0.124328484980296 479 NA FT LIPID METABOLISM|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial protein involved in phospholipid metabolism; localizes to the intermembrane space; has a role in regulation of phospholipid metabolism by inhibiting conversion of phosphatidylethanolamine to phosphatidylcholine; null mutant has defects in mitochondrial morphology; similar to Ups1p, Ups3p and to human PRELI cristae formation|Unknown|phosphatidylethanolamine metabolic process|cardiolipin metabolic process molecular_function extrinsic to mitochondrial inner membrane|mitochondrion|mitochondrial intermembrane space
YNL089C_d YNL089C YNL089C hom Dubious 1.14912927245551 0.125251339803065 no 639 0.123681268583322 479 NA Dubious open reading frame unlikely to encode a functional protein; almost completely overlaps YNL090W/RHO2 which encodes a small GTPase of the Rho/Rac subfamily of Ras-like proteins Unknown Unknown Unknown
YGL017W YGL017W ATE1 hom Verified 1.14809554935822 0.125464560649733 no 640 0.102616133372342 369 NA FT PROTEOLYSIS Arginyl-tRNA-protein transferase, catalyzes post-translational conjugation of arginine to the amino termini of acceptor proteins which are then subject to degradation via the N-end rule pathway cellular protein modification process|protein arginylation arginyltransferase activity cytoplasm
YDL041W_d YDL041W YDL041W hom Dubious 1.14802507487281 0.125479106284927 no 641 0.162057489820774 607 NA FF Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene SIR2/YDL042C Unknown Unknown Unknown
YKR020W YKR020W VPS51 hom Verified 1.14713311356436 0.125663305036093 no 642 0.167423723298708 590 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL DIVISION|VACUOLAR TRANSPORT GOLGI APPARATUS Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; links the (VFT/GARP) complex to the SNARE Tlg1p vesicle organization|retrograde transport, endosome to Golgi|budding cell apical bud growth|regulation of cell size|protein targeting to vacuole protein binding Golgi apparatus|GARP complex
YNR063W_p YNR063W YNR063W hom Uncharacterized 1.14657555141971 0.125778542857851 no 643 0.109410933197822 404 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Putative zinc-cluster protein of unknown function biological_process sequence-specific DNA binding cellular_component
YEL045C_d YEL045C YEL045C hom Dubious 1.14457428958346 0.126192773840936 no 644 0.163228617261266 561 NA Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; deletion gives MMS sensitivity, growth defect under alkaline conditions, less than optimal growth upon citric acid stress Unknown Unknown Unknown
YOR337W YOR337W TEA1 hom Verified 1.14007290232566 0.127127965071496 no 645 0.125607267253788 485 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Ty1 enhancer activator required for full levels of Ty enhancer-mediated transcription; C6 zinc cluster DNA-binding protein transcription, DNA-dependent sequence-specific DNA binding|DNA binding nucleus
YLR084C YLR084C RAX2 hom Verified 1.13979235561612 0.127186409625033 no 646 0.151689826473898 451 NA FT CELL CYCLE|CELL DIVISION MITOCHONDRION|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE N-glycosylated protein involved in the maintenance of bud site selection during bipolar budding; localization requires Rax1p; RAX2 mRNA stability is regulated by Mpt5p cellular bud site selection molecular_function mitochondrion|cellular bud scar|cellular bud neck|membrane
YDR258C YDR258C HSP78 hom Verified 1.13907339996171 0.127336270522076 no 647 0.104688703786545 389 NA FT PROTEIN LOCALIZATION|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Oligomeric mitochondrial matrix chaperone that cooperates with Ssc1p in mitochondrial thermotolerance after heat shock; able to prevent the aggregation of misfolded proteins as well as resolubilize protein aggregates positive regulation of mitochondrial translation in response to stress|protein refolding|protein stabilization|protein import into mitochondrial matrix|mitochondrial genome maintenance|protein unfolding|cellular response to heat misfolded protein binding|ATPase activity mitochondrion|mitochondrial matrix
YKL047W_p YKL047W ANR2 hom Uncharacterized 1.13901566118862 0.127348311060646 no 648 0.127277815346703 507 NA Putative protein of unknown function, predicted to be palmitoylated; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm biological_process molecular_function cytoplasm
YHL038C YHL038C CBP2 hom Verified 1.13403281442993 0.128390391839265 no 649 0.0938580453160128 360 NA FT RNA PROCESSING MITOCHONDRION Required for splicing of the group I intron bI5 of the COB pre-mRNA; nuclear-encoded mitochondrial protein that binds to the RNA to promote splicing; also involved in but not essential for splicing of the COB bI2 intron and the intron in the 21S rRNA gene Group I intron splicing RNA binding mitochondrion
YEL057C_p YEL057C YEL057C hom Uncharacterized 1.13197081711868 0.128823351828625 no 650 0.100958452818818 371 NA Protein of unknown function involved in telomere maintenance; target of UME6 regulation biological_process molecular_function cellular_component
YIL085C YIL085C KTR7 hom Verified 1.13195517127582 0.128826640871511 no 651 0.119965330061379 451 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM GOLGI APPARATUS Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; KTR7 has a paralog, KTR5, that arose from the whole genome duplication fungal-type cell wall organization|protein N-linked glycosylation mannosyltransferase activity Golgi apparatus
YER017C YER017C AFG3 hom Verified 1.13096619560942 0.129034659901574 no 652 0.168676657555029 580 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Component, with Yta12p, of the mitochondrial inner membrane m-AAA protease; mediates degradation of misfolded or unassembled proteins and is also required for correct assembly of mitochondrial enzyme complexes; involved in cytoplasmic mRNA translation and aging proteolysis|signal peptide processing|protein complex assembly|protein import into mitochondrial intermembrane space metallopeptidase activity|protein binding|ATPase activity mitochondrion|mitochondrial inner boundary membrane|mitochondrial inner membrane|m-AAA complex
YPL216W_p YPL216W YPL216W hom Uncharacterized 1.13062898560038 0.12910564115324 no 653 0.128243730657776 489 NA FT CHROMATIN ORGANIZATION NUCLEUS Putative protein of unknown function; YPL216W is not an essential gene biological_process molecular_function cellular_component
YLR169W_d YLR169W YLR169W hom Dubious 1.13004642698732 0.129228331001158 no 654 0.108413495212576 406 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YNR024W YNR024W MPP6 hom Verified 1.12979412089648 0.12928149303816 no 655 0.127245469749698 472 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Nuclear exosome-associated RNA binding protein; involved in surveillance of pre-rRNAs and pre-mRNAs, and the degradation of cryptic non-coding RNAs (ncRNA); copurifies with ribosomes nuclear mRNA surveillance of spliceosomal pre-mRNA splicing|nuclear mRNA surveillance of mRNA 3'-end processing|nuclear polyadenylation-dependent CUT catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) poly(U) RNA binding ribosome|nucleus|nuclear exosome (RNase complex)|TRAMP complex
YGR117C_p YGR117C YGR117C hom Uncharacterized 1.12579466438186 0.130126221569892 no 656 0.0972305150971584 321 NA Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm biological_process molecular_function cytoplasm
YKL062W YKL062W MSN4 hom Verified 1.1249996366053 0.130294594131675 no 657 0.124505630997105 438 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO NUTRIENT LEVELS|RESPONSE TO OXIDATIVE STRESS NUCLEUS Transcriptional activator; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression; MSN4 has a paralog, MSN2, that arose from the whole genome duplication positive regulation of transcription from RNA polymerase II promoter in response to heat stress|positive regulation of transcription from RNA polymerase II promoter in response to a hypotonic environment|positive regulation of transcription from RNA polymerase II promoter in response to alkalinity|positive regulation of transcription from RNA polymerase II promoter in response to amino acid starvation|positive regulation of transcription from RNA polymerase II promoter in response to zinc ion starvation|positive regulation of transcription from RNA polymerase II promoter in response to acidity|chromatin remodeling|regulation of replicative cell aging by regulation of transcription from RNA polymerase II promoter in response to caloric restriction|positive regulation of transcription from RNA polymerase II promoter in response to hydrogen peroxide|positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance|positive regulation of transcription from RNA polymerase II promoter in response to increased salt|cellular response to acidity|positive regulation of transcription from RNA polymerase II promoter in response to freezing|positive regulation of transcription from RNA polymerase II promoter in response to ethanol|replicative cell aging|age-dependent response to oxidative stress involved in chronological cell aging|positive regulation of transcription from RNA polymerase II promoter in response to hydrostatic pressure|positive regulation of transcription from RNA polymerase II promoter in response to nitrosative stress|positive regulation of transcription from RNA polymerase II promoter in response to cold|positive regulation of transcription from RNA polymerase II promoter in response to glucose starvation RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity|core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding cytosol|nucleus
YPL014W_p YPL014W YPL014W hom Uncharacterized 1.12430774801102 0.13044124628225 no 658 0.141161913079744 524 NA FT NUCLEUS Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus biological_process molecular_function nucleus|cytoplasm
YPL173W YPL173W MRPL40 hom Verified 1.12384740984785 0.130538882413694 no 659 0.146225614730235 543 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YNL173C YNL173C MDG1 hom Verified 1.12360425121617 0.130590475910412 no 660 0.145389996140408 529 NA FT SIGNALING PLASMA MEMBRANE Plasma membrane protein involved in G-protein mediated pheromone signaling pathway; overproduction suppresses bem1 mutations pheromone-dependent signal transduction involved in conjugation with cellular fusion molecular_function membrane raft|plasma membrane
YLR043C YLR043C TRX1 hom Verified 1.12207449291888 0.13091538401615 no 661 0.12698098222327 526 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|RESPONSE TO OXIDATIVE STRESS ENDOMEMBRANE SYSTEM|NUCLEUS|GOLGI APPARATUS Cytoplasmic thioredoxin isoenzyme; part of the thioredoxin system which protects cells against oxidative and reductive stress; forms LMA1 complex with Pbi2p; acts as a cofactor for Tsa1p, required for ER-Golgi transport and vacuole inheritance; protein abundance increases in response to DNA replication stress vacuole inheritance|regulation of DNA replication|cell redox homeostasis|protein deglutathionylation|retrograde vesicle-mediated transport, Golgi to ER|cellular response to oxidative stress|ER to Golgi vesicle-mediated transport|vacuole fusion, non-autophagic disulfide oxidoreductase activity cytosol|fungal-type vacuole
YFR054C_d YFR054C YFR054C hom Dubious 1.12137962761709 0.131063152047662 no 662 0.108290677992925 415 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YGL139W YGL139W FLC3 hom Verified 1.11796824829233 0.131790277270494 no 663 0.114131353111171 374 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION Putative FAD transporter, similar to Flc1p and Flc2p; localized to the ER FAD transport|transmembrane transport FAD transmembrane transporter activity mitochondrion|integral to membrane|endoplasmic reticulum
YER134C YER134C YER134C hom Verified 1.11773312347184 0.131840495741811 no 664 0.130086336218611 479 NA FT NUCLEUS Magnesium-dependent acid phosphatase, member of the haloacid dehalogenase superfamily; non-essential gene biological_process acid phosphatase activity nucleus|cytoplasm
YMR013W-A_d YMR013W-A YMR013W-A hom Dubious 1.11537860063358 0.132344107875967 no 665 0.121898472720641 427 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the characterized snoRNA gene snR73 Unknown Unknown Unknown
YDR197W YDR197W CBS2 hom Verified 1.11525942468641 0.132369633789822 no 666 0.165384695964444 559 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial translational activator of the COB mRNA; interacts with translating ribosomes, acts on the COB mRNA 5'-untranslated leader mitochondrial respiratory chain complex III biogenesis|positive regulation of mitochondrial translation translation regulator activity mitochondrion|extrinsic to mitochondrial inner membrane|mitochondrial ribosome
YGL154C YGL154C LYS5 hom Verified 1.11274338390983 0.132909328587649 no 667 0.109136859770698 389 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Phosphopantetheinyl transferase involved in lysine biosynthesis; converts inactive apo-form of Lys2p (alpha-aminoadipate reductase) into catalytically active holo-form by posttranslational addition of phosphopantetheine lysine biosynthetic process via aminoadipic acid|protein-cofactor linkage holo-[acyl-carrier-protein] synthase activity cytoplasm
YNL236W YNL236W SIN4 hom Verified 1.11252289015435 0.132956696952285 no 668 0.172391591578277 644 NA FF|FT TRANSCRIPTION FROM RNA POL II NUCLEUS RNA POL II, HOLOENZYME Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; contributes to both postive and negative transcriptional regulation; dispensible for basal transcription negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II transcriptional preinitiation complex assembly|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II activating transcription factor binding core mediator complex
YDR098C YDR098C GRX3 hom Verified 1.11172799496052 0.133127559641577 no 669 0.117971112359186 402 NA FT ION HOMEOSTASIS|CYTOSKELETON ORGANIZATION|ION HOMEOSTASIS|RESPONSE TO OXIDATIVE STRESS NUCLEUS Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx4p and Grx5p; protects cells from oxidative damage; evidence exists indicating that the translation start site is not Met1 as currently annotated, but rather Met36 cellular iron ion homeostasis|cellular response to oxidative stress|actin cytoskeleton organization disulfide oxidoreductase activity cytosol|nucleus
YKL191W YKL191W DPH2 hom Verified 1.11027029497584 0.133441284720339 no 670 0.116698950744881 441 NA Protein required, along with Dph1p, Kti11p, Jjj3p, and Dph5p, for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); may act in a complex with Dph1p and Kti11p peptidyl-diphthamide biosynthetic process from peptidyl-histidine molecular_function cytoplasm
YBR181C YBR181C RPS6B hom Verified 1.1094175150155 0.133625054960318 no 671 0.133570109746983 492 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S6, no bacterial homolog; RPS6B has a paralog, RPS6A, that arose from the whole genome duplication cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) structural constituent of ribosome small-subunit processome|cytosolic small ribosomal subunit|cytoplasm
YBR196C-B_p YBR196C-B YBR196C-B hom Uncharacterized 1.10884766546389 0.133747951922686 no 672 0.12114073854328 453 NA Putative protein of unknown function; identified by expression profiling and mass spectrometry biological_process molecular_function cellular_component
YER101C YER101C AST2 hom Verified 1.10739291237921 0.13406204446508 no 673 0.136479515897217 532 NA FT PROTEIN LOCALIZATION|OXIDATION-REDUCTION PROCESS Lipid raft associated protein; overexpression restores Pma1p localization to lipid rafts which is required for targeting of Pma1p to the plasma membrane; sometimes classified in the medium-chain dehydrogenase/reductases (MDRs) superfamily; AST2 has a paralog, AST1, that arose from the whole genome duplication protein targeting to membrane molecular_function cytoplasm
YJL172W YJL172W CPS1 hom Verified 1.10562001124259 0.134445512307794 no 674 0.153375377121505 449 NA FT PROTEOLYSIS Vacuolar carboxypeptidase yscS; expression is induced under low-nitrogen conditions nitrogen compound metabolic process|proteolysis involved in cellular protein catabolic process carboxypeptidase activity fungal-type vacuole lumen
YBR196C-A_p YBR196C-A YBR196C-A hom Uncharacterized 1.10432506254199 0.134726077381115 no 675 0.169996205337248 567 NA Putative protein of unknown function; identified by fungal homology and RT-PCR biological_process molecular_function cellular_component
YJL078C YJL078C PRY3 hom Verified 1.10431441282087 0.134728386426372 no 676 0.101602049168175 377 NA Cell wall-associated protein involved in export of acetylated sterols; member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis related 1 proteins); role in mating efficiency; expression of full-length transcript is daughter cell-specific; in response to alpha factor, a short transcript starting at +452 is expressed and the long form is repressed by Ste12p biological_process molecular_function fungal-type cell wall
YAL002W YAL002W VPS8 hom Verified 1.10248559479685 0.135125308852556 no 677 0.139957395827227 532 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT GOLGI APPARATUS Membrane-binding component of the CORVET complex; involved in endosomal vesicle tethering and fusion in the endosome to vacuole protein targeting pathway; interacts with Vps21p; contains RING finger motif late endosome to vacuole transport via multivesicular body sorting pathway|protein targeting to vacuole GTPase binding|protein anchor late endosome|membrane|CORVET complex
YLR216C YLR216C CPR6 hom Verified 1.10136468331597 0.135368984841213 no 678 0.102863242241656 363 NA Peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity; protein abundance increases in response to DNA replication stress protein folding|protein refolding unfolded protein binding|peptidyl-prolyl cis-trans isomerase activity cytoplasm
YER119C-A_d YER119C-A YER119C-A hom Dubious 1.09136590484502 0.137555954376981 no 679 0.177808642429313 662 NA FF Dubious open reading frame, not conserved in closely related Saccharomyces species; deletion mutation blocks replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene SCS2 Unknown Unknown Unknown
YGR290W_d YGR290W YGR290W hom Dubious 1.08744952833257 0.138419096313187 no 680 0.148146145384291 536 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; putative HLH protein; partially overlaps the verified ORF MAL11/YGR289C (a high-affinity maltose transporter) Unknown Unknown Unknown
YDR075W YDR075W PPH3 hom Verified 1.08353122829297 0.139286348732516 no 681 0.114720639433582 444 NA FT CELL CYCLE|SIGNALING|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME Catalytic subunit of protein phosphatase PP4 complex; active complex is composed of Pph3p and Psy2p, with Psy4p apparently providing additional substrate specificity in some cases; regulates recovery from the DNA damage checkpoint and also the gene conversion- and single-strand annealing-mediated pathways of meiotic double-strand break repair; involved in activation of Gln3p to alleviate nitrogen catabolite repression; Pph3p and Psy2p localize to foci on meiotic chromosomes Unknown|signal transduction involved in meiotic recombination checkpoint|double-strand break repair via homologous recombination|protein dephosphorylation|positive regulation of nitrogen compound metabolic process protein serine/threonine phosphatase activity condensed nuclear chromosome|nucleus|cytoplasm
YNL045W YNL045W LAP2 hom Verified 1.08301222693614 0.139401497986579 no 682 0.124195152031599 424 NA FT KETONE METABOLISM|LIPID METABOLISM|PROTEOLYSIS NUCLEUS Leucyl aminopeptidase yscIV (leukotriene A4 hydrolase) with epoxide hydrolase activity, metalloenzyme containing one zinc atom; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus cellular lipid metabolic process|protein catabolic process aminopeptidase activity|leukotriene-A4 hydrolase activity|epoxide hydrolase activity nucleus|cytoplasm
YCR044C YCR044C PER1 hom Verified 1.08219605086794 0.139582711453631 no 683 0.249576400279924 819 NA FF|FT LIPID METABOLISM|ION HOMEOSTASIS|ION HOMEOSTASIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Protein of the endoplasmic reticulum, required for GPI-phospholipase A2 activity that remodels the GPI anchor as a prerequisite for association of GPI-anchored proteins with lipid rafts; functionally complemented by human ortholog PERLD1 GPI anchor biosynthetic process|cellular manganese ion homeostasis molecular_function fungal-type vacuole membrane|integral to membrane|endoplasmic reticulum
YLR303W YLR303W MET17 hom Verified 1.08182102379416 0.139666031439807 no 684 0.147989543328088 552 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Methionine and cysteine synthase (O-acetyl homoserine-O-acetyl serine sulfhydrylase), required for sulfur amino acid synthesis methionine metabolic process|cysteine biosynthetic process O-acetylhomoserine aminocarboxypropyltransferase activity|cysteine synthase activity plasma membrane|cytoplasm
YLL024C YLL024C SSA2 hom Verified 1.08109791932649 0.139826779433132 no 685 0.122996964628289 460 NA FT PROTEIN LOCALIZATION MITOCHONDRION ATP binding protein involved in protein folding and vacuolar import of proteins; member of heat shock protein 70 (HSP70) family; associated with the chaperonin-containing T-complex; present in the cytoplasm, vacuolar membrane and cell wall; 98% identical with paralog Ssa1p, but subtle differences between the two proteins provide functional specificity with respect to propagation of yeast [URE3] prions and vacuolar-mediated degradations of gluconeogenesis enzymes protein folding|SRP-dependent cotranslational protein targeting to membrane, translocation|response to stress unfolded protein binding|ATPase activity|ATP binding cytosol|fungal-type vacuole membrane|mitochondrion|fungal-type cell wall|plasma membrane|polysome|chaperonin-containing T-complex|cytoplasm
YMR190C YMR190C SGS1 hom Verified 1.08056709231861 0.139944863664927 no 686 0.132164182419517 495 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME Nucleolar DNA helicase of the RecQ family; involved in genome integrity maintenance; regulates chromosome synapsis and meiotic joint molecule/crossover formation; potential role as repressor of a subset of rapamycin responsive genes; rapidly lost in response to rapamycin in Rrd1p-dependent manner; similar to human BLM and WRN proteins implicated in Bloom and Werner syndromes; forms nuclear foci upon DNA replication stress DNA double-strand break processing|meiotic DNA double-strand break processing|telomeric 3' overhang formation|meiotic chromosome segregation|DNA unwinding involved in replication|double-strand break repair via homologous recombination|intra-S DNA damage checkpoint|telomere maintenance via recombination|replicative cell aging|DNA duplex unwinding|response to DNA damage stimulus|negative regulation of meiotic joint molecule formation|chromosome organization|regulation of reciprocal meiotic recombination|gene conversion at mating-type locus, DNA double-strand break processing|mitotic sister chromatid segregation ATP-dependent DNA helicase activity RecQ helicase-Topo III complex|nucleolus
YIL047C YIL047C SYG1 hom Verified 1.07985262021985 0.140103907324039 no 687 0.135925583017168 519 NA FT SIGNALING MITOCHONDRION|PLASMA MEMBRANE Plasma membrane protein of unknown function; truncation and overexpression suppresses lethality of G-alpha protein deficiency signal transduction molecular_function mitochondrion|integral to membrane|plasma membrane
YOR053W_d YOR053W YOR053W hom Dubious 1.07663690868763 0.140821254248668 no 688 0.126858675735718 503 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VHS3/YOR054C Unknown Unknown Unknown
YDR159W YDR159W SAC3 hom Verified 1.0746103108873 0.141274616793131 no 689 0.210277739513604 757 NA FF|FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|RIBOSOME BIOGENESIS|RESPONSE TO DNA DAMAGE|RNA LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS NUCLEAR PORE Nuclear pore-associated protein; required for biogenesis of the small ribosomal subunit; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; similar to the human germinal center-associated nuclear protein (GANP) ribosomal small subunit biogenesis|actin filament-based process|mRNA export from nucleus|mRNA 3'-end processing|mitosis|protein export from nucleus|transcription-coupled nucleotide-excision repair|nuclear retention of pre-mRNA at the site of transcription|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery protein binding transcription export complex 2|nuclear pore
YDL026W_d YDL026W YDL026W hom Dubious 1.07459802206209 0.14127736889446 no 690 0.152457704825184 534 NA Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YIR035C_p YIR035C YIR035C hom Uncharacterized 1.07226926892938 0.141799552819533 no 691 0.11813510396446 451 NA FT OXIDATION-REDUCTION PROCESS Putative cytoplasmic short-chain dehydrogenase/reductase biological_process molecular_function integral to membrane|cytoplasm
YPL041C_p YPL041C YPL041C hom Uncharacterized 1.07063084245646 0.142167724909606 no 692 0.137121450865482 428 NA Protein of unknown function involved in maintenance of proper telomere length biological_process molecular_function cellular_component
YPR076W_d YPR076W YPR076W hom Dubious 1.0675807356101 0.142854838642601 no 693 0.157394511592107 577 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YOR131C YOR131C YOR131C hom Verified 1.06729531389526 0.142919251759229 no 694 0.158176211784293 561 NA FT NUCLEUS Putative haloacid dehalogenase-like hydrolase; non-essential gene; overexpression causes a cell cycle delay or arrest; protein abundance increases in response to DNA replication stress biological_process molecular_function nucleus|cytoplasm
YER129W YER129W SAK1 hom Verified 1.06514296845036 0.143405618668214 no 695 0.158349674722797 561 NA FT CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION Upstream serine/threonine kinase for the SNF1 complex; partially redundant with Elm1p and Tos3p; members of this family have functional orthology with LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome protein phosphorylation|glucose metabolic process|DNA-dependent DNA replication protein serine/threonine kinase activity|protein kinase activity cytoplasm
YLR436C YLR436C ECM30 hom Verified 1.0644590989874 0.143560386773929 no 696 0.163047225524088 571 NA FT CELL WALL ORG/BIOGENESIS Putative protein of unknown function; may play a role in cell wall biosynthesis, mutants have abormal relative levels of mannose and glucose and have Gap1p sorting and transport defects; (GFP)-fusion protein localizes to the cytoplasm fungal-type cell wall organization molecular_function cytoplasm
YDR330W YDR330W UBX5 hom Verified 1.06442821109811 0.143567379744876 no 697 0.113091677526027 371 NA FT PROTEOLYSIS NUCLEUS UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p proteasomal ubiquitin-dependent protein catabolic process molecular_function nucleus|cytoplasm
YLR067C YLR067C PET309 hom Verified 1.0640479273848 0.143653494237609 no 698 0.150765277973246 540 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Specific translational activator for the COX1 mRNA, also influences stability of intron-containing COX1 primary transcripts; localizes to the mitochondrial inner membrane; contains seven pentatricopeptide repeats (PPRs) positive regulation of mitochondrial translational initiation|RNA metabolic process|mitochondrial respiratory chain complex IV biogenesis|aerobic respiration translation regulator activity extrinsic to mitochondrial inner membrane|mitochondrion|integral to membrane|mitochondrial inner membrane
YJL112W YJL112W MDV1 hom Verified 1.0632175649456 0.143841649303311 no 699 0.165128679380666 574 NA FT MITOCHONDRION ORGANIZATION|PEROXISOME ORGANIZATION MITOCHONDRION Peripheral protein of cytosolic face of mitochondrial outer membrane; required for mitochondrial fission; interacts with Fis1p and with the dynamin-related GTPase Dnm1p; contains WD repeats; MDV1 has a paralog, CAF4, that arose from the whole genome duplication peroxisome fission|mitochondrial fission|mitochondrial genome maintenance ubiquitin binding mitochondrial outer membrane|mitochondrion
YOR360C YOR360C PDE2 hom Verified 1.06029846853028 0.144504417876708 no 700 0.165133786239557 533 NA FT SIGNALING NUCLEUS High-affinity cyclic AMP phosphodiesterase, component of the cAMP-dependent protein kinase signaling system, protects the cell from extracellular cAMP, contains readthrough motif surrounding termination codon cAMP-mediated signaling 3',5'-cyclic-AMP phosphodiesterase activity nucleus|cytoplasm
YOR120W YOR120W GCY1 hom Verified 1.06026862521796 0.144511204283693 no 701 0.18270462296053 607 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|RESPONSE TO OXIDATIVE STRESS NUCLEUS Glycerol dehydrogenase;involved in an alternative pathway for glycerol catabolism used under microaerobic conditions; also has mRNA binding activity; member of the aldo-keto reductase (AKR) family; protein abundance increases in response to DNA replication stress; GCY1 has a paralog, YPR1, that arose from the whole genome duplication cellular response to oxidative stress|arabinose catabolic process|D-xylose catabolic process oxidoreductase activity|mRNA binding|alditol:NADP+ 1-oxidoreductase activity|aldo-keto reductase (NADP) activity nucleus|cytoplasm
YFL034W_p YFL034W YFL034W hom Uncharacterized 1.05971104714264 0.1446380377302 no 702 0.148327103646171 563 NA Putative integral membrane protein that interacts with Rpp0p, which is a component of the ribosomal stalk biological_process molecular_function integral to membrane
YLR268W YLR268W SEC22 hom Verified 1.05919045881987 0.144756524710204 no 703 0.212433511051005 747 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS R-SNARE protein; assembles into SNARE complex with Bet1p, Bos1p and Sed5p; cycles between the ER and Golgi complex; involved in anterograde and retrograde transport between the ER and Golgi; synaptobrevin homolog retrograde vesicle-mediated transport, Golgi to ER|ER to Golgi vesicle-mediated transport|vesicle fusion with Golgi apparatus|vesicle fusion with endoplasmic reticulum|vesicle fusion SNAP receptor activity SNARE complex|integral to membrane|Golgi apparatus|endoplasmic reticulum|ER to Golgi transport vesicle membrane
YLR351C YLR351C NIT3 hom Verified 1.05844165157534 0.14492706939618 no 704 0.125107055316196 455 NA FT MITOCHONDRION Nit protein, one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member biological_process hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds mitochondrion|cytoplasm
YJL138C YJL138C TIF2 hom Verified 1.05633229159531 0.145408213943098 no 705 0.131635877852602 496 NA FT TRANSLATION RIBOSOME Translation initiation factor eIF4A; DEA(D/H)-box RNA helicase that couples ATPase activity to RNA binding and unwinding; forms a dumbbell structure of two compact domains connected by a linker; interacts with eIF4G; protein abundance increases in response to DNA replication stress; TIF2 has a paralog, TIF1, that arose from the whole genome duplication translational initiation|regulation of translational initiation ATP-dependent RNA helicase activity|translation initiation factor activity ribosome|eukaryotic translation initiation factor 4F complex|plasma membrane|cytoplasm
YKL079W YKL079W SMY1 hom Verified 1.05627793734227 0.145420626319634 no 706 0.123218170976221 439 NA FT VESICLE-MEDIATED TRANSPORT SITE OF POLARIZED GROWTH|CYTOSKELETON Protein that interacts with Myo2p, proposed to be involved in exocytosis; N-terminal domain is related to the motor domain of kinesins exocytosis motor activity incipient cellular bud site|cellular bud neck|mating projection tip|cellular bud tip
YMR157C YMR157C AIM36 hom Verified 1.05616038571766 0.145447472930918 no 707 0.151750245375691 568 NA FT MITOCHONDRION Protein of unknown function; null mutant displays reduced respiratory growth and elevated frequency of mitochondrial genome loss; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies biological_process molecular_function mitochondrion
YNR036C YNR036C MRPS12 hom Verified 1.05090383028567 0.146651380523336 no 708 0.159646357639858 576 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial protein; may interact with ribosomes based on co-purification experiments; similar to E. coli and human mitochondrial S12 ribosomal proteins mitochondrial translation structural constituent of ribosome mitochondrion|ribosome|mitochondrial small ribosomal subunit
YPL253C YPL253C VIK1 hom Verified 1.05064231098586 0.146711450341942 no 709 0.150181560439398 576 NA FT CELL CYCLE|CHROMOSOME SEGREGATION NUCLEUS|CYTOSKELETON Protein that forms a complex with Kar3p at the spindle pole body, possible regulator of Kar3p function in microtubule-mediated processes; required for sister chromatid cohesion; has similarity to Cik1p microtubule-based process|mitotic sister chromatid cohesion microtubule motor activity kinesin complex|spindle pole body
YIL153W YIL153W RRD1 hom Verified 1.05052456891736 0.146738500559726 no 710 0.168096534227256 620 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|RESPONSE TO DNA DAMAGE|CYTOSKELETON ORGANIZATION NUCLEUS|CHROMOSOME Peptidyl-prolyl cis/trans-isomerase; activator of the phosphotyrosyl phosphatase activity of PP2A; involved in G1 phase progression, microtubule dynamics, bud morphogenesis and DNA repair; required for rapid reduction of Sgs1p levels in response to rapamycin; subunit of the Tap42p-Sit4p-Rrd1p complex; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress DNA repair|mitotic spindle organization in nucleus|G1/S transition of mitotic cell cycle|response to osmotic stress|regulation of transcription from RNA polymerase II promoter in response to stress peptidyl-prolyl cis-trans isomerase activity|protein phosphatase type 2A regulator activity nuclear chromatin|nucleus|cytoplasm
YGL136C YGL136C MRM2 hom Verified 1.04933805838345 0.147011277814369 no 711 0.115478258062516 399 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS MITOCHONDRION Mitochondrial 2' O-ribose methyltransferase, required for methylation of U(2791) in 21S rRNA; MRM2 deletion confers thermosensitive respiration and loss of mitochondrial DNA; has similarity to Spb1p and Trm7p, and to E. coli FtsJ/RrmJ rRNA methylation rRNA (uridine-2'-O-)-methyltransferase activity mitochondrion
YNL241C YNL241C ZWF1 hom Verified 1.0476883630538 0.147391105390486 no 712 0.136304210809722 507 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS Glucose-6-phosphate dehydrogenase (G6PD); catalyzes the first step of the pentose phosphate pathway; involved in adapting to oxidatve stress; homolog of the human G6PD which is deficient in patients with hemolytic anemia; protein abundance increases in response to DNA replication stress NADPH regeneration|response to hydrogen peroxide|pentose-phosphate shunt, oxidative branch|carbon catabolite repression of transcription glucose-6-phosphate dehydrogenase activity cytoplasm
YML074C YML074C FPR3 hom Verified 1.04622916868319 0.147727619442675 no 713 0.127339259562954 419 NA FT CELL CYCLE|CHROMATIN ORGANIZATION NUCLEUS Nucleolar peptidyl-prolyl cis-trans isomerase (PPIase); FK506 binding protein; phosphorylated by casein kinase II (Cka1p-Cka2p-Ckb1p-Ckb2p) and dephosphorylated by Ptp1p meiotic recombination checkpoint peptidyl-prolyl cis-trans isomerase activity|macrolide binding nucleolus
YDR452W YDR452W PPN1 hom Verified 1.04508547652368 0.147991732932934 no 714 0.191276591744981 525 NA FT NUCLEUS Vacuolar endopolyphosphatase with a role in phosphate metabolism; functions as a homodimer; relocalizes from vacuole to cytoplasm upon DNA replication stress polyphosphate catabolic process|polyphosphate metabolic process endopolyphosphatase activity|exopolyphosphatase activity fungal-type vacuole membrane|nucleus
YDR124W_p YDR124W YDR124W hom Uncharacterized 1.04291606135018 0.148493585099082 no 715 0.135381424455718 490 NA Putative protein of unknown function; non-essential gene; expression is strongly induced by alpha factor biological_process molecular_function cellular_component
YGR200C YGR200C ELP2 hom Verified 1.04227192610152 0.148642812163456 no 716 0.17053550664861 596 NA FT PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|RNA PROCESSING NUCLEUS Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; target of Kluyveromyces lactis zymocin regulation of transcription from RNA polymerase II promoter|protein urmylation|tRNA wobble uridine modification molecular_function Elongator holoenzyme complex|nucleus|cytoplasm
YPL161C YPL161C BEM4 hom Verified 1.04217321886373 0.148665688563113 no 717 0.24115817858485 820 NA FF|FT SIGNALING|CYTOSKELETON ORGANIZATION NUCLEUS Protein involved in establishment of cell polarity and bud emergence; interacts with the Rho1p small GTP-binding protein and with the Rho-type GTPase Cdc42p; involved in maintenance of proper telomere length establishment of cell polarity|Rho protein signal transduction|actin cytoskeleton organization molecular_function nucleus|cytoplasm
YDR347W YDR347W MRP1 hom Verified 1.04112050795105 0.148909811347708 no 718 0.160887427693543 567 NA FT TRANSLATION|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the small subunit; MRP1 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator, and with PET123, encoding a small subunit mitochondrial ribosomal protein mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial small ribosomal subunit
YIR003W YIR003W AIM21 hom Verified 1.041096533674 0.148915374080275 no 719 0.129581642421257 461 NA FT SITE OF POLARIZED GROWTH|CYTOSKELETON Protein of unknown function involved in mitochondrial migration along actin filament; may interact with ribosomes; GFP-fusion protein colocalizes with Sac1p to the actin cytoskeleton mitochondrion migration along actin filament molecular_function ribosome|mating projection tip|actin cytoskeleton
YGR288W YGR288W MAL13 hom Verified 1.03936548385179 0.149317395165615 no 720 0.14683301439081 541 NA FT TRANSCRIPTION FROM RNA POL II|CARBOHYDRATE METABOLISM NUCLEUS MAL-activator protein, part of complex locus MAL1; nonfunctional in genomic reference strain S288C cellular carbohydrate metabolic process|regulation of transcription, DNA-dependent sequence-specific DNA binding transcription factor activity nucleus
YMR116C YMR116C ASC1 hom Verified 1.03816588428989 0.149596416286207 no 721 0.154259873267525 575 NA FT SIGNALING|TRANSLATION RIBOSOME G-protein beta subunit and guanine nucleotide dissociation inhibitor for Gpa2p; ortholog of RACK1 that inhibits translation; core component of the small (40S) ribosomal subunit; regulates P-body formation induced by replication stress; represses Gcn4p in the absence of amino acid starvation negative regulation of translation|glucose mediated signaling pathway|G-protein coupled receptor signaling pathway|invasive growth in response to glucose limitation G-protein alpha-subunit binding|GDP-dissociation inhibitor activity|signal transducer activity cytosolic small ribosomal subunit|cytoplasm
YIL060W_p YIL060W YIL060W hom Uncharacterized 1.03812011987373 0.149607067755771 no 722 0.174033203470168 635 NA Putative protein of unknown function; mutant accumulates less glycogen than does wild type; null mutation results in a decrease in plasma membrane electron transport; YIL060W is not an essential gene biological_process molecular_function cellular_component
YJL080C YJL080C SCP160 hom Verified 1.03729641835043 0.149798867240964 no 723 0.138172929727302 554 NA FT CELL CYCLE|SIGNALING|RNA LOCALIZATION|CHROMOSOME SEGREGATION|GENE SILENCING ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM Essential RNA-binding G protein effector of mating response pathway, mainly associated with nuclear envelope and ER, interacts in mRNA-dependent manner with translating ribosomes via multiple KH domains, similar to vertebrate vigilins meiotic telomere clustering|pheromone-dependent signal transduction involved in conjugation with cellular fusion|chromosome segregation|intracellular mRNA localization|chromatin silencing at silent mating-type cassette|chromatin silencing at telomere G-protein alpha-subunit binding|RNA binding endoplasmic reticulum membrane|polysome|nuclear outer membrane-endoplasmic reticulum membrane network
YOR248W_d YOR248W YOR248W hom Dubious 1.03722124803816 0.149816378865027 no 724 0.138462691688648 505 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YOL039W YOL039W RPP2A hom Verified 1.03720461908201 0.149820252919611 no 725 0.172444986189131 577 NA FT TRANSLATION RIBOSOME Ribosomal protein P2 alpha, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm translational elongation|cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YDR074W YDR074W TPS2 hom Verified 1.03054461122886 0.151377210889031 no 726 0.233165487663301 787 NA FT CARBOHYDRATE METABOLISM MITOCHONDRION Phosphatase subunit of the trehalose-6-P synthase/phosphatase complex; involved in synthesis of the storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway; protein abundance increases in response to DNA replication stress trehalose biosynthetic process|response to stress trehalose-phosphatase activity mitochondrion|alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)
YGR165W YGR165W MRPS35 hom Verified 1.02925606860459 0.151679680624973 no 727 0.194543226697748 676 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the small subunit; null mutant does not grow on glycerol, is sensitive to 2,4-dichlorophenol, and accumulates large lipid droplets mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial small ribosomal subunit
YLR325C YLR325C RPL38 hom Verified 1.0290213783622 0.151734814523101 no 728 0.174184192481123 562 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L38; homologous to mammalian ribosomal protein L38, no bacterial homolog cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YBR131W YBR131W CCZ1 hom Verified 1.02853438088536 0.15184926342441 no 729 0.148852085717604 559 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS Protein involved in vacuolar assembly, essential for autophagy and the cytoplasm-to-vacuole pathway autophagy|autophagic vacuole fusion|vacuolar transport|vesicle docking|protein targeting to vacuole guanyl-nucleotide exchange factor activity Mon1-Ccz1 complex|membrane
YIL103W YIL103W DPH1 hom Verified 1.02663517500812 0.152296142197062 no 730 0.154458800890796 550 NA Protein required, along with Dph2p, Kti11p, Jjj3p, and Dph5p, for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); may act in a complex with Dph2p and Kti11p peptidyl-diphthamide biosynthetic process from peptidyl-histidine molecular_function cytoplasm
YBL039C YBL039C URA7 hom Verified 1.02646233573887 0.152336854176183 no 731 0.157181983400451 572 NA FT KETONE METABOLISM|LIPID METABOLISM|AMINO ACID METABOLISM|NUCLEOTIDE METABOLISM Major CTP synthase isozyme (see also URA8); catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis; capable of forming cytoplasmic filaments termed cytoophidium, especially during conditions of glucose depletion; URA7 has a paralog, URA8, that arose from the whole genome duplication pyrimidine nucleobase biosynthetic process|CTP biosynthetic process|phospholipid biosynthetic process CTP synthase activity cytosol
YPL035C_d YPL035C YPL035C hom Dubious 1.02631666966465 0.152371171167337 no 732 0.155646714145261 563 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YPL034W; YPL035C is not an essential gene Unknown Unknown Unknown
YDR286C_p YDR286C YDR286C hom Uncharacterized 1.02625962269019 0.152384612074487 no 733 0.125680146826815 425 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY Putative protein of unknown function; predicted to have thiol-disulfide oxidoreductase active site biological_process molecular_function cellular_component
YPL171C YPL171C OYE3 hom Verified 1.02620888214793 0.152396567776704 no 734 0.154694892557498 550 NA FT OXIDATION-REDUCTION PROCESS Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN), homologous to Oye2p with different ligand binding and catalytic properties; has potential roles in oxidative stress response and programmed cell death apoptotic process NADPH dehydrogenase activity cellular_component
YJR044C YJR044C VPS55 hom Verified 1.02559584438877 0.152541063537418 no 735 0.155287014268861 529 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT Late endosomal protein involved in late endosome to vacuole trafficking; functional homolog of human obesity receptor gene-related protein (OB-RGRP) late endosome to vacuole transport via multivesicular body sorting pathway molecular_function Vps55/Vps68 complex|late endosome|integral to membrane
YJR113C YJR113C RSM7 hom Verified 1.02516456542591 0.152642772386536 no 736 0.179073181745443 614 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S7 ribosomal protein mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial small ribosomal subunit
YLR247C YLR247C IRC20 hom Verified 1.02515536893864 0.152644941690971 no 737 0.12474217306861 460 NA FT RESPONSE TO DNA DAMAGE NUCLEUS|MITOCHONDRION Putative helicase; localizes to the mitochondrion and the nucleus; YLR247C is not an essential gene; null mutant displays increased levels of spontaneous Rad52p foci double-strand break repair via synthesis-dependent strand annealing helicase activity mitochondrion|nucleus
YDR207C YDR207C UME6 hom Verified 1.02491647613789 0.1527012998524 no 738 0.235287398179002 813 NA FF|FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO NUTRIENT LEVELS NUCLEUS|CHROMOSOME Key transcriptional regulator of early meiotic genes, binds URS1 upstream regulatory sequence, couples metabolic responses to nutritional cues with initiation and progression of meiosis, forms complex with Ime1p, and also with Sin3p-Rpd3p spore germination|positive regulation of transcription from RNA polymerase II promoter during meiosis|negative regulation of transcription from RNA polymerase II promoter during meiosis|lipid particle organization|nitrogen catabolite repression of transcription from RNA polymerase II promoter|pseudohyphal growth|negative regulation of transcription from RNA polymerase II promoter during mitosis|Unknown RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|repressing transcription factor binding|transcription factor binding transcription factor activity Rpd3L-Expanded complex|Rpd3L complex
YNL079C YNL079C TPM1 hom Verified 1.02487795535695 0.152710388736828 no 739 0.159944848914102 606 NA FF|FT VESICLE-MEDIATED TRANSPORT|CELL DIVISION|MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION|RNA LOCALIZATION SITE OF POLARIZED GROWTH|CYTOSKELETON Major isoform of tropomyosin; binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; acetylated by the NatB complex and acetylated form binds actin most efficiently; TPM1 has a paralog, TPM2, that arose from the whole genome duplication vacuole inheritance|exocytosis|intracellular mRNA localization|filamentous growth|budding cell apical bud growth|mitochondrion inheritance|budding cell isotropic bud growth|actin polymerization or depolymerization|actin filament organization|pseudohyphal growth|vesicle-mediated transport|establishment of cell polarity|actin filament bundle assembly actin lateral binding cellular bud neck contractile ring|actin filament bundle
YIL157C YIL157C COA1 hom Verified 1.02324494171919 0.153096024378932 no 740 0.152142997933836 595 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial inner membrane protein required for assembly of the cytochrome c oxidase complex (complex IV); interacts with complex IV assembly factor Shy1p during the early stages of assembly mitochondrial respiratory chain complex IV assembly molecular_function integral to mitochondrial membrane|mitochondrion|integral to mitochondrial inner membrane
YKR013W YKR013W PRY2 hom Verified 1.01935600543987 0.154016992216494 no 741 0.18353365129654 641 NA Sterol binding protein involved in the export of acetylated sterols; secreted glycoprotein and member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis related 1 proteins); sterol export function is redundant with that of PRY1; may be involved in detoxification of hydrophobic compounds; PRY2 has a paralog, PRY1, that arose from the whole genome duplication biological_process molecular_function extracellular region|fungal-type vacuole
YMR124W_p YMR124W YMR124W hom Uncharacterized 1.01880482598062 0.154147817075422 no 742 0.137880299044811 497 NA Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene; predicted to have a role in organelle organization biological_process molecular_function cytoplasm
YDR078C YDR078C SHU2 hom Verified 1.0165348884745 0.154687371190174 no 743 0.154956455876719 561 NA FT RESPONSE TO DNA DAMAGE NUCLEUS Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function recombinational repair|maintenance of rDNA|error-free translesion synthesis molecular_function Shu complex
YGR134W YGR134W CAF130 hom Verified 1.01586950940596 0.154845765082322 no 744 0.139553572819092 515 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Part of the evolutionarily-conserved CCR4-NOT transcriptional regulatory complex involved in controlling mRNA initiation, elongation, and degradation regulation of transcription from RNA polymerase II promoter|positive regulation of transcription elongation from RNA polymerase II promoter molecular_function CCR4-NOT core complex
YLR265C YLR265C NEJ1 hom Verified 1.01554127471278 0.154923940998725 no 745 0.142310494289007 459 NA FT RESPONSE TO DNA DAMAGE ENDOMEMBRANE SYSTEM|NUCLEUS Protein involved in regulation of nonhomologous end joining; interacts with DNA ligase IV components Dnl4p and Lif1p; repressed by MAT heterozygosity; regulates cellular distribution of Lif1p double-strand break repair via nonhomologous end joining|double-strand break repair via single-strand annealing DNA end binding DNA ligase IV complex|nucleus
YOR125C YOR125C CAT5 hom Verified 1.01534160616233 0.15497150896472 no 746 0.142513889349066 517 NA FT KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|COFACTOR METABOLISM MITOCHONDRION Protein required for ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes; required for gluconeogenic gene activation ubiquinone biosynthetic process monooxygenase activity mitochondrion|mitochondrial inner membrane
YER040W YER040W GLN3 hom Verified 1.01523913533014 0.154995924811812 no 747 0.148905902403122 546 NA FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS NUCLEUS Transcriptional activator of genes regulated by nitrogen catabolite repression (NCR), localization and activity regulated by quality of nitrogen source nitrogen catabolite activation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity cytosol|nucleus
YBR068C YBR068C BAP2 hom Verified 1.01345000528458 0.155422632321552 no 748 0.141475676821309 526 NA FT PLASMA MEMBRANE High-affinity leucine permease; functions as a branched-chain amino acid permease involved in uptake of leucine, isoleucine and valine; contains 12 predicted transmembrane domains; BAP2 has a paralog, BAP3, that arose from the whole genome duplication amino acid transport|transmembrane transport amino acid transmembrane transporter activity integral to membrane|plasma membrane
YBR144C_d YBR144C YBR144C hom Dubious 1.01281013548291 0.155575429271928 no 749 0.129364019160658 475 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR144C is not an essential gene Unknown Unknown Unknown
YLR131C YLR131C ACE2 hom Verified 1.00596493118124 0.157216219894397 no 750 0.280447459869525 1002 NA FF|FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CELL DIVISION NUCLEUS Transcription factor required for septum destruction after cytokinesis; phosphorylation by Cbk1p blocks nuclear exit during M/G1 transition, causing localization to daughter cell nuclei, and also increases Ace2p activity; phosphorylation by Cdc28p and Pho85p prevents nuclear import during cell cycle phases other than cytokinesis; part of RAM network that regulates cellular polarity and morphogenesis; ACE2 has a paralog, SWI5, that arose from the whole genome duplication Unknown|regulation of transcription involved in G1 phase of mitotic cell cycle RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity|core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding cytosol|nucleus
YGL243W YGL243W TAD1 hom Verified 1.00580707579203 0.157254191455841 no 751 0.13697201378084 454 NA FT RNA PROCESSING NUCLEUS tRNA-specific adenosine deaminase, deaminates adenosine-37 to inosine in tRNA-Ala tRNA modification tRNA-specific adenosine-37 deaminase activity nucleus
YDL059C YDL059C RAD59 hom Verified 1.00405244316298 0.157676668175186 no 752 0.176799492455103 638 NA FT RESPONSE TO DNA DAMAGE NUCLEUS Protein involved DNA double-strand break repair; repairs breaks in DNA during vegetative growth via recombination and single-strand annealing; anneals complementary single-stranded DNA; forms nuclear foci upon DNA replication stress; required for loading of Rad52p to DSBs; paralog of Rad52p DNA strand renaturation|telomere maintenance via recombination|double-strand break repair via break-induced replication|double-strand break repair via single-strand annealing protein binding nucleus
YJL063C YJL063C MRPL8 hom Verified 1.00332759728548 0.157851412462176 no 753 0.180654914039905 656 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit mitochondrial genome maintenance|mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YOL062C YOL062C APM4 hom Verified 1.00141455673721 0.158313214700972 no 754 0.136298232344287 526 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|PLASMA MEMBRANE Mu2-like subunit of the clathrin associated protein complex (AP-2); involved in vesicle transport intracellular protein transport|vesicle-mediated transport molecular_function AP-2 adaptor complex
YMR243C YMR243C ZRC1 hom Verified 1.00124736960166 0.158353615250018 no 755 0.157588987960886 576 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION Vacuolar membrane zinc transporter; transports zinc from cytosol to vacuole for storage; also has role in resistance to zinc shock resulting from sudden influx of zinc into cytoplasm; human ortholog SLC30A10 functions as a Mn transporter and mutations in SLC30A10 cause neurotoxic accumulation of Mn in liver and brain; ZRC1 has a paralog, COT1, that arose from the whole genome duplication cobalt ion transport|cellular zinc ion homeostasis|zinc ion transport|glutathione metabolic process zinc ion transmembrane transporter activity|inorganic cation transmembrane transporter activity integral to membrane|fungal-type vacuole
YGL031C YGL031C RPL24A hom Verified 1.00034721707594 0.158571252149984 no 756 0.168322019566989 611 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L24A; not essential for translation but may be required for normal translation rate; homologous to mammalian ribosomal protein L24, no bacterial homolog; RPL24A has a paralog, RPL24B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome|RNA binding cytosolic large ribosomal subunit
YOR352W YOR352W TFB6 hom Verified 0.997501101723766 0.159260669649269 no 757 0.154988774653844 568 NA FT NUCLEUS Subunit of TFIIH complex; facilities dissociation of the Ssl2p helices from TFIIH; expression levels regulated by Arg5,6p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus biological_process molecular_function nucleus|holo TFIIH complex|cytoplasm
YLR053C_p YLR053C YLR053C hom Uncharacterized 0.996985644607791 0.159385739001949 no 758 0.133479349362787 485 NA Putative protein of unknown function biological_process molecular_function cellular_component
YLR061W YLR061W RPL22A hom Verified 0.996831610021541 0.159423126083229 no 759 0.170629049269241 572 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L22A; required for the oxidative stress response in yeast; homologous to mammalian ribosomal protein L22, no bacterial homolog; RPL22A has a paralog, RPL22B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YNR021W_p YNR021W YNR021W hom Uncharacterized 0.996288937486451 0.159554888621361 no 760 0.14500213685325 471 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YNR021W is not an essential gene biological_process molecular_function endoplasmic reticulum
YPR130C_d YPR130C YPR130C hom Dubious 0.99485608393829 0.159903132270897 no 761 0.164657186647685 586 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YOR197W YOR197W MCA1 hom Verified 0.991885076071441 0.160626794993195 no 762 0.141172796035166 503 NA FT PROTEOLYSIS NUCLEUS Ca2+-dependent cysteine protease; may cleave specific substrates during the stress response; regulates apoptosis upon H2O2 treatment; required for clearance of insoluble protein aggregates during normal growth; implicated in cell cycle dynamics; undergoes autocatalytic processing; similar to mammalian metacaspases, but exists as a monomer due to an extra pair of anti-parallel beta-strands that form a continuous beta-sheet, blocking potential dimerization misfolded or incompletely synthesized protein catabolic process|apoptotic process cysteine-type peptidase activity nucleus
YMR153C-A_d YMR153C-A YMR153C-A hom Dubious 0.99183236519874 0.160639653316804 no 763 0.114651284437832 448 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NUP53 Unknown Unknown Unknown
YMR291W YMR291W TDA1 hom Verified 0.990506026233803 0.1609634225588 no 764 0.15211863209284 515 NA FT PROTEIN PHOSPHORYLATION NUCLEUS Protein kinase of unknown cellular role; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; null mutant is sensitive to expression of the top1-T722A allele; not an essential gene; relocalizes from nucleus to cytoplasm upon DNA replication stress protein phosphorylation protein kinase activity nucleus|cytoplasm
YDR026C YDR026C NSI1 hom Verified 0.989745291005824 0.161149315779623 no 765 0.133346041035897 433 NA FT CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS|CHROMOSOME RNA polymerase I termination factor; binds to rDNA terminator element, required for efficient Pol I termination; required for rDNA silencing at NTS1; facilities association of Sir2p with NTS1, contributes to rDNA stability and cell longevity; interacts physically with Fob1p and RENT subunits, Sir2p and Net1p; may interact with ribosomes, based on co-purification experiments; Myb-like DNA-binding protein; NSI1 has a paralog, REB1, that arose from the whole genome duplication termination of RNA polymerase I transcription|chromatin silencing at rDNA|Unknown DNA binding ribosome|nucleolus|rDNA heterochromatin
YIL145C YIL145C PAN6 hom Verified 0.989346160485276 0.161246903295833 no 766 0.123114946060598 421 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM NUCLEUS Pantothenate synthase, also known as pantoate-beta-alanine ligase, required for pantothenic acid biosynthesis, deletion causes pantothenic acid auxotrophy, homologous to E. coli panC pantothenate biosynthetic process pantoate-beta-alanine ligase activity nucleus|cytoplasm
YGR154C YGR154C GTO1 hom Verified 0.987704476573656 0.161648700735808 no 767 0.155054581053452 531 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS Omega-class glutathione transferase; induced under oxidative stress; putative peroxisomal localization glutathione metabolic process glutathione transferase activity peroxisome
YPL249C YPL249C GYP5 hom Verified 0.986105828844126 0.162040591820351 no 768 0.14478537139427 474 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING|NUCLEOTIDE METABOLISM GOLGI APPARATUS|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE GTPase-activating protein (GAP) for yeast Rab family members; involved in ER to Golgi trafficking; exhibits GAP activity toward Ypt1p that is stimulated by Gyl1p, also acts on Sec4p; interacts with Gyl1p, Rvs161p and Rvs167p; involved in recruiting Rvs167p to the bud tip during polarized growth; relocalizes from bud neck to cytoplasm upon DNA replication stress vesicle-mediated transport|ER to Golgi vesicle-mediated transport Rab GTPase activator activity cytosol|incipient cellular bud site|plasma membrane|cellular bud neck|Golgi-associated vesicle|cellular bud tip
YLR024C YLR024C UBR2 hom Verified 0.985994337699441 0.162067945724088 no 769 0.145511727327869 478 NA Cytoplasmic ubiquitin-protein ligase (E3); required for ubiquitylation of Rpn4p; mediates formation of a Mub1p-Ubr2p-Rad6p complex protein monoubiquitination ubiquitin-protein ligase activity cytoplasm
YKL194C YKL194C MST1 hom Verified 0.985051229571567 0.16229945381595 no 770 0.205756118314003 687 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial threonyl-tRNA synthetase; aminoacylates both the canonical threonine tRNA tT(UGU)Q1 and the unusual threonine tRNA tT(XXX)Q2 in vitro mitochondrial threonyl-tRNA aminoacylation threonine-tRNA ligase activity mitochondrion
YER019W YER019W ISC1 hom Verified 0.983837658087082 0.162597670086843 no 771 0.172505737566781 640 NA FT LIPID METABOLISM ENDOPLASMIC RETICULUM|MITOCHONDRION Mitochondrial membrane localized inositol phosphosphingolipid phospholipase C, hydrolyzes complex sphingolipids to produce ceramide; activated by phosphatidylserine, cardiolipin, and phosphatidylglycerol; mediates Na+ and Li+ halotolerance response to salt stress|ceramide biosynthetic process|sphingolipid catabolic process inositol phosphosphingolipid phospholipase activity mitochondrion|endoplasmic reticulum|integral to mitochondrial outer membrane
YGL230C_p YGL230C YGL230C hom Uncharacterized 0.983379684590146 0.162710302526747 no 772 0.139740363324782 476 NA Putative protein of unknown function; non-essential gene biological_process molecular_function cellular_component
YJL101C YJL101C GSH1 hom Verified 0.983282408595776 0.162734232785966 no 773 0.146206295388995 489 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|RESPONSE TO OXIDATIVE STRESS Gamma glutamylcysteine synthetase; catalyzes the first step in glutathione (GSH) biosynthesis; expression induced by oxidants, cadmium, and mercury; protein abundance increases in response to DNA replication stress response to cadmium ion|response to hydrogen peroxide|glutathione biosynthetic process glutamate-cysteine ligase activity intracellular
YHR048W_p YHR048W YHK8 hom Uncharacterized 0.981700041219006 0.163123822552187 no 774 0.184052498738111 620 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS Presumed antiporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; expression of gene is up-regulated in cells exhibiting reduced susceptibility to azoles drug transport molecular_function integral to membrane
YCL042W_p YCL042W YCL042W hom Uncharacterized 0.980505480540852 0.163418332833716 no 775 0.186740046464008 657 NA Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm biological_process molecular_function cytoplasm
YIR026C YIR026C YVH1 hom Verified 0.978679038118161 0.163869296280224 no 776 0.168297989761919 568 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RIBOSOME BIOGENESIS|SIGNALING|CELL WALL ORG/BIOGENESIS NUCLEUS Protein phosphatase involved in vegetative growth at low temperatures, sporulation, and glycogen accumulation; mutants are defective in 60S ribosome assembly; member of the dual-specificity family of protein phosphatases meiosis|ascospore wall assembly|ribosomal large subunit assembly|cAMP-mediated signaling|protein dephosphorylation protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity nucleus|preribosome, large subunit precursor|cytoplasm
YLR065C YLR065C ENV10 hom Verified 0.976552996838541 0.164395249301152 no 777 0.201201199437622 754 NA FF|FT VACUOLAR PROTEIN PROCESSING Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing; YLR065C is not an essential gene vacuolar protein processing molecular_function integral to membrane
YHR009C_p YHR009C TDA3 hom Uncharacterized 0.976189761167535 0.164485218087039 no 778 0.173532647188945 604 NA FT VESICLE-MEDIATED TRANSPORT|OXIDATION-REDUCTION PROCESS Putative oxidoreductase involved in late endosome to Golgi transport; physical and genetical interactions with Btn2p; null mutant is viable, has extended S phase, and sensitive to expression of top1-T722A allele; similar to human FOXRED1 retrograde transport, endosome to Golgi molecular_function late endosome|cytoplasm
YGL234W YGL234W ADE5,7 hom Verified 0.975931018122806 0.164549324857931 no 779 0.158838983021065 575 NA FT NUCLEOTIDE METABOLISM Bifunctional enzyme of the 'de novo' purine nucleotide biosynthetic pathway, contains aminoimidazole ribotide synthetase and glycinamide ribotide synthetase activities purine nucleobase metabolic process|purine nucleotide biosynthetic process|'de novo' IMP biosynthetic process phosphoribosylamine-glycine ligase activity|phosphoribosylformylglycinamidine cyclo-ligase activity cytoplasm
YLR165C YLR165C PUS5 hom Verified 0.973396534808973 0.16517813023293 no 780 0.171977799009788 611 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS MITOCHONDRION Pseudouridine synthase, catalyzes only the formation of pseudouridine (Psi)-2819 in mitochondrial 21S rRNA; not essential for viability rRNA modification|pseudouridine synthesis pseudouridylate synthase activity mitochondrion
YNR013C YNR013C PHO91 hom Verified 0.971611342950866 0.165621968696745 no 781 0.179893068810634 584 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS Low-affinity phosphate transporter of the vacuolar membrane; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth phosphate ion transport|polyphosphate metabolic process phosphate ion transmembrane transporter activity fungal-type vacuole membrane|integral to membrane|membrane
YMR132C_p YMR132C JLP2 hom Uncharacterized 0.971163699645286 0.165733383625673 no 782 0.130355357948221 447 NA Protein of unknown function, contains sequence that closely resembles a J domain (typified by the E. coli DnaJ protein) biological_process molecular_function cytoplasm
YLR015W YLR015W BRE2 hom Verified 0.968845537123939 0.166311131233074 no 783 0.201842653088944 703 NA FT CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS|CHROMOSOME Subunit of COMPASS (Set1C) complex, which methylates Lys4 of histone H3 and functions in silencing at telomeres; has a C-terminal Sdc1 Dpy-30 Interaction (SDI) domain that mediates binding to Sdc1p; similar to trithorax-group protein ASH2L histone H3-K4 methylation|telomere maintenance|histone H3-K4 trimethylation|chromatin silencing at telomere histone methyltransferase activity (H3-K4 specific) Set1C/COMPASS complex
YDL067C YDL067C COX9 hom Verified 0.967749477163099 0.166584750774711 no 784 0.170572100926767 616 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Subunit VIIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain mitochondrial electron transport, cytochrome c to oxygen cytochrome-c oxidase activity mitochondrion|integral to membrane|mitochondrial respiratory chain complex IV
YGL263W YGL263W COS12 hom Verified 0.966938794360587 0.166787315807623 no 785 0.135282874586149 460 NA Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins biological_process molecular_function integral to membrane
YDR415C_p YDR415C YDR415C hom Uncharacterized 0.965274084854992 0.16720377419604 no 786 0.138398296140804 477 NA FT PROTEOLYSIS Putative aminopeptidase biological_process molecular_function cellular_component
YPR057W YPR057W BRR1 hom Verified 0.965097517145786 0.167247985215889 no 787 0.127902918545417 504 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING NUCLEUS snRNP protein component of spliceosomal snRNPs, required for pre-mRNA splicing and snRNP biogenesis; in null mutant newly-synthesized snRNAs are destabilized and 3'-end processing is slowed spliceosomal complex assembly RNA binding small nuclear ribonucleoprotein complex
YDR195W YDR195W REF2 hom Verified 0.964521936566503 0.167392157902809 no 788 0.191912164894968 657 NA FT TRANSCRIPTION FROM RNA POL II|RNA PROCESSING NUCLEUS RNA-binding protein involved in the cleavage step of mRNA 3'-end formation prior to polyadenylation, and in snoRNA maturation; part of holo-CPF subcomplex APT, which associates with 3'-ends of snoRNA- and mRNA-encoding genes mRNA 3'-end processing|termination of RNA polymerase II transcription, poly(A)-coupled|snoRNA 3'-end processing|Unknown chromatin binding|RNA binding mRNA cleavage and polyadenylation specificity factor complex|nucleus
YJL068C YJL068C YJL068C hom Verified 0.964023751023461 0.16751700914816 no 789 0.14838938487111 521 NA Non-essential intracellular esterase that can function as an S-formylglutathione hydrolase; may be involved in the detoxification of formaldehyde, which can be metabolized to S-formylglutathione; similar to human esterase D formaldehyde catabolic process S-formylglutathione hydrolase activity cytosol
YHR156C YHR156C LIN1 hom Verified 0.963886407028155 0.167551439739864 no 790 0.169789271494899 588 NA FT NUCLEUS|CHROMOSOME Non-essential component of U5 snRNP; nuclear protein; physically interacts with Irr1p of cohesin complex; may link together proteins involved in chromosome segregation, mRNA splicing and DNA replication biological_process protein binding chromatin|nucleus|U4/U6 x U5 tri-snRNP complex|U5 snRNP
YDR179W-A_p YDR179W-A YDR179W-A hom Uncharacterized 0.963640047565019 0.167613210702211 no 791 0.168684322675798 552 NA Putative protein of unknown function biological_process molecular_function cellular_component
YOL016C YOL016C CMK2 hom Verified 0.963378570841241 0.167678788136106 no 792 0.174212145108037 582 NA FT SIGNALING|PROTEIN PHOSPHORYLATION Calmodulin-dependent protein kinase; may play a role in stress response, many CA++/calmodulan dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to mammalian Cam Kinase II; CMK2 has a paralog, CMK1, that arose from the whole genome duplication signal transduction|protein phosphorylation protein kinase activity|calmodulin-dependent protein kinase activity cytoplasm
YPL226W YPL226W NEW1 hom Verified 0.962848516961165 0.167811774457813 no 793 0.152842420358202 615 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|NUCLEOTIDE METABOLISM|RNA LOCALIZATION NUCLEUS|MITOCHONDRION ATP binding cassette protein that cosediments with polysomes and is required for biogenesis of the small ribosomal subunit; Asn/Gln-rich rich region supports [NU+] prion formation and susceptibility to [PSI+] prion induction ribosomal small subunit biogenesis|poly(A)+ mRNA export from nucleus ATPase activity|ATP binding mitochondrion|polysome|cytoplasm
YNL117W YNL117W MLS1 hom Verified 0.962736698806114 0.167839837419011 no 794 0.178903177610087 599 NA FT KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM Malate synthase, enzyme of the glyoxylate cycle; involved in utilization of non-fermentable carbon sources; expression is subject to carbon catabolite repression; localizes in peroxisomes during growth on oleic acid, otherwise cytosolic glyoxylate cycle malate synthase activity peroxisomal matrix|cytoplasm
YJL149W YJL149W DAS1 hom Verified 0.961974965761351 0.168031089671507 no 795 0.181890792549472 652 NA FT PROTEOLYSIS UBIQUITIN LIGASE COMPLEX Putative SCF ubiquitin ligase F-box protein; interacts physically with both Cdc53p and Skp1 and genetically with CDC34; similar to putative F-box protein YDR131C SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ubiquitin-protein ligase activity|protein binding, bridging SCF ubiquitin ligase complex
YNL100W YNL100W AIM37 hom Verified 0.961654353177291 0.168111629452637 no 796 0.185258219984925 692 NA FT MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial inner membrane protein; component of the mitochondrial inner membrane organizing system (MitOS, MICOS, or MINOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture cristae formation molecular_function mitochondrion|mitochondrial crista junction|integral to mitochondrial inner membrane
YFL019C_d YFL019C YFL019C hom Dubious 0.961566172189765 0.168133785394074 no 797 0.141974752974395 535 NA Dubious open reading frame unlikely to encode a protein; YFL019C is not an essential gene Unknown Unknown Unknown
YPL156C YPL156C PRM4 hom Verified 0.960418299851419 0.168422365811663 no 798 0.140570237643666 542 NA Pheromone-regulated protein proposed to be involved in mating; predicted to have 1 transmembrane segment; transcriptionally regulated by Ste12p during mating and by Cat8p during the diauxic shift biological_process molecular_function integral to membrane
YER066C-A_d YER066C-A YER066C-A hom Dubious 0.958090741411621 0.169008501872487 no 799 0.149139516537032 485 NA Dubious open reading frame unlikely to encode a protein, partially overlaps uncharacterized ORF YER067W Unknown Unknown Unknown
YCR019W YCR019W MAK32 hom Verified 0.954464128263056 0.169924379378376 no 800 0.165795151057099 582 NA Protein necessary for structural stability of L-A double-stranded RNA-containing particles interspecies interaction between organisms molecular_function cellular_component
YPL032C YPL032C SVL3 hom Verified 0.952803425314318 0.170344839240063 no 801 0.207492693049813 707 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|OXIDATION-REDUCTION PROCESS SITE OF POLARIZED GROWTH Protein of unknown function; mutant phenotype suggests a potential role in vacuolar function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; relocalizes from bud neck to cytoplasm upon DNA replication stress endocytosis molecular_function cellular bud|cellular bud neck|cytoplasm
YPL101W YPL101W ELP4 hom Verified 0.952576841684639 0.170402257727031 no 802 0.202127079376389 676 NA FT TRANSCRIPTION FROM RNA POL II|RNA PROCESSING NUCLEUS Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity regulation of transcription from RNA polymerase II promoter|tRNA wobble uridine modification ATPase activity|tRNA binding Elongator holoenzyme complex|cytoplasm
YCR107W YCR107W AAD3 hom Verified 0.951942213309964 0.170563144678284 no 803 0.190514028519541 644 NA FT OXIDATION-REDUCTION PROCESS Putative aryl-alcohol dehydrogenase; similar to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role cellular aldehyde metabolic process aryl-alcohol dehydrogenase (NAD+) activity cellular_component
YOR096W YOR096W RPS7A hom Verified 0.951915297922696 0.170569970245385 no 804 0.207098603842581 681 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION NUCLEUS RIBOSOME Protein component of the small (40S) ribosomal subunit; interacts with Kti11p; deletion causes hypersensitivity to zymocin; homologous to mammalian ribosomal protein S7, no bacterial homolog; RPS7A has a paralog, RPS7B, that arose from the whole genome duplication cytoplasmic translation|ribosome biogenesis structural constituent of ribosome small-subunit processome|cytosolic small ribosomal subunit|90S preribosome
YBR277C_d YBR277C YBR277C hom Dubious 0.949851732046724 0.171093797777694 no 805 0.175880205434947 626 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR278W Unknown Unknown Unknown
YOR338W_p YOR338W YOR338W hom Uncharacterized 0.94962750939397 0.171150777664169 no 806 0.148748101892323 553 NA FT TRANSCRIPTION FROM RNA POL II Putative protein of unknown function; YOR338W transcription is regulated by Azf1p and its transcript is a specific target of the G protein effector Scp160p; identified as being required for sporulation in a high-throughput mutant screen; YOR338W has a paralog, FUN19, that arose from the whole genome duplication ascospore formation|positive regulation of transcription from RNA polymerase II promoter molecular_function cellular_component
YMR265C_p YMR265C YMR265C hom Uncharacterized 0.948613849034547 0.171408522376374 no 807 0.168877169685503 587 NA Putative protein of unknown function biological_process molecular_function cellular_component
YPL018W YPL018W CTF19 hom Verified 0.948554845349202 0.171423532955691 no 808 0.193953286515464 668 NA FT PROTEIN LOCALIZATION|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME KINETOCHORE Outer kinetochore protein, needed for accurate chromosome segregation; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) that functions as a platform for kinetochore assembly; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-P and fission yeast fta2 attachment of spindle microtubules to kinetochore|chromosome segregation|establishment of mitotic sister chromatid cohesion molecular_function COMA complex|condensed nuclear chromosome kinetochore|nucleus
YOR175C YOR175C ALE1 hom Verified 0.947269284488021 0.171750789102669 no 809 0.176290876965453 605 NA FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Broad-specificity lysophospholipid acyltransferase, part of MBOAT family of membrane-bound O-acyltransferases; key component of Lands cycle; may have role in fatty acid exchange at sn-2 position of mature glycerophospholipids glycerophospholipid biosynthetic process 1-acylglycerophosphocholine O-acyltransferase activity|O-acyltransferase activity|1-acylglycerol-3-phosphate O-acyltransferase activity integral to membrane|ribosome|endoplasmic reticulum
YDR312W YDR312W SSF2 hom Verified 0.94633230640376 0.171989560233748 no 810 0.135851302265669 469 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS NUCLEUS Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication conjugation with cellular fusion|ribosomal large subunit assembly rRNA binding nucleolus
YBR171W YBR171W SEC66 hom Verified 0.944928710465196 0.172347636385793 no 811 0.289039011170444 1007 NA FF|FT PROTEIN LOCALIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER posttranslational protein targeting to membrane, translocation|filamentous growth protein transporter activity integral to membrane|Sec62/Sec63 complex|endoplasmic reticulum membrane
YLR178C YLR178C TFS1 hom Verified 0.944559186929521 0.172441985825774 no 812 0.135230083334396 454 NA FT SIGNALING|PROTEOLYSIS Protein that interacts with and inhibits carboxypeptidase Y and Ira2p; phosphatidylethanolamine-binding protein (PEBP) family member; targets to vacuolar membranes during stationary phase; acetylated by NatB N-terminal acetyltransferase; protein abundance increases in response to DNA replication stress regulation of Ras protein signal transduction|regulation of proteolysis lipid binding|peptidase inhibitor activity|phospholipid binding fungal-type vacuole lumen|fungal-type vacuole membrane|cytoplasm
YMR052W YMR052W FAR3 hom Verified 0.94398831973442 0.172587808540957 no 813 0.190777658035876 684 NA FT CELL CYCLE|SIGNALING ENDOPLASMIC RETICULUM Protein of unknown function; involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far7p, Far8p, Far9p, Far10p, and Far11p; localizes to the endoplasmic reticulum; protein abundance increases in response to DNA replication stress re-entry into mitotic cell cycle after pheromone arrest molecular_function endoplasmic reticulum
YDR442W_d YDR442W YDR442W hom Dubious 0.941843910685384 0.173136280051212 no 814 0.207111629763666 695 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YMR001C-A_p YMR001C-A YMR001C-A hom Uncharacterized 0.941339459452214 0.173265463720716 no 815 0.1617793452317 629 NA Putative protein of unknown function biological_process molecular_function cellular_component
YLR154C YLR154C RNH203 hom Verified 0.939920845965159 0.173629081831633 no 816 0.153562451853457 522 NA FT NUCLEUS Ribonuclease H2 subunit, required for RNase H2 activity; related to human AGS3 that causes Aicardi-Goutieres syndrome RNA catabolic process|DNA replication, removal of RNA primer ribonuclease H activity ribonuclease H2 complex|nucleus|cytoplasm
YMR282C YMR282C AEP2 hom Verified 0.939345031247895 0.17377681273127 no 817 0.210903930266121 710 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial protein, likely involved in translation of the mitochondrial OLI1 mRNA; exhibits genetic interaction with the OLI1 mRNA 5'-untranslated leader mitochondrial translational initiation molecular_function mitochondrion
YOR193W YOR193W PEX27 hom Verified 0.938591494114388 0.173970260793279 no 818 0.169093417590905 551 NA FT PEROXISOME ORGANIZATION Peripheral peroxisomal membrane protein involved in controlling peroxisome size and number, interacts with homologous protein Pex25p peroxisome organization molecular_function peroxisomal membrane
YDR112W_d YDR112W IRC2 hom Dubious 0.937831102047579 0.174165607394243 no 819 0.168783325331082 601 NA Dubious open reading frame, unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR111C; null mutant displays increased levels of spontaneous Rad52p foci Unknown Unknown Unknown
YJL198W YJL198W PHO90 hom Verified 0.937456667055682 0.174261851876129 no 820 0.179180393190171 597 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS Low-affinity phosphate transporter; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth; PHO90 has a paralog, PHO87, that arose from the whole genome duplication phosphate ion transport phosphate ion transmembrane transporter activity integral to membrane|membrane
YDR338C_p YDR338C YDR338C hom Uncharacterized 0.936143778470121 0.174599582681773 no 821 0.198511437779411 660 NA Putative protein of unknown function, member of the multi-drug and toxin extrusion (MATE) family of the multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter superfamily transmembrane transport antiporter activity integral to membrane
YMR300C YMR300C ADE4 hom Verified 0.934951988829918 0.174906521332798 no 822 0.184985186590127 643 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEOTIDE METABOLISM Phosphoribosylpyrophosphate amidotransferase (PRPPAT; amidophosphoribosyltransferase), catalyzes first step of the 'de novo' purine nucleotide biosynthetic pathway 'de novo' IMP biosynthetic process amidophosphoribosyltransferase activity cytoplasm
YPR184W YPR184W GDB1 hom Verified 0.933471869093959 0.175288194155765 no 823 0.177205543278705 664 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY NUCLEUS|MITOCHONDRION Glycogen debranching enzyme; contains glucanotranferase and alpha-1,6-amyloglucosidase activities; required for glycogen degradation; phosphorylated in mitochondria; activity is inhibited by Igd1p; protein abundance increases in response to DNA replication stress glycogen catabolic process 4-alpha-glucanotransferase activity|amylo-alpha-1,6-glucosidase activity mitochondrion|cytoplasm
YDR370C YDR370C DXO1 hom Verified 0.932452088567471 0.175551468111607 no 824 0.169779948704057 563 NA Protein with decapping and 5′-3′ exoRNase activity; similar to Rai1p biological_process molecular_function cytoplasm
YPL246C YPL246C RBD2 hom Verified 0.928166188936363 0.176660685039439 no 825 0.160193524918534 560 NA FT PROTEOLYSIS ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Possible rhomboid protease, has similarity to eukaryotic rhomboid proteases including Pcp1p biological_process molecular_function COPI-coated vesicle|integral to membrane|Golgi apparatus
YMR075W YMR075W RCO1 hom Verified 0.928113265872291 0.176674409491002 no 826 0.182583852190924 656 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION NUCLEUS|CHROMOSOME Essential subunit of the histone deacetylase Rpd3S complex; interacts with Eaf3p regulation of DNA-dependent DNA replication initiation|negative regulation of antisense RNA transcription|transcription elongation from RNA polymerase II promoter|histone deacetylation molecular_function Rpd3S complex|histone deacetylase complex|nucleus|Rpd3L complex
YOR300W_d YOR300W YOR300W hom Dubious 0.925455801890132 0.177364431984276 no 827 0.155114149924071 496 NA Dubious open reading frame, unlikely to encode a protein; overlaps with verified gene BUD7/YOR299W; mutation affects bipolar budding and bud site selection, though phenotype could be due to the mutation's effects on BUD7 Unknown Unknown Unknown
YGR223C YGR223C HSV2 hom Verified 0.925001874272157 0.177482466255655 no 828 0.184286353174072 639 NA FT MEMBRANE ORGANIZATION|RESPONSE TO NUTRIENT LEVELS Phosphatidylinositol 3,5-bisphosphate-binding protein, plays a role in micronucleophagy; belongs to the PROPPIN family of proteins; predicted to fold as a seven-bladed beta-propeller; displays punctate cytoplasmic localization piecemeal microautophagy of nucleus phosphatidylinositol binding endosome|fungal-type vacuole|extrinsic to membrane|cytoplasm
YOR008C-A_p YOR008C-A YOR008C-A hom Uncharacterized 0.923967454893509 0.177751630313527 no 829 0.161079971773264 516 NA Putative protein of unknown function, includes a potential transmembrane domain; deletion results in slightly lengthened telomeres biological_process molecular_function cellular_component
YDR309C YDR309C GIC2 hom Verified 0.92297485861685 0.17801015365459 no 830 0.159427051733958 552 NA FT CELL CYCLE|SIGNALING|CELL DIVISION SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON Redundant rho-like GTPase Cdc42p effector; homolog of Gic1p; involved in initiation of budding and cellular polarization; interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain and with PI(4,5)P2 via a polybasic region regulation of exit from mitosis|establishment of cell polarity|axial cellular bud site selection|Rho protein signal transduction Rho GTPase binding|Rho GTPase activator activity|phosphatidylinositol-4,5-bisphosphate binding incipient cellular bud site|actin cap|plasma membrane|mating projection tip|cellular bud tip
YGL256W YGL256W ADH4 hom Verified 0.921100084816275 0.178499087984923 no 831 0.160650799662971 596 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Alcohol dehydrogenase isoenzyme type IV, dimeric enzyme demonstrated to be zinc-dependent despite sequence similarity to iron-activated alcohol dehydrogenases; transcription is induced in response to zinc deficiency fermentation|amino acid catabolic process to alcohol via Ehrlich pathway alcohol dehydrogenase (NAD) activity mitochondrion
YGL110C YGL110C CUE3 hom Verified 0.920256209133612 0.178719443567374 no 832 0.151978180207467 535 NA Protein of unknown function; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination biological_process ubiquitin binding cytoplasm
YGL242C_p YGL242C YGL242C hom Uncharacterized 0.91978159931848 0.178843450453573 no 833 0.201613868853446 655 NA Putative protein of unknown function; deletion mutant is viable biological_process molecular_function cellular_component
YMR052C-A_d YMR052C-A YMR052C-A hom Dubious 0.919325409855757 0.178962695471823 no 834 0.178323541239524 656 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YER105C YER105C NUP157 hom Verified 0.918301058905224 0.179230636537506 no 835 0.134927112615385 486 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS NUCLEAR PORE Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC assembly and tethering of DNA to the nuclear periphery; both Nup170p and NUP157p are similar to human Nup155p; NUP157 has a paralog, NUP170, that arose from the whole genome duplication nucleocytoplasmic transport|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|mitotic cell cycle spindle assembly checkpoint|nuclear pore complex assembly|transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery structural constituent of nuclear pore integral to membrane|nuclear pore|nuclear pore inner ring
YPR133W-A YPR133W-A TOM5 hom Verified 0.917992079727044 0.179311506203334 no 836 0.172115328818965 570 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import of all mitochondrially directed proteins; involved in transfer of precursors from the Tom70p and Tom20p receptors to the Tom40p pore mitochondrial outer membrane translocase complex assembly|protein targeting to mitochondrion protein channel activity mitochondrial outer membrane|mitochondrion|integral to membrane|integral to mitochondrial outer membrane|mitochondrial outer membrane translocase complex
YJL055W_p YJL055W YJL055W hom Uncharacterized 0.916374657718135 0.179735211259834 no 837 0.182382027468119 645 NA FT NUCLEUS Putative protein of unknown function, proposed to be involved in the metabolism of purine and pyrimidine base analogues; deletion mutants are sensitive to HAP and AHA; overexpression confers resistance to 5-FOA and 5-FU response to chemical stimulus|response to purine-containing compound molecular_function nucleus|cytoplasm
YIL002W-A_p YIL002W-A YIL002W-A hom Uncharacterized 0.915466034182636 0.179973512902469 no 838 0.168305785867812 599 NA Putative protein of unknown function; identified by expression profiling and mass spectrometry biological_process molecular_function cellular_component
YLR404W YLR404W FLD1 hom Verified 0.914754071388033 0.180160375563545 no 839 0.183154970959012 607 NA FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Seipin protein involved in lipid droplet morphology, number, and size; proposed to be involved in lipid metabolism; related to the human BSCL2 which is associated with lipodystrophy lipid particle organization molecular_function integral to membrane|endoplasmic reticulum|cortical endoplasmic reticulum
YEL036C YEL036C ANP1 hom Verified 0.914702820128691 0.180173831731599 no 840 0.223093091645687 759 NA FT CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS Subunit of the alpha-1,6 mannosyltransferase complex; type II membrane protein; has a role in retention of glycosyltransferases in the Golgi; involved in osmotic sensitivity and resistance to aminonitrophenyl propanediol protein N-linked glycosylation alpha-1,6-mannosyltransferase activity|mannosyltransferase activity alpha-1,6-mannosyltransferase complex|Golgi cis cisterna
YMR153W YMR153W NUP53 hom Verified 0.913985613045105 0.180362202728962 no 841 0.168286353501583 610 NA FT PROTEIN LOCALIZATION|CELL CYCLE|CELL DIVISION|RNA LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS NUCLEAR PORE FG-nucleoporin component of central core of nuclear pore complex (NPC); also part of the NPC nuclear basket; contributes directly to nucleocytoplasmic transport; involved in regulation of transcription and mitosis; induces membrane tubulation, which may contribute to nuclear pore assembly; NUP53 has a paralog, ASM4, that arose from the whole genome duplication positive regulation of transcription, DNA-dependent|NLS-bearing substrate import into nucleus|regulation of protein desumoylation|nuclear pore organization|protein import into nucleus|regulation of mitosis|mitotic cell cycle spindle assembly checkpoint nucleocytoplasmic transporter activity|phospholipid binding|single-stranded DNA binding nuclear pore central transport channel|nuclear pore nuclear basket|integral to membrane|nuclear pore
YDR110W YDR110W FOB1 hom Verified 0.913493127412336 0.180491623247328 no 842 0.171712708928191 552 NA FT PROTEIN LOCALIZATION|CELL CYCLE|CHROMATIN ORGANIZATION|CHROMOSOME SEGREGATION|GENE SILENCING NUCLEUS|CHROMOSOME Nucleolar protein that binds the rDNA replication fork barrier (RFB) site; required for replication fork blocking, recombinational hotspot activity, condensin recruitment to RFB and rDNA repeat segregation; related to retroviral integrases extrachromosomal circular DNA accumulation involved in cell aging|negative regulation of DNA replication|rDNA condensation|chromatin silencing at rDNA|replicative cell aging|protein localization to nucleolar rDNA repeats|DNA recombination rDNA spacer replication fork barrier binding nucleolus|rDNA heterochromatin
YDR205W YDR205W MSC2 hom Verified 0.913297382991021 0.18054307918467 no 843 0.187879499068866 653 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids cellular zinc ion homeostasis|zinc ion transport|transmembrane transport zinc ion transmembrane transporter activity|metal ion transmembrane transporter activity integral to membrane|endoplasmic reticulum
YIR027C YIR027C DAL1 hom Verified 0.911326688406039 0.181061634214724 no 844 0.196213477842593 665 NA Allantoinase, converts allantoin to allantoate in the first step of allantoin degradation; expression sensitive to nitrogen catabolite repression allantoin assimilation pathway allantoinase activity cellular_component
YLR300W YLR300W EXG1 hom Verified 0.91111356198275 0.18111777069842 no 845 0.16212186445681 570 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM Major exo-1,3-beta-glucanase of the cell wall, involved in cell wall beta-glucan assembly; exists as three differentially glycosylated isoenzymes fungal-type cell wall organization|cellular glucan metabolic process glucan exo-1,3-beta-glucosidase activity extracellular region|fungal-type cell wall
YPL137C YPL137C GIP3 hom Verified 0.910599986753521 0.18125308875129 no 846 0.183386215570892 613 NA FT CHROMOSOME SEGREGATION ENDOPLASMIC RETICULUM|MITOCHONDRION Cytoplasmic protein that regulates protein phosphatase 1 Glc7p; overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation; may interact with ribosomes, based on co-purification experiments; GIP3 has a paralog, HER1, that arose from the whole genome duplication chromosome segregation|regulation of phosphoprotein phosphatase activity protein phosphatase type 1 regulator activity|protein phosphatase 1 binding mitochondrion|ribosome|endoplasmic reticulum|cytoplasm
YDL230W YDL230W PTP1 hom Verified 0.909497603584969 0.181543761100603 no 847 0.156791175956173 510 NA FT MITOCHONDRION Phosphotyrosine-specific protein phosphatase that dephosphorylates a broad range of substrates in vivo, including Fpr3p; localized to the cytoplasm and the mitochondria; proposed to be a negative regulator of filamentation pseudohyphal growth|invasive growth in response to glucose limitation|protein dephosphorylation protein tyrosine phosphatase activity mitochondrion|cytoplasm
YBR172C YBR172C SMY2 hom Verified 0.909134913817996 0.181639457556959 no 848 0.154842813920485 524 NA FT VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Protein of unknown function involved in COPII vesicle formation; interacts with the Sec23p/Sec24p subcomplex; overexpression suppresses the temperature sensitivity of a myo2 mutant; similar to S. pombe Mpd2; SMY2 has a paralog, SYH1, that arose from the whole genome duplication ER to Golgi vesicle-mediated transport molecular_function endoplasmic reticulum membrane|cytoplasmic mRNA processing body|cytoplasm|extrinsic to membrane
YDR279W YDR279W RNH202 hom Verified 0.909072513057701 0.181655925310624 no 849 0.160053471919701 553 NA FT NUCLEUS Ribonuclease H2 subunit, required for RNase H2 activity; related to human AGS2 that causes Aicardi-Goutieres syndrome RNA catabolic process|DNA replication, removal of RNA primer ribonuclease H activity ribonuclease H2 complex|nucleus
YHR205W YHR205W SCH9 hom Verified 0.907499221068816 0.182071430603135 no 850 0.162821803210971 556 NA FT PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|RIBOSOME BIOGENESIS|PROTEIN PHOSPHORYLATION|RESPONSE TO OXIDATIVE STRESS NUCLEUS|CHROMOSOME AGC family protein kinase; functional ortholog of mammalian S6 kinase; phosphorylated by Tor1p and required for TORC1-mediated regulation of ribosome biogenesis, translation initiation, and entry into G0 phase; involved in transactivation of osmostress-responsive genes; regulates G1 progression, cAPK activity and nitrogen activation of the FGM pathway; integrates nutrient signals and stress signals from sphingolipids to regulate lifespan protein phosphorylation|age-dependent response to oxidative stress involved in chronological cell aging|replicative cell aging|regulation of protein localization|positive regulation of transcription from RNA polymerase III promoter|positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase I promoter|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|regulation of cell size|regulation of response to osmotic stress protein serine/threonine kinase activity chromatin|fungal-type vacuole membrane|nucleus|cytoplasm
YDR402C YDR402C DIT2 hom Verified 0.907302278881868 0.182123484706363 no 851 0.1949930510644 657 NA FT CELL WALL ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS N-formyltyrosine oxidase, sporulation-specific microsomal enzyme involved in the production of N,N-bisformyl dityrosine required for spore wall maturation, homologous to cytochrome P-450s ascospore wall assembly oxidoreductase activity cellular_component
YCR065W YCR065W HCM1 hom Verified 0.906577995675229 0.182315001163293 no 852 0.183586394748203 668 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION|RESPONSE TO OXIDATIVE STRESS NUCLEUS|CHROMOSOME Forkhead transcription factor that drives S-phase specific expression of genes involved in chromosome segregation, spindle dynamics, and budding; suppressor of calmodulin mutants with specific SPB assembly defects; telomere maintenance role positive regulation of transcription involved in S-phase of mitotic cell cycle|cellular response to oxidative stress|mitochondrion organization|spindle pole body organization|positive regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding nuclear chromatin|nucleus|cytoplasm
YLR335W YLR335W NUP2 hom Verified 0.906032586815608 0.182459302328214 no 853 0.188773264698667 671 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RNA LOCALIZATION|GENE SILENCING ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION|CHROMOSOME NUCLEAR PORE Nucleoporin involved in nucleocytoplasmic transport, binds to either the nucleoplasmic or cytoplasmic faces of the nuclear pore complex depending on Ran-GTP levels; also has a role in chromatin organization rRNA export from nucleus|snRNA export from nucleus|nuclear pore organization|tRNA export from nucleus|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|mRNA-binding (hnRNP) protein import into nucleus|ribosomal protein import into nucleus|snRNP protein import into nucleus|chromatin silencing at telomere|chromatin silencing at silent mating-type cassette|protein targeting to membrane|poly(A)+ mRNA export from nucleus|protein export from nucleus|mRNA export from nucleus in response to heat stress|transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery|NLS-bearing substrate import into nucleus|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, non-stop decay nucleocytoplasmic transporter activity nuclear chromatin|mitochondrion|integral to membrane|nuclear pore
YGR271C-A YGR271C-A EFG1 hom Verified 0.905775753852833 0.182527278430516 no 854 0.223641905644981 788 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Essential protein required for maturation of 18S rRNA; null mutant is sensitive to hydroxyurea and is delayed in recovering from alpha-factor arrest; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus G1 phase of mitotic cell cycle|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) molecular_function nucleolus
YMR258C YMR258C ROY1 hom Verified 0.90321092069756 0.183206981491084 no 855 0.188977158142684 680 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|NUCLEOTIDE METABOLISM|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM|NUCLEUS GTPase inhibitor with similarity to F-box proteins; inhibits Ypt52p GTPase activity by preventing Ypt52p from binding GTP; involved in regulating intracellular trafficking; physically interacts with Skp1p endocytosis|protein targeting to vacuole|negative regulation of GTPase activity GTPase inhibitor activity nucleus|cytoplasm
YPL088W_p YPL088W YPL088W hom Uncharacterized 0.902968248888352 0.183271373273218 no 856 0.181785308296177 619 NA FT OXIDATION-REDUCTION PROCESS Putative aryl alcohol dehydrogenase; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance cellular aldehyde metabolic process aryl-alcohol dehydrogenase (NAD+) activity cellular_component
YFL030W YFL030W AGX1 hom Verified 0.902205782962713 0.183473781710242 no 857 0.171910959046604 579 NA FT KETONE METABOLISM|AMINO ACID METABOLISM MITOCHONDRION Alanine:glyoxylate aminotransferase (AGT), catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast; has similarity to mammalian and plant alanine:glyoxylate aminotransferases glycine biosynthetic process, by transamination of glyoxylate alanine-glyoxylate transaminase activity mitochondrion
YGL168W YGL168W HUR1 hom Verified 0.901978314658437 0.183534193684884 no 858 0.2564915890574 862 NA FF|FT ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS Protein of unknown function; reported null mutant phenotype of hydroxyurea sensitivity may be due to effects on overlapping PMR1 gene DNA replication molecular_function cellular_component
YER099C YER099C PRS2 hom Verified 0.899110599157881 0.184296876503252 no 859 0.174381414120405 622 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; PRS2 has a paralog, PRS4, that arose from the whole genome duplication fungal-type cell wall organization|5-phosphoribose 1-diphosphate biosynthetic process ribose phosphate diphosphokinase activity cytoplasm
YIL052C YIL052C RPL34B hom Verified 0.89827320342309 0.184519957440883 no 860 0.22217936026111 769 NA FF|FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L34B; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34B has a paralog, RPL34A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YNL285W_d YNL285W YNL285W hom Dubious 0.897911390348299 0.184616395824181 no 861 0.176557533809489 590 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YPL108W_p YPL108W YPL108W hom Uncharacterized 0.896382560031574 0.185024239243018 no 862 0.197252184760558 664 NA Cytoplasmic protein of unknown function; non-essential gene that is induced in a GDH1 deleted strain with altered redox metabolism; GFP-fusion protein is induced in response to the DNA-damaging agent MMS biological_process molecular_function cytoplasm
YAL049C YAL049C AIM2 hom Verified 0.896290169068021 0.185048904143609 no 863 0.174371801568656 627 NA Cytoplasmic protein involved in mitochondrial function or organization; null mutant displays reduced frequency of mitochondrial genome loss; potential Hsp82p interactor biological_process molecular_function cytoplasm
YGR102C YGR102C GTF1 hom Verified 0.894503460095295 0.185526289651215 no 864 0.186667698377199 665 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION MITOCHONDRION Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is salt sensitive and null mutant has growth defects; non-tagged protein is detected in purified mitochondria glutaminyl-tRNAGln biosynthesis via transamidation glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity mitochondrion|glutamyl-tRNA(Gln) amidotransferase complex
YOL063C YOL063C CRT10 hom Verified 0.894030678997902 0.185652738409626 no 865 0.172110028549381 583 NA FT TRANSCRIPTION FROM RNA POL II Protein involved in transcriptional regulation of RNR2 and RNR3; expression of the gene is induced by DNA damage and null mutations confer increased resistance to hydroxyurea; N-terminal region has a leucine repeat and a WD40 repeat regulation of transcription from RNA polymerase II promoter molecular_function cellular_component
YBL081W_p YBL081W YBL081W hom Uncharacterized 0.892376803241477 0.186095500125496 no 866 0.163013024117737 544 NA Non-essential protein of unknown function; null mutation results in a decrease in plasma membrane electron transport biological_process molecular_function cellular_component
YBL093C YBL093C ROX3 hom Verified 0.890567857730954 0.186580524596048 no 867 0.209004263315213 713 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS RNA POL II, HOLOENZYME Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme negative regulation of transcription from RNA polymerase II promoter|transcriptional open complex formation at RNA polymerase II promoter|RNA polymerase II transcriptional preinitiation complex assembly|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II transcription factor recruiting transcription factor activity core mediator complex|nucleus
YIL093C YIL093C RSM25 hom Verified 0.890292261347165 0.186654487675214 no 868 0.20307032690006 732 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the small subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial small ribosomal subunit
YDL185W YDL185W VMA1 hom Verified 0.88890445127944 0.187027216492999 no 869 0.264525342646387 922 NA FF|FT ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS ENDOMEMBRANE SYSTEM Subunit A of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase; protein precursor undergoes self-catalyzed splicing to yield the extein Tfp1p and the intein Vde (PI-SceI), which is a site-specific endonuclease intron homing|cellular protein metabolic process|vacuolar acidification endodeoxyribonuclease activity|proton-transporting ATPase activity, rotational mechanism vacuolar proton-transporting V-type ATPase, V1 domain|fungal-type vacuole membrane
YDL179W YDL179W PCL9 hom Verified 0.888783242179743 0.18705979187747 no 870 0.193918658891253 664 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CELL DIVISION|PROTEIN PHOSPHORYLATION SITE OF POLARIZED GROWTH Cyclin, forms a functional kinase complex with Pho85p cyclin-dependent kinase (Cdk), expressed in late M/early G1 phase, activated by Swi5p regulation of establishment or maintenance of cell polarity|regulation of transcription involved in G1/S phase of mitotic cell cycle cyclin-dependent protein kinase regulator activity cyclin-dependent protein kinase holoenzyme complex|incipient cellular bud site|cellular bud neck
YNR002C YNR002C ATO2 hom Verified 0.888622646770506 0.187102957880599 no 871 0.158784364380786 519 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION|PLASMA MEMBRANE Putative transmembrane protein involved in export of ammonia; ammonia is a starvation signal that promotes cell death in aging colonies; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family; homolog of Y. lipolytica Gpr1p; ATO2 has a paralog, ADY2, that arose from the whole genome duplication ammonium transport|nitrogen utilization ammonium transmembrane transporter activity mitochondrion|integral to membrane|plasma membrane
YDL072C YDL072C YET3 hom Verified 0.887983821296648 0.187274727033085 no 872 0.183445192026838 621 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Protein of unknown function; YET3 null mutant decreases the level of secreted invertase; homolog of human BAP31 protein; protein abundance increases in response to DNA replication stress biological_process molecular_function integral to membrane|endoplasmic reticulum
YGR210C_p YGR210C YGR210C hom Uncharacterized 0.886062864850738 0.187791826225859 no 873 0.171421579361629 584 NA Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm biological_process molecular_function cytoplasm
YPR046W YPR046W MCM16 hom Verified 0.885967706376848 0.187817464685953 no 874 0.232914204275477 824 NA FT CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME KINETOCHORE Component of the Ctf19 complex and the COMA subcomplex; involved in kinetochore-microtubule mediated chromosome segregation; binds to centromere DNA; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-H and fission yeast fta3 chromosome segregation|establishment of mitotic sister chromatid cohesion molecular_function condensed nuclear chromosome kinetochore
YER116C YER116C SLX8 hom Verified 0.885591990921459 0.187918714471174 no 875 0.159278206237066 566 NA FT RESPONSE TO DNA DAMAGE NUCLEUS UBIQUITIN LIGASE COMPLEX Subunit of Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex; stimulated by prior attachment of SUMO to the substrate; contains a C-terminal RING domain; forms nuclear foci upon DNA replication stress protein sumoylation|telomere maintenance|response to DNA damage stimulus|protein ubiquitination ubiquitin-protein ligase activity ubiquitin ligase complex|nucleus
YBR026C YBR026C ETR1 hom Verified 0.885514120600082 0.187939703592179 no 876 0.215508598986028 724 NA FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION 2-enoyl thioester reductase, member of the medium chain dehydrogenase/reductase family; localized to in mitochondria, where it has a probable role in fatty acid synthesis fatty acid biosynthetic process|aerobic respiration enoyl-[acyl-carrier-protein] reductase activity mitochondrion
YGR187C YGR187C HGH1 hom Verified 0.884392701408311 0.188242130760702 no 877 0.187699641248304 656 NA Nonessential protein of unknown function; predicted to be involved in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; similar to mammalian BRP16 (Brain protein 16); relative distribution to the nucleus increases upon DNA replication stress biological_process molecular_function cytoplasm
YNL068C YNL068C FKH2 hom Verified 0.883401494789666 0.18850969171998 no 878 0.172793266482126 644 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|MITOCHONDRION ORGANIZATION|GENE SILENCING NUCLEUS|CHROMOSOME Forkhead family transcription factor; plays a major role in the expression of G2/M phase genes; positively regulates transcriptional elongation; negative role in chromatin silencing at HML and HMR; substrate of the Cdc28p/Clb5p kinase; FKH2 has a paralog, FKH1, that arose from the whole genome duplication negative regulation of chromatin silencing at silent mating-type cassette|positive regulation of transcription elongation from RNA polymerase II promoter|positive regulation of transcription involved in G2/M-phase of mitotic cell cycle|negative regulation of transcription involved in G1 phase of mitotic cell cycle|Unknown|chromatin remodeling|negative regulation of transcription involved in G2/M-phase of mitotic cell cycle RNA polymerase II transcription factor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II transcription factor binding transcription factor activity nucleus
YMR092C YMR092C AIP1 hom Verified 0.883345491918359 0.188524815828558 no 879 0.177049577433755 593 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION NUCLEUS|SITE OF POLARIZED GROWTH|CYTOSKELETON Actin cortical patch component; interacts with the actin depolymerizing factor cofilin; required to restrict cofilin localization to cortical patches; contains WD repeats; protein increases in abundance and relocalizes from cytoplasm to plasma membrane upon DNA replication stress actin filament depolymerization|response to osmotic stress actin binding nucleus|mating projection tip|cytoplasm|actin cortical patch
YLL055W YLL055W YCT1 hom Verified 0.882754096880626 0.188684573355725 no 880 0.164257291579406 527 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|PLASMA MEMBRANE High-affinity cysteine-specific transporter with similarity to the Dal5p family of transporters; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YCT1 is not an essential gene cysteine transport ion transmembrane transporter activity|cysteine transmembrane transporter activity integral to membrane|endoplasmic reticulum
YPR164W YPR164W MMS1 hom Verified 0.88265240706711 0.188712051916354 no 881 0.191529794856604 684 NA FT RESPONSE TO DNA DAMAGE NUCLEUS UBIQUITIN LIGASE COMPLEX Subunit of an E3 ubiquitin ligase complex involved in replication repair; stabilizes protein components of the replication fork such as the fork-pausing complex and leading strand polymerase, preventing fork collapse and promoting efficient recovery during replication stress; regulates Ty1 transposition; involved with Rtt101p in nonfunctional rRNA decay replication fork processing|negative regulation of transposition, RNA-mediated|recombinational repair|nonfunctional rRNA decay molecular_function Cul8-RING ubiquitin ligase complex
YOR303W YOR303W CPA1 hom Verified 0.882058393963915 0.188872615065129 no 882 0.168986562626954 533 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Small subunit of carbamoyl phosphate synthetase, which catalyzes a step in the synthesis of citrulline, an arginine precursor; translationally regulated by an attenuator peptide encoded by YOR302W within the CPA1 mRNA 5'-leader arginine biosynthetic process carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity carbamoyl-phosphate synthase complex
YPR154W YPR154W PIN3 hom Verified 0.881629383639747 0.188988629906674 no 883 0.196221615235813 640 NA FT CYTOSKELETON ORGANIZATION NUCLEUS Protein that induces appearance of [PIN+] prion when overproduced actin cytoskeleton organization molecular_function nucleus|cytoplasm
YGL006W YGL006W PMC1 hom Verified 0.881132387407752 0.189123084665437 no 884 0.175542262056332 595 NA FT ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS Vacuolar Ca2+ ATPase involved in depleting cytosol of Ca2+ ions; prevents growth inhibition by activation of calcineurin in the presence of elevated concentrations of calcium; similar to mammalian PMCA1a cellular calcium ion homeostasis|calcium ion transport|transmembrane transport calcium-transporting ATPase activity fungal-type vacuole membrane|integral to membrane
YKR050W YKR050W TRK2 hom Verified 0.880971853685483 0.189166527202384 no 885 0.203799103231658 659 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE Component of the Trk1p-Trk2p potassium transport system; TRK2 has a paralog, TRK1, that arose from the whole genome duplication cellular potassium ion homeostasis potassium ion transmembrane transporter activity integral to membrane|plasma membrane
YER169W YER169W RPH1 hom Verified 0.8797274248182 0.189503494427617 no 886 0.203755068872227 713 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION NUCLEUS JmjC domain-containing histone demethylase; specifically demethylates H3K36 tri- and dimethyl modification states; associates with actively transcribed (RNA polymerase II) regions in vivo and specifically targets H3K36 in its trimethylation state as its substrate; transcriptional repressor of PHR1; Rph1p phosphorylation during DNA damage is under control of the MEC1-RAD53 pathway; RPH1 has a paralog, GIS1, that arose from the whole genome duplication negative regulation of transcription from RNA polymerase II promoter|histone demethylation RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|sequence-specific DNA binding|histone demethylase activity (H3-K36 specific)|histone demethylase activity (H3-K9 specific) nucleus
YCR009C YCR009C RVS161 hom Verified 0.879475373830759 0.189571789905414 no 887 0.203680271103211 741 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION|RESPONSE TO NUTRIENT LEVELS SITE OF POLARIZED GROWTH|CYTOSKELETON Amphiphysin-like lipid raft protein; interacts with Rvs167p and regulates polarization of the actin cytoskeleton, endocytosis, cell polarity, cell fusion and viability following starvation or osmotic stress conjugation with cellular fusion|actin cytoskeleton reorganization|endocytosis|actin cortical patch localization|response to starvation|response to osmotic stress|lipid tube assembly|actin cytoskeleton organization cytoskeletal protein binding|lipid binding membrane raft|mating projection tip|mating projection|actin cortical patch
YGL214W_d YGL214W YGL214W hom Dubious 0.878696944803446 0.189782807822397 no 888 0.180412061764153 619 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; deletion mutation phenotype is likely due to the overlapping verified ORF SKI8/YGL213C Unknown Unknown Unknown
YDR156W YDR156W RPA14 hom Verified 0.878150333529754 0.18993107046563 no 889 0.156681991656094 558 NA FT NUCLEUS RNA polymerase I subunit A14 transcription of nuclear large rRNA transcript from RNA polymerase I promoter|regulation of cell size molecular_function DNA-directed RNA polymerase I complex
YIL159W YIL159W BNR1 hom Verified 0.878122387258572 0.189938652514885 no 890 0.184841767788217 637 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNI1 barbed-end actin filament capping|actin filament bundle assembly|formin-nucleated actin cable assembly profilin binding cellular bud neck
YLR174W YLR174W IDP2 hom Verified 0.87785582161816 0.190010983279437 no 891 0.163227039004678 548 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM Cytosolic NADP-specific isocitrate dehydrogenase; catalyzes oxidation of isocitrate to alpha-ketoglutarate; levels are elevated during growth on non-fermentable carbon sources and reduced during growth on glucose; IDP2 has a paralog, IDP3, that arose from the whole genome duplication glutamate biosynthetic process|isocitrate metabolic process isocitrate dehydrogenase (NADP+) activity cytosol
YKL105C YKL105C SEG2 hom Verified 0.877094802237934 0.19021757383129 no 892 0.171384741343591 574 NA Eisosome component and paralog of Seg1p; likely plays only minor role in eisosome assembly; shown to interact with Seg1p; similar to A. gossypii SEG gene which is important for stabilizing eisosomes biological_process molecular_function cellular_component
YCL002C_p YCL002C YCL002C hom Uncharacterized 0.876029529751207 0.19050699030664 no 893 0.190955709123151 666 NA Putative protein of unknown function; YCL002C is not an essential gene biological_process molecular_function integral to membrane
YLR266C YLR266C PDR8 hom Verified 0.874975756544673 0.190793548475666 no 894 0.176023066226569 593 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Transcription factor; targets include ATP-binding cassette (ABC) transporters, major facilitator superfamily transporters, and other genes involved in the pleiotropic drug resistance (PDR) phenomenon; PDR8 has a paralog, YRR1, that arose from the whole genome duplication positive regulation of transcription from RNA polymerase II promoter in response to stress RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|sequence-specific DNA binding nucleus
YBL022C YBL022C PIM1 hom Verified 0.874457669717706 0.190934531522495 no 895 0.237863187420881 800 NA FF|FT PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS|MITOCHONDRION ORGANIZATION|RESPONSE TO OXIDATIVE STRESS MITOCHONDRION ATP-dependent Lon protease, involved in degradation of misfolded proteins in mitochondria; required for biogenesis and maintenance of mitochondria chaperone-mediated protein complex assembly|misfolded or incompletely synthesized protein catabolic process ATP-dependent peptidase activity mitochondrion|mitochondrial matrix
YGR022C_d YGR022C YGR022C hom Dubious 0.872245366233653 0.191537267669377 no 896 0.155566136430776 531 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W Unknown Unknown Unknown
YNR071C_p YNR071C YNR071C hom Uncharacterized 0.871743948310435 0.191674039498232 no 897 0.183358771768147 615 NA FT CARBOHYDRATE METABOLISM Putative aldose 1-epimerase biological_process molecular_function cellular_component
YCR082W YCR082W AHC2 hom Verified 0.871640389610954 0.19170229466809 no 898 0.204057714775331 712 NA FT CHROMATIN ORGANIZATION NUCLEUS HISTONE ACETYLTRANSFERASE Component of the ADA histone acetyltransferase complex; Ach2p and Ach1p are unique to the ADA complex and not shared with the related SAGA and SLIK complexes; may tether Ach1p to the complex histone acetylation histone acetyltransferase activity Ada2/Gcn5/Ada3 transcription activator complex|nucleus|cytoplasm
YFL010C YFL010C WWM1 hom Verified 0.871188517713336 0.19182561417654 no 899 0.187089366229223 627 NA FT NUCLEUS|MITOCHONDRION WW domain containing protein of unknown function; binds to Mca1p, a caspase-related protease that regulates H2O2-induced apoptosis; overexpression causes G1 phase growth arrest and clonal death that is suppressed by overexpression of MCA1 biological_process molecular_function mitochondrion|nucleus|cytoplasm
YGL200C YGL200C EMP24 hom Verified 0.870248111282295 0.192082414394751 no 900 0.198297955943789 694 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS Component of the p24 complex; binds to GPI anchor proteins and mediates their efficient transport from the ER to the Golgi; integral membrane protein that associates with endoplasmic reticulum-derived COPII-coated vesicles protein retention in ER lumen|vesicle organization|ER to Golgi vesicle-mediated transport molecular_function integral to membrane|endoplasmic reticulum|ER to Golgi transport vesicle
YIL009W YIL009W FAA3 hom Verified 0.869871132248788 0.192185416472928 no 901 0.19186722012743 666 NA FT KETONE METABOLISM|LIPID METABOLISM Long chain fatty acyl-CoA synthetase, activates imported fatty acids; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery long-chain fatty acid metabolic process long-chain fatty acid-CoA ligase activity|very long-chain fatty acid-CoA ligase activity cellular_component
YLR114C YLR114C AVL9 hom Verified 0.869786463016331 0.192208555315005 no 902 0.205174007467718 680 NA FT VESICLE-MEDIATED TRANSPORT Conserved protein involved in exocytic transport from the Golgi; mutation is synthetically lethal with apl2 vps1 double mutation; member of a protein superfamily with orthologs in diverse organisms; relocalizes from bud neck to cytoplasm upon DNA replication stress post-Golgi vesicle-mediated transport molecular_function cytoplasm
YPL064C YPL064C CWC27 hom Verified 0.86943703808388 0.192304065980351 no 903 0.209147527130703 701 NA FT RNA PROCESSING NUCLEUS Component of a complex containing Cef1p; putatively involved in pre-mRNA splicing; has similarity to S. pombe Cwf27p; protein abundance increases in response to DNA replication stress biological_process molecular_function U2-type spliceosomal complex
YHR038W YHR038W RRF1 hom Verified 0.869397298360915 0.192314930143917 no 904 0.208831805000659 710 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial ribosome recycling factor, essential for mitochondrial protein synthesis and for the maintenance of the respiratory function of mitochondria mitochondrial translation translation release factor activity mitochondrion
YGL109W_d YGL109W YGL109W hom Dubious 0.866392857863434 0.193137379641626 no 905 0.156764162074226 529 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the uncharacterized gene YGL108C Unknown Unknown Unknown
YFL054C_p YFL054C YFL054C hom Uncharacterized 0.865977887400143 0.193251144111796 no 906 0.183250318657902 612 NA Putative channel-like protein; similar to Fps1p; mediates passive diffusion of glycerol in the presence of ethanol water transport|transmembrane transport water channel activity|glycerol transmembrane transporter activity|transporter activity integral to membrane
YJR140C YJR140C HIR3 hom Verified 0.865200359735898 0.193464413994688 no 907 0.197433061506175 679 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION NUCLEUS Subunit of the HIR complex; a nucleosome assembly complex involved in regulation of histone gene transcription; involved in position-dependent gene silencing and nucleosome reassembly; ortholog of human CABIN1 protein DNA replication-independent nucleosome assembly|regulation of transcription involved in G1/S phase of mitotic cell cycle|transcription elongation from RNA polymerase II promoter nucleosome binding|DNA binding|transcription corepressor activity HIR complex|nucleus
YDL047W YDL047W SIT4 hom Verified 0.862512379578087 0.1942028118632 no 908 0.197059491207927 697 NA FT CELL CYCLE|RNA PROCESSING|SIGNALING|RESPONSE TO DNA DAMAGE|CELL WALL ORG/BIOGENESIS|CELL DIVISION|CYTOSKELETON ORGANIZATION|RESPONSE TO OXIDATIVE STRESS NUCLEUS Type 2A-related serine-threonine phosphatase that functions in the G1/S transition of the mitotic cycle; cytoplasmic and nuclear protein that modulates functions mediated by Pkc1p including cell wall and actin cytoskeleton organization intracellular protein kinase cascade|replicative cell aging|G1/S transition of mitotic cell cycle|actin cytoskeleton organization|DNA repair|cellular response to oxidative stress|fungal-type cell wall organization|TOR signaling cascade|dephosphorylation|tRNA wobble uridine modification protein serine/threonine phosphatase activity nucleus|cytoplasm
YOR027W YOR027W STI1 hom Verified 0.862491783271055 0.194208476361538 no 909 0.201892782171691 692 NA Hsp90 cochaperone, interacts with the Ssa group of the cytosolic Hsp70 chaperones and activates Ssa1p ATPase activity; interacts with Hsp90 chaperones and inhibits their ATPase activity; homolog of mammalian Hop protein folding Hsp70 protein binding|Hsp90 protein binding|mRNA binding|ATPase inhibitor activity cytoplasm
YGR035C_p YGR035C YGR035C hom Uncharacterized 0.862121619861955 0.194310297690036 no 910 0.173668414991739 590 NA Putative protein of unknown function, potential Cdc28p substrate; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance biological_process molecular_function cellular_component
YIR034C YIR034C LYS1 hom Verified 0.86096828364982 0.194627755737622 no 911 0.213963572322646 700 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS Saccharopine dehydrogenase (NAD+, L-lysine-forming), catalyzes the conversion of saccharopine to L-lysine, which is the final step in the lysine biosynthesis pathway; also has mRNA binding activity lysine biosynthetic process|lysine biosynthetic process via aminoadipic acid saccharopine dehydrogenase (NAD+, L-lysine-forming) activity|mRNA binding cytoplasm
YNL183C YNL183C NPR1 hom Verified 0.859274955933003 0.195094418924562 no 912 0.179890179726089 641 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|PROTEIN PHOSPHORYLATION GOLGI APPARATUS|PLASMA MEMBRANE Protein kinase that stabilizes several plasma membrane amino acid transporters by antagonizing their ubiquitin-mediated degradation; phosphorylates Aly2p; negatively regulates Ldb19p-mediated endocytosis through phosphorylation of Ldb19p, which prevents its association with the plasma membrane; Npr1p activity is negatively regulated via phosphorylation by the TOR complex regulation of transmembrane transporter activity|regulation of nitrogen utilization|protein phosphorylation|negative regulation of endocytosis protein serine/threonine kinase activity Golgi apparatus|plasma membrane|cytoplasm
YIL025C_d YIL025C YIL025C hom Dubious 0.858989934249363 0.195173034704915 no 913 0.234171256939017 796 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YDR393W YDR393W SHE9 hom Verified 0.858364764582441 0.19534553882958 no 914 0.218227178520711 755 NA FT MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial inner membrane protein required for normal mitochondrial morphology, may be involved in fission of the inner membrane; forms a homo-oligomeric complex mitochondrion organization|inner mitochondrial membrane organization molecular_function mitochondrial inner membrane
YJL204C YJL204C RCY1 hom Verified 0.858081680521679 0.195423681151502 no 915 0.250639806968873 910 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION GOLGI APPARATUS|SITE OF POLARIZED GROWTH F-box protein involved in recycling plasma membrane proteins internalized by endocytosis; localized to sites of polarized growth early endosome to Golgi transport|endocytosis SNARE binding endosome|Golgi apparatus|site of polarized growth
YHR044C YHR044C DOG1 hom Verified 0.857599513227569 0.195556821970354 no 916 0.173598488726292 594 NA FT CARBOHYDRATE METABOLISM 2-deoxyglucose-6-phosphate phosphatase; paralogous to DOG2; member of a family of low molecular weight phosphatases; confers 2-deoxyglucose resistance when overexpressed, in vivo substrate has not yet been identified glucose metabolic process 2-deoxyglucose-6-phosphatase activity cellular_component
YLR121C YLR121C YPS3 hom Verified 0.85679107567247 0.195780179333409 no 917 0.199460581451345 698 NA FT CELL WALL ORG/BIOGENESIS|PROTEOLYSIS PLASMA MEMBRANE Aspartic protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor fungal-type cell wall organization|cellular protein metabolic process aspartic-type endopeptidase activity anchored to plasma membrane|plasma membrane
YGR189C YGR189C CRH1 hom Verified 0.856399306964763 0.195888473949352 no 918 0.176299004828437 586 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM Chitin transglycosylase that functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar and functionally redundant to Utr2; localizes to sites of polarized growth; expression induced by cell wall stress fungal-type cell wall organization|cell wall chitin metabolic process transferase activity, transferring glycosyl groups incipient cellular bud site|fungal-type cell wall
YLR343W YLR343W GAS2 hom Verified 0.856079377153732 0.195976937462963 no 919 0.152494439444995 512 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM PLASMA MEMBRANE 1,3-beta-glucanosyltransferase, involved with Gas4p in spore wall assembly; has similarity to Gas1p ascospore wall assembly 1,3-beta-glucanosyltransferase activity integral to membrane|cytoplasm
YDR206W YDR206W EBS1 hom Verified 0.85484281039852 0.196319087272578 no 920 0.203342734810716 605 NA FT TRANSLATION NUCLEUS|CHROMOSOME Protein involved in inhibition of translation and nonsense-mediated decay; interacts with cap binding protein Cdc33p and with Nam7p; localizes to P-bodies upon glucose starvation; mRNA abundance regulated by mRNA decay factors negative regulation of translation|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay molecular_function cytoplasmic mRNA processing body|cytoplasm
YDR022C YDR022C ATG31 hom Verified 0.853558685576949 0.196674779092611 no 921 0.185738405603173 639 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|CHROMOSOME SEGREGATION CYTOSKELETON Autophagy-specific protein required for autophagosome formation; may form a complex with Atg17p and Atg29p that localizes other proteins to the pre-autophagosomal structure; high-copy suppressor of CIK1 deletion autophagy|mitochondrion degradation|piecemeal microautophagy of nucleus molecular_function pre-autophagosomal structure|cytoplasm
YBR052C YBR052C RFS1 hom Verified 0.851800852615885 0.197162316536085 no 922 0.15137801718015 550 NA FT OXIDATION-REDUCTION PROCESS Protein of unknown function; member of a flavodoxin-like fold protein family that includes Pst2p and Ycp4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; RFS1 has a paralog, PST2, that arose from the whole genome duplication biological_process molecular_function membrane raft|cytoplasm
YJR117W YJR117W STE24 hom Verified 0.851473156622863 0.197253284281691 no 923 0.177411151793539 588 NA FT PROTEOLYSIS ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|MITOCHONDRION Highly conserved zinc metalloprotease that functions in two steps of a-factor maturation, C-terminal CAAX proteolysis and the first step of N-terminal proteolytic processing; contains multiple transmembrane spans CAAX-box protein processing|peptide pheromone maturation metalloendopeptidase activity mitochondrial outer membrane|integral to endoplasmic reticulum membrane|integral to membrane|nuclear inner membrane
YMR135C YMR135C GID8 hom Verified 0.85146143286346 0.197256539243982 no 924 0.202079925145934 682 NA FT KETONE METABOLISM|CELL CYCLE|CARBOHYDRATE METABOLISM|PROTEOLYSIS NUCLEUS Subunit of GID Complex, binds strongly to central component Vid30p; GID Complex is involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; recruits Rmd5p, Fyv10 and Vid28p to GID Complex; contains LisH, CTLH, and CRA domains that mediate binding to Vid30p (LisH) and Rmd5p and Vid28p (CTLH and CRA); dosage-dependent regulator of START negative regulation of gluconeogenesis|proteasomal ubiquitin-dependent protein catabolic process|traversing start control point of mitotic cell cycle molecular_function nucleus|GID complex|cytoplasm
YBR273C YBR273C UBX7 hom Verified 0.848719041417852 0.198018824077671 no 925 0.174828007905564 618 NA FT PROTEOLYSIS ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM UBX (ubiquitin regulatory X) domain-containing protein; interacts with Cdc48p; UBX7 has a paralog, UBX6, that arose from the whole genome duplication sporulation resulting in formation of a cellular spore|ubiquitin-dependent protein catabolic process molecular_function nuclear envelope|endoplasmic reticulum
YGL190C YGL190C CDC55 hom Verified 0.848705536663084 0.198022582303607 no 926 0.278585084173892 950 NA FT CELL CYCLE|SIGNALING NUCLEUS|SITE OF POLARIZED GROWTH Non-essential regulatory subunit B of protein phosphatase 2A (PP2A); localization to the cytoplasm requires Zds1p and Zds2p and promotes mitotic entry; localization to the nucleus prevents mitotic exit; required for correct nuclear division and chromosome segregation in meiosis; maintains nucleolar sequestration of Cdc14p during early meiosis; limits formation of PP2A-Rts1p holocomplexes to ensure timely dissolution of sister chromosome cohesion negative regulation of exit from mitosis|positive regulation of G2/M transition of mitotic cell cycle|cell shape checkpoint|protein dephosphorylation protein phosphatase type 2A regulator activity nucleus|cellular bud neck|cytoplasm|cellular bud tip
YHR143W YHR143W DSE2 hom Verified 0.848701845986612 0.198023609386104 no 927 0.260650943239151 911 NA FF|FT CELL WALL ORG/BIOGENESIS|CELL DIVISION Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother; expression is repressed by cAMP cytokinesis, completion of separation|pseudohyphal growth glucosidase activity extracellular region|fungal-type cell wall
YER187W_p YER187W YER187W hom Uncharacterized 0.847960238070987 0.198230057552322 no 928 0.176802520529152 569 NA Putative protein of unknown function; induced in respiratory-deficient cells biological_process molecular_function cellular_component
YGL067W YGL067W NPY1 hom Verified 0.846162593345448 0.198731023188879 no 929 0.141409957385221 427 NA FT NUCLEOTIDE METABOLISM|COFACTOR METABOLISM NADH diphosphatase (pyrophosphatase), hydrolyzes the pyrophosphate linkage in NADH and related nucleotides; localizes to peroxisomes; nudix hydrolase family member NADH metabolic process NAD+ diphosphatase activity peroxisome|cytoplasm
YNR030W YNR030W ALG12 hom Verified 0.845863528149618 0.198814440346255 no 930 0.229437921378185 753 NA FT LIPID METABOLISM|CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Alpha-1,6-mannosyltransferase localized to the ER; responsible for the addition of the alpha-1,6 mannose to dolichol-linked Man7GlcNAc2, acts in the dolichol pathway for N-glycosylation dolichol-linked oligosaccharide biosynthetic process|protein glycosylation alpha-1,6-mannosyltransferase activity integral to membrane|endoplasmic reticulum
YDR419W YDR419W RAD30 hom Verified 0.845591002629356 0.198890473267765 no 931 0.164806723052326 520 NA FT RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME DNA polymerase eta, involved in translesion synthesis during post-replication repair; catalyzes the synthesis of DNA opposite cyclobutane pyrimidine dimers and other lesions; may also have a role in protection against mitochondrial mutagenesis; mutations in human pol eta are responsible for XPV error-prone translesion synthesis|error-free translesion synthesis DNA-directed DNA polymerase activity replication fork
YNL134C YNL134C YNL134C hom Verified 0.845071931432464 0.19903533936866 no 932 0.174087422647945 540 NA FT OXIDATION-REDUCTION PROCESS NUCLEUS Protein of unknown function; similar to dehydrogenases from other model organisms; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress biological_process alcohol dehydrogenase (NADP+) activity nucleus|cytoplasm
YGR061C YGR061C ADE6 hom Verified 0.845054559011898 0.19904018888728 no 933 0.199535559851244 660 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEOTIDE METABOLISM Formylglycinamidine-ribonucleotide (FGAM)-synthetase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway 'de novo' IMP biosynthetic process|purine nucleotide biosynthetic process phosphoribosylformylglycinamidine synthase activity cytoplasm
YPL260W YPL260W YPL260W hom Verified 0.84389843668121 0.199363080931566 no 934 0.223890391156589 765 NA FT NUCLEUS Putative substrate of cAMP-dependent protein kinase (PKA); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YPL260W is not an essential gene; protein abundance increases in response to DNA replication stress biological_process molecular_function nucleus|cytoplasm
YLR327C YLR327C TMA10 hom Verified 0.843661698474115 0.199429238148497 no 935 0.200012030353423 707 NA FT NUCLEUS|MITOCHONDRION Protein of unknown function that associates with ribosomes; putative homolog of the F1F0-ATPase synthase regulator Stf2p; protein abundance increases in response to DNA replication stress biological_process molecular_function ribosome|nucleus|cytoplasm
YGL125W YGL125W MET13 hom Verified 0.841772396319122 0.199957682879325 no 936 0.210967466939491 663 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS MITOCHONDRION Major isozyme of methylenetetrahydrofolate reductase, catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate in the methionine biosynthesis pathway methionine biosynthetic process methylenetetrahydrofolate reductase (NADPH) activity mitochondrion
YMR106C YMR106C YKU80 hom Verified 0.840814968269147 0.200225800160284 no 937 0.184630727572214 662 NA FT PROTEIN LOCALIZATION|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING NUCLEUS|CHROMOSOME Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair chromatin assembly or disassembly|protein localization to chromosome|chromatin silencing|double-strand break repair via nonhomologous end joining|donor selection|telomere maintenance|double-strand break repair via homologous recombination damaged DNA binding|RNA binding|DNA binding|telomeric DNA binding nuclear chromatin|nuclear telomeric heterochromatin|Ku70:Ku80 complex
YPL036W YPL036W PMA2 hom Verified 0.839999503649385 0.200454332409302 no 938 0.171082130561062 550 NA FT ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS MITOCHONDRION|PLASMA MEMBRANE Plasma membrane H+-ATPase, isoform of Pma1p, involved in pumping protons out of the cell; regulator of cytoplasmic pH and plasma membrane potential proton transport|regulation of pH hydrogen-exporting ATPase activity, phosphorylative mechanism mitochondrion|integral to membrane|plasma membrane
YML089C_d YML089C YML089C hom Dubious 0.839993524439827 0.200456008648603 no 939 0.187814095763792 595 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; expression induced by calcium shortage Unknown Unknown Unknown
YNL228W_d YNL228W YNL228W hom Dubious 0.839690931696923 0.200540849893261 no 940 0.223212296031546 762 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps ORF YNL227C/JJJ1 Unknown Unknown Unknown
YMR303C YMR303C ADH2 hom Verified 0.839325164735439 0.200643432767084 no 941 0.197742704878928 679 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM Glucose-repressible alcohol dehydrogenase II, catalyzes the conversion of ethanol to acetaldehyde; involved in the production of certain carboxylate esters; regulated by ADR1 ethanol metabolic process|NADH oxidation|fermentation|amino acid catabolic process to alcohol via Ehrlich pathway alcohol dehydrogenase (NAD) activity cytoplasm
YKR015C_p YKR015C YKR015C hom Uncharacterized 0.839055603968253 0.200719053845658 no 942 0.174498511843695 576 NA Putative protein of unknown function biological_process molecular_function cellular_component
YKL067W YKL067W YNK1 hom Verified 0.838456305231313 0.200887239068093 no 943 0.167766320740685 564 NA FT RESPONSE TO DNA DAMAGE|NUCLEOTIDE METABOLISM MITOCHONDRION Nucleoside diphosphate kinase; catalyzes the transfer of gamma phosphates from nucleoside triphosphates, usually ATP, to nucleoside diphosphates by a mechanism that involves formation of an autophosphorylated enzyme intermediate; protein abundance increases in response to DNA replication stress nucleoside diphosphate phosphorylation|nucleoside triphosphate biosynthetic process|response to DNA damage stimulus nucleoside diphosphate kinase activity cytosol|mitochondrion|mitochondrial intermembrane space
YPL097W YPL097W MSY1 hom Verified 0.83839024379419 0.200905783505014 no 944 0.212915930126846 721 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial tyrosyl-tRNA synthetase mitochondrial tyrosyl-tRNA aminoacylation tyrosine-tRNA ligase activity mitochondrion
YKL093W YKL093W MBR1 hom Verified 0.837304274572742 0.201210778570023 no 945 0.191540467511596 702 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Protein involved in mitochondrial functions and stress response; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants aerobic respiration molecular_function cellular_component
YPL066W YPL066W RGL1 hom Verified 0.835296240534982 0.201775466807989 no 946 0.239231650018954 852 NA FF|FT SITE OF POLARIZED GROWTH Regulator of Rho1p signaling, cofactor of Tus1p; required for the localization of Tus1p during all phases of cytokinesis; green fluorescent protein (GFP)-fusion protein localizes to the bud neck and cytoplasm; null mutant is viable and exhibits growth defect on a non-fermentable (respiratory) carbon source protein localization to bud neck molecular_function cellular bud neck|cytoplasm
YKR017C YKR017C HEL1 hom Verified 0.835077639142255 0.20183699791185 no 947 0.207457060220461 711 NA RING finger ubiquitin ligase (E3); involved in ubiquitylation and degradation of excess histones; interacts with Ubc4p and Rad53p; null mutant sensitive to hydroxyurea (HU) biological_process molecular_function cellular_component
YHR091C YHR091C MSR1 hom Verified 0.833628261353966 0.202245247469858 no 948 0.196763469987144 679 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial arginyl-tRNA synthetase; mutations in human ortholog are associated with pontocerebellar hypoplasia type 6 arginyl-tRNA aminoacylation|mitochondrial arginyl-tRNA aminoacylation|mitochondrial translation arginine-tRNA ligase activity mitochondrion
YDR326C YDR326C YSP2 hom Verified 0.832540405691434 0.202551990528257 no 949 0.209253768679932 751 NA FT MITOCHONDRION Protein involved in programmed cell death; mutant shows resistance to cell death induced by amiodarone or intracellular acidification; YSP2 has a paralog, YHR080C, that arose from the whole genome duplication apoptotic process molecular_function mitochondrion
YOL050C_d YOL050C YOL050C hom Dubious 0.832118759093033 0.202670957120506 no 950 0.221017584197496 747 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps verified gene GAL11; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) Unknown Unknown Unknown
YKL121W_p YKL121W DGR2 hom Uncharacterized 0.829210980465834 0.203492516326068 no 951 0.205691362570392 690 NA Protein of unknown function; null mutant is resistant to 2-deoxy-D-glucose and displays abnormally elongated buds biological_process molecular_function cellular_component
YGR285C YGR285C ZUO1 hom Verified 0.829149512135562 0.203509904905105 no 952 0.202784806904812 698 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION NUCLEUS|MITOCHONDRION RIBOSOME Ribosome-associated chaperone, functions in ribosome biogenesis and, in partnership with Ssz1p and SSb1/2, as a chaperone for nascent polypeptide chains; contains a DnaJ domain and functions as a J-protein partner for Ssb1p and Ssb2p protein folding|ribosomal subunit export from nucleus|rRNA processing|regulation of translational fidelity unfolded protein binding mitochondrion|ribosome|nucleolus|polysome|cytoplasm
YOR090C YOR090C PTC5 hom Verified 0.827172222922937 0.204069726585677 no 953 0.209400191255511 658 NA FT MITOCHONDRION Mitochondrial type 2C protein phosphatase (PP2C) involved in regulation of pyruvate dehydrogenase activity by dephosphorylating the serine 133 of the Pda1p subunit; localizes to the intermembrane space and is imported via the presequence pathway and processed by the inner membrane protease (Imp1p-Imp2p); acts in concert with kinases Pkp1p and Pkp2p and phosphatase Ptc6p positive regulation of catalytic activity|regulation of catalytic activity|protein dephosphorylation [pyruvate dehydrogenase (lipoamide)] phosphatase activity|protein serine/threonine phosphatase activity mitochondrion
YLR108C YLR108C YLR108C hom Verified 0.827171819091303 0.204069841014469 no 954 0.219546857204016 731 NA FT NUCLEUS Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YLR108C is not an esssential gene; protein abundance increases in response to DNA replication stress; YLR108C has a paralog, YDR132C, that arose from the whole genome duplication biological_process molecular_function nucleus
YIL094C YIL094C LYS12 hom Verified 0.826973788037909 0.2041259592385 no 955 0.204618159298688 704 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS MITOCHONDRION Homo-isocitrate dehydrogenase, an NAD-linked mitochondrial enzyme required for the fourth step in the biosynthesis of lysine, in which homo-isocitrate is oxidatively decarboxylated to alpha-ketoadipate lysine biosynthetic process homoisocitrate dehydrogenase activity mitochondrion
YHR116W YHR116W COX23 hom Verified 0.826571729897225 0.204239923120531 no 956 0.200937184905792 684 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial intermembrane space protein that functions in mitochondrial copper homeostasis, essential for functional cytochrome oxidase expression; homologous to Cox17p; contains twin cysteine-x9-cysteine motifs mitochondrial respiratory chain complex assembly molecular_function mitochondrion|cytoplasm
YPR036W YPR036W VMA13 hom Verified 0.826017912029494 0.2043969655109 no 957 0.260106715346936 912 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS Subunit H of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; serves as an activator or a structural stabilizer of the V-ATPase vacuolar acidification proton-transporting ATPase activity, rotational mechanism vacuolar proton-transporting V-type ATPase, V1 domain|fungal-type vacuole membrane|integral to membrane
YFR011C YFR011C AIM13 hom Verified 0.825555781971562 0.204528063606948 no 958 0.186097957262897 647 NA FT MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial protein peripheral to the inner membrane; component of the mitochondrial inner membrane organizing system (MINOS, MitOS, or MICOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture cristae formation molecular_function mitochondrion|extrinsic to mitochondrial inner membrane|mitochondrial crista junction|cytoplasm|mitochondrial intermembrane space
YDL040C YDL040C NAT1 hom Verified 0.825527688816133 0.204536034749634 no 959 0.196379476499761 675 NA FT MITOCHONDRION RIBOSOME Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing N-terminal protein amino acid acetylation peptide alpha-N-acetyltransferase activity mitochondrion|NatA complex|cytosolic ribosome
YKR106W YKR106W GEX2 hom Verified 0.824253995807487 0.204897626145964 no 960 0.189525205246065 615 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE Proton:glutathione antiporter localized to the vacuolar and plasma membranes; expressed at a very low level; almost identical to paralog Gex1p; potential role in resistance to oxidative stress and modulation of the PKA pathway glutathione transmembrane transport solute:hydrogen antiporter activity integral to membrane|plasma membrane|vacuolar membrane
YLR214W YLR214W FRE1 hom Verified 0.823353584612365 0.205153474948783 no 961 0.180010673662584 610 NA FT ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|GEN. OF PRECURSOR METABOLITES AND ENERGY PLASMA MEMBRANE Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low copper and iron levels iron ion transport|copper ion import ferric-chelate reductase activity integral to membrane|plasma membrane
YJR050W YJR050W ISY1 hom Verified 0.823247369946284 0.205183668000631 no 962 0.228050876914907 763 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING NUCLEUS Member of NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of spliceosome containing U2, U5, and U6 snRNAs, interacts with Prp16p to modulate splicing fidelity; isy1 syf2 cells have defective spindles generation of catalytic spliceosome for second transesterification step|mRNA 3'-splice site recognition first spliceosomal transesterification activity|second spliceosomal transesterification activity post-spliceosomal complex|Prp19 complex|post-mRNA release spliceosomal complex|U2-type catalytic step 2 spliceosome|U2-type catalytic step 1 spliceosome
YOL084W YOL084W PHM7 hom Verified 0.823155019865003 0.205209921989905 no 963 0.157131174169668 514 NA FT PLASMA MEMBRANE Protein of unknown function; expression is regulated by phosphate levels; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole; protein abundance increases in response to DNA replication stress biological_process molecular_function integral to membrane|fungal-type vacuole
YOL099C_d YOL099C YOL099C hom Dubious 0.822801131117761 0.205310546674287 no 964 0.173992110516678 624 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene PKH2/YOL100W; may interact with ribosomes Unknown Unknown Unknown
YNL296W_d YNL296W YNL296W hom Dubious 0.822603957184486 0.205366623799402 no 965 0.239817576502472 834 NA Dubious open reading frame unlikely to encode a functional protein; deletion adversely affects sporulation; deletion mutant exhibits synthetic phenotype under expression of mutant huntingtin fragment, but gene does not have human ortholog Unknown Unknown Unknown
YDR225W YDR225W HTA1 hom Verified 0.822484150673778 0.205400701735409 no 966 0.213415205802673 760 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME RSC COMPLEX Histone H2A, core histone protein required for chromatin assembly and chromosome function; one of two nearly identical subtypes (see also HTA2); DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p DNA repair|chromatin assembly or disassembly|negative regulation of transcription from RNA polymerase II promoter DNA binding replication fork protection complex|nuclear nucleosome
YPL120W YPL120W VPS30 hom Verified 0.822162540400833 0.205492197629974 no 967 0.212941535502248 756 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|MEMBRANE ORGANIZATION|PROTEOLYSIS|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS|PEROXISOME ORGANIZATION Subunit of phosphatidylinositol (PtdIns) 3-kinase complexes I and II; Complex I is essential in autophagy and Complex II is required for vacuolar protein sorting; required for overflow degradation of misfolded proteins when ERAD is saturated; ortholog of the higher eukaryotic gene Beclin 1 phosphatidylinositol biosynthetic process|piecemeal microautophagy of nucleus|ER-associated protein catabolic process|peroxisome degradation|retrograde transport, endosome to Golgi|macroautophagy|CVT pathway|late endosome to vacuole transport 1-phosphatidylinositol-3-kinase activity phosphatidylinositol 3-kinase complex I|phosphatidylinositol 3-kinase complex II|extrinsic to membrane|cytoplasm
YNR019W YNR019W ARE2 hom Verified 0.821669057432542 0.205632637162049 no 968 0.207658384596579 695 NA FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Acyl-CoA:sterol acyltransferase; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the presence of oxygen; ARE2 has a paralog, ARE1, that arose from the whole genome duplication ergosterol metabolic process ergosterol O-acyltransferase activity integral to membrane|endoplasmic reticulum
YBR031W YBR031W RPL4A hom Verified 0.821465295562294 0.205690642043085 no 969 0.196462214048677 708 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L4A; N-terminally acetylated; homologous to mammalian ribosomal protein L4 and bacterial L4; RPL4A has a paralog, RPL4B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YDR372C YDR372C VPS74 hom Verified 0.821418830006182 0.205703870750137 no 970 0.24382190499282 822 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING ENDOMEMBRANE SYSTEM|NUCLEUS|GOLGI APPARATUS Golgi phosphatidylinositol-4-kinase effector and PtdIns4P sensor; interacts with the cytosolic domains of cis and medial glycosyltransferases, and in the PtdIns4P-bound state mediates the targeting of these enzymes to the Golgi; interacts with the catalytic domain of Sac1p, the major cellular PtdIns4P phosphatase, to direct dephosphosphorylation of the Golgi pool of PtdIns4P; tetramerization required for function; ortholog of human GOLPH3/GPP34/GMx33 retrograde vesicle-mediated transport, Golgi to ER|endoplasmic reticulum unfolded protein response|protein localization to Golgi apparatus enzyme binding|phosphatidylinositol-4-phosphate binding cytosol|Golgi apparatus|nucleus|extrinsic to membrane|cytoplasm
YHL029C_p YHL029C OCA5 hom Uncharacterized 0.821238543088031 0.205755203073163 no 971 0.233400508739171 818 NA FT SIGNALING|NUCLEOTIDE METABOLISM Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts biological_process molecular_function cytoplasm
YGL203C YGL203C KEX1 hom Verified 0.821088132979201 0.20579803451584 no 972 0.204197259585915 677 NA FT PROTEOLYSIS GOLGI APPARATUS Protease involved in the processing of killer toxin and alpha factor precursor; cleaves Lys and Arg residues from the C-terminus of peptides and proteins protein processing serine-type carboxypeptidase activity trans-Golgi network
YLR252W_d YLR252W YLR252W hom Dubious 0.821009476402441 0.205820435214386 no 973 0.220375197177964 727 NA Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene SYM1, a mitochondrial protein involved in ethanol metabolism Unknown Unknown Unknown
YLR225C_p YLR225C YLR225C hom Uncharacterized 0.82001146673464 0.206104785164894 no 974 0.213078242794206 743 NA FT RESPONSE TO OXIDATIVE STRESS Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR225C is not an essential gene biological_process molecular_function cytoplasm
YKL023W_p YKL023W YKL023W hom Uncharacterized 0.819850259949364 0.206150737564869 no 975 0.197290276224944 722 NA Putative protein of unknown function, predicted by computational methods to be involved in mRNA degradation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm biological_process molecular_function cytoplasm
YIL077C_p YIL077C YIL077C hom Uncharacterized 0.819335392828523 0.206297542408768 no 976 0.226179542195429 759 NA FT MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) biological_process molecular_function mitochondrion
YKL205W YKL205W LOS1 hom Verified 0.81893802022576 0.206410888215146 no 977 0.21377178691081 704 NA FT RNA PROCESSING|RNA LOCALIZATION NUCLEUS|MITOCHONDRION Nuclear pore protein involved in nuclear export of pre-tRNA and in re-export of mature tRNAs after their retrograde import from the cytoplasm tRNA re-export from nucleus|tRNA splicing, via endonucleolytic cleavage and ligation|tRNA export from nucleus tRNA binding|Ran GTPase binding mitochondrion|integral to membrane|nuclear matrix|cytoplasm
YNL274C YNL274C GOR1 hom Verified 0.818785500373863 0.206454402485534 no 978 0.182789575501327 591 NA FT KETONE METABOLISM|OXIDATION-REDUCTION PROCESS NUCLEUS|MITOCHONDRION Glyoxylate reductase; null mutation results in increased biomass after diauxic shift; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress glyoxylate catabolic process|metabolic process oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|glyoxylate reductase activity mitochondrion|nucleus|cytoplasm
YOR311C YOR311C DGK1 hom Verified 0.818164269359433 0.2066316972901 no 979 0.182662172953983 591 NA FT VESICLE-MEDIATED TRANSPORT|KETONE METABOLISM|LIPID METABOLISM ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|GOLGI APPARATUS Diacylglycerol kinase, localized to the endoplasmic reticulum (ER); overproduction induces enlargement of ER-like membrane structures and suppresses a temperature-sensitive sly1 mutation; contains a CTP transferase domain phosphatidic acid biosynthetic process diacylglycerol kinase activity integral to endoplasmic reticulum membrane|integral to membrane
YIL152W_p YIL152W YIL152W hom Uncharacterized 0.817937785541917 0.206696356543188 no 980 0.181142389680934 591 NA Putative protein of unknown function biological_process molecular_function cellular_component
YLR361C YLR361C DCR2 hom Verified 0.817480712973533 0.206826883455093 no 981 0.180790114741042 600 NA FT CELL CYCLE|SIGNALING Phosphoesterase involved in downregulation of the unfolded protein response, at least in part via dephosphorylation of Ire1p; dosage-dependent positive regulator of the G1/S phase transition through control of the timing of START endoplasmic reticulum unfolded protein response|traversing start control point of mitotic cell cycle|protein dephosphorylation hydrolase activity, acting on ester bonds|phosphoprotein phosphatase activity|phosphoric ester hydrolase activity cellular_component
YDR005C YDR005C MAF1 hom Verified 0.81739438897387 0.206851540608242 no 982 0.224137737159058 772 NA FT NUCLEUS Highly conserved negative regulator of RNA polymerase III; binds to the N-terminal domain of the Rpc160p subunit of Pol III to prevent closed-complex formation; localization and activity are regulated by phosphorylation, mediated by TORC1, protein kinase A, and Sch9p; localizes to cytoplasm during vegetative growth and translocates to the nucleus and nucleolus under stress conditions negative regulation of transcription from RNA polymerase III promoter RNA polymerase III core binding nucleolus|nucleus|cytoplasm
YFR014C YFR014C CMK1 hom Verified 0.816768059591744 0.207030494288005 no 983 0.179244136387021 545 NA FT SIGNALING|PROTEIN PHOSPHORYLATION Calmodulin-dependent protein kinase; may play a role in stress response, many Ca++/calmodulin dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to mammalian Cam Kinase II; CMK1 has a paralog, CMK2, that arose from the whole genome duplication signal transduction|protein phosphorylation protein kinase activity|calmodulin-dependent protein kinase activity cytoplasm
YOL019W_p YOL019W YOL019W hom Uncharacterized 0.816374798700629 0.207142902866075 no 984 0.218437465225789 724 NA FT PLASMA MEMBRANE Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole; YOL019W has a paralog, DCV1, that arose from the whole genome duplication biological_process molecular_function integral to membrane|plasma membrane|fungal-type vacuole
YDL215C YDL215C GDH2 hom Verified 0.815917770491941 0.207273583860947 no 985 0.191331470793772 583 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS MITOCHONDRION NAD(+)-dependent glutamate dehydrogenase, degrades glutamate to ammonia and alpha-ketoglutarate; expression sensitive to nitrogen catabolite repression and intracellular ammonia levels nitrogen compound metabolic process glutamate dehydrogenase (NAD+) activity mitochondrion
YGL253W YGL253W HXK2 hom Verified 0.813804695734556 0.207878422304182 no 986 0.210630465318099 726 NA FT CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS|GEN. OF PRECURSOR METABOLITES AND ENERGY NUCLEUS|MITOCHONDRION Hexokinase isoenzyme 2; catalyzes phosphorylation of glucose in the cytosol; predominant hexokinase during growth on glucose; functions in the nucleus to repress expression of HXK1 and GLK1 and to induce expression of its own gene; phosphorylation/dephosphorylation at serine-14 by protein kinase Snf1p and protein phosphatase Glc7p-Reg1p regulates nucleocytoplasmic shuttling of Hxk2p; HXK2 has a paralog, HXK1, that arose from the whole genome duplication replicative cell aging|fructose import|regulation of transcription by glucose|glucose import|mannose metabolic process|glycolysis|glucose metabolic process|regulation of cell size|fructose metabolic process hexokinase activity cytosol|mitochondrion|nucleus
YMR294W-A_d YMR294W-A YMR294W-A hom Dubious 0.813477921678163 0.207972049823372 no 987 0.226362161932456 743 NA Dubious open reading frame unlikely to encode a functional protein, substantially overlaps YMR295C; deletion causes sensitivity to unfolded protein response-inducing agents Unknown Unknown Unknown
YGR042W YGR042W YGR042W hom Verified 0.812543286362635 0.20823997955472 no 988 0.181604749858027 640 NA FT NUCLEUS Protein of unknown function; involved in maintenance of proper telomere length; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; forms nuclear foci upon DNA replication stress biological_process molecular_function nucleus|cytoplasm
YDR183W YDR183W PLP1 hom Verified 0.81217002734925 0.20834703772994 no 989 0.192695890192502 629 NA FT TRANSCRIPTION FROM RNA POL II|SIGNALING Protein that interacts with CCT (chaperonin containing TCP-1) complex and has a role in actin and tubulin folding; has weak similarity to phosducins, which are G-protein regulators protein folding|positive regulation of transcription from RNA polymerase II promoter by pheromones G-protein beta/gamma-subunit complex binding cellular_component
YPR051W YPR051W MAK3 hom Verified 0.811743235111307 0.208469490084424 no 990 0.246686468152367 861 NA FT NUCLEUS Catalytic subunit of N-terminal acetyltransferase of the NatC type; required for replication of dsRNA virus N-terminal protein amino acid acetylation peptide alpha-N-acetyltransferase activity NatC complex
YFR017C YFR017C IGD1 hom Verified 0.81091183427064 0.208708151842329 no 991 0.212338592491507 697 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY Cytoplasmic protein that inhibits Gdb1p glycogen debranching activity; required for normal intracellular accumulation of glycogen; phosphorylated in vivo; expression increases during wine fermentation; protein abundance increases in response to DNA replication stress; IGD1 has a paralog, YOL024W, that arose from the whole genome duplication negative regulation of glycogen catabolic process enzyme inhibitor activity cytoplasm
YBR233W YBR233W PBP2 hom Verified 0.809982351524753 0.208975159530717 no 992 0.217134895417773 710 NA FT NUCLEUS RNA binding protein; has similarity to mammalian heterogeneous nuclear RNP K protein, involved in the regulation of telomere position effect and telomere length; relative distribution to the nucleus increases upon DNA replication stress telomere maintenance via telomere shortening mRNA binding cytoplasm
YAL044W-A_p YAL044W-A YAL044W-A hom Uncharacterized 0.80949479559561 0.209115297606887 no 993 0.171294278654677 557 NA Putative protein of unknown function; similar to S. pombe uvi31 which is a putative DNA repair protein biological_process molecular_function cellular_component
YOL125W YOL125W TRM13 hom Verified 0.808656618549489 0.209356343913145 no 994 0.166372708737666 559 NA FT RNA PROCESSING NUCLEUS 2'-O-methyltransferase responsible for modification of tRNA at position 4; C-terminal domain has similarity to Rossmann-fold (RFM) superfamily of RNA methyltransferases tRNA methylation tRNA methyltransferase activity nucleus|cytoplasm
YGL259W_p YGL259W YPS5 hom Uncharacterized 0.808315807611361 0.209454402426608 no 995 0.196494554920111 667 NA FT PROTEOLYSIS Protein with similarity to GPI-anchored aspartic proteases such as Yap1p and Yap3p biological_process aspartic-type endopeptidase activity cellular_component
YPL027W YPL027W SMA1 hom Verified 0.806748532324724 0.209905688403135 no 996 0.180730784535475 593 NA FT MEMBRANE ORGANIZATION Protein of unknown function involved in the assembly of the prospore membrane during sporulation; interacts with Spo14p ascospore-type prospore membrane assembly molecular_function prospore membrane
YIL113W YIL113W SDP1 hom Verified 0.804565676166845 0.210535177903957 no 997 0.228329729909093 764 NA FT SIGNALING|CELL WALL ORG/BIOGENESIS|PROTEIN PHOSPHORYLATION NUCLEUS Stress-inducible dual-specificity MAP kinase phosphatase, negatively regulates Slt2p MAP kinase by direct dephosphorylation, diffuse localization under normal conditions shifts to punctate localization after heat shock inactivation of MAPK activity involved in cell wall biogenesis|MAPK cascade involved in cell wall biogenesis MAP kinase tyrosine phosphatase activity nucleus|cytoplasm
YBL017C YBL017C PEP1 hom Verified 0.804180556799373 0.210646353037875 no 998 0.176812380524881 570 NA FT PROTEIN LOCALIZATION|VACUOLAR TRANSPORT GOLGI APPARATUS Type I transmembrane sorting receptor for multiple vacuolar hydrolases; cycles between the late-Golgi and prevacuolar endosome-like compartments vacuolar transport|protein targeting to vacuole signal sequence binding integral to membrane|Golgi apparatus
YPL074W YPL074W YTA6 hom Verified 0.803801400103731 0.210755840526388 no 999 0.161107595042647 597 NA Putative ATPase of the CDC48/PAS1/SEC18 (AAA) family; localized to the cortex of mother cells but not to daughter cells; relocalizes from cytoplasm to plasma membrane foci upon DNA replication stress biological_process ATPase activity cell cortex
YHR060W YHR060W VMA22 hom Verified 0.802823086436445 0.211038498195138 no 1000 0.21534234013273 714 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|ION HOMEOSTASIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Peripheral membrane protein that is required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the yeast endoplasmic reticulum (ER) vacuolar proton-transporting V-type ATPase complex assembly|vacuolar acidification unfolded protein binding extrinsic to endoplasmic reticulum membrane
YDR278C_d YDR278C YDR278C hom Dubious 0.802601192216343 0.211102639520591 no 1001 0.196308310051243 672 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YML047W-A_d YML047W-A YML047W-A hom Dubious 0.80066029480788 0.21166416728118 no 1002 0.207172541910803 672 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YHR016C YHR016C YSC84 hom Verified 0.799675615957879 0.211949382092774 no 1003 0.217279548200197 719 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION CYTOSKELETON Actin-binding protein; involved in bundling of actin filaments and endocytosis of actin cortical patches; activity stimulated by Las17p; contains SH3 domain similar to Rvs167p; YSC84 has a paralog, LSB3, that arose from the whole genome duplication endocytosis|actin filament organization|actin filament bundle assembly|actin cortical patch localization|actin cytoskeleton organization actin filament binding actin cortical patch
YMR064W YMR064W AEP1 hom Verified 0.798210862631166 0.212374067388615 no 1004 0.243989433945356 839 NA FT TRANSLATION MITOCHONDRION Protein required for expression of the mitochondrial OLI1 gene encoding subunit 9 of F1-F0 ATP synthase regulation of translation translation regulator activity mitochondrion
YBR035C YBR035C PDX3 hom Verified 0.797469887216318 0.212589092382706 no 1005 0.204970184613072 735 NA FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM Pyridoxine (pyridoxamine) phosphate oxidase, has homologs in E. coli and Myxococcus xanthus; transcription is under the general control of nitrogen metabolism fatty acid metabolic process pyridoxamine-phosphate oxidase activity cellular_component
YCR051W_p YCR051W YCR051W hom Uncharacterized 0.797388355272089 0.212612760047507 no 1006 0.208817226047711 736 NA FT NUCLEUS Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; contains ankyrin (Ank) repeats; YCR051W is not an essential gene biological_process molecular_function nucleus|cytoplasm
YDR115W YDR115W YDR115W hom Verified 0.796117178202667 0.212981965227588 no 1007 0.213951040129735 691 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Putative mitochondrial ribosomal protein of the large subunit; similar to E. coli L34 ribosomal protein; required for respiratory growth, as are most mitochondrial ribosomal proteins; protein increases in abundance and relocalizes to the plasma membrane upon DNA replication stress mitochondrial translation structural constituent of ribosome mitochondrial large ribosomal subunit
YMR199W YMR199W CLN1 hom Verified 0.793614877957358 0.213709834204615 no 1008 0.192467210321503 677 NA FT CELL CYCLE|CELL DIVISION|PROTEIN PHOSPHORYLATION NUCLEUS G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p) regulation of cyclin-dependent protein kinase activity cyclin-dependent protein kinase regulator activity nucleus|cytoplasm
YFR041C YFR041C ERJ5 hom Verified 0.793297871484162 0.21380214832836 no 1009 0.19759440117259 698 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Type I membrane protein with a J domain is required to preserve the folding capacity of the endoplasmic reticulum; loss of the non-essential ERJ5 gene leads to a constitutively induced unfolded protein response protein folding molecular_function endoplasmic reticulum
YLR304C YLR304C ACO1 hom Verified 0.791909732534978 0.214206655832109 no 1010 0.277672200603451 976 NA FF|FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION Aconitase, required for the tricarboxylic acid (TCA) cycle and also independently required for mitochondrial genome maintenance; phosphorylated; component of the mitochondrial nucleoid; mutation leads to glutamate auxotrophy propionate metabolic process|glutamate biosynthetic process|tricarboxylic acid cycle|mitochondrial genome maintenance|citrate metabolic process double-stranded DNA binding|aconitate hydratase activity|single-stranded DNA binding mitochondrial nucleoid|cytosol|mitochondrion|mitochondrial matrix
YMR322C_p YMR322C SNO4 hom Uncharacterized 0.791626579552242 0.214289222031275 no 1011 0.177138197936734 556 NA FT PROTEOLYSIS Possible chaperone and cysteine protease, similar to bacterial Hsp31 and yeast Hsp31p, Hsp32p, and Hsp33p; DJ-1/ThiJ/PfpI superfamily member; predicted involvement in pyridoxine metabolism; induced by mild heat stress and copper deprivation biological_process cysteine-type peptidase activity cellular_component
YDR306C_p YDR306C YDR306C hom Uncharacterized 0.791565653262023 0.214306990296924 no 1012 0.231692735422012 773 NA FT PROTEOLYSIS F-box protein of unknown function; interacts with Sgt1p via a Leucine-Rich Repeat (LRR) domain SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ubiquitin-protein ligase activity|protein binding, bridging SCF ubiquitin ligase complex
YMR297W YMR297W PRC1 hom Verified 0.791009520995144 0.214469217784619 no 1013 0.176533107838602 615 NA FT PROTEOLYSIS ENDOPLASMIC RETICULUM Vacuolar carboxypeptidase Y (proteinase C; CPY), broad-specificity C-terminal exopeptidase involved in non-specific protein degradation in the vacuole; member of the serine carboxypeptidase family vacuolar protein catabolic process|phytochelatin biosynthetic process serine-type carboxypeptidase activity fungal-type vacuole lumen|endoplasmic reticulum|fungal-type vacuole|cytoplasm
YML082W_p YML082W YML082W hom Uncharacterized 0.790868012514486 0.214510508144235 no 1014 0.244924230792347 844 NA FT KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS Putative protein predicted to have carbon-sulfur lyase activity; transcriptionally regulated by Upc2p via an upstream sterol response element; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and the cytoplasm; YML082W is not an essential gene sulfur compound metabolic process carbon-sulfur lyase activity nucleus|cytoplasm
YNL071W YNL071W LAT1 hom Verified 0.790776658838182 0.214537166429913 no 1015 0.235363742506058 762 NA FT KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION Dihydrolipoamide acetyltransferase component (E2) of pyruvate dehydrogenase complex, which catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA acetyl-CoA biosynthetic process from pyruvate dihydrolipoyllysine-residue acetyltransferase activity mitochondrion|mitochondrial pyruvate dehydrogenase complex
YGR008C YGR008C STF2 hom Verified 0.789881987340678 0.214798345912521 no 1016 0.214362815684531 718 NA FT MITOCHONDRION Protein involved in resistance to dessication stress; Stf2p exhibits antioxidant properties, and its overexpression prevents ROS accumulation and apoptosis; binds to the F0 sector of mitochondrial F1F0 ATPase in vitro and is proposed to modulate the inhibitory action of Inh1p and Stf1p; protein abundance increases in response to DNA replication stress cellular response to desiccation molecular_function cytoplasm
YDR223W YDR223W CRF1 hom Verified 0.78929771931395 0.214969009658124 no 1017 0.215121191663684 709 NA FT TRANSCRIPTION FROM RNA POL II|RIBOSOME BIOGENESIS NUCLEUS|CHROMOSOME Transcriptional corepressor involved in repression of ribosomal protein (RP) gene transcription via the TOR signaling pathway which promotes accumulation of Crf1p in the nucleus; role in repression of RP genes varies by strain negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter transcription corepressor activity nuclear chromatin|nucleus|cytoplasm
YBR012C_d YBR012C YBR012C hom Dubious 0.788808874469598 0.215111860933653 no 1018 0.214487109726804 670 NA Dubious open reading frame, unlikely to encode a functional protein; expression induced by iron-regulated transcriptional activator Aft2p Unknown Unknown Unknown
YBR178W_d YBR178W YBR178W hom Dubious 0.788467265222944 0.215211719414543 no 1019 0.223031172832013 732 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR177C Unknown Unknown Unknown
YDR090C_p YDR090C YDR090C hom Uncharacterized 0.788115528177152 0.215314566540247 no 1020 0.236728090949148 821 NA FT PLASMA MEMBRANE Putative protein of unknown function biological_process molecular_function integral to membrane
YJL127C-B_p YJL127C-B YJL127C-B hom Uncharacterized 0.787334408708666 0.215543066092527 no 1021 0.19799132668063 668 NA Putative protein of unknown function; identified based on homology to the filamentous fungus, Ashbya gossypii biological_process molecular_function cellular_component
YLR393W YLR393W ATP10 hom Verified 0.787123939421908 0.215604658358864 no 1022 0.210095454904623 677 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial inner membrane protein required for assembly of the F0 sector of mitochondrial F1F0 ATP synthase, interacts genetically with ATP6 mitochondrial proton-transporting ATP synthase complex assembly unfolded protein binding integral to mitochondrial membrane|mitochondrion|mitochondrial inner membrane
YGR273C_p YGR273C YGR273C hom Uncharacterized 0.786875928156159 0.215677250102364 no 1023 0.223478937349365 755 NA Putative protein of unknown function; expression downregulated by treatment with 8-methoxypsoralen plus UVA irradiation; YGR273C is not an essential gene biological_process molecular_function cellular_component
YNL144C_p YNL144C YNL144C hom Uncharacterized 0.786712890153273 0.215724978285527 no 1024 0.206030588831084 685 NA FT MITOCHONDRION Putative protein of unknown function; non-tagged protein is detected in highly purified mitochondria in high-throughput studies; contains a PH domain and binds phosphatidylinositols and phosphatidylethanolamine in a large-scale study biological_process molecular_function mitochondrion
YDR270W YDR270W CCC2 hom Verified 0.784919863853693 0.216250277413442 no 1025 0.248637690690137 879 NA FF|FT ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Cu(+2)-transporting P-type ATPase; required for export of copper from the cytosol into an extracytosolic compartment; has similarity to human proteins involved in Menkes and Wilsons diseases; protein abundance increases in response to DNA replication stress; affects TBSV model (+)RNA virus replication by regulating copper metabolism cellular iron ion homeostasis|copper ion export|transmembrane transport copper ion binding|cation-transporting ATPase activity integral to membrane|trans-Golgi network transport vesicle membrane
YMR105W-A_p YMR105W-A YMR105W-A hom Uncharacterized 0.782821967111383 0.216865832943243 no 1026 0.253327598910161 886 NA Putative protein of unknown function biological_process molecular_function cellular_component
YDR422C YDR422C SIP1 hom Verified 0.782774107743203 0.216879887433895 no 1027 0.213857167149001 696 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|SIGNALING|PROTEIN PHOSPHORYLATION Alternate beta-subunit of the Snf1p kinase complex, may confer substrate specificity; vacuolar protein containing KIS (Kinase-Interacting Sequence) and ASC (Association with Snf1 kinase Complex) domains involved in protein interactions signal transduction|protein phosphorylation|regulation of protein complex assembly AMP-activated protein kinase activity AMP-activated protein kinase complex|fungal-type vacuole
YOR147W YOR147W MDM32 hom Verified 0.782759673030688 0.216884126467676 no 1028 0.212414045287389 758 NA FT ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS MITOCHONDRION Mitochondrial inner membrane protein with similarity to Mdm31p, required for normal mitochondrial morphology and inheritance; interacts genetically with MMM1, MDM10, MDM12, and MDM34 mitochondrion inheritance|cellular ion homeostasis|mitochondrion organization molecular_function mitochondrion|mitochondrial inner membrane
YBR292C_d YBR292C YBR292C hom Dubious 0.782749473770417 0.216887121707493 no 1029 0.211836934602169 777 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR292C is not an essential gene Unknown Unknown Unknown
YHL035C YHL035C VMR1 hom Verified 0.782177077534513 0.217055256928786 no 1030 0.224724594427703 769 NA FT NUCLEOTIDE METABOLISM MITOCHONDRION Vacuolar membrane protein involved in multiple drug resistance and metal sensitivity; ATP-binding cassette (ABC) family member involved in drug transport; potential Cdc28p substrate; induced under respiratory conditions transport|response to drug|response to metal ion|drug transport ATPase activity, coupled to transmembrane movement of substances fungal-type vacuole membrane|mitochondrion|integral to membrane|ribosome
YBL068W YBL068W PRS4 hom Verified 0.780839040026607 0.217448584700074 no 1031 0.174817654897569 598 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; PRS4 has a paralog, PRS2, that arose from the whole genome duplication fungal-type cell wall organization|5-phosphoribose 1-diphosphate biosynthetic process ribose phosphate diphosphokinase activity cytoplasm
YMR256C YMR256C COX7 hom Verified 0.779512170535696 0.217839035563346 no 1032 0.245968679442498 831 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Subunit VII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain mitochondrial electron transport, cytochrome c to oxygen cytochrome-c oxidase activity mitochondrion|integral to membrane|mitochondrial respiratory chain complex IV
YKR047W_d YKR047W YKR047W hom Dubious 0.779379586626773 0.217878072537317 no 1033 0.241867779928802 809 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NAP1 Unknown Unknown Unknown
YDR509W_d YDR509W YDR509W hom Dubious 0.77936982607269 0.217880946518298 no 1034 0.214404298989179 767 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YGR034W YGR034W RPL26B hom Verified 0.779047051250458 0.217975999411287 no 1035 0.236837638238016 795 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L26B; binds to 5.8S rRNA; homologous to mammalian ribosomal protein L26 and bacterial L24; RPL26B has a paralog, RPL26A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome|RNA binding cytosolic large ribosomal subunit
YDL200C YDL200C MGT1 hom Verified 0.778823840817442 0.21804174589722 no 1036 0.239171468970537 784 NA FT RESPONSE TO DNA DAMAGE NUCLEUS DNA repair methyltransferase (6-O-methylguanine-DNA methylase) involved in protection against DNA alkylation damage DNA dealkylation involved in DNA repair methylated-DNA-[protein]-cysteine S-methyltransferase activity nucleus
YNL135C YNL135C FPR1 hom Verified 0.778680453667636 0.218083986517602 no 1037 0.234707522123338 812 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|CHROMATIN ORGANIZATION NUCLEUS|MITOCHONDRION Peptidyl-prolyl cis-trans isomerase (PPIase), binds to the drugs FK506 and rapamycin; also binds to the nonhistone chromatin binding protein Hmo1p and may regulate its assembly or function protein folding|chromatin organization|homoserine metabolic process peptidyl-prolyl cis-trans isomerase activity|macrolide binding mitochondrion|nucleus|cytoplasm
YPR069C YPR069C SPE3 hom Verified 0.778132256781842 0.218245524086118 no 1038 0.251896884370818 877 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM NUCLEUS Spermidine synthase, involved in biosynthesis of spermidine and also in biosynthesis of pantothenic acid; spermidine is required for growth of wild-type cells spermidine biosynthetic process|pantothenate biosynthetic process spermidine synthase activity nucleus|cytoplasm
YIL058W_d YIL058W YIL058W hom Dubious 0.77733913393333 0.218479356148674 no 1039 0.222803542123514 765 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YNL286W YNL286W CUS2 hom Verified 0.777239071496362 0.218508867254255 no 1040 0.222303025769652 734 NA FT RNA PROCESSING NUCLEUS Protein that binds to U2 snRNA and Prp11p, may be involved in U2 snRNA folding; contains two RNA recognition motifs (RRMs) mRNA splicing, via spliceosome RNA binding U2 snRNP
YMR316W YMR316W DIA1 hom Verified 0.777194955552733 0.218521878962343 no 1041 0.236698434825596 814 NA Protein of unknown function, involved in invasive and pseudohyphal growth; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern pseudohyphal growth|invasive growth in response to glucose limitation molecular_function cytoplasm
YHR017W YHR017W YSC83 hom Verified 0.777061817566281 0.218561149842623 no 1042 0.245866754460991 891 NA FT MITOCHONDRION Non-essential mitochondrial protein of unknown function; mRNA induced during meiosis, peaking between mid to late prophase of meiosis I; similar to S. douglasii YSD83 biological_process molecular_function mitochondrial outer membrane|mitochondrion
YKR016W YKR016W FCJ1 hom Verified 0.775423152790283 0.219044829224301 no 1043 0.207060501538255 684 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial inner membrane protein, ortholog of mammalian mitofilin; involved in import of intermembrane space (IMS) proteins, probably by positioning Mia40p relative to the TOM complex to receive incoming proteins; also has an essential role in the maintenance of crista junctions and inner membrane architecture, as a component of the mitochondrial inner membrane organizing system (MICOS, MitOS or MINOS), a scaffold-like structure on the IMS side of the inner membrane cristae formation|protein import into mitochondrial intermembrane space molecular_function mitochondrion|mitochondrial inner membrane|mitochondrial crista|mitochondrial crista junction|integral to mitochondrial inner membrane
YAR018C YAR018C KIN3 hom Verified 0.774415219225803 0.219342643219866 no 1044 0.238281138255006 797 NA FT PROTEIN PHOSPHORYLATION|CHROMOSOME SEGREGATION Nonessential serine/threonine protein kinase; possible role in DNA damage response chromosome segregation|protein phosphorylation protein kinase activity cellular_component
YBL008W-A_p YBL008W-A YBL008W-A hom Uncharacterized 0.773951345364513 0.219479782115709 no 1045 0.212406703436645 756 NA Putative protein of unknown function; identified by fungal homology and RT-PCR biological_process molecular_function cellular_component
YJR049C YJR049C UTR1 hom Verified 0.773616254471742 0.219578878464516 no 1046 0.245954513684634 830 NA FF|FT ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS|COFACTOR METABOLISM NUCLEUS ATP-NADH kinase; phosphorylates both NAD and NADH; active as a hexamer; enhances the activity of ferric reductase (Fre1p); UTR1 has a paralog, YEF1, that arose from the whole genome duplication cellular iron ion homeostasis|NADP biosynthetic process NAD+ kinase activity|NADH kinase activity nucleus|cytoplasm
YML110C YML110C COQ5 hom Verified 0.773349256026936 0.219657856241821 no 1047 0.244887573780273 825 NA FT KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION 2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase, involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes ubiquinone biosynthetic process|aerobic respiration 2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity mitochondrion|mitochondrial matrix
YDR042C_p YDR042C YDR042C hom Uncharacterized 0.772869094866699 0.219799928297377 no 1048 0.193170829446375 628 NA Putative protein of unknown function; expression is increased in ssu72-ts69 mutant biological_process molecular_function cellular_component
YDR261C YDR261C EXG2 hom Verified 0.771569445039137 0.220184738518917 no 1049 0.205710931943995 709 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM PLASMA MEMBRANE Exo-1,3-beta-glucanase, involved in cell wall beta-glucan assembly; may be anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor fungal-type cell wall organization glucan exo-1,3-beta-glucosidase activity fungal-type cell wall
YDR218C YDR218C SPR28 hom Verified 0.771545028190561 0.220191971741 no 1050 0.199617317955172 673 NA FT CELL CYCLE|CELL DIVISION SITE OF POLARIZED GROWTH|CYTOSKELETON Sporulation-specific homolog of the yeast CDC3/10/11/12 family of bud neck microfilament genes; meiotic septin expressed at high levels during meiotic divisions and ascospore formation sexual sporulation resulting in formation of a cellular spore structural molecule activity spindle microtubule|meiotic spindle|septin complex|prospore membrane|ascospore wall
YML121W YML121W GTR1 hom Verified 0.771334865148813 0.220254235858025 no 1051 0.263368736213943 920 NA FF|FT PROTEIN LOCALIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS|GENE SILENCING NUCLEUS Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB phosphate ion transport|transcription from RNA polymerase I promoter|transcription from RNA polymerase III promoter|chromatin silencing at telomere GDP binding|GTP binding fungal-type vacuole membrane|EGO complex|nucleus|late endosome membrane|cytoplasm
YMR177W YMR177W MMT1 hom Verified 0.771218826466701 0.22028861847383 no 1052 0.221851440020164 787 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION Putative metal transporter involved in mitochondrial iron accumulation; closely related to Mmt2p cellular iron ion homeostasis molecular_function mitochondrion|integral to membrane
YFL023W YFL023W BUD27 hom Verified 0.769691642880157 0.220741414304028 no 1053 0.222123108360869 824 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION RIBOSOME Unconventional prefoldin protein involved in translation initiation; mutants have inappropriate expression of nutrient sensitive genes due to translational derepression of Gcn4p transcription factor; diploid mutants show random budding; ortholog of human URI/RMP formation of translation preinitiation complex molecular_function cytosolic ribosome|cytoplasm
YLR180W YLR180W SAM1 hom Verified 0.769391383015192 0.220830501240874 no 1054 0.206701041294131 693 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM S-adenosylmethionine synthetase; catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; SAM1 has a paralog, SAM2, that arose from the whole genome duplication methionine metabolic process|S-adenosylmethionine biosynthetic process methionine adenosyltransferase activity cytoplasm
YPR118W YPR118W MRI1 hom Verified 0.768776682992893 0.221012946598084 no 1055 0.232684367365866 767 NA FT KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS 5'-methylthioribose-1-phosphate isomerase; catalyzes the isomerization of 5-methylthioribose-1-phosphate to 5-methylthioribulose-1-phosphate in the methionine salvage pathway L-methionine salvage from methylthioadenosine S-methyl-5-thioribose-1-phosphate isomerase activity nucleus|cytoplasm
YPL046C YPL046C ELC1 hom Verified 0.768065474027308 0.22122414379332 no 1056 0.193286385885615 681 NA FT RESPONSE TO DNA DAMAGE|PROTEOLYSIS NUCLEUS UBIQUITIN LIGASE COMPLEX Elongin C, conserved among eukaryotes; forms a complex with Cul3p that polyubiquitylates monoubiquitylated RNA polymerase II to trigger its proteolysis; plays a role in global genomic repair global genome nucleotide-excision repair|protein ubiquitination involved in ubiquitin-dependent protein catabolic process ubiquitin-protein ligase activity elongin complex|Cul3-RING ubiquitin ligase complex
YOL153C YOL153C YOL153C hom pseudogene 0.767194903799837 0.221482821220657 no 1057 0.186590700442285 612 NA Hypothetical protein biological_process molecular_function cellular_component
YOR188W YOR188W MSB1 hom Verified 0.767166115713669 0.221491378139065 no 1058 0.264043989074288 949 NA FT MITOCHONDRION|SITE OF POLARIZED GROWTH Protein of unknown function; may be involved in positive regulation of 1,3-beta-glucan synthesis and the Pkc1p-MAPK pathway; multicopy suppressor of temperature-sensitive mutations in CDC24 and CDC42, and of mutations in BEM4; potential Cdc28p substrate; relocalizes from bud neck to cytoplasm upon DNA replication stress establishment of cell polarity molecular_function mitochondrion|cellular bud neck|cellular bud tip
YLR092W YLR092W SUL2 hom Verified 0.766005677308152 0.2218364620556 no 1059 0.21700891041866 742 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE High affinity sulfate permease; sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p, which control the concentration of endogenous activated sulfate intermediates sulfate transport sulfate transmembrane transporter activity integral to membrane|plasma membrane
YLR054C YLR054C OSW2 hom Verified 0.765685757597356 0.221931651750978 no 1060 0.227685885062946 768 NA FT CELL WALL ORG/BIOGENESIS Protein of unknown function proposed to be involved in the assembly of the spore wall ascospore wall assembly molecular_function integral to membrane|prospore membrane|cytoplasm
YGL088W_d YGL088W YGL088W hom Dubious 0.765332468546196 0.222036797337407 no 1061 0.222510185970765 731 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps snR10, a snoRNA required for preRNA processing Unknown Unknown Unknown
YDL227C YDL227C HO hom Verified 0.764027356506975 0.22242547016241 no 1062 0.184364389476903 629 NA FT NUCLEUS Site-specific endonuclease required for gene conversion at the MAT locus (homothallic switching) through the generation of a ds DNA break; expression restricted to mother cells in late G1 as controlled by Swi4p-Swi6p, Swi5p and Ash1p mating type switching|gene conversion at mating-type locus, DNA double-strand break formation endonuclease activity nucleus
YAL042C-A_d YAL042C-A YAL042C-A hom Dubious 0.763734990458997 0.222512592285484 no 1063 0.223336118573854 762 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF ERV46/YAL042W; YAL042C-A is a non-essential gene Unknown Unknown Unknown
YAL067W-A_p YAL067W-A YAL067W-A hom Uncharacterized 0.76368853672109 0.222526436820505 no 1064 0.205913927545719 694 NA Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching biological_process molecular_function cellular_component
YCR037C YCR037C PHO87 hom Verified 0.763655670104607 0.222536232303613 no 1065 0.226732372525176 795 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS Low-affinity inorganic phosphate (Pi) transporter; involved in activation of PHO pathway; expression is independent of Pi concentration and Pho4p activity; contains 12 membrane-spanning segments; PHO87 has a paralog, PHO90, that arose from the whole genome duplication phosphate ion transport|transmembrane transport inorganic phosphate transmembrane transporter activity integral to membrane|membrane
YBL099W YBL099W ATP1 hom Verified 0.763633832969612 0.222542740723945 no 1066 0.23466746745901 853 NA FT ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS MITOCHONDRION Alpha subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated ATP synthesis coupled proton transport hydrogen ion transporting ATP synthase activity, rotational mechanism|ATPase activity|proton-transporting ATPase activity, rotational mechanism mitochondrial nucleoid|proton-transporting ATP synthase complex, catalytic core F(1)|mitochondrion|integral to membrane|mitochondrial proton-transporting ATP synthase, catalytic core
YMR184W YMR184W ADD37 hom Verified 0.762450703832523 0.222895527100948 no 1067 0.221253214479789 731 NA FT PROTEOLYSIS Protein of unknown function; involved in ER-associated protein degradation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YMR184W is not an essential gene; protein abundance increases in response to DNA replication stress ER-associated protein catabolic process molecular_function cytoplasm
YGR208W YGR208W SER2 hom Verified 0.762238120301798 0.222958949174339 no 1068 0.210104544659533 714 NA FT KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS Phosphoserine phosphatase of the phosphoglycerate pathway, involved in serine and glycine biosynthesis, expression is regulated by the available nitrogen source L-serine biosynthetic process phosphoserine phosphatase activity nucleus|cytoplasm
YML007W YML007W YAP1 hom Verified 0.762112237832739 0.222996509737622 no 1069 0.245974703127335 831 NA FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO OXIDATIVE STRESS NUCLEUS Basic leucine zipper (bZIP) transcription factor; required for oxidative stress tolerance; activated by H2O2 through the multistep formation of disulfide bonds and transit from the cytoplasm to the nucleus; Yap1p is degraded in the nucleus after the oxidative stress has passed; mediates resistance to cadmium; YAP1 has a paralog, CAD1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance|response to heat|response to drug|response to singlet oxygen|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|response to metal ion sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity nucleus|cytoplasm
YBR301W YBR301W PAU24 hom Verified 0.761891647997233 0.223062337588514 no 1070 0.213311169741319 722 NA FT CELL WALL ORG/BIOGENESIS Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; member of the seripauperin multigene family encoded mainly in subtelomeric regions; expressed under anaerobic conditions, completely repressed during aerobic growth biological_process molecular_function fungal-type cell wall
YEL027W YEL027W VMA3 hom Verified 0.761715124879207 0.223115023132728 no 1071 0.241150748956038 788 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS|VACUOLAR TRANSPORT Proteolipid subunit of the vacuolar H(+)-ATPase V0 sector (subunit c; dicyclohexylcarbodiimide binding subunit); required for vacuolar acidification and important for copper and iron metal ion homeostasis cellular copper ion homeostasis|cellular iron ion homeostasis|endocytosis|vacuole organization|proton transport|vacuolar acidification|protein targeting to vacuole hydrogen ion transmembrane transporter activity vacuolar proton-transporting V-type ATPase, V0 domain|integral to membrane
YKL211C YKL211C TRP3 hom Verified 0.761401344799191 0.223208692231977 no 1072 0.419171580709559 1390 NA FF|FT KETONE METABOLISM|AMINO ACID METABOLISM Indole-3-glycerol-phosphate synthase; forms bifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p tryptophan biosynthetic process indole-3-glycerol-phosphate synthase activity|anthranilate synthase activity anthranilate synthase complex|cytoplasm
YDR199W_d YDR199W YDR199W hom Dubious 0.761231379587671 0.223259439305039 no 1073 0.249062095555887 877 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VPS64; computationally predicted to have thiol-disulfide oxidoreductase activity Unknown Unknown Unknown
YCR060W YCR060W TAH1 hom Verified 0.761181617040007 0.223274298315501 no 1074 0.212628327360075 692 NA FT PROTEIN COMPLEX ORG/BIOGENESIS NUCLEUS Component of the conserved R2TP complex (Rvb1-Rvb2-Tah1-Pih1); contains a single TPR domain with at least two TPR motifs; R2TP complex interacts with Hsp90 (Hsp82p and Hsc82p) to mediate assembly large protein complexes such as box C/D snoRNPs and RNA polymerase II protein folding|box C/D snoRNP assembly chaperone binding R2TP complex|nucleus|cytoplasm
YOL013W-A_p YOL013W-A YOL013W-A hom Uncharacterized 0.759561108476508 0.223758486878121 no 1075 0.222416272824807 749 NA Putative protein of unknown function; identified by SAGE biological_process molecular_function integral to membrane
YLR406C YLR406C RPL31B hom Verified 0.759461174775224 0.223788365399043 no 1076 0.257882475192615 892 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L31B; associates with karyopherin Sxm1p; loss of both Rpl31p and Rpl39p confers lethality; homologous to mammalian ribosomal protein L31, no bacterial homolog; RPL31B has a paralog, RPL31A, that arose from the whole genome duplication cytoplasmic translation|regulation of translational fidelity structural constituent of ribosome cytosolic large ribosomal subunit
YIL149C YIL149C MLP2 hom Verified 0.75867146937442 0.224024553985403 no 1077 0.203312969468766 677 NA FT PROTEIN LOCALIZATION|CELL CYCLE|CYTOSKELETON ORGANIZATION|RNA LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION|CYTOSKELETON Myosin-like protein associated with the nuclear envelope, connects the nuclear pore complex with the nuclear interior; involved in the Tel1p pathway that controls telomere length poly(A)+ mRNA export from nucleus|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|regulation of transcription, DNA-dependent|telomere tethering at nuclear periphery|spindle pole body organization|transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery ribonucleoprotein complex binding nucleoplasm|nuclear envelope|mitochondrion|ribonucleoprotein complex|integral to membrane|spindle pole body
YKL119C YKL119C VPH2 hom Verified 0.75703798819032 0.224513551905808 no 1078 0.232395893682621 780 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|ION HOMEOSTASIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Integral membrane protein required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the endoplasmic reticulum (ER) vacuolar proton-transporting V-type ATPase complex assembly|vacuolar acidification molecular_function endoplasmic reticulum membrane
YFR040W YFR040W SAP155 hom Verified 0.756459564664142 0.22468685350943 no 1079 0.234906872185978 819 NA FT CELL CYCLE Protein required for function of the Sit4p protein phosphatase; forms a complex with Sit4p; member of a family of similar proteins including Sap4p, Sap185p, and Sap190p; protein abundance increases in response to DNA replication stress G1/S transition of mitotic cell cycle protein serine/threonine phosphatase activity cytoplasm
YDL054C YDL054C MCH1 hom Verified 0.755174192330726 0.225072235709518 no 1080 0.230936105868404 796 NA Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport transport monocarboxylic acid transmembrane transporter activity|transporter activity integral to membrane|membrane
YDL001W YDL001W RMD1 hom Verified 0.754794560714723 0.225186129016986 no 1081 0.217203034859021 778 NA FT CELL CYCLE Cytoplasmic protein required for sporulation biological_process molecular_function cytoplasm
YKL096W YKL096W CWP1 hom Verified 0.754591971752277 0.225246921102851 no 1082 0.205992187131374 698 NA FT MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS Cell wall mannoprotein that localizes specifically to birth scars of daughter cells, linked to a beta-1,3- and beta-1,6-glucan heteropolymer through a phosphodiester bond; required for propionic acid resistance fungal-type cell wall organization|ascospore-type prospore membrane assembly structural constituent of cell wall fungal-type cell wall|cellular birth scar|prospore membrane
YBR221C YBR221C PDB1 hom Verified 0.753475040735799 0.225582252141646 no 1083 0.202597177892055 687 NA FT KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION E1 beta subunit of the pyruvate dehydrogenase (PDH) complex, which is an evolutionarily-conserved multi-protein complex found in mitochondria acetyl-CoA biosynthetic process from pyruvate pyruvate dehydrogenase (acetyl-transferring) activity mitochondrial nucleoid|mitochondrion|mitochondrial pyruvate dehydrogenase complex
YER107C YER107C GLE2 hom Verified 0.75328273054814 0.225640017035743 no 1084 0.279691316029448 976 NA FF|FT PROTEIN LOCALIZATION|RNA LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS NUCLEAR PORE RNA export factor associated with the nuclear pore complex (NPC); associates with NUP116p; required for polyadenylated RNA export but not for protein import; homologous to S. pombe Rae1p and human RAE1 poly(A)+ mRNA export from nucleus|Unknown|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|nuclear pore distribution|transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery molecular_function integral to membrane|nuclear pore|cytoplasm
YOR297C YOR297C TIM18 hom Verified 0.75291771004439 0.225749682557282 no 1085 0.192956901701847 651 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS MITOCHONDRION Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; may mediate assembly or stability of the complex cellular response to oxidative stress|protein import into mitochondrial inner membrane|apoptotic process|response to acid|response to osmotic stress|response to arsenic-containing substance protein channel activity mitochondrion|integral to membrane|mitochondrial inner membrane protein insertion complex
YDL243C YDL243C AAD4 hom Verified 0.751394093925164 0.226207758043953 no 1086 0.218057837860011 730 NA FT OXIDATION-REDUCTION PROCESS Putative aryl-alcohol dehydrogenase; involved in oxidative stress response; similar to P. chrysosporium aryl-alcohol dehydrogenase; expression induced in cells treated with the mycotoxin patulin cellular aldehyde metabolic process aryl-alcohol dehydrogenase (NAD+) activity cellular_component
YKL070W_p YKL070W YKL070W hom Uncharacterized 0.751246383084142 0.226252195245966 no 1087 0.196908639949466 657 NA FT OXIDATION-REDUCTION PROCESS MITOCHONDRION Putative protein of unknown function; expression induced in cells treated with mycotoxins patulin or citrinin; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process molecular_function mitochondrion
YJR005W YJR005W APL1 hom Verified 0.75010195452026 0.226596651228304 no 1088 0.223465979480246 785 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|PLASMA MEMBRANE Beta-adaptin, large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport; similar to mammalian beta-chain of the clathrin associated protein complex vesicle-mediated transport molecular_function AP-2 adaptor complex
YCR053W YCR053W THR4 hom Verified 0.749363746469791 0.226818997840253 no 1089 0.200708726709469 658 NA FT VESICLE-MEDIATED TRANSPORT|KETONE METABOLISM|MEMBRANE ORGANIZATION|AMINO ACID METABOLISM NUCLEUS Threonine synthase, conserved protein that catalyzes formation of threonine from O-phosphohomoserine; expression is regulated by the GCN4-mediated general amino acid control pathway endocytosis|threonine metabolic process threonine synthase activity nucleus|cytoplasm
YDR058C YDR058C TGL2 hom Verified 0.749284693785958 0.226842815625655 no 1090 0.232657629358245 801 NA FT PROTEIN LOCALIZATION|LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION Triacylglycerol lipase that is localized to the mitochondria; has lipolytic activity towards triacylglycerols and diacylglycerols when expressed in E. coli triglyceride catabolic process triglyceride lipase activity mitochondrion
YER186C_p YER186C YER186C hom Uncharacterized 0.749052200710359 0.226912871646996 no 1091 0.224615883326353 772 NA Putative protein of unknown function biological_process molecular_function cellular_component
YMR284W YMR284W YKU70 hom Verified 0.747583155376537 0.227355814069409 no 1092 0.203885142040498 710 NA FT CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING ENDOMEMBRANE SYSTEM|NUCLEUS|CHROMOSOME Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair chromatin assembly or disassembly|chromatin silencing|double-strand break repair via nonhomologous end joining|telomere maintenance|double-strand break repair via break-induced replication|double-strand break repair via homologous recombination|chromatin silencing at silent mating-type cassette damaged DNA binding|RNA binding nuclear chromatin|nuclear telomeric heterochromatin|nuclear envelope|Ku70:Ku80 complex
YKR105C_p YKR105C VBA5 hom Uncharacterized 0.745277142332883 0.228052098152435 no 1093 0.223451743161573 767 NA Plasma membrane protein of the Major Facilitator Superfamily (MFS); involved in amino acid uptake and drug sensitivity; similar to Vba3p biological_process molecular_function integral to membrane
YGL198W YGL198W YIP4 hom Verified 0.744812103067219 0.228192658590746 no 1094 0.241780654725254 808 NA FT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Protein that interacts with Rab GTPases, localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport biological_process Rab GTPase binding integral to membrane|Golgi apparatus
YDR096W YDR096W GIS1 hom Verified 0.744751853262241 0.228210872958228 no 1095 0.22034525915948 717 NA FT TRANSCRIPTION FROM RNA POL II|LIPID METABOLISM|CHROMATIN ORGANIZATION|RESPONSE TO NUTRIENT LEVELS NUCLEUS|MITOCHONDRION Histone demethylase and transcription factor; regulates genes during nutrient limitation; negatively regulates DPP1, PHR1; activity modulated by limited proteasome-mediated proteolysis; has JmjC and JmjN domain in N-terminal region that interact, promoting stability and proper transcriptional activity; contains two transactivating domains downstream of Jmj domains and a C-terminal DNA binding domain; GIS1 has a paralog, RPH1, that arose from the whole genome duplication negative regulation of transcription from RNA polymerase II promoter|chronological cell aging|regulation of phospholipid biosynthetic process|histone demethylation|positive regulation of transcription from RNA polymerase II promoter|maintenance of stationary phase in response to starvation RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|histone demethylase activity (H3-K36 specific) mitochondrion|nucleus
YKL068W-A_p YKL068W-A YKL068W-A hom Uncharacterized 0.74454974408674 0.228271979387389 no 1096 0.275436612103136 977 NA Putative protein of unknown function; identified by homology to Ashbya gossypii biological_process molecular_function cellular_component
YKL142W YKL142W MRP8 hom Verified 0.743471012336517 0.228598282599775 no 1097 0.223856887530602 754 NA Protein of unknown function; undergoes sumoylation; transcription induced under cell wall stress; protein levels are reduced under anaerobic conditions; protein abundance increases in response to DNA replication stress; originally thought to be a mitochondrial ribosomal protein based on sequence analysis biological_process molecular_function cytoplasm
YDR034W-B_p YDR034W-B YDR034W-B hom Uncharacterized 0.74313439781594 0.228700157992732 no 1098 0.235580129373128 788 NA Predicted tail-anchored plasma membrane protein containing a conserved CYSTM module; related proteins in other organisms may be involved in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery biological_process molecular_function cellular_component
YPR005C YPR005C HAL1 hom Verified 0.742985855953534 0.228745121855184 no 1099 0.229465624604001 795 NA FT TRANSCRIPTION FROM RNA POL II Cytoplasmic protein involved in halotolerance; decreases intracellular Na+ (via Ena1p) and increases intracellular K+ by decreasing efflux; expression repressed by Ssn6p-Tup1p and Sko1p and induced by NaCl, KCl, and sorbitol through Gcn4p response to salt stress|positive regulation of transcription from RNA polymerase II promoter molecular_function cytoplasm
YNL130C-A_p YNL130C-A DGR1 hom Uncharacterized 0.742170371207739 0.228992058805836 no 1100 0.211454832145521 740 NA FT MITOCHONDRION Protein of unknown function; dgr1 null mutant is resistant to 2-deoxy-D-glucose biological_process molecular_function cellular_component
YJL070C_p YJL070C YJL070C hom Uncharacterized 0.741897821822789 0.229074622825808 no 1101 0.18157051351662 624 NA FT NUCLEOTIDE METABOLISM MITOCHONDRION Putative metallo-dependent hydrolase superfamily protein; similar to AMP deaminases but lacks key catalytic residues and does not rescue purine nucleotide metabolic defect of quadruple aah1 ade8 amd1 his1 mutant; may regulate purine nucleotide homeostasis as overexpression in an AMD1 strain grown in adenine results in greatly reduced GDP and GTP intracellular levels; not an essential gene; YJL070C has a paralog, YBR284W, that arose from the whole genome duplication biological_process AMP deaminase activity|molecular_function mitochondrion|cytoplasm
YIL035C YIL035C CKA1 hom Verified 0.741776855033769 0.229111272926848 no 1102 0.230837729491632 795 NA FT RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION NUCLEUS Alpha catalytic subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases; regulates Fkh1p-mediated donor preference during mating-type switching regulation of transcription from RNA polymerase I promoter|protein phosphorylation|regulation of transcription from RNA polymerase III promoter|response to DNA damage stimulus protein serine/threonine kinase activity|protein kinase activity protein kinase CK2 complex|UTP-C complex
YDR256C YDR256C CTA1 hom Verified 0.741444360725045 0.229212027849649 no 1103 0.22318025198685 754 NA FT OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS MITOCHONDRION Catalase A, breaks down hydrogen peroxide in the peroxisomal matrix formed by acyl-CoA oxidase (Pox1p) during fatty acid beta-oxidation response to reactive oxygen species|age-dependent response to reactive oxygen species|hydrogen peroxide catabolic process catalase activity peroxisomal matrix|mitochondrial matrix
YML128C YML128C MSC1 hom Verified 0.741409606900386 0.229222560648711 no 1104 0.238672024638367 778 NA FT CELL CYCLE ENDOPLASMIC RETICULUM|MITOCHONDRION Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria and is phosphorylated reciprocal meiotic recombination molecular_function mitochondrion|endoplasmic reticulum|plasma membrane
YML021C YML021C UNG1 hom Verified 0.740887625218036 0.229380789644174 no 1105 0.229630606487253 808 NA FT RESPONSE TO DNA DAMAGE NUCLEUS|MITOCHONDRION Uracil-DNA glycosylase, required for repair of uracil in DNA formed by spontaneous cytosine deamination, not required for strand-specific mismatch repair, cell-cycle regulated, expressed in late G1, localizes to mitochondria and nucleus DNA repair uracil DNA N-glycosylase activity mitochondrion|nucleus
YGR163W YGR163W GTR2 hom Verified 0.740628358072222 0.229459404386683 no 1106 0.272833750625672 950 NA FF|FT PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|MEMBRANE ORGANIZATION NUCLEUS|CHROMOSOME Putative GTP binding protein that negatively regulates Ran/Tc4 GTPase cycle; activates transcription; subunit of EGO and GSE complexes; required for sorting of Gap1p; localizes to cytoplasm and to chromatin; homolog of human RagC and RagD microautophagy|positive regulation of transcription from RNA polymerase II promoter GTP binding nuclear chromatin|fungal-type vacuole membrane|integral to membrane|EGO complex|nucleus|late endosome membrane|cytoplasm
YLR202C_d YLR202C YLR202C hom Dubious 0.739312979780504 0.22985848471323 no 1107 0.227236321502602 788 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YLR201C; ORF contains a putative intron Unknown Unknown Unknown
YFL007W YFL007W BLM10 hom Verified 0.738831284504998 0.230004726212501 no 1108 0.232874433756679 811 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS NUCLEUS Proteasome activator; binds the core proteasome and stimulates proteasome-mediated protein degradation by inducing gate opening; required for resistance to bleomycin, may be involved in protecting against oxidative damage; similar to mammalian PA200 proteasome assembly|regulation of proteasomal protein catabolic process proteasome binding|peptidase activator activity proteasome core complex|proteasome complex|integral to membrane|nucleus
YPR098C YPR098C YPR098C hom Verified 0.73825606423689 0.230179429864874 no 1109 0.251066362175894 854 NA FT MITOCHONDRION Protein of unknown function, localized to the mitochondrial outer membrane biological_process molecular_function mitochondrial outer membrane|mitochondrion
YGR151C_d YGR151C YGR151C hom Dubious 0.738138611960147 0.230215111135088 no 1110 0.228604498122698 790 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF RSR1/BUD1/YGR152C; relative distribution to the nucleus increases upon DNA replication stress Unknown Unknown Unknown
YLR057W YLR057W MNL2 hom Verified 0.737425036967617 0.230431957256358 no 1111 0.245060068484775 814 NA FT PROTEOLYSIS ENDOPLASMIC RETICULUM Putative mannosidase involved in ER-associated protein degradation; localizes to the endoplasmic reticulum; sequence similarity with seven-hairpin glycosidase (GH47) family members, such as Mns1p and Mnl1p, that hydrolyze 1,2-linked alpha-D-mannose residues; non-essential gene ER-associated protein catabolic process molecular_function endoplasmic reticulum
YBL012C_d YBL012C YBL012C hom Dubious 0.73730845766566 0.230467395031707 no 1112 0.230128402395711 793 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YPR166C YPR166C MRP2 hom Verified 0.737056050158034 0.230544132301208 no 1113 0.255420678133209 862 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the small subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial small ribosomal subunit
YEL017W YEL017W GTT3 hom Verified 0.735889741961321 0.230898900256674 no 1114 0.213248782202356 741 NA FT ENDOMEMBRANE SYSTEM|NUCLEUS Protein of unknown function with a possible role in glutathione metabolism, as suggested by computational analysis of large-scale protein-protein interaction data; GFP-fusion protein localizes to the nuclear periphery biological_process molecular_function cellular_component
YBL086C_p YBL086C YBL086C hom Uncharacterized 0.735877730403792 0.230902555520759 no 1115 0.211083571955953 708 NA Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery biological_process molecular_function cellular_component
YPL058C YPL058C PDR12 hom Verified 0.735046914515557 0.231155461363291 no 1116 0.23250214761985 782 NA FT KETONE METABOLISM|NUCLEOTIDE METABOLISM PLASMA MEMBRANE Plasma membrane ATP-binding cassette (ABC) transporter, weak-acid-inducible multidrug transporter required for weak organic acid resistance; induced by sorbate and benzoate and regulated by War1p; mutants exhibit sorbate hypersensitivity propionate metabolic process|transport|organic acid transport xenobiotic-transporting ATPase activity|organic acid transmembrane transporter activity integral to membrane|plasma membrane
YDR273W YDR273W DON1 hom Verified 0.73458171325785 0.231297139175124 no 1117 0.200041518206849 706 NA FT CELL CYCLE|CELL WALL ORG/BIOGENESIS|CELL DIVISION Meiosis-specific component of the spindle pole body, part of the leading edge protein (LEP) coat, forms a ring-like structure at the leading edge of the prospore membrane during meiosis II meiosis|ascospore wall assembly molecular_function prospore membrane
YGL260W_p YGL260W YGL260W hom Uncharacterized 0.734194799310132 0.23141501134362 no 1118 0.215739991588177 731 NA Putative protein of unknown function; transcription is significantly increased in a NAP1 deletion background; deletion mutant has increased accumulation of nickel and selenium biological_process molecular_function cellular_component
YGR055W YGR055W MUP1 hom Verified 0.734095984853085 0.231445120239091 no 1119 0.234038741831947 781 NA FT PLASMA MEMBRANE High affinity methionine permease, integral membrane protein with 13 putative membrane-spanning regions; also involved in cysteine uptake cysteine transport|sulfur amino acid transport|methionine transport L-methionine secondary active transmembrane transporter activity integral to membrane|integral to plasma membrane
YGL257C YGL257C MNT2 hom Verified 0.734015551725728 0.231469629931659 no 1120 0.232498209984495 778 NA FT CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Mannosyltransferase involved in adding the 4th and 5th mannose residues of O-linked glycans protein O-linked glycosylation alpha-1,3-mannosyltransferase activity cellular_component
YJL092W YJL092W SRS2 hom Verified 0.732196545929342 0.23202430613645 no 1121 0.238494232279411 835 NA FT RESPONSE TO DNA DAMAGE NUCLEUS DNA helicase and DNA-dependent ATPase involved in DNA repair and checkpoint recovery, needed for proper timing of commitment to meiotic recombination and transition from Meiosis I to II; blocks trinucleotide repeat expansion; affects genome stability DNA repair|double-strand break repair via nonhomologous end joining|DNA duplex unwinding DNA helicase activity nucleus
YBR115C YBR115C LYS2 hom Verified 0.732132845409709 0.232043743975171 no 1122 0.216029310898335 709 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS Alpha aminoadipate reductase, catalyzes the reduction of alpha-aminoadipate to alpha-aminoadipate 6-semialdehyde, which is the fifth step in biosynthesis of lysine; activation requires posttranslational phosphopantetheinylation by Lys5p lysine biosynthetic process via aminoadipic acid L-aminoadipate-semialdehyde dehydrogenase activity cytoplasm
YMR261C YMR261C TPS3 hom Verified 0.731031548429858 0.232379941555792 no 1123 0.224476698580333 761 NA FT CARBOHYDRATE METABOLISM Regulatory subunit of trehalose-6-phosphate synthase/phosphatase; involved in synthesis of storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway; TPS3 has a paralog, TSL1, that arose from the whole genome duplication trehalose biosynthetic process|response to stress enzyme regulator activity|alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity|trehalose-phosphatase activity alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)
YFL003C YFL003C MSH4 hom Verified 0.73050620559984 0.232540410582617 no 1124 0.195129656349912 624 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME Protein involved in meiotic recombination, required for normal levels of crossing over, colocalizes with Zip2p to discrete foci on meiotic chromosomes, has homology to bacterial MutS protein reciprocal meiotic recombination DNA binding nuclear chromosome
YKL220C YKL220C FRE2 hom Verified 0.730460536628622 0.232554363346124 no 1125 0.203306775263259 666 NA FT ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|GEN. OF PRECURSOR METABOLITES AND ENERGY PLASMA MEMBRANE Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low iron levels but not by low copper levels iron ion transport|copper ion import ferric-chelate reductase activity integral to membrane|plasma membrane
YBR106W YBR106W PHO88 hom Verified 0.730030851305094 0.232685663402604 no 1126 0.300424698445948 1056 NA FF|FT ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION Probable membrane protein, involved in phosphate transport; pho88 pho86 double null mutant exhibits enhanced synthesis of repressible acid phosphatase at high inorganic phosphate concentrations phosphate ion transport molecular_function mitochondrion|membrane
YBR099C_d YBR099C YBR099C hom Dubious 0.72975596800892 0.232769681809171 no 1127 0.219478428561211 739 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene MMS4 Unknown Unknown Unknown
YMR081C YMR081C ISF1 hom Verified 0.72853541177847 0.233142949816373 no 1128 0.217927318162506 780 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY Serine-rich, hydrophilic protein with similarity to Mbr1p; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; expression is under glucose control; cotranscribed with NAM7 in a cyp1 mutant aerobic respiration molecular_function cellular_component
YDR490C YDR490C PKH1 hom Verified 0.728206992783134 0.233243442947533 no 1129 0.217737624776599 764 NA FT VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|RNA PROCESSING|SIGNALING|CELL WALL ORG/BIOGENESIS|PROTEIN PHOSPHORYLATION Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; redundant with Pkh2p regulation of nuclear-transcribed mRNA poly(A) tail shortening|endocytosis|protein phosphorylation|MAPK cascade involved in cell wall biogenesis|cytoplasmic mRNA processing body assembly protein kinase activity cytosol|cell cortex|eisosome
YDL229W YDL229W SSB1 hom Verified 0.728048333088093 0.233291999936837 no 1130 0.206107776946428 671 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RESPONSE TO NUTRIENT LEVELS Cytoplasmic ATPase that is a ribosome-associated molecular chaperone; functions with J-protein partner Zuo1p; may be involved in folding of newly-made polypeptide chains; member of the HSP70 family; interacts with phosphatase subunit Reg1p; SSB1 has a paralog, SSB2, that arose from the whole genome duplication cytoplasmic translation|cellular response to glucose starvation|translational termination|ribosomal subunit export from nucleus|regulation of translational fidelity|rRNA processing|'de novo' cotranslational protein folding unfolded protein binding|ATPase activity|calmodulin binding plasma membrane|polysome|cytoplasm
YDR029W_d YDR029W YDR029W hom Dubious 0.727945925013891 0.233323344383635 no 1131 0.213327292359515 706 NA Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YAR014C YAR014C BUD14 hom Verified 0.727625924351397 0.233421303318102 no 1132 0.227921192006652 852 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH Protein involved in bud-site selection; Bud14p-Glc7p complex is a cortical regulator of dynein; inhibitor of the actin assembly factor Bnr1p (formin); diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; relative distribution to the nucleus increases upon DNA replication stress regulation of cell shape during vegetative growth phase|regulation of protein localization|regulation of transcription, DNA-dependent|cytoskeleton organization|negative regulation of actin filament polymerization protein phosphatase type 1 regulator activity incipient cellular bud site|cellular bud neck|cellular bud tip
YLR213C YLR213C CRR1 hom Verified 0.72671789829272 0.233699393382387 no 1133 0.220698968374823 753 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM Putative glycoside hydrolase of the spore wall envelope; required for normal spore wall assembly, possibly for cross-linking between the glucan and chitosan layers; expressed during sporulation ascospore wall assembly hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds ascospore wall
YDR428C YDR428C BNA7 hom Verified 0.72660649825226 0.233733523157782 no 1134 0.212644319223505 696 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM Formylkynurenine formamidase, involved in the de novo biosynthesis of NAD from tryptophan via kynurenine NAD biosynthetic process arylformamidase activity cellular_component
YDL234C YDL234C GYP7 hom Verified 0.724052128239444 0.234516866372982 no 1135 0.201397666978584 681 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING|NUCLEOTIDE METABOLISM GTPase-activating protein for yeast Rab family members including: Ypt7p (most effective), Ypt1p, Ypt31p, and Ypt32p (in vitro); involved in vesicle mediated protein trafficking regulation of vacuole fusion, non-autophagic|vesicle-mediated transport Rab GTPase activator activity cytoplasm
YDL086W_p YDL086W YDL086W hom Uncharacterized 0.723387311197093 0.234720982324096 no 1136 0.190074661521357 654 NA FT MITOCHONDRION Putative carboxymethylenebutenolidase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL086W is not an essential gene biological_process carboxymethylenebutenolidase activity mitochondrion|cytoplasm
YIR028W YIR028W DAL4 hom Verified 0.723183651867916 0.234783530630769 no 1137 0.228902895163855 759 NA Allantoin permease; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation allantoin catabolic process|allantoin transport allantoin uptake transmembrane transporter activity integral to membrane|membrane
YLR369W YLR369W SSQ1 hom Verified 0.723044357273743 0.234826316402348 no 1138 0.231100610195294 767 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS|COFACTOR METABOLISM MITOCHONDRION Mitochondrial hsp70-type molecular chaperone, required for assembly of iron/sulfur clusters into proteins at a step after cluster synthesis, and for maturation of Yfh1p, which is a homolog of human frataxin implicated in Friedreich's ataxia iron-sulfur cluster assembly|intracellular sequestering of iron ion|protein maturation unfolded protein binding mitochondrion|mitochondrial matrix
YPL273W YPL273W SAM4 hom Verified 0.722249811695227 0.235070451658877 no 1139 0.22149743411037 795 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM NUCLEUS S-adenosylmethionine-homocysteine methyltransferase, functions along with Mht1p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio homocysteine metabolic process|L-methionine biosynthetic process from S-adenosylmethionine|S-adenosylhomocysteine metabolic process homocysteine S-methyltransferase activity nucleus|cytoplasm
YLR433C YLR433C CNA1 hom Verified 0.722132681804077 0.235106453312374 no 1140 0.208045228327509 749 NA FT SIGNALING|ION HOMEOSTASIS|CELL WALL ORG/BIOGENESIS|ION HOMEOSTASIS Calcineurin A; one isoform (the other is CMP2) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1 adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion|fungal-type cell wall organization|cellular ion homeostasis calcium-dependent protein serine/threonine phosphatase activity calcineurin complex|cytoplasm
YJL079C YJL079C PRY1 hom Verified 0.721361212648055 0.235343652162347 no 1141 0.195072055383689 692 NA FT ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM Sterol binding protein involved in the export of acetylated sterols; secreted glycoprotein and member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis related 1 proteins); sterol export function is redundant with that of PRY2; may be involved in detoxification of hydrophobic compounds; PRY1 has a paralog, PRY2, that arose from the whole genome duplication biological_process molecular_function nuclear envelope|extracellular region|endoplasmic reticulum|fungal-type vacuole
YLL002W YLL002W RTT109 hom Verified 0.721051382269932 0.235438950958988 no 1142 0.24147628756039 832 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE NUCLEUS Histone acetyltransferase critical for cell survival in the presence of DNA damage during S phase; acetylates H3-K56 and H3-K9; involved in non-homologous end joining and in regulation of Ty1 transposition; interacts physically with Vps75p negative regulation of transposition, RNA-mediated|histone acetylation|double-strand break repair via nonhomologous end joining|response to DNA damage stimulus|regulation of transcription from RNA polymerase II promoter in response to stress H3 histone acetyltransferase activity nucleus
YGR148C YGR148C RPL24B hom Verified 0.720213273864589 0.235696846192475 no 1143 0.239851608127295 797 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L24B; not essential for translation but may be required for normal translation rate; homologous to mammalian ribosomal protein L24, no bacterial homolog; RPL24B has a paralog, RPL24A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome|RNA binding cytosolic large ribosomal subunit
YBL046W YBL046W PSY4 hom Verified 0.719490490564556 0.235919379668436 no 1144 0.23074319456533 814 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE NUCLEUS Regulatory subunit of protein phosphatase PP4; presence of Psy4p in the PP4 complex (along with catalytic subunit Pph3p and Psy2p) is required for dephosphorylation of the histone variant H2AX, but not for dephosphorylation of Rad53p, during recovery from the DNA damage checkpoint; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; required for cisplatin resistance; homolog of mammalian R2 Unknown|protein dephosphorylation protein phosphatase regulator activity nucleus|cytoplasm
YGL227W YGL227W VID30 hom Verified 0.719382153357703 0.235952744947306 no 1145 0.237067675574332 791 NA FT KETONE METABOLISM|CARBOHYDRATE METABOLISM|PROTEOLYSIS NUCLEUS Central component of GID Complex, involved in FBPase degradation; interacts strongly with Gid8p to serve as a scaffold for other GID Complex subunits; contains SPRY domain and 3 domains that are also found in Gid8p - LisH, CTLH, and CRA; required for association of Vid vesicles and actin patches in vacuole import and degradation pathway; shifts the balance of nitrogen metabolism toward glutamate production; localizes to the nucleus and the cytoplasm regulation of nitrogen utilization|negative regulation of gluconeogenesis|proteasomal ubiquitin-dependent protein catabolic process|vacuolar protein catabolic process molecular_function nucleus|GID complex|cytoplasm
YPL001W YPL001W HAT1 hom Verified 0.718589790220538 0.236196852967636 no 1146 0.252676247216786 886 NA FT CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING NUCLEUS HISTONE ACETYLTRANSFERASE Catalytic subunit of the Hat1p-Hat2p histone acetyltransferase complex that uses the cofactor acetyl coenzyme A, to acetylate free nuclear and cytoplasmic histone H4; involved in telomeric silencing and DNA double-strand break repair histone acetylation|chromatin silencing at telomere histone acetyltransferase activity|histone binding histone acetyltransferase complex|nucleus|cytoplasm
YOR086C YOR086C TCB1 hom Verified 0.717115997545598 0.236651262771435 no 1147 0.209616221107172 707 NA FT ENDOPLASMIC RETICULUM|MITOCHONDRION|PLASMA MEMBRANE Lipid-binding ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; contains three calcium and lipid binding domains; non-tagged protein also localizes to mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact biological_process lipid binding mitochondrion|plasma membrane|cortical endoplasmic reticulum
YPR042C YPR042C PUF2 hom Verified 0.717079063084793 0.236662656830047 no 1148 0.254490910909013 885 NA Member of the PUF protein family, which is defined by the presence of Pumilio homology domains that confer RNA binding activity; preferentially binds mRNAs encoding membrane-associated proteins nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay mRNA binding cytoplasm
YLL012W YLL012W YEH1 hom Verified 0.716953651591462 0.236701347772035 no 1149 0.207398449399002 672 NA FT LIPID METABOLISM Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes sterol metabolic process sterol esterase activity integral to membrane|lipid particle
YNL031C YNL031C HHT2 hom Verified 0.716381833100721 0.23687780468914 no 1150 0.218762248839186 751 NA FT CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME Histone H3, core histone protein required for chromatin assembly, part of heterochromatin-mediated telomeric and HM silencing; one of two identical histone H3 proteins (see HHT1); regulated by acetylation, methylation, and phosphorylation chromatin assembly or disassembly|global genome nucleotide-excision repair|rRNA transcription|sexual sporulation resulting in formation of a cellular spore|mitotic cell cycle spindle assembly checkpoint DNA binding nuclear nucleosome
YPL130W YPL130W SPO19 hom Verified 0.716247491097159 0.236919271647777 no 1151 0.208091605312717 686 NA FT CELL CYCLE|MEMBRANE ORGANIZATION Meiosis-specific prospore protein; required to produce bending force necessary for proper assembly of the prospore membrane during sporulation; identified as a weak high-copy suppressor of the spo1-1 ts mutation meiosis|spore membrane bending pathway molecular_function fungal-type cell wall|prospore membrane
YGL041C-B_p YGL041C-B YGL041C-B hom Uncharacterized 0.716239387664326 0.236921773038617 no 1152 0.22090708944571 728 NA Putative protein of unknown function; identified by fungal homology and RT-PCR biological_process molecular_function cellular_component
YDR174W YDR174W HMO1 hom Verified 0.715713314025934 0.237084194016504 no 1153 0.236351355879266 848 NA FT TRANSCRIPTION FROM RNA POL II|RIBOSOME BIOGENESIS|CHROMATIN ORGANIZATION NUCLEUS|CHROMOSOME Chromatin associated high mobility group (HMG) family member involved in genome maintenance; rDNA-binding component of the Pol I transcription system; associates with a 5'-3' DNA helicase and Fpr1p, a prolyl isomerase regulation of transcription from RNA polymerase I promoter|regulation of transcription by chromatin organization|regulation of ribosomal protein gene transcription from RNA polymerase II promoter double-stranded DNA binding|four-way junction DNA binding|DNA binding, bending nuclear chromatin|nucleolus|cytoplasm
YKL003C YKL003C MRP17 hom Verified 0.715207117456424 0.237240535853476 no 1154 0.245908125343189 842 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the small subunit; MRP17 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial small ribosomal subunit
YLR420W YLR420W URA4 hom Verified 0.715017871620187 0.237299000101167 no 1155 0.248158180438953 835 NA FT NUCLEOTIDE METABOLISM NUCLEUS Dihydroorotase, catalyzes the third enzymatic step in the de novo biosynthesis of pyrimidines, converting carbamoyl-L-aspartate into dihydroorotate 'de novo' pyrimidine nucleobase biosynthetic process|pyrimidine nucleotide biosynthetic process dihydroorotase activity nucleus|cytoplasm
YPL192C YPL192C PRM3 hom Verified 0.714948883160009 0.237320314867733 no 1156 0.218898742005244 782 NA FT MEMBRANE ORGANIZATION ENDOMEMBRANE SYSTEM|NUCLEUS|CYTOSKELETON Pheromone-regulated protein required for nuclear envelope fusion during karyogamy; localizes to the outer face of the nuclear membrane; interacts with Kar5p at the spindle pole body karyogamy involved in conjugation with cellular fusion|nuclear membrane fusion involved in karyogamy molecular_function nuclear envelope|spindle pole body|extrinsic to nuclear outer membrane
YMR097C YMR097C MTG1 hom Verified 0.71427333961321 0.237529087245857 no 1157 0.255687805875093 889 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Putative GTPase peripheral to the mitochondrial inner membrane, essential for respiratory competence, likely functions in assembly of the large ribosomal subunit, has homologs in plants and animals mitochondrial translation GTPase activity mitochondrion|mitochondrial inner membrane
YDL011C_d YDL011C YDL011C hom Dubious 0.713006267704856 0.237920939349829 no 1158 0.223713448685249 752 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the uncharacterized ORF YDL010W Unknown Unknown Unknown
YKR014C YKR014C YPT52 hom Verified 0.712523419753004 0.238070357149315 no 1159 0.244569218816375 857 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING|VACUOLAR TRANSPORT ENDOPLASMIC RETICULUM|PLASMA MEMBRANE Rab family GTPase, similar to Ypt51p and Ypt53p and to mammalian rab5; required for vacuolar protein sorting and endocytosis; protein abundance increases in response to DNA replication stress endocytosis|protein targeting to vacuole GTPase activity late endosome
YIL014C-A_p YIL014C-A YIL014C-A hom Uncharacterized 0.712387132764395 0.238112540604157 no 1160 0.250309600689087 877 NA Putative protein of unknown function biological_process molecular_function cellular_component
YPR129W YPR129W SCD6 hom Verified 0.711799397228469 0.23829450301439 no 1161 0.263248990637023 897 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION Repressor of translation initiation; binds eIF4G through its RGG domain and inhibits recruitment of the preinitiation complex; also contains an Lsm domain; may have a role in RNA processing; overproduction suppresses null mutation in clathrin heavy chain gene CHC1; forms cytoplasmic foci upon DNA replication stress stress granule assembly|negative regulation of translational initiation|cytoplasmic mRNA processing body assembly mRNA binding|RNA binding|eukaryotic initiation factor 4G binding cytoplasmic mRNA processing body|cytoplasmic stress granule|cytoplasm
YGL261C_p YGL261C PAU11 hom Uncharacterized 0.711511755587271 0.238383584368144 no 1162 0.237806542527863 795 NA Putative protein of unknown function and member of the seripauperin multigene family encoded mainly in subtelomeric regions; mRNA expression appears to be regulated by SUT1 and UPC2 biological_process molecular_function cellular_component
YLR381W YLR381W CTF3 hom Verified 0.711349698950051 0.238433780627696 no 1163 0.211838114766147 730 NA FT CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME KINETOCHORE Outer kinetochore protein that forms a complex with Mcm16p and Mcm22p; may bind the kinetochore to spindle microtubules; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-I and fission yeast mis6 chromosome segregation|DNA replication initiation|establishment of mitotic sister chromatid cohesion molecular_function condensed nuclear chromosome kinetochore
YGL028C YGL028C SCW11 hom Verified 0.710964416015557 0.23855314338569 no 1164 0.250184750622841 870 NA FT CELL WALL ORG/BIOGENESIS|CELL DIVISION|CARBOHYDRATE METABOLISM Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on its regulation by Ste12p cytokinesis, completion of separation glucan endo-1,3-beta-D-glucosidase activity fungal-type cell wall
YIR037W YIR037W HYR1 hom Verified 0.710482930648352 0.238702356149562 no 1165 0.245820784828901 860 NA FT OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS Thiol peroxidase that functions as a hydroperoxide receptor to sense intracellular hydroperoxide levels and transduce a redox signal to the Yap1p transcription factor cellular response to oxidative stress phospholipid-hydroperoxide glutathione peroxidase activity|glutathione peroxidase activity intracellular
YFL055W YFL055W AGP3 hom Verified 0.710100918305815 0.23882077845239 no 1166 0.228644090860463 783 NA FT PLASMA MEMBRANE Low-affinity amino acid permease, may act to supply the cell with amino acids as nitrogen source in nitrogen-poor conditions; transcription is induced under conditions of sulfur limitation; plays a role in regulating Ty1 transposition amino acid transport|transmembrane transport amino acid transmembrane transporter activity integral to membrane|plasma membrane
YJL128C YJL128C PBS2 hom Verified 0.709632087969647 0.238966157896819 no 1167 0.274218441979142 967 NA FF|FT PROTEIN LOCALIZATION|SIGNALING|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION SITE OF POLARIZED GROWTH MAP kinase kinase of the HOG signaling pathway; activated under severe osmotic stress; mitophagy-specific regulator; plays a role in regulating Ty1 transposition activation of MAPK activity involved in osmosensory signaling pathway|actin filament organization|MAPK import into nucleus involved in osmosensory signaling pathway|protein phosphorylation|hyperosmotic response|osmosensory signaling pathway|cellular response to heat MAP-kinase scaffold activity|MAP kinase kinase activity|protein kinase activity cellular bud neck|cytoplasm|cellular bud tip
YPL207W YPL207W TYW1 hom Verified 0.708847165521469 0.239209662525363 no 1168 0.236045917591236 828 NA FT RNA PROCESSING|OXIDATION-REDUCTION PROCESS ENDOPLASMIC RETICULUM Iron-sulfer protein required for synthesis of Wybutosine modified tRNA; Wybutosine is a modified guanosine found at the 3'-position adjacent to the anticodon of phenylalanine tRNA which supports reading frame maintenance by stabilizing codon-anticodon interactions; induction by Yap5p in response to iron provides protection from high iron toxicity; overexpression results in increased cellular iron wybutosine biosynthetic process molecular_function endoplasmic reticulum
YDR248C_p YDR248C YDR248C hom Uncharacterized 0.708629285667218 0.239277278908864 no 1169 0.222256972664444 753 NA FT KETONE METABOLISM|CARBOHYDRATE METABOLISM Putative gluconokinase; sequence similarity to bacterial and human gluconokinase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; upregulated by deletion of the RNAP-II associated factor, PAF1 biological_process molecular_function cytoplasm
YLR445W YLR445W GMC2 hom Verified 0.708295541709472 0.239380872562965 no 1170 0.241396138952803 823 NA FT CELL CYCLE Protein involved in meiotic progression; mutants are delayed in meiotic nuclear division and are defective in synaptonemal complex assembly; transcription is regulated by Ume6p and induced in response to alpha factor meiosis|synaptonemal complex organization molecular_function cellular_component
YJL052W YJL052W TDH1 hom Verified 0.707929043202619 0.23949466139748 no 1171 0.270113945278822 923 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Glyceraldehyde-3-phosphate dehydrogenase, isozyme 1; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; protein abundance increases in response to DNA replication stress gluconeogenesis|glycolysis glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity mitochondrion|fungal-type cell wall|lipid particle|plasma membrane|cytoplasm
YJR142W_p YJR142W YJR142W hom Uncharacterized 0.707460803857822 0.239640081235818 no 1172 0.230631644667133 855 NA Putative protein of unknown function; GST fusion protein is a Dbf2p-Mob1p phosphorylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition; nudix hydrolase family member biological_process molecular_function cellular_component
YLL040C YLL040C VPS13 hom Verified 0.707340588682067 0.239677423914094 no 1173 0.232286387730201 779 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT MITOCHONDRION|GOLGI APPARATUS Protein of unknown function; heterooligomeric or homooligomeric complex; peripherally associated with membranes; involved in sporulation, vacuolar protein sorting, prospore membrane formation and protein-Golgi retention; homologous to human CHAC and COH1 which are involved in chorea acanthocytosis and Cohen syndrome, respectively protein retention in Golgi apparatus|late endosome to vacuole transport|protein targeting to vacuole|ascospore-type prospore membrane assembly molecular_function endosome|mitochondrion|prospore membrane|extrinsic to membrane
YGR194C YGR194C XKS1 hom Verified 0.707288631944459 0.239693564321282 no 1174 0.210679346890162 728 NA FT CARBOHYDRATE METABOLISM Xylulokinase, converts D-xylulose and ATP to xylulose 5-phosphate and ADP; rate limiting step in fermentation of xylulose; required for xylose fermentation by recombinant S. cerevisiae strains xylulose catabolic process xylulokinase activity cytoplasm
YDR111C_p YDR111C ALT2 hom Uncharacterized 0.706892215712841 0.239816730905089 no 1175 0.22693954040876 764 NA FT KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS Catalytically inactive paralog of ALT1, an alanine transaminase; expression is repressed in the presence of alanine and repression is mediated by Nrg1p biological_process transaminase activity nucleus|cytoplasm
YFR043C YFR043C IRC6 hom Verified 0.704821973105772 0.240460516239708 no 1176 0.242134878373786 825 NA Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci biological_process molecular_function cellular_component
YGR067C_p YGR067C YGR067C hom Uncharacterized 0.704685715296224 0.240502921449436 no 1177 0.222745047990068 756 NA FT NUCLEUS Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p biological_process sequence-specific DNA binding cellular_component
YOR209C YOR209C NPT1 hom Verified 0.704422189080355 0.240584945801828 no 1178 0.306589205400373 1074 NA FF|FT NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|GENE SILENCING|RESPONSE TO OXIDATIVE STRESS NUCLEUS Nicotinate phosphoribosyltransferase, acts in the salvage pathway of NAD+ biosynthesis; required for silencing at rDNA and telomeres and has a role in silencing at mating-type loci; localized to the nucleus chromatin silencing at rDNA|replicative cell aging|nicotinate nucleotide salvage|chromatin silencing at telomere nicotinate phosphoribosyltransferase activity nucleus
YOR296W_p YOR296W YOR296W hom Uncharacterized 0.704227505306916 0.240645552249726 no 1179 0.201254138216513 690 NA Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; expressed during copper starvation; YOR296W is not an essential gene biological_process molecular_function cytoplasm
YOR330C YOR330C MIP1 hom Verified 0.703847427526853 0.240763897121363 no 1180 0.211959635133482 716 NA FT MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit mitochondrial DNA replication 3'-5' exonuclease activity|DNA-directed DNA polymerase activity mitochondrion
YKR088C YKR088C TVP38 hom Verified 0.703810416682219 0.24077542288515 no 1181 0.24006178097071 853 NA FT VESICLE-MEDIATED TRANSPORT|CELL CYCLE|CYTOSKELETON ORGANIZATION ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; required for asymmetric localization of Kar9p during mitosis; GFP-fusion protein localizes to the cytoplasm in a punctate pattern vesicle-mediated transport|mitotic spindle elongation molecular_function integral to membrane|integral to Golgi membrane|cytoplasm
YKL133C_p YKL133C YKL133C hom Uncharacterized 0.703374018457753 0.240911346849515 no 1182 0.259332219540737 880 NA Putative protein of unknown function; has similarity to Mgr3p, but unlike MGR3, is not required for growth of cells lacking the mitochondrial genome (null mutation does not confer a petite-negative phenotype) biological_process molecular_function cellular_component
YDR453C YDR453C TSA2 hom Verified 0.702270839508748 0.241255137535888 no 1183 0.223657481378478 735 NA FT OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS Stress inducible cytoplasmic thioredoxin peroxidase; cooperates with Tsa1p in the removal of reactive oxygen, nitrogen and sulfur species using thioredoxin as hydrogen donor; deletion enhances the mutator phenotype of tsa1 mutants; protein abundance increases in response to DNA replication stress cellular response to oxidative stress|cell redox homeostasis peroxiredoxin activity|thioredoxin peroxidase activity cytoplasm
YGR226C_d YGR226C YGR226C hom Dubious 0.701564347760775 0.24147544603307 no 1184 0.246365616945811 836 NA Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; overlaps significantly with a verified ORF, AMA1/YGR225W Unknown Unknown Unknown
YIR042C_p YIR042C YIR042C hom Uncharacterized 0.701471116279591 0.241504526983867 no 1185 0.228181064779311 744 NA Putative protein of unknown function; YIR042C is a non-essential gene biological_process molecular_function cellular_component
YHR124W YHR124W NDT80 hom Verified 0.700486204851777 0.241811858684094 no 1186 0.231454212829667 839 NA FT CELL CYCLE|CELL DIVISION NUCLEUS|CHROMOSOME Meiosis-specific transcription factor required for exit from pachytene and for full meiotic recombination; activates middle sporulation genes; competes with Sum1p for binding to promoters containing middle sporulation elements (MSE) meiosis|transcription, DNA-dependent sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity nuclear chromosome
YAL047C YAL047C SPC72 hom Verified 0.699277249699357 0.242189390926276 no 1187 0.249003845077104 833 NA FT CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION NUCLEUS|CYTOSKELETON Component of the cytoplasmic Tub4p (gamma-tubulin) complex, binds spindle pole bodies and links them to microtubules; has roles in astral microtubule formation and stabilization microtubule nucleation|nuclear migration along microtubule|mitotic cell cycle spindle orientation checkpoint|mitotic spindle elongation|mitotic sister chromatid segregation structural constituent of cytoskeleton outer plaque of spindle pole body
YDL213C YDL213C NOP6 hom Verified 0.699242632668496 0.242200205828477 no 1188 0.247836684304889 848 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS rRNA-binding protein required for 40S ribosomal subunit biogenesis; contains an RNA recognition motif (RRM); hydrophilin essential to overcome the stress of the desiccation-rehydration process; NOP6 may be a fungal-specific gene as no homologs have been yet identified in higher eukaryotes ribosomal small subunit biogenesis RNA binding|rRNA binding nucleolus|90S preribosome
YLR135W YLR135W SLX4 hom Verified 0.698975496844137 0.242283672045011 no 1189 0.228107066793484 757 NA FT RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME Endonuclease involved in processing DNA; acts during recombination and repair; cleaves branched structures in a complex with Slx1p; involved interstrand cross-link repair and in Rad1p/Rad10p-dependent removal of 3'-nonhomologous tails during DSBR via single-strand annealing; relative distribution to nuclear foci increases upon DNA replication stress double-strand break repair via single-strand annealing, removal of nonhomologous ends|DNA replication|response to DNA damage stimulus|DNA-dependent DNA replication 5'-flap endonuclease activity Slx1-Slx4 complex|nucleus
YMR187C_p YMR187C YMR187C hom Uncharacterized 0.698700677777481 0.24236955514514 no 1190 0.239824147960367 796 NA Putative protein of unknown function; YMR187C is not an essential gene biological_process molecular_function integral to membrane
YKL005C YKL005C BYE1 hom Verified 0.698094159948299 0.242559155053483 no 1191 0.232148671636479 755 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Negative regulator of transcription elongation, contains a TFIIS-like domain and a PHD finger, multicopy suppressor of temperature-sensitive ess1 mutations, probably binds RNA polymerase II large subunit negative regulation of transcription from RNA polymerase II promoter methylated histone residue binding nucleus
YOR084W YOR084W LPX1 hom Verified 0.69793177156675 0.24260993194192 no 1192 0.206505790726264 664 NA FT PEROXISOME ORGANIZATION Oleic acid-inducible, peroxisomal matrix localized lipase; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance; peroxisomal import is dependent on the PTS1 receptor, Pex5p and on self-interaction peroxisome organization lipase activity peroxisomal matrix
YJR135C YJR135C MCM22 hom Verified 0.697625558331507 0.242705696785332 no 1193 0.227823726080844 771 NA FT CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME KINETOCHORE Outer kinetochore protein and component of the Ctf3 subcomplex; binds to centromeric DNA in a Ctf19p-dependent manner; involved in chromosome segregation and minichromosome maintenance; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-K and fission yeast sim4 chromosome segregation|establishment of mitotic sister chromatid cohesion molecular_function condensed nuclear chromosome kinetochore
YML052W YML052W SUR7 hom Verified 0.696488958288423 0.243061334904697 no 1194 0.213205624742003 750 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION MITOCHONDRION|PLASMA MEMBRANE Plasma membrane protein that localizes to furrow-like invaginations (MCC patches); component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants endocytosis|ascospore formation molecular_function cell cortex|eisosome|mitochondrion|membrane raft|integral to membrane|plasma membrane|actin cortical patch
YGL251C YGL251C HFM1 hom Verified 0.696280186928126 0.243126689346856 no 1195 0.263732122438561 903 NA FT CELL CYCLE NUCLEUS Meiosis specific DNA helicase involved in the conversion of double-stranded breaks to later recombination intermediates and in crossover control; catalyzes the unwinding of Holliday junctions; has ssDNA and dsDNA stimulated ATPase activity meiosis|synapsis|DNA unwinding involved in replication|reciprocal meiotic recombination DNA helicase activity nucleus
YFR049W YFR049W YMR31 hom Verified 0.695470716797701 0.243380178239001 no 1196 0.267246340202861 916 NA FT TRANSLATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the small subunit, has similarity to human mitochondrial ribosomal protein MRP-S36 cytoplasmic translation structural constituent of ribosome mitochondrion|mitochondrial small ribosomal subunit
YPR049C YPR049C ATG11 hom Verified 0.69535730917499 0.243415703703547 no 1197 0.256840651901447 881 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|PEROXISOME ORGANIZATION Adapter protein for pexophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; directs receptor-bound cargo to the phagophore assembly site (PAS) for packaging into vesicles; required for recruiting other proteins to the (PAS) piecemeal microautophagy of nucleus|mitochondrion degradation|peroxisome degradation|protein localization to pre-autophagosomal structure|CVT pathway protein complex scaffold pre-autophagosomal structure|extrinsic to membrane
YPR014C_d YPR014C YPR014C hom Dubious 0.69501023510392 0.243524443674451 no 1198 0.228795590908697 822 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPR014C is not an essential gene Unknown Unknown Unknown
YDR317W YDR317W HIM1 hom Verified 0.694451805062996 0.243699457541867 no 1199 0.222338737415313 754 NA FT RESPONSE TO DNA DAMAGE Protein of unknown function involved in DNA repair DNA repair molecular_function cellular_component
YPR189W YPR189W SKI3 hom Verified 0.693789163800428 0.243907219625327 no 1200 0.221576270121169 772 NA FT NUCLEUS Ski complex component and TPR protein, mediates 3'-5' RNA degradation by the cytoplasmic exosome; null mutants have superkiller phenotype of increased viral dsRNAs and are synthetic lethal with mutations in 5'-3' mRNA decay nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'|nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay|nuclear-transcribed mRNA catabolic process, non-stop decay molecular_function Ski complex
YML072C YML072C TCB3 hom Verified 0.693146871390743 0.244108692786824 no 1201 0.251035139090172 878 NA FT ENDOPLASMIC RETICULUM|MITOCHONDRION|PLASMA MEMBRANE Cortical ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; localized to the bud via specific mRNA transport; non-tagged protein detected in a phosphorylated state in mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact biological_process lipid binding mitochondrion|cortical endoplasmic reticulum|cellular bud
YBR082C YBR082C UBC4 hom Verified 0.692351210981156 0.24435839855807 no 1202 0.220463874205226 743 NA FT PROTEOLYSIS Ubiquitin-conjugating enzyme (E2); mediates degradation of abnormal or excess proteins, including calmodulin and histone H3; interacts with many SCF ubiquitin protein ligases; component of the cellular stress response; UBC4 has a paralog, UBC5, that arose from the whole genome duplication ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|protein monoubiquitination|protein polyubiquitination|protein ubiquitination|response to stress ubiquitin binding|ubiquitin-protein ligase activity proteasome complex
YLL056C_p YLL056C YLL056C hom Uncharacterized 0.690774760288148 0.244853549640721 no 1203 0.203849995381155 710 NA Putative protein of unknown function, transcription is activated by paralogous transcription factors Yrm1p and Yrr1p and genes involved in pleiotropic drug resistance (PDR); expression is induced in cells treated with the mycotoxin patulin biological_process molecular_function cellular_component
YBR019C YBR019C GAL10 hom Verified 0.690467129782407 0.244950236956788 no 1204 0.237155828388322 810 NA FT CARBOHYDRATE METABOLISM UDP-glucose-4-epimerase, catalyzes the interconversion of UDP-galactose and UDP-D-glucose in galactose metabolism; also catalyzes the conversion of alpha-D-glucose or alpha-D-galactose to their beta-anomers galactose catabolic process via UDP-galactose aldose 1-epimerase activity|UDP-glucose 4-epimerase activity cytosol
YHL024W YHL024W RIM4 hom Verified 0.690032190806028 0.245086971978241 no 1205 0.265391840851653 921 NA FT CELL CYCLE Putative RNA-binding protein required for the expression of early and middle sporulation genes meiosis|reciprocal meiotic recombination|sporulation resulting in formation of a cellular spore|premeiotic DNA replication RNA binding cytoplasm
YGL213C YGL213C SKI8 hom Verified 0.689611936421743 0.245219129482851 no 1206 0.232396245234843 773 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE NUCLEUS|CHROMOSOME Ski complex component and WD-repeat protein, mediates 3'-5' RNA degradation by the cytoplasmic exosome; also required for meiotic double-strand break recombination; null mutants have superkiller phenotype nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'|nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay|protein complex assembly|nuclear-transcribed mRNA catabolic process, non-stop decay|protein-DNA complex assembly|reciprocal meiotic recombination molecular_function Ski complex|nuclear chromosome
YGL095C YGL095C VPS45 hom Verified 0.689128292597699 0.245371268489349 no 1207 0.32801015208821 1129 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Protein of the Sec1p/Munc-18 family, essential for vacuolar protein sorting; required for the function of Pep12p and the early endosome/late Golgi SNARE Tlg2p; essential for fusion of Golgi-derived vesicles with the prevacuolar compartment vacuole inheritance|CVT pathway|positive regulation of SNARE complex assembly|Golgi vesicle fusion to target membrane|Golgi to vacuole transport|vacuole organization|vacuolar acidification|protein targeting to vacuole|Golgi to endosome transport unfolded protein binding|SNARE binding cytosol|SNARE complex|Golgi membrane|extrinsic to membrane
YLR332W YLR332W MID2 hom Verified 0.688460023880247 0.245581568077661 no 1208 0.262297895859792 895 NA FT RNA PROCESSING|SIGNALING|CELL WALL ORG/BIOGENESIS|PEROXISOME ORGANIZATION SITE OF POLARIZED GROWTH|PLASMA MEMBRANE O-glycosylated plasma membrane protein that acts as a sensor for cell wall integrity signaling and activates the pathway; interacts with Rom2p, a guanine nucleotide exchange factor for Rho1p, and with cell integrity pathway protein Zeo1p UFP-specific transcription factor mRNA processing involved in endoplasmic reticulum unfolded protein response|fungal-type cell wall organization|peroxisome degradation|cell morphogenesis involved in conjugation|response to acid|response to osmotic stress transmembrane signaling receptor activity integral to plasma membrane|mating projection tip
YML080W YML080W DUS1 hom Verified 0.686921493033196 0.246066100994977 no 1209 0.200341447308161 669 NA FT RNA PROCESSING|OXIDATION-REDUCTION PROCESS NUCLEUS Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus3p, and Dus4p; modifies pre-tRNA(Phe) at U17 tRNA modification tRNA dihydrouridine synthase activity nucleus
YDR371W_p YDR371W CTS2 hom Uncharacterized 0.686887938649246 0.246076674062272 no 1210 0.232387672670526 774 NA FT CARBOHYDRATE METABOLISM Putative chitinase, functionally complements A. gossypii cts2 mutant sporulation defect sporulation resulting in formation of a cellular spore molecular_function cytoplasm
YDR071C YDR071C PAA1 hom Verified 0.686854291096298 0.24608727673205 no 1211 0.255817566225612 894 NA FT CHROMATIN ORGANIZATION Polyamine acetyltransferase; acetylates polyamines (e.g. putrescine, spermidine, spermine) and also aralkylamines (e.g. tryptamine, phenylethylamine); may be involved in transcription and/or DNA replication chromatin organization diamine N-acetyltransferase activity|aralkylamine N-acetyltransferase activity cytoplasm
YOL006C YOL006C TOP1 hom Verified 0.686197237461667 0.246294369799947 no 1212 0.245177738841107 836 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|CHROMOSOME SEGREGATION|GENE SILENCING NUCLEUS|CHROMOSOME Topoisomerase I, nuclear enzyme that relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone; relaxes both positively and negatively supercoiled DNA; functions in replication, transcription, and recombination nuclear migration|chromatin assembly or disassembly|DNA topological change|DNA strand elongation involved in DNA replication|regulation of mitotic recombination|chromatin silencing at rDNA|regulation of transcription from RNA polymerase II promoter|mitotic chromosome condensation|transcription elongation from RNA polymerase II promoter DNA topoisomerase type I activity replication fork protection complex|nucleolus|nucleus
YJR153W YJR153W PGU1 hom Verified 0.685221087748282 0.246602209405898 no 1213 0.223369759874996 711 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM Endo-polygalacturonase, pectolytic enzyme that hydrolyzes the alpha-1,4-glycosidic bonds in the rhamnogalacturonan chains in pectins pseudohyphal growth|pectin catabolic process polygalacturonase activity extracellular region
YGL252C YGL252C RTG2 hom Verified 0.685171336559928 0.246617904511082 no 1214 0.265586817277714 926 NA FT PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|SIGNALING|RESPONSE TO NUTRIENT LEVELS NUCLEUS|CHROMOSOME HISTONE ACETYLTRANSFERASE Sensor of mitochondrial dysfunction; regulates the subcellular location of Rtg1p and Rtg3p, transcriptional activators of the retrograde (RTG) and TOR pathways; Rtg2p is inhibited by the phosphorylated form of Mks1p maintenance of DNA trinucleotide repeats|regulation of transcription from RNA polymerase II promoter|Unknown|nitrogen catabolite regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|mitochondria-nucleus signaling pathway|transcription factor import into nucleus RNA polymerase II transcription factor binding transcription factor activity SLIK (SAGA-like) complex|transcriptionally active chromatin|cytoplasm
YMR274C YMR274C RCE1 hom Verified 0.685073003856103 0.246648927296203 no 1215 0.252726967186363 876 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Type II CAAX prenyl protease involved in the proteolysis and maturation of Ras and the a-factor mating pheromone CAAX-box protein processing|peptide pheromone maturation|protein processing metalloendopeptidase activity integral to endoplasmic reticulum membrane|integral to membrane
YKL086W YKL086W SRX1 hom Verified 0.684998915703572 0.24667230259758 no 1216 0.239539911149572 821 NA FT OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS NUCLEUS Sulfiredoxin; contributes to oxidative stress resistance by reducing cysteine-sulfinic acid groups in the peroxiredoxin Tsa1p, which is formed upon exposure to oxidants; conserved in higher eukaryotes; protein abundance increases in response to DNA replication stress cellular response to oxidative stress sulfiredoxin activity nucleus|cytoplasm
YHL047C YHL047C ARN2 hom Verified 0.684996128051115 0.246673182143497 no 1217 0.241765755086114 825 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS|COFACTOR METABOLISM PLASMA MEMBRANE Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to the siderophore triacetylfusarinine C cellular iron ion homeostasis|siderophore transport|siderophore metabolic process siderophore transmembrane transporter activity endosome|integral to membrane|cytoplasmic membrane-bounded vesicle|plasma membrane
YOL046C_d YOL046C YOL046C hom Dubious 0.684136914238339 0.246944356932126 no 1218 0.219723703606264 750 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data;almost completely overlaps the verified gene PSK2/YOL045W Unknown Unknown Unknown
YDL159W-A_p YDL159W-A YDL159W-A hom Uncharacterized 0.68373811011107 0.247070276907644 no 1219 0.238080826082106 827 NA Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species biological_process molecular_function cellular_component
YPL096C-A YPL096C-A ERI1 hom Verified 0.683732184859288 0.247072148028747 no 1220 0.280827892534207 976 NA FT LIPID METABOLISM|SIGNALING ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Endoplasmic reticulum membrane protein that binds to and inhibits GTP-bound Ras2p at the ER; component of the GPI-GnT complex which catalyzes the first step in GPI-anchor biosynthesis; probable homolog of mammalian PIG-Y protein GPI anchor biosynthetic process|Ras protein signal transduction GTPase inhibitor activity glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex|endoplasmic reticulum membrane
YOR051C YOR051C ETT1 hom Verified 0.683721188825185 0.247075620460172 no 1221 0.231679139704213 790 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION NUCLEUS Nuclear protein that inhibits replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts; deletion increases stop codon readthrough translational termination molecular_function nucleus
YOR327C YOR327C SNC2 hom Verified 0.679936475626638 0.248272342254008 no 1222 0.25100846007342 875 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Vesicle membrane receptor protein (v-SNARE); involved in the fusion between Golgi-derived secretory vesicles with the plasma membrane; member of the synaptobrevin/VAMP family of R-type v-SNARE proteins; SNC2 has a paralog, SNC1, that arose from the whole genome duplication endocytosis|exocytosis|Golgi to plasma membrane transport|vesicle fusion SNAP receptor activity SNARE complex|trans-Golgi network|endosome|transport vesicle membrane
YGR291C_d YGR291C YGR291C hom Dubious 0.679127572542067 0.248528516709602 no 1223 0.258808321067561 854 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YIL154C YIL154C IMP2' hom Verified 0.677688744881678 0.248984532091689 no 1224 0.304415278269704 1072 NA FF|FT RESPONSE TO DNA DAMAGE|ION HOMEOSTASIS|CARBOHYDRATE METABOLISM|ION HOMEOSTASIS Transcriptional activator involved in maintenance of ion homeostasis and protection against DNA damage caused by bleomycin and other oxidants, contains a C-terminal leucine-rich repeat DNA repair|cellular carbohydrate metabolic process transcription coactivator activity cytoplasm
YGR221C YGR221C TOS2 hom Verified 0.677681643459307 0.248986783887314 no 1225 0.239155662410329 828 NA FT CELL DIVISION SITE OF POLARIZED GROWTH|PLASMA MEMBRANE Protein involved in localization of Cdc24p to the site of bud growth; may act as a membrane anchor; localizes to the bud neck and bud tip; potentially phosphorylated by Cdc28p budding cell bud growth molecular_function cellular bud neck|cellular bud tip
YBL065W_d YBL065W YBL065W hom Dubious 0.677167500607865 0.249149842640259 no 1226 0.264827580353467 865 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF SEF1/YBL066C; YBL065W is a non-essential gene Unknown Unknown Unknown
YGL108C YGL108C YGL108C hom Verified 0.675963366587612 0.249531952047214 no 1227 0.244177993573349 850 NA Protein of unknown function, predicted to be palmitoylated; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; protein abundance increases in response to DNA replication stress biological_process molecular_function cellular_component
YLR055C YLR055C SPT8 hom Verified 0.673140187466777 0.250429054535831 no 1228 0.259243823126035 912 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION NUCLEUS HISTONE ACETYLTRANSFERASE Subunit of the SAGA transcriptional regulatory complex but not present in SAGA-like complex SLIK/SALSA, required for SAGA-mediated inhibition at some promoters histone acetylation|negative regulation of transcription from RNA polymerase II promoter|chromatin modification|positive regulation of transcription from RNA polymerase II promoter TBP-class protein binding|transcription cofactor activity nucleus|SAGA complex
YKL074C YKL074C MUD2 hom Verified 0.669911531619232 0.251457094089528 no 1229 0.219345699922317 746 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING NUCLEUS Protein involved in early pre-mRNA splicing; component of the pre-mRNA-U1 snRNP complex, the commitment complex; interacts with Msl5p/BBP splicing factor and Sub2p; similar to metazoan splicing factor U2AF65 mRNA branch site recognition pre-mRNA branch point binding commitment complex
YBR245C YBR245C ISW1 hom Verified 0.665741073351691 0.252788307687994 no 1230 0.241175048799443 851 NA FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS|CHROMOSOME ATPase subunit of imitation-switch (ISWI) class chromatin remodelers; ATPase; forms a complex with Ioc3p (Isw1a), and a complex with Ioc2p and Ioc4p (Isw1b); Isw1a and Isw1b have partially overlapping and distinct roles, Isw1a involved in repression of transcription initiation and Isw1b involved in regulation of transcription elongation; Isw1b recruited to open reading frames by H3K36 methylation and acts with Chd1p to prevent trans-histone exchange over coding regions termination of RNA polymerase I transcription|nucleosome positioning|termination of RNA polymerase II transcription|regulation of transcription by chromatin organization|DNA-dependent transcription, elongation|regulation of transcriptional start site selection at RNA polymerase II promoter|heterochromatin maintenance involved in chromatin silencing|chromatin remodeling|positive regulation of transcription from RNA polymerase II promoter nucleosome binding|ATPase activity|rDNA binding|DNA binding ISW1 complex|nucleolar chromatin
YKL071W_p YKL071W YKL071W hom Uncharacterized 0.665553122356504 0.252848389051468 no 1231 0.257828999012739 880 NA FT OXIDATION-REDUCTION PROCESS Putative protein of unknown function; expression induced in cells treated with the mycotoxin patulin, and also the quinone methide triterpene celastrol; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm biological_process molecular_function integral to membrane|cytoplasm
YJL134W YJL134W LCB3 hom Verified 0.665059884783327 0.253006095603432 no 1232 0.245749293963706 813 NA FT LIPID METABOLISM|SIGNALING ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Long-chain base-1-phosphate phosphatase; specific for dihydrosphingosine-1-phosphate, regulates ceramide and long-chain base phosphates levels, involved in incorporation of exogenous long chain bases in sphingolipids; LCB3 has a paralog, YSR3, that arose from the whole genome duplication calcium-mediated signaling|sphingolipid biosynthetic process sphingosine-1-phosphate phosphatase activity integral to membrane|endoplasmic reticulum
YGR193C YGR193C PDX1 hom Verified 0.664102837756316 0.253312247013246 no 1233 0.22182585013077 776 NA FT KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION Dihydrolipoamide dehydrogenase (E3)-binding protein (E3BP) of the mitochondrial pyruvate dehydrogenase (PDH) complex, plays a structural role in the complex by binding and positioning E3 to the dihydrolipoamide acetyltransferase (E2) core acetyl-CoA biosynthetic process from pyruvate structural molecule activity mitochondrion|mitochondrial pyruvate dehydrogenase complex
YER143W YER143W DDI1 hom Verified 0.66401869643226 0.253339172436154 no 1234 0.222212493571411 755 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEOLYSIS PLASMA MEMBRANE DNA damage-inducible v-SNARE binding protein with a role in suppression of protein secretion; may play a role in S-phase checkpoint control; has ubiquitin-associated (UBA), ubiquitin-like (UBL), and retroviral-like proteinase (RVP) domains vesicle-mediated transport|protein secretion|ubiquitin-dependent protein catabolic process ubiquitin binding|SNARE binding|aspartic-type endopeptidase activity plasma membrane
YHR063C YHR063C PAN5 hom Verified 0.663672968765825 0.253449821896924 no 1235 0.270083627789564 917 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM 2-dehydropantoate 2-reductase, part of the pantothenic acid pathway, structurally homologous to E. coli panE pantothenate biosynthetic process 2-dehydropantoate 2-reductase activity cytoplasm
YBL029W_p YBL029W YBL029W hom Uncharacterized 0.663293063262778 0.253571439187634 no 1236 0.266226027237196 912 NA FT NUCLEUS Non-essential protein of unknown function biological_process molecular_function nucleus|cytoplasm
YHL002W YHL002W HSE1 hom Verified 0.662838385322872 0.253717033304462 no 1237 0.264840541673101 878 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT Subunit of the endosomal Vps27p-Hse1p complex required for sorting of ubiquitinated membrane proteins into intralumenal vesicles prior to vacuolar degradation, as well as for recycling of Golgi proteins and formation of lumenal membranes late endosome to vacuole transport|protein targeting to vacuole ubiquitin binding endosome|ESCRT-0 complex
YKR048C YKR048C NAP1 hom Verified 0.66152791273602 0.254136910077059 no 1238 0.26363493713684 915 NA FT PROTEIN LOCALIZATION|CELL CYCLE|CHROMATIN ORGANIZATION|CELL DIVISION NUCLEUS|SITE OF POLARIZED GROWTH|CHROMOSOME Protein that interacts with mitotic cyclin Clb2p; required for the regulation of microtubule dynamics during mitosis; controls bud morphogenesis; involved in the transport of H2A and H2B histones to the nucleus; phosphorylated by CK2; protein abundance increases in response to DNA replication stress budding cell bud growth|M phase of mitotic cell cycle|nucleosome disassembly|protein import into nucleus|nucleosome assembly cyclin binding|histone binding nucleus|nuclear nucleosome|cytoplasm
YNL054W YNL054W VAC7 hom Verified 0.661371371537647 0.254187090394923 no 1239 0.202796445059567 707 NA FT LIPID METABOLISM Integral vacuolar membrane protein involved in vacuole inheritance and morphology; activates Fab1p kinase activity under basal conditions and also after hyperosmotic shock positive regulation of phosphatidylinositol biosynthetic process|positive regulation of kinase activity molecular_function fungal-type vacuole membrane|integral to membrane|PAS complex|vacuolar membrane|cytoplasm
YAL051W YAL051W OAF1 hom Verified 0.661206845304799 0.254239835968278 no 1240 0.244288679588689 799 NA FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|GENE SILENCING NUCLEUS Oleate-activated transcription factor; acts alone and as a heterodimer with Pip2p; activates genes involved in beta-oxidation of fatty acids and peroxisome organization and biogenesis; OAF1 has a paralog, PIP2, that arose from the whole genome duplication cellular response to oleic acid|positive regulation of fatty acid beta-oxidation|positive regulation of chromatin silencing at telomere|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus
YDR123C YDR123C INO2 hom Verified 0.660922620087746 0.254330969436539 no 1241 0.264014326945511 905 NA FT TRANSCRIPTION FROM RNA POL II|LIPID METABOLISM NUCLEUS Component of the heteromeric Ino2p/Ino4p basic helix-loop-helix transcription activator that binds inositol/choline-responsive elements (ICREs), required for derepression of phospholipid biosynthetic genes in response to inositol depletion phospholipid biosynthetic process|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus
YPL270W YPL270W MDL2 hom Verified 0.66041495451979 0.254493789019937 no 1242 0.262796980039573 922 NA FT NUCLEOTIDE METABOLISM MITOCHONDRION Mitochondrial inner membrane half-type ATP-binding cassette (ABC) transporter, required for respiratory growth at high temperature; similar to human TAP1 and TAP2 implicated in bare lymphocyte syndrome and Wegener-like granulomatosis oligopeptide transport|oligopeptide export from mitochondrion oligopeptide-transporting ATPase activity mitochondrion|integral to membrane|mitochondrial inner membrane
YGR070W YGR070W ROM1 hom Verified 0.660410605380613 0.254495184121032 no 1243 0.266299494629517 942 NA FT SIGNALING|NUCLEOTIDE METABOLISM GDP/GTP exchange protein (GEP) for Rho1p; mutations are synthetically lethal with mutations in rom2, which also encodes a GEP small GTPase mediated signal transduction|activation of Rho GTPase activity Rho guanyl-nucleotide exchange factor activity intracellular
YML059C YML059C NTE1 hom Verified 0.659821089966325 0.254684323814355 no 1244 0.254417411086515 861 NA FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Serine esterase, homolog of human neuropathy target esterase (NTE); Nte1p-mediated phosphatidylcholine turnover influences transcription factor Opi1p localization, affecting transcriptional regulation of phospholipid biosynthesis genes phosphatidylcholine catabolic process|regulation of phospholipid biosynthetic process lysophospholipase activity|carboxylesterase activity integral to membrane|endoplasmic reticulum
YLR144C YLR144C ACF2 hom Verified 0.657966649916575 0.255279780642464 no 1245 0.250970725078739 872 NA FT CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION Intracellular beta-1,3-endoglucanase; expression is induced during sporulation; may have a role in cortical actin cytoskeleton assembly; protein abundance increases in response to DNA replication stress actin cytoskeleton organization glucan endo-1,3-beta-D-glucosidase activity intracellular
YNL122C_p YNL122C YNL122C hom Uncharacterized 0.657498915103833 0.255430084167664 no 1246 0.249999679274407 853 NA FT TRANSLATION MITOCHONDRION Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL122C is not an essential gene biological_process molecular_function mitochondrion
YLR194C YLR194C YLR194C hom Verified 0.657060769692739 0.255570921268704 no 1247 0.251165493590761 850 NA FT CELL WALL ORG/BIOGENESIS PLASMA MEMBRANE Structural constituent of the cell wall attached to the plasma membrane by a GPI-anchor; expression is upregulated in response to cell wall stress fungal-type cell wall organization structural constituent of cell wall fungal-type cell wall|anchored to plasma membrane
YLR077W YLR077W FMP25 hom Verified 0.656781348921873 0.255660759229401 no 1248 0.262625918529721 898 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial inner membrane protein required for an early step in assembly of respiratory complex III (cytochrome bc1 complex); mRNA is targeted to mitochondria mitochondrial respiratory chain complex III assembly molecular_function mitochondrion|integral to mitochondrial inner membrane
YDL133C-A YDL133C-A RPL41B hom Verified 0.65593544485551 0.255932830548279 no 1249 0.24137850816523 855 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L41B; comprises only 25 amino acids; rpl41a rpl41b double null mutant is viable; homologous to mammalian ribosomal protein L41, no bacterial homolog; RPL41B has a paralog, RPL41A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YJR024C YJR024C MDE1 hom Verified 0.655674047380597 0.256016935351111 no 1250 0.242466042120939 828 NA FT KETONE METABOLISM|AMINO ACID METABOLISM 5'-methylthioribulose-1-phosphate dehydratase; acts in the methionine salvage pathway; potential Smt3p sumoylation substrate; expression downregulated by caspofungin and deletion mutant is caspofungin resistant L-methionine salvage from methylthioadenosine methylthioribulose 1-phosphate dehydratase activity cytoplasm
YNL111C YNL111C CYB5 hom Verified 0.654798034207063 0.256298898234497 no 1251 0.298775842234521 1031 NA FF|FT LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Cytochrome b5, involved in the sterol and lipid biosynthesis pathways; acts as an electron donor to support sterol C5-6 desaturation sterol biosynthetic process electron carrier activity endoplasmic reticulum membrane
YPL176C YPL176C TRE1 hom Verified 0.652477212829419 0.257046684137374 no 1252 0.270916116113658 934 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEOLYSIS|VACUOLAR TRANSPORT PLASMA MEMBRANE Transferrin receptor-like protein; plasma membrane protein that binds Bsd2p and regulates ubiquitylation and vacuolar degradation of the metal transporter Smf1p; functionally redundant with Tre2p; TRE1 has a paralog, TRE2, that arose from the whole genome duplication protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway molecular_function fungal-type vacuole
YOR171C YOR171C LCB4 hom Verified 0.650992354824534 0.257525711024099 no 1253 0.233679046469318 789 NA FT LIPID METABOLISM|SIGNALING|PROTEIN PHOSPHORYLATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS|PLASMA MEMBRANE Sphingoid long-chain base kinase, responsible for synthesis of long-chain base phosphates, which function as signaling molecules, regulates synthesis of ceramide from exogenous long-chain bases, localizes to the Golgi and late endosomes calcium-mediated signaling|sphingolipid metabolic process D-erythro-sphingosine kinase activity Golgi apparatus|endoplasmic reticulum|plasma membrane|cortical endoplasmic reticulum
YGL003C YGL003C CDH1 hom Verified 0.65051207492875 0.257680752286238 no 1254 0.263894095798212 919 NA FT CELL CYCLE|CELL DIVISION|PROTEOLYSIS|CYTOSKELETON ORGANIZATION NUCLEUS UBIQUITIN LIGASE COMPLEX Cell-cycle regulated activator of the anaphase-promoting complex/cyclosome (APC/C), which directs ubiquitination of cyclins resulting in mitotic exit; targets the APC/C to specific substrates including Cdc20p, Ase1p, Cin8p and Fin1p activation of mitotic anaphase-promoting complex activity|negative regulation of spindle pole body separation|positive regulation of mitotic metaphase/anaphase transition|Unknown|regulation of cell size anaphase-promoting complex binding|cyclin binding|ubiquitin-protein ligase activator activity nucleus|anaphase-promoting complex|cytoplasm
YLR367W YLR367W RPS22B hom Verified 0.650155035380879 0.257796041186146 no 1255 0.248293341782479 847 NA FT TRANSLATION RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22B has a paralog, RPS22A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic small ribosomal subunit
YDR525W-A YDR525W-A SNA2 hom Verified 0.648976515658605 0.258176777879358 no 1256 0.257443632231391 907 NA Protein of unknown function, has similarity to Pmp3p, which is involved in cation transport; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern biological_process molecular_function fungal-type vacuole membrane|integral to membrane|cytoplasm
YNL092W_p YNL092W YNL092W hom Uncharacterized 0.64828279822023 0.258401028880994 no 1257 0.240343371263501 809 NA Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; YNL092W is not an essential gene biological_process S-adenosylmethionine-dependent methyltransferase activity cellular_component
YGL042C_d YGL042C YGL042C hom Dubious 0.646436119238489 0.258998477573425 no 1258 0.259611597581316 909 NA Dubious open reading frame, not conserved in closely related Saccharomyces species; deletion mutation blocks replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene DST1 Unknown Unknown Unknown
YML109W YML109W ZDS2 hom Verified 0.646078811104046 0.259114158485084 no 1259 0.225608554342942 742 NA FT PROTEIN LOCALIZATION|CELL CYCLE|GENE SILENCING NUCLEUS|SITE OF POLARIZED GROWTH Protein with a role in regulating Swe1p-dependent polarized growth; involved in maintenance of Cdc55p in the cytoplasm where it promotes mitotic entry; interacts with silencing proteins at the telomere; implicated in the mitotic exit network through regulation of Cdc14p localization; ZDS2 has a paralog, ZDS1, that arose from the whole genome duplication positive regulation of G2/M transition of mitotic cell cycle|cell shape checkpoint|establishment of cell polarity|regulation of protein localization|chromatin silencing at rDNA|cell aging molecular_function nucleus|cellular bud neck|cellular bud tip|cytoplasm
YNL333W YNL333W SNZ2 hom Verified 0.643854572235748 0.25983487104138 no 1260 0.258153209175439 893 NA FT COFACTOR METABOLISM Member of a stationary phase-induced gene family; transcription of SNZ2 is induced prior to diauxic shift, and also in the absence of thiamin in a Thi2p-dependent manner; forms a coregulated gene pair with SNO2; interacts with Thi11p pyridoxine metabolic process|thiamine biosynthetic process protein binding cellular_component
YPL248C YPL248C GAL4 hom Verified 0.643027554840876 0.260103110203217 no 1261 0.245927940140481 851 NA FT TRANSCRIPTION FROM RNA POL II|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS NUCLEUS DNA-binding transcription factor required for the activation of the GAL genes in response to galactose; repressed by Gal80p and activated by Gal3p galactose metabolic process|positive regulation of transcription from RNA polymerase II promoter by galactose RNA polymerase II transcription factor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity nucleus
YGL255W YGL255W ZRT1 hom Verified 0.642173691090412 0.260380206560776 no 1262 0.230241448898666 768 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE High-affinity zinc transporter of the plasma membrane, responsible for the majority of zinc uptake; transcription is induced under low-zinc conditions by the Zap1p transcription factor high-affinity zinc ion transport high affinity zinc uptake transmembrane transporter activity integral to membrane|integral to plasma membrane
YJR095W YJR095W SFC1 hom Verified 0.641876852951492 0.260476572252484 no 1263 0.250084017893643 861 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION Mitochondrial succinate-fumarate transporter, transports succinate into and fumarate out of the mitochondrion; required for ethanol and acetate utilization succinate transport|fumarate transport succinate:fumarate antiporter activity mitochondrion|integral to membrane|mitochondrial inner membrane
YIL112W YIL112W HOS4 hom Verified 0.641057542431647 0.260742648928936 no 1264 0.243436726882114 839 NA FT CELL CYCLE|CHROMATIN ORGANIZATION NUCLEUS|CHROMOSOME Subunit of the Set3 complex, which is a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity; potential Cdc28p substrate negative regulation of meiosis|histone deacetylation molecular_function Set3 complex
YFL050C YFL050C ALR2 hom Verified 0.639605583648089 0.261214525745025 no 1265 0.273563196821405 938 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE Probable Mg(2+) transporter; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions; plays a role in regulating Ty1 transposition magnesium ion transport|cation transport|transmembrane transport inorganic cation transmembrane transporter activity integral to membrane|plasma membrane
YDR297W YDR297W SUR2 hom Verified 0.638892223081628 0.261446523772631 no 1266 0.276125583576103 948 NA FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Sphinganine C4-hydroxylase, catalyses the conversion of sphinganine to phytosphingosine in sphingolipid biosyntheis sphingolipid metabolic process sphingosine hydroxylase activity integral to membrane|endoplasmic reticulum membrane
YPL009C YPL009C TAE2 hom Verified 0.637899026283463 0.261769705822234 no 1267 0.260627746542962 903 NA FT TRANSLATION Protein of unknown function, involved in protein translation; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm cytoplasmic translation molecular_function ribosome|cytoplasm
YLR136C YLR136C TIS11 hom Verified 0.637762972614903 0.261813993066867 no 1268 0.247448582715034 852 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS NUCLEUS mRNA-binding protein expressed during iron starvation; binds to a sequence element in the 3'-untranslated regions of specific mRNAs to mediate their degradation; involved in iron homeostasis; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress cellular iron ion homeostasis|nuclear-transcribed mRNA catabolic process mRNA binding nucleus|cytoplasm
YNL197C YNL197C WHI3 hom Verified 0.637217665007573 0.261991536373238 no 1269 0.264590077413878 940 NA FT PROTEIN LOCALIZATION|CELL CYCLE RNA binding protein that sequesters CLN3 mRNA in cytoplasmic foci;; Tpk1 (PKA) mediated phosphorylation of Whi3 affects G1/S transition by modulating Cln3 transcription; cytoplasmic retention factor for Cdc28p and associated cyclins; regulates cell fate and dose-dependently regulates the critical cell size required for passage through Start; WHI3 has a paralog, WHI4, that arose from the whole genome duplication pseudohyphal growth|invasive growth in response to glucose limitation|regulation of cell size|cytoplasmic sequestering of protein RNA binding cytoplasm
YGR213C YGR213C RTA1 hom Verified 0.636929287416002 0.26208545238218 no 1270 0.230445967367996 771 NA FT PLASMA MEMBRANE Protein involved in 7-aminocholesterol resistance; has seven potential membrane-spanning regions; expression is induced under both low-heme and low-oxygen conditions; member of the fungal lipid-translocating exporter (LTE) family of protein biological_process molecular_function integral to membrane|plasma membrane
YOR306C YOR306C MCH5 hom Verified 0.635792611385454 0.262455801945514 no 1271 0.24601587624293 827 NA FT PLASMA MEMBRANE Plasma membrane riboflavin transporter; facilitates the uptake of vitamin B2; required for FAD-dependent processes; sequence similarity to mammalian monocarboxylate permeases, however mutants are not deficient in monocarboxylate transport riboflavin transport monocarboxylic acid transmembrane transporter activity|riboflavin transporter activity integral to membrane|plasma membrane
YLR004C YLR004C THI73 hom Verified 0.635695484215883 0.262487460150801 no 1272 0.240689246877612 812 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|PLASMA MEMBRANE Putative plasma membrane permease proposed to be involved in carboxylic acid uptake and repressed by thiamine; substrate of Dbf2p/Mob1p kinase; transcription is altered if mitochondrial dysfunction occurs transport transporter activity integral to membrane|endoplasmic reticulum
YDL138W YDL138W RGT2 hom Verified 0.635187743882423 0.262652987858719 no 1273 0.235260609264133 763 NA FT SIGNALING PLASMA MEMBRANE Plasma membrane high glucose sensor that regulates glucose transport; contains 12 predicted transmembrane segments and a long C-terminal tail required for induction of hexose transporters; RGT2 has a paralog, SNF3, that arose from the whole genome duplication glucose transport|signal transduction|detection of glucose glucose transmembrane transporter activity|receptor activity|glucose binding integral to membrane|plasma membrane
YAR020C YAR020C PAU7 hom Verified 0.633229117525306 0.263292016881733 no 1274 0.265494534499467 891 NA Member of the seripauperin multigene family, active during alcoholic fermentation, regulated by anaerobiosis, inhibited by oxygen, repressed by heme biological_process molecular_function cellular_component
YOR201C YOR201C MRM1 hom Verified 0.632602491089145 0.263496629969039 no 1275 0.267595781770237 899 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS MITOCHONDRION Ribose methyltransferase that modifies a functionally critical, conserved nucleotide in mitochondrial 21S rRNA rRNA modification rRNA (guanine-N1-)-methyltransferase activity mitochondrion
YGL160W YGL160W AIM14 hom Verified 0.632187775385161 0.263632092204319 no 1276 0.269209217291377 918 NA FT ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|GEN. OF PRECURSOR METABOLITES AND ENERGY NADPH oxidase localized to the perinuclear ER; produces superoxide from NADPH; overexpression causes MCA1 dependent apoptosis; likely involved in superoxide-mediated regulation of the actin cytoskeleton; member of a conserved superfamily of NADPH oxidases (NOX enzymes); has similarity to iron/copper reductases (FRE1-8), particularly Fre8p biological_process oxidoreductase activity, oxidizing metal ions integral to membrane|ribosome
YDR215C_d YDR215C YDR215C hom Dubious 0.63203318275674 0.26368259724217 no 1277 0.265426378920116 862 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays elevated sensitivity to expression of a mutant huntingtin fragment or of alpha-synuclein Unknown Unknown Unknown
YPL139C YPL139C UME1 hom Verified 0.631850416099139 0.263742313033162 no 1278 0.265808384472463 931 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS|CHROMOSOME Negative regulator of meiosis, required for repression of a subset of meiotic genes during vegetative growth, binding of histone deacetylase Rpd3p required for activity, contains a NEE box and a WD repeat motif; homologous with Wtm1p, Wtm2p positive regulation of transcription from RNA polymerase II promoter in response to heat stress|negative regulation of transcription from RNA polymerase I promoter|negative regulation of chromatin silencing at telomere|positive regulation of transcription from RNA polymerase II promoter|regulation of meiosis transcription corepressor activity Rpd3S complex|Rpd3L-Expanded complex|nucleus|Rpd3L complex
YBR071W YBR071W YBR071W hom Verified 0.631367864765789 0.263900011333061 no 1279 0.25639930579135 852 NA FT SITE OF POLARIZED GROWTH Protein of unknown function found in the cytoplasm and bud neck; mRNA expression may be regulated by the cell cycle and/or cell wall stress; overexpression of YBR071W affects endocytic protein trafficking biological_process molecular_function cellular bud neck|cytoplasm
YBR248C YBR248C HIS7 hom Verified 0.630694699445175 0.264120082760247 no 1280 0.253013125621335 865 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEOTIDE METABOLISM Imidazole glycerol phosphate synthase (glutamine amidotransferase:cyclase), catalyzes the fifth step of histidine biosynthesis and also produces 5-aminoimidazole-4-carboxamide ribotide (AICAR), a purine precursor purine nucleoside monophosphate biosynthetic process|histidine biosynthetic process imidazoleglycerol-phosphate synthase activity intracellular
YDL090C YDL090C RAM1 hom Verified 0.630338213083999 0.264236663251252 no 1281 0.321200436091636 1110 NA FF|FT PROTEIN PRENYLATION Beta subunit of the CAAX farnesyltransferase (FTase) that prenylates the a-factor mating pheromone and Ras proteins; required for the membrane localization of Ras proteins and a-factor; homolog of the mammalian FTase beta subunit protein farnesylation protein farnesyltransferase activity protein farnesyltransferase complex
YDR055W YDR055W PST1 hom Verified 0.630182840060764 0.264287482547391 no 1282 0.260655693231944 868 NA FT CELL WALL ORG/BIOGENESIS PLASMA MEMBRANE Cell wall protein that contains a putative GPI-attachment site; secreted by regenerating protoplasts; up-regulated by activation of the cell integrity pathway, as mediated by Rlm1p; upregulated by cell wall damage via disruption of FKS1 fungal-type cell wall organization molecular_function fungal-type cell wall|plasma membrane
YPL060W YPL060W MFM1 hom Verified 0.629867652227025 0.264390589241538 no 1283 0.29147586389035 991 NA FT RNA PROCESSING|ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION Mitochondrial inner membrane magnesium transporter, involved in maintenance of mitochondrial magnesium concentrations and membrane potential; indirectly affects splicing of group II introns; functionally and structurally related to Mrs2p mitochondrial magnesium ion transport magnesium ion transmembrane transporter activity integral to membrane|mitochondrial inner membrane
YHL022C YHL022C SPO11 hom Verified 0.629494461229753 0.264512696849972 no 1284 0.221028817610151 779 NA FT CELL CYCLE NUCLEUS|CHROMOSOME Meiosis-specific protein that initiates meiotic recombination by catalyzing the formation of double-strand breaks in DNA via a transesterification reaction; required for homologous chromosome pairing and synaptonemal complex formation meiotic DNA double-strand break formation endodeoxyribonuclease activity, producing 3'-phosphomonoesters nuclear chromosome
YER144C YER144C UBP5 hom Verified 0.629445300575737 0.264528784290718 no 1285 0.265596319483258 921 NA FT PROTEOLYSIS SITE OF POLARIZED GROWTH Putative ubiquitin-specific protease, closest paralog of Doa4p but has no functional overlap; concentrates at the bud neck protein deubiquitination ubiquitin-specific protease activity incipient cellular bud site|cellular bud neck
YDR354W YDR354W TRP4 hom Verified 0.628633520914445 0.264794504818842 no 1286 0.413897225246088 1387 NA FF|FT KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS Anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosphoribosylation of anthranilate, subject to the general control system of amino acid biosynthesis tryptophan biosynthetic process anthranilate phosphoribosyltransferase activity nucleus|cytoplasm
YGR112W YGR112W SHY1 hom Verified 0.62785571100711 0.265049233239877 no 1287 0.239659665837289 816 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Mitochondrial inner membrane protein required for assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes; similar to human SURF1 involved in Leigh Syndrome mitochondrial respiratory chain complex IV assembly|aerobic respiration unfolded protein binding mitochondrion|integral to membrane|mitochondrial inner membrane
YKR035W-A YKR035W-A DID2 hom Verified 0.627735769378483 0.26508852453189 no 1288 0.265024942430827 895 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM Class E protein of the vacuolar protein-sorting (Vps) pathway; binds Vps4p and directs it to dissociate ESCRT-III complexes; forms a functional and physical complex with Ist1p; human ortholog may be altered in breast tumors late endosome to vacuole transport via multivesicular body sorting pathway|late endosome to vacuole transport|protein targeting to vacuole molecular_function late endosome|cytoplasm
YPL019C YPL019C VTC3 hom Verified 0.627610369539731 0.265129607024807 no 1289 0.238782138527438 799 NA FT MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT ENDOPLASMIC RETICULUM Subunit of the vacuolar transporter chaperone (VTC) complex involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion polyphosphate metabolic process|vacuolar transport|microautophagy|vacuole fusion, non-autophagic molecular_function fungal-type vacuole membrane|integral to membrane|vacuolar transporter chaperone complex|endoplasmic reticulum
YOL058W YOL058W ARG1 hom Verified 0.623372959282319 0.266519731640243 no 1290 0.285867724801011 977 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Arginosuccinate synthetase, catalyzes the formation of L-argininosuccinate from citrulline and L-aspartate in the arginine biosynthesis pathway; potential Cdc28p substrate argininosuccinate metabolic process|arginine biosynthetic process|citrulline metabolic process argininosuccinate synthase activity cytosol
YBR084C-A YBR084C-A RPL19A hom Verified 0.623267113972822 0.26655450237982 no 1291 0.252783224384185 868 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L19A; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal; homologous to mammalian ribosomal protein L19, no bacterial homolog; RPL19A has a paralog, RPL19B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YGL153W YGL153W PEX14 hom Verified 0.622426154387966 0.266830843511445 no 1292 0.265621565917262 909 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|PEROXISOME ORGANIZATION Peroxisomal membrane peroxin that is a central component of the peroxisomal protein import machinery; interacts with both PTS1 (Pex5p) and PTS2 (Pex7p), peroxisomal matrix protein signal recognition factors and membrane receptor Pex13p protein import into peroxisome matrix, docking protein binding, bridging peroxisomal membrane
YPL119C-A_p YPL119C-A YPL119C-A hom Uncharacterized 0.62214335332197 0.266923805065531 no 1293 0.264927635269298 898 NA Putative protein of unknown function; identified by expression profiling and mass spectrometry biological_process molecular_function cellular_component
YJL082W YJL082W IML2 hom Verified 0.621537018481648 0.267123172838462 no 1294 0.25027411770461 850 NA FT NUCLEUS|MITOCHONDRION Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; IML2 has a paralog, YKR018C, that arose from the whole genome duplication biological_process molecular_function mitochondrial outer membrane|mitochondrion|nucleus|cytoplasm
YLR271W_p YLR271W YLR271W hom Uncharacterized 0.620987695607099 0.267303859500748 no 1295 0.24643202880421 833 NA FT NUCLEUS Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS biological_process molecular_function nucleus|cytoplasm
YDR200C YDR200C VPS64 hom Verified 0.61930419254765 0.267857991516564 no 1296 0.317363589947058 1077 NA FT PROTEIN LOCALIZATION|CELL CYCLE|SIGNALING|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Protein required for cytoplasm to vacuole targeting of proteins; forms a complex with Far3p and Far7p to Far11p involved in recovery from pheromone-induced cell cycle arrest; mutant has increased aneuploidy tolerance re-entry into mitotic cell cycle after pheromone arrest|protein targeting to vacuole molecular_function endoplasmic reticulum membrane|cytoplasm
YNL264C YNL264C PDR17 hom Verified 0.618959767539388 0.267971431695859 no 1297 0.271536444278217 952 NA FT LIPID METABOLISM Phosphatidylinositol transfer protein (PITP), downregulates Plb1p-mediated turnover of phosphatidylcholine, found in the cytosol and microsomes, homologous to Pdr16p, deletion affects phospholipid composition Golgi to plasma membrane protein transport|phosphatidylserine metabolic process|response to drug|sterol biosynthetic process|Unknown|phospholipid transport|phospholipid biosynthetic process phosphatidylinositol transporter activity|phosphatidylcholine transporter activity endosome|cell periphery|cytosol|cytoplasm
YER119C YER119C AVT6 hom Verified 0.617099796306051 0.268584451518601 no 1298 0.257624362048257 884 NA FT VACUOLAR TRANSPORT Vacuolar aspartate and glutamate exporter; member of a family of seven genes (AVT1-7) related to vesicular GABA-glycine transporters; involved in compartmentalizing acidic amino acids in response to nitrogen starvation; AVT6 has a paralog, AVT5, that arose from the whole genome duplication amino acid export from vacuole|transmembrane transport L-aspartate transmembrane transporter activity|transporter activity|L-glutamate transmembrane transporter activity fungal-type vacuole membrane|integral to membrane|fungal-type vacuole
YPL188W YPL188W POS5 hom Verified 0.616821271719164 0.26867630986278 no 1299 0.270182829580941 941 NA FT NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS MITOCHONDRION Mitochondrial NADH kinase, phosphorylates NADH; also phosphorylates NAD(+) with lower specificity; required for the response to oxidative stress cellular response to oxidative stress|NADP biosynthetic process NADH kinase activity mitochondrion|mitochondrial matrix
YGL258W YGL258W VEL1 hom Verified 0.616054402206195 0.268929307540211 no 1300 0.296134933266987 1025 NA Protein of unknown function; highly induced in zinc-depleted conditions and has increased expression in NAP1 deletion mutants; VEL1 has paralog YOR387C biological_process molecular_function cytosol
YNR027W YNR027W BUD17 hom Verified 0.614490109068653 0.269445753554442 no 1301 0.280670790979551 974 NA FT CELL CYCLE|CELL DIVISION|COFACTOR METABOLISM NUCLEUS Putative pyridoxal kinase, a key enzyme in vitamin B6 metabolism; involved in bud-site selection; diploid mutants display a random rather than a bipolar budding pattern; similarity to yeast BUD16 and human pyridoxal kinase (PDXK) pyridoxal phosphate biosynthetic process|cellular bud site selection pyridoxal kinase activity nucleus|cytoplasm
YOR034C-A_p YOR034C-A YOR034C-A hom Uncharacterized 0.6134991688721 0.269773166079031 no 1302 0.291661520026292 959 NA Putative protein of unknown function; identified by expression profiling and mass spectrometry biological_process molecular_function cellular_component
YLR112W_d YLR112W YLR112W hom Dubious 0.613383769449834 0.269811307680789 no 1303 0.244799329104087 784 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YGL186C YGL186C TPN1 hom Verified 0.612146672677408 0.270220360144023 no 1304 0.373618630045342 1245 NA FF|FT PLASMA MEMBRANE Plasma membrane pyridoxine (vitamin B6) transporter; member of the purine-cytosine permease subfamily within the major facilitator superfamily; proton symporter with similarity to Fcy21p, Fcy2p, and Fcy22p vitamin transport vitamin transporter activity integral to membrane|plasma membrane
YBR286W YBR286W APE3 hom Verified 0.611519497927675 0.270427857127875 no 1305 0.277257392429707 958 NA FT PROTEOLYSIS Vacuolar aminopeptidase Y, processed to mature form by Prb1p vacuolar protein catabolic process aminopeptidase activity fungal-type vacuole
YDR391C_p YDR391C YDR391C hom Uncharacterized 0.611442312098768 0.270453399095661 no 1306 0.270678306916476 896 NA FT NUCLEUS Putative protein of unknown function, possibly involved in zinc homeostasis; Bdf1p-dependent transcription induced by salt stress; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus biological_process molecular_function nucleus|cytoplasm
YMR088C YMR088C VBA1 hom Verified 0.611284252241978 0.270505707274211 no 1307 0.26865485871467 914 NA Permease of basic amino acids in the vacuolar membrane basic amino acid transport basic amino acid transmembrane transporter activity fungal-type vacuole membrane|integral to membrane
YGR174W-A_p YGR174W-A YGR174W-A hom Uncharacterized 0.610234431671357 0.270853262124302 no 1308 0.248044430194929 837 NA Putative protein of unknown function; predicted to have a role in cell budding based on computational guilt by association analysis biological_process molecular_function cellular_component
YLR423C YLR423C ATG17 hom Verified 0.609692504121308 0.27103276048298 no 1309 0.284696333024052 972 NA FT MEMBRANE ORGANIZATION|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS|PEROXISOME ORGANIZATION Scaffold protein responsible for phagophore assembly site organization; regulatory subunit of an autophagy-specific complex that includes Atg1p and Atg13p; stimulates Atg1p kinase activity; human ortholog RB1CC1/FIP200 interacts with p53, which inhibits autophagy in human cells piecemeal microautophagy of nucleus|mitochondrion degradation|peroxisome degradation|activation of protein kinase activity|autophagic vacuole assembly protein kinase activator activity|protein complex scaffold pre-autophagosomal structure|Atg1p signaling complex
YDR480W YDR480W DIG2 hom Verified 0.609554417188001 0.271078507405527 no 1310 0.257584133848215 892 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS MAP kinase-responsive inhibitor of the Ste12p transcription factor, involved in the regulation of mating-specific genes and the invasive growth pathway; related regulators Dig1p and Dig2p bind to Ste12p negative regulation of transcription from RNA polymerase II promoter by pheromones|Unknown transcription factor binding nucleus
YOR028C YOR028C CIN5 hom Verified 0.608559622745779 0.271408187356776 no 1311 0.244416124784952 814 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Basic leucine zipper (bZIP) transcription factor of the yAP-1 family; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; mediates pleiotropic drug resistance and salt tolerance; nuclearly localized under oxidative stress and sequestered in the cytoplasm by Lot6p under reducing conditions; CIN5 has a paralog, YAP6, that arose from the whole genome duplication hyperosmotic salinity response|response to drug|hyperosmotic response|regulation of transcription from RNA polymerase II promoter repressing transcription factor binding|sequence-specific DNA binding nucleus|cytoplasm
YGR085C YGR085C RPL11B hom Verified 0.608361842735919 0.27147375645923 no 1312 0.29957129721313 1016 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Ribosomal 60S subunit protein L11B; expressed at half the level of Rpl11Ap; involved in ribosomal assembly; depletion causes degradation of 60S proteins and RNA; homologous to mammalian ribosomal protein L11 and bacterial L5; RPL11B has a paralog, RPL11A, that arose from the whole genome duplication cytoplasmic translation|ribosomal large subunit assembly structural constituent of ribosome cytosolic large ribosomal subunit
YLL010C YLL010C PSR1 hom Verified 0.608228789971947 0.271517871273103 no 1313 0.284587163680404 976 NA FT PLASMA MEMBRANE Plasma membrane associated protein phosphatase involved in the general stress response; required along with binding partner Whi2p for full activation of STRE-mediated gene expression, possibly through dephosphorylation of Msn2p response to stress phosphoprotein phosphatase activity plasma membrane
YDR178W YDR178W SDH4 hom Verified 0.60719402044987 0.271861080022051 no 1314 0.300845249497298 1022 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION Membrane anchor subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain mitochondrial electron transport, succinate to ubiquinone|cellular respiration|tricarboxylic acid cycle succinate dehydrogenase (ubiquinone) activity mitochondrial respiratory chain complex II|mitochondrion
YJR092W YJR092W BUD4 hom Verified 0.605896676086963 0.272291683408351 no 1315 0.260237202184438 874 NA FT CELL CYCLE|CELL DIVISION SITE OF POLARIZED GROWTH|CYTOSKELETON Anillin-like protein involved in bud-site selection; required for the axial budding pattern; localizes with septins to the bud neck in mitosis and may constitute an axial landmark for the next round of budding; required for the formation and disassembly of the double septin ring structure, and generally for septin organization; in vivo substrate of Cdc28p/Clb2p cellular bud site selection|axial cellular bud site selection GTP binding cellular bud neck contractile ring
YML084W_d YML084W YML084W hom Dubious 0.60550803996955 0.272420742098664 no 1316 0.244786981371359 863 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YJL122W YJL122W ALB1 hom Verified 0.604536978433335 0.272743345969314 no 1317 0.244459015820226 843 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS NUCLEUS Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit; interacts directly with Arx1p; responsible for Tif6p recycling defects in absence of Rei1p ribosomal large subunit biogenesis molecular_function ribosome|nucleus|cytoplasm
YPL038W YPL038W MET31 hom Verified 0.604013296529696 0.272917401029066 no 1318 0.272579861366691 949 NA FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS Zinc-finger DNA-binding transcription factor; involved in transcriptional regulation of the methionine biosynthetic genes; MET31 has a paralog, MET32, that arose from the whole genome duplication regulation of sulfur amino acid metabolic process|regulation of transcription from RNA polymerase II promoter core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity nucleus|cytoplasm
YER045C YER045C ACA1 hom Verified 0.603524317686831 0.273079971617313 no 1319 0.263316493459327 920 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS ATF/CREB family basic leucine zipper (bZIP) transcription factor; binds as a homodimer to the ATF/CREB consensus sequence TGACGTCA; important for carbon source utilization; target genes include GRE2 and COS8; ACA1 has a paralog, CST6, that arose from the whole genome duplication positive regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus
YLR049C_p YLR049C YLR049C hom Uncharacterized 0.603172198091901 0.27319707038882 no 1320 0.205427304308844 719 NA Putative protein of unknown function biological_process molecular_function cellular_component
YEL003W YEL003W GIM4 hom Verified 0.60123883283023 0.273840461660314 no 1321 0.268185863368053 913 NA FT PROTEIN COMPLEX ORG/BIOGENESIS Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it tubulin complex assembly tubulin binding prefoldin complex|cytoplasm
YBR272C YBR272C HSM3 hom Verified 0.601110849646148 0.273883078724995 no 1322 0.262849491230717 901 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RESPONSE TO DNA DAMAGE NUCLEUS Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); involved in DNA mismatch repair during slow growth; weak similarity to Msh1p; related to human 19S subunit S5b; structural study suggests Hsm3p is a scaffold protein for Rpt1p-Rpt2p complex formation mismatch repair|proteasome regulatory particle assembly molecular_function cytosol|proteasome regulatory particle, base subcomplex|nucleus|cytoplasm
YDR108W YDR108W TRS85 hom Verified 0.599209671770831 0.274516536984334 no 1323 0.312171262094508 1061 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS|PEROXISOME ORGANIZATION GOLGI APPARATUS Subunit of TRAPPIII (transport protein particle), a multimeric guanine nucleotide-exchange factor for Ypt1p, required for membrane expansion during autophagy and the CVT pathway; directs Ypt1p to the PAS; late post-replication meiotic role meiosis|vesicle organization|piecemeal microautophagy of nucleus|ER to Golgi vesicle-mediated transport|peroxisome degradation|macroautophagy|protein localization to pre-autophagosomal structure|CVT pathway molecular_function TRAPP complex|pre-autophagosomal structure
YOL036W_p YOL036W YOL036W hom Uncharacterized 0.599068116514031 0.274563731038203 no 1324 0.275201657753055 920 NA Protein of unknown function; potential Cdc28p substrate; YOL036W has a paralog, YIR016W, that arose from the whole genome duplication biological_process molecular_function cellular_component
YER109C YER109C FLO8 hom Verified 0.598706495340997 0.274684312510275 no 1325 0.255415328218935 847 NA FT TRANSCRIPTION FROM RNA POL II|CARBOHYDRATE METABOLISM NUCLEUS Transcription factor required for flocculation, diploid filamentous growth, and haploid invasive growth; genome reference strain S288C and most laboratory strains have a mutation in this gene biofilm formation|Unknown|positive regulation of starch catabolic process by positive regulation of transcription from RNA polymerase II promoter|positive regulation of invasive growth in response to glucose limitation by positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus|cytoplasm
YKL221W YKL221W MCH2 hom Verified 0.597792874354183 0.274989072915711 no 1326 0.289540799206136 987 NA Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport transport monocarboxylic acid transmembrane transporter activity|transporter activity integral to membrane|membrane
YNL339C YNL339C YRF1-6 hom Verified 0.597232198666537 0.275176182317895 no 1327 0.255530159786667 857 NA FT NUCLEUS Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p telomere maintenance via recombination DNA helicase activity nucleus
YDR276C YDR276C PMP3 hom Verified 0.596919377749475 0.275280604548809 no 1328 0.287988490245848 992 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE Small plasma membrane protein related to a family of plant polypeptides that are overexpressed under high salt concentration or low temperature, not essential for viability, deletion causes hyperpolarization of the plasma membrane potential regulation of membrane potential|cation transport molecular_function plasma membrane
YGR031W YGR031W IMO32 hom Verified 0.596011221848558 0.275583865020458 no 1329 0.268058250973657 932 NA FT MITOCHONDRION Conserved mitochondrial protein of unknown function; processed by both mitochondrial processing peptidase and mitochondrial octapeptidyl aminopeptidase; gene contains the nested antisense gene NAG1 biological_process molecular_function mitochondrion
YIL030C YIL030C SSM4 hom Verified 0.595391438019383 0.275790923688551 no 1330 0.286753350808555 999 NA FT PROTEOLYSIS ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM UBIQUITIN LIGASE COMPLEX Ubiquitin-protein ligase involved in ER-associated protein degradation; located in the ER/nuclear envelope; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation ER-associated protein catabolic process ubiquitin-protein ligase activity nuclear envelope|integral to endoplasmic reticulum membrane|Doa10p ubiquitin ligase complex|integral to membrane|nuclear inner membrane
YKL118W_d YKL118W YKL118W hom Dubious 0.595365903129857 0.27579945607693 no 1331 0.369187778605972 1206 NA FF Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene VPH2 Unknown Unknown Unknown
YDR128W YDR128W MTC5 hom Verified 0.595312934773563 0.275817155669825 no 1332 0.254668691593887 860 NA Subunit of the SEA (Seh1-associated) complex; SEA is a coatomer-related complex that associates dynamically with the vacuole; has N-terminal WD-40 repeats and a C-terminal RING motif; mtc5 is synthetically sick with cdc13-1; relative distribution to vacuolar membrane punctae decreases upon DNA replication stress biological_process molecular_function fungal-type vacuole membrane|Seh1-associated complex|extrinsic to fungal-type vacuolar membrane
YBR015C YBR015C MNN2 hom Verified 0.594377640098876 0.276129780118286 no 1333 0.359507416496048 1220 NA FF|FT CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Alpha-1,2-mannosyltransferase, responsible for addition of the first alpha-1,2-linked mannose to form the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment protein glycosylation alpha-1,2-mannosyltransferase activity Golgi apparatus
YPR064W_d YPR064W YPR064W hom Dubious 0.591423495121034 0.277118350884787 no 1334 0.271673747695066 939 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YMR119W-A_d YMR119W-A YMR119W-A hom Dubious 0.590337234823279 0.277482290437027 no 1335 0.278054788053442 935 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YDR254W YDR254W CHL4 hom Verified 0.589992222257764 0.277597931961307 no 1336 0.275071009786211 896 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME KINETOCHORE Outer kinetochore protein required for chromosome stability; involved in new kinetochore assembly and sister chromatid cohesion; peripheral component of the Ctf19 kinetochore complex that interacts with Ctf19p, Ctf3p, Iml3p and Mif2p; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-N and fission yeast mis15 kinetochore assembly|chromosome segregation|establishment of meiotic sister chromatid cohesion|protein localization to chromosome, centromeric region|maintenance of meiotic sister chromatid cohesion|establishment of mitotic sister chromatid cohesion structural molecule activity condensed nuclear chromosome outer kinetochore
YBR084W YBR084W MIS1 hom Verified 0.589115387796512 0.277891935798885 no 1337 0.257012339407252 898 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM MITOCHONDRION Mitochondrial C1-tetrahydrofolate synthase, involved in interconversion between different oxidation states of tetrahydrofolate (THF); provides activities of formyl-THF synthetase, methenyl-THF cyclohydrolase, and methylene-THF dehydrogenase nucleobase-containing compound metabolic process|folic acid biosynthetic process formate-tetrahydrofolate ligase activity|methylenetetrahydrofolate dehydrogenase (NADP+) activity|methenyltetrahydrofolate cyclohydrolase activity mitochondrion
YEL059W_d YEL059W HHY1 hom Dubious 0.587822810845413 0.278325615663209 no 1338 0.264642924189731 872 NA Dubious open reading frame unlikely to encode a functional protein; mutant is hypersensitive to hygromycin B indicative of defects in vacuolar trafficking Unknown Unknown Unknown
YBL019W YBL019W APN2 hom Verified 0.587298947742097 0.2785014738587 no 1339 0.25491316020806 848 NA FT RESPONSE TO DNA DAMAGE NUCLEUS Class II abasic (AP) endonuclease involved in repair of DNA damage; homolog of human HAP1 and E. coli exoIII base-excision repair DNA-(apurinic or apyrimidinic site) lyase activity|double-stranded DNA specific 3'-5' exodeoxyribonuclease activity|phosphoric diester hydrolase activity nucleus
YNL046W_p YNL046W YNL046W hom Uncharacterized 0.587091546343903 0.278571112414309 no 1340 0.263482745992291 897 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Putative protein of unknown function; expression depends on Swi5p; GFP-fusion protein localizes to the endoplasmic reticulum; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) biological_process molecular_function endoplasmic reticulum
YHR185C YHR185C PFS1 hom Verified 0.58683848281376 0.278656094294994 no 1341 0.288080202148506 994 NA FT CELL WALL ORG/BIOGENESIS NUCLEUS|CYTOSKELETON Sporulation protein required for prospore membrane formation at selected spindle poles, ensures functionality of all four spindle pole bodies during meiosis II; not required for meiotic recombination or meiotic chromosome segregation ascospore wall assembly molecular_function cellular_component
YJL046W YJL046W AIM22 hom Verified 0.586172348198772 0.278879850911609 no 1342 0.277776177301372 950 NA FT MITOCHONDRION Putative lipoate-protein ligase, required along with Lip2 and Lip5 for lipoylation of Lat1p and Kgd2p; similar to E. coli LplA; null mutant displays reduced frequency of mitochondrial genome loss protein lipoylation lipoate-protein ligase activity mitochondrion
YJL148W YJL148W RPA34 hom Verified 0.585387545998978 0.279143580446243 no 1343 0.215377836517491 715 NA FT NUCLEUS RNA polymerase I subunit A34.5 transcription elongation from RNA polymerase I promoter|transcription of nuclear large rRNA transcript from RNA polymerase I promoter molecular_function DNA-directed RNA polymerase I complex|nucleolus|nucleus
YAL004W_d YAL004W YAL004W hom Dubious 0.584357551459496 0.279489889733064 no 1344 0.298487735735266 1008 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene SSA1/YAL005C Unknown Unknown Unknown
YBR024W YBR024W SCO2 hom Verified 0.583822693554323 0.279669804268886 no 1345 0.274711141040715 920 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION Protein anchored to mitochondrial inner membrane; may have a redundant function with Sco1p in delivery of copper to cytochrome c oxidase; interacts with Cox2p; SCO2 has a paralog, SCO1, that arose from the whole genome duplication copper ion transport thioredoxin peroxidase activity mitochondrial envelope|mitochondrion
YPR106W YPR106W ISR1 hom Verified 0.583239241650298 0.279866128843792 no 1346 0.270398276754707 905 NA FT PROTEIN PHOSPHORYLATION Predicted protein kinase, overexpression causes sensitivity to staurosporine, which is a potent inhibitor of protein kinase C biological_process protein kinase activity cellular_component
YMR062C YMR062C ARG7 hom Verified 0.582975742659036 0.279954815002493 no 1347 0.326334585043289 1107 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|CELL WALL ORG/BIOGENESIS MITOCHONDRION Mitochondrial ornithine acetyltransferase, catalyzes the fifth step in arginine biosynthesis; also possesses acetylglutamate synthase activity, regenerates acetylglutamate while forming ornithine fungal-type cell wall organization|ornithine biosynthetic process|arginine biosynthetic process acetyl-CoA:L-glutamate N-acetyltransferase activity|glutamate N-acetyltransferase activity mitochondrion|mitochondrial matrix
YDR405W YDR405W MRP20 hom Verified 0.581035162671131 0.280608377628255 no 1348 0.266355296022408 933 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YNR070W_p YNR070W PDR18 hom Uncharacterized 0.580467569203437 0.280799675321862 no 1349 0.25878537334255 914 NA FT NUCLEOTIDE METABOLISM MITOCHONDRION Putative transporter of the ATP-binding cassette (ABC) family, implicated in pleiotropic drug resistance; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies transport ATPase activity, coupled to transmembrane movement of substances mitochondrion|integral to membrane|membrane
YHR209W YHR209W CRG1 hom Verified 0.578382215070388 0.281503049290477 no 1350 0.282301967106675 969 NA S-AdoMet-dependent methyltransferase involved in lipid homeostasis; mediates resistance to a drug cantharidin lipid homeostasis mRNA binding|S-adenosylmethionine-dependent methyltransferase activity|methyltransferase activity cellular_component
YDR104C YDR104C SPO71 hom Verified 0.577485641965239 0.281805717584427 no 1351 0.248386843439053 825 NA FT CELL WALL ORG/BIOGENESIS Meiosis-specific protein of unknown function, required for spore wall formation during sporulation, in particular for the proper size of the prospore membrane (PSM); interacts with SPO1; dispensable for both nuclear divisions during meiosis; contains two PH domains ascospore wall assembly molecular_function ascospore wall
YOR289W_p YOR289W YOR289W hom Uncharacterized 0.577457914209764 0.281815080517031 no 1352 0.269670992935723 898 NA FT NUCLEUS Putative protein of unknown function; transcription induced by the unfolded protein response; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus biological_process molecular_function nucleus|cytoplasm
YJL151C YJL151C SNA3 hom Verified 0.576779437281015 0.282044231006377 no 1353 0.275586242544932 946 NA FT VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM Protein involved in efficient MVB sorting of proteins to the vacuole; may function as an RSP5 adapter protein for MVB cargos; integral membrane protein localized to vacuolar intralumenal vesicles cellular protein catabolic process|endosome transport via multivesicular body sorting pathway ubiquitin protein ligase binding fungal-type vacuole lumen|integral to membrane
YKL039W YKL039W PTM1 hom Verified 0.576467735349944 0.282149536065831 no 1354 0.270813437185633 927 NA FT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Protein of unknown function; copurifies with late Golgi vesicles containing the v-SNARE Tlg2p; PTM1 has a paralog, YHL017W, that arose from the whole genome duplication biological_process molecular_function integral to membrane
YLR199C YLR199C PBA1 hom Verified 0.575485120960391 0.282481625323442 no 1355 0.247707004422273 839 NA FT PROTEIN COMPLEX ORG/BIOGENESIS Protein involved in 20S proteasome assembly; forms a heterodimer with Add66p that binds to proteasome precursors; similar to human PAC1 constituent of the PAC1-PAC2 complex involved in proteasome assembly proteasome assembly molecular_function cytoplasm
YLR421C YLR421C RPN13 hom Verified 0.575382705836396 0.282516248862457 no 1356 0.291373859830668 1016 NA FT PROTEOLYSIS NUCLEUS Subunit of the 19S regulatory particle of the 26S proteasome lid; acts as a ubiquitin receptor for the proteasome; null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; protein abundance increases in response to DNA replication stress ubiquitin-dependent protein catabolic process ubiquitin binding proteasome storage granule|proteasome regulatory particle, lid subcomplex
YLR452C YLR452C SST2 hom Verified 0.574760791690118 0.282726543535607 no 1357 0.277840226686336 947 NA FT SIGNALING PLASMA MEMBRANE GTPase-activating protein for Gpa1p, regulates desensitization to alpha factor pheromone; also required to prevent receptor-independent signaling of the mating pathway; member of the RGS (regulator of G-protein signaling) family adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion|signal transduction GTPase activator activity plasma membrane
YFR044C YFR044C DUG1 hom Verified 0.574458073046079 0.282828932329394 no 1358 0.28695395980655 981 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|PROTEOLYSIS MITOCHONDRION Cys-Gly metallo-di-peptidase; forms a complex with Dug2p and Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p) glutathione catabolic process metallodipeptidase activity|omega peptidase activity mitochondrion|ribosome|cytoplasm
YLR251W YLR251W SYM1 hom Verified 0.573201191677306 0.28325423880445 no 1359 0.272655521090118 917 NA FT MITOCHONDRION Protein required for ethanol metabolism; induced by heat shock and localized to the inner mitochondrial membrane; homologous to mammalian peroxisomal membrane protein Mpv17 ethanol metabolic process molecular_function mitochondrion|integral to membrane|mitochondrial inner membrane
YKR100C YKR100C SKG1 hom Verified 0.573047196751713 0.283306369057152 no 1360 0.291988488277739 1005 NA FT CELL WALL ORG/BIOGENESIS SITE OF POLARIZED GROWTH|PLASMA MEMBRANE Transmembrane protein with a role in cell wall polymer composition; localizes on the inner surface of the plasma membrane at the bud and in the daughter cell fungal-type cell wall organization molecular_function incipient cellular bud site|cellular bud|cellular bud tip
YLR384C YLR384C IKI3 hom Verified 0.572384327451963 0.283530815612617 no 1361 0.268288989001369 913 NA FT PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|RNA PROCESSING NUCLEUS Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator; homolog of human IKAP, mutations in which cause familial dysautonomia (FD) regulation of transcription from RNA polymerase II promoter|tRNA wobble uridine modification molecular_function Elongator holoenzyme complex|nucleus|cytoplasm
YEL046C YEL046C GLY1 hom Verified 0.571994440965074 0.283662870381766 no 1362 0.318341690589543 1056 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Threonine aldolase, catalyzes the cleavage of L-allo-threonine and L-threonine to glycine; involved in glycine biosynthesis threonine catabolic process|glycine biosynthetic process threonine aldolase activity|L-allo-threonine aldolase activity cytosol
YCR091W YCR091W KIN82 hom Verified 0.57189368637798 0.283697000805898 no 1363 0.258313730928736 920 NA FT MEMBRANE ORGANIZATION|PROTEIN PHOSPHORYLATION Putative serine/threonine protein kinase implicated in the regulation of phospholipid asymmetry through the activation of phospholipid translocases (flippases) Lem3p-Dnf1p/Dnf2p; similar to Fpk1p phospholipid translocation|protein phosphorylation|response to pheromone protein kinase activity cellular_component
YKL185W YKL185W ASH1 hom Verified 0.570711849917014 0.284097492421572 no 1364 0.247878512313023 856 NA FT CHROMATIN ORGANIZATION NUCLEUS|CHROMOSOME Zinc-finger inhibitor of HO transcription; mRNA is localized and translated in the distal tip of anaphase cells, resulting in accumulation of Ash1p in daughter cell nuclei and inhibition of HO expression; potential Cdc28p substrate Unknown RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|core promoter proximal region sequence-specific DNA binding Rpd3L-Expanded complex|nucleus|cellular bud|Rpd3L complex
YCR066W YCR066W RAD18 hom Verified 0.569581436331778 0.284480811092768 no 1365 0.305643969650045 1095 NA FF|FT RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME E3 ubiquitin ligase; forms heterodimer with Rad6p to monoubiquitinate PCNA-K164; heterodimer binds single-stranded DNA and has single-stranded DNA dependent ATPase activity; required for postreplication repair; SUMO-targeted ubiquitin ligase (STUbl) that contains a SUMO-interacting motif (SIM) which stimulates its ubiquitin ligase activity towards the sumoylated form of PCNA protein monoubiquitination|error-free translesion synthesis|error-free postreplication DNA repair|error-prone translesion synthesis ubiquitin-protein ligase activity|single-stranded DNA-dependent ATPase activity|single-stranded DNA binding nuclear chromatin|nucleus
YDR401W_d YDR401W YDR401W hom Dubious 0.569321339093177 0.284569043963632 no 1366 0.29962748743988 1024 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YPL030W YPL030W TRM44 hom Verified 0.568465819856612 0.284859354182834 no 1367 0.269123827521787 914 NA FT RNA PROCESSING tRNA(Ser) Um(44) 2'-O-methyltransferase; involved in maintaining levels of the tRNA-Ser species tS(CGA) and tS(UGA); conserved among metazoans and fungi but there does not appear to be a homolog in plants; TRM44 is a non-essential gene tRNA methylation tRNA (uracil) methyltransferase activity cytoplasm
YPR063C_p YPR063C YPR063C hom Uncharacterized 0.567877613073896 0.285059037054157 no 1368 0.291990283470362 990 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM ER-localized protein of unknown function biological_process molecular_function endoplasmic reticulum
YNL073W YNL073W MSK1 hom Verified 0.567171327731727 0.28529889305905 no 1369 0.291696505320234 996 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION|RNA LOCALIZATION MITOCHONDRION Mitochondrial lysine-tRNA synthetase, required for import of both aminoacylated and deacylated forms of tRNA(Lys) into mitochondria and for aminoacylation of mitochondrially encoded tRNA(Lys) tRNA import into mitochondrion|lysyl-tRNA aminoacylation|mitochondrial lysyl-tRNA aminoacylation|mitochondrial translation lysine-tRNA ligase activity mitochondrion
YDR033W YDR033W MRH1 hom Verified 0.567046082232646 0.28534143673121 no 1370 0.28564077308809 972 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION|PLASMA MEMBRANE Protein that localizes primarily to the plasma membrane; also found at the nuclear envelope; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; MRH1 has a paralog, YRO2, that arose from the whole genome duplication biological_process molecular_function mitochondrion|integral to membrane|plasma membrane
YJR150C YJR150C DAN1 hom Verified 0.566143941342381 0.285647967211147 no 1371 0.251675986947187 862 NA Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth sterol transport molecular_function fungal-type cell wall
YER034W YER034W YER034W hom Verified 0.565875309308567 0.285739273581215 no 1372 0.29704312985541 1013 NA FT NUCLEUS Protein of unknown function; non-essential gene; expression induced upon calcium shortage; protein abundance increases in response to DNA replication stress biological_process molecular_function nucleus|cytoplasm
YAL056W YAL056W GPB2 hom Verified 0.565839643720895 0.285751397138198 no 1373 0.281575495471971 979 NA FT TRANSCRIPTION FROM RNA POL II|SIGNALING MITOCHONDRION|PLASMA MEMBRANE Multistep regulator of cAMP-PKA signaling; inhibits PKA downstream of Gpa2p and Cyr1p, thereby increasing cAMP dependency; inhibits Ras activity through direct interactions with Ira1p/2p; regulated by G-alpha protein Gpa2p; GPB2 has a paralog, GPB1, that arose from the whole genome duplication signal transduction|glucose mediated signaling pathway|pseudohyphal growth|ascospore formation|negative regulation of Ras protein signal transduction|invasive growth in response to glucose limitation|positive regulation of transcription from RNA polymerase II promoter cAMP-dependent protein kinase inhibitor activity|signal transducer activity|GTPase activating protein binding mitochondrion|plasma membrane|cytoplasm
YKL094W YKL094W YJU3 hom Verified 0.564680511649221 0.286145546032001 no 1374 0.283588382767714 992 NA FT LIPID METABOLISM ENDOPLASMIC RETICULUM|MITOCHONDRION Monoglyceride lipase (MGL), functional ortholog of mammalian MGL, localizes to lipid particles and membranes, also member of the eukaryotic serine hydrolase family triglyceride metabolic process serine hydrolase activity|acylglycerol lipase activity mitochondrial outer membrane|lipid particle|plasma membrane|membrane|cytoplasm
YDR028C YDR028C REG1 hom Verified 0.564058378348713 0.28635720141494 no 1375 0.372510103069442 1236 NA FF|FT TRANSCRIPTION FROM RNA POL II|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS|GEN. OF PRECURSOR METABOLITES AND ENERGY NUCLEUS Regulatory subunit of type 1 protein phosphatase Glc7p; involved in negative regulation of glucose-repressible genes; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p cellular response to glucose starvation|vacuolar protein catabolic process|glycogen metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of carbohydrate metabolic process protein phosphatase type 1 regulator activity protein phosphatase type 1 complex|cytoplasm
YDR268W YDR268W MSW1 hom Verified 0.563771665999772 0.286454768562413 no 1376 0.301964306002305 1019 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial tryptophanyl-tRNA synthetase mitochondrial tryptophanyl-tRNA aminoacylation tryptophan-tRNA ligase activity mitochondrion
YHR050W-A_p YHR050W-A YHR050W-A hom Uncharacterized 0.563012854350061 0.286713065442596 no 1377 0.288426357390672 985 NA Protein of unknown function; identified by expression profiling and mass spectrometry biological_process molecular_function cellular_component
YNR029C_p YNR029C YNR029C hom Uncharacterized 0.562619455615301 0.286847020471713 no 1378 0.26628453634104 942 NA Putative protein of unknown function, deletion confers reduced fitness in saline biological_process molecular_function cytoplasm
YBL063W YBL063W KIP1 hom Verified 0.56223496804649 0.286977969838566 no 1379 0.266133986776164 889 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION CYTOSKELETON Kinesin-related motor protein required for mitotic spindle assembly, chromosome segregation, and 2 micron plasmid partitioning; functionally redundant with Cin8p for chromosomal but not plasmid functions mitotic anaphase B|microtubule depolymerization|spindle pole body separation|plasmid partitioning|mitotic sister chromatid segregation microtubule motor activity|structural constituent of cytoskeleton spindle microtubule|kinesin complex|spindle pole body
YDL210W YDL210W UGA4 hom Verified 0.561751403271375 0.287142703264493 no 1380 0.261009650562818 877 NA Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane gamma-aminobutyric acid transport|putrescine transport|transmembrane transport putrescine transmembrane transporter activity|gamma-aminobutyric acid:hydrogen symporter activity fungal-type vacuole membrane|integral to membrane
YHR073W YHR073W OSH3 hom Verified 0.560940926397757 0.287418904439997 no 1381 0.280609730298376 978 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION ENDOPLASMIC RETICULUM Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability karyogamy involved in conjugation with cellular fusion|endocytosis|exocytosis|positive regulation of phosphatase activity|maintenance of cell polarity|pseudohyphal growth|sterol transport|invasive growth in response to glucose limitation lipid binding|oxysterol binding|1-phosphatidylinositol binding|sterol transporter activity cortical endoplasmic reticulum|cytoplasm
YMR122C_d YMR122C YMR122C hom Dubious 0.560909344969421 0.28742966956992 no 1382 0.314891670445346 1065 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YGL072C_d YGL072C YGL072C hom Dubious 0.560484750469087 0.287574419186643 no 1383 0.316673184271598 1079 NA FF Dubious open reading frame unlikely to encode a protein; partially overlaps the verified gene HSF1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2 Unknown Unknown Unknown
YLR042C_p YLR042C YLR042C hom Uncharacterized 0.559757611306014 0.287822390102188 no 1384 0.271072176721802 920 NA Protein of unknown function; localizes to the cytoplasm; YLL042C is not an essential gene biological_process molecular_function fungal-type cell wall
YLR046C_p YLR046C YLR046C hom Uncharacterized 0.558578785385563 0.288224610877201 no 1385 0.272541365116806 940 NA Putative membrane protein; member of the fungal lipid-translocating exporter (LTE) family of proteins; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance biological_process molecular_function integral to membrane
YJL096W YJL096W MRPL49 hom Verified 0.558298579582422 0.288320257360408 no 1386 0.308100447702489 1032 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YJL141C YJL141C YAK1 hom Verified 0.558130236131701 0.288377727531265 no 1387 0.277788908315983 955 NA FT PROTEIN PHOSPHORYLATION NUCLEUS Serine-threonine protein kinase; component of a glucose-sensing system that inhibits growth in response to glucose availability; upon nutrient deprivation Yak1p phosphorylates Pop2p to regulate mRNA deadenylation, the co-repressor Crf1p to inhibit transcription of ribosomal genes, and the stress-responsive transcription factors Hsf1p and Msn2p; nuclear localization negatively regulated by the Ras/PKA signaling pathway in the presence of glucose protein phosphorylation protein serine/threonine kinase activity|protein tyrosine kinase activity|protein kinase activity nucleus|cytoplasm
YMR140W YMR140W SIP5 hom Verified 0.558124918003407 0.288379543156132 no 1388 0.272571249802239 931 NA FT RESPONSE TO NUTRIENT LEVELS Protein of unknown function; interacts with both the Reg1p/Glc7p phosphatase and the Snf1p kinase; forms cytoplasmic foci upon DNA replication stress cellular response to glucose starvation molecular_function cytoplasm
YGL185C_p YGL185C YGL185C hom Uncharacterized 0.557509097033583 0.288589822706325 no 1389 0.328054488514532 1110 NA FT OXIDATION-REDUCTION PROCESS Putative protein with sequence similarity to hydroxyacid dehydrogenases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm metabolic process oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor cytoplasm
YNR037C YNR037C RSM19 hom Verified 0.555165901118405 0.289390595020453 no 1390 0.308234166048329 1055 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S19 ribosomal protein mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial small ribosomal subunit
YNL035C YNL035C YNL035C hom Verified 0.554862207543658 0.289494456738386 no 1391 0.262993594866178 904 NA FT NUCLEUS Protein of unknown function; contains WD-40 domains; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YNL035C is not an essential gene; protein abundance increases in response to DNA replication stress biological_process molecular_function nucleus
YJL047C-A_p YJL047C-A YJL047C-A hom Uncharacterized 0.55348458158454 0.289965817766108 no 1392 0.284925588340237 946 NA Putative protein of unknown function biological_process molecular_function cellular_component
YDR024W_d YDR024W FYV1 hom Dubious 0.553396088370811 0.289996108420603 no 1393 0.306670759578599 1057 NA Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; mutation decreases survival upon exposure to K1 killer toxin Unknown Unknown Unknown
YLR389C YLR389C STE23 hom Verified 0.552788879831199 0.290203991977025 no 1394 0.272319055011274 935 NA FT PROTEOLYSIS Metalloprotease involved, with homolog Axl1p, in N-terminal processing of pro-a-factor to the mature form; expressed in both haploids and diploids; member of the insulin-degrading enzyme family peptide pheromone maturation metallopeptidase activity|metalloendopeptidase activity extrinsic to membrane
YHR115C YHR115C DMA1 hom Verified 0.55242301241641 0.290329283826308 no 1395 0.298114275084597 1039 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION Ubiquitin-protein ligase (E3); controls septin dynamics and the spindle position checkpoint (SPOC) along with functionally redundant ligase Dma2p by regulating the recruitment of Elm1p to the bud neck; regulates levels of the translation initiation factor eIF2 subunit Gcd11p, as well as abundance, localization, and ubiquitination of Cdk inhibitory kinase Swe1p; ubiquitinates cyclin Pcl1p; ortholog of human RNF8 protein, similar to human Chfr; contains FHA and RING finger establishment of mitotic spindle orientation|protein autoubiquitination|septin ring assembly|mitotic cell cycle spindle assembly checkpoint ubiquitin-protein ligase activity cytoplasm
YML120C YML120C NDI1 hom Verified 0.55175351994746 0.290558618098539 no 1396 0.268391626253202 920 NA FT OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION NADH:ubiquinone oxidoreductase; transfers electrons from NADH to ubiquinone in the respiratory chain but does not pump protons, in contrast to the higher eukaryotic multisubunit respiratory complex I; phosphorylated; involved in Mn and H2O2 induced apoptosis; upon apoptotic stress, Ndip is activated in the mitochondria by N-terminal cleavage, and the truncated protein translocates to the cytoplasm to induce apoptosis; homolog of human AMID mitochondrial electron transport, NADH to ubiquinone|NADH oxidation|chronological cell aging|positive regulation of apoptotic process NADH dehydrogenase (ubiquinone) activity mitochondrion|mitochondrial matrix
YCL044C YCL044C MGR1 hom Verified 0.550774375305614 0.290894176107711 no 1397 0.281268910218953 952 NA FT PROTEOLYSIS MITOCHONDRION Subunit of the mitochondrial (mt) i-AAA protease supercomplex, which degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr3p that binds to substrates to facilitate proteolysis; required for growth of cells lacking mtDNA misfolded or incompletely synthesized protein catabolic process misfolded protein binding mitochondrion|i-AAA complex
YNL291C YNL291C MID1 hom Verified 0.550320858742629 0.29104965996475 no 1398 0.269799731153655 896 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS ENDOPLASMIC RETICULUM|PLASMA MEMBRANE N-glycosylated integral membrane protein of the ER membrane and plasma membrane, functions as a stretch-activated Ca2+-permeable cation channel required for Ca2+ influx stimulated by pheromone; interacts with Cch1p; forms an oligomer calcium ion transport stretch-activated, cation-selective, calcium channel activity|calcium channel activity endoplasmic reticulum|plasma membrane
YOR253W YOR253W NAT5 hom Verified 0.550277627489405 0.291064483416824 no 1399 0.292170655708919 1005 NA FT RIBOSOME Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing N-terminal protein amino acid acetylation peptide alpha-N-acetyltransferase activity NatA complex|cytosolic ribosome
YJR080C YJR080C AIM24 hom Verified 0.549927891272295 0.29118441652377 no 1400 0.254514176483746 886 NA FT MITOCHONDRION Protein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays reduced respiratory growth and elevated frequency of mitochondrial genome loss biological_process molecular_function mitochondrion
YPL214C YPL214C THI6 hom Verified 0.549508333329334 0.291328323645056 no 1401 0.258697499174131 887 NA Bifunctional enzyme with thiamine-phosphate pyrophosphorylase and 4-methyl-5-beta-hydroxyethylthiazole kinase activities, required for thiamine biosynthesis; GFP-fusion protein localizes to the cytoplasm in a punctate pattern thiamine biosynthetic process hydroxyethylthiazole kinase activity|thiamine-phosphate diphosphorylase activity cytosol|cytoplasm
YLR237W YLR237W THI7 hom Verified 0.547041715510562 0.292175036586771 no 1402 0.311560670936048 1037 NA FT PLASMA MEMBRANE Plasma membrane transporter responsible for the uptake of thiamine, member of the major facilitator superfamily of transporters; mutation of human ortholog causes thiamine-responsive megaloblastic anemia thiamine transport thiamine transmembrane transporter activity integral to membrane|plasma membrane
YDL117W YDL117W CYK3 hom Verified 0.546974733507263 0.292198045379688 no 1403 0.286910124405188 975 NA FT CELL CYCLE|CELL DIVISION SITE OF POLARIZED GROWTH|CYTOSKELETON SH3-domain protein located in the bud neck and cytokinetic actin ring; relocalizes from bud neck to nucleus upon DNA replication stress; activates the chitin synthase activity of Chs2p during cytokinesis; suppressor of growth and cytokinesis defects of chs2 phospho-mutants barrier septum assembly involved in cell cycle cytokinesis|cytokinesis molecular_function cellular bud neck contractile ring|cellular bud neck|cytoplasm
YKL170W YKL170W MRPL38 hom Verified 0.546136424943198 0.292486081587342 no 1404 0.304833247985187 1048 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL34 and YmL38) on two-dimensional SDS gels; protein abundance increases in response to DNA replication stress mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YCL055W YCL055W KAR4 hom Verified 0.545976849469145 0.292540925409148 no 1405 0.270514505067231 958 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE NUCLEUS Transcription factor required for gene regulation in response to pheromones; also required during meiosis; exists in two forms, a slower-migrating form more abundant during vegetative growth and a faster-migrating form induced by pheromone karyogamy involved in conjugation with cellular fusion|meiosis|negative regulation of transcription from RNA polymerase II promoter by pheromones|positive regulation of transcription from RNA polymerase II promoter by pheromones|G1 phase of mitotic cell cycle sequence-specific DNA binding transcription factor activity nucleus|cytoplasm
YBL037W YBL037W APL3 hom Verified 0.545238370361441 0.292794792389448 no 1406 0.289118325439902 967 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|PLASMA MEMBRANE Alpha-adaptin, large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport vesicle-mediated transport molecular_function AP-2 adaptor complex
YPL154C YPL154C PEP4 hom Verified 0.54455010061446 0.293031490947395 no 1407 0.301989077777912 1025 NA FT MEMBRANE ORGANIZATION|PROTEOLYSIS|RESPONSE TO NUTRIENT LEVELS MITOCHONDRION Vacuolar aspartyl protease (proteinase A), required for the posttranslational precursor maturation of vacuolar proteinases; important for protein turnover after oxidative damage; synthesized as a zymogen, self-activates microautophagy|proteolysis involved in cellular protein catabolic process|cellular response to starvation peptidase activity fungal-type vacuole lumen|mitochondrion|fungal-type vacuole
YHL033C YHL033C RPL8A hom Verified 0.544532149294324 0.293037665661643 no 1408 0.2750515482767 933 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Ribosomal 60S subunit protein L8A; mutation results in decreased amounts of free 60S subunits; homologous to mammalian ribosomal protein L7A, no bacterial homolog; RPL8A has a paralog, RPL8B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YGR201C_p YGR201C YGR201C hom Uncharacterized 0.544485812585449 0.293053604374913 no 1409 0.274474820619015 932 NA Putative protein of unknown function biological_process molecular_function cellular_component
YJL136C YJL136C RPS21B hom Verified 0.544310221900109 0.293114006996052 no 1410 0.30283609152785 999 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21B has a paralog, RPS21A, that arose from the whole genome duplication endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|cytoplasmic translation|endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) structural constituent of ribosome cytosolic small ribosomal subunit
YGL094C YGL094C PAN2 hom Verified 0.544255877136828 0.293132702586756 no 1411 0.304950130452183 1083 NA FT RNA PROCESSING|RESPONSE TO DNA DAMAGE|PROTEOLYSIS Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes mRNA 3'-end processing|postreplication repair|mRNA processing poly(A)-specific ribonuclease activity PAN complex|cytoplasm
YOL108C YOL108C INO4 hom Verified 0.543881711832711 0.293261437290358 no 1412 0.296811173787262 1033 NA FT TRANSCRIPTION FROM RNA POL II|LIPID METABOLISM NUCLEUS Transcription factor required for derepression of inositol-choline-regulated genes involved in phospholipid synthesis; forms a complex, with Ino2p, that binds the inositol-choline-responsive element through a basic helix-loop-helix domain phospholipid biosynthetic process|positive regulation of transcription from RNA polymerase II promoter DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus
YOL047C_p YOL047C YOL047C hom Uncharacterized 0.54324483017425 0.293480622000341 no 1413 0.285155092583773 937 NA Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern biological_process molecular_function integral to membrane|cytoplasm
YLR285C-A_p YLR285C-A YLR285C-A hom Uncharacterized 0.543151033014199 0.293512908980212 no 1414 0.280772722465178 940 NA Putative protein of unknown function; identified by fungal homology and RT-PCR biological_process molecular_function cellular_component
YHR031C YHR031C RRM3 hom Verified 0.541660757824084 0.294026113991268 no 1415 0.311589989140214 1067 NA FT RESPONSE TO DNA DAMAGE|MITOCHONDRION ORGANIZATION NUCLEUS|CHROMOSOME DNA helicase involved in rDNA replication and Ty1 transposition; relieves replication fork pauses at telomeric regions; structurally and functionally related to Pif1p mitochondrial genome maintenance|replication fork progression beyond termination site|DNA replication ATP-dependent DNA helicase activity|DNA helicase activity nuclear telomeric heterochromatin|replication fork
YOR284W YOR284W HUA2 hom Verified 0.541288001238553 0.294154544739111 no 1416 0.291614245117175 980 NA Cytoplasmic protein of unknown function; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin patch assembly biological_process molecular_function cytoplasm
YLR183C YLR183C TOS4 hom Verified 0.53866991063011 0.29505731958634 no 1417 0.296084732563452 1017 NA FT RESPONSE TO DNA DAMAGE NUCLEUS|MITOCHONDRION|CHROMOSOME Putative transcription factor, contains Forkhead Associated domain; found associated with chromatin; target of SBF transcription factor; expression is periodic and peaks in G1; relative distribution to the nucleus increases upon DNA replication stress; TOS4 has a paralog, PLM2, that arose from the whole genome duplication response to DNA damage stimulus chromatin binding nuclear chromatin|Rpd3L-Expanded complex|mitochondrion|nucleus|cytoplasm
YMR130W_p YMR130W YMR130W hom Uncharacterized 0.537850449437713 0.295340149718598 no 1418 0.257619404584856 882 NA Putative protein of unknown function; YMR130W is not an essential gene biological_process molecular_function cellular_component
YHR138C YHR138C YHR138C hom Verified 0.537429202908276 0.295485587941721 no 1419 0.297074433899943 994 NA FT MEMBRANE ORGANIZATION Protein of unknown function; similar to Pbi2p; double null mutant lacking Pbi2p and Yhr138cp exhibits highly fragmented vacuoles; protein abundance increases in response to DNA replication stress vacuole fusion, non-autophagic endopeptidase inhibitor activity cellular_component
YMR143W YMR143W RPS16A hom Verified 0.537237859439028 0.29555166145008 no 1420 0.289857282398179 964 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S16 and bacterial S9; RPS16A has a paralog, RPS16B, that arose from the whole genome duplication cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) structural constituent of ribosome cytosolic small ribosomal subunit|90S preribosome
YOR189W YOR189W IES4 hom Verified 0.53591695828634 0.296007971827978 no 1421 0.293392926446708 1004 NA FT RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME Component of the INO80 chromatiin remodeling complex and target of the Mec1p/Tel1p DNA damage signaling pathway; proposed to link chromatin remodeling to replication checkpoint responses response to DNA damage stimulus molecular_function nucleus|Ino80 complex
YBR221W-A_p YBR221W-A YBR221W-A hom Uncharacterized 0.535816287242861 0.296042762285979 no 1422 0.291574293900477 972 NA Putative protein of unknown function; identified by expression profiling and mass spectrometry biological_process molecular_function cellular_component
YBR061C YBR061C TRM7 hom Verified 0.534610830264061 0.296459496505946 no 1423 0.294245020100975 1010 NA FT RNA PROCESSING|TRANSLATION 2'-O-ribose methyltransferase; methylates the 2'-O-ribose of tRNA-Phe, tRNA-Trp, and tRNA-Leu at positions C32 and N34 of the tRNA anticodon loop; crucial biological role likely modification of tRNA-Phe; interacts with Trm732p and Rtt10p in 2'-O-methylation of C32 and N34 substrate tRNAs, respectively cytoplasmic translation|tRNA methylation tRNA methyltransferase activity cytoplasm
YLR139C YLR139C SLS1 hom Verified 0.534322490881628 0.296559217114002 no 1424 0.318690121540145 1085 NA FT TRANSLATION|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Mitochondrial membrane protein that coordinates expression of mitochondrially-encoded genes; may facilitate delivery of mRNA to membrane-bound translation machinery aerobic respiration|mitochondrial translation molecular_function mitochondrial nucleoid|mitochondrion|integral to membrane|mitochondrial inner membrane
YOR006C YOR006C TSR3 hom Verified 0.53430525190633 0.296565179606728 no 1425 0.324815054058345 1095 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Protein required for 20S pre-rRNA processing; involved in processing of the 20S pre-rRNA at site D to generate mature 18S rRNA; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; relative distribution to the nucleus increases upon DNA replication stress maturation of SSU-rRNA molecular_function nucleus|cytoplasm
YBR170C YBR170C NPL4 hom Verified 0.534139238795828 0.296622601837638 no 1426 0.298864901689484 999 NA FT PROTEIN LOCALIZATION|RNA LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM UBIQUITIN LIGASE COMPLEX Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase; assists Cdc48p in the dislocation of misfolded, polyubiquitinated ERAD substrates that are subsequently delivered to the proteasome for degradation; also involved in the regulated destruction of resident ER membrane proteins, such as HMG-CoA reductase (Hmg1/2p) and cytoplasmic proteins (Fbp1p); role in mobilizing membrane bound transcription factors by regulated ubiquitin/proteasome-dependent processing (RUP) retrograde protein transport, ER to cytosol|proteasomal ubiquitin-dependent protein catabolic process|mitochondria-associated protein catabolic process|mitotic spindle disassembly|ER-associated protein catabolic process|ER-associated misfolded protein catabolic process|Unknown|cytoplasm-associated proteasomal ubiquitin-dependent protein catabolic process molecular_function Doa10p ubiquitin ligase complex|integral to membrane|Cdc48p-Npl4p-Ufd1p AAA ATPase complex|Cdc48p-Npl4p-Vms1p AAA ATPase complex|nuclear outer membrane-endoplasmic reticulum membrane network
YLR203C YLR203C MSS51 hom Verified 0.533501301337778 0.296843305225727 no 1427 0.28078074189719 916 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Specific translational activator for the mitochondrial COX1 mRNA; loosely associated with the matrix face of the mitochondrial inner membrane; influences both COX1 mRNA translation and Cox1p assembly into cytochrome c oxidase; binds to heme B, which may be a mechanism for sensing oxygen levels in order to regulate cytochrome c oxidase biogenesis mitochondrial respiratory chain complex IV biogenesis|positive regulation of mitochondrial translation translation regulator activity extrinsic to mitochondrial inner membrane|mitochondrion
YDR287W YDR287W INM2 hom Verified 0.533015878524865 0.297011294374766 no 1428 0.30307983470494 1054 NA FT LIPID METABOLISM|CARBOHYDRATE METABOLISM Inositol monophosphatase, involved in biosynthesis of inositol; enzymatic activity requires magnesium ions and is inhibited by lithium and sodium ions; inm1 inm2 double mutant lacks inositol auxotrophy inositol phosphate dephosphorylation inositol monophosphate 1-phosphatase activity cellular_component
YLR403W YLR403W SFP1 hom Verified 0.532841989655626 0.297071482269873 no 1429 0.286072439613083 993 NA FT TRANSCRIPTION FROM RNA POL II|RIBOSOME BIOGENESIS NUCLEUS Regulates transcription of ribosomal protein and biogenesis genes; regulates response to nutrients and stress, G2/M transitions during mitotic cell cycle and DNA-damage response, and modulates cell size; regulated by TORC1 and Mrs6p; sequence of zinc finger, ChIP localization data, and protein-binding microarray (PBM) data, and computational analyses suggest it binds DNA directly at highly active RP genes and indirectly through Rap1p at others; can form the [ISP+] prion positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter|regulation of cell size|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II transcription factor binding transcription factor activity nucleus|cytoplasm
YOL051W YOL051W GAL11 hom Verified 0.53203425813887 0.297351134275033 no 1430 0.357064639166897 1194 NA FF|FT TRANSCRIPTION FROM RNA POL II NUCLEUS RNA POL II, HOLOENZYME Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; affects transcription by acting as target of activators and repressors; forms part of the tail domain of mediator negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II transcriptional preinitiation complex assembly|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly|TFIIE-class binding transcription factor activity|RNA polymerase II activating transcription factor binding|TFIIE-class transcription factor binding|TFIIH-class transcription factor binding|RNA polymerase II transcription factor recruiting transcription factor activity core mediator complex
YPL054W YPL054W LEE1 hom Verified 0.530416867166603 0.297911466971615 no 1431 0.268001402727925 924 NA Zinc-finger protein of unknown function biological_process molecular_function cellular_component
YOL085C_d YOL085C YOL085C hom Dubious 0.528051179980737 0.298731906983858 no 1432 0.299143060432959 1012 NA Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOL085W-A Unknown Unknown Unknown
YJL185C YJL185C ATG36 hom Verified 0.527715198080002 0.298848511548897 no 1433 0.288702781985709 970 NA Pex3p interacting protein, required for pexophagy; interacts with Atg8p and Atg11p; mRNA is weakly cell cycle regulated, peaking in G2 phase; YJL185C is a non-essential gene peroxisome degradation molecular_function peroxisome
YJL043W_p YJL043W YJL043W hom Uncharacterized 0.527226950171266 0.299017997811877 no 1434 0.256703943393929 864 NA FT MITOCHONDRION Putative protein of unknown function; YJL043W is a non-essential gene biological_process molecular_function mitochondrion|cytoplasm
YKL027W YKL027W YKL027W hom Verified 0.52710419588845 0.29906061656422 no 1435 0.302765540915681 1025 NA FT MITOCHONDRION Protein of unknown function, localized to the mitochondrial outer membrane biological_process molecular_function mitochondrial outer membrane|mitochondrion
YLR287C_p YLR287C YLR287C hom Uncharacterized 0.526957747234416 0.299111465313518 no 1436 0.287636914411202 955 NA Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR287C is not an essential gene biological_process molecular_function cytoplasm
YBR094W YBR094W PBY1 hom Verified 0.526040550329358 0.299430016426121 no 1437 0.284549806435047 956 NA Putative tubulin tyrosine ligase associated with P-bodies; forms cytoplasmic foci upon DNA replication stress nuclear-transcribed mRNA catabolic process|biological_process molecular_function cytoplasmic mRNA processing body|cytoplasm
YDR296W YDR296W MHR1 hom Verified 0.52548283838283 0.299623790203376 no 1438 0.314488847851349 1070 NA FT MITOCHONDRION ORGANIZATION|RESPONSE TO OXIDATIVE STRESS NUCLEUS|MITOCHONDRION Protein involved in homologous recombination in mitochondria; required for recombination-dependent mtDNA partitioning; involved in stimulation of mitochondrial DNA replication in response to oxidative stress cellular response to oxidative stress|positive regulation of mitochondrial DNA replication|regulation of transcription, DNA-dependent|mitochondrial genome maintenance|DNA recombination single-stranded DNA binding|recombinase activity|DNA binding mitochondrion|nucleus
YNL042W-B_p YNL042W-B YNL042W-B hom Uncharacterized 0.525169493816369 0.299732684876103 no 1439 0.277213080658234 963 NA Putative protein of unknown function biological_process molecular_function cellular_component
YJL161W_p YJL161W FMP33 hom Uncharacterized 0.525083608924261 0.299762535043715 no 1440 0.280761429314919 952 NA FT MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process molecular_function mitochondrion
YDR069C YDR069C DOA4 hom Verified 0.522103177766579 0.300799247027885 no 1441 0.32252676934796 1090 NA FT VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|PROTEOLYSIS MITOCHONDRION Ubiquitin isopeptidase, required for recycling ubiquitin from proteasome-bound ubiquitinated intermediates, acts at the late endosome/prevacuolar compartment to recover ubiquitin from ubiquitinated membrane proteins en route to the vacuole protein deubiquitination|endocytosis|regulation of DNA replication|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|free ubiquitin chain depolymerization|ubiquitin homeostasis|ubiquitin-dependent protein catabolic process endopeptidase activity|ubiquitin-specific protease activity|ubiquitin thiolesterase activity endosome|proteasome complex|mitochondrion
YGL211W YGL211W NCS6 hom Verified 0.522088429051798 0.300804381234871 no 1442 0.302659872325577 1060 NA FT RNA PROCESSING MITOCHONDRION Protein required for thiolation of the uridine at the wobble position of Gln, Lys, and Glu tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae tRNA wobble position uridine thiolation|protein urmylation|tRNA wobble uridine modification tRNA binding cytosol|mitochondrion
YNR012W YNR012W URK1 hom Verified 0.521694197437943 0.300941632703355 no 1443 0.315591354075849 1091 NA FT NUCLEOTIDE METABOLISM NUCLEUS Uridine/cytidine kinase, component of the pyrimidine ribonucleotide salvage pathway that converts uridine into UMP and cytidine into CMP; involved in the pyrimidine deoxyribonucleotide salvage pathway, converting deoxycytidine into dCMP pyrimidine-containing compound salvage uridine kinase activity nucleus|cytoplasm
YDR351W YDR351W SBE2 hom Verified 0.520624767023568 0.301314096294754 no 1444 0.303110412766251 1058 NA FT PROTEIN LOCALIZATION|CELL WALL ORG/BIOGENESIS GOLGI APPARATUS Protein involved in the transport of cell wall components from the Golgi to the cell surface; required for bud growth fungal-type cell wall organization molecular_function Golgi apparatus
YPL135W YPL135W ISU1 hom Verified 0.52047521058123 0.301366200683543 no 1445 0.30838354453519 1036 NA FT RNA PROCESSING|ION HOMEOSTASIS|ION HOMEOSTASIS|COFACTOR METABOLISM MITOCHONDRION Conserved protein of the mitochondrial matrix, performs a scaffolding function during assembly of iron-sulfur clusters, interacts physically and functionally with yeast frataxin (Yfh1p); isu1 isu2 double mutant is inviable cellular iron ion homeostasis|iron-sulfur cluster assembly|tRNA wobble uridine modification ferrous iron binding mitochondrion|mitochondrial matrix
YFL047W YFL047W RGD2 hom Verified 0.520323794737181 0.301418957006449 no 1446 0.306736245265534 1035 NA FT SIGNALING SITE OF POLARIZED GROWTH GTPase-activating protein (RhoGAP) for Cdc42p and Rho5p; relocalizes from bud neck to cytoplasm upon DNA replication stress small GTPase mediated signal transduction Rho GTPase activator activity cellular bud neck|cytoplasm
YGR001C_p YGR001C YGR001C hom Uncharacterized 0.520185340472157 0.301467200892863 no 1447 0.273768568904247 925 NA Putative protein of unknown function with similarity to methyltransferase family members; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; required for replication of Brome mosaic virus in S. cerevisiae biological_process methyltransferase activity cytoplasm
YBR116C_d YBR116C YBR116C hom Dubious 0.519045167178138 0.301864622207295 no 1448 0.284001660899493 927 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene TKL2 Unknown Unknown Unknown
YLR124W_d YLR124W YLR124W hom Dubious 0.517959354937945 0.302243314024808 no 1449 0.302553602040531 1041 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YLL041C YLL041C SDH2 hom Verified 0.517560147723487 0.302382596560143 no 1450 0.296833623839267 981 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION Iron-sulfur protein subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain mitochondrial electron transport, succinate to ubiquinone|cellular respiration|tricarboxylic acid cycle succinate dehydrogenase (ubiquinone) activity mitochondrial respiratory chain complex II|mitochondrion|mitochondrial membrane
YLR058C YLR058C SHM2 hom Verified 0.515110207879334 0.303238004968338 no 1451 0.299535581149591 1012 NA FT KETONE METABOLISM|AMINO ACID METABOLISM SITE OF POLARIZED GROWTH Cytosolic serine hydroxymethyltransferase, converts serine to glycine plus 5,10 methylenetetrahydrofolate; major isoform involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis one-carbon metabolic process glycine hydroxymethyltransferase activity plasma membrane|mating projection tip|cytoplasm
YCL048W YCL048W SPS22 hom Verified 0.514867788847003 0.303322705543999 no 1452 0.300423070628514 990 NA FT CELL WALL ORG/BIOGENESIS PLASMA MEMBRANE Protein of unknown function; SPS22 has a paralog, SPS2, that arose from the whole genome duplication; redundant with Sps2p for the organization of the beta-glucan layer of the spore wall ascospore wall assembly|fungal-type cell wall organization molecular_function plasma membrane
YNR073C_p YNR073C YNR073C hom Uncharacterized 0.514240312563662 0.303541993206217 no 1453 0.340531088872291 1136 NA Putative mannitol dehydrogenase; identical in amino acid sequence to Dsf1p biological_process mannitol dehydrogenase activity cellular_component
YDR149C_d YDR149C YDR149C hom Dubious 0.513277898139163 0.30387847107626 no 1454 0.302333208553609 1043 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene NUM1; null mutation blocks anaerobic growth Unknown Unknown Unknown
YCL028W YCL028W RNQ1 hom Verified 0.512811800417688 0.304041487224738 no 1455 0.28600857009341 999 NA FT NUCLEUS [PIN(+)] prion, an infectious protein conformation that is generally an ordered protein aggregate biological_process molecular_function cytosol
YDR260C YDR260C SWM1 hom Verified 0.511277877966383 0.304578246578453 no 1456 0.309041149876819 1061 NA FT CELL CYCLE|CELL WALL ORG/BIOGENESIS|CELL DIVISION|PROTEOLYSIS NUCLEUS UBIQUITIN LIGASE COMPLEX Subunit of the anaphase-promoting complex, which is an E3 ubiquitin ligase that regulates the metaphase-anaphase transition and exit from mitosis; required for activation of the daughter-specific gene expression and spore wall maturation ascospore wall assembly|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|regulation of mitotic metaphase/anaphase transition|protein ubiquitination molecular_function anaphase-promoting complex|nucleus
YNL215W YNL215W IES2 hom Verified 0.510522354038781 0.304842778898646 no 1457 0.316785374350163 1060 NA FT NUCLEUS Protein that associates with the INO80 chromatin remodeling complex; associates with the INO80 complex under low-salt conditions; essential for growth under anaerobic conditions; protein abundance increases in response to DNA replication stress biological_process molecular_function nucleus
YBR266C_d YBR266C SLM6 hom Dubious 0.509922288174107 0.305052953258422 no 1458 0.313215717190627 1033 NA Protein with a potential role in actin cytoskeleton organization; gene exhibits synthetic genetic interaction with MSS4 encoding phosphatidylinositol 4-phosphate kinase Unknown Unknown Unknown
YCL040W YCL040W GLK1 hom Verified 0.509696892518606 0.305131915191994 no 1459 0.3109597132638 1044 NA FT CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY Glucokinase; catalyzes the phosphorylation of glucose at C6 in the first irreversible step of glucose metabolism; one of three glucose phosphorylating enzymes; expression regulated by non-fermentable carbon sources; GLK1 has a paralog, EMI2, that arose from the whole genome duplication glucose import|mannose metabolic process|glycolysis|glucose metabolic process glucokinase activity cytosol|plasma membrane
YAR027W YAR027W UIP3 hom Verified 0.509288135796556 0.305275136396269 no 1460 0.302081991953176 1027 NA FT ENDOMEMBRANE SYSTEM|NUCLEUS|PLASMA MEMBRANE Putative integral membrane protein of unknown function; interacts with Ulp1p at the nuclear periphery; member of DUP240 gene family biological_process molecular_function nuclear envelope
YFL048C YFL048C EMP47 hom Verified 0.508868981669033 0.305422031634892 no 1461 0.303174160556668 1025 NA FT VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport ER to Golgi vesicle-mediated transport glycoprotein binding fungal-type vacuole membrane|integral to endoplasmic reticulum membrane|integral to Golgi membrane|ER to Golgi transport vesicle
YHR012W YHR012W VPS29 hom Verified 0.508850011010425 0.3054286807646 no 1462 0.321567572465401 1087 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM Endosomal protein that is a subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde transport; forms a subcomplex with Vps35p and Vps26p that selects cargo proteins for endosome-to-Golgi retrieval retrograde transport, endosome to Golgi protein transporter activity endosome|retromer complex, inner shell|retromer complex
YDR368W YDR368W YPR1 hom Verified 0.506643565447095 0.30620246732447 no 1463 0.304619821789716 1051 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|RESPONSE TO OXIDATIVE STRESS NUCLEUS NADPH-dependent aldo-keto reductase; reduces multiple substrates including 2-methylbutyraldehyde and D,L-glyceraldehyde, expression is induced by osmotic and oxidative stress; functionally redundant with other aldo-keto reductases; protein abundance increases in response to DNA replication stress; YPR1 has a paralog, GCY1, that arose from the whole genome duplication cellular response to oxidative stress|D-xylose catabolic process|arabinose catabolic process glucose 1-dehydrogenase (NADP+) activity|alditol:NADP+ 1-oxidoreductase activity|carbonyl reductase (NADPH) activity nucleus|cytoplasm
YML024W YML024W RPS17A hom Verified 0.50641961836878 0.30628105258092 no 1464 0.290610462982739 1005 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Ribosomal protein 51 (rp51) of the small (40s) subunit; homologous to mammalian ribosomal protein S17, no bacterial homolog; RPS17A has a paralog, RPS17B, that arose from the whole genome duplication cytoplasmic translation|ribosomal small subunit assembly structural constituent of ribosome cytosolic small ribosomal subunit
YAR002C-A YAR002C-A ERP1 hom Verified 0.505632340757175 0.306557386844938 no 1465 0.271097840195487 929 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION Member of the p24 family involved in ER to Golgi transport; forms heterotrimeric complex with Erp2p, Emp24p, and Erv25p; localized to COPII-coated vesicles; ERP1 has a paralog, ERP6, that arose from the whole genome duplication ER to Golgi vesicle-mediated transport molecular_function mitochondrion|ER to Golgi transport vesicle
YJL168C YJL168C SET2 hom Verified 0.504834239931995 0.306837632356225 no 1466 0.286030757502026 960 NA FT CELL CYCLE|CHROMATIN ORGANIZATION NUCLEUS|CHROMOSOME Histone methyltransferase with a role in transcriptional elongation; methylates H3 lysine 36, which suppresses incorporation of acetylated histones and signals for the deacetylation of these histones within transcribed genes; associates with the C-terminal domain of Rpo21p; histone methylation activity is regulated by phosphorylation status of Rpo21p negative regulation of histone H3-K14 acetylation|DNA-dependent transcription, elongation|ascospore formation|regulation of transcription, DNA-dependent|histone deacetylation|regulation of DNA-dependent DNA replication initiation|histone methylation|negative regulation of antisense RNA transcription|Unknown|negative regulation of reciprocal meiotic recombination|positive regulation of histone acetylation histone methyltransferase activity|histone methyltransferase activity (H3-K36 specific) nucleus
YML090W_d YML090W YML090W hom Dubious 0.503699388082104 0.307236319221351 no 1467 0.3017356528413 1012 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YML089C; exhibits growth defect on a non-fermentable (respiratory) carbon source Unknown Unknown Unknown
YPR173C YPR173C VPS4 hom Verified 0.502987082359764 0.307486677110147 no 1468 0.334010503791157 1114 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|LIPID METABOLISM|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT ENDOPLASMIC RETICULUM AAA-ATPase involved in multivesicular body (MVB) protein sorting, ATP-bound Vps4p localizes to endosomes and catalyzes ESCRT-III disassembly and membrane release; ATPase activity is activated by Vta1p; regulates cellular sterol metabolism late endosome to vacuole transport via multivesicular body sorting pathway|protein retention in Golgi apparatus|intralumenal vesicle formation|protein homooligomerization|sterol metabolic process|late endosome to vacuole transport ATPase activity|protein homodimerization activity|ATP binding endosome|endoplasmic reticulum|membrane|cytoplasm
YDL076C YDL076C RXT3 hom Verified 0.501918690356126 0.307862358710291 no 1469 0.317079366841121 1061 NA FT CHROMATIN ORGANIZATION NUCLEUS|CHROMOSOME Subunit of the RPD3L complex; involved in histone deacetylation; protein abundance increases in response to DNA replication stress negative regulation of transcription from RNA polymerase I promoter molecular_function Rpd3L-Expanded complex|nucleus|Rpd3L complex
YIL057C YIL057C RGI2 hom Verified 0.501060915525359 0.308164126273463 no 1470 0.324002422888213 1097 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY Protein of unknown function involved in energy metabolism under respiratory conditions; expression induced under carbon limitation and repressed under high glucose energy reserve metabolic process molecular_function cytoplasm
YNL198C_d YNL198C YNL198C hom Dubious 0.500847474846258 0.308239235458618 no 1471 0.299294769916084 1006 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YIL006W YIL006W YIA6 hom Verified 0.500651512891854 0.308308200999201 no 1472 0.321036539441186 1090 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION Mitochondrial NAD+ transporter, involved in the transport of NAD+ into the mitochondria (see also YEA6); member of the mitochondrial carrier subfamily; disputed role as a pyruvate transporter; has putative mouse and human orthologs transport|mitochondrial pyruvate transport|NAD transmembrane transport pyruvate secondary active transmembrane transporter activity|transporter activity|NAD transporter activity mitochondrion|integral to membrane|mitochondrial inner membrane
YLL009C YLL009C COX17 hom Verified 0.500164854723009 0.308479501486286 no 1473 0.299017507781257 982 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS MITOCHONDRION Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs mitochondrial respiratory chain complex IV assembly|intracellular copper ion transport copper chaperone activity cytosol|mitochondrion|mitochondrial intermembrane space
YIL036W YIL036W CST6 hom Verified 0.499961109912912 0.308551230710322 no 1474 0.232220151393128 844 NA FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS NUCLEUS Basic leucine zipper (bZIP) transcription factor, in ATF/CREB family; mediates transcriptional activation of NCE103 (encoding carbonic anhydrase) in response to low CO2 levels such as in the ambient air; proposed to be a regulator of oleate responsive genes; involved in utilization of non-optimal carbon sources and chromosome stability; CST6 has a paralog, ACA1, that arose from the whole genome duplication cellular response to carbon dioxide|positive regulation of transcription from RNA polymerase II promoter by oleic acid|cellular response to oleic acid|positive regulation of transcription from RNA polymerase II promoter|DNA metabolic process sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus
YGL249W YGL249W ZIP2 hom Verified 0.499309573214073 0.308780655999923 no 1475 0.274879678200713 925 NA FT CELL CYCLE|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME Meiosis-specific protein; involved in normal synaptonemal complex formation and pairing between homologous chromosomes during meiosis; relocalizes from mitochondrion to cytoplasm upon DNA replication stress synaptonemal complex assembly|synapsis|reciprocal meiotic recombination molecular_function synaptonemal complex
YJL217W YJL217W REE1 hom Verified 0.498690252024196 0.308998806462845 no 1476 0.312582586806019 1043 NA Cytoplasmic protein involved in the regulation of enolase (ENO1); mRNA expression is induced by calcium shortage, copper deficiency (via Mac1p) and the presence of galactose (via Gal4p); mRNA expression is also regulated by the cell cycle biological_process molecular_function cytoplasm
YFR053C YFR053C HXK1 hom Verified 0.498151612174235 0.309188592422804 no 1477 0.329649869447138 1118 NA FT CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Hexokinase isoenzyme 1; a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves hexokinase Hxk2p; HXK1 has a paralog, HXK2, that arose from the whole genome duplication mannose metabolic process|glucose import|glycolysis|fructose import|glucose metabolic process|fructose metabolic process hexokinase activity cytosol|mitochondrion|cytoplasm
YCR025C_d YCR025C YCR025C hom Dubious 0.497816930541684 0.309306540797409 no 1478 0.328368395303813 1147 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR025C is not an essential gene Unknown Unknown Unknown
YPR171W YPR171W BSP1 hom Verified 0.497234969049661 0.309511682239255 no 1479 0.312836751155188 1072 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON Adapter that links synaptojanins Inp52p and Inp53p to the cortical actin cytoskeleton actin cortical patch localization protein binding, bridging mating projection tip|membrane|cellular bud neck|actin cortical patch|cellular bud tip
YGL107C YGL107C RMD9 hom Verified 0.497079386380007 0.309566535194523 no 1480 0.32020848784205 1073 NA FT TRANSLATION|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Mitochondrial protein required for respiratory growth; mutant phenotype and genetic interactions suggest a role in delivering mt mRNAs to ribosomes; located on matrix face of the inner membrane and loosely associated with mitoribosomes translational initiation|regulation of mRNA stability|aerobic respiration molecular_function extrinsic to mitochondrial inner membrane|mitochondrion
YEL062W YEL062W NPR2 hom Verified 0.496482380222692 0.309777057846927 no 1481 0.325028305061812 1065 NA FT SIGNALING|RESPONSE TO NUTRIENT LEVELS Subunit of SEA (Seh1-associated), Npr2/3, and Iml1p complexes; Npr2/3 complex mediates downregulation of TORC1 activity upon amino acid limitation; SEA complex is a coatomer-related complex that associates dynamically with the vacuole; Iml1p complex (Iml1p-Npr2p-Npr3p) is required for non-nitrogen-starvation (NNS)-induced autophagy; Iml1p interacts primarily with phosphorylated Npr2p; homolog of human NPRL2; target of Grr1p; required for growth on urea and proline proline transport|urea transport|regulation of TOR signaling cascade|cellular response to amino acid starvation|response to drug|cellular response to nitrogen starvation molecular_function Seh1-associated complex|extrinsic to fungal-type vacuolar membrane
YJR118C YJR118C ILM1 hom Verified 0.496131765518522 0.309900724420266 no 1482 0.336101481805026 1112 NA FF|FT MITOCHONDRION ORGANIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Protein of unknown function; may be involved in mitochondrial DNA maintenance; required for slowed DNA synthesis-induced filamentous growth mitochondrial genome maintenance molecular_function integral to membrane|endoplasmic reticulum
YKR099W YKR099W BAS1 hom Verified 0.496093856037608 0.309914096898652 no 1483 0.314743150165606 1025 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Myb-related transcription factor involved in regulating basal and induced expression of genes of the purine and histidine biosynthesis pathways; also involved in regulation of meiotic recombination at specific genes positive regulation of transcription from RNA polymerase II promoter core promoter sequence-specific DNA binding|sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|RNA polymerase II transcription factor recruiting transcription factor activity nucleus
YDR438W YDR438W THI74 hom Verified 0.495893178020583 0.309984889776434 no 1484 0.316078080661606 1028 NA FT MITOCHONDRION Mitochondrial transporter repressible by thiamine; THI74 has a paralog, YML018C, that arose from the whole genome duplication biological_process molecular_function mitochondrion|integral to membrane
YBR137W YBR137W YBR137W hom Verified 0.494173821960914 0.3105917129318 no 1485 0.290022457365199 998 NA Protein of unknown function; localized to the cytoplasm; binds to Replication Protein A (RPA); also interacts with Sgt2p; YBR137W is not an essential gene biological_process molecular_function TRC complex|cytoplasm
YJL186W YJL186W MNN5 hom Verified 0.492195557893124 0.311290552206608 no 1486 0.292731820828982 1005 NA FT CARBOHYDRATE METABOLISM GOLGI APPARATUS Alpha-1,2-mannosyltransferase, responsible for addition of the second alpha-1,2-linked mannose of the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment protein glycosylation alpha-1,2-mannosyltransferase activity Golgi apparatus
YDR357C_p YDR357C CNL1 hom Uncharacterized 0.491724652268781 0.31145700417477 no 1487 0.3024061693109 1006 NA Protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; null mutant is sensitive to drug inducing secretion of vacuolar cargo; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm biological_process molecular_function BLOC-1 complex|cytoplasm
YCL049C_p YCL049C YCL049C hom Uncharacterized 0.491647209347375 0.311484381773279 no 1488 0.314488313424446 1073 NA Protein of unknown function; localizes to membrane fraction; YCL049C is not an essential gene biological_process molecular_function membrane
YBR199W YBR199W KTR4 hom Verified 0.490343831199529 0.311945307935232 no 1489 0.272199249590144 934 NA FT CARBOHYDRATE METABOLISM GOLGI APPARATUS Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family protein N-linked glycosylation mannosyltransferase activity Golgi apparatus
YNL064C YNL064C YDJ1 hom Verified 0.490047967679744 0.312049978058369 no 1490 0.251054816082214 872 NA FT PROTEIN LOCALIZATION|PROTEOLYSIS|MITOCHONDRION ORGANIZATION Type I HSP40 co-chaperone; involved in regulation of HSP90 and HSP70 functions; critical for determining cell size at Start as a function of growth rate; involved in protein translocation across membranes; member of the DnaJ family protein refolding|ER-associated protein catabolic process|protein targeting to mitochondrion|protein targeting to ER|'de novo' protein folding unfolded protein binding|ATPase activator activity cytosol|TRC complex|perinuclear region of cytoplasm
YMR306C-A_d YMR306C-A YMR306C-A hom Dubious 0.488961788125113 0.312434375007075 no 1491 0.297939665266694 1005 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YHL016C YHL016C DUR3 hom Verified 0.487052565439848 0.313110540133403 no 1492 0.291948815100663 969 NA FT PLASMA MEMBRANE Plasma membrane transporter for both urea and polyamines, expression is highly sensitive to nitrogen catabolite repression and induced by allophanate, the last intermediate of the allantoin degradative pathway urea transport|spermidine transport|putrescine transport|urea catabolic process urea transmembrane transporter activity|spermidine transmembrane transporter activity|putrescine transmembrane transporter activity integral to membrane|plasma membrane
YFR020W_p YFR020W YFR020W hom Uncharacterized 0.486432421686011 0.313330304000653 no 1493 0.315590602139001 1036 NA Protein of unknown function; mRNA identified as translated by ribosome profiling data biological_process molecular_function cellular_component
YOR316C-A_p YOR316C-A YOR316C-A hom Uncharacterized 0.486096030069255 0.313449540751768 no 1494 0.290583806898555 961 NA Putative protein of unknown function; identified by fungal homology and RT-PCR biological_process molecular_function cellular_component
YMR021C YMR021C MAC1 hom Verified 0.485431386974773 0.313685186228664 no 1495 0.393347034896757 1350 NA FF|FT TRANSCRIPTION FROM RNA POL II|ION HOMEOSTASIS|ION HOMEOSTASIS NUCLEUS Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport cellular copper ion homeostasis|positive regulation of protein catabolic process|positive regulation of transcription from RNA polymerase II promoter core promoter proximal region DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus
YDR511W YDR511W ACN9 hom Verified 0.484429056419126 0.314040700679562 no 1496 0.274194626328776 949 NA FT KETONE METABOLISM|CARBOHYDRATE METABOLISM MITOCHONDRION Protein of the mitochondrial intermembrane space, required for acetate utilization and gluconeogenesis; has orthologs in higher eukaryotes carbon utilization|regulation of gluconeogenesis molecular_function mitochondrion|mitochondrial intermembrane space
YDR203W_d YDR203W YDR203W hom Dubious 0.484399331681629 0.314051246319754 no 1497 0.344254455324156 1169 NA FF Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YPL086C YPL086C ELP3 hom Verified 0.48432731498393 0.314076796785792 no 1498 0.315011082785189 1069 NA FT PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|RNA PROCESSING|CHROMATIN ORGANIZATION NUCLEUS Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; exhibits histone acetyltransferase activity that is directed to histones H3 and H4; disruption confers resistance to K. lactis zymotoxin regulation of transcription from RNA polymerase II promoter|tRNA wobble uridine modification histone acetyltransferase activity Elongator holoenzyme complex|nucleus|cytoplasm
YHR157W YHR157W REC104 hom Verified 0.48403484200681 0.314180571058149 no 1499 0.300128045264424 1036 NA FT CELL CYCLE NUCLEUS|CHROMOSOME Protein involved in early stages of meiotic recombination; required for meiotic crossing over; forms a complex with Rec102p and Spo11p necessary during the initiation of recombination meiotic DNA double-strand break formation|reciprocal meiotic recombination molecular_function condensed nuclear chromosome
YGL221C YGL221C NIF3 hom Verified 0.48309582355704 0.314513849682683 no 1500 0.309978140240714 1017 NA FT MITOCHONDRION Protein of unknown function, similar to Listeria monocytogenes major sigma factor (rpoD gene product); the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process molecular_function mitochondrion|cytoplasm
YIL125W YIL125W KGD1 hom Verified 0.482151574573732 0.314849137227273 no 1501 0.328725659850554 1103 NA FT KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION Component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes a key step in the tricarboxylic acid (TCA) cycle, the oxidative decarboxylation of alpha-ketoglutarate to form succinyl-CoA tricarboxylic acid cycle|2-oxoglutarate metabolic process oxoglutarate dehydrogenase (succinyl-transferring) activity mitochondrial nucleoid|mitochondrion|mitochondrial matrix|mitochondrial oxoglutarate dehydrogenase complex
YFL016C YFL016C MDJ1 hom Verified 0.481595879938833 0.315046526787255 no 1502 0.382430581944932 1258 NA FT PROTEOLYSIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Co-chaperone that stimulates the ATPase activity of the HSP70 protein Ssc1p; involved in protein folding/refolding in the mitochodrial matrix; required for proteolysis of misfolded proteins; member of the HSP40 (DnaJ) family of chaperones protein refolding|response to heat|misfolded or incompletely synthesized protein catabolic process|mitochondrial genome maintenance|'de novo' protein folding unfolded protein binding|ATPase activator activity extrinsic to mitochondrial inner membrane|mitochondrion|mitochondrial matrix
YEL052W YEL052W AFG1 hom Verified 0.481054719276027 0.315238804480081 no 1503 0.304548861749229 1029 NA FT PROTEIN LOCALIZATION|PROTEOLYSIS|RESPONSE TO OXIDATIVE STRESS|PEROXISOME ORGANIZATION MITOCHONDRION Conserved protein that may act as a chaperone in the degradation of misfolded or unassembled cytochrome c oxidase subunits; localized to matrix face of the mitochondrial inner membrane; member of the AAA family but lacks a protease domain protein import into peroxisome matrix|cellular response to oxidative stress|misfolded or incompletely synthesized protein catabolic process molecular_function mitochondrion|mitochondrial inner membrane
YHR098C YHR098C SFB3 hom Verified 0.480808211159555 0.31532640691974 no 1504 0.306167088893261 1066 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS|SITE OF POLARIZED GROWTH Component of the Sec23p-Sfb3p heterodimer of the COPII vesicle coat, required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sec24p and Sfb2p cargo loading into COPII-coated vesicle signal sequence binding COPII vesicle coat|mating projection tip
YOR291W YOR291W YPK9 hom Verified 0.479161874563231 0.315911737283985 no 1505 0.301684480011666 996 NA FT ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome biological_process molecular_function fungal-type vacuole membrane|integral to membrane
YNR065C_p YNR065C YNR065C hom Uncharacterized 0.478876934557633 0.316013090369911 no 1506 0.295163328689753 1043 NA Protein of unknown function; protein-protein interactions suggest a possible role in actin patch formation; YNR065C is not an essential gene biological_process molecular_function integral to membrane
YHL032C YHL032C GUT1 hom Verified 0.478658321161488 0.316090860474684 no 1507 0.299869792963828 1024 NA FT CARBOHYDRATE METABOLISM MITOCHONDRION Glycerol kinase, converts glycerol to glycerol-3-phosphate; glucose repression of expression is mediated by Adr1p and Ino2p-Ino4p; derepression of expression on non-fermentable carbon sources is mediated by Opi1p and Rsf1p glycerol metabolic process glycerol kinase activity mitochondrion|cytoplasm
YGL241W YGL241W KAP114 hom Verified 0.478612154829629 0.316107284847945 no 1508 0.309427298483247 1039 NA FT PROTEIN LOCALIZATION|RNA LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS Karyopherin, responsible for nuclear import of specific proteins; cargoes include Spt15p, Sua7p, histones H2A and H2B, and Nap1p; amino terminus shows similarity to those of other importins, particularly Cse1p; localization is primarily nuclear; function is regulated by sumoylation; protein abundance increases in response to DNA replication stress protein import into nucleus|transcription factor import into nucleus protein transporter activity integral to membrane|nucleus|cytoplasm
YBL021C YBL021C HAP3 hom Verified 0.476573383217394 0.316832970301376 no 1509 0.326346847252575 1111 NA FT TRANSCRIPTION FROM RNA POL II|OXIDATION-REDUCTION PROCESS|RESPONSE TO NUTRIENT LEVELS|GEN. OF PRECURSOR METABOLITES AND ENERGY NUCLEUS Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences contributing to both complex assembly and DNA binding carbon catabolite activation of transcription from RNA polymerase II promoter|regulation of cellular respiration RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription CCAAT-binding factor complex
YCL012C YCL012C YCL012C hom Verified 0.476376765832227 0.316902992117343 no 1510 0.300747823973078 989 NA Putative protein of unknown function; orthologs are present in S. bayanus, S. paradoxus and Ashbya gossypii; YCL012C is not an essential gene biological_process molecular_function cellular_component
YJR053W YJR053W BFA1 hom Verified 0.47627292256627 0.316939976712991 no 1511 0.291617189075723 979 NA FT CELL CYCLE|CELL DIVISION CYTOSKELETON Component of the GTPase-activating Bfa1p-Bub2p complex involved in multiple cell cycle checkpoint pathways that control exit from mitosis regulation of exit from mitosis|mitotic cell cycle spindle orientation checkpoint GTPase activator activity spindle pole body
YER131W YER131W RPS26B hom Verified 0.475649333911384 0.317162111178844 no 1512 0.318228105332178 1053 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S26, no bacterial homolog; RPS26B has a paralog, RPS26A, that arose from the whole genome duplication cytoplasmic translation|rRNA export from nucleus structural constituent of ribosome cytosolic small ribosomal subunit
YNL140C_p YNL140C YNL140C hom Uncharacterized 0.474929288172805 0.317418687513484 no 1513 0.362825718361161 1208 NA Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps THO2/YNL139C biological_process molecular_function cellular_component
YOR033C YOR033C EXO1 hom Verified 0.474398017664706 0.317608053198867 no 1514 0.318558416400672 1088 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE NUCLEUS 5'-3' exonuclease and flap-endonuclease; involved in recombination, double-strand break repair and DNA mismatch repair; member of the Rad2p nuclease family, with conserved N and I nuclease domains; relative distribution to the nucleus increases upon DNA replication stress mismatch repair|telomeric 3' overhang formation|DNA double-strand break processing|meiotic DNA double-strand break processing|telomere maintenance|gene conversion at mating-type locus, DNA double-strand break processing 5'-3' exonuclease activity|5'-flap endonuclease activity nucleus
YER085C_p YER085C YER085C hom Uncharacterized 0.474298122266099 0.317643665176988 no 1515 0.301011536604312 1028 NA Putative protein of unknown function biological_process molecular_function cellular_component
YGL053W YGL053W PRM8 hom Verified 0.474250918059654 0.317660493718 no 1516 0.307651187484084 1031 NA FT VESICLE-MEDIATED TRANSPORT ENDOPLASMIC RETICULUM|PLASMA MEMBRANE Pheromone-regulated protein with 2 predicted transmembrane segments and an FF sequence, a motif involved in COPII binding; forms a complex with Prp9p in the ER; member of DUP240 gene family biological_process molecular_function integral to membrane|endoplasmic reticulum|plasma membrane
YLR059C YLR059C REX2 hom Verified 0.473006491824061 0.318104273826842 no 1517 0.324965508778731 1100 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|MITOCHONDRION ORGANIZATION MITOCHONDRION 3'-5' RNA exonuclease; involved in 3'-end processing of U4 and U5 snRNAs, 5S and 5.8S rRNAs, and RNase P and RNase MRP RNA; localized to mitochondria and null suppresses escape of mtDNA to nucleus in yme1 yme2 mutants; RNase D exonuclease U5 snRNA 3'-end processing|U4 snRNA 3'-end processing|mitochondrial genome maintenance|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 3'-5'-exoribonuclease activity|3'-5' exonuclease activity mitochondrion
YGL096W YGL096W TOS8 hom Verified 0.472688529358871 0.318217705700113 no 1518 0.305867969043925 1034 NA FT NUCLEUS|CHROMOSOME Homeodomain-containing protein and putative transcription factor; found associated with chromatin; target of SBF transcription factor; induced during meiosis and under cell-damaging conditions; TOS8 has a paralog, CUP9, that arose from the whole genome duplication biological_process chromatin binding|sequence-specific DNA binding nuclear chromatin
YLR190W YLR190W MMR1 hom Verified 0.472403569870852 0.31831937837694 no 1519 0.2838982242485 958 NA FT CELL CYCLE|CELL DIVISION|MITOCHONDRION ORGANIZATION MITOCHONDRION|SITE OF POLARIZED GROWTH Phosphorylated protein of the mitochondrial outer membrane, localizes only to mitochondria of the bud; interacts with Myo2p to mediate mitochondrial distribution to buds; mRNA is targeted to the bud via the transport system involving She2p mitochondrion inheritance molecular_function mitochondrial outer membrane|incipient cellular bud site|mitochondrion|cellular bud|cellular bud neck
YBR216C YBR216C YBP1 hom Verified 0.470863587903806 0.318869075949666 no 1520 0.30983437842837 1043 NA FT RESPONSE TO OXIDATIVE STRESS Protein involved in cellular response to oxidative stress; required for oxidation of specific cysteine residues of transcription factor Yap1p, resulting in nuclear localization of Yap1p in response to stress; YBP1 has a paralog, YBP2, that arose from the whole genome duplication cellular response to oxidative stress molecular_function cytoplasm
YBR269C_p YBR269C FMP21 hom Uncharacterized 0.470688936817024 0.318931442963744 no 1521 0.319813590033404 1084 NA FT MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process molecular_function mitochondrion
YKL204W YKL204W EAP1 hom Verified 0.469482451030893 0.319362412860974 no 1522 0.342998708948988 1173 NA FT TRANSLATION eIF4E-associated protein, competes with eIF4G for binding to eIF4E; accelerates mRNA degradation by promoting decapping, facilitated by interaction with eIF4E; essential for Puf5p mediated repression; associates with Puf5p and Dhh1p; inhibits cap-dependent translation; functions independently of eIF4E to maintain genetic stability; plays a role in cell growth, implicated in the TOR signaling cascade negative regulation of translation eukaryotic initiation factor 4E binding mRNA cap binding complex|cytoplasmic stress granule
YGL039W YGL039W YGL039W hom Verified 0.469405855825705 0.319389781752958 no 1523 0.298454278137698 1005 NA FT KETONE METABOLISM|OXIDATION-REDUCTION PROCESS Oxidoreductase shown to reduce carbonyl compounds to chiral alcohols cellular ketone metabolic process|cellular aromatic compound metabolic process oxidoreductase activity, acting on CH-OH group of donors|carbonyl reductase (NADPH) activity cytoplasm
YER188W_d YER188W YER188W hom Dubious 0.469137725559722 0.319485597436915 no 1524 0.372846650420435 1224 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; large-scale analyses show mRNA expression increases under anaerobic conditions and two-hybrid interactions with Sst2p Unknown Unknown Unknown
YNL119W YNL119W NCS2 hom Verified 0.468609554420635 0.319674373331927 no 1525 0.305080029125443 1060 NA FT RNA PROCESSING Protein required for thiolation of the uridine at the wobble position of Lys(UUU) and Glu(UUC) tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae tRNA wobble position uridine thiolation|pseudohyphal growth|protein urmylation|invasive growth in response to glucose limitation molecular_function cytosol|cytoplasm
YDR061W_p YDR061W YDR061W hom Uncharacterized 0.468426298971799 0.319739882363298 no 1526 0.327447930442957 1068 NA FT NUCLEOTIDE METABOLISM MITOCHONDRION Protein with similarity to ATP-binding cassette (ABC) transporter family members; lacks predicted membrane-spanning regions; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance biological_process molecular_function mitochondrion
YLR016C YLR016C PML1 hom Verified 0.467501408421445 0.320070592331194 no 1527 0.282965271413998 973 NA FT RNA PROCESSING|RNA LOCALIZATION NUCLEUS Subunit of the RES complex, which is required for nuclear retention of unspliced pre-mRNAs; acts in the same pathway as Pml39p and Mlp1p mRNA export from nucleus|mRNA splicing, via spliceosome|maintenance of RNA location molecular_function RES complex|nucleus|cytoplasm
YOL043C YOL043C NTG2 hom Verified 0.467164616147544 0.320191053534076 no 1528 0.293942824380777 985 NA FT RESPONSE TO DNA DAMAGE NUCLEUS DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair, localizes to the nucleus; sumoylated; NTG2 has a paralog, NTG1, that arose from the whole genome duplication base-excision repair|base-excision repair, AP site formation oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity|DNA-(apurinic or apyrimidinic site) lyase activity nucleus
YHR132W-A YHR132W-A IGO2 hom Verified 0.466940446963789 0.320271243106192 no 1529 0.32478036819018 1076 NA FT NUCLEUS Protein required for initiation of G0 program; prevents degradation of nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway; phosphorylated by Rim15p; GFP protein localizes to the cytoplasm and nucleus; similar to Igo1p mRNA stabilization molecular_function nucleus|cytoplasm
YGR127W_p YGR127W YGR127W hom Uncharacterized 0.466862489752022 0.32029913184792 no 1530 0.305876099987982 1030 NA Putative protein of unknown function; expression is regulated by Msn2p/Msn4p, indicating a possible role in stress response biological_process molecular_function cellular_component
YMR109W YMR109W MYO5 hom Verified 0.466622970428955 0.320384824850435 no 1531 0.31071858799063 1051 NA FT VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS|CELL DIVISION SITE OF POLARIZED GROWTH|CYTOSKELETON One of two type I myosins; contains proline-rich tail homology 2 (TH2) and SH3 domains; MYO5 deletion has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization bipolar cellular bud site selection|endocytosis|exocytosis|fungal-type cell wall organization|response to salt stress|receptor-mediated endocytosis|actin cortical patch localization|response to osmotic stress microfilament motor activity mating projection tip|actin cortical patch
YPL104W YPL104W MSD1 hom Verified 0.466077978382674 0.320579842736 no 1532 0.342197003232119 1181 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial aspartyl-tRNA synthetase, required for acylation of aspartyl-tRNA; yeast and bacterial aspartyl-, asparaginyl-, and lysyl-tRNA synthetases contain regions with high sequence similarity, suggesting a common ancestral gene mitochondrial aspartyl-tRNA aminoacylation aspartate-tRNA ligase activity mitochondrion
YDL019C YDL019C OSH2 hom Verified 0.46572773832404 0.320705197462118 no 1533 0.345421975565702 1122 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION ENDOPLASMIC RETICULUM|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability endocytosis|maintenance of cell polarity|sterol transport|exocytosis lipid binding|oxysterol binding|sterol transporter activity|1-phosphatidylinositol binding endoplasmic reticulum|plasma membrane|cortical endoplasmic reticulum|cellular bud neck
YOL090W YOL090W MSH2 hom Verified 0.464734339646586 0.321060856867377 no 1534 0.329333856346726 1109 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|GENE SILENCING NUCLEUS|CHROMOSOME Protein that forms heterodimers with Msh3p and Msh6p that bind to DNA mismatches to initiate the mismatch repair process; contains a Walker ATP-binding motif required for repair activity and involved in interstrand cross-link repair; Msh2p-Msh6p binds to and hydrolyzes ATP mismatch repair|mitotic recombination|meiotic gene conversion|meiotic mismatch repair|removal of nonhomologous ends|DNA recombination|chromatin silencing at silent mating-type cassette loop DNA binding|single base insertion or deletion binding|ATP binding|Y-form DNA binding|double-strand/single-strand DNA junction binding|DNA insertion or deletion binding|guanine/thymine mispair binding|four-way junction DNA binding|ATPase activity MutSbeta complex|nuclear chromosome|MutSalpha complex|nucleus
YDR360W_d YDR360W OPI7 hom Dubious 0.463436924049145 0.32152560854564 no 1535 0.320776326879446 1073 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene VID21/YDR359C. Unknown Unknown Unknown
YMR286W YMR286W MRPL33 hom Verified 0.463087491253474 0.321650827868462 no 1536 0.315450395054 1083 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YHR110W YHR110W ERP5 hom Verified 0.461067424801176 0.32237511596128 no 1537 0.298236112417761 1014 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport vesicle-mediated transport molecular_function integral to membrane
YGL250W YGL250W RMR1 hom Verified 0.460987049275176 0.322403948314629 no 1538 0.314503255807065 1087 NA FT CELL CYCLE NUCLEUS Protein required for meiotic recombination and gene conversion; null mutant displays reduced PIS1 expression and growth defects on non-fermentable carbon sources and minimal media; GFP-fusion protein localizes to both cytoplasm and nucleus meiotic gene conversion|reciprocal meiotic recombination molecular_function nucleus|cytoplasm
YAL042W YAL042W ERV46 hom Verified 0.459471329848367 0.322947867898571 no 1539 0.334744506527774 1113 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS Protein localized to COPII-coated vesicles, forms a complex with Erv41p; involved in the membrane fusion stage of transport ER to Golgi vesicle-mediated transport molecular_function integral to endoplasmic reticulum membrane|integral to Golgi membrane|ER to Golgi transport vesicle
YJL028W YJL028W YJL028W hom Verified 0.459443803820422 0.322957749186562 no 1540 0.282701665047424 968 NA Protein of unknown function; may interact with ribosomes, based on co-purification experiments biological_process molecular_function ribosome
YIL092W_p YIL092W YIL092W hom Uncharacterized 0.458835616657022 0.323176107965953 no 1541 0.322271370383046 1088 NA FT NUCLEUS Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus biological_process molecular_function nucleus|cytoplasm
YNL253W YNL253W TEX1 hom Verified 0.458137355476996 0.323426881364815 no 1542 0.310170783662435 1045 NA FT RNA LOCALIZATION NUCLEUS Protein involved in mRNA export, component of the transcription export (TREX) complex mRNA export from nucleus molecular_function transcription export complex
YBR267W YBR267W REI1 hom Verified 0.458028500014515 0.323465982928262 no 1543 0.327122512144812 1132 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RIBOSOME BIOGENESIS|CELL DIVISION RIBOSOME Cytoplasmic pre-60S factor; required for the correct recycling of shuttling factors Alb1, Arx1 and Tif6 at the end of the ribosomal large subunit biogenesis; involved in bud growth in the mitotic signaling network ribosomal large subunit biogenesis|nucleocytoplasmic transport|mitotic cell cycle|budding cell bud growth sequence-specific DNA binding cytosolic large ribosomal subunit|preribosome, large subunit precursor|cytoplasm
YDR239C YDR239C YDR239C hom Verified 0.45786386817008 0.323525123421067 no 1544 0.326026227930511 1107 NA Protein of unknown function that may interact with ribosomes, based on co-purification experiments biological_process molecular_function ribosome|cytoplasm
YDL204W YDL204W RTN2 hom Verified 0.457729453890472 0.323573412201491 no 1545 0.334581092543172 1137 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Reticulon protein; stabilizes membrane curvature; involved in nuclear pore assembly and maintenance of tubular ER morphology; interacts with exocyst subunit Sec6p, Yip3p, and Sbh1p; much less abundant than Rtn1p; rtn1 rtn2 yop1 triple mutant lacks tubular ER; member of RTNLA (reticulon-like A) subfamily; protein increases in abundance and relocalizes to plasma membrane upon DNA replication stress; RTN2 has a paralog, RTN1, that arose from the whole genome duplication endoplasmic reticulum tubular network organization|endoplasmic reticulum tubular network maintenance molecular_function endoplasmic reticulum|cortical endoplasmic reticulum|endoplasmic reticulum tubular network
YDL189W YDL189W RBS1 hom Verified 0.456929243980906 0.323860951763916 no 1546 0.311570659905758 1051 NA FT CARBOHYDRATE METABOLISM Protein of unknown function, identified as a high copy suppressor of psk1 psk2 mutations that confer temperature-sensitivity for galactose utilization; proposed to bind single-stranded nucleic acids via its R3H domain galactose metabolic process molecular_function cytoplasm
YHR131C_p YHR131C YHR131C hom Uncharacterized 0.456254162168474 0.324103610807986 no 1547 0.305022742267297 1023 NA Putative protein of unknown function; GFP-fusion protein localizes to the cytoplasm; overexpression causes cell cycle delay or arrest; contains a PH domain and binds phosphatidylinositols and other lipids in a large-scale study biological_process molecular_function cytoplasm
YNL328C YNL328C MDJ2 hom Verified 0.454291712717541 0.324809440026171 no 1548 0.344424203093751 1163 NA FT PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Constituent of the mitochondrial import motor associated with the presequence translocase; function overlaps with that of Pam18p; stimulates the ATPase activity of Ssc1p to drive mitochondrial import; contains a J domain protein import into mitochondrial matrix protein transporter activity|ATPase activator activity mitochondrial inner membrane|presequence translocase-associated import motor
YOR346W YOR346W REV1 hom Verified 0.454090828740509 0.324881727012894 no 1549 0.301275372631791 991 NA FT RESPONSE TO DNA DAMAGE NUCLEUS|MITOCHONDRION|CHROMOSOME Deoxycytidyl transferase; involved in repair of abasic sites and adducted guanines in damaged DNA by translesion synthesis (TLS); forms a complex with the subunits of DNA polymerase zeta, Rev3p and Rev7p; relocalizes from nucleus to cytoplasm upon DNA replication stress error-prone translesion synthesis|error-free translesion synthesis deoxycytidyl transferase activity|DNA-directed DNA polymerase activity nuclear chromatin|mitochondrion|replication fork
YDR431W_d YDR431W YDR431W hom Dubious 0.453646563349251 0.325041616868476 no 1550 0.299592761533495 1009 NA Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YKL124W YKL124W SSH4 hom Verified 0.453485604938968 0.325099553298766 no 1551 0.282033299142609 975 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEOLYSIS|VACUOLAR TRANSPORT Specificity factor required for Rsp5p-dependent ubiquitination and sorting of cargo proteins at the multivesicular body; identified as a high-copy suppressor of a SHR3 deletion, increasing steady-state levels of amino acid permeases protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|vesicle-mediated transport molecular_function fungal-type vacuole
YFR046C YFR046C CNN1 hom Verified 0.453239201318974 0.325188253632657 no 1552 0.312246765975268 1069 NA FT CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME KINETOCHORE Kinetochore protein; associated with the essential kinetochore proteins Nnf1p and Spc24p; phosphorylated by Clb5-Cdk1, Mps1p, Ipl1p and to a lesser extent by Clb2-Cdk1; localizes to the lower region of the Ndc80 complex during anaphase and regulates KMN activity by inhibiting the Mtw1 and Spc105 complexes from binding to the Ndc80 complex; similar to metazoan CENP-T chromosome segregation molecular_function nucleus|kinetochore
YKL169C_d YKL169C YKL169C hom Dubious 0.449966925881984 0.326367144487958 no 1553 0.34744055162133 1160 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene MRPL38 Unknown Unknown Unknown
YIR044C YIR044C YIR044C hom pseudogene 0.449637933954177 0.326485765491337 no 1554 0.326817871638962 1096 NA Possible pseudogene in strain S288C; YIR044C and the adjacent ORF, YIR043C, together may encode a non-functional member of the conserved, often subtelomerically-encoded Cos protein family biological_process molecular_function cellular_component
YMR259C YMR259C TRM732 hom Verified 0.448916324395532 0.3267460097627 no 1555 0.336593696138237 1124 NA Interacts with Trm7p for 2'-O-methylation of C32 of substrate tRNAs; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; non-essential gene biological_process molecular_function cytoplasm
YGR033C YGR033C TIM21 hom Verified 0.448251442797907 0.326985870064465 no 1556 0.319591599567571 1067 NA FT PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Nonessential subunit of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); interacts with the Translocase of the Outer Mitochondrial membrane (TOM complex) and with respiratory enzymes; may regulate TIM23 complex activity protein import into mitochondrial matrix molecular_function mitochondrion|mitochondrial inner membrane presequence translocase complex
YOL025W YOL025W LAG2 hom Verified 0.447457229606465 0.327272481272304 no 1557 0.335630094777123 1111 NA FT MITOCHONDRION Protein that negatively regulates the SCF E3-ubiquitin ligase by interacting with and preventing neddyation of the cullin subunit, Cdc53p; longevity determinant that is preferentially expressed in young cells; similar to mammalian Cand1 replicative cell aging|negative regulation of ubiquitin-protein ligase activity molecular_function mitochondrion
YDL191W YDL191W RPL35A hom Verified 0.446818412622875 0.327503087898118 no 1558 0.331047682141909 1130 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Ribosomal 60S subunit protein L35A; homologous to mammalian ribosomal protein L35 and bacterial L29; RPL35A has a paralog, RPL35B, that arose from the whole genome duplication cytoplasmic translation|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) structural constituent of ribosome cytosolic large ribosomal subunit|preribosome, large subunit precursor
YGR233C YGR233C PHO81 hom Verified 0.446658533296852 0.327560813059599 no 1559 0.339668566564897 1120 NA FT LIPID METABOLISM NUCLEUS Cyclin-dependent kinase (CDK) inhibitor; regulates Pho80p-Pho85p and Pcl7p-Pho85p cyclin-CDK complexes in response to phosphate levels; inhibitory activity for Pho80p-Pho85p requires myo-D-inositol heptakisphosphate (IP7) generated by Vip1p; relative distribution to the nucleus increases upon DNA replication stress phosphate-containing compound metabolic process cyclin-dependent protein kinase inhibitor activity nucleus|cytoplasm
YNL130C YNL130C CPT1 hom Verified 0.446533919305298 0.327605808369657 no 1560 0.320770468707 1085 NA FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION|GOLGI APPARATUS Cholinephosphotransferase; required for phosphatidylcholine biosynthesis and for inositol-dependent regulation of EPT1 transcription; CPT1 has a paralog, EPT1, that arose from the whole genome duplication CDP-choline pathway diacylglycerol cholinephosphotransferase activity mitochondrial outer membrane|integral to membrane|Golgi apparatus
YER016W YER016W BIM1 hom Verified 0.445580264616545 0.327950234491216 no 1561 0.326669729153371 1102 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION CHROMOSOME|CYTOSKELETON KINETOCHORE Microtubule-binding protein that together with Kar9p makes up the cortical microtubule capture site and delays the exit from mitosis when the spindle is oriented abnormally nuclear migration along microtubule|microtubule nucleation|microtubule depolymerization|negative regulation of microtubule depolymerization|positive regulation of microtubule polymerization|mitotic sister chromatid cohesion|mitotic cell cycle spindle assembly checkpoint microtubule plus-end binding|protein homodimerization activity|structural constituent of cytoskeleton spindle midzone|microtubule plus end|cytoplasmic microtubule|spindle pole body|kinetochore|spindle pole|spindle
YGR053C_p YGR053C YGR053C hom Uncharacterized 0.444810584677115 0.328228322246202 no 1562 0.327167749487607 1099 NA Putative protein of unknown function biological_process molecular_function cellular_component
YLR401C YLR401C DUS3 hom Verified 0.441171609776342 0.329544382330372 no 1563 0.277399459647018 939 NA FT RNA PROCESSING|OXIDATION-REDUCTION PROCESS NUCLEUS Dihydrouridine synthase; member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus4p; contains a consensus oleate response element (ORE) in its promoter region; forms nuclear foci upon DNA replication stress tRNA modification tRNA dihydrouridine synthase activity nucleus|cytoplasm
YNR041C YNR041C COQ2 hom Verified 0.43982122252809 0.330033297765437 no 1564 0.330031764503176 1112 NA FT KETONE METABOLISM|LIPID METABOLISM|COFACTOR METABOLISM MITOCHONDRION Para hydroxybenzoate: polyprenyl transferase, catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis ubiquinone biosynthetic process 4-hydroxybenzoate octaprenyltransferase activity mitochondrion|integral to mitochondrial membrane|integral to membrane
YFL032W_d YFL032W YFL032W hom Dubious 0.438773275955942 0.33041291302921 no 1565 0.339863785467983 1122 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene HAC1/YFL031W; YFL032W is not an essential gene Unknown Unknown Unknown
YJR040W YJR040W GEF1 hom Verified 0.437885326529933 0.330734706498735 no 1566 0.330547195971811 1142 NA FF|FT ION HOMEOSTASIS|ION HOMEOSTASIS ENDOPLASMIC RETICULUM|GOLGI APPARATUS|PLASMA MEMBRANE Voltage-gated chloride channel localized to the golgi, the endosomal system, and plasma membrane, and involved in cation homeostasis; highly homologous to vertebrate voltage-gated chloride channels; modulates TBSV model (+) RNA virus replication by regulating copper metabolism cellular copper ion homeostasis|cellular iron ion homeostasis voltage-gated chloride channel activity endosome|integral to membrane|endoplasmic reticulum|Golgi apparatus|plasma membrane|fungal-type vacuole|Golgi medial cisterna
YDR269C_d YDR269C YDR269C hom Dubious 0.437428508917847 0.330900306273843 no 1567 0.322561117617292 1068 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YPR052C YPR052C NHP6A hom Verified 0.434767529956872 0.331865587853439 no 1568 0.323334008445644 1093 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME High-mobility group (HMG) protein, binds to and remodels nucleosomes; involved in recruiting FACT and other chromatin remodelling complexes to chromosomes; functionally redundant with Nhp6Bp; homologous to mammalian HMGB1 and HMGB2; NHP6A has a paralog, NHP6B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress mismatch repair|DNA replication-independent nucleosome organization|RNA polymerase II transcriptional preinitiation complex assembly|RNA polymerase III transcriptional preinitiation complex assembly|chromatin remodeling nucleosome binding|sequence-specific DNA binding|DNA binding, bending MutSalpha complex|nucleus
YDR019C YDR019C GCV1 hom Verified 0.434640308945642 0.331911765855432 no 1569 0.344675201716802 1183 NA FT KETONE METABOLISM|AMINO ACID METABOLISM MITOCHONDRION T subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of levels of 5,10-methylene-THF in the cytoplasm glycine catabolic process|glycine metabolic process|one-carbon metabolic process glycine dehydrogenase (decarboxylating) activity mitochondrion|glycine cleavage complex
YLR083C YLR083C EMP70 hom Verified 0.431178644273821 0.333169240357367 no 1570 0.361449118084436 1207 NA FT VESICLE-MEDIATED TRANSPORT|ION HOMEOSTASIS|ION HOMEOSTASIS|VACUOLAR TRANSPORT Protein with a role in cellular adhesion, filamentous growth, and endosome-to-vacuole sorting; similar to Tmn2p and Tmn3p; member of Transmembrane Nine family of proteins with 9 transmembrane segments cellular copper ion homeostasis|vacuolar transport|pseudohyphal growth|endosomal transport|invasive growth in response to glucose limitation molecular_function endosome|fungal-type vacuole membrane|integral to membrane
YLR113W YLR113W HOG1 hom Verified 0.431132776710697 0.333185914714276 no 1571 0.363117366414479 1202 NA FT TRANSCRIPTION FROM RNA POL II|SIGNALING|PROTEIN PHOSPHORYLATION NUCLEUS Mitogen-activated protein kinase involved in osmoregulation; controls global reallocation of RNA Pol II in response to osmotic shock; acts via three independent osmosensors; mitophagy-specific regulator; mediates the recruitment and activation of RNA Pol II at Hot1p-dependent promoters; localization regulated by Ptp2p and Ptp3p; protein abundance increases in response to DNA replication stress negative regulation of transcription from RNA polymerase II promoter by pheromones|protein phosphorylation|hyperosmotic response|response to arsenic-containing substance|osmosensory signaling pathway|positive regulation of transcription from RNA polymerase II promoter|cellular response to heat MAP kinase activity nucleus|cytoplasm
YNR044W YNR044W AGA1 hom Verified 0.430755806429492 0.333322968209459 no 1572 0.295553645924162 1026 NA Anchorage subunit of a-agglutinin of a-cells, highly O-glycosylated protein with N-terminal secretion signal and C-terminal signal for addition of GPI anchor to cell wall, linked to adhesion subunit Aga2p via two disulfide bonds agglutination involved in conjugation with cellular fusion cell adhesion molecule binding fungal-type cell wall
YDR503C YDR503C LPP1 hom Verified 0.430563543399183 0.333392877039962 no 1573 0.320710841174902 1070 NA FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Lipid phosphate phosphatase, catalyzes Mg(2+)-independent dephosphorylation of phosphatidic acid (PA), lysophosphatidic acid, and diacylglycerol pyrophosphate; involved in control of the cellular levels of phosphatidylinositol and PA phospholipid metabolic process phosphatidate phosphatase activity integral to membrane|membrane
YDR466W YDR466W PKH3 hom Verified 0.428226278343742 0.334243193028374 no 1574 0.371440773874771 1265 NA FF|FT SIGNALING|CELL WALL ORG/BIOGENESIS|PROTEIN PHOSPHORYLATION Protein kinase with similarity to mammalian phosphoinositide-dependent kinase 1 (PDK1) and yeast Pkh1p and Pkh2p, two redundant upstream activators of Pkc1p; identified as a multicopy suppressor of a pkh1 pkh2 double mutant MAPK cascade involved in cell wall biogenesis|protein phosphorylation protein kinase activity cellular_component
YDL219W YDL219W DTD1 hom Verified 0.427043752429969 0.334673730172072 no 1575 0.31231799953283 1061 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION D-Tyr-tRNA(Tyr) deacylase, functions in protein translation, may affect nonsense suppression via alteration of the protein synthesis machinery; ubiquitous among eukaryotes Unknown D-leucyl-tRNA(Leu) deacylase activity|D-tyrosyl-tRNA(Tyr) deacylase activity cytoplasm
YMR137C YMR137C PSO2 hom Verified 0.426549060222045 0.334853903557426 no 1576 0.317347961010816 1063 NA FT RESPONSE TO DNA DAMAGE NUCLEUS Nuclease required for DNA single- and double-strand break repair; acts at a post-incision step in repair of breaks that result from interstrand cross-links produced by a variety of mono- and bi-functional psoralen derivatives; induced by UV-irradiation; forms nuclear foci upon DNA replication stress DNA repair|double-strand break repair damaged DNA binding|5'-3' exonuclease activity nucleus
YDL063C YDL063C SYO1 hom Verified 0.426459515927946 0.334886520828044 no 1577 0.346789416703159 1149 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS NUCLEUS Transport adaptor or symportin; facilitates synchronized nuclear coimport of the two 5S-rRNA binding proteins Rpl5p and Rpl11p; required for biogenesis of the large ribosomal subunit; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus ribosomal large subunit biogenesis molecular_function nucleus|cytoplasm
YJR130C YJR130C STR2 hom Verified 0.425511672191914 0.335231857301193 no 1578 0.329469047263141 1081 NA FT KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS Cystathionine gamma-synthase, converts cysteine into cystathionine sulfur compound metabolic process|transsulfuration cystathionine gamma-synthase activity nucleus|cytoplasm
YML103C YML103C NUP188 hom Verified 0.425267500940713 0.335320840995497 no 1579 0.312819230375461 1047 NA FT PROTEIN LOCALIZATION|RNA LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS NUCLEAR PORE Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188 nuclear pore organization|protein import into nucleus|mRNA export from nucleus in response to heat stress structural constituent of nuclear pore integral to membrane|nuclear pore|nuclear pore inner ring
YOR064C YOR064C YNG1 hom Verified 0.424856364888325 0.335470692798395 no 1580 0.339706064692226 1143 NA FT CHROMATIN ORGANIZATION NUCLEUS HISTONE ACETYLTRANSFERASE Subunit of the NuA3 histone acetyltransferase complex that acetylates histone H3; contains PHD finger domain that interacts with methylated histone H3, has similarity to the human tumor suppressor ING1 histone acetylation|chromatin modification histone acetyltransferase activity|methylated histone residue binding NuA3 histone acetyltransferase complex
YPR020W YPR020W ATP20 hom Verified 0.424711859120874 0.335523368807415 no 1581 0.332682728712688 1144 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS MITOCHONDRION Subunit g of the mitochondrial F1F0 ATP synthase; reversibly phosphorylated on two residues; unphosphorylated form is required for dimerization of the ATP synthase complex protein oligomerization|cristae formation|protein complex assembly|ATP synthesis coupled proton transport structural molecule activity|proton-transporting ATPase activity, rotational mechanism mitochondrion|mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
YPR072W YPR072W NOT5 hom Verified 0.424306344089754 0.335671206561091 no 1582 0.33938263455005 1128 NA FT TRANSCRIPTION FROM RNA POL II|RNA PROCESSING NUCLEUS Subunit of the CCR4-NOT complex, which is a global transcriptional regulator with roles in transcription initiation and elongation and in mRNA degradation deadenylation-independent decapping of nuclear-transcribed mRNA|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|nuclear-transcribed mRNA poly(A) tail shortening|transcription elongation from RNA polymerase II promoter|protein ubiquitination ubiquitin-protein ligase activity CCR4-NOT core complex|cytoplasm
YOL033W YOL033W MSE1 hom Verified 0.424106069686239 0.335744229560813 no 1583 0.368904660906966 1194 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial glutamyl-tRNA synthetase, predicted to be palmitoylated mitochondrial glutamyl-tRNA aminoacylation|glutamyl-tRNA aminoacylation|mitochondrial translation glutamate-tRNA(Gln) ligase activity|glutamate-tRNA ligase activity mitochondrion
YBR125C YBR125C PTC4 hom Verified 0.423814100088153 0.335850697092066 no 1584 0.314426644315552 1043 NA Cytoplasmic type 2C protein phosphatase (PP2C); identified as a high-copy number suppressor of cnb1 mpk1 synthetic lethality; overexpression decreases high-osmolarity induced Hog1p phosphorylation and kinase activity protein dephosphorylation protein serine/threonine phosphatase activity cytoplasm
YLR311C_d YLR311C YLR311C hom Dubious 0.4234227081139 0.335993439938528 no 1585 0.342658995425872 1157 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YDR378C YDR378C LSM6 hom Verified 0.422364932280636 0.336379335030118 no 1586 0.345862889171036 1163 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA nuclear-transcribed mRNA catabolic process|mRNA splicing, via spliceosome|maturation of SSU-rRNA RNA binding U6 snRNP|nucleolus|small nucleolar ribonucleoprotein complex|U4/U6 x U5 tri-snRNP complex|cytoplasmic mRNA processing body
YCL036W YCL036W GFD2 hom Verified 0.421813907340792 0.336580426884016 no 1587 0.338019625653565 1130 NA Protein of unknown function; identified as a high-copy suppressor of a dbp5 mutation; GFD2 has a paralog, YDR514C, that arose from the whole genome duplication biological_process molecular_function cellular_component
YPR138C YPR138C MEP3 hom Verified 0.421380646949711 0.336738574399642 no 1588 0.331002017970173 1101 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE Ammonium permease of high capacity and low affinity; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation ammonia permease nitrogen utilization|ammonium transport ammonium transmembrane transporter activity integral to membrane|plasma membrane
YDL199C_p YDL199C YDL199C hom Uncharacterized 0.421197442288838 0.336805455948646 no 1589 0.317820036101519 1073 NA Putative transporter, member of the sugar porter family transport|transmembrane transport substrate-specific transmembrane transporter activity integral to membrane|membrane
YHR092C YHR092C HXT4 hom Verified 0.421152267900138 0.33682194831522 no 1590 0.293123210400642 974 NA FT PLASMA MEMBRANE High-affinity glucose transporter; member of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose; HXT4 has a paralog, HXT7, that arose from the whole genome duplication hexose transport pentose transmembrane transporter activity|mannose transmembrane transporter activity|glucose transmembrane transporter activity|fructose transmembrane transporter activity integral to membrane|plasma membrane
YHR030C YHR030C SLT2 hom Verified 0.420268894849812 0.337144515143851 no 1591 0.3945049464427 1304 NA FF|FT PROTEIN LOCALIZATION|RNA PROCESSING|SIGNALING|CELL WALL ORG/BIOGENESIS|CELL DIVISION|PROTEIN PHOSPHORYLATION|PEROXISOME ORGANIZATION NUCLEUS|SITE OF POLARIZED GROWTH Serine/threonine MAP kinase; involved in regulating maintenance of cell wall integrity, progression through the cell cycle, and nuclear mRNA retention in heat shock; required for mitophagy and pexophagy; affects recruitment of mitochondria to the phagophore assembly site (PAS); regulated by the PKC1-mediated signaling pathway protein phosphorylation|endoplasmic reticulum unfolded protein response|signal transduction|UFP-specific transcription factor mRNA processing involved in endoplasmic reticulum unfolded protein response|fungal-type cell wall organization|peroxisome degradation|regulation of transcription factor import into nucleus|barrier septum assembly|response to acid|regulation of cell size MAP kinase activity|protein serine/threonine kinase activity|protein kinase activity nucleus|cytoplasm|cellular bud tip
YNL125C YNL125C ESBP6 hom Verified 0.420240965388872 0.337154715640835 no 1592 0.333847175652402 1104 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION Protein with similarity to monocarboxylate permeases, appears not to be involved in transport of monocarboxylates such as lactate, pyruvate or acetate across the plasma membrane transport monocarboxylic acid transmembrane transporter activity|transporter activity mitochondrion|integral to membrane|endoplasmic reticulum|membrane
YJR137C YJR137C MET5 hom Verified 0.419407971922556 0.337458999480626 no 1593 0.294106313705335 992 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|CELL WALL ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS Sulfite reductase beta subunit, involved in amino acid biosynthesis, transcription repressed by methionine fungal-type cell wall organization|sulfate assimilation sulfite reductase (NADPH) activity sulfite reductase complex (NADPH)|cytoplasm
YKR069W YKR069W MET1 hom Verified 0.419154433827016 0.337551635420973 no 1594 0.338534441792124 1138 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM S-adenosyl-L-methionine uroporphyrinogen III transmethylase, involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis siroheme biosynthetic process|methionine biosynthetic process|sulfate assimilation uroporphyrin-III C-methyltransferase activity intracellular
YOL160W_d YOL160W YOL160W hom Dubious 0.418557692250234 0.337769707447199 no 1595 0.317247275436134 1070 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YOR293C-A_p YOR293C-A YOR293C-A hom Uncharacterized 0.417786884518683 0.338051470472551 no 1596 0.323879881918339 1049 NA Putative protein of unknown function; identified by expression profiling and mass spectrometry biological_process molecular_function cellular_component
YNL077W YNL077W APJ1 hom Verified 0.417759060598504 0.338061642997233 no 1597 0.360286564532245 1199 NA FT NUCLEUS|MITOCHONDRION Chaperone with a role in SUMO-mediated protein degradation; member of the DnaJ-like family; conserved across eukaryotes; overexpression interferes with propagation of the [Psi+] prion; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; forms nuclear foci upon DNA replication stress biological_process unfolded protein binding mitochondrion|nucleus|cytoplasm
YER120W YER120W SCS2 hom Verified 0.417576379732792 0.338128434711216 no 1598 0.333929411696605 1132 NA FT PROTEIN LOCALIZATION|LIPID METABOLISM|GENE SILENCING ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|SITE OF POLARIZED GROWTH Integral ER membrane protein, regulates phospholipid metabolism; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PI4P levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; interacts with FFAT motif of Opi1p; involved in telomeric silencing; null shows inositol auxotrophy above 34 deg C; VAP homolog; SCS2 has a paralog, SCS22, that arose from the whole genome duplication endoplasmic reticulum inheritance|regulation of intracellular lipid transport|negative regulation of transcription factor import into nucleus|phospholipid biosynthetic process|chromatin silencing at telomere phosphatidylinositol binding|FFAT motif binding nuclear membrane|integral to endoplasmic reticulum membrane|nuclear envelope|endoplasmic reticulum|cellular bud tip
YLR126C YLR126C YLR126C hom Verified 0.417262817528901 0.338243091091821 no 1599 0.330190114164235 1126 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|ION HOMEOSTASIS|ION HOMEOSTASIS Putative glutamine amidotransferase; has Aft1p-binding motif in the promoter; may be involved in copper and iron homeostasis; YLR126C is not an essential protein; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress cellular copper ion homeostasis|cellular iron ion homeostasis molecular_function cytoplasm
YPR073C YPR073C LTP1 hom Verified 0.415726768709565 0.338804975486781 no 1600 0.323559864174805 1089 NA FT NUCLEUS Protein phosphotyrosine phosphatase of unknown cellular role; activated by adenine protein dephosphorylation protein tyrosine phosphatase activity nucleus|cytoplasm
YKR046C YKR046C PET10 hom Verified 0.415606109979357 0.338849127490975 no 1601 0.335506928882065 1116 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY Protein of unknown function that co-purifies with lipid particles; expression pattern suggests a role in respiratory growth; computational analysis of large-scale protein-protein interaction data suggests a role in ATP/ADP exchange aerobic respiration molecular_function lipid particle
YLR035C YLR035C MLH2 hom Verified 0.414813453005604 0.339139235246308 no 1602 0.350452207885096 1175 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE NUCLEUS Protein involved in the mismatch repair of certain frameshift intermediates and involved in meiotic recombination; forms a complex with Mlh1p mismatch repair|reciprocal meiotic recombination molecular_function nucleus
YDR266C YDR266C HEL2 hom Verified 0.414539997064964 0.339239340641752 no 1603 0.346427530937971 1158 NA RING finger ubiquitin ligase (E3); involved in ubiquitylation and degradation of excess histones; interacts with Ubc4p and Rad53p; null mutant sensitive to hydroxyurea (HU); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; computational analysis suggests a role as a transcription factor biological_process molecular_function ribosome|cytoplasm
YHL019C YHL019C APM2 hom Verified 0.413485490401954 0.339625475418453 no 1604 0.335170285300353 1137 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Protein of unknown function, homologous to the medium chain of mammalian clathrin-associated protein complex; involved in vesicular transport Golgi to vacuole transport|vesicle-mediated transport clathrin binding AP-1 adaptor complex
YDR030C YDR030C RAD28 hom Verified 0.411433375270912 0.340377392640462 no 1605 0.34175897474114 1135 NA FT RESPONSE TO DNA DAMAGE NUCLEUS Protein involved in DNA repair, related to the human CSA protein that is involved in transcription-coupled repair nucleotide excision repair DNA repair molecular_function nucleus
YMR279C YMR279C YMR279C hom Verified 0.410583551890817 0.340688963254538 no 1606 0.348206780851547 1168 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS Putative boron transporter involved in boron efflux and resistance; overexpression mutant but not null mutant displays boron tolerance phenotype; identified as a heat-induced gene in a high-throughout screen; YMR279C is not an essential gene; YMR279C has a paralog, ATR1, that arose from the whole genome duplication borate transmembrane transport borate efflux transmembrane transporter activity integral to membrane
YLR201C YLR201C COQ9 hom Verified 0.410269286615211 0.340804209833358 no 1607 0.334316343313838 1114 NA FT KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes ubiquinone biosynthetic process|aerobic respiration molecular_function mitochondrion|mitochondrial inner membrane
YAL028W YAL028W FRT2 hom Verified 0.410081113323653 0.340873223387359 no 1608 0.303861740027212 1033 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Tail-anchored ER membrane protein of unknown function; interacts with homolog Frt1p; promotes growth in conditions of high Na+, alkaline pH, or cell wall stress, possibly via a role in posttranslational translocation; potential Cdc28p substrate; FRT2 has a paralog, FRT1, that arose from the whole genome duplication response to stress molecular_function endoplasmic reticulum
YML009C-A_d YML009C-A YML009C-A hom Dubious 0.409490639693283 0.34108981729363 no 1609 0.356300480006666 1205 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YAR042W YAR042W SWH1 hom Verified 0.408919647019654 0.341299315129558 no 1610 0.334401295512158 1132 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|GOLGI APPARATUS Protein similar to mammalian oxysterol-binding protein; contains ankyrin repeats; localizes to the Golgi and the nucleus-vacuole junction endocytosis|maintenance of cell polarity|exocytosis|sterol transport lipid binding|oxysterol binding|1-phosphatidylinositol binding|sterol transporter activity nuclear envelope|endoplasmic reticulum|Golgi trans cisterna|early endosome
YBR164C YBR164C ARL1 hom Verified 0.40881590402729 0.341337383800194 no 1611 0.380169571011797 1282 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING|VACUOLAR TRANSPORT GOLGI APPARATUS Soluble GTPase with a role in regulation of membrane traffic; regulates potassium influx; G protein of the Ras superfamily, similar to ADP-ribosylation factor Golgi to plasma membrane protein transport|vesicle-mediated transport|protein targeting to vacuole GTPase activity trans-Golgi network|cytosol|Golgi apparatus
YOR094W YOR094W ARF3 hom Verified 0.406823751254148 0.342068720497236 no 1612 0.32216324435647 1112 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL CYCLE|LIPID METABOLISM|MEMBRANE ORGANIZATION|SIGNALING|CELL DIVISION|CYTOSKELETON ORGANIZATION GOLGI APPARATUS|SITE OF POLARIZED GROWTH Glucose-repressible ADP-ribosylation factor, GTPase of the Ras superfamily involved in development of polarity; also has mRNA binding activity intracellular protein transport|positive regulation of phosphatidylinositol biosynthetic process|endocytosis|actin filament bundle assembly|actin cortical patch localization|cellular bud site selection mRNA binding|GTPase activity cellular bud neck|cellular bud tip
YJR070C YJR070C LIA1 hom Verified 0.406418174426629 0.342217684022136 no 1613 0.348360740075024 1164 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|CYTOSKELETON ORGANIZATION NUCLEUS Deoxyhypusine hydroxylase; HEAT-repeat containing metalloenzyme that catalyzes hypusine formation; binds to and is required for the modification of Hyp2p (eIF5A); complements S. pombe mmd1 mutants defective in mitochondrial positioning; protein abundance increases in response to DNA replication stress microtubule cytoskeleton organization|peptidyl-lysine modification to hypusine deoxyhypusine monooxygenase activity nucleus|cytoplasm
YER137C_p YER137C YER137C hom Uncharacterized 0.406177700265368 0.342306018907209 no 1614 0.348074870134403 1144 NA Putative protein of unknown function biological_process molecular_function cellular_component
YGR161C_p YGR161C RTS3 hom Uncharacterized 0.405941112713135 0.342392934520276 no 1615 0.341169825614123 1136 NA FT NUCLEUS Putative component of the protein phosphatase type 2A complex biological_process molecular_function nucleus|cytoplasm
YLR456W_p YLR456W YLR456W hom Uncharacterized 0.405845250349252 0.34242815403351 no 1616 0.317166058279341 1097 NA FT OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM NUCLEUS Putative pyridoxal 5'-phosphate synthase; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2; YLR456W has a paralog, YPR172W, that arose from the whole genome duplication biological_process molecular_function cellular_component
YHR049C-A_d YHR049C-A YHR049C-A hom Dubious 0.405474436284708 0.342564402785121 no 1617 0.327077836627064 1119 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YKR067W YKR067W GPT2 hom Verified 0.40515857185985 0.342680477469565 no 1618 0.353917977881385 1213 NA FT LIPID METABOLISM ENDOPLASMIC RETICULUM Glycerol-3-phosphate/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase located in lipid particles and the ER; involved in the stepwise acylation of glycerol-3-phosphate and dihydroxyacetone in lipid biosynthesis; the most conserved motifs and functionally relevant residues are oriented towards the ER lumen phospholipid biosynthetic process glycerol-3-phosphate O-acyltransferase activity|glycerone-phosphate O-acyltransferase activity integral to membrane|lipid particle|endoplasmic reticulum|cytoplasm
YHR153C YHR153C SPO16 hom Verified 0.405143345775848 0.342686073166103 no 1619 0.306186253164629 1065 NA FT CELL CYCLE NUCLEUS|CHROMOSOME Meiosis-specific protein involved in synaptonemal complex assembly; implicated in regulation of crossover formation; required for sporulation synaptonemal complex assembly|ascospore formation|regulation of reciprocal meiotic recombination molecular_function condensed nuclear chromosome
YMR148W YMR148W OSW5 hom Verified 0.402669673537437 0.3435956232654 no 1620 0.307745907956559 1002 NA Protein of unknown function that may play a role in spore wall assembly; predicted to contain an N-terminal transmembrane domain; osw5 null mutant spores exhibit increased spore wall permeability and sensitivity to beta-glucanase digestion biological_process molecular_function integral to membrane
YDL240W YDL240W LRG1 hom Verified 0.402257975108592 0.343747089694219 no 1621 0.349938221985535 1162 NA FT SIGNALING|CELL WALL ORG/BIOGENESIS MITOCHONDRION|SITE OF POLARIZED GROWTH Putative GTPase-activating protein (GAP) involved in the Pkc1p-mediated signaling pathway that controls cell wall integrity; appears to specifically regulate 1,3-beta-glucan synthesis fungal-type cell wall biogenesis|small GTPase mediated signal transduction Rho GTPase activator activity mitochondrion|cellular bud neck|cytoplasm
YGL217C_d YGL217C YGL217C hom Dubious 0.40047257412846 0.344404239903407 no 1622 0.331878451587864 1119 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF KIP3/YGL216W Unknown Unknown Unknown
YKL106W YKL106W AAT1 hom Verified 0.400163644277307 0.344517995061352 no 1623 0.331449062706906 1121 NA FT KETONE METABOLISM|AMINO ACID METABOLISM MITOCHONDRION Mitochondrial aspartate aminotransferase, catalyzes the conversion of oxaloacetate to aspartate in aspartate and asparagine biosynthesis aspartate catabolic process|chronological cell aging|replicative cell aging|asparagine biosynthetic process from oxaloacetate|aspartate biosynthetic process L-aspartate:2-oxoglutarate aminotransferase activity mitochondrion
YER026C YER026C CHO1 hom Verified 0.399049798860278 0.344928255553382 no 1624 0.358298177130617 1201 NA FT LIPID METABOLISM ENDOPLASMIC RETICULUM|MITOCHONDRION Phosphatidylserine synthase, functions in phospholipid biosynthesis; catalyzes the reaction CDP-diaclyglycerol + L-serine = CMP + L-1-phosphatidylserine, transcriptionally repressed by myo-inositol and choline phosphatidylserine biosynthetic process CDP-diacylglycerol-serine O-phosphatidyltransferase activity mitochondrial outer membrane|integral to membrane|endoplasmic reticulum
YGR257C YGR257C MTM1 hom Verified 0.399020383823844 0.344939092409757 no 1625 0.365851146240508 1233 NA FF|FT ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION Mitochondrial protein of the mitochondrial carrier family, involved in activating mitochondrial Sod2p probably by facilitating insertion of an essential manganese cofactor manganese ion transport|transport transporter activity|metallochaperone activity mitochondrion|integral to membrane|mitochondrial inner membrane
YER135C_d YER135C YER135C hom Dubious 0.398611950783854 0.345089577239096 no 1626 0.34577317438956 1138 NA Dubious open reading frame unlikely to encode a protein; YER135C is not an essential gene Unknown Unknown Unknown
YER122C YER122C GLO3 hom Verified 0.398237358101917 0.345227615322445 no 1627 0.348566965247384 1170 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING|NUCLEOTIDE METABOLISM ENDOMEMBRANE SYSTEM|GOLGI APPARATUS ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Gcs1p retrograde vesicle-mediated transport, Golgi to ER|COPI coating of Golgi vesicle|ER to Golgi vesicle-mediated transport ARF GTPase activator activity COPI-coated vesicle|endoplasmic reticulum-Golgi intermediate compartment|COPI vesicle coat
YER115C YER115C SPR6 hom Verified 0.398078282972498 0.345286241026935 no 1628 0.352636992383094 1161 NA FT CELL CYCLE Protein of unknown function, expressed during sporulation; not required for sporulation, but gene exhibits genetic interactions with other genes required for sporulation ascospore formation molecular_function cellular_component
YMR176W YMR176W ECM5 hom Verified 0.398001233262967 0.345314638337264 no 1629 0.336700309448241 1128 NA FT CELL WALL ORG/BIOGENESIS NUCLEUS|CHROMOSOME Non-essential protein of unknown function; contains ATP/GTP-binding site motif A; null mutant exhibits cellular volume up to four times greater than wild-type, also large drooping buds with elongated necks; relative distribution to the nucleus increases upon DNA replication stress fungal-type cell wall organization molecular_function nucleus|Snt2C complex
YPL212C YPL212C PUS1 hom Verified 0.396261915418229 0.345955909814725 no 1630 0.330712328497385 1109 NA FT RNA PROCESSING NUCLEUS tRNA:pseudouridine synthase, introduces pseudouridines at positions 26-28, 34-36, 65, and 67 of tRNA; nuclear protein that appears to be involved in tRNA export; also acts on U2 snRNA snRNA pseudouridine synthesis|tRNA pseudouridine synthesis pseudouridine synthase activity nucleus
YOL163W_p YOL163W YOL163W hom Uncharacterized 0.396045595245623 0.346035696142369 no 1631 0.333045106345775 1107 NA Putative protein of unknown function; member of the Dal5p subfamily of the major facilitator family transmembrane transport transmembrane transporter activity integral to membrane|membrane
YKR075C_p YKR075C YKR075C hom Uncharacterized 0.395623322895164 0.346191464417506 no 1632 0.346760443712942 1148 NA FT NUCLEUS Protein of unknown function; similar to YOR062Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS biological_process molecular_function nucleus|cytoplasm
YGL254W YGL254W FZF1 hom Verified 0.395267580422694 0.346322711278752 no 1633 0.355035399059408 1166 NA FT TRANSCRIPTION FROM RNA POL II|ION HOMEOSTASIS|ION HOMEOSTASIS NUCLEUS Transcription factor involved in sulfite metabolism; sole identified regulatory target is SSU1; overexpression suppresses sulfite-sensitivity of many unrelated mutants due to hyperactivation of SSU1, contains five zinc fingers; protein abundance increases in response to DNA replication stress positive regulation of sulfite transport by positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus
YDR157W_d YDR157W YDR157W hom Dubious 0.395005600157556 0.346419377514731 no 1634 0.34543538998522 1135 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YPR083W YPR083W MDM36 hom Verified 0.394553091728525 0.346586368943149 no 1635 0.356024581702299 1161 NA FT MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial protein required for normal mitochondrial morphology and inheritance; proposed involvement in the formation of Dnm1p and Num1p-containing cortical anchor complexes that promote mitochondrial fission mitochondrial fission|mitochondrion organization molecular_function mitochondrion|cytoplasm
YDR524W-C_p YDR524W-C YDR524W-C hom Uncharacterized 0.393952017114629 0.346808232590522 no 1636 0.354567413627509 1186 NA Putative protein of unknown function; small ORF identified by SAGE; deletion strains are moderately sensitive to the radiomimetic drug bleomycin biological_process molecular_function cellular_component
YLR188W YLR188W MDL1 hom Verified 0.393273331513224 0.347058806511423 no 1637 0.355815888868213 1179 NA FT NUCLEOTIDE METABOLISM MITOCHONDRION Mitochondrial inner membrane half-type ATP-binding cassette (ABC) transporter, mediates export of peptides generated upon proteolysis of mitochondrial proteins, plays a role in the regulation of cellular resistance to oxidative stress oligopeptide transport|oligopeptide export from mitochondrion ATPase activity|oligopeptide-transporting ATPase activity mitochondrion|integral to membrane|mitochondrial inner membrane
YMR159C YMR159C ATG16 hom Verified 0.393141533971714 0.347107474543659 no 1638 0.346869174597649 1165 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS Conserved protein involved in autophagy; interacts with Atg12p-Atg5p conjugates to form Atg12p-Atg5p-Atg16p multimers, which localize to the pre-autophagosomal structure and are required for autophagy; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress C-terminal protein lipidation|piecemeal microautophagy of nucleus|mitochondrion degradation|macroautophagy|CVT pathway protein binding, bridging|Atg8 ligase activity Atg12-Atg5-Atg16 complex|pre-autophagosomal structure
YBR020W YBR020W GAL1 hom Verified 0.393023803554597 0.347150950231609 no 1639 0.335520949702221 1137 NA FT CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS Galactokinase; phosphorylates alpha-D-galactose to alpha-D-galactose-1-phosphate in the first step of galactose catabolism; expression regulated by Gal4p; GAL1 has a paralog, GAL3, that arose from the whole genome duplication galactose catabolic process via UDP-galactose|carbohydrate phosphorylation|positive regulation of transcription by galactose galactokinase activity cytoplasm
YGL147C YGL147C RPL9A hom Verified 0.392746529387852 0.34725335045308 no 1640 0.349285870879323 1199 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L9A; nearly identical to paralog Rpl9Bp; homologous to mammalian ribosomal protein L9 and bacterial L6 cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YOL151W YOL151W GRE2 hom Verified 0.392685816882733 0.34727577369849 no 1641 0.321140437453638 1085 NA FT LIPID METABOLISM|OXIDATION-REDUCTION PROCESS NUCLEUS 3-methylbutanal reductase and NADPH-dependent methylglyoxal reductase (D-lactaldehyde dehydrogenase); stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway; protein abundance increases in response to DNA replication stress ergosterol metabolic process|filamentous growth methylglyoxal reductase (NADPH-dependent) activity|3-methylbutanol:NAD(P) oxidoreductase activity nucleus|cytoplasm
YMR272W-B_p YMR272W-B YMR272W-B hom Uncharacterized 0.392377833636474 0.347389530884866 no 1642 0.307611816392641 1054 NA Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching biological_process molecular_function cellular_component
YIL102C_p YIL102C YIL102C hom Uncharacterized 0.391635939107227 0.347663614667887 no 1643 0.335177661894191 1112 NA Putative protein of unknown function biological_process molecular_function cellular_component
YDR262W_p YDR262W YDR262W hom Uncharacterized 0.390818829173117 0.347965578018452 no 1644 0.328076351452084 1116 NA Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole and is induced in response to the DNA-damaging agent MMS; gene expression increases in response to Zymoliase treatment biological_process molecular_function fungal-type vacuole
YNL275W YNL275W BOR1 hom Verified 0.390303368400871 0.348156116404439 no 1645 0.339684594753396 1124 NA FT PROTEIN LOCALIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS|VACUOLAR TRANSPORT PLASMA MEMBRANE Boron efflux transporter of the plasma membrane; binds HCO3-, I-, Br-, NO3- and Cl-; has similarity to the characterized boron efflux transporter A. thaliana BOR1 borate transport|protein targeting to vacuole borate efflux transmembrane transporter activity integral to membrane|plasma membrane|fungal-type vacuole
YNL052W YNL052W COX5A hom Verified 0.389740170096755 0.348364344638866 no 1646 0.334863858313551 1116 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Subunit Va of cytochrome c oxidase; cytochrome c oxidase is the terminal member of the mitochondrial inner membrane electron transport chain; Cox5Ap is predominantly expressed during aerobic growth while its isoform Vb (Cox5Bp) is expressed during anaerobic growth; COX5A has a paralog, COX5B, that arose from the whole genome duplication mitochondrial electron transport, cytochrome c to oxygen cytochrome-c oxidase activity mitochondrion|integral to membrane|mitochondrial respiratory chain complex IV
YIR021W-A_p YIR021W-A YIR021W-A hom Uncharacterized 0.388881497855414 0.348681904795083 no 1647 0.350592423140237 1185 NA Putative protein of unknown function; identified by expression profiling and mass spectrometry biological_process molecular_function cellular_component
YHL005C_d YHL005C YHL005C hom Dubious 0.388528537955911 0.348812469655536 no 1648 0.335659640354113 1139 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YHL004W Unknown Unknown Unknown
YOL042W YOL042W NGL1 hom Verified 0.387940905473108 0.349029882939854 no 1649 0.342178876164568 1141 NA FT MITOCHONDRION Putative endonuclease, has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process endonuclease activity mitochondrion
YJL188C_d YJL188C BUD19 hom Dubious 0.387290970154428 0.349270404863122 no 1650 0.309612768882484 1038 NA Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 88% of ORF overlaps the verified gene RPL39; diploid mutant displays a weak budding pattern phenotype in a systematic assay Unknown Unknown Unknown
YFR016C YFR016C YFR016C hom Verified 0.387259423089677 0.349282081044389 no 1651 0.320070322563202 1087 NA Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and bud; interacts with Spa2p; YFL016C is not an essential gene biological_process molecular_function cellular bud|cytoplasm
YIL028W_d YIL028W YIL028W hom Dubious 0.38624627190384 0.349657143772392 no 1652 0.348780460428762 1163 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YNL004W YNL004W HRB1 hom Verified 0.38617798230953 0.349682429471046 no 1653 0.365372692809969 1211 NA FT RNA LOCALIZATION NUCLEUS Poly(A+) RNA-binding protein; involved in the export of mRNAs from the nucleus to the cytoplasm; similar to Npl3p; HRB1 has a paralog, GBP2, that arose from the whole genome duplication poly(A)+ mRNA export from nucleus RNA binding integral to membrane|nucleus|cytoplasm
YER087W YER087W AIM10 hom Verified 0.384665190181539 0.350242744288483 no 1654 0.361515524167956 1226 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION MITOCHONDRION Protein with similarity to tRNA synthetases; non-tagged protein is detected in purified mitochondria; null mutant is viable and displays elevated frequency of mitochondrial genome loss biological_process proline-tRNA ligase activity mitochondrion
YBL031W YBL031W SHE1 hom Verified 0.383605180069112 0.350635550045899 no 1655 0.360230669524093 1190 NA FT CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION NUCLEUS|SITE OF POLARIZED GROWTH|CYTOSKELETON Mitotic spindle protein; interacts with components of the Dam1 (DASH) complex, its effector Sli15p, and microtubule-associated protein Bim1p; also localizes to nuclear microtubules and to the bud neck in a ring-shaped structure; inhibits dynein function mitotic spindle elongation molecular_function microtubule cytoskeleton|nuclear microtubule|cellular bud neck|astral microtubule|spindle
YGL078C YGL078C DBP3 hom Verified 0.383380256328804 0.350718920130345 no 1656 0.355331705745871 1204 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS RNA-Dependent ATPase, member of DExD/H-box family; involved in cleavage of site A3 within the ITS1 spacer during rRNA processing; not essential for growth, but deletion causes severe slow-growth phenotype endonucleolytic cleavage in ITS1 upstream of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) RNA-dependent ATPase activity nucleolus|preribosome, large subunit precursor
YDR500C YDR500C RPL37B hom Verified 0.382876888605964 0.35090552411993 no 1657 0.316190372888255 1061 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L37B; protein abundance increases in response to DNA replication stress; homologous to mammalian ribosomal protein L37, no bacterial homolog; RPL37B has a paralog, RPL37A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YEL040W YEL040W UTR2 hom Verified 0.382654823885417 0.350987857407166 no 1658 0.342909279046569 1165 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM SITE OF POLARIZED GROWTH|CYTOSKELETON Chitin transglycosylase that functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar to and functionally redundant with Crh1; glycosylphosphatidylinositol (GPI)-anchored protein localized to bud neck cell wall chitin metabolic process|fungal-type cell wall organization transferase activity, transferring glycosyl groups cellular bud neck septin ring|fungal-type cell wall
YML102W YML102W CAC2 hom Verified 0.381245372093263 0.351510592366292 no 1659 0.35309071261576 1177 NA FT CHROMATIN ORGANIZATION NUCLEUS|CHROMOSOME Subunit of chromatin assembly factor I (CAF-1), with Rlf2p and Msi1p; chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of the DNA damage checkpoint after DNA repair; and chromatin dynamics during transcription DNA replication-dependent nucleosome assembly histone binding chromosome, centromeric region|CAF-1 complex
YDL073W_p YDL073W YDL073W hom Uncharacterized 0.380615192853733 0.351744403062809 no 1660 0.377819574548212 1300 NA Putative protein of unknown function; YDL073W is not an essential gene biological_process molecular_function cellular_component
YDR080W YDR080W VPS41 hom Verified 0.380106203260146 0.351933290619293 no 1661 0.352072326711155 1188 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|VACUOLAR PROTEIN PROCESSING Vacuolar membrane protein that is a subunit of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex; essential for membrane docking and fusion at the Golgi-to-endosome and endosome-to-vacuole stages of protein transport regulation of SNARE complex assembly|regulation of vacuole fusion, non-autophagic|piecemeal microautophagy of nucleus|vacuole organization|vesicle-mediated transport|protein transport|vacuole fusion, non-autophagic|vacuolar protein processing Rab guanyl-nucleotide exchange factor activity|phosphatidylinositol binding endosome|fungal-type vacuole membrane|HOPS complex
YER004W YER004W FMP52 hom Verified 0.379819747766267 0.352039611182572 no 1662 0.364003513149887 1180 NA FT ENDOPLASMIC RETICULUM|MITOCHONDRION Protein of unknown function, localized to the mitochondrial outer membrane; induced by treatment with 8-methoxypsoralen and UVA irradiation biological_process molecular_function mitochondrial outer membrane|mitochondrion|endoplasmic reticulum
YLR187W YLR187W SKG3 hom Verified 0.379452827546211 0.352175813859365 no 1663 0.353001605184125 1156 NA FT SITE OF POLARIZED GROWTH|PLASMA MEMBRANE Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; potential Cdc28p substrate; similar to Skg4p; relocalizes from bud neck to cytoplasm upon DNA replication stress; SKG3 has a paralog, CAF120, that arose from the whole genome duplication biological_process molecular_function cellular bud|cellular bud neck|cytoplasm
YPL055C YPL055C LGE1 hom Verified 0.37791538816798 0.352746725313331 no 1664 0.375951573926312 1260 NA FT CHROMATIN ORGANIZATION NUCLEUS Protein of unknown function; null mutant forms abnormally large cells, and homozygous diploid null mutant displays delayed premeiotic DNA synthesis and reduced efficiency of meiotic nuclear division histone methylation|protein monoubiquitination|regulation of cell size|histone ubiquitination|premeiotic DNA replication molecular_function nucleus
YPR194C YPR194C OPT2 hom Verified 0.377269465337357 0.352986680808879 no 1665 0.341517542911314 1146 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION PLASMA MEMBRANE Oligopeptide transporter; member of the OPT family, with potential orthologs in S. pombe and C. albicans; also plays a role in formation of mature vacuoles oligopeptide transport|vacuole fusion, non-autophagic oligopeptide transporter activity integral to membrane|integral to plasma membrane
YDR281C YDR281C PHM6 hom Verified 0.377097415592275 0.353050605867771 no 1666 0.365629220694644 1232 NA Protein of unknown function, expression is regulated by phosphate levels biological_process molecular_function fungal-type vacuole
YOR304W YOR304W ISW2 hom Verified 0.376409445133119 0.353306262630938 no 1667 0.337339741939816 1144 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS ATP-dependent DNA translocase involved in chromatin remodeling; ATPase component that, with Itc1p, forms a complex required for repression of a-specific genes, INO1, and early meiotic genes during mitotic growth negative regulation of transcription from RNA polymerase II promoter by pheromones|nucleosome positioning|termination of RNA polymerase II transcription|negative regulation of antisense RNA transcription|chromatin silencing at rDNA|chromatin remodeling|chromatin silencing at telomere single-stranded DNA binding|DNA translocase activity chromatin accessibility complex|nucleus
YHR198C YHR198C AIM18 hom Verified 0.376197731658945 0.353384950821949 no 1668 0.351354590057517 1207 NA FT KETONE METABOLISM|AMINO ACID METABOLISM MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss biological_process molecular_function mitochondrion
YDR241W_d YDR241W BUD26 hom Dubious 0.376003698215713 0.353457073326376 no 1669 0.359236187937832 1192 NA Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 1% of ORF overlaps the verified gene SNU56; diploid mutant displays a weak budding pattern phenotype in a systematic assay Unknown Unknown Unknown
YFR033C YFR033C QCR6 hom Verified 0.375957075524051 0.353474403830781 no 1670 0.362293687921556 1197 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Subunit 6 of the ubiquinol cytochrome-c reductase complex; the complex, also known as the cytochrome bc(1) complex or Complex III, is a component of the mitochondrial inner membrane electron transport chain; highly acidic protein; required for maturation of cytochrome c1; may be loosely associated with the complex since it is easily released into the intermembrane space mitochondrial electron transport, ubiquinol to cytochrome c|aerobic respiration ubiquinol-cytochrome-c reductase activity mitochondrion|integral to membrane|mitochondrial respiratory chain complex III
YPR067W YPR067W ISA2 hom Verified 0.375320101979353 0.353711208921612 no 1671 0.380466658281692 1271 NA FT KETONE METABOLISM|COFACTOR METABOLISM MITOCHONDRION Protein required for maturation of mitochondrial [4Fe-4S] proteins; functions in a complex with Isa1p and possibly Iba57p; localizes to the mitochondrial intermembrane space, overexpression of ISA2 suppresses grx5 mutations iron-sulfur cluster assembly|biotin biosynthetic process iron ion binding mitochondrion|mitochondrial intermembrane space
YOR302W YOR302W YOR302W hom Verified 0.374658617961217 0.353957186100851 no 1672 0.34450801080579 1158 NA FT TRANSLATION CPA1 uORF, Arginine attenuator peptide, regulates translation of the CPA1 mRNA regulation of translation translation regulator activity cytosol
YPR100W YPR100W MRPL51 hom Verified 0.37435290112567 0.354070889521024 no 1673 0.377045922668974 1251 NA FT TRANSLATION|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit mitochondrial translation|aerobic respiration structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YMR219W YMR219W ESC1 hom Verified 0.374089061357446 0.354169028318088 no 1674 0.36950931668432 1255 NA FT GENE SILENCING NUCLEUS Protein localized to the nuclear periphery, involved in telomeric silencing; interacts with PAD4-domain of Sir4p chromatin silencing at telomere molecular_function nuclear periphery
YJL190C YJL190C RPS22A hom Verified 0.37371120788408 0.354309592935045 no 1675 0.35280424565509 1173 NA FT TRANSLATION RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22A has a paralog, RPS22B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic small ribosomal subunit
YMR304C-A_d YMR304C-A YMR304C-A hom Dubious 0.372796379686938 0.354649998765383 no 1676 0.355598253638166 1187 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene SCW10 Unknown Unknown Unknown
YML101C YML101C CUE4 hom Verified 0.371474552593682 0.355142053136883 no 1677 0.294178256594413 980 NA FT ENDOPLASMIC RETICULUM Protein of unknown function; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination; CUE4 has a paralog, CUE1, that arose from the whole genome duplication biological_process molecular_function endoplasmic reticulum|cytoplasm
YGL049C YGL049C TIF4632 hom Verified 0.371217857036638 0.355237636926621 no 1678 0.339961254258311 1143 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION RIBOSOME Translation initiation factor eIF4G, subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); associates with the poly(A)-binding protein Pab1p, also interacts with eIF4A (Tif1p); TIF4632 has a paralog, TIF4631, that arose from the whole genome duplication translational initiation|stress granule assembly translation initiation factor binding|mRNA binding|translation initiation factor activity eukaryotic translation initiation factor 4F complex|cytoplasmic stress granule
YLR269C_d YLR269C YLR269C hom Dubious 0.371111905830482 0.355277091834638 no 1679 0.342161231829886 1137 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YDR485C YDR485C VPS72 hom Verified 0.370218763160723 0.355609748650547 no 1680 0.396581319810713 1312 NA FF|FT CHROMATIN ORGANIZATION NUCLEUS|CHROMOSOME Htz1p-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting chromatin remodeling|histone exchange histone binding Swr1 complex|nucleus|cytoplasm
YNL318C YNL318C HXT14 hom Verified 0.370086321086633 0.355659086937295 no 1681 0.332814797798019 1098 NA FT MITOCHONDRION|PLASMA MEMBRANE Protein with similarity to hexose transporter family members, expression is induced in low glucose and repressed in high glucose; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies hexose transport galactose transmembrane transporter activity mitochondrion|integral to membrane|plasma membrane
YGL152C_d YGL152C YGL152C hom Dubious 0.369847820201979 0.355747941123386 no 1682 0.368474289507878 1242 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF PEX14/YGL153W Unknown Unknown Unknown
YMR173W-A_d YMR173W-A YMR173W-A hom Dubious 0.369552421692728 0.355858003547578 no 1683 0.368723807447491 1219 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene DDR48/YML173W Unknown Unknown Unknown
YPR093C YPR093C ASR1 hom Verified 0.369260235114808 0.355966881059845 no 1684 0.358917538876156 1206 NA FT NUCLEUS Ubiquitin ligase that modifies and regulates RNA Pol II; involved in a putative alcohol-responsive signaling pathway; accumulates in the nucleus under alcohol stress; contains a Ring/PHD finger domain similar to the mammalian rA9 protein response to ethanol|protein ubiquitination ubiquitin-protein ligase activity nucleus|cytoplasm
YOR243C YOR243C PUS7 hom Verified 0.367629670363593 0.3565746940401 no 1685 0.374023015288079 1251 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Pseudouridine synthase, catalyzes pseudouridylation at positions 35 and 56 in U2 snRNA, position 50 in 5S rRNA, position 13 in cytoplasmic tRNAs, and position 35 in pre-tRNA(Tyr); conserved in archaea, vertebrates, and some bacteria snRNA pseudouridine synthesis|tRNA pseudouridine synthesis|enzyme-directed rRNA pseudouridine synthesis pseudouridine synthase activity nucleus
YOR032C YOR032C HMS1 hom Verified 0.367259527143793 0.356712720265546 no 1686 0.364776958243542 1241 NA FT NUCLEUS Basic helix-loop-helix (bHLH) protein with similarity to myc-family transcription factors; overexpression confers hyperfilamentous growth and suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant pseudohyphal growth sequence-specific DNA binding transcription factor activity cellular_component
YGL101W_p YGL101W YGL101W hom Uncharacterized 0.366214017007267 0.357102691785847 no 1687 0.355748297123805 1171 NA FT NUCLEUS Putative protein of unknown function; non-essential gene with similarity to YBR242W; interacts with the DNA helicase Hpr5p biological_process molecular_function nucleus|cytoplasm
YDL144C YDL144C YDL144C hom Verified 0.365770655879601 0.35726810900596 no 1688 0.355486142359964 1189 NA FT OXIDATION-REDUCTION PROCESS NUCLEUS Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YDL144C is not an essential gene; protein abundance increases in response to DNA replication stress biological_process molecular_function nucleus|cytoplasm
YGR017W_p YGR017W YGR017W hom Uncharacterized 0.365067399361619 0.357530547732417 no 1689 0.337108824749974 1117 NA FT OXIDATION-REDUCTION PROCESS NUCLEUS Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm biological_process molecular_function nucleus|cytoplasm
YGL222C YGL222C EDC1 hom Verified 0.365010672512611 0.357551719791486 no 1690 0.351128419848548 1183 NA FT RNA PROCESSING|TRANSLATION NUCLEUS RNA-binding protein that activates mRNA decapping directly; binds to the mRNA substrate and enhances the activity of the decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress deadenylation-dependent decapping of nuclear-transcribed mRNA|positive regulation of translation in response to stress mRNA binding nucleus|cytoplasm
YPL193W YPL193W RSA1 hom Verified 0.363942363249249 0.357950524725257 no 1691 0.383573195659013 1291 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS NUCLEUS Protein involved in the assembly of 60S ribosomal subunits; functionally interacts with Dbp6p; functions in a late nucleoplasmic step of the assembly ribosomal large subunit assembly molecular_function nucleoplasm
YLR052W YLR052W IES3 hom Verified 0.363638591592688 0.358063952466956 no 1692 0.348057887935072 1167 NA FT CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS|CHROMOSOME Subunit of the INO80 chromatin remodeling complex nucleosome mobilization|telomere maintenance|chromatin silencing at telomere molecular_function nucleus|Ino80 complex
YCL009C YCL009C ILV6 hom Verified 0.362869409342904 0.358351219625337 no 1693 0.349417515810511 1144 NA FT KETONE METABOLISM|AMINO ACID METABOLISM MITOCHONDRION Regulatory subunit of acetolactate synthase, which catalyzes the first step of branched-chain amino acid biosynthesis; enhances activity of the Ilv2p catalytic subunit, localizes to mitochondria branched-chain amino acid biosynthetic process enzyme regulator activity|acetolactate synthase activity mitochondrial nucleoid|acetolactate synthase complex|mitochondrion
YPR170C_d YPR170C YPR170C hom Dubious 0.362788961593213 0.358381269150496 no 1694 0.412066605111857 1328 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORFs YPR169W-A and YPR170W-B Unknown Unknown Unknown
YLR185W YLR185W RPL37A hom Verified 0.360376252875698 0.359282891372332 no 1695 0.348859778299926 1161 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L37A; homologous to mammalian ribosomal protein L37, no bacterial homolog; RPL37A has a paralog, RPL37B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YKR003W YKR003W OSH6 hom Verified 0.36005338979756 0.359403603962338 no 1696 0.335179324810736 1140 NA FT VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|MEMBRANE ORGANIZATION ENDOPLASMIC RETICULUM|PLASMA MEMBRANE Member of an oxysterol-binding protein family; overlapping, redundant functions in sterol metabolism and which collectively perform a function essential for viability; GFP-fusion protein localizes to the cell periphery; overexpression extends lifespan by promoting vacuolar fusion sterol homeostasis|maintenance of cell polarity|endocytosis|sterol transport|exocytosis|sterol metabolic process phosphatidic acid binding|lipid binding|phosphatidylinositol-3,4-bisphosphate binding|oxysterol binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-5-phosphate binding|phosphatidylinositol-4-phosphate binding cortical endoplasmic reticulum|extrinsic to membrane|cytoplasm
YGR072W YGR072W UPF3 hom Verified 0.35998951824301 0.359427486029505 no 1697 0.353417409932958 1197 NA FT NUCLEUS Component of the nonsense-mediated mRNA decay (NMD) pathway, along with Nam7p and Nmd2p; involved in decay of mRNA containing nonsense codons; involved in telomere maintenance nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay|translational frameshifting|protein ubiquitination molecular_function nucleolus|nucleus|polysome|cytoplasm
YMR082C_d YMR082C YMR082C hom Dubious 0.358989039820054 0.359801644246159 no 1698 0.37491053458143 1237 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YLL028W YLL028W TPO1 hom Verified 0.357037896617184 0.360531717768384 no 1699 0.31994348407306 1046 NA FT PLASMA MEMBRANE Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; recognizes spermine, putrescine, and spermidine; catalyzes uptake of polyamines at alkaline pH and excretion at acidic pH; phosphorylation enhances activity and sorting to the plasma membrane spermidine transport|putrescine transport|spermine transport spermidine transmembrane transporter activity|spermine transmembrane transporter activity fungal-type vacuole membrane|integral to membrane|cellular bud membrane|plasma membrane
YJL206C_p YJL206C YJL206C hom Uncharacterized 0.356324876821449 0.360798640661409 no 1700 0.355949733763657 1224 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Putative protein of unknown function; similar to transcriptional regulators from the Zn[2]-Cys[6] binuclear cluster protein family; mRNA is weakly cell cycle regulated, peaking in S phase; induced rapidly upon MMS treatment biological_process molecular_function cellular_component
YBR179C YBR179C FZO1 hom Verified 0.355978923320075 0.360928174707584 no 1701 0.365084745819095 1184 NA FT MEMBRANE ORGANIZATION|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitofusin; integral membrane protein involved in mitochondrial outer membrane tethering and fusion; role in mitochondrial genome maintenance; efficient tethering and degradation of Fzo1p requires an intact N-terminal GTPase domain; targeted for destruction by the ubiquitin ligase SCF-Mdm30p and the cytosolic ubiquitin-proteasome system mitochondrial fusion GTPase activity|protein homodimerization activity mitochondrial outer membrane|mitochondrion|mitochondrial inner membrane|integral to mitochondrial outer membrane
YNL217W_p YNL217W YNL217W hom Uncharacterized 0.354744582897032 0.361390473981095 no 1702 0.356836890507562 1171 NA Putative protein of unknown function; weak sequence similarity to bis (5'-nucleotidyl)-tetraphosphatases; (GFP)-fusion protein localizes to the vacuole; null mutant is highly sensitive to azaserine and resistant to sodium-O-vandate biological_process phosphatase activity fungal-type vacuole
YNL179C_d YNL179C YNL179C hom Dubious 0.354634420556719 0.361431743089679 no 1703 0.360892279105121 1222 NA Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; deletion in cyr1 mutant results in loss of stress resistance Unknown Unknown Unknown
YDR298C YDR298C ATP5 hom Verified 0.353310468077141 0.361927849282153 no 1704 0.367901791568076 1231 NA FT ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS MITOCHONDRION Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase, which is an evolutionarily conserved enzyme complex required for ATP synthesis; homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein); phosphorylated ATP synthesis coupled proton transport hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism mitochondrion|integral to membrane|mitochondrial proton-transporting ATP synthase, stator stalk|mitochondrial proton-transporting ATP synthase complex
YJL132W_p YJL132W YJL132W hom Uncharacterized 0.353187148811662 0.361974070814271 no 1705 0.366049616140543 1216 NA Putative protein of unknown function; localizes to the membrane fraction; possible Zap1p-regulated target gene induced by zinc deficiency; YJL132W is a non-essential gene biological_process molecular_function membrane
YJR054W YJR054W KCH1 hom Verified 0.351603464337716 0.362567833372611 no 1706 0.353838748681031 1179 NA Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate biological_process molecular_function integral to membrane|fungal-type vacuole
YFL004W YFL004W VTC2 hom Verified 0.351481353438097 0.362613629525005 no 1707 0.358470715856324 1219 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT ENDOPLASMIC RETICULUM Subunit of the vacuolar transporter chaperone (VTC) complex involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion polyphosphate metabolic process|vacuolar transport|microautophagy|protein localization|vacuole fusion, non-autophagic molecular_function fungal-type vacuole membrane|integral to membrane|endoplasmic reticulum|vacuolar transporter chaperone complex
YPR074C YPR074C TKL1 hom Verified 0.351428206052897 0.362633562395298 no 1708 0.399242973702092 1307 NA FF|FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS Transketolase; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids; TKL1 has a paralog, TKL2, that arose from the whole genome duplication pentose-phosphate shunt transketolase activity cytoplasm
YMR242C YMR242C RPL20A hom Verified 0.35136860233926 0.362655917147589 no 1709 0.345363140514863 1168 NA FF|FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L20A; homologous to mammalian ribosomal protein L18A, no bacterial homolog; RPL20A has a paralog, RPL20B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YGL037C YGL037C PNC1 hom Verified 0.346984664588542 0.364301419885556 no 1710 0.348056307786586 1156 NA FT NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|GENE SILENCING NUCLEUS Nicotinamidase that converts nicotinamide to nicotinic acid; part of the NAD(+) salvage pathway; required for life span extension by calorie restriction; PNC1 expression responds to all known stimuli that extend replicative life span; protein increases in abundance and relative distribution to cytoplasmic foci decreases upon DNA replication stress replicative cell aging|chromatin silencing at rDNA|nicotinate nucleotide salvage|chromatin silencing at telomere nicotinamidase activity nucleus|peroxisome|cytoplasm
YDR502C YDR502C SAM2 hom Verified 0.346924419332575 0.364324050340651 no 1711 0.349318768235272 1164 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM S-adenosylmethionine synthetase; catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; SAM2 has a paralog, SAM1, that arose from the whole genome duplication methionine metabolic process|S-adenosylmethionine biosynthetic process methionine adenosyltransferase activity cellular_component
YBL051C YBL051C PIN4 hom Verified 0.346771962513026 0.364381321148806 no 1712 0.373990727171265 1260 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE Protein involved in G2/M phase progression and response to DNA damage, interacts with Rad53p; contains an RNA recognition motif, a nuclear localization signal, and several SQ/TQ cluster domains; hyperphosphorylated in response to DNA damage G2/M transition of mitotic cell cycle|DNA damage checkpoint molecular_function cytoplasm
YML118W YML118W NGL3 hom Verified 0.346255200847303 0.364575466555886 no 1713 0.338447836506931 1123 NA 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication polyadenylation-dependent RNA catabolic process poly(A)-specific ribonuclease activity|endonuclease activity cellular_component
YGL126W YGL126W SCS3 hom Verified 0.346022462305657 0.364662916897171 no 1714 0.370915084105958 1238 NA FT LIPID METABOLISM ENDOPLASMIC RETICULUM Protein required for inositol prototrophy; required for normal ER membrane biosynthesis; ortholog of the FIT family of proteins involved in triglyceride droplet biosynthesis and homologous to human FIT2; disputed role in the synthesis of inositol phospholipids from inositol phospholipid metabolic process molecular_function integral to membrane|endoplasmic reticulum
YLL051C YLL051C FRE6 hom Verified 0.345713111490986 0.364779164817626 no 1715 0.342005006357654 1167 NA FT ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|GEN. OF PRECURSOR METABOLITES AND ENERGY Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels intracellular sequestering of iron ion|copper ion import ferric-chelate reductase activity fungal-type vacuole membrane|integral to membrane|fungal-type vacuole
YDL046W YDL046W NPC2 hom Verified 0.343765863811578 0.36551118704479 no 1716 0.357343306556284 1180 NA Functional homolog of human NPC2/He1, which is a cholesterol-binding protein whose deficiency causes Niemann-Pick type C2 disease involving retention of cholesterol in lysosomes intracellular sterol transport molecular_function fungal-type vacuole lumen|fungal-type vacuole
YBR191W YBR191W RPL21A hom Verified 0.343276666922771 0.365695166311836 no 1717 0.37019852518735 1224 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L21A; homologous to mammalian ribosomal protein L21, no bacterial homolog; RPL21A has a paralog, RPL21B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YDR056C_p YDR056C YDR056C hom Uncharacterized 0.34264702978628 0.365932008421963 no 1718 0.359364299177111 1192 NA FT ENDOPLASMIC RETICULUM Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDR056C is not an essential protein biological_process molecular_function endoplasmic reticulum
YEL053C YEL053C MAK10 hom Verified 0.342387080881582 0.366029804804602 no 1719 0.36487954716894 1215 NA Non-catalytic subunit of N-terminal acetyltransferase of the NatC type, required for replication of dsRNA virus; expression is glucose-repressible N-terminal protein amino acid acetylation peptide alpha-N-acetyltransferase activity NatC complex|cytoplasm
YJL024C YJL024C APS3 hom Verified 0.341875458865048 0.366222309521674 no 1720 0.378120124461392 1251 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Small subunit of the clathrin-associated adaptor complex AP-3; involved in vacuolar protein sorting; related to the sigma subunit of the mammalian clathrin AP-3 complex; suppressor of loss of casein kinase 1 function; protein abundance increases in response to DNA replication stress Golgi to vacuole transport|vesicle-mediated transport molecular_function AP-3 adaptor complex
YDR097C YDR097C MSH6 hom Verified 0.341473860525129 0.366373439932059 no 1721 0.350379073879959 1164 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME Protein required for mismatch repair in mitosis and meiosis, forms a complex with Msh2p to repair both single-base & insertion-deletion mispairs; also involved in interstrand cross-link repair; potentially phosphorylated by Cdc28p mismatch repair|meiotic mismatch repair guanine/thymine mispair binding|four-way junction DNA binding|ATPase activity|single base insertion or deletion binding|ATP binding MutSalpha complex|nucleus
YDR020C_p YDR020C DAS2 hom Uncharacterized 0.340248523776773 0.366834689480869 no 1722 0.347211557286929 1159 NA FT NUCLEOTIDE METABOLISM NUCLEUS Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; weak similarity with uridine kinases and with phosphoribokinases biological_process molecular_function nucleus|cytoplasm
YDR462W YDR462W MRPL28 hom Verified 0.338795958325374 0.367381723100207 no 1723 0.367044229407665 1215 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YCR068W YCR068W ATG15 hom Verified 0.33848594464621 0.367498508614248 no 1724 0.383338638164816 1260 NA FT LIPID METABOLISM|MEMBRANE ORGANIZATION|VACUOLAR PROTEIN PROCESSING ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS Lipase required for intravacuolar lysis of autophagic bodies and Cvt bodies; targeted to intravacuolar vesicles during autophagy via the multivesicular body (MVB) pathway membrane disassembly|autophagy|piecemeal microautophagy of nucleus|vacuolar protein processing|multivesicular body membrane disassembly lipase activity integral to membrane|vacuolar lumen
YHR123W YHR123W EPT1 hom Verified 0.338471053948388 0.367504118410108 no 1725 0.321177179132893 1092 NA FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferase; not essential for viability; EPT1 has a paralog, CPT1, that arose from the whole genome duplication phosphatidylethanolamine biosynthetic process|phosphatidylcholine biosynthetic process ethanolaminephosphotransferase activity|diacylglycerol cholinephosphotransferase activity integral to membrane|Golgi apparatus
YOR349W YOR349W CIN1 hom Verified 0.337071625925832 0.368031453152799 no 1726 0.371887644745306 1240 NA FF|FT PROTEIN COMPLEX ORG/BIOGENESIS Tubulin folding factor D involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl protein folding|tubulin complex assembly|tubulin complex biogenesis beta-tubulin binding cellular_component
YPL206C YPL206C PGC1 hom Verified 0.336306520078042 0.368319866840933 no 1727 0.33639461733291 1139 NA FT LIPID METABOLISM|CARBOHYDRATE METABOLISM MITOCHONDRION Phosphatidyl Glycerol phospholipase C; regulates the phosphatidylglycerol (PG) content via a phospholipase C-type degradation mechanism; contains glycerophosphodiester phosphodiesterase motifs glycerophospholipid catabolic process|phosphatidylglycerol catabolic process phosphatidylglycerol phospholipase C activity mitochondrion|lipid particle
YNL254C YNL254C RTC4 hom Verified 0.336191375633119 0.368363278027889 no 1728 0.345031931822908 1132 NA FT NUCLEUS Protein of unknown function; null mutation suppresses cdc13-1 temperature sensitivity; (GFP)-fusion protein localizes to both the cytoplasm and the nucleus biological_process molecular_function nucleus|cytoplasm
YPL089C YPL089C RLM1 hom Verified 0.335391950614136 0.368664719587622 no 1729 0.406239356288362 1342 NA FT TRANSCRIPTION FROM RNA POL II|SIGNALING NUCLEUS MADS-box transcription factor; component of the protein kinase C-mediated MAP kinase pathway involved in the maintenance of cell integrity; phosphorylated and activated by the MAP-kinase Slt2p; RLM1 has a paralog, SMP1, that arose from the whole genome duplication signal transduction|positive regulation of transcription from RNA polymerase II promoter in response to stress|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity|DNA binding, bending|sequence-specific DNA binding nucleus
YDR386W YDR386W MUS81 hom Verified 0.334919123207637 0.368843048072872 no 1730 0.41747858831825 1378 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION NUCLEUS Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in DNA repair, replication fork stability, and joint molecule formation/resolution during meiotic recombination; helix-hairpin-helix protein; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates the function of Mms4p-Mus81p DNA repair|DNA topological change|reciprocal meiotic recombination|resolution of meiotic recombination intermediates|response to DNA damage stimulus crossover junction endodeoxyribonuclease activity|endonuclease activity Holliday junction resolvase complex|nucleus
YJR127C YJR127C RSF2 hom Verified 0.33204036081601 0.369929391352936 no 1731 0.333770003730899 1120 NA FT NUCLEUS Zinc-finger protein; involved in transcriptional control of both nuclear and mitochondrial genes, many of which specify products required for glycerol-based growth, respiration, and other functions; RSF2 has a paralog, TDA9, that arose from the whole genome duplication; relocalizes from nucleus to cytoplasm upon DNA replication stress regulation of transcription, DNA-dependent sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity nucleus
YKR084C YKR084C HBS1 hom Verified 0.331173373910112 0.37025676551903 no 1732 0.377514843688073 1248 NA FT TRANSLATION|NUCLEOTIDE METABOLISM GTPase with similarity to translation release factors; together with binding partner Dom34p, facilitates ribosomal subunit dissociation and peptidyl-tRNA release when translation is stalled; genetically implicated in mRNA no-go decay nuclear-transcribed mRNA catabolic process, no-go decay|ribosome disassembly|nonfunctional rRNA decay ribosome binding|GTPase activity cytoplasm
YDR139C YDR139C RUB1 hom Verified 0.330678256231989 0.37044376409058 no 1733 0.356182994640459 1188 NA Ubiquitin-like protein with similarity to mammalian NEDD8; conjugation (neddylation) substrates include the cullins Cdc53p, Rtt101p, and Cul3p; activated by Ula1p and Uba3p (E1 enzyme pair); conjugation mediated by Ubc12p (E2 enzyme) protein neddylation protein tag cytoplasm
YNL279W YNL279W PRM1 hom Verified 0.330531053454944 0.37049936629337 no 1734 0.375937029884238 1227 NA FT MEMBRANE ORGANIZATION SITE OF POLARIZED GROWTH|PLASMA MEMBRANE Pheromone-regulated multispanning membrane protein involved in membrane fusion during mating; predicted to have 5 transmembrane segments and a coiled coil domain; localizes to the shmoo tip; regulated by Ste12p plasma membrane fusion involved in cytogamy|response to pheromone molecular_function integral to membrane|mating projection tip
YGR220C YGR220C MRPL9 hom Verified 0.330414826313054 0.370543270128661 no 1735 0.342559800581568 1162 NA FT TRANSLATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit cytoplasmic translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YHR103W YHR103W SBE22 hom Verified 0.330291717574761 0.370589775268474 no 1736 0.373164540781669 1230 NA FT PROTEIN LOCALIZATION|CELL WALL ORG/BIOGENESIS GOLGI APPARATUS Protein involved in the transport of cell wall components from the Golgi to the cell surface; similar in structure and functionally redundant with Sbe2p; involved in bud growth fungal-type cell wall organization molecular_function cytoplasm
YBR101C YBR101C FES1 hom Verified 0.329254764117073 0.370981566277432 no 1737 0.37003442911491 1258 NA FT TRANSLATION RIBOSOME Hsp70 (Ssa1p) nucleotide exchange factor; cytosolic homolog of Sil1p, which is the nucleotide exchange factor for BiP (Kar2p) in the endoplasmic reticulum; protein abundance increases in response to DNA replication stress cytoplasmic translation adenyl-nucleotide exchange factor activity cytosol|cytosolic ribosome
YPL215W YPL215W CBP3 hom Verified 0.328978604131444 0.371085930082849 no 1738 0.348282951326098 1155 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex positive regulation of mitochondrial translation|mitochondrial respiratory chain complex III assembly ribosome binding integral to mitochondrial membrane|mitochondrion|mitochondrial ribosome
YOR052C YOR052C YOR052C hom Verified 0.328359020907957 0.37132011168459 no 1739 0.373344783562798 1212 NA FT NUCLEUS Nuclear protein of unknown function; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner and by weak acid; transcriptionally regulated by Rpn4p along with proteasome subunit genes; putative ortholog of human AIRAP, which stimulates proteasome activity in response to arsenic; protein abundance increases in response to DNA replication stress biological_process molecular_function nucleus
YKR045C_p YKR045C YKR045C hom Uncharacterized 0.328247040066522 0.371362441759512 no 1740 0.372385820932528 1219 NA Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm biological_process molecular_function cytoplasm
YNR059W YNR059W MNT4 hom Verified 0.327060976493509 0.371810883162062 no 1741 0.373394455775214 1245 NA FT CARBOHYDRATE METABOLISM Putative alpha-1,3-mannosyltransferase, not required for protein O-glycosylation protein O-linked glycosylation alpha-1,3-mannosyltransferase activity cellular_component
YJL192C YJL192C SOP4 hom Verified 0.326827337934327 0.371899240612698 no 1742 0.44162817016367 1459 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM ER-membrane protein; suppressor of pma1-7, deletion of SOP4 slows down the export of wild-type Pma1p and Pma1-7 from the ER ER to Golgi vesicle-mediated transport molecular_function integral to membrane|endoplasmic reticulum
YHR001W YHR001W OSH7 hom Verified 0.326668824095076 0.371959191232197 no 1743 0.358639683522731 1198 NA FT VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT ENDOPLASMIC RETICULUM Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability maintenance of cell polarity|endocytosis|exocytosis|sterol transport|sterol metabolic process|late endosome to vacuole transport lipid binding|oxysterol binding integral to membrane|cortical endoplasmic reticulum|cytoplasm
YDR107C YDR107C TMN2 hom Verified 0.326422652135882 0.372052300685452 no 1744 0.347408625315256 1143 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS|VACUOLAR TRANSPORT Protein with a role in cellular adhesion and filamentous growth; similar to Emp70p and Tmn3p; member of the evolutionarily conserved Transmembrane Nine family of proteins with nine membrane-spanning segments cellular copper ion homeostasis|pseudohyphal growth|vacuolar transport|invasive growth in response to glucose limitation molecular_function fungal-type vacuole membrane|integral to membrane
YBL001C YBL001C ECM15 hom Verified 0.324785413379307 0.372671742510701 no 1745 0.364925443939086 1207 NA FT CELL WALL ORG/BIOGENESIS NUCLEUS Non-essential protein of unknown function, likely exists as tetramer, may be regulated by the binding of small-molecule ligands (possibly sulfate ions), may have a role in yeast cell-wall biogenesis fungal-type cell wall organization molecular_function nucleus|cytoplasm
YKL207W YKL207W EMC3 hom Verified 0.324270005945476 0.372866812821399 no 1746 0.357945252606098 1191 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; required for respiratory growth; null mutant displays induction of the unfolded protein response; homologous to worm Y62E10A.10/EMC-3, fly CG6750, human TMEM111 protein folding in endoplasmic reticulum molecular_function ER membrane protein complex|integral to membrane
YIR033W YIR033W MGA2 hom Verified 0.323206108590576 0.373269577494633 no 1747 0.30400796879769 1032 NA FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|LIPID METABOLISM|GENE SILENCING ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM ER membrane protein involved in regulation of OLE1 transcription, acts with homolog Spt23p; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting positive regulation of transcription from RNA polymerase II promoter in response to hypoxia|cellular response to cold|positive regulation of unsaturated fatty acid biosynthetic process by positive regulation of transcription from RNA polymerase II promoter|mRNA stabilization|positive regulation of transcription from RNA polymerase II promoter in response to cobalt ion|positive regulation of transcription from RNA polymerase II promoter|chromatin silencing at silent mating-type cassette molecular_function integral to endoplasmic reticulum membrane|nucleus
YLR017W YLR017W MEU1 hom Verified 0.323131738799624 0.373297737204093 no 1748 0.354900234751757 1181 NA FT KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS Methylthioadenosine phosphorylase (MTAP), catalyzes the initial step in the methionine salvage pathway; affects polyamine biosynthesis through regulation of ornithine decarboxylase (Spe1p) activity; regulates ADH2 gene expression L-methionine salvage from methylthioadenosine|glutamate biosynthetic process S-methyl-5-thioadenosine phosphorylase activity|mRNA binding cytoplasm
YGL086W YGL086W MAD1 hom Verified 0.322493945918978 0.373539261718813 no 1749 0.367856004200366 1203 NA FT CELL CYCLE|CELL DIVISION ENDOMEMBRANE SYSTEM|NUCLEUS|CHROMOSOME NUCLEAR PORE|KINETOCHORE Coiled-coil protein involved in the spindle-assembly checkpoint; required for inhibition of karyopherin/importin Pse1p (aka Kap121p) upon spindle assembly checkpoint arrest; phosphorylated by Mps1p upon checkpoint activation which leads to inhibition of the activity of the anaphase promoting complex; forms a complex with Mad2p nucleocytoplasmic transport|mitotic cell cycle spindle assembly checkpoint|mitotic cell cycle G2/M transition decatenation checkpoint molecular_function nucleus|nuclear pore|kinetochore
YBL102W YBL102W SFT2 hom Verified 0.321051885853254 0.374085535595618 no 1750 0.389878974789785 1304 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Non-essential tetra-spanning membrane protein found mostly in the late Golgi, can suppress some sed5 alleles; may be part of the transport machinery, but precise function is unknown; similar to mammalian syntaxin 5 Golgi to endosome transport molecular_function integral to membrane|Golgi membrane
YIL123W YIL123W SIM1 hom Verified 0.320950401166375 0.37412398904944 no 1751 0.37355097829059 1257 NA FT CELL WALL ORG/BIOGENESIS Protein of the SUN family (Sim1p, Uth1p, Nca3p, Sun4p) that may participate in DNA replication, promoter contains SCB regulation box at -300 bp indicating that expression may be cell cycle-regulated fungal-type cell wall organization molecular_function fungal-type cell wall
YOL009C YOL009C MDM12 hom Verified 0.320261850393351 0.374384920143487 no 1752 0.376021349609781 1223 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION Mitochondrial outer membrane protein, required for transmission of mitochondria to daughter cells; component of the ERMES complex that links the ER to mitochondria; may influence import and assembly of outer membrane beta-barrel proteins mitochondrion inheritance|mitochondrion organization|protein import into mitochondrial outer membrane|phospholipid transport molecular_function mitochondrial outer membrane|mitochondrion|ERMES complex
YER010C YER010C YER010C hom Verified 0.320013371592902 0.37447909704563 no 1753 0.372901231160159 1243 NA Protein of unknown function, forms a ring-shaped homotrimer; has similarity to members of the prokaryotic rraA family; possibly involved in a phosphotransfer reaction biological_process molecular_function cellular_component
YOR339C YOR339C UBC11 hom Verified 0.31961507581269 0.374630072276239 no 1754 0.365616576196362 1192 NA Ubiquitin-conjugating enzyme most similar in sequence to Xenopus ubiquitin-conjugating enzyme E2-C, but not a true functional homolog of this E2; unlike E2-C, not required for the degradation of mitotic cyclin Clb2 protein polyubiquitination|protein monoubiquitination ubiquitin-protein ligase activity cytoplasm
YOR113W YOR113W AZF1 hom Verified 0.319409097845727 0.374708156394511 no 1755 0.395478585377867 1317 NA FT TRANSCRIPTION FROM RNA POL II|CELL WALL ORG/BIOGENESIS NUCLEUS Zinc-finger transcription factor; in the presence of glucose, activates transcription of genes involved in growth and carbon metabolism; in nonfermentable carbon sources, activates transcription of genes involved in maintenance of cell wall integrity regulation of fungal-type cell wall organization|regulation of transcription from RNA polymerase II promoter|cellular response to carbohydrate stimulus RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus
YFR009W YFR009W GCN20 hom Verified 0.319260949051253 0.374764321247755 no 1756 0.398372333704401 1327 NA FF|FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|NUCLEOTIDE METABOLISM RIBOSOME Positive regulator of the Gcn2p kinase activity, forms a complex with Gcn1p; proposed to stimulate Gcn2p activation by an uncharged tRNA regulation of translational elongation ATPase activity cytosol|cytosolic ribosome
YGL076C YGL076C RPL7A hom Verified 0.318990795515162 0.374866746291697 no 1757 0.350878007978411 1180 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L7A; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2); homologous to mammalian ribosomal protein L7 and bacterial L30; RPL7A has a paralog, RPL7B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit|cytoplasm
YPR091C YPR091C NVJ2 hom Verified 0.318933577809432 0.37488844074066 no 1758 0.361680889851549 1199 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Lipid-binding ER protein, enriched at nucleus-vacuolar junctions (NVJ); may be involved in sterol metabolism or signaling at the NVJ; contains a synaptotagmin-like-mitochondrial- lipid binding protein (SMP) domain; binds phosphatidylinositols and other lipids in a large-scale study; may interact with ribosomes, based on co-purification experiments biological_process lipid binding ribosome|nucleus-vacuole junction|endoplasmic reticulum
YGR232W YGR232W NAS6 hom Verified 0.318691748336832 0.374980136260983 no 1759 0.377723554550407 1266 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS NUCLEUS Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); ortholog of human oncoprotein gankyrin, which interacts with the Rb tumor suppressor and CDK4/6 proteolysis|proteasome regulatory particle assembly molecular_function cytosol|nucleus|proteasome regulatory particle
YDR520C_p YDR520C URC2 hom Uncharacterized 0.318021498101787 0.375234314845343 no 1760 0.405495942013039 1334 NA FT TRANSCRIPTION FROM RNA POL II|NUCLEOTIDE METABOLISM NUCLEUS Putative Zn(II)2Cys6 motif containing transcription factor; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; similar to S. kluyveri Urc2p involved in uracil catabolism uracil catabolic process sequence-specific DNA binding nucleus|cytoplasm
YNL278W YNL278W CAF120 hom Verified 0.317768717064751 0.375330190919411 no 1761 0.364453259842124 1192 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS|SITE OF POLARIZED GROWTH Part of the CCR4-NOT transcriptional regulatory complex; involved in controlling mRNA initiation, elongation, and degradation; CAF120 has a paralog, SKG3, that arose from the whole genome duplication regulation of transcription from RNA polymerase II promoter molecular_function CCR4-NOT complex
YJL037W YJL037W IRC18 hom Verified 0.31733048803322 0.375496422895858 no 1762 0.381089199813784 1282 NA Putative protein of unknown function; expression induced in respiratory-deficient cells and in carbon-limited chemostat cultures; similar to adjacent ORF, YJL038C; null mutant displays increased levels of spontaneous Rad52p foci biological_process molecular_function cellular_component
YFL010W-A YFL010W-A AUA1 hom Verified 0.315935527852109 0.376025722331605 no 1763 0.386717621905923 1267 NA Protein required for the negative regulation by ammonia of Gap1p, which is a general amino acid permease amino acid transport molecular_function cellular_component
YBR235W YBR235W VHC1 hom Verified 0.31558095253301 0.376160298536546 no 1764 0.385697055629772 1252 NA Vacuolar membrane cation-chloride cotransporter (CCC); likely mediates K+ and Cl- cotransport into the vacuole; has a role in potassium homeostasis and salt tolerance; similar to mammalian electroneutral Na(+)-(K+)-C1- cotransporter family transmembrane transport ion transmembrane transporter activity integral to membrane
YOR379C_d YOR379C YOR379C hom Dubious 0.315313829415071 0.376261692910291 no 1765 0.362048604366678 1222 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR378W Unknown Unknown Unknown
YDL114W_p YDL114W YDL114W hom Uncharacterized 0.312936192059175 0.377164570115956 no 1766 0.382124034503495 1277 NA FT OXIDATION-REDUCTION PROCESS Putative short-chain dehydrogenase/reductase; YDL114W is not an essential gene biological_process molecular_function integral to membrane
YKL066W_d YKL066W YKL066W hom Dubious 0.312605753390782 0.377290103243959 no 1767 0.337316783944182 1139 NA Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene YNK1 Unknown Unknown Unknown
YKR094C YKR094C RPL40B hom Verified 0.312414582632805 0.377362734635034 no 1768 0.366051617090354 1215 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RESPONSE TO DNA DAMAGE|TRANSLATION NUCLEUS|MITOCHONDRION RIBOSOME Ubiquitin-ribosomal 60S subunit protein L40B fusion protein; cleaved to yield ubiquitin and ribosomal protein L40B; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; homologous to mammalian ribosomal protein L40, no bacterial homolog; RPL40B has a paralog, RPL40A, that arose from the whole genome duplication cytoplasmic translation|protein ubiquitination|ribosome biogenesis structural constituent of ribosome|protein tag mitochondrion|cytosolic large ribosomal subunit
YER140W YER140W EMP65 hom Verified 0.312397928937298 0.377369062068995 no 1769 0.372748324731769 1238 NA FT MITOCHONDRION ER membrane protein of unknown function; forms an ER-membrane associated protein complex with Slp1p; identified along with SLP1 in a screen for mutants defective in the unfolded protein response (UPR); proposed to function in the folding of integral membrane proteins; interacts genetically with MPS1; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies protein folding in endoplasmic reticulum molecular_function mitochondrion|integral to membrane
YOR016C YOR016C ERP4 hom Verified 0.30945065784219 0.3784893703199 no 1770 0.374984228118857 1213 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport ER to Golgi vesicle-mediated transport molecular_function integral to membrane
YPR150W_d YPR150W YPR150W hom Dubious 0.309355660679145 0.378525497422112 no 1771 0.351633984696435 1181 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene SUE1/YPR151C Unknown Unknown Unknown
YPL077C_p YPL077C YPL077C hom Uncharacterized 0.309332342121011 0.378534365553797 no 1772 0.380975231997371 1257 NA Putative protein of unknown function; regulates PIS1 expression; mutant displays spore wall assembly defect in ether sensitivity screen; YPL077C is not an essential gene; YPL077C has a paralog, YBR197C, that arose from the whole genome duplication biological_process molecular_function cellular_component
YNL093W YNL093W YPT53 hom Verified 0.308332048923063 0.378914840830943 no 1773 0.442800977241788 1476 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING|VACUOLAR TRANSPORT PLASMA MEMBRANE Rab family GTPase; similar to Ypt51p and Ypt52p and to mammalian rab5; required for vacuolar protein sorting and endocytosis; YPT53 has a paralog, VPS21, that arose from the whole genome duplication endocytosis|protein targeting to vacuole GTPase activity late endosome
YMR158W-B_d YMR158W-B YMR158W-B hom Dubious 0.30753000797744 0.379219992932018 no 1774 0.361220465183074 1221 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene ATG16/YMR159C Unknown Unknown Unknown
YPL184C YPL184C MRN1 hom Verified 0.307394354680455 0.379271612318736 no 1775 0.379933720403187 1286 NA FT TRANSLATION RNA-binding protein that may be involved in translational regulation; binds specific categories of mRNAs, including those that contain upstream open reading frames (uORFs) and internal ribosome entry sites (IRES); interacts genetically with chromatin remodelers and splicing factors, linking chromatin state, splicing and as a result mRNA maturation biological_process molecular_function cytoplasm
YJR082C YJR082C EAF6 hom Verified 0.30672924954997 0.379524732169263 no 1776 0.371120377045374 1233 NA FT CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE NUCLEUS HISTONE ACETYLTRANSFERASE Subunit of the NuA4 acetyltransferase complex that acetylates histone H4 and NuA3 acetyltransferase complex that acetylates histone H3 DNA repair|histone acetylation histone acetyltransferase activity nucleus|NuA4 histone acetyltransferase complex|NuA3 histone acetyltransferase complex
YKL134C YKL134C OCT1 hom Verified 0.306630026989079 0.379562497846591 no 1777 0.372576039901004 1218 NA FT PROTEIN LOCALIZATION|ION HOMEOSTASIS|PROTEOLYSIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS MITOCHONDRION Mitochondrial intermediate peptidase, cleaves destabilizing N-terminal residues of a subset of proteins upon import, after their cleavage by mitochondrial processing peptidase (Mas1p-Mas2p); may contribute to mitochondrial iron homeostasis cellular iron ion homeostasis|protein processing involved in protein targeting to mitochondrion metalloendopeptidase activity mitochondrion
YBR276C YBR276C PPS1 hom Verified 0.306349571377875 0.379669249904412 no 1778 0.338614283380144 1148 NA FT CELL CYCLE|SIGNALING|PROTEIN PHOSPHORYLATION NUCLEUS Protein phosphatase with specificity for serine, threonine, and tyrosine residues; has a role in the DNA synthesis phase of the cell cycle inactivation of MAPK activity|protein dephosphorylation|regulation of S phase of mitotic cell cycle protein tyrosine/serine/threonine phosphatase activity cellular_component
YIL089W YIL089W YIL089W hom Verified 0.305537681891898 0.3799783375627 no 1779 0.364018905420998 1207 NA FT ENDOPLASMIC RETICULUM Protein of unknown function found in the ER and vacuole lumen; overexpression of YIL089W affects endocytic protein trafficking biological_process molecular_function fungal-type vacuole lumen|integral to membrane|endoplasmic reticulum
YOR142W YOR142W LSC1 hom Verified 0.305448186313044 0.380012413371933 no 1780 0.36288990371776 1197 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION Alpha subunit of succinyl-CoA ligase, which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate; phosphorylated tricarboxylic acid cycle|succinyl-CoA metabolic process succinate-CoA ligase (ADP-forming) activity mitochondrial nucleoid|mitochondrion
YDL184C YDL184C RPL41A hom Verified 0.304891557029554 0.380224373162359 no 1781 0.380556629910424 1235 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L41A; comprises only 25 amino acids; rpl41a rpl41b double null mutant is viable; homologous to mammalian ribosomal protein L41, no bacterial homolog; RPL41A has a paralog, RPL41B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YDR101C YDR101C ARX1 hom Verified 0.304869541585218 0.380232757199977 no 1782 0.390789792153453 1283 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|PROTEOLYSIS NUCLEUS RIBOSOME Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex ribosomal large subunit biogenesis molecular_function nucleoplasm|cytosolic large ribosomal subunit|cytoplasm
YOR150W YOR150W MRPL23 hom Verified 0.303847607574527 0.380621997369795 no 1783 0.416665981350909 1370 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YMR307W YMR307W GAS1 hom Verified 0.303808765049554 0.38063679432358 no 1784 0.393419772400294 1301 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|GENE SILENCING NUCLEUS|MITOCHONDRION|PLASMA MEMBRANE Beta-1,3-glucanosyltransferase, required for cell wall assembly and also has a role in transcriptional silencing; localizes to the cell surface via a glycosylphosphatidylinositol (GPI) anchor; also found at the nuclear periphery fungal-type cell wall organization|chromatin silencing|filamentous growth 1,3-beta-glucanosyltransferase activity mitochondrion|membrane raft|primary cell septum|nuclear periphery|integral to membrane|fungal-type cell wall|plasma membrane|cellular bud scar|ER to Golgi transport vesicle
YDR051C YDR051C DET1 hom Verified 0.303506072303754 0.380752110279074 no 1785 0.374720445963498 1228 NA FT NUCLEUS Acid phosphatase involved in the non-vesicular transport of sterols in both directions between the endoplasmic reticulum and plasma membrane; deletion confers sensitivity to nickel intracellular sterol transport|dephosphorylation acid phosphatase activity nucleus|cytoplasm
YPL245W_p YPL245W YPL245W hom Uncharacterized 0.303157617271781 0.380884873274189 no 1786 0.366901443205434 1215 NA FT NUCLEUS Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm biological_process molecular_function nucleus|cytoplasm
YLR236C_d YLR236C YLR236C hom Dubious 0.302784079298337 0.381027208562925 no 1787 0.375458539207661 1226 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YNL055C YNL055C POR1 hom Verified 0.302059581408143 0.381303321732084 no 1788 0.4001888682747 1332 NA FT ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS MITOCHONDRION Mitochondrial porin (voltage-dependent anion channel); outer membrane protein required for the maintenance of mitochondrial osmotic stability and mitochondrial membrane permeability; phosphorylated; protein abundance increases in response to DNA replication stress; POR1 has a paralog, POR2, that arose from the whole genome duplication DNA transport|mitochondrion organization|apoptotic process|ion transport|cell redox homeostasis voltage-gated anion channel activity mitochondrial outer membrane|mitochondrion|integral to mitochondrial outer membrane
YCL025C YCL025C AGP1 hom Verified 0.301220901682072 0.381623026165422 no 1789 0.344921520439144 1144 NA FT PLASMA MEMBRANE Low-affinity amino acid permease with broad substrate range; involved in uptake of asparagine, glutamine, and other amino acids; expression regulated by SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p); AGP1 has a paralog, GNP1, that arose from the whole genome duplication amino acid transport|transmembrane transport amino acid transmembrane transporter activity|L-proline transmembrane transporter activity integral to membrane|plasma membrane
YLR376C YLR376C PSY3 hom Verified 0.300877969641957 0.381753775024214 no 1790 0.371137729410403 1245 NA FT RESPONSE TO DNA DAMAGE NUCLEUS Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function; structural analysis reveals a similar DNA-binding region in both Psy3p and Csm2p and that both regions work together to form a single DNA binding site; deletion of PSY3 results in a mutator phenotype; deletion increases sensitivity to anticancer drugs oxaliplatin and cisplatin but not mitomycin C recombinational repair|error-free translesion synthesis molecular_function nucleus|Shu complex|cytoplasm
YDR484W YDR484W VPS52 hom Verified 0.300599621581452 0.381859910027435 no 1791 0.418357188029962 1363 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT GOLGI APPARATUS|CYTOSKELETON Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; involved in localization of actin and chitin actin filament-based process|Golgi to vacuole transport|retrograde transport, endosome to Golgi protein binding Golgi apparatus|GARP complex
YDR265W YDR265W PEX10 hom Verified 0.30022991909905 0.382000892493015 no 1792 0.380757324945408 1252 NA FT PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION Peroxisomal membrane E3 ubiquitin ligase, required for for Ubc4p-dependent Pex5p ubiquitination and peroxisomal matrix protein import; contains zinc-binding RING domain; mutations in human homolog cause various peroxisomal disorders protein import into peroxisome matrix|protein ubiquitination ubiquitin-protein ligase activity|protein binding peroxisomal membrane
YOR251C YOR251C TUM1 hom Verified 0.299533569575265 0.382266481131989 no 1793 0.35507722963006 1185 NA FT RNA PROCESSING MITOCHONDRION Rhodanese domain sulfur transferase, accepts persulfite from Nfs1p and transfers it to Uba4p in the pathway for 2-thiolation of the wobble uridine base of tRNAs; also stimulates sulfur transfer by Nfs1p; may be mitochondrially localized tRNA wobble position uridine thiolation|tRNA wobble uridine modification thiosulfate sulfurtransferase activity cytoplasm
YKL215C YKL215C OXP1 hom Verified 0.299381113787917 0.382324635369661 no 1794 0.343675927172452 1122 NA FT KETONE METABOLISM|AMINO ACID METABOLISM 5-oxoprolinase; enzyme is ATP-dependent and functions as a dimer; similar to mouse Oplah gene; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress glutathione metabolic process 5-oxoprolinase (ATP-hydrolyzing) activity cytoplasm
YDR475C YDR475C JIP4 hom Verified 0.298893349942601 0.382510710641883 no 1795 0.375767395113408 1240 NA Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence biological_process molecular_function cellular_component
YAL031C YAL031C GIP4 hom Verified 0.297385284954304 0.383086188352808 no 1796 0.37555471873428 1233 NA FT CHROMOSOME SEGREGATION Cytoplasmic Glc7-interacting protein whose overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation; potential Cdc28p substrate chromosome segregation|regulation of phosphoprotein phosphatase activity protein phosphatase 1 binding|protein phosphatase type 1 regulator activity cytoplasm
YDL107W YDL107W MSS2 hom Verified 0.295086386995211 0.38396394428157 no 1797 0.39341872855684 1301 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Peripherally bound inner membrane protein of the mitochondrial matrix involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18p protein insertion into mitochondrial membrane from inner side molecular_function extrinsic to mitochondrial inner membrane|mitochondrial matrix
YMR078C YMR078C CTF18 hom Verified 0.294565050486236 0.384163081888535 no 1798 0.357982546079609 1198 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION NUCLEUS|MITOCHONDRION|CHROMOSOME Subunit of a complex with Ctf8p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion; may have overlapping functions with Rad24p in the DNA damage replication checkpoint maintenance of DNA trinucleotide repeats|double-strand break repair via homologous recombination|DNA replication initiation|mitotic sister chromatid cohesion molecular_function mitochondrion|nuclear replication fork|Ctf18 RFC-like complex
YOR009W YOR009W TIR4 hom Verified 0.294466359726329 0.384200782753601 no 1799 0.375849842967457 1230 NA FT CELL WALL ORG/BIOGENESIS Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expressed under anaerobic conditions and required for anaerobic growth; transcription is also induced by cold shock biological_process molecular_function fungal-type cell wall
YGL054C YGL054C ERV14 hom Verified 0.293582725463377 0.384538388731153 no 1800 0.471347012791927 1558 NA FF|FT VESICLE-MEDIATED TRANSPORT|CELL CYCLE|SIGNALING|CELL DIVISION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS COPII-coated vesicle protein; involved in vesicle formation and incorporation of specific secretory cargo; required for the delivery of bud-site selection protein Axl2p to cell surface; related to Drosophila cornichon; ERV14 has a paralog, ERV15, that arose from the whole genome duplication ascospore formation|ER to Golgi vesicle-mediated transport|axial cellular bud site selection molecular_function integral to membrane|ER to Golgi transport vesicle|endoplasmic reticulum membrane
YIR029W YIR029W DAL2 hom Verified 0.292421504641729 0.38498218404836 no 1801 0.374534435367314 1222 NA Allantoicase, converts allantoate to urea and ureidoglycolate in the second step of allantoin degradation; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation allantoin catabolic process allantoicase activity cellular_component
YJL115W YJL115W ASF1 hom Verified 0.29188396143656 0.38518767335249 no 1802 0.346715000310087 1172 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS Nucleosome assembly factor, involved in chromatin assembly and disassembly, anti-silencing protein that causes derepression of silent loci when overexpressed; plays a role in regulating Ty1 transposition DNA replication-independent nucleosome assembly|histone acetylation|nucleosome disassembly|histone exchange|positive regulation of histone acetylation|chromatin silencing at silent mating-type cassette|chromatin silencing at telomere|DNA replication-dependent nucleosome assembly|regulation of transcription from RNA polymerase II promoter in response to stress histone binding chromatin assembly complex
YDR426C_d YDR426C YDR426C hom Dubious 0.29163585023783 0.385282530928879 no 1803 0.369938558306059 1201 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SNX41 Unknown Unknown Unknown
YGR153W_p YGR153W YGR153W hom Uncharacterized 0.290525473477347 0.385707132863032 no 1804 0.37960357247699 1258 NA Putative protein of unknown function biological_process molecular_function cellular_component
YPR038W_d YPR038W IRC16 hom Dubious 0.288557417578503 0.386460042845677 no 1805 0.378370046235431 1255 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene YPR037C; null mutant displays increased levels of spontaneous Rad52p foci Unknown Unknown Unknown
YOL113W YOL113W SKM1 hom Verified 0.287693559980322 0.386790660051393 no 1806 0.400003633375739 1327 NA FT CELL DIVISION|PROTEIN PHOSPHORYLATION NUCLEUS|PLASMA MEMBRANE Member of the PAK family of serine/threonine protein kinases with similarity to Ste20p and Cla4p; involved in down-regulation of sterol uptake; proposed to be a downstream effector of Cdc42p during polarized growth negative regulation of gene expression|cytokinetic cell separation|protein phosphorylation|sterol import protein serine/threonine kinase activity|protein kinase activity plasma membrane|nucleus
YIR020C_p YIR020C YIR020C hom Uncharacterized 0.28628404360652 0.387330289140693 no 1807 0.36392326895293 1214 NA Protein of unknown function; mRNA identified as translated by ribosome profiling data biological_process molecular_function cellular_component
YDR521W_d YDR521W YDR521W hom Dubious 0.286180190754567 0.387370057518384 no 1808 0.370720269851148 1232 NA Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol Unknown Unknown Unknown
YLR182W YLR182W SWI6 hom Verified 0.285503892950924 0.387629061162052 no 1809 0.421745891678764 1364 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE NUCLEUS Transcription cofactor; forms complexes with Swi4p and Mbp1p to regulate transcription at the G1/S transition; involved in meiotic gene expression; also binds Stb1p to regulate transcription at START; cell wall stress induces phosphorylation by Mpk1p, which regulates Swi6p localization; required for the unfolded protein response, independently of its known transcriptional coactivators positive regulation of transcription from RNA polymerase II promoter in response to heat stress|positive regulation of transcription involved in G1/S phase of mitotic cell cycle|positive regulation of reciprocal meiotic recombination|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II transcription coactivator activity SBF transcription complex|MBF transcription complex|nucleus|cytoplasm
YOR312C YOR312C RPL20B hom Verified 0.284797179890217 0.387899766458521 no 1810 0.341908284285382 1150 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L20B; homologous to mammalian ribosomal protein L18A, no bacterial homolog; RPL20B has a paralog, RPL20A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YKL117W YKL117W SBA1 hom Verified 0.284090830870077 0.388170386758069 no 1811 0.376727493519938 1208 NA FT NUCLEUS Co-chaperone that binds to and regulates Hsp90 family chaperones; important for pp60v-src activity in yeast; homologous to the mammalian p23 proteins, and like p23 can regulate telomerase activity; protein abundance increases in response to DNA replication stress protein folding|positive regulation of telomere maintenance via telomerase|regulation of telomerase activity chaperone binding nucleus|cytoplasm
YIL038C YIL038C NOT3 hom Verified 0.283065496155165 0.388563315205821 no 1812 0.371843778669181 1231 NA FT TRANSCRIPTION FROM RNA POL II|RNA PROCESSING NUCLEUS Subunit of the CCR4-NOT complex, which is a global transcriptional regulator with roles in transcription initiation and elongation and in mRNA degradation regulation of transcription from RNA polymerase II promoter|nuclear-transcribed mRNA poly(A) tail shortening|positive regulation of transcription elongation from RNA polymerase II promoter|protein ubiquitination ubiquitin-protein ligase activity CCR4-NOT core complex|cytoplasm
YOL159C YOL159C YOL159C hom Verified 0.283063980996949 0.388563895928769 no 1813 0.376193331086271 1260 NA Soluble protein of unknown function; deletion mutants are viable and have elevated levels of Ty1 retrotransposition and Ty1 cDNA biological_process molecular_function cellular_component
YJR090C YJR090C GRR1 hom Verified 0.282931440541709 0.388614696395154 no 1814 0.420708231566001 1375 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CARBOHYDRATE METABOLISM|PROTEOLYSIS NUCLEUS|SITE OF POLARIZED GROWTH|CYTOSKELETON UBIQUITIN LIGASE COMPLEX F-box protein component of the SCF ubiquitin-ligase complex; involved in carbon catabolite repression, glucose-dependent divalent cation transport, high-affinity glucose transport, morphogenesis, and sulfite detoxification SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|cellular response to methylmercury|cell cycle arrest in response to pheromone|G1/S transition of mitotic cell cycle|response to DNA damage stimulus|protein ubiquitination ubiquitin-protein ligase activity|protein binding, bridging cellular bud neck contractile ring|SCF ubiquitin ligase complex|nucleus|cytoplasm
YOL028C YOL028C YAP7 hom Verified 0.282738773331556 0.388688545804977 no 1815 0.393714318275595 1301 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Putative basic leucine zipper (bZIP) transcription factor; YAP7 has a paralog, YAP5, that arose from the whole genome duplication positive regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding nucleus
YLR428C_d YLR428C YLR428C hom Dubious 0.282550980079781 0.388760530896498 no 1816 0.397811576878685 1327 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CRN1 Unknown Unknown Unknown
YKL115C_d YKL115C YKL115C hom Dubious 0.282500217611782 0.388779989870896 no 1817 0.379731607925685 1257 NA Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene PRR1 Unknown Unknown Unknown
YLL005C YLL005C SPO75 hom Verified 0.281511212639048 0.389159164619623 no 1818 0.364560900141737 1184 NA FT CELL WALL ORG/BIOGENESIS Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis ascospore wall assembly|ascospore formation molecular_function integral to membrane
YDR295C YDR295C HDA2 hom Verified 0.280147432970276 0.389682197396678 no 1819 0.371752626544128 1233 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS|CHROMOSOME Subunit of a possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex containing an Hda1p homodimer and an Hda2p-Hda3p heterodimer; involved in telomere maintenance negative regulation of transcription from RNA polymerase II promoter|gene silencing by RNA|histone deacetylation|gene silencing involved in chronological cell aging histone deacetylase activity|chromatin binding|DNA binding nucleus|HDA1 complex
YIL110W YIL110W HPM1 hom Verified 0.279575151877176 0.389901736546321 no 1820 0.377398949057316 1239 NA FT NUCLEUS AdoMet-dependent methyltransferase involved in a novel 3-methylhistidine modification of ribosomal protein Rpl3p; seven beta-strand MTase family member; null mutant exhibits a weak vacuolar protein sorting defect and caspofungin resistance peptidyl-histidine methylation, to form tele-methylhistidine S-adenosylmethionine-dependent methyltransferase activity|protein-histidine N-methyltransferase activity nucleus|cytoplasm
YPL189C-A YPL189C-A COA2 hom Verified 0.279551993659718 0.38991062126905 no 1821 0.390534414825007 1282 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Cytochrome oxidase assembly factor; null mutation results in respiratory deficiency with specific loss of cytochrome oxidase activity; functions downstream of assembly factors Mss51p and Coa1p and interacts with assembly factor Shy1p mitochondrial respiratory chain complex IV assembly molecular_function mitochondrial matrix
YER044C YER044C ERG28 hom Verified 0.278949115052342 0.390141937763533 no 1822 0.397049810399128 1315 NA FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Endoplasmic reticulum membrane protein, may facilitate protein-protein interactions between the Erg26p dehydrogenase and the Erg27p 3-ketoreductase and/or tether these enzymes to the ER, also interacts with Erg6p ergosterol biosynthetic process protein binding, bridging endoplasmic reticulum membrane
YOR135C_d YOR135C IRC14 hom Dubious 0.278318448573388 0.390383957728503 no 1823 0.370612809629366 1225 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YOR136W; null mutant displays increased levels of spontaneous Rad52 foci Unknown Unknown Unknown
YGL235W_p YGL235W YGL235W hom Uncharacterized 0.277152178538525 0.390831628865291 no 1824 0.376044042869602 1227 NA Putative protein of unknown function; potential Cdc28p substrate; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2 biological_process molecular_function cellular_component
YFL018C YFL018C LPD1 hom Verified 0.275248911808871 0.391562505714769 no 1825 0.366484797994568 1232 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS MITOCHONDRION Dihydrolipoamide dehydrogenase, the lipoamide dehydrogenase component (E3) of the pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase multi-enzyme complexes L-serine biosynthetic process|2-oxoglutarate metabolic process|leucine catabolic process|glycine catabolic process|isoleucine catabolic process|pyruvate metabolic process|valine catabolic process|hydrogen peroxide metabolic process glycine dehydrogenase (decarboxylating) activity|pyruvate dehydrogenase activity|oxoglutarate dehydrogenase (succinyl-transferring) activity|dihydrolipoyl dehydrogenase activity mitochondrial nucleoid|mitochondrion|glycine cleavage complex|mitochondrial oxoglutarate dehydrogenase complex
YCR020C YCR020C PET18 hom Verified 0.274085129422213 0.392009600708638 no 1826 0.407786315803128 1342 NA Protein of unknown function, has weak similarity to proteins involved in thiamin metabolism; expression is induced in the absence of thiamin thiamine metabolic process molecular_function cytosol
YBR010W YBR010W HHT1 hom Verified 0.273298151424752 0.392312018106858 no 1827 0.403593021444685 1340 NA FT CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME Histone H3, core histone protein required for chromatin assembly, part of heterochromatin-mediated telomeric and HM silencing; one of two identical histone H3 proteins (see HHT2); regulated by acetylation, methylation, and phosphorylation chromatin assembly or disassembly|global genome nucleotide-excision repair|rRNA transcription|sexual sporulation resulting in formation of a cellular spore|mitotic cell cycle spindle assembly checkpoint DNA binding replication fork protection complex|nucleus|nuclear nucleosome
YER015W YER015W FAA2 hom Verified 0.272858584579104 0.392480961779625 no 1828 0.397365971778132 1328 NA FT KETONE METABOLISM|LIPID METABOLISM MITOCHONDRION Medium chain fatty acyl-CoA synthetase, activates imported fatty acids; accepts a wide range of fatty acid chain lengths with a preference for medium chains, C9:0-C13:0; localized to the peroxisome long-chain fatty acid metabolic process long-chain fatty acid-CoA ligase activity|very long-chain fatty acid-CoA ligase activity|medium-chain fatty acid-CoA ligase activity mitochondrion|peroxisome
YJR099W YJR099W YUH1 hom Verified 0.272604292312074 0.392578706042826 no 1829 0.386633139217564 1292 NA FT PROTEOLYSIS Ubiquitin C-terminal hydrolase that cleaves ubiquitin-protein fusions to generate monomeric ubiquitin; hydrolyzes the peptide bond at the C-terminus of ubiquitin; also the major processing enzyme for the ubiquitin-like protein Rub1p protein deubiquitination ubiquitin-specific protease activity cytoplasm
YDL002C YDL002C NHP10 hom Verified 0.272404250641943 0.39265560235135 no 1830 0.398642648238583 1344 NA FT CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME Protein related to mammalian high mobility group proteins; preferentially binds DNA ends, protecting them from exonucleatic cleavage; likely component of the chromatin-remodeling complex INO80 complex; proposed to be involved in DNA repair double-strand break repair|nucleosome mobilization DNA end binding|loop DNA binding nucleus|Ino80 complex
YPL121C YPL121C MEI5 hom Verified 0.272161617375577 0.392748876554672 no 1831 0.378115614129473 1256 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME Meiosis specific protein involved in DMC1-dependent meiotic recombination, forms heterodimer with Sae3p; proposed to be an assembly factor for Dmc1p meiotic DNA recombinase assembly|reciprocal meiotic recombination molecular_function condensed nuclear chromosome
YML028W YML028W TSA1 hom Verified 0.272098757965329 0.39277304226492 no 1832 0.390811812003575 1267 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|TRANSLATION|OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS Thioredoxin peroxidase; acts as both a ribosome-associated and free cytoplasmic antioxidant; self-associates to form a high-molecular weight chaperone complex under oxidative stress; deletion results in mutator phenotype; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress protein folding|cellular response to oxidative stress|replicative cell aging|DNA protection|DNA damage checkpoint|cell redox homeostasis|response to hydroperoxide unfolded protein binding|ribosome binding|peroxiredoxin activity|thioredoxin peroxidase activity cytosol|polysome|cytoplasm
YML058W YML058W SML1 hom Verified 0.271175597251074 0.393127990299303 no 1833 0.349147941392049 1171 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|MITOCHONDRION ORGANIZATION NUCLEUS Ribonucleotide reductase inhibitor involved in regulating dNTP production; regulated by Mec1p and Rad53p during DNA damage and S phase mitochondrion organization|response to DNA damage stimulus enzyme inhibitor activity nucleus|cytoplasm
YGL121C YGL121C GPG1 hom Verified 0.27030358476088 0.393463353867585 no 1834 0.375637539053619 1258 NA FT SIGNALING Proposed gamma subunit of the heterotrimeric G protein that interacts with the receptor Gpr1p; involved in regulation of pseudohyphal growth; requires Gpb1p or Gpb2p to interact with Gpa2p; overproduction causes prion curing signal transduction|invasive growth in response to glucose limitation signal transducer activity cellular_component
YLR021W YLR021W IRC25 hom Verified 0.269990007349462 0.393583970606695 no 1835 0.396429698250725 1282 NA FT PROTEIN COMPLEX ORG/BIOGENESIS Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions proteasome assembly|chaperone-mediated protein complex assembly|nuclear-transcribed mRNA catabolic process, non-stop decay molecular_function intracellular
YKL046C YKL046C DCW1 hom Verified 0.268390367676209 0.394199426552259 no 1836 0.362366019359375 1205 NA FT CELL WALL ORG/BIOGENESIS|CELL DIVISION|CARBOHYDRATE METABOLISM PLASMA MEMBRANE Putative mannosidase, GPI-anchored membrane protein required for cell wall biosynthesis in bud formation;homologous to Dfg5p fungal-type cell wall biogenesis|budding cell bud growth mannosidase activity anchored to plasma membrane
YDL155W YDL155W CLB3 hom Verified 0.26827295602609 0.394244610715866 no 1837 0.39671633379991 1306 NA FT CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION NUCLEUS B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation; relative distribution to the nucleus increases upon DNA replication stress G2/M transition of mitotic cell cycle|S phase of mitotic cell cycle|regulation of cyclin-dependent protein kinase activity|positive regulation of spindle pole body separation cyclin-dependent protein kinase regulator activity nucleus|cytoplasm
YML083C YML083C YML083C hom Verified 0.267415155878987 0.394574765756011 no 1838 0.386984073804458 1301 NA Protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; strong increase in transcript abundance during anaerobic growth compared to aerobic growth; cells deleted for YML083C do not exhibit growth defects in anerobic or anaerobic conditions biological_process molecular_function cellular_component
YBL060W YBL060W YEL1 hom Verified 0.266929740961361 0.394761628605868 no 1839 0.405203585236438 1327 NA FT PROTEIN LOCALIZATION|LIPID METABOLISM|SIGNALING SITE OF POLARIZED GROWTH|PLASMA MEMBRANE Guanine nucleotide exchange factor specific for Arf3p; localized to the bud neck and tip; required for localization of Arf3p to the bud neck and tip positive regulation of phosphatidylinositol biosynthetic process|protein localization|actin cortical patch localization ARF guanyl-nucleotide exchange factor activity cellular bud neck|cellular bud tip|cytoplasm
YNL086W_p YNL086W SNN1 hom Uncharacterized 0.266528430377367 0.394916133366527 no 1840 0.385429813467774 1274 NA Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to endosomes biological_process molecular_function endosome|BLOC-1 complex
YDR538W YDR538W PAD1 hom Verified 0.266513565220177 0.394921856776498 no 1841 0.384680715540969 1277 NA FT KETONE METABOLISM MITOCHONDRION Phenylacrylic acid decarboxylase, confers resistance to cinnamic acid, decarboxylates aromatic carboxylic acids to the corresponding vinyl derivatives; also has mRNA binding activity; homolog of E. coli UbiX cinnamic acid catabolic process|aromatic compound catabolic process mRNA binding|carboxy-lyase activity mitochondrion
YPL116W YPL116W HOS3 hom Verified 0.265915324130058 0.395152211459496 no 1842 0.385623148728161 1272 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION NUCLEUS|SITE OF POLARIZED GROWTH Trichostatin A-insensitive homodimeric histone deacetylase (HDAC) with specificity in vitro for histones H3, H4, H2A, and H2B; similar to Hda1p, Rpd3p, Hos1p, and Hos2p; deletion results in increased histone acetylation at rDNA repeats regulation of transcription involved in G1/S phase of mitotic cell cycle|positive regulation of transcription from RNA polymerase II promoter|histone deacetylation histone deacetylase activity nucleus|cellular bud neck|cytoplasm
YCR075W-A_p YCR075W-A YCR075W-A hom Uncharacterized 0.264335698347869 0.395760627456154 no 1843 0.401574683744204 1297 NA Putative protein of unknown function; identified by homology to Ashbya gossypii; YCR075W-A has a paralog, YNR034W-A, that arose from the whole genome duplication biological_process molecular_function cellular_component
YGR007W YGR007W ECT1 hom Verified 0.263575964282888 0.396053340735618 no 1844 0.39860899427997 1319 NA FT LIPID METABOLISM NUCLEUS Ethanolamine-phosphate cytidylyltransferase, catalyzes the second step of phosphatidylethanolamine biosynthesis; involved in the maintenance of plasma membrane; similar to mammalian CTP: phosphocholine cytidylyl-transferases phosphatidylethanolamine biosynthetic process ethanolamine-phosphate cytidylyltransferase activity nucleus|cytoplasm
YMR254C_d YMR254C YMR254C hom Dubious 0.263412034295157 0.396116508009867 no 1845 0.396390737741374 1298 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YLR193C YLR193C UPS1 hom Verified 0.263030894189782 0.396263383574575 no 1846 0.364802489233632 1227 NA FT LIPID METABOLISM MITOCHONDRION Phosphatidic acid transfer protein; plays a role in phospholipid metabolism by transporting phosphatidic acid from the outer to the inner mitochondrial membrane; localizes to the mitochondrial intermembrane space; null mutant has altered cardiolipin and phosphatidic acid levels; ortholog of human PRELI Unknown|cardiolipin metabolic process molecular_function mitochondrion|extrinsic to mitochondrial inner membrane|mitochondrial intermembrane space
YBR030W YBR030W RKM3 hom Verified 0.261823030803446 0.396728941132307 no 1847 0.368734051808041 1235 NA FT NUCLEUS Ribosomal lysine methyltransferase specific for monomethylation of Rpl42ap and Rpl42bp (lysine 40); nuclear SET domain containing protein peptidyl-lysine monomethylation protein-lysine N-methyltransferase activity nucleus
YCR088W YCR088W ABP1 hom Verified 0.261384998395576 0.396897812287245 no 1848 0.391662607501391 1280 NA FT PROTEIN LOCALIZATION|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH|CYTOSKELETON Actin-binding protein of the cortical actin cytoskeleton, important for activation of the Arp2/3 complex that plays a key role actin in cytoskeleton organization; phosphorylation within its PRR (Proline-Rich Region), mediated by Cdc28p and Pho85p, protects Abp1p from proteolysis mediated by its own PEST sequences protein localization|actin cortical patch assembly actin filament binding cell cortex|mating projection tip|cytoplasm|actin cortical patch
YBR250W YBR250W SPO23 hom Verified 0.261252118346751 0.396949044300953 no 1849 0.400289898552484 1318 NA FT CELL CYCLE Protein of unknown function; associates with meiosis-specific protein Spo1p meiosis molecular_function cellular_component
YKL110C YKL110C KTI12 hom Verified 0.26099909500194 0.397046602579637 no 1850 0.41312147929625 1370 NA FT TRANSCRIPTION FROM RNA POL II|RNA PROCESSING NUCLEUS Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p regulation of transcription from RNA polymerase II promoter|cell growth|tRNA wobble uridine modification chromatin binding nucleus|cytoplasm
YMR155W_p YMR155W YMR155W hom Uncharacterized 0.259297459057384 0.397702869881912 no 1851 0.39029047588828 1297 NA Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen biological_process molecular_function integral to membrane
YCR007C_p YCR007C YCR007C hom Uncharacterized 0.259154473906465 0.397758027959474 no 1852 0.404157864561424 1339 NA Putative integral membrane protein, member of DUP240 gene family; YCR007C is not an essential gene biological_process molecular_function cellular_component
YBR176W YBR176W ECM31 hom Verified 0.2589330613322 0.3978434443015 no 1853 0.408782560022818 1362 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM MITOCHONDRION Ketopantoate hydroxymethyltransferase, required for pantothenic acid biosynthesis, converts 2-oxoisovalerate into 2-dehydropantoate pantothenate biosynthetic process 3-methyl-2-oxobutanoate hydroxymethyltransferase activity mitochondrion
YDL081C YDL081C RPP1A hom Verified 0.258541825108603 0.39799438702625 no 1854 0.394592007457323 1304 NA FT TRANSLATION RIBOSOME Ribosomal stalk protein P1 alpha, involved in the interaction between translational elongation factors and the ribosome; accumulation of P1 in the cytoplasm is regulated by phosphorylation and interaction with the P2 stalk component cytoplasmic translation|translational elongation structural constituent of ribosome cytosolic large ribosomal subunit
YOR264W YOR264W DSE3 hom Verified 0.257854180637267 0.398259723913608 no 1855 0.386061466128057 1287 NA FT CELL CYCLE SITE OF POLARIZED GROWTH Daughter cell-specific protein, may help establish daughter fate; relocalizes from bud neck to cytoplasm upon DNA replication stress biological_process molecular_function cellular bud neck
YLR460C_p YLR460C YLR460C hom Uncharacterized 0.257778750944909 0.39828883234285 no 1856 0.370664445666799 1224 NA FT OXIDATION-REDUCTION PROCESS Member of the quinone oxidoreductase family, up-regulated in response to the fungicide mancozeb; possibly up-regulated by iodine biological_process molecular_function cellular_component
YIL044C YIL044C AGE2 hom Verified 0.257589129291127 0.398362010117503 no 1857 0.400149644141434 1312 NA FT VESICLE-MEDIATED TRANSPORT|SIGNALING|NUCLEOTIDE METABOLISM GOLGI APPARATUS ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector, involved in Trans-Golgi-Network (TGN) transport; contains C2C2H2 cysteine/histidine motif ER to Golgi vesicle-mediated transport|intra-Golgi vesicle-mediated transport ARF GTPase activator activity clathrin-coated vesicle
YML054C-A_p YML054C-A YML054C-A hom Uncharacterized 0.256893225328279 0.398630600265062 no 1858 0.380200846334447 1230 NA Putative protein of unknown function biological_process molecular_function cellular_component
YOL129W YOL129W VPS68 hom Verified 0.256266991883921 0.398872341527656 no 1859 0.404110964175795 1338 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT MITOCHONDRION Vacuolar membrane protein of unknown function involved in vacuolar protein sorting; also detected in the mitochondria late endosome to vacuole transport via multivesicular body sorting pathway|protein targeting to vacuole molecular_function Vps55/Vps68 complex|mitochondrion|fungal-type vacuole membrane|integral to membrane
YER096W YER096W SHC1 hom Verified 0.255477839911949 0.399177028525058 no 1860 0.407579406807872 1318 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM Sporulation-specific activator of Chs3p (chitin synthase III); required for the synthesis of the chitosan layer of ascospores; transcriptionally induced at alkaline pH; SHC1 has a paralog, SKT5, that arose from the whole genome duplication ascospore formation|chitin biosynthetic process enzyme activator activity prospore membrane
YEL029C YEL029C BUD16 hom Verified 0.254742847601449 0.399460860049761 no 1861 0.413747387356088 1363 NA FT CELL CYCLE|CELL DIVISION|COFACTOR METABOLISM NUCLEUS Putative pyridoxal kinase, a key enzyme involved in pyridoxal 5'-phosphate synthesis, the active form of vitamin B6; required for genome integrity; involved in bud-site selection; similarity to yeast BUD17 and human pyridoxal kinase (PDXK) pyridoxal phosphate biosynthetic process|cellular bud site selection pyridoxal kinase activity cytoplasm
YOR211C YOR211C MGM1 hom Verified 0.254740923973879 0.39946160296562 no 1862 0.395801533355816 1310 NA FT MEMBRANE ORGANIZATION|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial GTPase, present in complex with Ugo1p and Fzo1p; required for mt morphology and genome maintenance; exists as long and short form with different distributions; homolog of human OPA1 involved in autosomal dominant optic atrophy mitochondrion organization|mitochondrial genome maintenance|mitochondrial fusion GTPase activity intrinsic to mitochondrial inner membrane|extrinsic to mitochondrial inner membrane|mitochondrion|mitochondrial inner boundary membrane|mitochondrial crista|mitochondrial intermembrane space
YLR373C YLR373C VID22 hom Verified 0.25458943524066 0.399520109915178 no 1863 0.407747984078603 1355 NA FT PROTEIN LOCALIZATION NUCLEUS|PLASMA MEMBRANE Glycosylated integral membrane protein localized to the plasma membrane; plays a role in fructose-1,6-bisphosphatase (FBPase) degradation; involved in FBPase transport from the cytosol to Vid (vacuole import and degradation) vesicles vacuolar protein catabolic process molecular_function integral to plasma membrane
YIL099W YIL099W SGA1 hom Verified 0.254358943485571 0.399609133203346 no 1864 0.399947561185079 1328 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY Intracellular sporulation-specific glucoamylase involved in glycogen degradation; induced during starvation of a/a diploids late in sporulation, but dispensable for sporulation ascospore formation|glycogen catabolic process glucan 1,4-alpha-glucosidase activity fungal-type vacuole
YPL205C_d YPL205C YPL205C hom Dubious 0.252906788526812 0.400170121744646 no 1865 0.367487874114284 1264 NA Hypothetical protein; deletion of locus affects telomere length Unknown Unknown Unknown
YJR104C YJR104C SOD1 hom Verified 0.252726525242928 0.400239774468345 no 1866 0.457221062786453 1525 NA FF|FT ION HOMEOSTASIS|CELL WALL ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|RESPONSE TO OXIDATIVE STRESS NUCLEUS|MITOCHONDRION Cytosolic copper-zinc superoxide dismutase; some mutations are analogous to those that cause ALS (amyotrophic lateral sclerosis) in humans; protein abundance increases in response to DNA replication stress and in response to prolonged exposure to boric acid cellular copper ion homeostasis|fungal-type cell wall organization|superoxide metabolic process|cellular zinc ion homeostasis|positive regulation of sequence-specific DNA binding transcription factor activity|age-dependent response to reactive oxygen species involved in chronological cell aging superoxide dismutase activity cytosol|mitochondrion|nucleus|mitochondrial intermembrane space
YMR225C YMR225C MRPL44 hom Verified 0.252312851364335 0.400399627732301 no 1867 0.405114655258948 1337 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YKL097C_d YKL097C YKL097C hom Dubious 0.251223983171463 0.400820471570048 no 1868 0.394919276302816 1336 NA Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species Unknown Unknown Unknown
YFR026C YFR026C ULI1 hom Verified 0.249382340258364 0.401532522071369 no 1869 0.404129308017774 1344 NA FT SIGNALING Putative protein of unknown function involved in and induced by the endoplasmic reticulum unfolded protein response endoplasmic reticulum unfolded protein response molecular_function cellular_component
YER175W-A_p YER175W-A YER175W-A hom Uncharacterized 0.249084680927256 0.401647639467122 no 1870 0.397168256524581 1309 NA Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching biological_process molecular_function cellular_component
YML054C YML054C CYB2 hom Verified 0.2490489118241 0.401661473459962 no 1871 0.353859075410761 1182 NA FT KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Cytochrome b2 (L-lactate cytochrome-c oxidoreductase), component of the mitochondrial intermembrane space, required for lactate utilization; expression is repressed by glucose and anaerobic conditions lactate metabolic process L-lactate dehydrogenase (cytochrome) activity mitochondrion|mitochondrial intermembrane space
YHR095W_d YHR095W YHR095W hom Dubious 0.246559559388361 0.402624552653332 no 1872 0.403981862864116 1326 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YLR282C_d YLR282C YLR282C hom Dubious 0.246399574272056 0.402686467881707 no 1873 0.393939572330292 1285 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion mutation confers an increase in Ty1 transposition Unknown Unknown Unknown
YCR092C YCR092C MSH3 hom Verified 0.244436113535438 0.403446537653436 no 1874 0.400980137041265 1337 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME Mismatch repair protein, forms dimers with Msh2p that mediate repair of insertion or deletion mutations and removal of nonhomologous DNA ends, contains a PCNA (Pol30p) binding motif required for genome stability mismatch repair|mitotic recombination|meiotic mismatch repair|removal of nonhomologous ends|DNA recombination DNA insertion or deletion binding|mismatched DNA binding|double-strand/single-strand DNA junction binding|loop DNA binding|Y-form DNA binding MutSbeta complex|nucleus|cytoplasm
YDL010W YDL010W GRX6 hom Verified 0.244359882363454 0.403476054664284 no 1875 0.401077996567527 1297 NA FT RESPONSE TO OXIDATIVE STRESS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS Cis-golgi localized monothiol glutaredoxin, binds Fe-S cluster; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; GRX6 has a paralog, GRX7, that arose from the whole genome duplication cellular response to oxidative stress glutathione-disulfide reductase activity|iron ion binding|protein homodimerization activity|2 iron, 2 sulfur cluster binding integral to membrane|Golgi apparatus|Golgi lumen|endoplasmic reticulum membrane|fungal-type vacuole|cis-Golgi network
YML030W YML030W RCF1 hom Verified 0.244275053583244 0.403508901349344 no 1876 0.405560847132498 1347 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Cytochrome c oxidase subunit; required for assembly of the Complex III-Complex IV supercomplex, and for assembly of Cox13p and Rcf2p into cytochrome c oxidase; similar to Rcf2p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; required for growth under hypoxic conditions; member of the hypoxia induced gene family; C. elegans and human orthologs are functional in yeast mitochondrial respiratory chain complex IV assembly|mitochondrial respiratory chain supercomplex assembly molecular_function mitochondrion|mitochondrial respiratory chain supercomplex|integral to mitochondrial inner membrane|mitochondrial respiratory chain complex IV
YDR430C YDR430C CYM1 hom Verified 0.244139739236126 0.403561298038679 no 1877 0.391715968450188 1277 NA FT PROTEOLYSIS MITOCHONDRION Lysine-specific metalloprotease of the mitochondrial intermembrane space, member of the pitrilysin family; degrades proteins and presequence peptides cleaved from imported proteins; required for normal mitochondrial morphology proteolysis|proteolysis involved in cellular protein catabolic process metalloendopeptidase activity mitochondrion|mitochondrial intermembrane space
YJL056C YJL056C ZAP1 hom Verified 0.244092122864217 0.403579736556245 no 1878 0.489254164243104 1633 NA FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS NUCLEUS Zinc-regulated transcription factor; binds to zinc-responsive promoters to induce transcription of certain genes in presence of zinc, represses other genes in low zinc; regulates its own transcription; contains seven zinc-finger domains regulation of transcription from RNA polymerase II promoter in response to zinc ion starvation|positive regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding RNA polymerase II transcription factor activity|RNA polymerase II regulatory region sequence-specific DNA binding|zinc ion binding nucleus
YOR180C YOR180C DCI1 hom Verified 0.243979244111718 0.403623447522506 no 1879 0.432418322648868 1429 NA FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS Peroxisomal protein; identification as a delta(3,5)-delta(2,4)-dienoyl-CoA isomerase involved in fatty acid metabolism is disputed fatty acid beta-oxidation dodecenoyl-CoA delta-isomerase activity peroxisomal matrix
YBR103W YBR103W SIF2 hom Verified 0.243959712462456 0.403631011045624 no 1880 0.409381160264597 1353 NA FT CELL CYCLE|CHROMATIN ORGANIZATION|SIGNALING|GENE SILENCING NUCLEUS|CHROMOSOME WD40 repeat-containing subunit of the Set3C histone deacetylase complex, which represses early/middle sporulation genes; antagonizes telomeric silencing; binds specifically to the Sir4p N-terminus negative regulation of meiosis|negative regulation of chromatin silencing at telomere|regulation of transcription, DNA-dependent|histone deacetylation|positive regulation of stress-activated MAPK cascade molecular_function Rpd3L-Expanded complex|nucleus|Set3 complex
YML067C YML067C ERV41 hom Verified 0.242571047301794 0.404168856154682 no 1881 0.40629814309573 1316 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS Protein localized to COPII-coated vesicles, forms a complex with Erv46p; involved in the membrane fusion stage of transport; has homology to human ERGIC2 (PTX1) protein ER to Golgi vesicle-mediated transport molecular_function integral to endoplasmic reticulum membrane|integral to Golgi membrane|ER to Golgi transport vesicle
YOL038C-A_p YOL038C-A YOL038C-A hom Uncharacterized 0.242569085101394 0.404169616264655 no 1882 0.386798120959606 1246 NA Putative protein of unknown function; identified by SAGE analysis biological_process molecular_function cellular_component
YJL166W YJL166W QCR8 hom Verified 0.242442729836333 0.404218564064061 no 1883 0.397975521746652 1288 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p mitochondrial electron transport, ubiquinol to cytochrome c|aerobic respiration ubiquinol-cytochrome-c reductase activity mitochondrion|integral to membrane|mitochondrial respiratory chain complex III
YJR074W YJR074W MOG1 hom Verified 0.241858372348216 0.404444953331848 no 1884 0.397736216126094 1310 NA FT PROTEIN LOCALIZATION|RNA LOCALIZATION NUCLEUS Conserved nuclear protein that interacts with GTP-Gsp1p, which is a Ran homolog of the Ras GTPase family, and stimulates nucleotide release, involved in nuclear protein import, nucleotide release is inhibited by Yrb1p protein import into nucleus Ran GTPase binding nucleus
YKL181W YKL181W PRS1 hom Verified 0.241112788929894 0.404733850505967 no 1885 0.404850852979557 1346 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes fungal-type cell wall organization|5-phosphoribose 1-diphosphate biosynthetic process ribose phosphate diphosphokinase activity cytoplasm
YLR461W YLR461W PAU4 hom Verified 0.239367743399984 0.405410220043898 no 1886 0.409239950312866 1342 NA Member of the seripauperin multigene family encoded mainly in subtelomeric regions; active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme biological_process molecular_function cellular_component
YEL020C_p YEL020C YEL020C hom Uncharacterized 0.237990732515874 0.405944141053482 no 1887 0.40913334269407 1336 NA Protein of unknown function with low sequence identity to Pdc1p; mRNA identified as translated by ribosome profiling data biological_process molecular_function cytoplasm
YNL250W YNL250W RAD50 hom Verified 0.237966443380827 0.405953560475177 no 1888 0.322765225842721 1107 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE NUCLEUS|MITOCHONDRION Subunit of MRX complex with Mre11p and Xrs2p; complex is involved in processing double-strand DNA breaks in vegetative cells, initiation of meiotic DSBs, telomere maintenance, and nonhomologous end joining; forms nuclear foci upon DNA replication stress base-excision repair|meiotic DNA double-strand break processing|telomere maintenance via recombination|meiosis|meiotic DNA double-strand break formation|double-strand break repair via nonhomologous end joining|telomere maintenance|double-strand break repair via break-induced replication|negative regulation of endodeoxyribonuclease activity double-stranded DNA binding|single-stranded telomeric DNA binding|ATPase activity|double-stranded telomeric DNA binding|G-quadruplex DNA binding|telomeric DNA binding|adenylate kinase activity mitochondrion|nucleus|Mre11 complex
YLR437C YLR437C DIF1 hom Verified 0.237303252128029 0.406210769660224 no 1889 0.396243390307533 1311 NA FT NUCLEUS Protein that regulates the nuclear localization of ribonucleotide reductase Rnr2p and Rnr4p subunits; phosphorylated by Dun1p in response to DNA damage and degraded; N-terminal half has similarity to S. pombe Spd1 protein biological_process molecular_function cytoplasm
YKL008C YKL008C LAC1 hom Verified 0.237246001765836 0.406232975289135 no 1890 0.404109030024021 1340 NA FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Ceramide synthase component, involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lag1p replicative cell aging|ceramide biosynthetic process sphingosine N-acyltransferase activity integral to membrane|endoplasmic reticulum
YGR133W YGR133W PEX4 hom Verified 0.233140752510201 0.407826055373241 no 1891 0.401582491685593 1311 NA FT PROTEIN LOCALIZATION|SIGNALING|PEROXISOME ORGANIZATION Peroxisomal ubiquitin conjugating enzyme required for peroxisomal matrix protein import and peroxisome biogenesis peroxisome organization|protein import into peroxisome matrix, receptor recycling|protein autoubiquitination|protein monoubiquitination|protein polyubiquitination ubiquitin-protein ligase activity peroxisome
YIL148W YIL148W RPL40A hom Verified 0.23151060758635 0.408459072799518 no 1892 0.415680192256948 1375 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RESPONSE TO DNA DAMAGE|TRANSLATION NUCLEUS RIBOSOME Ubiquitin-ribosomal 60S subunit protein L40A fusion protein; cleaved to yield ubiquitin and ribosomal protein L40A; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; homologous to mammalian ribosomal protein L40, no bacterial homolog; RPL40A has a paralog, RPL40B, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress cytoplasmic translation|protein ubiquitination|ribosome biogenesis structural constituent of ribosome|protein tag cytosolic large ribosomal subunit
YOL119C YOL119C MCH4 hom Verified 0.230524234726482 0.408842216969441 no 1893 0.388210803868551 1262 NA Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport transport monocarboxylic acid transmembrane transporter activity|transporter activity fungal-type vacuole membrane|integral to membrane
YBR141C_p YBR141C YBR141C hom Uncharacterized 0.229279085579146 0.409326003916473 no 1894 0.39236341818055 1285 NA FT NUCLEUS Putative S-adenosylmethionine-dependent methyltransferase; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; YBR141C is not an essential gene biological_process S-adenosylmethionine-dependent methyltransferase activity nucleolus
YJR011C_p YJR011C YJR011C hom Uncharacterized 0.228649738598052 0.409570581321556 no 1895 0.406045933490484 1335 NA Putative protein of unknown function; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS biological_process molecular_function cellular_component
YCR095W-A_p YCR095W-A YCR095W-A hom Uncharacterized 0.227730526098403 0.40992786975415 no 1896 0.411059448366821 1354 NA Putative protein of unknown function biological_process molecular_function cellular_component
YML104C YML104C MDM1 hom Verified 0.225794700773447 0.410680549412156 no 1897 0.386991405768589 1256 NA FT MITOCHONDRION ORGANIZATION CYTOSKELETON Intermediate filament protein, required for nuclear and mitochondrial transmission to daughter buds; contains a Phox homology (PX) domain and specifically binds phosphatidylinositol 3-phosphate (PtdIns-3-P) nuclear migration|mitochondrion inheritance|mitochondrion organization structural constituent of cytoskeleton|phosphatidylinositol-3-phosphate binding intermediate filament|integral to membrane|cytoplasm
YLR149C YLR149C YLR149C hom Verified 0.225356793480825 0.41085086046328 no 1898 0.42903046829427 1398 NA Protein of unknown function; overexpression causes a cell cycle delay or arrest; null mutation results in a decrease in plasma membrane electron transport; YLR149C is not an essential gene; protein abundance increases in response to DNA replication stress biological_process molecular_function cellular_component
YOL055C YOL055C THI20 hom Verified 0.224602080532432 0.411144423105097 no 1899 0.404365718653634 1356 NA Trifunctional enzyme of thiamine biosynthesis, degradation and salvage; has hydroxymethylpyrimidine (HMP) kinase, HMP-phosphate (HMP-P) kinase and thiaminase activities; member of a gene family with THI21 and THI22; HMP and HMP-P kinase activity redundant with Thi21p thiamine biosynthetic process|thiamine catabolic process phosphomethylpyrimidine kinase activity|thiaminase activity|hydroxymethylpyrimidine kinase activity cytosol
YOR031W YOR031W CRS5 hom Verified 0.223598457042751 0.41153488218755 no 1900 0.410551806066895 1323 NA Copper-binding metallothionein, required for wild-type copper resistance response to metal ion copper ion binding cytoplasm
YLL016W YLL016W SDC25 hom pseudogene 0.223537216681262 0.411558710551922 no 1901 0.414868096171979 1386 NA FT SIGNALING Non-essential Ras guanine nucleotide exchange factor (GEF); localized to the membrane; expressed in poor nutrient conditions and on nonfermentable carbon sources; contains a stop codon in S288C, full-length gene includes YLL017W; SDC25 has a paralog, CDC25, that arose from the whole genome duplication Ras protein signal transduction Ras guanyl-nucleotide exchange factor activity cellular_component
YKL213C YKL213C DOA1 hom Verified 0.223376873297442 0.411621101026 no 1902 0.389701921015526 1259 NA FT RESPONSE TO DNA DAMAGE|PROTEOLYSIS NUCLEUS WD repeat protein required for ubiquitin-mediated protein degradation; forms a complex with Cdc48p; plays a role in controlling cellular ubiquitin concentration; also promotes efficient NHEJ in postdiauxic/stationary phase; protein increases in abundance and relocalizes from nucleus to nuclear periphery upon DNA replication stress double-strand break repair via nonhomologous end joining|ubiquitin-dependent protein catabolic process ubiquitin binding nucleus|cytoplasm
YOR374W YOR374W ALD4 hom Verified 0.223125417123391 0.411718948477005 no 1903 0.411842275623229 1349 NA FT KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM MITOCHONDRION Mitochondrial aldehyde dehydrogenase, required for growth on ethanol and conversion of acetaldehyde to acetate; phosphorylated; activity is K+ dependent; utilizes NADP+ or NAD+ equally as coenzymes; expression is glucose repressed NADPH regeneration|ethanol metabolic process|pyruvate metabolic process|acetate biosynthetic process aldehyde dehydrogenase [NAD(P)+] activity|aldehyde dehydrogenase (NAD) activity mitochondrial nucleoid|mitochondrion
YAR030C_d YAR030C YAR030C hom Dubious 0.222633238319592 0.411910482590798 no 1904 0.410945966837715 1352 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YAR029W and the verified gene PRM9 Unknown Unknown Unknown
YDR142C YDR142C PEX7 hom Verified 0.22202980640624 0.412145340106476 no 1905 0.438745385486779 1430 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|PEROXISOME ORGANIZATION Peroxisomal signal receptor for the N-terminal nonapeptide signal (PTS2) of peroxisomal matrix proteins; WD repeat protein; defects in human homolog cause lethal rhizomelic chondrodysplasia punctata (RCDP) protein import into peroxisome matrix, docking peroxisome matrix targeting signal-2 binding cytosol|peroxisome
YEL039C YEL039C CYC7 hom Verified 0.221335423735535 0.412415634865613 no 1906 0.420069546125828 1369 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Cytochrome c isoform 2, expressed under hypoxic conditions; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration; protein abundance increases in response to DNA replication stress; CYC7 has a paralog, CYC1, that arose from the whole genome duplication mitochondrial electron transport, cytochrome c to oxygen|mitochondrial electron transport, ubiquinol to cytochrome c electron carrier activity mitochondrion|mitochondrial intermembrane space
YCL035C YCL035C GRX1 hom Verified 0.220576214686053 0.412711211420982 no 1907 0.405710586446373 1329 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|RESPONSE TO OXIDATIVE STRESS NUCLEUS Glutathione-dependent disulfide oxidoreductase; hydroperoxide and superoxide-radical responsive, heat-stable, with active site cysteine pair; protects cells from oxidative damage; GRX1 has a paralog, GRX2, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress protein glutathionylation|cellular response to oxidative stress disulfide oxidoreductase activity|glutathione transferase activity|glutathione peroxidase activity nucleus|cytoplasm
YMR141C_d YMR141C YMR141C hom Dubious 0.219982337302209 0.412942455286059 no 1908 0.415112585396118 1366 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YLR224W_p YLR224W YLR224W hom Uncharacterized 0.219564496718657 0.413105172085531 no 1909 0.40575028824922 1339 NA FT PROTEOLYSIS F-box protein and component of SCF ubiquitin ligase complexes involved in ubiquitin-dependent protein catabolism; readily monoubiquitinated in vitro by SCF-Ubc4 complexes; YLR224W is not an essential gene SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|cellular response to methylmercury ubiquitin-protein ligase activity|protein binding, bridging SCF ubiquitin ligase complex
YDR476C_p YDR476C YDR476C hom Uncharacterized 0.219539264998678 0.413114998379835 no 1910 0.410529934770648 1322 NA FT ENDOPLASMIC RETICULUM Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDR476C is not an essential gene biological_process molecular_function endoplasmic reticulum
YML076C YML076C WAR1 hom Verified 0.219088060249519 0.413290725694166 no 1911 0.392704688453778 1325 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS|MITOCHONDRION Homodimeric Zn2Cys6 zinc finger transcription factor; binds to a weak acid response element to induce transcription of PDR12 and FUN34, encoding an acid transporter and a putative ammonia transporter, respectively response to acid sequence-specific DNA binding transcription factor activity mitochondrion|nucleus
YMR006C YMR006C PLB2 hom Verified 0.218385190297974 0.413564501754889 no 1912 0.371483674978747 1255 NA FT LIPID METABOLISM Phospholipase B (lysophospholipase) involved in phospholipid metabolism; displays transacylase activity in vitro; overproduction confers resistance to lysophosphatidylcholine glycerophospholipid metabolic process lysophospholipase activity extracellular region|fungal-type cell wall
YJL199C_d YJL199C MBB1 hom Dubious 0.218253009773027 0.413615992312982 no 1913 0.414427994202308 1356 NA Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; protein detected in large-scale protein-protein interaction studies Unknown Unknown Unknown
YDR093W YDR093W DNF2 hom Verified 0.217977144816285 0.413723459528499 no 1914 0.412526368477966 1366 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase intracellular protein transport|phospholipid translocation|endocytosis|establishment or maintenance of cell polarity phospholipid-translocating ATPase activity integral to membrane|plasma membrane
YHL045W_d YHL045W YHL045W hom Dubious 0.216769741879498 0.414193896881663 no 1915 0.411145561584599 1357 NA Putative protein of unknown function; not an essential gene Unknown Unknown Unknown
YGL157W YGL157W ARI1 hom Verified 0.21657041246411 0.414271572958138 no 1916 0.41660737789037 1391 NA FT OXIDATION-REDUCTION PROCESS NUCLEUS NADPH-dependent aldehyde reductase, utilizes aromatic and alophatic aldehyde substrates; member of the short-chain dehydrogenase/reductase superfamily biological_process oxidoreductase activity|carbonyl reductase (NADPH) activity nucleus|cytoplasm
YNL058C_p YNL058C YNL058C hom Uncharacterized 0.21436021171748 0.415133083461907 no 1917 0.395698038059703 1309 NA Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YNL058C is not an essential gene biological_process molecular_function fungal-type vacuole
YHL014C YHL014C YLF2 hom Verified 0.214326651573361 0.415146167971927 no 1918 0.417335554186319 1398 NA FT MITOCHONDRION Protein of unknown function, has weak similarity to E. coli GTP-binding protein gtp1; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process GTP binding mitochondrion
YDR003W YDR003W RCR2 hom Verified 0.214160018478354 0.415211136678842 no 1919 0.412498564672323 1345 NA FT VESICLE-MEDIATED TRANSPORT Vacuolar protein; presumably functions within the endosomal-vacuolar trafficking pathway, affecting events that determine whether plasma membrane proteins are degraded or routed to the plasma membrane; RCR2 has a paralog, RCR1, that arose from the whole genome duplication vesicle-mediated transport molecular_function vesicle|integral to membrane|fungal-type vacuole|cytoplasm
YNL128W YNL128W TEP1 hom Verified 0.213708901356192 0.415387034714147 no 1920 0.407402629132839 1341 NA FT CELL WALL ORG/BIOGENESIS PTEN homolog with no demonstrated inositol lipid phosphatase activity; plays a role in normal sporulation; homolog of human tumor suppressor gene PTEN/MMAC1/TEP1 and fission yeast ptn1 ascospore wall assembly|phosphatidylinositol dephosphorylation molecular_function cytoplasm
YBR013C_p YBR013C YBR013C hom Uncharacterized 0.213147784928072 0.415605846961961 no 1921 0.428177145493795 1406 NA Putative protein of unknown function, haploid deletion mutant exhibits synthetic phenotype with alpha-synuclein biological_process molecular_function cellular_component
YER057C YER057C HMF1 hom Verified 0.213030968524429 0.4156514038316 no 1922 0.402367805529506 1317 NA FT NUCLEUS Member of the p14.5 protein family with similarity to Mmf1p, functionally complements Mmf1p function when targeted to mitochondria; heat shock inducible; high-dosage growth inhibitor; forms a homotrimer in vitro biological_process molecular_function cytosol|nucleus|cytoplasm
YGL015C_p YGL015C YGL015C hom Uncharacterized 0.212586970562263 0.41582456756849 no 1923 0.408438229686424 1338 NA Putative protein of unknown function; null mutants accumulate cargo in the Golgi biological_process molecular_function cellular_component
YDL133W YDL133W SRF1 hom Verified 0.212496827892279 0.41585972612701 no 1924 0.466516957084636 1534 NA Regulator of phospholipase D (Spo14p); interacts with Spo14p and regulates its catalytic activity; capable of buffering the toxicity of C16:0 platelet activating factor, a lipid that accumulates intraneuronally in Alzheimer's patients positive regulation of catalytic activity molecular_function integral to membrane
YCL033C YCL033C MXR2 hom Verified 0.211185985710518 0.416371072965248 no 1925 0.414526966813599 1389 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|RESPONSE TO OXIDATIVE STRESS MITOCHONDRION Methionine-R-sulfoxide reductase, involved in the response to oxidative stress; protects iron-sulfur clusters from oxidative inactivation along with MXR1; involved in the regulation of lifespan cellular response to oxidative stress peptide-methionine (R)-S-oxide reductase activity mitochondrion
YBR028C YBR028C YPK3 hom Verified 0.210902895265161 0.416481522423745 no 1926 0.443126141772551 1451 NA FT PROTEIN PHOSPHORYLATION An AGC kinase phosphorylated by cAMP-dependent protein kinase (PKA) in a TORC1-dependent manner biological_process protein kinase activity cytoplasm
YKL171W YKL171W NNK1 hom Verified 0.210798957115745 0.416522076180241 no 1927 0.405858385825709 1325 NA FT PROTEOLYSIS|PROTEIN PHOSPHORYLATION Protein kinase; implicated in proteasome function; interacts with TORC1, Ure2 and Gdh2; overexpression leads to hypersensitivity to rapamycin and nuclear accumulation of Gln3; epitope-tagged protein localizes to the cytoplasm proteolysis|protein phosphorylation protein kinase activity cytoplasm
YJR018W_d YJR018W YJR018W hom Dubious 0.210230803702504 0.416743769430881 no 1928 0.39967194536215 1337 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YPR078C_p YPR078C YPR078C hom Uncharacterized 0.209363552994143 0.417082221373758 no 1929 0.416924726750283 1362 NA Putative protein of unknown function; possible role in DNA metabolism and/or in genome stability; expression is heat-inducible biological_process molecular_function cellular_component
YBL039W-B_p YBL039W-B YBL039W-B hom Uncharacterized 0.209194510642413 0.417148198749704 no 1930 0.402980538657338 1331 NA Putative protein of unknown function biological_process molecular_function cellular_component
YOR304C-A_p YOR304C-A YOR304C-A hom Uncharacterized 0.209008233094228 0.417220905739785 no 1931 0.420776267844284 1375 NA FT SITE OF POLARIZED GROWTH Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck biological_process molecular_function cellular bud|mating projection tip|cellular bud neck|cytoplasm
YBL061C YBL061C SKT5 hom Verified 0.208040348081064 0.417598731648942 no 1932 0.422117466585414 1405 NA FT CELL WALL ORG/BIOGENESIS|CELL DIVISION|CARBOHYDRATE METABOLISM SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON Activator of Chs3p (chitin synthase III) during vegetative growth; recruits Chs3p to the bud neck via interaction with Bni4p; SKT5 has a paralog, SHC1, that arose from the whole genome duplication fungal-type cell wall chitin biosynthetic process|response to osmotic stress|cytokinesis enzyme activator activity incipient cellular bud site|cellular bud neck septin ring|cellular bud neck
YDR257C YDR257C RKM4 hom Verified 0.208015389900936 0.417608475391586 no 1933 0.406766308517755 1335 NA FT NUCLEUS Ribosomal lysine methyltransferase specific for monomethylation of Rpl42ap and Rpl42bp (lysine 55); nuclear SET-domain containing protein peptidyl-lysine monomethylation protein-lysine N-methyltransferase activity nucleus
YJL004C YJL004C SYS1 hom Verified 0.207990206351672 0.41761830717024 no 1934 0.42199144893771 1393 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Integral membrane protein of the Golgi required for targeting of the Arf-like GTPase Arl3p to the Golgi; multicopy suppressor of ypt6 null mutation vesicle organization|Golgi to plasma membrane protein transport|Golgi to endosome transport molecular_function trans-Golgi network|integral to membrane|integral to Golgi membrane
YOL003C YOL003C PFA4 hom Verified 0.206889227595912 0.41804818482376 no 1935 0.418398140341275 1407 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases protein palmitoylation palmitoyltransferase activity integral to membrane|endoplasmic reticulum
YOR109W YOR109W INP53 hom Verified 0.206301276830818 0.418277790609983 no 1936 0.413167696153574 1357 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|MEMBRANE ORGANIZATION CYTOSKELETON Polyphosphatidylinositol phosphatase, dephosphorylates multiple phosphatidylinositols; involved in trans Golgi network-to-early endosome pathway; hyperosmotic stress causes translocation to actin patches; contains Sac1 and 5-ptase domains phosphatidylinositol dephosphorylation phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|phosphatidylinositol-3-phosphatase activity|phosphatidylinositol-4-phosphate phosphatase activity membrane|actin cortical patch|cytoplasm
YER141W YER141W COX15 hom Verified 0.206182254031949 0.41832427463452 no 1937 0.406037464147149 1342 NA FT OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM MITOCHONDRION Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase heme a biosynthetic process oxidoreductase activity, acting on NADH or NADPH, heme protein as acceptor mitochondrion|integral to membrane|mitochondrial inner membrane
YKR040C_d YKR040C YKR040C hom Dubious 0.206122852456994 0.418347474181911 no 1938 0.417169040538228 1370 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YKR041W Unknown Unknown Unknown
YLR318W YLR318W EST2 hom Verified 0.206032850909075 0.418382625225074 no 1939 0.41516856452539 1370 NA FT NUCLEUS|CHROMOSOME Reverse transcriptase subunit of the telomerase holoenzyme, essential for telomerase core catalytic activity, involved in other aspects of telomerase assembly and function; mutations in human homolog are associated with aplastic anemia telomere maintenance via telomerase|replicative cell aging telomerase activity|telomeric template RNA reverse transcriptase activity|telomeric DNA binding telomerase catalytic core complex|nucleolus|nucleus|telomerase holoenzyme complex
YDR185C YDR185C UPS3 hom Verified 0.204790716274148 0.418867820317816 no 1940 0.42104937172029 1415 NA FT MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial protein of unknown function; similar to Ups1p and Ups2p which are involved in regulation of mitochondrial cardiolipin and phosphatidylethanolamine levels; null is viable but interacts synthetically with ups1 and ups2 mutations mitochondrion morphogenesis molecular_function extrinsic to mitochondrial inner membrane|mitochondrion|mitochondrial intermembrane space
YGL056C YGL056C SDS23 hom Verified 0.203821559198293 0.419246472337735 no 1941 0.417322957400572 1394 NA FT CELL DIVISION NUCLEUS One of two S. cerevisiae homologs (Sds23p and Sds24p) of the S. pombe Sds23 protein, which is implicated in APC/cyclosome regulation; involved in cell separation during budding; SDS23 has a paralog, SDS24, that arose from the whole genome duplication cytokinetic cell separation molecular_function nucleus|cytoplasm
YKR034W YKR034W DAL80 hom Verified 0.203458540252837 0.419388323995913 no 1942 0.414680408328542 1352 NA FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS NUCLEUS Negative regulator of genes in multiple nitrogen degradation pathways; expression is regulated by nitrogen levels and by Gln3p; member of the GATA-binding family, forms homodimers and heterodimers with Gzf3p; DAL80 has a paralog, GZF3, that arose from the whole genome duplication nitrogen catabolite repression of transcription|negative regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity nucleus
YGL159W_p YGL159W YGL159W hom Uncharacterized 0.203215628322246 0.419483249026811 no 1943 0.426682797074633 1418 NA Putative protein of unknown function; deletion mutant has no detectable phenotype biological_process molecular_function cellular_component
YBR225W_p YBR225W YBR225W hom Uncharacterized 0.203011927126685 0.419562854914354 no 1944 0.403054973255675 1358 NA Putative protein of unknown function; non-essential gene identified in a screen for mutants affected in mannosylphophorylation of cell wall components biological_process molecular_function cellular_component
YLR370C YLR370C ARC18 hom Verified 0.202996576162945 0.419568854163747 no 1945 0.452499076129169 1493 NA FF|FT PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION MITOCHONDRION|CYTOSKELETON Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches mitochondrion inheritance|actin filament organization|establishment of mitochondrion localization molecular_function mitochondrion|Arp2/3 protein complex
YDR446W YDR446W ECM11 hom Verified 0.20134367689389 0.420214926281723 no 1946 0.400509166922397 1328 NA FT CELL CYCLE|CELL WALL ORG/BIOGENESIS NUCLEUS Non-essential protein apparently involved in meiosis, GFP fusion protein is present in discrete clusters in the nucleus throughout mitosis; may be involved in maintaining chromatin structure fungal-type cell wall organization|reciprocal meiotic recombination molecular_function nucleus
YMR276W YMR276W DSK2 hom Verified 0.199918684121644 0.420772088799567 no 1947 0.377642355439046 1235 NA FT CELL CYCLE|PROTEOLYSIS|CYTOSKELETON ORGANIZATION NUCLEUS Nuclear-enriched ubiquitin-like polyubiquitin-binding protein; required for spindle pole body (SPB) duplication and for transit through the G2/M phase of the cell cycle; involved in proteolysis; interacts with the proteasome; protein abundance increases in response to DNA replication stress ER-associated protein catabolic process|spindle pole body duplication associated with nuclear envelope protein binding, bridging nucleus
YDR259C YDR259C YAP6 hom Verified 0.199873006665031 0.420789951007239 no 1948 0.404663243607632 1339 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Basic leucine zipper (bZIP) transcription factor; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; overexpression increases sodium and lithium tolerance; computational analysis suggests a role in regulation of expression of genes involved in carbohydrate metabolism; YAP6 has a paralog, CIN5, that arose from the whole genome duplication negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding transcription factor recruiting transcription factor activity|sequence-specific DNA binding RNA polymerase II transcription factor activity|sequence-specific DNA binding nucleus
YPR149W YPR149W NCE102 hom Verified 0.199778549129057 0.420826889223067 no 1949 0.414843769843824 1372 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|PROTEIN PHOSPHORYLATION ENDOPLASMIC RETICULUM|MITOCHONDRION|PLASMA MEMBRANE Protein of unknown function; contains transmembrane domains; involved in secretion of proteins that lack classical secretory signal sequences; component of the detergent-insoluble glycolipid-enriched complexes (DIGs) eisosome assembly|protein secretion|negative regulation of protein phosphorylation|plasma membrane organization|establishment of protein localization to plasma membrane molecular_function mitochondrion|integral to membrane|membrane raft|endoplasmic reticulum|cellular bud membrane|plasma membrane|mating projection membrane|cytoplasm
YDR079W YDR079W PET100 hom Verified 0.199508552316777 0.420932477023961 no 1950 0.417193383721957 1380 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Chaperone that specifically facilitates the assembly of cytochrome c oxidase, integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme mitochondrial respiratory chain complex IV assembly|aerobic respiration unfolded protein binding mitochondrion|mitochondrial inner membrane|integral to mitochondrial inner membrane
YDR222W_p YDR222W YDR222W hom Uncharacterized 0.19918354154102 0.421059586709238 no 1951 0.445027489833337 1450 NA FT RESPONSE TO OXIDATIVE STRESS Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern biological_process molecular_function cytoplasm
YLR027C YLR027C AAT2 hom Verified 0.198936487890961 0.421156213355014 no 1952 0.44066715290012 1451 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Cytosolic aspartate aminotransferase, involved in nitrogen metabolism; localizes to peroxisomes in oleate-grown cells aspartate biosynthetic process L-aspartate:2-oxoglutarate aminotransferase activity cytosol|peroxisome
YPL003W YPL003W ULA1 hom Verified 0.198260637655477 0.421420573473897 no 1953 0.423640528838882 1411 NA Protein that acts together with Uba3p to activate Rub1p before its conjugation to proteins (neddylation), which may play a role in protein degradation protein neddylation NEDD8 activating enzyme activity cellular_component
YPL149W YPL149W ATG5 hom Verified 0.198033985134353 0.421509236981149 no 1954 0.411490309495065 1368 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS Conserved protein involved in autophagy and the Cvt pathway; undergoes conjugation with Atg12p to form a complex involved in Atg8p lipidation; conjugated Atg12p also forms a complex with Atg16p that is essential for autophagosome formation C-terminal protein lipidation|mitochondrion degradation|piecemeal microautophagy of nucleus|macroautophagy|CVT pathway Atg8 ligase activity cytosol|Atg12-Atg5-Atg16 complex|pre-autophagosomal structure|autophagic vacuole
YLR319C YLR319C BUD6 hom Verified 0.197849056996188 0.421581581402943 no 1955 0.430585876251915 1439 NA FT CELL CYCLE|CHROMATIN ORGANIZATION|SIGNALING|CELL DIVISION|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH|CYTOSKELETON Actin- and formin-interacting protein; stimulates actin cable nucleation by recruiting actin monomers to Bni1p; involved in polarized cell growth; isolated as bipolar budding mutant; potential Cdc28p substrate bipolar cellular bud site selection|positive regulation of formin-nucleated actin cable assembly|cellular bud site selection|Rho protein signal transduction|extrachromosomal circular DNA localization involved in cell aging|establishment of cell polarity|response to osmotic stress|cytokinesis cytoskeletal regulatory protein binding polarisome|actin cap|spindle pole body|mating projection tip
YDL123W YDL123W SNA4 hom Verified 0.196717243849174 0.422024407561951 no 1956 0.437825929366329 1481 NA Protein of unknown function, localized to the vacuolar outer membrane; predicted to be palmitoylated biological_process molecular_function fungal-type vacuole lumen|fungal-type vacuole membrane
YJL029C YJL029C VPS53 hom Verified 0.196659885760899 0.422046851759913 no 1957 0.377925619683081 1271 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT GOLGI APPARATUS Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; required for vacuolar protein sorting Golgi to vacuole transport|retrograde transport, endosome to Golgi molecular_function Golgi apparatus|GARP complex|cytoplasm
YGL192W YGL192W IME4 hom Verified 0.195685860718891 0.422428025981258 no 1958 0.434156794003584 1448 NA FT CELL CYCLE NUCLEUS Probable mRNA N6-adenosine methyltransferase required for entry into meiosis; transcribed in diploid cells; haploids repress IME4 transcription via production of antisense IME4 transcripts; antisense transcription is repressed in diploids meiosis|mRNA methylation mRNA (N6-adenosine)-methyltransferase activity cellular_component
YEL060C YEL060C PRB1 hom Verified 0.1955200169141 0.422492934418648 no 1959 0.419123485164609 1363 NA FT PROTEOLYSIS|RESPONSE TO NUTRIENT LEVELS Vacuolar proteinase B (yscB); serine protease of the subtilisin family; involved in protein degradation in the vacuole and required for full protein degradation during sporulation; activity inhibited by Pbi2p; protein abundance increases in response to DNA replication stress vacuolar protein catabolic process|sporulation resulting in formation of a cellular spore|cellular response to starvation serine-type endopeptidase activity fungal-type vacuole lumen|fungal-type vacuole
YMR255W YMR255W GFD1 hom Verified 0.195371822207211 0.422550937080784 no 1960 0.41958773093583 1408 NA FT PROTEIN LOCALIZATION|RNA LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS NUCLEAR PORE Coiled-coiled protein of unknown function; identified as a high-copy suppressor of a dbp5 mutation; protein abundance increases in response to DNA replication stress mRNA export from nucleus molecular_function integral to membrane|nuclear pore|cytoplasm
YDR375C YDR375C BCS1 hom Verified 0.194230749882365 0.42299760320024 no 1961 0.439470810395296 1464 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases protein insertion into mitochondrial membrane from inner side|chaperone-mediated protein complex assembly|mitochondrial respiratory chain complex III assembly protein transmembrane transporter activity|ATPase activity mitochondrion|mitochondrial inner membrane
YPL026C YPL026C SKS1 hom Verified 0.193814136324009 0.423160708854943 no 1962 0.377036352875791 1278 NA FT TRANSCRIPTION FROM RNA POL II|PROTEIN PHOSPHORYLATION NUCLEUS Putative serine/threonine protein kinase; involved in the adaptation to low concentrations of glucose independent of the SNF3 regulated pathway glucose transport|protein phosphorylation|response to glucose stimulus|positive regulation of transcription from RNA polymerase II promoter protein serine/threonine kinase activity|protein kinase activity nucleus|cytoplasm
YIL074C YIL074C SER33 hom Verified 0.193199634586762 0.42340131245118 no 1963 0.402477176769246 1349 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS 3-phosphoglycerate dehydrogenase; catalyzes the first step in serine and glycine biosynthesis; SER33 has a paralog, SER3, that arose from the whole genome duplication serine family amino acid biosynthetic process phosphoglycerate dehydrogenase activity cytoplasm
YHL026C_p YHL026C YHL026C hom Uncharacterized 0.192691421457234 0.423600321117664 no 1964 0.43176664086453 1417 NA Putative protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; YHL026C is not an essential gene; in 2005 the start site was moved 141 nt upstream (see Locus History) biological_process molecular_function cellular_component
YDR274C_d YDR274C YDR274C hom Dubious 0.19254876526557 0.423656186655708 no 1965 0.415087370478425 1341 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YPL145C YPL145C KES1 hom Verified 0.192353998697399 0.423732461596415 no 1966 0.418445173726817 1358 NA FT VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|MEMBRANE ORGANIZATION ENDOMEMBRANE SYSTEM|GOLGI APPARATUS One of seven members of the yeast oxysterol binding protein family; involved in negative regulation of Sec14p-dependent Golgi complex secretory functions, peripheral membrane protein that localizes to the Golgi complex; KES1 has a paralog, HES1, that arose from the whole genome duplication post-Golgi vesicle-mediated transport|positive regulation of phosphatase activity|maintenance of cell polarity|endocytosis|exocytosis|sterol transport phosphatidic acid binding|lipid binding|phosphatidylinositol-4,5-bisphosphate binding|oxysterol binding|sterol transporter activity|phosphatidylinositol-4-phosphate binding Golgi membrane|extrinsic to membrane|cytoplasm
YPL197C_d YPL197C YPL197C hom Dubious 0.191192673208675 0.424187321833684 no 1967 0.429545707542041 1408 NA Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the ribosomal gene RPB7B Unknown Unknown Unknown
YJL207C YJL207C LAA1 hom Verified 0.18967940826095 0.4247801788464 no 1968 0.428065954772885 1406 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS AP-1 accessory protein; colocalizes with clathrin to the late-Golgi apparatus; involved in TGN-endosome transport; physically interacts with AP-1; similar to the mammalian p200; may interact with ribosomes; YJL207C is a non-essential gene protein localization|retrograde transport, endosome to Golgi molecular_function AP-1 adaptor complex|ribosome|clathrin-coated vesicle
YOR003W YOR003W YSP3 hom Verified 0.1892198153709 0.424960268887939 no 1969 0.420979963878214 1411 NA FT PROTEOLYSIS Putative precursor to the subtilisin-like protease III protein catabolic process peptidase activity cellular_component
YLR102C YLR102C APC9 hom Verified 0.189162297677419 0.424982808120314 no 1970 0.419202342783673 1369 NA FT CELL CYCLE|CHROMATIN ORGANIZATION|CELL DIVISION NUCLEUS UBIQUITIN LIGASE COMPLEX Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition chromatin assembly|protein ubiquitination ubiquitin-protein ligase activity anaphase-promoting complex
YPL005W YPL005W AEP3 hom Verified 0.189073612292667 0.425017561393852 no 1971 0.40034067332536 1326 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Protein that may facilitate use of unformylated tRNA-Met in mitochondrial translation initiation; localized to the matrix face of the mitochondrial inner membrane; stabilizes the bicistronic AAP1-ATP6 mRNA mRNA metabolic process|mitochondrial translational initiation molecular_function mitochondrion|mitochondrial inner membrane|cytoplasm|extrinsic to membrane
YLR184W_d YLR184W YLR184W hom Dubious 0.18886242836789 0.425100320697923 no 1972 0.395214726043203 1316 NA Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YOR231W YOR231W MKK1 hom Verified 0.187975266660063 0.42544801994672 no 1973 0.429601746634019 1432 NA FT SIGNALING|PROTEIN PHOSPHORYLATION|PEROXISOME ORGANIZATION SITE OF POLARIZED GROWTH MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication signal transduction|peroxisome degradation|protein phosphorylation protein kinase activity|MAP kinase kinase activity cellular bud tip
YJL171C YJL171C YJL171C hom Verified 0.18796175247973 0.425453316916491 no 1974 0.394026297639383 1319 NA FT MITOCHONDRION|PLASMA MEMBRANE GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress biological_process molecular_function mitochondrion|fungal-type cell wall|plasma membrane
YJL200C YJL200C ACO2 hom Verified 0.18694238137239 0.425852904686618 no 1975 0.395909247619466 1280 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION Putative mitochondrial aconitase isozyme; similarity to Aco1p, an aconitase required for the TCA cycle; expression induced during growth on glucose, by amino acid starvation via Gcn4p, and repressed on ethanol biological_process aconitate hydratase activity mitochondrion
YLR148W YLR148W PEP3 hom Verified 0.186810627320397 0.425904557103827 no 1976 0.450316651382969 1500 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT Component of CORVET tethering complex; vacuolar peripheral membrane protein that promotes vesicular docking/fusion reactions in conjunction with SNARE proteins, required for vacuolar biogenesis regulation of SNARE complex assembly|regulation of vacuole fusion, non-autophagic|vacuole fusion, non-autophagic|late endosome to vacuole transport|vesicle docking involved in exocytosis|Golgi to endosome transport phosphatidylinositol binding|protein binding, bridging fungal-type vacuole membrane|HOPS complex|proteasome storage granule|CORVET complex|extrinsic to vacuolar membrane
YLL006W YLL006W MMM1 hom Verified 0.186544841143345 0.426008758894651 no 1977 0.443595749779376 1455 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION ER integral membrane protein, component of the ERMES complex that links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth mitochondrion organization|mitochondrial genome maintenance|protein import into mitochondrial outer membrane|phospholipid transport molecular_function mitochondrial outer membrane|mitochondrion|integral to endoplasmic reticulum membrane|ERMES complex
YGL118C_d YGL118C YGL118C hom Dubious 0.186000141190761 0.426222325303275 no 1978 0.428572956946598 1417 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YPR193C YPR193C HPA2 hom Verified 0.185948994381171 0.426242380099003 no 1979 0.414457495160192 1365 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CHROMATIN ORGANIZATION Tetrameric histone acetyltransferase with similarity to Gcn5p, Hat1p, Elp3p, and Hpa3p; acetylates histones H3 and H4 in vitro and exhibits autoacetylation activity protein homotetramerization|histone acetylation histone acetyltransferase activity|protein homodimerization activity cytoplasm
YNL154C YNL154C YCK2 hom Verified 0.185059701766717 0.426591104467426 no 1980 0.431921145290573 1445 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CELL DIVISION|PROTEIN PHOSPHORYLATION SITE OF POLARIZED GROWTH|PLASMA MEMBRANE Palmitoylated plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck1p in morphogenesis, proper septin assembly, endocytic trafficking; YCK2 has a paralog, YCK1, that arose from the whole genome duplication endocytosis|cell morphogenesis|protein phosphorylation|cytokinesis|response to glucose stimulus protein serine/threonine kinase activity|protein kinase activity plasma membrane|cellular bud neck|mating projection
YBR264C YBR264C YPT10 hom Verified 0.184696546734386 0.426733527442884 no 1981 0.42856512411863 1420 NA FT PROTEIN LOCALIZATION|SIGNALING PLASMA MEMBRANE Rab family GTP-binding protein that contains the PEST signal sequence specific for proteolytic enzymes; may be involved in vesicular transport; overexpression leads to accumulation of Golgi-like cisternae with budding vesicles Golgi organization GTPase activity|guanyl nucleotide binding cytoplasm
YPR013C_p YPR013C CMR3 hom Uncharacterized 0.183893199091618 0.427048620082926 no 1982 0.422666278308897 1408 NA Putative zinc finger protein; YPR013C is not an essential gene biological_process sequence-specific DNA binding cellular_component
YLR273C YLR273C PIG1 hom Verified 0.183871049389192 0.42705730839959 no 1983 0.407574036471883 1320 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY Putative targeting subunit for the type-1 protein phosphatase Glc7p that tethers it to the Gsy2p glycogen synthase regulation of glycogen biosynthetic process protein phosphatase type 1 regulator activity protein phosphatase type 1 complex
YGL141W YGL141W HUL5 hom Verified 0.183659225366133 0.42714039907632 no 1984 0.446463360182194 1461 NA FT PROTEOLYSIS NUCLEUS Multiubiquitin chain assembly factor (E4); proteasome processivity factor that elongates polyUb chains on substrates, opposing Ubp6p, a branched polyubiquitin protease; required for retrograde transport of misfolded proteins during ERAD ER-associated protein catabolic process|protein polyubiquitination ubiquitin-ubiquitin ligase activity proteasome complex|nucleus|cytoplasm
YBL002W YBL002W HTB2 hom Verified 0.183405080405827 0.427240094946407 no 1985 0.422091512113938 1384 NA FT CHROMATIN ORGANIZATION NUCLEUS|CHROMOSOME Histone H2B, core histone protein required for chromatin assembly and chromosome function; nearly identical to HTB1; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation chromatin assembly or disassembly DNA binding replication fork protection complex|nuclear nucleosome
YDR131C_p YDR131C YDR131C hom Uncharacterized 0.183271598344874 0.427292459090636 no 1986 0.418247734072169 1394 NA FT PROTEOLYSIS F-box protein, substrate-specific adaptor subunit that recruits substrates to a core ubiquitination complex SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ubiquitin-protein ligase activity|protein binding, bridging SCF ubiquitin ligase complex
YNL105W_d YNL105W RRT16 hom Dubious 0.18296444236941 0.427412959245761 no 1987 0.417510697383523 1397 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene INP52; identified in a screen for mutants with decreased levels of rDNA transcription Unknown Unknown Unknown
YBR023C YBR023C CHS3 hom Verified 0.18204767534003 0.427772655732976 no 1988 0.454201724587904 1517 NA FT CELL WALL ORG/BIOGENESIS|CELL DIVISION|CARBOHYDRATE METABOLISM SITE OF POLARIZED GROWTH Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan ascospore wall assembly|fungal-type cell wall chitin biosynthetic process|cytokinesis chitin synthase activity incipient cellular bud site|integral to membrane|chitosome|prospore membrane|cellular bud neck|mating projection tip|cytoplasm
YNL138W YNL138W SRV2 hom Verified 0.181804767153444 0.427867971612969 no 1989 0.499937712712476 1679 NA FT SIGNALING|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH|CYTOSKELETON CAP (cyclase-associated protein) subunit of adenylyl cyclase complex; N-terminus binds adenylyl cyclase and facilitates activation by RAS; C-terminus binds ADP-actin monomers, facilitating regulation of actin dynamics and cell morphogenesis cytoskeleton organization|Ras protein signal transduction cytoskeletal protein binding|adenylate cyclase binding mating projection tip|actin cortical patch
YOR366W_d YOR366W YOR366W hom Dubious 0.181633231511712 0.427935283822304 no 1990 0.435880343714665 1437 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR365C Unknown Unknown Unknown
YKL057C YKL057C NUP120 hom Verified 0.180921700003382 0.428214517891426 no 1991 0.443018578839688 1468 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RNA LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS NUCLEAR PORE Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport and NPC biogenesis and is involved in establishment of a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p; also plays roles in several processes that may require localization of genes or chromosomes at the nuclear periphery, including double-strand break repair, transcription and chromatin silencing; homologous to human NUP160 double-strand break repair|protein export from nucleus|ribosomal large subunit export from nucleus|maintenance of chromatin silencing at telomere|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|telomere tethering at nuclear periphery|nuclear pore distribution|mRNA export from nucleus in response to heat stress|mRNA export from nucleus|positive regulation of transcription, DNA-dependent|negative regulation of transcription from RNA polymerase II promoter|protein import into nucleus|positive regulation of transcription from RNA polymerase II promoter structural constituent of nuclear pore integral to membrane|nuclear pore|nuclear pore outer ring
YNL050C_p YNL050C YNL050C hom Uncharacterized 0.18077202026382 0.428273262924996 no 1992 0.438418679949842 1471 NA Putative protein of unknown function; YNL050c is not an essential gene biological_process molecular_function cellular_component
YOL128C YOL128C YGK3 hom Verified 0.179869135693944 0.428627653064107 no 1993 0.40565828808956 1331 NA FT PROTEOLYSIS|PROTEIN PHOSPHORYLATION Protein kinase related to mammalian glycogen synthase kinases of the GSK-3 family; GSK-3 homologs (Mck1p, Rim11p, Mrk1p, Ygk3p) are involved in control of Msn2p-dependent transcription of stress responsive genes and in protein degradation proteolysis|protein phosphorylation|response to stress protein serine/threonine kinase activity|protein kinase activity cellular_component
YNL233W YNL233W BNI4 hom Verified 0.179562842390518 0.428747888970006 no 1994 0.461947057716029 1520 NA FT PROTEIN LOCALIZATION|CELL DIVISION|CARBOHYDRATE METABOLISM SITE OF POLARIZED GROWTH|CYTOSKELETON Targeting subunit for Glc7p protein phosphatase, localized to the bud neck, required for localization of chitin synthase III to the bud neck via interaction with the chitin synthase III regulatory subunit Skt5p asymmetric protein localization|barrier septum assembly|chitin biosynthetic process protein binding incipient cellular bud site|cellular bud neck septin collar|cellular bud neck|septin ring
YLL039C YLL039C UBI4 hom Verified 0.179504667101274 0.42877072651663 no 1995 0.397839470263432 1314 NA FT RESPONSE TO DNA DAMAGE NUCLEUS Ubiquitin; becomes conjugated to proteins, marking them for selective degradation via the ubiquitin-26S proteasome system; essential for the cellular stress response; encoded as a polyubiquitin precursor comprised of 5 head-to-tail repeats; protein abundance increases in response to DNA replication stress protein deubiquitination|ascospore formation|protein monoubiquitination|protein polyubiquitination|protein ubiquitination|response to stress ATP-dependent protein binding|protein tag cytoplasm
YBR014C YBR014C GRX7 hom Verified 0.179023344711177 0.428959685686789 no 1996 0.414055799679468 1372 NA FT RESPONSE TO OXIDATIVE STRESS GOLGI APPARATUS Cis-golgi localized monothiol glutaredoxin; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; does not bind metal ions; GRX7 has a paralog, GRX6, that arose from the whole genome duplication cellular response to oxidative stress glutathione-disulfide reductase activity|protein homodimerization activity integral to membrane|Golgi apparatus|Golgi lumen|fungal-type vacuole|cis-Golgi network
YOR225W_d YOR225W YOR225W hom Dubious 0.178106970216003 0.429319484057735 no 1997 0.436954865796614 1457 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YPL223C YPL223C GRE1 hom Verified 0.176760508451917 0.429848255109106 no 1998 0.44407188159945 1466 NA Hydrophilin essential in dessication-rehydration process; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway biological_process molecular_function cytoplasm
YPL180W YPL180W TCO89 hom Verified 0.176649743315776 0.429891759470046 no 1999 0.436783043964957 1453 NA FT SIGNALING|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM PLASMA MEMBRANE Subunit of TORC1 (Tor1p or Tor2p-Kog1p-Lst8p-Tco89p), a complex that regulates growth in response to nutrient availability; cooperates with Ssd1p in the maintenance of cellular integrity; deletion strains are hypersensitive to rapamycin TOR signaling cascade|fungal-type cell wall organization|response to salt stress|regulation of cell growth|glycerol metabolic process molecular_function TORC1 complex|fungal-type vacuole membrane|extrinsic to internal side of plasma membrane|extrinsic to vacuolar membrane
YKR010C YKR010C TOF2 hom Verified 0.176550370208998 0.429930790196662 no 2000 0.423652078410419 1417 NA FT PROTEIN LOCALIZATION|CELL CYCLE|CHROMOSOME SEGREGATION|GENE SILENCING NUCLEUS|MITOCHONDRION Protein required for rDNA silencing and mitotic rDNA condensation; stimulates Cdc14p phosphatase activity and biphasic release to promote rDNA repeat segregation; required for condensin recruitment to the replication fork barrier site; TOF2 has a paralog, NET1, that arose from the whole genome duplication nucleolus organization|rDNA condensation|chromatin silencing at rDNA|protein localization to nucleolar rDNA repeats phosphatase activator activity mitochondrion|nucleolus
YGL191W YGL191W COX13 hom Verified 0.175908195678538 0.430183033267922 no 2001 0.413255508671733 1379 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Subunit VIa of cytochrome c oxidase; present in a subclass of cytochrome c oxidase complexes that may have a role in mimimizing generation of reactive oxygen species; not essential for cytochrome c oxidase activity but may modulate activity in response to ATP; required for assembly of Rcf2p into cytochrome c oxidase - cytochrome bc1 supercomplexes mitochondrial respiratory chain supercomplex assembly|aerobic respiration enzyme regulator activity|cytochrome-c oxidase activity mitochondrion|integral to membrane|mitochondrial respiratory chain complex IV
YDR246W-A_p YDR246W-A YDR246W-A hom Uncharacterized 0.175720766029089 0.430256660110752 no 2002 0.427326756314421 1405 NA Putative protein of unknown function; identified by fungal homology and RT-PCR biological_process molecular_function cellular_component
YDR315C YDR315C IPK1 hom Verified 0.175512268405484 0.430338565806048 no 2003 0.463741814862232 1532 NA FT NUCLEUS Inositol 1,3,4,5,6-pentakisphosphate 2-kinase, nuclear protein required for synthesis of 1,2,3,4,5,6-hexakisphosphate (phytate), which is integral to cell function; has 2 motifs conserved in other fungi; ipk1 gle1 double mutant is inviable nuclear-transcribed mRNA catabolic process, non-stop decay|inositol phosphate biosynthetic process inositol pentakisphosphate 2-kinase activity nucleus
YBL028C YBL028C YBL028C hom Verified 0.175290494508974 0.430425690209426 no 2004 0.444761931743019 1474 NA FT NUCLEUS Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis biological_process molecular_function ribosome|nucleolus|nucleus|preribosome, large subunit precursor
YIL173W YIL173W VTH1 hom Verified 0.175261232703338 0.430437186032476 no 2005 0.425250804890893 1391 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT GOLGI APPARATUS Putative membrane glycoprotein with strong similarity to Vth2p and Pep1p/Vps10p, may be involved in vacuolar protein sorting Golgi to vacuole transport signal sequence binding endosome|integral to membrane
YPR192W YPR192W AQY1 hom Verified 0.174264477442796 0.430828807474021 no 2006 0.417908174940796 1383 NA FT PLASMA MEMBRANE Spore-specific water channel that mediates the transport of water across cell membranes, developmentally controlled; may play a role in spore maturation, probably by allowing water outflow, may be involved in freeze tolerance ascospore formation|water transport water channel activity integral to membrane|plasma membrane
YJR019C YJR019C TES1 hom Verified 0.173871494068471 0.43098322790212 no 2007 0.432355861563687 1423 NA FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM MITOCHONDRION Peroxisomal acyl-CoA thioesterase likely to be involved in fatty acid oxidation rather than fatty acid synthesis; conserved protein also found in human peroxisomes; TES1 mRNA levels increase during growth on fatty acids fatty acid beta-oxidation|fatty acid oxidation acyl-CoA hydrolase activity mitochondrion|peroxisome
YLR341W YLR341W SPO77 hom Verified 0.173735861153555 0.431036526482074 no 2008 0.434379153876487 1430 NA FT CELL WALL ORG/BIOGENESIS Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis ascospore wall assembly|ascospore formation molecular_function intracellular
YOL155C YOL155C HPF1 hom Verified 0.173716403211244 0.431044172816814 no 2009 0.432839404807645 1443 NA FT CELL WALL ORG/BIOGENESIS Haze-protective mannoprotein that reduces the particle size of aggregated proteins in white wines fungal-type cell wall organization glucosidase activity fungal-type cell wall|extracellular region
YML035C YML035C AMD1 hom Verified 0.173710801388797 0.431046374154557 no 2010 0.425756866022469 1423 NA FT NUCLEOTIDE METABOLISM AMP deaminase; tetrameric enzyme that catalyzes the deamination of AMP to form IMP and ammonia; thought to be involved in regulation of intracellular purine (adenine, guanine, and inosine) nucleotide pools guanine salvage|purine nucleotide metabolic process AMP deaminase activity cytoplasm
YOR359W YOR359W VTS1 hom Verified 0.173429436856881 0.431156944205544 no 2011 0.449699730174348 1491 NA FT PROTEIN LOCALIZATION|RNA PROCESSING NUCLEUS Flap-structured DNA-binding and RNA-binding protein; stimulates deadenylation-dependent mRNA degradation mediated by the CCR4-NOT deadenylase complex; member of the Smaug (Smg) family of post-transcriptional regulators which bind RNA through a conserved sterile alpha motif (SAM) domain that interacts with Smg recognition element (SREs) containing transcripts; stimulates Dna2p endonuclease activity nuclear-transcribed mRNA catabolic process|positive regulation of endodeoxyribonuclease activity|nuclear-transcribed mRNA poly(A) tail shortening flap-structured DNA binding|RNA binding cytosol|nucleus|cytoplasmic mRNA processing body
YDL187C_d YDL187C YDL187C hom Dubious 0.171741701895581 0.431820299749372 no 2012 0.44551176181029 1462 NA Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YKL184W YKL184W SPE1 hom Verified 0.171224792081969 0.432023507045566 no 2013 0.436567339823732 1439 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM Ornithine decarboxylase, catalyzes the first step in polyamine biosynthesis; degraded in a proteasome-dependent manner in the presence of excess polyamines; deletion decreases lifespan, and increases necrotic cell death and ROS generation pantothenate biosynthetic process|putrescine biosynthetic process ornithine decarboxylase activity cytoplasm
YGR066C_p YGR066C YGR066C hom Uncharacterized 0.17107526528207 0.432082292293622 no 2014 0.449139350427219 1493 NA Putative protein of unknown function biological_process molecular_function cellular_component
YNL053W YNL053W MSG5 hom Verified 0.171062776515763 0.432087202218818 no 2015 0.438112221782777 1446 NA FT PROTEIN LOCALIZATION|CELL CYCLE|SIGNALING|CELL WALL ORG/BIOGENESIS|PROTEIN PHOSPHORYLATION NUCLEUS Dual-specificity protein phosphatase; exists in 2 isoforms; required for maintenance of a low level of signaling through the cell integrity pathway, adaptive response to pheromone; regulates and is regulated by Slt2p; dephosphorylates Fus3p adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion|regulation of fungal-type cell wall organization|inactivation of MAPK activity involved in cell wall biogenesis|regulation of MAPK export from nucleus|protein dephosphorylation|inactivation of MAPK activity involved in conjugation with cellular fusion protein tyrosine/serine/threonine phosphatase activity nucleus|cytoplasm
YPL183C YPL183C RTT10 hom Verified 0.170989852208413 0.432115872425363 no 2016 0.437045031879994 1448 NA FT VESICLE-MEDIATED TRANSPORT WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rrt2p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; evidence it interacts with Trm7p for 2'-O-methylation of N34 of substrate tRNAs; has a role in regulation of Ty1 transposition; human ortholog is WDR6 endocytic recycling molecular_function endosome|cytoplasm
YOL031C YOL031C SIL1 hom Verified 0.170653767561408 0.432248008792105 no 2017 0.425844988044881 1381 NA FT PROTEIN LOCALIZATION ENDOPLASMIC RETICULUM Nucleotide exchange factor for the endoplasmic reticulum (ER) lumenal Hsp70 chaperone Kar2p, required for protein translocation into the ER; homolog of Yarrowia lipolytica SLS1; GrpE-like protein SRP-dependent cotranslational protein targeting to membrane, translocation adenyl-nucleotide exchange factor activity endoplasmic reticulum
YCL029C YCL029C BIK1 hom Verified 0.169882301916154 0.432551349912424 no 2018 0.439242405990038 1478 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION NUCLEUS|SITE OF POLARIZED GROWTH|CHROMOSOME|CYTOSKELETON KINETOCHORE Microtubule-associated protein, component of the interface between microtubules and kinetochore, involved in sister chromatid separation; essential in polyploid cells but not in haploid or diploid cells; ortholog of mammalian CLIP-170 karyogamy involved in conjugation with cellular fusion|mitotic anaphase B|negative regulation of microtubule polymerization|nuclear migration involved in conjugation with cellular fusion|mitotic spindle organization in nucleus|mitotic spindle elongation microtubule binding|protein homodimerization activity spindle microtubule|microtubule plus end|spindle pole body|cell cortex|condensed nuclear chromosome kinetochore|mating projection tip|kinetochore|spindle
YMR039C YMR039C SUB1 hom Verified 0.169849421344723 0.432564279473042 no 2019 0.416458099363339 1350 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Transcriptional coactivator; facilitates elongation through factors that modify RNAP II; role in peroxide resistance involving Rad2p; role in the hyperosmotic stress response through polymerase recruitment at RNAP II and RNAP III genes; protein abundance increases in response to DNA replication stress termination of RNA polymerase II transcription|hyperosmotic response|RNA polymerase III transcriptional preinitiation complex assembly|positive regulation of transcription elongation from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter in response to stress|positive regulation of transcription from RNA polymerase III promoter transcription coactivator activity nucleus
YOR039W YOR039W CKB2 hom Verified 0.169663850253221 0.432637252571497 no 2020 0.423483408633133 1393 NA FF|FT RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION NUCLEUS Beta' regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerase regulation of transcription from RNA polymerase I promoter|protein phosphorylation|regulation of transcription from RNA polymerase III promoter|response to DNA damage stimulus protein serine/threonine kinase inhibitor activity|protein kinase regulator activity protein kinase CK2 complex|UTP-C complex|CURI complex
YCR071C YCR071C IMG2 hom Verified 0.169376755727343 0.432750152791171 no 2021 0.431909588443376 1417 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YNL206C YNL206C RTT106 hom Verified 0.169238205806874 0.432804639655535 no 2022 0.437050362194734 1446 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS|CHROMOSOME Histone chaperone, involved in regulation of chromatin structure in both transcribed and silenced chromosomal regions; affects transcriptional elongation; has a role in regulation of Ty1 transposition DNA replication-independent nucleosome assembly|negative regulation of transcription from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|DNA replication-dependent nucleosome assembly|heterochromatin assembly involved in chromatin silencing double-stranded DNA binding|histone binding nucleus
YLR342W-A_p YLR342W-A YLR342W-A hom Uncharacterized 0.168930570909707 0.432925626326087 no 2023 0.422037225994093 1412 NA Putative protein of unknown function biological_process molecular_function cellular_component
YPR006C YPR006C ICL2 hom Verified 0.168752627683191 0.43299561071978 no 2024 0.436243448484054 1432 NA FT KETONE METABOLISM|AMINO ACID METABOLISM MITOCHONDRION 2-methylisocitrate lyase of the mitochondrial matrix, functions in the methylcitrate cycle to catalyze the conversion of 2-methylisocitrate to succinate and pyruvate; ICL2 transcription is repressed by glucose and induced by ethanol threonine catabolic process|propionate metabolic process methylisocitrate lyase activity mitochondrion|mitochondrial matrix
YJR087W_d YJR087W YJR087W hom Dubious 0.168428585604462 0.433123060632524 no 2025 0.432959726867642 1445 NA Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified genes STE18 and ECM2 Unknown Unknown Unknown
YKL100C_p YKL100C YKL100C hom Uncharacterized 0.168216945841809 0.433206305026322 no 2026 0.421873759353342 1412 NA FT PROTEOLYSIS Putative protein of unknown function with similarity to a human minor histocompatibility antigen and signal peptide peptidases; YKL100C is not an essential gene biological_process molecular_function integral to membrane
YNL295W_p YNL295W YNL295W hom Uncharacterized 0.1680275449118 0.433280804719851 no 2027 0.412049184892056 1357 NA Putative protein of unknown function biological_process molecular_function cellular_component
YNL327W YNL327W EGT2 hom Verified 0.167855062287928 0.433348651764288 no 2028 0.443829090485158 1433 NA FT CELL CYCLE|CELL DIVISION Glycosylphosphatidylinositol (GPI)-anchored cell wall endoglucanase required for proper cell separation after cytokinesis, expression is activated by Swi5p and tightly regulated in a cell cycle-dependent manner cytokinesis cellulase activity fungal-type cell wall|cellular bud|cell septum
YJR103W YJR103W URA8 hom Verified 0.1676748595685 0.433419537651425 no 2029 0.420094539626164 1353 NA FT KETONE METABOLISM|LIPID METABOLISM|AMINO ACID METABOLISM|NUCLEOTIDE METABOLISM Minor CTP synthase isozyme (see also URA7); catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis; capable of forming cytoplasmic filaments termed cytoophidium, especially during conditions of glucose depletion; URA8 has a paralog, URA7, that arose from the whole genome duplication pyrimidine nucleobase biosynthetic process|CTP biosynthetic process|phospholipid biosynthetic process CTP synthase activity cytosol
YDR102C_d YDR102C YDR102C hom Dubious 0.167037723374291 0.433670183460814 no 2030 0.429648085739052 1422 NA Dubious open reading frame; homozygous diploid deletion strain exhibits high budding index Unknown Unknown Unknown
YGL007C-A_p YGL007C-A YGL007C-A hom Uncharacterized 0.16658158172539 0.433849643421555 no 2031 0.429093877815215 1401 NA Putative protein of unknown function, identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; deletion exhibits slow-growth phenotype; computationally predicted to have a role in cell budding biological_process molecular_function cellular_component
YMR145C YMR145C NDE1 hom Verified 0.166155836176671 0.43401715693916 no 2032 0.438707770222733 1430 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION Mitochondrial external NADH dehydrogenase, a type II NAD(P)H:quinone oxidoreductase that catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p provide cytosolic NADH to the mitochondrial respiratory chain glucose catabolic process to ethanol|NADH oxidation|chronological cell aging NADH dehydrogenase activity mitochondrion
YPL115C YPL115C BEM3 hom Verified 0.165811462636921 0.434152662559185 no 2033 0.4417688348715 1461 NA FT SIGNALING SITE OF POLARIZED GROWTH Rho GTPase activating protein (RhoGAP) involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assembly negative regulation of Rho protein signal transduction|establishment of cell polarity Rho GTPase activator activity|phosphatidylinositol-3-phosphate binding cell cortex|incipient cellular bud site|mating projection tip|cytoplasm|cellular bud tip
YBR146W YBR146W MRPS9 hom Verified 0.164353083362243 0.434726597653848 no 2034 0.450894225049466 1487 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the small subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial small ribosomal subunit
YOR213C YOR213C SAS5 hom Verified 0.162124670397479 0.435603839514386 no 2035 0.459383964556109 1530 NA FT CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS|CHROMOSOME HISTONE ACETYLTRANSFERASE Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; stimulates Sas2p HAT activity chromatin silencing at telomere acetyltransferase activity|histone acetyltransferase activity nuclear chromatin|SAS acetyltransferase complex|nuclear chromosome, telomeric region
YML027W YML027W YOX1 hom Verified 0.162034697959832 0.435639264944587 no 2036 0.436527766421147 1407 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE NUCLEUS|CHROMOSOME Homeobox transcriptional repressor; binds to Mcm1p and to early cell cycle boxes (ECBs) in the promoters of cell cycle-regulated genes expressed in M/G1 phase; expression is cell cycle-regulated; potential Cdc28p substrate; relocalizes from nucleus to cytoplasm upon DNA replication stress; YOX1 has a paralog, YHP1, that arose from the whole genome duplication negative regulation of transcription involved in G1 phase of mitotic cell cycle RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription nuclear chromatin|nucleus
YOR268C_p YOR268C YOR268C hom Uncharacterized 0.161930921308422 0.435680126238597 no 2037 0.415235811921155 1354 NA Putative protein of unknown function; sporulation is abnormal in homozygous diploid; YOR268C is not an essential gene biological_process molecular_function cellular_component
YHR151C YHR151C MTC6 hom Verified 0.161407099031407 0.435886387883143 no 2038 0.444519579912819 1454 NA Protein of unknown function; mtc6 is synthetically sick with cdc13-1 biological_process molecular_function cellular_component
YAL065C_p YAL065C YAL065C hom Uncharacterized 0.160649251738117 0.436184830689852 no 2039 0.420135707266246 1398 NA Putative protein of unknown function; has homology to FLO1; possible pseudogene biological_process molecular_function cellular_component
YIR020W-A_d YIR020W-A YIR020W-A hom Dubious 0.160464001832982 0.436257788257151 no 2040 0.446297005240767 1491 NA Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data Unknown Unknown Unknown
YPL037C YPL037C EGD1 hom Verified 0.159835586812883 0.436505295112667 no 2041 0.438256966043457 1434 NA FT PROTEIN LOCALIZATION NUCLEUS Subunit beta1 of the nascent polypeptide-associated complex (NAC) involved in protein targeting, associated with cytoplasmic ribosomes; enhances DNA binding of the Gal4p activator; homolog of human BTF3b 'de novo' cotranslational protein folding unfolded protein binding nascent polypeptide-associated complex
YMR068W YMR068W AVO2 hom Verified 0.159729017598566 0.436547270815547 no 2042 0.45723199433252 1502 NA FT SIGNALING|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION PLASMA MEMBRANE Component of a complex containing the Tor2p kinase and other proteins, which may have a role in regulation of cell growth fungal-type cell wall organization|TOR signaling cascade|regulation of cell growth|establishment or maintenance of actin cytoskeleton polarity molecular_function TORC2 complex|cytoplasm
YLR345W_p YLR345W YLR345W hom Uncharacterized 0.159577879625558 0.436606802578556 no 2043 0.427630589580588 1396 NA FT CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY Similar to 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase enzymes responsible for the metabolism of fructoso-2,6-bisphosphate; mRNA expression is repressed by the Rfx1p-Tup1p-Ssn6p repressor complex; YLR345W is not an essential gene regulation of glycolysis|fructose 2,6-bisphosphate metabolic process 6-phosphofructo-2-kinase activity cytoplasm
YDR018C_p YDR018C YDR018C hom Uncharacterized 0.158999425743882 0.436834663133038 no 2044 0.434318856252415 1449 NA FT LIPID METABOLISM Probable membrane protein with three predicted transmembrane domains; similar to C. elegans F55A11.5 and maize 1-acyl-glycerol-3-phosphate acyltransferase; YDR018C has a paralog, CST26, that arose from the whole genome duplication phospholipid biosynthetic process transferase activity, transferring acyl groups integral to membrane
YER050C YER050C RSM18 hom Verified 0.158201194283689 0.437149131351704 no 2045 0.433589564168937 1447 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial small ribosomal subunit
YJL157C YJL157C FAR1 hom Verified 0.157636156226788 0.437371755604674 no 2046 0.409319872312917 1373 NA FT PROTEIN LOCALIZATION|CELL CYCLE|SIGNALING|CELL DIVISION NUCLEUS|SITE OF POLARIZED GROWTH Cyclin-dependent kinase inhibitor; mediates cell cycle arrest in response to pheromone; also forms a complex with Cdc24p, Ste4p, and Ste18p that may specify the direction of polarized growth during mating; potential Cdc28p substrate; relocalizes from nucleus to cytoplasm upon DNA replication stress maintenance of protein location in nucleus|pheromone-dependent signal transduction involved in conjugation with cellular fusion|cell cycle arrest in response to pheromone cyclin-dependent protein kinase inhibitor activity nucleus|mating projection tip|membrane|cytoplasm
YEL012W YEL012W UBC8 hom Verified 0.157505144947439 0.437423376711327 no 2047 0.432872980683674 1416 NA FT KETONE METABOLISM|CARBOHYDRATE METABOLISM|PROTEOLYSIS Ubiquitin-conjugating enzyme that negatively regulates gluconeogenesis by mediating the glucose-induced ubiquitination of fructose-1,6-bisphosphatase (FBPase); cytoplasmic enzyme that catalyzes the ubiquitination of histones in vitro negative regulation of gluconeogenesis|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein polyubiquitination|protein monoubiquitination ubiquitin-protein ligase activity cytoplasm
YIL086C_d YIL086C YIL086C hom Dubious 0.157000706655356 0.43762214558928 no 2048 0.435037806104009 1425 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YBR275C YBR275C RIF1 hom Verified 0.155916473888553 0.438049429916032 no 2049 0.420982557314224 1372 NA FT CELL CYCLE|GENE SILENCING NUCLEUS|CHROMOSOME Protein that binds to the Rap1p C-terminus and acts synergistically with Rif2p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation telomere capping|telomere maintenance|chromatin silencing at silent mating-type cassette telomeric DNA binding nuclear telomere cap complex
YGR243W YGR243W FMP43 hom Verified 0.155524765045851 0.43820381589451 no 2050 0.437260978053814 1438 NA FT MITOCHONDRION Highly conserved subunit of the mitochondrial pyruvate carrier; a mitochondrial inner membrane complex comprised of Fmp37p/Mpc1p and either Mpc2p or Fmp43p/Mpc3p mediates mitochondrial pyruvate uptake; more highly expressed in glucose-containing minimal medium than in lactate-containing medium; expression regulated by osmotic and alkaline stresses; protein abundance increases in response to DNA replication stress mitochondrial pyruvate transport pyruvate transmembrane transporter activity mitochondrion|mitochondrial membrane
YDR230W_d YDR230W YDR230W hom Dubious 0.155177180457679 0.438340818857615 no 2051 0.431089931228181 1417 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20 Unknown Unknown Unknown
YJR109C YJR109C CPA2 hom Verified 0.155088775092188 0.438375665647112 no 2052 0.425671446204924 1402 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Large subunit of carbamoyl phosphate synthetase, which catalyzes a step in the synthesis of citrulline, an arginine precursor arginine biosynthetic process carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity carbamoyl-phosphate synthase complex
YGR052W_p YGR052W FMP48 hom Uncharacterized 0.154699083773111 0.438529276170824 no 2053 0.471074631687038 1567 NA FT PROTEIN PHOSPHORYLATION MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; induced by treatment with 8-methoxypsoralen and UVA irradiation protein phosphorylation protein kinase activity mitochondrion
YMR253C_p YMR253C YMR253C hom Uncharacterized 0.154697099366513 0.438530058418117 no 2054 0.439000200548465 1475 NA Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YMR253C is not an essential gene biological_process molecular_function integral to membrane|cytoplasm
YOR025W YOR025W HST3 hom Verified 0.154559088928154 0.438584462319335 no 2055 0.430333049755597 1416 NA FT KETONE METABOLISM|LIPID METABOLISM|CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst4p in telomeric silencing, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism short-chain fatty acid metabolic process|histone deacetylation|chromatin silencing at telomere histone deacetylase activity|DNA binding nucleus
YLR371W YLR371W ROM2 hom Verified 0.154035170504277 0.438791002225947 no 2056 0.484629053144144 1616 NA FF|FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING|CELL WALL ORG/BIOGENESIS|NUCLEOTIDE METABOLISM SITE OF POLARIZED GROWTH GDP/GTP exchange factor (GEF) for Rho1p and Rho2p; mutations are synthetically lethal with mutations in rom1, which also encodes a GEF; Rom2p localization to the bud surface is dependent on Ack1p regulation of fungal-type cell wall organization|positive regulation of endocytosis|establishment of cell polarity|small GTPase mediated signal transduction|negative regulation of cAMP-mediated signaling|activation of Rho GTPase activity phosphatidylinositol-4,5-bisphosphate binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity incipient cellular bud site|mating projection tip|cellular bud tip
YGR181W YGR181W TIM13 hom Verified 0.153392318909425 0.439044450914054 no 2057 0.425321722616171 1402 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial intermembrane space protein, forms a complex with Tim8p that delivers a subset of hydrophobic proteins to the TIM22 complex for insertion into the inner membrane protein import into mitochondrial inner membrane protein transporter activity mitochondrion|integral to membrane|mitochondrial intermembrane space protein transporter complex|mitochondrial intermembrane space
YPL147W YPL147W PXA1 hom Verified 0.152783866262836 0.439284360603651 no 2058 0.437089304833073 1420 NA FT NUCLEOTIDE METABOLISM Subunit of a heterodimeric peroxisomal ATP-binding cassette transporter complex (Pxa1p-Pxa2p), required for import of long-chain fatty acids into peroxisomes; similarity to human adrenoleukodystrophy transporter ABCD1 and ABCD2 and ALD-related proteins; mutations in ABCD1 cause X-linked adrenoleukodystrophy (X-ALD), a peroxisomal disorder fatty acid transport ATPase activity, coupled to transmembrane movement of substances integral to membrane|integral to peroxisomal membrane
YDR507C YDR507C GIN4 hom Verified 0.15166841524001 0.439724234956344 no 2059 0.461860269843308 1549 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION SITE OF POLARIZED GROWTH Protein kinase involved in bud growth and assembly of the septin ring; proposed to have kinase-dependent and kinase-independent activities; undergoes autophosphorylation; similar to Hsl1p; GIN4 has a paralog, KCC4, that arose from the whole genome duplication protein autophosphorylation|budding cell bud growth|protein phosphorylation|septin checkpoint|septin ring assembly protein kinase activity cellular bud neck
YMR136W YMR136W GAT2 hom Verified 0.151607650360475 0.439748199524269 no 2060 0.439465133761434 1414 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Protein containing GATA family zinc finger motifs; similar to Gln3p and Dal80p; expression repressed by leucine regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding RNA polymerase II transcription factor activity nucleus
YDR165W YDR165W TRM82 hom Verified 0.15151129829746 0.439786199485352 no 2061 0.466689946141712 1556 NA FT RNA PROCESSING NUCLEUS Catalytic subunit of a tRNA methyltransferase complex; Trm8p and Trm82p comprise an enzyme that catalyzes a methyl-transfer from S-adenosyl-l-methionine to the N(7) atom of guanine at position 46 in tRNA; Trm8 lacks catalytic activity if not bound to Trm82p tRNA methylation tRNA (guanine-N7-)-methyltransferase activity tRNA methyltransferase complex|nucleus
YJR073C YJR073C OPI3 hom Verified 0.151088524534764 0.439952942338455 no 2062 0.446743406561617 1484 NA FF|FT LIPID METABOLISM MITOCHONDRION Phospholipid methyltransferase (methylene-fatty-acyl-phospholipid synthase), catalyzes the last two steps in phosphatidylcholine biosynthesis phosphatidylcholine biosynthetic process phosphatidyl-N-dimethylethanolamine N-methyltransferase activity|phosphatidyl-N-methylethanolamine N-methyltransferase activity mitochondrion|integral to membrane
YEL065W YEL065W SIT1 hom Verified 0.15096609966748 0.440001228951288 no 2063 0.435271282737868 1440 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS Ferrioxamine B transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; transcription is induced during iron deprivation and diauxic shift; potentially phosphorylated by Cdc28p cellular iron ion homeostasis|siderophore transport|transmembrane transport siderophore uptake transmembrane transporter activity endosome|integral to membrane|cytoplasmic membrane-bounded vesicle
YGR039W_d YGR039W YGR039W hom Dubious 0.150897410852754 0.44002832147039 no 2064 0.461034345436052 1547 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the Autonomously Replicating Sequence ARS722 Unknown Unknown Unknown
YDL121C_p YDL121C YDL121C hom Uncharacterized 0.150879930858699 0.440035216044914 no 2065 0.443887096295411 1441 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDL121C is not an essential protein biological_process molecular_function endoplasmic reticulum
YOR105W_p YOR105W YOR105W hom Uncharacterized 0.150693093618449 0.440108910756753 no 2066 0.430012354219138 1426 NA Protein of unknown function; expressed at both mRNA and protein levels biological_process molecular_function cellular_component
YFR057W_p YFR057W YFR057W hom Uncharacterized 0.15053373844043 0.440171767285017 no 2067 0.450008596915562 1502 NA Putative protein of unknown function biological_process molecular_function cellular_component
YGR043C YGR043C NQM1 hom Verified 0.150249925153742 0.44028371917135 no 2068 0.438718029616316 1443 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS NUCLEUS Transaldolase of unknown function; transcription is repressed by Mot1p and induced by alpha-factor and during diauxic shift biological_process sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity nucleus
YDR014W YDR014W RAD61 hom Verified 0.149831503204396 0.44044877697262 no 2069 0.448364357197382 1500 NA FT CELL CYCLE|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME Subunit of a complex (Scc3p, Pds5p, Rad61p) that inhibits sister chromatid cohesion; inhibited by Eco1p-acetylated cohesin subunits Smc3p and Mcd1p; related to the human Wapl protein that controls the association of cohesin with chromatin mitotic sister chromatid cohesion molecular_function nuclear cohesin complex
YNL051W YNL051W COG5 hom Verified 0.149734313214387 0.440487117662428 no 2070 0.457928080717394 1515 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments intra-Golgi vesicle-mediated transport|CVT pathway molecular_function Golgi transport complex
YBL070C_d YBL070C YBL070C hom Dubious 0.149626080509966 0.440529815273222 no 2071 0.444651322448156 1470 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YGL166W YGL166W CUP2 hom Verified 0.14939745817236 0.440620008654085 no 2072 0.448344247811843 1463 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Copper-binding transcription factor; activates transcription of the metallothionein genes CUP1-1 and CUP1-2 in response to elevated copper concentrations; CUP2 has a paralog, HAA1, that arose from the whole genome duplication regulation of transcription from RNA polymerase II promoter|response to copper ion RNA polymerase II core promoter proximal region sequence-specific DNA binding|copper ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity|copper ion binding nucleus
YBL029C-A YBL029C-A YBL029C-A hom Verified 0.147706913344068 0.441287037714606 no 2073 0.451517675804725 1496 NA FT PLASMA MEMBRANE Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; protein abundance increases in response to DNA replication stress; has potential orthologs in Saccharomyces species and in Yarrowia lipolytica biological_process molecular_function plasma membrane
YOR065W YOR065W CYT1 hom Verified 0.145514308172038 0.44215240984874 no 2074 0.432370359047756 1403 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex oxidative phosphorylation|mitochondrial electron transport, ubiquinol to cytochrome c electron transporter, transferring electrons within CoQH2-cytochrome c reductase complex activity mitochondrion|mitochondrial respiratory chain|integral to membrane|mitochondrial inner membrane|mitochondrial respiratory chain complex III
YOR185C YOR185C GSP2 hom Verified 0.144805871684338 0.44243207307957 no 2075 0.459329881528262 1518 NA FT PROTEIN LOCALIZATION|SIGNALING|NUCLEOTIDE METABOLISM NUCLEUS GTP binding protein (mammalian Ranp homolog); involved in the maintenance of nuclear organization, RNA processing and transport; interacts with Kap121p, Kap123p and Pdr6p (karyophilin betas); Gsp1p homolog that is not required for viability; protein abundance increases in response to DNA replication stress nucleus organization GTPase activity integral to membrane|nucleus
YBL043W YBL043W ECM13 hom Verified 0.144731956726831 0.44246125349141 no 2076 0.423463184072263 1377 NA FT CELL WALL ORG/BIOGENESIS Non-essential protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation; ECM13 has a paralog, YJR115W, that arose from the whole genome duplication fungal-type cell wall organization molecular_function cellular_component
YPR116W YPR116W RRG8 hom Verified 0.144467033211575 0.442565843509697 no 2077 0.431054571487591 1415 NA FT MITOCHONDRION ORGANIZATION MITOCHONDRION Putative protein of unknown function, required for mitochondrial genome maintenance; null mutation results in a decrease in plasma membrane electron transport mitochondrial genome maintenance molecular_function mitochondrion
YGL071W YGL071W AFT1 hom Verified 0.144143643776955 0.442693520903823 no 2078 0.469251077123662 1542 NA FF|FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|ION HOMEOSTASIS|ION HOMEOSTASIS|RESPONSE TO NUTRIENT LEVELS|CHROMOSOME SEGREGATION NUCLEUS Transcription factor involved in iron utilization and homeostasis; binds consensus site PyPuCACCCPu and activates transcription in response to changes in iron availability; in iron-replete conditions activity is negatively regulated by Grx3p, Grx4p, and Fra2p, which regulate Aft1p translocation from the nucleus to the cytoplasm; AFT1 has a paralog, AFT2, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress positive regulation of transcription from RNA polymerase II promoter in response to iron ion starvation|meiotic chromosome segregation|positive regulation of iron ion transport|establishment of mitotic sister chromatid cohesion|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity|core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding nucleus|cytoplasm
YCR010C YCR010C ADY2 hom Verified 0.143123439949078 0.443096346556503 no 2079 0.448467453833588 1481 NA FT CELL CYCLE|ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION|PLASMA MEMBRANE Acetate transporter required for normal sporulation; phosphorylated in mitochondria; ADY2 has a paralog, ATO2, that arose from the whole genome duplication nitrogen utilization|ammonium transport|acetate transport|transmembrane transport acetate transmembrane transporter activity|ammonium transmembrane transporter activity mitochondrion|integral to membrane|plasma membrane
YHR175W-A_p YHR175W-A YHR175W-A hom Uncharacterized 0.14295598411057 0.443162471825082 no 2080 0.437845659842522 1427 NA Putative protein of unknown function; identified by fungal homology and RT-PCR biological_process molecular_function cellular_component
YGR084C YGR084C MRP13 hom Verified 0.142488395699404 0.443347122369887 no 2081 0.439172481426187 1470 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the small subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial small ribosomal subunit
YER046W-A_d YER046W-A YER046W-A hom Dubious 0.141235666417587 0.443841885370035 no 2082 0.442293429499721 1462 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YMR041C YMR041C ARA2 hom Verified 0.14107459785671 0.443905505453508 no 2083 0.434488431458154 1425 NA FT OXIDATION-REDUCTION PROCESS NAD-dependent arabinose dehydrogenase, involved in biosynthesis of dehydro-D-arabinono-1,4-lactone; similar to plant L-galactose dehydrogenase dehydro-D-arabinono-1,4-lactone biosynthetic process D-arabinose 1-dehydrogenase [NAD(P)+] activity cellular_component
YGR234W YGR234W YHB1 hom Verified 0.140957780138348 0.443951647907663 no 2084 0.440179558456472 1435 NA FT OXIDATION-REDUCTION PROCESS MITOCHONDRION Nitric oxide oxidoreductase; flavohemoglobin involved in nitric oxide detoxification; plays a role in the oxidative and nitrosative stress responses; protein increases in abundance and relocalizes from nucleus to cytoplasmic foci upon DNA replication stress response to stress nitric oxide reductase activity cytosol|mitochondrion|mitochondrial matrix|cytoplasm
YLR338W_d YLR338W OPI9 hom Dubious 0.14047677382527 0.444141651157467 no 2085 0.458922105953794 1525 NA FF Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF VRP1/YLR337C Unknown Unknown Unknown
YML108W YML108W YML108W hom Verified 0.140267619437128 0.444224273651369 no 2086 0.432266289253492 1424 NA FT NUCLEUS Protein of unknown function; structure defines a new subfamily of the split beta-alpha-beta sandwiches; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YML108W is not an essential gene; relative distribution to the nucleus increases upon DNA replication stress biological_process molecular_function nucleus|cytoplasm
YKL016C YKL016C ATP7 hom Verified 0.139535889675694 0.444513348735742 no 2087 0.448855688844727 1487 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS MITOCHONDRION Subunit d of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis protein complex assembly|ATP synthesis coupled proton transport hydrogen ion transporting ATP synthase activity, rotational mechanism|ATPase activity|proton-transporting ATPase activity, rotational mechanism mitochondrion|mitochondrial proton-transporting ATP synthase, stator stalk|integral to membrane|mitochondrial proton-transporting ATP synthase complex
YDL089W YDL089W NUR1 hom Verified 0.138722084835764 0.444834882829854 no 2088 0.447585979865313 1490 NA FT ENDOMEMBRANE SYSTEM|NUCLEUS Protein of unknown function; interacts with Csm1p, Lrs4p; required for rDNA repeat stability; null mutant causes increase in unequal sister-chromatid exchange; GFP-fusion protein localizes to the nuclear periphery, possible Cdc28p substrate maintenance of rDNA molecular_function nuclear periphery
YJL102W YJL102W MEF2 hom Verified 0.13870099841717 0.444843214552088 no 2089 0.449381252058883 1494 NA FT TRANSLATION|NUCLEOTIDE METABOLISM MITOCHONDRION Mitochondrial elongation factor involved in translational elongation translational elongation translation elongation factor activity mitochondrion
YLR248W YLR248W RCK2 hom Verified 0.137577073295752 0.445287338030736 no 2090 0.451846753547129 1503 NA FT CELL CYCLE|SIGNALING|PROTEIN PHOSPHORYLATION|RESPONSE TO OXIDATIVE STRESS Protein kinase involved in response to oxidative and osmotic stress; identified as suppressor of S. pombe cell cycle checkpoint mutations; similar to CaM (calmodulin) kinases; RCK2 has a paralog, RCK1, that arose from the whole genome duplication cellular response to oxidative stress|protein phosphorylation|osmosensory signaling pathway|regulation of meiosis protein serine/threonine kinase activity|protein kinase activity cytoplasm
YPR174C YPR174C YPR174C hom Verified 0.136890451556085 0.445558693169487 no 2091 0.438367138865911 1467 NA FT ENDOMEMBRANE SYSTEM|NUCLEUS|CYTOSKELETON Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nuclear periphery; potential Cdc28p substrate; binds phosphatidylinositols and phosphatidylethanolamine in a large-scale study; relative distribution to foci at the nuclear periphery increases upon DNA replication stress; YPR174C has a paralog, NBP1, that arose from the whole genome duplication biological_process molecular_function nuclear envelope|spindle pole body
YHL042W_p YHL042W YHL042W hom Uncharacterized 0.136599273809276 0.44567377526861 no 2092 0.414750691741119 1359 NA Putative protein of unknown function; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins biological_process molecular_function cellular_component
YNL129W YNL129W NRK1 hom Verified 0.134507078264916 0.446500807153575 no 2093 0.442861828324859 1484 NA FT NUCLEOTIDE METABOLISM|COFACTOR METABOLISM Nicotinamide riboside kinase, catalyzes the phosphorylation of nicotinamide riboside and nicotinic acid riboside in salvage pathways for NAD+ biosynthesis nicotinamide riboside metabolic process|NAD biosynthesis via nicotinamide riboside salvage pathway|NAD biosynthetic process nicotinic acid riboside kinase activity|ribosylnicotinamide kinase activity cytoplasm
YMR228W YMR228W MTF1 hom Verified 0.133942909145518 0.446723859692204 no 2094 0.432013975857738 1420 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation transcription initiation from mitochondrial promoter mitochondrial RNA polymerase binding promoter specificity activity mitochondrion|mitochondrial DNA-directed RNA polymerase complex|mitochondrial matrix|mitochondrial intermembrane space
YLR443W YLR443W ECM7 hom Verified 0.133201115644116 0.447017164276954 no 2095 0.447066704340616 1483 NA FT ION HOMEOSTASIS|CELL WALL ORG/BIOGENESIS|ION HOMEOSTASIS Non-essential putative integral membrane protein with a role in calcium uptake; mutant has cell wall defects and Ca+ uptake deficiencies; transcription is induced under conditions of zinc deficiency fungal-type cell wall organization|calcium ion transport molecular_function integral to membrane
YOL004W YOL004W SIN3 hom Verified 0.13314019504794 0.447041253524213 no 2096 0.450901186212437 1476 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|CELL DIVISION|GENE SILENCING NUCLEUS|CHROMOSOME Component of the Sin3p-Rpd3p histone deacetylase complex, involved in transcriptional repression and activation of diverse processes, including mating-type switching and meiosis; involved in the maintenance of chromosomal integrity positive regulation of transcription from RNA polymerase II promoter in response to heat stress|negative regulation of chromatin silencing at rDNA|histone deacetylation|negative regulation of chromatin silencing at silent mating-type cassette|negative regulation of transcription from RNA polymerase I promoter|negative regulation of transcription during meiosis|regulation of DNA-dependent DNA replication initiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of chromatin silencing at telomere|double-strand break repair via nonhomologous end joining|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription involved in G2/M-phase of mitotic cell cycle transcription coactivator activity|transcription corepressor activity Sin3-type complex|Rpd3S complex|Rpd3L-Expanded complex|Rpd3L complex
YOR219C YOR219C STE13 hom Verified 0.131917223490388 0.447524882655492 no 2097 0.461047687388245 1523 NA FT PROTEOLYSIS GOLGI APPARATUS Dipeptidyl aminopeptidase, Golgi integral membrane protein that cleaves on the carboxyl side of repeating -X-Ala- sequences, required for maturation of alpha factor, transcription is induced by a-factor peptide pheromone maturation aminopeptidase activity trans-Golgi network
YBR278W YBR278W DPB3 hom Verified 0.131165520199924 0.447822185578839 no 2098 0.453130872450159 1497 NA FT RESPONSE TO DNA DAMAGE|GENE SILENCING NUCLEUS|CHROMOSOME Third-largest subunit of DNA polymerase II (DNA polymerase epsilon); required to maintain fidelity of chromosomal replication and also for inheritance of telomeric silencing; stabilizes the interaction of Pol epsilon with primer-template DNA, positively affecting the processivity of the polymerase and exonuclease activities of Pol epsilon; mRNA abundance peaks at the G1/S boundary of the cell cycle; DPB3 has a paralog, DLS1, that arose from the whole genome duplication DNA-dependent DNA replication|chromatin silencing at telomere double-stranded DNA binding|single-stranded DNA binding|DNA-directed DNA polymerase activity epsilon DNA polymerase complex
YBL011W YBL011W SCT1 hom Verified 0.130559321031666 0.448061962155157 no 2099 0.439487554984959 1448 NA FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Glycerol 3-phosphate/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase of the glycerolipid biosynthesis pathway, prefers 16-carbon fatty acids, similar to Gpt2p, gene is constitutively transcribed phospholipid biosynthetic process glycerol-3-phosphate O-acyltransferase activity|glycerone-phosphate O-acyltransferase activity integral to membrane|endoplasmic reticulum
YER046W YER046W SPO73 hom Verified 0.130356815638103 0.448142065557742 no 2100 0.442531577781909 1458 NA FT CELL WALL ORG/BIOGENESIS Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensible for both nuclear divisions during meiosis ascospore wall assembly|ascospore formation molecular_function cytosol
YKL032C YKL032C IXR1 hom Verified 0.13032619166181 0.448154179417772 no 2101 0.48975849677849 1637 NA FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME Protein that binds DNA containing intrastrand cross-links formed by cisplatin, contains two HMG (high mobility group box) domains, which confer the ability to bend cisplatin-modified DNA; mediates aerobic transcriptional repression of COX5b DNA repair|cellular response to hypoxia|negative regulation of transcription from RNA polymerase II promoter damaged DNA binding|sequence-specific DNA binding nuclear chromatin
YJL210W YJL210W PEX2 hom Verified 0.13030923436907 0.448160887198163 no 2102 0.444367826989735 1466 NA FT PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION RING-finger peroxin and E3 ubiquitin ligase, peroxisomal membrane protein with a C-terminal zinc-binding RING domain, forms translocation subcomplex with Pex10p and Pex12p which functions in peroxisomal matrix protein import protein import into peroxisome matrix ubiquitin-protein ligase activity|protein binding peroxisomal membrane
YPL269W YPL269W KAR9 hom Verified 0.130266867027254 0.448177646472619 no 2103 0.492612568282303 1647 NA FT NUCLEUS|SITE OF POLARIZED GROWTH|CYTOSKELETON Karyogamy protein required for correct positioning of the mitotic spindle and for orienting cytoplasmic microtubules, localizes at the shmoo tip in mating cells and at the tip of the growing bud in small-budded cells through anaphase nuclear migration along microtubule|establishment of spindle localization molecular_function cell cortex|spindle pole body|mating projection tip
YKL160W YKL160W ELF1 hom Verified 0.130256278610102 0.448181834953501 no 2104 0.43386529921235 1412 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION NUCLEUS Transcription elongation factor that contains a conserved zinc finger domain; implicated in the maintenance of proper chromatin structure in actively transcribed regions; deletion inhibits Brome mosaic virus (BMV) gene expression regulation of transcription by chromatin organization|transcription elongation from RNA polymerase II promoter RNA polymerase II core binding transcription elongation factor complex|nucleus
YIL100W_d YIL100W YIL100W hom Dubious 0.130018540257921 0.448275879098546 no 2105 0.450658065168772 1469 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the dubious ORF YIL100C-A Unknown Unknown Unknown
YGR097W YGR097W ASK10 hom Verified 0.129993091021872 0.448285946437687 no 2106 0.459091296258482 1528 NA FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO OXIDATIVE STRESS NUCLEUS RNA POL II, HOLOENZYME Component of RNA polymerase II holoenzyme; phosphorylated in response to oxidative stress; has a role in destruction of Ssn8p; proposed to function in activation of the glycerol channel Fps1p; ASK10 has a paralog, RGC1, that arose from the whole genome duplication cellular protein catabolic process|cellular response to oxidative stress|positive regulation of transcription from RNA polymerase II promoter|positive regulation of glycerol transport molecular_function DNA-directed RNA polymerase II, holoenzyme|cytoplasm
YGR209C YGR209C TRX2 hom Verified 0.1293939938392 0.448522949976114 no 2107 0.438037222365135 1451 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|RESPONSE TO OXIDATIVE STRESS ENDOMEMBRANE SYSTEM|NUCLEUS|GOLGI APPARATUS Cytoplasmic thioredoxin isoenzyme; part of the thioredoxin system which protects cells against oxidative and reductive stress; forms LMA1 complex with Pbi2p; acts as a cofactor for Tsa1p; required for ER-Golgi transport and vacuole inheritance; protein abundance increases in response to DNA replication stress vacuole inheritance|regulation of DNA replication|cell redox homeostasis|protein deglutathionylation|sulfate assimilation|retrograde vesicle-mediated transport, Golgi to ER|cellular response to oxidative stress|ER to Golgi vesicle-mediated transport|vacuole fusion, non-autophagic disulfide oxidoreductase activity cytosol|fungal-type vacuole
YLR232W_d YLR232W YLR232W hom Dubious 0.129294093336572 0.448562472520084 no 2108 0.443582098125776 1489 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene BNA5 Unknown Unknown Unknown
YCR030C YCR030C SYP1 hom Verified 0.129244200780315 0.448582211157971 no 2109 0.432681326202571 1394 NA FT CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH Protein of unknown function that is involved in endocytic site formation; may regulate assembly and disassembly of the septin ring; colocalizes and interacts with septin subunits; potential role in actin cytoskeletal organization septin cytoskeleton organization|actin cortical patch assembly molecular_function mating projection base|mating projection tip|cellular bud neck|cellular bud tip
YDR133C_d YDR133C YDR133C hom Dubious 0.128151333502315 0.449014606326432 no 2110 0.445969504728921 1451 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR134C Unknown Unknown Unknown
YJR098C_p YJR098C YJR098C hom Uncharacterized 0.127704090239521 0.449191576528325 no 2111 0.43536336012337 1416 NA FT LIPID METABOLISM MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process molecular_function mitochondrion|cytoplasm
YJL137C YJL137C GLG2 hom Verified 0.127444782973375 0.449294186750583 no 2112 0.427869407000521 1407 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY Glycogenin glucosyltransferase; self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; similar to mammalian glycogenin; GLG2 has a paralog, GLG1, that arose from the whole genome duplication glycogen biosynthetic process glycogenin glucosyltransferase activity cytoplasm
YKL143W YKL143W LTV1 hom Verified 0.126462960993356 0.449682733227095 no 2113 0.414009144947372 1353 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RESPONSE TO OXIDATIVE STRESS NUCLEUS Component of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; required for ribosomal small subunit export from nucleus; required for growth at low temperature ribosomal small subunit biogenesis|cellular response to oxidative stress|response to osmotic stress|ribosomal small subunit export from nucleus molecular_function preribosome, small subunit precursor|EGO complex|nucleus|late endosome membrane|cytoplasm
YFL036W YFL036W RPO41 hom Verified 0.125428533593036 0.450092149972005 no 2114 0.455056861484692 1510 NA FT MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial RNA polymerase; single subunit enzyme similar to those of T3 and T7 bacteriophages; requires a specificity subunit encoded by MTF1 for promoter recognition; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation transcription from mitochondrial promoter|mitochondrial genome maintenance DNA-directed RNA polymerase activity mitochondrial nucleoid|mitochondrion|mitochondrial DNA-directed RNA polymerase complex|mitochondrial matrix
YMR034C_p YMR034C YMR034C hom Uncharacterized 0.125142606220659 0.450205326756669 no 2115 0.453222071795933 1514 NA Putative transporter, member of the SLC10 carrier family; identified in a transposon mutagenesis screen as a gene involved in azole resistance; YMR034C is not an essential gene biological_process sterol transporter activity integral to membrane
YGL244W YGL244W RTF1 hom Verified 0.123264697731458 0.450948747365091 no 2116 0.464849383737827 1542 NA FF|FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION|GENE SILENCING NUCLEUS|CHROMOSOME RNA POL II, HOLOENZYME Subunit of RNAPII-associated chromatin remodeling Paf1 complex; regulates gene expression by directing cotranscriptional histone modification, influences transcription and chromatin structure through several independent functional domains; directly or indirectly regulates DNA-binding properties of Spt15p and relative activities of different TATA elements; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay mRNA 3'-end processing|snoRNA transcription from an RNA polymerase II promoter|regulation of chromatin silencing at telomere|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|regulation of histone H3-K4 methylation|regulation of transcription-coupled nucleotide-excision repair|negative regulation of transcription from RNA polymerase II promoter|recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex|global genome nucleotide-excision repair|snoRNA 3'-end processing|Unknown|transcription elongation from RNA polymerase II promoter RNA binding|RNA polymerase II transcription factor binding transcription factor activity nucleus|transcriptionally active chromatin|Cdc73/Paf1 complex
YFL040W_p YFL040W YFL040W hom Uncharacterized 0.123139209722002 0.45099843133367 no 2117 0.455925041148105 1490 NA Putative transporter, member of the sugar porter family; YFL040W is not an essential gene transmembrane transport substrate-specific transmembrane transporter activity integral to membrane|membrane
YHL023C YHL023C NPR3 hom Verified 0.122767380729553 0.451145652612862 no 2118 0.468901093862216 1559 NA FT CELL CYCLE|SIGNALING|RESPONSE TO NUTRIENT LEVELS Subunit of SEA (Seh1-associated), Npr2/3, and Iml1p complexes; Npr2/3 complex mediates downregulation of TORC1 activity upon amino acid limitation; SEA complex is a coatomer-related complex that associates dynamically with the vacuole; Iml1p complex (Iml1p-Npr2p-Npr3p) is required for non-nitrogen-starvation (NNS)-induced autophagy; required for Npr2p phosphorylation and Iml1p-Npr2p interaction; null mutant shows delayed meiotic DNA replication and double-strand break repair meiosis|regulation of TOR signaling cascade|cellular response to amino acid starvation molecular_function Seh1-associated complex|extrinsic to fungal-type vacuolar membrane
YJR058C YJR058C APS2 hom Verified 0.122522036454235 0.451242797450039 no 2119 0.432576235985565 1418 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|PLASMA MEMBRANE Small subunit of the clathrin-associated adaptor complex AP-2, which is involved in protein sorting at the plasma membrane; related to the sigma subunit of the mammalian plasma membrane clathrin-associated protein (AP-2) complex vesicle-mediated transport molecular_function AP-2 adaptor complex
YPR158W YPR158W CUR1 hom Verified 0.122483982960497 0.451257865112262 no 2120 0.471449160723513 1567 NA FT NUCLEUS Sorting factor, central regulator of spatial protein quality control; physically and functionally interacts with chaperones to promote sorting and deposition of misfolded proteins into cytosolic compartments; involved in destabilization of [URE3] prions; CUR1 has a paralog, BTN2, that arose from the whole genome duplication cellular response to stress|protein localization to nucleus chaperone binding nucleus
YFL052W_p YFL052W YFL052W hom Uncharacterized 0.120126583879953 0.452191436990362 no 2121 0.433058872312151 1448 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Putative zinc cluster protein that contains a DNA binding domain; computational analysis suggests a role as a transcription factor; null mutant is sensitive to Calcofluor White, low osmolarity, and heat, suggesting a role for YFL052Wp in cell wall integrity biological_process DNA binding cellular_component
YOR163W YOR163W DDP1 hom Verified 0.119668626754542 0.452372826971864 no 2122 0.443745171464845 1466 NA FT CARBOHYDRATE METABOLISM NUCLEUS Polyphosphate phosphatase; hydrolyzes diphosphorylated inositol polyphosphates and diadenosine polyphosphates; high specificity for diadenosine hexa- and pentaphosphates; contains endopolyphosphatase activity with a high affinity for polyphosphates, an activity also observed for its human DIPP homologs; possesses mRNA decapping activity; nudix hydrolase family member; protein abundance increases in response to DNA replication stress polyphosphate catabolic process|inositol phosphate dephosphorylation|diadenosine polyphosphate catabolic process diphosphoinositol-polyphosphate diphosphatase activity|endopolyphosphatase activity|bis(5'-adenosyl)-pentaphosphatase activity|bis(5'-adenosyl)-hexaphosphatase activity nucleus|cytoplasm
YBR107C YBR107C IML3 hom Verified 0.119446015429471 0.452461003587774 no 2123 0.451083039783352 1502 NA FT PROTEIN LOCALIZATION|CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME KINETOCHORE Outer kinetochore protein and component of the Ctf19 complex; involved in the establishment of pericentromeric cohesion during mitosis; prevents non-disjunction of sister chromatids during meiosis II; required for localization of Sgo1p to pericentric sites during meiosis I; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-L and fission yeast fta1 establishment of meiotic sister chromatid cohesion|ascospore formation|protein localization to chromosome, centromeric region|meiotic sister chromatid segregation|maintenance of meiotic sister chromatid cohesion|establishment of mitotic sister chromatid cohesion molecular_function condensed nuclear chromosome outer kinetochore
YDL069C YDL069C CBS1 hom Verified 0.119311096771214 0.452514446173393 no 2124 0.456154952006846 1493 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial translational activator of the COB mRNA; membrane protein that interacts with translating ribosomes, acts on the COB mRNA 5'-untranslated leader mitochondrial respiratory chain complex III biogenesis|positive regulation of mitochondrial translation translation regulator activity extrinsic to mitochond