strainid	orf	gene	zyg	qualifier	SGTC_787|4152-0075.score	SGTC_787|4152-0075.expt.zyg.pval	SGTC_787|4152-0075.expt.zyg.significant	SGTC_787|4152-0075.expt.zyg.rank	strain.pval	strain.rank	clearance	Fclass	Fterms.BP	Fterms.CC	Fterms.complex	description	GO_process	GO_function	GO_component
YHR098C	YHR098C	SFB3	hom	Verified	9.2100106488902	1.6304628911652e-20	yes	1	3.83029940512772e-17	6	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS|SITE OF POLARIZED GROWTH		Component of the Sec23p-Sfb3p heterodimer of the COPII vesicle coat, required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sec24p and Sfb2p	cargo loading into COPII-coated vesicle	signal sequence binding	COPII vesicle coat|mating projection tip
YOR350C	YOR350C	MNE1	hom	Verified	5.66635327269147	7.29343139231918e-09	yes	2	6.85728946899582e-09	3	NA	FT	RNA PROCESSING	MITOCHONDRION		Mitochondrial matrix protein involved in splicing Group I aI5-beta intron from COX1 mRNA	Group I intron splicing	molecular_function	mitochondrion|ribonucleoprotein complex|mitochondrial matrix
YOL122C	YOL122C	SMF1	hom	Verified	5.5572625578137	1.37019195264694e-08	yes	3	3.25993071634641e-09	4	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Divalent metal ion transporter with a broad specificity for di-valent and tri-valent metals; post-translationally regulated by levels of metal ions; member of the Nramp family of metal transport proteins	copper ion transport|cellular copper ion homeostasis|manganese ion transport|cadmium ion transport|cellular manganese ion homeostasis|cellular cadmium ion homeostasis|iron ion transport	solute:hydrogen symporter activity|inorganic cation transmembrane transporter activity	integral to membrane|plasma membrane
YPR063C_p	YPR063C	YPR063C	hom	Uncharacterized	5.33856841838539	4.68416768548388e-08	yes	4	2.3091573950668e-07	4	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		ER-localized protein of unknown function	biological_process	molecular_function	endoplasmic reticulum
YGL197W	YGL197W	MDS3	hom	Verified	5.14555422114108	1.33366071610833e-07	yes	5	1.75619019320837e-06	5	NA	FT	CELL CYCLE|SIGNALING	MITOCHONDRION		Putative component of the TOR regulatory pathway; negative regulator of early meiotic gene expression; required, with Pmd1p, for growth under alkaline conditions; has an N-terminal kelch-like domain	TOR signaling cascade|negative regulation of sporulation resulting in formation of a cellular spore	molecular_function	mitochondrion|cytoplasm
YLR403W	YLR403W	SFP1	hom	Verified	4.94770254572214	3.7547273458648e-07	yes	6	3.25076207507418e-07	20	NA	FT	TRANSCRIPTION FROM RNA POL II|RIBOSOME BIOGENESIS	NUCLEUS		Regulates transcription of ribosomal protein and biogenesis genes; regulates response to nutrients and stress, G2/M transitions during mitotic cell cycle and DNA-damage response, and modulates cell size; regulated by TORC1 and Mrs6p; sequence of zinc finger, ChIP localization data, and protein-binding microarray (PBM) data, and computational analyses suggest it binds DNA directly at highly active RP genes and indirectly through Rap1p at others; can form the [ISP+] prion	positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter|regulation of cell size|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II transcription factor binding transcription factor activity	nucleus|cytoplasm
YDR200C	YDR200C	VPS64	hom	Verified	4.88686621006941	5.12268324422061e-07	yes	7	2.88492425170036e-06	18	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|SIGNALING|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein required for cytoplasm to vacuole targeting of proteins; forms a complex with Far3p and Far7p to Far11p involved in recovery from pheromone-induced cell cycle arrest; mutant has increased aneuploidy tolerance	re-entry into mitotic cell cycle after pheromone arrest|protein targeting to vacuole	molecular_function	endoplasmic reticulum membrane|cytoplasm
YLR406C-A_p	YLR406C-A	YLR406C-A	hom	Uncharacterized	4.8392260775179	6.51728535130352e-07	yes	8	1.06961628105097e-06	6	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YBR106W	YBR106W	PHO88	hom	Verified	4.63013538942322	1.82713358896627e-06	yes	9	0.000326481079661491	92	NA	FF|FT	ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Probable membrane protein, involved in phosphate transport; pho88 pho86 double null mutant exhibits enhanced synthesis of repressible acid phosphatase at high inorganic phosphate concentrations	phosphate ion transport	molecular_function	mitochondrion|membrane
YPR100W	YPR100W	MRPL51	hom	Verified	4.62745531737938	1.85093032910135e-06	yes	10	2.15972793918052e-05	28	NA	FT	TRANSLATION|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation|aerobic respiration	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YCR002C	YCR002C	CDC10	hom	Verified	4.59400099847504	2.17413647470051e-06	yes	11	1.53825408102122e-05	10	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Component of the septin ring, required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins between mother and daughter cells; N-terminus interacts with phosphatidylinositol-4,5-bisphosphate; protein abundance increases under DNA damage stress	sporulation|maintenance of cell polarity|exit from mitosis|cell cycle cytokinesis|septin ring assembly	protein complex scaffold|structural molecule activity|GTP binding|GTPase activity|1-phosphatidylinositol binding	spindle microtubule|ascospore-type prospore|septin complex|prospore membrane|mating projection base|meiotic spindle|septin filament array|cellular bud neck septin ring|mating projection tip
YPR164W	YPR164W	MMS1	hom	Verified	4.55648943525198	2.60078270538474e-06	yes	12	2.67345724464641e-06	16	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS	UBIQUITIN LIGASE COMPLEX	Subunit of an E3 ubiquitin ligase complex involved in replication repair; stabilizes protein components of the replication fork such as the fork-pausing complex and leading strand polymerase, preventing fork collapse and promoting efficient recovery during replication stress; regulates Ty1 transposition; involved with Rtt101p in nonfunctional rRNA decay	replication fork processing|negative regulation of transposition, RNA-mediated|recombinational repair|nonfunctional rRNA decay	molecular_function	Cul8-RING ubiquitin ligase complex
YNL230C	YNL230C	ELA1	hom	Verified	4.49984780061488	3.4001066735593e-06	yes	13	6.56533538880621e-06	6	NA	FT	PROTEOLYSIS	NUCLEUS	UBIQUITIN LIGASE COMPLEX	Elongin A; F-box protein that forms a heterodimer with Elc1p and is required for ubiquitin-dependent degradation of the RNA Polymerase II subunit Rpo21p; subunit of the Elongin-Cullin-Socs (ECS) ligase complex	protein ubiquitination involved in ubiquitin-dependent protein catabolic process	ubiquitin-protein ligase activity	elongin complex|Cul3-RING ubiquitin ligase complex
YDR500C	YDR500C	RPL37B	hom	Verified	4.46644487395544	3.9765071476643e-06	yes	14	5.50300799640459e-06	8	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L37B; protein abundance increases in response to DNA replication stress; homologous to mammalian ribosomal protein L37, no bacterial homolog; RPL37B has a paralog, RPL37A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YLR415C_p	YLR415C	YLR415C	hom	Uncharacterized	4.40329673906091	5.33090875372475e-06	yes	15	6.4023191043715e-06	5	NA	FT		MITOCHONDRION		Putative protein of unknown function; YLR415C is not an essential gene	biological_process	molecular_function	cellular_component
YER002W	YER002W	NOP16	hom	Verified	4.37098167744675	6.18445865694723e-06	yes	16	1.9278965265507e-05	6	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis	ribosomal large subunit biogenesis	molecular_function	nucleolus|nucleus|preribosome, large subunit precursor
YGL163C	YGL163C	RAD54	hom	Verified	4.3485801821987	6.85108610984259e-06	yes	17	9.22557930741962e-05	40	NA	FF|FT	CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE	NUCLEUS		DNA-dependent ATPase that stimulates strand exchange; modifies the topology of double-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; member of the SWI/SNF family; forms nuclear foci upon DNA replication stress	positive regulation of endodeoxyribonuclease activity|DNA geometric change|heteroduplex formation|telomere maintenance via recombination|double-strand break repair via synthesis-dependent strand annealing|chromatin remodeling|double-strand break repair via single-strand annealing	DNA-dependent ATPase activity|DNA translocase activity	nucleus
YNL077W	YNL077W	APJ1	hom	Verified	4.24283453193304	1.10357087856303e-05	yes	18	0.000113348666860289	18	NA	FT		NUCLEUS|MITOCHONDRION		Chaperone with a role in SUMO-mediated protein degradation; member of the DnaJ-like family; conserved across eukaryotes; overexpression interferes with propagation of the [Psi+] prion; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; forms nuclear foci upon DNA replication stress	biological_process	unfolded protein binding	mitochondrion|nucleus|cytoplasm
YJR107W_p	YJR107W	YJR107W	hom	Uncharacterized	4.22481356815004	1.19569332508087e-05	yes	19	7.65723114081429e-06	5	NA	FT	LIPID METABOLISM			Putative lipase	biological_process	lipase activity	cellular_component
YCL042W_p	YCL042W	YCL042W	hom	Uncharacterized	4.21196862333809	1.26577357432033e-05	yes	20	5.95500032795698e-05	12	NA					Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm	biological_process	molecular_function	cytoplasm
YGL014W	YGL014W	PUF4	hom	Verified	4.2117053959322	1.2672497644367e-05	yes	21	8.07263258963245e-05	11	NA	FT	PROTEIN LOCALIZATION|CHROMATIN ORGANIZATION|TRANSLATION|GENE SILENCING			Member of the PUF protein family, which is defined by the presence of Pumilio homology domains that confer RNA binding activity; preferentially binds mRNAs encoding nucleolar ribosomal RNA-processing factors	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|negative regulation of translation|protein localization|negative regulation of chromatin silencing involved in replicative cell aging	mRNA binding	cytoplasm
YOL115W	YOL115W	PAP2	hom	Verified	3.97727938557563	3.4854122775634e-05	yes	22	7.12950613451166e-05	21	NA	FT	CELL CYCLE|RNA PROCESSING|RESPONSE TO DNA DAMAGE|CELL DIVISION	NUCLEUS		Non-canonical poly(A) polymerase, involved in nuclear RNA degradation as a component of the TRAMP complex; catalyzes polyadenylation of hypomodified tRNAs, and snoRNA and rRNA precursors; overlapping but non-redundant functions with Trf5p	polyadenylation-dependent mRNA catabolic process|nuclear polyadenylation-dependent CUT catabolic process|base-excision repair|nuclear polyadenylation-dependent tRNA catabolic process|nuclear polyadenylation-dependent snoRNA catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|nuclear polyadenylation-dependent snRNA catabolic process|ncRNA polyadenylation|histone mRNA catabolic process|nuclear polyadenylation-dependent mRNA catabolic process|nuclear polyadenylation-dependent antisense transcript catabolic process|U4 snRNA 3'-end processing|nuclear mRNA surveillance of mRNA 3'-end processing|polyadenylation-dependent snoRNA 3'-end processing|snoRNA polyadenylation|tRNA modification	5'-deoxyribose-5-phosphate lyase activity|polynucleotide adenylyltransferase activity	nucleolus|nucleus|TRAMP complex
YCR022C_d	YCR022C	YCR022C	hom	Dubious	3.94653393310998	3.96453443927024e-05	yes	23	7.66841040536568e-06	5	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR022C is not an essential gene	Unknown	Unknown	Unknown
YMR207C	YMR207C	HFA1	hom	Verified	3.87822615350776	5.26104404478595e-05	yes	24	3.2233724053316e-05	11	NA	FT	KETONE METABOLISM|LIPID METABOLISM	MITOCHONDRION		Mitochondrial acetyl-coenzyme A carboxylase; catalyzes the production of malonyl-CoA in mitochondrial fatty acid biosynthesis; relocalizes from mitochondrion to cytoplasm upon DNA replication stress	fatty acid biosynthetic process	acetyl-CoA carboxylase activity	mitochondrion
YBL044W_p	YBL044W	YBL044W	hom	Uncharacterized	3.80000460674355	7.23466990122739e-05	yes	25	8.06698171157172e-05	13	NA					Putative protein of unknown function; YBL044W is not an essential protein	biological_process	molecular_function	cellular_component
YLR446W_p	YLR446W	YLR446W	hom	Uncharacterized	3.75444833404079	8.68618364607745e-05	yes	26	5.14666391426013e-05	19	NA	FT	CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY			Putative hexokinase; transcript is upregulated during sporulation and the unfolded protein response; YLR446W is not an essential gene	biological_process	molecular_function	cellular_component
YBR250W	YBR250W	SPO23	hom	Verified	3.7023215704559	0.000106817800382311	yes	27	0.00013903667217346	8	NA	FT	CELL CYCLE			Protein of unknown function; associates with meiosis-specific protein Spo1p	meiosis	molecular_function	cellular_component
YCR101C_p	YCR101C	YCR101C	hom	Uncharacterized	3.69008128898954	0.00011209120164952	yes	28	0.000118495772563007	22	NA					Putative protein of unknown function; localizes to the membrane fraction; YCR101C is not an essential gene	biological_process	molecular_function	integral to membrane|membrane
YGR239C	YGR239C	PEX21	hom	Verified	3.6548998875403	0.000128641177237924	yes	29	0.000189522907094418	10	NA	FT	PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION			Peroxin required for peroxisomal matrix protein targeting; acts on proteins containing the PTS2 targeting sequence; interacts with Pex7p; partially redundant with Pex18p; relative distribution to cytoplasmic foci increases upon DNA replication stress	protein import into peroxisome matrix|positive regulation of protein binding	protein binding	cytosol|peroxisome
YLR370C	YLR370C	ARC18	hom	Verified	3.65468477256142	0.00012874908059152	yes	30	0.00336323302114421	108	NA	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION	MITOCHONDRION|CYTOSKELETON		Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches	mitochondrion inheritance|actin filament organization|establishment of mitochondrion localization	molecular_function	mitochondrion|Arp2/3 protein complex
YDL020C	YDL020C	RPN4	hom	Verified	3.60552752576147	0.000155759733719857	yes	31	0.0468532655695554	390	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO DNA DAMAGE|PROTEOLYSIS	NUCLEUS		Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses; relative distribution to the nucleus increases upon DNA replication stress	positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance|regulation of DNA repair|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter in response to stress|positive regulation of transcription from RNA polymerase II promoter in response to stress|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YKR104W	YKR104W	YKR104W	hom	Verified	3.57933959771298	0.000172231800295803	yes	32	0.00017358869761768	25	NA	FT	NUCLEOTIDE METABOLISM			Putative transporter of the multidrug resistance-associated protein (MRP) subfamily; contains a stop codon in S288C; adjacent ORFs YKR103W and YKR104W are merged in different strain backgrounds	transport	ATPase activity, coupled to transmembrane movement of substances	integral to membrane|membrane
YDR442W_d	YDR442W	YDR442W	hom	Dubious	3.57233341241804	0.000176907275798848	yes	33	0.000832671093902207	27	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDR304C	YDR304C	CPR5	hom	Verified	3.5712982844185	0.000177608034363657	yes	34	9.53726524568541e-05	21	NA	FT		ENDOPLASMIC RETICULUM		Peptidyl-prolyl cis-trans isomerase (cyclophilin) of the endoplasmic reticulum, catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; transcriptionally induced in response to unfolded proteins in the ER	biological_process	peptidyl-prolyl cis-trans isomerase activity	endoplasmic reticulum|cytoplasm
YJR077C	YJR077C	MIR1	hom	Verified	3.55107902986286	0.000191827598143168	yes	35	0.000170092901058292	18	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; functionally redundant with Pic2p but more abundant than Pic2p under normal conditions; phosphorylated	phosphate ion transmembrane transport	inorganic phosphate transmembrane transporter activity	mitochondrion|integral to membrane|integral to mitochondrial inner membrane
YGR243W	YGR243W	FMP43	hom	Verified	3.52470372423417	0.000211978338135488	yes	36	0.000208323476759945	24	NA	FT		MITOCHONDRION		Highly conserved subunit of the mitochondrial pyruvate carrier; a mitochondrial inner membrane complex comprised of Fmp37p/Mpc1p and either Mpc2p or Fmp43p/Mpc3p mediates mitochondrial pyruvate uptake; more highly expressed in glucose-containing minimal medium than in lactate-containing medium; expression regulated by osmotic and alkaline stresses; protein abundance increases in response to DNA replication stress	mitochondrial pyruvate transport	pyruvate transmembrane transporter activity	mitochondrion|mitochondrial membrane
YGR049W	YGR049W	SCM4	hom	Verified	3.4943119812333	0.000237642627120832	yes	37	0.000342491738437313	9	NA	FT		MITOCHONDRION		Mitochondrial outer membrane protein of unknown function; predicted to have 4 transmembrane segments; import is mediated by Tom70p and Mim1p; interacts genetically with a cdc4 mutation	biological_process	molecular_function	mitochondrial outer membrane|mitochondrion|integral to membrane
YNL246W	YNL246W	VPS75	hom	Verified	3.48786851610032	0.000243443723885041	yes	38	0.000652333076831241	57	NA	FT	PROTEIN LOCALIZATION|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		NAP family histone chaperone; binds to histones and Rtt109p, stimulating histone acetyltransferase activity; possesses nucleosome assembly activity in vitro; proposed role in vacuolar protein sorting and in double-strand break repair; protein abundance increases in response to DNA replication stress	double-strand break repair via nonhomologous end joining|nucleosome assembly|positive regulation of histone acetylation	histone binding|acetyltransferase activator activity	chromatin|nucleus
YOR247W	YOR247W	SRL1	hom	Verified	3.48551277762204	0.000245597381793708	yes	39	0.000341701830906703	24	NA	FT	CELL WALL ORG/BIOGENESIS	SITE OF POLARIZED GROWTH		Mannoprotein that exhibits a tight association with the cell wall; required for cell wall stability in the absence of GPI-anchored mannoproteins; has a high serine-threonine content; expression is induced in cell wall mutants; SRL1 has a paralog, SVS1, that arose from the whole genome duplication	fungal-type cell wall organization|nucleobase-containing compound metabolic process	molecular_function	fungal-type cell wall|fungal-type vacuole|cytoplasm|cellular bud tip
YBL031W	YBL031W	SHE1	hom	Verified	3.48453117347344	0.000246500014956368	yes	40	0.000117768101048491	50	NA	FT	CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION	NUCLEUS|SITE OF POLARIZED GROWTH|CYTOSKELETON		Mitotic spindle protein; interacts with components of the Dam1 (DASH) complex, its effector Sli15p, and microtubule-associated protein Bim1p; also localizes to nuclear microtubules and to the bud neck in a ring-shaped structure; inhibits dynein function	mitotic spindle elongation	molecular_function	microtubule cytoskeleton|nuclear microtubule|cellular bud neck|astral microtubule|spindle
YDR363W-A	YDR363W-A	SEM1	hom	Verified	3.42350359696772	0.00030909716825183	yes	41	0.000308504847959656	24	NA	FT	VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|PROTEOLYSIS|RNA LOCALIZATION	NUCLEUS		Component of lid subcomplex of the 26S proteasome regulatory subunit; involved in mRNA export mediated by the TREX-2 complex (Sac3p-Thp1p); ortholog of human DSS1; protein abundance increases in response to DNA replication stress	proteasome assembly|proteasomal ubiquitin-dependent protein catabolic process|regulation of cell cycle|mRNA export from nucleus|exocytosis|filamentous growth|ubiquitin-dependent protein catabolic process	molecular_function	cytosol|nucleus|proteasome storage granule|proteasome regulatory particle, lid subcomplex
YEL028W_d	YEL028W	YEL028W	hom	Dubious	3.41286631071215	0.000321417345280823	yes	42	0.000985517855885947	31	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YJR033C	YJR033C	RAV1	hom	Verified	3.40003569314233	0.000336885286571365	yes	43	0.00142974328492143	104	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|ION HOMEOSTASIS	ENDOMEMBRANE SYSTEM		Subunit of the RAVE complex (Rav1p, Rav2p, Skp1p), which promotes assembly of the V-ATPase holoenzyme; required for transport between the early and late endosome/PVC and for localization of TGN membrane proteins; potential Cdc28p substrate	early endosome to late endosome transport|vacuolar acidification|regulation of protein complex assembly	molecular_function	RAVE complex|cytoplasm|extrinsic to membrane
YMR264W	YMR264W	CUE1	hom	Verified	3.26798041843602	0.000541589297594753	yes	44	0.00132323851587832	87	NA	FF|FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|PROTEOLYSIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION	UBIQUITIN LIGASE COMPLEX	Ubiquitin-binding protein; endoplasmic reticulum membrane protein that recruits the ubiquitin-conjugating enzyme Ubc7p to the ER where it functions in protein degradation; contains a CUE domain that binds ubiquitin to facilitate intramolecular monoubiquitination; CUE1 has a paralog, CUE4, that arose from the whole genome duplication	ER-associated protein catabolic process|establishment of protein localization to endoplasmic reticulum membrane	ubiquitin-protein ligase activator activity	Doa10p ubiquitin ligase complex|mitochondrion|integral to endoplasmic reticulum membrane
YNL123W	YNL123W	NMA111	hom	Verified	3.26127546314319	0.000554561176970503	yes	45	0.00134067408792878	63	NA	FT	LIPID METABOLISM|PROTEOLYSIS	NUCLEUS		Serine protease and general molecular chaperone; involved in response to heat stress and promotion of apoptosis; may contribute to lipid homeostasis; sequence similarity to the mammalian Omi/HtrA2 family of serine proteases	apoptotic process|cellular lipid metabolic process|protein catabolic process|cellular response to heat	serine-type peptidase activity	nucleus
YPR060C	YPR060C	ARO7	hom	Verified	3.25493665750707	0.000567088294018578	yes	46	0.00316115712506361	114	NA	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Chorismate mutase, catalyzes the conversion of chorismate to prephenate to initiate the tyrosine/phenylalanine-specific branch of aromatic amino acid biosynthesis	aromatic amino acid family biosynthetic process	chorismate mutase activity	nucleus|cytoplasm
YPL272C_p	YPL272C	YPL272C	hom	Uncharacterized	3.25243146119748	0.000572110937435395	yes	47	0.00136990533433371	36	NA					Putative protein of unknown function; gene expression induced in response to ketoconazole; YPL272C is not an essential gene	biological_process	molecular_function	cellular_component
YDR493W	YDR493W	MZM1	hom	Verified	3.24388980132346	0.000589546769267481	yes	48	0.000549902280818703	48	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Protein required for assembly of the cytochrome bc(1) complex; acts as a chaperone for Rip1p and facilitates its insertion into the complex at a late stage of assembly; localized to the mitochondrial matrix; null mutant exhibits a respiratory growth defect and reduced mitochondrial zinc levels, which is characteristic of mutations affecting bc(1) complex assembly; human LYRM7 is a functional ortholog	mitochondrial respiratory chain complex III assembly	molecular_function	mitochondrion|mitochondrial matrix
YBR076W	YBR076W	ECM8	hom	Verified	3.21887777667097	0.000643466633187459	yes	49	0.000746585017476872	24	NA	FT	CELL WALL ORG/BIOGENESIS			Non-essential protein of unknown function	fungal-type cell wall organization	molecular_function	cellular_component
YPL174C	YPL174C	NIP100	hom	Verified	3.2082163622177	0.000667804894021896	yes	50	0.00141805947174885	61	NA	FT	CELL CYCLE|CYTOSKELETON ORGANIZATION	CYTOSKELETON		Large subunit of the dynactin complex, which is involved in partitioning the mitotic spindle between mother and daughter cells; putative ortholog of mammalian p150(glued)	establishment of mitotic spindle orientation	microtubule binding	dynactin complex|cell cortex|spindle pole body|astral microtubule
YPR074C	YPR074C	TKL1	hom	Verified	3.18349173627558	0.000727551333675642	yes	51	0.00298717834603238	105	NA	FF|FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS			Transketolase; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids; TKL1 has a paralog, TKL2, that arose from the whole genome duplication	pentose-phosphate shunt	transketolase activity	cytoplasm
YKL146W	YKL146W	AVT3	hom	Verified	3.15166319139073	0.00081171708114339	yes	52	0.000898900916124334	25	NA	FT	VACUOLAR TRANSPORT			Vacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters	amino acid export from vacuole	transporter activity|L-glutamine transmembrane transporter activity|L-isoleucine transmembrane transporter activity|L-tyrosine transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane
YBL029W_p	YBL029W	YBL029W	hom	Uncharacterized	3.14709030054993	0.000824520127593871	yes	53	0.00133465250806532	27	NA	FT		NUCLEUS		Non-essential protein of unknown function	biological_process	molecular_function	nucleus|cytoplasm
YDR514C	YDR514C	YDR514C	hom	Verified	3.11521682823739	0.00091904869872734	yes	54	0.000683131214296137	38	NA	FT		NUCLEUS|MITOCHONDRION		Protein of unknown function that localizes to mitochondria; overexpression affects endocytic protein trafficking; YDR514C has a paralog, GFD2, that arose from the whole genome duplication	biological_process	molecular_function	mitochondrion|nucleus
YKL176C	YKL176C	LST4	hom	Verified	3.09761155582889	0.000975434778086517	yes	55	0.00227008759215597	51	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM		Protein possibly involved in a post-Golgi secretory pathway; required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface	intracellular protein transport|vesicle-mediated transport|protein transport|Golgi to plasma membrane transport	protein transporter activity	vesicle coat
YLR395C	YLR395C	COX8	hom	Verified	3.07221426246529	0.00106238574845404	no	56	0.00235689791798662	30	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Subunit VIII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain	mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity	mitochondrion|integral to membrane|mitochondrial respiratory chain complex IV
YNL094W	YNL094W	APP1	hom	Verified	2.95555217222816	0.00156054952480517	no	57	0.00191900879027551	55	NA	FT	CYTOSKELETON ORGANIZATION	CYTOSKELETON		Phosphatidate phosphatase, converts phosphatidate to diacylglycerol; App1p, Pah1p, Dpp1p, and Lpp1p are responsible for all the phosphatidate phosphatase activity; component of cortical actin patches; interacts with components of endocytic pathway	actin cytoskeleton organization	molecular_function	actin cytoskeleton|actin cortical patch
YLR455W	YLR455W	YLR455W	hom	Verified	2.93280324126461	0.00167958351147377	no	58	0.00293264012042627	57	NA	FT		NUCLEUS		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO); protein abundance increases in response to DNA replication stress	biological_process	molecular_function	nucleus
YER131W	YER131W	RPS26B	hom	Verified	2.93155966507811	0.00168632286799249	no	59	0.00196691863195055	39	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S26, no bacterial homolog; RPS26B has a paralog, RPS26A, that arose from the whole genome duplication	cytoplasmic translation|rRNA export from nucleus	structural constituent of ribosome	cytosolic small ribosomal subunit
YGR247W	YGR247W	CPD1	hom	Verified	2.92067320073601	0.00174637995817011	no	60	0.00120225451746147	41	NA	FT	NUCLEOTIDE METABOLISM	GOLGI APPARATUS		Cyclic nucleotide phosphodiesterase; hydrolyzes ADP-ribose 1'', 2''-cyclic phosphate to ADP-ribose 1''-phosphate; may have a role in tRNA splicing; no detectable phenotype is conferred by null mutation or by overexpression; protein abundance increases in response to DNA replication stress	cyclic nucleotide metabolic process	2',3'-cyclic-nucleotide 3'-phosphodiesterase activity	clathrin-coated vesicle
YGL107C	YGL107C	RMD9	hom	Verified	2.90997910204095	0.00180726461854639	no	61	0.00281706781264743	48	NA	FT	TRANSLATION|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Mitochondrial protein required for respiratory growth; mutant phenotype and genetic interactions suggest a role in delivering mt mRNAs to ribosomes; located on matrix face of the inner membrane and loosely associated with mitoribosomes	translational initiation|regulation of mRNA stability|aerobic respiration	molecular_function	extrinsic to mitochondrial inner membrane|mitochondrion
YDR479C	YDR479C	PEX29	hom	Verified	2.88684132572984	0.00194565209587309	no	62	0.0022487764833599	76	NA	FT	PEROXISOME ORGANIZATION			Peroxisomal integral membrane peroxin; involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p; forms ER foci upon DNA replication stress	peroxisome organization	molecular_function	integral to membrane|peroxisomal membrane
YPL257W_p	YPL257W	YPL257W	hom	Uncharacterized	2.88377957564349	0.00196466842588993	no	63	0.00345848104382623	61	NA	FT	CELL CYCLE			Putative protein of unknown function; homozygous diploid deletion strain exhibits low budding index; physically interacts with Hsp82p; YPL257W is not an essential gene	biological_process	molecular_function	integral to membrane
YOL024W_p	YOL024W	YOL024W	hom	Uncharacterized	2.87278243771403	0.00203437103330644	no	64	0.00120761953562737	27	NA					Putative protein of unknown function; predicted to have thiol-disulfide oxidoreductase active site; YOL024W has a paralog, IGD1, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YDL012C	YDL012C	YDL012C	hom	Verified	2.86642356503344	0.00207569197160313	no	65	0.000459765868936517	21	NA	FT		PLASMA MEMBRANE		Tail-anchored plasma membrane protein with a conserved CYSTM module; possibly involved in response to stress; may contribute to non-homologous end-joining (NHEJ) based on ydl012c htz1 double null phenotype; YDL012C has a paralog, YBR016W, that arose from the whole genome duplication	biological_process	molecular_function	plasma membrane
YCR036W	YCR036W	RBK1	hom	Verified	2.84936370973133	0.00219033849670604	no	66	0.0100400521742304	101	NA	FT	CARBOHYDRATE METABOLISM	NUCLEUS		Putative ribokinase	D-ribose metabolic process	ribokinase activity|ATP binding	nucleus|cytoplasm
YNR020C	YNR020C	ATP23	hom	Verified	2.83288057176261	0.00230653087022807	no	67	0.00464457241338582	39	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Putative metalloprotease of the mitochondrial inner membrane, required for processing of Atp6p; has an additional role in assembly of the F0 sector of the F1F0 ATP synthase complex; substrate of the Mia40p-Erv1p disulfide relay system, and folding is assisted by Mia40p	protein processing|mitochondrial proton-transporting ATP synthase complex assembly	metalloendopeptidase activity	mitochondrial inner membrane|mitochondrial intermembrane space
YLR200W	YLR200W	YKE2	hom	Verified	2.83163681316107	0.00231552084887371	no	68	0.00776041191431675	119	NA	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS	NUCLEUS		Subunit of the heterohexameric Gim/prefoldin protein complex involved in the folding of alpha-tubulin, beta-tubulin, and actin	protein folding|tubulin complex assembly	tubulin binding	prefoldin complex|cytoplasm
YGL057C	YGL057C	GEP7	hom	Verified	2.83065341730938	0.00232265135455064	no	69	0.00318545402604443	34	NA	FT		MITOCHONDRION		Protein of unknown function; null mutant exhibits a respiratory growth defect and synthetic interactions with prohibitin (phb1) and gem1; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YMR055C	YMR055C	BUB2	hom	Verified	2.805948436485	0.00250843598707244	no	70	0.00148119514437585	50	NA	FT	CELL CYCLE|SIGNALING|CELL DIVISION|NUCLEOTIDE METABOLISM	CYTOSKELETON		Mitotic exit network regulator, forms GTPase-activating Bfa1p-Bub2p complex that binds Tem1p and spindle pole bodies, blocks cell cycle progression before anaphase in response to spindle and kinetochore damage	regulation of exit from mitosis|mitotic cell cycle spindle orientation checkpoint	GTPase activator activity	spindle pole body
YPL107W_p	YPL107W	YPL107W	hom	Uncharacterized	2.7996232686022	0.00255811390282736	no	71	0.00270291187679235	42	NA	FT		MITOCHONDRION		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YPL107W is not an essential gene	biological_process	molecular_function	mitochondrion
YLR433C	YLR433C	CNA1	hom	Verified	2.78584426450458	0.00266942573700909	no	72	0.000993886488805943	36	NA	FT	SIGNALING|ION HOMEOSTASIS|CELL WALL ORG/BIOGENESIS|ION HOMEOSTASIS			Calcineurin A; one isoform (the other is CMP2) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1	adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion|fungal-type cell wall organization|cellular ion homeostasis	calcium-dependent protein serine/threonine phosphatase activity	calcineurin complex|cytoplasm
YML068W	YML068W	ITT1	hom	Verified	2.78023146344189	0.00271600826881384	no	73	0.000957363621626865	29	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION			Protein that modulates the efficiency of translation termination, interacts with translation release factors eRF1 (Sup45p) and eRF3 (Sup35p) in vitro, contains a zinc finger domain characteristic of the TRIAD class of proteins	regulation of translational termination	molecular_function	cellular_component
YMR022W	YMR022W	UBC7	hom	Verified	2.77750446173027	0.00273890440070945	no	74	0.00519565627887825	93	NA	FT	CHROMATIN ORGANIZATION|CELL WALL ORG/BIOGENESIS|PROTEOLYSIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly	fungal-type cell wall organization|chromatin assembly or disassembly|ER-associated protein catabolic process	ubiquitin-protein ligase activity	endoplasmic reticulum membrane
YGR050C_p	YGR050C	YGR050C	hom	Uncharacterized	2.74833694316842	0.00299492097414677	no	75	0.00223238504640114	42	NA					Protein of unknown function; mRNA identified as translated by ribosome profiling data	biological_process	molecular_function	cellular_component
YCR049C_d	YCR049C	YCR049C	hom	Dubious	2.74571947057243	0.00301891838213384	no	76	0.00596963675616734	63	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YLR296W_d	YLR296W	YLR296W	hom	Dubious	2.74503306321913	0.0030252400775402	no	77	0.00276382754067318	43	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YLR363C	YLR363C	NMD4	hom	Verified	2.74437707374408	0.00303129277099524	no	78	0.00285934726929	49	NA					Protein that may be involved in nonsense-mediated mRNA decay; interacts with Nam7p, relocalizes from nucleus to cytoplasmic foci upon DNA replication stress	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	molecular_function	cytoplasm
YPR146C_d	YPR146C	YPR146C	hom	Dubious	2.73600703699846	0.00310948480452107	no	79	0.00213380451038351	79	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDR179C	YDR179C	CSN9	hom	Verified	2.70304978220121	0.00343532276338213	no	80	0.00282391198813619	24	NA	FT	SIGNALING	NUCLEUS		Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling	adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion|cullin deneddylation	molecular_function	signalosome
YIL029C_p	YIL029C	YIL029C	hom	Uncharacterized	2.69708304706413	0.00349749115236398	no	81	0.00606482022611533	102	NA					Putative protein of unknown function; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO); YIL029C has paralog YPR071W	biological_process	molecular_function	integral to membrane
YOL039W	YOL039W	RPP2A	hom	Verified	2.69602314627255	0.0035086395195743	no	82	0.00730384046088916	101	NA	FT	TRANSLATION		RIBOSOME	Ribosomal protein P2 alpha, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm	translational elongation|cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YGR241C	YGR241C	YAP1802	hom	Verified	2.69323257106588	0.00353814443490323	no	83	0.00519442902040189	81	NA	FT	VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON		Protein of the AP180 family, involved in clathrin cage assembly; binds Pan1p and clathrin; YAP1802 has a paralog, YAP1801, that arose from the whole genome duplication	endocytosis	clathrin binding	actin cortical patch
YDR065W	YDR065W	RRG1	hom	Verified	2.67405209222448	0.00374704048555084	no	84	0.00377703048356535	81	NA	FT	ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS	MITOCHONDRION		Protein of unknown function, required for vacuolar acidification and mitochondrial genome maintenance; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	mitochondrial genome maintenance|vacuolar acidification	molecular_function	mitochondrion
YOR265W	YOR265W	RBL2	hom	Verified	2.67113864683236	0.00377972077993609	no	85	0.00608408630670373	74	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION	CYTOSKELETON		Protein involved in microtubule morphogenesis; required for protection from excess free beta-tubulin; proposed to be involved the folding of beta-tubulin; similar to mouse beta-tubulin cofactor A; protein abundance increases in response to DNA replication stress	tubulin complex assembly|tubulin complex biogenesis	tubulin binding|beta-tubulin binding	cytoplasm
YLL062C	YLL062C	MHT1	hom	Verified	2.64011679534317	0.00414387299594374	no	86	0.00329860608165484	22	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			S-methylmethionine-homocysteine methyltransferase, functions along with Sam4p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio	sulfur amino acid metabolic process	homocysteine S-methyltransferase activity	cytoplasm
YPL264C_p	YPL264C	YPL264C	hom	Uncharacterized	2.63826739252457	0.00416654232635597	no	87	0.00253091724112496	30	NA					Putative membrane protein of unknown function; physically interacts with Hsp82p; YPL264C is not an essential gene	biological_process	molecular_function	integral to membrane
YML009C-A_d	YML009C-A	YML009C-A	hom	Dubious	2.63160778846866	0.00424909525992411	no	88	0.00885203660069829	98	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDR462W	YDR462W	MRPL28	hom	Verified	2.62478984987649	0.00433512308900756	no	89	0.00549631741018867	88	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YBR056W-A_p	YBR056W-A	YBR056W-A	hom	Uncharacterized	2.60533493221588	0.00458922439731494	no	90	0.00870832799613005	94	NA					Protein of unknown function; mRNA identified as translated by ribosome profiling data; partially overlaps the dubious ORF YBR056C-B	biological_process	molecular_function	cellular_component
YMR086C-A_d	YMR086C-A	YMR086C-A	hom	Dubious	2.58954610368809	0.00480512765960262	no	91	0.00400128455197405	79	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YER096W	YER096W	SHC1	hom	Verified	2.58674482693359	0.00484436565042806	no	92	0.00559304948392417	83	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM			Sporulation-specific activator of Chs3p (chitin synthase III); required for the synthesis of the chitosan layer of ascospores; transcriptionally induced at alkaline pH; SHC1 has a paralog, SKT5, that arose from the whole genome duplication	ascospore formation|chitin biosynthetic process	enzyme activator activity	prospore membrane
YLR434C_d	YLR434C	YLR434C	hom	Dubious	2.57922144788438	0.00495116422253051	no	93	0.00782601293814478	67	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF TSR2/YLR435W	Unknown	Unknown	Unknown
YBR187W_p	YBR187W	GDT1	hom	Uncharacterized	2.56186118883862	0.00520564605752773	no	94	0.0062549679229319	105	NA					Putative protein of unknown function; expression is reduced in a gcr1 null mutant; GFP-fusion protein localizes to the vacuole; expression pattern and physical interactions suggest a possible role in ribosome biogenesis	biological_process	molecular_function	integral to membrane|fungal-type vacuole
YKR093W	YKR093W	PTR2	hom	Verified	2.56058682179479	0.00522477748764381	no	95	0.0128597671121487	179	NA	FF|FT	PROTEIN LOCALIZATION	PLASMA MEMBRANE		Integral membrane peptide transporter, mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p	dipeptide transport|tripeptide transport|peptide transport	dipeptide transporter activity|tripeptide transporter activity|peptide transporter activity	integral to membrane|plasma membrane
YNL051W	YNL051W	COG5	hom	Verified	2.55104073196502	0.00537008864396889	no	96	0.0405814449540628	214	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments	intra-Golgi vesicle-mediated transport|CVT pathway	molecular_function	Golgi transport complex
YMR251W	YMR251W	GTO3	hom	Verified	2.54686232559644	0.00543481533935704	no	97	0.00693401364669168	52	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Omega class glutathione transferase; putative cytosolic localization	glutathione metabolic process	glutathione transferase activity	cytoplasm
YPL171C	YPL171C	OYE3	hom	Verified	2.54474861398991	0.00546782170623335	no	98	0.00631620773788898	74	NA	FT	OXIDATION-REDUCTION PROCESS			Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN), homologous to Oye2p with different ligand binding and catalytic properties; has potential roles in oxidative stress response and programmed cell death	apoptotic process	NADPH dehydrogenase activity	cellular_component
YBL032W	YBL032W	HEK2	hom	Verified	2.53650108385993	0.00559831980680673	no	99	0.00428275706465193	79	NA	FT	CHROMATIN ORGANIZATION|TRANSLATION|RNA LOCALIZATION	NUCLEUS|CHROMOSOME		RNA binding protein involved in the asymmetric localization of ASH1 mRNA; represses translation of ASH1 mRNA, an effect reversed by Yck1p-dependent phosphoryation; regulates telomere position effect and length; similarity to hnRNP-K	telomere maintenance via telomerase|intracellular mRNA localization|mRNA stabilization	mRNA binding	nuclear chromosome, telomeric region|cytoplasmic mRNA processing body|cytoplasm
YLR131C	YLR131C	ACE2	hom	Verified	2.5336407538889	0.0056442197237006	no	100	0.028524268984719	306	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CELL DIVISION	NUCLEUS		Transcription factor required for septum destruction after cytokinesis; phosphorylation by Cbk1p blocks nuclear exit during M/G1 transition, causing localization to daughter cell nuclei, and also increases Ace2p activity; phosphorylation by Cdc28p and Pho85p prevents nuclear import during cell cycle phases other than cytokinesis; part of RAM network that regulates cellular polarity and morphogenesis; ACE2 has a paralog, SWI5, that arose from the whole genome duplication	Unknown|regulation of transcription involved in G1 phase of mitotic cell cycle	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity|core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding	cytosol|nucleus
YJR130C	YJR130C	STR2	hom	Verified	2.53087963699827	0.00568884421696968	no	101	0.00417296582155535	39	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Cystathionine gamma-synthase, converts cysteine into cystathionine	sulfur compound metabolic process|transsulfuration	cystathionine gamma-synthase activity	nucleus|cytoplasm
YKL093W	YKL093W	MBR1	hom	Verified	2.53025491140578	0.0056989842239987	no	102	0.00446083008874687	64	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Protein involved in mitochondrial functions and stress response; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants	aerobic respiration	molecular_function	cellular_component
YOL114C_p	YOL114C	YOL114C	hom	Uncharacterized	2.52646583741643	0.00576082967452089	no	103	0.00601604272576684	79	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION			Putative protein of unknown function with similarity to human ICT1 and prokaryotic factors that may function in translation termination; YOL114C is not an essential gene	biological_process	molecular_function	cellular_component
YNL177C	YNL177C	MRPL22	hom	Verified	2.52116543213871	0.00584834234929192	no	104	0.016772825085833	122	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YPL060W	YPL060W	MFM1	hom	Verified	2.50836705240096	0.00606453005425812	no	105	0.0145458924544743	99	NA	FT	RNA PROCESSING|ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Mitochondrial inner membrane magnesium transporter, involved in maintenance of mitochondrial magnesium concentrations and membrane potential; indirectly affects splicing of group II introns; functionally and structurally related to Mrs2p	mitochondrial magnesium ion transport	magnesium ion transmembrane transporter activity	integral to membrane|mitochondrial inner membrane
YDL024C	YDL024C	DIA3	hom	Verified	2.48471658314777	0.00648273061397163	no	106	0.0129930453193948	88	NA					Protein of unknown function, involved in invasive and pseudohyphal growth	pseudohyphal growth|invasive growth in response to glucose limitation	acid phosphatase activity	fungal-type cell wall
YHR184W	YHR184W	SSP1	hom	Verified	2.47300603838612	0.00669909395768277	no	107	0.00633658280826459	88	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL WALL ORG/BIOGENESIS|CELL DIVISION			Protein involved in the control of meiotic nuclear division and coordination of meiosis with spore formation; transcription is induced midway through meiosis	ascospore wall assembly|protein complex assembly	molecular_function	prospore membrane
YGR290W_d	YGR290W	YGR290W	hom	Dubious	2.47072308945616	0.00674200926781886	no	108	0.00789988151633109	109	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; putative HLH protein; partially overlaps the verified ORF MAL11/YGR289C (a high-affinity maltose transporter)	Unknown	Unknown	Unknown
YCR069W	YCR069W	CPR4	hom	Verified	2.4656225665298	0.00683876859960706	no	109	0.00575315965945957	64	NA					Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; has a potential role in the secretory pathway	biological_process	peptidyl-prolyl cis-trans isomerase activity	membrane
YIL140W	YIL140W	AXL2	hom	Verified	2.45930274388657	0.00696035865118378	no	110	0.00668901467480616	72	NA	FT	CELL CYCLE|CELL DIVISION	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON		Integral plasma membrane protein required for axial budding in haploid cells, localizes to the incipient bud site and bud neck; glycosylated by Pmt4p; potential Cdc28p substrate	axial cellular bud site selection|cellular bud site selection	molecular_function	integral to plasma membrane|cellular bud neck|septin ring
YKL137W	YKL137W	CMC1	hom	Verified	2.45663491354828	0.00701225655467018	no	111	0.00630987512977479	72	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Evolutionarily conserved copper-binding protein of the mitochondrial intermembrane space, may be involved in delivering copper from the matrix to the cytochrome c oxidase complex; contains a twin CX9C motif	mitochondrial respiratory chain complex IV assembly	copper ion binding	extrinsic to mitochondrial inner membrane|mitochondrial intermembrane space
YHR130C_d	YHR130C	YHR130C	hom	Dubious	2.45037904669123	0.00713529494227127	no	112	0.00847453045455329	57	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YCR017C	YCR017C	CWH43	hom	Verified	2.41804127762369	0.00780215328578019	no	113	0.0147296881234712	131	NA	FT	LIPID METABOLISM|CELL WALL ORG/BIOGENESIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Putative sensor/transporter protein involved in cell wall biogenesis; contains 14-16 transmembrane segments and several putative glycosylation and phosphorylation sites; null mutation is synthetically lethal with pkc1 deletion	fungal-type cell wall organization|GPI anchor biosynthetic process	molecular_function	integral to membrane|integral to plasma membrane|cellular bud neck|cellular bud tip
YDR093W	YDR093W	DNF2	hom	Verified	2.41751499315514	0.00781344509763018	no	114	0.00506308467390213	52	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase	intracellular protein transport|phospholipid translocation|endocytosis|establishment or maintenance of cell polarity	phospholipid-translocating ATPase activity	integral to membrane|plasma membrane
YMR038C	YMR038C	CCS1	hom	Verified	2.41570215430199	0.00785245099904294	no	115	0.0339319525886514	262	NA	FF|FT	ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|RESPONSE TO OXIDATIVE STRESS	NUCLEUS|MITOCHONDRION		Copper chaperone for superoxide dismutase Sod1p; involved in oxidative stress protection; Met-X-Cys-X2-Cys motif within the N-terminal portion is involved in insertion of copper into Sod1p under conditions of copper deprivation; protein abundance increases in response to DNA replication stress	intracellular copper ion transport	superoxide dismutase copper chaperone activity	cytosol|mitochondrial inner membrane|nucleus
YNL285W_d	YNL285W	YNL285W	hom	Dubious	2.41476621707118	0.0078726560368656	no	116	0.00726564916832189	54	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YOR032C	YOR032C	HMS1	hom	Verified	2.41454591373471	0.00787741859486303	no	117	0.0111856663800856	84	NA	FT		NUCLEUS		Basic helix-loop-helix (bHLH) protein with similarity to myc-family transcription factors; overexpression confers hyperfilamentous growth and suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant	pseudohyphal growth	sequence-specific DNA binding transcription factor activity	cellular_component
YKR049C	YKR049C	FMP46	hom	Verified	2.40864716019016	0.00800588479864151	no	118	0.0062182183871665	78	NA	FT	OXIDATION-REDUCTION PROCESS	MITOCHONDRION		Putative redox protein containing a thioredoxin fold; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	oxidoreductase activity	mitochondrion
YBR242W_p	YBR242W	YBR242W	hom	Uncharacterized	2.4068664358833	0.00804502660749548	no	119	0.0181753718257949	110	NA	FT		NUCLEUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YBR242W is not an essential gene	biological_process	molecular_function	nucleus|cytoplasm
YOR192C	YOR192C	THI72	hom	Verified	2.38693780517361	0.00849468258872841	no	120	0.00964193490113504	115	NA					Transporter of thiamine or related compound; shares sequence similarity with Thi7p	thiamine transport	transporter activity	integral to membrane|membrane
YOL129W	YOL129W	VPS68	hom	Verified	2.38267272025384	0.00859373353430911	no	121	0.0117317819051451	134	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	MITOCHONDRION		Vacuolar membrane protein of unknown function involved in vacuolar protein sorting; also detected in the mitochondria	late endosome to vacuole transport via multivesicular body sorting pathway|protein targeting to vacuole	molecular_function	Vps55/Vps68 complex|mitochondrion|fungal-type vacuole membrane|integral to membrane
YER121W_p	YER121W	YER121W	hom	Uncharacterized	2.37715276710199	0.00872343037164461	no	122	0.0128493799163339	81	NA					Putative protein of unknown function; may be involved in phosphatase regulation and/or generation of precursor metabolites and energy	biological_process	molecular_function	cellular_component
YDR314C	YDR314C	RAD34	hom	Verified	2.36491908758308	0.00901700522594152	no	123	0.00642853762148196	47	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		Protein involved in nucleotide excision repair (NER); homologous to RAD4	nucleotide-excision repair	molecular_function	nucleus
YDR206W	YDR206W	EBS1	hom	Verified	2.35205818258993	0.00933492719011543	no	124	0.0105319090848337	38	NA	FT	TRANSLATION	NUCLEUS|CHROMOSOME		Protein involved in inhibition of translation and nonsense-mediated decay; interacts with cap binding protein Cdc33p and with Nam7p; localizes to P-bodies upon glucose starvation; mRNA abundance regulated by mRNA decay factors	negative regulation of translation|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	molecular_function	cytoplasmic mRNA processing body|cytoplasm
YLR300W	YLR300W	EXG1	hom	Verified	2.34941775355121	0.00940139880295291	no	125	0.0059015872336369	74	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM			Major exo-1,3-beta-glucanase of the cell wall, involved in cell wall beta-glucan assembly; exists as three differentially glycosylated isoenzymes	fungal-type cell wall organization|cellular glucan metabolic process	glucan exo-1,3-beta-glucosidase activity	extracellular region|fungal-type cell wall
YLR303W	YLR303W	MET17	hom	Verified	2.34445848815507	0.00952736577148984	no	126	0.0128963234583485	138	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Methionine and cysteine synthase (O-acetyl homoserine-O-acetyl serine sulfhydrylase), required for sulfur amino acid synthesis	methionine metabolic process|cysteine biosynthetic process	O-acetylhomoserine aminocarboxypropyltransferase activity|cysteine synthase activity	plasma membrane|cytoplasm
YLR280C_d	YLR280C	YLR280C	hom	Dubious	2.33986259640102	0.00964541780606165	no	127	0.00600293249697531	59	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YNL027W	YNL027W	CRZ1	hom	Verified	2.33572863559485	0.00975269453360636	no	128	0.00736391651517136	50	NA	FT	TRANSCRIPTION FROM RNA POL II|SIGNALING|ION HOMEOSTASIS|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|ION HOMEOSTASIS	NUCLEUS		Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress	regulation of potassium ion concentration by positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter in response to calcium ion|positive regulation of sodium ion transport by positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter in response to increased salt|cell wall chitin biosynthetic process|positive regulation of transcription from RNA polymerase II promoter in response to alkalinity|positive regulation of transcription from RNA polymerase II promoter by pheromones|ion homeostasis|Unknown|positive regulation of transcription from RNA polymerase II promoter	core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus|cytoplasm
YLR073C	YLR073C	RFU1	hom	Verified	2.33181093871722	0.00985531966309768	no	129	0.0149565200645115	120	NA					Protein that inhibits Doa4p deubiquitinating activity; contributes to ubiquitin homeostasis by regulating the conversion of free ubiquitin chains to ubiquitin monomers by Doa4p; GFP-fusion protein localizes to endosomes	regulation of ubiquitin homeostasis	enzyme inhibitor activity	endosome
YJR049C	YJR049C	UTR1	hom	Verified	2.33171996986697	0.00985771377786232	no	130	0.01777225413281	212	NA	FF|FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS|COFACTOR METABOLISM	NUCLEUS		ATP-NADH kinase; phosphorylates both NAD and NADH; active as a hexamer; enhances the activity of ferric reductase (Fre1p); UTR1 has a paralog, YEF1, that arose from the whole genome duplication	cellular iron ion homeostasis|NADP biosynthetic process	NAD+ kinase activity|NADH kinase activity	nucleus|cytoplasm
YDL002C	YDL002C	NHP10	hom	Verified	2.32327896979062	0.0100820854129982	no	131	0.0140016931831294	143	NA	FT	CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Protein related to mammalian high mobility group proteins; preferentially binds DNA ends, protecting them from exonucleatic cleavage; likely component of the chromatin-remodeling complex INO80 complex; proposed to be involved in DNA repair	double-strand break repair|nucleosome mobilization	DNA end binding|loop DNA binding	nucleus|Ino80 complex
YDR008C_d	YDR008C	YDR008C	hom	Dubious	2.32164897003215	0.0101259223885996	no	132	0.123173268142836	630	NA	FF				Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YNR061C	YNR061C	YNR061C	hom	Verified	2.31988732756042	0.0101734866424281	no	133	0.00742380860003905	97	NA					Protein of unknown function; relocalizes from vacuole to cytoplasm upon DNA replication stress	biological_process	molecular_function	integral to membrane|fungal-type vacuole
YNL214W	YNL214W	PEX17	hom	Verified	2.31413775138441	0.0103300835995599	no	134	0.0135070124995802	106	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|PEROXISOME ORGANIZATION			Peroxisomal membrane peroxin and subunit of the docking complex that facilitates the import of peroxisomal matrix proteins; required for peroxisome biogenesis	protein import into peroxisome matrix, docking	protein binding	peroxisomal membrane
YKR020W	YKR020W	VPS51	hom	Verified	2.2950036163911	0.010866458523532	no	135	0.0270332152391338	199	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL DIVISION|VACUOLAR TRANSPORT	GOLGI APPARATUS		Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; links the (VFT/GARP) complex to the SNARE Tlg1p	vesicle organization|retrograde transport, endosome to Golgi|budding cell apical bud growth|regulation of cell size|protein targeting to vacuole	protein binding	Golgi apparatus|GARP complex
YPL023C	YPL023C	MET12	hom	Verified	2.28564341808707	0.0111375639612185	no	136	0.0125650909887164	90	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS			Protein with methylenetetrahydrofolate reductase (MTHFR) activity in vitro; null mutant has no phenotype and is prototrophic for methionine; MET13 encodes major isozyme of MTHFR	biological_process	methylenetetrahydrofolate reductase (NADPH) activity	cellular_component
YBR125C	YBR125C	PTC4	hom	Verified	2.28335989133656	0.0112045889036702	no	137	0.00550890551752857	69	NA					Cytoplasmic type 2C protein phosphatase (PP2C); identified as a high-copy number suppressor of cnb1 mpk1 synthetic lethality; overexpression decreases high-osmolarity induced Hog1p phosphorylation and kinase activity	protein dephosphorylation	protein serine/threonine phosphatase activity	cytoplasm
YIL056W	YIL056W	VHR1	hom	Verified	2.27609713700781	0.0114200982032628	no	138	0.00431401568561917	64	NA	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Transcriptional activator; required for the vitamin H-responsive element (VHRE) mediated induction of VHT1 (Vitamin H transporter) and BIO5 (biotin biosynthesis intermediate transporter) in response to low biotin concentrations; VHR1 has a paralog, VHR2, that arose from the whole genome duplication	regulation of transcription from RNA polymerase II promoter in response to biotin starvation|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity	nucleus|cytoplasm
YDL095W	YDL095W	PMT1	hom	Verified	2.27320506592013	0.0115069125826026	no	139	0.0231035149979502	116	NA	FT	PROTEIN LOCALIZATION|CARBOHYDRATE METABOLISM|PROTEOLYSIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein O-mannosyltransferase of the ER membrane; transfers mannose from dolichyl phosphate-D-mannose to protein serine and threonine residues; 1 of 7 related proteins involved in O-glycosylation which is essential for cell wall rigidity; involved in ER quality control; amino terminus faces cytoplasm, carboxyl terminus faces ER lumen	ER-associated misfolded protein catabolic process|Unknown|protein exit from endoplasmic reticulum|protein O-linked mannosylation	dolichyl-phosphate-mannose-protein mannosyltransferase activity	integral to membrane|dolichyl-phosphate-mannose-protein mannosyltransferase complex
YIL105C	YIL105C	SLM1	hom	Verified	2.27074570583453	0.0115811882127977	no	140	0.0108496864180976	104	NA	FT	VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|SIGNALING|CYTOSKELETON ORGANIZATION	MITOCHONDRION|PLASMA MEMBRANE		Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm2p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; phosphorylated by the TORC2 complex; protein abundance increases in response to DNA replication stress; SLM1 has a paralog, SLM2, that arose from the whole genome duplication	eisosome assembly|TOR signaling cascade|regulation of cell growth|actin filament bundle assembly|endosomal transport|establishment or maintenance of actin cytoskeleton polarity|actin cytoskeleton organization	phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol binding|sphingolipid binding	eisosome|mitochondrion|membrane raft|plasma membrane|cytoplasm
YJL055W_p	YJL055W	YJL055W	hom	Uncharacterized	2.26323826503415	0.0118105027923689	no	141	0.0123504967650805	109	NA	FT		NUCLEUS		Putative protein of unknown function, proposed to be involved in the metabolism of purine and pyrimidine base analogues; deletion mutants are sensitive to HAP and AHA; overexpression confers resistance to 5-FOA and 5-FU	response to chemical stimulus|response to purine-containing compound	molecular_function	nucleus|cytoplasm
YPR007C	YPR007C	REC8	hom	Verified	2.2564972048967	0.0120197550786117	no	142	0.0124244345611298	79	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME		Meiosis-specific component of sister chromatid cohesion complex; maintains cohesion between sister chromatids during meiosis I; maintains cohesion between centromeres of sister chromatids until meiosis II; homolog of S. pombe Rec8p	synaptonemal complex assembly|protein localization to chromosome, centromeric region|reciprocal meiotic recombination|meiotic sister chromatid cohesion	molecular_function	condensed nuclear chromosome|condensed nuclear chromosome, centromeric region
YDR135C	YDR135C	YCF1	hom	Verified	2.25328941621088	0.0121204533257548	no	143	0.00733312385038266	85	NA	FT	NUCLEOTIDE METABOLISM			Vacuolar glutathione S-conjugate transporter; member of the ATP-binding cassette family; has a role in detoxifying metals such as cadmium, mercury, and arsenite; also transports unconjugated bilirubin, selenodigluthatione, and oxidized glutathione; similar to human cystic fibrosis protein CFTR	bilirubin transport|response to metal ion|transmembrane transport	bilirubin transmembrane transporter activity|glutathione S-conjugate-exporting ATPase activity	fungal-type vacuole membrane|integral to membrane
YLL054C_p	YLL054C	YLL054C	hom	Uncharacterized	2.2528928779077	0.0121329520212024	no	144	0.0145190241562796	82	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Putative protein of unknown function with similarity to Pip2p, an oleate-specific transcriptional activator of peroxisome proliferation; YLL054C is not an essential gene	biological_process	sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity	cellular_component
YJL129C	YJL129C	TRK1	hom	Verified	2.24860362218014	0.01226886288367	no	145	0.0295158710233314	224	NA	FF|FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Component of the Trk1p-Trk2p potassium transport system; 180 kDa high affinity potassium transporter; phosphorylated in vivo and interacts physically with the phosphatase Ppz1p, suggesting Trk1p acitivy is regulated by phosphorylation; TRK1 has a paralog, TRK2, that arose from the whole genome duplication	cellular potassium ion homeostasis	potassium ion transmembrane transporter activity	membrane raft|integral to membrane|plasma membrane
YNL071W	YNL071W	LAT1	hom	Verified	2.2422304565485	0.0124732408491311	no	146	0.0166714028138292	155	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Dihydrolipoamide acetyltransferase component (E2) of pyruvate dehydrogenase complex, which catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA	acetyl-CoA biosynthetic process from pyruvate	dihydrolipoyllysine-residue acetyltransferase activity	mitochondrion|mitochondrial pyruvate dehydrogenase complex
YJR082C	YJR082C	EAF6	hom	Verified	2.22733475112725	0.0129624548257153	no	147	0.00717077937296898	90	NA	FT	CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE	NUCLEUS	HISTONE ACETYLTRANSFERASE	Subunit of the NuA4 acetyltransferase complex that acetylates histone H4 and NuA3 acetyltransferase complex that acetylates histone H3	DNA repair|histone acetylation	histone acetyltransferase activity	nucleus|NuA4 histone acetyltransferase complex|NuA3 histone acetyltransferase complex
YLR431C	YLR431C	ATG23	hom	Verified	2.21477485924283	0.0133877608328618	no	148	0.0177435310318539	139	NA	FT	PROTEIN LOCALIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS			Peripheral membrane protein required for the cytoplasm-to-vacuole targeting (Cvt) pathway and efficient macroautophagy; cycles between the phagophore assembly site (PAS) and non-PAS locations; forms a complex with Atg9p and Atg27p	protein localization to pre-autophagosomal structure|positive regulation of macroautophagy|CVT pathway	molecular_function	pre-autophagosomal structure|extrinsic to membrane
YLR288C	YLR288C	MEC3	hom	Verified	2.2125057135398	0.0134658709306967	no	149	0.00702649805673214	66	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|GENE SILENCING	NUCLEUS|CHROMOSOME		DNA damage and meiotic pachytene checkpoint protein; subunit of a heterotrimeric complex (Rad17p-Mec3p-Ddc1p) that forms a sliding clamp, loaded onto partial duplex DNA by a clamp loader complex; homolog of human and S. pombe Hus1	telomere maintenance via recombination|DNA damage checkpoint|DNA metabolic process|chromatin silencing at telomere	DNA binding	nucleus|checkpoint clamp complex
YLR439W	YLR439W	MRPL4	hom	Verified	2.2061825015145	0.0136856119855775	no	150	0.0290455269644301	167	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit, homolog of prokaryotic L29 ribosomal protein; located at the ribosomal tunnel exit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YNL307C	YNL307C	MCK1	hom	Verified	2.20607421255161	0.0136894019761867	no	151	0.0225478549574943	172	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION|CHROMOSOME SEGREGATION			Protein serine/threonine/tyrosine (dual-specificity) kinase; involved in control of chromosome segregation and in regulating entry into meiosis; interacts with Clb2p and Mih1p; inhibits Clb2p-Cdk1 activity; related to mammalian glycogen synthase kinases of the GSK-3 family	meiosis|double-strand break repair via nonhomologous end joining|ascospore formation|protein phosphorylation|response to stress|mitotic sister chromatid segregation	protein serine/threonine/tyrosine kinase activity|protein serine/threonine kinase activity|protein kinase activity	cellular_component
YOR066W	YOR066W	MSA1	hom	Verified	2.2051658388365	0.0137212296967294	no	152	0.0114342191228011	125	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE	NUCLEUS		Activator of G1-specific transcription factors, MBF and SBF; involved in regulation of the timing of G1-specific gene transcription and cell cycle initiation; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation	G1/S transition of mitotic cell cycle|regulation of transcription involved in G1 phase of mitotic cell cycle|regulation of cell size	molecular_function	nucleus|cytoplasm
YHR160C	YHR160C	PEX18	hom	Verified	2.20372229027047	0.0137719402798167	no	153	0.0159888545062607	149	NA	FT	PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION			Peroxin required for targeting of peroxisomal matrix proteins containing PTS2; interacts with Pex7p; partially redundant with Pex21p	protein import into peroxisome matrix	protein binding	cytosol|peroxisome
YLR427W	YLR427W	MAG2	hom	Verified	2.19923485325892	0.0139306136382205	no	154	0.0208518462767159	125	NA					Cytoplasmic protein of unknown function; induced in response to mycotoxin patulin; ubiquitinated protein similar to the human ring finger motif protein RNF10; predicted to be involved in repair of alkylated DNA due to interaction with MAG1	biological_process	molecular_function	cytoplasm
YGL021W	YGL021W	ALK1	hom	Verified	2.19609708044013	0.0140424977613519	no	155	0.0139704773079906	80	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION			Protein kinase; accumulation and phosphorylation are periodic during the cell cycle; phosphorylated in response to DNA damage; contains characteristic motifs for degradation via the APC pathway; ALK1 has a paralog, ALK2, that arose from the whole genome duplication; similar to mammalian haspins	mitosis|protein phosphorylation	protein serine/threonine kinase activity|protein kinase activity	cellular_component
YKL120W	YKL120W	OAC1	hom	Verified	2.19375008693607	0.0141266904430682	no	156	0.0128745900724354	94	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Mitochondrial inner membrane transporter, transports oxaloacetate, sulfate, thiosulfate, and isopropylmalate; member of the mitochondrial carrier family	sulfate transport|oxaloacetate transport|isopropylmalate transport	secondary active sulfate transmembrane transporter activity|oxaloacetate secondary active transmembrane transporter activity|isopropylmalate transmembrane transporter activity	mitochondrion|integral to membrane|mitochondrial inner membrane
YKL212W	YKL212W	SAC1	hom	Verified	2.19344120659919	0.0141378030974545	no	157	0.07440932421793	432	NA	FF|FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION|GOLGI APPARATUS		Phosphatidylinositol phosphate (PtdInsP) phosphatase; involved in hydrolysis of PtdIns[4]P in the early and medial Golgi; regulated by interaction with Vps74p; ER localized transmembrane protein which cycles through the Golgi; involved in protein trafficking and processing, secretion, and cell wall maintenance; regulates sphingolipid biosynthesis through the modulation of PtdIns(4)P metabolism	phosphatidylinositol dephosphorylation	phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity|phosphatidylinositol-3-phosphatase activity|phosphatidylinositol-4-phosphate phosphatase activity	mitochondrial outer membrane|integral to endoplasmic reticulum membrane|mitochondrion|SPOTS complex|integral to Golgi membrane
YAL007C	YAL007C	ERP2	hom	Verified	2.17765310470104	0.0147159363576243	no	158	0.0140459083812497	98	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein that forms a heterotrimeric complex with Erp1p, Emp24p, and Erv25p; member, along with Emp24p and Erv25p, of the p24 family involved in ER to Golgi transport and localized to COPII-coated vesicles	ER to Golgi vesicle-mediated transport	molecular_function	ER to Golgi transport vesicle
YGL148W	YGL148W	ARO2	hom	Verified	2.17722491524504	0.0147318951021664	no	159	0.0596732865273329	367	NA	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM			Bifunctional chorismate synthase and flavin reductase; catalyzes the conversion of 5-enolpyruvylshikimate 3-phosphate (EPSP) to form chorismate, which is a precursor to aromatic amino acids; protein abundance increases in response to DNA replication stress	aromatic amino acid family biosynthetic process	chorismate synthase activity|riboflavin reductase (NADPH) activity	cytoplasm
YGR168C_p	YGR168C	YGR168C	hom	Uncharacterized	2.17621535995664	0.0147695804569302	no	160	0.0301334207454324	169	NA					Putative protein of unknown function; YGR168C is not an essential gene	biological_process	molecular_function	integral to membrane
YMR075C-A_d	YMR075C-A	YMR075C-A	hom	Dubious	2.17300283147107	0.0148900520890316	no	161	0.0153880633274006	101	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF RCO1/YMR075W	Unknown	Unknown	Unknown
YBR006W	YBR006W	UGA2	hom	Verified	2.16790971748922	0.0150827781802966	no	162	0.0187132402219475	199	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS			Succinate semialdehyde dehydrogenase involved in the utilization of gamma-aminobutyrate (GABA) as a nitrogen source; part of the 4-aminobutyrate and glutamate degradation pathways; localized to the cytoplasm	cellular response to oxidative stress|gamma-aminobutyric acid catabolic process|glutamate decarboxylation to succinate	succinate-semialdehyde dehydrogenase [NAD(P)+] activity	cytoplasm
YAR018C	YAR018C	KIN3	hom	Verified	2.16443396569831	0.0152155297094406	no	163	0.021254426593328	111	NA	FT	PROTEIN PHOSPHORYLATION|CHROMOSOME SEGREGATION			Nonessential serine/threonine protein kinase; possible role in DNA damage response	chromosome segregation|protein phosphorylation	protein kinase activity	cellular_component
YER046W	YER046W	SPO73	hom	Verified	2.16337664106799	0.0152561113442748	no	164	0.0118282862333514	99	NA	FT	CELL WALL ORG/BIOGENESIS			Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensible for both nuclear divisions during meiosis	ascospore wall assembly|ascospore formation	molecular_function	cytosol
YMR065W	YMR065W	KAR5	hom	Verified	2.15655320124522	0.0155202471387318	no	165	0.0149898327508923	118	NA	FT		ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|MITOCHONDRION		Protein required for nuclear membrane fusion during karyogamy, localizes to the membrane with a soluble portion in the endoplasmic reticulum lumen, may form a complex with Jem1p and Kar2p; expression of the gene is regulated by pheromone	karyogamy involved in conjugation with cellular fusion	molecular_function	mitochondrion|endoplasmic reticulum membrane
YDR035W	YDR035W	ARO3	hom	Verified	2.15234278238548	0.0156851832996207	no	166	0.0692901334799139	411	NA	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS|MITOCHONDRION		3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase, catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by phenylalanine or high concentration of tyrosine or tryptophan	aromatic amino acid family biosynthetic process	3-deoxy-7-phosphoheptulonate synthase activity	mitochondrion|nucleus|cytoplasm
YOR147W	YOR147W	MDM32	hom	Verified	2.15091300911647	0.0157415332653664	no	167	0.0168675457535571	127	NA	FT	ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS	MITOCHONDRION		Mitochondrial inner membrane protein with similarity to Mdm31p, required for normal mitochondrial morphology and inheritance; interacts genetically with MMM1, MDM10, MDM12, and MDM34	mitochondrion inheritance|cellular ion homeostasis|mitochondrion organization	molecular_function	mitochondrion|mitochondrial inner membrane
YJR061W_p	YJR061W	YJR061W	hom	Uncharacterized	2.14884056678564	0.0158235202141994	no	168	0.0159672537689279	126	NA					Putative protein of unknown function; non-essential gene; transcription repressed by Rm101p; YJR061W has a paralog, MNN4, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YJL120W_d	YJL120W	YJL120W	hom	Dubious	2.14423218165408	0.0160071438552827	no	169	0.0465931128923503	303	NA	FF				Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL121C/RPE1; deletion confers sensitivity to GSAO	Unknown	Unknown	Unknown
YER011W	YER011W	TIR1	hom	Verified	2.14057228685911	0.016154272815876	no	170	0.0102405891545959	83	NA					Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expression is downregulated at acidic pH and induced by cold shock and anaerobiosis; abundance is increased in cells cultured without shaking	response to stress	structural constituent of cell wall	fungal-type cell wall
YPR040W	YPR040W	TIP41	hom	Verified	2.13069539835644	0.0165571222172434	no	171	0.0228240574454806	184	NA	FT	SIGNALING	NUCLEUS		Protein that interacts with Tap42p, which regulates PP2A; component of the TOR (target of rapamycin) signaling pathway; protein abundance increases in response to DNA replication stress	signal transduction	molecular_function	nucleus|cytoplasm
YPR159W	YPR159W	KRE6	hom	Verified	2.12442389872124	0.0168173566784014	no	172	0.031578621663752	153	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Type II integral membrane protein required for beta-1,6 glucan biosynthesis; putative beta-glucan synthase; localizes to the ER, plasma membrane, sites of polarized growth and secretory vesicles; functionally redundant with Skn1p	fungal-type cell wall organization|(1->6)-beta-D-glucan biosynthetic process	glucosidase activity	integral to endoplasmic reticulum membrane|integral to membrane|site of polarized growth|transport vesicle|plasma membrane
YOR173W	YOR173W	DCS2	hom	Verified	2.11428877187899	0.0172453053863761	no	173	0.017017354275919	112	NA					Non-essential, stress induced regulatory protein; modulates m7G-oligoribonucleotide metabolism; inhibits Dcs1p; regulated by Msn2p, Msn4p, and the Ras-cAMP-cAPK signaling pathway; mutant has increased aneuploidy tolerance	deadenylation-dependent decapping of nuclear-transcribed mRNA	m7G(5')pppN diphosphatase activity	cytoplasmic mRNA processing body|cytoplasm
YGR034W	YGR034W	RPL26B	hom	Verified	2.11383937918283	0.0172644941550977	no	174	0.0259755500197344	143	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L26B; binds to 5.8S rRNA; homologous to mammalian ribosomal protein L26 and bacterial L24; RPL26B has a paralog, RPL26A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome|RNA binding	cytosolic large ribosomal subunit
YBR182C-A_p	YBR182C-A	YBR182C-A	hom	Uncharacterized	2.11172692545585	0.0173549390926848	no	175	0.0207560776231842	148	NA					Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching	biological_process	molecular_function	cellular_component
YDR134C	YDR134C	YDR134C	hom	pseudogene	2.09763118827404	0.0179688688971389	no	176	0.0120526334363563	85	NA					Hypothetical protein; YDR134C has a paralog, CCW12, that arose from the whole genome duplication	biological_process	molecular_function	fungal-type cell wall
YKL183W	YKL183W	LOT5	hom	Verified	2.09178640379314	0.018228813572089	no	177	0.0123174737822951	111	NA	FT		NUCLEUS		Protein of unknown function; gene expression increases in cultures shifted to a lower temperature; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	nucleus|cytoplasm
YER073W	YER073W	ALD5	hom	Verified	2.0908194043154	0.0182721279934049	no	178	0.0212025014094742	132	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS	MITOCHONDRION		Mitochondrial aldehyde dehydrogenase, involved in regulation or biosynthesis of electron transport chain components and acetate formation; activated by K+; utilizes NADP+ as the preferred coenzyme; constitutively expressed	acetate biosynthetic process	aldehyde dehydrogenase [NAD(P)+] activity	mitochondrion
YJL153C	YJL153C	INO1	hom	Verified	2.08370633965722	0.018593443606863	no	179	0.0227163395474412	113	NA	FT	LIPID METABOLISM|CARBOHYDRATE METABOLISM			Inositol-3-phosphate synthase, involved in synthesis of inositol phosphates and inositol-containing phospholipids; transcription is coregulated with other phospholipid biosynthetic genes by Ino2p and Ino4p, which bind the UASINO DNA element	inositol biosynthetic process	inositol-3-phosphate synthase activity	cytoplasm
YPR122W	YPR122W	AXL1	hom	Verified	2.08166029746532	0.0186867547668029	no	180	0.0145532005219776	132	NA	FT	CELL CYCLE|CELL DIVISION|PROTEOLYSIS	SITE OF POLARIZED GROWTH		Haploid specific endoprotease that performs one of two N-terminal cleavages during maturation of a-factor mating pheromone; required for axial budding pattern of haploid cells	peptide pheromone maturation|axial cellular bud site selection	metalloendopeptidase activity	mating projection tip|cellular bud neck
YPR046W	YPR046W	MCM16	hom	Verified	2.08117333356557	0.0187090217167126	no	181	0.0377079742279237	226	NA	FT	CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME	KINETOCHORE	Component of the Ctf19 complex and the COMA subcomplex; involved in kinetochore-microtubule mediated chromosome segregation; binds to centromere DNA; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-H and fission yeast fta3	chromosome segregation|establishment of mitotic sister chromatid cohesion	molecular_function	condensed nuclear chromosome kinetochore
YGL170C	YGL170C	SPO74	hom	Verified	2.07889282169485	0.0188136013254083	no	182	0.0202798664005663	143	NA	FT		NUCLEUS|CYTOSKELETON		Component of the meiotic outer plaque of the spindle pole body, involved in modifying the meiotic outer plaque that is required prior to prospore membrane formation	ascospore formation	structural molecule activity	spindle pole body
YJR154W_p	YJR154W	YJR154W	hom	Uncharacterized	2.07329949046029	0.0190722080508887	no	183	0.0131092818361272	99	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	biological_process	molecular_function	cytoplasm
YOR308C	YOR308C	SNU66	hom	Verified	2.07304071360349	0.0190842453546364	no	184	0.0199792394693949	104	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Component of the U4/U6.U5 snRNP complex involved in pre-mRNA splicing via spliceosome; also required for pre-5S rRNA processing and may act in concert with Rnh70p; has homology to human SART-1	maturation of 5S rRNA|mRNA splicing, via spliceosome	molecular_function	U4/U6 x U5 tri-snRNP complex
YBR244W	YBR244W	GPX2	hom	Verified	2.07247495539896	0.0191105847509477	no	185	0.0122799364993489	125	NA	FT	OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS	NUCLEUS|MITOCHONDRION		Phospholipid hydroperoxide glutathione peroxidase; protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress; induced by glucose starvation; protein abundance increases in response to DNA replication stress	cellular response to oxidative stress	phospholipid-hydroperoxide glutathione peroxidase activity|glutathione peroxidase activity	extrinsic to mitochondrial inner membrane|extrinsic to mitochondrial outer membrane|nucleus|cytoplasm
YDL162C_d	YDL162C	YDL162C	hom	Dubious	2.07116453344763	0.0191717113825468	no	186	0.016406825811197	109	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps ENT1/YDL161W, a verified gene involved in endocytosis and actin cortical patch assembly	Unknown	Unknown	Unknown
YLR052W	YLR052W	IES3	hom	Verified	2.06871285163436	0.0192865202491839	no	187	0.0244257508219911	174	NA	FT	CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS|CHROMOSOME		Subunit of the INO80 chromatin remodeling complex	nucleosome mobilization|telomere maintenance|chromatin silencing at telomere	molecular_function	nucleus|Ino80 complex
YHR146W	YHR146W	CRP1	hom	Verified	2.06533987358286	0.0194454266499102	no	188	0.0260917115558563	170	NA	FT		NUCLEUS		Protein that binds to cruciform DNA structures	biological_process	DNA binding	nucleus
YHR006W	YHR006W	STP2	hom	Verified	2.06067262151872	0.0196671416530971	no	189	0.0136284597934132	108	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS|PLASMA MEMBRANE		Transcription factor; activated by proteolytic processing in response to signals from the SPS sensor system for external amino acids; activates transcription of amino acid permease genes; STP2 has a paralog, STP1, that arose from the whole genome duplication	positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus|cytoplasm
YOL076W	YOL076W	MDM20	hom	Verified	2.05811979664844	0.0197893175508422	no	190	0.0342016564152821	288	NA	FF|FT	MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION			Non-catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes N-acetylation of proteins with specific N-terminal sequences; involved in mitochondrial inheritance and actin assembly	mitochondrion inheritance|N-terminal peptidyl-methionine acetylation|cytoskeleton organization	peptide alpha-N-acetyltransferase activity	NatB complex
YER034W	YER034W	YER034W	hom	Verified	2.05495052117989	0.0199418920003353	no	191	0.0244227905388958	130	NA	FT		NUCLEUS		Protein of unknown function; non-essential gene; expression induced upon calcium shortage; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	nucleus|cytoplasm
YPR188C	YPR188C	MLC2	hom	Verified	2.05484944639475	0.0199467742943106	no	192	0.0177765976340857	105	NA	FT	CELL CYCLE|CELL DIVISION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Regulatory light chain for the type II myosin, Myo1p; binds to an IQ motif of Myo1p, localization to the bud neck depends on Myo1p; involved in the disassembly of the Myo1p ring	actomyosin contractile ring contraction	myosin II binding	cellular bud neck contractile ring
YDL062W_d	YDL062W	YDL062W	hom	Dubious	2.05406361335617	0.0199847676040162	no	193	0.0214804554427166	130	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized ORF YDL063C; YDL062W is not essential	Unknown	Unknown	Unknown
YLR084C	YLR084C	RAX2	hom	Verified	2.05190656673848	0.0200893717783574	no	194	0.0280400061507329	94	NA	FT	CELL CYCLE|CELL DIVISION	MITOCHONDRION|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		N-glycosylated protein involved in the maintenance of bud site selection during bipolar budding; localization requires Rax1p; RAX2 mRNA stability is regulated by Mpt5p	cellular bud site selection	molecular_function	mitochondrion|cellular bud scar|cellular bud neck|membrane
YDR137W	YDR137W	RGP1	hom	Verified	2.04790642624992	0.0202845845384414	no	195	0.0792928052951966	319	NA	FF|FT	VESICLE-MEDIATED TRANSPORT|CELL CYCLE|CELL DIVISION	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) that catalyzes nucleotide exchange on Ypt6p	retrograde transport, endosome to Golgi	guanyl-nucleotide exchange factor activity	Golgi apparatus|Ric1p-Rgp1p complex|Golgi membrane|guanyl-nucleotide exchange factor complex
YBR039W	YBR039W	ATP3	hom	Verified	2.04460363213384	0.0204469755671434	no	196	0.0310419721164279	225	NA	FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS	MITOCHONDRION		Gamma subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis	ATP synthesis coupled proton transport	proton-transporting ATPase activity, rotational mechanism	mitochondrion|integral to membrane|mitochondrial proton-transporting ATP synthase, central stalk
YHR126C_p	YHR126C	ANS1	hom	Uncharacterized	2.04228288452374	0.0205617394313861	no	197	0.0192443408188315	122	NA	FT		PLASMA MEMBRANE		Putative GPI protein; transcription dependent upon Azf1p	biological_process	molecular_function	cellular_component
YJL116C	YJL116C	NCA3	hom	Verified	2.03747480408854	0.0208012421738269	no	198	0.0144516284703021	92	NA	FT	MITOCHONDRION ORGANIZATION	MITOCHONDRION		Protein involved in mitochondrion organization; functions with Nca2p to regulate mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p) of the Fo-F1 ATP synthase; member of the SUN family; expression induced in cells treated with the mycotoxin patulin; NCA3 has a paralog, UTH1, that arose from the whole genome duplication	mitochondrion organization	molecular_function	cellular_component
YMR026C	YMR026C	PEX12	hom	Verified	2.03713085646456	0.0208184652386071	no	199	0.0303132561181733	133	NA	FT	PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION			C3HC4-type RING-finger peroxin and E3 ubiquitin ligase, required for peroxisome biogenesis and peroxisomal matrix protein import; forms translocation subcomplex with Pex2p and Pex10p; mutations in human homolog cause peroxisomal disorder	protein import into peroxisome matrix	ubiquitin-protein ligase activity|protein binding	integral to peroxisomal membrane
YBR015C	YBR015C	MNN2	hom	Verified	2.03650165520675	0.0208500035316275	no	200	0.0412404371090542	289	NA	FF|FT	CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Alpha-1,2-mannosyltransferase, responsible for addition of the first alpha-1,2-linked mannose to form the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment	protein glycosylation	alpha-1,2-mannosyltransferase activity	Golgi apparatus
YDL075W	YDL075W	RPL31A	hom	Verified	2.02429652110077	0.0214698256863413	no	201	0.0383673686770081	200	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L31A; associates with karyopherin Sxm1p; loss of both Rpl31p and Rpl39p confers lethality; homologous to mammalian ribosomal protein L31, no bacterial homolog; RPL31A has a paralog, RPL31B, that arose from the whole genome duplication	cytoplasmic translation|regulation of translational fidelity	structural constituent of ribosome	cytosolic large ribosomal subunit
YBL069W	YBL069W	AST1	hom	Verified	2.01225757888436	0.0220963958499555	no	202	0.0203099367244626	164	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|OXIDATION-REDUCTION PROCESS	GOLGI APPARATUS|PLASMA MEMBRANE		Lipid raft associated protein; interacts with the plasma membrane ATPase Pma1p and has a role in its targeting to the plasma membrane by influencing its incorporation into lipid rafts; sometimes classified in the medium-chain dehydrogenase/reductases (MDRs) superfamily; AST1 has a paralog, AST2, that arose from the whole genome duplication	protein targeting to membrane|protein transport into membrane raft	molecular_function	late endosome|membrane raft|Golgi apparatus|plasma membrane
YMR158W	YMR158W	MRPS8	hom	Verified	2.01135356326807	0.0221440622800033	no	203	0.0208597311506702	163	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the small subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YPR015C_p	YPR015C	YPR015C	hom	Uncharacterized	2.01125559735763	0.0221492329794875	no	204	0.0266259841747129	119	NA					Putative protein of unknown function; overexpression causes a cell cycle delay or arrest	biological_process	sequence-specific DNA binding	cellular_component
YOL098C_p	YOL098C	YOL098C	hom	Uncharacterized	2.00899084437001	0.0222690523557253	no	205	0.021622269511404	170	NA	FT	PROTEOLYSIS			Putative metalloprotease	biological_process	molecular_function	cytoplasm
YGL156W	YGL156W	AMS1	hom	Verified	2.00610343233012	0.0224226068714206	no	206	0.0204430251203837	101	NA	FT	CARBOHYDRATE METABOLISM			Vacuolar alpha mannosidase, involved in free oligosaccharide (fOS) degradation; delivered to the vacuole in a novel pathway separate from the secretory pathway	oligosaccharide catabolic process|cellular carbohydrate metabolic process	alpha-mannosidase activity	fungal-type vacuole membrane
YOR307C	YOR307C	SLY41	hom	Verified	2.00605934518545	0.0224249583596898	no	207	0.0248542998708638	141	NA	FT	VESICLE-MEDIATED TRANSPORT	ENDOPLASMIC RETICULUM		Protein involved in ER-to-Golgi transport	ER to Golgi vesicle-mediated transport	molecular_function	integral to membrane|endoplasmic reticulum
YPR050C_d	YPR050C	YPR050C	hom	Dubious	1.99912626397177	0.0227973470363246	no	208	0.0426258579229826	222	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene MAK3/YPR051W	Unknown	Unknown	Unknown
YOR018W	YOR018W	ROD1	hom	Verified	1.99731064457623	0.0228957238689578	no	209	0.0149841279330554	119	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION	PLASMA MEMBRANE		Membrane protein, binds the ubiquitin ligase Rsp5p via its 2 PY motifs; overexpression confers resistance to the GST substrate o-dinitrobenzene, zinc, and calcium; proposed to regulate the endocytosis of plasma membrane proteins; protein abundance increases in response to DNA replication stress; ROD1 has a paralog, ROG3, that arose from the whole genome duplication	response to drug|ubiquitin-dependent endocytosis	ubiquitin protein ligase binding	plasma membrane
YNL069C	YNL069C	RPL16B	hom	Verified	1.99559911766157	0.0229887878261633	no	210	0.0364503029951683	193	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L16B; N-terminally acetylated, binds 5.8 S rRNA; transcriptionally regulated by Rap1p; homologous to mammalian ribosomal protein L13A and bacterial L13; RPL16B has a paralog, RPL16A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome|RNA binding	cytosolic large ribosomal subunit
YHR008C	YHR008C	SOD2	hom	Verified	1.99526968998266	0.023006736910339	no	211	0.0629448665211326	274	NA	FF|FT	OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS	MITOCHONDRION		Mitochondrial manganese superoxide dismutase, protects cells against oxygen toxicity; phosphorylated	reactive oxygen species metabolic process|age-dependent response to oxidative stress involved in chronological cell aging|replicative cell aging|age-dependent response to reactive oxygen species involved in chronological cell aging	superoxide dismutase activity	mitochondrion|mitochondrial matrix
YJL158C	YJL158C	CIS3	hom	Verified	1.9934981236991	0.0231034643973532	no	212	0.0165858019318446	112	NA	FT	CELL WALL ORG/BIOGENESIS	ENDOPLASMIC RETICULUM|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Mannose-containing glycoprotein constituent of the cell wall; member of the PIR (proteins with internal repeats) family	fungal-type cell wall organization	structural constituent of cell wall	extracellular region|fungal-type cell wall|endoplasmic reticulum|plasma membrane|cellular bud tip
YOR109W	YOR109W	INP53	hom	Verified	1.99228189504896	0.0231700685171684	no	213	0.0209335468975146	165	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|MEMBRANE ORGANIZATION	CYTOSKELETON		Polyphosphatidylinositol phosphatase, dephosphorylates multiple phosphatidylinositols; involved in trans Golgi network-to-early endosome pathway; hyperosmotic stress causes translocation to actin patches; contains Sac1 and 5-ptase domains	phosphatidylinositol dephosphorylation	phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|phosphatidylinositol-3-phosphatase activity|phosphatidylinositol-4-phosphate phosphatase activity	membrane|actin cortical patch|cytoplasm
YBR196C-B_p	YBR196C-B	YBR196C-B	hom	Uncharacterized	1.99022321711065	0.0232831759270972	no	214	0.0177372316106637	135	NA					Putative protein of unknown function; identified by expression profiling and mass spectrometry	biological_process	molecular_function	cellular_component
YDL240W	YDL240W	LRG1	hom	Verified	1.98646571170196	0.0234908182318806	no	215	0.0238186076554583	156	NA	FT	SIGNALING|CELL WALL ORG/BIOGENESIS	MITOCHONDRION|SITE OF POLARIZED GROWTH		Putative GTPase-activating protein (GAP) involved in the Pkc1p-mediated signaling pathway that controls cell wall integrity; appears to specifically regulate 1,3-beta-glucan synthesis	fungal-type cell wall biogenesis|small GTPase mediated signal transduction	Rho GTPase activator activity	mitochondrion|cellular bud neck|cytoplasm
YPL141C	YPL141C	FRK1	hom	Verified	1.98392078111576	0.0236323359324606	no	216	0.0223145218430648	183	NA	FT	PROTEIN PHOSPHORYLATION			Protein kinase of unknown cellular role; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; interacts with rRNA transcription and ribosome biogenesis factors and the long chain fatty acyl-CoA synthetase Faa3p; FRK1 has a paralog, KIN4, that arose from the whole genome duplication	protein phosphorylation	protein kinase activity	cytoplasm
YDR176W	YDR176W	NGG1	hom	Verified	1.9839133310401	0.0236327512641661	no	217	0.0445396485555589	290	NA	FF|FT	CHROMATIN ORGANIZATION	NUCLEUS	HISTONE ACETYLTRANSFERASE	Transcriptional regulator involved in glucose repression of Gal4p-regulated genes; component of transcriptional adaptor and histone acetyltransferase complexes, the ADA complex, the SAGA complex, and the SLIK complex	histone acetylation|chromatin modification	histone acetyltransferase activity|transcription cofactor activity	SLIK (SAGA-like) complex|Ada2/Gcn5/Ada3 transcription activator complex|SAGA complex
YJL185C	YJL185C	ATG36	hom	Verified	1.97690708447089	0.0240260669435555	no	218	0.0196207268917687	145	NA					Pex3p interacting protein, required for pexophagy; interacts with Atg8p and Atg11p; mRNA is weakly cell cycle regulated, peaking in G2 phase; YJL185C is a non-essential gene	peroxisome degradation	molecular_function	peroxisome
YIL113W	YIL113W	SDP1	hom	Verified	1.97341976957824	0.0242238785316846	no	219	0.0292175745190783	174	NA	FT	SIGNALING|CELL WALL ORG/BIOGENESIS|PROTEIN PHOSPHORYLATION	NUCLEUS		Stress-inducible dual-specificity MAP kinase phosphatase, negatively regulates Slt2p MAP kinase by direct dephosphorylation, diffuse localization under normal conditions shifts to punctate localization after heat shock	inactivation of MAPK activity involved in cell wall biogenesis|MAPK cascade involved in cell wall biogenesis	MAP kinase tyrosine phosphatase activity	nucleus|cytoplasm
YOR385W_p	YOR385W	YOR385W	hom	Uncharacterized	1.96688203083089	0.0245984062974378	no	220	0.0255216016517684	186	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YOR385W is not an essential gene	biological_process	molecular_function	cytoplasm
YER014W	YER014W	HEM14	hom	Verified	1.96201716972463	0.0248802426562984	no	221	0.0397733964169148	201	NA	FT	OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM	MITOCHONDRION		Protoporphyrinogen oxidase, a mitochondrial enzyme that catalyzes the seventh step in the heme biosynthetic pathway, converting protoporphyrinogen IX to protoporphyrin IX; inhibited by diphenyl ether-type herbicides	heme biosynthetic process	oxygen-dependent protoporphyrinogen oxidase activity	mitochondrion|mitochondrial inner membrane
YNL227C	YNL227C	JJJ1	hom	Verified	1.95964633534464	0.025018570809404	no	222	0.0188710361565755	132	NA	FT	VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS|MITOCHONDRION	RIBOSOME	Co-chaperone that stimulates the ATPase activity of Ssa1p, required for a late step of ribosome biogenesis; associated with the cytosolic large ribosomal subunit; contains a J-domain; mutation causes defects in fluid-phase endocytosis	ribosomal subunit export from nucleus|ribosomal large subunit biogenesis|endocytosis|regulation of cell size|rRNA processing	ATPase activator activity	cytosol|mitochondrion|cytosolic large ribosomal subunit|nucleolus|cytoplasm
YBR062C_p	YBR062C	YBR062C	hom	Uncharacterized	1.95826797235832	0.0250992884348396	no	223	0.0162556488626147	112	NA					Protein of unknown function that interacts with Msb2p; may play a role in activation of the filamentous growth pathway.	biological_process	molecular_function	cellular_component
YGL210W	YGL210W	YPT32	hom	Verified	1.95764079833847	0.0251360882518064	no	224	0.0125595730828835	92	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING	ENDOMEMBRANE SYSTEM|MITOCHONDRION|GOLGI APPARATUS		Rab family GTPase involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; protein abundance increases in response to DNA replication stress; YPT32 has a paralog, YPT31, that arose from the whole genome duplication	early endosome to Golgi transport|vesicle-mediated transport|exocytosis	GTPase activity	endosome|mitochondrial outer membrane|Golgi apparatus
YKR035C_d	YKR035C	OPI8	hom	Dubious	1.9568531854882	0.025182365956668	no	225	0.047980057755182	231	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene DID2/YKR035W-A	Unknown	Unknown	Unknown
YLR311C_d	YLR311C	YLR311C	hom	Dubious	1.95445565240061	0.0253236773117063	no	226	0.0276674365118741	143	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDR520C_p	YDR520C	URC2	hom	Uncharacterized	1.95329029486492	0.0253926034205313	no	227	0.0411338375603731	117	NA	FT	TRANSCRIPTION FROM RNA POL II|NUCLEOTIDE METABOLISM	NUCLEUS		Putative Zn(II)2Cys6 motif containing transcription factor; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; similar to S. kluyveri Urc2p involved in uracil catabolism	uracil catabolic process	sequence-specific DNA binding	nucleus|cytoplasm
YMR246W	YMR246W	FAA4	hom	Verified	1.95323106062104	0.0253961110752686	no	228	0.0231082834083475	163	NA	FT	KETONE METABOLISM|LIPID METABOLISM|COFACTOR METABOLISM			Long chain fatty acyl-CoA synthetase; activates imported fatty acids with a preference for C12:0-C16:0 chain lengths; functions in long chain fatty acid import; important for survival during stationary phase; localized to lipid particles; involved in sphingolipid-to-glycerolipid metabolism; forms cytoplasmic foci upon DNA replication stress; FAA4 has a paralog, FAA1, that arose from the whole genome duplication	long-chain fatty acid transport|long-chain fatty-acyl-CoA metabolic process	long-chain fatty acid-CoA ligase activity	lipid particle|cytoplasm
YBR201W	YBR201W	DER1	hom	Verified	1.95147652705123	0.0255001929126581	no	229	0.0253745534928502	159	NA	FT	PROTEIN LOCALIZATION|PROTEOLYSIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	UBIQUITIN LIGASE COMPLEX	Endoplasmic reticulum membrane protein, required for ER-associated protein degradation of misfolded or unassembled proteins; N- and C- termini protrude into the cytoplasm, has similarity to Dfm1p	ER-associated protein catabolic process	molecular_function	integral to membrane|Hrd1p ubiquitin ligase ERAD-L complex|endoplasmic reticulum membrane
YOR002W	YOR002W	ALG6	hom	Verified	1.95066456212922	0.0255484807902993	no	230	0.0520357559071105	290	NA	FT	LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Alpha 1,3 glucosyltransferase, involved in transfer of oligosaccharides from dolichyl pyrophosphate to asparagine residues of proteins during N-linked protein glycosylation; mutations in human ortholog are associated with disease	oligosaccharide-lipid intermediate biosynthetic process|protein glycosylation|aerobic respiration	transferase activity, transferring hexosyl groups|dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity	integral to membrane|endoplasmic reticulum
YHR076W	YHR076W	PTC7	hom	Verified	1.9483816181719	0.0256846588148618	no	231	0.035693300719106	192	NA	FT		ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION		Type 2C protein phosphatase (PP2C); alternatively spliced to create two mRNA isoforms; protein from spliced form localizes to the mitochondria while the one from the unspliced form is localized to the nuclear envelope	biological_process	protein serine/threonine phosphatase activity	nuclear envelope|mitochondrion
YNR004W_p	YNR004W	SWM2	hom	Uncharacterized	1.94834048765612	0.0256871178188696	no	232	0.0234615663396514	159	NA	FT		NUCLEUS		Putative protein of unknown function; haploid disruptant exhibits cold-sensitive growth and elongated buds	biological_process	molecular_function	nucleolus
YKL070W_p	YKL070W	YKL070W	hom	Uncharacterized	1.9435421311514	0.0259753450291753	no	233	0.0179678553947438	111	NA	FT	OXIDATION-REDUCTION PROCESS	MITOCHONDRION		Putative protein of unknown function; expression induced in cells treated with mycotoxins patulin or citrinin; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YBR047W_p	YBR047W	FMP23	hom	Uncharacterized	1.9424595786063	0.0260407443870828	no	234	0.0233280907607517	146	NA	FT		MITOCHONDRION		Putative protein of unknown function; proposed to be involved in iron or copper homeostasis; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YIL009C-A	YIL009C-A	EST3	hom	Verified	1.94238657144713	0.0260451598614532	no	235	0.0320193607444148	174	NA	FT		NUCLEUS|CHROMOSOME		Component of the telomerase holoenzyme, involved in telomere replication	telomere maintenance via telomerase	ATP-dependent DNA/RNA helicase activity|GTPase activity|telomeric DNA binding	chromosome, telomeric region|nucleus|telomerase holoenzyme complex
YPL223C	YPL223C	GRE1	hom	Verified	1.94159557247997	0.0260930396535865	no	236	0.0323666057494245	148	NA					Hydrophilin essential in dessication-rehydration process; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway	biological_process	molecular_function	cytoplasm
YGL095C	YGL095C	VPS45	hom	Verified	1.9332755783342	0.0266011293169941	no	237	0.100356176649252	476	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Protein of the Sec1p/Munc-18 family, essential for vacuolar protein sorting; required for the function of Pep12p and the early endosome/late Golgi SNARE Tlg2p; essential for fusion of Golgi-derived vesicles with the prevacuolar compartment	vacuole inheritance|CVT pathway|positive regulation of SNARE complex assembly|Golgi vesicle fusion to target membrane|Golgi to vacuole transport|vacuole organization|vacuolar acidification|protein targeting to vacuole|Golgi to endosome transport	unfolded protein binding|SNARE binding	cytosol|SNARE complex|Golgi membrane|extrinsic to membrane
YDR241W_d	YDR241W	BUD26	hom	Dubious	1.9295873762574	0.0268289920990852	no	238	0.0336916384810808	209	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 1% of ORF overlaps the verified gene SNU56; diploid mutant displays a weak budding pattern phenotype in a systematic assay	Unknown	Unknown	Unknown
YFR054C_d	YFR054C	YFR054C	hom	Dubious	1.92907678183708	0.0268606654587305	no	239	0.0183752574494464	132	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YJL189W	YJL189W	RPL39	hom	Verified	1.92543095320515	0.0270877331534406	no	240	0.0313093240580577	139	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L39; required for ribosome biogenesis; loss of both Rpl31p and Rpl39p confers lethality; also exhibits genetic interactions with SIS1 and PAB1; homologous to mammalian ribosomal protein L39, no bacterial homolog	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YOL143C	YOL143C	RIB4	hom	Verified	1.92349645881347	0.0272088653987859	no	241	0.0312528715301684	163	NA	FT		NUCLEUS		Lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, also known as DMRL synthase); catalyzes synthesis of immediate precursor to riboflavin	riboflavin biosynthetic process	6,7-dimethyl-8-ribityllumazine synthase activity	nucleus|cytoplasm
YEL039C	YEL039C	CYC7	hom	Verified	1.90595409762218	0.0283280806847355	no	242	0.0407396088179941	205	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Cytochrome c isoform 2, expressed under hypoxic conditions; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration; protein abundance increases in response to DNA replication stress; CYC7 has a paralog, CYC1, that arose from the whole genome duplication	mitochondrial electron transport, cytochrome c to oxygen|mitochondrial electron transport, ubiquinol to cytochrome c	electron carrier activity	mitochondrion|mitochondrial intermembrane space
YOL088C	YOL088C	MPD2	hom	Verified	1.9048568185279	0.0283993428441321	no	243	0.0600129509149601	298	NA	FT		ENDOPLASMIC RETICULUM		Member of the protein disulfide isomerase (PDI) family, exhibits chaperone activity; overexpression suppresses the lethality of a pdi1 deletion but does not complement all Pdi1p functions; undergoes oxidation by Ero1p	protein folding	protein disulfide isomerase activity|protein disulfide oxidoreductase activity	endoplasmic reticulum
YOR162C	YOR162C	YRR1	hom	Verified	1.89905952460752	0.0287783250338534	no	244	0.0578446929391028	294	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		Zn2-Cys6 zinc-finger transcription factor; activates genes involved in multidrug resistance; paralog of Yrm1p, acting on an overlapping set of target genes; YRR1 has a paralog, PDR8, that arose from the whole genome duplication	regulation of transcription from RNA polymerase II promoter in response to oxidative stress|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity	nucleus
YCR011C	YCR011C	ADP1	hom	Verified	1.89261002887395	0.0292048745412436	no	245	0.0215921622456189	149	NA	FT	NUCLEOTIDE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Putative ATP-dependent permease of the ABC transporter family of proteins	transport|transmembrane transport	ATPase activity, coupled to transmembrane movement of substances	integral to membrane|endoplasmic reticulum|cytoplasm
YMR081C	YMR081C	ISF1	hom	Verified	1.89189374318128	0.0292525698012186	no	246	0.0213559221297685	145	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY			Serine-rich, hydrophilic protein with similarity to Mbr1p; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; expression is under glucose control; cotranscribed with NAM7 in a cyp1 mutant	aerobic respiration	molecular_function	cellular_component
YGR040W	YGR040W	KSS1	hom	Verified	1.89033014813498	0.0293569095614366	no	247	0.02183914065375	155	NA	FT	CELL CYCLE|SIGNALING|PROTEIN PHOSPHORYLATION	NUCLEUS		Mitogen-activated protein kinase (MAPK) involved in signal transduction pathways that control filamentous growth and pheromone response; the KSS1 gene is nonfunctional in S288C strains and functional in W303 strains	pheromone-dependent signal transduction involved in conjugation with cellular fusion|signal transduction involved in filamentous growth|negative regulation of sequence-specific DNA binding transcription factor activity|protein phosphorylation|invasive growth in response to glucose limitation	MAP kinase activity|protein kinase activity|transcription factor binding	nucleus
YJR121W	YJR121W	ATP2	hom	Verified	1.88995539296989	0.0293819630869068	no	248	0.026589507362935	158	NA	FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS	MITOCHONDRION		Beta subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated	ATP synthesis coupled proton transport	hydrogen ion transporting ATP synthase activity, rotational mechanism|ATPase activity|proton-transporting ATPase activity, rotational mechanism	proton-transporting ATP synthase complex, catalytic core F(1)|mitochondrion|mitochondrial proton-transporting ATP synthase, catalytic core|integral to membrane
YPL270W	YPL270W	MDL2	hom	Verified	1.88949953823544	0.029412462295511	no	249	0.0377252689456731	208	NA	FT	NUCLEOTIDE METABOLISM	MITOCHONDRION		Mitochondrial inner membrane half-type ATP-binding cassette (ABC) transporter, required for respiratory growth at high temperature; similar to human TAP1 and TAP2 implicated in bare lymphocyte syndrome and Wegener-like granulomatosis	oligopeptide transport|oligopeptide export from mitochondrion	oligopeptide-transporting ATPase activity	mitochondrion|integral to membrane|mitochondrial inner membrane
YOR213C	YOR213C	SAS5	hom	Verified	1.88868412914881	0.0294670832447026	no	250	0.037904886048399	251	NA	FT	CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS|CHROMOSOME	HISTONE ACETYLTRANSFERASE	Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; stimulates Sas2p HAT activity	chromatin silencing at telomere	acetyltransferase activity|histone acetyltransferase activity	nuclear chromatin|SAS acetyltransferase complex|nuclear chromosome, telomeric region
YGR225W	YGR225W	AMA1	hom	Verified	1.88582071082368	0.0296595595202604	no	251	0.0260812739296844	152	NA	FT	CELL CYCLE|CELL WALL ORG/BIOGENESIS|CELL DIVISION	NUCLEUS	UBIQUITIN LIGASE COMPLEX	Activator of meiotic anaphase promoting complex (APC/C); Cdc20p family member; required for initiation of spore wall assembly; required for Clb1p degradation during meiosis	ascospore wall assembly|positive regulation of protein catabolic process|ascospore formation|meiosis I	enzyme activator activity	anaphase-promoting complex
YMR125W	YMR125W	STO1	hom	Verified	1.88427040736604	0.0297642040643229	no	252	0.0436655484453515	236	NA	FT	RNA PROCESSING|RNA LOCALIZATION	NUCLEUS		Large subunit of the nuclear mRNA cap-binding protein complex, interacts with Npl3p to carry nuclear poly(A)+ mRNA to cytoplasm; also involved in nuclear mRNA degradation and telomere maintenance; orthologous to mammalian CBP80	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|mRNA splicing, via spliceosome|response to osmotic stress	mRNA binding	commitment complex|nuclear cap binding complex|polysome
YBR293W	YBR293W	VBA2	hom	Verified	1.88198402414167	0.0299190923990292	no	253	0.0287881380080823	211	NA					Permease of basic amino acids in the vacuolar membrane	basic amino acid transport|transmembrane transport	basic amino acid transmembrane transporter activity|drug transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane
YDL093W	YDL093W	PMT5	hom	Verified	1.88171749634581	0.0299371914385231	no	254	0.0324594725201322	139	NA	FT	CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt3p, can instead interact with Pmt2p in some conditions; target for new antifungals	protein O-linked mannosylation	dolichyl-phosphate-mannose-protein mannosyltransferase activity	integral to membrane|dolichyl-phosphate-mannose-protein mannosyltransferase complex
YDR175C	YDR175C	RSM24	hom	Verified	1.87976622482185	0.030069972736529	no	255	0.0374808365533254	183	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the small subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YDL079C	YDL079C	MRK1	hom	Verified	1.87487990494572	0.0304046235869269	no	256	0.0236454197866002	160	NA	FT	PROTEIN PHOSPHORYLATION			Glycogen synthase kinase 3 (GSK-3) homolog; one of four GSK-3 homologs in S. cerevisiae that function to activate Msn2p-dependent transcription of stress responsive genes and that function in protein degradation	regulation of protein catabolic process|protein phosphorylation|response to stress	protein serine/threonine kinase activity	cellular_component
YPL108W_p	YPL108W	YPL108W	hom	Uncharacterized	1.87214421867553	0.0305933269230024	no	257	0.0378158321635858	195	NA					Cytoplasmic protein of unknown function; non-essential gene that is induced in a GDH1 deleted strain with altered redox metabolism; GFP-fusion protein is induced in response to the DNA-damaging agent MMS	biological_process	molecular_function	cytoplasm
YJR003C_p	YJR003C	YJR003C	hom	Uncharacterized	1.86786285380987	0.0308905948646778	no	258	0.0317763249562603	149	NA	FT		MITOCHONDRION		Putative protein of unknown function; detected in highly purified mitochondria in high-throughput studies; predicted to be involved in ribosome biogenesis	biological_process	molecular_function	mitochondrion
YNL322C	YNL322C	KRE1	hom	Verified	1.86598763409737	0.0310215478030042	no	259	0.0349837049896728	230	NA	FT	CELL WALL ORG/BIOGENESIS	PLASMA MEMBRANE		Cell wall glycoprotein involved in beta-glucan assembly; serves as a K1 killer toxin membrane receptor	fungal-type cell wall organization	structural constituent of cell wall	fungal-type cell wall|integral to membrane
YMR304C-A_d	YMR304C-A	YMR304C-A	hom	Dubious	1.8639526147465	0.0311641794937839	no	260	0.0267717315635108	159	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene SCW10	Unknown	Unknown	Unknown
YJL088W	YJL088W	ARG3	hom	Verified	1.86264511946471	0.0312561059525498	no	261	0.0377995410617963	261	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Ornithine carbamoyltransferase (carbamoylphosphate:L-ornithine carbamoyltransferase), catalyzes the sixth step in the biosynthesis of the arginine precursor ornithine	arginine biosynthetic process|ornithine metabolic process	ornithine carbamoyltransferase activity	cytosol
YNR025C_d	YNR025C	YNR025C	hom	Dubious	1.85731432872937	0.031633223506762	no	262	0.0261569797119474	183	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion reduces expression of PIS1 gene encoding phosphatidylinositol synthase	Unknown	Unknown	Unknown
YBR181C	YBR181C	RPS6B	hom	Verified	1.85565068992437	0.0317516817627924	no	263	0.0306554297765749	165	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S6, no bacterial homolog; RPS6B has a paralog, RPS6A, that arose from the whole genome duplication	cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome	small-subunit processome|cytosolic small ribosomal subunit|cytoplasm
YBR077C	YBR077C	SLM4	hom	Verified	1.85316930910255	0.0319290475751934	no	264	0.0483923656311495	258	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|SIGNALING			Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; gene exhibits synthetic genetic interaction with MSS4	signal transduction|microautophagy	phosphatidylinositol-3,4-bisphosphate binding	fungal-type vacuole membrane|EGO complex|late endosome membrane|cytoplasm
YML082W_p	YML082W	YML082W	hom	Uncharacterized	1.85194878670707	0.032016588670509	no	265	0.0484039001965064	183	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Putative protein predicted to have carbon-sulfur lyase activity; transcriptionally regulated by Upc2p via an upstream sterol response element; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and the cytoplasm; YML082W is not an essential gene	sulfur compound metabolic process	carbon-sulfur lyase activity	nucleus|cytoplasm
YJL052W	YJL052W	TDH1	hom	Verified	1.84350827403699	0.0326274173953754	no	266	0.0610386795434905	259	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Glyceraldehyde-3-phosphate dehydrogenase, isozyme 1; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; protein abundance increases in response to DNA replication stress	gluconeogenesis|glycolysis	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity	mitochondrion|fungal-type cell wall|lipid particle|plasma membrane|cytoplasm
YNL233W	YNL233W	BNI4	hom	Verified	1.83914038006934	0.0329472705410514	no	267	0.0514316292080955	235	NA	FT	PROTEIN LOCALIZATION|CELL DIVISION|CARBOHYDRATE METABOLISM	SITE OF POLARIZED GROWTH|CYTOSKELETON		Targeting subunit for Glc7p protein phosphatase, localized to the bud neck, required for localization of chitin synthase III to the bud neck via interaction with the chitin synthase III regulatory subunit Skt5p	asymmetric protein localization|barrier septum assembly|chitin biosynthetic process	protein binding	incipient cellular bud site|cellular bud neck septin collar|cellular bud neck|septin ring
YNL067W-B_p	YNL067W-B	YNL067W-B	hom	Uncharacterized	1.83600620209472	0.0331783696933454	no	268	0.0419594640372289	171	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YJR110W	YJR110W	YMR1	hom	Verified	1.83593628750064	0.0331835400448425	no	269	0.0332461087236239	151	NA	FT	LIPID METABOLISM			Phosphatidylinositol 3-phosphate (PI3P) phosphatase; involved in various protein sorting pathways, including CVT targeting and endosome to vacuole transport; has similarity to the conserved myotubularin dual specificity phosphatase family	phosphatidylinositol dephosphorylation	mRNA binding|phosphatidylinositol-3-phosphatase activity	cytoplasm
YNL024C_p	YNL024C	YNL024C	hom	Uncharacterized	1.83285798141153	0.0334118469344017	no	270	0.0338931694274504	164	NA					Putative methyltransferase; has seven beta-strand methyltransferase motif; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; despite similarity to methyltransferases, null mutant does not display alterations in lysine methylation pattern	biological_process	S-adenosylmethionine-dependent methyltransferase activity	cytoplasm
YDR270W	YDR270W	CCC2	hom	Verified	1.82701028588747	0.0338491114371959	no	271	0.050829394623278	279	NA	FF|FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Cu(+2)-transporting P-type ATPase; required for export of copper from the cytosol into an extracytosolic compartment; has similarity to human proteins involved in Menkes and Wilsons diseases; protein abundance increases in response to DNA replication stress; affects TBSV model (+)RNA virus replication by regulating copper metabolism	cellular iron ion homeostasis|copper ion export|transmembrane transport	copper ion binding|cation-transporting ATPase activity	integral to membrane|trans-Golgi network transport vesicle membrane
YCL064C	YCL064C	CHA1	hom	Verified	1.82690098437636	0.0338573291197533	no	272	0.0335053907348013	177	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		Catabolic L-serine (L-threonine) deaminase, catalyzes the degradation of both L-serine and L-threonine; required to use serine or threonine as the sole nitrogen source, transcriptionally induced by serine and threonine	threonine catabolic process|L-serine catabolic process	L-threonine ammonia-lyase activity|L-serine ammonia-lyase activity	mitochondrial nucleoid|mitochondrion
YDR535C_d	YDR535C	YDR535C	hom	Dubious	1.82586336057747	0.0339354231971844	no	273	0.0458826282495839	241	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YDR535C is not an essential gene.	Unknown	Unknown	Unknown
YNL296W_d	YNL296W	YNL296W	hom	Dubious	1.82422847659097	0.0340587690903731	no	274	0.0451833079697531	234	NA					Dubious open reading frame unlikely to encode a functional protein; deletion adversely affects sporulation; deletion mutant exhibits synthetic phenotype under expression of mutant huntingtin fragment, but gene does not have human ortholog	Unknown	Unknown	Unknown
YPR084W_p	YPR084W	YPR084W	hom	Uncharacterized	1.82085338787843	0.0343145731430208	no	275	0.0323979056489078	180	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YGL157W	YGL157W	ARI1	hom	Verified	1.81952080489988	0.0344160058437888	no	276	0.0249345104169463	155	NA	FT	OXIDATION-REDUCTION PROCESS	NUCLEUS		NADPH-dependent aldehyde reductase, utilizes aromatic and alophatic aldehyde substrates; member of the short-chain dehydrogenase/reductase superfamily	biological_process	oxidoreductase activity|carbonyl reductase (NADPH) activity	nucleus|cytoplasm
YLR210W	YLR210W	CLB4	hom	Verified	1.81885407266388	0.0344668481374655	no	277	0.0343912916717958	144	NA	FT	CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION	NUCLEUS|CYTOSKELETON		B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation	G2/M transition of mitotic cell cycle|S phase of mitotic cell cycle|regulation of cyclin-dependent protein kinase activity|positive regulation of spindle pole body separation	cyclin-dependent protein kinase regulator activity	nucleus|spindle pole body|cytoplasm
YMR150C	YMR150C	IMP1	hom	Verified	1.81884232814759	0.0344677442793835	no	278	0.0254328897854387	121	NA	FT	PROTEIN LOCALIZATION|PROTEOLYSIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p	protein processing involved in protein targeting to mitochondrion	endopeptidase activity	mitochondrion|mitochondrial inner membrane peptidase complex
YOR384W	YOR384W	FRE5	hom	Verified	1.81340866210374	0.0348844072697451	no	279	0.0467593031026281	231	NA	FT	ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION|PLASMA MEMBRANE		Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	ferric-chelate reductase activity	mitochondrion|integral to membrane
YDL047W	YDL047W	SIT4	hom	Verified	1.81333842044662	0.0348898204740391	no	280	0.0355000606420143	201	NA	FT	CELL CYCLE|RNA PROCESSING|SIGNALING|RESPONSE TO DNA DAMAGE|CELL WALL ORG/BIOGENESIS|CELL DIVISION|CYTOSKELETON ORGANIZATION|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		Type 2A-related serine-threonine phosphatase that functions in the G1/S transition of the mitotic cycle; cytoplasmic and nuclear protein that modulates functions mediated by Pkc1p including cell wall and actin cytoskeleton organization	intracellular protein kinase cascade|replicative cell aging|G1/S transition of mitotic cell cycle|actin cytoskeleton organization|DNA repair|cellular response to oxidative stress|fungal-type cell wall organization|TOR signaling cascade|dephosphorylation|tRNA wobble uridine modification	protein serine/threonine phosphatase activity	nucleus|cytoplasm
YDR178W	YDR178W	SDH4	hom	Verified	1.80762835402236	0.0353321811017253	no	281	0.0501929166877783	232	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Membrane anchor subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain	mitochondrial electron transport, succinate to ubiquinone|cellular respiration|tricarboxylic acid cycle	succinate dehydrogenase (ubiquinone) activity	mitochondrial respiratory chain complex II|mitochondrion
YGR222W	YGR222W	PET54	hom	Verified	1.80255535063615	0.0357290372610022	no	282	0.0441294426504419	246	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial inner membrane protein; binds to the 5' UTR of the COX3 mRNA to activate its translation together with Pet122p and Pet494p; also binds to the COX1 Group I intron AI5 beta to facilitate exon ligation during splicing	Group I intron splicing|positive regulation of mitochondrial translation|mitochondrial respiratory chain complex IV biogenesis	translation regulator activity|RNA binding	mitochondrion|extrinsic to mitochondrial inner membrane|mitochondrial inner membrane|mitochondrial matrix
YJL115W	YJL115W	ASF1	hom	Verified	1.80030736632636	0.0359060592048148	no	283	0.0343971447275546	145	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS		Nucleosome assembly factor, involved in chromatin assembly and disassembly, anti-silencing protein that causes derepression of silent loci when overexpressed; plays a role in regulating Ty1 transposition	DNA replication-independent nucleosome assembly|histone acetylation|nucleosome disassembly|histone exchange|positive regulation of histone acetylation|chromatin silencing at silent mating-type cassette|chromatin silencing at telomere|DNA replication-dependent nucleosome assembly|regulation of transcription from RNA polymerase II promoter in response to stress	histone binding	chromatin assembly complex
YNR063W_p	YNR063W	YNR063W	hom	Uncharacterized	1.79784374612895	0.0361008863588722	no	284	0.0274430266721588	164	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Putative zinc-cluster protein of unknown function	biological_process	sequence-specific DNA binding	cellular_component
YEL013W	YEL013W	VAC8	hom	Verified	1.79779136019536	0.0361050385060894	no	285	0.0281283221537839	200	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS			Phosphorylated and palmitoylated vacuolar membrane protein that interacts with Atg13p, required for the cytoplasm-to-vacuole targeting (Cvt) pathway; interacts with Nvj1p to form nucleus-vacuole junctions	piecemeal microautophagy of nucleus|vacuole inheritance|CVT vesicle assembly|vacuole fusion, non-autophagic|macroautophagy|nucleus-vacuole junction assembly	protein anchor	fungal-type vacuole membrane|nucleus-vacuole junction|Myo2p-Vac17p-Vac8p transport complex
YBR208C	YBR208C	DUR1,2	hom	Verified	1.79750424489413	0.0361278024196829	no	286	0.0275268392934671	184	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Urea amidolyase; contains both urea carboxylase and allophanate hydrolase activities, degrades urea to CO2 and NH3; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation; protein abundance increases in response to DNA replication stress	allantoin catabolic process|urea catabolic process	urea carboxylase activity|allophanate hydrolase activity	cytoplasm
YPR038W_d	YPR038W	IRC16	hom	Dubious	1.79637486997528	0.0362174588826192	no	287	0.0322446258267045	214	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene YPR037C; null mutant displays increased levels of spontaneous Rad52p foci	Unknown	Unknown	Unknown
YJL053W	YJL053W	PEP8	hom	Verified	1.79519334969506	0.0363114498393763	no	288	0.0443798271213225	262	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM		Vacuolar protein component of the retromer; forms part of the multimeric membrane-associated retromer complex involved in vacuolar protein sorting along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport; interacts with Ypt7p; protein abundance increases in response to DNA replication stress	protein retention in Golgi apparatus|retrograde transport, endosome to Golgi	protein transporter activity	endosome|retromer complex, inner shell|retromer complex
YDL044C	YDL044C	MTF2	hom	Verified	1.79487393212298	0.0363368940399164	no	289	0.0458428093438689	261	NA	FT	RNA PROCESSING|TRANSLATION	MITOCHONDRION		Mitochondrial matrix protein that interacts with an N-terminal region of mitochondrial RNA polymerase (Rpo41p) and couples RNA processing and translation to transcription	cytoplasmic translation|mRNA processing	RNA binding	mitochondrion
YJR113C	YJR113C	RSM7	hom	Verified	1.79282787927764	0.0365002250849779	no	290	0.0578035263535014	285	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S7 ribosomal protein	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YLR404W	YLR404W	FLD1	hom	Verified	1.78931247723505	0.0367822528683839	no	291	0.0388085441622631	174	NA	FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Seipin protein involved in lipid droplet morphology, number, and size; proposed to be involved in lipid metabolism; related to the human BSCL2 which is associated with lipodystrophy	lipid particle organization	molecular_function	integral to membrane|endoplasmic reticulum|cortical endoplasmic reticulum
YML022W	YML022W	APT1	hom	Verified	1.78617715331529	0.0370352895273729	no	292	0.01862787128714	117	NA	FT	NUCLEOTIDE METABOLISM	NUCLEUS		Adenine phosphoribosyltransferase; catalyzes the formation of AMP from adenine and 5-phosphoribosylpyrophosphate; involved in the salvage pathway of purine nucleotide biosynthesis; APT1 has a paralog, APT2, that arose from the whole genome duplication	AMP biosynthetic process|adenine salvage	adenine phosphoribosyltransferase activity	nucleus|cytoplasm
YOR313C	YOR313C	SPS4	hom	Verified	1.78540068066781	0.0370981741657116	no	293	0.0353530307055214	210	NA	FT	CELL CYCLE			Protein whose expression is induced during sporulation; not required for sporulation; heterologous expression in E. coli induces the SOS response that senses DNA damage	ascospore formation	molecular_function	cellular_component
YOR158W	YOR158W	PET123	hom	Verified	1.78200383476945	0.0373743031929975	no	294	0.0447226315354319	266	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the small subunit; PET123 exhibits genetic interactions with PET122, which encodes a COX3 mRNA-specific translational activator	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YNL090W	YNL090W	RHO2	hom	Verified	1.78136919220719	0.0374260788467217	no	295	0.0390707734402746	238	NA	FT	SIGNALING|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION	PLASMA MEMBRANE		Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, involved in the establishment of cell polarity and in microtubule assembly	microtubule-based process|fungal-type cell wall organization|actin filament organization|establishment of cell polarity|small GTPase mediated signal transduction	GTPase activity	membrane
YJR091C	YJR091C	JSN1	hom	Verified	1.78032837412834	0.0375111180757277	no	296	0.0215228574569701	131	NA	FT	PROTEIN LOCALIZATION	MITOCHONDRION		Member of the Puf family of RNA-binding proteins, interacts with mRNAs encoding membrane-associated proteins; involved in localizing the Arp2/3 complex to mitochondria; overexpression causes increased sensitivity to benomyl	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|cellular protein complex localization|establishment of mitochondrion localization	mRNA binding	external side of mitochondrial outer membrane
YLR388W	YLR388W	RPS29A	hom	Verified	1.77905955069626	0.0376149996592948	no	297	0.0702129040243281	283	NA	FT	TRANSLATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S29 and bacterial S14; RPS29A has a paralog, RPS29B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic small ribosomal subunit
YIL074C	YIL074C	SER33	hom	Verified	1.77628260067824	0.0378431747835095	no	298	0.0410778561932988	222	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS			3-phosphoglycerate dehydrogenase; catalyzes the first step in serine and glycine biosynthesis; SER33 has a paralog, SER3, that arose from the whole genome duplication	serine family amino acid biosynthetic process	phosphoglycerate dehydrogenase activity	cytoplasm
YLR418C	YLR418C	CDC73	hom	Verified	1.77614598364286	0.0378544293562507	no	299	0.102944738414801	448	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION	NUCLEUS|CHROMOSOME	RNA POL II, HOLOENZYME	Component of the Paf1p complex; binds to and modulates the activity of RNA polymerases I and II; required for expression of certain genes, modification of some histones, and telomere maintenance; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay; protein abundance increases in response to DNA replication stress	transcription elongation from RNA polymerase I promoter|negative regulation of DNA recombination|mRNA 3'-end processing|recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex|positive regulation of transcription elongation from RNA polymerase II promoter|Unknown|regulation of transcription-coupled nucleotide-excision repair|transcription elongation from RNA polymerase II promoter	chromatin binding|TFIIF-class binding transcription factor activity|RNA polymerase II core binding|RNA polymerase II transcription factor binding transcription factor activity	nucleus|transcriptionally active chromatin|Cdc73/Paf1 complex
YCR087C-A_p	YCR087C-A	YCR087C-A	hom	Uncharacterized	1.77367083700076	0.0380588064948638	no	300	0.0454215834095249	250	NA	FT		NUCLEUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; YCR087C-A is not an essential gene	biological_process	molecular_function	nucleolus
YDR059C	YDR059C	UBC5	hom	Verified	1.77085446471222	0.0382924530758143	no	301	0.036671651585742	157	NA					Ubiquitin-conjugating enzyme; mediates selective degradation of short-lived, abnormal, or excess proteins, including histone H3; central component of the cellular stress response; expression is heat inducible; protein abundance increases in response to DNA replication stress; UBC5 has a paralog, UBC4, that arose from the whole genome duplication	protein polyubiquitination|response to stress	ubiquitin-protein ligase activity	proteasome complex
YMR056C	YMR056C	AAC1	hom	Verified	1.76900705917504	0.0384463482741512	no	302	0.0325497165469779	206	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Mitochondrial inner membrane ADP/ATP translocator; exchanges cytosolic ADP for mitochondrially synthesized ATP; phosphorylated; Aac1p is a minor isoform while Pet9p is the major ADP/ATP translocator; relocalizes from mitochondrion to cytoplasm upon DNA replication stress	heme biosynthetic process|mitochondrial transport|heme transport|aerobic respiration	ATP:ADP antiporter activity	mitochondrion|integral to membrane|mitochondrial inner membrane
YGL124C	YGL124C	MON1	hom	Verified	1.76620349923979	0.038680857104924	no	303	0.0491791521019269	268	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT			Protein required for fusion of cvt-vesicles and autophagosomes with the vacuole; associates, as a complex with Ccz1p, with a perivacuolar compartment; potential Cdc28p substrate	autophagy|vesicle docking|protein targeting to vacuole	molecular_function	cytosol|fungal-type vacuole membrane|Mon1-Ccz1 complex
YLR319C	YLR319C	BUD6	hom	Verified	1.76611455112785	0.0386883163618698	no	304	0.0459087511088339	150	NA	FT	CELL CYCLE|CHROMATIN ORGANIZATION|SIGNALING|CELL DIVISION|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Actin- and formin-interacting protein; stimulates actin cable nucleation by recruiting actin monomers to Bni1p; involved in polarized cell growth; isolated as bipolar budding mutant; potential Cdc28p substrate	bipolar cellular bud site selection|positive regulation of formin-nucleated actin cable assembly|cellular bud site selection|Rho protein signal transduction|extrachromosomal circular DNA localization involved in cell aging|establishment of cell polarity|response to osmotic stress|cytokinesis	cytoskeletal regulatory protein binding	polarisome|actin cap|spindle pole body|mating projection tip
YDL122W	YDL122W	UBP1	hom	Verified	1.76449143027466	0.0388246384529144	no	305	0.0351159668676019	191	NA	FT	PROTEOLYSIS	ENDOPLASMIC RETICULUM		Ubiquitin-specific protease that removes ubiquitin from ubiquitinated proteins; cleaves at the C terminus of ubiquitin fusions irrespective of their size; capable of cleaving polyubiquitin chains	protein deubiquitination	ubiquitin-specific protease activity	endoplasmic reticulum|cytoplasm
YPL187W	YPL187W	MF(ALPHA)1	hom	Verified	1.76365081539143	0.038895393345952	no	306	0.0400002051387677	174	NA	FT	SIGNALING			Mating pheromone alpha-factor, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)2, although MF(ALPHA)1 produces most alpha-factor	pheromone-dependent signal transduction involved in conjugation with cellular fusion	mating pheromone activity	extracellular region
YIL168W	YIL168W	YIL168W	hom	pseudogene	1.76327296244592	0.0389272315721445	no	307	0.0385389894385994	179	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Open reading frame, unlikely to produce a functional protein in S288C; in closely related species and other <i>S. cerevisiae</i> strain backgrounds YIL168W and adjacent ORF, YIL167W, constitute a single ORF encoding L-serine dehydratase	serine family amino acid metabolic process	L-serine ammonia-lyase activity	cellular_component
YGL149W_d	YGL149W	YGL149W	hom	Dubious	1.75977837358656	0.0392226956330863	no	308	0.0339914935097147	161	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF INO80/YGL150C.	Unknown	Unknown	Unknown
YGL192W	YGL192W	IME4	hom	Verified	1.75956059187466	0.0392411691163412	no	309	0.0551481178010559	256	NA	FT	CELL CYCLE	NUCLEUS		Probable mRNA N6-adenosine methyltransferase required for entry into meiosis; transcribed in diploid cells; haploids repress IME4 transcription via production of antisense IME4 transcripts; antisense transcription is repressed in diploids	meiosis|mRNA methylation	mRNA (N6-adenosine)-methyltransferase activity	cellular_component
YDL194W	YDL194W	SNF3	hom	Verified	1.75753325240048	0.0394134795669152	no	310	0.0341068817349519	190	NA	FT	CELL CYCLE|SIGNALING	PLASMA MEMBRANE		Plasma membrane low glucose sensor, regulates glucose transport; contains 12 predicted transmembrane segments and a long C-terminal tail required for induction of hexose transporters; also senses fructose and mannose; SNF3 has a paralog, RGT2, that arose from the whole genome duplication	mannose transport|glucose transport|signal transduction|negative regulation of meiosis|detection of glucose|fructose transport	glucose transmembrane transporter activity|receptor activity|glucose binding	integral to membrane|plasma membrane
YPL017C	YPL017C	IRC15	hom	Verified	1.75553048735725	0.0395843052666263	no	311	0.0603532692857835	291	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|OXIDATION-REDUCTION PROCESS|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION	CYTOSKELETON		Microtubule associated protein; regulates microtubule dynamics; required for accurate meiotic chromosome segregation; null mutant displays large budded cells due to delayed mitotic progression, increased levels of spontaneous Rad52 foci	microtubule nucleation|mitotic recombination|microtubule anchoring|meiotic sister chromatid segregation|attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation|positive regulation of mitotic cell cycle	microtubule binding|S-adenosylmethionine-dependent methyltransferase activity	microtubule|cytoplasm
YML071C	YML071C	COG8	hom	Verified	1.74740578959145	0.0402834869602462	no	312	0.181858945776531	687	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments	intra-Golgi vesicle-mediated transport|CVT pathway	molecular_function	Golgi transport complex
YKR010C	YKR010C	TOF2	hom	Verified	1.74731228960798	0.0402915912289261	no	313	0.0291427324923926	166	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|CHROMOSOME SEGREGATION|GENE SILENCING	NUCLEUS|MITOCHONDRION		Protein required for rDNA silencing and mitotic rDNA condensation; stimulates Cdc14p phosphatase activity and biphasic release to promote rDNA repeat segregation; required for condensin recruitment to the replication fork barrier site; TOF2 has a paralog, NET1, that arose from the whole genome duplication	nucleolus organization|rDNA condensation|chromatin silencing at rDNA|protein localization to nucleolar rDNA repeats	phosphatase activator activity	mitochondrion|nucleolus
YGL257C	YGL257C	MNT2	hom	Verified	1.74721828308379	0.0402997407377897	no	314	0.0385005353949335	145	NA	FT	CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Mannosyltransferase involved in adding the 4th and 5th mannose residues of O-linked glycans	protein O-linked glycosylation	alpha-1,3-mannosyltransferase activity	cellular_component
YBL028C	YBL028C	YBL028C	hom	Verified	1.73804876474055	0.0411011108006954	no	315	0.0549032008876458	169	NA	FT		NUCLEUS		Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis	biological_process	molecular_function	ribosome|nucleolus|nucleus|preribosome, large subunit precursor
YKR009C	YKR009C	FOX2	hom	Verified	1.7343117424226	0.0414313925592816	no	316	0.0217943995548036	131	NA	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS			Multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway; has 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities	fatty acid beta-oxidation	enoyl-CoA hydratase activity|3-hydroxyacyl-CoA dehydrogenase activity	peroxisome
YNR036C	YNR036C	MRPS12	hom	Verified	1.73419390042576	0.0414418424316105	no	317	0.0495912162720247	275	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial protein; may interact with ribosomes based on co-purification experiments; similar to E. coli and human mitochondrial S12 ribosomal proteins	mitochondrial translation	structural constituent of ribosome	mitochondrion|ribosome|mitochondrial small ribosomal subunit
YOL087C	YOL087C	DUF1	hom	Verified	1.73292015239142	0.0415549309275117	no	318	0.0858362659543967	331	NA					Ubiquitin-binding protein of unknown function; contains one WD40 repeat in a beta-propeller fold; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; homolog of human WDR48/UAF1, which is involved in regulating the Fanconi anemia pathway; deletion mutant is sensitive to various chemicals including phenanthroline, sanguinarine, and nordihydroguaiaretic acid	biological_process	ubiquitin binding	cytoplasm
YDR516C	YDR516C	EMI2	hom	Verified	1.73085600503418	0.0417387250407312	no	319	0.042705493423312	199	NA	FT	TRANSCRIPTION FROM RNA POL II|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY			Non-essential protein of unknown function; required for transcriptional induction of the early meiotic-specific transcription factor IME1; required for sporulation; expression regulated by glucose-repression transcription factors Mig1/2p; EMI2 has a paralog, GLK1, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress	ascospore formation|positive regulation of transcription from RNA polymerase II promoter	molecular_function	cytoplasm
YGL165C_d	YGL165C	YGL165C	hom	Dubious	1.73041824224913	0.0417777884511081	no	320	0.0314787064584008	146	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CUP2/YGL166W	Unknown	Unknown	Unknown
YJR117W	YJR117W	STE24	hom	Verified	1.72609416807589	0.0421652364300221	no	321	0.0307934793705828	160	NA	FT	PROTEOLYSIS	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|MITOCHONDRION		Highly conserved zinc metalloprotease that functions in two steps of a-factor maturation, C-terminal CAAX proteolysis and the first step of N-terminal proteolytic processing; contains multiple transmembrane spans	CAAX-box protein processing|peptide pheromone maturation	metalloendopeptidase activity	mitochondrial outer membrane|integral to endoplasmic reticulum membrane|integral to membrane|nuclear inner membrane
YBR279W	YBR279W	PAF1	hom	Verified	1.72416147342495	0.0423393485180194	no	322	0.0795471851318762	370	NA	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|RIBOSOME BIOGENESIS|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION|GENE SILENCING	NUCLEUS|CHROMOSOME	RNA POL II, HOLOENZYME	Component of the Paf1p complex involved in transcription elongation; binds to and modulates the activity of RNA polymerases I and II; required for expression of a subset of genes, including cell cycle-regulated genes; involved in SER3 repression by helping to maintain SRG1 transcription-dependent nucleosome occupancy; homolog of human PD2/hPAF1	negative regulation of DNA recombination|mRNA 3'-end processing|snoRNA transcription from an RNA polymerase II promoter|regulation of transcription by chromatin organization|transcription from RNA polymerase I promoter|regulation of transcription-coupled nucleotide-excision repair|rRNA processing|transcription elongation from RNA polymerase I promoter|regulation of chromatin silencing at telomere|regulation of transcription from RNA polymerase II promoter|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of histone H3-K4 methylation|negative regulation of transcription from RNA polymerase II promoter|global genome nucleotide-excision repair|chromatin silencing at rDNA|Unknown|snoRNA 3'-end processing|transcription elongation from RNA polymerase II promoter|regulation of transcription involved in G1 phase of mitotic cell cycle	RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity|chromatin binding|TFIIF-class binding transcription factor activity|RNA polymerase II core binding|RNA polymerase II transcription factor binding transcription factor activity	transcriptionally active chromatin|nucleus|Cdc73/Paf1 complex
YJL064W_d	YJL064W	YJL064W	hom	Dubious	1.72309560539956	0.0424356187046721	no	323	0.0386165307623125	220	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene YJL065C/DLS1	Unknown	Unknown	Unknown
YAL060W	YAL060W	BDH1	hom	Verified	1.71988739260169	0.0427264563287564	no	324	0.0482944355454009	185	NA	FT	OXIDATION-REDUCTION PROCESS			NAD-dependent (R,R)-butanediol dehydrogenase, catalyzes oxidation of (R,R)-2,3-butanediol to (3R)-acetoin, oxidation of meso-butanediol to (3S)-acetoin, and reduction of acetoin; enhances use of 2,3-butanediol as an aerobic carbon source	alcohol metabolic process|butanediol biosynthetic process	(R,R)-butanediol dehydrogenase activity	cytoplasm
YPL173W	YPL173W	MRPL40	hom	Verified	1.716787305908	0.0430090205853215	no	325	0.0520904851108134	295	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YOR070C	YOR070C	GYP1	hom	Verified	1.71482628704795	0.0431885402475103	no	326	0.124372946154697	575	NA	FF|FT	VESICLE-MEDIATED TRANSPORT|SIGNALING|NUCLEOTIDE METABOLISM	MITOCHONDRION|GOLGI APPARATUS		Cis-golgi GTPase-activating protein (GAP) for the Rab family members Ypt1p (in vivo) and for Ypt1p, Sec4p, Ypt7p, and Ypt51p (in vitro); involved in vesicle docking and fusion	vesicle-mediated transport	Rab GTPase activator activity	mitochondrion|Golgi apparatus
YOR283W	YOR283W	YOR283W	hom	Verified	1.71476730387743	0.0431939491683615	no	327	0.0412034272396718	185	NA	FT	CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS		Phosphatase with a broad substrate specificity and some similarity to GPM1/YKL152C, a phosphoglycerate mutase; YOR283W is not an essential gene	dephosphorylation	phosphatase activity	nucleus|cytoplasm
YBR133C	YBR133C	HSL7	hom	Verified	1.71129841458884	0.043513019444617	no	328	0.0585829575170658	299	NA	FT	CELL CYCLE|CHROMATIN ORGANIZATION|CELL DIVISION	SITE OF POLARIZED GROWTH		Protein arginine N-methyltransferase; exhibits septin and Hsl1p-dependent bud neck localization and periodic Hsl1p-dependent phosphorylation; required along with Hsl1p for bud neck recruitment, phosphorylation, and degradation of Swe1p; relocalizes away from bud neck upon DNA replication stress	G2/M transition of mitotic cell cycle|regulation of cell cycle	protein-arginine omega-N symmetric methyltransferase activity|protein-arginine omega-N monomethyltransferase activity	cellular bud neck
YKR043C	YKR043C	SHB17	hom	Verified	1.71129239955376	0.0435135743585039	no	329	0.0694100791599591	290	NA	FT	CARBOHYDRATE METABOLISM	NUCLEUS		Sedoheptulose bisphosphatase involved in riboneogenesis; dephosphorylates sedoheptulose 1,7-bisphosphate, which is converted via the nonoxidative pentose phosphate pathway to ribose-5-phosphate; facilitates the conversion of glycolytic intermediates to pentose phosphate units; also has fructose 1,6-bisphosphatase activity but this is probably not biologically relevant, since deletion does not affect FBP levels; GFP-fusion protein localizes to the cytoplasm and nucleus	ribose phosphate biosynthetic process	sedoheptulose-bisphosphatase activity	nucleus|cytoplasm
YMR153W	YMR153W	NUP53	hom	Verified	1.70802365691994	0.0438159764953015	no	330	0.0369273396759433	211	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|CELL DIVISION|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	FG-nucleoporin component of central core of nuclear pore complex (NPC); also part of the NPC nuclear basket; contributes directly to nucleocytoplasmic transport; involved in regulation of transcription and mitosis; induces membrane tubulation, which may contribute to nuclear pore assembly; NUP53 has a paralog, ASM4, that arose from the whole genome duplication	positive regulation of transcription, DNA-dependent|NLS-bearing substrate import into nucleus|regulation of protein desumoylation|nuclear pore organization|protein import into nucleus|regulation of mitosis|mitotic cell cycle spindle assembly checkpoint	nucleocytoplasmic transporter activity|phospholipid binding|single-stranded DNA binding	nuclear pore central transport channel|nuclear pore nuclear basket|integral to membrane|nuclear pore
YLR374C_d	YLR374C	YLR374C	hom	Dubious	1.70360249286388	0.0442276877232152	no	331	0.0812878349021265	321	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF STP3/YLR375W	Unknown	Unknown	Unknown
YCL036W	YCL036W	GFD2	hom	Verified	1.70172674107207	0.0444033025583092	no	332	0.0439766297240045	218	NA					Protein of unknown function; identified as a high-copy suppressor of a dbp5 mutation; GFD2 has a paralog, YDR514C, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YDR051C	YDR051C	DET1	hom	Verified	1.69116171720858	0.0454029602160297	no	333	0.0354790055316446	134	NA	FT		NUCLEUS		Acid phosphatase involved in the non-vesicular transport of sterols in both directions between the endoplasmic reticulum and plasma membrane; deletion confers sensitivity to nickel	intracellular sterol transport|dephosphorylation	acid phosphatase activity	nucleus|cytoplasm
YLL018C-A	YLL018C-A	COX19	hom	Verified	1.69071777811192	0.0454453586001143	no	334	0.0582605711630154	229	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS	MITOCHONDRION		Protein required for cytochrome c oxidase assembly, located in the cytosol and mitochondrial intermembrane space; putative copper metallochaperone that delivers copper to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs	mitochondrial respiratory chain complex IV assembly|metal ion transport	copper ion binding|copper chaperone activity	cytosol|mitochondrial intermembrane space
YNL250W	YNL250W	RAD50	hom	Verified	1.68581529275477	0.0459156906543408	no	335	0.029622042314588	189	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS|MITOCHONDRION		Subunit of MRX complex with Mre11p and Xrs2p; complex is involved in processing double-strand DNA breaks in vegetative cells, initiation of meiotic DSBs, telomere maintenance, and nonhomologous end joining; forms nuclear foci upon DNA replication stress	base-excision repair|meiotic DNA double-strand break processing|telomere maintenance via recombination|meiosis|meiotic DNA double-strand break formation|double-strand break repair via nonhomologous end joining|telomere maintenance|double-strand break repair via break-induced replication|negative regulation of endodeoxyribonuclease activity	double-stranded DNA binding|single-stranded telomeric DNA binding|ATPase activity|double-stranded telomeric DNA binding|G-quadruplex DNA binding|telomeric DNA binding|adenylate kinase activity	mitochondrion|nucleus|Mre11 complex
YDL188C	YDL188C	PPH22	hom	Verified	1.68416012260466	0.0460753638152198	no	336	0.0458086621464968	206	NA	FT	CELL CYCLE|TRANSLATION|CELL DIVISION|CYTOSKELETON ORGANIZATION	NUCLEUS|CHROMOSOME		Catalytic subunit of protein phosphatase 2A (PP2A); functionally redundant with Pph21p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis; protein abundance increases in response to DNA replication stress; PPH22 has a paralog, PPH21, that arose from the whole genome duplication	actin filament organization|budding cell bud growth|G1/S transition of mitotic cell cycle|protein dephosphorylation|mitotic cell cycle spindle assembly checkpoint|regulation of translation	protein serine/threonine phosphatase activity	condensed nuclear chromosome, centromeric region
YIL085C	YIL085C	KTR7	hom	Verified	1.6841380455241	0.0460774965868957	no	337	0.0410949639246849	213	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	GOLGI APPARATUS		Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; KTR7 has a paralog, KTR5, that arose from the whole genome duplication	fungal-type cell wall organization|protein N-linked glycosylation	mannosyltransferase activity	Golgi apparatus
YGR268C	YGR268C	HUA1	hom	Verified	1.68330521923522	0.0461580102852475	no	338	0.0580730467125712	265	NA					Cytoplasmic protein containing a zinc finger domain with sequence similarity to that of Type I J-proteins; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin patch assembly	biological_process	molecular_function	cytoplasm
YNL052W	YNL052W	COX5A	hom	Verified	1.68319400976453	0.0461687700359082	no	339	0.0339895437948229	190	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Subunit Va of cytochrome c oxidase; cytochrome c oxidase is the terminal member of the mitochondrial inner membrane electron transport chain; Cox5Ap is predominantly expressed during aerobic growth while its isoform Vb (Cox5Bp) is expressed during anaerobic growth; COX5A has a paralog, COX5B, that arose from the whole genome duplication	mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity	mitochondrion|integral to membrane|mitochondrial respiratory chain complex IV
YGR012W	YGR012W	YGR012W	hom	Verified	1.68184223328153	0.0462997183781338	no	340	0.036573220412119	153	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		Putative cysteine synthase, localized to the mitochondrial outer membrane	cysteine biosynthetic process	cysteine synthase activity	mitochondrial outer membrane|mitochondrion
YKL215C	YKL215C	OXP1	hom	Verified	1.67667991716188	0.0468025449013784	no	341	0.0345383866455109	151	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			5-oxoprolinase; enzyme is ATP-dependent and functions as a dimer; similar to mouse Oplah gene; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress	glutathione metabolic process	5-oxoprolinase (ATP-hydrolyzing) activity	cytoplasm
YMR216C	YMR216C	SKY1	hom	Verified	1.67346335781678	0.0471180570827037	no	342	0.105169210328931	449	NA	FF|FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|ION HOMEOSTASIS|PROTEIN PHOSPHORYLATION|ION HOMEOSTASIS			SR protein kinase (SRPK) involved in regulating proteins involved in mRNA metabolism and cation homeostasis; similar to human SRPK1	cellular cation homeostasis|cellular ion homeostasis|response to drug|protein phosphorylation|positive regulation of protein import into nucleus|regulation of cell size|mRNA splice site selection	protein serine/threonine kinase activity|protein kinase activity	cytoplasm
YPR030W	YPR030W	CSR2	hom	Verified	1.66874850164356	0.0475836163012258	no	343	0.0570959723649767	225	NA	FT	VESICLE-MEDIATED TRANSPORT|TRANSCRIPTION FROM RNA POL II|MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS	NUCLEUS		Nuclear ubiquitin protein ligase binding protein; may regulate utilization of nonfermentable carbon sources and endocytosis of plasma membrane proteins; overproduction suppresses chs5 spa2 lethality at high temp; ubiquitinated by Rsp5p, deubiquitinated by Ubp2p; CSR2 has a paralog, ECM21, that arose from the whole genome duplication	fungal-type cell wall organization|regulation of transcription from RNA polymerase II promoter|ubiquitin-dependent endocytosis	ubiquitin protein ligase binding	nucleus
YKR101W	YKR101W	SIR1	hom	Verified	1.6671452299497	0.0477427651489017	no	344	0.0399652487164456	216	NA	FT	CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS|CHROMOSOME		Protein involved in repression of transcription at the silent mating-type loci HML and HMR; recruitment to silent chromatin requires interactions with Orc1p and with Sir4p, through a common Sir1p domain; binds to centromeric chromatin	establishment of chromatin silencing|chromatin silencing at silent mating-type cassette	chromatin binding|sequence-specific DNA binding	chromatin silencing complex
YIL094C	YIL094C	LYS12	hom	Verified	1.66546019900103	0.0479104889387996	no	345	0.047172041146629	260	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS	MITOCHONDRION		Homo-isocitrate dehydrogenase, an NAD-linked mitochondrial enzyme required for the fourth step in the biosynthesis of lysine, in which homo-isocitrate is oxidatively decarboxylated to alpha-ketoadipate	lysine biosynthetic process	homoisocitrate dehydrogenase activity	mitochondrion
YNL111C	YNL111C	CYB5	hom	Verified	1.65227369866489	0.0492393842266918	no	346	0.090926020821074	383	NA	FF|FT	LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Cytochrome b5, involved in the sterol and lipid biosynthesis pathways; acts as an electron donor to support sterol C5-6 desaturation	sterol biosynthetic process	electron carrier activity	endoplasmic reticulum membrane
YFR044C	YFR044C	DUG1	hom	Verified	1.6488729595555	0.0495868319483611	no	347	0.0533415523566171	272	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|PROTEOLYSIS	MITOCHONDRION		Cys-Gly metallo-di-peptidase; forms a complex with Dug2p and Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p)	glutathione catabolic process	metallodipeptidase activity|omega peptidase activity	mitochondrion|ribosome|cytoplasm
YOL061W	YOL061W	PRS5	hom	Verified	1.64763629658293	0.049713663748019	no	348	0.0517792101958471	208	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM			5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase; synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; forms cytoplasmic foci upon DNA replication stress	fungal-type cell wall organization|5-phosphoribose 1-diphosphate biosynthetic process	ribose phosphate diphosphokinase activity	cytoplasm
YCL056C	YCL056C	PEX34	hom	Verified	1.64655088717729	0.049825196181056	no	349	0.0512737454184727	246	NA	FT	PEROXISOME ORGANIZATION			Peroxisomal integral membrane protein that regulates peroxisome populations; interacts with Pex11p, Pex25p, and Pex27p to control both constitutive peroxisome division and peroxisome morphology and abundance during peroxisome proliferation	peroxisome organization	molecular_function	integral to peroxisomal membrane|cytoplasm
YPR127W	YPR127W	YPR127W	hom	Verified	1.64000364881637	0.0505022041402919	no	350	0.0451285553672096	268	NA	FT	OXIDATION-REDUCTION PROCESS	NUCLEUS		Putative pyridoxine 4-dehydrogenase; differentially expressed during alcoholic fermentation; expression activated by transcription factor YRM1/YOR172W; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus	biological_process	molecular_function	nucleus|cytoplasm
YBR245C	YBR245C	ISW1	hom	Verified	1.63653148706211	0.0508642006838148	no	351	0.0443134741475529	239	NA	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS|CHROMOSOME		ATPase subunit of imitation-switch (ISWI) class chromatin remodelers; ATPase; forms a complex with Ioc3p (Isw1a), and a complex with Ioc2p and Ioc4p (Isw1b); Isw1a and Isw1b have partially overlapping and distinct roles, Isw1a involved in repression of transcription initiation and Isw1b involved in regulation of transcription elongation; Isw1b recruited to open reading frames by H3K36 methylation and acts with Chd1p to prevent trans-histone exchange over coding regions	termination of RNA polymerase I transcription|nucleosome positioning|termination of RNA polymerase II transcription|regulation of transcription by chromatin organization|DNA-dependent transcription, elongation|regulation of transcriptional start site selection at RNA polymerase II promoter|heterochromatin maintenance involved in chromatin silencing|chromatin remodeling|positive regulation of transcription from RNA polymerase II promoter	nucleosome binding|ATPase activity|rDNA binding|DNA binding	ISW1 complex|nucleolar chromatin
YNL224C	YNL224C	SQS1	hom	Verified	1.6339363434173	0.0511361087742249	no	352	0.0464609008865605	271	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEOTIDE METABOLISM	NUCLEUS		Protein that stimulates the ATPase and helicase activities of Prp43p; acts with Prp43p to stimulate 18s rRNA maturation by Nob1p; overexpression antagonizes the suppression of splicing defects by spp382 mutants; component of pre-ribosomal particles; relocalizes from nucleus to nucleolus upon DNA replication stress	positive regulation of helicase activity|positive regulation of ATPase activity|mRNA splicing, via spliceosome|maturation of SSU-rRNA|rRNA processing	molecular_function	preribosome, small subunit precursor|nucleus|preribosome, large subunit precursor|90S preribosome|cytoplasm
YLR237W	YLR237W	THI7	hom	Verified	1.63349478932884	0.0511824878649922	no	353	0.0697854140003246	218	NA	FT		PLASMA MEMBRANE		Plasma membrane transporter responsible for the uptake of thiamine, member of the major facilitator superfamily of transporters; mutation of human ortholog causes thiamine-responsive megaloblastic anemia	thiamine transport	thiamine transmembrane transporter activity	integral to membrane|plasma membrane
YOL073C	YOL073C	YOL073C	hom	Verified	1.62967960247754	0.0515846152861636	no	354	0.0488266051218988	221	NA					Subunit of the DSC ubiquitin ligase complex; ortholog of fission yeast dsc2	biological_process	molecular_function	integral to membrane
YLR342W	YLR342W	FKS1	hom	Verified	1.62693825912972	0.0518751056337896	no	355	0.0532139965174682	259	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	MITOCHONDRION|PLASMA MEMBRANE|CYTOSKELETON		Catalytic subunit of 1,3-beta-D-glucan synthase, functionally redundant with alternate catalytic subunit Gsc2p; binds to regulatory subunit Rho1p; involved in cell wall synthesis and maintenance; localizes to sites of cell wall remodeling	(1->3)-beta-D-glucan biosynthetic process|positive regulation of endocytosis|regulation of cell size	1,3-beta-D-glucan synthase activity	mitochondrion|1,3-beta-D-glucan synthase complex|integral to membrane|plasma membrane|cellular bud neck|cellular bud tip|actin cortical patch
YDR447C	YDR447C	RPS17B	hom	Verified	1.62554193148733	0.0520235683909492	no	356	0.0556800242658985	236	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Ribosomal protein 51 (rp51) of the small (40s) subunit; homologous to mammalian ribosomal protein S17, no bacterial homolog; RPS17B has a paralog, RPS17A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress	cytoplasmic translation|ribosomal small subunit assembly	structural constituent of ribosome	cytosolic small ribosomal subunit
YKL065C	YKL065C	YET1	hom	Verified	1.62438533847989	0.052146797099837	no	357	0.0363285322410563	177	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Endoplasmic reticulum transmembrane protein; may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein	biological_process	molecular_function	ribosome|integral to membrane|endoplasmic reticulum|endoplasmic reticulum membrane
YJL092W	YJL092W	SRS2	hom	Verified	1.62199563471496	0.0524021414092481	no	358	0.0540080846345957	292	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		DNA helicase and DNA-dependent ATPase involved in DNA repair and checkpoint recovery, needed for proper timing of commitment to meiotic recombination and transition from Meiosis I to II; blocks trinucleotide repeat expansion; affects genome stability	DNA repair|double-strand break repair via nonhomologous end joining|DNA duplex unwinding	DNA helicase activity	nucleus
YMR141C_d	YMR141C	YMR141C	hom	Dubious	1.620502446263	0.0525621946325725	no	359	0.0549717748280539	217	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YBL089W	YBL089W	AVT5	hom	Verified	1.62022609394079	0.0525918590383805	no	360	0.0700071478499334	260	NA					Putative transporter; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters; AVT5 has a paralog, AVT6, that arose from the whole genome duplication	transport	transporter activity	integral to membrane
YNL170W_d	YNL170W	YNL170W	hom	Dubious	1.61972325272693	0.0526458694564326	no	361	0.0662627123620595	344	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YJL028W	YJL028W	YJL028W	hom	Verified	1.61601414743699	0.0530456272283268	no	362	0.0316610220004899	144	NA					Protein of unknown function; may interact with ribosomes, based on co-purification experiments	biological_process	molecular_function	ribosome
YOR078W	YOR078W	BUD21	hom	Verified	1.60713480464398	0.0540123999092309	no	363	0.0526553443369711	248	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Component of small ribosomal subunit (SSU) processosome that contains U3 snoRNA; originally isolated as bud-site selection mutant that displays a random budding pattern	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	snoRNA binding	small-subunit processome|nucleolus|90S preribosome
YCR051W_p	YCR051W	YCR051W	hom	Uncharacterized	1.60698804376505	0.0540284954593873	no	364	0.0557681041647234	295	NA	FT		NUCLEUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; contains ankyrin (Ank) repeats; YCR051W is not an essential gene	biological_process	molecular_function	nucleus|cytoplasm
YMR107W	YMR107W	SPG4	hom	Verified	1.60363160242467	0.0543976402523	no	365	0.0360515132910578	169	NA					Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources	biological_process	molecular_function	cellular_component
YGL132W_d	YGL132W	YGL132W	hom	Dubious	1.60052425102643	0.0547411657222788	no	366	0.0373435768421623	195	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene SNT2/YGL131C	Unknown	Unknown	Unknown
YIR020W-A_d	YIR020W-A	YIR020W-A	hom	Dubious	1.59618293479131	0.0552239782538074	no	367	0.0633162091893924	250	NA					Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data	Unknown	Unknown	Unknown
YJR056C	YJR056C	YJR056C	hom	Verified	1.59224427948816	0.0556649137515023	no	368	0.0257841341771056	159	NA	FT		NUCLEUS		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; relative distribution to the nucleus increases upon DNA replication stress	biological_process	molecular_function	nucleus|cytoplasm
YLR255C_d	YLR255C	YLR255C	hom	Dubious	1.59202806488367	0.0556891993647634	no	369	0.0604717644062827	270	NA					Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YOL153C	YOL153C	YOL153C	hom	pseudogene	1.59134577300114	0.0557658904458959	no	370	0.0332656503940106	153	NA					Hypothetical protein	biological_process	molecular_function	cellular_component
YOL027C	YOL027C	MDM38	hom	Verified	1.58971734474358	0.0559492661150168	no	371	0.0652528835250016	269	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|TRANSLATION|ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS	MITOCHONDRION		Mitochondrial protein, forms a complex with Mba1p to facilitate recruitment of mRNA-specific translational activators to ribosomes; roles in protein export and K+/H+ exchange; human ortholog Letm1 implicated in Wolf-Hirschhorn syndrome	potassium ion transport|mitochondrial respiratory chain complex III biogenesis|cellular potassium ion homeostasis|proton transport|positive regulation of mitochondrial translation|mitochondrial respiratory chain complex IV biogenesis|protein insertion into mitochondrial membrane	ribosome binding	mitochondrion|mitochondrial inner membrane
YBL052C	YBL052C	SAS3	hom	Verified	1.58951237809453	0.0559723808673767	no	372	0.0649489046192282	280	NA	FT	CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS	HISTONE ACETYLTRANSFERASE	Histone acetyltransferase catalytic subunit of NuA3 complex that acetylates histone H3, involved in transcriptional silencing; homolog of the mammalian MOZ proto-oncogene; mutant has aneuploidy tolerance; sas3gcn5 double mutation is lethal	histone acetylation|chromatin modification|chromatin silencing at telomere|chromatin silencing at silent mating-type cassette	histone acetyltransferase activity	NuA3 histone acetyltransferase complex
YOR141C	YOR141C	ARP8	hom	Verified	1.5858170362816	0.0563904099713338	no	373	0.0620654741793819	334	NA	FT	CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME|CYTOSKELETON		Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes; has mRNA binding activity	mitotic recombination|response to DNA damage stimulus|chromatin remodeling	mRNA binding|ATP-dependent 3'-5' DNA helicase activity	nucleus|Ino80 complex
YER037W	YER037W	PHM8	hom	Verified	1.58501973218623	0.056480925546429	no	374	0.0597772939856049	289	NA	FT	RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Lysophosphatidic acid (LPA) phosphatase involved in LPA hydrolysis in response to phosphate starvation; phosphatase activity is soluble and Mg2+ dependent; expression is induced by low phosphate levels and by inactivation of Pho85p	cellular response to phosphate starvation	lysophosphatidic acid phosphatase activity	nucleus|cytoplasm
YLR209C	YLR209C	PNP1	hom	Verified	1.58474233503834	0.0565124444586154	no	375	0.0636238919892625	211	NA	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM			Purine nucleoside phosphorylase, specifically metabolizes inosine and guanosine nucleosides; involved in the nicotinamide riboside salvage pathway	guanosine catabolic process|inosine catabolic process|NAD biosynthesis via nicotinamide riboside salvage pathway|nicotinate nucleotide salvage	nicotinamide riboside hydrolase activity|inosine nucleosidase activity|purine-nucleoside phosphorylase activity	intracellular
YOR003W	YOR003W	YSP3	hom	Verified	1.58388291259183	0.0566101832824428	no	376	0.0438398670459685	226	NA	FT	PROTEOLYSIS			Putative precursor to the subtilisin-like protease III	protein catabolic process	peptidase activity	cellular_component
YCR105W	YCR105W	ADH7	hom	Verified	1.58371707093365	0.0566290591400141	no	377	0.0756249739766583	251	NA	FT	OXIDATION-REDUCTION PROCESS			NADPH-dependent medium chain alcohol dehydrogenase with broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance	alcohol metabolic process	alcohol dehydrogenase (NADP+) activity	cellular_component
YOR300W_d	YOR300W	YOR300W	hom	Dubious	1.5831755218869	0.0566907320044951	no	378	0.0402761515254003	179	NA					Dubious open reading frame, unlikely to encode a protein; overlaps with verified gene BUD7/YOR299W; mutation affects bipolar budding and bud site selection, though phenotype could be due to the mutation's effects on BUD7	Unknown	Unknown	Unknown
YJL106W	YJL106W	IME2	hom	Verified	1.58240427944836	0.0567786542051776	no	379	0.0504499407063521	197	NA	FT	CELL CYCLE|PROTEIN PHOSPHORYLATION	NUCLEUS		Serine/threonine protein kinase involved in activation of meiosis, associates with Ime1p and mediates its stability, activates Ndt80p; IME2 expression is positively regulated by Ime1p	protein phosphorylation|regulation of meiosis	protein kinase activity	nucleus
YMR089C	YMR089C	YTA12	hom	Verified	1.5815807920051	0.0568726508999059	no	380	0.0374210964125259	224	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Component, with Afg3p, of the mitochondrial inner membrane m-AAA protease that mediates degradation of misfolded or unassembled proteins and is also required for correct assembly of mitochondrial enzyme complexes	proteolysis|signal peptide processing|protein complex assembly|protein import into mitochondrial intermembrane space	metallopeptidase activity|protein binding|ATPase activity|ATP binding	mitochondrion|mitochondrial inner boundary membrane|mitochondrial inner membrane|m-AAA complex|cytoplasm
YNL093W	YNL093W	YPT53	hom	Verified	1.579310784913	0.057132394652479	no	381	0.0802714439823449	376	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING|VACUOLAR TRANSPORT	PLASMA MEMBRANE		Rab family GTPase; similar to Ypt51p and Ypt52p and to mammalian rab5; required for vacuolar protein sorting and endocytosis; YPT53 has a paralog, VPS21, that arose from the whole genome duplication	endocytosis|protein targeting to vacuole	GTPase activity	late endosome
YML026C	YML026C	RPS18B	hom	Verified	1.57927014443267	0.0571370534012287	no	382	0.0752065359745377	325	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION	MITOCHONDRION	RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S18 and bacterial S13; RPS18B has a paralog, RPS18A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress	cytoplasmic translation|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|rRNA export from nucleus	structural constituent of ribosome	cytosolic small ribosomal subunit|mitochondrion
YHR171W	YHR171W	ATG7	hom	Verified	1.57851843528594	0.0572232781623869	no	383	0.0930704426773355	348	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS	MITOCHONDRION		Autophagy-related protein and dual specificity member of the E1 family of ubiquitin-activating enzymes; mediates the conjugation of Atg12p with Atg5p and Atg8p with phosphatidylethanolamine, required steps in autophagosome formation	C-terminal protein lipidation|protein modification by small protein conjugation|piecemeal microautophagy of nucleus|mitochondrion degradation|macroautophagy|CVT pathway	APG8 activating enzyme activity|APG12 activating enzyme activity	cytosol|mitochondrion|membrane|pre-autophagosomal structure
YNL160W	YNL160W	YGP1	hom	Verified	1.57752358080671	0.0573375503086945	no	384	0.0540569992198093	251	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|CELL WALL ORG/BIOGENESIS			Cell wall-related secretory glycoprotein; induced by nutrient deprivation-associated growth arrest and upon entry into stationary phase; may be involved in adaptation prior to stationary phase entry; has similarity to Sps100p	cell wall assembly	molecular_function	extracellular region
YER092W	YER092W	IES5	hom	Verified	1.5772857306894	0.0573648971071141	no	385	0.0693481083662028	376	NA	FT		NUCLEUS		Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions	biological_process	molecular_function	nucleus
YIL020C	YIL020C	HIS6	hom	Verified	1.57607391157058	0.0575043852837169	no	386	0.0608424380912557	277	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Phosphoribosyl-5-amino-1-phosphoribosyl-4-imidazolecarboxiamide isomerase, catalyzes the fourth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts	histidine biosynthetic process	1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity	intracellular
YDR538W	YDR538W	PAD1	hom	Verified	1.57465420925678	0.0576681413828216	no	387	0.0521243141214577	317	NA	FT	KETONE METABOLISM	MITOCHONDRION		Phenylacrylic acid decarboxylase, confers resistance to cinnamic acid, decarboxylates aromatic carboxylic acids to the corresponding vinyl derivatives; also has mRNA binding activity; homolog of E. coli UbiX	cinnamic acid catabolic process|aromatic compound catabolic process	mRNA binding|carboxy-lyase activity	mitochondrion
YJR097W	YJR097W	JJJ3	hom	Verified	1.57331681030118	0.0578227394003911	no	388	0.0655277029279829	301	NA	FT		NUCLEUS		Protein of unknown function, contains a CSL Zn finger and a DnaJ-domain; involved in diphthamide biosynthesis; ortholog human Dph4	peptidyl-diphthamide biosynthetic process from peptidyl-histidine	ferrous iron binding	nucleus|cytoplasm
YGL084C	YGL084C	GUP1	hom	Verified	1.5728969616538	0.057871339380578	no	389	0.148783992633714	584	NA	FF|FT	LIPID METABOLISM|CARBOHYDRATE METABOLISM	ENDOPLASMIC RETICULUM|PLASMA MEMBRANE		Plasma membrane protein involved in remodeling GPI anchors; member of the MBOAT family of putative membrane-bound O-acyltransferases; proposed to be involved in glycerol transport	GPI anchor biosynthetic process|glycerol transport|glycerol catabolic process	O-acyltransferase activity	integral to membrane|endoplasmic reticulum|plasma membrane|membrane
YMR172W	YMR172W	HOT1	hom	Verified	1.57134352657481	0.0580514379883023	no	390	0.0418006751478663	220	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Transcription factor required for the transient induction of glycerol biosynthetic genes GPD1 and GPP2 in response to high osmolarity; targets Hog1p to osmostress responsive promoters; has similarity to Msn1p and Gcr1p	cellular hyperosmotic salinity response|RNA polymerase II transcriptional preinitiation complex assembly|positive regulation of transcription from RNA polymerase II promoter in response to osmotic stress|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly|sequence-specific DNA binding RNA polymerase II transcription factor activity	nucleus
YPR132W	YPR132W	RPS23B	hom	Verified	1.56977040170142	0.0582342679069962	no	391	0.0538102463939687	228	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit, required for translational accuracy; homologous to mammalian ribosomal protein S23 and bacterial S12; RPS23B has a paralog, RPS23A, that arose from the whole genome duplication; deletion of both RPS23A and RPS23B is lethal	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|regulation of translational fidelity	structural constituent of ribosome	cytosolic small ribosomal subunit
YOR080W	YOR080W	DIA2	hom	Verified	1.56683689850954	0.0585764101059692	no	392	0.0652419045466043	264	NA	FT	CELL CYCLE|PROTEOLYSIS	NUCLEUS|CHROMOSOME	UBIQUITIN LIGASE COMPLEX	Origin-binding F-box protein; forms an SCF ubiquitin ligase complex with Skp1p and Cdc53p; plays a role in DNA replication; plays a role in transcription; required for correct assembly of RSC complex, correct RSC-mediated transcription regulation, and correct nucleosome positioning; involved in invasive and pseudohyphal growth; required to target Cdc6p for ubiquitin-mediated destruction during G1 phase	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|regulation of DNA replication|invasive growth in response to glucose limitation|protein ubiquitination	ubiquitin-protein ligase activity|DNA replication origin binding	SCF ubiquitin ligase complex|nucleus|nuclear replication fork
YLR354C	YLR354C	TAL1	hom	Verified	1.56197791289203	0.0591465960923795	no	393	0.0822039236402142	280	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		Transaldolase, enzyme in the non-oxidative pentose phosphate pathway; converts sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate to erythrose 4-phosphate and fructose 6-phosphate	pentose-phosphate shunt	sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity	nucleus|cytoplasm
YPL123C	YPL123C	RNY1	hom	Verified	1.56187476378312	0.0591587473190472	no	394	0.0415164612159267	189	NA					Vacuolar RNase of the T(2) family, relocalizes to the cytosol where it cleaves tRNAs upon oxidative or stationary phase stress; promotes apoptosis under stress conditions and this function is independent of its catalytic activity	cell morphogenesis|RNA catabolic process|apoptotic process	endoribonuclease activity	cytosol|extracellular region|vacuole
YDR335W	YDR335W	MSN5	hom	Verified	1.5606644274532	0.0593014743223724	no	395	0.0728999046974507	333	NA	FT	PROTEIN LOCALIZATION|RNA LOCALIZATION	NUCLEUS		Karyopherin involved in nuclear import and export of proteins, including import of replication protein A and export of Swi6p, Far1p, and Pho4p; required for re-export of mature tRNAs after their retrograde import from the cytoplasm	tRNA re-export from nucleus|protein export from nucleus	protein binding|importin-alpha export receptor activity	integral to membrane|nucleus|cytoplasm
YDL226C	YDL226C	GCS1	hom	Verified	1.55939522455698	0.0594514329403147	no	396	0.0967808938710302	499	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL CYCLE|SIGNALING|NUCLEOTIDE METABOLISM|CYTOSKELETON ORGANIZATION	MITOCHONDRION|GOLGI APPARATUS|CYTOSKELETON		ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Glo3p	retrograde vesicle-mediated transport, Golgi to ER|Golgi to plasma membrane protein transport|actin filament reorganization involved in cell cycle|ER to Golgi vesicle-mediated transport	actin binding|ARF GTPase activator activity|GTPase activator activity	endosome|trans-Golgi network|endoplasmic reticulum-Golgi intermediate compartment|cytoskeleton
YGR015C_p	YGR015C	YGR015C	hom	Uncharacterized	1.55291758981501	0.0602214119729931	no	397	0.0701856443594603	249	NA	FT		MITOCHONDRION		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion	biological_process	molecular_function	mitochondrion
YOR202W	YOR202W	HIS3	hom	Verified	1.55150974962845	0.0603897863561743	no	398	0.0410879596136431	193	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p	histidine biosynthetic process	imidazoleglycerol-phosphate dehydratase activity	cellular_component
YAL058W	YAL058W	CNE1	hom	Verified	1.54464079845845	0.0612165859947539	no	399	0.055087751242957	277	NA	FT	PROTEOLYSIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Calnexin; integral membrane ER chaperone involved in folding and quality control of glycoproteins; chaperone activity is inhibited by Mpd1p, with which Cne1p interacts; 24% identical to mammalian calnexin; Ca+ binding not yet shown in yeast	protein folding|ER-associated protein catabolic process	unfolded protein binding	integral to endoplasmic reticulum membrane
YNL228W_d	YNL228W	YNL228W	hom	Dubious	1.54197584643268	0.0615397315707856	no	400	0.0787522038055388	337	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps ORF YNL227C/JJJ1	Unknown	Unknown	Unknown
YNR002C	YNR002C	ATO2	hom	Verified	1.5414027874804	0.0616093930225613	no	401	0.0439189157221226	217	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION|PLASMA MEMBRANE		Putative transmembrane protein involved in export of ammonia; ammonia is a starvation signal that promotes cell death in aging colonies; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family; homolog of Y. lipolytica Gpr1p; ATO2 has a paralog, ADY2, that arose from the whole genome duplication	ammonium transport|nitrogen utilization	ammonium transmembrane transporter activity	mitochondrion|integral to membrane|plasma membrane
YKL205W	YKL205W	LOS1	hom	Verified	1.54107122233435	0.0616497264274	no	402	0.0642961963253985	227	NA	FT	RNA PROCESSING|RNA LOCALIZATION	NUCLEUS|MITOCHONDRION		Nuclear pore protein involved in nuclear export of pre-tRNA and in re-export of mature tRNAs after their retrograde import from the cytoplasm	tRNA re-export from nucleus|tRNA splicing, via endonucleolytic cleavage and ligation|tRNA export from nucleus	tRNA binding|Ran GTPase binding	mitochondrion|integral to membrane|nuclear matrix|cytoplasm
YJR052W	YJR052W	RAD7	hom	Verified	1.54007994919349	0.0617704333008568	no	403	0.0579701577982884	224	NA	FT	RESPONSE TO DNA DAMAGE|PROTEOLYSIS	NUCLEUS	UBIQUITIN LIGASE COMPLEX	Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad16p) during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex	nucleotide-excision repair, DNA damage recognition|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	damaged DNA binding|ubiquitin-protein ligase activity|DNA-dependent ATPase activity	nucleotide-excision repair factor 4 complex|Cul3-RING ubiquitin ligase complex
YJL004C	YJL004C	SYS1	hom	Verified	1.53666948297254	0.0621871339216342	no	404	0.116106593807282	525	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Integral membrane protein of the Golgi required for targeting of the Arf-like GTPase Arl3p to the Golgi; multicopy suppressor of ypt6 null mutation	vesicle organization|Golgi to plasma membrane protein transport|Golgi to endosome transport	molecular_function	trans-Golgi network|integral to membrane|integral to Golgi membrane
YMR100W	YMR100W	MUB1	hom	Verified	1.53608463862531	0.0622588116436631	no	405	0.0764632132559221	302	NA	FT	CELL DIVISION			MYND domain-containing protein required for ubiquitination and turnover of Rpn4p; interacts with Ubr2p (E3) and indirectly with Rad6p (E2); short-lived protein degraded in a Ubr2p/Rad6p dependent manner; similar to the A. nidulans samB gene	regulation of cell budding|protein monoubiquitination	molecular_function	cellular_component
YKL221W	YKL221W	MCH2	hom	Verified	1.53601841952566	0.0622669314252267	no	406	0.0726353937454873	226	NA					Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport	transport	monocarboxylic acid transmembrane transporter activity|transporter activity	integral to membrane|membrane
YMR097C	YMR097C	MTG1	hom	Verified	1.53489921671827	0.0624042929858828	no	407	0.0777673397231787	360	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Putative GTPase peripheral to the mitochondrial inner membrane, essential for respiratory competence, likely functions in assembly of the large ribosomal subunit, has homologs in plants and animals	mitochondrial translation	GTPase activity	mitochondrion|mitochondrial inner membrane
YBL049W	YBL049W	MOH1	hom	Verified	1.53423519433614	0.0624859011326225	no	408	0.0838221838394924	409	NA					Protein of unknown function, has homology to kinase Snf7p; not required for growth on nonfermentable carbon sources; essential for survival in stationary phase	biological_process	molecular_function	cellular_component
YAL011W	YAL011W	SWC3	hom	Verified	1.53004550313583	0.0630027330649887	no	409	0.092852443704724	432	NA	FF|FT	CHROMATIN ORGANIZATION	NUCLEUS|MITOCHONDRION|CHROMOSOME		Protein of unknown function, component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for formation of nuclear-associated array of smooth endoplasmic reticulum known as karmellae	endoplasmic reticulum organization|chromatin remodeling|histone exchange	molecular_function	mitochondrion|Swr1 complex|nucleus
YML055W	YML055W	SPC2	hom	Verified	1.5289502997041	0.0631383826562491	no	410	0.0797781075117575	348	NA	FT	PROTEIN LOCALIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Subunit of signal peptidase complex (Spc1p, Spc2p, Spc3p, Sec11p), which catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC25	signal peptide processing|protein targeting to ER	peptidase activity	signal peptidase complex
YGL125W	YGL125W	MET13	hom	Verified	1.52590507205238	0.0635167536782447	no	411	0.0700207734610086	221	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS	MITOCHONDRION		Major isozyme of methylenetetrahydrofolate reductase, catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate in the methionine biosynthesis pathway	methionine biosynthetic process	methylenetetrahydrofolate reductase (NADPH) activity	mitochondrion
YML121W	YML121W	GTR1	hom	Verified	1.52320120179378	0.0638541877645041	no	412	0.0991298436814994	417	NA	FF|FT	PROTEIN LOCALIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS|GENE SILENCING	NUCLEUS		Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB	phosphate ion transport|transcription from RNA polymerase I promoter|transcription from RNA polymerase III promoter|chromatin silencing at telomere	GDP binding|GTP binding	fungal-type vacuole membrane|EGO complex|nucleus|late endosome membrane|cytoplasm
YPR067W	YPR067W	ISA2	hom	Verified	1.52078814118217	0.0641565056546872	no	413	0.0898614514743536	386	NA	FT	KETONE METABOLISM|COFACTOR METABOLISM	MITOCHONDRION		Protein required for maturation of mitochondrial [4Fe-4S] proteins; functions in a complex with Isa1p and possibly Iba57p; localizes to the mitochondrial intermembrane space, overexpression of ISA2 suppresses grx5 mutations	iron-sulfur cluster assembly|biotin biosynthetic process	iron ion binding	mitochondrion|mitochondrial intermembrane space
YLR227C	YLR227C	ADY4	hom	Verified	1.50852860716591	0.0657096453584242	no	414	0.0504884591937932	227	NA	FT	CELL CYCLE|CELL DIVISION	NUCLEUS|CYTOSKELETON		Structural component of the meiotic outer plaque, which is a membrane-organizing center that assembles on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane	sporulation resulting in formation of a cellular spore	structural molecule activity	spindle pole body
YHR060W	YHR060W	VMA22	hom	Verified	1.50598851966981	0.0660350604027053	no	415	0.0661262757355457	269	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|ION HOMEOSTASIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Peripheral membrane protein that is required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the yeast endoplasmic reticulum (ER)	vacuolar proton-transporting V-type ATPase complex assembly|vacuolar acidification	unfolded protein binding	extrinsic to endoplasmic reticulum membrane
YMR230W	YMR230W	RPS10B	hom	Verified	1.50567645503826	0.0660751255195148	no	416	0.0740262635872011	303	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10B has a paralog, RPS10A, that arose from the whole genome duplication	cytoplasmic translation|rRNA export from nucleus	structural constituent of ribosome	cytosolic small ribosomal subunit
YDL067C	YDL067C	COX9	hom	Verified	1.5045723595484	0.0662170284886219	no	417	0.0680050485487802	327	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Subunit VIIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain	mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity	mitochondrion|integral to membrane|mitochondrial respiratory chain complex IV
YHR157W	YHR157W	REC104	hom	Verified	1.50325757694785	0.0663863176132821	no	418	0.0568009739894646	302	NA	FT	CELL CYCLE	NUCLEUS|CHROMOSOME		Protein involved in early stages of meiotic recombination; required for meiotic crossing over; forms a complex with Rec102p and Spo11p necessary during the initiation of recombination	meiotic DNA double-strand break formation|reciprocal meiotic recombination	molecular_function	condensed nuclear chromosome
YLL014W	YLL014W	EMC6	hom	Verified	1.50176418422878	0.0665790105486976	no	419	0.0875781988755468	387	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm F33D4.7/EMC-6, fly CG11781, human TMEM93	protein folding in endoplasmic reticulum	molecular_function	ER membrane protein complex|integral to membrane|endoplasmic reticulum
YER118C	YER118C	SHO1	hom	Verified	1.50088707496522	0.0666923858715887	no	420	0.0629375982680864	246	NA	FT	SIGNALING	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Transmembrane osmosensor involved in activation of the Cdc42p- and MAP kinase-dependent filamentous growth pathway and the high-osmolarity glycerol response pathway; phosphorylated by Hog1p; interacts with Pbs2p, Msb2p, Hkr1p, and Ste11p	signal transduction involved in filamentous growth|establishment of cell polarity|osmosensory signaling pathway|cellular response to heat|cytokinesis	osmosensor activity|MAP-kinase scaffold activity	integral to membrane|plasma membrane|plasma membrane part|cellular bud|cellular bud neck|mating projection tip
YBR260C	YBR260C	RGD1	hom	Verified	1.49547057413297	0.0673958369796732	no	421	0.0476553476415007	228	NA	FT	SIGNALING	SITE OF POLARIZED GROWTH|CYTOSKELETON		GTPase-activating protein (RhoGAP) for Rho3p and Rho4p, possibly involved in control of actin cytoskeleton organization	response to acid|osmosensory signaling pathway	Rho GTPase activator activity|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4-phosphate binding|phosphatidylinositol-5-phosphate binding	cellular bud|mating projection tip|actin cortical patch
YOL025W	YOL025W	LAG2	hom	Verified	1.49273298177891	0.0677535481594405	no	422	0.0709832360260647	297	NA	FT		MITOCHONDRION		Protein that negatively regulates the SCF E3-ubiquitin ligase by interacting with and preventing neddyation of the cullin subunit, Cdc53p; longevity determinant that is preferentially expressed in young cells; similar to mammalian Cand1	replicative cell aging|negative regulation of ubiquitin-protein ligase activity	molecular_function	mitochondrion
YOR215C	YOR215C	AIM41	hom	Verified	1.49226510677346	0.0678148301468963	no	423	0.0583157642179366	255	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays reduced frequency of mitochondrial genome loss	biological_process	molecular_function	mitochondrion
YGR104C	YGR104C	SRB5	hom	Verified	1.49027785140139	0.0680755968400865	no	424	0.0755931777895998	330	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS	RNA POL II, HOLOENZYME	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; required for proper termination of transcription for some genes; involved in telomere maintenance	transcriptional open complex formation at RNA polymerase II promoter|RNA polymerase II transcriptional preinitiation complex assembly|positive regulation of transcription from RNA polymerase II promoter	core RNA polymerase II binding transcription factor activity|RNA polymerase II transcription factor recruiting transcription factor activity|TBP-class protein binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly	core mediator complex
YDL037C	YDL037C	BSC1	hom	Verified	1.48505635869013	0.0687644476644573	no	425	0.0732344092225746	310	NA					Protein of unconfirmed function, similar to cell surface flocculin Flo11p; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression	biological_process	molecular_function	cellular_component
YNL108C_p	YNL108C	YNL108C	hom	Uncharacterized	1.48450904366029	0.0688369628652904	no	426	0.0877402222997315	340	NA	FT		NUCLEUS		Putative protein of unknown function; similar to prokaryotic phosphotransfer enzymes; null mutant shows alterations in glucose metabolism; GFP-fusion protein localizes to the cytoplasm and nucleus; YNL108C has a paralog, TFC7, that arose from the whole genome duplication	biological_process	molecular_function	nucleus|cytoplasm
YGR228W_d	YGR228W	YGR228W	hom	Dubious	1.48066521641384	0.0693479036658248	no	427	0.0994459800225873	414	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SMI1/YGR229C	Unknown	Unknown	Unknown
YPL178W	YPL178W	CBC2	hom	Verified	1.47700904165823	0.0698366068070199	no	428	0.0614127721689404	304	NA	FT	RNA PROCESSING|RNA LOCALIZATION	NUCLEUS		Small subunit of the heterodimeric cap binding complex that also contains Sto1p, component of the spliceosomal commitment complex; interacts with Npl3p, possibly to package mRNA for export from the nucleus; contains an RNA-binding motif	mRNA splicing, via spliceosome	RNA cap binding	commitment complex|nuclear cap binding complex
YBL005W	YBL005W	PDR3	hom	Verified	1.47066963300998	0.0706902412107438	no	429	0.0692651329467989	285	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Transcriptional activator of the pleiotropic drug resistance network; regulates expression of ATP-binding cassette (ABC) transporters through binding to cis-acting sites known as PDREs (PDR responsive elements); post-translationally up-regulated in cells lacking a functional mitochondrial genome; PDR3 has a paralog, PDR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress	Unknown|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus|cytoplasm
YPL271W	YPL271W	ATP15	hom	Verified	1.46795048784616	0.0710588362655026	no	430	0.0951501109099033	316	NA	FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS	MITOCHONDRION		Epsilon subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated	ATP synthesis coupled proton transport	hydrogen ion transporting ATP synthase activity, rotational mechanism|ATPase activity|proton-transporting ATPase activity, rotational mechanism	proton-transporting ATP synthase complex, catalytic core F(1)|mitochondrion|integral to membrane|mitochondrial proton-transporting ATP synthase, central stalk
YMR206W_p	YMR206W	YMR206W	hom	Uncharacterized	1.46786192147948	0.0710708666961992	no	431	0.0585595010118108	260	NA					Putative protein of unknown function; not an essential gene; YMR206W has a paralog, YNR014W, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YLR352W_p	YLR352W	YLR352W	hom	Uncharacterized	1.46627508429422	0.0712866802189251	no	432	0.0626797957308484	268	NA					Putative protein of unknown function with similarity to F-box proteins; interacts with Skp1p and Cdc53p; YLR352W is not an essential gene	biological_process	molecular_function	SCF ubiquitin ligase complex
YOR284W	YOR284W	HUA2	hom	Verified	1.46506322268081	0.0714518347327402	no	433	0.0665082906164203	243	NA					Cytoplasmic protein of unknown function; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin patch assembly	biological_process	molecular_function	cytoplasm
YER188W_d	YER188W	YER188W	hom	Dubious	1.46397180226607	0.0716008264940386	no	434	0.0932214454967555	351	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; large-scale analyses show mRNA expression increases under anaerobic conditions and two-hybrid interactions with Sst2p	Unknown	Unknown	Unknown
YNL005C	YNL005C	MRP7	hom	Verified	1.46241785683129	0.0718133695203313	no	435	0.127073039632417	427	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation	structural constituent of ribosome|peptidyltransferase activity	mitochondrion|mitochondrial large ribosomal subunit
YJL122W	YJL122W	ALB1	hom	Verified	1.46191362658787	0.0718824401877973	no	436	0.0519632705336719	230	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS	NUCLEUS		Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit; interacts directly with Arx1p; responsible for Tif6p recycling defects in absence of Rei1p	ribosomal large subunit biogenesis	molecular_function	ribosome|nucleus|cytoplasm
YNL001W	YNL001W	DOM34	hom	Verified	1.46149764131026	0.0719394611902525	no	437	0.0781735845104483	339	NA	FT	CELL CYCLE|TRANSLATION|CELL DIVISION			Protein that facilitates ribosomal subunit dissociation; acts when translation is stalled, with binding partner Hbs1p; required for RNA cleavage in no-go decay, but reports conflict on endonuclease activity; Pelota ortholog; protein abundance increases in response to DNA replication stress; DOM34 has a paralog, YCL001W-B, that arose from the whole genome duplication	nuclear-transcribed mRNA catabolic process, no-go decay|ribosome disassembly|nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay|nonfunctional rRNA decay	ribosome binding|endoribonuclease activity	cytoplasm
YNL328C	YNL328C	MDJ2	hom	Verified	1.45583455087568	0.0727191809861659	no	438	0.0895852488531648	320	NA	FT	PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Constituent of the mitochondrial import motor associated with the presequence translocase; function overlaps with that of Pam18p; stimulates the ATPase activity of Ssc1p to drive mitochondrial import; contains a J domain	protein import into mitochondrial matrix	protein transporter activity|ATPase activator activity	mitochondrial inner membrane|presequence translocase-associated import motor
YFR034C	YFR034C	PHO4	hom	Verified	1.45438187968403	0.0729202304462252	no	439	0.105556713897823	448	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Basic helix-loop-helix (bHLH) transcription factor of the myc-family; activates transcription cooperatively with Pho2p in response to phosphate limitation; binding to 'CACGTG' motif is regulated by chromatin restriction, competitive binding of Cbf1p to the same DNA binding motif and cooperation with Pho2p,; function is regulated by phosphorylation at multiple sites and by phosphate availability	cellular response to phosphate starvation|positive regulation of phosphate metabolic process|phosphate-containing compound metabolic process|chromatin remodeling|positive regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	nucleus|cytoplasm
YEL009C	YEL009C	GCN4	hom	Verified	1.45334098444301	0.0730645516526685	no	440	0.189195928068003	741	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|PROTEIN COMPLEX ORG/BIOGENESIS|AMINO ACID METABOLISM|RIBOSOME BIOGENESIS|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Basic leucine zipper (bZIP) transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels	nitrogen catabolite activation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|positive regulation of RNA polymerase II transcriptional preinitiation complex assembly|positive regulation of transcription initiation from RNA polymerase II promoter|negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter in response to nutrient levels	chromatin binding|TFIID-class binding transcription factor activity|sequence-specific DNA binding|RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II transcription factor recruiting transcription factor activity|RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription|sequence-specific DNA binding transcription factor activity	nucleus
YMR123W	YMR123W	PKR1	hom	Verified	1.45322098635318	0.0730812035552778	no	441	0.135556848694086	516	NA	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		V-ATPase assembly factor; functions with other V-ATPase assembly factors in the ER to efficiently assemble the V-ATPase membrane sector (V0); protein abundance increases in response to DNA replication stress	vacuolar proton-transporting V-type ATPase complex assembly	molecular_function	integral to endoplasmic reticulum membrane
YJR104C	YJR104C	SOD1	hom	Verified	1.45138079733093	0.0733369269210825	no	442	0.179971324075897	670	NA	FF|FT	ION HOMEOSTASIS|CELL WALL ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|RESPONSE TO OXIDATIVE STRESS	NUCLEUS|MITOCHONDRION		Cytosolic copper-zinc superoxide dismutase; some mutations are analogous to those that cause ALS (amyotrophic lateral sclerosis) in humans; protein abundance increases in response to DNA replication stress and in response to prolonged exposure to boric acid	cellular copper ion homeostasis|fungal-type cell wall organization|superoxide metabolic process|cellular zinc ion homeostasis|positive regulation of sequence-specific DNA binding transcription factor activity|age-dependent response to reactive oxygen species involved in chronological cell aging	superoxide dismutase activity	cytosol|mitochondrion|nucleus|mitochondrial intermembrane space
YIL001W_p	YIL001W	YIL001W	hom	Uncharacterized	1.45042907168021	0.0734694525106062	no	443	0.0876315775363816	308	NA					Putative protein of unknown function; contains a BTB/POZ domain which generally function in protein interactions; deletion slightly improved competitive fitness in rich media; GFP-tagged protein is localized to the cytoplasm	biological_process	molecular_function	cytoplasm
YJR050W	YJR050W	ISY1	hom	Verified	1.4491156449128	0.0736526448167533	no	444	0.0953663288349109	344	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING	NUCLEUS		Member of NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of spliceosome containing U2, U5, and U6 snRNAs, interacts with Prp16p to modulate splicing fidelity; isy1 syf2 cells have defective spindles	generation of catalytic spliceosome for second transesterification step|mRNA 3'-splice site recognition	first spliceosomal transesterification activity|second spliceosomal transesterification activity	post-spliceosomal complex|Prp19 complex|post-mRNA release spliceosomal complex|U2-type catalytic step 2 spliceosome|U2-type catalytic step 1 spliceosome
YIR001C	YIR001C	SGN1	hom	Verified	1.44829927646084	0.0737666849726751	no	445	0.0695141543631275	268	NA					Cytoplasmic RNA-binding protein, contains an RNA recognition motif (RRM); may have a role in mRNA translation, as suggested by genetic interactions with genes encoding proteins involved in translational initiation	mRNA metabolic process	poly(A) RNA binding	cytoplasm
YBR069C	YBR069C	TAT1	hom	Verified	1.44724773784717	0.073913775344209	no	446	0.243684655489744	816	NA	FF|FT		PLASMA MEMBRANE		Amino acid transporter for valine, leucine, isoleucine, and tyrosine; low-affinity tryptophan and histidine transporter; overexpression confers FK506 and FTY720 resistance; protein abundance increases in response to DNA replication stress	amino acid transport|tyrosine transport|tryptophan transport|transmembrane transport	amino acid transmembrane transporter activity|low-affinity tryptophan transmembrane transporter activity	integral to membrane|plasma membrane
YAR002W	YAR002W	NUP60	hom	Verified	1.44684889570284	0.0739696244083576	no	447	0.0920457454943082	346	NA	FT	PROTEIN LOCALIZATION|RESPONSE TO DNA DAMAGE|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier and is involved in gene tethering at the nuclear periphery; both NUP1 and NUP60 are homologous to human NUP153	double-strand break repair|poly(A)+ mRNA export from nucleus|protein export from nucleus|regulation of protein desumoylation|intracellular mRNA localization|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|telomere tethering at nuclear periphery|mRNA export from nucleus in response to heat stress|transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery|NLS-bearing substrate import into nucleus|chromosome organization|nucleocytoplasmic transport|chromatin silencing at silent mating-type cassette	nucleocytoplasmic transporter activity|phospholipid binding|structural constituent of nuclear pore	nuclear pore central transport channel|nuclear pore nuclear basket|integral to membrane|nuclear pore
YOL033W	YOL033W	MSE1	hom	Verified	1.44566077288093	0.0741361859545929	no	448	0.103223755994256	389	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial glutamyl-tRNA synthetase, predicted to be palmitoylated	mitochondrial glutamyl-tRNA aminoacylation|glutamyl-tRNA aminoacylation|mitochondrial translation	glutamate-tRNA(Gln) ligase activity|glutamate-tRNA ligase activity	mitochondrion
YKL071W_p	YKL071W	YKL071W	hom	Uncharacterized	1.44420937655536	0.0743400440686218	no	449	0.0788070241156688	301	NA	FT	OXIDATION-REDUCTION PROCESS			Putative protein of unknown function; expression induced in cells treated with the mycotoxin patulin, and also the quinone methide triterpene celastrol; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	biological_process	molecular_function	integral to membrane|cytoplasm
YPR011C_p	YPR011C	YPR011C	hom	Uncharacterized	1.44121870533579	0.0747614527477862	no	450	0.0487870535913304	213	NA	FT		MITOCHONDRION		Putative transporter, member of the mitochondrial carrier family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	transport	transporter activity	mitochondrion|integral to membrane|mitochondrial inner membrane
YPL214C	YPL214C	THI6	hom	Verified	1.43869281020793	0.0751187886510715	no	451	0.0606644899604045	284	NA					Bifunctional enzyme with thiamine-phosphate pyrophosphorylase and 4-methyl-5-beta-hydroxyethylthiazole kinase activities, required for thiamine biosynthesis; GFP-fusion protein localizes to the cytoplasm in a punctate pattern	thiamine biosynthetic process	hydroxyethylthiazole kinase activity|thiamine-phosphate diphosphorylase activity	cytosol|cytoplasm
YMR122C_d	YMR122C	YMR122C	hom	Dubious	1.43757299212634	0.075277624286143	no	452	0.102035014245657	348	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YKL197C	YKL197C	PEX1	hom	Verified	1.43708382032348	0.0753470889900845	no	453	0.0712664527518626	300	NA	FT	PROTEIN LOCALIZATION|SIGNALING|PEROXISOME ORGANIZATION			AAA-peroxin that heterodimerizes with AAA-peroxin Pex6p and participates in the recycling of peroxisomal signal receptor Pex5p from the peroxisomal membrane to the cystosol; induced by oleic acid and upregulated during anaerobiosis	protein import into peroxisome matrix, receptor recycling	ATPase activity|protein heterodimerization activity	peroxisomal membrane|peroxisome
YMR194W	YMR194W	RPL36A	hom	Verified	1.43697745824136	0.0753621993724357	no	454	0.0654152063418631	322	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L36A; N-terminally acetylated; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L36, no bacterial homolog; RPL36A has a paralog, RPL36B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome|RNA binding	cytosolic large ribosomal subunit
YGR257C	YGR257C	MTM1	hom	Verified	1.43521059639	0.0756135474807502	no	455	0.109196516831412	472	NA	FF|FT	ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Mitochondrial protein of the mitochondrial carrier family, involved in activating mitochondrial Sod2p probably by facilitating insertion of an essential manganese cofactor	manganese ion transport|transport	transporter activity|metallochaperone activity	mitochondrion|integral to membrane|mitochondrial inner membrane
YBR059C	YBR059C	AKL1	hom	Verified	1.4349929919854	0.0756445473084243	no	456	0.0791385454284556	341	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION	SITE OF POLARIZED GROWTH		Ser-Thr protein kinase, member (with Ark1p and Prk1p) of the Ark kinase family; involved in endocytosis and actin cytoskeleton organization	regulation of endocytosis|protein phosphorylation|actin cytoskeleton organization	protein kinase activity	cellular bud neck|cytoplasm
YCR019W	YCR019W	MAK32	hom	Verified	1.43214180315141	0.0760516214779376	no	457	0.0721963998901837	299	NA					Protein necessary for structural stability of L-A double-stranded RNA-containing particles	interspecies interaction between organisms	molecular_function	cellular_component
YGR130C	YGR130C	YGR130C	hom	Verified	1.43194806337347	0.0760793427768302	no	458	0.0963027178207249	382	NA					Component of the eisosome with unknown function; GFP-fusion protein localizes to the cytoplasm; specifically phosphorylated in vitro by mammalian diphosphoinositol pentakisphosphate (IP7)	biological_process	molecular_function	eisosome|membrane raft|cytoplasm
YBR067C	YBR067C	TIP1	hom	Verified	1.43112134177146	0.0761977208718048	no	459	0.0664246734275342	286	NA	FT	CELL WALL ORG/BIOGENESIS			Major cell wall mannoprotein with possible lipase activity; transcription is induced by heat- and cold-shock; member of the Srp1p/Tip1p family of serine-alanine-rich proteins	fungal-type cell wall organization	structural constituent of cell wall|lipase activity	fungal-type cell wall
YPR123C_d	YPR123C	YPR123C	hom	Dubious	1.42299138159153	0.0773693268249934	no	460	0.189096231236175	703	NA	FF				Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially/completely overlaps the verified ORF CTR	Unknown	Unknown	Unknown
YER028C	YER028C	MIG3	hom	Verified	1.41787086062603	0.07811423559727	no	461	0.0753484312721212	329	NA	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Transcriptional regulator; partially nonfunctional in S288C strains but has a major role in catabolite repression and ethanol response in some other strains; involved in response to toxic agents; phosphorylation by Snf1p or the Mec1p pathway inactivates Mig3p, allowing induction of damage response genes; MIG3 has a paralog, MIG2, that arose from the whole genome duplication	cellular response to UV|negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage|response to DNA damage stimulus	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding	nuclear chromatin
YHR105W	YHR105W	YPT35	hom	Verified	1.41503438360434	0.0785292075211336	no	462	0.0692171322593405	315	NA					Endosomal protein of unknown function that contains a phox (PX) homology domain and binds to both phosphatidylinositol-3-phosphate (PtdIns(3)P) and proteins involved in ER-Golgi or vesicular transport	biological_process	phosphatidylinositol-3-phosphate binding	endosome
YGR236C	YGR236C	SPG1	hom	Verified	1.41451710984732	0.078605063650854	no	463	0.0753390396564675	300	NA	FT		MITOCHONDRION		Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YPL041C_p	YPL041C	YPL041C	hom	Uncharacterized	1.41439792121149	0.0786225500580735	no	464	0.0754898390665382	231	NA					Protein of unknown function involved in maintenance of proper telomere length	biological_process	molecular_function	cellular_component
YMR310C_p	YMR310C	YMR310C	hom	Uncharacterized	1.4138040603404	0.0787097205382584	no	465	0.0866581943491799	348	NA	FT		NUCLEUS		Putative S-adenosylmethionine-dependent methyltransferase; predicted to be involved in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR310C is not an essential gene	biological_process	S-adenosylmethionine-dependent methyltransferase activity	nucleus
YML028W	YML028W	TSA1	hom	Verified	1.40848009617241	0.0794944783140278	no	466	0.0704633625603775	326	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|TRANSLATION|OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS			Thioredoxin peroxidase; acts as both a ribosome-associated and free cytoplasmic antioxidant; self-associates to form a high-molecular weight chaperone complex under oxidative stress; deletion results in mutator phenotype; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress	protein folding|cellular response to oxidative stress|replicative cell aging|DNA protection|DNA damage checkpoint|cell redox homeostasis|response to hydroperoxide	unfolded protein binding|ribosome binding|peroxiredoxin activity|thioredoxin peroxidase activity	cytosol|polysome|cytoplasm
YBR273C	YBR273C	UBX7	hom	Verified	1.40706586036453	0.0797039301406794	no	467	0.0589982968291009	288	NA	FT	PROTEOLYSIS	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM		UBX (ubiquitin regulatory X) domain-containing protein; interacts with Cdc48p; UBX7 has a paralog, UBX6, that arose from the whole genome duplication	sporulation resulting in formation of a cellular spore|ubiquitin-dependent protein catabolic process	molecular_function	nuclear envelope|endoplasmic reticulum
YEL016C	YEL016C	NPP2	hom	Verified	1.40582195402272	0.0798885005993404	no	468	0.0840989928405903	286	NA	FT	NUCLEOTIDE METABOLISM			Nucleotide pyrophosphatase/phosphodiesterase; mediates extracellular nucleotide phosphate hydrolysis along with Npp1p and Pho5p; activity and expression enhanced during conditions of phosphate starvation; NPP2 has a paralog, NPP1, that arose from the whole genome duplication	nucleoside triphosphate metabolic process	nucleotide diphosphatase activity|nucleoside-triphosphate diphosphatase activity|nucleoside-triphosphatase activity|phosphodiesterase I activity	cellular_component
YDR463W	YDR463W	STP1	hom	Verified	1.40542713289421	0.0799471515695706	no	469	0.160050535145386	498	NA	FT	TRANSCRIPTION FROM RNA POL II|RNA PROCESSING	NUCLEUS|PLASMA MEMBRANE		Transcription factor; undergoes proteolytic processing by SPS (Ssy1p-Ptr3p-Ssy5p)-sensor component Ssy5p in response to extracellular amino acids; activates transcription of amino acid permease genes and may have a role in tRNA processing; STP1 has a paralog, STP2, that arose from the whole genome duplication	positive regulation of transcription, DNA-dependent|tRNA splicing, via endonucleolytic cleavage and ligation|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	plasma membrane|nucleus|cytoplasm
YHR012W	YHR012W	VPS29	hom	Verified	1.40465540817173	0.0800618858574025	no	470	0.0991656972646089	451	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM		Endosomal protein that is a subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde transport; forms a subcomplex with Vps35p and Vps26p that selects cargo proteins for endosome-to-Golgi retrieval	retrograde transport, endosome to Golgi	protein transporter activity	endosome|retromer complex, inner shell|retromer complex
YDL130W	YDL130W	RPP1B	hom	Verified	1.40339513593944	0.0802495213258211	no	471	0.0959402215983893	355	NA	FT	TRANSLATION		RIBOSOME	Ribosomal protein P1 beta, component of the ribosomal stalk, which is involved in interaction of translational elongation factors with ribosome; accumulation is regulated by phosphorylation and interaction with the P2 stalk component	cytoplasmic translation|translational elongation	structural constituent of ribosome	cytosolic large ribosomal subunit
YNL339C	YNL339C	YRF1-6	hom	Verified	1.40268661929959	0.0803551545748353	no	472	0.0636056527357181	270	NA	FT		NUCLEUS		Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p	telomere maintenance via recombination	DNA helicase activity	nucleus
YGL037C	YGL037C	PNC1	hom	Verified	1.40197788234367	0.0804609257532639	no	473	0.0595045431016988	243	NA	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|GENE SILENCING	NUCLEUS		Nicotinamidase that converts nicotinamide to nicotinic acid; part of the NAD(+) salvage pathway; required for life span extension by calorie restriction; PNC1 expression responds to all known stimuli that extend replicative life span; protein increases in abundance and relative distribution to cytoplasmic foci decreases upon DNA replication stress	replicative cell aging|chromatin silencing at rDNA|nicotinate nucleotide salvage|chromatin silencing at telomere	nicotinamidase activity	nucleus|peroxisome|cytoplasm
YBL024W	YBL024W	NCL1	hom	Verified	1.40132326001334	0.080558714332803	no	474	0.115027759526614	388	NA	FT	RNA PROCESSING	NUCLEUS		S-adenosyl-L-methionine-dependent tRNA: m5C-methyltransferase, methylates cytosine to m5C at several positions in tRNAs and intron-containing pre-tRNAs; increases proportion of tRNALeu(CAA) with m5C at wobble position in response to hydrogen peroxide, causing selective translation of mRNA from genes enriched in TTG codon; loss of NCL1 confers hypersensitivity to oxidative stress; similar to Nop2p and human proliferation associated nucleolar protein p120	tRNA methylation	tRNA (cytosine-5-)-methyltransferase activity	nucleus
YFR039C_p	YFR039C	YFR039C	hom	Uncharacterized	1.40122710038422	0.0805730863780247	no	475	0.0613615591062954	255	NA					Putative protein of unknown function; may be involved in response to high salt and changes in carbon source; deletion mutant has decreased spore survival in Drosophila feces	biological_process	molecular_function	cellular_component
YKR102W	YKR102W	FLO10	hom	Verified	1.39733759093113	0.0811560383798206	no	476	0.0619869348681338	212	NA					Member of the FLO family of cell wall flocculation proteins; not expressed in most lab strains; overproduction induces flocculation that can be inhibited by mannose, sucrose, or glucose; overproduction also promotes haploid invasive growth and diploid filamentous growth	filamentous growth of a population of unicellular organisms|flocculation via cell wall protein-carbohydrate interaction|flocculation|invasive growth in response to glucose limitation	mannose binding	fungal-type cell wall
YCL045C	YCL045C	EMC1	hom	Verified	1.39633967087167	0.0813061164457491	no	477	0.0778744183999135	352	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Member of conserved endoplasmic reticulum membrane complex; involved in efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; interacts with Gal80p; homologous to worm H17B01.4/EMC-1, fly CG2943, and human KIAA0090	protein folding in endoplasmic reticulum	molecular_function	ER membrane protein complex|endoplasmic reticulum
YKL073W	YKL073W	LHS1	hom	Verified	1.39356559686136	0.0817244117385587	no	478	0.104740883081863	435	NA	FT	PROTEIN LOCALIZATION|NUCLEOTIDE METABOLISM	ENDOPLASMIC RETICULUM		Molecular chaperone of the endoplasmic reticulum lumen, involved in polypeptide translocation and folding; nucleotide exchange factor for the ER lumenal Hsp70 chaperone Kar2p; regulated by the unfolded protein response pathway	posttranslational protein targeting to membrane, translocation|response to unfolded protein	unfolded protein binding|adenyl-nucleotide exchange factor activity|ATP binding	endoplasmic reticulum lumen
YHR094C	YHR094C	HXT1	hom	Verified	1.39138353018673	0.0820545781058205	no	479	0.0801856031482011	336	NA	FT		PLASMA MEMBRANE		Low-affinity glucose transporter of the major facilitator superfamily, expression is induced by Hxk2p in the presence of glucose and repressed by Rgt1p when glucose is limiting; HXT1 has a paralog, HXT6, what arose from the whole genome duplication	mannose transport|glucose transport	galactose transmembrane transporter activity|pentose transmembrane transporter activity|mannose transmembrane transporter activity|glucose transmembrane transporter activity|fructose transmembrane transporter activity	integral to membrane|plasma membrane
YMR085W_p	YMR085W	YMR085W	hom	Uncharacterized	1.39092317624745	0.0821243620024471	no	480	0.0873829110486618	373	NA	FT	CARBOHYDRATE METABOLISM			Putative protein of unknown function; YMR085W and adjacent ORF YMR084W are merged in related strains, and together are paralogous to glutamine-fructose-6-phosphate amidotransferase GFA1	biological_process	molecular_function	cellular_component
YGR121W-A_p	YGR121W-A	YGR121W-A	hom	Uncharacterized	1.39084664369821	0.082135967712017	no	481	0.0757024187967789	296	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YJL078C	YJL078C	PRY3	hom	Verified	1.3900784663638	0.0822525257165326	no	482	0.0563957084352602	249	NA					Cell wall-associated protein involved in export of acetylated sterols; member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis related 1 proteins); role in mating efficiency; expression of full-length transcript is daughter cell-specific; in response to alpha factor, a short transcript starting at +452 is expressed and the long form is repressed by Ste12p	biological_process	molecular_function	fungal-type cell wall
YDR036C	YDR036C	EHD3	hom	Verified	1.38812443401187	0.0825495787196247	no	483	0.0629160693886826	267	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		3-hydroxyisobutyryl-CoA hydrolase, member of a family of enoyl-CoA hydratase/isomerases; non-tagged protein is detected in highly purified mitochondria in high-throughput studies; phosphorylated; mutation affects fluid-phase endocytosis	fatty acid beta-oxidation|biological_process	3-hydroxyisobutyryl-CoA hydrolase activity	mitochondrion
YML016C	YML016C	PPZ1	hom	Verified	1.38456374536983	0.0830929518400548	no	484	0.100785035950532	341	NA	FT	PROTEIN LOCALIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS	NUCLEUS|PLASMA MEMBRANE		Serine/threonine protein phosphatase Z, isoform of Ppz2p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance	cellular sodium ion homeostasis|cellular protein localization|protein dephosphorylation	protein serine/threonine phosphatase activity	extrinsic to plasma membrane|nucleus|cytoplasm
YBR188C	YBR188C	NTC20	hom	Verified	1.38278898957075	0.0833647880067069	no	485	0.073527691261433	295	NA	FT	RNA PROCESSING	NUCLEUS		Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs	mRNA splicing, via spliceosome	first spliceosomal transesterification activity	Prp19 complex|U2-type catalytic step 1 spliceosome
YBR078W	YBR078W	ECM33	hom	Verified	1.38273682438087	0.0833727881563775	no	486	0.156428353417487	538	NA	FF|FT	CELL WALL ORG/BIOGENESIS	MITOCHONDRION|PLASMA MEMBRANE		GPI-anchored protein of unknown function, has a possible role in apical bud growth; GPI-anchoring on the plasma membrane crucial to function; phosphorylated in mitochondria; similar to Sps2p and Pst1p	fungal-type cell wall organization	molecular_function	mitochondrion|fungal-type cell wall|plasma membrane
YDL155W	YDL155W	CLB3	hom	Verified	1.38195191481898	0.0834932330116334	no	487	0.0808315141335536	300	NA	FT	CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION	NUCLEUS		B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation; relative distribution to the nucleus increases upon DNA replication stress	G2/M transition of mitotic cell cycle|S phase of mitotic cell cycle|regulation of cyclin-dependent protein kinase activity|positive regulation of spindle pole body separation	cyclin-dependent protein kinase regulator activity	nucleus|cytoplasm
YIL141W_d	YIL141W	YIL141W	hom	Dubious	1.37935161730137	0.0838931844836745	no	488	0.0798621101042851	343	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YLR412W	YLR412W	BER1	hom	Verified	1.37892675224226	0.083958669452886	no	489	0.0775116833571923	325	NA	FT		CYTOSKELETON		Protein involved in microtubule-related processes, N-acetylation; GFP-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YLR412W is not an essential gene; similar to Arabidopsis SRR1 gene	biological_process	molecular_function	cytoplasm
YLR312C_p	YLR312C	YLR312C	hom	Uncharacterized	1.37852984710495	0.0840198795960556	no	490	0.0841785871077181	318	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YPR028W	YPR028W	YOP1	hom	Verified	1.37844772555131	0.0840325484471511	no	491	0.0845172054214574	364	NA	FT	VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Membrane protein that interacts with Yip1p to mediate membrane traffic; interacts with Sey1p to maintain ER morphology; overexpression leads to cell death and accumulation of internal cell membranes; mutants have reduced phosphatidylserine transfer between the ER and mitochondria; forms ER foci upon DNA replication stress	vesicle-mediated transport|endoplasmic reticulum organization|endoplasmic reticulum inheritance|nuclear pore complex assembly	protein binding	integral to membrane|endoplasmic reticulum|endoplasmic reticulum tubular network
YKR033C_d	YKR033C	YKR033C	hom	Dubious	1.37263731575618	0.0849325626001506	no	492	0.0853161587594106	295	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene DAL80	Unknown	Unknown	Unknown
YLR373C	YLR373C	VID22	hom	Verified	1.3702185114031	0.0853093507333322	no	493	0.101285495189039	440	NA	FT	PROTEIN LOCALIZATION	NUCLEUS|PLASMA MEMBRANE		Glycosylated integral membrane protein localized to the plasma membrane; plays a role in fructose-1,6-bisphosphatase (FBPase) degradation; involved in FBPase transport from the cytosol to Vid (vacuole import and degradation) vesicles	vacuolar protein catabolic process	molecular_function	integral to plasma membrane
YNL176C_p	YNL176C	TDA7	hom	Uncharacterized	1.36522006437551	0.0860919469665669	no	494	0.0850408456730681	309	NA					Cell cycle-regulated gene of unknown function, promoter bound by Fkh2p; null mutant is sensitive to expression of the top1-T722A allele	biological_process	molecular_function	fungal-type vacuole
YBL087C	YBL087C	RPL23A	hom	Verified	1.36508112666374	0.0861137766159497	no	495	0.0880788576396471	312	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L23A; homologous to mammalian ribosomal protein L23 and bacterial L14; RPL23A has a paralog, RPL23B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YPR133W-A	YPR133W-A	TOM5	hom	Verified	1.36162097935666	0.0866587654408871	no	496	0.0799256079292177	327	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import of all mitochondrially directed proteins; involved in transfer of precursors from the Tom70p and Tom20p receptors to the Tom40p pore	mitochondrial outer membrane translocase complex assembly|protein targeting to mitochondrion	protein channel activity	mitochondrial outer membrane|mitochondrion|integral to membrane|integral to mitochondrial outer membrane|mitochondrial outer membrane translocase complex
YFL001W	YFL001W	DEG1	hom	Verified	1.36080805389313	0.086787178030285	no	497	0.114520718233772	374	NA	FT	RNA PROCESSING	NUCLEUS		tRNA:pseudouridine synthase, introduces pseudouridines at position 38 or 39 in tRNA, important for maintenance of translation efficiency and normal cell growth, localizes to both the nucleus and cytoplasm; non-essential for viability	tRNA pseudouridine synthesis	pseudouridine synthase activity	nucleus|cytoplasm
YKL220C	YKL220C	FRE2	hom	Verified	1.35767456092988	0.0872834861642448	no	498	0.0631155392633586	252	NA	FT	ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|GEN. OF PRECURSOR METABOLITES AND ENERGY	PLASMA MEMBRANE		Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low iron levels but not by low copper levels	iron ion transport|copper ion import	ferric-chelate reductase activity	integral to membrane|plasma membrane
YDR153C	YDR153C	ENT5	hom	Verified	1.35187635578147	0.0882074362562801	no	499	0.0727191536443501	243	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM		Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p, clathrin adaptor complex AP-1, and clathrin	late endosome to vacuole transport via multivesicular body sorting pathway|early endosome to Golgi transport|Golgi to endosome transport	clathrin binding|phosphatidylinositol-3,5-bisphosphate binding	endosome|clathrin vesicle coat|cytoplasm
YPR078C_p	YPR078C	YPR078C	hom	Uncharacterized	1.35062625134186	0.0884075936161192	no	500	0.069422048459614	329	NA					Putative protein of unknown function; possible role in DNA metabolism and/or in genome stability; expression is heat-inducible	biological_process	molecular_function	cellular_component
YHL046C	YHL046C	PAU13	hom	Verified	1.34995392104081	0.0885153819640619	no	501	0.0699514079671551	300	NA					Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions; expression is induced after ethanol shock	biological_process	molecular_function	cellular_component
YGL027C	YGL027C	CWH41	hom	Verified	1.34723715062979	0.0889519332508507	no	502	0.111460000100028	394	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Processing alpha glucosidase I, ER type II integral membrane N-glycoprotein involved in assembly of cell wall beta 1,6 glucan and asparagine-linked protein glycosylation; also involved in ER protein quality control and sensing of ER stress	fungal-type cell wall biogenesis|protein N-linked glycosylation	mannosyl-oligosaccharide glucosidase activity	endoplasmic reticulum membrane
YNL109W_d	YNL109W	YNL109W	hom	Dubious	1.34695546772805	0.0889972877423626	no	503	0.0922271558570048	359	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YNL108C	Unknown	Unknown	Unknown
YML057W	YML057W	CMP2	hom	Verified	1.34439907959545	0.0894096856509039	no	504	0.060834095241442	248	NA	FT	SIGNALING|ION HOMEOSTASIS|ION HOMEOSTASIS			Calcineurin A; one isoform (the other is CNA1) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1	adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion|cellular ion homeostasis	calcium-dependent protein serine/threonine phosphatase activity	calcineurin complex|cytoplasm
YEL023C_p	YEL023C	YEL023C	hom	Uncharacterized	1.34388773887432	0.0894923457381473	no	505	0.0903559739101227	335	NA					Putative protein of unknown function; expression is increased greatly during sporulation; YEL023C is not an essential gene	biological_process	molecular_function	cellular_component
YCL035C	YCL035C	GRX1	hom	Verified	1.34142480830576	0.0898912837089354	no	506	0.0752683682682567	276	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		Glutathione-dependent disulfide oxidoreductase; hydroperoxide and superoxide-radical responsive, heat-stable, with active site cysteine pair; protects cells from oxidative damage; GRX1 has a paralog, GRX2, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress	protein glutathionylation|cellular response to oxidative stress	disulfide oxidoreductase activity|glutathione transferase activity|glutathione peroxidase activity	nucleus|cytoplasm
YOL137W	YOL137W	BSC6	hom	Verified	1.33804163390689	0.0904414326332248	no	507	0.0969422405643261	358	NA	FT		GOLGI APPARATUS		Protein of unknown function containing 8 putative transmembrane seqments; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression	biological_process	molecular_function	COPI-coated vesicle|integral to membrane|clathrin-coated vesicle
YJL077W-B_p	YJL077W-B	YJL077W-B	hom	Uncharacterized	1.33127088393608	0.0915499474913429	no	508	0.127342286259122	401	NA					Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching	biological_process	molecular_function	cellular_component
YER050C	YER050C	RSM18	hom	Verified	1.32850972238893	0.0920048869364092	no	509	0.12885779255204	439	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YOR104W	YOR104W	PIN2	hom	Verified	1.32507621740688	0.092572936643222	no	510	0.101045112129875	405	NA					Protein that induces appearance of [PIN+] prion when overproduced; predicted to be palmitoylated	biological_process	molecular_function	cellular_component
YKL072W	YKL072W	STB6	hom	Verified	1.32101963146051	0.0932474092587164	no	511	0.0597019935283448	221	NA					Protein that binds Sin3p in a two-hybrid assay	biological_process	molecular_function	cellular_component
YLR364W	YLR364W	GRX8	hom	Verified	1.32098977078457	0.093252387502552	no	512	0.0670918064146811	278	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY			Glutaredoxin that employs a dithiol mechanism of catalysis; monomeric; activity is low and null mutation does not affect sensitivity to oxidative stress; GFP-fusion protein localizes to the cytoplasm; expression strongly induced by arsenic	biological_process	glutathione-disulfide reductase activity	cytoplasm
YCR014C	YCR014C	POL4	hom	Verified	1.31888113675968	0.0936044266692733	no	513	0.0897541840983856	354	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		DNA polymerase IV, undergoes pair-wise interactions with Dnl4p-Lif1p and Rad27p to mediate repair of DNA double-strand breaks by non-homologous end joining (NHEJ); homologous to mammalian DNA polymerase beta	double-strand break repair|base-excision repair, gap-filling|double-strand break repair via nonhomologous end joining	DNA-directed DNA polymerase activity	nucleus
YPL058C	YPL058C	PDR12	hom	Verified	1.31875766605648	0.0936250706351502	no	514	0.0945181358445635	377	NA	FT	KETONE METABOLISM|NUCLEOTIDE METABOLISM	PLASMA MEMBRANE		Plasma membrane ATP-binding cassette (ABC) transporter, weak-acid-inducible multidrug transporter required for weak organic acid resistance; induced by sorbate and benzoate and regulated by War1p; mutants exhibit sorbate hypersensitivity	propionate metabolic process|transport|organic acid transport	xenobiotic-transporting ATPase activity|organic acid transmembrane transporter activity	integral to membrane|plasma membrane
YMR142C	YMR142C	RPL13B	hom	Verified	1.31830423226362	0.0937009123757465	no	515	0.105767159238532	415	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L13B; not essential for viability; homologous to mammalian ribosomal protein L13, no bacterial homolog; RPL13B has a paralog, RPL13A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YDR389W	YDR389W	SAC7	hom	Verified	1.31825756060949	0.0937087212921408	no	516	0.155346160593029	561	NA	FF|FT	CELL CYCLE|SIGNALING|CYTOSKELETON ORGANIZATION	CYTOSKELETON		GTPase activating protein (GAP) for Rho1p, involved in signaling to the actin cytoskeleton, null mutations suppress tor2 mutations and temperature sensitive mutations in actin; potential Cdc28p substrate	actin filament reorganization involved in cell cycle|small GTPase mediated signal transduction	Rho GTPase activator activity	intracellular
YJR133W	YJR133W	XPT1	hom	Verified	1.318171792566	0.0937230729143802	no	517	0.0898123462246607	316	NA	FT	NUCLEOTIDE METABOLISM			Xanthine-guanine phosphoribosyl transferase, required for xanthine utilization and for optimal utilization of guanine	XMP salvage|hypoxanthine metabolic process	xanthine phosphoribosyltransferase activity|hypoxanthine phosphoribosyltransferase activity	cytoplasm
YOR022C_p	YOR022C	YOR022C	hom	Uncharacterized	1.31697698573035	0.0939231695009054	no	518	0.0847874192512881	357	NA	FT	LIPID METABOLISM	MITOCHONDRION		Putative carboxylic ester hydrolase; similar to bovine phospholipase A1; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	phospholipase activity	mitochondrion
YBL021C	YBL021C	HAP3	hom	Verified	1.31337245794496	0.0945287367615733	no	519	0.100499660686506	302	NA	FT	TRANSCRIPTION FROM RNA POL II|OXIDATION-REDUCTION PROCESS|RESPONSE TO NUTRIENT LEVELS|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS		Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences contributing to both complex assembly and DNA binding	carbon catabolite activation of transcription from RNA polymerase II promoter|regulation of cellular respiration	RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	CCAAT-binding factor complex
YDL011C_d	YDL011C	YDL011C	hom	Dubious	1.31115457518422	0.0949027728009515	no	520	0.0836715446580088	301	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the uncharacterized ORF YDL010W	Unknown	Unknown	Unknown
YKR015C_p	YKR015C	YKR015C	hom	Uncharacterized	1.30909905024668	0.095250400472821	no	521	0.0715559691214112	287	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YGL094C	YGL094C	PAN2	hom	Verified	1.30701345490763	0.0956040709568282	no	522	0.106466882989397	384	NA	FT	RNA PROCESSING|RESPONSE TO DNA DAMAGE|PROTEOLYSIS			Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes	mRNA 3'-end processing|postreplication repair|mRNA processing	poly(A)-specific ribonuclease activity	PAN complex|cytoplasm
YIL054W_p	YIL054W	YIL054W	hom	Uncharacterized	1.30553155088564	0.0958559554562423	no	523	0.0984604789821716	396	NA					Protein of unknown function; expressed at both mRNA and protein levels	biological_process	molecular_function	cellular_component
YJR144W	YJR144W	MGM101	hom	Verified	1.3038908629521	0.0961353980223152	no	524	0.12322436087431	493	NA	FT	RESPONSE TO DNA DAMAGE|MITOCHONDRION ORGANIZATION	MITOCHONDRION|CHROMOSOME		Protein with a role in mitochondrial DNA recombinational repair;also involved in interstrand cross-link repair; binds to and catalyzes the annealing of single-stranded mtDNA; oligomerizes to form rings and filaments; related to Rad52-type recombination proteins, with limited overall similarity but sharing conserved functionally important residues; component of the mitochondrial nucleoid, required for the repair of oxidative mtDNA damage	DNA repair|recombinational repair|DNA strand renaturation	molecular_function	mitochondrial nucleoid|mitochondrion
YDR530C	YDR530C	APA2	hom	Verified	1.30062680846901	0.0966931130596632	no	525	0.0521958196596587	206	NA	FT	NUCLEOTIDE METABOLISM	NUCLEUS		Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase II; AP4A phosphorylase involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; APA2 has a paralog, APA1, that arose from the whole genome duplication	nucleoside catabolic process	bis(5'-nucleosyl)-tetraphosphatase activity	nucleus|cytoplasm
YHR129C	YHR129C	ARP1	hom	Verified	1.29637108003378	0.0974238353267072	no	526	0.0822536016069154	420	NA	FT	CELL CYCLE|CYTOSKELETON ORGANIZATION	CYTOSKELETON		Actin-related protein of the dynactin complex; required for spindle orientation and nuclear migration; putative ortholog of mammalian centractin	nuclear migration|establishment of mitotic spindle orientation	structural constituent of cytoskeleton	cell cortex|dynactin complex|spindle pole body|astral microtubule
YPL158C	YPL158C	AIM44	hom	Verified	1.29440364786256	0.0977630156421417	no	527	0.133440800026098	465	NA	FT		SITE OF POLARIZED GROWTH		Protein of unknown function; GFP-fusion protein localizes to the bud neck; transcription is regulated by Swi5p; null mutant displays elevated frequency of mitochondrial genome loss; relocalizes from bud neck to cytoplasm upon DNA replication stress	biological_process	molecular_function	cellular bud neck
YGL012W	YGL012W	ERG4	hom	Verified	1.29438129517743	0.0977668741555645	no	528	0.217332181538694	797	NA	FF|FT	LIPID METABOLISM|OXIDATION-REDUCTION PROCESS	ENDOPLASMIC RETICULUM		C-24(28) sterol reductase, catalyzes the final step in ergosterol biosynthesis; mutants are viable, but lack ergosterol	ergosterol biosynthetic process	delta24(24-1) sterol reductase activity	integral to membrane|endoplasmic reticulum
YGL219C	YGL219C	MDM34	hom	Verified	1.2943143661822	0.0977784280850961	no	529	0.131598533337642	444	NA	FT	MITOCHONDRION ORGANIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION		Mitochondrial component of the ERMES complex that links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth	mitochondrion organization|phospholipid transport	molecular_function	mitochondrial outer membrane|ERMES complex|mitochondrion|cytoplasm
YPR174C	YPR174C	YPR174C	hom	Verified	1.2935394082928	0.097912281700509	no	530	0.0898396167157947	315	NA	FT		ENDOMEMBRANE SYSTEM|NUCLEUS|CYTOSKELETON		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nuclear periphery; potential Cdc28p substrate; binds phosphatidylinositols and phosphatidylethanolamine in a large-scale study; relative distribution to foci at the nuclear periphery increases upon DNA replication stress; YPR174C has a paralog, NBP1, that arose from the whole genome duplication	biological_process	molecular_function	nuclear envelope|spindle pole body
YHR204W	YHR204W	MNL1	hom	Verified	1.29271334823142	0.0980551096928145	no	531	0.0922127188321417	426	NA	FT	PROTEOLYSIS	ENDOPLASMIC RETICULUM		Alpha-1,2-specific exomannosidase of the endoplasmic reticulum; in complex with Pdi1p, generates a Man7GlcNac2 oligosaccharide signal on glycoproteins destined for ubiquitin-proteasome degradation	ER-associated protein catabolic process	carbohydrate binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	endoplasmic reticulum lumen
YOL059W	YOL059W	GPD2	hom	Verified	1.29123226464858	0.0983115751308674	no	532	0.131182506206715	454	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM	MITOCHONDRION		NAD-dependent glycerol 3-phosphate dehydrogenase, homolog of Gpd1p, expression is controlled by an oxygen-independent signaling pathway required to regulate metabolism under anoxic conditions; located in cytosol and mitochondria; constitutively active but is inactivated via phosphorylation by energy-stress responsive kinase SNF1	NADH oxidation|glycerol metabolic process	glycerol-3-phosphate dehydrogenase [NAD+] activity	cytosol|mitochondrion
YBR137W	YBR137W	YBR137W	hom	Verified	1.29087145176028	0.0983741280890667	no	533	0.0744622253553816	329	NA					Protein of unknown function; localized to the cytoplasm; binds to Replication Protein A (RPA); also interacts with Sgt2p; YBR137W is not an essential gene	biological_process	molecular_function	TRC complex|cytoplasm
YDR155C	YDR155C	CPR1	hom	Verified	1.29000956319639	0.0985236688676072	no	534	0.0903223129928277	424	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|CHROMATIN ORGANIZATION	NUCLEUS|MITOCHONDRION|CHROMOSOME		Cytoplasmic peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds the drug cyclosporin A; protein abundance increases in response to DNA replication stress	cellular protein metabolic process|ascospore formation|positive regulation of meiosis|histone deacetylation	peptidyl-prolyl cis-trans isomerase activity|cyclosporin A binding	histone deacetylase complex|mitochondrion|Set3 complex|nucleus
YDR105C	YDR105C	TMS1	hom	Verified	1.28917675514401	0.0986683221053073	no	535	0.106213705190156	369	NA					Vacuolar membrane protein of unknown function that is conserved in mammals; predicted to contain eleven transmembrane helices; interacts with Pdr5p, a protein involved in multidrug resistance	biological_process	molecular_function	fungal-type vacuole membrane|integral to membrane|membrane
YKL005C	YKL005C	BYE1	hom	Verified	1.28709881183955	0.0990299247702512	no	536	0.0870302042373213	343	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Negative regulator of transcription elongation, contains a TFIIS-like domain and a PHD finger, multicopy suppressor of temperature-sensitive ess1 mutations, probably binds RNA polymerase II large subunit	negative regulation of transcription from RNA polymerase II promoter	methylated histone residue binding	nucleus
YER015W	YER015W	FAA2	hom	Verified	1.28426845280222	0.0995240205252581	no	537	0.100902066391936	422	NA	FT	KETONE METABOLISM|LIPID METABOLISM	MITOCHONDRION		Medium chain fatty acyl-CoA synthetase, activates imported fatty acids; accepts a wide range of fatty acid chain lengths with a preference for medium chains, C9:0-C13:0; localized to the peroxisome	long-chain fatty acid metabolic process	long-chain fatty acid-CoA ligase activity|very long-chain fatty acid-CoA ligase activity|medium-chain fatty acid-CoA ligase activity	mitochondrion|peroxisome
YLR399C	YLR399C	BDF1	hom	Verified	1.28373982623214	0.0996165021917804	no	538	0.0910754033297988	426	NA	FT	CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING	NUCLEUS|CHROMOSOME		Protein involved in transcription initiation at TATA-containing promoters; associates with the basal transcription factor TFIID; contains two bromodomains; corresponds to the C-terminal region of mammalian TAF1; redundant with Bdf2p	DNA repair|snRNA transcription|regulation of chromatin silencing at telomere|regulation of transcription by chromatin organization|regulation of chromatin silencing at silent mating-type cassette|Unknown|chromatin remodeling|negative regulation of heterochromatin assembly	histone acetyl-lysine binding|chromatin binding|core promoter binding|TFIID-class transcription factor binding	nuclear chromatin|Swr1 complex
YDR007W	YDR007W	TRP1	hom	Verified	1.28333606424335	0.0996871814540973	no	539	0.262100260633791	962	NA	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM			Phosphoribosylanthranilate isomerase that catalyzes the third step in tryptophan biosynthesis; in 2004, the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA)	tryptophan biosynthetic process	phosphoribosylanthranilate isomerase activity	cytoplasm
YIL058W_d	YIL058W	YIL058W	hom	Dubious	1.28295341012921	0.0997541995551159	no	540	0.104588633564455	369	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YGR108W	YGR108W	CLB1	hom	Verified	1.28161422163967	0.0999890044013003	no	541	0.0875935858355326	363	NA	FT	CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION	NUCLEUS		B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome	G2/M transition of mitotic cell cycle|meiotic G2/MI transition|regulation of cyclin-dependent protein kinase activity|mitotic spindle organization in nucleus|positive regulation of spindle pole body separation	cyclin-dependent protein kinase regulator activity	cyclin-dependent protein kinase holoenzyme complex|nucleus|cytoplasm
YJR051W	YJR051W	OSM1	hom	Verified	1.28140707236566	0.100025360659805	no	542	0.0905408678025493	355	NA	FT	OXIDATION-REDUCTION PROCESS	MITOCHONDRION		Fumarate reductase, catalyzes the reduction of fumarate to succinate; required for the reoxidation of intracellular NADH under anaerobic conditions; mutations cause osmotic sensitivity; OSM1 has a paralog, FRD1, that arose from the whole genome duplication	cellular response to anoxia	fumarate reductase (NADH) activity	mitochondrion
YER038W-A_d	YER038W-A	YER038W-A	hom	Dubious	1.27798249757309	0.100627798808223	no	543	0.10543935693476	356	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 99% of ORF overlaps the verified gene HVG1; protein product detected in mitochondria	Unknown	Unknown	Unknown
YDR370C	YDR370C	DXO1	hom	Verified	1.27727748081465	0.100752150510381	no	544	0.0945683163511485	361	NA					Protein with decapping and 5&#8242;-3&#8242; exoRNase activity; similar to Rai1p	biological_process	molecular_function	cytoplasm
YLR402W_d	YLR402W	YLR402W	hom	Dubious	1.27617133720236	0.100947479236196	no	545	0.11348147530556	379	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YGL139W	YGL139W	FLC3	hom	Verified	1.2759924696673	0.100979090530133	no	546	0.0843158907831079	283	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION		Putative FAD transporter, similar to Flc1p and Flc2p; localized to the ER	FAD transport|transmembrane transport	FAD transmembrane transporter activity	mitochondrion|integral to membrane|endoplasmic reticulum
YJL070C_p	YJL070C	YJL070C	hom	Uncharacterized	1.27522844829632	0.101114197417276	no	547	0.0653747344806514	276	NA	FT	NUCLEOTIDE METABOLISM	MITOCHONDRION		Putative metallo-dependent hydrolase superfamily protein; similar to AMP deaminases but lacks key catalytic residues and does not rescue purine nucleotide metabolic defect of quadruple aah1 ade8 amd1 his1 mutant; may regulate purine nucleotide homeostasis as overexpression in an AMD1 strain grown in adenine results in greatly reduced GDP and GTP intracellular levels; not an essential gene; YJL070C has a paralog, YBR284W, that arose from the whole genome duplication	biological_process	AMP deaminase activity|molecular_function	mitochondrion|cytoplasm
YLL002W	YLL002W	RTT109	hom	Verified	1.27449209054687	0.101244536997581	no	548	0.108165056284147	407	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE	NUCLEUS		Histone acetyltransferase critical for cell survival in the presence of DNA damage during S phase; acetylates H3-K56 and H3-K9; involved in non-homologous end joining and in regulation of Ty1 transposition; interacts physically with Vps75p	negative regulation of transposition, RNA-mediated|histone acetylation|double-strand break repair via nonhomologous end joining|response to DNA damage stimulus|regulation of transcription from RNA polymerase II promoter in response to stress	H3 histone acetyltransferase activity	nucleus
YNL257C	YNL257C	SIP3	hom	Verified	1.27388835125386	0.101351493644932	no	549	0.126524175076386	477	NA	FT	TRANSCRIPTION FROM RNA POL II			Transcription cofactor; acts through interaction with DNA-bound Snf1p; C-terminal region has a putative leucine zipper motif; potential Cdc28p substrate; SIP3 has a paralog, YSP1, that arose from the whole genome duplication	positive regulation of transcription from RNA polymerase II promoter	transcription cofactor activity	integral to membrane
YDL057W_p	YDL057W	YDL057W	hom	Uncharacterized	1.27351249627825	0.101418120548372	no	550	0.0777824692290088	323	NA					Putative protein of unknown function; YDL057W is not an essential gene	biological_process	molecular_function	cellular_component
YIL006W	YIL006W	YIA6	hom	Verified	1.27323806380608	0.101466788678051	no	551	0.111438713369623	393	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Mitochondrial NAD+ transporter, involved in the transport of NAD+ into the mitochondria (see also YEA6); member of the mitochondrial carrier subfamily; disputed role as a pyruvate transporter; has putative mouse and human orthologs	transport|mitochondrial pyruvate transport|NAD transmembrane transport	pyruvate secondary active transmembrane transporter activity|transporter activity|NAD transporter activity	mitochondrion|integral to membrane|mitochondrial inner membrane
YOR277C_d	YOR277C	YOR277C	hom	Dubious	1.27092718933648	0.101877276306257	no	552	0.121661083865991	453	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the verified gene CAF20	Unknown	Unknown	Unknown
YFL007W	YFL007W	BLM10	hom	Verified	1.2696193957304	0.102110118540439	no	553	0.10185720523853	397	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS	NUCLEUS		Proteasome activator; binds the core proteasome and stimulates proteasome-mediated protein degradation by inducing gate opening; required for resistance to bleomycin, may be involved in protecting against oxidative damage; similar to mammalian PA200	proteasome assembly|regulation of proteasomal protein catabolic process	proteasome binding|peptidase activator activity	proteasome core complex|proteasome complex|integral to membrane|nucleus
YOL009C	YOL009C	MDM12	hom	Verified	1.26943551793272	0.10214288753825	no	554	0.0993341002445604	429	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION		Mitochondrial outer membrane protein, required for transmission of mitochondria to daughter cells; component of the ERMES complex that links the ER to mitochondria; may influence import and assembly of outer membrane beta-barrel proteins	mitochondrion inheritance|mitochondrion organization|protein import into mitochondrial outer membrane|phospholipid transport	molecular_function	mitochondrial outer membrane|mitochondrion|ERMES complex
YGR031W	YGR031W	IMO32	hom	Verified	1.26735321356639	0.102514510527701	no	555	0.0861957059363299	346	NA	FT		MITOCHONDRION		Conserved mitochondrial protein of unknown function; processed by both mitochondrial processing peptidase and mitochondrial octapeptidyl aminopeptidase; gene contains the nested antisense gene NAG1	biological_process	molecular_function	mitochondrion
YKR042W	YKR042W	UTH1	hom	Verified	1.26588373316296	0.102777355524558	no	556	0.0926319598708533	426	NA	FT	CELL CYCLE|CHROMATIN ORGANIZATION|CELL WALL ORG/BIOGENESIS|CELL DIVISION|GENE SILENCING	MITOCHONDRION		Protein involved in cell wall biogenesis; required for mitochondrial autophagy; mitochondrial outer membrane and cell wall localized SUN family member; involved in the oxidative stress response, life span during starvation, and cell death; UTH1 has a paralog, NCA3, that arose from the whole genome duplication	mitochondrion degradation|fungal-type cell wall biogenesis|negative regulation of chromatin silencing involved in replicative cell aging	molecular_function	mitochondrial outer membrane|fungal-type cell wall
YLR304C	YLR304C	ACO1	hom	Verified	1.26493167771438	0.102947910287666	no	557	0.157774101567082	592	NA	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Aconitase, required for the tricarboxylic acid (TCA) cycle and also independently required for mitochondrial genome maintenance; phosphorylated; component of the mitochondrial nucleoid; mutation leads to glutamate auxotrophy	propionate metabolic process|glutamate biosynthetic process|tricarboxylic acid cycle|mitochondrial genome maintenance|citrate metabolic process	double-stranded DNA binding|aconitate hydratase activity|single-stranded DNA binding	mitochondrial nucleoid|cytosol|mitochondrion|mitochondrial matrix
YML017W	YML017W	PSP2	hom	Verified	1.26105292624302	0.103644889549984	no	558	0.12556489890776	501	NA					Asn rich cytoplasmic protein that contains RGG motifs; high-copy suppressor of group II intron-splicing defects of a mutation in MRS2 and of a conditional mutation in POL1 (DNA polymerase alpha); possible role in mitochondrial mRNA splicing	biological_process	molecular_function	cytoplasm
YHL005C_d	YHL005C	YHL005C	hom	Dubious	1.25753764093438	0.10427950893952	no	559	0.0862461638578885	354	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YHL004W	Unknown	Unknown	Unknown
YLR361C-A_p	YLR361C-A	YLR361C-A	hom	Uncharacterized	1.25645024344219	0.104476387502775	no	560	0.0849309426767741	351	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YNL326C	YNL326C	PFA3	hom	Verified	1.2550756342757	0.104725652346357	no	561	0.113591725764744	434	NA	FT	MEMBRANE ORGANIZATION			Palmitoyltransferase for Vac8p, required for vacuolar membrane fusion; contains an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; autoacylates; required for vacuolar integrity under stress conditions	vacuole fusion, non-autophagic|protein palmitoylation	palmitoyltransferase activity	fungal-type vacuole membrane|integral to membrane|fungal-type vacuole
YNL032W	YNL032W	SIW14	hom	Verified	1.25485044390838	0.104766528280177	no	562	0.101451727828953	427	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION			Tyrosine phosphatase that plays a role in actin filament organization and endocytosis; localized to the cytoplasm	actin filament organization|endocytosis|protein dephosphorylation|response to stress	protein tyrosine phosphatase activity	cytoplasm
YHR015W	YHR015W	MIP6	hom	Verified	1.25337290190869	0.105035014247647	no	563	0.0895116673998938	344	NA	FT	RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	Putative RNA-binding protein; interacts with Mex67p, which is a component of the nuclear pore involved in nuclear mRNA export; MIP6 has a paralog, PES4, that arose from the whole genome duplication	mRNA export from nucleus	RNA binding	nuclear pore
YGR270W	YGR270W	YTA7	hom	Verified	1.25093920190633	0.105478329980221	no	564	0.153353507427836	509	NA	FT	TRANSCRIPTION FROM RNA POL II|GENE SILENCING	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM		Protein that localizes to chromatin and has a role in regulation of histone gene expression; has a bromodomain-like region that interacts with the N-terminal tail of histone H3, and an ATPase domain; potentially phosphorylated by Cdc28p	negative regulation of transcription from RNA polymerase II promoter|negative regulation of chromatin silencing|positive regulation of transcription from RNA polymerase II promoter	chromatin binding|histone binding	extrinsic to endoplasmic reticulum membrane|nucleus
YOR222W	YOR222W	ODC2	hom	Verified	1.24900645130601	0.105831357131407	no	565	0.0865332242000897	355	NA	FT		MITOCHONDRION		Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for use in lysine and glutamate biosynthesis and in lysine catabolism	mitochondrial transport	dicarboxylic acid transmembrane transporter activity	mitochondrion|integral to membrane|mitochondrial inner membrane
YNL085W	YNL085W	MKT1	hom	Verified	1.24841761982393	0.105939079864	no	566	0.100418697505074	418	NA	FT	RESPONSE TO DNA DAMAGE|TRANSLATION			Protein that forms a complex with Pbp1p; complex may mediate posttranscriptional regulation of HO; involved in propagation of M2 dsRNA satellite of L-A virus; allelic variation affects mitochondrial genome stability, drug resistance, and more; forms cytoplasmic foci upon DNA replication stress	positive regulation of translation|interspecies interaction between organisms|response to DNA damage stimulus	nuclease activity	polysome|cytoplasm
YPR001W	YPR001W	CIT3	hom	Verified	1.24830600031166	0.105959508828831	no	567	0.123362160092507	457	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Dual specificity mitochondrial citrate and methylcitrate synthase; catalyzes the condensation of acetyl-CoA and oxaloacetate to form citrate and that of propionyl-CoA and oxaloacetate to form 2-methylcitrate	propionate catabolic process, 2-methylcitrate cycle|propionate metabolic process|tricarboxylic acid cycle	2-methylcitrate synthase activity|citrate (Si)-synthase activity	mitochondrion
YML041C	YML041C	VPS71	hom	Verified	1.24733435126569	0.106137463447874	no	568	0.14943731890168	593	NA	FF|FT	PROTEIN LOCALIZATION|CHROMATIN ORGANIZATION|VACUOLAR TRANSPORT	NUCLEUS|CHROMOSOME		Nucleosome-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting	chromatin remodeling|protein targeting to vacuole|histone exchange	nucleosome binding	Swr1 complex|nucleus
YML048W	YML048W	GSF2	hom	Verified	1.24729359742233	0.106144932107454	no	569	0.141629072135568	550	NA	FF|FT	PROTEIN LOCALIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION		ER localized integral membrane protein that may promote secretion of certain hexose transporters, including Gal2p; involved in glucose-dependent repression	protein folding|protein localization to cell surface	unfolded protein binding	mitochondrial outer membrane|integral to endoplasmic reticulum membrane|cytoplasm
YLR297W	YLR297W	YLR297W	hom	Verified	1.24611202099262	0.106361636100512	no	570	0.0971327605779432	362	NA					Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; not an essential gene; induced by treatment with 8-methoxypsoralen and UVA irradiation; relocalizes from nucleus to vacuole upon DNA replication stress; YLR297W has a paralog, YOR186W, that arose from the whole genome duplication	biological_process	molecular_function	fungal-type vacuole
YGL198W	YGL198W	YIP4	hom	Verified	1.24242013761501	0.10704079474687	no	571	0.12053535608658	418	NA	FT		ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Protein that interacts with Rab GTPases, localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport	biological_process	Rab GTPase binding	integral to membrane|Golgi apparatus
YIL009W	YIL009W	FAA3	hom	Verified	1.24167059011121	0.107179062608865	no	572	0.109532879563768	417	NA	FT	KETONE METABOLISM|LIPID METABOLISM			Long chain fatty acyl-CoA synthetase, activates imported fatty acids; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery	long-chain fatty acid metabolic process	long-chain fatty acid-CoA ligase activity|very long-chain fatty acid-CoA ligase activity	cellular_component
YEL008W_d	YEL008W	YEL008W	hom	Dubious	1.23994159202262	0.107498499278279	no	573	0.0900930056461816	344	NA					Hypothetical protein predicted to be involved in metabolism	Unknown	Unknown	Unknown
YOR200W_d	YOR200W	YOR200W	hom	Dubious	1.23993437105704	0.107499834806718	no	574	0.158652940337895	584	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MRM1/YOR201c	Unknown	Unknown	Unknown
YGR137W_d	YGR137W	YGR137W	hom	Dubious	1.2388448981215	0.107701471488524	no	575	0.100038588439977	373	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YHR051W	YHR051W	COX6	hom	Verified	1.23883527399578	0.10770325390877	no	576	0.102757707211934	434	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Subunit VI of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; expression is regulated by oxygen levels	mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity	mitochondrion|integral to membrane|mitochondrial respiratory chain complex IV
YAR031W	YAR031W	PRM9	hom	Verified	1.23384216770919	0.108630861507241	no	577	0.113907168897379	379	NA	FT	VESICLE-MEDIATED TRANSPORT	ENDOPLASMIC RETICULUM|PLASMA MEMBRANE		Pheromone-regulated protein with 3 predicted transmembrane segments and an FF sequence, a motif involved in COPII binding; member of DUP240 gene family	vesicle organization	molecular_function	integral to membrane|endoplasmic reticulum|plasma membrane
YLR357W	YLR357W	RSC2	hom	Verified	1.23159339368187	0.109050504982691	no	578	0.113245577883535	428	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION	NUCLEUS	RSC COMPLEX	Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; involved in telomere maintenance	ATP-dependent chromatin remodeling|chromosome segregation|nucleosome disassembly|plasmid maintenance|sister chromatid cohesion|double-strand break repair via nonhomologous end joining|transcription elongation from RNA polymerase II promoter|double-strand break repair via homologous recombination	DNA translocase activity	RSC complex
YHR192W	YHR192W	LNP1	hom	Verified	1.23010599429827	0.109328707832597	no	579	0.15068064937857	550	NA					Lunapark family member involved in ER network formation; localizes to ER junctions and this localization is regulated by the yeast atlastin ortholog Sey1p; interacts with the reticulon protein Rtn1p; induced in response to the DNA-damaging agent MMS	endoplasmic reticulum tubular network organization	molecular_function	endoplasmic reticulum tubular network|cytoplasm
YDR443C	YDR443C	SSN2	hom	Verified	1.22956434174725	0.10943014493736	no	580	0.132508165625506	461	NA	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for stable association of Srb10p-Srb11p kinase; essential for transcriptional regulation	negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter by galactose	RNA polymerase II transcription coactivator activity|RNA polymerase II transcription factor recruiting transcription factor activity	mediator complex
YNL143C_p	YNL143C	YNL143C	hom	Uncharacterized	1.22929757372059	0.109480128324607	no	581	0.127876707444874	394	NA					Protein of unknown function; expressed at both mRNA and protein levels	biological_process	molecular_function	cellular_component
YML073C	YML073C	RPL6A	hom	Verified	1.22517777695567	0.110254122835003	no	582	0.109506721540709	394	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L6A; N-terminally acetylated; binds 5.8S rRNA; homologous to mammalian ribosomal protein L6, no bacterial homolog; RPL6A has a paralog, RPL6B, that arose from the whole genome duplication	cytoplasmic translation|ribosomal large subunit assembly	structural constituent of ribosome|RNA binding	cytosolic large ribosomal subunit
YJL118W	YJL118W	YJL118W	hom	Verified	1.22507359953848	0.110273745599992	no	583	0.0913169106142272	312	NA					Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; YJL18W is a non-essential gene; deletion enhances the toxicity of heterologously expressed human alpha-synuclein	biological_process	molecular_function	ribosome
YDR448W	YDR448W	ADA2	hom	Verified	1.22002905087921	0.111226931150022	no	584	0.171231221974528	607	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS	HISTONE ACETYLTRANSFERASE	Transcription coactivator, component of the ADA and SAGA transcriptional adaptor/HAT (histone acetyltransferase) complexes	chromatin silencing at rDNA|chromatin modification|regulation of transcription from RNA polymerase II promoter|positive regulation of histone acetylation|chromatin silencing at telomere	chromatin binding|transcription coactivator activity|histone acetyltransferase activity|phosphatidylserine binding	SLIK (SAGA-like) complex|Ada2/Gcn5/Ada3 transcription activator complex|SAGA complex
YJR142W_p	YJR142W	YJR142W	hom	Uncharacterized	1.21916365965502	0.111391040920172	no	585	0.103059682756438	434	NA					Putative protein of unknown function; GST fusion protein is a Dbf2p-Mob1p phosphorylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition; nudix hydrolase family member	biological_process	molecular_function	cellular_component
YLR171W_d	YLR171W	YLR171W	hom	Dubious	1.21913191442383	0.111397064268581	no	586	0.120599120304149	508	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YPR157W_p	YPR157W	TDA6	hom	Uncharacterized	1.21871330812038	0.111476512542908	no	587	0.117283125995094	426	NA	FT	PROTEIN LOCALIZATION			Putative protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation; null mutant is sensitive to expression of the top1-T722A allele	biological_process	molecular_function	cellular_component
YDR323C	YDR323C	PEP7	hom	Verified	1.2165394704819	0.111889742374627	no	588	0.1823024024727	664	NA	FF|FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT			Multivalent adaptor protein that facilitates vesicle-mediated vacuolar protein sorting by ensuring high-fidelity vesicle docking and fusion, which are essential for targeting of vesicles to the endosome; required for vacuole inheritance	Golgi to vacuole transport|vacuole inheritance|vesicle fusion|vesicle docking involved in exocytosis|Golgi to endosome transport	phosphatidylinositol-3-phosphate binding	external side of endosome membrane|cytoplasm
YLR139C	YLR139C	SLS1	hom	Verified	1.21582966178386	0.112024908492094	no	589	0.142713732976257	502	NA	FT	TRANSLATION|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Mitochondrial membrane protein that coordinates expression of mitochondrially-encoded genes; may facilitate delivery of mRNA to membrane-bound translation machinery	aerobic respiration|mitochondrial translation	molecular_function	mitochondrial nucleoid|mitochondrion|integral to membrane|mitochondrial inner membrane
YCR001W_d	YCR001W	YCR001W	hom	Dubious	1.21579021974229	0.112032422709297	no	590	0.0916353656219254	352	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR001W is not an essential gene	Unknown	Unknown	Unknown
YKL217W	YKL217W	JEN1	hom	Verified	1.21572266407627	0.112045293771399	no	591	0.108566338845327	416	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION|PLASMA MEMBRANE		Monocarboxylate/proton symporter of the plasma membrane; transport activity is dependent on the pH gradient across the membrane; mediates high-affinity uptake of carbon sources lactate, pyuvate, and acetate, and also of the micronutrient selenite, whose structure mimics that of monocarboxylates; expression and localization are tightly regulated, with transcription repression, mRNA degradation, and protein endocytosis and degradation all occurring in the presence of glucose	plasma membrane lactate transport|plasma membrane selenite transport|plasma membrane pyruvate transport	selenite:hydrogen symporter activity|secondary active monocarboxylate transmembrane transporter activity	mitochondrion|integral to membrane|plasma membrane
YOR101W	YOR101W	RAS1	hom	Verified	1.21452320288027	0.112273997488767	no	592	0.0803937593434017	358	NA	FT	SIGNALING|NUCLEOTIDE METABOLISM	PLASMA MEMBRANE		GTPase involved in G-protein signaling in adenylate cyclase activation; plays a role in cell proliferation; localized to the plasma membrane; homolog of mammalian RAS proto-oncogenes; relative distribution to the nucleus increases upon DNA replication stress	adenylate cyclase-activating G-protein coupled receptor signaling pathway|replicative cell aging|Ras protein signal transduction	GTPase activity	plasma membrane
YIL137C	YIL137C	TMA108	hom	Verified	1.21376384418864	0.112418958306093	no	593	0.10642097268153	429	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|PROTEOLYSIS			Protein that associates with ribosomes and is involved in ribosome biogenesis; putative metalloprotease	ribosome biogenesis	molecular_function	ribosome|cytoplasm
YDR115W	YDR115W	YDR115W	hom	Verified	1.21082514058085	0.112981213866872	no	594	0.111281161568679	411	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Putative mitochondrial ribosomal protein of the large subunit; similar to E. coli L34 ribosomal protein; required for respiratory growth, as are most mitochondrial ribosomal proteins; protein increases in abundance and relocalizes to the plasma membrane upon DNA replication stress	mitochondrial translation	structural constituent of ribosome	mitochondrial large ribosomal subunit
YHR028C	YHR028C	DAP2	hom	Verified	1.21046699768275	0.113049873509318	no	595	0.135588362353938	456	NA	FT	PROTEOLYSIS			Dipeptidyl aminopeptidase, synthesized as a glycosylated precursor; localizes to the vacuolar membrane; similar to Ste13p	protein processing	dipeptidyl-peptidase activity	fungal-type vacuole membrane
YOR008C	YOR008C	SLG1	hom	Verified	1.20872868346674	0.113383549067553	no	596	0.187483708064002	678	NA	FF|FT	VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|SIGNALING|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION|PEROXISOME ORGANIZATION	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON		Sensor-transducer of the stress-activated PKC1-MPK1 kinase pathway; involved in maintenance of cell wall integrity; required for mitophagy; involved in organization of the actin cytoskeleton; secretory pathway Wsc1p is required for the arrest of secretion response	positive regulation of endocytosis|Rho protein signal transduction|actin cytoskeleton organization|fungal-type cell wall organization|response to heat|peroxisome degradation|establishment of cell polarity|response to osmotic stress	transmembrane signaling receptor activity	plasma membrane|mating projection tip|cellular bud neck
YIL093C	YIL093C	RSM25	hom	Verified	1.20383368519226	0.114326933600582	no	597	0.133447716458622	518	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the small subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YDR258C	YDR258C	HSP78	hom	Verified	1.20067173909245	0.114939280426989	no	598	0.0926847840325992	341	NA	FT	PROTEIN LOCALIZATION|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Oligomeric mitochondrial matrix chaperone that cooperates with Ssc1p in mitochondrial thermotolerance after heat shock; able to prevent the aggregation of misfolded proteins as well as resolubilize protein aggregates	positive regulation of mitochondrial translation in response to stress|protein refolding|protein stabilization|protein import into mitochondrial matrix|mitochondrial genome maintenance|protein unfolding|cellular response to heat	misfolded protein binding|ATPase activity	mitochondrion|mitochondrial matrix
YMR295C	YMR295C	YMR295C	hom	Verified	1.19990530984145	0.115088058774724	no	599	0.107497281957173	388	NA	FT		SITE OF POLARIZED GROWTH		Protein of unknown function that associates with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and bud; YMR295C is not an essential gene; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	ribosome|cellular bud|mating projection tip
YMR118C_p	YMR118C	SHH3	hom	Uncharacterized	1.19871625430949	0.115319147774557	no	600	0.0934980992632759	350	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Putative mitochondrial inner membrane protein of unknown function; although similar to Sdh3p, Shh3p is not a stoichiometric subunit of either succinate dehydrogenase or of the TIM22 translocase	biological_process	molecular_function	integral to membrane
YLR421C	YLR421C	RPN13	hom	Verified	1.19852839375247	0.115355687999216	no	601	0.124096435863158	465	NA	FT	PROTEOLYSIS	NUCLEUS		Subunit of the 19S regulatory particle of the 26S proteasome lid; acts as a ubiquitin receptor for the proteasome; null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; protein abundance increases in response to DNA replication stress	ubiquitin-dependent protein catabolic process	ubiquitin binding	proteasome storage granule|proteasome regulatory particle, lid subcomplex
YDR089W	YDR089W	YDR089W	hom	Verified	1.19842145222916	0.115376492567058	no	602	0.0845481373725797	328	NA	FT	MEMBRANE ORGANIZATION			Protein of unknown function; deletion confers resistance to nickel; contains an SPX domain, which is found in proteins involved in phosphate homeostasis; relocalizes from vacuole to cytoplasm upon DNA replication stress	cellular membrane organization	molecular_function	integral to membrane|membrane
YLL007C_p	YLL007C	YLL007C	hom	Uncharacterized	1.19820836880328	0.115417954093149	no	603	0.152750840782093	548	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL007C is not an essential gene	biological_process	molecular_function	cytoplasm
YCR021C	YCR021C	HSP30	hom	Verified	1.19814790356377	0.115429721277735	no	604	0.0918899093121469	315	NA	FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS	PLASMA MEMBRANE		Hydrophobic plasma membrane localized, stress-responsive protein that negatively regulates the H(+)-ATPase Pma1p; induced by heat shock, ethanol treatment, weak organic acid, glucose limitation, and entry into stationary phase	negative regulation of ATPase activity|response to stress	molecular_function	integral to membrane|plasma membrane
YOL090W	YOL090W	MSH2	hom	Verified	1.19794632281142	0.11546895721454	no	605	0.125306195785443	471	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|GENE SILENCING	NUCLEUS|CHROMOSOME		Protein that forms heterodimers with Msh3p and Msh6p that bind to DNA mismatches to initiate the mismatch repair process; contains a Walker ATP-binding motif required for repair activity and involved in interstrand cross-link repair; Msh2p-Msh6p binds to and hydrolyzes ATP	mismatch repair|mitotic recombination|meiotic gene conversion|meiotic mismatch repair|removal of nonhomologous ends|DNA recombination|chromatin silencing at silent mating-type cassette	loop DNA binding|single base insertion or deletion binding|ATP binding|Y-form DNA binding|double-strand/single-strand DNA junction binding|DNA insertion or deletion binding|guanine/thymine mispair binding|four-way junction DNA binding|ATPase activity	MutSbeta complex|nuclear chromosome|MutSalpha complex|nucleus
YDR363W	YDR363W	ESC2	hom	Verified	1.19653504900588	0.115743914801487	no	606	0.134484920656917	487	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION|GENE SILENCING	NUCLEUS		Sumo-like domain protein; prevents accumulation of toxic intermediates during replication-associated recombinational repair; roles in silencing, lifespan, chromatid cohesion and the intra-S-phase DNA damage checkpoint; RENi family member	intra-S DNA damage checkpoint|double-strand break repair via homologous recombination|chromatin silencing at silent mating-type cassette|mitotic sister chromatid cohesion	molecular_function	nucleus
YDR247W	YDR247W	VHS1	hom	Verified	1.19591983821437	0.115863921358693	no	607	0.0883666848986822	381	NA	FT	CELL CYCLE|PROTEIN PHOSPHORYLATION			Cytoplasmic serine/threonine protein kinase; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; homolog of Sks1p	protein phosphorylation|G1/S transition of mitotic cell cycle	protein serine/threonine kinase activity|protein kinase activity	cytoplasm
YPR008W	YPR008W	HAA1	hom	Verified	1.19361513760641	0.116314274910615	no	608	0.105840972272117	389	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Transcriptional activator involved in adaptation to weak acid stress; activates transcription of TPO2, YRO2, and other genes encoding membrane stress proteins; HAA1 has a paralog, CUP2, that arose from the whole genome duplication; relocalizes from cytoplasm to nucleus upon DNA replication stress	response to acid|positive regulation of transcription from RNA polymerase II promoter in response to stress|positive regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding RNA polymerase II transcription factor activity	nucleus
YDR244W	YDR244W	PEX5	hom	Verified	1.19261473152327	0.11651014686281	no	609	0.139254367220054	445	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|PEROXISOME ORGANIZATION			Peroxisomal membrane signal receptor for the C-terminal tripeptide signal sequence (PTS1) of peroxisomal matrix proteins, required for peroxisomal matrix protein import; also proposed to have PTS1-receptor independent functions	protein import into peroxisome matrix, docking	peroxisome matrix targeting signal-1 binding|protein binding, bridging	cytosol|peroxisomal membrane|peroxisome
YPL156C	YPL156C	PRM4	hom	Verified	1.19251699025492	0.116529296402328	no	610	0.0902220838153691	373	NA					Pheromone-regulated protein proposed to be involved in mating; predicted to have 1 transmembrane segment; transcriptionally regulated by Ste12p during mating and by Cat8p during the diauxic shift	biological_process	molecular_function	integral to membrane
YPL162C_p	YPL162C	YPL162C	hom	Uncharacterized	1.19230379361837	0.116571073785153	no	611	0.115909049524461	415	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the membrane of vacuole with cell cycle-correlated morphology	biological_process	molecular_function	fungal-type vacuole membrane|integral to membrane
YLR059C	YLR059C	REX2	hom	Verified	1.19150193099635	0.116728299517822	no	612	0.127028847496658	434	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		3'-5' RNA exonuclease; involved in 3'-end processing of U4 and U5 snRNAs, 5S and 5.8S rRNAs, and RNase P and RNase MRP RNA; localized to mitochondria and null suppresses escape of mtDNA to nucleus in yme1 yme2 mutants; RNase D exonuclease	U5 snRNA 3'-end processing|U4 snRNA 3'-end processing|mitochondrial genome maintenance|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	3'-5'-exoribonuclease activity|3'-5' exonuclease activity	mitochondrion
YNR059W	YNR059W	MNT4	hom	Verified	1.19124668806494	0.116778377971991	no	613	0.114521958346148	455	NA	FT	CARBOHYDRATE METABOLISM			Putative alpha-1,3-mannosyltransferase, not required for protein O-glycosylation	protein O-linked glycosylation	alpha-1,3-mannosyltransferase activity	cellular_component
YOR269W	YOR269W	PAC1	hom	Verified	1.19060857937248	0.116903641005276	no	614	0.0765796657040077	320	NA	FT	CELL CYCLE|CELL DIVISION	NUCLEUS|CYTOSKELETON		Involved in nuclear migration, part of the dynein/dynactin pathway; targets dynein to microtubule tips, which is necessary for sliding of microtubules along bud cortex; serves at interface between dynein's ATPase site and its microtubule binding stalk, causing individual dynein motors to remain attached to microtubules for long periods; synthetic lethal with bni1; homolog of human LIS1, mutations in which cause the severe brain disorder lissencephaly	nuclear migration along microtubule	microtubule plus-end binding	cytoplasmic microtubule|nucleus|cytoplasm
YOR293W	YOR293W	RPS10A	hom	Verified	1.18988831522037	0.117045145830256	no	615	0.0978801710495321	367	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10A has a paralog, RPS10B, that arose from the whole genome duplication	cytoplasmic translation|rRNA export from nucleus	structural constituent of ribosome	cytosolic small ribosomal subunit
YKR018C	YKR018C	YKR018C	hom	Verified	1.18822582089061	0.117372226723667	no	616	0.111529486615123	437	NA	FT		NUCLEUS|MITOCHONDRION		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress; YKR018C has a paralog, IML2, that arose from the whole genome duplication	biological_process	molecular_function	nucleus|cytoplasm
YKR028W	YKR028W	SAP190	hom	Verified	1.18637757721611	0.117736611346107	no	617	0.117355127010357	438	NA	FT	CELL CYCLE|RNA PROCESSING|SIGNALING			Protein that forms a complex with the Sit4p protein phosphatase; required for Sit4p function; member of a family of similar proteins including Sap4p, Sap155p, and Sap185p; SAP190 has a paralog, SAP185, that arose from the whole genome duplication	TOR signaling cascade|dephosphorylation|G1/S transition of mitotic cell cycle|tRNA wobble uridine modification	molecular_function	cytoplasm
YOR079C	YOR079C	ATX2	hom	Verified	1.18351057460391	0.118303429054841	no	618	0.0797449088803379	324	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Golgi membrane protein involved in manganese homeostasis; overproduction suppresses the sod1 (copper, zinc superoxide dismutase) null mutation	cellular manganese ion homeostasis	manganese ion transmembrane transporter activity	integral to membrane|Golgi membrane
YCR025C_d	YCR025C	YCR025C	hom	Dubious	1.18298175154278	0.118408189851911	no	619	0.128551419953575	521	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR025C is not an essential gene	Unknown	Unknown	Unknown
YPL212C	YPL212C	PUS1	hom	Verified	1.1826485575625	0.118474229841899	no	620	0.110464652616994	410	NA	FT	RNA PROCESSING	NUCLEUS		tRNA:pseudouridine synthase, introduces pseudouridines at positions 26-28, 34-36, 65, and 67 of tRNA; nuclear protein that appears to be involved in tRNA export; also acts on U2 snRNA	snRNA pseudouridine synthesis|tRNA pseudouridine synthesis	pseudouridine synthase activity	nucleus
YBR272C	YBR272C	HSM3	hom	Verified	1.18163705447359	0.118674872074991	no	621	0.10569726098361	374	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RESPONSE TO DNA DAMAGE	NUCLEUS		Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); involved in DNA mismatch repair during slow growth; weak similarity to Msh1p; related to human 19S subunit S5b; structural study suggests Hsm3p is a scaffold protein for Rpt1p-Rpt2p complex formation	mismatch repair|proteasome regulatory particle assembly	molecular_function	cytosol|proteasome regulatory particle, base subcomplex|nucleus|cytoplasm
YDR476C_p	YDR476C	YDR476C	hom	Uncharacterized	1.18148651510252	0.118704753647709	no	622	0.104981335416911	391	NA	FT		ENDOPLASMIC RETICULUM		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDR476C is not an essential gene	biological_process	molecular_function	endoplasmic reticulum
YBR119W	YBR119W	MUD1	hom	Verified	1.18093627919858	0.118814018895477	no	623	0.141563934608655	494	NA	FT	RNA PROCESSING	NUCLEUS		U1 snRNP A protein, homolog of human U1-A; involved in nuclear mRNA splicing	mRNA splicing, via spliceosome	U1 snRNA binding|RNA binding	U1 snRNP|U2-type prespliceosome
YHR162W	YHR162W	MPC2	hom	Verified	1.17787697398404	0.119422827986388	no	624	0.117446066837484	444	NA					Highly conserved subunit of the mitochondrial pyruvate carrier; a mitochondrial inner membrane complex comprised of Fmp37p/Mpc1p and either Mpc2p or Fmp43p/Mpc3p mediates mitochondrial pyruvate uptake; more highly expressed in glucose-containing minimal medium than in lactate-containing medium	mitochondrial pyruvate transport	pyruvate transmembrane transporter activity	mitochondrion|integral to mitochondrial inner membrane
YMR144W_p	YMR144W	YMR144W	hom	Uncharacterized	1.17532237456791	0.119932883148369	no	625	0.11492032324277	421	NA	FT		NUCLEUS		Putative protein of unknown function; localized to the nucleus; YMR144W is not an essential gene	biological_process	molecular_function	nucleus
YLR246W	YLR246W	ERF2	hom	Verified	1.17506937687935	0.119983480495528	no	626	0.0949739953788967	353	NA	FT	PROTEIN LOCALIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Subunit of a palmitoyltransferase, composed of Erf2p and Shr5p, that adds a palmitoyl lipid moiety to heterolipidated substrates such as Ras1p and Ras2p through a thioester linkage; mutants partially mislocalize Ras2p to the vacuole	protein targeting to membrane|protein palmitoylation	palmitoyltransferase activity	endoplasmic reticulum palmitoyltransferase complex|integral to endoplasmic reticulum membrane|integral to membrane
YOR115C	YOR115C	TRS33	hom	Verified	1.17473993174819	0.120049389219434	no	627	0.111436062511619	482	NA	FT	VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS	ENDOPLASMIC RETICULUM|GOLGI APPARATUS		One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic	ER to Golgi vesicle-mediated transport|protein complex assembly	molecular_function	trans-Golgi network|TRAPP complex|cis-Golgi network
YGR266W	YGR266W	YGR266W	hom	Verified	1.17306013107305	0.120385846533714	no	628	0.115053064591459	435	NA	FT		MITOCHONDRION|PLASMA MEMBRANE		Protein of unknown function; predicted to contain a single transmembrane domain; mutant has increased aneuploidy tolerance; localized to both the mitochondrial outer membrane and the plasma membrane; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	mitochondrial outer membrane|mitochondrion|plasma membrane
YLR019W	YLR019W	PSR2	hom	Verified	1.17247098388607	0.120504007520714	no	629	0.11859596048304	410	NA	FT		PLASMA MEMBRANE		Functionally redundant Psr1p homolog, a plasma membrane phosphatase involved in the general stress response; required with Psr1p and Whi2p for full activation of STRE-mediated gene expression, possibly through dephosphorylation of Msn2p	response to stress	phosphoprotein phosphatase activity	plasma membrane
YOL162W_p	YOL162W	YOL162W	hom	Uncharacterized	1.17183253740931	0.120632148293063	no	630	0.0991045337072684	360	NA					Putative protein of unknown function; member of the Dal5p subfamily of the major facilitator family	transmembrane transport	transmembrane transporter activity	integral to membrane|membrane
YNR018W	YNR018W	RCF2	hom	Verified	1.171368377595	0.120725368692372	no	631	0.110199139181106	417	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Cytochrome c oxidase subunit; has a role in assembly of respiratory supercomplexes; similar to Rcf1p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; associates with the cytochrome c oxidase - cytochrome bc1 supercomplex; null mutant accumulates reactive oxygen species; member of the conserved hypoxia induced gene family; C. elegans homolog is functional in yeast	mitochondrial respiratory chain complex IV assembly	molecular_function	mitochondrion|mitochondrial respiratory chain supercomplex|mitochondrial respiratory chain complex IV|integral to mitochondrial inner membrane
YMR151W_d	YMR151W	YIM2	hom	Dubious	1.16506039823612	0.121997272755877	no	632	0.115950578917952	408	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1	Unknown	Unknown	Unknown
YIR024C	YIR024C	YIR024C	hom	Verified	1.1648373657478	0.122042415337765	no	633	0.134920353420756	460	NA	FT		MITOCHONDRION		Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; interacts with Arh1p, a mitochondrial oxidoreductase; deletion mutant has a respiratory growth defect	biological_process	molecular_function	mitochondrion
YIL135C	YIL135C	VHS2	hom	Verified	1.16292844024125	0.122429268662534	no	634	0.0905536397279503	362	NA	FT	CELL CYCLE			Cytoplasmic protein of unknown function; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; similar to Mlf3p	G1/S transition of mitotic cell cycle	molecular_function	cytoplasm
YOL049W	YOL049W	GSH2	hom	Verified	1.16050105901559	0.12292243141347	no	635	0.121497329188489	464	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Glutathione synthetase, catalyzes the ATP-dependent synthesis of glutathione (GSH) from gamma-glutamylcysteine and glycine; induced by oxidative stress and heat shock	glutathione biosynthetic process	glutathione synthase activity	intracellular
YGR008C	YGR008C	STF2	hom	Verified	1.15871359109965	0.123286474512227	no	636	0.121426216750882	398	NA	FT		MITOCHONDRION		Protein involved in resistance to dessication stress; Stf2p exhibits antioxidant properties, and its overexpression prevents ROS accumulation and apoptosis; binds to the F0 sector of mitochondrial F1F0 ATPase in vitro and is proposed to modulate the inhibitory action of Inh1p and Stf1p; protein abundance increases in response to DNA replication stress	cellular response to desiccation	molecular_function	cytoplasm
YPL006W	YPL006W	NCR1	hom	Verified	1.15869384985842	0.123290499308209	no	637	0.119590199808397	459	NA	FT	LIPID METABOLISM			Vacuolar membrane protein that transits through the biosynthetic vacuolar protein sorting pathway, involved in sphingolipid metabolism; glycoprotein and functional orthologue of human Niemann Pick C1 (NPC1) protein	sphingolipid metabolic process	sphingolipid transporter activity	fungal-type vacuole membrane|integral to membrane
YPR022C_p	YPR022C	YPR022C	hom	Uncharacterized	1.15653047622278	0.123732120606525	no	638	0.132987124377739	446	NA	FT		NUCLEUS		Putative transcription factor, as suggested by computational analysis; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS	biological_process	sequence-specific DNA binding	nucleus|cytoplasm
YOR332W	YOR332W	VMA4	hom	Verified	1.15380383413628	0.12429030095669	no	639	0.138674328298318	483	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Subunit E of the V1 domain of the vacuolar H+-ATPase (V-ATPase); V-ATPase is an electrogenic proton pump found throughout the endomembrane system; V1 domain has eight subunits; required for the V1 domain to assemble onto the vacuolar membrane; protein abundance increases in response to DNA replication stress	vacuolar acidification	proton-transporting ATPase activity, rotational mechanism	vacuolar proton-transporting V-type ATPase, V1 domain|fungal-type vacuole membrane|integral to membrane
YJL136C	YJL136C	RPS21B	hom	Verified	1.15318330457198	0.124417577345837	no	640	0.130899046720193	437	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21B has a paralog, RPS21A, that arose from the whole genome duplication	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|cytoplasmic translation|endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome	cytosolic small ribosomal subunit
YBR026C	YBR026C	ETR1	hom	Verified	1.15269210146408	0.124518392279952	no	641	0.148517754982227	537	NA	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		2-enoyl thioester reductase, member of the medium chain dehydrogenase/reductase family; localized to in mitochondria, where it has a probable role in fatty acid synthesis	fatty acid biosynthetic process|aerobic respiration	enoyl-[acyl-carrier-protein] reductase activity	mitochondrion
YDL210W	YDL210W	UGA4	hom	Verified	1.14898330810582	0.125281431783324	no	642	0.0949248043956052	345	NA					Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane	gamma-aminobutyric acid transport|putrescine transport|transmembrane transport	putrescine transmembrane transporter activity|gamma-aminobutyric acid:hydrogen symporter activity	fungal-type vacuole membrane|integral to membrane
YIL128W	YIL128W	MET18	hom	Verified	1.1468436412651	0.125723124429126	no	643	0.219724965899406	697	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM|RESPONSE TO DNA DAMAGE	NUCLEUS		Component of cytosolic iron-sulfur protein assembly (CIA) machinery; acts at a late step of Fe-S cluster assembly; forms the CIA targeting complex with Cia1p and Cia2p that directs Fe-S cluster incorporation into a subset of proteins involved in methionine biosynthesis, DNA replication and repair, transcription, and telomere maintenance; ortholog of human MMS19	methionine metabolic process|nucleotide-excision repair|transcription from RNA polymerase II promoter	molecular_function	cytoplasm
YPR004C	YPR004C	AIM45	hom	Verified	1.14661850230093	0.125769663082473	no	644	0.123163921672213	496	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Putative ortholog of mammalian electron transfer flavoprotein complex subunit ETF-alpha; interacts with frataxin, Yfh1p; null mutant displays elevated frequency of mitochondrial genome loss; may have a role in oxidative stress response	biological_process	molecular_function	mitochondrion
YKL188C	YKL188C	PXA2	hom	Verified	1.14413663697682	0.126283487887747	no	645	0.113346282488155	416	NA	FT	NUCLEOTIDE METABOLISM			Subunit of a heterodimeric peroxisomal ATP-binding cassette transporter complex (Pxa1p-Pxa2p), required for import of long-chain fatty acids into peroxisomes; similarity to human adrenoleukodystrophy transporter ABCD1 and ABCD2 and ALD-related proteins; mutations in ABCD1 cause X-linked adrenoleukodystrophy (X-ALD), a peroxisomal disorder	fatty acid transport	ATPase activity, coupled to transmembrane movement of substances	integral to membrane|integral to peroxisomal membrane
YLR168C	YLR168C	UPS2	hom	Verified	1.14287105684061	0.126546065542289	no	646	0.125716233835516	489	NA	FT	LIPID METABOLISM|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial protein involved in phospholipid metabolism; localizes to the intermembrane space; has a role in regulation of phospholipid metabolism by inhibiting conversion of phosphatidylethanolamine to phosphatidylcholine; null mutant has defects in mitochondrial morphology; similar to Ups1p, Ups3p and to human PRELI	cristae formation|Unknown|phosphatidylethanolamine metabolic process|cardiolipin metabolic process	molecular_function	extrinsic to mitochondrial inner membrane|mitochondrion|mitochondrial intermembrane space
YEL029C	YEL029C	BUD16	hom	Verified	1.14248469695697	0.126626301709797	no	647	0.174616287397137	605	NA	FT	CELL CYCLE|CELL DIVISION|COFACTOR METABOLISM	NUCLEUS		Putative pyridoxal kinase, a key enzyme involved in pyridoxal 5'-phosphate synthesis, the active form of vitamin B6; required for genome integrity; involved in bud-site selection; similarity to yeast BUD17 and human pyridoxal kinase (PDXK)	pyridoxal phosphate biosynthetic process|cellular bud site selection	pyridoxal kinase activity	cytoplasm
YLR449W	YLR449W	FPR4	hom	Verified	1.14188282091242	0.126751365148709	no	648	0.1302514552607	486	NA	FT	CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS|CHROMOSOME		Peptidyl-prolyl cis-trans isomerase (PPIase) (proline isomerase) localized to the nucleus; catalyzes isomerization of proline residues in histones H3 and H4, which affects lysine methylation of those histones	histone peptidyl-prolyl isomerization|negative regulation of histone H3-K36 methylation|regulation of transcription by chromatin organization|chromatin silencing at rDNA|nucleosome assembly	peptidyl-prolyl cis-trans isomerase activity|macrolide binding	chromatin|nucleus
YPR077C_d	YPR077C	YPR077C	hom	Dubious	1.14184619125621	0.126758979177071	no	649	0.128028559913654	489	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; expression increased by deletion of NAP1	Unknown	Unknown	Unknown
YNR069C	YNR069C	BSC5	hom	Verified	1.14001825202967	0.127139348562389	no	650	0.13771358828846	501	NA					Protein of unknown function; shows homology with N-terminal end of Bul1p; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; readthrough expression includes YNR068C and the locus for this readthrough is termed BUL3; Bul3p is involved in ubiquitin-mediated sorting of plasma membrane proteins; readthrough and shortened forms of Bul3p interact with Rsp5p differently in vitro	biological_process	molecular_function	cellular_component
YMR138W	YMR138W	CIN4	hom	Verified	1.13892429212602	0.127367366300097	no	651	0.138745589123424	503	NA	FT	SIGNALING			GTP-binding protein involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl; regulated by the GTPase-activating protein, Cin2p, the human retinitis pigmentosa 2 (RP2) homolog	protein folding|tubulin complex assembly|tubulin complex biogenesis	GTP binding	cytoplasm
YOR118W	YOR118W	RTC5	hom	Verified	1.13811622176671	0.127535977659843	no	652	0.153018861433815	537	NA					Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; null mutation suppresses cdc13-1 temperature sensitivity	biological_process	molecular_function	cytoplasm
YER032W	YER032W	FIR1	hom	Verified	1.13314943781675	0.128575751616925	no	653	0.148487006546264	507	NA	FT	RNA PROCESSING	SITE OF POLARIZED GROWTH		Protein involved in 3' mRNA processing, interacts with Ref2p; potential Cdc28p substrate	mRNA polyadenylation|RNA polyadenylation	molecular_function	cellular bud neck
YLR448W	YLR448W	RPL6B	hom	Verified	1.13084693634239	0.129059760369142	no	654	0.14047546746447	526	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L6B; binds 5.8S rRNA; homologous to mammalian ribosomal protein L6, no bacterial homolog; RPL6B has a paralog, RPL6A, that arose from the whole genome duplication	cytoplasmic translation|ribosomal large subunit assembly	structural constituent of ribosome|RNA binding	cytosolic large ribosomal subunit
YIR030C	YIR030C	DCG1	hom	Verified	1.13071836837736	0.129086823828065	no	655	0.120519718574474	487	NA					Protein of unknown function, expression is sensitive to nitrogen catabolite repression and regulated by Dal80p; contains transmembrane domain	nitrogen compound metabolic process	molecular_function	cellular_component
YBL103C	YBL103C	RTG3	hom	Verified	1.12995990567505	0.129246559726351	no	656	0.120904295256638	425	NA	FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|SIGNALING	NUCLEUS		Basic helix-loop-helix-leucine zipper (bHLH/Zip) transcription factor that forms a complex with another bHLH/Zip protein, Rtg1p, to activate the retrograde (RTG) and TOR pathways	mitochondrion degradation|cellular response to oleic acid|mitochondria-nucleus signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription factor import into nucleus	RNA polymerase II transcription factor binding|sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity	nucleus|cytoplasm
YDR194W-A_p	YDR194W-A	YDR194W-A	hom	Uncharacterized	1.12968901806351	0.129303643153253	no	657	0.153062032211744	526	NA					Putative protein of unknown function; identified by fungal homology and RT-PCR	biological_process	molecular_function	cellular_component
YIL100W_d	YIL100W	YIL100W	hom	Dubious	1.12871419442315	0.129509209721975	no	658	0.139034706148037	403	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the dubious ORF YIL100C-A	Unknown	Unknown	Unknown
YJL038C	YJL038C	LOH1	hom	Verified	1.12590430762046	0.13010301292709	no	659	0.133078633531091	500	NA					Protein of unknown function with proposed roles in maintenance of genome integrity and also in spore wall assembly; induced during sporulation; repressed during vegetative growth by Sum1p and Hst1p; sequence similar to IRC1	chromosome organization	molecular_function	cellular_component
YER120W	YER120W	SCS2	hom	Verified	1.12536133725146	0.130217973772303	no	660	0.125964911412638	511	NA	FT	PROTEIN LOCALIZATION|LIPID METABOLISM|GENE SILENCING	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|SITE OF POLARIZED GROWTH		Integral ER membrane protein, regulates phospholipid metabolism; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PI4P levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; interacts with FFAT motif of Opi1p; involved in telomeric silencing; null shows inositol auxotrophy above 34 deg C; VAP homolog; SCS2 has a paralog, SCS22, that arose from the whole genome duplication	endoplasmic reticulum inheritance|regulation of intracellular lipid transport|negative regulation of transcription factor import into nucleus|phospholipid biosynthetic process|chromatin silencing at telomere	phosphatidylinositol binding|FFAT motif binding	nuclear membrane|integral to endoplasmic reticulum membrane|nuclear envelope|endoplasmic reticulum|cellular bud tip
YPR148C	YPR148C	YPR148C	hom	Verified	1.12493699903002	0.130307866044053	no	661	0.123168041259214	421	NA					Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern	biological_process	molecular_function	ribosome|cytoplasm
YKL168C	YKL168C	KKQ8	hom	Verified	1.12323721316579	0.130668380893587	no	662	0.113573452775594	391	NA	FT	PROTEIN PHOSPHORYLATION			Putative serine/threonine protein kinase with unknown cellular role; KKQ8 has a paralog, HAL5, that arose from the whole genome duplication	biological_process	protein kinase activity	cytoplasm
YCL063W	YCL063W	VAC17	hom	Verified	1.12280967338681	0.130759168063581	no	663	0.136552622776655	517	NA					Phosphoprotein involved in vacuole inheritance; degraded in late M phase of the cell cycle; acts as a vacuole-specific receptor for myosin Myo2p	vacuole inheritance	protein anchor	fungal-type vacuole membrane
YFR020W_p	YFR020W	YFR020W	hom	Uncharacterized	1.12137033431553	0.131065129114638	no	664	0.136265124041485	467	NA					Protein of unknown function; mRNA identified as translated by ribosome profiling data	biological_process	molecular_function	cellular_component
YIL159W	YIL159W	BNR1	hom	Verified	1.1195588359868	0.131450902705875	no	665	0.1267276011762	451	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH		Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNI1	barbed-end actin filament capping|actin filament bundle assembly|formin-nucleated actin cable assembly	profilin binding	cellular bud neck
YBR090C_p	YBR090C	YBR090C	hom	Uncharacterized	1.11908365514528	0.131552226056504	no	666	0.1101292709727	401	NA	FT		NUCLEUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus	biological_process	molecular_function	nucleus|cytoplasm
YDL119C_p	YDL119C	YDL119C	hom	Uncharacterized	1.1187694717406	0.131619249338223	no	667	0.142813309664538	575	NA	FF|FT	ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Putative mitochondrial transport protein; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in purified mitochondria	transport	transporter activity	mitochondrion|integral to membrane|mitochondrial inner membrane
YMR064W	YMR064W	AEP1	hom	Verified	1.11827139601515	0.131725549798304	no	668	0.16477293720471	564	NA	FT	TRANSLATION	MITOCHONDRION		Protein required for expression of the mitochondrial OLI1 gene encoding subunit 9 of F1-F0 ATP synthase	regulation of translation	translation regulator activity	mitochondrion
YDL187C_d	YDL187C	YDL187C	hom	Dubious	1.11805613926678	0.13177150871379	no	669	0.153150377856298	490	NA					Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YLR021W	YLR021W	IRC25	hom	Verified	1.11756423306036	0.131876575869524	no	670	0.140080096536639	515	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS			Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions	proteasome assembly|chaperone-mediated protein complex assembly|nuclear-transcribed mRNA catabolic process, non-stop decay	molecular_function	intracellular
YKR064W	YKR064W	OAF3	hom	Verified	1.11477498111851	0.132473430132667	no	671	0.146000313355399	504	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS|MITOCHONDRION		Putative transcriptional repressor with Zn(2)-Cys(6) finger; negatively regulates transcription in response to oleate levels, based on mutant phenotype and localization to oleate-responsive promoters; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; forms nuclear foci upon DNA replication stress	negative regulation of transcription from RNA polymerase II promoter|cellular response to oleic acid	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity	mitochondrion|nucleus|cytoplasm
YPR139C	YPR139C	LOA1	hom	Verified	1.11228726467202	0.133007328889347	no	672	0.171999104625434	594	NA	FT	PROTEIN LOCALIZATION|VACUOLAR TRANSPORT	ENDOPLASMIC RETICULUM		Lysophosphatidic acid acyltransferase; involved in triacelglyceride homeostasis and lipid droplet formation; localized to lipid droplets and the ER; specificity for oleoyl-CoA	lipid particle organization|cellular triglyceride homeostasis|protein targeting to vacuole	lysophosphatidic acid acyltransferase activity	endoplasmic reticulum|lipid particle|cytoplasm
YKL103C	YKL103C	APE1	hom	Verified	1.11130689681883	0.133218135876817	no	673	0.103302495049014	401	NA					Vacuolar aminopeptidase yscI; zinc metalloproteinase that belongs to the peptidase family M18; often used as a marker protein in studies of autophagy and cytosol to vacuole targeting (CVT) pathway; protein increases in abundance and relative distribution to cytoplasmic foci increases upon DNA replication stress	vacuolar protein catabolic process	metalloaminopeptidase activity	fungal-type vacuole
YEL067C_p	YEL067C	YEL067C	hom	Uncharacterized	1.10961776825353	0.133581885663343	no	674	0.138268819790028	469	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YER069W	YER069W	ARG5,6	hom	Verified	1.1068595150806	0.134177335975035	no	675	0.116807166989634	371	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS	MITOCHONDRION		Acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase; N-acetyl-L-glutamate kinase (NAGK) catalyzes the 2nd and N-acetyl-gamma-glutamyl-phosphate reductase (NAGSA), the 3rd step in arginine biosynthesis; synthesized as a precursor which is processed in the mitochondrion to yield mature NAGK and NAGSA; enzymes form a metabolon complex with Arg2p; NAGK C-terminal domain stabilizes the enzymes, slows catalysis and is involved in feed-back inhibition by arginine	ornithine biosynthetic process|arginine biosynthetic process|regulation of transcription, DNA-dependent	N-acetyl-gamma-glutamyl-phosphate reductase activity|acetylglutamate kinase activity	mitochondrion|mitochondrial matrix
YNL159C	YNL159C	ASI2	hom	Verified	1.10548368739707	0.134475029482677	no	676	0.104574578587041	410	NA	FT	PROTEOLYSIS	ENDOMEMBRANE SYSTEM|NUCLEUS		Integral inner nuclear membrane protein that acts with Asi1p and Asi3p to ensure the fidelity of SPS-sensor signalling by maintaining the dormant repressed state of gene expression in the absence of inducing signals	ubiquitin-dependent protein catabolic process	molecular_function	nuclear inner membrane
YER059W	YER059W	PCL6	hom	Verified	1.10243071043808	0.135137233206772	no	677	0.117264928522496	441	NA	FT	CELL CYCLE|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS		Pho85p cyclin of the Pho80p subfamily; forms the major Glc8p kinase together with Pcl7p and Pho85p; involved in the control of glycogen storage by Pho85p; stabilized by Elongin C binding	regulation of glycogen catabolic process|regulation of glycogen biosynthetic process	cyclin-dependent protein kinase regulator activity	cyclin-dependent protein kinase holoenzyme complex
YNL025C	YNL025C	SSN8	hom	Verified	1.10111524781622	0.135423250798907	no	678	0.153687808369933	564	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Cyclin-like component of the RNA polymerase II holoenzyme, involved in phosphorylation of the RNA polymerase II C-terminal domain; involved in glucose repression and telomere maintenance	positive regulation of transcription from RNA polymerase II promoter during meiosis|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription by galactose|positive regulation of transcription from RNA polymerase II promoter	cyclin-dependent protein kinase regulator activity	mediator complex
YPL115C	YPL115C	BEM3	hom	Verified	1.1008639499788	0.13547793699155	no	679	0.164821175990309	593	NA	FT	SIGNALING	SITE OF POLARIZED GROWTH		Rho GTPase activating protein (RhoGAP) involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assembly	negative regulation of Rho protein signal transduction|establishment of cell polarity	Rho GTPase activator activity|phosphatidylinositol-3-phosphate binding	cell cortex|incipient cellular bud site|mating projection tip|cytoplasm|cellular bud tip
YBL080C	YBL080C	PET112	hom	Verified	1.10038493506421	0.13558221975833	no	680	0.169043090381641	598	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; mutation is functionally complemented by the bacterial GatB ortholog	glutaminyl-tRNAGln biosynthesis via transamidation|mitochondrial translation	glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity	mitochondrion|glutamyl-tRNA(Gln) amidotransferase complex
YOL138C	YOL138C	RTC1	hom	Verified	1.09868484194672	0.13595277825202	no	681	0.13859438218023	502	NA					Subunit of the SEA (Seh1-associated) complex, a coatomer-related complex that associates dynamically with the vacuole; null mutation suppresses cdc13-1 temperature sensitivity; has N-terminal WD-40 repeats and a C-terminal RING motif	biological_process	molecular_function	ribosome|fungal-type vacuole|Seh1-associated complex|extrinsic to fungal-type vacuolar membrane
YLR032W	YLR032W	RAD5	hom	Verified	1.09847125477686	0.135999381472235	no	682	0.147688618601542	574	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		DNA helicase; proposed to promote replication fork regression during postreplication repair by template switching; RING finger containing ubiquitin ligase; stimulates the synthesis of free and PCNA-bound polyubiquitin chains by Ubc13p-Mms2p; required for error-prone translesion synthesis; forms nuclear foci upon DNA replication stress	double-strand break repair|postreplication repair|protein polyubiquitination|free ubiquitin chain polymerization	four-way junction helicase activity|four-way junction DNA binding|DNA-dependent ATPase activity|Y-form DNA binding	nuclear chromatin
YJR120W	YJR120W	YJR120W	hom	Verified	1.09833929012312	0.136028180698117	no	683	0.133730803364697	478	NA	FT	OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY			Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p	cellular respiration|sterol transport|mitochondrion organization	molecular_function	cellular_component
YFL018C	YFL018C	LPD1	hom	Verified	1.09734531849341	0.13624523363605	no	684	0.137535959913402	521	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS	MITOCHONDRION		Dihydrolipoamide dehydrogenase, the lipoamide dehydrogenase component (E3) of the pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase multi-enzyme complexes	L-serine biosynthetic process|2-oxoglutarate metabolic process|leucine catabolic process|glycine catabolic process|isoleucine catabolic process|pyruvate metabolic process|valine catabolic process|hydrogen peroxide metabolic process	glycine dehydrogenase (decarboxylating) activity|pyruvate dehydrogenase activity|oxoglutarate dehydrogenase (succinyl-transferring) activity|dihydrolipoyl dehydrogenase activity	mitochondrial nucleoid|mitochondrion|glycine cleavage complex|mitochondrial oxoglutarate dehydrogenase complex
YLR443W	YLR443W	ECM7	hom	Verified	1.0962484942312	0.136485021348145	no	685	0.136481619514745	543	NA	FT	ION HOMEOSTASIS|CELL WALL ORG/BIOGENESIS|ION HOMEOSTASIS			Non-essential putative integral membrane protein with a role in calcium uptake; mutant has cell wall defects and Ca+ uptake deficiencies; transcription is induced under conditions of zinc deficiency	fungal-type cell wall organization|calcium ion transport	molecular_function	integral to membrane
YJL213W	YJL213W	YJL213W	hom	Verified	1.09413437173528	0.136948024784661	no	686	0.122996270436445	416	NA					Protein of unknown function that may interact with ribosomes; periodically expressed during the yeast metabolic cycle; phosphorylated in vitro by the mitotic exit network (MEN) kinase complex, Dbf2p/Mob1p	biological_process	molecular_function	ribosome
YOR130C	YOR130C	ORT1	hom	Verified	1.09112646870829	0.13760861874383	no	687	0.11799417761214	467	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		Ornithine transporter of the mitochondrial inner membrane, exports ornithine from mitochondria as part of arginine biosynthesis; human ortholog is associated with hyperammonaemia-hyperornithinaemia-homocitrullinuria (HHH) syndrome	arginine biosynthetic process|mitochondrial ornithine transport	L-ornithine transmembrane transporter activity	mitochondrial envelope|integral to membrane
YER042W	YER042W	MXR1	hom	Verified	1.09037145419043	0.137774775523897	no	688	0.156104352190311	552	NA	FT	OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		Methionine-S-sulfoxide reductase, involved in the response to oxidative stress; protects iron-sulfur clusters from oxidative inactivation along with MXR2; involved in the regulation of lifespan	cellular response to oxidative stress	peptide-methionine-(S)-S-oxide reductase activity	nucleus|cytoplasm
YHR138C	YHR138C	YHR138C	hom	Verified	1.08868931013468	0.138145458707192	no	689	0.135826435775181	432	NA	FT	MEMBRANE ORGANIZATION			Protein of unknown function; similar to Pbi2p; double null mutant lacking Pbi2p and Yhr138cp exhibits highly fragmented vacuoles; protein abundance increases in response to DNA replication stress	vacuole fusion, non-autophagic	endopeptidase inhibitor activity	cellular_component
YOR071C	YOR071C	NRT1	hom	Verified	1.08814460468238	0.138265637542372	no	690	0.125820876916855	463	NA	FT		PLASMA MEMBRANE		High-affinity nicotinamide riboside transporter; also transports thiamine with low affinity; shares sequence similarity with Thi7p and Thi72p; proposed to be involved in 5-fluorocytosine sensitivity	thiamine transport|nicotinamide riboside transport	nicotinamide riboside transporter activity	integral to membrane|plasma membrane
YFR009W	YFR009W	GCN20	hom	Verified	1.08732987175649	0.138445525766943	no	691	0.188242152293446	689	NA	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|NUCLEOTIDE METABOLISM		RIBOSOME	Positive regulator of the Gcn2p kinase activity, forms a complex with Gcn1p; proposed to stimulate Gcn2p activation by an uncharged tRNA	regulation of translational elongation	ATPase activity	cytosol|cytosolic ribosome
YDL073W_p	YDL073W	YDL073W	hom	Uncharacterized	1.08611161898778	0.138714806228153	no	692	0.170053901564334	637	NA					Putative protein of unknown function; YDL073W is not an essential gene	biological_process	molecular_function	cellular_component
YMR115W	YMR115W	MGR3	hom	Verified	1.08556518882136	0.138835704016651	no	693	0.131189607144479	466	NA	FT	PROTEOLYSIS	MITOCHONDRION		Subunit of the mitochondrial (mt) i-AAA protease supercomplex, which degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr1p that binds to substrates to facilitate proteolysis; required for growth of cells lacking mtDNA	misfolded or incompletely synthesized protein catabolic process	misfolded protein binding	mitochondrion|mitochondrial inner membrane|i-AAA complex
YOR013W_d	YOR013W	IRC11	hom	Dubious	1.08280257231988	0.139448031777787	no	694	0.113037481976397	454	NA					Dubious opening reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YOR012C; null mutant displays increased levels of spontaneous Rad52 foci	Unknown	Unknown	Unknown
YDL238C	YDL238C	GUD1	hom	Verified	1.08167133425423	0.139699297494036	no	695	0.140796583947303	514	NA					Guanine deaminase, a catabolic enzyme of the guanine salvage pathway producing xanthine and ammonia from guanine; activity is low in exponentially-growing cultures but expression is increased in post-diauxic and stationary-phase cultures	guanine metabolic process	guanine deaminase activity|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	cytoplasm
YBR019C	YBR019C	GAL10	hom	Verified	1.08128286443103	0.139785653693902	no	696	0.130127312224036	487	NA	FT	CARBOHYDRATE METABOLISM			UDP-glucose-4-epimerase, catalyzes the interconversion of UDP-galactose and UDP-D-glucose in galactose metabolism; also catalyzes the conversion of alpha-D-glucose or alpha-D-galactose to their beta-anomers	galactose catabolic process via UDP-galactose	aldose 1-epimerase activity|UDP-glucose 4-epimerase activity	cytosol
YOL035C_d	YOL035C	YOL035C	hom	Dubious	1.08062179248558	0.139932692300019	no	697	0.131890327027472	462	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YOR338W_p	YOR338W	YOR338W	hom	Uncharacterized	1.07864896003864	0.140372123340458	no	698	0.118563415437894	467	NA	FT	TRANSCRIPTION FROM RNA POL II			Putative protein of unknown function; YOR338W transcription is regulated by Azf1p and its transcript is a specific target of the G protein effector Scp160p; identified as being required for sporulation in a high-throughput mutant screen; YOR338W has a paralog, FUN19, that arose from the whole genome duplication	ascospore formation|positive regulation of transcription from RNA polymerase II promoter	molecular_function	cellular_component
YGL045W	YGL045W	RIM8	hom	Verified	1.07815871214356	0.140481466941041	no	699	0.179535849196354	639	NA	FF|FT	VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Protein involved in proteolytic activation of Rim101p in response to alkaline pH; interacts with ESCRT-1 subunits Stp22p and Vps28p; essential for anaerobic growth; member of the arrestin-related trafficking adaptor family	meiosis|protein processing|invasive growth in response to glucose limitation|ubiquitin-dependent endocytosis	molecular_function	internal side of plasma membrane
YDR199W_d	YDR199W	YDR199W	hom	Dubious	1.07571645489537	0.141027042996789	no	700	0.16478877325663	580	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VPS64; computationally predicted to have thiol-disulfide oxidoreductase activity	Unknown	Unknown	Unknown
YNL009W	YNL009W	IDP3	hom	Verified	1.07506431091221	0.141172968261099	no	701	0.136295134870259	463	NA	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Peroxisomal NADP-dependent isocitrate dehydrogenase; catalyzes oxidation of isocitrate to alpha-ketoglutarate with the formation of NADP(H+), required for growth on unsaturated fatty acids; IDP3 has a paralog, IDP2, that arose from the whole genome duplication	NADPH regeneration|fatty acid beta-oxidation|isocitrate metabolic process	isocitrate dehydrogenase (NADP+) activity	mitochondrion|peroxisome|cytoplasm
YAL051W	YAL051W	OAF1	hom	Verified	1.07415389415864	0.14137685641456	no	702	0.12878850075044	447	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|GENE SILENCING	NUCLEUS		Oleate-activated transcription factor; acts alone and as a heterodimer with Pip2p; activates genes involved in beta-oxidation of fatty acids and peroxisome organization and biogenesis; OAF1 has a paralog, PIP2, that arose from the whole genome duplication	cellular response to oleic acid|positive regulation of fatty acid beta-oxidation|positive regulation of chromatin silencing at telomere|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YIL069C	YIL069C	RPS24B	hom	Verified	1.07266328629195	0.141711109270433	no	703	0.11892201023296	462	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION	NUCLEUS	RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S24, no bacterial homolog; RPS24B has a paralog, RPS24A, that arose from the whole genome duplication	cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome	cytosolic small ribosomal subunit
YDR393W	YDR393W	SHE9	hom	Verified	1.07214528604458	0.141827390507203	no	704	0.160735884609928	587	NA	FT	MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial inner membrane protein required for normal mitochondrial morphology, may be involved in fission of the inner membrane; forms a homo-oligomeric complex	mitochondrion organization|inner mitochondrial membrane organization	molecular_function	mitochondrial inner membrane
YGR249W	YGR249W	MGA1	hom	Verified	1.07095121561055	0.142095682773147	no	705	0.146606990178577	543	NA	FT		NUCLEUS		Protein similar to heat shock transcription factor; multicopy suppressor of pseudohyphal growth defects of ammonium permease mutants	filamentous growth	sequence-specific DNA binding|DNA binding|sequence-specific DNA binding transcription factor activity	nucleus
YOL058W	YOL058W	ARG1	hom	Verified	1.07077015696044	0.142136394296231	no	706	0.163935515959832	566	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Arginosuccinate synthetase, catalyzes the formation of L-argininosuccinate from citrulline and L-aspartate in the arginine biosynthesis pathway; potential Cdc28p substrate	argininosuccinate metabolic process|arginine biosynthetic process|citrulline metabolic process	argininosuccinate synthase activity	cytosol
YOR233W	YOR233W	KIN4	hom	Verified	1.0706578435516	0.142161652234375	no	707	0.122584486969004	474	NA	FT	CELL CYCLE|PROTEIN PHOSPHORYLATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Serine/threonine protein kinase; inhibits the mitotic exit network (MEN) when the spindle position checkpoint is activated; localized asymmetrically to mother cell cortex, spindle pole body and bud neck; KIN4 has a paralog, FRK1, that arose from the whole genome duplication	mitotic cell cycle spindle orientation checkpoint|protein phosphorylation	protein serine/threonine kinase activity|protein kinase activity	cell cortex|spindle pole body|cellular bud neck
YFL032W_d	YFL032W	YFL032W	hom	Dubious	1.07042903092533	0.142213118846251	no	708	0.156840313161748	582	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene HAC1/YFL031W; YFL032W is not an essential gene	Unknown	Unknown	Unknown
YDR485C	YDR485C	VPS72	hom	Verified	1.06893357164722	0.142549801593844	no	709	0.199828984612497	721	NA	FF|FT	CHROMATIN ORGANIZATION	NUCLEUS|CHROMOSOME		Htz1p-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting	chromatin remodeling|histone exchange	histone binding	Swr1 complex|nucleus|cytoplasm
YJL216C	YJL216C	IMA5	hom	Verified	1.06880704182099	0.142578312812915	no	710	0.163040616328303	583	NA	FT	CARBOHYDRATE METABOLISM			Alpha-glucosidase; specificity for isomaltose, maltose, and palatinose, but not alpha-methylglucoside; member of the IMA isomaltase family; not required for isomaltose utilization, but Ima5p overexpression allows the ima1 null mutant to grow on isomaltose	disaccharide catabolic process	oligo-1,6-glucosidase activity	cellular_component
YEL060C	YEL060C	PRB1	hom	Verified	1.06848952182922	0.142649877207992	no	711	0.108536804074387	389	NA	FT	PROTEOLYSIS|RESPONSE TO NUTRIENT LEVELS			Vacuolar proteinase B (yscB); serine protease of the subtilisin family; involved in protein degradation in the vacuole and required for full protein degradation during sporulation; activity inhibited by Pbi2p; protein abundance increases in response to DNA replication stress	vacuolar protein catabolic process|sporulation resulting in formation of a cellular spore|cellular response to starvation	serine-type endopeptidase activity	fungal-type vacuole lumen|fungal-type vacuole
YNL202W	YNL202W	SPS19	hom	Verified	1.06751768013156	0.142869067125049	no	712	0.163608581700034	602	NA	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS			Peroxisomal 2,4-dienoyl-CoA reductase, auxiliary enzyme of fatty acid beta-oxidation; homodimeric enzyme required for growth and sporulation on petroselineate medium; expression induced during late sporulation and in the presence of oleate	fatty acid catabolic process|ascospore formation	2,4-dienoyl-CoA reductase (NADPH) activity	peroxisomal matrix
YGR259C_d	YGR259C	YGR259C	hom	Dubious	1.06697862788321	0.142990743476082	no	713	0.130960851040048	478	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF TNA1/YGR260W	Unknown	Unknown	Unknown
YCL005W-A	YCL005W-A	VMA9	hom	Verified	1.06692260685775	0.14300339271099	no	714	0.17465791852095	631	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|CELL WALL ORG/BIOGENESIS|ION HOMEOSTASIS			Vacuolar H+ ATPase subunit e of the V-ATPase V0 subcomplex; essential for vacuolar acidification; interacts with the V-ATPase assembly factor Vma21p in the ER; involved in V0 biogenesis	cell wall mannoprotein biosynthetic process|vacuolar acidification|protein complex assembly|transmembrane transport	ATPase activity, coupled to transmembrane movement of ions	vacuolar proton-transporting V-type ATPase, V0 domain|fungal-type vacuole membrane
YDR128W	YDR128W	MTC5	hom	Verified	1.06393056233233	0.143680078358917	no	715	0.118739790796124	421	NA					Subunit of the SEA (Seh1-associated) complex; SEA is a coatomer-related complex that associates dynamically with the vacuole; has N-terminal WD-40 repeats and a C-terminal RING motif; mtc5 is synthetically sick with cdc13-1; relative distribution to vacuolar membrane punctae decreases upon DNA replication stress	biological_process	molecular_function	fungal-type vacuole membrane|Seh1-associated complex|extrinsic to fungal-type vacuolar membrane
YHR045W_p	YHR045W	YHR045W	hom	Uncharacterized	1.06374614353197	0.143721857395916	no	716	0.138854647417913	503	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	ENDOPLASMIC RETICULUM		Putative protein of unknown function; possible role in iron metabolism and/or amino acid and carbohydrate metabolism; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum	biological_process	molecular_function	endoplasmic reticulum
YHR181W	YHR181W	SVP26	hom	Verified	1.05961609337251	0.144659644532117	no	717	0.1459459316243	509	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Integral membrane protein of the early Golgi apparatus and endoplasmic reticulum, involved in COP II vesicle transport; may also function to promote retention of proteins in the early Golgi compartment	protein retention in Golgi apparatus|fungal-type cell wall organization|protein glycosylation|ER to Golgi vesicle-mediated transport	COPII adaptor activity	integral to endoplasmic reticulum membrane|integral to membrane|endoplasmic reticulum|integral to Golgi membrane|ER to Golgi transport vesicle
YNR052C	YNR052C	POP2	hom	Verified	1.05870861989921	0.144866250482411	no	718	0.223211893422357	775	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|RNA PROCESSING	NUCLEUS|SITE OF POLARIZED GROWTH		RNase of the DEDD superfamily, subunit of the Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation	regulation of transcription from RNA polymerase II promoter|positive regulation of transcription elongation from RNA polymerase II promoter|nuclear-transcribed mRNA poly(A) tail shortening|transcription elongation from RNA polymerase II promoter	3'-5'-exoribonuclease activity	CCR4-NOT core complex|mating projection tip|cytoplasmic mRNA processing body|cytoplasm
YDR069C	YDR069C	DOA4	hom	Verified	1.05768364478621	0.145099847049709	no	719	0.16768212710272	639	NA	FT	VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|PROTEOLYSIS	MITOCHONDRION		Ubiquitin isopeptidase, required for recycling ubiquitin from proteasome-bound ubiquitinated intermediates, acts at the late endosome/prevacuolar compartment to recover ubiquitin from ubiquitinated membrane proteins en route to the vacuole	protein deubiquitination|endocytosis|regulation of DNA replication|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|free ubiquitin chain depolymerization|ubiquitin homeostasis|ubiquitin-dependent protein catabolic process	endopeptidase activity|ubiquitin-specific protease activity|ubiquitin thiolesterase activity	endosome|proteasome complex|mitochondrion
YIL028W_d	YIL028W	YIL028W	hom	Dubious	1.05634103085941	0.145406218304929	no	720	0.157972613159076	483	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YEL031W	YEL031W	SPF1	hom	Verified	1.05624714521223	0.145427658348941	no	721	0.211072703128555	757	NA	FF|FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION|GOLGI APPARATUS		P-type ATPase, ion transporter of the ER membrane; required to maintain normal lipid composition of intracellular compartments and proper targeting of mitochondrial outer membrane tail-anchored proteins; involved in ER function and Ca2+ homeostasis; required for regulating Hmg2p degradation; confers sensitivity to a killer toxin (SMKT) produced by Pichia farinosa KK1	cellular calcium ion homeostasis|transmembrane transport	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism	mitochondrion|integral to membrane|endoplasmic reticulum membrane|cis-Golgi network
YKR030W	YKR030W	GMH1	hom	Verified	1.05594173970406	0.145497416491988	no	722	0.124292286994775	489	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Golgi membrane protein of unknown function, interacts with Gea1p and Gea2p; required for localization of Gea2p; computational analysis suggests a possible role in either cell wall synthesis or protein-vacuolar targeting	transport	molecular_function	integral to membrane|integral to Golgi membrane
YGR219W_d	YGR219W	YGR219W	hom	Dubious	1.05536284618933	0.145629704197093	no	723	0.170317294234298	533	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MRPL9/YGR220C	Unknown	Unknown	Unknown
YPL040C	YPL040C	ISM1	hom	Verified	1.05518992700429	0.145669235059269	no	724	0.167547524369195	582	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth	isoleucyl-tRNA aminoacylation|mitochondrial isoleucyl-tRNA aminoacylation|mitochondrial translation	isoleucine-tRNA ligase activity	mitochondrion
YKL136W_d	YKL136W	YKL136W	hom	Dubious	1.05493422767167	0.14572770341884	no	725	0.172261671235001	555	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF APL2/YKL135C	Unknown	Unknown	Unknown
YKR085C	YKR085C	MRPL20	hom	Verified	1.05300360864536	0.146169669090564	no	726	0.15832852885904	571	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YOL104C	YOL104C	NDJ1	hom	Verified	1.04879246350777	0.147136823437267	no	727	0.123732470913839	458	NA	FT	CELL CYCLE	NUCLEUS|CHROMOSOME		Meiosis-specific telomere protein, required for bouquet formation, effective homolog pairing, ordered cross-over distribution, sister chromatid cohesion at meiotic telomeres, chromosomal segregation and telomere-led rapid prophase movement	meiotic telomere clustering|synapsis|attachment of telomeric heterochromatin to nuclear envelope|regulation of reciprocal meiotic recombination|reciprocal meiotic recombination	telomeric DNA binding	nuclear chromosome, telomeric region
YPR021C	YPR021C	AGC1	hom	Verified	1.04641971336017	0.147683647544989	no	728	0.154810609088037	577	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Mitochondrial amino acid transporter, acts both as a glutamate uniporter and as an aspartate-glutamate exchanger; involved in nitrogen metabolism and nitrogen compound biosynthesis	L-glutamate transport|aspartate transport|cellular nitrogen compound biosynthetic process	antiporter activity|L-aspartate transmembrane transporter activity|L-glutamate transmembrane transporter activity|uniporter activity	mitochondrion|integral to membrane|mitochondrial inner membrane
YMR021C	YMR021C	MAC1	hom	Verified	1.04528983924882	0.147944516153485	no	729	0.264603924101684	942	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|ION HOMEOSTASIS|ION HOMEOSTASIS	NUCLEUS		Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport	cellular copper ion homeostasis|positive regulation of protein catabolic process|positive regulation of transcription from RNA polymerase II promoter	core promoter proximal region DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YOR189W	YOR189W	IES4	hom	Verified	1.04383893708807	0.1482799567617	no	730	0.151643665471778	536	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Component of the INO80 chromatiin remodeling complex and target of the Mec1p/Tel1p DNA damage signaling pathway; proposed to link chromatin remodeling to replication checkpoint responses	response to DNA damage stimulus	molecular_function	nucleus|Ino80 complex
YER063W	YER063W	THO1	hom	Verified	1.04370159503609	0.148311735829464	no	731	0.113012384341665	412	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA LOCALIZATION	NUCLEUS		Conserved nuclear RNA-binding protein; specifically binds to transcribed chromatin in a THO- and RNA-dependent manner, genetically interacts with shuttling hnRNP NAB2; overproduction suppresses transcriptional defect caused by hpr1 mutation	poly(A)+ mRNA export from nucleus|transcription, DNA-dependent|ribonucleoprotein complex assembly	chromatin binding|double-stranded DNA binding|RNA binding	nucleus
YPL081W	YPL081W	RPS9A	hom	Verified	1.04137435510069	0.148850919912185	no	732	0.150499427609546	554	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION	NUCLEUS	RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S9 and bacterial S4; RPS9A has a paralog, RPS9B, that arose from the whole genome duplication	cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome|rRNA binding	small-subunit processome|cytosolic small ribosomal subunit|90S preribosome|cytoplasm
YBR264C	YBR264C	YPT10	hom	Verified	1.04091983183807	0.148956378350701	no	733	0.147311881675318	508	NA	FT	PROTEIN LOCALIZATION|SIGNALING	PLASMA MEMBRANE		Rab family GTP-binding protein that contains the PEST signal sequence specific for proteolytic enzymes; may be involved in vesicular transport; overexpression leads to accumulation of Golgi-like cisternae with budding vesicles	Golgi organization	GTPase activity|guanyl nucleotide binding	cytoplasm
YHR050W-A_p	YHR050W-A	YHR050W-A	hom	Uncharacterized	1.04076123410453	0.148993187924836	no	734	0.148338718319507	523	NA					Protein of unknown function; identified by expression profiling and mass spectrometry	biological_process	molecular_function	cellular_component
YJR044C	YJR044C	VPS55	hom	Verified	1.03953658204964	0.149277626874462	no	735	0.152101381093927	523	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT			Late endosomal protein involved in late endosome to vacuole trafficking; functional homolog of human obesity receptor gene-related protein (OB-RGRP)	late endosome to vacuole transport via multivesicular body sorting pathway	molecular_function	Vps55/Vps68 complex|late endosome|integral to membrane
YJR111C_p	YJR111C	YJR111C	hom	Uncharacterized	1.03493417006394	0.150349827753083	no	736	0.144951468459849	566	NA	FT	OXIDATION-REDUCTION PROCESS	MITOCHONDRION		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondria	biological_process	molecular_function	mitochondrion
YDR524C-B_p	YDR524C-B	YDR524C-B	hom	Uncharacterized	1.03167188668799	0.151112925837361	no	737	0.183481547793374	667	NA	FT		PLASMA MEMBRANE		Putative protein of unknown function; YDR524C-B has a paralog, YCL048W-A, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YLR393W	YLR393W	ATP10	hom	Verified	1.0312098322644	0.151221215427435	no	738	0.147484596722229	496	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial inner membrane protein required for assembly of the F0 sector of mitochondrial F1F0 ATP synthase, interacts genetically with ATP6	mitochondrial proton-transporting ATP synthase complex assembly	unfolded protein binding	integral to mitochondrial membrane|mitochondrion|mitochondrial inner membrane
YMR180C	YMR180C	CTL1	hom	Verified	1.02826424126615	0.151912773453319	no	739	0.135614649030645	477	NA	FT	RNA PROCESSING	NUCLEUS		RNA 5'-triphosphatase, localizes to both the nucleus and cytoplasm	biological_process	polynucleotide 5'-phosphatase activity	nucleus|cytoplasm
YML036W	YML036W	CGI121	hom	Verified	1.0275458066617	0.152081763832179	no	740	0.1749960688117	602	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS|CHROMOSOME		Component of the EKC/KEOPS complex with Bud32p, Kae1p, Pcc1p, and Gon7p; EKC/KEOPS complex is required for t6A tRNA modification and may have roles in telomere maintenance and transcription; Cgi121p is dispensable for tRNA modification	telomere maintenance|positive regulation of transcription from RNA polymerase II promoter	molecular_function	EKC/KEOPS complex
YKL174C	YKL174C	TPO5	hom	Verified	1.02553741480379	0.1525548403973	no	741	0.132455001239278	453	NA	FT		ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Protein involved in excretion of putrescine and spermidine; putative polyamine transporter in the Golgi or post-Golgi vesicles	polyamine transport	polyamine transmembrane transporter activity	integral to membrane|Golgi apparatus
YDR375C	YDR375C	BCS1	hom	Verified	1.02430583409615	0.152845421596722	no	742	0.171605833264917	591	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases	protein insertion into mitochondrial membrane from inner side|chaperone-mediated protein complex assembly|mitochondrial respiratory chain complex III assembly	protein transmembrane transporter activity|ATPase activity	mitochondrion|mitochondrial inner membrane
YIL130W	YIL130W	ASG1	hom	Verified	1.02287792159535	0.153182784822669	no	743	0.145147253440837	556	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Zinc cluster protein proposed to function as a transcriptional regulator involved in the stress response; null mutants have a respiratory deficiency, calcofluor white sensitivity and slightly increased cycloheximide resistance	biological_process	sequence-specific DNA binding	nucleus
YNL333W	YNL333W	SNZ2	hom	Verified	1.02206593400062	0.153374847566437	no	744	0.152743419544655	531	NA	FT	COFACTOR METABOLISM			Member of a stationary phase-induced gene family; transcription of SNZ2 is induced prior to diauxic shift, and also in the absence of thiamin in a Thi2p-dependent manner; forms a coregulated gene pair with SNO2; interacts with Thi11p	pyridoxine metabolic process|thiamine biosynthetic process	protein binding	cellular_component
YCR082W	YCR082W	AHC2	hom	Verified	1.02195632973325	0.153400784926417	no	745	0.167830480916304	601	NA	FT	CHROMATIN ORGANIZATION	NUCLEUS	HISTONE ACETYLTRANSFERASE	Component of the ADA histone acetyltransferase complex; Ach2p and Ach1p are unique to the ADA complex and not shared with the related SAGA and SLIK complexes; may tether Ach1p to the complex	histone acetylation	histone acetyltransferase activity	Ada2/Gcn5/Ada3 transcription activator complex|nucleus|cytoplasm
YNR050C	YNR050C	LYS9	hom	Verified	1.02103528548018	0.153618860726659	no	746	0.16248980106217	582	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS			Saccharopine dehydrogenase (NADP+, L-glutamate-forming); catalyzes the formation of saccharopine from alpha-aminoadipate 6-semialdehyde, the seventh step in lysine biosynthesis pathway; exhibits genetic and physical interactions with TRM112	lysine biosynthetic process via aminoadipic acid	saccharopine dehydrogenase (NADP+, L-glutamate-forming) activity	cytoplasm
YDL107W	YDL107W	MSS2	hom	Verified	1.02092780157504	0.153644323077599	no	747	0.15475080752978	550	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Peripherally bound inner membrane protein of the mitochondrial matrix involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18p	protein insertion into mitochondrial membrane from inner side	molecular_function	extrinsic to mitochondrial inner membrane|mitochondrial matrix
YKL147C_d	YKL147C	YKL147C	hom	Dubious	1.01958183633068	0.153963411487218	no	748	0.10405116262732	384	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene AVT3	Unknown	Unknown	Unknown
YBL048W_d	YBL048W	RRT1	hom	Dubious	1.01823225134849	0.154283797990997	no	749	0.175971016961065	629	NA					Identified in a screen for mutants with increased levels of rDNA transcription; dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data	Unknown	Unknown	Unknown
YEL033W_p	YEL033W	MTC7	hom	Uncharacterized	1.01779552334244	0.154387569963433	no	750	0.199095420864247	684	NA					Predicted metabolic role based on network analysis derived from ChIP experiments, a large-scale deletion study and localization of transcription factor binding sites; null mutant is sensitive to temperature oscillation in a cdc13-1 mutant	biological_process	molecular_function	cellular_component
YLR133W	YLR133W	CKI1	hom	Verified	1.01402079799679	0.15528641414322	no	751	0.20111177272935	672	NA	FT	LIPID METABOLISM			Choline kinase; catalyzes the first step in phosphatidylcholine synthesis via the CDP-choline (Kennedy pathway); exhibits some ethanolamine kinase activity contributing to phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway; CKI1 has a paralog, EKI1, that arose from the whole genome duplication	phosphatidylethanolamine biosynthetic process|phosphatidylcholine biosynthetic process	ethanolamine kinase activity|choline kinase activity	cytoplasm
YGR025W_d	YGR025W	YGR025W	hom	Dubious	1.01292036738435	0.155549099513476	no	752	0.123104115287858	410	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YOL014W_p	YOL014W	YOL014W	hom	Uncharacterized	1.01289031904755	0.155556276504094	no	753	0.179885773331211	619	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YAR035W	YAR035W	YAT1	hom	Verified	1.01139213297138	0.155914392487939	no	754	0.140287276257837	499	NA	FT	KETONE METABOLISM|LIPID METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		Outer mitochondrial carnitine acetyltransferase, minor ethanol-inducible enzyme involved in transport of activated acyl groups from the cytoplasm into the mitochondrial matrix; phosphorylated	carnitine metabolic process|alcohol metabolic process	carnitine O-acetyltransferase activity	mitochondrion
YPL042C	YPL042C	SSN3	hom	Verified	1.00997307238219	0.156254095649377	no	755	0.196670855977856	688	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Cyclin-dependent protein kinase, component of RNA polymerase II holoenzyme; involved in phosphorylation of the RNA polymerase II C-terminal domain; involved in glucose repression	phosphorylation of RNA polymerase II C-terminal domain|negative regulation of transcription from RNA polymerase II promoter|negative regulation of filamentous growth|protein phosphorylation|protein destabilization|nuclear-transcribed mRNA catabolic process, non-stop decay|positive regulation of transcription from RNA polymerase II promoter by galactose	RNA polymerase II carboxy-terminal domain kinase activity|protein kinase activity|cyclin-dependent protein kinase activity	mediator complex
YPR197C_d	YPR197C	YPR197C	hom	Dubious	1.00819004872711	0.156681617139358	no	756	0.22302824473265	782	NA	FF				Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YIL053W	YIL053W	RHR2	hom	Verified	1.00674852100123	0.157027819353771	no	757	0.182936842762922	653	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS		Constitutively expressed glycerol-1-phosphatase; involved in glycerol biosynthesis, induced in response to both anaerobic and osmotic stress; RHR2 has a paralog, HOR2, that arose from the whole genome duplication	glycerol biosynthetic process|response to osmotic stress	glycerol-1-phosphatase activity	nucleus|cytoplasm
YBR009C	YBR009C	HHF1	hom	Verified	1.00638055075526	0.157116272895854	no	758	0.142212582614952	528	NA	FT	CHROMATIN ORGANIZATION	NUCLEUS|CHROMOSOME		Histone H4, core histone protein required for chromatin assembly and chromosome function; one of two identical histone proteins (see also HHF2); contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity	chromatin assembly or disassembly|sexual sporulation resulting in formation of a cellular spore|histone H3-K79 methylation	DNA binding	replication fork protection complex|nuclear nucleosome
YBR251W	YBR251W	MRPS5	hom	Verified	1.00628578549362	0.157139058094613	no	759	0.204720012686349	690	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the small subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YDR266C	YDR266C	HEL2	hom	Verified	1.00602987426141	0.157200599814237	no	760	0.163191329850968	513	NA					RING finger ubiquitin ligase (E3); involved in ubiquitylation and degradation of excess histones; interacts with Ubc4p and Rad53p; null mutant sensitive to hydroxyurea (HU); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; computational analysis suggests a role as a transcription factor	biological_process	molecular_function	ribosome|cytoplasm
YLL017W	YLL017W	YLL017W	hom	pseudogene	1.00533698724996	0.157367305321941	no	761	0.115500026146154	396	NA	FT	SIGNALING			Non-essential Ras guanine nucleotide exchange factor (GEF); localized to the membrane; expressed in poor nutrient conditions and on nonfermentable carbon sources; contains a stop codon in S288C, full-length gene includes YLL016W; SDC25 has a paralog, CDC25, that arose from the whole genome duplication	Ras protein signal transduction	Ras guanyl-nucleotide exchange factor activity	membrane
YHR182W	YHR182W	YHR182W	hom	Verified	1.00527506358871	0.157382209531902	no	762	0.17898338872308	554	NA	FT	SIGNALING			Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and cytoplasm; relocalizes from bud neck to cytoplasm upon DNA replication stress	biological_process	molecular_function	cytoplasm
YDR402C	YDR402C	DIT2	hom	Verified	1.00517688695072	0.157405841257654	no	763	0.169331278528981	570	NA	FT	CELL WALL ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS			N-formyltyrosine oxidase, sporulation-specific microsomal enzyme involved in the production of N,N-bisformyl dityrosine required for spore wall maturation, homologous to cytochrome P-450s	ascospore wall assembly	oxidoreductase activity	cellular_component
YGR160W_d	YGR160W	YGR160W	hom	Dubious	1.00508114475327	0.15742888924465	no	764	0.143449499262982	488	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDR287W	YDR287W	INM2	hom	Verified	1.00497021277842	0.157455596635383	no	765	0.157989319080804	555	NA	FT	LIPID METABOLISM|CARBOHYDRATE METABOLISM			Inositol monophosphatase, involved in biosynthesis of inositol; enzymatic activity requires magnesium ions and is inhibited by lithium and sodium ions; inm1 inm2 double mutant lacks inositol auxotrophy	inositol phosphate dephosphorylation	inositol monophosphate 1-phosphatase activity	cellular_component
YNL014W	YNL014W	HEF3	hom	Verified	1.00417309284185	0.157647594551175	no	766	0.170048706397096	572	NA	FT	TRANSLATION|NUCLEOTIDE METABOLISM		RIBOSOME	Translational elongation factor EF-3; member of the ABC superfamily; stimulates EF-1 alpha-dependent binding of aminoacyl-tRNA by the ribosome; normally expressed in zinc deficient cells; HEF3 has a paralog, YEF3, that arose from the whole genome duplication	translational elongation	ATPase activity|translation elongation factor activity	cytosolic ribosome
YBR020W	YBR020W	GAL1	hom	Verified	1.00311083139326	0.157903694611739	no	767	0.14961060948611	550	NA	FT	CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS			Galactokinase; phosphorylates alpha-D-galactose to alpha-D-galactose-1-phosphate in the first step of galactose catabolism; expression regulated by Gal4p; GAL1 has a paralog, GAL3, that arose from the whole genome duplication	galactose catabolic process via UDP-galactose|carbohydrate phosphorylation|positive regulation of transcription by galactose	galactokinase activity	cytoplasm
YDR322W	YDR322W	MRPL35	hom	Verified	1.00255740813648	0.158037227315884	no	768	0.179973049446208	603	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YKL126W	YKL126W	YPK1	hom	Verified	1.00161363017966	0.158265117689614	no	769	0.329038973054532	1171	NA	FF|FT	VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS|PROTEIN PHOSPHORYLATION	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Serine/threonine protein kinase; phosphorylates and downregulates flippase activator Fpk1p; inactivates Orm1p and Orm2p (inhibitors of serine:palmitoyl-coenzyme A transferase) by phosphorylation in response to compromised sphingolipid synthesis; mutations affect receptor-mediated endocytosis and sphingolipid-mediated and cell integrity signaling pathways; homolog of mammalian kinase SGK; YPK1 has a paralog, YPK2, that arose from the whole genome duplication	eisosome assembly|protein autophosphorylation|negative regulation of phospholipid translocation|protein phosphorylation	protein serine/threonine kinase activity	cytosol|plasma membrane|cellular bud neck
YEL072W	YEL072W	RMD6	hom	Verified	1.00128492282485	0.158344539974581	no	770	0.157767745152809	556	NA	FT	CELL CYCLE			Protein required for sporulation	biological_process	molecular_function	cellular_component
YHR044C	YHR044C	DOG1	hom	Verified	1.00096122401183	0.158422777645492	no	771	0.135790096643381	482	NA	FT	CARBOHYDRATE METABOLISM			2-deoxyglucose-6-phosphate phosphatase; paralogous to DOG2; member of a family of low molecular weight phosphatases; confers 2-deoxyglucose resistance when overexpressed, in vivo substrate has not yet been identified	glucose metabolic process	2-deoxyglucose-6-phosphatase activity	cellular_component
YHR026W	YHR026W	VMA16	hom	Verified	1.00063342884594	0.158502031237881	no	772	0.261611550875634	872	NA	FF|FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Subunit c'' of the vacuolar ATPase, which functions in acidification of the vacuole; one of three proteolipid subunits of the V0 domain	vacuolar acidification	proton-transporting ATPase activity, rotational mechanism	vacuolar proton-transporting V-type ATPase, V0 domain|integral to membrane
YMR187C_p	YMR187C	YMR187C	hom	Uncharacterized	0.999098367656149	0.158873520916883	no	773	0.155285758696005	539	NA					Putative protein of unknown function; YMR187C is not an essential gene	biological_process	molecular_function	integral to membrane
YJL063C	YJL063C	MRPL8	hom	Verified	0.998214679375229	0.159087634881409	no	774	0.181883821541833	660	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit	mitochondrial genome maintenance|mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YGR037C	YGR037C	ACB1	hom	Verified	0.997865039758561	0.159172403265442	no	775	0.244812115460509	859	NA	FF|FT	KETONE METABOLISM|LIPID METABOLISM	NUCLEUS		Acyl-CoA-binding protein, transports newly synthesized acyl-CoA esters from fatty acid synthetase (Fas1p-Fas2p) to acyl-CoA-consuming processes; subject to starvation-induced, Grh1p-mediated unconventional secretion; protein abundance increases in response to DNA replication stress	long-chain fatty acid transport|chronological cell aging|fatty acid metabolic process	long-chain fatty acid transporter activity|fatty-acyl-CoA binding	extracellular region|nucleus|cytoplasm
YNR009W	YNR009W	NRM1	hom	Verified	0.997376698091217	0.159290848780531	no	776	0.146700051936778	507	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE	NUCLEUS		Transcriptional co-repressor of MBF (MCB binding factor)-regulated gene expression; Nrm1p associates stably with promoters via MBF to repress transcription upon exit from G1 phase	negative regulation of transcription involved in G1 phase of mitotic cell cycle	repressing transcription factor binding|transcription factor binding transcription factor activity	MBF transcription complex|nucleus|cytoplasm
YKR026C	YKR026C	GCN3	hom	Verified	0.997060236504258	0.159367636213766	no	777	0.207671348149935	777	NA	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION			Alpha subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a positive regulator of GCN4 expression	regulation of translational initiation	enzyme regulator activity|guanyl-nucleotide exchange factor activity|translation initiation factor activity	eukaryotic translation initiation factor 2B complex|guanyl-nucleotide exchange factor complex
YDR332W	YDR332W	IRC3	hom	Verified	0.995879033486002	0.159654461796331	no	778	0.161953505646315	602	NA	FT		MITOCHONDRION		Putative RNA helicase of the DEAH/D-box family; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion	biological_process	ATP-dependent RNA helicase activity	mitochondrion
YJR108W	YJR108W	ABM1	hom	Verified	0.995377154318116	0.159776432783372	no	779	0.144448362067284	498	NA	FT	CYTOSKELETON ORGANIZATION			Protein of unknown function, required for normal microtubule organization	microtubule cytoskeleton organization	molecular_function	cellular_component
YOR205C	YOR205C	GEP3	hom	Verified	0.995300499428166	0.159795067478559	no	780	0.156258323892727	577	NA	FT		MITOCHONDRION		Protein required for mitochondrial ribosome small subunit biogenesis; null mutant is defective in respiration and in maturation of 15S rRNA; protein is localized to the mitochondrial inner membrane; null mutant interacts synthetically with prohibitin (phb1)	maturation of SSU-rRNA	molecular_function	mitochondrion|mitochondrial inner membrane
YDL239C	YDL239C	ADY3	hom	Verified	0.994657281206841	0.1599514889364	no	781	0.150914306118486	460	NA	FT	CELL CYCLE|CELL WALL ORG/BIOGENESIS|CELL DIVISION|MITOCHONDRION ORGANIZATION	NUCLEUS|CYTOSKELETON		Protein required for spore wall formation; thought to mediate assembly of a Don1p-containing structure at the leading edge of the prospore membrane via interaction with spindle pole body components; potentially phosphorylated by Cdc28p; ADY3 has a paralog, CNM67, that arose from the whole genome duplication	mitochondrion inheritance|ascospore wall assembly|sporulation resulting in formation of a cellular spore	molecular_function	spindle pole body|prospore membrane
YJL217W	YJL217W	REE1	hom	Verified	0.993726358200829	0.160178053363932	no	782	0.160918448382257	600	NA					Cytoplasmic protein involved in the regulation of enolase (ENO1); mRNA expression is induced by calcium shortage, copper deficiency (via Mac1p) and the presence of galactose (via Gal4p); mRNA expression is also regulated by the cell cycle	biological_process	molecular_function	cytoplasm
YHL042W_p	YHL042W	YHL042W	hom	Uncharacterized	0.992706565371975	0.16042648725368	no	783	0.14401128873707	483	NA					Putative protein of unknown function; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins	biological_process	molecular_function	cellular_component
YOR035C	YOR035C	SHE4	hom	Verified	0.992116732786435	0.160570292477164	no	784	0.26362467064213	939	NA	FF|FT	CYTOSKELETON ORGANIZATION|RNA LOCALIZATION			Protein containing a UCS (UNC-45/CRO1/SHE4) domain, binds to myosin motor domains to regulate myosin function; involved in endocytosis, polarization of the actin cytoskeleton, and asymmetric mRNA localization	mating type switching|intracellular mRNA localization|actin cytoskeleton organization	myosin binding	cytoplasm
YHR063C	YHR063C	PAN5	hom	Verified	0.99102832308822	0.160835875194252	no	785	0.175988203024741	600	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM			2-dehydropantoate 2-reductase, part of the pantothenic acid pathway, structurally homologous to E. coli panE	pantothenate biosynthetic process	2-dehydropantoate 2-reductase activity	cytoplasm
YKR021W	YKR021W	ALY1	hom	Verified	0.987714482441798	0.161646249853234	no	786	0.156625891786546	549	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION			Alpha arrestin that controls nutrient-mediated intracellular sorting of permease Gap1p; interacts with AP-1 subunit Apl4p; may regulate endocytosis of plasma membrane proteins by recruiting ubiquitin ligase Rsp5p to plasma membrane targets; ALY1 has a paralog, ALY2, that arose from the whole genome duplication	Unknown|regulation of intracellular transport|ubiquitin-dependent endocytosis	ubiquitin protein ligase binding	late endosome|cytoplasm|early endosome
YHR121W	YHR121W	LSM12	hom	Verified	0.987703940499624	0.161648832044889	no	787	0.156723485945071	551	NA	FT		NUCLEUS		Protein of unknown function that may function in RNA processing; interacts with Pbp1p and Pbp4p and associates with ribosomes; contains an RNA-binding LSM domain and an AD domain; GFP-fusion protein is induced by the DNA-damaging agent MMS; relative distribution to the nucleus increases upon DNA replication stress	RNA metabolic process	RNA binding	ribosome|nucleus|cytoplasmic stress granule|cytoplasm
YMR086W	YMR086W	SEG1	hom	Verified	0.987523951981485	0.161692923406176	no	788	0.157146657051644	569	NA					Component of eisosome required for proper eisosome assembly; precedes Pil1p/Lsp1p during eisosome formation and controls eisosome length and shape; Seg1p-GFP diffusely distributed and forms heterogeneous patches at the plasma membrane in small buds, also found in medium and large buds; may interact with ribosomes, based on co-purification experiments; expression is repressed by cAMP; similar to A. gossypii SEG gene and to S. pombe Sle1p, important for generating eisosomes	biological_process	molecular_function	eisosome|ribosome|cytoplasm
YKL148C	YKL148C	SDH1	hom	Verified	0.985629584647282	0.162157457430124	no	789	0.198221479416269	732	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Flavoprotein subunit of succinate dehydrogenase; couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain; FAD binding to Sdh1p is required for the assembly of the succinate dehydrogenase subunits	cellular respiration|mitochondrial electron transport, succinate to ubiquinone|tricarboxylic acid cycle	succinate dehydrogenase (ubiquinone) activity|flavin adenine dinucleotide binding	mitochondrial respiratory chain complex II|mitochondrion|mitochondrial membrane
YDR010C_d	YDR010C	YDR010C	hom	Dubious	0.985522446265521	0.162183755688407	no	790	0.185933010892171	614	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YER124C	YER124C	DSE1	hom	Verified	0.985227113552121	0.162256262629834	no	791	0.174334586582499	621	NA	FT	CELL CYCLE|SIGNALING|CELL WALL ORG/BIOGENESIS|CELL DIVISION	SITE OF POLARIZED GROWTH		Daughter cell-specific protein, may regulate cross-talk between the mating and filamentation pathways; deletion affects cell separation after division and sensitivity to alpha-factor and drugs affecting the cell wall; relocalizes from bud neck to cytoplasm upon DNA replication stress	cytokinesis, completion of separation|regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion|invasive growth in response to glucose limitation	molecular_function	cellular bud neck
YGR238C	YGR238C	KEL2	hom	Verified	0.985076649474827	0.162293211080596	no	792	0.154259329559098	586	NA	FT	CELL CYCLE	SITE OF POLARIZED GROWTH		Protein that functions in a complex with Kel1p to negatively regulate mitotic exit, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential Cdc28p substrate	conjugation with cellular fusion|negative regulation of exit from mitosis	molecular_function	mating projection tip|cellular bud neck|cellular bud tip
YOL037C_d	YOL037C	YOL037C	hom	Dubious	0.985015558736293	0.162308214285357	no	793	0.173964203991098	600	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOL036W	Unknown	Unknown	Unknown
YAL024C	YAL024C	LTE1	hom	Verified	0.984917502640285	0.162332297657665	no	794	0.218264795813206	765	NA	FF|FT	VESICLE-MEDIATED TRANSPORT|CELL CYCLE|SIGNALING|CELL DIVISION			Protein similar to GDP/GTP exchange factors but without detectable GEF activity; required for asymmetric localization of Bfa1p at daughter-directed spindle pole bodies and for mitotic exit at low temperatures	regulation of exit from mitosis|mitotic cell cycle spindle orientation checkpoint|vesicle-mediated transport	guanyl-nucleotide exchange factor activity	cellular bud
YEL047C	YEL047C	FRD1	hom	Verified	0.984793293305566	0.162362807816807	no	795	0.158621659687557	570	NA	FT	OXIDATION-REDUCTION PROCESS	MITOCHONDRION		Soluble fumarate reductase; required with isoenzyme Osm1p for anaerobic growth; may interact with ribosomes, based on co-purification experiments; authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; similar to Arxula adeninovorans fumarate reductase; protein abundance increases in response to DNA replication stress; FRD1 has a paralog, OSM1, that arose from the whole genome duplication	cellular response to anoxia	fumarate reductase (NADH) activity	cytosol|mitochondrion|ribosome|plasma membrane
YFR011C	YFR011C	AIM13	hom	Verified	0.984286296927714	0.162487382577312	no	796	0.143768419806561	537	NA	FT	MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial protein peripheral to the inner membrane; component of the mitochondrial inner membrane organizing system (MINOS, MitOS, or MICOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture	cristae formation	molecular_function	mitochondrion|extrinsic to mitochondrial inner membrane|mitochondrial crista junction|cytoplasm|mitochondrial intermembrane space
YJL127C	YJL127C	SPT10	hom	Verified	0.984022532552024	0.162552217066283	no	797	0.162366323971089	575	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING	NUCLEUS		Putative histone acetylase with a role in transcriptional silencing, sequence-specific activator of histone genes, binds specifically and cooperatively to pairs of UAS elements in core histone promoters, functions at or near the TATA box	DNA repair|negative regulation of transcription from RNA polymerase II promoter|chromatin silencing at rDNA|chromatin remodeling|chromatin silencing at telomere|chromatin silencing at silent mating-type cassette	histone acetyltransferase activity|sequence-specific DNA binding	nucleus
YML099C	YML099C	ARG81	hom	Verified	0.983682958841478	0.162635710617044	no	798	0.1634020822284	591	NA	FT	VESICLE-MEDIATED TRANSPORT|TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type, involved in the regulation of arginine-responsive genes; acts with Arg80p and Arg82p	arginine metabolic process|negative regulation of calcium ion-dependent exocytosis	transcription cofactor activity	nucleus
YMR027W_p	YMR027W	YMR027W	hom	Uncharacterized	0.983245315345155	0.162743358467495	no	799	0.175447422593121	608	NA	FT		NUCLEUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; YMR027W is not an essential gene	biological_process	molecular_function	nucleus|cytoplasm
YBR240C	YBR240C	THI2	hom	Verified	0.982814554269354	0.162849358683096	no	800	0.185792943940453	632	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Transcriptional activator of thiamine biosynthetic genes; interacts with regulatory factor Thi3p to control expression of thiamine biosynthetic genes with respect to thiamine availability; acts together with Pdc2p to respond to thiaminediphosphate demand, possibly as related to carbon source availability; zinc finger protein of the Zn(II)2Cys6 type	thiamine biosynthetic process|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II activating transcription factor binding|RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription	nucleus
YAL023C	YAL023C	PMT2	hom	Verified	0.982692427636246	0.16287941935504	no	801	0.19771519874822	674	NA	FT	PROTEIN LOCALIZATION|CARBOHYDRATE METABOLISM|PROTEOLYSIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein O-mannosyltransferase of the ER membrane; transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; involved in ER quality control; acts in a complex with Pmt1p, can instead interact with Pmt5p; antifungal drug target; PMT2 has a paralog, PMT3, that arose from the whole genome duplication	ER-associated misfolded protein catabolic process|protein O-linked glycosylation|Unknown|protein exit from endoplasmic reticulum|protein O-linked mannosylation	dolichyl-phosphate-mannose-protein mannosyltransferase activity	integral to membrane|dolichyl-phosphate-mannose-protein mannosyltransferase complex
YML052W	YML052W	SUR7	hom	Verified	0.982510672829552	0.162924163792135	no	802	0.132396476086412	454	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION	MITOCHONDRION|PLASMA MEMBRANE		Plasma membrane protein that localizes to furrow-like invaginations (MCC patches); component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants	endocytosis|ascospore formation	molecular_function	cell cortex|eisosome|mitochondrion|membrane raft|integral to membrane|plasma membrane|actin cortical patch
YML003W_p	YML003W	YML003W	hom	Uncharacterized	0.980979045591841	0.163301537506878	no	803	0.143325984104825	483	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YNL241C	YNL241C	ZWF1	hom	Verified	0.979648952989532	0.163629715964948	no	804	0.151737090785478	548	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS			Glucose-6-phosphate dehydrogenase (G6PD); catalyzes the first step of the pentose phosphate pathway; involved in adapting to oxidatve stress; homolog of the human G6PD which is deficient in patients with hemolytic anemia; protein abundance increases in response to DNA replication stress	NADPH regeneration|response to hydrogen peroxide|pentose-phosphate shunt, oxidative branch|carbon catabolite repression of transcription	glucose-6-phosphate dehydrogenase activity	cytoplasm
YGL126W	YGL126W	SCS3	hom	Verified	0.978879507657242	0.163819759306007	no	805	0.173015577281509	613	NA	FT	LIPID METABOLISM	ENDOPLASMIC RETICULUM		Protein required for inositol prototrophy; required for normal ER membrane biosynthesis; ortholog of the FIT family of proteins involved in triglyceride droplet biosynthesis and homologous to human FIT2; disputed role in the synthesis of inositol phospholipids from inositol	phospholipid metabolic process	molecular_function	integral to membrane|endoplasmic reticulum
YGR148C	YGR148C	RPL24B	hom	Verified	0.978839652203878	0.163829607003505	no	806	0.170985378777295	554	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L24B; not essential for translation but may be required for normal translation rate; homologous to mammalian ribosomal protein L24, no bacterial homolog; RPL24B has a paralog, RPL24A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome|RNA binding	cytosolic large ribosomal subunit
YIR027C	YIR027C	DAL1	hom	Verified	0.978669272037769	0.163871709773315	no	807	0.179014111860995	613	NA					Allantoinase, converts allantoin to allantoate in the first step of allantoin degradation; expression sensitive to nitrogen catabolite repression	allantoin assimilation pathway	allantoinase activity	cellular_component
YCR005C	YCR005C	CIT2	hom	Verified	0.977758044057833	0.164097003184698	no	808	0.154531466067874	493	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Citrate synthase; catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate, peroxisomal isozyme involved in glyoxylate cycle; expression is controlled by Rtg1p and Rtg2p transcription factors; CIT2 has a paralog, CIT1, that arose from the whole genome duplication	glyoxylate cycle|glutamate biosynthetic process|citrate metabolic process	citrate (Si)-synthase activity	mitochondrion|peroxisome
YBL067C	YBL067C	UBP13	hom	Verified	0.976190220750583	0.164485104234092	no	809	0.177139241474367	627	NA	FT	PROTEOLYSIS			Putative ubiquitin-specific protease that cleaves Ub-protein fusions; UBP13 has a paralog, UBP9, that arose from the whole genome duplication	biological_process	ubiquitin-specific protease activity	cellular_component
YOL125W	YOL125W	TRM13	hom	Verified	0.973849541178209	0.165065625336806	no	810	0.122395403035454	443	NA	FT	RNA PROCESSING	NUCLEUS		2'-O-methyltransferase responsible for modification of tRNA at position 4; C-terminal domain has similarity to Rossmann-fold (RFM) superfamily of RNA methyltransferases	tRNA methylation	tRNA methyltransferase activity	nucleus|cytoplasm
YDR455C_d	YDR455C	YDR455C	hom	Dubious	0.972136399197459	0.165491348030024	no	811	0.21105035991675	757	NA	FF				Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YDR456W	Unknown	Unknown	Unknown
YGL209W	YGL209W	MIG2	hom	Verified	0.972115603842333	0.165496520118854	no	812	0.154572907154629	539	NA	FT	TRANSCRIPTION FROM RNA POL II|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS	NUCLEUS|MITOCHONDRION		Zinc finger transcriptional repressor; cooperates with Mig1p in glucose-induced repression of many genes; under low glucose conditions Mig2p relocalizes to mitochondrion, where it interacts with Ups1p and antagonizes mitochondrial fission factor, Dnm1p, indicative of a role in mitochondrial fusion or regulating morphology; regulates filamentous growth along with Mig2p in response to glucose depletion; MIG2 has a paralog, MIG3, that arose from the whole genome duplication	negative regulation of transcription from RNA polymerase II promoter by glucose|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding	mitochondrion|nucleus
YGR055W	YGR055W	MUP1	hom	Verified	0.970895504420082	0.165800158534271	no	813	0.16883636799808	571	NA	FT		PLASMA MEMBRANE		High affinity methionine permease, integral membrane protein with 13 putative membrane-spanning regions; also involved in cysteine uptake	cysteine transport|sulfur amino acid transport|methionine transport	L-methionine secondary active transmembrane transporter activity	integral to membrane|integral to plasma membrane
YCL050C	YCL050C	APA1	hom	Verified	0.970566310832319	0.165882144510365	no	814	0.164891841897683	559	NA	FT	NUCLEOTIDE METABOLISM	NUCLEUS		AP4A phosphorylase; bifunctional diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase and ADP sulfurylase involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; catalyzes phosphorolysis of dinucleoside oligophosphates, cleaving substrates' alpha/beta-anhydride bond and introducing Pi into the beta-position of the corresponding NDP formed; protein abundance increases under DNA replication stress; APA1 has a paralog, APA2, that arose from the whole genome duplication	nucleotide biosynthetic process|nucleoside catabolic process	bis(5'-nucleosyl)-tetraphosphatase activity|sulfate adenylyltransferase (ADP) activity	nucleus|cytoplasm
YGR081C	YGR081C	SLX9	hom	Verified	0.970355176993537	0.165934741383841	no	815	0.184659335280263	656	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Protein required for pre-rRNA processing; associated with the 90S pre-ribosome and 43S small ribosomal subunit precursor; interacts with U3 snoRNA; deletion mutant has synthetic fitness defect with an sgs1 deletion mutant	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	molecular_function	preribosome, small subunit precursor|nucleolus|nucleus|90S preribosome
YCR066W	YCR066W	RAD18	hom	Verified	0.970253531794743	0.16596006669921	no	816	0.191366539074022	727	NA	FF|FT	RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		E3 ubiquitin ligase; forms heterodimer with Rad6p to monoubiquitinate PCNA-K164; heterodimer binds single-stranded DNA and has single-stranded DNA dependent ATPase activity; required for postreplication repair; SUMO-targeted ubiquitin ligase (STUbl) that contains a SUMO-interacting motif (SIM) which stimulates its ubiquitin ligase activity towards the sumoylated form of PCNA	protein monoubiquitination|error-free translesion synthesis|error-free postreplication DNA repair|error-prone translesion synthesis	ubiquitin-protein ligase activity|single-stranded DNA-dependent ATPase activity|single-stranded DNA binding	nuclear chromatin|nucleus
YJL169W_d	YJL169W	YJL169W	hom	Dubious	0.969981792614337	0.166027783887588	no	817	0.153896293364804	543	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL168C/SET2	Unknown	Unknown	Unknown
YOL100W	YOL100W	PKH2	hom	Verified	0.968267664236271	0.16645535477185	no	818	0.166743678411262	579	NA	FT	VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|RNA PROCESSING|SIGNALING|CELL WALL ORG/BIOGENESIS|PROTEIN PHOSPHORYLATION	NUCLEUS		Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; redundant with Pkh1p	regulation of nuclear-transcribed mRNA poly(A) tail shortening|protein phosphorylation|MAPK cascade involved in cell wall biogenesis|cytoplasmic mRNA processing body assembly	protein kinase activity	cell cortex|eisosome|nucleus
YKR001C	YKR001C	VPS1	hom	Verified	0.966692763012871	0.16684882299582	no	819	0.260132722139645	861	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CELL DIVISION|NUCLEOTIDE METABOLISM|CYTOSKELETON ORGANIZATION|VACUOLAR TRANSPORT|PEROXISOME ORGANIZATION	MITOCHONDRION|CYTOSKELETON		Dynamin-like GTPase required for vacuolar sorting; also involved in actin cytoskeleton organization, endocytosis, late Golgi-retention of some proteins, regulation of peroxisome biogenesis	vacuolar transport|peroxisome fission|endocytosis|actin cytoskeleton organization|protein retention in Golgi apparatus|peroxisome organization|lipid tube assembly|protein targeting to vacuole	GTPase activity	mitochondrial outer membrane|fungal-type vacuole membrane|peroxisome|actin cortical patch
YLR422W_p	YLR422W	YLR422W	hom	Uncharacterized	0.966483600975981	0.166901124459535	no	820	0.17866821377191	637	NA					Protein of unknown function with similarity to human DOCK proteins (guanine nucleotide exchange factors); interacts with Ino4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm, YLR422W is not an essential protein	biological_process	molecular_function	cytoplasm
YLR110C	YLR110C	CCW12	hom	Verified	0.966108646943117	0.166994909072929	no	821	0.235867164073037	827	NA	FF|FT	CELL WALL ORG/BIOGENESIS	SITE OF POLARIZED GROWTH		Cell wall mannoprotein; plays a role in maintenance of newly synthesized areas of cell wall; localizes to periphery of small buds, septum region of larger buds, and shmoo tip; CCW12 has a paralog, YDR134C, that arose from the whole genome duplication	conjugation with cellular fusion|agglutination involved in conjugation with cellular fusion|fungal-type cell wall organization	molecular_function	fungal-type cell wall|mating projection tip|cellular bud tip
YHR021W-A_p	YHR021W-A	ECM12	hom	Uncharacterized	0.964357601168018	0.1674333356867	no	822	0.157465573596614	545	NA	FT	CELL WALL ORG/BIOGENESIS			Putative protein of unknown function; may contribute to cell wall biosynthesis, mutants display zymolyase hypersensitivity	fungal-type cell wall organization	molecular_function	cellular_component
YBL063W	YBL063W	KIP1	hom	Verified	0.963099256175986	0.167748857512534	no	823	0.14223368991772	456	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION	CYTOSKELETON		Kinesin-related motor protein required for mitotic spindle assembly, chromosome segregation, and 2 micron plasmid partitioning; functionally redundant with Cin8p for chromosomal but not plasmid functions	mitotic anaphase B|microtubule depolymerization|spindle pole body separation|plasmid partitioning|mitotic sister chromatid segregation	microtubule motor activity|structural constituent of cytoskeleton	spindle microtubule|kinesin complex|spindle pole body
YIL127C_p	YIL127C	RRT14	hom	Uncharacterized	0.9612831868974	0.16820489964027	no	824	0.157123645396213	560	NA	FT		NUCLEUS		Putative protein of unknown function; identified in a screen for mutants with decreased levels of rDNA transcription; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis	biological_process	molecular_function	nucleolus
YBR086C	YBR086C	IST2	hom	Verified	0.959949341251947	0.168540355764095	no	825	0.182144934640806	609	NA	FT		PLASMA MEMBRANE		Cortical ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; localizes to the mother cell in small-budded cells and to the bud in medium- and large-budded cells; mRNA is transported to the bud tip by an actomyosin-driven process	response to osmotic stress	lipid binding	integral to membrane|cellular bud membrane|plasma membrane
YDR159W	YDR159W	SAC3	hom	Verified	0.959847576299286	0.168565966834856	no	826	0.239823779333569	856	NA	FF|FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|RIBOSOME BIOGENESIS|RESPONSE TO DNA DAMAGE|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	Nuclear pore-associated protein; required for biogenesis of the small ribosomal subunit; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; similar to the human germinal center-associated nuclear protein (GANP)	ribosomal small subunit biogenesis|actin filament-based process|mRNA export from nucleus|mRNA 3'-end processing|mitosis|protein export from nucleus|transcription-coupled nucleotide-excision repair|nuclear retention of pre-mRNA at the site of transcription|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery	protein binding	transcription export complex 2|nuclear pore
YLR308W	YLR308W	CDA2	hom	Verified	0.959425434448316	0.168672233511514	no	827	0.164801122921563	587	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM			Chitin deacetylase, together with Cda1p involved in the biosynthesis ascospore wall component, chitosan; required for proper rigidity of the ascospore wall	ascospore wall assembly	chitin deacetylase activity	chitosan layer of spore wall
YBR176W	YBR176W	ECM31	hom	Verified	0.958767745732194	0.168837880686482	no	828	0.176917992644491	521	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM	MITOCHONDRION		Ketopantoate hydroxymethyltransferase, required for pantothenic acid biosynthesis, converts 2-oxoisovalerate into 2-dehydropantoate	pantothenate biosynthetic process	3-methyl-2-oxobutanoate hydroxymethyltransferase activity	mitochondrion
YDR368W	YDR368W	YPR1	hom	Verified	0.958084481218993	0.169010080106467	no	829	0.1649968886877	564	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		NADPH-dependent aldo-keto reductase; reduces multiple substrates including 2-methylbutyraldehyde and D,L-glyceraldehyde, expression is induced by osmotic and oxidative stress; functionally redundant with other aldo-keto reductases; protein abundance increases in response to DNA replication stress; YPR1 has a paralog, GCY1, that arose from the whole genome duplication	cellular response to oxidative stress|D-xylose catabolic process|arabinose catabolic process	glucose 1-dehydrogenase (NADP+) activity|alditol:NADP+ 1-oxidoreductase activity|carbonyl reductase (NADPH) activity	nucleus|cytoplasm
YOR251C	YOR251C	TUM1	hom	Verified	0.95778061248369	0.169086698709041	no	830	0.134650688370602	506	NA	FT	RNA PROCESSING	MITOCHONDRION		Rhodanese domain sulfur transferase, accepts persulfite from Nfs1p and transfers it to Uba4p in the pathway for 2-thiolation of the wobble uridine base of tRNAs; also stimulates sulfur transfer by Nfs1p; may be mitochondrially localized	tRNA wobble position uridine thiolation|tRNA wobble uridine modification	thiosulfate sulfurtransferase activity	cytoplasm
YGR035C_p	YGR035C	YGR035C	hom	Uncharacterized	0.957738276145931	0.169097375322123	no	831	0.148253536362215	528	NA					Putative protein of unknown function, potential Cdc28p substrate; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance	biological_process	molecular_function	cellular_component
YKR032W_d	YKR032W	YKR032W	hom	Dubious	0.957125038846938	0.16925207346426	no	832	0.149428341316437	520	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YOR358W	YOR358W	HAP5	hom	Verified	0.956188957240159	0.169488388973838	no	833	0.157628728619629	555	NA	FT	TRANSCRIPTION FROM RNA POL II|OXIDATION-REDUCTION PROCESS|RESPONSE TO NUTRIENT LEVELS|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS		Subunit of the heme-activated, glucose-repressed Hap2/3/4/5 CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; required for assembly and DNA binding activity of the complex	carbon catabolite activation of transcription from RNA polymerase II promoter|regulation of cellular respiration	RNA polymerase II core promoter proximal region sequence-specific DNA binding|DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	CCAAT-binding factor complex
YER090W	YER090W	TRP2	hom	Verified	0.954399252342855	0.169940792285854	no	834	0.378185239379817	1274	NA	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM			Anthranilate synthase, catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p	tryptophan biosynthetic process	anthranilate synthase activity	anthranilate synthase complex|cytoplasm
YLR216C	YLR216C	CPR6	hom	Verified	0.953011710345788	0.170292068728822	no	835	0.135784547013083	444	NA					Peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity; protein abundance increases in response to DNA replication stress	protein folding|protein refolding	unfolded protein binding|peptidyl-prolyl cis-trans isomerase activity	cytoplasm
YJR055W	YJR055W	HIT1	hom	Verified	0.951458728186883	0.170685780003766	no	836	0.131481538842234	501	NA	FT		NUCLEUS		Protein of unknown function, required for growth at high temperature	biological_process	molecular_function	nucleus|cytoplasm
YGR087C	YGR087C	PDC6	hom	Verified	0.95103252506125	0.170793932625997	no	837	0.167820570805331	569	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Minor isoform of pyruvate decarboxylase, decarboxylates pyruvate to acetaldehyde, involved in amino acid catabolism; transcription is glucose- and ethanol-dependent, and is strongly induced during sulfur limitation	L-phenylalanine catabolic process|ethanol metabolic process|tryptophan catabolic process|aromatic amino acid family catabolic process to alcohol via Ehrlich pathway	pyruvate decarboxylase activity	cytoplasm
YBR163W	YBR163W	EXO5	hom	Verified	0.950452007292022	0.170941314418538	no	838	0.177485795208051	658	NA	FT	MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial 5'-3' exonuclease and sliding exonuclease, required for mitochondrial genome maintenance; distantly related to the RecB nuclease domain of bacterial RecBCD recombinases; may be regulated by the transcription factor Ace2	mitochondrial genome maintenance	single-stranded DNA specific 5'-3' exodeoxyribonuclease activity	mitochondrion
YPL080C_d	YPL080C	YPL080C	hom	Dubious	0.949576539325519	0.171163731967439	no	839	0.159375649648282	519	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDR066C	YDR066C	RTR2	hom	Verified	0.949134667029078	0.171276062347783	no	840	0.173721431991172	589	NA	FT		NUCLEUS		Protein of unknown function; exhibits genetic interactions with Rtr1p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YDR066C is not an essential gene; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress; RTR2 has a paralog, RTR1, that arose from the whole genome duplication	biological_process	molecular_function	cytoplasm
YJR098C_p	YJR098C	YJR098C	hom	Uncharacterized	0.948783763037211	0.171365300827096	no	841	0.147387082321825	507	NA	FT	LIPID METABOLISM	MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion|cytoplasm
YIL030C	YIL030C	SSM4	hom	Verified	0.948716995430036	0.171382283878425	no	842	0.179442752899953	648	NA	FT	PROTEOLYSIS	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM	UBIQUITIN LIGASE COMPLEX	Ubiquitin-protein ligase involved in ER-associated protein degradation; located in the ER/nuclear envelope; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation	ER-associated protein catabolic process	ubiquitin-protein ligase activity	nuclear envelope|integral to endoplasmic reticulum membrane|Doa10p ubiquitin ligase complex|integral to membrane|nuclear inner membrane
YDR387C_p	YDR387C	YDR387C	hom	Uncharacterized	0.947113863887209	0.171790380447246	no	843	0.14221269565526	489	NA					Putative transporter, member of the sugar porter family; YDR387C is not an essential gene	transport|transmembrane transport	substrate-specific transmembrane transporter activity	integral to membrane|membrane
YMR060C	YMR060C	SAM37	hom	Verified	0.944885711763517	0.172358613434037	no	844	0.218431406048868	738	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Component of the Sorting and Assembly Machinery (SAM or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their outer membrane insertion; contributes to SAM complex stability	mitochondrial outer membrane translocase complex assembly|protein import into mitochondrial outer membrane|phospholipid transport	molecular_function	mitochondrial outer membrane|mitochondrial sorting and assembly machinery complex|mitochondrion|integral to membrane
YAL005C	YAL005C	SSA1	hom	Verified	0.944814231397571	0.172376862493496	no	845	0.137414566009183	479	NA	FT	PROTEIN LOCALIZATION|TRANSLATION|MITOCHONDRION ORGANIZATION	NUCLEUS		ATPase involved in protein folding and NLS-directed nuclear transport; member of HSP70 family; forms chaperone complex with Ydj1p; localized to nucleus, cytoplasm, and cell wall; 98% identical with paralog Ssa2p, but subtle differences between the two proteins provide functional specificity with respect to propagation of yeast [URE3] prions and vacuolar-mediated degradations of gluconeogenesis enzymes; general targeting factor of Hsp104p to prion fibrils	cytoplasmic translation|protein folding|protein refolding|protein targeting to mitochondrion|SRP-dependent cotranslational protein targeting to membrane, translocation|protein import into nucleus, translocation|response to stress	unfolded protein binding|ATPase activity	fungal-type vacuole membrane|fungal-type cell wall|plasma membrane|nucleus|polysome|chaperonin-containing T-complex|cytoplasm
YCR016W_p	YCR016W	YCR016W	hom	Uncharacterized	0.944744728675543	0.172394607838913	no	846	0.137867101012197	527	NA	FT		NUCLEUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus and nucleus; predicted to be involved in ribosome biogenesis	biological_process	molecular_function	nucleolus|nucleus
YJL133W	YJL133W	MRS3	hom	Verified	0.941406493368359	0.173248293635657	no	847	0.158067052258849	527	NA	FT	RNA PROCESSING|ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Iron transporter, mediates Fe2+ transport across inner mito membrane; mitochondrial carrier family member; active under low-iron conditions; may transport other cations; MRS3 has a paralog, MRS4, that arose from the whole genome duplication	mitochondrial iron ion transport|RNA splicing	iron ion transmembrane transporter activity	mitochondrion|integral to membrane
YPL003W	YPL003W	ULA1	hom	Verified	0.939005148262781	0.173864050550055	no	848	0.178273192590753	603	NA					Protein that acts together with Uba3p to activate Rub1p before its conjugation to proteins (neddylation), which may play a role in protein degradation	protein neddylation	NEDD8 activating enzyme activity	cellular_component
YOR367W	YOR367W	SCP1	hom	Verified	0.938624812298123	0.173961704456602	no	849	0.193266909658742	680	NA	FT	CYTOSKELETON ORGANIZATION	CYTOSKELETON		Component of yeast cortical actin cytoskeleton, binds and cross links actin filaments; originally identified by its homology to calponin (contains a calponin-like repeat) but the Scp1p domain structure is more similar to transgelin	actin filament organization|chronological cell aging	actin filament binding|protein binding, bridging	actin cortical patch
YGR204W	YGR204W	ADE3	hom	Verified	0.937279900687736	0.174307299508326	no	850	0.171341701383907	591	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM	NUCLEUS		Cytoplasmic trifunctional enzyme C1-tetrahydrofolate synthase, involved in single carbon metabolism and required for biosynthesis of purines, thymidylate, methionine, and histidine; null mutation causes auxotrophy for adenine and histidine	purine nucleobase biosynthetic process|folic acid-containing compound metabolic process	methylenetetrahydrofolate dehydrogenase (NADP+) activity|formate-tetrahydrofolate ligase activity|methenyltetrahydrofolate cyclohydrolase activity	nucleus|cytoplasm
YAL012W	YAL012W	CYS3	hom	Verified	0.936993340411527	0.174380991773666	no	851	0.215965207404997	754	NA	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM			Cystathionine gamma-lyase, catalyzes one of the two reactions involved in the transsulfuration pathway that yields cysteine from homocysteine with the intermediary formation of cystathionine; protein abundance increases in response to DNA replication stress	sulfur amino acid metabolic process|cysteine biosynthetic process|cysteine biosynthetic process via cystathionine|transsulfuration|cysteine metabolic process	cystathionine gamma-lyase activity	cytoplasm
YML076C	YML076C	WAR1	hom	Verified	0.936643346610353	0.174471023543409	no	852	0.149184001771558	509	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS|MITOCHONDRION		Homodimeric Zn2Cys6 zinc finger transcription factor; binds to a weak acid response element to induce transcription of PDR12 and FUN34, encoding an acid transporter and a putative ammonia transporter, respectively	response to acid	sequence-specific DNA binding transcription factor activity	mitochondrion|nucleus
YHR135C	YHR135C	YCK1	hom	Verified	0.936456990371256	0.174518973527209	no	853	0.169197067894996	577	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CELL DIVISION|PROTEIN PHOSPHORYLATION	ENDOPLASMIC RETICULUM|MITOCHONDRION|PLASMA MEMBRANE		Palmitoylated plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck2p in morphogenesis, proper septin assembly, endocytic trafficking; YCK1 has a paralog, YCK2, that arose from the whole genome duplication	cell morphogenesis|endocytosis|protein phosphorylation|cytokinesis|response to glucose stimulus	protein serine/threonine kinase activity|protein kinase activity	mitochondrion|endoplasmic reticulum|plasma membrane
YDR202C	YDR202C	RAV2	hom	Verified	0.935950131379429	0.174649432103596	no	854	0.201980637860229	711	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|ION HOMEOSTASIS			Subunit of RAVE (Rav1p, Rav2p, Skp1p), a complex that associates with the V1 domain of the vacuolar membrane (H+)-ATPase (V-ATPase) and promotes assembly and reassembly of the holoenzyme	vacuolar acidification|regulation of protein complex assembly	molecular_function	RAVE complex
YCR008W	YCR008W	SAT4	hom	Verified	0.933311631877988	0.175329545573364	no	855	0.172835293111424	627	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|ION HOMEOSTASIS|PROTEIN PHOSPHORYLATION|ION HOMEOSTASIS			Ser/Thr protein kinase involved in salt tolerance; funtions in regulation of Trk1p-Trk2p potassium transporter; partially redundant with Hal5p; has similarity to Npr1p	cellular cation homeostasis|protein phosphorylation|cellular protein localization|G1/S transition of mitotic cell cycle|protein dephosphorylation	protein kinase activity	cellular_component
YLL048C	YLL048C	YBT1	hom	Verified	0.933292162331325	0.175334570379063	no	856	0.168972289463307	581	NA	FT	NUCLEOTIDE METABOLISM			Transporter of the ATP-binding cassette (ABC) family; involved in bile acid transport; negative regulator of vacuole fusion; regulates the release of lumenal Ca2+ stores; similar to mammalian bile transporters	bile acid and bile salt transport	bile acid-exporting ATPase activity	integral to membrane|fungal-type vacuole
YAL062W	YAL062W	GDH3	hom	Verified	0.932294803535582	0.17559209625422	no	857	0.15407916264747	546	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS	NUCLEUS|MITOCHONDRION		NADP(+)-dependent glutamate dehydrogenase; synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources; GDH3 has a paralog, GDH1, that arose from the whole genome duplication	glutamate biosynthetic process|ammonia assimilation cycle	glutamate dehydrogenase (NADP+) activity	mitochondrion|nucleus
YOR042W	YOR042W	CUE5	hom	Verified	0.932269578920827	0.175598612554144	no	858	0.184755199354715	626	NA					Protein containing a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern	biological_process	ubiquitin binding	cytoplasm
YPL001W	YPL001W	HAT1	hom	Verified	0.932146982523519	0.175630285186163	no	859	0.192914630803507	652	NA	FT	CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING	NUCLEUS	HISTONE ACETYLTRANSFERASE	Catalytic subunit of the Hat1p-Hat2p histone acetyltransferase complex that uses the cofactor acetyl coenzyme A, to acetylate free nuclear and cytoplasmic histone H4; involved in telomeric silencing and DNA double-strand break repair	histone acetylation|chromatin silencing at telomere	histone acetyltransferase activity|histone binding	histone acetyltransferase complex|nucleus|cytoplasm
YCL002C_p	YCL002C	YCL002C	hom	Uncharacterized	0.931941931953229	0.1756832678448	no	860	0.175945539294036	617	NA					Putative protein of unknown function; YCL002C is not an essential gene	biological_process	molecular_function	integral to membrane
YHR179W	YHR179W	OYE2	hom	Verified	0.930408866368817	0.176079714820595	no	861	0.180667860650026	653	NA	FT	OXIDATION-REDUCTION PROCESS	NUCLEUS|MITOCHONDRION		Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN); responsible for geraniol reduction into citronellol during fermentation; homologous to Oye3p with different ligand binding and catalytic properties; may be involved in sterol metabolism, oxidative stress response, and programmed cell death; protein abundance increases in response to DNA replication stress	apoptotic process	NADPH dehydrogenase activity	mitochondrion|nucleus|cytoplasm
YLL023C	YLL023C	POM33	hom	Verified	0.928742020377433	0.176511399188086	no	862	0.166076744711102	541	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM	NUCLEAR PORE	Transmembrane nucleoporin; involved in nuclear pore complex (NPC) distribution, assembly or stabilization; highly conserved across species, orthologous to human TMEM33 and paralogous to Per33p; protein abundance increases in response to DNA replication stress	nuclear pore organization|nuclear pore complex assembly	structural constituent of nuclear pore	ribosome|integral to membrane|endoplasmic reticulum|nuclear pore
YAL037C-A_p	YAL037C-A	YAL037C-A	hom	Uncharacterized	0.92724898830435	0.176898636574079	no	863	0.17951444685413	617	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YPL062W_d	YPL062W	YPL062W	hom	Dubious	0.927208805894702	0.176909065821195	no	864	0.204507282529124	707	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPL062W is not an essential gene; homozygous diploid mutant shows a decrease in glycogen accumulation	Unknown	Unknown	Unknown
YCR079W	YCR079W	PTC6	hom	Verified	0.927172439629209	0.176918504932309	no	865	0.193060757100036	701	NA	FT	RESPONSE TO NUTRIENT LEVELS	MITOCHONDRION		Mitochondrial type 2C protein phosphatase (PP2C) with similarity to mammalian PP1Ks; involved in mitophagy; null mutant is sensitive to rapamycin and has decreased phosphorylation of the Pda1 subunit of pyruvate dehydrogenase	mitochondrion degradation|positive regulation of catalytic activity|macroautophagy|protein dephosphorylation	protein serine/threonine phosphatase activity	mitochondrion|mitochondrial matrix|mitochondrial intermembrane space
YOR113W	YOR113W	AZF1	hom	Verified	0.926390760236022	0.177121472067344	no	866	0.197970404086426	655	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL WALL ORG/BIOGENESIS	NUCLEUS		Zinc-finger transcription factor; in the presence of glucose, activates transcription of genes involved in growth and carbon metabolism; in nonfermentable carbon sources, activates transcription of genes involved in maintenance of cell wall integrity	regulation of fungal-type cell wall organization|regulation of transcription from RNA polymerase II promoter|cellular response to carbohydrate stimulus	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YKL039W	YKL039W	PTM1	hom	Verified	0.926195101993975	0.177172298759042	no	867	0.166436372953761	575	NA	FT		ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Protein of unknown function; copurifies with late Golgi vesicles containing the v-SNARE Tlg2p; PTM1 has a paralog, YHL017W, that arose from the whole genome duplication	biological_process	molecular_function	integral to membrane
YLR361C	YLR361C	DCR2	hom	Verified	0.925906000012059	0.177247416454723	no	868	0.151906870064689	516	NA	FT	CELL CYCLE|SIGNALING			Phosphoesterase involved in downregulation of the unfolded protein response, at least in part via dephosphorylation of Ire1p; dosage-dependent positive regulator of the G1/S phase transition through control of the timing of START	endoplasmic reticulum unfolded protein response|traversing start control point of mitotic cell cycle|protein dephosphorylation	hydrolase activity, acting on ester bonds|phosphoprotein phosphatase activity|phosphoric ester hydrolase activity	cellular_component
YJR010C-A	YJR010C-A	SPC1	hom	Verified	0.925463302689481	0.177362481976481	no	869	0.180229748936788	642	NA	FT	PROTEIN LOCALIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Subunit of the signal peptidase complex (SPC); SPC cleaves the signal sequence from proteins targeted to the endoplasmic reticulum (ER); homolog of the SPC12 subunit of mammalian signal peptidase complex; protein abundance increases in response to DNA replication stress	signal peptide processing|protein targeting to ER	molecular_function	signal peptidase complex
YLR031W_p	YLR031W	YLR031W	hom	Uncharacterized	0.921872902693441	0.178297437444854	no	870	0.192222679243471	656	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YKL061W_p	YKL061W	BLI1	hom	Uncharacterized	0.921684987374347	0.178346456773664	no	871	0.164880282678933	545	NA					Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to the endosome	biological_process	molecular_function	endosome
YOL132W	YOL132W	GAS4	hom	Verified	0.920919876432859	0.178546130211743	no	872	0.165499858891849	566	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	PLASMA MEMBRANE		1,3-beta-glucanosyltransferase, involved with Gas2p in spore wall assembly; has similarity to Gas1p; localizes to the cell wall	ascospore wall assembly	1,3-beta-glucanosyltransferase activity	fungal-type cell wall|integral to membrane
YLL027W	YLL027W	ISA1	hom	Verified	0.920777489187449	0.17858330499807	no	873	0.202066997943409	712	NA	FT	KETONE METABOLISM|COFACTOR METABOLISM	MITOCHONDRION		Protein required for maturation of mitochondrial [4Fe-4S] proteins; functions in a complex with Isa2p and possibly Iba57p; isa1 deletion causes loss of mitochondrial DNA and respiratory deficiency; depletion reduces growth on nonfermentable carbon sources; functional ortholog of bacterial A-type ISC proteins	biotin biosynthetic process|iron-sulfur cluster assembly	iron-sulfur cluster binding|iron ion binding	mitochondrial matrix
YLR406C	YLR406C	RPL31B	hom	Verified	0.920352359850607	0.178694327735286	no	874	0.21479225043286	722	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L31B; associates with karyopherin Sxm1p; loss of both Rpl31p and Rpl39p confers lethality; homologous to mammalian ribosomal protein L31, no bacterial homolog; RPL31B has a paralog, RPL31A, that arose from the whole genome duplication	cytoplasmic translation|regulation of translational fidelity	structural constituent of ribosome	cytosolic large ribosomal subunit
YGL253W	YGL253W	HXK2	hom	Verified	0.919711377763321	0.178861802663195	no	875	0.181766704171409	623	NA	FT	CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS|MITOCHONDRION		Hexokinase isoenzyme 2; catalyzes phosphorylation of glucose in the cytosol; predominant hexokinase during growth on glucose; functions in the nucleus to repress expression of HXK1 and GLK1 and to induce expression of its own gene; phosphorylation/dephosphorylation at serine-14 by protein kinase Snf1p and protein phosphatase Glc7p-Reg1p regulates nucleocytoplasmic shuttling of Hxk2p; HXK2 has a paralog, HXK1, that arose from the whole genome duplication	replicative cell aging|fructose import|regulation of transcription by glucose|glucose import|mannose metabolic process|glycolysis|glucose metabolic process|regulation of cell size|fructose metabolic process	hexokinase activity	cytosol|mitochondrion|nucleus
YCL023C_d	YCL023C	YCL023C	hom	Dubious	0.9193394178207	0.178959033134649	no	876	0.162959504592089	535	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF KCC4	Unknown	Unknown	Unknown
YOR333C_d	YOR333C	YOR333C	hom	Dubious	0.918112723482552	0.179279927170126	no	877	0.159047231859439	534	NA					Dubious open reading frame, unlikely to encode a functional protein; overlaps 5' end of MRS2 gene required for respiratory growth	Unknown	Unknown	Unknown
YGR271C-A	YGR271C-A	EFG1	hom	Verified	0.917586554674077	0.179417679804879	no	878	0.220365204256384	775	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Essential protein required for maturation of 18S rRNA; null mutant is sensitive to hydroxyurea and is delayed in recovering from alpha-factor arrest; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus	G1 phase of mitotic cell cycle|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	molecular_function	nucleolus
YCR065W	YCR065W	HCM1	hom	Verified	0.917537031395009	0.179430648579137	no	879	0.180730761266274	661	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION|RESPONSE TO OXIDATIVE STRESS	NUCLEUS|CHROMOSOME		Forkhead transcription factor that drives S-phase specific expression of genes involved in chromosome segregation, spindle dynamics, and budding; suppressor of calmodulin mutants with specific SPB assembly defects; telomere maintenance role	positive regulation of transcription involved in S-phase of mitotic cell cycle|cellular response to oxidative stress|mitochondrion organization|spindle pole body organization|positive regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding	nuclear chromatin|nucleus|cytoplasm
YER004W	YER004W	FMP52	hom	Verified	0.915361919176273	0.180000831459362	no	880	0.195128895352603	652	NA	FT		ENDOPLASMIC RETICULUM|MITOCHONDRION		Protein of unknown function, localized to the mitochondrial outer membrane; induced by treatment with 8-methoxypsoralen and UVA irradiation	biological_process	molecular_function	mitochondrial outer membrane|mitochondrion|endoplasmic reticulum
YPL205C_d	YPL205C	YPL205C	hom	Dubious	0.914178041507858	0.180311650191784	no	881	0.164144103440494	583	NA					Hypothetical protein; deletion of locus affects telomere length	Unknown	Unknown	Unknown
YBL104C	YBL104C	SEA4	hom	Verified	0.913596682007125	0.180464405253843	no	882	0.255754373527663	891	NA					Subunit of the SEA (Seh1-associated) complex, a coatomer-related complex that associates dynamically with the vacuole; has an N-terminal beta-propeller fold and a C-terminal RING motif; promoter contains multiple GCN4 binding sites	biological_process	molecular_function	Seh1-associated complex|extrinsic to fungal-type vacuolar membrane|cytoplasm
YJR088C	YJR088C	EMC2	hom	Verified	0.913480294581272	0.180494996371251	no	883	0.15151687271582	550	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm Y57G7A.10/EMC-2, fly CG17556, human TTC35	protein folding in endoplasmic reticulum	molecular_function	ER membrane protein complex|endoplasmic reticulum
YPL072W	YPL072W	UBP16	hom	Verified	0.91231027439943	0.180802703618232	no	884	0.159693080976754	556	NA	FT	PROTEOLYSIS	MITOCHONDRION		Deubiquitinating enzyme anchored to the outer mitochondrial membrane, probably not important for general mitochondrial functioning, but may perform a more specialized function at mitochondria	protein deubiquitination	ubiquitin-specific protease activity	mitochondrial outer membrane|cytoplasm
YDR249C_p	YDR249C	YDR249C	hom	Uncharacterized	0.911189483618448	0.181097772051503	no	885	0.170277335434204	562	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YDR100W	YDR100W	TVP15	hom	Verified	0.910738807723913	0.181216505621066	no	886	0.181344288685406	571	NA	FT	VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p	vesicle-mediated transport	molecular_function	COPI-coated vesicle|integral to membrane|integral to Golgi membrane
YKL169C_d	YKL169C	YKL169C	hom	Dubious	0.910423761253674	0.181299535661958	no	887	0.225121692199846	759	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene MRPL38	Unknown	Unknown	Unknown
YPL064C	YPL064C	CWC27	hom	Verified	0.90979365483693	0.181465670752245	no	888	0.198186457041197	670	NA	FT	RNA PROCESSING	NUCLEUS		Component of a complex containing Cef1p; putatively involved in pre-mRNA splicing; has similarity to S. pombe Cwf27p; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	U2-type spliceosomal complex
YIL071C	YIL071C	PCI8	hom	Verified	0.909343340574134	0.181584459862727	no	889	0.193852210487127	676	NA	FT		NUCLEUS		Possible shared subunit of Cop9 signalosome (CSN) and eIF3, binds eIF3b subunit Prt1p, has possible dual functions in transcriptional and translational control, contains a PCI (Proteasome-COP9 signalosome (CSN)-eIF3) domain	cullin deneddylation	molecular_function	signalosome
YGL060W	YGL060W	YBP2	hom	Verified	0.908646675673709	0.181768330053168	no	890	0.18675964152777	711	NA	FT	CELL CYCLE	NUCLEUS|CHROMOSOME	KINETOCHORE	Central kinetochore associated protein; mediates mitotic progression; interacts with several central kinetochore proteins and centromeric histone Cse4p; role in resistance to oxidative stress; similar to Slk19p; YBP2 has a paralog, YBP1, that arose from the whole genome duplication	G2/M transition of mitotic cell cycle	molecular_function	condensed nuclear chromosome kinetochore|centromere-specific nucleosome|cytoplasm
YJL056C	YJL056C	ZAP1	hom	Verified	0.907703798717346	0.182017368209409	no	891	0.276876837305823	937	NA	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Zinc-regulated transcription factor; binds to zinc-responsive promoters to induce transcription of certain genes in presence of zinc, represses other genes in low zinc; regulates its own transcription; contains seven zinc-finger domains	regulation of transcription from RNA polymerase II promoter in response to zinc ion starvation|positive regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding RNA polymerase II transcription factor activity|RNA polymerase II regulatory region sequence-specific DNA binding|zinc ion binding	nucleus
YOR216C	YOR216C	RUD3	hom	Verified	0.907676733156982	0.182024520071404	no	892	0.181640532476229	663	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	GOLGI APPARATUS		Golgi matrix protein involved in the structural organization of the cis-Golgi; interacts genetically with COG3 and USO1	ER to Golgi vesicle-mediated transport	molecular_function	Golgi apparatus
YIL111W	YIL111W	COX5B	hom	Verified	0.90630880715665	0.182386212611362	no	893	0.169504061990858	570	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Subunit Vb of cytochrome c oxidase; cytochrome c oxidase is the terminal member of the mitochondrial inner membrane electron transport chain; Cox5Bp is predominantly expressed during anaerobic growth while its isoform Va (Cox5Ap) is expressed during aerobic growth; COX5B has a paralog, COX5A, that arose from the whole genome duplication	mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity|nitrite reductase (NO-forming) activity	mitochondrion|integral to membrane|mitochondrial respiratory chain complex IV
YJL139C	YJL139C	YUR1	hom	Verified	0.902939528655837	0.183278994980857	no	894	0.187791101616205	670	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Mannosyltransferase involved in protein N-glycosylation; member of the KTR1 family; located in the Golgi apparatus; YUR1 has a paralog, KTR2, that arose from the whole genome duplication	cell wall mannoprotein biosynthetic process|protein N-linked glycosylation	mannosyltransferase activity	Golgi apparatus
YDR326C	YDR326C	YSP2	hom	Verified	0.899256537279956	0.184258015990745	no	895	0.191021555705317	684	NA	FT		MITOCHONDRION		Protein involved in programmed cell death; mutant shows resistance to cell death induced by amiodarone or intracellular acidification; YSP2 has a paralog, YHR080C, that arose from the whole genome duplication	apoptotic process	molecular_function	mitochondrion
YPR065W	YPR065W	ROX1	hom	Verified	0.897542644423609	0.184714714345211	no	896	0.189893179088098	666	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS|CHROMOSOME		Heme-dependent repressor of hypoxic genes; mediates aerobic transcriptional repression of hypoxia induced genes such as COX5b and CYC7; repressor function regulated through decreased promoter occupancy in response to oxidative stress; contains an HMG domain that is responsible for DNA bending activity; involved in the hyperosmotic stress resistance	negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter in response to stress	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|DNA binding, bending|sequence-specific DNA binding|RNA polymerase II transcription factor recruiting transcription factor activity	nuclear chromatin
YPR116W	YPR116W	RRG8	hom	Verified	0.896893636872741	0.184887837915504	no	897	0.183580732354003	627	NA	FT	MITOCHONDRION ORGANIZATION	MITOCHONDRION		Putative protein of unknown function, required for mitochondrial genome maintenance; null mutation results in a decrease in plasma membrane electron transport	mitochondrial genome maintenance	molecular_function	mitochondrion
YMR004W	YMR004W	MVP1	hom	Verified	0.89667594341556	0.184945930492898	no	898	0.202197776678354	675	NA	FT	PROTEIN LOCALIZATION|VACUOLAR TRANSPORT	NUCLEUS		Protein required for sorting proteins to the vacuole; Mvp1p and Vps1p act in concert to promote membrane traffic to the vacuole; participates in transcription initiation and/or early elongation of specific genes; interacts with foot domain of RNA polymerase II; deletion results in abnormal CTD-Ser5 phosphorylation of RNA polymerase II at specific promoter regions; protein abundance increases in response to DNA replication stress	protein targeting to vacuole	phosphatidylinositol-3-phosphate binding	nucleus|cytoplasm
YGL013C	YGL013C	PDR1	hom	Verified	0.896562934753208	0.184976091885961	no	899	0.307871300937069	1086	NA	FF|FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS	RSC COMPLEX	Transcription factor that regulates the pleiotropic drug response; zinc cluster protein that is a master regulator involved in recruiting other zinc cluster proteins to pleiotropic drug response elements (PDREs) to fine tune the regulation of multidrug resistance genes; PDR1 has a paralog, PDR3, that arose from the whole genome duplication	Unknown|positive regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YKL074C	YKL074C	MUD2	hom	Verified	0.896537818519787	0.184982795686195	no	900	0.156677101400459	540	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING	NUCLEUS		Protein involved in early pre-mRNA splicing; component of the pre-mRNA-U1 snRNP complex, the commitment complex; interacts with Msl5p/BBP splicing factor and Sub2p; similar to metazoan splicing factor U2AF65	mRNA branch site recognition	pre-mRNA branch point binding	commitment complex
YJR019C	YJR019C	TES1	hom	Verified	0.894763027427173	0.185456889206014	no	901	0.18084989860753	584	NA	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM	MITOCHONDRION		Peroxisomal acyl-CoA thioesterase likely to be involved in fatty acid oxidation rather than fatty acid synthesis; conserved protein also found in human peroxisomes; TES1 mRNA levels increase during growth on fatty acids	fatty acid beta-oxidation|fatty acid oxidation	acyl-CoA hydrolase activity	mitochondrion|peroxisome
YIL167W	YIL167W	SDL1	hom	pseudogene	0.894475363269773	0.185533802858267	no	902	0.186765366150501	637	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Open reading frame, unlikely to produce a functional protein in S288C; in closely related species and other <i>S. cerevisiae</i> strain backgrounds YIL167W and adjacent ORF, YIL168W, constitute a single ORF encoding L-serine dehydratase	serine family amino acid metabolic process	L-serine ammonia-lyase activity	cellular_component
YOR087W	YOR087W	YVC1	hom	Verified	0.89412733801736	0.185626881901039	no	903	0.172498505696731	520	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Vacuolar cation channel, mediates release of Ca(2+) from the vacuole in response to hyperosmotic shock	cellular cation homeostasis	voltage-gated ion channel activity|calcium activated cation channel activity|sodium channel activity|calcium channel activity|potassium channel activity	fungal-type vacuole membrane|fungal-type vacuole
YNR068C_p	YNR068C	YNR068C	hom	Uncharacterized	0.894070317478271	0.185642134755262	no	904	0.178065521699468	647	NA					Putative protein of unknown function; exhibits homology to C-terminal end of Bul1p; expressed as a readthrough product of BSC5, the readthrough locus being termed BUL3; the BUL3 readthrough product is involved in ubiquitin-mediated sorting of plasma membrane proteins and interacts with WW domains of Rsp5p in vitro, but in a functionally different way than the non-readthrough form	biological_process	molecular_function	cellular_component
YER173W	YER173W	RAD24	hom	Verified	0.893979568420923	0.185666411508927	no	905	0.194557343808477	606	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Checkpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints; subunit of a clamp loader that loads Rad17p-Mec3p-Ddc1p onto DNA; homolog of human and S. pombe Rad17 protein	reciprocal meiotic recombination|DNA damage checkpoint|nucleotide-excision repair	DNA clamp loader activity	Rad17 RFC-like complex|nucleus
YOR317W	YOR317W	FAA1	hom	Verified	0.89334491816743	0.185836245158513	no	906	0.187620207039482	651	NA	FT	KETONE METABOLISM|LIPID METABOLISM|COFACTOR METABOLISM	MITOCHONDRION		Long chain fatty acyl-CoA synthetase; activates imported fatty acids with a preference for C12:0-C16:0 chain lengths; functions in long chain fatty acid import; accounts for most acyl-CoA synthetase activity; localized to lipid particles; involved in sphingolipid-to-glycerolipid metabolism; forms ER foci upon DNA replication stress; FAA1 has a paralog, FAA4, that arose from the whole genome duplication	long-chain fatty acid transport|long-chain fatty-acyl-CoA metabolic process	long-chain fatty acid-CoA ligase activity	mitochondrial outer membrane|mitochondrion|lipid particle|plasma membrane
YDR350C	YDR350C	ATP22	hom	Verified	0.891988444887204	0.186199562976692	no	907	0.195368602024627	656	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Specific translational activator for the mitochondrial ATP6 mRNA, encoding a subunit of F1F0 ATP synthase; localized to the mitochondrial inner membrane	proton-transporting ATP synthase complex biogenesis|positive regulation of mitochondrial translation	translation regulator activity	mitochondrial inner membrane
YIL123W	YIL123W	SIM1	hom	Verified	0.891426513409147	0.186350199569685	no	908	0.178360488383047	616	NA	FT	CELL WALL ORG/BIOGENESIS			Protein of the SUN family (Sim1p, Uth1p, Nca3p, Sun4p) that may participate in DNA replication, promoter contains SCB regulation box at -300 bp indicating that expression may be cell cycle-regulated	fungal-type cell wall organization	molecular_function	fungal-type cell wall
YLR169W_d	YLR169W	YLR169W	hom	Dubious	0.89124590188009	0.186398632009119	no	909	0.163751862535615	569	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YBR073W	YBR073W	RDH54	hom	Verified	0.891053269778871	0.186450296454402	no	910	0.2091425884451	720	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION	NUCLEUS		DNA-dependent ATPase; stimulates strand exchange by modifying the topology of double-stranded DNA; involved in recombinational repair of DNA double-strand breaks during mitosis and meiosis; proposed to be involved in crossover interference; interacts with Dmc1p; stimulates Dmc1p and Rad51p	DNA geometric change|heteroduplex formation|meiotic sister chromatid segregation|reciprocal meiotic recombination|double-strand break repair via break-induced replication	DNA-dependent ATPase activity|DNA translocase activity	nucleus
YJL162C	YJL162C	JJJ2	hom	Verified	0.890582427977423	0.186576614816619	no	911	0.173271088477896	591	NA	FT		NUCLEUS		Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein	biological_process	molecular_function	nucleus|cytoplasm
YDL048C	YDL048C	STP4	hom	Verified	0.890507053568975	0.186596841330376	no	912	0.197395197738306	665	NA	FT		NUCLEUS|MITOCHONDRION		Protein containing a Kruppel-type zinc-finger domain; has similarity to Stp1p, Stp2p, and Stp3p; predicted to be a transcription factor; relative distribution to the nucleus increases upon DNA replication stress	biological_process	sequence-specific DNA binding	mitochondrion|nucleus|cytoplasm
YOL011W	YOL011W	PLB3	hom	Verified	0.889587243620822	0.186843779151035	no	913	0.165357555702985	569	NA	FT	LIPID METABOLISM	PLASMA MEMBRANE		Phospholipase B (lysophospholipase) involved in phospholipid metabolism; hydrolyzes phosphatidylinositol and phosphatidylserine and displays transacylase activity in vitro	phosphatidylinositol metabolic process|phosphatidylserine catabolic process	lysophospholipase activity	extracellular region|plasma membrane
YGL076C	YGL076C	RPL7A	hom	Verified	0.88945974829719	0.18687802327984	no	914	0.175184258512811	585	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L7A; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2); homologous to mammalian ribosomal protein L7 and bacterial L30; RPL7A has a paralog, RPL7B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit|cytoplasm
YIL117C	YIL117C	PRM5	hom	Verified	0.889154605763573	0.186959997665561	no	915	0.170598855902558	574	NA					Pheromone-regulated protein, predicted to have 1 transmembrane segment; induced during cell integrity signaling	biological_process	molecular_function	integral to membrane
YBR298C	YBR298C	MAL31	hom	Verified	0.888345667451689	0.187177420873285	no	916	0.210912184139866	737	NA	FT	CARBOHYDRATE METABOLISM			Maltose permease, high-affinity maltose transporter (alpha-glucoside transporter); encoded in the MAL3 complex locus; member of the 12 transmembrane domain superfamily of sugar transporters; functional in genomic reference strain S288C	alpha-glucoside transport|transmembrane transport	alpha-glucoside:hydrogen symporter activity	integral to membrane|membrane
YGR067C_p	YGR067C	YGR067C	hom	Uncharacterized	0.888164888611034	0.187226031256591	no	917	0.168495471387768	570	NA	FT		NUCLEUS		Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p	biological_process	sequence-specific DNA binding	cellular_component
YER056C-A	YER056C-A	RPL34A	hom	Verified	0.887448523977954	0.187418734304047	no	918	0.158675211004832	586	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L34A; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34A has a paralog, RPL34B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YGL180W	YGL180W	ATG1	hom	Verified	0.884578761309568	0.188191932888789	no	919	0.179503301297107	610	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|PROTEIN PHOSPHORYLATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS			Protein ser/thr kinase required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; structurally required for phagophore assembly site formation; during autophagy forms a complex with Atg13p and Atg17p	piecemeal microautophagy of nucleus|mitochondrion degradation|protein phosphorylation|CVT pathway|autophagic vacuole assembly	protein serine/threonine kinase activity|protein kinase activity	cytosol|pre-autophagosomal structure|Atg1p signaling complex
YOL018C	YOL018C	TLG2	hom	Verified	0.884253746497451	0.188279625370451	no	920	0.306861531896771	1036	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT	GOLGI APPARATUS		Syntaxin-like t-SNARE that forms a complex with Tlg1p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds Vps45p, which prevents Tlg2p degradation and also facilitates t-SNARE complex formation; homologous to mammalian SNARE protein syntaxin 16 (Sx16)	inositolphosphoceramide metabolic process|Golgi to vacuole transport|endocytosis|mannosyl-inositol phosphorylceramide metabolic process|protein exit from endoplasmic reticulum|vesicle fusion|CVT pathway	SNAP receptor activity	SNARE complex|trans-Golgi network|integral to endosome membrane
YCR043C_p	YCR043C	YCR043C	hom	Uncharacterized	0.883747850991491	0.188416171553721	no	921	0.203607367284535	742	NA	FT		GOLGI APPARATUS|SITE OF POLARIZED GROWTH		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi apparatus; YCR043C is not an essential gene	biological_process	molecular_function	Golgi apparatus|mating projection tip
YCR024C	YCR024C	SLM5	hom	Verified	0.883640819710067	0.188445068177644	no	922	0.213054636452044	750	NA	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial asparaginyl-tRNA synthetase	asparaginyl-tRNA aminoacylation|mitochondrial asparaginyl-tRNA aminoacylation	asparagine-tRNA ligase activity	mitochondrion
YLR260W	YLR260W	LCB5	hom	Verified	0.883335259242209	0.188527579341018	no	923	0.223703829844318	742	NA	FT	LIPID METABOLISM|SIGNALING|PROTEIN PHOSPHORYLATION	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Minor sphingoid long-chain base kinase, paralog of Lcb4p responsible for few percent of the total activity, possibly involved in synthesis of long-chain base phosphates, which function as signaling molecules	response to heat|calcium-mediated signaling|sphingolipid metabolic process	D-erythro-sphingosine kinase activity	Golgi apparatus|membrane
YKR100C	YKR100C	SKG1	hom	Verified	0.883165777278938	0.188573354530836	no	924	0.198234242141819	704	NA	FT	CELL WALL ORG/BIOGENESIS	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Transmembrane protein with a role in cell wall polymer composition; localizes on the inner surface of the plasma membrane at the bud and in the daughter cell	fungal-type cell wall organization	molecular_function	incipient cellular bud site|cellular bud|cellular bud tip
YLL020C_d	YLL020C	YLL020C	hom	Dubious	0.88296584560317	0.188627362658081	no	925	0.167125500530755	556	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene KNS1	Unknown	Unknown	Unknown
YOR248W_d	YOR248W	YOR248W	hom	Dubious	0.882220319733714	0.188828837802558	no	926	0.17819500652241	624	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YLR091W	YLR091W	GEP5	hom	Verified	0.882080393318648	0.18886666708682	no	927	0.21487922406875	725	NA	FT	MITOCHONDRION ORGANIZATION	MITOCHONDRION		Protein of unknown function, required for mitochondrial genome maintenance; detected in highly purified mitochondria in high-throughput studies; null mutant has decreased levels of cardiolipin and phosphatidylethanolamine	mitochondrial genome maintenance	molecular_function	mitochondrion
YPL157W	YPL157W	TGS1	hom	Verified	0.877769804678198	0.190034327000726	no	928	0.182291162552331	649	NA	FT	CELL CYCLE|RNA PROCESSING	NUCLEUS		Trimethyl guanosine synthase, conserved nucleolar methyl transferase that converts the m(7)G cap structure of snRNAs, snoRNAs, and telomerase TLC1 RNA to m(2,2,7)G; also required for nucleolar assembly and splicing of meiotic pre-mRNAs	meiosis|RNA methylation|nucleologenesis|7-methylguanosine cap hypermethylation|regulation of telomere maintenance via telomerase	RNA methyltransferase activity	nucleolus
YOL085C_d	YOL085C	YOL085C	hom	Dubious	0.87525426057703	0.190717787686534	no	929	0.18969806157234	617	NA					Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOL085W-A	Unknown	Unknown	Unknown
YDR430C	YDR430C	CYM1	hom	Verified	0.87516860784436	0.190741085629426	no	930	0.15870276286225	481	NA	FT	PROTEOLYSIS	MITOCHONDRION		Lysine-specific metalloprotease of the mitochondrial intermembrane space, member of the pitrilysin family; degrades proteins and presequence peptides cleaved from imported proteins; required for normal mitochondrial morphology	proteolysis|proteolysis involved in cellular protein catabolic process	metalloendopeptidase activity	mitochondrion|mitochondrial intermembrane space
YKL167C	YKL167C	MRP49	hom	Verified	0.87515635624414	0.190744418264619	no	931	0.196686512566711	642	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit, not essential for mitochondrial translation	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YGR043C	YGR043C	NQM1	hom	Verified	0.873906477433944	0.191084593446491	no	932	0.182357848477147	625	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		Transaldolase of unknown function; transcription is repressed by Mot1p and induced by alpha-factor and during diauxic shift	biological_process	sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity	nucleus
YER086W	YER086W	ILV1	hom	Verified	0.873676493339688	0.191147227920994	no	933	0.227314805368194	777	NA	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		Threonine deaminase, catalyzes the first step in isoleucine biosynthesis; expression is under general amino acid control; ILV1 locus exhibits highly positioned nucleosomes whose organization is independent of known ILV1 regulation	threonine catabolic process|isoleucine biosynthetic process	L-threonine ammonia-lyase activity	mitochondrion
YNR057C	YNR057C	BIO4	hom	Verified	0.871744299749422	0.191673943615234	no	934	0.210609910347373	748	NA	FT	KETONE METABOLISM|COFACTOR METABOLISM			Dethiobiotin synthetase, catalyzes the third step in the biotin biosynthesis pathway; BIO4 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis; expression appears to be repressed at low iron levels	biotin biosynthetic process	dethiobiotin synthase activity	cytoplasm
YGL260W_p	YGL260W	YGL260W	hom	Uncharacterized	0.871555904415875	0.191725347672742	no	935	0.174563191680007	586	NA					Putative protein of unknown function; transcription is significantly increased in a NAP1 deletion background; deletion mutant has increased accumulation of nickel and selenium	biological_process	molecular_function	cellular_component
YAL046C	YAL046C	AIM1	hom	Verified	0.870973572761546	0.191884291440738	no	936	0.201464302506533	695	NA					Protein involved in mitochondrial function or organization; null mutant displays elevated frequency of mitochondrial genome loss	biological_process	molecular_function	cellular_component
YOR253W	YOR253W	NAT5	hom	Verified	0.870349969046576	0.192054589569153	no	937	0.190684876266862	654	NA	FT			RIBOSOME	Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing	N-terminal protein amino acid acetylation	peptide alpha-N-acetyltransferase activity	NatA complex|cytosolic ribosome
YPL086C	YPL086C	ELP3	hom	Verified	0.870003144380849	0.192149342920316	no	938	0.204166259925101	708	NA	FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|RNA PROCESSING|CHROMATIN ORGANIZATION	NUCLEUS		Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; exhibits histone acetyltransferase activity that is directed to histones H3 and H4; disruption confers resistance to K. lactis zymotoxin	regulation of transcription from RNA polymerase II promoter|tRNA wobble uridine modification	histone acetyltransferase activity	Elongator holoenzyme complex|nucleus|cytoplasm
YBR071W	YBR071W	YBR071W	hom	Verified	0.869324862932671	0.192334733722196	no	939	0.180735657925455	588	NA	FT		SITE OF POLARIZED GROWTH		Protein of unknown function found in the cytoplasm and bud neck; mRNA expression may be regulated by the cell cycle and/or cell wall stress; overexpression of YBR071W affects endocytic protein trafficking	biological_process	molecular_function	cellular bud neck|cytoplasm
YLR070C	YLR070C	XYL2	hom	Verified	0.866392902985526	0.193137367273593	no	940	0.198355259882002	650	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM			Xylitol dehydrogenase, converts xylitol to D-xylulose; expression induced by xylose, even though this pentose sugar is not well utilized by S. cerevisiae; null mutant has cell wall defect	xylulose biosynthetic process	D-xylulose reductase activity	cellular_component
YDR131C_p	YDR131C	YDR131C	hom	Uncharacterized	0.866347946858784	0.193149690054593	no	941	0.155985053909261	538	NA	FT	PROTEOLYSIS			F-box protein, substrate-specific adaptor subunit that recruits substrates to a core ubiquitination complex	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	ubiquitin-protein ligase activity|protein binding, bridging	SCF ubiquitin ligase complex
YDR300C	YDR300C	PRO1	hom	Verified	0.86601957189928	0.193239714426969	no	942	0.19772350327824	652	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Gamma-glutamyl kinase; catalyzes the first step in proline biosynthesis; PRO1 has a paralog, YHR033W, that arose from the whole genome duplication	proline biosynthetic process	glutamate 5-kinase activity	cytoplasm
YLR332W	YLR332W	MID2	hom	Verified	0.861450258573137	0.194495052830794	no	943	0.209165825956915	730	NA	FT	RNA PROCESSING|SIGNALING|CELL WALL ORG/BIOGENESIS|PEROXISOME ORGANIZATION	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		O-glycosylated plasma membrane protein that acts as a sensor for cell wall integrity signaling and activates the pathway; interacts with Rom2p, a guanine nucleotide exchange factor for Rho1p, and with cell integrity pathway protein Zeo1p	UFP-specific transcription factor mRNA processing involved in endoplasmic reticulum unfolded protein response|fungal-type cell wall organization|peroxisome degradation|cell morphogenesis involved in conjugation|response to acid|response to osmotic stress	transmembrane signaling receptor activity	integral to plasma membrane|mating projection tip
YNL237W	YNL237W	YTP1	hom	Verified	0.860954252672103	0.194631619733669	no	944	0.260538594166529	914	NA	FF|FT		MITOCHONDRION		Probable type-III integral membrane protein of unknown function, has regions of similarity to mitochondrial electron transport proteins	biological_process	molecular_function	integral to membrane|membrane
YCR087W_d	YCR087W	YCR087W	hom	Dubious	0.857543354028809	0.195572332786205	no	945	0.218350341890063	747	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized gene YCR087C-A; YCR087W is not an essential gene	Unknown	Unknown	Unknown
YMR302C	YMR302C	YME2	hom	Verified	0.857157427830358	0.195678943368109	no	946	0.186527383082249	649	NA	FT	RNA PROCESSING|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Integral inner mitochondrial membrane protein with a role in maintaining mitochondrial nucleoid structure and number; mutants exhibit an increased rate of mitochondrial DNA escape; shows some sequence similarity to exonucleases	mitochondrial genome maintenance	molecular_function	mitochondrion|integral to mitochondrial inner membrane
YOR073W	YOR073W	SGO1	hom	Verified	0.857006982812865	0.195720512763067	no	947	0.212841729376992	711	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME|CYTOSKELETON	KINETOCHORE	Component of the spindle checkpoint, involved in sensing lack of tension on mitotic chromosomes; protects centromeric Rec8p at meiosis I; required for accurate chromosomal segregation at meiosis II and for mitotic chromosome stability	positive regulation of maintenance of meiotic sister chromatid cohesion|meiotic sister chromatid segregation|meiotic sister chromatid separation|sister chromatid biorientation|maintenance of meiotic sister chromatid cohesion|mitotic cell cycle spindle assembly checkpoint|mitotic sister chromatid segregation	molecular_function	condensed nuclear chromosome kinetochore|nucleus|spindle pole body|condensed nuclear chromosome, centromeric region
YOR023C	YOR023C	AHC1	hom	Verified	0.856833955733906	0.195768328424418	no	948	0.178217754986047	623	NA	FT	CHROMATIN ORGANIZATION	NUCLEUS	HISTONE ACETYLTRANSFERASE	Subunit of the Ada histone acetyltransferase complex, required for structural integrity of the complex	histone acetylation	histone acetyltransferase activity	Ada2/Gcn5/Ada3 transcription activator complex
YDL045W-A	YDL045W-A	MRP10	hom	Verified	0.856584607848385	0.195837247646293	no	949	0.232796691918993	787	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the small subunit; contains twin cysteine-x9-cysteine motifs	mitochondrial translation|mitochondrial respiratory chain complex assembly	structural constituent of ribosome	mitochondrial small ribosomal subunit
YOR380W	YOR380W	RDR1	hom	Verified	0.854756230968519	0.196343056782792	no	950	0.190443111185169	635	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Transcriptional repressor involved in the control of multidrug resistance; negatively regulates expression of the PDR5 gene; member of the Gal4p family of zinc cluster proteins	response to xenobiotic stimulus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	nucleus
YOL145C	YOL145C	CTR9	hom	Verified	0.854538659128165	0.196403299364226	no	951	0.246897334545268	878	NA	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION|GENE SILENCING	NUCLEUS|CHROMOSOME	RNA POL II, HOLOENZYME	Component of the Paf1p complex involved in transcription elongation; binds to and modulates the activity of RNA polymerases I and II; required for expression of a subset of genes, including cyclin genes; involved in SER3 repression by helping to maintain SRG1 transcription-dependent nucleosome occupancy; contains TPR repeats	transcription elongation from RNA polymerase I promoter|mRNA 3'-end processing|regulation of chromatin silencing at telomere|snoRNA transcription from an RNA polymerase II promoter|regulation of transcription by chromatin organization|transcription from RNA polymerase I promoter|regulation of histone H3-K4 methylation|regulation of transcription-coupled nucleotide-excision repair|regulation of transcription initiation from RNA polymerase II promoter|snoRNA 3'-end processing|Unknown|regulation of transcription involved in G1 phase of mitotic cell cycle|transcription elongation from RNA polymerase II promoter	RNA polymerase II core binding|triplex DNA binding|RNA polymerase II transcription factor binding transcription factor activity	transcriptionally active chromatin|nucleus|Cdc73/Paf1 complex
YJR115W_p	YJR115W	YJR115W	hom	Uncharacterized	0.853066107377553	0.196811322650559	no	952	0.17625135001194	594	NA					Putative protein of unknown function; YJR115W has a paralog, ECM13, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YDR337W	YDR337W	MRPS28	hom	Verified	0.851846783029235	0.197149568374697	no	953	0.22447918083767	753	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the small subunit	mitochondrial translation	structural constituent of ribosome|RNA binding	mitochondrion|mitochondrial small ribosomal subunit
YLR172C	YLR172C	DPH5	hom	Verified	0.8517456466473	0.197177639823221	no	954	0.209704569454165	711	NA					Methyltransferase required for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); not essential for viability; GFP-Dph5p fusion protein localizes to the cytoplasm	peptidyl-diphthamide biosynthetic process from peptidyl-histidine	diphthine synthase activity	cytoplasm
YLL045C	YLL045C	RPL8B	hom	Verified	0.851462870020832	0.197256140232592	no	955	0.181420631454195	618	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L8B; mutation results in decreased amounts of free 60S subunits; homologous to mammalian ribosomal protein L7A, no bacterial homolog; RPL8B has a paralog, RPL8A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YCL049C_p	YCL049C	YCL049C	hom	Uncharacterized	0.851098635968496	0.197357281544521	no	956	0.197505647342463	688	NA					Protein of unknown function; localizes to membrane fraction; YCL049C is not an essential gene	biological_process	molecular_function	membrane
YGR139W_d	YGR139W	YGR139W	hom	Dubious	0.851010215414671	0.197381839088585	no	957	0.165732019919686	570	NA					Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YIR039C	YIR039C	YPS6	hom	Verified	0.850027781596297	0.197654820349995	no	958	0.221531093240265	775	NA	FT	CELL WALL ORG/BIOGENESIS|PROTEOLYSIS	PLASMA MEMBRANE		Putative GPI-anchored aspartic protease, member of the yapsin family of proteases involved in cell wall growth and maintenance	fungal-type cell wall organization	aspartic-type endopeptidase activity	fungal-type cell wall
YAL037W_p	YAL037W	YAL037W	hom	Uncharacterized	0.849799165207499	0.197718376924788	no	959	0.208226543363237	715	NA					Putative protein of unknown function; YAL037W has a paralog, YOR342C, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YIL086C_d	YIL086C	YIL086C	hom	Dubious	0.848362822971704	0.198117970201873	no	960	0.181169912000007	606	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YGL038C	YGL038C	OCH1	hom	Verified	0.848233742429797	0.198153904529638	no	961	0.251215417705373	883	NA	FT	CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Mannosyltransferase of the cis-Golgi apparatus, initiates the polymannose outer chain elongation of N-linked oligosaccharides of glycoproteins	protein N-linked glycosylation	alpha-1,6-mannosyltransferase activity|transferase activity, transferring glycosyl groups	Golgi cis cisterna
YNR071C_p	YNR071C	YNR071C	hom	Uncharacterized	0.844671648203852	0.199147096680573	no	962	0.191028368819872	639	NA	FT	CARBOHYDRATE METABOLISM			Putative aldose 1-epimerase	biological_process	molecular_function	cellular_component
YCR084C	YCR084C	TUP1	hom	Verified	0.844137651960194	0.199296244913226	no	963	0.191721550666806	687	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|LIPID METABOLISM|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		General repressor of transcription, forms complex with Cyc8p, involved in the establishment of repressive chromatin structure through interactions with histones H3 and H4, appears to enhance expression of some genes	nucleosome positioning|regulation of transcription from RNA polymerase II promoter in response to osmotic stress|histone exchange|negative regulation of mating-type specific transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter by glucose|negative regulation of dipeptide transport by negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter in response to hypoxia|negative regulation of transcription from RNA polymerase II promoter during mitosis|Unknown	ubiquitin binding|histone deacetylase binding|histone binding|phosphatidylinositol-3,5-bisphosphate binding|RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription|mediator complex binding	nucleus|transcriptional repressor complex
YPL256C	YPL256C	CLN2	hom	Verified	0.842619957946789	0.199720512730442	no	964	0.187525123947362	635	NA	FT	CELL CYCLE|SIGNALING|CELL DIVISION|PROTEIN PHOSPHORYLATION	NUCLEUS		G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p)	regulation of cyclin-dependent protein kinase activity|re-entry into mitotic cell cycle after pheromone arrest	cyclin-dependent protein kinase regulator activity	cyclin-dependent protein kinase holoenzyme complex|nucleus|cytoplasm
YGR007W	YGR007W	ECT1	hom	Verified	0.842415386007128	0.199777741867012	no	965	0.205921364657537	678	NA	FT	LIPID METABOLISM	NUCLEUS		Ethanolamine-phosphate cytidylyltransferase, catalyzes the second step of phosphatidylethanolamine biosynthesis; involved in the maintenance of plasma membrane; similar to mammalian CTP: phosphocholine cytidylyl-transferases	phosphatidylethanolamine biosynthetic process	ethanolamine-phosphate cytidylyltransferase activity	nucleus|cytoplasm
YGL167C	YGL167C	PMR1	hom	Verified	0.841348739402097	0.200076296738911	no	966	0.246446678689317	846	NA	FT	VESICLE-MEDIATED TRANSPORT|ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		High affinity Ca2+/Mn2+ P-type ATPase required for Ca2+ and Mn2+ transport into Golgi; involved in Ca2+ dependent protein sorting and processing; mutations in human homolog ATP2C1 cause acantholytic skin condition Hailey-Hailey disease	manganese ion transport|calcium ion transport|exocytosis	manganese-transporting ATPase activity|calcium-transporting ATPase activity|calcium ion binding	integral to membrane|Golgi membrane
YHR043C	YHR043C	DOG2	hom	Verified	0.840407302608143	0.200340028029303	no	967	0.19948554658085	636	NA	FT	CARBOHYDRATE METABOLISM	NUCLEUS		2-deoxyglucose-6-phosphate phosphatase; member of a family of low molecular weight phosphatases, paralogous to DOG1, induced by oxidative and osmotic stress, confers 2-deoxyglucose resistance when overexpressed	glucose metabolic process	2-deoxyglucose-6-phosphatase activity	nucleus|cytoplasm
YKL164C	YKL164C	PIR1	hom	Verified	0.840273941839116	0.200377404197632	no	968	0.189654431543661	616	NA	FT	PROTEIN LOCALIZATION|CELL WALL ORG/BIOGENESIS			O-glycosylated protein required for cell wall stability; attached to the cell wall via beta-1,3-glucan; mediates mitochondrial translocation of Apn1p; expression regulated by the cell integrity pathway and by Swi5p during the cell cycle; PIR1 has a paralog, YJL160C, that arose from the whole genome duplication	intracellular protein transport|fungal-type cell wall organization	structural constituent of cell wall	fungal-type cell wall
YMR082C_d	YMR082C	YMR082C	hom	Dubious	0.839846167139898	0.200497322137001	no	969	0.218580206337837	688	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDR392W	YDR392W	SPT3	hom	Verified	0.839625464568477	0.200559208466701	no	970	0.25993886099626	904	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION	NUCLEUS	HISTONE ACETYLTRANSFERASE	Subunit of the SAGA and SAGA-like transcriptional regulatory complexes, interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes, also functions to inhibit transcription at some promoters	conjugation with cellular fusion|histone acetylation|pseudohyphal growth|ascospore formation|chromatin modification|invasive growth in response to glucose limitation|transcription from RNA polymerase II promoter	transcription cofactor activity	SLIK (SAGA-like) complex|SAGA complex
YGL159W_p	YGL159W	YGL159W	hom	Uncharacterized	0.837549738288054	0.20114181567493	no	971	0.217292951946313	768	NA					Putative protein of unknown function; deletion mutant has no detectable phenotype	biological_process	molecular_function	cellular_component
YMR110C	YMR110C	HFD1	hom	Verified	0.837331335828214	0.201203175030003	no	972	0.176413270161184	606	NA	FT	OXIDATION-REDUCTION PROCESS	MITOCHONDRION		Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; located in the mitochondrial outer membrane and also in lipid particles; has similarity to ALDH3A2, a human fatty aldehyde dehydrogenase (FALDH) mutated in Sjogren-Larsson syndrome, a neurocutaneous disorder	cellular aldehyde metabolic process	3-chloroallyl aldehyde dehydrogenase activity	mitochondrial outer membrane|endosome|mitochondrion|lipid particle|integral to mitochondrial outer membrane
YKL064W	YKL064W	MNR2	hom	Verified	0.837276917322569	0.201218465452318	no	973	0.193317398200668	666	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Vacuolar membrane protein required for magnesium homeostasis; putative magnesium transporter; has similarity to Alr1p and Alr2p, which mediate influx of Mg2+ and other divalent cations	cellular magnesium ion homeostasis	magnesium ion transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane
YOR090C	YOR090C	PTC5	hom	Verified	0.836508862835951	0.201434346441849	no	974	0.206720781989722	650	NA	FT		MITOCHONDRION		Mitochondrial type 2C protein phosphatase (PP2C) involved in regulation of pyruvate dehydrogenase activity by dephosphorylating the serine 133 of the Pda1p subunit; localizes to the intermembrane space and is imported via the presequence pathway and processed by the inner membrane protease (Imp1p-Imp2p); acts in concert with kinases Pkp1p and Pkp2p and phosphatase Ptc6p	positive regulation of catalytic activity|regulation of catalytic activity|protein dephosphorylation	[pyruvate dehydrogenase (lipoamide)] phosphatase activity|protein serine/threonine phosphatase activity	mitochondrion
YKR094C	YKR094C	RPL40B	hom	Verified	0.836225807905418	0.201513941124168	no	975	0.1947369619306	685	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RESPONSE TO DNA DAMAGE|TRANSLATION	NUCLEUS|MITOCHONDRION	RIBOSOME	Ubiquitin-ribosomal 60S subunit protein L40B fusion protein; cleaved to yield ubiquitin and ribosomal protein L40B; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; homologous to mammalian ribosomal protein L40, no bacterial homolog; RPL40B has a paralog, RPL40A, that arose from the whole genome duplication	cytoplasmic translation|protein ubiquitination|ribosome biogenesis	structural constituent of ribosome|protein tag	mitochondrion|cytosolic large ribosomal subunit
YDR009W	YDR009W	GAL3	hom	Verified	0.834141645344773	0.202100584962939	no	976	0.175658139085244	599	NA	FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Transcriptional regulator; involved in activation of the GAL genes in response to galactose; forms a complex with Gal80p to relieve Gal80p inhibition of Gal4p; binds galactose and ATP but does not have galactokinase activity; GAL3 has a paralog, GAL1, that arose from the whole genome duplication	maintenance of protein location|galactose metabolic process|positive regulation of transcription from RNA polymerase II promoter by galactose	protein binding	nucleus|cytoplasm
YPR083W	YPR083W	MDM36	hom	Verified	0.834117271723101	0.202107451617049	no	977	0.209134217507076	683	NA	FT	MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial protein required for normal mitochondrial morphology and inheritance; proposed involvement in the formation of Dnm1p and Num1p-containing cortical anchor complexes that promote mitochondrial fission	mitochondrial fission|mitochondrion organization	molecular_function	mitochondrion|cytoplasm
YGR178C	YGR178C	PBP1	hom	Verified	0.831665044307185	0.202799018307324	no	978	0.213929073358716	771	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|TRANSLATION	NUCLEUS|MITOCHONDRION		Component of glucose deprivation induced stress granules; involved in P-body-dependent granule assembly; similar to human ataxin-2; interacts with Pab1p to regulate mRNA polyadenylation; interacts with Mkt1p to regulate HO translation; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress	positive regulation of translation|mRNA polyadenylation|stress granule assembly	molecular_function	mitochondrion|nucleus|polysome|cytoplasmic stress granule|cytoplasm
YIL173W	YIL173W	VTH1	hom	Verified	0.829915122952153	0.203293386946313	no	979	0.172850373002969	579	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	GOLGI APPARATUS		Putative membrane glycoprotein with strong similarity to Vth2p and Pep1p/Vps10p, may be involved in vacuolar protein sorting	Golgi to vacuole transport	signal sequence binding	endosome|integral to membrane
YDR277C	YDR277C	MTH1	hom	Verified	0.829757755725668	0.203337879832024	no	980	0.19535275992882	596	NA	FT	SIGNALING			Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation	glucose transport|signal transduction	molecular_function	cellular_component
YCR107W	YCR107W	AAD3	hom	Verified	0.82940353482904	0.203438050975905	no	981	0.222689591903593	770	NA	FT	OXIDATION-REDUCTION PROCESS			Putative aryl-alcohol dehydrogenase; similar to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role	cellular aldehyde metabolic process	aryl-alcohol dehydrogenase (NAD+) activity	cellular_component
YLR398C	YLR398C	SKI2	hom	Verified	0.828982495063447	0.203557156305085	no	982	0.21013843159979	698	NA	FT	TRANSLATION			Ski complex component and putative RNA helicase, mediates 3'-5' RNA degradation by the cytoplasmic exosome; null mutants have superkiller phenotype of increased viral dsRNAs and are synthetic lethal with mutations in 5'-3' mRNA decay	nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'|nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay|nuclear-transcribed mRNA catabolic process, non-stop decay	RNA helicase activity	Ski complex
YDL010W	YDL010W	GRX6	hom	Verified	0.826945263304665	0.204134043361238	no	983	0.199710293419053	630	NA	FT	RESPONSE TO OXIDATIVE STRESS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Cis-golgi localized monothiol glutaredoxin, binds Fe-S cluster; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; GRX6 has a paralog, GRX7, that arose from the whole genome duplication	cellular response to oxidative stress	glutathione-disulfide reductase activity|iron ion binding|protein homodimerization activity|2 iron, 2 sulfur cluster binding	integral to membrane|Golgi apparatus|Golgi lumen|endoplasmic reticulum membrane|fungal-type vacuole|cis-Golgi network
YJR087W_d	YJR087W	YJR087W	hom	Dubious	0.825393252048105	0.204574182353012	no	984	0.197111630319925	703	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified genes STE18 and ECM2	Unknown	Unknown	Unknown
YPL191C_p	YPL191C	YPL191C	hom	Uncharacterized	0.824991355483297	0.204688249245166	no	985	0.197906071376465	680	NA					Putative protein of unknown function; diploid deletion strain exhibits high budding index; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	biological_process	molecular_function	cytoplasm
YML038C	YML038C	YMD8	hom	Verified	0.823717094048184	0.205050162126783	no	986	0.207208153844553	669	NA	FT		ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Putative nucleotide sugar transporter, has similarity to Vrg4p	UDP-glucose transport|nucleotide-sugar transport	nucleotide-sugar transmembrane transporter activity	COPI-coated vesicle|integral to membrane
YOL052C	YOL052C	SPE2	hom	Verified	0.823637528633359	0.20507277272675	no	987	0.220058952028852	709	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM	NUCLEUS		S-adenosylmethionine decarboxylase, required for the biosynthesis of spermidine and spermine; cells lacking Spe2p require spermine or spermidine for growth in the presence of oxygen but not when grown anaerobically	spermidine biosynthetic process|spermine biosynthetic process|pantothenate biosynthetic process	adenosylmethionine decarboxylase activity	nucleus|cytoplasm
YMR070W	YMR070W	MOT3	hom	Verified	0.821409645618531	0.205706485597798	no	988	0.238913125825293	831	NA	FT	TRANSCRIPTION FROM RNA POL II|LIPID METABOLISM	NUCLEUS		Transcriptional repressor and activator with two C2-H2 zinc fingers; involved in repression of a subset of hypoxic genes by Rox1p, repression of several DAN/TIR genes during aerobic growth, and repression of ergosterol biosynthetic genes in response to hyperosmotic stress; contributes to recruitment of the Tup1p-Cyc8p general repressor to promoters; involved in positive transcriptional regulation of CWP2 and other genes; can form the [MOT3+] prion	cellular hyperosmotic response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of ergosterol biosynthetic process|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II repressing transcription factor binding|RNA polymerase II activating transcription factor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding	nucleus
YIR019C	YIR019C	FLO11	hom	Verified	0.819448227804639	0.206265364300297	no	989	0.186467501371227	645	NA	FT		SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		GPI-anchored cell surface glycoprotein (flocculin); required for pseudohyphal formation, invasive growth, flocculation, and biofilms; transcriptionally regulated by the MAPK pathway (via Ste12p and Tec1p) and the cAMP pathway (via Flo8p); required for the formation of fibrous interconnections between cells in a colony of a wild S. cerevisiae strain	cell-cell adhesion|biofilm formation|pseudohyphal growth|filamentous growth|flocculation|invasive growth in response to glucose limitation	molecular_function	extracellular region|plasma membrane|cellular bud neck
YBR025C	YBR025C	OLA1	hom	Verified	0.819351088219612	0.206293066242654	no	990	0.209492297264621	716	NA					P-loop ATPase with similarity to human OLA1 and bacterial YchF; identified as specifically interacting with the proteasome; protein abundance increases in response to hydrogen peroxide and to DNA replication stress	biological_process	ATPase activity	cytoplasm
YBR297W	YBR297W	MAL33	hom	Verified	0.8192073514734	0.206334060652887	no	991	0.206979375490942	726	NA	FT	TRANSCRIPTION FROM RNA POL II|CARBOHYDRATE METABOLISM	NUCLEUS		MAL-activator protein, part of complex locus MAL3; nonfunctional in genomic reference strain S288C	cellular carbohydrate metabolic process|regulation of transcription, DNA-dependent	sequence-specific DNA binding transcription factor activity	nucleus
YNL138W	YNL138W	SRV2	hom	Verified	0.818936616464945	0.20641128868661	no	992	0.270854747050578	923	NA	FT	SIGNALING|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		CAP (cyclase-associated protein) subunit of adenylyl cyclase complex; N-terminus binds adenylyl cyclase and facilitates activation by RAS; C-terminus binds ADP-actin monomers, facilitating regulation of actin dynamics and cell morphogenesis	cytoskeleton organization|Ras protein signal transduction	cytoskeletal protein binding|adenylate cyclase binding	mating projection tip|actin cortical patch
YBR239C_p	YBR239C	ERT1	hom	Uncharacterized	0.818814642650876	0.206446087705764	no	993	0.198700213122052	648	NA	FT	TRANSCRIPTION FROM RNA POL II|SIGNALING|CARBOHYDRATE METABOLISM	NUCLEUS		Transcriptional regulator of nonfermentable carbon utilization; GFP-fusion protein localizes to cytoplasm, nucleus; null mutation affects periodicity of transcriptional and metabolic oscillation; plays role in restricting Ty1 transposition	biological_process	sequence-specific DNA binding	nucleus|cytoplasm
YNL012W	YNL012W	SPO1	hom	Verified	0.818188449796629	0.206624794683454	no	994	0.181085972457565	616	NA	FT	CELL CYCLE|LIPID METABOLISM|MEMBRANE ORGANIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM		Meiosis-specific prospore protein; required for meiotic spindle pole body duplication and separation; required to produce bending force necessary for proper prospore membrane assembly during sporulation; has similarity to phospholipase B	meiosis|spore membrane bending pathway	phospholipase activity	endoplasmic reticulum|nucleus|prospore membrane
YER041W	YER041W	YEN1	hom	Verified	0.817926697318846	0.206699522446594	no	995	0.199991252071209	713	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		Holliday junction resolvase; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1 and has similarity to S. cerevisiae endonuclease Rth1p	DNA repair|response to DNA damage stimulus	single-stranded DNA specific endodeoxyribonuclease activity|crossover junction endodeoxyribonuclease activity	nucleus|cytoplasm
YHL008C_p	YHL008C	YHL008C	hom	Uncharacterized	0.817026765457004	0.206956566222285	no	996	0.204423620183184	705	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Putative protein of unknown function, may be involved in the uptake of chloride ions; does not appear to be involved in monocarboxylic acid transport; green fluorescent protein (GFP)-fusion protein localizes to the vacuole	chloride transport|monocarboxylic acid transport	monocarboxylic acid transmembrane transporter activity|transporter activity	integral to membrane|fungal-type vacuole
YDR203W_d	YDR203W	YDR203W	hom	Dubious	0.816657329011972	0.207062141551889	no	997	0.247011999764442	861	NA	FF				Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YKR029C	YKR029C	SET3	hom	Verified	0.816154327336257	0.207205937566009	no	998	0.212160058086338	732	NA	FT	CELL CYCLE|CHROMATIN ORGANIZATION	NUCLEUS|CHROMOSOME		Defining member of the SET3 histone deacetylase complex which is a meiosis-specific repressor of sporulation genes; necessary for efficient transcription by RNAPII; one of two yeast proteins that contains both SET and PHD domains; SET3 has a paralog, SET4, that arose from the whole genome duplication	negative regulation of meiosis|regulation of transcription, DNA-dependent|histone deacetylation	methylated histone residue binding	Rpd3L-Expanded complex|Set3 complex
YPL114W_d	YPL114W	YPL114W	hom	Dubious	0.814024951631632	0.207815328483554	no	999	0.19944488333031	713	NA					Dubious open reading frame, unlikely to encode a functional protein; largely overlaps ORF YPL113C; diploid deletion in BY4743 strain background exhibits high budding index	Unknown	Unknown	Unknown
YNL288W	YNL288W	CAF40	hom	Verified	0.813183797139161	0.208056343866677	no	1000	0.212397553661498	716	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Evolutionarily conserved subunit of the CCR4-NOT complex involved in controlling mRNA initiation, elongation and degradation; binds Cdc39p	positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter	molecular_function	CCR4-NOT core complex
YPR017C	YPR017C	DSS4	hom	Verified	0.813050810184313	0.208094463620901	no	1001	0.218749508656856	771	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING			Guanine nucleotide dissociation stimulator for Sec4p, functions in the post-Golgi secretory pathway; binds zinc, found both on membranes and in the cytosol	post-Golgi vesicle-mediated transport	zinc ion binding|guanyl-nucleotide exchange factor activity	cytosol|membrane
YCL034W	YCL034W	LSB5	hom	Verified	0.812352113499608	0.20829480771274	no	1002	0.229891972277611	767	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION	CYTOSKELETON		Protein of unknown function; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; may mediate disassembly of the Pan1 complex from the endocytic coat	endocytosis|actin filament organization|actin cortical patch localization|actin cytoskeleton organization	molecular_function	cell cortex|cytoplasm|actin cortical patch
YGR026W_p	YGR026W	YGR026W	hom	Uncharacterized	0.812322520147262	0.208303295813413	no	1003	0.215727105579541	702	NA	FT		PLASMA MEMBRANE		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery	biological_process	molecular_function	integral to membrane
YOR273C	YOR273C	TPO4	hom	Verified	0.812322110408276	0.208303413338055	no	1004	0.286011636571708	993	NA	FF|FT		PLASMA MEMBRANE		Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; recognizes spermine, putrescine, and spermidine; localizes to the plasma membrane	spermidine transport|spermine transport	spermidine transmembrane transporter activity|spermine transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane|plasma membrane
YJR011C_p	YJR011C	YJR011C	hom	Uncharacterized	0.812132979155094	0.208357665666349	no	1005	0.194802037987292	628	NA					Putative protein of unknown function; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS	biological_process	molecular_function	cellular_component
YPL267W	YPL267W	ACM1	hom	Verified	0.81179744316667	0.208453934721755	no	1006	0.217382718895106	764	NA	FT	CELL CYCLE|CELL DIVISION	NUCLEUS		Pseudosubstrate inhibitor of the anaphase-promoting complex/cyclosome (APC/C), that suppresses APC/C [Cdh1]-mediated proteolysis of mitotic cyclins; associates with Cdh1p, Bmh1p and Bmh2p; cell cycle regulated protein	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	ubiquitin-protein ligase inhibitor activity	nucleus|cytoplasm
YGR020C	YGR020C	VMA7	hom	Verified	0.811506216543998	0.208537512180817	no	1007	0.258564830474429	918	NA	FF|FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Subunit F of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane	vacuolar acidification	proton-transporting ATPase activity, rotational mechanism	fungal-type vacuole membrane|vacuolar proton-transporting V-type ATPase, V1 domain|integral to membrane
YOR120W	YOR120W	GCY1	hom	Verified	0.810082122635272	0.208946489165406	no	1008	0.24610693665743	829	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		Glycerol dehydrogenase;involved in an alternative pathway for glycerol catabolism used under microaerobic conditions; also has mRNA binding activity; member of the aldo-keto reductase (AKR) family; protein abundance increases in response to DNA replication stress; GCY1 has a paralog, YPR1, that arose from the whole genome duplication	cellular response to oxidative stress|arabinose catabolic process|D-xylose catabolic process	oxidoreductase activity|mRNA binding|alditol:NADP+ 1-oxidoreductase activity|aldo-keto reductase (NADP) activity	nucleus|cytoplasm
YJL209W	YJL209W	CBP1	hom	Verified	0.808884158848599	0.209290890799973	no	1009	0.201085230484966	707	NA	FT	RNA PROCESSING|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Mitochondrial protein, regulator of COB mRNA stability and translation; interacts with the 5'-untranslated region of the COB mRNA; found in a complex at the inner membrane along with Pet309p; localizes to mitochondrial foci upon DNA replication stress	mitochondrial mRNA catabolic process|aerobic respiration	mRNA binding	mitochondrion|extrinsic to mitochondrial inner membrane
YOR067C	YOR067C	ALG8	hom	Verified	0.808003296819648	0.209544342134769	no	1010	0.252335573448574	890	NA	FF|FT	LIPID METABOLISM|CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Glucosyl transferase, involved in N-linked glycosylation; adds glucose to the dolichol-linked oligosaccharide precursor prior to transfer to protein during lipid-linked oligosaccharide biosynthesis; similar to Alg6p	oligosaccharide-lipid intermediate biosynthetic process|protein N-linked glycosylation	dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity	integral to membrane|endoplasmic reticulum membrane
YOR227W	YOR227W	HER1	hom	Verified	0.80778039155103	0.209608507509252	no	1011	0.218216842061688	739	NA	FT		MITOCHONDRION		Protein of unknown function required for proliferation or remodeling of the ER that is caused by overexpression of Hmg2p; may interact with ribosomes, based on co-purification experiments; HER1 has a paralog, GIP3, that arose from the whole genome duplication	endoplasmic reticulum organization	molecular_function	mitochondrion|ribosome|cytoplasm
YGL181W	YGL181W	GTS1	hom	Verified	0.805764253846863	0.210189396428591	no	1012	0.214702517255667	696	NA	FT	VESICLE-MEDIATED TRANSPORT|TRANSCRIPTION FROM RNA POL II|LIPID METABOLISM|MEMBRANE ORGANIZATION|SIGNALING|NUCLEOTIDE METABOLISM	NUCLEUS|CYTOSKELETON		Protein involved in Arf3p regulation and in transcription regulation; localizes to the nucleus and to endocytic patches; contains an N-terminal Zn-finger and ArfGAP homology domain, a C-terminal glutamine-rich region, and a UBA (ubiquitin associated) domain; gts1 mutations affect budding, cell size, heat tolerance, sporulation, life span, ultradian rhythms, endocytosis; expression oscillates in a pattern similar to metabolic oscillations	endocytosis|ultradian rhythm|regulation of transcription from RNA polymerase II promoter|negative regulation of phosphatidylinositol biosynthetic process|positive regulation of transcription from RNA polymerase II promoter	ARF GTPase activator activity|repressing transcription factor binding|transcription factor binding transcription factor activity	nucleus|cytoplasm|actin cortical patch
YMR219W	YMR219W	ESC1	hom	Verified	0.805093132033115	0.210382969376189	no	1013	0.226009163347854	759	NA	FT	GENE SILENCING	NUCLEUS		Protein localized to the nuclear periphery, involved in telomeric silencing; interacts with PAD4-domain of Sir4p	chromatin silencing at telomere	molecular_function	nuclear periphery
YGL085W_p	YGL085W	LCL3	hom	Uncharacterized	0.804376778780643	0.210589703946144	no	1014	0.196015794517095	712	NA	FT		MITOCHONDRION		Putative protein of unknown function; mutant has long chronological lifespan; has homology to Staphylococcus aureus nuclease; GFP-fusion protein localizes to mitochondria; is induced in response to the DNA-damaging agent MMS	biological_process	molecular_function	mitochondrion
YJR074W	YJR074W	MOG1	hom	Verified	0.802358986791107	0.21117266509679	no	1015	0.213100945465284	755	NA	FT	PROTEIN LOCALIZATION|RNA LOCALIZATION	NUCLEUS		Conserved nuclear protein that interacts with GTP-Gsp1p, which is a Ran homolog of the Ras GTPase family, and stimulates nucleotide release, involved in nuclear protein import, nucleotide release is inhibited by Yrb1p	protein import into nucleus	Ran GTPase binding	nucleus
YPR120C	YPR120C	CLB5	hom	Verified	0.802201484301711	0.211218208962455	no	1016	0.231153885671698	775	NA	FT	CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION	NUCLEUS		B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1 phase	spindle assembly|G1/S transition of mitotic cell cycle|regulation of S phase of mitotic cell cycle|G2/M transition of mitotic cell cycle|regulation of cyclin-dependent protein kinase activity|positive regulation of spindle pole body separation|premeiotic DNA replication|positive regulation of DNA replication	cyclin-dependent protein kinase regulator activity	nucleus
YLR385C	YLR385C	SWC7	hom	Verified	0.802135867813418	0.211237184510106	no	1017	0.203706225944337	674	NA	FT	CHROMATIN ORGANIZATION	NUCLEUS|CHROMOSOME		Protein of unknown function, component of the Swr1p complex that incorporates Htz1p into chromatin	chromatin remodeling	molecular_function	Swr1 complex|nucleus
YDR450W	YDR450W	RPS18A	hom	Verified	0.799239818705135	0.212075683637715	no	1018	0.225154428510024	759	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION	MITOCHONDRION	RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S18 and bacterial S13; RPS18A has a paralog, RPS18B, that arose from the whole genome duplication; protein increases in abundance and relocalizes from cytoplasm to nuclear foci upon DNA replication stress	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|cytoplasmic translation|rRNA export from nucleus	structural constituent of ribosome	cytosolic small ribosomal subunit|mitochondrion
YHR140W_p	YHR140W	YHR140W	hom	Uncharacterized	0.799103058708536	0.212115328109468	no	1019	0.190171197597548	660	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Putative integral membrane protein of unknown function	biological_process	molecular_function	integral to membrane
YEL018W	YEL018W	EAF5	hom	Verified	0.798037639903612	0.212424323819425	no	1020	0.229036217568936	789	NA	FT	CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE	NUCLEUS	HISTONE ACETYLTRANSFERASE	Esa1p-associated factor, non-essential subunit of the NuA4 acetyltransferase complex	DNA repair	molecular_function	nucleus|NuA4 histone acetyltransferase complex
YFR030W	YFR030W	MET10	hom	Verified	0.796967446096819	0.212734968991579	no	1021	0.212942919247206	724	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY			Subunit alpha of assimilatory sulfite reductase, which converts sulfite into sulfide	sulfate assimilation	sulfite reductase (NADPH) activity	sulfite reductase complex (NADPH)
YMR140W	YMR140W	SIP5	hom	Verified	0.794004426831925	0.213596427113632	no	1022	0.200288425843145	689	NA	FT	RESPONSE TO NUTRIENT LEVELS			Protein of unknown function; interacts with both the Reg1p/Glc7p phosphatase and the Snf1p kinase; forms cytoplasmic foci upon DNA replication stress	cellular response to glucose starvation	molecular_function	cytoplasm
YJR060W	YJR060W	CBF1	hom	Verified	0.793294380452035	0.213803165066424	no	1023	0.238722597951921	820	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|LIPID METABOLISM|AMINO ACID METABOLISM|CHROMATIN ORGANIZATION|RESPONSE TO NUTRIENT LEVELS|CHROMOSOME SEGREGATION	NUCLEUS|MITOCHONDRION|CHROMOSOME	KINETOCHORE	Dual function helix-loop-helix protein; binds the motif CACRTG present at several sites including MET gene promoters and centromere DNA element I (CDEI); affects nucleosome positioning at this motif; associates with other transcription factors such as Met4p and Isw1p to mediate transcriptional activation or repression; associates with kinetochore proteins and required for efficient chromosome segregation; protein abundance increases in response to DNA replication stress	regulation of transcription from RNA polymerase II promoter in response to methionine|negative regulation of transcription from RNA polymerase II promoter|methionine biosynthetic process|chromosome segregation|Unknown|chromatin remodeling|negative regulation of ceramide biosynthetic process by negative regulation of transcription from RNA Polymerase II promoter	RNA polymerase II activating transcription factor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II transcription factor binding transcription factor activity|RNA polymerase II repressing transcription factor binding|centromeric DNA binding	chromosome, centromeric region|mitochondrion|nucleus|kinetochore
YGL072C_d	YGL072C	YGL072C	hom	Dubious	0.793057710768454	0.213872099979804	no	1024	0.24924539677937	889	NA	FF				Dubious open reading frame unlikely to encode a protein; partially overlaps the verified gene HSF1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2	Unknown	Unknown	Unknown
YER111C	YER111C	SWI4	hom	Verified	0.792845664943235	0.213933873678379	no	1025	0.211847022493755	745	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE	NUCLEUS|CHROMOSOME		DNA binding component of the SBF complex (Swi4p-Swi6p); a transcriptional activator that in concert with MBF (Mbp1-Swi6p) regulates late G1-specific transcription of targets including cyclins and genes required for DNA synthesis and repair; acetylation at two sites, K1016 and K1066, regulates interaction with Swi6p	positive regulation of transcription from RNA polymerase II promoter in response to heat stress|positive regulation of transcription involved in G1/S phase of mitotic cell cycle	sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	SBF transcription complex|nuclear chromatin
YBR270C_p	YBR270C	BIT2	hom	Uncharacterized	0.791236195077052	0.214403086825772	no	1026	0.189699421121319	632	NA					Subunit of TORC2 membrane-associated complex; involved in regulation of actin cytoskeletal dynamics during polarized growth and cell wall integrity; interacts with Slm1p and Slm2p, homologous PH domain-containing TORC2 substrates; BIT2 has a paralog, BIT61, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YBR200W-A_p	YBR200W-A	YBR200W-A	hom	Uncharacterized	0.789508993838397	0.214907287623771	no	1027	0.234570829393982	800	NA					Putative protein of unknown function; identified by fungal homology and RT-PCR	biological_process	molecular_function	cellular_component
YHL025W	YHL025W	SNF6	hom	Verified	0.787245068082929	0.215569209713489	no	1028	0.227258180106044	698	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|CARBOHYDRATE METABOLISM	NUCLEUS	RSC COMPLEX	Subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; functions interdependently in transcriptional activation with Snf2p and Snf5p; relocates to the cytosol under hypoxic conditions	sucrose catabolic process|nucleotide-excision repair|chromatin remodeling|positive regulation of transcription from RNA polymerase II promoter	molecular_function	SWI/SNF complex|nucleus
YHR103W	YHR103W	SBE22	hom	Verified	0.786545535943107	0.215773976374271	no	1029	0.219384719157708	730	NA	FT	PROTEIN LOCALIZATION|CELL WALL ORG/BIOGENESIS	GOLGI APPARATUS		Protein involved in the transport of cell wall components from the Golgi to the cell surface; similar in structure and functionally redundant with Sbe2p; involved in bud growth	fungal-type cell wall organization	molecular_function	cytoplasm
YPL273W	YPL273W	SAM4	hom	Verified	0.786283216197986	0.215850791520802	no	1030	0.201901324271062	732	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM	NUCLEUS		S-adenosylmethionine-homocysteine methyltransferase, functions along with Mht1p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio	homocysteine metabolic process|L-methionine biosynthetic process from S-adenosylmethionine|S-adenosylhomocysteine metabolic process	homocysteine S-methyltransferase activity	nucleus|cytoplasm
YER014C-A	YER014C-A	BUD25	hom	Verified	0.784891657452195	0.216258546895647	no	1031	0.20174282294922	654	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CELL DIVISION			Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern	cellular bud site selection	molecular_function	cellular_component
YKR047W_d	YKR047W	YKR047W	hom	Dubious	0.784374924068999	0.216410073892134	no	1032	0.240388723994831	804	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NAP1	Unknown	Unknown	Unknown
YER077C_p	YER077C	YER077C	hom	Uncharacterized	0.784327485243448	0.216423987941265	no	1033	0.256157140549031	873	NA	FT		MITOCHONDRION		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; null mutation results in a decrease in plasma membrane electron transport	biological_process	molecular_function	mitochondrion
YJL172W	YJL172W	CPS1	hom	Verified	0.784314610206796	0.216427764344408	no	1034	0.236812582656293	760	NA	FT	PROTEOLYSIS			Vacuolar carboxypeptidase yscS; expression is induced under low-nitrogen conditions	nitrogen compound metabolic process|proteolysis involved in cellular protein catabolic process	carboxypeptidase activity	fungal-type vacuole lumen
YER123W	YER123W	YCK3	hom	Verified	0.784125193666591	0.216483326901753	no	1035	0.255961121496338	901	NA	FT	VESICLE-MEDIATED TRANSPORT|PROTEIN PHOSPHORYLATION	ENDOMEMBRANE SYSTEM|NUCLEUS|PLASMA MEMBRANE		Palmitoylated, vacuolar membrane-localized casein kinase I isoform; negatively regulates vacuole fusion during hypertonic stress via phosphorylation of Vps41p; shares essential functions with Hrr25p; regulates vesicle fusion in AP-3 pathway	vesicle-mediated transport|protein phosphorylation	protein serine/threonine kinase activity|protein kinase activity	fungal-type vacuole membrane|plasma membrane|nucleus|fungal-type vacuole
YAL018C_p	YAL018C	YAL018C	hom	Uncharacterized	0.782498348988414	0.216960877632237	no	1036	0.224907083475548	727	NA					Putative protein of unknown function	biological_process	molecular_function	integral to membrane
YDR097C	YDR097C	MSH6	hom	Verified	0.780638096286346	0.21750768937835	no	1037	0.188950486459818	636	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Protein required for mismatch repair in mitosis and meiosis, forms a complex with Msh2p to repair both single-base & insertion-deletion mispairs; also involved in interstrand cross-link repair; potentially phosphorylated by Cdc28p	mismatch repair|meiotic mismatch repair	guanine/thymine mispair binding|four-way junction DNA binding|ATPase activity|single base insertion or deletion binding|ATP binding	MutSalpha complex|nucleus
YLR386W	YLR386W	VAC14	hom	Verified	0.77970967927864	0.217780890108084	no	1038	0.255708404340025	900	NA	FT	PROTEIN LOCALIZATION|LIPID METABOLISM			Protein involved in regulated synthesis of PtdIns(3,5)P(2), in control of trafficking of some proteins to the vacuole lumen via the MVB, and in maintenance of vacuole size and acidity; interacts with Fig4p; activator of Fab1p	phosphatidylinositol biosynthetic process|positive regulation of kinase activity	protein binding, bridging	fungal-type vacuole membrane|PAS complex|extrinsic to vacuolar membrane
YML113W	YML113W	DAT1	hom	Verified	0.779140507622339	0.21794847529367	no	1039	0.202476890759915	708	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		DNA binding protein that recognizes oligo(dA).oligo(dT) tracts; Arg side chain in its N-terminal pentad Gly-Arg-Lys-Pro-Gly repeat is required for DNA-binding; not essential for viability	negative regulation of transcription from RNA polymerase II promoter	AT DNA binding	nucleus
YLR241W_p	YLR241W	YLR241W	hom	Uncharacterized	0.779067533442494	0.21796996696773	no	1040	0.198333326534936	639	NA					Putative protein of unknown function, may be involved in detoxification	biological_process	molecular_function	integral to membrane
YPL148C	YPL148C	PPT2	hom	Verified	0.775106816769844	0.219138271938977	no	1041	0.27153772475021	944	NA	FF|FT	KETONE METABOLISM|LIPID METABOLISM	MITOCHONDRION		Phosphopantetheine:protein transferase (PPTase), activates mitochondrial acyl carrier protein (Acp1p) by phosphopantetheinylation	protein-cofactor linkage	holo-[acyl-carrier-protein] synthase activity	mitochondrion
YBR085C-A	YBR085C-A	YBR085C-A	hom	Verified	0.774453244145439	0.219331403780083	no	1042	0.195551702756566	699	NA	FT		NUCLEUS		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	nucleus|cytoplasm
YFL036W	YFL036W	RPO41	hom	Verified	0.773243396583679	0.219689173836491	no	1043	0.224858735041625	747	NA	FT	MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial RNA polymerase; single subunit enzyme similar to those of T3 and T7 bacteriophages; requires a specificity subunit encoded by MTF1 for promoter recognition; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation	transcription from mitochondrial promoter|mitochondrial genome maintenance	DNA-directed RNA polymerase activity	mitochondrial nucleoid|mitochondrion|mitochondrial DNA-directed RNA polymerase complex|mitochondrial matrix
YDR488C	YDR488C	PAC11	hom	Verified	0.773183188841514	0.219706986916513	no	1044	0.181573782545263	619	NA	FT		CYTOSKELETON		Dynein intermediate chain, acts in the cytoplasmic dynein pathway, forms cortical cytoplasmic microtubule capture site with Num1p; null mutant is defective in nuclear migration, essential in the absence of CIN8	nuclear migration along microtubule|microtubule-based process	plus-end-directed microtubule motor activity|microtubule motor activity	cytoplasmic dynein complex|cytoplasmic microtubule
YNR029C_p	YNR029C	YNR029C	hom	Uncharacterized	0.772646035590772	0.219865945931242	no	1045	0.199421428518576	712	NA					Putative protein of unknown function, deletion confers reduced fitness in saline	biological_process	molecular_function	cytoplasm
YER177W	YER177W	BMH1	hom	Verified	0.771135354352522	0.220313353419011	no	1046	0.222444935700724	796	NA	FT	CELL CYCLE|SIGNALING|RESPONSE TO DNA DAMAGE|CELL WALL ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS		14-3-3 protein, major isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress	glycogen metabolic process|pseudohyphal growth|signal transduction involved in filamentous growth|ascospore formation|fungal-type cell wall chitin biosynthetic process|Ras protein signal transduction|DNA damage checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	DNA replication origin binding|phosphoserine binding	plasma membrane|nucleus
YLR405W	YLR405W	DUS4	hom	Verified	0.770088978548658	0.22062355667588	no	1047	0.208834141239483	674	NA	FT	RNA PROCESSING|OXIDATION-REDUCTION PROCESS			Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus3p	tRNA modification	tRNA dihydrouridine synthase activity	cellular_component
YPR053C_d	YPR053C	YPR053C	hom	Dubious	0.76945064482987	0.220812916662619	no	1048	0.208573519933266	729	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene NHP6A/YPR052C	Unknown	Unknown	Unknown
YML086C	YML086C	ALO1	hom	Verified	0.769182168897605	0.220892587122111	no	1049	0.195827356635931	645	NA	FT	OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS	MITOCHONDRION		D-Arabinono-1,4-lactone oxidase, catalyzes the final step in biosynthesis of dehydro-D-arabinono-1,4-lactone, which is protective against oxidative stress	cellular response to oxidative stress|dehydro-D-arabinono-1,4-lactone biosynthetic process	D-arabinono-1,4-lactone oxidase activity	mitochondrial outer membrane|mitochondrion|integral to mitochondrial outer membrane
YEL017C-A	YEL017C-A	PMP2	hom	Verified	0.768950571379037	0.220961327100456	no	1050	0.236361543113996	825	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Proteolipid associated with plasma membrane H(+)-ATPase (Pma1p); regulates plasma membrane H(+)-ATPase activity; protein abundance increases in response to DNA replication stress; PMP2 has a paralog, PMP1, that arose from the whole genome duplication	cation transport	molecular_function	membrane
YNL066W	YNL066W	SUN4	hom	Verified	0.766861714322383	0.221581869418738	no	1051	0.236308590191939	771	NA	FT	CELL CYCLE|CELL WALL ORG/BIOGENESIS|CELL DIVISION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Cell wall protein related to glucanases, possibly involved in cell wall septation; member of the SUN family	mitochondrion organization	glucosidase activity	fungal-type cell wall|mitochondrial matrix
YPL261C_d	YPL261C	YPL261C	hom	Dubious	0.766693780642091	0.221631801142655	no	1052	0.218616057241321	764	NA					Dubious open reading frame unlikely to encode a protein; partially overlaps the uncharacterized ORF YPL260W	Unknown	Unknown	Unknown
YER068C-A_d	YER068C-A	YER068C-A	hom	Dubious	0.766333604962919	0.221738913864384	no	1053	0.216255823907117	727	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YKL181W	YKL181W	PRS1	hom	Verified	0.765721675857286	0.221920963381611	no	1054	0.221065813642644	778	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM			5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes	fungal-type cell wall organization|5-phosphoribose 1-diphosphate biosynthetic process	ribose phosphate diphosphokinase activity	cytoplasm
YNL292W	YNL292W	PUS4	hom	Verified	0.765198696810736	0.222076617789068	no	1055	0.226176825125695	791	NA	FT	RNA PROCESSING	NUCLEUS|MITOCHONDRION		Pseudouridine synthase, catalyzes only the formation of pseudouridine-55 (Psi55), a highly conserved tRNA modification, in mitochondrial and cytoplasmic tRNAs; PUS4 overexpression leads to translational derepression of GCN4 (Gcd- phenotype)	tRNA modification	pseudouridine synthase activity	mitochondrion|nucleus
YPL239W	YPL239W	YAR1	hom	Verified	0.764844456525694	0.22218208582314	no	1056	0.218509650300516	726	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RESPONSE TO OXIDATIVE STRESS			Ankyrin-repeat containing, nucleocytoplasmic shuttling chaperone; prevents aggregation of Rps3p in the cytoplasm, associates with free Rps3p in the cytoplasm and delivers it to the 90S in the nucleus; required for 40S ribosomal subunit export, biogenesis and adaptation to osmotic and oxidative stress; expression repressed by heat shock	ribosomal small subunit biogenesis|cellular response to oxidative stress|response to osmotic stress	molecular_function	cytoplasm
YKR013W	YKR013W	PRY2	hom	Verified	0.763767798818606	0.222502814757209	no	1057	0.250193610091364	877	NA					Sterol binding protein involved in the export of acetylated sterols; secreted glycoprotein and member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis related 1 proteins); sterol export function is redundant with that of PRY1; may be involved in detoxification of hydrophobic compounds; PRY2 has a paralog, PRY1, that arose from the whole genome duplication	biological_process	molecular_function	extracellular region|fungal-type vacuole
YOL042W	YOL042W	NGL1	hom	Verified	0.762867472849386	0.222771218253621	no	1058	0.213921557972734	739	NA	FT		MITOCHONDRION		Putative endonuclease, has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	endonuclease activity	mitochondrion
YGR262C	YGR262C	BUD32	hom	Verified	0.762419031352938	0.222904975602425	no	1059	0.263939070174103	853	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|LIPID METABOLISM|CELL DIVISION|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION	NUCLEUS|CHROMOSOME		Protein kinase, component of the EKC/KEOPS complex with Kae1p, Cgi121p, Pcc1p, and Gon7p; EKC/KEOPS complex is required for t6A tRNA modification and may have roles in telomere maintenance and transcription	threonylcarbamoyladenosine metabolic process|protein phosphorylation|telomere maintenance|cellular bud site selection|positive regulation of transcription from RNA polymerase II promoter	protein serine/threonine kinase activity	EKC/KEOPS complex|nucleus|cytoplasm
YDR306C_p	YDR306C	YDR306C	hom	Uncharacterized	0.76223879706863	0.222958747251724	no	1060	0.240156041146219	797	NA	FT	PROTEOLYSIS			F-box protein of unknown function; interacts with Sgt1p via a Leucine-Rich Repeat (LRR) domain	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	ubiquitin-protein ligase activity|protein binding, bridging	SCF ubiquitin ligase complex
YOR186W_p	YOR186W	YOR186W	hom	Uncharacterized	0.762078416308224	0.223006601951696	no	1061	0.210831294087911	739	NA					Putative protein of unknown function; proper regulation of expression during heat stress is sphingolipid-dependent; YOR186W has a paralog, YLR297W, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YML034C-A_d	YML034C-A	YML034C-A	hom	Dubious	0.76155734416603	0.223162120766775	no	1062	0.243062461268881	836	NA					Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YPR191W	YPR191W	QCR2	hom	Verified	0.760308651767766	0.223535055761333	no	1063	0.199884290726263	692	NA	FT	OXIDATION-REDUCTION PROCESS|PROTEOLYSIS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Subunit 2 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; phosphorylated; transcription is regulated by Hap1p, Hap2p/Hap3p, and heme	mitochondrial electron transport, ubiquinol to cytochrome c|aerobic respiration	ubiquinol-cytochrome-c reductase activity	mitochondrion|integral to membrane|mitochondrial crista|mitochondrial respiratory chain complex III
YLR329W	YLR329W	REC102	hom	Verified	0.7590834381115	0.223901322887845	no	1064	0.240613164354855	814	NA	FT	CELL CYCLE	NUCLEUS|CHROMOSOME		Protein involved in early stages of meiotic recombination; required for chromosome synapsis; forms a complex with Rec104p and Spo11p necessary during the initiation of recombination	meiotic DNA double-strand break formation|reciprocal meiotic recombination	molecular_function	condensed nuclear chromosome|nucleus
YJL102W	YJL102W	MEF2	hom	Verified	0.757650469117183	0.224330129059698	no	1065	0.242641206286695	823	NA	FT	TRANSLATION|NUCLEOTIDE METABOLISM	MITOCHONDRION		Mitochondrial elongation factor involved in translational elongation	translational elongation	translation elongation factor activity	mitochondrion
YML097C	YML097C	VPS9	hom	Verified	0.756739168851116	0.22460307176393	no	1066	0.220191266879881	762	NA	FF|FT	PROTEIN LOCALIZATION|VACUOLAR TRANSPORT			A guanine nucleotide exchange factor involved in vesicle-mediated vacuolar protein transport; specifically stimulates the intrinsic guanine nucleotide exchange activity of Vps21p/Rab5: similar to mammalian ras inhibitors; binds ubiquitin	vacuole inheritance|protein targeting to vacuole	ubiquitin binding|guanyl-nucleotide exchange factor activity	cytosol
YGR092W	YGR092W	DBF2	hom	Verified	0.755722776953272	0.224907712475133	no	1067	0.299212347298908	1032	NA	FF|FT	CELL CYCLE|ION HOMEOSTASIS|PROTEIN PHOSPHORYLATION|ION HOMEOSTASIS	SITE OF POLARIZED GROWTH|CYTOSKELETON		Ser/Thr kinase involved in transcription and stress response; functions as part of a network of genes in exit from mitosis; localization is cell cycle regulated; activated by Cdc15p during the exit from mitosis; also plays a role in regulating the stability of SWI5 and CLB2 mRNAs; phosphorylates Chs2p to regulate primary septum formation and Hof1p to regulate cytokinesis	nuclear division|protein phosphorylation|vacuolar acidification	protein serine/threonine kinase activity|protein kinase activity	spindle pole body|cellular bud neck
YER057C	YER057C	HMF1	hom	Verified	0.755563838150168	0.224955371990554	no	1068	0.193167119027459	635	NA	FT		NUCLEUS		Member of the p14.5 protein family with similarity to Mmf1p, functionally complements Mmf1p function when targeted to mitochondria; heat shock inducible; high-dosage growth inhibitor; forms a homotrimer in vitro	biological_process	molecular_function	cytosol|nucleus|cytoplasm
YMR267W	YMR267W	PPA2	hom	Verified	0.754410237115484	0.225301463214353	no	1069	0.250721112853545	869	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Mitochondrial inorganic pyrophosphatase, required for mitochondrial function and possibly involved in energy generation from inorganic pyrophosphate	aerobic respiration	inorganic diphosphatase activity	mitochondrion
YNL125C	YNL125C	ESBP6	hom	Verified	0.754389007914115	0.225307834999852	no	1070	0.220024313758016	742	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION		Protein with similarity to monocarboxylate permeases, appears not to be involved in transport of monocarboxylates such as lactate, pyruvate or acetate across the plasma membrane	transport	monocarboxylic acid transmembrane transporter activity|transporter activity	mitochondrion|integral to membrane|endoplasmic reticulum|membrane
YLR328W	YLR328W	NMA1	hom	Verified	0.753482372631485	0.225580049999721	no	1071	0.258035415410677	840	NA	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM	NUCLEUS		Nicotinic acid mononucleotide adenylyltransferase; catalyzes the transfer of the adenylyl moiety of ATP to nicotinamide mononucleotide to form NAD; involved in pathways of NAD biosynthesis, including the de novo, NAD(+) salvage, and nicotinamide riboside salvage pathways; NMA1 has a paralog, NMA2, that arose from the whole genome duplication	NAD biosynthetic process	nicotinamide-nucleotide adenylyltransferase activity	nucleus|cytoplasm
YNL080C	YNL080C	EOS1	hom	Verified	0.753275113137143	0.225642305276852	no	1072	0.243807538838793	808	NA	FT	CARBOHYDRATE METABOLISM|RESPONSE TO OXIDATIVE STRESS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein involved in N-glycosylation; deletion mutation confers sensitivity to exidative stress and shows synthetic lethality with mutations in the spindle checkpoint genes BUB3 and MAD1; YNL080C is not an essential gene	cellular response to oxidative stress|protein N-linked glycosylation	molecular_function	integral to membrane|endoplasmic reticulum membrane
YCR024C-A	YCR024C-A	PMP1	hom	Verified	0.752873871891772	0.2257628551707	no	1073	0.251917644792639	865	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Regulatory subunit for the plasma membrane H(+)-ATPase Pma1p; small single-membrane span proteolipid; forms unique helix and positively charged cytoplasmic domain that is able to specifically segregate phosphatidylserines; PMP1 has a paralog, PMP2, that arose from the whole genome duplication	cation transport	enzyme regulator activity	plasma membrane|membrane
YLL059C_d	YLL059C	YLL059C	hom	Dubious	0.752007907590138	0.226023151703669	no	1074	0.24795872868162	859	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YIR017C	YIR017C	MET28	hom	Verified	0.751760642569948	0.226097507170742	no	1075	0.254978560363938	868	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Basic leucine zipper (bZIP) transcriptional activator in the Cbf1p-Met4p-Met28p complex, participates in the regulation of sulfur metabolism	regulation of transcription from RNA polymerase II promoter|regulation of sulfur amino acid metabolic process|Unknown	RNA polymerase II activating transcription factor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YFL030W	YFL030W	AGX1	hom	Verified	0.749129309162222	0.226889635575344	no	1076	0.216702418444013	711	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		Alanine:glyoxylate aminotransferase (AGT), catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast; has similarity to mammalian and plant alanine:glyoxylate aminotransferases	glycine biosynthetic process, by transamination of glyoxylate	alanine-glyoxylate transaminase activity	mitochondrion
YDR298C	YDR298C	ATP5	hom	Verified	0.748886847148611	0.226962704266128	no	1077	0.23961061620231	827	NA	FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS	MITOCHONDRION		Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase, which is an evolutionarily conserved enzyme complex required for ATP synthesis; homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein); phosphorylated	ATP synthesis coupled proton transport	hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism	mitochondrion|integral to membrane|mitochondrial proton-transporting ATP synthase, stator stalk|mitochondrial proton-transporting ATP synthase complex
YLR338W_d	YLR338W	OPI9	hom	Dubious	0.746937525692479	0.227550636502811	no	1078	0.281268500291477	967	NA	FF				Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF VRP1/YLR337C	Unknown	Unknown	Unknown
YPL253C	YPL253C	VIK1	hom	Verified	0.745974249540455	0.227841485256858	no	1079	0.231263955959527	806	NA	FT	CELL CYCLE|CHROMOSOME SEGREGATION	NUCLEUS|CYTOSKELETON		Protein that forms a complex with Kar3p at the spindle pole body, possible regulator of Kar3p function in microtubule-mediated processes; required for sister chromatid cohesion; has similarity to Cik1p	microtubule-based process|mitotic sister chromatid cohesion	microtubule motor activity	kinesin complex|spindle pole body
YHR014W	YHR014W	SPO13	hom	Verified	0.74297424297952	0.228748637330399	no	1080	0.19520710877275	658	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME		Meiosis-specific protein, involved in maintaining sister chromatid cohesion during meiosis I as well as promoting proper attachment of kinetochores to the spindle during meiosis I and meiosis II	protein localization to chromosome, centromeric region|meiotic sister chromatid cohesion|positive regulation of sister chromatid cohesion	molecular_function	nucleus|condensed nuclear chromosome, centromeric region
YLR412C-A_p	YLR412C-A	YLR412C-A	hom	Uncharacterized	0.742792707967154	0.228803595485417	no	1081	0.229218416200255	787	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YKR014C	YKR014C	YPT52	hom	Verified	0.742648587253287	0.228847232062622	no	1082	0.235591696758963	821	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING|VACUOLAR TRANSPORT	ENDOPLASMIC RETICULUM|PLASMA MEMBRANE		Rab family GTPase, similar to Ypt51p and Ypt53p and to mammalian rab5; required for vacuolar protein sorting and endocytosis; protein abundance increases in response to DNA replication stress	endocytosis|protein targeting to vacuole	GTPase activity	late endosome
YMR167W	YMR167W	MLH1	hom	Verified	0.742319583778838	0.228946864567694	no	1083	0.202555306748352	688	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS|MITOCHONDRION|CHROMOSOME		Protein required for mismatch repair in mitosis and meiosis as well as crossing over during meiosis; forms a complex with Pms1p and Msh2p-Msh3p during mismatch repair; human homolog is associated with hereditary non-polyposis colon cancer	mismatch repair|meiotic mismatch repair|reciprocal meiotic recombination|meiotic heteroduplex formation	double-stranded DNA binding|DNA insertion or deletion binding|loop DNA binding|single-stranded DNA binding|dinucleotide insertion or deletion binding|ATPase activity|ATP binding	mitochondrion|nucleus|MutLalpha complex|MutLbeta complex|cytoplasm
YLR375W	YLR375W	STP3	hom	Verified	0.741375532460336	0.229232887811007	no	1084	0.244717574041374	826	NA	FT		NUCLEUS		Zinc-finger protein of unknown function, possibly involved in pre-tRNA splicing and in uptake of branched-chain amino acids	biological_process	sequence-specific DNA binding	nucleus
YML021C	YML021C	UNG1	hom	Verified	0.741202167401973	0.229285434727703	no	1085	0.229532815832823	807	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS|MITOCHONDRION		Uracil-DNA glycosylase, required for repair of uracil in DNA formed by spontaneous cytosine deamination, not required for strand-specific mismatch repair, cell-cycle regulated, expressed in late G1, localizes to mitochondria and nucleus	DNA repair	uracil DNA N-glycosylase activity	mitochondrion|nucleus
YGL042C_d	YGL042C	YGL042C	hom	Dubious	0.74033444458211	0.229548542819394	no	1086	0.230064569649231	792	NA					Dubious open reading frame, not conserved in closely related Saccharomyces species; deletion mutation blocks replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene DST1	Unknown	Unknown	Unknown
YGR106C	YGR106C	VOA1	hom	Verified	0.740166392957574	0.22959951843261	no	1087	0.29405500224603	1008	NA	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Endoplasmic reticulum protein that functions, together with other assembly factors, in assembly of the V0 sector of the vacuolar ATPase (V-ATPase); null mutation enhances the V-ATPase deficiency of a vma21 mutant impaired in ER retrieval	protein complex assembly	molecular_function	fungal-type vacuole membrane|endoplasmic reticulum membrane
YOL032W	YOL032W	OPI10	hom	Verified	0.739759950018394	0.229722832224985	no	1088	0.198493255105027	675	NA	FT	LIPID METABOLISM|CARBOHYDRATE METABOLISM	NUCLEUS		Protein with a possible role in phospholipid biosynthesis; null mutant displays an inositol-excreting phenotype that is suppressed by exogenous choline; protein abundance increases in response to DNA replication stress	inositol metabolic process	molecular_function	nucleus|cytoplasm
YKL062W	YKL062W	MSN4	hom	Verified	0.739473835507725	0.229809660907331	no	1089	0.226837164100361	753	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO NUTRIENT LEVELS|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		Transcriptional activator; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression; MSN4 has a paralog, MSN2, that arose from the whole genome duplication	positive regulation of transcription from RNA polymerase II promoter in response to heat stress|positive regulation of transcription from RNA polymerase II promoter in response to a hypotonic environment|positive regulation of transcription from RNA polymerase II promoter in response to alkalinity|positive regulation of transcription from RNA polymerase II promoter in response to amino acid starvation|positive regulation of transcription from RNA polymerase II promoter in response to zinc ion starvation|positive regulation of transcription from RNA polymerase II promoter in response to acidity|chromatin remodeling|regulation of replicative cell aging by regulation of transcription from RNA polymerase II promoter in response to caloric restriction|positive regulation of transcription from RNA polymerase II promoter in response to hydrogen peroxide|positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance|positive regulation of transcription from RNA polymerase II promoter in response to increased salt|cellular response to acidity|positive regulation of transcription from RNA polymerase II promoter in response to freezing|positive regulation of transcription from RNA polymerase II promoter in response to ethanol|replicative cell aging|age-dependent response to oxidative stress involved in chronological cell aging|positive regulation of transcription from RNA polymerase II promoter in response to hydrostatic pressure|positive regulation of transcription from RNA polymerase II promoter in response to nitrosative stress|positive regulation of transcription from RNA polymerase II promoter in response to cold|positive regulation of transcription from RNA polymerase II promoter in response to glucose starvation	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity|core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding	cytosol|nucleus
YKR077W	YKR077W	MSA2	hom	Verified	0.738303309704848	0.230165077858467	no	1090	0.227924727343061	789	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE	NUCLEUS		Putative transcriptional activator, that interacts with G1-specific transcription factor, MBF and G1-specific promoters; ortholog of Msa2p, an MBF and SBF activator that regulates G1-specific transcription and cell cycle initiation	regulation of transcription involved in G1 phase of mitotic cell cycle	molecular_function	nucleus|cytoplasm
YKL128C	YKL128C	PMU1	hom	Verified	0.737547657376034	0.230394686392803	no	1091	0.192135935514799	636	NA	FT		NUCLEUS		Putative phosphomutase, contains a region homologous to the active site of phosphomutases; overexpression suppresses the histidine auxotrophy of an ade3 ade16 ade17 triple mutant and the temperature sensitivity of a tps2 mutant	biological_process	molecular_function	nucleus|cytoplasm
YGR169C-A_p	YGR169C-A	YGR169C-A	hom	Uncharacterized	0.736686661889118	0.230656459954548	no	1092	0.227500480450788	801	NA					Putative protein of unknown function; YGR169C-A has a paralog, YJR005C-A, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YLR152C_p	YLR152C	YLR152C	hom	Uncharacterized	0.736286799408682	0.230778088999877	no	1093	0.225517852109938	801	NA					Putative protein of unknown function; YLR152C is not an essential gene	biological_process	molecular_function	integral to membrane
YDR126W	YDR126W	SWF1	hom	Verified	0.736186152340686	0.230808709184306	no	1094	0.24897774378312	840	NA	FF|FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|CYTOSKELETON		Palmitoyltransferase that acts on transmembrane proteins, including the SNAREs Snc1p, Syn8p, Tlg1p and likely all SNAREs; contains an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; may have a role in vacuole fusion	ascospore wall assembly|cortical actin cytoskeleton organization|establishment of cell polarity|vacuole fusion, non-autophagic|regulation of exocytosis|protein palmitoylation	palmitoyltransferase activity	integral to membrane|actin filament bundle|nuclear outer membrane-endoplasmic reticulum membrane network|actin cortical patch
YGR070W	YGR070W	ROM1	hom	Verified	0.734196556219342	0.231414476030828	no	1095	0.24335380402904	869	NA	FT	SIGNALING|NUCLEOTIDE METABOLISM			GDP/GTP exchange protein (GEP) for Rho1p; mutations are synthetically lethal with mutations in rom2, which also encodes a GEP	small GTPase mediated signal transduction|activation of Rho GTPase activity	Rho guanyl-nucleotide exchange factor activity	intracellular
YCR098C	YCR098C	GIT1	hom	Verified	0.733299107377804	0.23168800967525	no	1096	0.238034284962505	851	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Plasma membrane permease, mediates uptake of glycerophosphoinositol and glycerophosphocholine as sources of the nutrients inositol and phosphate; expression and transport rate are regulated by phosphate and inositol availability	transmembrane transport|glycerophosphodiester transport	glycerophosphodiester transmembrane transporter activity	integral to membrane|plasma membrane
YOL080C	YOL080C	REX4	hom	Verified	0.732636100639988	0.231890203316205	no	1097	0.211271810817599	691	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Putative RNA exonuclease possibly involved in pre-rRNA processing and ribosome assembly	ribosomal large subunit assembly|rRNA processing	3'-5' exonuclease activity	nucleolus|nucleus
YOR267C	YOR267C	HRK1	hom	Verified	0.732461207427928	0.231943555946108	no	1098	0.191211307088943	623	NA	FT	ION HOMEOSTASIS|PROTEIN PHOSPHORYLATION|ION HOMEOSTASIS			Protein kinase; implicated in activation of the plasma membrane H(+)-ATPase Pma1p in response to glucose metabolism; plays a role in ion homeostasis; protein abundance increases in response to DNA replication stress	protein phosphorylation|cellular ion homeostasis	protein serine/threonine kinase activity|protein kinase activity	cytoplasm
YOL050C_d	YOL050C	YOL050C	hom	Dubious	0.73168941821891	0.232179078290802	no	1099	0.249629231185104	847	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps verified gene GAL11; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)	Unknown	Unknown	Unknown
YJL062W	YJL062W	LAS21	hom	Verified	0.731563548139378	0.232217501937566	no	1100	0.237476802043366	852	NA	FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|PLASMA MEMBRANE		Integral plasma membrane protein involved in the synthesis of the glycosylphosphatidylinositol (GPI) core structure; mutations affect cell wall integrity	GPI anchor biosynthetic process	mannose-ethanolamine phosphotransferase activity|transferase activity	integral to endoplasmic reticulum membrane|integral to membrane|integral to plasma membrane
YLR327C	YLR327C	TMA10	hom	Verified	0.730883460894105	0.232425169520614	no	1101	0.233384382175037	808	NA	FT		NUCLEUS|MITOCHONDRION		Protein of unknown function that associates with ribosomes; putative homolog of the F1F0-ATPase synthase regulator Stf2p; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	ribosome|nucleus|cytoplasm
YDR431W_d	YDR431W	YDR431W	hom	Dubious	0.730541195950509	0.232529720661388	no	1102	0.201774623189637	712	NA					Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YNL276C_d	YNL276C	YNL276C	hom	Dubious	0.729985148725022	0.232699631282209	no	1103	0.233806366982878	792	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene MET2/YNL277W	Unknown	Unknown	Unknown
YOR314W_d	YOR314W	YOR314W	hom	Dubious	0.729792467597271	0.232758524696025	no	1104	0.225312475908292	784	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YOL121C	YOL121C	RPS19A	hom	Verified	0.726393376243311	0.23379882532342	no	1105	0.23790465353129	794	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; required for assembly and maturation of pre-40 S particles; homologous to mammalian ribosomal protein S19, no bacterial homolog; mutations in human RPS19 are associated with Diamond Blackfan anemia; RPS19A has a paralog, RPS19B, that arose from the whole genome duplication	cytoplasmic translation|ribosomal small subunit biogenesis|rRNA export from nucleus	structural constituent of ribosome	cytosolic small ribosomal subunit
YHL041W_d	YHL041W	YHL041W	hom	Dubious	0.726046732086192	0.233905061261426	no	1106	0.198915684525186	689	NA					Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data	Unknown	Unknown	Unknown
YDR004W	YDR004W	RAD57	hom	Verified	0.726016589275608	0.233914300383989	no	1107	0.248852792340496	882	NA	FF|FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS		Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad55p	DNA recombinase assembly|telomere maintenance via recombination|heteroduplex formation|meiotic DNA recombinase assembly|double-strand break repair via single-strand annealing	DNA-dependent ATPase activity|protein heterodimerization activity	nucleus|Rhp55-Rhp57 complex
YML062C	YML062C	MFT1	hom	Verified	0.725872750055863	0.233958391564803	no	1108	0.24644455041724	855	NA	FT	TRANSCRIPTION FROM RNA POL II|RNA LOCALIZATION	NUCLEUS		Subunit of the THO complex, which is a nuclear complex comprised of Hpr1p, Mft1p, Rlr1p, and Thp2p, that is involved in transcription elongation and mitotic recombination; involved in telomere maintenance	mRNA export from nucleus|DNA recombination|transcription elongation from RNA polymerase II promoter	protein complex scaffold|nucleic acid binding	THO complex part of transcription export complex|nucleoplasmic THO complex
YBL010C_p	YBL010C	YBL010C	hom	Uncharacterized	0.724777884808644	0.234294152568332	no	1109	0.231514957493625	809	NA	FT		NUCLEUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein colocalizes with clathrin-coated vesicles	biological_process	molecular_function	clathrin-coated vesicle
YDR156W	YDR156W	RPA14	hom	Verified	0.723174928587084	0.234786209949972	no	1110	0.19870373136069	680	NA	FT		NUCLEUS		RNA polymerase I subunit A14	transcription of nuclear large rRNA transcript from RNA polymerase I promoter|regulation of cell size	molecular_function	DNA-directed RNA polymerase I complex
YJL022W_d	YJL022W	YJL022W	hom	Dubious	0.721143152179939	0.23541072180429	no	1111	0.24447148632385	799	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PET130	Unknown	Unknown	Unknown
YBR268W	YBR268W	MRPL37	hom	Verified	0.719366836668337	0.235957462332571	no	1112	0.278333421457809	964	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YML110C	YML110C	COQ5	hom	Verified	0.71877528441031	0.236139694203542	no	1113	0.259718120444784	887	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase, involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes	ubiquinone biosynthetic process|aerobic respiration	2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity	mitochondrion|mitochondrial matrix
YNR032W	YNR032W	PPG1	hom	Verified	0.717243110299175	0.236612051559439	no	1114	0.235189433269124	774	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS		Putative serine/threonine protein phosphatase of the type 2A-like phosphatase family, required for glycogen accumulation; interacts with Tap42p, which binds to and regulates other protein phosphatases	glycogen metabolic process|protein dephosphorylation	protein serine/threonine phosphatase activity	nucleus|cytoplasm
YPL095C	YPL095C	EEB1	hom	Verified	0.717034254820927	0.236676480314592	no	1115	0.25276795410904	880	NA	FT	KETONE METABOLISM|LIPID METABOLISM			Acyl-coenzymeA:ethanol O-acyltransferase; responsible for the major part of medium-chain fatty acid ethyl ester biosynthesis during fermentation; possesses short-chain esterase activity; may be involved in lipid metabolism and detoxification; EEB1 has a paralog, EHT1, that arose from the whole genome duplication	medium-chain fatty acid catabolic process|medium-chain fatty acid biosynthetic process	short-chain carboxylesterase activity|alcohol O-octanoyltransferase activity	cellular_component
YPR087W_d	YPR087W	VPS69	hom	Dubious	0.71682671563086	0.236740512573079	no	1116	0.258771613318717	871	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 85% of ORF overlaps the verified gene SRP54; deletion causes a vacuolar protein sorting defect	Unknown	Unknown	Unknown
YGL178W	YGL178W	MPT5	hom	Verified	0.716221848450275	0.236927187143126	no	1117	0.213761415840325	718	NA	FT	TRANSLATION			mRNA-binding protein of the PUF family; binds to the 3' UTR of specific mRNAs, including those involved in mating type switching, cell wall integrity, chronological lifespan, chromatin modification, and spindle pole body architecture; recruits the CCR4-NOT deadenylase complex to mRNAs along with Dhh1p and Dcp1p to promote deadenylation, decapping, and decay; also interacts with the Caf20p translational initiation repressor, affecting its mRNA target specificity	negative regulation of translation|negative regulation of translational initiation|Unknown	mRNA binding|protein binding, bridging	cytoplasm
YJR096W	YJR096W	YJR096W	hom	Verified	0.715837706379313	0.237045783361838	no	1118	0.231263479889271	804	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		Putative xylose and arabinose reductase; member of the aldo-keto reductase (AKR) family; GFP-fusion protein is induced in response to the DNA-damaging agent MMS	cellular response to oxidative stress|D-xylose catabolic process|arabinose catabolic process	alditol:NADP+ 1-oxidoreductase activity|aldo-keto reductase (NADP) activity	nucleus|cytoplasm
YGR100W	YGR100W	MDR1	hom	Verified	0.715174226583577	0.23725069635513	no	1119	0.245945496433064	853	NA	FT	PROTEIN LOCALIZATION|SIGNALING|NUCLEOTIDE METABOLISM			Cytoplasmic GTPase-activating protein for Ypt/Rab transport GTPases Ypt6p, Ypt31p and Sec4p; involved in recycling of internalized proteins and regulation of Golgi secretory function	intracellular protein transport	Rab GTPase activator activity	cytoplasm
YOR165W	YOR165W	SEY1	hom	Verified	0.714153786205479	0.237566044951124	no	1120	0.243782772951889	846	NA	FT	MEMBRANE ORGANIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Dynamin-like GTPase that mediates homotypic ER fusion; has a role in ER morphology; interacts physically and genetically with Yop1p and Rtn1p; functional ortholog of the human atlastin ATL1, defects in which cause a form of the human disease hereditary spastic paraplegia; homolog of Arabidopsis RHD3	cellular membrane organization|endoplasmic reticulum organization|endoplasmic reticulum membrane fusion|endoplasmic reticulum inheritance	GTPase activity	integral to membrane|endoplasmic reticulum|cortical endoplasmic reticulum|cytoplasm
YGR057C	YGR057C	LST7	hom	Verified	0.714046813396542	0.23759911627397	no	1121	0.297043687726371	993	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM		Protein possibly involved in a post-Golgi secretory pathway; required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface	intracellular protein transport|vesicle-mediated transport|protein transport|Golgi to plasma membrane transport	protein transporter activity	vesicle coat
YLR069C	YLR069C	MEF1	hom	Verified	0.713741548534751	0.237693504733332	no	1122	0.243396142961096	841	NA	FT	TRANSLATION|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial elongation factor involved in translational elongation	mitochondrial translational elongation|mitochondrial translation	translation elongation factor activity	mitochondrion
YKL149C	YKL149C	DBR1	hom	Verified	0.713207722024086	0.237858614306475	no	1123	0.224574031106693	771	NA	FT	RNA PROCESSING	NUCLEUS		RNA lariat debranching enzyme, involved in intron turnover; required for efficient Ty1 transposition	snoRNA metabolic process|pseudohyphal growth|RNA catabolic process|transposition, RNA-mediated	RNA lariat debranching enzyme activity	nucleus
YOL056W	YOL056W	GPM3	hom	Verified	0.712929593224956	0.237944662912471	no	1124	0.235779456284741	834	NA	FT	CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY			Homolog of Gpm1p phosphoglycerate mutase, which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event	biological_process	phosphoglycerate mutase activity|molecular_function	cytosol
YDR436W	YDR436W	PPZ2	hom	Verified	0.712578583820624	0.238053283969607	no	1125	0.23175870129896	789	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Serine/threonine protein phosphatase Z, isoform of Ppz1p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance	cellular sodium ion homeostasis	protein serine/threonine phosphatase activity	cellular_component
YDR495C	YDR495C	VPS3	hom	Verified	0.711855377713995	0.238277168223621	no	1126	0.264907757871754	913	NA	FF|FT	PROTEIN LOCALIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS|VACUOLAR TRANSPORT			Component of CORVET tethering complex; cytoplasmic protein required for the sorting and processing of soluble vacuolar proteins, acidification of the vacuolar lumen, and assembly of the vacuolar H+-ATPase	vacuole inheritance|vacuolar acidification|protein targeting to vacuole	molecular_function	CORVET complex|cytoplasm
YMR282C	YMR282C	AEP2	hom	Verified	0.711572698844223	0.238364708986518	no	1127	0.271570262327056	911	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial protein, likely involved in translation of the mitochondrial OLI1 mRNA; exhibits genetic interaction with the OLI1 mRNA 5'-untranslated leader	mitochondrial translational initiation	molecular_function	mitochondrion
YPL240C	YPL240C	HSP82	hom	Verified	0.711525967198318	0.238379182666376	no	1128	0.254710486478025	909	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION			Hsp90 chaperone; redundant in function with Hsc82p; required for pheromone signaling, negative regulation of Hsf1p; docks with Tom70p for mitochondrial preprotein delivery; promotes telomerase DNA binding, nucleotide addition; protein abundance increases in response to DNA replication stress; contains two acid-rich unstructured regions that promote solubility of chaperone-substrate complexes; HSP82 has a paralog, HSC82, that arose from the whole genome duplication	proteasome assembly|positive regulation of telomere maintenance via telomerase|box C/D snoRNP assembly|response to stress|protein refolding|protein targeting to mitochondrion|response to osmotic stress|'de novo' protein folding	unfolded protein binding|ATPase activity, coupled	cytoplasm
YIL170W	YIL170W	HXT12	hom	pseudogene	0.711055886146865	0.238524802478793	no	1129	0.229681049120833	783	NA					Possible pseudogene in strain S288C; YIL170W/HXT12 and the adjacent ORF, YIL171W, together encode a non-functional member of the hexose transporter family	hexose transport|biological_process	hexose transmembrane transporter activity|molecular_function	integral to membrane
YML067C	YML067C	ERV41	hom	Verified	0.709997681663587	0.238852786914627	no	1130	0.240439015010398	810	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Protein localized to COPII-coated vesicles, forms a complex with Erv46p; involved in the membrane fusion stage of transport; has homology to human ERGIC2 (PTX1) protein	ER to Golgi vesicle-mediated transport	molecular_function	integral to endoplasmic reticulum membrane|integral to Golgi membrane|ER to Golgi transport vesicle
YNR013C	YNR013C	PHO91	hom	Verified	0.709887889814848	0.238886830389345	no	1131	0.254089537548302	859	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Low-affinity phosphate transporter of the vacuolar membrane; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth	phosphate ion transport|polyphosphate metabolic process	phosphate ion transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane|membrane
YBL054W	YBL054W	TOD6	hom	Verified	0.709301643825209	0.239068654277695	no	1132	0.231205409511063	786	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS|CHROMOSOME		PAC motif binding protein involved in rRNA and ribosome biogenesis; subunit of the RPD3L histone deacetylase complex; Myb-like HTH transcription factor; hypophosphorylated by rapamycin treatment in a Sch9p-dependent manner; TOD6 has a paralog, DOT6, that arose from the whole genome duplication	regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding	Rpd3L-Expanded complex|nucleus|Rpd3L complex|cytoplasm
YDR095C_d	YDR095C	YDR095C	hom	Dubious	0.708987238568682	0.239166198059869	no	1133	0.243745656664197	790	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YPR098C	YPR098C	YPR098C	hom	Verified	0.708930343969273	0.239183851851892	no	1134	0.259780139362393	888	NA	FT		MITOCHONDRION		Protein of unknown function, localized to the mitochondrial outer membrane	biological_process	molecular_function	mitochondrial outer membrane|mitochondrion
YMR258C	YMR258C	ROY1	hom	Verified	0.70883961367561	0.23921200597491	no	1135	0.245521192864521	865	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|NUCLEOTIDE METABOLISM|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM|NUCLEUS		GTPase inhibitor with similarity to F-box proteins; inhibits Ypt52p GTPase activity by preventing Ypt52p from binding GTP; involved in regulating intracellular trafficking; physically interacts with Skp1p	endocytosis|protein targeting to vacuole|negative regulation of GTPase activity	GTPase inhibitor activity	nucleus|cytoplasm
YGL017W	YGL017W	ATE1	hom	Verified	0.708451226457094	0.239332545188721	no	1136	0.217521124928798	716	NA	FT	PROTEOLYSIS			Arginyl-tRNA-protein transferase, catalyzes post-translational conjugation of arginine to the amino termini of acceptor proteins which are then subject to degradation via the N-end rule pathway	cellular protein modification process|protein arginylation	arginyltransferase activity	cytoplasm
YER039C-A_p	YER039C-A	YER039C-A	hom	Uncharacterized	0.708065552744665	0.239452275067813	no	1137	0.235590651140952	804	NA					Putative protein of unknown function; YER039C-A is not an essential gene	biological_process	molecular_function	integral to membrane
YJL093C	YJL093C	TOK1	hom	Verified	0.708046592212018	0.239458162084447	no	1138	0.241745673064062	830	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Outward-rectifier potassium channel of the plasma membrane with two pore domains in tandem, each of which forms a functional channel permeable to potassium; carboxy tail functions to prevent inner gate closures; target of K1 toxin	cellular potassium ion homeostasis	potassium channel activity	integral to membrane|plasma membrane
YMR293C	YMR293C	HER2	hom	Verified	0.707913103212891	0.239499611045033	no	1139	0.248384706730444	887	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION	MITOCHONDRION		Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; required for remodeling of ER caused by Hmg2p overexpression; similar to bacterial GatA glutamyl-tRNA amidotransferase	endoplasmic reticulum organization|glutaminyl-tRNAGln biosynthesis via transamidation	glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity	mitochondrion|glutamyl-tRNA(Gln) amidotransferase complex
YOL019W_p	YOL019W	YOL019W	hom	Uncharacterized	0.707901905294312	0.239503088229376	no	1140	0.24933164963509	852	NA	FT		PLASMA MEMBRANE		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole; YOL019W has a paralog, DCV1, that arose from the whole genome duplication	biological_process	molecular_function	integral to membrane|plasma membrane|fungal-type vacuole
YPL181W	YPL181W	CTI6	hom	Verified	0.707560539927422	0.239609102433201	no	1141	0.250809901029689	867	NA	FT	CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS|CHROMOSOME		Protein that relieves transcriptional repression by binding to the Cyc8p-Tup1p corepressor and recruiting the SAGA complex to the repressed promoter; contains a PHD finger domain	negative regulation of chromatin silencing at silent mating-type cassette|positive regulation of transcription, DNA-dependent|regulation of DNA-dependent DNA replication initiation|negative regulation of chromatin silencing at telomere|negative regulation of chromatin silencing at rDNA	methylated histone residue binding|transcription factor binding	Rpd3L-Expanded complex|nucleus|Rpd3L complex
YBL053W_d	YBL053W	YBL053W	hom	Dubious	0.706950059274544	0.239798756750428	no	1142	0.239237223998061	827	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YKR082W	YKR082W	NUP133	hom	Verified	0.706458191838485	0.239951621775428	no	1143	0.243030954555728	826	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport and NPC biogenesis and is involved in establishment of a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p; also plays roles in several processes that may require localization of genes or chromosomes at the nuclear periphery, including double-strand break repair, transcription and chromatin silencing; homologous to human NUP133	poly(A)+ mRNA export from nucleus|double-strand break repair|maintenance of chromatin silencing at telomere|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|tRNA export from nucleus|telomere tethering at nuclear periphery|nuclear pore distribution|mRNA export from nucleus in response to heat stress|positive regulation of transcription, DNA-dependent|negative regulation of transcription from RNA polymerase II promoter|protein import into nucleus|positive regulation of transcription from RNA polymerase II promoter|chromatin silencing at silent mating-type cassette	structural constituent of nuclear pore	integral to membrane|nuclear pore|nuclear pore outer ring
YGR196C	YGR196C	FYV8	hom	Verified	0.705542723457879	0.24023627706896	no	1144	0.240672791663426	821	NA					Protein of unknown function, required for survival upon exposure to K1 killer toxin	biological_process	molecular_function	cytoplasm
YPL236C	YPL236C	ENV7	hom	Verified	0.705478483060268	0.240256258854191	no	1145	0.213560759186926	767	NA	FT	PROTEIN PHOSPHORYLATION|VACUOLAR PROTEIN PROCESSING			Vacuolar membrane protein kinase; negatively regulates membrane fusion; associates with vacuolar membrane through palmitoylation of one or more cysteines in consensus sequence; vacuolar membrane association is essential to its kinase activity; mutant shows defect in CPY processing; ortholog of human serine/threonine kinase 16 (STK16)	vacuolar protein processing	protein serine/threonine kinase activity	fungal-type vacuole membrane
YMR280C	YMR280C	CAT8	hom	Verified	0.705289351669526	0.240315092870321	no	1146	0.202663239092482	725	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Zinc cluster transcriptional activator; necessary for derepression of a variety of genes under non-fermentative growth conditions, active after diauxic shift, binds carbon source responsive elements; relative distribution to the nucleus increases upon DNA replication stress	positive regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source|positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter|positive regulation of glyoxylate cycle by positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YFR032C-A	YFR032C-A	RPL29	hom	Verified	0.704742113102136	0.240485369221816	no	1147	0.241985204013911	814	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L29; not essential for translation, but required for proper joining of large and small ribosomal subunits and for normal translation rate; homologous to mammalian ribosomal protein L29, no bacterial homolog	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit|cytoplasm
YOR190W	YOR190W	SPR1	hom	Verified	0.704541949793903	0.240547667565807	no	1148	0.241772392704375	860	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM			Sporulation-specific exo-1,3-beta-glucanase; contributes to ascospore thermoresistance	ascospore formation	glucan exo-1,3-beta-glucosidase activity	fungal-type cell wall|ascospore wall
YLL060C	YLL060C	GTT2	hom	Verified	0.704492917459128	0.2405629296109	no	1149	0.233005568489985	813	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		Glutathione S-transferase capable of homodimerization; functional overlap with Gtt2p, Grx1p, and Grx2p; protein abundance increases in response to DNA replication stress	glutathione metabolic process	glutathione transferase activity	mitochondrion
YDR409W	YDR409W	SIZ1	hom	Verified	0.704411983288069	0.240588122731382	no	1150	0.239978234860862	796	NA	FT	CHROMOSOME SEGREGATION	NUCLEUS|SITE OF POLARIZED GROWTH|CHROMOSOME|CYTOSKELETON		SUMO/Smt3 ligase that promotes the attachment of sumo (Smt3p; small ubiquitin-related modifier) to proteins; binds Ubc9p and may bind septins; specifically required for sumoylation of septins in vivo; localized to the septin ring	protein sumoylation|chromosome segregation	SUMO ligase activity	nuclear chromatin|septin ring
YBR221W-A_p	YBR221W-A	YBR221W-A	hom	Uncharacterized	0.704403598216378	0.240590732911538	no	1151	0.233443265008289	768	NA					Putative protein of unknown function; identified by expression profiling and mass spectrometry	biological_process	molecular_function	cellular_component
YDR374C_p	YDR374C	YDR374C	hom	Uncharacterized	0.704232281152188	0.240644065395583	no	1152	0.2159491610831	735	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YKR070W_p	YKR070W	YKR070W	hom	Uncharacterized	0.704150177386587	0.240669627289008	no	1153	0.234771724370506	786	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YIR028W	YIR028W	DAL4	hom	Verified	0.703511854840832	0.24086841075502	no	1154	0.235133407904695	789	NA					Allantoin permease; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation	allantoin catabolic process|allantoin transport	allantoin uptake transmembrane transporter activity	integral to membrane|membrane
YKL206C	YKL206C	ADD66	hom	Verified	0.703405968386063	0.240901394062018	no	1155	0.235233402195213	806	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS			Protein involved in 20S proteasome assembly; forms a heterodimer with Pba1p that binds to proteasome precursors; similar to human PAC2 constituent of the PAC1-PAC2 complex involved in proteasome assembly	proteasome assembly	molecular_function	cytosol|cytoplasm
YDR151C	YDR151C	CTH1	hom	Verified	0.703302051872912	0.240933766126819	no	1156	0.247685561398452	847	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	NUCLEUS		Member of the CCCH zinc finger family; has similarity to mammalian Tis11 protein, which activates transcription and also has a role in mRNA degradation; may function with Tis11p in iron homeostasis	nuclear-transcribed mRNA catabolic process|cellular iron ion homeostasis	mRNA binding	nucleus
YDR475C	YDR475C	JIP4	hom	Verified	0.703004060335635	0.241026609549063	no	1157	0.233997803963444	790	NA					Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence	biological_process	molecular_function	cellular_component
YOR058C	YOR058C	ASE1	hom	Verified	0.702442285135025	0.24120169135065	no	1158	0.207852250835096	723	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION	NUCLEUS|CYTOSKELETON		Mitotic spindle midzone localized protein; microtubule-associated protein (MAP) family member; required for spindle elongation and stabilization; undergoes cell cycle-regulated degradation by anaphase promoting complex; potential Cdc28p substrate; relative distribution to microtubules decreases upon DNA replication stress	cytokinesis, completion of separation|mitotic anaphase B|microtubule bundle formation|spindle pole body separation|spindle midzone assembly|mitotic spindle stabilization|mitotic spindle elongation	microtubule binding	spindle midzone|nuclear microtubule|spindle
YLR203C	YLR203C	MSS51	hom	Verified	0.700377092417108	0.241845919174746	no	1159	0.22248752670372	722	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Specific translational activator for the mitochondrial COX1 mRNA; loosely associated with the matrix face of the mitochondrial inner membrane; influences both COX1 mRNA translation and Cox1p assembly into cytochrome c oxidase; binds to heme B, which may be a mechanism for sensing oxygen levels in order to regulate cytochrome c oxidase biogenesis	mitochondrial respiratory chain complex IV biogenesis|positive regulation of mitochondrial translation	translation regulator activity	extrinsic to mitochondrial inner membrane|mitochondrion
YJL155C	YJL155C	FBP26	hom	Verified	0.700275955510114	0.241877492352669	no	1160	0.236660179414396	841	NA	FT	CARBOHYDRATE METABOLISM			Fructose-2,6-bisphosphatase, required for glucose metabolism; protein abundance increases in response to DNA replication stress	glucose metabolic process	6-phosphofructo-2-kinase activity|fructose-2,6-bisphosphate 2-phosphatase activity	cytosol
YGR122C-A_d	YGR122C-A	YGR122C-A	hom	Dubious	0.699371230236424	0.242160031255842	no	1161	0.222951658774185	743	NA					Dubious open reading frame unlikely to encode a functional protein, similar to YLR334C and YOL106W	Unknown	Unknown	Unknown
YNL279W	YNL279W	PRM1	hom	Verified	0.699192317213586	0.24221592563081	no	1162	0.245935358223134	870	NA	FT	MEMBRANE ORGANIZATION	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Pheromone-regulated multispanning membrane protein involved in membrane fusion during mating; predicted to have 5 transmembrane segments and a coiled coil domain; localizes to the shmoo tip; regulated by Ste12p	plasma membrane fusion involved in cytogamy|response to pheromone	molecular_function	integral to membrane|mating projection tip
YCR061W_p	YCR061W	YCR061W	hom	Uncharacterized	0.698926022706618	0.242299131881135	no	1163	0.247193650960882	853	NA					Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; induced by treatment with 8-methoxypsoralen and UVA irradiation	regulation of cell size	molecular_function	integral to membrane|cytoplasm
YMR274C	YMR274C	RCE1	hom	Verified	0.698545144147579	0.242418167925083	no	1164	0.248675931455979	859	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Type II CAAX prenyl protease involved in the proteolysis and maturation of Ras and the a-factor mating pheromone	CAAX-box protein processing|peptide pheromone maturation|protein processing	metalloendopeptidase activity	integral to endoplasmic reticulum membrane|integral to membrane
YHR037W	YHR037W	PUT2	hom	Verified	0.697683628975121	0.242687534253828	no	1165	0.260052983919852	893	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS	MITOCHONDRION		Delta-1-pyrroline-5-carboxylate dehydrogenase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; deficiency of the human homolog causes HPII, an autosomal recessive inborn error of metabolism	glutamate biosynthetic process|proline catabolic process to glutamate	1-pyrroline-5-carboxylate dehydrogenase activity	mitochondrion|mitochondrial matrix
YFL042C_p	YFL042C	YFL042C	hom	Uncharacterized	0.697439358849435	0.242763938642055	no	1166	0.248886228152532	819	NA					Putative protein of unknown function; YFL042C is not an essential gene	biological_process	molecular_function	cellular_component
YEL036C	YEL036C	ANP1	hom	Verified	0.69650694954805	0.243055703308994	no	1167	0.284648401193183	961	NA	FT	CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Subunit of the alpha-1,6 mannosyltransferase complex; type II membrane protein; has a role in retention of glycosyltransferases in the Golgi; involved in osmotic sensitivity and resistance to aminonitrophenyl propanediol	protein N-linked glycosylation	alpha-1,6-mannosyltransferase activity|mannosyltransferase activity	alpha-1,6-mannosyltransferase complex|Golgi cis cisterna
YJL024C	YJL024C	APS3	hom	Verified	0.696466183517948	0.243068463928625	no	1168	0.259785483834963	914	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Small subunit of the clathrin-associated adaptor complex AP-3; involved in vacuolar protein sorting; related to the sigma subunit of the mammalian clathrin AP-3 complex; suppressor of loss of casein kinase 1 function; protein abundance increases in response to DNA replication stress	Golgi to vacuole transport|vesicle-mediated transport	molecular_function	AP-3 adaptor complex
YPR156C	YPR156C	TPO3	hom	Verified	0.696341483315375	0.243107499948016	no	1169	0.225451946487967	808	NA	FT		PLASMA MEMBRANE		Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; specific for spermine; localizes to the plasma membrane; TPO3 has a paralog, TPO2, that arose from the whole genome duplication	spermine transport	spermine transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane|plasma membrane
YIL166C_p	YIL166C	YIL166C	hom	Uncharacterized	0.696021859941971	0.243207569988851	no	1170	0.243807298785685	816	NA					Putative protein with similarity to the allantoate permease (Dal5p) subfamily of the major facilitator superfamily; mRNA expression is elevated by sulfur limitation; YIL166C is a non-essential gene	transport	transporter activity	integral to membrane|membrane
YPR096C	YPR096C	YPR096C	hom	Verified	0.695055863428504	0.243510146603699	no	1171	0.224555346491257	771	NA					Protein of unknown function that may interact with ribosomes, based on co-purification experiments	biological_process	molecular_function	ribosome
YLR211C_p	YLR211C	YLR211C	hom	Uncharacterized	0.694884572155274	0.243563820947808	no	1172	0.228765161811163	788	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR211C is not an essential gene; ORF contains an intron	biological_process	molecular_function	cytoplasm
YDR417C_d	YDR417C	YDR417C	hom	Dubious	0.69466991427979	0.243631093293473	no	1173	0.250460019929406	853	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RPL12B/YDR418W	Unknown	Unknown	Unknown
YGL240W	YGL240W	DOC1	hom	Verified	0.694538513392061	0.243672278405045	no	1174	0.253308169743587	890	NA	FT	CELL CYCLE|CHROMATIN ORGANIZATION|CELL DIVISION|PROTEOLYSIS	NUCLEUS|MITOCHONDRION	UBIQUITIN LIGASE COMPLEX	Processivity factor required for the ubiquitination activity of the anaphase promoting complex (APC), mediates the activity of the APC by contributing to substrate recognition; involved in cyclin proteolysis; contains a conserved DOC1 homology domain	activation of mitotic anaphase-promoting complex activity|chromatin assembly|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cyclin catabolic process	enzyme regulator activity|mitotic anaphase-promoting complex activity	mitochondrion|anaphase-promoting complex
YDR148C	YDR148C	KGD2	hom	Verified	0.69421632806586	0.243773277180296	no	1175	0.245228708418065	868	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Dihydrolipoyl transsuccinylase, component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes the oxidative decarboxylation of alpha-ketoglutarate to succinyl-CoA in the TCA cycle; phosphorylated	tricarboxylic acid cycle|mitochondrial genome maintenance|2-oxoglutarate metabolic process	dihydrolipoyllysine-residue succinyltransferase activity	mitochondrial nucleoid|mitochondrion|mitochondrial oxoglutarate dehydrogenase complex
YNR041C	YNR041C	COQ2	hom	Verified	0.693991725853706	0.243843698929791	no	1176	0.242989453237693	834	NA	FT	KETONE METABOLISM|LIPID METABOLISM|COFACTOR METABOLISM	MITOCHONDRION		Para hydroxybenzoate: polyprenyl transferase, catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis	ubiquinone biosynthetic process	4-hydroxybenzoate octaprenyltransferase activity	mitochondrion|integral to mitochondrial membrane|integral to membrane
YBR148W	YBR148W	YSW1	hom	Verified	0.693886105737366	0.243876818842897	no	1177	0.216428045627696	740	NA	FT	MEMBRANE ORGANIZATION			Protein required for normal prospore membrane formation; interacts with Gip1p, which is the meiosis-specific regulatory subunit of the Glc7p protein phosphatase; expressed specifically in spores and localizes to the prospore membrane	ascospore-type prospore membrane assembly	molecular_function	prospore membrane
YLR369W	YLR369W	SSQ1	hom	Verified	0.693243813224459	0.244078278492026	no	1178	0.240238685209025	806	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|COFACTOR METABOLISM	MITOCHONDRION		Mitochondrial hsp70-type molecular chaperone, required for assembly of iron/sulfur clusters into proteins at a step after cluster synthesis, and for maturation of Yfh1p, which is a homolog of human frataxin implicated in Friedreich's ataxia	iron-sulfur cluster assembly|intracellular sequestering of iron ion|protein maturation	unfolded protein binding	mitochondrion|mitochondrial matrix
YMR243C	YMR243C	ZRC1	hom	Verified	0.693103676224873	0.244122245391176	no	1179	0.245297313798829	843	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Vacuolar membrane zinc transporter; transports zinc from cytosol to vacuole for storage; also has role in resistance to zinc shock resulting from sudden influx of zinc into cytoplasm; human ortholog SLC30A10 functions as a Mn transporter and mutations in SLC30A10 cause neurotoxic accumulation of Mn in liver and brain; ZRC1 has a paralog, COT1, that arose from the whole genome duplication	cobalt ion transport|cellular zinc ion homeostasis|zinc ion transport|glutathione metabolic process	zinc ion transmembrane transporter activity|inorganic cation transmembrane transporter activity	integral to membrane|fungal-type vacuole
YCR064C_d	YCR064C	YCR064C	hom	Dubious	0.692717747398321	0.244243349648041	no	1180	0.276693064767762	961	NA	FF				Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene BUD31	Unknown	Unknown	Unknown
YOR274W	YOR274W	MOD5	hom	Verified	0.692570448870772	0.244289580384589	no	1181	0.250498126276967	866	NA	FT	RNA PROCESSING	NUCLEUS|MITOCHONDRION		Delta 2-isopentenyl pyrophosphate:tRNA isopentenyl transferase; required for biosynthesis of the modified base isopentenyladenosine in mitochondrial and cytoplasmic tRNAs; gene is nuclear and encodes two isozymic forms; converts to a prion form, and prion conversion contributes to azole antifungal resistance by upregulating ergosterol biosynthesis	tRNA modification	tRNA dimethylallyltransferase activity	cytosol|mitochondrion|nucleolus|nucleus
YJR094C	YJR094C	IME1	hom	Verified	0.692087505259449	0.244441188902077	no	1182	0.210533509495233	706	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE	NUCLEUS		Master regulator of meiosis that is active only during meiotic events, activates transcription of early meiotic genes through interaction with Ume6p, degraded by the 26S proteasome following phosphorylation by Ime2p	pseudohyphal growth|regulation of transcription from RNA polymerase II promoter|regulation of meiosis	protein binding transcription factor activity	nucleus
YKR090W	YKR090W	PXL1	hom	Verified	0.691907318643742	0.244497767134483	no	1183	0.247491758114108	854	NA	FT	SIGNALING	SITE OF POLARIZED GROWTH		Protein that localizes to sites of polarized growth; required for selection and/or maintenance of polarized growth sites, may modulate signaling by the GTPases Cdc42p and Rho1p; contains LIM domains and has similarity to metazoan paxillin; relocalizes from bud neck to cytoplasm upon DNA replication stress	maintenance of cell polarity|regulation of Rho protein signal transduction	Rho GDP-dissociation inhibitor activity	incipient cellular bud site|cellular bud|mating projection tip|cellular bud neck|cytoplasm|cellular bud tip
YOR089C	YOR089C	VPS21	hom	Verified	0.691364917400704	0.244668122600213	no	1184	0.300561728703196	1047	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING|VACUOLAR TRANSPORT	MITOCHONDRION		Rab family GTPase; required for endocytic transport and for sorting of vacuolar hydrolases; localized in endocytic intermediates; detected in mitochondria; geranylgeranylation required for membrane association; mammalian Rab5 homolog; protein abundance increases in response to DNA replication stress; VPS21 has a paralog, YPT53, that arose from the whole genome duplication	endocytosis|vacuole inheritance|protein targeting to vacuole	GTP binding|GTPase activity	mitochondrial outer membrane|late endosome|mitochondrion
YPL025C_d	YPL025C	YPL025C	hom	Dubious	0.691294220170574	0.2446903316438	no	1185	0.25284107992873	871	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YOR020W-A_p	YOR020W-A	YOR020W-A	hom	Uncharacterized	0.691076869628877	0.24475861760414	no	1186	0.23318726036964	791	NA	FT		MITOCHONDRION		Putative protein of unknown function, conserved in A. gossypii; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YLL052C	YLL052C	AQY2	hom	Verified	0.690591976889544	0.24491099542069	no	1187	0.250691724887998	865	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|PLASMA MEMBRANE		Water channel that mediates the transport of water across cell membranes, only expressed in proliferating cells, controlled by osmotic signals, may be involved in freeze tolerance; disrupted by a stop codon in many S. cerevisiae strains	water transport	water channel activity	plasma membrane|endoplasmic reticulum membrane
YGL138C_p	YGL138C	YGL138C	hom	Uncharacterized	0.690549212182894	0.244924436703062	no	1188	0.240075372959344	812	NA					Putative protein of unknown function; has no significant sequence similarity to any known protein	biological_process	molecular_function	cellular_component
YNL179C_d	YNL179C	YNL179C	hom	Dubious	0.690025246936841	0.245089155307269	no	1189	0.244697625674915	883	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; deletion in cyr1 mutant results in loss of stress resistance	Unknown	Unknown	Unknown
YGR244C	YGR244C	LSC2	hom	Verified	0.689110017686887	0.245377018191117	no	1190	0.247883893680044	856	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Beta subunit of succinyl-CoA ligase, which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate	tricarboxylic acid cycle|succinyl-CoA metabolic process	succinate-CoA ligase (ADP-forming) activity	mitochondrion
YOL110W	YOL110W	SHR5	hom	Verified	0.688187907812136	0.245667228869872	no	1191	0.245384525475273	842	NA	FT	PROTEIN LOCALIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Subunit of a palmitoyltransferase, composed of Shr5p and Erf2p, that adds a palmitoyl lipid moiety to heterolipidated substrates such as Ras1p and Ras2p through a thioester linkage; palmitoylation is required for Ras2p membrane localization	protein targeting to membrane|protein palmitoylation	palmitoyltransferase activity	endoplasmic reticulum palmitoyltransferase complex|extrinsic to endoplasmic reticulum membrane
YBR241C_p	YBR241C	YBR241C	hom	Uncharacterized	0.688011633307234	0.2457227277746	no	1192	0.190057835122951	632	NA					Putative transporter, member of the sugar porter family; green fluorescent protein (GFP)-fusion protein localizes to the vacuolar membrane; YBR241C is not an essential gene	transport|transmembrane transport	substrate-specific transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane|membrane
YOR179C	YOR179C	SYC1	hom	Verified	0.687661795916641	0.245832891782836	no	1193	0.243394334388809	845	NA	FT	TRANSCRIPTION FROM RNA POL II|RNA PROCESSING	NUCLEUS		Subunit of the APT subcomplex of cleavage and polyadenylation factor; may have a role in 3' end formation of both polyadenylated and non-polyadenylated RNAs; SYC1 has a paralog, YSH1, that arose from the whole genome duplication	termination of RNA polymerase II transcription, exosome-dependent|termination of RNA polymerase II transcription, poly(A)-coupled	RNA binding	mRNA cleavage and polyadenylation specificity factor complex|nucleus
YDR192C	YDR192C	NUP42	hom	Verified	0.6876212557997	0.24584565960431	no	1194	0.247562714015169	827	NA	FT	PROTEIN LOCALIZATION|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	FG-nucleoporin component of central core of the nuclear pore complex (NPC); also part of the NPC cytoplasmic filaments; contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier and is involved in gene tethering at the nuclear periphery; interacts with Gle1p	poly(A)+ mRNA export from nucleus|NLS-bearing substrate import into nucleus|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|mRNA export from nucleus in response to heat stress|transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery	nucleocytoplasmic transporter activity|structural constituent of nuclear pore	nuclear pore central transport channel|integral to membrane|nuclear pore cytoplasmic filaments|nuclear pore
YHR022C-A_p	YHR022C-A	YHR022C-A	hom	Uncharacterized	0.687614409229659	0.245847815917977	no	1195	0.239185817067116	830	NA					Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching	biological_process	molecular_function	cellular_component
YLR225C_p	YLR225C	YLR225C	hom	Uncharacterized	0.687503441717325	0.24588276633167	no	1196	0.252591988866334	878	NA	FT	RESPONSE TO OXIDATIVE STRESS			Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR225C is not an essential gene	biological_process	molecular_function	cytoplasm
YDL151C_d	YDL151C	BUD30	hom	Dubious	0.686877424764474	0.246079987062859	no	1197	0.26095295020839	893	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 96% of ORF overlaps the verified gene RPC53; diploid mutant displays a weak budding pattern phenotype in a systematic assay	Unknown	Unknown	Unknown
YHL004W	YHL004W	MRP4	hom	Verified	0.686791629830993	0.246107022556638	no	1198	0.252311253971826	887	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the small subunit	mitochondrial translation	structural constituent of ribosome|tRNA binding	mitochondrion|mitochondrial small ribosomal subunit
YKL156W	YKL156W	RPS27A	hom	Verified	0.686547641383026	0.246183916318341	no	1199	0.258227703996403	882	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S27, no bacterial homolog; RPS27A has a paralog, RPS27B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress	cytoplasmic translation|ribosomal small subunit assembly|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome	cytosolic small ribosomal subunit|cytoplasm
YHR150W	YHR150W	PEX28	hom	Verified	0.686523581783566	0.246191499478017	no	1200	0.218605819630828	764	NA	FT	PEROXISOME ORGANIZATION			Peroxisomal integral membrane peroxin, involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p	peroxisome organization	molecular_function	integral to membrane|peroxisomal membrane
YDR198C	YDR198C	RKM2	hom	Verified	0.685970183226217	0.246365955472397	no	1201	0.26542975801406	894	NA					Ribosomal protein lysine methyltransferase, responsible for trimethylation of the lysine residue at position 3 of Rpl12Ap and Rpl12Bp	peptidyl-lysine trimethylation|peptidyl-lysine monomethylation	protein-lysine N-methyltransferase activity	cellular_component
YMR306W	YMR306W	FKS3	hom	Verified	0.685760054241263	0.246432214885643	no	1202	0.258376109901036	898	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	MITOCHONDRION|PLASMA MEMBRANE		Protein involved in spore wall assembly, has similarity to 1,3-beta-D-glucan synthase catalytic subunits Fks1p and Gsc2p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	ascospore wall assembly	1,3-beta-D-glucan synthase activity	mitochondrion|integral to membrane
YNL315C	YNL315C	ATP11	hom	Verified	0.685663092206303	0.246462792885623	no	1203	0.250378544260879	870	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Molecular chaperone, required for the assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase	mitochondrion organization|mitochondrial proton-transporting ATP synthase complex assembly	unfolded protein binding	mitochondrion|mitochondrial matrix
YLR438W	YLR438W	CAR2	hom	Verified	0.684865775722034	0.246714312122433	no	1204	0.249168862866787	844	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		L-ornithine transaminase (OTAse); catalyzes the second step of arginine degradation, expression is dually-regulated by allophanate induction and a specific arginine induction process; not nitrogen catabolite repression sensitive; protein abundance increases in response to DNA replication stress	ornithine metabolic process|arginine catabolic process	ornithine-oxo-acid transaminase activity	cytosol|nucleus|cytoplasm
YLR344W	YLR344W	RPL26A	hom	Verified	0.684844535717134	0.246721014314196	no	1205	0.232490185824039	743	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L26A; binds to 5.8S rRNA; homologous to mammalian ribosomal protein L26 and bacterial L24; RPL26A has a paralog, RPL26B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome|RNA binding	cytosolic large ribosomal subunit
YOL013W-A_p	YOL013W-A	YOL013W-A	hom	Uncharacterized	0.684461168579244	0.246842000916435	no	1206	0.246043990243187	827	NA					Putative protein of unknown function; identified by SAGE	biological_process	molecular_function	integral to membrane
YGR045C_d	YGR045C	YGR045C	hom	Dubious	0.684164684839959	0.246935589812882	no	1207	0.230658238297404	784	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YCL024W	YCL024W	KCC4	hom	Verified	0.682499629064373	0.247461538622329	no	1208	0.246710379273617	865	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Protein kinase of the bud neck involved in the septin checkpoint; associates with septin proteins, negatively regulates Swe1p by phosphorylation, shows structural homology to bud neck kinases Gin4p and Hsl1p; KCC4 has a paralog, GIN4, that arose from the whole genome duplication	budding cell bud growth|protein phosphorylation|septin checkpoint|septin ring assembly	phosphatidic acid binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylserine binding|protein kinase activity	incipient cellular bud site|cellular bud neck septin collar|plasma membrane|cellular bud neck|septin ring
YDR092W	YDR092W	UBC13	hom	Verified	0.681791990099858	0.247685244922008	no	1209	0.237603042184875	822	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RESPONSE TO DNA DAMAGE	NUCLEUS		Ubiquitin-conjugating enzyme involved in the error-free DNA postreplication repair pathway; interacts with Mms2p to assemble ubiquitin chains at the Ub Lys-63 residue; DNA damage triggers redistribution from the cytoplasm to the nucleus	postreplication repair|protein monoubiquitination|protein polyubiquitination|free ubiquitin chain polymerization	ubiquitin-protein ligase activity	ubiquitin conjugating enzyme complex|nucleus|cytoplasm
YLL053C_p	YLL053C	YLL053C	hom	Uncharacterized	0.681769955160989	0.247692212572947	no	1210	0.228896669470985	778	NA					Putative protein; in the Sigma 1278B strain background YLL053C is contiguous with AQY2 which encodes an aquaporin	biological_process	molecular_function	integral to membrane
YIL046W-A_p	YIL046W-A	YIL046W-A	hom	Uncharacterized	0.68131023707826	0.247837603541509	no	1211	0.240569669278053	825	NA					Putative protein of unknown function; identified by expression profiling and mass spectrometry	biological_process	molecular_function	cellular_component
YDL189W	YDL189W	RBS1	hom	Verified	0.681142349708105	0.247890711148382	no	1212	0.234535019671452	774	NA	FT	CARBOHYDRATE METABOLISM			Protein of unknown function, identified as a high copy suppressor of psk1 psk2 mutations that confer temperature-sensitivity for galactose utilization; proposed to bind single-stranded nucleic acids via its R3H domain	galactose metabolic process	molecular_function	cytoplasm
YBR031W	YBR031W	RPL4A	hom	Verified	0.680853964838426	0.247981949758212	no	1213	0.239354631321234	856	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L4A; N-terminally acetylated; homologous to mammalian ribosomal protein L4 and bacterial L4; RPL4A has a paralog, RPL4B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YDR446W	YDR446W	ECM11	hom	Verified	0.680709919535171	0.24802752922366	no	1214	0.20638485975923	682	NA	FT	CELL CYCLE|CELL WALL ORG/BIOGENESIS	NUCLEUS		Non-essential protein apparently involved in meiosis, GFP fusion protein is present in discrete clusters in the nucleus throughout mitosis; may be involved in maintaining chromatin structure	fungal-type cell wall organization|reciprocal meiotic recombination	molecular_function	nucleus
YOR321W	YOR321W	PMT3	hom	Verified	0.680094979136485	0.248222161703642	no	1215	0.236367287122065	830	NA	FT	CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein O-mannosyltransferase; transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt5p, can instead interact with Pmt1p in some conditions; antifungal drug target; PMT3 has a paralog, PMT2, that arose from the whole genome duplication	protein O-linked glycosylation|protein O-linked mannosylation	dolichyl-phosphate-mannose-protein mannosyltransferase activity	integral to membrane|dolichyl-phosphate-mannose-protein mannosyltransferase complex
YML088W	YML088W	UFO1	hom	Verified	0.680013388028883	0.248247991917872	no	1216	0.237796824057319	794	NA	FT	RESPONSE TO DNA DAMAGE|PROTEOLYSIS	NUCLEUS	UBIQUITIN LIGASE COMPLEX	F-box receptor protein, subunit of the Skp1-Cdc53-F-box receptor (SCF) E3 ubiquitin ligase complex; binds to phosphorylated Ho endonuclease, allowing its ubiquitylation by SCF and subsequent degradation	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|cellular response to methylmercury|response to DNA damage stimulus	ubiquitin-protein ligase activity|protein binding, bridging	SCF ubiquitin ligase complex|nucleus|cytoplasm
YMR201C	YMR201C	RAD14	hom	Verified	0.679923000963744	0.248276608440528	no	1217	0.255753227372252	893	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		Protein that recognizes and binds damaged DNA during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); contains zinc finger motif; homolog of human XPA protein	nucleotide-excision repair, DNA damage recognition	damaged DNA binding|zinc ion binding	nucleotide-excision repair factor 1 complex|nucleus
YGL016W	YGL016W	KAP122	hom	Verified	0.679640015697152	0.248366212878549	no	1218	0.244019261294616	838	NA	FT	PROTEIN LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	Karyopherin beta, responsible for import of the Toa1p-Toa2p complex into the nucleus; binds to nucleoporins Nup1p and Nup2p; may play a role in regulation of pleiotropic drug resistance	protein import into nucleus|regulation of cell size	protein transporter activity	integral to membrane|nuclear pore|cytoplasm
YDL121C_p	YDL121C	YDL121C	hom	Uncharacterized	0.679637208375943	0.248367101874914	no	1219	0.228995791054132	737	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDL121C is not an essential protein	biological_process	molecular_function	endoplasmic reticulum
YDL202W	YDL202W	MRPL11	hom	Verified	0.679586798482574	0.248383065499681	no	1220	0.253326315258087	879	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YMR084W_p	YMR084W	YMR084W	hom	Uncharacterized	0.679406889552378	0.248440042875014	no	1221	0.250849901793946	869	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Putative protein of unknown function; YMR084W and adjacent ORF YMR085W are merged in related strains, and together are paralogous to glutamine-fructose-6-phosphate amidotransferase GFA1	biological_process	molecular_function	cellular_component
YDR465C	YDR465C	RMT2	hom	Verified	0.679205568127147	0.248503809870918	no	1222	0.274497310750705	916	NA	FT		NUCLEUS		Arginine N5 methyltransferase; methylates ribosomal protein Rpl12 (L12) on Arg67; relative distribution to the nucleus increases upon DNA replication stress	peptidyl-arginine methylation	protein-arginine N5-methyltransferase activity	nucleus|cytoplasm
YHR131C_p	YHR131C	YHR131C	hom	Uncharacterized	0.678389593101719	0.248762352896283	no	1223	0.222990351545366	743	NA					Putative protein of unknown function; GFP-fusion protein localizes to the cytoplasm; overexpression causes cell cycle delay or arrest; contains a PH domain and binds phosphatidylinositols and other lipids in a large-scale study	biological_process	molecular_function	cytoplasm
YER093C-A	YER093C-A	AIM11	hom	Verified	0.678042139313782	0.248872487661614	no	1224	0.243082453218807	845	NA					Protein of unknown function; null mutant is viable but shows increased loss of mitochondrial genome and synthetic interaction with prohibitin (phb1); contains an intron; YER093C-A has a paralog, YBL059W, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YML074C	YML074C	FPR3	hom	Verified	0.677719289581175	0.248974846772365	no	1225	0.226545834632922	746	NA	FT	CELL CYCLE|CHROMATIN ORGANIZATION	NUCLEUS		Nucleolar peptidyl-prolyl cis-trans isomerase (PPIase); FK506 binding protein; phosphorylated by casein kinase II (Cka1p-Cka2p-Ckb1p-Ckb2p) and dephosphorylated by Ptp1p	meiotic recombination checkpoint	peptidyl-prolyl cis-trans isomerase activity|macrolide binding	nucleolus
YJL046W	YJL046W	AIM22	hom	Verified	0.677660501800846	0.248993487776638	no	1226	0.247731564645912	827	NA	FT		MITOCHONDRION		Putative lipoate-protein ligase, required along with Lip2 and Lip5 for lipoylation of Lat1p and Kgd2p; similar to E. coli LplA; null mutant displays reduced frequency of mitochondrial genome loss	protein lipoylation	lipoate-protein ligase activity	mitochondrion
YLR058C	YLR058C	SHM2	hom	Verified	0.677227910352836	0.249130680939531	no	1227	0.244488380142283	809	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	SITE OF POLARIZED GROWTH		Cytosolic serine hydroxymethyltransferase, converts serine to glycine plus 5,10 methylenetetrahydrofolate; major isoform involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis	one-carbon metabolic process	glycine hydroxymethyltransferase activity	plasma membrane|mating projection tip|cytoplasm
YKL011C	YKL011C	CCE1	hom	Verified	0.677152588450188	0.249154572830565	no	1228	0.258643137720487	901	NA	FT	MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial cruciform cutting endonuclease, cleaves Holliday junctions formed during recombination of mitochondrial DNA	mitochondrial genome maintenance	endodeoxyribonuclease activity	mitochondrial inner membrane
YNL180C	YNL180C	RHO5	hom	Verified	0.676304611801787	0.249423632654743	no	1229	0.251876215131257	859	NA	FT	SIGNALING	NUCLEUS|PLASMA MEMBRANE		Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely involved in protein kinase C (Pkc1p)-dependent signal transduction pathway that controls cell integrity	Rho protein signal transduction	GTPase activity	endomembrane system|fungal-type vacuole membrane|plasma membrane|nucleus|cytoplasm
YGR250C	YGR250C	YGR250C	hom	Verified	0.675729279930161	0.249606271201643	no	1230	0.254239698431756	862	NA					Putative RNA binding protein; localizes to stress granules induced by glucose deprivation; interacts with Rbg1p in a two-hybrid assay; protein abundance increases in response to DNA replication stress	biological_process	RNA binding	cytoplasmic stress granule|cytoplasm
YKL085W	YKL085W	MDH1	hom	Verified	0.675340406068418	0.249729759058906	no	1231	0.255441765507997	865	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Mitochondrial malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the tricarboxylic acid (TCA) cycle; phosphorylated	chronological cell aging|replicative cell aging|tricarboxylic acid cycle|aerobic respiration	L-malate dehydrogenase activity|mRNA binding	mitochondrion|mitochondrial matrix
YMR225C	YMR225C	MRPL44	hom	Verified	0.675310153054155	0.249739367338407	no	1232	0.248994489034282	851	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YBR113W_d	YBR113W	YBR113W	hom	Dubious	0.674972029677739	0.249846767809181	no	1233	0.216074916191979	734	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CYC8	Unknown	Unknown	Unknown
YCL040W	YCL040W	GLK1	hom	Verified	0.67472116402685	0.249926467845472	no	1234	0.255240000717234	859	NA	FT	CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY			Glucokinase; catalyzes the phosphorylation of glucose at C6 in the first irreversible step of glucose metabolism; one of three glucose phosphorylating enzymes; expression regulated by non-fermentable carbon sources; GLK1 has a paralog, EMI2, that arose from the whole genome duplication	glucose import|mannose metabolic process|glycolysis|glucose metabolic process	glucokinase activity	cytosol|plasma membrane
YNR051C	YNR051C	BRE5	hom	Verified	0.674693795644844	0.249935163598778	no	1235	0.248562158075212	879	NA	FT	VESICLE-MEDIATED TRANSPORT			Ubiquitin protease cofactor, forms deubiquitination complex with Ubp3p that coregulates anterograde and retrograde transport between the endoplasmic reticulum and Golgi compartments; null is sensitive to brefeldin A	protein deubiquitination|ribophagy|regulation of ER to Golgi vesicle-mediated transport|Unknown	molecular_function	cytoplasm
YJL211C_d	YJL211C	YJL211C	hom	Dubious	0.674661753781746	0.249945344460811	no	1236	0.249212806594218	845	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL210W/PEX2	Unknown	Unknown	Unknown
YGR032W	YGR032W	GSC2	hom	Verified	0.673947059452095	0.250172485962584	no	1237	0.229908597112414	792	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	PLASMA MEMBRANE|CYTOSKELETON		Catalytic subunit of 1,3-beta-glucan synthase, involved in formation of the inner layer of the spore wall; activity positively regulated by Rho1p and negatively by Smk1p; has similarity to an alternate catalytic subunit, Fks1p (Gsc1p)	ascospore wall assembly|(1->3)-beta-D-glucan biosynthetic process	1,3-beta-D-glucan synthase activity	1,3-beta-D-glucan synthase complex|integral to membrane|actin cap|prospore membrane
YGL152C_d	YGL152C	YGL152C	hom	Dubious	0.673558633678116	0.250295979905274	no	1238	0.264781448817694	879	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF PEX14/YGL153W	Unknown	Unknown	Unknown
YOL031C	YOL031C	SIL1	hom	Verified	0.673551126428268	0.250298367037115	no	1239	0.237886827044978	830	NA	FT	PROTEIN LOCALIZATION	ENDOPLASMIC RETICULUM		Nucleotide exchange factor for the endoplasmic reticulum (ER) lumenal Hsp70 chaperone Kar2p, required for protein translocation into the ER; homolog of Yarrowia lipolytica SLS1; GrpE-like protein	SRP-dependent cotranslational protein targeting to membrane, translocation	adenyl-nucleotide exchange factor activity	endoplasmic reticulum
YKL134C	YKL134C	OCT1	hom	Verified	0.673547249956127	0.250299599670335	no	1240	0.248737559088247	852	NA	FT	PROTEIN LOCALIZATION|ION HOMEOSTASIS|PROTEOLYSIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS	MITOCHONDRION		Mitochondrial intermediate peptidase, cleaves destabilizing N-terminal residues of a subset of proteins upon import, after their cleavage by mitochondrial processing peptidase (Mas1p-Mas2p); may contribute to mitochondrial iron homeostasis	cellular iron ion homeostasis|protein processing involved in protein targeting to mitochondrion	metalloendopeptidase activity	mitochondrion
YMR031C	YMR031C	EIS1	hom	Verified	0.672454219054229	0.250647287906644	no	1241	0.261479416239856	858	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS	MITOCHONDRION|PLASMA MEMBRANE		Component of the eisosome required for proper eisosome assembly; similarity to Ykl050cp and Uso1p; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; protein increases in abundance and relocalizes from plasma membrane to cytoplasm upon DNA replication stress	eisosome assembly	molecular_function	eisosome|mitochondrion|membrane raft|cytoplasm
YBR266C_d	YBR266C	SLM6	hom	Dubious	0.670730416143171	0.251196141321666	no	1242	0.259509437135134	858	NA					Protein with a potential role in actin cytoskeleton organization; gene exhibits synthetic genetic interaction with MSS4 encoding phosphatidylinositol 4-phosphate kinase	Unknown	Unknown	Unknown
YJL166W	YJL166W	QCR8	hom	Verified	0.670386822243205	0.251305616459295	no	1243	0.235974375116026	757	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p	mitochondrial electron transport, ubiquinol to cytochrome c|aerobic respiration	ubiquinol-cytochrome-c reductase activity	mitochondrion|integral to membrane|mitochondrial respiratory chain complex III
YLR039C	YLR039C	RIC1	hom	Verified	0.670343904586255	0.251319292561317	no	1244	0.350100689118229	1168	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|NUCLEUS|GOLGI APPARATUS		Protein involved in retrograde transport to the cis-Golgi network; forms heterodimer with Rgp1p that acts as a GTP exchange factor for Ypt6p; involved in transcription of rRNA and ribosomal protein genes	intracellular protein transport|retrograde transport, endosome to Golgi	guanyl-nucleotide exchange factor activity	nucleus|Ric1p-Rgp1p complex|Golgi membrane|guanyl-nucleotide exchange factor complex
YOL147C	YOL147C	PEX11	hom	Verified	0.670198141593492	0.251365744203088	no	1245	0.233571754394233	787	NA	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|PEROXISOME ORGANIZATION	ENDOPLASMIC RETICULUM		Peroxisomal membrane protein required for medium-chain fatty acid oxidation and peroxisome proliferation, possibly by inducing membrane curvature; localization regulated by phosphorylation; transcription regulated by Adr1p and Pip2p-Oaf1p	peroxisome fission|fatty acid oxidation	molecular_function	endoplasmic reticulum|peroxisomal membrane
YGR110W	YGR110W	CLD1	hom	Verified	0.670096210383079	0.251398230261516	no	1246	0.265382226755039	887	NA	FT	LIPID METABOLISM	MITOCHONDRION		Mitochondrial cardiolipin-specific phospholipase; functions upstream of Taz1p to generate monolyso-cardiolipin; transcription increases upon genotoxic stress; involved in restricting Ty1 transposition; has homology to mammalian CGI-58	cardiolipin acyl-chain remodeling|cardiolipin metabolic process	phospholipase A2 activity	mitochondrion
YDR471W	YDR471W	RPL27B	hom	Verified	0.669396033203694	0.2516214406869	no	1247	0.247243482622936	843	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L27B; homologous to mammalian ribosomal protein L27, no bacterial homolog; RPL27B has a paralog, RPL27A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YLR264C-A_p	YLR264C-A	YLR264C-A	hom	Uncharacterized	0.669384999039904	0.251624959120512	no	1248	0.25118060602006	864	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YLR285C-A_p	YLR285C-A	YLR285C-A	hom	Uncharacterized	0.669367267604457	0.251630613149245	no	1249	0.237941906558985	799	NA					Putative protein of unknown function; identified by fungal homology and RT-PCR	biological_process	molecular_function	cellular_component
YLR283W_p	YLR283W	YLR283W	hom	Uncharacterized	0.669164420178476	0.251695299950481	no	1250	0.233878698504326	784	NA	FT		MITOCHONDRION		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR283W is not an essential gene	biological_process	molecular_function	mitochondrion
YDR147W	YDR147W	EKI1	hom	Verified	0.668333183698634	0.251960467873699	no	1251	0.254039874949381	849	NA	FT	LIPID METABOLISM			Ethanolamine kinase; primarily responsible for phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway; exhibits some choline kinase activity, thus contributing to phosphatidylcholine synthesis via the CDP-choline pathway; EKI1 has a paralog, CKI1, that arose from the whole genome duplication	phosphatidylethanolamine biosynthetic process|phosphatidylcholine biosynthetic process	ethanolamine kinase activity|choline kinase activity	cytoplasm
YER044C-A	YER044C-A	MEI4	hom	Verified	0.667993046248931	0.25206901563688	no	1252	0.233734209977043	809	NA	FT	CELL CYCLE	NUCLEUS|CHROMOSOME		Meiosis-specific protein involved in double-strand break formation during meiotic recombination; required for chromosome synapsis and production of viable spores	meiotic DNA double-strand break formation	molecular_function	condensed nuclear chromosome
YML079W_p	YML079W	YML079W	hom	Uncharacterized	0.667757515706138	0.252144194744525	no	1253	0.256641152780286	835	NA	FT		NUCLEUS		Non-essential protein of unknown function with structural resemblance to plant storage and ligand binding proteins (canavalin, glycinin, auxin binding protein) and to some enzymes (epimerase, germin); localizes to the nucleus and cytoplasm	biological_process	molecular_function	nucleus|cytoplasm
YJR054W	YJR054W	KCH1	hom	Verified	0.667659419887184	0.252175509484519	no	1254	0.236368757443257	779	NA					Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate	biological_process	molecular_function	integral to membrane|fungal-type vacuole
YBR064W_d	YBR064W	YBR064W	hom	Dubious	0.66756124246845	0.25220685232686	no	1255	0.233295791647399	817	NA					Dubious open reading frame unlikely to encode a protein; partially overlaps the uncharacterized ORF YBR063C	Unknown	Unknown	Unknown
YEL001C	YEL001C	IRC22	hom	Verified	0.667551023137195	0.252210114935329	no	1256	0.225015570144988	767	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Putative protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; YEL001C is non-essential; null mutant displays increased levels of spontaneous Rad52p foci	biological_process	molecular_function	endoplasmic reticulum
YKL150W	YKL150W	MCR1	hom	Verified	0.667145741983985	0.252339522334735	no	1257	0.285636613703407	983	NA	FT	LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS	MITOCHONDRION		Mitochondrial NADH-cytochrome b5 reductase, involved in ergosterol biosynthesis	ergosterol biosynthetic process|cellular response to oxidative stress	cytochrome-b5 reductase activity	mitochondrial outer membrane|mitochondrion|integral to mitochondrial outer membrane|mitochondrial intermembrane space
YPR091C	YPR091C	NVJ2	hom	Verified	0.665722693912139	0.252794182620788	no	1258	0.229285999518355	767	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Lipid-binding ER protein, enriched at nucleus-vacuolar junctions (NVJ); may be involved in sterol metabolism or signaling at the NVJ; contains a synaptotagmin-like-mitochondrial- lipid binding protein (SMP) domain; binds phosphatidylinositols and other lipids in a large-scale study; may interact with ribosomes, based on co-purification experiments	biological_process	lipid binding	ribosome|nucleus-vacuole junction|endoplasmic reticulum
YMR032W	YMR032W	HOF1	hom	Verified	0.665498465314115	0.252865862408148	no	1259	0.257432269495375	913	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CELL DIVISION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Bud neck-localized, SH3 domain-containing protein required for cytokinesis; is phosphorylated by Dbf2p; regulates actomyosin ring dynamics and septin localization; interacts with the formins, Bni1p and Bnr1p, and with Cyk3p, Vrp1p, and Bni5p	cytokinesis after mitosis|barrier septum assembly involved in cell cycle cytokinesis|response to DNA damage stimulus|cytokinesis	cytoskeletal protein binding	cellular bud neck contractile ring|cellular bud neck septin ring
YIL007C	YIL007C	NAS2	hom	Verified	0.665276724249703	0.25293675751842	no	1260	0.224204627934484	779	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS	NUCLEUS		Proteasome-interacting protein; involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); similar to mammalian proteasomal modulator subunit; non-essential gene; interacts with Rpn4p; protein abundance increases in response to DNA replication stress	proteasome regulatory particle assembly|ubiquitin-dependent protein catabolic process	molecular_function	cytosol|nucleus|cytoplasm
YNR033W	YNR033W	ABZ1	hom	Verified	0.665232124138492	0.252951018340958	no	1261	0.227991182015709	760	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM			Para-aminobenzoate (PABA) synthase; has similarity to Escherichia coli PABA synthase components PabA and PabB; required for the synthesis of para-aminobenzoic acid, an important intermediate for folate and ubiquinone Q biosynthesis; protein abundance increases in response to DNA replication stress	para-aminobenzoic acid biosynthetic process	4-amino-4-deoxychorismate synthase activity	cytoplasm
YLR151C	YLR151C	PCD1	hom	Verified	0.664708152994792	0.253118589054295	no	1262	0.251751978820045	863	NA	FT	NUCLEOTIDE METABOLISM			Peroxisomal pyrophosphatase with specificity for coenzyme A and CoA derivatives, may function to remove potentially toxic oxidized CoA disulfide from peroxisomes to maintain the capacity for beta-oxidation of fatty acids; nudix hydrolase family member	biological_process	pyrophosphatase activity	peroxisome
YJL180C	YJL180C	ATP12	hom	Verified	0.66418767758191	0.253285099591489	no	1263	0.254442061462783	897	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Conserved protein required for assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase; mutation of human ATP12 reduces active ATP synthase levels and is associated with the disorder ATPAF2 deficiency	mitochondrial proton-transporting ATP synthase complex assembly	protein domain specific binding	mitochondrion
YDR121W	YDR121W	DPB4	hom	Verified	0.66362048590971	0.253466621151979	no	1264	0.264351691688767	894	NA	FT	GENE SILENCING	NUCLEUS|CHROMOSOME		Subunit of DNA pol epsilon and of ISW2 chromatin accessibility complex; involved in both chromosomal DNA replication and inheritance of telomeric silencing; stabilizes the interaction of Pol epsilon with primer-template DNA, positively affecting the processivity of the polymerase and exonuclease activities of Pol epsilon; interacts with extranucleosomal DNA and acts as anchor point for ISW2 complex that retains its position on DNA during nucleosome mobilization	DNA-dependent DNA replication|chromatin silencing at telomere	double-stranded DNA binding|single-stranded DNA binding|DNA-directed DNA polymerase activity	chromatin accessibility complex|epsilon DNA polymerase complex
YOR208W	YOR208W	PTP2	hom	Verified	0.663620184215192	0.25346671772317	no	1265	0.242848626548131	858	NA	FT	PROTEIN LOCALIZATION|SIGNALING|PROTEIN PHOSPHORYLATION	NUCLEUS		Phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing; dephosporylates Hog1p MAPK and regulates its localization; localized to the nucleus	inactivation of MAPK activity involved in osmosensory signaling pathway|inactivation of MAPK activity involved in cell wall biogenesis|regulation of sporulation|regulation of protein localization|protein dephosphorylation	protein tyrosine phosphatase activity	nucleus
YJR109C	YJR109C	CPA2	hom	Verified	0.662796296035575	0.253730513091447	no	1266	0.229135800128039	764	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Large subunit of carbamoyl phosphate synthetase, which catalyzes a step in the synthesis of citrulline, an arginine precursor	arginine biosynthetic process	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity	carbamoyl-phosphate synthase complex
YDR386W	YDR386W	MUS81	hom	Verified	0.66199660043067	0.253986700204002	no	1267	0.3037597841138	1048	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION	NUCLEUS		Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in DNA repair, replication fork stability, and joint molecule formation/resolution during meiotic recombination; helix-hairpin-helix protein; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates the function of Mms4p-Mus81p	DNA repair|DNA topological change|reciprocal meiotic recombination|resolution of meiotic recombination intermediates|response to DNA damage stimulus	crossover junction endodeoxyribonuclease activity|endonuclease activity	Holliday junction resolvase complex|nucleus
YJL163C_p	YJL163C	YJL163C	hom	Uncharacterized	0.661908558684402	0.254014913178176	no	1268	0.24286948219562	829	NA					Putative protein of unknown function	biological_process	molecular_function	integral to membrane
YPL189C-A	YPL189C-A	COA2	hom	Verified	0.660638016269587	0.254422241454118	no	1269	0.250313435772708	831	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Cytochrome oxidase assembly factor; null mutation results in respiratory deficiency with specific loss of cytochrome oxidase activity; functions downstream of assembly factors Mss51p and Coa1p and interacts with assembly factor Shy1p	mitochondrial respiratory chain complex IV assembly	molecular_function	mitochondrial matrix
YDR068W	YDR068W	DOS2	hom	Verified	0.660283233989479	0.254536043631058	no	1270	0.227096009460233	783	NA					Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	biological_process	molecular_function	cytoplasm
YIL018W	YIL018W	RPL2B	hom	Verified	0.66021389178093	0.254558289385416	no	1271	0.234545943861324	783	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L2B; homologous to mammalian ribosomal protein L2 and bacterial L2; RPL2B has a paralog, RPL2A, that arose from the whole genome duplication; expression is upregulated at low temperatures	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YER139C	YER139C	RTR1	hom	Verified	0.659475332479178	0.254795290631037	no	1272	0.242308866998222	851	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		CTD phosphatase; dephosphorylates S5-P in the C-terminal domain of Rpo21p; has a cysteine-rich motif required for function and conserved in eukaryotes; shuttles between the nucleus and cytoplasm; RTR1 has a paralog, RTR2, that arose from the whole genome duplication	dephosphorylation of RNA polymerase II C-terminal domain|transcription from RNA polymerase II promoter	CTD phosphatase activity	nucleus|cytoplasm
YDR385W	YDR385W	EFT2	hom	Verified	0.659330358188906	0.254841825961933	no	1273	0.245652558195459	839	NA	FT	TRANSLATION|NUCLEOTIDE METABOLISM		RIBOSOME	Elongation factor 2 (EF-2), also encoded by EFT1; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin; EFT2 has a paralog, EFT1, that arose from the whole genome duplication	translational elongation|positive regulation of translational elongation	translation elongation factor activity	ribosome
YLR040C_p	YLR040C	YLR040C	hom	Uncharacterized	0.65858869338935	0.255079962694191	no	1274	0.260575120496306	871	NA					Protein of unknown function; localizes to the cell wall; predicted to be a GPI-attached protein; upregulated by Mcm1p-Alpha1p transcription factor; partially overlaps the dubious ORF YLR041W; mRNA identified as translated by ribosome profiling data; YLR040C is not essential	biological_process	molecular_function	fungal-type cell wall
YDL243C	YDL243C	AAD4	hom	Verified	0.65829369462192	0.255174714437221	no	1275	0.248083057449807	853	NA	FT	OXIDATION-REDUCTION PROCESS			Putative aryl-alcohol dehydrogenase; involved in oxidative stress response; similar to P. chrysosporium aryl-alcohol dehydrogenase; expression induced in cells treated with the mycotoxin patulin	cellular aldehyde metabolic process	aryl-alcohol dehydrogenase (NAD+) activity	cellular_component
YKL216W	YKL216W	URA1	hom	Verified	0.658223666409275	0.255197209760201	no	1276	0.242452181967488	840	NA	FT	OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM			Dihydroorotate dehydrogenase, catalyzes the fourth enzymatic step in the de novo biosynthesis of pyrimidines, converting dihydroorotic acid into orotic acid	'de novo' pyrimidine nucleobase biosynthetic process	dihydroorotate dehydrogenase activity	extrinsic to membrane|cytoplasm
YKL160W	YKL160W	ELF1	hom	Verified	0.65763931359532	0.255384963173379	no	1277	0.243662422201467	830	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION	NUCLEUS		Transcription elongation factor that contains a conserved zinc finger domain; implicated in the maintenance of proper chromatin structure in actively transcribed regions; deletion inhibits Brome mosaic virus (BMV) gene expression	regulation of transcription by chromatin organization|transcription elongation from RNA polymerase II promoter	RNA polymerase II core binding	transcription elongation factor complex|nucleus
YKR044W	YKR044W	UIP5	hom	Verified	0.656756243840991	0.255668831696048	no	1278	0.246296029805578	836	NA	FT		ENDOMEMBRANE SYSTEM|NUCLEUS		Protein of unknown function that interacts with Ulp1p, a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates	biological_process	molecular_function	nuclear envelope
YBR219C_p	YBR219C	YBR219C	hom	Uncharacterized	0.656528251465738	0.255742148082078	no	1279	0.252926735327674	834	NA					Putative protein of unknown function; YBR219C is not an essential gene	biological_process	molecular_function	integral to membrane
YLR320W	YLR320W	MMS22	hom	Verified	0.65643190419579	0.255773134143754	no	1280	0.257144601764963	896	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION	NUCLEUS	UBIQUITIN LIGASE COMPLEX	Subunit of an E3 ubiquitin ligase complex involved in replication repair; stabilizes protein components of the replication fork, such as the fork-pausing complex and leading strand polymerase, preventing fork collapse and promoting efficient recovery during replication stress; required for accurate meiotic chromosome segregation	replication fork processing|double-strand break repair|recombinational repair|meiotic sister chromatid segregation|response to DNA damage stimulus	molecular_function	Cul8-RING ubiquitin ligase complex|nucleus
YER122C	YER122C	GLO3	hom	Verified	0.656329477908264	0.255806077415839	no	1281	0.259538232438384	893	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING|NUCLEOTIDE METABOLISM	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Gcs1p	retrograde vesicle-mediated transport, Golgi to ER|COPI coating of Golgi vesicle|ER to Golgi vesicle-mediated transport	ARF GTPase activator activity	COPI-coated vesicle|endoplasmic reticulum-Golgi intermediate compartment|COPI vesicle coat
YDR296W	YDR296W	MHR1	hom	Verified	0.655736929489658	0.255996701675789	no	1282	0.274576358728068	936	NA	FT	MITOCHONDRION ORGANIZATION|RESPONSE TO OXIDATIVE STRESS	NUCLEUS|MITOCHONDRION		Protein involved in homologous recombination in mitochondria; required for recombination-dependent mtDNA partitioning; involved in stimulation of mitochondrial DNA replication in response to oxidative stress	cellular response to oxidative stress|positive regulation of mitochondrial DNA replication|regulation of transcription, DNA-dependent|mitochondrial genome maintenance|DNA recombination	single-stranded DNA binding|recombinase activity|DNA binding	mitochondrion|nucleus
YLR372W	YLR372W	SUR4	hom	Verified	0.655601379614296	0.256040318811877	no	1283	0.404088949864688	1327	NA	FF|FT	VESICLE-MEDIATED TRANSPORT|KETONE METABOLISM|LIPID METABOLISM	ENDOPLASMIC RETICULUM		Elongase, involved in fatty acid and sphingolipid biosynthesis; synthesizes very long chain 20-26-carbon fatty acids from C18-CoA primers; involved in regulation of sphingolipid biosynthesis	post-Golgi vesicle-mediated transport|fatty acid elongation|fatty acid biosynthetic process|sphingolipid biosynthetic process	fatty acid elongase activity	integral to membrane|endoplasmic reticulum
YNL264C	YNL264C	PDR17	hom	Verified	0.65547109302805	0.256082245984227	no	1284	0.259655457811747	902	NA	FT	LIPID METABOLISM			Phosphatidylinositol transfer protein (PITP), downregulates Plb1p-mediated turnover of phosphatidylcholine, found in the cytosol and microsomes, homologous to Pdr16p, deletion affects phospholipid composition	Golgi to plasma membrane protein transport|phosphatidylserine metabolic process|response to drug|sterol biosynthetic process|Unknown|phospholipid transport|phospholipid biosynthetic process	phosphatidylinositol transporter activity|phosphatidylcholine transporter activity	endosome|cell periphery|cytosol|cytoplasm
YOR231W	YOR231W	MKK1	hom	Verified	0.654007827918823	0.256553381197199	no	1285	0.256046229209051	907	NA	FT	SIGNALING|PROTEIN PHOSPHORYLATION|PEROXISOME ORGANIZATION	SITE OF POLARIZED GROWTH		MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication	signal transduction|peroxisome degradation|protein phosphorylation	protein kinase activity|MAP kinase kinase activity	cellular bud tip
YNL311C	YNL311C	SKP2	hom	Verified	0.653495287052838	0.25671851339591	no	1286	0.249250205481654	833	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|PROTEOLYSIS		UBIQUITIN LIGASE COMPLEX	F-box protein of unknown function predicted to be part of an SCF ubiquitin protease complex; involved in regulating protein levels of sulfur metabolism enzymes; may interact with ribosomes, based on co-purification experiments	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|cellular protein catabolic process|regulation of sulfur amino acid metabolic process	ubiquitin-protein ligase activity|protein binding, bridging	ribosome|SCF ubiquitin ligase complex
YMR269W	YMR269W	TMA23	hom	Verified	0.653426170639891	0.256740785795642	no	1287	0.256828054289077	899	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS	NUCLEUS		Nucleolar protein implicated in ribosome biogenesis; deletion extends chronological lifespan	ribosomal small subunit biogenesis	molecular_function	ribosome|nucleolus
YOR028C	YOR028C	CIN5	hom	Verified	0.652748116690612	0.256959338436151	no	1288	0.229914478824777	759	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Basic leucine zipper (bZIP) transcription factor of the yAP-1 family; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; mediates pleiotropic drug resistance and salt tolerance; nuclearly localized under oxidative stress and sequestered in the cytoplasm by Lot6p under reducing conditions; CIN5 has a paralog, YAP6, that arose from the whole genome duplication	hyperosmotic salinity response|response to drug|hyperosmotic response|regulation of transcription from RNA polymerase II promoter	repressing transcription factor binding|sequence-specific DNA binding	nucleus|cytoplasm
YMR159C	YMR159C	ATG16	hom	Verified	0.652538969502401	0.257026770991779	no	1289	0.256086478779807	903	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS			Conserved protein involved in autophagy; interacts with Atg12p-Atg5p conjugates to form Atg12p-Atg5p-Atg16p multimers, which localize to the pre-autophagosomal structure and are required for autophagy; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress	C-terminal protein lipidation|piecemeal microautophagy of nucleus|mitochondrion degradation|macroautophagy|CVT pathway	protein binding, bridging|Atg8 ligase activity	Atg12-Atg5-Atg16 complex|pre-autophagosomal structure
YMR157C	YMR157C	AIM36	hom	Verified	0.652406143857911	0.257069600982383	no	1290	0.25278973307403	881	NA	FT		MITOCHONDRION		Protein of unknown function; null mutant displays reduced respiratory growth and elevated frequency of mitochondrial genome loss; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YNL299W	YNL299W	TRF5	hom	Verified	0.6522149928178	0.257131244669684	no	1291	0.268872900929373	947	NA	FT	CELL CYCLE|RNA PROCESSING|CELL DIVISION	NUCLEUS		Non-canonical poly(A) polymerase, involved in nuclear RNA degradation as a component of the TRAMP complex; catalyzes polyadenylation of hypomodified tRNAs, and snoRNA and rRNA precursors; overlapping but non-redundant functions with Pap2p	nuclear polyadenylation-dependent CUT catabolic process|nuclear polyadenylation-dependent tRNA catabolic process|nuclear polyadenylation-dependent snoRNA catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|nuclear polyadenylation-dependent snRNA catabolic process|ncRNA polyadenylation|histone mRNA catabolic process|nuclear polyadenylation-dependent mRNA catabolic process|U4 snRNA 3'-end processing|polyadenylation-dependent snoRNA 3'-end processing|snoRNA polyadenylation	polynucleotide adenylyltransferase activity	nucleolus|TRAMP complex
YLR342W-A_p	YLR342W-A	YLR342W-A	hom	Uncharacterized	0.650964698784539	0.25753463747691	no	1292	0.25552627971619	885	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YLR017W	YLR017W	MEU1	hom	Verified	0.650872824606489	0.257564292569292	no	1293	0.239016046067361	810	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Methylthioadenosine phosphorylase (MTAP), catalyzes the initial step in the methionine salvage pathway; affects polyamine biosynthesis through regulation of ornithine decarboxylase (Spe1p) activity; regulates ADH2 gene expression	L-methionine salvage from methylthioadenosine|glutamate biosynthetic process	S-methyl-5-thioadenosine phosphorylase activity|mRNA binding	cytoplasm
YOR009W	YOR009W	TIR4	hom	Verified	0.650744149902707	0.257605829094528	no	1294	0.254049122129578	878	NA	FT	CELL WALL ORG/BIOGENESIS			Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expressed under anaerobic conditions and required for anaerobic growth; transcription is also induced by cold shock	biological_process	molecular_function	fungal-type cell wall
YIL076W	YIL076W	SEC28	hom	Verified	0.648779949608506	0.258240309547541	no	1295	0.247885372156677	862	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Epsilon-COP subunit of the coatomer; regulates retrograde Golgi-to-ER protein traffic; stabilizes Cop1p, the alpha-COP and the coatomer complex; non-essential for cell growth; protein abundance increases in response to DNA replication stress	late endosome to vacuole transport via multivesicular body sorting pathway|ER to Golgi vesicle-mediated transport|vesicle coating	molecular_function	endosome|COPI vesicle coat
YKL138C	YKL138C	MRPL31	hom	Verified	0.648760679125567	0.258246538352849	no	1296	0.270848173489219	932	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation	structural constituent of ribosome	mitochondrial large ribosomal subunit
YMR205C	YMR205C	PFK2	hom	Verified	0.648758054560498	0.258247386698011	no	1297	0.37113010503849	1225	NA	FT	CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Beta subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes	proton transport|glycolysis	mRNA binding|6-phosphofructokinase activity	mitochondrion|6-phosphofructokinase complex|cytoplasm
YKL142W	YKL142W	MRP8	hom	Verified	0.648006575850772	0.258490348568203	no	1298	0.252414178897508	850	NA					Protein of unknown function; undergoes sumoylation; transcription induced under cell wall stress; protein levels are reduced under anaerobic conditions; protein abundance increases in response to DNA replication stress; originally thought to be a mitochondrial ribosomal protein based on sequence analysis	biological_process	molecular_function	cytoplasm
YNL057W_d	YNL057W	YNL057W	hom	Dubious	0.647801220253306	0.258556763030167	no	1299	0.249602900389356	864	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YPL172C	YPL172C	COX10	hom	Verified	0.647245596546252	0.258736502687607	no	1300	0.286984007203976	1005	NA	FT	COFACTOR METABOLISM	MITOCHONDRION		Heme A:farnesyltransferase, catalyzes the first step in the conversion of protoheme to the heme A prosthetic group required for cytochrome c oxidase activity; human ortholog is associated with mitochondrial disorders	heme a biosynthetic process	protoheme IX farnesyltransferase activity	mitochondrion|integral to membrane
YKL151C	YKL151C	YKL151C	hom	Verified	0.646261678213286	0.259054950691389	no	1301	0.224930148448802	747	NA	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM			NADHX dehydratase; converts (S)-NADHX to NADH in an ATP-dependent manner; homologous to Carkd in mammals, and the C-terminal domain of YjeF in E.coli; enzyme is widespread in eukaryotes, prokaryotes and archaea; YKL151C promoter contains STREs (stress response elements) and expression is induced by heat shock or methyl methanesulfonate; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress	nicotinamide nucleotide metabolic process	ATP-dependent NAD(P)H-hydrate dehydratase activity	cytoplasm
YCL028W	YCL028W	RNQ1	hom	Verified	0.645511624638033	0.259297843761923	no	1302	0.239664227300768	848	NA	FT		NUCLEUS		[PIN(+)] prion, an infectious protein conformation that is generally an ordered protein aggregate	biological_process	molecular_function	cytosol
YGL079W_p	YGL079W	KXD1	hom	Uncharacterized	0.644104282142014	0.259753906881744	no	1303	0.247361528362536	828	NA					Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; null mutant is sensitive to drug inducing secretion of vacuolar cargo; GFP-fusion protein localizes to the endosome	biological_process	molecular_function	endosome
YMR006C	YMR006C	PLB2	hom	Verified	0.643729694319244	0.259875365449888	no	1304	0.219470445558692	763	NA	FT	LIPID METABOLISM			Phospholipase B (lysophospholipase) involved in phospholipid metabolism; displays transacylase activity in vitro; overproduction confers resistance to lysophosphatidylcholine	glycerophospholipid metabolic process	lysophospholipase activity	extracellular region|fungal-type cell wall
YDR034W-B_p	YDR034W-B	YDR034W-B	hom	Uncharacterized	0.643381463827959	0.259988304033598	no	1305	0.26746389306718	909	NA					Predicted tail-anchored plasma membrane protein containing a conserved CYSTM module; related proteins in other organisms may be involved in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery	biological_process	molecular_function	cellular_component
YLR351C	YLR351C	NIT3	hom	Verified	0.642383045828962	0.260312252571952	no	1306	0.243070718304252	822	NA	FT		MITOCHONDRION		Nit protein, one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member	biological_process	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	mitochondrion|cytoplasm
YER066W_p	YER066W	RRT13	hom	Uncharacterized	0.642273673265225	0.260347752429217	no	1307	0.228182434741244	808	NA					Putative protein of unknown function; non-essential gene identified in a screen for mutants with decreased levels of rDNA transcription	biological_process	molecular_function	cellular_component
YNR066C_p	YNR066C	YNR066C	hom	Uncharacterized	0.642086797126482	0.260408413962368	no	1308	0.254114215957561	919	NA					Putative membrane-localized protein of unknown function	biological_process	molecular_function	integral to membrane|membrane
YOR305W	YOR305W	RRG7	hom	Verified	0.642059204892879	0.260417371245323	no	1309	0.24226314190079	833	NA	FT		MITOCHONDRION		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO); YOR305W is not an essential gene	biological_process	molecular_function	mitochondrion
YEL025C_p	YEL025C	YEL025C	hom	Uncharacterized	0.64175556669039	0.260515951973492	no	1310	0.222802507552379	743	NA	FT		NUCLEUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus	biological_process	molecular_function	nucleus|cytoplasm
YCL026C-B	YCL026C-B	HBN1	hom	Verified	0.641431345919828	0.260621236352118	no	1311	0.271963923411976	944	NA	FT	OXIDATION-REDUCTION PROCESS	NUCLEUS		Protein of unknown function; similar to bacterial nitroreductases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; protein becomes insoluble upon intracellular iron depletion; protein abundance increases in response to DNA replication stress	biological_process	NAD(P)H nitroreductase activity	nucleus|cytoplasm
YOR223W	YOR223W	YOR223W	hom	Verified	0.641245246980793	0.26068167824911	no	1312	0.259577715202638	891	NA	FT		ENDOPLASMIC RETICULUM		Subunit of the DSC ubiquitin ligase complex; protein of unknown function that localizes to the ER and vacuole lumen; overexpression affects endocytic protein trafficking; ortholog of fission yeast dsc3	biological_process	molecular_function	fungal-type vacuole lumen|endoplasmic reticulum
YML014W	YML014W	TRM9	hom	Verified	0.641127121921984	0.260720047082078	no	1313	0.233189637111047	806	NA	FT	RNA PROCESSING	NUCLEUS		tRNA methyltransferase; catalyzes modification of wobble bases in tRNA anticodons to 2, 5-methoxycarbonylmethyluridine and 5-methoxycarbonylmethyl-2-thiouridine; may act as part of a complex with Trm112p; deletion mutation increases translational infidelity, including amino acid misincorporation and -1 frameshifting, and also confers resistance to zymocin; null mutant displays activation of stress responses	chronological cell aging|tRNA methylation|tRNA wobble uridine modification|response to stress	tRNA (uracil) methyltransferase activity	nucleus|cytoplasm
YGR155W	YGR155W	CYS4	hom	Verified	0.640838170648382	0.260813915140155	no	1314	0.255529916053816	868	NA	FT	KETONE METABOLISM|CELL CYCLE|AMINO ACID METABOLISM	MITOCHONDRION		Cystathionine beta-synthase, catalyzes synthesis of cystathionine from serine and homocysteine, the first committed step in cysteine biosynthesis; responsible for hydrogen sulfide generation; advances passage through START by promoting cell growth which requires catalytic activity, and reducing critical cell size independent of catalytic activity; mutations in human ortholog cause homocystinuria	cysteine biosynthetic process from serine|hydrogen sulfide biosynthetic process|cysteine biosynthetic process via cystathionine|transsulfuration|traversing start control point of mitotic cell cycle	cystathionine beta-synthase activity	mitochondrion|cytoplasm
YOR270C	YOR270C	VPH1	hom	Verified	0.640517196786005	0.2609182063636	no	1315	0.257355922182807	873	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|ION HOMEOSTASIS			Subunit a of vacuolar-ATPase V0 domain; one of two isoforms (Vph1p and Stv1p); Vph1p is located in V-ATPase complexes of the vacuole while Stv1p is located in V-ATPase complexes of the Golgi and endosomes; relative distribution to the vacuolar membrane decreases upon DNA replication stress	polyphosphate metabolic process|proton transport|protein complex assembly|vacuolar acidification	proton-transporting ATPase activity, rotational mechanism	vacuolar proton-transporting V-type ATPase, V0 domain|fungal-type vacuole membrane|integral to membrane|fungal-type vacuole
YLL040C	YLL040C	VPS13	hom	Verified	0.640258955105242	0.261002130135953	no	1316	0.25246223422132	851	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT	MITOCHONDRION|GOLGI APPARATUS		Protein of unknown function; heterooligomeric or homooligomeric complex; peripherally associated with membranes; involved in sporulation, vacuolar protein sorting, prospore membrane formation and protein-Golgi retention; homologous to human CHAC and COH1 which are involved in chorea acanthocytosis and Cohen syndrome, respectively	protein retention in Golgi apparatus|late endosome to vacuole transport|protein targeting to vacuole|ascospore-type prospore membrane assembly	molecular_function	endosome|mitochondrion|prospore membrane|extrinsic to membrane
YMR238W	YMR238W	DFG5	hom	Verified	0.639142814148651	0.261365014876752	no	1317	0.287365633859522	997	NA	FT	CELL WALL ORG/BIOGENESIS|CELL DIVISION|CARBOHYDRATE METABOLISM	PLASMA MEMBRANE		Putative mannosidase, essential glycosylphosphatidylinositol (GPI)-anchored membrane protein required for cell wall biogenesis in bud formation, involved in filamentous growth, homologous to Dcw1p	pseudohyphal growth|fungal-type cell wall biogenesis|budding cell bud growth	mannosidase activity	anchored to plasma membrane
YOL028C	YOL028C	YAP7	hom	Verified	0.639045251322566	0.261396747250569	no	1318	0.267972519147169	919	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Putative basic leucine zipper (bZIP) transcription factor; YAP7 has a paralog, YAP5, that arose from the whole genome duplication	positive regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding	nucleus
YHR071W	YHR071W	PCL5	hom	Verified	0.638566297881437	0.261552555868325	no	1319	0.223143456516292	807	NA	FT	CELL CYCLE|CELL DIVISION|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Cyclin, interacts with and phosphorylated by Pho85p cyclin-dependent kinase (Cdk), induced by Gcn4p at level of transcription, specifically required for Gcn4p degradation, may be sensor of cellular protein biosynthetic capacity	negative regulation of sequence-specific DNA binding transcription factor activity|regulation of protein stability|negative regulation of macroautophagy	cyclin-dependent protein kinase regulator activity	cyclin-dependent protein kinase holoenzyme complex|nucleus
YGR101W	YGR101W	PCP1	hom	Verified	0.638290694613118	0.261642234129602	no	1320	0.274544008268394	952	NA	FT	PROTEOLYSIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial serine protease required for the processing of various mitochondrial proteins and maintenance of mitochondrial DNA and morphology; belongs to the rhomboid-GlpG superfamily of intramembrane peptidases	signal peptide processing|regulation of mitochondrion organization	serine-type endopeptidase activity	integral to membrane|mitochondrial inner membrane
YER101C	YER101C	AST2	hom	Verified	0.638104939910185	0.261702685560096	no	1321	0.267093880716206	926	NA	FT	PROTEIN LOCALIZATION|OXIDATION-REDUCTION PROCESS			Lipid raft associated protein; overexpression restores Pma1p localization to lipid rafts which is required for targeting of Pma1p to the plasma membrane; sometimes classified in the medium-chain dehydrogenase/reductases (MDRs) superfamily; AST2 has a paralog, AST1, that arose from the whole genome duplication	protein targeting to membrane	molecular_function	cytoplasm
YGR174W-A_p	YGR174W-A	YGR174W-A	hom	Uncharacterized	0.638098815338405	0.261704678843646	no	1322	0.238165264500811	809	NA					Putative protein of unknown function; predicted to have a role in cell budding based on computational guilt by association analysis	biological_process	molecular_function	cellular_component
YLR205C	YLR205C	HMX1	hom	Verified	0.636936163324862	0.262083212902281	no	1323	0.232513402784112	766	NA	FT	ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM		ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants	response to oxidative stress|cellular iron ion homeostasis|heme catabolic process	heme oxygenase (decyclizing) activity	endoplasmic reticulum|membrane|nuclear outer membrane
YMR303C	YMR303C	ADH2	hom	Verified	0.636549030688415	0.262209317065773	no	1324	0.258107528379523	901	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM			Glucose-repressible alcohol dehydrogenase II, catalyzes the conversion of ethanol to acetaldehyde; involved in the production of certain carboxylate esters; regulated by ADR1	ethanol metabolic process|NADH oxidation|fermentation|amino acid catabolic process to alcohol via Ehrlich pathway	alcohol dehydrogenase (NAD) activity	cytoplasm
YNL087W	YNL087W	TCB2	hom	Verified	0.636303426989015	0.26228933586135	no	1325	0.263967850363334	904	NA	FT		ENDOPLASMIC RETICULUM|PLASMA MEMBRANE		ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; contains 3 calcium and lipid binding domains; mRNA is targeted to the bud	biological_process	lipid binding	cellular bud|cortical endoplasmic reticulum
YBR151W	YBR151W	APD1	hom	Verified	0.635861834206858	0.262433240241972	no	1326	0.256813726282501	902	NA	FT		NUCLEUS		Protein of unknown function, required for normal localization of actin patches and for normal tolerance of sodium ions and hydrogen peroxide; localizes to both cytoplasm and nucleus	biological_process	molecular_function	nucleus|cytoplasm
YPR093C	YPR093C	ASR1	hom	Verified	0.633739467921356	0.263125431525748	no	1327	0.262516213681292	896	NA	FT		NUCLEUS		Ubiquitin ligase that modifies and regulates RNA Pol II; involved in a putative alcohol-responsive signaling pathway; accumulates in the nucleus under alcohol stress; contains a Ring/PHD finger domain similar to the mammalian rA9 protein	response to ethanol|protein ubiquitination	ubiquitin-protein ligase activity	nucleus|cytoplasm
YDR399W	YDR399W	HPT1	hom	Verified	0.633585204229752	0.263175779627097	no	1328	0.251892093605113	876	NA	FT	NUCLEOTIDE METABOLISM	NUCLEUS		Dimeric hypoxanthine-guanine phosphoribosyltransferase, catalyzes the transfer of the phosphoribosyl portion of 5-phosphoribosyl-alpha-1-pyrophosphate to a purine base (either guanine or hypoxanthine) to form pyrophosphate and a purine nucleotide (either guanosine monophosphate or inosine monophosphate); mutations in the human homolog HPRT1 can cause Lesch-Nyhan syndrome and Kelley-Seegmiller syndrome	GMP salvage|IMP salvage	hypoxanthine phosphoribosyltransferase activity	nucleus|cytoplasm
YPR089W_p	YPR089W	YPR089W	hom	Uncharacterized	0.631752791282344	0.26377421305087	no	1329	0.268872519265665	958	NA	FT		GOLGI APPARATUS		Protein of unknown function; exhibits genetic interaction with ERG11 and protein-protein interaction with Hsp82p	biological_process	molecular_function	cellular_component
YKL051W	YKL051W	SFK1	hom	Verified	0.631364229959558	0.263901199374055	no	1330	0.219027012236542	720	NA	FT	LIPID METABOLISM|SIGNALING|CYTOSKELETON ORGANIZATION	PLASMA MEMBRANE		Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane	vacuole organization|inositol lipid-mediated signaling|actin cytoskeleton organization	molecular_function	integral to membrane|plasma membrane
YAR020C	YAR020C	PAU7	hom	Verified	0.630202692933492	0.26428098880682	no	1331	0.266507998652896	895	NA					Member of the seripauperin multigene family, active during alcoholic fermentation, regulated by anaerobiosis, inhibited by oxygen, repressed by heme	biological_process	molecular_function	cellular_component
YGR021W_p	YGR021W	YGR021W	hom	Uncharacterized	0.629990019060583	0.264350557220368	no	1332	0.274129474277054	951	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YML042W	YML042W	CAT2	hom	Verified	0.628650473539755	0.264788954314513	no	1333	0.254906061256676	831	NA	FT	KETONE METABOLISM|LIPID METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		Carnitine acetyl-CoA transferase present in both mitochondria and peroxisomes, transfers activated acetyl groups to carnitine to form acetylcarnitine which can be shuttled across membranes	carnitine metabolic process	carnitine O-acetyltransferase activity	mitochondrion|peroxisomal matrix|peroxisome
YER005W	YER005W	YND1	hom	Verified	0.625474072372255	0.265829980051037	no	1334	0.262514573550535	899	NA	FT	LIPID METABOLISM|CARBOHYDRATE METABOLISM	GOLGI APPARATUS		Apyrase with wide substrate specificity, helps prevent inhibition of glycosylation by hydrolyzing nucleoside tri- and diphosphates that inhibit glycotransferases; partially redundant with Gda1p; mediates adenovirus E4orf4-induced toxicity	protein glycosylation	nucleoside-triphosphatase activity|nucleoside-diphosphatase activity	COPI-coated vesicle|Golgi apparatus|membrane|Golgi membrane
YKL003C	YKL003C	MRP17	hom	Verified	0.624870354872225	0.266028075242977	no	1335	0.274117238594914	955	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the small subunit; MRP17 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YKR003W	YKR003W	OSH6	hom	Verified	0.624418200972396	0.266176487486798	no	1336	0.242115997185827	881	NA	FT	VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|MEMBRANE ORGANIZATION	ENDOPLASMIC RETICULUM|PLASMA MEMBRANE		Member of an oxysterol-binding protein family; overlapping, redundant functions in sterol metabolism and which collectively perform a function essential for viability; GFP-fusion protein localizes to the cell periphery; overexpression extends lifespan by promoting vacuolar fusion	sterol homeostasis|maintenance of cell polarity|endocytosis|sterol transport|exocytosis|sterol metabolic process	phosphatidic acid binding|lipid binding|phosphatidylinositol-3,4-bisphosphate binding|oxysterol binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-5-phosphate binding|phosphatidylinositol-4-phosphate binding	cortical endoplasmic reticulum|extrinsic to membrane|cytoplasm
YMR170C	YMR170C	ALD2	hom	Verified	0.624196398278541	0.266249305975134	no	1337	0.257380226049056	894	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS			Cytoplasmic aldehyde dehydrogenase, involved in ethanol oxidation and beta-alanine biosynthesis; uses NAD+ as the preferred coenzyme; expression is stress induced and glucose repressed; very similar to Ald3p	cellular aldehyde metabolic process|beta-alanine biosynthetic process|polyamine catabolic process	aldehyde dehydrogenase (NAD) activity	cytoplasm
YER053C	YER053C	PIC2	hom	Verified	0.623278803277732	0.266550662269137	no	1338	0.223999176224712	735	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; functionally redundant with Mir1p but less abundant than Mir1p under normal conditions; expression is induced at high temperature	phosphate ion transport|transmembrane transport	inorganic phosphate transmembrane transporter activity	mitochondrion|integral to membrane
YOL124C	YOL124C	TRM11	hom	Verified	0.621884939670095	0.26700876436132	no	1339	0.268515548333213	908	NA	FT	RNA PROCESSING			Catalytic subunit of an adoMet-dependent tRNA methyltransferase complex (Trm11p-Trm112p), required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs; contains a THUMP domain and a methyltransferase domain	tRNA methylation	S-adenosylmethionine-dependent methyltransferase activity|RNA binding|tRNA (guanine-N2-)-methyltransferase activity	cytoplasm|tRNA (m2G10) methyltransferase complex
YDR042C_p	YDR042C	YDR042C	hom	Uncharacterized	0.621745128903299	0.267054735985496	no	1340	0.243804523312393	803	NA					Putative protein of unknown function; expression is increased in ssu72-ts69 mutant	biological_process	molecular_function	cellular_component
YMR179W	YMR179W	SPT21	hom	Verified	0.620831194422758	0.26735534811879	no	1341	0.281437699784139	977	NA	FT	TRANSCRIPTION FROM RNA POL II|GENE SILENCING	NUCLEUS		Protein with a role in transcriptional silencing; required for normal transcription at several loci including HTA2-HTB2 and HHF2-HHT2, but not required at the other histone loci; functionally related to Spt10p; localizes to nuclear foci that become diffuse upon DNA replication stress	chromatin silencing at rDNA|regulation of transcription from RNA polymerase II promoter|chromatin silencing at telomere|chromatin silencing at silent mating-type cassette	molecular_function	nucleus
YPR167C	YPR167C	MET16	hom	Verified	0.619393541794175	0.267828567307717	no	1342	0.264657011208349	898	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS			3'-phosphoadenylsulfate reductase, reduces 3'-phosphoadenylyl sulfate to adenosine-3',5'-bisphosphate and free sulfite using reduced thioredoxin as cosubstrate, involved in sulfate assimilation and methionine metabolism	sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)|sulfur amino acid metabolic process	phosphoadenylyl-sulfate reductase (thioredoxin) activity	cytoplasm
YDL074C	YDL074C	BRE1	hom	Verified	0.6183954334879	0.268157353622798	no	1343	0.328231174201499	1117	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING	NUCLEUS|CHROMOSOME		E3 ubiquitin ligase, forms heterodimer with Rad6p to monoubiquinate histone H2B-K123, which is required for the subsequent methylation of histone H3-K4 and H3-K79; required for DSBR, transcription, silencing, and checkpoint control	mitotic cell cycle G1/S transition DNA damage checkpoint|intra-S DNA damage checkpoint|meiotic DNA double-strand break formation|histone monoubiquitination|double-strand break repair via homologous recombination|transcription from RNA polymerase II promoter|chromatin silencing at telomere	ubiquitin-protein ligase activity	nuclear chromatin
YML081W	YML081W	TDA9	hom	Verified	0.618325084219139	0.268180534997716	no	1344	0.252253827791461	859	NA	FT		NUCLEUS		DNA-binding protein, putative transcription factor; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; null mutant is sensitive to expression of the top1-T722A allele; not an essential gene; TDA9 has a paralog, RSF2, that arose from the whole genome duplication	biological_process	sequence-specific DNA binding	nucleus
YKL170W	YKL170W	MRPL38	hom	Verified	0.618193008598881	0.268224059061754	no	1345	0.281562812882163	975	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL34 and YmL38) on two-dimensional SDS gels; protein abundance increases in response to DNA replication stress	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YMR073C	YMR073C	IRC21	hom	Verified	0.616766500290382	0.268694375521056	no	1346	0.333676862337415	1117	NA	FF				Putative protein of unknown function; may be involved in resistance to carboplatin and cisplatin; null mutant displays increase in spontaneous Rad52p foci; contains a lipid-binding domain and binds cardiolipin in a large-scale study	response to drug	molecular_function	cytoplasm
YPL168W_p	YPL168W	YPL168W	hom	Uncharacterized	0.614983930649071	0.269282666369071	no	1347	0.275071828429675	915	NA	FT		MITOCHONDRION		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; expression may be cell cycle-regulated	biological_process	molecular_function	mitochondrion
YJL170C	YJL170C	ASG7	hom	Verified	0.613753002558246	0.269689278945056	no	1348	0.278562854098492	947	NA	FT		ENDOMEMBRANE SYSTEM|PLASMA MEMBRANE		Protein that regulates signaling from a G protein beta subunit Ste4p and its relocalization within the cell; specific to a-cells and induced by alpha-factor	conjugation with cellular fusion	molecular_function	plasma membrane
YFL019C_d	YFL019C	YFL019C	hom	Dubious	0.61287396887973	0.269979838319465	no	1349	0.24831808034911	853	NA					Dubious open reading frame unlikely to encode a protein; YFL019C is not an essential gene	Unknown	Unknown	Unknown
YKL037W	YKL037W	AIM26	hom	Verified	0.612631632190938	0.270059968815265	no	1350	0.31417875286413	1078	NA	FF|FT		MITOCHONDRION		Putative protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss; null mutation confers sensitivity to tunicamycin and DTT	mitochondrion degradation	molecular_function	mitochondrion|integral to membrane
YLR068W	YLR068W	FYV7	hom	Verified	0.612299494678906	0.270169811972694	no	1351	0.277653582621612	944	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Essential protein required for maturation of 18S rRNA; required for survival upon exposure to K1 killer toxin	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	molecular_function	nucleolus|nucleus
YNR048W	YNR048W	YNR048W	hom	Verified	0.612000598608157	0.270268680755834	no	1352	0.271662466151196	940	NA					Protein that interacts with phospholipid translocase (flippase) Dnf3p; YNR048W has a paralog, CDC50, that arose from the whole genome duplication	response to drug	phospholipid-translocating ATPase activity	integral to membrane
YPR057W	YPR057W	BRR1	hom	Verified	0.611468969406874	0.270444577649637	no	1353	0.216015125262543	756	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING	NUCLEUS		snRNP protein component of spliceosomal snRNPs, required for pre-mRNA splicing and snRNP biogenesis; in null mutant newly-synthesized snRNAs are destabilized and 3'-end processing is slowed	spliceosomal complex assembly	RNA binding	small nuclear ribonucleoprotein complex
YIL103W	YIL103W	DPH1	hom	Verified	0.610231795923674	0.270854134998473	no	1354	0.265646660253047	925	NA					Protein required, along with Dph2p, Kti11p, Jjj3p, and Dph5p, for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); may act in a complex with Dph2p and Kti11p	peptidyl-diphthamide biosynthetic process from peptidyl-histidine	molecular_function	cytoplasm
YJL134W	YJL134W	LCB3	hom	Verified	0.610175169052925	0.27087288832108	no	1355	0.262943998054491	881	NA	FT	LIPID METABOLISM|SIGNALING	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Long-chain base-1-phosphate phosphatase; specific for dihydrosphingosine-1-phosphate, regulates ceramide and long-chain base phosphates levels, involved in incorporation of exogenous long chain bases in sphingolipids; LCB3 has a paralog, YSR3, that arose from the whole genome duplication	calcium-mediated signaling|sphingolipid biosynthetic process	sphingosine-1-phosphate phosphatase activity	integral to membrane|endoplasmic reticulum
YDL053C	YDL053C	PBP4	hom	Verified	0.609235868766828	0.27118405423506	no	1356	0.277915941668334	963	NA	FT		NUCLEUS		Pbp1p binding protein; interacts strongly with Pab1p-binding protein 1 (Pbp1p) in the yeast two-hybrid system; also interacts with Lsm12p in a copurification assay; relative distribution to the nucleus increases upon DNA replication stress	biological_process	molecular_function	nucleus|cytoplasmic stress granule|cytoplasm
YDL059C	YDL059C	RAD59	hom	Verified	0.608978667934811	0.271269289295793	no	1357	0.288072123420107	996	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		Protein involved DNA double-strand break repair; repairs breaks in DNA during vegetative growth via recombination and single-strand annealing; anneals complementary single-stranded DNA; forms nuclear foci upon DNA replication stress; required for loading of Rad52p to DSBs; paralog of Rad52p	DNA strand renaturation|telomere maintenance via recombination|double-strand break repair via break-induced replication|double-strand break repair via single-strand annealing	protein binding	nucleus
YDR158W	YDR158W	HOM2	hom	Verified	0.608891910237058	0.271298043371567	no	1358	0.301264519025731	1041	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS	NUCLEUS		Aspartic beta semi-aldehyde dehydrogenase, catalyzes the second step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis	methionine biosynthetic process|threonine biosynthetic process|homoserine biosynthetic process	aspartate-semialdehyde dehydrogenase activity	nucleus|plasma membrane|cytoplasm
YNR073C_p	YNR073C	YNR073C	hom	Uncharacterized	0.608324293954156	0.271486205726371	no	1359	0.307759230214588	1033	NA					Putative mannitol dehydrogenase; identical in amino acid sequence to Dsf1p	biological_process	mannitol dehydrogenase activity	cellular_component
YPL215W	YPL215W	CBP3	hom	Verified	0.606266958959524	0.272168747750403	no	1360	0.244902330818479	858	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex	positive regulation of mitochondrial translation|mitochondrial respiratory chain complex III assembly	ribosome binding	integral to mitochondrial membrane|mitochondrion|mitochondrial ribosome
YOL103W	YOL103W	ITR2	hom	Verified	0.60610698551284	0.272221856303296	no	1361	0.275649273255973	938	NA	FT		PLASMA MEMBRANE		Myo-inositol transporter with strong similarity to the major myo-inositol transporter Itr1p, member of the sugar transporter superfamily; expressed constitutively	myo-inositol transport	myo-inositol transmembrane transporter activity	integral to membrane|plasma membrane|membrane
YKL207W	YKL207W	EMC3	hom	Verified	0.605687597746314	0.272361110587862	no	1362	0.255593004366811	884	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; required for respiratory growth; null mutant displays induction of the unfolded protein response; homologous to worm Y62E10A.10/EMC-3, fly CG6750, human TMEM111	protein folding in endoplasmic reticulum	molecular_function	ER membrane protein complex|integral to membrane
YLL009C	YLL009C	COX17	hom	Verified	0.605059328618612	0.272569788414517	no	1363	0.261764364214027	866	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS	MITOCHONDRION		Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs	mitochondrial respiratory chain complex IV assembly|intracellular copper ion transport	copper chaperone activity	cytosol|mitochondrion|mitochondrial intermembrane space
YOR302W	YOR302W	YOR302W	hom	Verified	0.604945285141897	0.272607676144828	no	1364	0.256486318791917	844	NA	FT	TRANSLATION			CPA1 uORF, Arginine attenuator peptide, regulates translation of the CPA1 mRNA	regulation of translation	translation regulator activity	cytosol
YPL177C	YPL177C	CUP9	hom	Verified	0.603985695631186	0.272926576209853	no	1365	0.277890327633413	989	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Homeodomain-containing transcriptional repressor; regulates expression of PTR2, which encodes a major peptide transporter; imported peptides activate ubiquitin-dependent proteolysis, resulting in degradation of Cup9p and de-repression of PTR2 transcription; CUP9 has a paralog, TOS8, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress	negative regulation of dipeptide transport by negative regulation of transcription from RNA polymerase II promoter|negative regulation of oligopeptide transport by negative regulation of transcription from RNA polymerase II promoter	RNA polymerase II repressing transcription factor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity	nucleus
YLR401C	YLR401C	DUS3	hom	Verified	0.603247025790682	0.273172184058498	no	1366	0.216893148931811	725	NA	FT	RNA PROCESSING|OXIDATION-REDUCTION PROCESS	NUCLEUS		Dihydrouridine synthase; member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus4p; contains a consensus oleate response element (ORE) in its promoter region; forms nuclear foci upon DNA replication stress	tRNA modification	tRNA dihydrouridine synthase activity	nucleus|cytoplasm
YMR002W	YMR002W	MIC17	hom	Verified	0.603005714938583	0.273252443684182	no	1367	0.280649812867376	976	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS|MITOCHONDRION		Mitochondrial intermembrane space protein; required for normal oxygen consumption; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress	aerobic respiration	molecular_function	nucleus|cytoplasm|mitochondrial intermembrane space
YCL057C-A	YCL057C-A	MOS1	hom	Verified	0.602979973245535	0.273261006021951	no	1368	0.251750122862016	861	NA	FT	MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial protein essential for proper inner membrane organization; conserved component of the mitochondrial inner membrane organizing system (MICOS, MINOS, or MitOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture; ortholog of human MINOS1	cristae formation	molecular_function	mitochondrion|mitochondrial crista junction|integral to mitochondrial inner membrane
YAL021C	YAL021C	CCR4	hom	Verified	0.600881180859732	0.273959564254963	no	1369	0.322068066313199	1079	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|RNA PROCESSING	NUCLEUS	RNA POL II, HOLOENZYME	Component of the CCR4-NOT transcriptional complex, which is involved in regulation of gene expression; component of the major cytoplasmic deadenylase, which is involved in mRNA poly(A) tail shortening	regulation of transcription from RNA polymerase II promoter|positive regulation of transcription elongation from RNA polymerase II promoter|nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|DNA replication checkpoint|nuclear-transcribed mRNA poly(A) tail shortening|traversing start control point of mitotic cell cycle|replication fork protection|transcription elongation from RNA polymerase II promoter|DNA replication	3'-5'-exoribonuclease activity	CCR4-NOT core complex|cytoplasmic mRNA processing body|Cdc73/Paf1 complex|cytoplasm
YGR181W	YGR181W	TIM13	hom	Verified	0.600813793690915	0.273982007894144	no	1370	0.240506832645742	818	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial intermembrane space protein, forms a complex with Tim8p that delivers a subset of hydrophobic proteins to the TIM22 complex for insertion into the inner membrane	protein import into mitochondrial inner membrane	protein transporter activity	mitochondrion|integral to membrane|mitochondrial intermembrane space protein transporter complex|mitochondrial intermembrane space
YER151C	YER151C	UBP3	hom	Verified	0.600761150066624	0.273999541753093	no	1371	0.299678419514431	1019	NA	FT	VESICLE-MEDIATED TRANSPORT|PROTEOLYSIS			Ubiquitin-specific protease involved in transport and osmotic response; interacts with Bre5p to co-regulate anterograde and retrograde transport between the ER and Golgi; involved in transcription elongation in response to osmostress through phosphorylation at Ser695 by Hog1p; inhibitor of gene silencing; cleaves ubiquitin fusions but not polyubiquitin; also has mRNA binding activity; protein abundance increases in response to DNA replication stress	protein deubiquitination|ribophagy|regulation of ER to Golgi vesicle-mediated transport|regulation of response to osmotic stress	ubiquitin-specific protease activity|mRNA binding	cytoplasm
YKR084C	YKR084C	HBS1	hom	Verified	0.60054400437575	0.274071871698136	no	1372	0.28150834629446	956	NA	FT	TRANSLATION|NUCLEOTIDE METABOLISM			GTPase with similarity to translation release factors; together with binding partner Dom34p, facilitates ribosomal subunit dissociation and peptidyl-tRNA release when translation is stalled; genetically implicated in mRNA no-go decay	nuclear-transcribed mRNA catabolic process, no-go decay|ribosome disassembly|nonfunctional rRNA decay	ribosome binding|GTPase activity	cytoplasm
YGL231C	YGL231C	EMC4	hom	Verified	0.600008962948319	0.27425013108321	no	1373	0.295442826013627	996	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm ZK616.6/EMC-4, fly CG11137, human TMM85	protein folding in endoplasmic reticulum	molecular_function	ER membrane protein complex|endoplasmic reticulum
YER115C	YER115C	SPR6	hom	Verified	0.599332109980643	0.274475719719112	no	1374	0.282577879393375	974	NA	FT	CELL CYCLE			Protein of unknown function, expressed during sporulation; not required for sporulation, but gene exhibits genetic interactions with other genes required for sporulation	ascospore formation	molecular_function	cellular_component
YPR042C	YPR042C	PUF2	hom	Verified	0.598944710504312	0.274604877458677	no	1375	0.293037273587269	994	NA					Member of the PUF protein family, which is defined by the presence of Pumilio homology domains that confer RNA binding activity; preferentially binds mRNAs encoding membrane-associated proteins	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	mRNA binding	cytoplasm
YOL046C_d	YOL046C	YOL046C	hom	Dubious	0.598700248557951	0.274686395710376	no	1376	0.246933101261603	855	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data;almost completely overlaps the verified gene PSK2/YOL045W	Unknown	Unknown	Unknown
YKR007W	YKR007W	MEH1	hom	Verified	0.598585139475294	0.274724784103539	no	1377	0.285907565423464	983	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS			Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; loss results in a defect in vacuolar acidification	microautophagy|vacuolar acidification	molecular_function	fungal-type vacuole membrane|EGO complex|late endosome membrane
YDR057W	YDR057W	YOS9	hom	Verified	0.598251207039003	0.27483616412766	no	1378	0.269904317668023	898	NA	FT	PROTEOLYSIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	UBIQUITIN LIGASE COMPLEX	ER quality-control lectin; integral subunit of the HRD ligase; binds to glycans with terminal alpha-1,6 linked mannose on misfolded N-glycosylated proteins and participates in targeting proteins to ERAD; member of the OS-9 protein family	ER-associated protein catabolic process	oligosaccharide binding	luminal surveillance complex|Hrd1p ubiquitin ligase ERAD-L complex|endoplasmic reticulum lumen
YIL098C	YIL098C	FMC1	hom	Verified	0.597704257471322	0.275018642083316	no	1379	0.288209552567199	988	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial matrix protein, required for assembly or stability at high temperature of the F1 sector of mitochondrial F1F0 ATP synthase; null mutant temperature sensitive growth on glycerol is suppressed by multicopy expression of Odc1p	mitochondrial proton-transporting ATP synthase complex assembly	molecular_function	mitochondrion|mitochondrial matrix
YDR132C	YDR132C	YDR132C	hom	Verified	0.597645716383935	0.275038176592982	no	1380	0.272043643741	898	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	NUCLEUS|PLASMA MEMBRANE		Protein of unknown function; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress; YDR132C has a paralog, YLR108C, that arose from the whole genome duplication	biological_process	molecular_function	nucleus|cytoplasm
YNL041C	YNL041C	COG6	hom	Verified	0.597531958186366	0.275076138392528	no	1381	0.384164486812902	1275	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments	intra-Golgi vesicle-mediated transport|CVT pathway	molecular_function	Golgi transport complex
YGL026C	YGL026C	TRP5	hom	Verified	0.596920547017188	0.275280214201183	no	1382	0.353470138875849	1171	NA	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Tryptophan synthase, catalyzes the last step of tryptophan biosynthesis; regulated by the general control system of amino acid biosynthesis	tryptophan biosynthetic process	tryptophan synthase activity	nucleus|cytoplasm
YMR316C-B_d	YMR316C-B	YMR316C-B	hom	Dubious	0.596008039722542	0.275584927916458	no	1383	0.231897370784653	825	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YBL088C	YBL088C	TEL1	hom	Verified	0.592227982506289	0.276848966881603	no	1384	0.27319623891457	948	NA	FT	CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION	NUCLEUS|MITOCHONDRION|CHROMOSOME		Protein kinase primarily involved in telomere length regulation; contributes to cell cycle checkpoint control in response to DNA damage; functionally redundant with Mec1p; regulates P-body formation induced by replication stress; homolog of human ataxia-telangiectasia mutated (ATM) gene, the gene responsible for ataxia telangiectasia (AT) (OMIM 607585)	double-strand break repair|histone phosphorylation|telomere maintenance|response to DNA damage stimulus|phosphorylation|DNA damage induced protein phosphorylation	protein kinase activity|telomeric DNA binding	mitochondrion|nucleus
YNL219C	YNL219C	ALG9	hom	Verified	0.592169868657545	0.276868422106747	no	1385	0.289494367534766	975	NA	FT	LIPID METABOLISM|CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Mannosyltransferase, involved in N-linked glycosylation; catalyzes both the transfer of seventh mannose residue on B-arm and ninth mannose residue on the C-arm from Dol-P-Man to lipid-linked oligosaccharides; mutation of the human ortholog causes type 1 congenital disorders of glycosylation	dolichol-linked oligosaccharide biosynthetic process|protein glycosylation	mannosyltransferase activity	integral to membrane|endoplasmic reticulum
YER178W	YER178W	PDA1	hom	Verified	0.59199918972811	0.276925565490124	no	1386	0.294943133397621	1020	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex, catalyzes the direct oxidative decarboxylation of pyruvate to acetyl-CoA; phosphorylated; regulated by glucose	acetyl-CoA biosynthetic process from pyruvate	pyruvate dehydrogenase (acetyl-transferring) activity	mitochondrial nucleoid|mitochondrion|mitochondrial pyruvate dehydrogenase complex
YML124C	YML124C	TUB3	hom	Verified	0.591588802138666	0.277062987073084	no	1387	0.340398226056878	1176	NA	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|NUCLEOTIDE METABOLISM|CHROMOSOME SEGREGATION	NUCLEUS|CYTOSKELETON		Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; expressed at lower level than Tub1p; TUB3 has a paralog, TUB1, that arose from the whole genome duplication	nuclear migration along microtubule|nuclear migration involved in conjugation with cellular fusion|homologous chromosome segregation|mitotic sister chromatid segregation	structural constituent of cytoskeleton	tubulin complex|cytoplasmic microtubule|kinetochore microtubule|nuclear microtubule|spindle pole body|polar microtubule
YBR288C	YBR288C	APM3	hom	Verified	0.591312112629816	0.277155657612256	no	1388	0.297086967557862	1029	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Mu3-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway	Golgi to vacuole transport|vesicle-mediated transport	molecular_function	AP-3 adaptor complex
YDL113C	YDL113C	ATG20	hom	Verified	0.590827057995984	0.277318151658848	no	1389	0.261836047119361	900	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS			Sorting nexin family member required for the cytoplasm-to-vacuole targeting (Cvt) pathway and for endosomal sorting; has a Phox homology domain that binds phosphatidylinositol-3-phosphate; interacts with Snx4p; potential Cdc28p substrate	mitochondrion degradation|early endosome to Golgi transport|macroautophagy|CVT pathway	phosphatidylinositol-3-phosphate binding	endosome|pre-autophagosomal structure|extrinsic to membrane
YDL136W	YDL136W	RPL35B	hom	Verified	0.588420304742403	0.27812510607979	no	1390	0.275779342721596	919	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L35B; homologous to mammalian ribosomal protein L35 and bacterial L29; RPL35B has a paralog, RPL35A, that arose from the whole genome duplication	cytoplasmic translation|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome	cytosolic large ribosomal subunit|preribosome, large subunit precursor
YLR048W	YLR048W	RPS0B	hom	Verified	0.587969745761676	0.278276300076505	no	1391	0.247782705539522	837	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; RPS0B has a paralog, RPS0A, that arose from the whole genome duplication; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2	cytoplasmic translation|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|rRNA export from nucleus|ribosomal small subunit assembly|endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome	cytosolic small ribosomal subunit
YPL206C	YPL206C	PGC1	hom	Verified	0.587921948629181	0.278292341702285	no	1392	0.253080153999253	871	NA	FT	LIPID METABOLISM|CARBOHYDRATE METABOLISM	MITOCHONDRION		Phosphatidyl Glycerol phospholipase C; regulates the phosphatidylglycerol (PG) content via a phospholipase C-type degradation mechanism; contains glycerophosphodiester phosphodiesterase motifs	glycerophospholipid catabolic process|phosphatidylglycerol catabolic process	phosphatidylglycerol phospholipase C activity	mitochondrion|lipid particle
YDL229W	YDL229W	SSB1	hom	Verified	0.586202335647334	0.278869776158727	no	1393	0.254248270801808	861	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RESPONSE TO NUTRIENT LEVELS			Cytoplasmic ATPase that is a ribosome-associated molecular chaperone; functions with J-protein partner Zuo1p; may be involved in folding of newly-made polypeptide chains; member of the HSP70 family; interacts with phosphatase subunit Reg1p; SSB1 has a paralog, SSB2, that arose from the whole genome duplication	cytoplasmic translation|cellular response to glucose starvation|translational termination|ribosomal subunit export from nucleus|regulation of translational fidelity|rRNA processing|'de novo' cotranslational protein folding	unfolded protein binding|ATPase activity|calmodulin binding	plasma membrane|polysome|cytoplasm
YKL081W	YKL081W	TEF4	hom	Verified	0.586036802348096	0.278925391871763	no	1394	0.288860406175035	978	NA	FT	TRANSLATION	MITOCHONDRION	RIBOSOME	Gamma subunit of translational elongation factor eEF1B, stimulates the binding of aminoacyl-tRNA (AA-tRNA) to ribosomes by releasing eEF1A (Tef1p/Tef2p) from the ribosomal complex	translational elongation	translation elongation factor activity	mitochondrion|ribosome|eukaryotic translation elongation factor 1 complex
YDR336W_p	YDR336W	YDR336W	hom	Uncharacterized	0.585587758469514	0.279076288354274	no	1395	0.289519780634137	988	NA					Putative protein of unknown function; sumoylated under stress conditions in a genome wide study; YDR336W is not an essential gene	biological_process	molecular_function	cellular_component
YGR097W	YGR097W	ASK10	hom	Verified	0.585525449426858	0.27909722978987	no	1396	0.28433990489787	997	NA	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO OXIDATIVE STRESS	NUCLEUS	RNA POL II, HOLOENZYME	Component of RNA polymerase II holoenzyme; phosphorylated in response to oxidative stress; has a role in destruction of Ssn8p; proposed to function in activation of the glycerol channel Fps1p; ASK10 has a paralog, RGC1, that arose from the whole genome duplication	cellular protein catabolic process|cellular response to oxidative stress|positive regulation of transcription from RNA polymerase II promoter|positive regulation of glycerol transport	molecular_function	DNA-directed RNA polymerase II, holoenzyme|cytoplasm
YPR121W	YPR121W	THI22	hom	Verified	0.584683904326281	0.279380139362033	no	1397	0.248073356992932	845	NA					Protein with similarity to hydroxymethylpyrimidine phosphate kinases; member of a gene family with THI20 and THI21; not required for thiamine biosynthesis	thiamine biosynthetic process	phosphomethylpyrimidine kinase activity|hydroxymethylpyrimidine kinase activity	cellular_component
YPL112C	YPL112C	PEX25	hom	Verified	0.583933813651462	0.279632421266047	no	1398	0.282096522008155	1000	NA	FT	PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION			Peripheral peroxisomal membrane peroxin required for the regulation of peroxisome size and maintenance, recruits GTPase Rho1p to peroxisomes, induced by oleate, interacts with homologous protein Pex27p	protein import into peroxisome matrix|peroxisome organization	molecular_function	peroxisomal membrane
YDR456W	YDR456W	NHX1	hom	Verified	0.58370380247856	0.279709804268552	no	1399	0.285321614410358	968	NA	FF|FT	ION HOMEOSTASIS|ION HOMEOSTASIS	GOLGI APPARATUS		Na+/H+ and K+/H+ exchanger, required for intracellular sequestration of Na+ and K+; located in the vacuole and late endosome compartments; required for osmotolerance to acute hypertonic shock and for vacuolar fusion	sodium ion transmembrane transport|potassium ion transmembrane transport|cellular monovalent inorganic cation homeostasis|vacuolar acidification	sodium:hydrogen antiporter activity|potassium:hydrogen antiporter activity	trans-Golgi network|late endosome|fungal-type vacuole membrane|integral to membrane|early endosome
YBR017C	YBR017C	KAP104	hom	Verified	0.582133449877615	0.280238397816569	no	1400	0.2623809219788	900	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE	SITE OF POLARIZED GROWTH		Transportin or cytosolic karyopherin beta 2; functions in the rg-nuclear localization signal-mediated nuclear import/reimport of mRNA-binding proteins Nab2p and Hrp1p; regulates asymmetric protein synthesis in daughter cells during mitosis	protein import into nucleus|cell cycle|mRNA-binding (hnRNP) protein import into nucleus|transcription factor import into nucleus	nuclear localization sequence binding	cytosol|integral to membrane|cellular bud neck|cellular bud tip
YLR028C	YLR028C	ADE16	hom	Verified	0.582055521503135	0.28026464174332	no	1401	0.274369414942296	908	NA	FT	OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY			Enzyme of 'de novo' purine biosynthesis; contains both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities; ADE16 has a paralog, ADE17, that arose from the whole genome duplication; ade16 ade17 mutants require adenine and histidine	ascospore formation|'de novo' IMP biosynthetic process|purine nucleotide biosynthetic process|aerobic respiration	phosphoribosylaminoimidazolecarboxamide formyltransferase activity|IMP cyclohydrolase activity	cytosol
YMR098C	YMR098C	ATP25	hom	Verified	0.581214694093257	0.280547882755055	no	1402	0.298939738837471	1016	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial protein required for the stability of Oli1p (Atp9p) mRNA and for the Oli1p ring formation; YMR098C is not an essential gene	mRNA stabilization|mitochondrial proton-transporting ATP synthase complex assembly	molecular_function	mitochondrion|mitochondrial inner membrane
YER181C_d	YER181C	YER181C	hom	Dubious	0.580874665940586	0.280662463918127	no	1403	0.273461392319295	940	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative data; extensively overlaps a Ty1 LTR; protein product is detected in highly purified mitochondria in high-throughput studies	Unknown	Unknown	Unknown
YHL024W	YHL024W	RIM4	hom	Verified	0.579956222722881	0.280972069905796	no	1404	0.300087801855378	1042	NA	FT	CELL CYCLE			Putative RNA-binding protein required for the expression of early and middle sporulation genes	meiosis|reciprocal meiotic recombination|sporulation resulting in formation of a cellular spore|premeiotic DNA replication	RNA binding	cytoplasm
YJR063W	YJR063W	RPA12	hom	Verified	0.579953697736828	0.280972921302691	no	1405	0.31139480436201	1081	NA	FF|FT		NUCLEUS		RNA polymerase I subunit A12.2; contains two zinc binding domains, and the N terminal domain is responsible for anchoring to the RNA pol I complex	termination of RNA polymerase I transcription|transcription of nuclear large rRNA transcript from RNA polymerase I promoter	molecular_function	DNA-directed RNA polymerase I complex
YMR153C-A_d	YMR153C-A	YMR153C-A	hom	Dubious	0.578866973584148	0.281339468155299	no	1406	0.235316765112517	828	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NUP53	Unknown	Unknown	Unknown
YPR012W_d	YPR012W	YPR012W	hom	Dubious	0.578843024978796	0.281347548503795	no	1407	0.277892548889585	947	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPR012W is not an essential gene	Unknown	Unknown	Unknown
YKL034W	YKL034W	TUL1	hom	Verified	0.578214694230311	0.281559589648055	no	1408	0.280179410967616	993	NA	FT	PROTEOLYSIS	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Subunit of the DSC ubiquitin ligase complex; golgi-localized RING-finger ubiquitin ligase (E3) involved in sorting polar transmembrane domain containing membrane proteins to multivesicular bodies for delivery to the vacuole; proposed involvement in the quality control of misfolded TMD containing proteins; ortholog of fission yeast dsc1	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|protein ubiquitination	ubiquitin-protein ligase activity	integral to membrane|Golgi apparatus
YER144C	YER144C	UBP5	hom	Verified	0.57725620661916	0.281883196368625	no	1409	0.283420398517761	974	NA	FT	PROTEOLYSIS	SITE OF POLARIZED GROWTH		Putative ubiquitin-specific protease, closest paralog of Doa4p but has no functional overlap; concentrates at the bud neck	protein deubiquitination	ubiquitin-specific protease activity	incipient cellular bud site|cellular bud neck
YIL066C	YIL066C	RNR3	hom	Verified	0.576853306392393	0.282019277916303	no	1410	0.278627678618887	974	NA	FT	OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM	MITOCHONDRION		Minor isoform of the large subunit of ribonucleotide-diphosphate reductase; the RNR complex catalyzes rate-limiting step in dNTP synthesis, regulated by DNA replication and DNA damage checkpoint pathways via localization of small subunits	deoxyribonucleotide biosynthetic process	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	mitochondrion|ribonucleoside-diphosphate reductase complex|cytoplasm
YOR054C	YOR054C	VHS3	hom	Verified	0.575334597706774	0.282532513509439	no	1411	0.292296097215144	993	NA	FT	CELL CYCLE|ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS|COFACTOR METABOLISM			Negative regulatory subunit of protein phosphatase 1 Ppz1p and also a subunit of the phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis	coenzyme A biosynthetic process|cellular monovalent inorganic cation homeostasis	phosphopantothenoylcysteine decarboxylase activity|protein phosphatase inhibitor activity	phosphopantothenoylcysteine decarboxylase complex
YGL230C_p	YGL230C	YGL230C	hom	Uncharacterized	0.573785578140943	0.2830564545836	no	1412	0.26578607356414	893	NA					Putative protein of unknown function; non-essential gene	biological_process	molecular_function	cellular_component
YJL094C	YJL094C	KHA1	hom	Verified	0.573672617875904	0.283094680550542	no	1413	0.268783083465621	906	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION|GOLGI APPARATUS		Putative K+/H+ antiporter with a probable role in intracellular cation homeostasis, localized to Golgi vesicles and detected in highly purified mitochondria in high-throughput studies	monovalent inorganic cation transport	potassium:hydrogen antiporter activity	mitochondrion|integral to membrane|Golgi apparatus
YNL226W_d	YNL226W	YNL226W	hom	Dubious	0.573302965138283	0.283219789050119	no	1414	0.28130512521339	953	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene JJJ1/YNL227C	Unknown	Unknown	Unknown
YDL025C	YDL025C	RTK1	hom	Verified	0.573249875272605	0.283237759425614	no	1415	0.322528193982452	1109	NA	FT	PROTEIN PHOSPHORYLATION			Putative protein kinase, potentially phosphorylated by Cdc28p; interacts with ribosome biogenesis factors, Cka2, Gus1 and Arc1; protein abundance increases in response to DNA replication stress	biological_process	protein serine/threonine kinase activity|protein kinase activity	cellular_component
YLR270W	YLR270W	DCS1	hom	Verified	0.573159281962294	0.283268425595681	no	1416	0.297270443907743	1020	NA	FT		NUCLEUS|MITOCHONDRION		Non-essential hydrolase involved in mRNA decapping; activates Xrn1p; may function in a feedback mechanism to regulate deadenylation, contains pyrophosphatase activity and a HIT (histidine triad) motif; interacts with neutral trehalase Nth1p; required for growth on glycerol medium; protein abundance increases in response to DNA replication stress	deadenylation-dependent decapping of nuclear-transcribed mRNA|positive regulation of nuclease activity|nuclear-transcribed mRNA catabolic process, deadenylation-independent decay	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|enzyme activator activity|m7G(5')pppN diphosphatase activity	mitochondrion|nucleus|cytoplasmic mRNA processing body|cytoplasm
YER001W	YER001W	MNN1	hom	Verified	0.573055667111415	0.283303501557438	no	1417	0.262236747121407	896	NA	FT	CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Alpha-1,3-mannosyltransferase, integral membrane glycoprotein of the Golgi complex, required for addition of alpha1,3-mannose linkages to N-linked and O-linked oligosaccharides, one of five S. cerevisiae proteins of the MNN1 family	N-glycan processing|protein O-linked glycosylation	alpha-1,3-mannosyltransferase activity	Golgi apparatus
YOL107W_p	YOL107W	YOL107W	hom	Uncharacterized	0.57271701976896	0.283418155839832	no	1418	0.273454946132591	944	NA	FT		ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and colocalizes in a punctate pattern with the early golgi/COPI vesicles; YOL107W is not an essential protein	biological_process	molecular_function	COPI-coated vesicle|Golgi apparatus
YCR006C_d	YCR006C	YCR006C	hom	Dubious	0.572164389246653	0.283605305182705	no	1419	0.289119996028624	976	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YGL151W	YGL151W	NUT1	hom	Verified	0.571490568336212	0.283833575946623	no	1420	0.281018206662761	958	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS|MITOCHONDRION		Component of the RNA polymerase II mediator complex, which is required for transcriptional activation and also has a role in basal transcription	regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	molecular_function	mitochondrion|mediator complex|nucleus
YBR048W	YBR048W	RPS11B	hom	Verified	0.571236107897539	0.283919802554797	no	1421	0.292630381541501	993	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S11 and bacterial S17; RPS11B has a paralog, RPS11A, that arose from the whole genome duplication	cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|ribosomal small subunit assembly	structural constituent of ribosome	cytosolic small ribosomal subunit|90S preribosome
YDL222C	YDL222C	FMP45	hom	Verified	0.569253725451176	0.284591982701399	no	1422	0.256791438311936	878	NA	FT	CELL WALL ORG/BIOGENESIS	MITOCHONDRION|PLASMA MEMBRANE		Integral membrane protein localized to mitochondria (untagged protein); required for sporulation and maintaining sphingolipid content; has sequence similarity to SUR7 and YNL194C	fungal-type cell wall organization|ascospore formation	molecular_function	cell cortex|mitochondrion|integral to membrane|plasma membrane
YBR118W	YBR118W	TEF2	hom	Verified	0.568599960200059	0.284813825922755	no	1423	0.26502734605498	893	NA	FT	TRANSLATION|NUCLEOTIDE METABOLISM|RNA LOCALIZATION	CYTOSKELETON	RIBOSOME	Translational elongation factor EF-1 alpha; also encoded by TEF1; functions in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomes; may also have a role in tRNA re-export from the nucleus; TEF2 has a paralog, TEF1, that arose from the whole genome duplication	translational elongation|tRNA export from nucleus	GDP binding|GTP binding|translation elongation factor activity	ribosome|eukaryotic translation elongation factor 1 complex|cytoplasm
YLR018C	YLR018C	POM34	hom	Verified	0.568173752751779	0.284958496003952	no	1424	0.228380667919132	778	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|CYTOSKELETON ORGANIZATION|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	Subunit of the transmembrane ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis and spindle pole body duplication	nuclear pore organization|protein import into nucleus|spindle pole body duplication associated with nuclear envelope	structural constituent of nuclear pore	nuclear pore transmembrane ring|integral to membrane|integral to nuclear outer membrane|nuclear pore
YPL227C	YPL227C	ALG5	hom	Verified	0.566481725193434	0.285533176272629	no	1425	0.292342809320633	1018	NA	FT	CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		UDP-glucose:dolichyl-phosphate glucosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulum	protein N-linked glycosylation	dolichyl-phosphate beta-glucosyltransferase activity	endoplasmic reticulum membrane
YHL017W_p	YHL017W	YHL017W	hom	Uncharacterized	0.56452558399959	0.286198246872105	no	1426	0.26772122346444	890	NA	FT		GOLGI APPARATUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein co-localizes with clathrin-coated vesicles; YHL017W has a paralog, PTM1, that arose from the whole genome duplication	biological_process	molecular_function	integral to membrane|clathrin-coated vesicle
YOR123C	YOR123C	LEO1	hom	Verified	0.564225754767759	0.286300251134592	no	1427	0.293698762327273	1003	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE	NUCLEUS	RNA POL II, HOLOENZYME	Component of the Paf1 complex; which associates with RNA polymerase II and is involved in histone methylation; plays a role in regulating Ty1 transposition; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay	chromatin organization|Unknown|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription-coupled nucleotide-excision repair|histone H3-K4 trimethylation|transcription elongation from RNA polymerase II promoter	RNA binding|RNA polymerase II transcription factor binding transcription factor activity	nucleus|Cdc73/Paf1 complex
YCL044C	YCL044C	MGR1	hom	Verified	0.564064214033987	0.286355215716732	no	1428	0.276604509216157	944	NA	FT	PROTEOLYSIS	MITOCHONDRION		Subunit of the mitochondrial (mt) i-AAA protease supercomplex, which degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr3p that binds to substrates to facilitate proteolysis; required for growth of cells lacking mtDNA	misfolded or incompletely synthesized protein catabolic process	misfolded protein binding	mitochondrion|i-AAA complex
YMR169C	YMR169C	ALD3	hom	Verified	0.563884149875779	0.286416488836805	no	1429	0.285509069912576	978	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS			Cytoplasmic aldehyde dehydrogenase, involved in beta-alanine synthesis; uses NAD+ as the preferred coenzyme; very similar to Ald2p; expression is induced by stress and repressed by glucose	beta-alanine biosynthetic process|polyamine catabolic process	aldehyde dehydrogenase (NAD) activity	cytoplasm
YLR318W	YLR318W	EST2	hom	Verified	0.562833503024716	0.286774132148554	no	1430	0.282671816856948	985	NA	FT		NUCLEUS|CHROMOSOME		Reverse transcriptase subunit of the telomerase holoenzyme, essential for telomerase core catalytic activity, involved in other aspects of telomerase assembly and function; mutations in human homolog are associated with aplastic anemia	telomere maintenance via telomerase|replicative cell aging	telomerase activity|telomeric template RNA reverse transcriptase activity|telomeric DNA binding	telomerase catalytic core complex|nucleolus|nucleus|telomerase holoenzyme complex
YOR246C	YOR246C	ENV9	hom	Verified	0.562658761206005	0.286833635308783	no	1431	0.295580087132652	1003	NA	FF|FT	OXIDATION-REDUCTION PROCESS|VACUOLAR PROTEIN PROCESSING			Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and defects in vacuolar morphology; has similarity to oxidoreductases, found in lipid particles; required for replication of Brome mosaic virus in S. cerevisiae, a model system for studying replication of positive-strand RNA viruses in their natural hosts	vacuole organization|vacuolar protein processing	oxidoreductase activity	lipid particle
YCR053W	YCR053W	THR4	hom	Verified	0.562039039886308	0.287044710242285	no	1432	0.264150997033669	892	NA	FT	VESICLE-MEDIATED TRANSPORT|KETONE METABOLISM|MEMBRANE ORGANIZATION|AMINO ACID METABOLISM	NUCLEUS		Threonine synthase, conserved protein that catalyzes formation of threonine from O-phosphohomoserine; expression is regulated by the GCN4-mediated general amino acid control pathway	endocytosis|threonine metabolic process	threonine synthase activity	nucleus|cytoplasm
YMR214W	YMR214W	SCJ1	hom	Verified	0.56133109458622	0.287285923933479	no	1433	0.298543452865707	1040	NA	FT	PROTEIN LOCALIZATION|PROTEOLYSIS	ENDOPLASMIC RETICULUM		One of several homologs of bacterial chaperone DnaJ, located in the ER lumen where it cooperates with Kar2p to mediate maturation of proteins	ER-associated protein catabolic process|protein folding in endoplasmic reticulum|response to unfolded protein	chaperone binding	endoplasmic reticulum lumen
YER060W-A	YER060W-A	FCY22	hom	Verified	0.560868128914609	0.287443719132181	no	1434	0.258932461677682	855	NA					Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function	transmembrane transport	nucleobase transmembrane transporter activity	integral to membrane
YDR371W_p	YDR371W	CTS2	hom	Uncharacterized	0.559892260065385	0.287776464208417	no	1435	0.27563647687949	913	NA	FT	CARBOHYDRATE METABOLISM			Putative chitinase, functionally complements A. gossypii cts2 mutant sporulation defect	sporulation resulting in formation of a cellular spore	molecular_function	cytoplasm
YCL039W	YCL039W	GID7	hom	Verified	0.558165712529681	0.288365615921033	no	1436	0.284194152640994	957	NA	FT	KETONE METABOLISM|CARBOHYDRATE METABOLISM|PROTEOLYSIS	NUCLEUS		Subunit of GID Complex that binds directly to central component Vid30p; GID complex is involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; Gid7p contains six WD40 repeats; computational analysis suggests that Gid7p and Moh1p have similar functions	negative regulation of gluconeogenesis|proteasomal ubiquitin-dependent protein catabolic process	molecular_function	nucleus|GID complex|cytoplasm
YJR040W	YJR040W	GEF1	hom	Verified	0.557221171951761	0.288688162998355	no	1437	0.290386992935638	1027	NA	FF|FT	ION HOMEOSTASIS|ION HOMEOSTASIS	ENDOPLASMIC RETICULUM|GOLGI APPARATUS|PLASMA MEMBRANE		Voltage-gated chloride channel localized to the golgi, the endosomal system, and plasma membrane, and involved in cation homeostasis; highly homologous to vertebrate voltage-gated chloride channels; modulates TBSV model (+) RNA virus replication by regulating copper metabolism	cellular copper ion homeostasis|cellular iron ion homeostasis	voltage-gated chloride channel activity	endosome|integral to membrane|endoplasmic reticulum|Golgi apparatus|plasma membrane|fungal-type vacuole|Golgi medial cisterna
YNL148C	YNL148C	ALF1	hom	Verified	0.55635569909632	0.288983858665996	no	1438	0.327119314473707	1089	NA	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS	NUCLEUS|CYTOSKELETON		Alpha-tubulin folding protein, similar to mammalian cofactor B; Alf1p-GFP localizes to cytoplasmic microtubules; required for the folding of alpha-tubulin and may play an additional role in microtubule maintenance	protein folding|post-chaperonin tubulin folding pathway	microtubule binding|alpha-tubulin binding	nucleus|cytoplasm
YIL014C-A_p	YIL014C-A	YIL014C-A	hom	Uncharacterized	0.556210470640972	0.289033491077973	no	1439	0.298312722709939	1023	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YFL041W	YFL041W	FET5	hom	Verified	0.555858331305128	0.289153852765633	no	1440	0.266807229472979	919	NA	FT	ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS	PLASMA MEMBRANE		Multicopper oxidase, integral membrane protein with similarity to Fet3p; may have a role in iron transport	iron ion transport	ferroxidase activity	fungal-type vacuole membrane|integral to membrane
YAL036C	YAL036C	RBG1	hom	Verified	0.554588872305835	0.289587951019655	no	1441	0.291944316264734	1003	NA	FT	TRANSLATION		RIBOSOME	Member of the DRG family of GTP-binding proteins; associates with translating ribosomes; interacts with Tma46p, Ygr250cp, Gir2p and Yap1p via two-hybrid	cytoplasmic translation	GTP binding	polysomal ribosome|polysome|cytoplasm
YGL217C_d	YGL217C	YGL217C	hom	Dubious	0.553064312313885	0.290109686423414	no	1442	0.27262589411129	921	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF KIP3/YGL216W	Unknown	Unknown	Unknown
YBR191W	YBR191W	RPL21A	hom	Verified	0.552432572011721	0.290326009806174	no	1443	0.300439076797831	1021	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L21A; homologous to mammalian ribosomal protein L21, no bacterial homolog; RPL21A has a paralog, RPL21B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YCR003W	YCR003W	MRPL32	hom	Verified	0.551534817692168	0.290633552798028	no	1444	0.31028940475046	1040	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial inner membrane|mitochondrial large ribosomal subunit
YOR346W	YOR346W	REV1	hom	Verified	0.549633759700865	0.291285299296362	no	1445	0.267084421827666	879	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS|MITOCHONDRION|CHROMOSOME		Deoxycytidyl transferase; involved in repair of abasic sites and adducted guanines in damaged DNA by translesion synthesis (TLS); forms a complex with the subunits of DNA polymerase zeta, Rev3p and Rev7p; relocalizes from nucleus to cytoplasm upon DNA replication stress	error-prone translesion synthesis|error-free translesion synthesis	deoxycytidyl transferase activity|DNA-directed DNA polymerase activity	nuclear chromatin|mitochondrion|replication fork
YPL133C	YPL133C	RDS2	hom	Verified	0.544810179361717	0.2929420384529	no	1446	0.264832169273349	921	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|SIGNALING|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Transcription factor involved in regulating gluconeogenesis and glyoxylate cycle genes; member of the zinc cluster family of proteins; confers resistance to ketoconazole	positive regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source|positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter|cellular response to xenobiotic stimulus|positive regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus|cytoplasm
YIL014W	YIL014W	MNT3	hom	Verified	0.544361810079399	0.293096260232214	no	1447	0.268832074640731	944	NA	FT	CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Alpha-1,3-mannosyltransferase, adds the fourth and fifth alpha-1,3-linked mannose residues to O-linked glycans during protein O-glycosylation	protein O-linked glycosylation	alpha-1,3-mannosyltransferase activity	cellular_component
YIL050W	YIL050W	PCL7	hom	Verified	0.544022235484993	0.29321308587911	no	1448	0.236304390845841	806	NA	FT	CELL CYCLE|OXIDATION-REDUCTION PROCESS|CELL DIVISION|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS		Pho85p cyclin of the Pho80p subfamily, forms a functional kinase complex with Pho85p which phosphorylates Mmr1p and is regulated by Pho81p; involved in glycogen metabolism, expression is cell-cycle regulated	regulation of glycogen catabolic process|regulation of cyclin-dependent protein kinase activity|regulation of protein stability|regulation of glycogen biosynthetic process	cyclin-dependent protein kinase regulator activity	cyclin-dependent protein kinase holoenzyme complex|nucleus
YGL004C	YGL004C	RPN14	hom	Verified	0.541809911867865	0.293974731241814	no	1449	0.311943774106066	1041	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS	NUCLEUS		Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasome regulatory particle (RP); null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; interacts with Rpt5p	proteasome regulatory particle assembly|ubiquitin-dependent protein catabolic process	molecular_function	cytosol|nucleus|cytoplasm
YGL228W	YGL228W	SHE10	hom	Verified	0.541480336922568	0.294088273549552	no	1450	0.29072807179558	1013	NA	FT		MITOCHONDRION		Putative glycosylphosphatidylinositol (GPI)-anchored protein of unknown function; overexpression causes growth arrest	biological_process	molecular_function	cellular_component
YML006C	YML006C	GIS4	hom	Verified	0.540655205961822	0.294372629384579	no	1451	0.300213118254621	991	NA	FT	SIGNALING|ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		CAAX box containing protein of unknown function, proposed to be involved in the RAS/cAMP signaling pathway	cellular ion homeostasis|intracellular signal transduction	molecular_function	plasma membrane
YPL207W	YPL207W	TYW1	hom	Verified	0.537086717948376	0.295603857469006	no	1452	0.292501343579856	1010	NA	FT	RNA PROCESSING|OXIDATION-REDUCTION PROCESS	ENDOPLASMIC RETICULUM		Iron-sulfer protein required for synthesis of Wybutosine modified tRNA; Wybutosine is a modified guanosine found at the 3'-position adjacent to the anticodon of phenylalanine tRNA which supports reading frame maintenance by stabilizing codon-anticodon interactions; induction by Yap5p in response to iron provides protection from high iron toxicity; overexpression results in increased cellular iron	wybutosine biosynthetic process	molecular_function	endoplasmic reticulum
YDL167C	YDL167C	NRP1	hom	Verified	0.536264130369338	0.295888008571389	no	1453	0.304911057592739	1034	NA					Putative RNA binding protein of unknown function; localizes to stress granules induced by glucose deprivation; predicted to be involved in ribosome biogenesis	biological_process	molecular_function	cytoplasmic stress granule|cytoplasm
YMR279C	YMR279C	YMR279C	hom	Verified	0.536099838489856	0.295944775874167	no	1454	0.307210168629237	1030	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Putative boron transporter involved in boron efflux and resistance; overexpression mutant but not null mutant displays boron tolerance phenotype; identified as a heat-induced gene in a high-throughout screen; YMR279C is not an essential gene; YMR279C has a paralog, ATR1, that arose from the whole genome duplication	borate transmembrane transport	borate efflux transmembrane transporter activity	integral to membrane
YDR346C	YDR346C	SVF1	hom	Verified	0.535181908220002	0.2962620376734	no	1455	0.32165324509168	1096	NA	FT	RESPONSE TO OXIDATIVE STRESS	NUCLEUS		Protein with a potential role in cell survival pathways, required for the diauxic growth shift; expression in mammalian cells increases survival under conditions inducing apoptosis; mutant has increased aneuploidy tolerance	cellular response to oxidative stress	molecular_function	nucleus|cytoplasm
YJL045W	YJL045W	YJL045W	hom	Verified	0.534645168981112	0.296447621671453	no	1456	0.286302131607187	983	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Minor succinate dehydrogenase isozyme; homologous to Sdh1p, the major isozyme reponsible for the oxidation of succinate and transfer of electrons to ubiquinone; induced during the diauxic shift in a Cat8p-dependent manner	cellular respiration	succinate dehydrogenase (ubiquinone) activity	mitochondrion
YMR042W	YMR042W	ARG80	hom	Verified	0.532711565314837	0.297116629512813	no	1457	0.294821944612229	994	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Transcription factor involved in regulation of arginine-responsive genes; acts with Arg81p and Arg82p	Unknown|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity|core promoter proximal region sequence-specific DNA binding	nucleus
YEL041W	YEL041W	YEF1	hom	Verified	0.531659502264688	0.297480922712721	no	1458	0.320215188710827	1047	NA	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM			ATP-NADH kinase; phosphorylates both NAD and NADH; homooctameric structure consisting of 60-kDa subunits; similar to Pos5p; overexpression complements certain pos5 phenotypes; YEF1 has a paralog, UTR1, that arose from the whole genome duplication	NADP biosynthetic process	NAD+ kinase activity|NADH kinase activity	cellular_component
YJR152W	YJR152W	DAL5	hom	Verified	0.531549867623906	0.297518897144526	no	1459	0.292079426265649	983	NA	FT		PLASMA MEMBRANE		Allantoate permease; ureidosuccinate permease; also transports dipeptides, though with lower affinity than for allantoate and ureidosuccinate; expression is constitutive but sensitive to nitrogen catabolite repression	dipeptide transport|allantoate transport	dipeptide transporter activity|allantoate transmembrane transporter activity	integral to membrane|plasma membrane
YGR146C-A_p	YGR146C-A	YGR146C-A	hom	Uncharacterized	0.530898019947179	0.297744724981313	no	1460	0.292905115986373	993	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YER017C	YER017C	AFG3	hom	Verified	0.530595719725387	0.297849481205827	no	1461	0.320288390820987	1075	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Component, with Yta12p, of the mitochondrial inner membrane m-AAA protease; mediates degradation of misfolded or unassembled proteins and is also required for correct assembly of mitochondrial enzyme complexes; involved in cytoplasmic mRNA translation and aging	proteolysis|signal peptide processing|protein complex assembly|protein import into mitochondrial intermembrane space	metallopeptidase activity|protein binding|ATPase activity	mitochondrion|mitochondrial inner boundary membrane|mitochondrial inner membrane|m-AAA complex
YML050W	YML050W	AIM32	hom	Verified	0.53046434706888	0.297895011066943	no	1462	0.315474984038145	1072	NA					Putative protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss	biological_process	molecular_function	cellular_component
YMR075W	YMR075W	RCO1	hom	Verified	0.530237524365407	0.297973628547849	no	1463	0.304721161340018	1053	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION	NUCLEUS|CHROMOSOME		Essential subunit of the histone deacetylase Rpd3S complex; interacts with Eaf3p	regulation of DNA-dependent DNA replication initiation|negative regulation of antisense RNA transcription|transcription elongation from RNA polymerase II promoter|histone deacetylation	molecular_function	Rpd3S complex|histone deacetylase complex|nucleus|Rpd3L complex
YLR360W	YLR360W	VPS38	hom	Verified	0.528595319989431	0.298543103763164	no	1464	0.285208894160522	978	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEOLYSIS|VACUOLAR TRANSPORT	GOLGI APPARATUS		Part of a Vps34p phosphatidylinositol 3-kinase complex that functions in carboxypeptidase Y (CPY) sorting; binds Vps30p and Vps34p to promote production of phosphatidylinositol 3-phosphate (PtdIns3P) which stimulates kinase activity; required for overflow degradation of misfolded proteins when ERAD is saturated	ER-associated protein catabolic process|late endosome to vacuole transport	molecular_function	phosphatidylinositol 3-kinase complex II
YNL270C	YNL270C	ALP1	hom	Verified	0.528252665813886	0.298661990019764	no	1465	0.289117147334794	1015	NA	FT		PLASMA MEMBRANE		Arginine transporter; expression is normally very low and it is unclear what conditions would induce significant expression; ALP1 has a paralog, CAN1, that arose from the whole genome duplication	basic amino acid transport	basic amino acid transmembrane transporter activity	integral to membrane|plasma membrane
YNR008W	YNR008W	LRO1	hom	Verified	0.528146782864333	0.298698731200854	no	1466	0.303277886499053	1039	NA	FT	LIPID METABOLISM	ENDOPLASMIC RETICULUM		Acyltransferase that catalyzes diacylglycerol esterification; one of several acyltransferases that contribute to triglyceride synthesis; putative homolog of human lecithin cholesterol acyltransferase	lipid storage|triglyceride biosynthetic process	phospholipid:diacylglycerol acyltransferase activity	lipid particle|perinuclear endoplasmic reticulum
YNL054W	YNL054W	VAC7	hom	Verified	0.527109474135459	0.299058783966104	no	1467	0.242226697509661	841	NA	FT	LIPID METABOLISM			Integral vacuolar membrane protein involved in vacuole inheritance and morphology; activates Fab1p kinase activity under basal conditions and also after hyperosmotic shock	positive regulation of phosphatidylinositol biosynthetic process|positive regulation of kinase activity	molecular_function	fungal-type vacuole membrane|integral to membrane|PAS complex|vacuolar membrane|cytoplasm
YHL033C	YHL033C	RPL8A	hom	Verified	0.526477002659693	0.299278413242731	no	1468	0.280448923022419	953	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L8A; mutation results in decreased amounts of free 60S subunits; homologous to mammalian ribosomal protein L7A, no bacterial homolog; RPL8A has a paralog, RPL8B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YLR181C	YLR181C	VTA1	hom	Verified	0.526468256510179	0.299281450905215	no	1469	0.293453432590933	1017	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|VACUOLAR TRANSPORT			Multivesicular body (MVB) protein involved in endosomal protein sorting; regulates Vps4p activity by promoting its oligomerization; has an N-terminal Vps60- and Did2- binding domain, a linker region, and a C-terminal Vps4p binding domain	late endosome to vacuole transport via multivesicular body sorting pathway|positive regulation of protein oligomerization|late endosome to vacuole transport	ATPase activator activity	endosome|endosome membrane|multivesicular body
YMR193W	YMR193W	MRPL24	hom	Verified	0.523470719077228	0.300323361158076	no	1470	0.279784073269173	961	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit; two mitochondrial ribosomal proteins, YmL14 and YmL24, have been assigned to the same gene	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YMR058W	YMR058W	FET3	hom	Verified	0.523002992349524	0.300486085443282	no	1471	0.315263035720027	1084	NA	FT	ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS	PLASMA MEMBRANE		Ferro-O2-oxidoreductase; required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity, belongs to class of integral membrane multicopper oxidases; protein abundance increases in response to DNA replication stress	iron assimilation by reduction and transport|high-affinity iron ion transport|response to copper ion	ferroxidase activity|iron ion transmembrane transporter activity	integral to membrane|high affinity iron permease complex|plasma membrane
YML096W_p	YML096W	YML096W	hom	Uncharacterized	0.522090807321211	0.300803553327691	no	1472	0.307820631062685	1047	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Putative protein of unknown function with similarity to asparagine synthetases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YML096W is not an essential gene and partially overlaps the verified gene RAD10	biological_process	molecular_function	cytoplasm
YPL106C	YPL106C	SSE1	hom	Verified	0.519364105761653	0.301753428555444	no	1473	0.322179541648258	1072	NA					ATPase component of the heat shock protein Hsp90 chaperone complex; binds unfolded proteins; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasm; SSE1 has a paralog, SSE2, that arose from the whole genome duplication	protein folding|protein refolding	peptide binding|adenyl-nucleotide exchange factor activity|ATP binding	polysome|cytoplasm
YGL032C	YGL032C	AGA2	hom	Verified	0.519347870752445	0.301759088228452	no	1474	0.297797434376747	991	NA					Adhesion subunit of a-agglutinin of a-cells, C-terminal sequence acts as a ligand for alpha-agglutinin (Sag1p) during agglutination, modified with O-linked oligomannosyl chains, linked to anchorage subunit Aga1p via two disulfide bonds	agglutination involved in conjugation with cellular fusion	cell adhesion molecule binding	fungal-type cell wall
YPL216W_p	YPL216W	YPL216W	hom	Uncharacterized	0.517944493390602	0.302248498670628	no	1475	0.303456969635264	1039	NA	FT	CHROMATIN ORGANIZATION	NUCLEUS		Putative protein of unknown function; YPL216W is not an essential gene	biological_process	molecular_function	cellular_component
YDR073W	YDR073W	SNF11	hom	Verified	0.517220432157538	0.302501145255087	no	1476	0.28317787642699	958	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS	RSC COMPLEX	Subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; interacts with a highly conserved 40-residue sequence of Snf2p; relocates to the cytosol under hypoxic conditions	positive regulation of transcription from RNA polymerase II promoter	molecular_function	SWI/SNF complex
YKR058W	YKR058W	GLG1	hom	Verified	0.516893337408212	0.302615309417611	no	1477	0.293051242399516	1020	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY			Glycogenin glucosyltransferase; self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; similar to mammalian glycogenin; GLG1 has a paralog, GLG2, that arose from the whole genome duplication	glycogen biosynthetic process	glycogenin glucosyltransferase activity	cellular_component
YER119C	YER119C	AVT6	hom	Verified	0.516891230451899	0.302616044860089	no	1478	0.293697537444368	1015	NA	FT	VACUOLAR TRANSPORT			Vacuolar aspartate and glutamate exporter; member of a family of seven genes (AVT1-7) related to vesicular GABA-glycine transporters; involved in compartmentalizing acidic amino acids in response to nitrogen starvation; AVT6 has a paralog, AVT5, that arose from the whole genome duplication	amino acid export from vacuole|transmembrane transport	L-aspartate transmembrane transporter activity|transporter activity|L-glutamate transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane|fungal-type vacuole
YOR343C_d	YOR343C	YOR343C	hom	Dubious	0.515882045441298	0.302968397404023	no	1479	0.287134905526341	985	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YHR168W	YHR168W	MTG2	hom	Verified	0.515119869237859	0.303234629534071	no	1480	0.295735884776532	1006	NA	FT	TRANSLATION|NUCLEOTIDE METABOLISM	MITOCHONDRION		Putative GTPase, member of the Obg family; peripheral protein of the mitochondrial inner membrane that associates with the large ribosomal subunit; required for mitochondrial translation, possibly via a role in ribosome assembly	cytoplasmic translation	ribosome binding|GTPase activity	mitochondrial inner membrane|extrinsic to membrane
YKR045C_p	YKR045C	YKR045C	hom	Uncharacterized	0.513828499704948	0.303685950228115	no	1481	0.304580319376144	1015	NA					Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm	biological_process	molecular_function	cytoplasm
YLR441C	YLR441C	RPS1A	hom	Verified	0.513560118642592	0.303779784333615	no	1482	0.324059427804188	1100	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Ribosomal protein 10 (rp10) of the small (40S) subunit; homologous to mammalian ribosomal protein S3A, no bacterial homolog; RPS1A has a paralog, RPS1B, that arose from the whole genome duplication	cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome	cytosolic small ribosomal subunit|90S preribosome
YMR088C	YMR088C	VBA1	hom	Verified	0.512761032279205	0.304059245568471	no	1483	0.302831062422996	1023	NA					Permease of basic amino acids in the vacuolar membrane	basic amino acid transport	basic amino acid transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane
YLR265C	YLR265C	NEJ1	hom	Verified	0.512379183646451	0.304192828391844	no	1484	0.291507187137168	978	NA	FT	RESPONSE TO DNA DAMAGE	ENDOMEMBRANE SYSTEM|NUCLEUS		Protein involved in regulation of nonhomologous end joining; interacts with DNA ligase IV components Dnl4p and Lif1p; repressed by MAT heterozygosity; regulates cellular distribution of Lif1p	double-strand break repair via nonhomologous end joining|double-strand break repair via single-strand annealing	DNA end binding	DNA ligase IV complex|nucleus
YNR007C	YNR007C	ATG3	hom	Verified	0.512247202300444	0.304239005752869	no	1485	0.312047397635258	1062	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS			E2-like enzyme involved in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; plays a role in formation of Atg8p-phosphatidylethanolamine conjugates, which are involved in membrane dynamics during autophagy and Cvt; interaction with Atg8p is regulated by its acetylation by Esa1p (catalytic subunit of NuA4 histone acetyltransferase complex) while attenuation of Atg3 acetylation is mediated by histone deacetylase Rpd3p	C-terminal protein lipidation|piecemeal microautophagy of nucleus|mitochondrion degradation|CVT pathway|autophagic vacuole assembly	Atg8 ligase activity	cytosol|cytoplasm
YNR056C	YNR056C	BIO5	hom	Verified	0.511967955078865	0.30433671848475	no	1486	0.2957892936729	1005	NA	FT	KETONE METABOLISM|COFACTOR METABOLISM	PLASMA MEMBRANE		Putative transmembrane protein involved in the biotin biosynthesis pathway; responsible for uptake of 7-keto 8-aminopelargonic acid; BIO5 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis	biotin biosynthetic process|vitamin transport	transmembrane transporter activity	integral to membrane|plasma membrane
YGR200C	YGR200C	ELP2	hom	Verified	0.511497945276736	0.304501213407327	no	1487	0.31982095324017	1078	NA	FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|RNA PROCESSING	NUCLEUS		Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; target of Kluyveromyces lactis zymocin	regulation of transcription from RNA polymerase II promoter|protein urmylation|tRNA wobble uridine modification	molecular_function	Elongator holoenzyme complex|nucleus|cytoplasm
YLR077W	YLR077W	FMP25	hom	Verified	0.510752677518278	0.304762124698466	no	1488	0.311848726959768	1058	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial inner membrane protein required for an early step in assembly of respiratory complex III (cytochrome bc1 complex); mRNA is targeted to mitochondria	mitochondrial respiratory chain complex III assembly	molecular_function	mitochondrion|integral to mitochondrial inner membrane
YDR108W	YDR108W	TRS85	hom	Verified	0.510187074304671	0.304960203414252	no	1489	0.339405521424311	1138	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS|PEROXISOME ORGANIZATION	GOLGI APPARATUS		Subunit of TRAPPIII (transport protein particle), a multimeric guanine nucleotide-exchange factor for Ypt1p, required for membrane expansion during autophagy and the CVT pathway; directs Ypt1p to the PAS; late post-replication meiotic role	meiosis|vesicle organization|piecemeal microautophagy of nucleus|ER to Golgi vesicle-mediated transport|peroxisome degradation|macroautophagy|protein localization to pre-autophagosomal structure|CVT pathway	molecular_function	TRAPP complex|pre-autophagosomal structure
YNR001C	YNR001C	CIT1	hom	Verified	0.509942996733678	0.305045698969005	no	1490	0.316202600144156	1085	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Citrate synthase; catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate; the rate-limiting enzyme of the TCA cycle; nuclear encoded mitochondrial protein; CIT1 has a paralog, CIT2, that arose from the whole genome duplication	glutamate biosynthetic process|tricarboxylic acid cycle|acetyl-CoA catabolic process|citrate metabolic process	citrate (Si)-synthase activity	mitochondrion
YLR264W	YLR264W	RPS28B	hom	Verified	0.507378306653546	0.305944701957036	no	1491	0.291143638751363	992	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S28, no bacterial homolog; RPS28B has a paralog, RPS28A, that arose from the whole genome duplication	cytoplasmic translation|rRNA export from nucleus	structural constituent of ribosome	cytosolic small ribosomal subunit
YNL191W	YNL191W	DUG3	hom	Verified	0.507307090033743	0.305969682303525	no	1492	0.297044696220425	1008	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Component of glutamine amidotransferase (GATase II); forms a complex with Dug2p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p)	glutathione catabolic process	peptidase activity|omega peptidase activity|gamma-glutamyltransferase activity|carbon-nitrogen ligase activity, with glutamine as amido-N-donor	cytoplasm
YGL162W	YGL162W	SUT1	hom	Verified	0.504822150845913	0.306841878192413	no	1493	0.302542977618502	1030	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Transcription factor of the Zn2Cys6 family involved in sterol uptake; involved in induction of hypoxic gene expression; relocalizes from nucleus to cytoplasm upon DNA replication stress	positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II repressing transcription factor binding	nucleus
YIL008W	YIL008W	URM1	hom	Verified	0.504000988649802	0.307130341120584	no	1494	0.313426852341416	1052	NA	FT	RNA PROCESSING|CELL DIVISION|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		Ubiquitin-like protein involved in thiolation of cytoplasmic tRNAs; receives sulfur from the E1-like enzyme Uba4p and transfers it to tRNA; also functions as a protein tag with roles in nutrient sensing and oxidative stress response	cellular response to oxidative stress|tRNA wobble position uridine thiolation|cell budding|protein urmylation|invasive growth in response to glucose limitation|tRNA wobble uridine modification	protein tag	cytosol|nucleus|cytoplasm
YKL077W_p	YKL077W	YKL077W	hom	Uncharacterized	0.503642104244942	0.307256449757354	no	1495	0.316255383927826	1059	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole	biological_process	molecular_function	fungal-type vacuole
YDL142C	YDL142C	CRD1	hom	Verified	0.50295303768296	0.307498645221338	no	1496	0.303778500406914	1029	NA	FT	LIPID METABOLISM|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS	MITOCHONDRION		Cardiolipin synthase; produces cardiolipin, which is a phospholipid of the mitochondrial inner membrane that is required for normal mitochondrial membrane potential and function; also required for normal vacuolar ion homeostasis	lipid biosynthetic process|cellular ion homeostasis|mitochondrial membrane organization	cardiolipin synthase activity	mitochondrion|integral to membrane
YLR043C	YLR043C	TRX1	hom	Verified	0.502904742037439	0.307515623488676	no	1497	0.304815098780378	1044	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|RESPONSE TO OXIDATIVE STRESS	ENDOMEMBRANE SYSTEM|NUCLEUS|GOLGI APPARATUS		Cytoplasmic thioredoxin isoenzyme; part of the thioredoxin system which protects cells against oxidative and reductive stress; forms LMA1 complex with Pbi2p; acts as a cofactor for Tsa1p, required for ER-Golgi transport and vacuole inheritance; protein abundance increases in response to DNA replication stress	vacuole inheritance|regulation of DNA replication|cell redox homeostasis|protein deglutathionylation|retrograde vesicle-mediated transport, Golgi to ER|cellular response to oxidative stress|ER to Golgi vesicle-mediated transport|vacuole fusion, non-autophagic	disulfide oxidoreductase activity	cytosol|fungal-type vacuole
YER046W-A_d	YER046W-A	YER046W-A	hom	Dubious	0.502588600426396	0.307626772817884	no	1498	0.299688108796847	1058	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YPR072W	YPR072W	NOT5	hom	Verified	0.502400344665772	0.307692968324541	no	1499	0.310816553931185	1028	NA	FT	TRANSCRIPTION FROM RNA POL II|RNA PROCESSING	NUCLEUS		Subunit of the CCR4-NOT complex, which is a global transcriptional regulator with roles in transcription initiation and elongation and in mRNA degradation	deadenylation-independent decapping of nuclear-transcribed mRNA|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|nuclear-transcribed mRNA poly(A) tail shortening|transcription elongation from RNA polymerase II promoter|protein ubiquitination	ubiquitin-protein ligase activity	CCR4-NOT core complex|cytoplasm
YHR161C	YHR161C	YAP1801	hom	Verified	0.500459520924739	0.308375775931216	no	1500	0.30971986689834	1061	NA	FT	VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON		Protein of the AP180 family, involved in clathrin cage assembly; binds Pan1p and clathrin; YAP1801 has a paralog, YAP1802, that arose from the whole genome duplication	endocytosis	clathrin binding	actin cortical patch
YKL211C	YKL211C	TRP3	hom	Verified	0.500302298080266	0.308431118098089	no	1501	0.465210423775727	1525	NA	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM			Indole-3-glycerol-phosphate synthase; forms bifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p	tryptophan biosynthetic process	indole-3-glycerol-phosphate synthase activity|anthranilate synthase activity	anthranilate synthase complex|cytoplasm
YMR285C	YMR285C	NGL2	hom	Verified	0.500137403398905	0.308489165415288	no	1502	0.286714131571994	969	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Protein involved in 5.8S rRNA processing; Ccr4p-like RNase required for correct 3'-end formation of 5.8S rRNA at site E; similar to Ngl1p; NGL2 has a paralog, NGL3, that arose from the whole genome duplication	rRNA processing	endoribonuclease activity	intracellular
YCR095W-A_p	YCR095W-A	YCR095W-A	hom	Uncharacterized	0.499850364602403	0.308590222131742	no	1503	0.305008757224249	1012	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YDL090C	YDL090C	RAM1	hom	Verified	0.499787545278614	0.308612340639266	no	1504	0.357776353217657	1201	NA	FF|FT	PROTEIN PRENYLATION			Beta subunit of the CAAX farnesyltransferase (FTase) that prenylates the a-factor mating pheromone and Ras proteins; required for the membrane localization of Ras proteins and a-factor; homolog of the mammalian FTase beta subunit	protein farnesylation	protein farnesyltransferase activity	protein farnesyltransferase complex
YCR020C	YCR020C	PET18	hom	Verified	0.499215199423457	0.308813893986443	no	1505	0.317132953641752	1074	NA					Protein of unknown function, has weak similarity to proteins involved in thiamin metabolism; expression is induced in the absence of thiamin	thiamine metabolic process	molecular_function	cytosol
YPL029W	YPL029W	SUV3	hom	Verified	0.498307605423335	0.309133624058471	no	1506	0.352886702370159	1193	NA	FF|FT	RNA PROCESSING|MITOCHONDRION ORGANIZATION	MITOCHONDRION|CHROMOSOME		ATP-dependent RNA helicase, component of the mitochondrial degradosome along with the RNase Dss1p; the degradosome associates with the ribosome and mediates RNA turnover; also required during splicing of the COX1 AI5_beta intron	mitochondrial DNA replication|mitochondrial RNA catabolic process|Group I intron splicing	exoribonuclease II activity|ATP-dependent RNA helicase activity	mitochondrion|mitochondrial chromosome|mitochondrial degradosome
YNL168C_p	YNL168C	FMP41	hom	Uncharacterized	0.49774873531829	0.309330576542869	no	1507	0.295850756925575	1016	NA	FT		MITOCHONDRION		Putative protein of unknown function; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YPR006C	YPR006C	ICL2	hom	Verified	0.497306704011636	0.309486392454042	no	1508	0.313861885583425	1101	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		2-methylisocitrate lyase of the mitochondrial matrix, functions in the methylcitrate cycle to catalyze the conversion of 2-methylisocitrate to succinate and pyruvate; ICL2 transcription is repressed by glucose and induced by ethanol	threonine catabolic process|propionate metabolic process	methylisocitrate lyase activity	mitochondrion|mitochondrial matrix
YLL013C	YLL013C	PUF3	hom	Verified	0.496140389797103	0.309897682261817	no	1509	0.310572409118631	1052	NA	FT	OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY|RNA LOCALIZATION	MITOCHONDRION		Protein of the mitochondrial outer surface, links the Arp2/3 complex with the mitochore during anterograde mitochondrial movement; also binds to and promotes degradation of mRNAs for select nuclear-encoded mitochondrial proteins	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|nuclear-transcribed mRNA catabolic process|intracellular mRNA localization|mitochondrion organization|aerobic respiration|mitochondrion localization	mRNA binding	external side of mitochondrial outer membrane|cytoplasm
YDR519W	YDR519W	FPR2	hom	Verified	0.496055121338267	0.309927760730622	no	1510	0.332431180304575	1126	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Membrane-bound peptidyl-prolyl cis-trans isomerase (PPIase); binds to the drugs FK506 and rapamycin; expression pattern suggests possible involvement in ER protein trafficking; relocalizes from nucleus to vacuole upon DNA replication stress	biological_process	FK506 binding|peptidyl-prolyl cis-trans isomerase activity	endoplasmic reticulum membrane
YGR279C	YGR279C	SCW4	hom	Verified	0.495743708100975	0.310037622629957	no	1511	0.31697999337613	1062	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM			Cell wall protein with similarity to glucanases; scw4 scw10 double mutants exhibit defects in mating	conjugation with cellular fusion	glucosidase activity	extracellular region|fungal-type cell wall
YKR059W	YKR059W	TIF1	hom	Verified	0.495587181510071	0.310092849259428	no	1512	0.309645306227078	1047	NA	FT	TRANSLATION		RIBOSOME	Translation initiation factor eIF4A; DEA(D/H)-box RNA helicase that couples ATPase activity to RNA binding and unwinding; forms a dumbbell structure of two compact domains connected by a linker; interacts with eIF4G; protein abundance increases in response to DNA replication stress; TIF1 has a paralog, TIF2, that arose from the whole genome duplication	translational initiation	ATP-dependent RNA helicase activity|translation initiation factor activity	ribosome|eukaryotic translation initiation factor 4F complex
YOR031W	YOR031W	CRS5	hom	Verified	0.495312495861134	0.31018977581592	no	1513	0.303538280838859	1024	NA					Copper-binding metallothionein, required for wild-type copper resistance	response to metal ion	copper ion binding	cytoplasm
YDR401W_d	YDR401W	YDR401W	hom	Dubious	0.494888431358025	0.310339438621412	no	1514	0.325668732457484	1101	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YGL105W	YGL105W	ARC1	hom	Verified	0.494421386345507	0.310504306655432	no	1515	0.322362082513565	1103	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION			Protein that binds tRNA and methionyl- and glutamyl-tRNA synthetases (Mes1p and Gus1p), delivering tRNA to them, stimulating catalysis, and ensuring their localization to the cytoplasm; also binds quadruplex nucleic acids; protein abundance increases in response to DNA replication stress	positive regulation of ligase activity|tRNA aminoacylation for protein translation	enzyme activator activity|tRNA binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding	methionyl glutamyl tRNA synthetase complex|cytoplasm
YNR074C	YNR074C	AIF1	hom	Verified	0.49434782144996	0.310530278715504	no	1516	0.314916964162729	1088	NA	FT	OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS	NUCLEUS|MITOCHONDRION|PLASMA MEMBRANE		Mitochondrial cell death effector that translocates to the nucleus in response to apoptotic stimuli, homolog of mammalian Apoptosis-Inducing Factor, putative reductase	response to singlet oxygen|positive regulation of apoptotic process	oxidoreductase activity, acting on a sulfur group of donors, NAD or NADP as acceptor	mitochondrion|nucleus|plasma membrane
YDL063C	YDL063C	SYO1	hom	Verified	0.493242825304526	0.310920510797152	no	1517	0.324755178195098	1083	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS	NUCLEUS		Transport adaptor or symportin; facilitates synchronized nuclear coimport of the two 5S-rRNA binding proteins Rpl5p and Rpl11p; required for biogenesis of the large ribosomal subunit; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus	ribosomal large subunit biogenesis	molecular_function	nucleus|cytoplasm
YKL117W	YKL117W	SBA1	hom	Verified	0.492088662952346	0.311328333195179	no	1518	0.296636492995879	959	NA	FT		NUCLEUS		Co-chaperone that binds to and regulates Hsp90 family chaperones; important for pp60v-src activity in yeast; homologous to the mammalian p23 proteins, and like p23 can regulate telomerase activity; protein abundance increases in response to DNA replication stress	protein folding|positive regulation of telomere maintenance via telomerase|regulation of telomerase activity	chaperone binding	nucleus|cytoplasm
YHR112C	YHR112C	YHR112C	hom	Verified	0.49149640782779	0.311537696072696	no	1519	0.306427712489739	1067	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Protein of unknown function; localizes to the cytoplasm and nucleus; overexpression affects protein trafficking through the endocytic pathway	sulfur compound metabolic process	cystathionine beta-lyase activity	nucleus|cytoplasm
YDR161W_p	YDR161W	YDR161W	hom	Uncharacterized	0.491227040914723	0.311632937759421	no	1520	0.315727480760972	1070	NA	FT	PROTEOLYSIS	NUCLEUS		Putative protein of unknown function; non-essential gene; proposed function in rRNA and ribosome biosynthesis based on transcriptional co-regulation; genetic interactions suggest a role in ER-associated protein degradation (ERAD)	ER-associated protein catabolic process	molecular_function	nucleus|cytoplasm
YHR087W	YHR087W	RTC3	hom	Verified	0.491143458400669	0.311662493096165	no	1521	0.332425512380244	1142	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Protein of unknown function involved in RNA metabolism; has structural similarity to SBDS, the human protein mutated in Shwachman-Diamond Syndrome (the yeast SBDS ortholog = SDO1); null mutation suppresses cdc13-1 temperature sensitivity; protein abundance increases in response to DNA replication stress	RNA metabolic process	molecular_function	nucleus|cytoplasm
YKR036C	YKR036C	CAF4	hom	Verified	0.490824860387456	0.311775162612866	no	1522	0.296957955355638	980	NA	FT	TRANSCRIPTION FROM RNA POL II|MITOCHONDRION ORGANIZATION|PEROXISOME ORGANIZATION	NUCLEUS|MITOCHONDRION		WD40 repeat-containing protein associated with the CCR4-NOT complex; interacts in a Ccr4p-dependent manner with Ssn2p; also interacts with Fis1p, Mdv1p and Dnm1p and plays a role in mitochondrial fission; CAF4 has a paralog, MDV1, that arose from the whole genome duplication	peroxisome fission|mitochondrial fission|regulation of transcription from RNA polymerase II promoter	molecular_function	mitochondrion|CCR4-NOT complex
YBR179C	YBR179C	FZO1	hom	Verified	0.490672343119526	0.311829105303204	no	1523	0.318252844180268	1056	NA	FT	MEMBRANE ORGANIZATION|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitofusin; integral membrane protein involved in mitochondrial outer membrane tethering and fusion; role in mitochondrial genome maintenance; efficient tethering and degradation of Fzo1p requires an intact N-terminal GTPase domain; targeted for destruction by the ubiquitin ligase SCF-Mdm30p and the cytosolic ubiquitin-proteasome system	mitochondrial fusion	GTPase activity|protein homodimerization activity	mitochondrial outer membrane|mitochondrion|mitochondrial inner membrane|integral to mitochondrial outer membrane
YOR263C_d	YOR263C	YOR263C	hom	Dubious	0.489779695269536	0.312144900162966	no	1524	0.312267744858084	1090	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF DES3/YOR264W	Unknown	Unknown	Unknown
YGR143W	YGR143W	SKN1	hom	Verified	0.489490667291141	0.312247180112117	no	1525	0.331466531343376	1109	NA	FT	LIPID METABOLISM|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM			Protein involved in sphingolipid biosynthesis; type II membrane protein with similarity to Kre6p	fungal-type cell wall organization|(1->6)-beta-D-glucan biosynthetic process|sphingolipid biosynthetic process	glucosidase activity	integral to membrane
YOR366W_d	YOR366W	YOR366W	hom	Dubious	0.488127493412589	0.312729769055969	no	1526	0.321889504549034	1091	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR365C	Unknown	Unknown	Unknown
YER153C	YER153C	PET122	hom	Verified	0.487566658223412	0.312928408462602	no	1527	0.312027190076977	1038	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet494p; located in the mitochondrial inner membrane	positive regulation of mitochondrial translation|mitochondrial respiratory chain complex IV biogenesis	translation initiation factor activity	mitochondrion|mitochondrial inner membrane|integral to mitochondrial inner membrane
YDL198C	YDL198C	GGC1	hom	Verified	0.486868546268946	0.31317574513099	no	1528	0.321285402315247	1091	NA	FT	ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS	MITOCHONDRION		Mitochondrial GTP/GDP transporter, essential for mitochondrial genome maintenance; has a role in mitochondrial iron transport; member of the mitochondrial carrier family	cellular iron ion homeostasis|mitochondrial genome maintenance|transmembrane transport|guanine nucleotide transport	guanine nucleotide transmembrane transporter activity	mitochondrion|integral to membrane|mitochondrial inner membrane
YNL063W	YNL063W	MTQ1	hom	Verified	0.486647505815892	0.313254075901461	no	1529	0.322919775683147	1101	NA	FT	TRANSLATION	MITOCHONDRION		S-adenosylmethionine-dependent methyltransferase; methylates translational release factor Mrf1p; similar to E.coli PrmC; is not an essential gene	translational readthrough	S-adenosylmethionine-dependent methyltransferase activity	mitochondrion
YCL069W	YCL069W	VBA3	hom	Verified	0.486604682258166	0.313269252388948	no	1530	0.314745548848362	1062	NA					Permease of basic amino acids in the vacuolar membrane	basic amino acid transport|transmembrane transport	basic amino acid transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane
YGR036C	YGR036C	CAX4	hom	Verified	0.486321159858307	0.31336973950385	no	1531	0.324628654944467	1062	NA	FT	LIPID METABOLISM|CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Dolichyl pyrophosphate (Dol-P-P) phosphatase with a luminally oriented active site in the ER, cleaves the anhydride linkage in Dol-P-P, required for Dol-P-P-linked oligosaccharide intermediate synthesis and protein N-glycosylation	lipid biosynthetic process|protein N-linked glycosylation	dolichyldiphosphatase activity	integral to endoplasmic reticulum membrane|integral to membrane
YOR138C	YOR138C	RUP1	hom	Verified	0.485483209111198	0.31366681024687	no	1532	0.326745975481914	1097	NA	FT		NUCLEUS		Protein that regulates Rsp5p, which is a HECT ubiquitin ligase; has a WW domain consensus motif of PPPSY (residues 131-135) that mediates binding of Rsp5p to Ubp2p; contains an UBA domain; relative distribution to the nucleus increases upon DNA replication stress	protein deubiquitination	protein binding	nucleus|cytoplasm
YGR221C	YGR221C	TOS2	hom	Verified	0.483736946903399	0.314286284294121	no	1533	0.306320957316402	1041	NA	FT	CELL DIVISION	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Protein involved in localization of Cdc24p to the site of bud growth; may act as a membrane anchor; localizes to the bud neck and bud tip; potentially phosphorylated by Cdc28p	budding cell bud growth	molecular_function	cellular bud neck|cellular bud tip
YEL051W	YEL051W	VMA8	hom	Verified	0.482763447438774	0.314631853640045	no	1534	0.339827854753948	1136	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Subunit D of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; plays a role in the coupling of proton transport and ATP hydrolysis	vacuolar acidification	proton-transporting ATPase activity, rotational mechanism	fungal-type vacuole membrane|vacuolar proton-transporting V-type ATPase, V1 domain|integral to membrane
YDL180W_p	YDL180W	YDL180W	hom	Uncharacterized	0.482475369138101	0.314734145800593	no	1535	0.321056561822974	1097	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole	biological_process	molecular_function	integral to membrane|fungal-type vacuole
YCR092C	YCR092C	MSH3	hom	Verified	0.48235998230542	0.314775121873366	no	1536	0.317401333894602	1087	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Mismatch repair protein, forms dimers with Msh2p that mediate repair of insertion or deletion mutations and removal of nonhomologous DNA ends, contains a PCNA (Pol30p) binding motif required for genome stability	mismatch repair|mitotic recombination|meiotic mismatch repair|removal of nonhomologous ends|DNA recombination	DNA insertion or deletion binding|mismatched DNA binding|double-strand/single-strand DNA junction binding|loop DNA binding|Y-form DNA binding	MutSbeta complex|nucleus|cytoplasm
YIR043C	YIR043C	YIR043C	hom	pseudogene	0.481978728513592	0.314910528607202	no	1537	0.315653743979975	1068	NA					Possible pseudogene in strain S288C; YIR043C and the adjacent ORF, YIR044C, together may encode a non-functional member of the conserved, often subtelomerically-encoded Cos protein family	biological_process	molecular_function	cellular_component
YDR084C	YDR084C	TVP23	hom	Verified	0.481923499693744	0.314930145830974	no	1538	0.28176255192952	970	NA	FT	VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern	vesicle-mediated transport	molecular_function	integral to membrane|integral to Golgi membrane|cytoplasm
YLR271W_p	YLR271W	YLR271W	hom	Uncharacterized	0.480785544144132	0.315334462696554	no	1539	0.295149718856465	992	NA	FT		NUCLEUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS	biological_process	molecular_function	nucleus|cytoplasm
YPL200W	YPL200W	CSM4	hom	Verified	0.47875036558564	0.316058115356953	no	1540	0.323473412543046	1080	NA	FT	CELL CYCLE|CHROMOSOME SEGREGATION	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|CHROMOSOME		Protein required for accurate chromosome segregation during meiosis; involved in meiotic telomere clustering (bouquet formation) and telomere-led rapid prophase movements	meiotic telomere clustering|meiotic chromosome segregation|synapsis|regulation of reciprocal meiotic recombination	molecular_function	nuclear chromosome, telomeric region|endoplasmic reticulum membrane
YCR073W-A	YCR073W-A	SOL2	hom	Verified	0.477422779749819	0.316530548119556	no	1541	0.325597770678018	1128	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|RNA LOCALIZATION|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS			Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol3p and Sol4p; SOL2 has a paralog, SOL1, that arose from the whole genome duplication	tRNA export from nucleus	molecular_function|6-phosphogluconolactonase activity	cytosol|cytoplasm
YFR040W	YFR040W	SAP155	hom	Verified	0.476403645962395	0.316893418845706	no	1542	0.324823278571817	1097	NA	FT	CELL CYCLE			Protein required for function of the Sit4p protein phosphatase; forms a complex with Sit4p; member of a family of similar proteins including Sap4p, Sap185p, and Sap190p; protein abundance increases in response to DNA replication stress	G1/S transition of mitotic cell cycle	protein serine/threonine phosphatase activity	cytoplasm
YLR356W	YLR356W	ATG33	hom	Verified	0.474939577259937	0.317415020549964	no	1543	0.310276190106223	1047	NA	FT		MITOCHONDRION		Mitochondrial mitophagy-specific protein; required primarily for mitophagy induced at the post-log phase; not required for other types of selective autophagy or macroautophagy; conserved within fungi, but not in higher eukaryotes	mitochondrion degradation	molecular_function	mitochondrion|integral to membrane
YPL213W	YPL213W	LEA1	hom	Verified	0.474711520426841	0.317496302719862	no	1544	0.319283762089624	1111	NA	FT	RNA PROCESSING	NUCLEUS		Component of U2 snRNP; disruption causes reduced U2 snRNP levels; physically interacts with Msl1p; putative homolog of human U2A' snRNP protein	mRNA splicing, via spliceosome	molecular_function	U2 snRNP|U2-type prespliceosome|cytoplasm
YJR116W_p	YJR116W	TDA4	hom	Uncharacterized	0.474277643565678	0.317650965892152	no	1545	0.270795725957675	916	NA					Putative protein of unknown function; null mutant is sensitive to expression of the top1-T722A allele	biological_process	molecular_function	integral to membrane
YNL059C	YNL059C	ARP5	hom	Verified	0.473602584757344	0.317891665964822	no	1546	0.333558647153903	1137	NA	FT	CHROMATIN ORGANIZATION	NUCLEUS|CHROMOSOME		Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes	nucleosome mobilization|chromatin remodeling	ATP-dependent 3'-5' DNA helicase activity	nucleus|Ino80 complex
YDR096W	YDR096W	GIS1	hom	Verified	0.473253208073257	0.318016270517058	no	1547	0.31208456526252	1039	NA	FT	TRANSCRIPTION FROM RNA POL II|LIPID METABOLISM|CHROMATIN ORGANIZATION|RESPONSE TO NUTRIENT LEVELS	NUCLEUS|MITOCHONDRION		Histone demethylase and transcription factor; regulates genes during nutrient limitation; negatively regulates DPP1, PHR1; activity modulated by limited proteasome-mediated proteolysis; has JmjC and JmjN domain in N-terminal region that interact, promoting stability and proper transcriptional activity; contains two transactivating domains downstream of Jmj domains and a C-terminal DNA binding domain; GIS1 has a paralog, RPH1, that arose from the whole genome duplication	negative regulation of transcription from RNA polymerase II promoter|chronological cell aging|regulation of phospholipid biosynthetic process|histone demethylation|positive regulation of transcription from RNA polymerase II promoter|maintenance of stationary phase in response to starvation	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|histone demethylase activity (H3-K36 specific)	mitochondrion|nucleus
YDR129C	YDR129C	SAC6	hom	Verified	0.472995045372346	0.318108357008046	no	1548	0.405823762620714	1342	NA	FF|FT	VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CELL DIVISION|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Fimbrin, actin-bundling protein; cooperates with Scp1p (calponin/transgelin) in the organization and maintenance of the actin cytoskeleton; relocalizes from plasma membrane to cytoplasm upon DNA replication stress	bipolar cellular bud site selection|actin filament organization|endocytosis|response to osmotic stress	actin filament binding|protein binding, bridging	actin filament bundle|mating projection tip|actin cortical patch
YLR190W	YLR190W	MMR1	hom	Verified	0.472769045838092	0.318188980146754	no	1549	0.283775868974257	957	NA	FT	CELL CYCLE|CELL DIVISION|MITOCHONDRION ORGANIZATION	MITOCHONDRION|SITE OF POLARIZED GROWTH		Phosphorylated protein of the mitochondrial outer membrane, localizes only to mitochondria of the bud; interacts with Myo2p to mediate mitochondrial distribution to buds; mRNA is targeted to the bud via the transport system involving She2p	mitochondrion inheritance	molecular_function	mitochondrial outer membrane|incipient cellular bud site|mitochondrion|cellular bud|cellular bud neck
YHR120W	YHR120W	MSH1	hom	Verified	0.472346995866864	0.318339565437826	no	1550	0.298734345331869	1049	NA	FT	RESPONSE TO DNA DAMAGE|MITOCHONDRION ORGANIZATION	MITOCHONDRION		DNA-binding protein of the mitochondria involved in repair of mitochondrial DNA, has ATPase activity and binds to DNA mismatches; has homology to E. coli MutS; transcription is induced during meiosis	DNA repair|mismatch repair|mitochondrial DNA repair|mitochondrion organization|reciprocal meiotic recombination|mitochondrial genome maintenance	guanine/thymine mispair binding|dinucleotide insertion or deletion binding|DNA-dependent ATPase activity	mitochondrion
YOR187W	YOR187W	TUF1	hom	Verified	0.472071344250412	0.318437932746837	no	1551	0.393877665982561	1283	NA	FT	TRANSLATION|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial translation elongation factor Tu; comprises both GTPase and guanine nucleotide exchange factor activities, while these activities are found in separate proteins in S. pombe and humans	mitochondrial translational elongation|mitochondrial translation	GTPase activity|translation elongation factor activity	mitochondrion|mitochondrial matrix
YPL229W_p	YPL229W	YPL229W	hom	Uncharacterized	0.471842551713758	0.318519587940331	no	1552	0.319300069125274	1093	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; not an essential gene; YPL229W has a paralog, YMR181C, that arose from the whole genome duplication	biological_process	molecular_function	cytoplasm
YBR072C-A_p	YBR072C-A	YBR072C-A	hom	Uncharacterized	0.471536940576697	0.318628673154193	no	1553	0.315977827729806	1040	NA					Putative protein of unknown function; identified by fungal homology and RT-PCR	biological_process	molecular_function	cellular_component
YGR149W_p	YGR149W	YGR149W	hom	Uncharacterized	0.470750013986408	0.318909632034385	no	1554	0.301609202823116	1035	NA					Putative protein of unknown function; predicted to be an integal membrane protein	biological_process	molecular_function	integral to membrane
YJR079W_p	YJR079W	YJR079W	hom	Uncharacterized	0.470476895113415	0.319007168867792	no	1555	0.338260811948662	1141	NA					Putative protein of unknown function; mutation results in impaired mitochondrial respiration	biological_process	molecular_function	cellular_component
YEL010W_d	YEL010W	YEL010W	hom	Dubious	0.470343727933422	0.319054730379991	no	1556	0.279443810978203	970	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YKR034W	YKR034W	DAL80	hom	Verified	0.469919626217215	0.319206220875526	no	1557	0.315361769212919	1079	NA	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Negative regulator of genes in multiple nitrogen degradation pathways; expression is regulated by nitrogen levels and by Gln3p; member of the GATA-binding family, forms homodimers and heterodimers with Gzf3p; DAL80 has a paralog, GZF3, that arose from the whole genome duplication	nitrogen catabolite repression of transcription|negative regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity	nucleus
YFR049W	YFR049W	YMR31	hom	Verified	0.469597654740981	0.319321250285178	no	1558	0.342251350239804	1145	NA	FT	TRANSLATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the small subunit, has similarity to human mitochondrial ribosomal protein MRP-S36	cytoplasmic translation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YBR246W	YBR246W	RRT2	hom	Verified	0.468785788998432	0.319611379384572	no	1559	0.335144038150822	1115	NA	FT	VESICLE-MEDIATED TRANSPORT			Protein required for last step of diphthamide biosynthesis; deletion leads to resistance to sordarin and accumulation of diphthine; WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rtt10p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription	peptidyl-diphthamide biosynthetic process from peptidyl-histidine|endocytic recycling	molecular_function	endosome|cytoplasm
YIL060W_p	YIL060W	YIL060W	hom	Uncharacterized	0.467316142590305	0.320136854405554	no	1560	0.329037697978437	1143	NA					Putative protein of unknown function; mutant accumulates less glycogen than does wild type; null mutation results in a decrease in plasma membrane electron transport; YIL060W is not an essential gene	biological_process	molecular_function	cellular_component
YDL160C-A	YDL160C-A	MHF2	hom	Verified	0.467228399795327	0.320168238446993	no	1561	0.329117069496705	1113	NA	FT	RESPONSE TO DNA DAMAGE			Component of the heterotetrameric MHF histone-fold complex; in humans the MMF complex interacts with both DNA and Mph1p ortholog FANCM to stabilize and remodel blocked replication forks and repair damaged DNA; mhf2 srs2 double mutants are MMS hypersensitive; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-X, also known as MHF2	response to DNA damage stimulus	molecular_function	cellular_component
YLR120C	YLR120C	YPS1	hom	Verified	0.466395249920273	0.320466305464528	no	1562	0.335751727201879	1135	NA	FT	CELL WALL ORG/BIOGENESIS|PROTEOLYSIS	PLASMA MEMBRANE		Aspartic protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor	fungal-type cell wall organization|protein processing	aspartic-type endopeptidase activity	fungal-type cell wall
YOL119C	YOL119C	MCH4	hom	Verified	0.465980363512697	0.320614778103466	no	1563	0.29746637174302	977	NA					Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport	transport	monocarboxylic acid transmembrane transporter activity|transporter activity	fungal-type vacuole membrane|integral to membrane
YLR366W_d	YLR366W	YLR366W	hom	Dubious	0.465754952139838	0.320695456608594	no	1564	0.316193294162934	1059	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR364C-A	Unknown	Unknown	Unknown
YFR008W	YFR008W	FAR7	hom	Verified	0.46484930117892	0.321019689605775	no	1565	0.325348181267259	1115	NA	FT	CELL CYCLE|SIGNALING			Protein involved in recovery from pheromone-induced cell cycle arrest; acts in a Far1p-independent pathway; interacts with Far3p, Far8p, Far9p, Far10p, and Far11p; protein abundance increases in response to DNA replication stress	re-entry into mitotic cell cycle after pheromone arrest	molecular_function	cellular_component
YGR275W	YGR275W	RTT102	hom	Verified	0.464799976080568	0.321037352455359	no	1566	0.334978690315364	1093	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|CHROMOSOME SEGREGATION	NUCLEUS	RSC COMPLEX	Component of both the SWI/SNF and RSC chromatin remodeling complexes; suggested role in chromosome maintenance; possible weak regulator of Ty1 transposition; protein abundance increases in response to DNA replication stress	chromosome segregation|nucleosome disassembly|chromatin remodeling|transcription elongation from RNA polymerase II promoter	molecular_function	RSC complex|SWI/SNF complex|nucleus
YKL055C	YKL055C	OAR1	hom	Verified	0.463285904599106	0.32157972391313	no	1567	0.33984202740535	1159	NA	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Mitochondrial 3-oxoacyl-[acyl-carrier-protein] reductase, may comprise a type II mitochondrial fatty acid synthase along with Mct1p	fatty acid metabolic process|aerobic respiration	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity	mitochondrion
YMR054W	YMR054W	STV1	hom	Verified	0.463238294673722	0.321596784941779	no	1568	0.325043407765474	1083	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Subunit a of the vacuolar-ATPase V0 domain, one of two isoforms (Stv1p and Vph1p); Stv1p is located in V-ATPase complexes of the Golgi and endosomes while Vph1p is located in V-ATPase complexes of the vacuole	vacuolar acidification	proton-transporting ATPase activity, rotational mechanism	vacuolar proton-transporting V-type ATPase, V0 domain|late endosome|integral to membrane|Golgi apparatus
YBR058C	YBR058C	UBP14	hom	Verified	0.463169735033264	0.321621353967119	no	1569	0.306693420443598	1054	NA	FT	KETONE METABOLISM|CARBOHYDRATE METABOLISM|PROTEOLYSIS	NUCLEUS		Ubiquitin-specific protease that specifically disassembles unanchored ubiquitin chains; involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; similar to human isopeptidase T	protein deubiquitination|negative regulation of gluconeogenesis|proteasomal ubiquitin-dependent protein catabolic process	ubiquitin-specific protease activity	cytoplasm
YER182W_p	YER182W	FMP10	hom	Uncharacterized	0.461638085398213	0.322170439006527	no	1570	0.319429398564425	1087	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YBR255W	YBR255W	MTC4	hom	Verified	0.46157120622208	0.32219442355219	no	1571	0.340605987967771	1131	NA					Protein of unknown function, required for normal growth rate at 15 degrees C; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; mtc4 is synthetically sick with cdc13-1	biological_process	molecular_function	cytoplasm
YKR106W	YKR106W	GEX2	hom	Verified	0.461092374433407	0.322366166232645	no	1572	0.307904759428658	1023	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Proton:glutathione antiporter localized to the vacuolar and plasma membranes; expressed at a very low level; almost identical to paralog Gex1p; potential role in resistance to oxidative stress and modulation of the PKA pathway	glutathione transmembrane transport	solute:hydrogen antiporter activity	integral to membrane|plasma membrane|vacuolar membrane
YOR072W_d	YOR072W	YOR072W	hom	Dubious	0.457945026197992	0.323495968566363	no	1573	0.366349451796551	1231	NA	FF				Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOR072W-A; diploid deletion strains are methotrexate, paraquat and wortmannin sensitive	Unknown	Unknown	Unknown
YJL181W_p	YJL181W	YJL181W	hom	Uncharacterized	0.457616610407194	0.323613953895207	no	1574	0.283425847921334	954	NA					Putative protein of unknown function; expression is cell-cycle regulated as shown by microarray analysis; potential regulatory target of Mbp1p, which binds to the YJL181W promoter region; YJL181W has a paralog, YJR030C, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YPR128C	YPR128C	ANT1	hom	Verified	0.457279034775656	0.323735248433257	no	1575	0.324090447483636	1122	NA	FT	KETONE METABOLISM|LIPID METABOLISM|ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|PEROXISOME ORGANIZATION			Peroxisomal adenine nucleotide transporter; involved in beta-oxidation of medium-chain fatty acid; required for peroxisome proliferation	ATP transport|fatty acid beta-oxidation|peroxisome organization	adenine nucleotide transmembrane transporter activity	integral to membrane|cytoplasm|integral to peroxisomal membrane
YPL155C	YPL155C	KIP2	hom	Verified	0.457251567499393	0.32374511854358	no	1576	0.284828546266219	989	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION	MITOCHONDRION|CYTOSKELETON		Kinesin-related motor protein involved in mitotic spindle positioning, stabilizes microtubules by targeting Bik1p to the plus end; Kip2p levels are controlled during the cell cycle	nuclear migration along microtubule|mitotic anaphase B|negative regulation of microtubule depolymerization	microtubule motor activity	mitochondrion|kinesin complex|cytoplasmic microtubule
YOR351C	YOR351C	MEK1	hom	Verified	0.457100550231211	0.323799387408951	no	1577	0.318353525147149	1083	NA	FT	CELL CYCLE|PROTEIN PHOSPHORYLATION	NUCLEUS		Meiosis-specific serine/threonine protein kinase, functions in meiotic checkpoint, promotes recombination between homologous chromosomes by suppressing double strand break repair between sister chromatids	meiosis|meiotic recombination checkpoint|protein phosphorylation	protein serine/threonine kinase activity|protein kinase activity	nucleus
YKL110C	YKL110C	KTI12	hom	Verified	0.456366628447693	0.324063179464445	no	1578	0.341770161345975	1158	NA	FT	TRANSCRIPTION FROM RNA POL II|RNA PROCESSING	NUCLEUS		Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p	regulation of transcription from RNA polymerase II promoter|cell growth|tRNA wobble uridine modification	chromatin binding	nucleus|cytoplasm
YBR111W-A	YBR111W-A	SUS1	hom	Verified	0.455952932884537	0.324211912194472	no	1579	0.389406916286028	1292	NA	FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE|HISTONE ACETYLTRANSFERASE	Component of both the SAGA histone acetylase and TREX-2 complexes; interacts with RNA polymerase II; involved in mRNA export coupled transcription activation and elongation; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP	poly(A)+ mRNA export from nucleus|regulation of protein localization|nuclear retention of pre-mRNA at the site of transcription|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|histone deubiquitination|histone H3-K4 methylation|transcription elongation from RNA polymerase II promoter|histone H3-K79 methylation|positive regulation of transcription from RNA polymerase II promoter	enzyme activator activity	DUBm complex|nucleoplasm|transcription export complex 2|SAGA complex|nuclear pore
YPL002C	YPL002C	SNF8	hom	Verified	0.455655496634214	0.324318864462333	no	1580	0.332239605196002	1134	NA	FF|FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|PROTEOLYSIS|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS			Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; appears to be functionally related to SNF7; involved in glucose derepression	negative regulation of transcription from RNA polymerase II promoter by glucose|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|protein targeting to vacuole	molecular_function	ESCRT II complex
YMR095C	YMR095C	SNO1	hom	Verified	0.45529014725067	0.324450256804762	no	1581	0.29982592057434	1023	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Protein of unconfirmed function, involved in pyridoxine metabolism; expression is induced during stationary phase; forms a putative glutamine amidotransferase complex with Snz1p, with Sno1p serving as the glutaminase	pyridoxine metabolic process|thiamine biosynthetic process|anti-apoptosis	molecular_function	cytoplasm
YIR018W	YIR018W	YAP5	hom	Verified	0.454283267835994	0.324812478737221	no	1582	0.315253387929452	1083	NA	FT	TRANSCRIPTION FROM RNA POL II|GENE SILENCING	NUCLEUS|CHROMOSOME		Basic leucine zipper (bZIP) iron-sensing transcription factor; YAP5 has a paralog, YAP7, that arose from the whole genome duplication	negative regulation of chromatin silencing at telomere|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter in response to iron|positive regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding RNA polymerase II transcription factor activity	nuclear chromatin|nucleus
YDR382W	YDR382W	RPP2B	hom	Verified	0.45156153003462	0.325792444587663	no	1583	0.312522298657383	1040	NA	FT	TRANSLATION		RIBOSOME	Ribosomal protein P2 beta, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm	translational elongation|cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YCL074W	YCL074W	YCL074W	hom	pseudogene	0.451399288472626	0.325850898027317	no	1584	0.323556106778094	1089	NA	FT		NUCLEUS		Pseudogene: encodes fragment of Ty Pol protein	transposition, RNA-mediated	ribonuclease activity|peptidase activity|RNA binding|RNA-directed DNA polymerase activity|DNA-directed DNA polymerase activity	retrotransposon nucleocapsid
YPL069C	YPL069C	BTS1	hom	Verified	0.450539959175894	0.326160574104522	no	1585	0.386428920684884	1308	NA	FF|FT	PROTEIN LOCALIZATION|LIPID METABOLISM	MITOCHONDRION		Geranylgeranyl diphosphate synthase, increases the intracellular pool of geranylgeranyl diphosphate, suppressor of bet2 mutation that causes defective geranylgeranylation of small GTP-binding proteins that mediate vesicular traffic	terpenoid biosynthetic process	farnesyltranstransferase activity	mitochondrion
YOR193W	YOR193W	PEX27	hom	Verified	0.450246484491634	0.326266360911901	no	1586	0.323621609112272	1079	NA	FT	PEROXISOME ORGANIZATION			Peripheral peroxisomal membrane protein involved in controlling peroxisome size and number, interacts with homologous protein Pex25p	peroxisome organization	molecular_function	peroxisomal membrane
YIL036W	YIL036W	CST6	hom	Verified	0.450094645150212	0.326321098886079	no	1587	0.246576791014713	897	NA	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Basic leucine zipper (bZIP) transcription factor, in ATF/CREB family; mediates transcriptional activation of NCE103 (encoding carbonic anhydrase) in response to low CO2 levels such as in the ambient air; proposed to be a regulator of oleate responsive genes; involved in utilization of non-optimal carbon sources and chromosome stability; CST6 has a paralog, ACA1, that arose from the whole genome duplication	cellular response to carbon dioxide|positive regulation of transcription from RNA polymerase II promoter by oleic acid|cellular response to oleic acid|positive regulation of transcription from RNA polymerase II promoter|DNA metabolic process	sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YHR193C	YHR193C	EGD2	hom	Verified	0.450005949950468	0.326353075173223	no	1588	0.330277801062869	1088	NA	FT	PROTEIN LOCALIZATION	NUCLEUS		Alpha subunit of the heteromeric nascent polypeptide-associated complex (NAC) involved in protein sorting and translocation, associated with cytoplasmic ribosomes	'de novo' cotranslational protein folding	unfolded protein binding|phosphatidic acid binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4-phosphate binding	nascent polypeptide-associated complex
YBR212W	YBR212W	NGR1	hom	Verified	0.448665431942214	0.326836512420027	no	1589	0.340296143168542	1155	NA	FT	MITOCHONDRION ORGANIZATION			RNA binding protein that negatively regulates growth rate; interacts with the 3' UTR of the mitochondrial porin (POR1) mRNA and enhances its degradation; overexpression impairs mitochondrial function; interacts with Dhh1p to mediate POR1 mRNA decay; expressed in stationary phase	3'-UTR-mediated mRNA destabilization|mitochondrion organization	mRNA binding	cytoplasmic mRNA processing body|cytoplasmic stress granule|perinuclear region of cytoplasm|cytoplasm
YMR124W_p	YMR124W	YMR124W	hom	Uncharacterized	0.447291913974603	0.327332152265674	no	1590	0.31603447066246	1064	NA					Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene; predicted to have a role in organelle organization	biological_process	molecular_function	cytoplasm
YER053C-A	YER053C-A	YER053C-A	hom	Verified	0.44593815463463	0.327820960184787	no	1591	0.3125381080364	1053	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	endoplasmic reticulum
YDR114C_p	YDR114C	YDR114C	hom	Uncharacterized	0.443459923396532	0.328716550452699	no	1592	0.343934206309444	1159	NA					Putative protein of unknown function; deletion mutant exhibits poor growth at elevated pH and calcium	biological_process	molecular_function	cellular_component
YLR389C	YLR389C	STE23	hom	Verified	0.442124188693094	0.329199670787834	no	1593	0.314266751791266	1078	NA	FT	PROTEOLYSIS			Metalloprotease involved, with homolog Axl1p, in N-terminal processing of pro-a-factor to the mature form; expressed in both haploids and diploids; member of the insulin-degrading enzyme family	peptide pheromone maturation	metallopeptidase activity|metalloendopeptidase activity	extrinsic to membrane
YIL165C_p	YIL165C	YIL165C	hom	Uncharacterized	0.441391729871005	0.329464714171687	no	1594	0.31315239139155	1014	NA					Putative protein of unknown function; mutant exhibits mitophagy defects; in closely related species and other S. cerevisiae strain backgrounds YIL165C and adjacent ORF, YIL164C, likely constitute a single ORF encoding a nitrilase gene	mitochondrion degradation	molecular_function	cellular_component
YCR050C_p	YCR050C	YCR050C	hom	Uncharacterized	0.441017037283856	0.329600331442086	no	1595	0.288898370896124	992	NA					Non-essential protein of unknown function; deletion mutant is synthetically sick or lethal with alpha-synuclein	biological_process	molecular_function	cellular_component
YHR022C_p	YHR022C	YHR022C	hom	Uncharacterized	0.440930381829291	0.329631698948321	no	1596	0.311677537558559	1062	NA	FT	SIGNALING			Putative protein of unknown function; YHR022C is not an essential gene	biological_process	molecular_function	cellular_component
YLR202C_d	YLR202C	YLR202C	hom	Dubious	0.44090953338449	0.329639245838774	no	1597	0.329717880541299	1123	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YLR201C; ORF contains a putative intron	Unknown	Unknown	Unknown
YFR023W	YFR023W	PES4	hom	Verified	0.440052256061982	0.329949630135293	no	1598	0.338396245868646	1103	NA	FT		NUCLEUS		Poly(A) binding protein, suppressor of DNA polymerase epsilon mutation; PES4 has a paralog, MIP6, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YCL014W	YCL014W	BUD3	hom	Verified	0.43994025368245	0.329990190170655	no	1599	0.329328777642568	1103	NA	FT	CELL CYCLE|SIGNALING|CELL DIVISION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Protein involved in bud-site selection and required for axial budding pattern; localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding	cellular bud site selection|axial cellular bud site selection|cytokinesis	molecular_function	cellular bud neck contractile ring|cellular bud neck
YMR194C-A_d	YMR194C-A	YMR194C-A	hom	Dubious	0.439936533159739	0.329991537538229	no	1600	0.323472786484188	1089	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YGL131C	YGL131C	SNT2	hom	Verified	0.439436475310504	0.330172650898957	no	1601	0.32329813942654	1083	NA	FT		NUCLEUS|CHROMOSOME		DNA binding protein with similarity to the S. pombe Snt2 protein; RING finger ubiquitin ligase (E3) involved in ubiquitylation and degradation of excess histones; interacts with Ubc4p; null mutant sensitive to hydroxyurea (HU); computational analysis suggests that Snt2p is a transcription factor with a role in regulation of expression of genes encoding amine transporters; relocalizes from nucleus to cytoplasm upon DNA replication stress	biological_process	DNA binding	nucleus|Snt2C complex|cytoplasm
YLR420W	YLR420W	URA4	hom	Verified	0.438646136536732	0.330458980756058	no	1602	0.339978687445237	1163	NA	FT	NUCLEOTIDE METABOLISM	NUCLEUS		Dihydroorotase, catalyzes the third enzymatic step in the de novo biosynthesis of pyrimidines, converting carbamoyl-L-aspartate into dihydroorotate	'de novo' pyrimidine nucleobase biosynthetic process|pyrimidine nucleotide biosynthetic process	dihydroorotase activity	nucleus|cytoplasm
YER085C_p	YER085C	YER085C	hom	Uncharacterized	0.435603356265957	0.33156226763151	no	1603	0.316164677162024	1078	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YNL281W	YNL281W	HCH1	hom	Verified	0.435364792973387	0.331648830670939	no	1604	0.30086180840728	1009	NA	FT	NUCLEOTIDE METABOLISM	NUCLEUS		Heat shock protein regulator; binds to Hsp90p and may stimulate ATPase activity; originally identified as a high-copy number suppressor of a HSP90 loss-of-function mutation; GFP-fusion protein localizes to the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress	protein folding|response to stress	ATPase activator activity|chaperone binding	nucleus|cytoplasm
YDL033C	YDL033C	SLM3	hom	Verified	0.434803424998649	0.331852559325175	no	1605	0.341255309164745	1169	NA	FT	RNA PROCESSING|MITOCHONDRION ORGANIZATION	MITOCHONDRION		tRNA-specific 2-thiouridylase, responsible for 2-thiolation of the wobble base of mitochondrial tRNAs; human ortholog is implicated in myoclonus epilepsy associated with ragged red fibers (MERRF)	mitochondrial tRNA thio-modification	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity	mitochondrion
YPL201C	YPL201C	YIG1	hom	Verified	0.431538722752555	0.333038351530941	no	1606	0.333589041414258	1142	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS		Protein that interacts with glycerol 3-phosphatase and plays a role in anaerobic glycerol production; localizes to the nucleus and cytosol	glycerol biosynthetic process	molecular_function	cytosol|nucleus
YDR391C_p	YDR391C	YDR391C	hom	Uncharacterized	0.431288781296863	0.333129203299837	no	1607	0.334365537640173	1094	NA	FT		NUCLEUS		Putative protein of unknown function, possibly involved in zinc homeostasis; Bdf1p-dependent transcription induced by salt stress; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus	biological_process	molecular_function	nucleus|cytoplasm
YPR154W	YPR154W	PIN3	hom	Verified	0.430710921200286	0.333339288426052	no	1608	0.335986396281643	1132	NA	FT	CYTOSKELETON ORGANIZATION	NUCLEUS		Protein that induces appearance of [PIN+] prion when overproduced	actin cytoskeleton organization	molecular_function	nucleus|cytoplasm
YCL008C	YCL008C	STP22	hom	Verified	0.430268634046006	0.33350012038349	no	1609	0.350206469993971	1167	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEOLYSIS|VACUOLAR TRANSPORT	PLASMA MEMBRANE		Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; homologous to the mouse and human Tsg101 tumor susceptibility gene; mutants exhibit a Class E Vps phenotype	protein targeting to membrane|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|late endosome to vacuole transport|protein targeting to vacuole	ubiquitin binding	endosome|ESCRT I complex|internal side of plasma membrane
YHR081W	YHR081W	LRP1	hom	Verified	0.430222341580865	0.333516955804912	no	1610	0.290673913656011	969	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|RNA LOCALIZATION	NUCLEUS		Nuclear exosome-associated nucleic acid binding protein; involved in RNA processing, surveillance, degradation, tethering, and export; homolog of mammalian nuclear matrix protein C1D involved in regulation of DNA repair and recombination	U5 snRNA 3'-end processing|nuclear mRNA surveillance|nuclear polyadenylation-dependent CUT catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|nuclear retention of pre-mRNA at the site of transcription|U4 snRNA 3'-end processing|polyadenylation-dependent snoRNA 3'-end processing|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	double-stranded RNA binding|double-stranded DNA binding	nuclear exosome (RNase complex)
YNL175C	YNL175C	NOP13	hom	Verified	0.429769088508518	0.333681810414333	no	1611	0.348275673977179	1152	NA	FT		NUCLEUS		Nucleolar protein found in preribosomal complexes; contains an RNA recognition motif (RRM); relative distribution to the nucleolus increases upon DNA replication stress	biological_process	RNA binding	nucleolus|preribosome
YIR032C	YIR032C	DAL3	hom	Verified	0.429047466043193	0.333944341058716	no	1612	0.341805278568691	1166	NA	FT		PLASMA MEMBRANE		Ureidoglycolate hydrolase, converts ureidoglycolate to glyoxylate and urea in the third step of allantoin degradation; expression sensitive to nitrogen catabolite repression	allantoin catabolic process	ureidoglycolate hydrolase activity	membrane
YGL053W	YGL053W	PRM8	hom	Verified	0.427187416151786	0.334621413091384	no	1613	0.325252402608666	1097	NA	FT	VESICLE-MEDIATED TRANSPORT	ENDOPLASMIC RETICULUM|PLASMA MEMBRANE		Pheromone-regulated protein with 2 predicted transmembrane segments and an FF sequence, a motif involved in COPII binding; forms a complex with Prp9p in the ER; member of DUP240 gene family	biological_process	molecular_function	integral to membrane|endoplasmic reticulum|plasma membrane
YOR309C_d	YOR309C	YOR309C	hom	Dubious	0.426818490273532	0.334755768884411	no	1614	0.352393357763187	1173	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NOP58	Unknown	Unknown	Unknown
YML078W	YML078W	CPR3	hom	Verified	0.426753944693419	0.334779277333015	no	1615	0.343080027126735	1153	NA	FT		MITOCHONDRION		Mitochondrial peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; involved in protein refolding after import into mitochondria	protein folding|apoptotic process	peptidyl-prolyl cis-trans isomerase activity	mitochondrion
YBR150C	YBR150C	TBS1	hom	Verified	0.425665793830105	0.335175695281055	no	1616	0.319661500395976	1080	NA	FT	TRANSCRIPTION FROM RNA POL II	ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; TBS1 has a paralog, HAL9, that arose from the whole genome duplication	biological_process	sequence-specific DNA binding	mitochondrion|nucleus|cytoplasm
YMR155W_p	YMR155W	YMR155W	hom	Uncharacterized	0.425518423173614	0.335229397162149	no	1617	0.32800610790901	1128	NA					Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen	biological_process	molecular_function	integral to membrane
YKL190W	YKL190W	CNB1	hom	Verified	0.424567299036749	0.335576067851061	no	1618	0.336089004754989	1129	NA	FF|FT	SIGNALING|ION HOMEOSTASIS|CELL WALL ORG/BIOGENESIS|ION HOMEOSTASIS			Calcineurin B; the regulatory subunit of calcineurin, a Ca++/calmodulin-regulated type 2B protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is encoded by CNA1 and/or CMP1; protein abundance increases in response to DNA replication stress	adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion|fungal-type cell wall organization|cellular ion homeostasis	calcium-dependent protein serine/threonine phosphatase activity|calcium ion binding	calcineurin complex
YLL055W	YLL055W	YCT1	hom	Verified	0.422986599759365	0.33615251896535	no	1619	0.309163238927268	1022	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|PLASMA MEMBRANE		High-affinity cysteine-specific transporter with similarity to the Dal5p family of transporters; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YCT1 is not an essential gene	cysteine transport	ion transmembrane transporter activity|cysteine transmembrane transporter activity	integral to membrane|endoplasmic reticulum
YER040W	YER040W	GLN3	hom	Verified	0.421546421623007	0.336678060372789	no	1620	0.325279845921145	1121	NA	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Transcriptional activator of genes regulated by nitrogen catabolite repression (NCR), localization and activity regulated by quality of nitrogen source	nitrogen catabolite activation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	cytosol|nucleus
YBR144C_d	YBR144C	YBR144C	hom	Dubious	0.421307395688195	0.336765315227862	no	1621	0.317586379047968	1050	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR144C is not an essential gene	Unknown	Unknown	Unknown
YOR304C-A_p	YOR304C-A	YOR304C-A	hom	Uncharacterized	0.420454435323705	0.337076754432579	no	1622	0.345483249427224	1145	NA	FT		SITE OF POLARIZED GROWTH		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck	biological_process	molecular_function	cellular bud|mating projection tip|cellular bud neck|cytoplasm
YOR099W	YOR099W	KTR1	hom	Verified	0.419447219913066	0.337444660210181	no	1623	0.326067987597878	1110	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Alpha-1,2-mannosyltransferase; involved in O- and N-linked protein glycosylation; type II membrane protein; member of the KRE2/MNT1 mannosyltransferase family; relocalizes from vacuole to cytoplasm upon DNA replication stress	N-glycan processing|cell wall mannoprotein biosynthetic process|protein O-linked glycosylation	alpha-1,2-mannosyltransferase activity	Golgi apparatus
YMR152W	YMR152W	YIM1	hom	Verified	0.419388933656712	0.337465955204372	no	1624	0.326983184187499	1120	NA	FT	RESPONSE TO DNA DAMAGE|OXIDATION-REDUCTION PROCESS	MITOCHONDRION		Protein of unknown function; null mutant displays sensitivity to DNA damaging agents; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress	response to DNA damage stimulus	molecular_function	mitochondrion|lipid particle|cytoplasm
YDL149W	YDL149W	ATG9	hom	Verified	0.419248601284719	0.337517228037658	no	1625	0.324795704910402	1054	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS	ENDOMEMBRANE SYSTEM|MITOCHONDRION		Transmembrane protein involved in forming Cvt and autophagic vesicles; cycles between the phagophore assembly site (PAS) and other cytosolic punctate structures, not found in autophagosomes; may be involved in membrane delivery to the PAS	piecemeal microautophagy of nucleus|mitochondrion degradation|protein homooligomerization|CVT pathway|autophagic vacuole assembly	molecular_function	mitochondrion|integral to membrane|pre-autophagosomal structure
YML101C-A_d	YML101C-A	YML101C-A	hom	Dubious	0.41873338303186	0.337705497704803	no	1626	0.335937323640227	1116	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDL050C_d	YDL050C	YDL050C	hom	Dubious	0.418614375387393	0.337748990934551	no	1627	0.322642674825842	1090	NA					Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YHR139C	YHR139C	SPS100	hom	Verified	0.418597842813186	0.337755033197237	no	1628	0.344886519950215	1171	NA	FT	KETONE METABOLISM|CELL CYCLE|AMINO ACID METABOLISM|CELL WALL ORG/BIOGENESIS			Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall; expression also induced in cells treated with the mycotoxin patulin	ascospore wall assembly	molecular_function	ascospore wall
YMR289W	YMR289W	ABZ2	hom	Verified	0.418443897554886	0.337811298535279	no	1629	0.347417643200465	1162	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM			Aminodeoxychorismate lyase (4-amino-4-deoxychorismate lyase), catalyzes the third step in para-aminobenzoic acid biosynthesis; involved in folic acid biosynthesis	folic acid biosynthetic process	4-amino-4-deoxychorismate lyase activity	cytoplasm
YBR196C-A_p	YBR196C-A	YBR196C-A	hom	Uncharacterized	0.415595432506443	0.338853034748209	no	1630	0.371780981385221	1235	NA					Putative protein of unknown function; identified by fungal homology and RT-PCR	biological_process	molecular_function	cellular_component
YER049W	YER049W	TPA1	hom	Verified	0.413901739891828	0.339473034809155	no	1631	0.329795392621519	1070	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|OXIDATION-REDUCTION PROCESS	NUCLEUS		Poly(rA)-binding protein involved in translation termination efficiency, mRNA poly(A) tail length and mRNA stability; interacts with Sup45p (eRF1), Sup35p (eRF3) and Pab1p; similar to prolyl 4-hydroxylases; binds Fe(III) and 2-oxoglutarate	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|translational termination	poly(A) RNA binding	nucleus
YBR051W_d	YBR051W	YBR051W	hom	Dubious	0.413404966114282	0.339654968385724	no	1632	0.334233689613297	1127	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partiallly overlaps the REG2/YBR050C regulatory subunit of the Glc7p type-1 protein phosphatase	Unknown	Unknown	Unknown
YNR014W_p	YNR014W	YNR014W	hom	Uncharacterized	0.413331997074302	0.339681695002642	no	1633	0.350159195648815	1178	NA					Putative protein of unknown function; expression is cell-cycle regulated, Azf1p-dependent, and heat-inducible; YNR014W has a paralog, YMR206W, that arose from the whole genome duplication	biological_process	molecular_function	cytoplasm
YKL094W	YKL094W	YJU3	hom	Verified	0.413203748595818	0.339728670959714	no	1634	0.337378553796401	1166	NA	FT	LIPID METABOLISM	ENDOPLASMIC RETICULUM|MITOCHONDRION		Monoglyceride lipase (MGL), functional ortholog of mammalian MGL, localizes to lipid particles and membranes, also member of the eukaryotic serine hydrolase family	triglyceride metabolic process	serine hydrolase activity|acylglycerol lipase activity	mitochondrial outer membrane|lipid particle|plasma membrane|membrane|cytoplasm
YJL079C	YJL079C	PRY1	hom	Verified	0.413024769309438	0.339794233195147	no	1635	0.300190693805022	1042	NA	FT		ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM		Sterol binding protein involved in the export of acetylated sterols; secreted glycoprotein and member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis related 1 proteins); sterol export function is redundant with that of PRY2; may be involved in detoxification of hydrophobic compounds; PRY1 has a paralog, PRY2, that arose from the whole genome duplication	biological_process	molecular_function	nuclear envelope|extracellular region|endoplasmic reticulum|fungal-type vacuole
YDR445C_d	YDR445C	YDR445C	hom	Dubious	0.412715637157539	0.339907483382949	no	1636	0.361368307865259	1230	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YGR023W	YGR023W	MTL1	hom	Verified	0.412683659099104	0.339919199330598	no	1637	0.335661993321148	1105	NA	FT	CELL WALL ORG/BIOGENESIS|RESPONSE TO NUTRIENT LEVELS|RESPONSE TO OXIDATIVE STRESS	PLASMA MEMBRANE		Putative plasma membrane sensor, involved in cell integrity signaling and stress response during glucose starvation and oxidative stress; has structural and functional similarity to Mid2p	cellular response to glucose starvation|fungal-type cell wall organization|cellular response to oxidative stress	molecular_function	integral to plasma membrane
YKL131W_d	YKL131W	YKL131W	hom	Dubious	0.412353209820907	0.340040276597502	no	1638	0.311075105144306	1106	NA					Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YLR426W_p	YLR426W	TDA5	hom	Uncharacterized	0.411732781758933	0.340267647223712	no	1639	0.385385599983203	1261	NA	FT	OXIDATION-REDUCTION PROCESS	MITOCHONDRION		Putative protein of unknown function; detected in highly purified mitochondria in high-throughput studies; proposed to be involved in resistance to mechlorethamine and streptozotocin; null mutant sensitive to expression of top1-T722A allele	response to drug	molecular_function	mitochondrion|integral to membrane
YLR004C	YLR004C	THI73	hom	Verified	0.41061761138557	0.340676473934414	no	1640	0.321141084378791	1093	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|PLASMA MEMBRANE		Putative plasma membrane permease proposed to be involved in carboxylic acid uptake and repressed by thiamine; substrate of Dbf2p/Mob1p kinase; transcription is altered if mitochondrial dysfunction occurs	transport	transporter activity	integral to membrane|endoplasmic reticulum
YGL190C	YGL190C	CDC55	hom	Verified	0.410347373154153	0.340775572744552	no	1641	0.448757693811631	1478	NA	FT	CELL CYCLE|SIGNALING	NUCLEUS|SITE OF POLARIZED GROWTH		Non-essential regulatory subunit B of protein phosphatase 2A (PP2A); localization to the cytoplasm requires Zds1p and Zds2p and promotes mitotic entry; localization to the nucleus prevents mitotic exit; required for correct nuclear division and chromosome segregation in meiosis; maintains nucleolar sequestration of Cdc14p during early meiosis; limits formation of PP2A-Rts1p holocomplexes to ensure timely dissolution of sister chromosome cohesion	negative regulation of exit from mitosis|positive regulation of G2/M transition of mitotic cell cycle|cell shape checkpoint|protein dephosphorylation	protein phosphatase type 2A regulator activity	nucleus|cellular bud neck|cytoplasm|cellular bud tip
YDL185W	YDL185W	VMA1	hom	Verified	0.410337078102539	0.340779348250689	no	1642	0.394053568287945	1287	NA	FF|FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS	ENDOMEMBRANE SYSTEM		Subunit A of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase; protein precursor undergoes self-catalyzed splicing to yield the extein Tfp1p and the intein Vde (PI-SceI), which is a site-specific endonuclease	intron homing|cellular protein metabolic process|vacuolar acidification	endodeoxyribonuclease activity|proton-transporting ATPase activity, rotational mechanism	vacuolar proton-transporting V-type ATPase, V1 domain|fungal-type vacuole membrane
YMR241W	YMR241W	YHM2	hom	Verified	0.410238254041547	0.340815590827742	no	1643	0.346601237021664	1171	NA	FT	ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS	MITOCHONDRION		Carrier protein that exports citrate from and imports oxoglutarate into the mitochondrion, causing net export of NADPH reducing equivalents; also associates with mt nucleoids and has a role in replication and segregation of the mt genome	tricarboxylic acid transport|mitochondrial citrate transport|alpha-ketoglutarate transport|mitochondrial genome maintenance	tricarboxylate secondary active transmembrane transporter activity|DNA binding	mitochondrial nucleoid|mitochondrion|integral to membrane|mitochondrial inner membrane
YDL159W-A_p	YDL159W-A	YDL159W-A	hom	Uncharacterized	0.410143059268112	0.340850503795126	no	1644	0.338042464880075	1124	NA					Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species	biological_process	molecular_function	cellular_component
YKL135C	YKL135C	APL2	hom	Verified	0.41005822135731	0.340881619500984	no	1645	0.364752247000575	1241	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS|PLASMA MEMBRANE		Beta-adaptin subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in clathrin-dependent Golgi protein sorting; protein abundance increases in response to DNA replication stress	Golgi to vacuole transport|vesicle-mediated transport	clathrin binding	AP-1 adaptor complex
YJL121C	YJL121C	RPE1	hom	Verified	0.408953865942252	0.341286758790846	no	1646	0.361582873585047	1220	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS			D-ribulose-5-phosphate 3-epimerase, catalyzes a reaction in the non-oxidative part of the pentose-phosphate pathway; mutants are sensitive to oxidative stress	pentose-phosphate shunt	ribulose-phosphate 3-epimerase activity	cytosol
YGR062C	YGR062C	COX18	hom	Verified	0.407480032350291	0.341827728357512	no	1647	0.338155525645375	1146	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial integral inner membrane protein required for membrane insertion of C-terminus of Cox2p; interacts genetically and physically with Mss2p and Pnt1p; similar to S. cerevisiae Oxa1, N. crassa Oxa2p, and E. coli YidC	protein insertion into mitochondrial membrane from inner side	membrane insertase activity	integral to membrane|integral to mitochondrial inner membrane
YJL157C	YJL157C	FAR1	hom	Verified	0.40697263058485	0.342014045062713	no	1648	0.301561956159614	1025	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|SIGNALING|CELL DIVISION	NUCLEUS|SITE OF POLARIZED GROWTH		Cyclin-dependent kinase inhibitor; mediates cell cycle arrest in response to pheromone; also forms a complex with Cdc24p, Ste4p, and Ste18p that may specify the direction of polarized growth during mating; potential Cdc28p substrate; relocalizes from nucleus to cytoplasm upon DNA replication stress	maintenance of protein location in nucleus|pheromone-dependent signal transduction involved in conjugation with cellular fusion|cell cycle arrest in response to pheromone	cyclin-dependent protein kinase inhibitor activity	nucleus|mating projection tip|membrane|cytoplasm
YPR099C_d	YPR099C	YPR099C	hom	Dubious	0.405718311867051	0.342474792917626	no	1649	0.327031740827666	1087	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene MRPL51/YPR100W	Unknown	Unknown	Unknown
YOR359W	YOR359W	VTS1	hom	Verified	0.405567785803483	0.342530101305336	no	1650	0.364292827881343	1191	NA	FT	PROTEIN LOCALIZATION|RNA PROCESSING	NUCLEUS		Flap-structured DNA-binding and RNA-binding protein; stimulates deadenylation-dependent mRNA degradation mediated by the CCR4-NOT deadenylase complex; member of the Smaug (Smg) family of post-transcriptional regulators which bind RNA through a conserved sterile alpha motif (SAM) domain that interacts with Smg recognition element (SREs) containing transcripts; stimulates Dna2p endonuclease activity	nuclear-transcribed mRNA catabolic process|positive regulation of endodeoxyribonuclease activity|nuclear-transcribed mRNA poly(A) tail shortening	flap-structured DNA binding|RNA binding	cytosol|nucleus|cytoplasmic mRNA processing body
YOR304W	YOR304W	ISW2	hom	Verified	0.405368290841081	0.342603407732295	no	1651	0.326943978987998	1111	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS		ATP-dependent DNA translocase involved in chromatin remodeling; ATPase component that, with Itc1p, forms a complex required for repression of a-specific genes, INO1, and early meiotic genes during mitotic growth	negative regulation of transcription from RNA polymerase II promoter by pheromones|nucleosome positioning|termination of RNA polymerase II transcription|negative regulation of antisense RNA transcription|chromatin silencing at rDNA|chromatin remodeling|chromatin silencing at telomere	single-stranded DNA binding|DNA translocase activity	chromatin accessibility complex|nucleus
YJL098W	YJL098W	SAP185	hom	Verified	0.404909123937989	0.342772155742887	no	1652	0.346687896196294	1145	NA	FT	CELL CYCLE|RNA PROCESSING	MITOCHONDRION		Protein that forms a complex with the Sit4p protein phosphatase; required for Sit4p function; member of a family of similar proteins including Sap4p, Sap155p, and Sap190p; SAP185 has a paralog, SAP190, that arose from the whole genome duplication	tRNA wobble uridine modification|G1/S transition of mitotic cell cycle	protein serine/threonine phosphatase activity	mitochondrion|cytoplasm
YMR278W	YMR278W	PGM3	hom	Verified	0.404848339423911	0.342794496956724	no	1653	0.322838790105568	1094	NA	FT	CARBOHYDRATE METABOLISM	NUCLEUS		Phosphoglucomutase, catalyzes interconversion of glucose-1-phosphate and glucose-6-phospate; transcription induced in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; non-essential	biological_process	phosphoglucomutase activity	nucleus|cytoplasm
YIR025W	YIR025W	MND2	hom	Verified	0.404608816665207	0.342882538368495	no	1654	0.351154248848999	1151	NA	FT	CELL CYCLE|CELL DIVISION|PROTEOLYSIS|CHROMOSOME SEGREGATION	NUCLEUS	UBIQUITIN LIGASE COMPLEX	Subunit of the anaphase-promoting complex (APC); necessary for maintaining sister chromatid cohesion in prophase I of meiosis by inhibiting premature ubiquitination and subsequent degradation of substrates by the APC(Ama1) ubiquitin ligase	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|reciprocal meiotic recombination|regulation of mitotic metaphase/anaphase transition|protein ubiquitination|mitotic sister chromatid segregation	molecular_function	nucleus|anaphase-promoting complex
YEL014C_d	YEL014C	YEL014C	hom	Dubious	0.403916425412574	0.343137088680617	no	1655	0.325915930382536	1081	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDL081C	YDL081C	RPP1A	hom	Verified	0.402362044644149	0.343708799490679	no	1656	0.339791841999634	1134	NA	FT	TRANSLATION		RIBOSOME	Ribosomal stalk protein P1 alpha, involved in the interaction between translational elongation factors and the ribosome; accumulation of P1 in the cytoplasm is regulated by phosphorylation and interaction with the P2 stalk component	cytoplasmic translation|translational elongation	structural constituent of ribosome	cytosolic large ribosomal subunit
YLR460C_p	YLR460C	YLR460C	hom	Uncharacterized	0.400793714126666	0.344286003603381	no	1657	0.31928197821497	1060	NA	FT	OXIDATION-REDUCTION PROCESS			Member of the quinone oxidoreductase family, up-regulated in response to the fungicide mancozeb; possibly up-regulated by iodine	biological_process	molecular_function	cellular_component
YPR044C_d	YPR044C	OPI11	hom	Dubious	0.400283160440659	0.344473984761204	no	1658	0.345742183745426	1156	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene RPL43A/YPR043W; deletion confers sensitivity to GSAO	Unknown	Unknown	Unknown
YER097W_d	YER097W	YER097W	hom	Dubious	0.398682187638705	0.34506369712457	no	1659	0.386322185573557	1282	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YNL201C	YNL201C	PSY2	hom	Verified	0.398024212955634	0.345306168889552	no	1660	0.390988001744437	1258	NA	FT	CELL CYCLE|SIGNALING|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Subunit of protein phosphatase PP4 complex; active complex is composed of catalytic subunit Pph3p and Psy2p, with Psy4p apparently providing additional substrate specificity in some cases; regulates recovery from the DNA damage checkpoint and also the gene conversion- and single-strand annealing-mediated pathways of meiotic double-strand break repair; Pph3p and Psy2p localize to foci on meiotic chromosomes; putative homolog of mammalian R3	Unknown|response to DNA damage stimulus|protein dephosphorylation|signal transduction involved in meiotic recombination checkpoint	protein serine/threonine phosphatase activity	condensed nuclear chromosome|nucleus
YLR384C	YLR384C	IKI3	hom	Verified	0.397374442773069	0.345545679521799	no	1661	0.328792345296655	1106	NA	FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|RNA PROCESSING	NUCLEUS		Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator; homolog of human IKAP, mutations in which cause familial dysautonomia (FD)	regulation of transcription from RNA polymerase II promoter|tRNA wobble uridine modification	molecular_function	Elongator holoenzyme complex|nucleus|cytoplasm
YKL202W_d	YKL202W	YKL202W	hom	Dubious	0.397035355843238	0.345670694318191	no	1662	0.314571543720444	1075	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDR492W	YDR492W	IZH1	hom	Verified	0.396604798668983	0.345829456678893	no	1663	0.342323714060108	1169	NA	FT	LIPID METABOLISM|ION HOMEOSTASIS|ION HOMEOSTASIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family; transcription is regulated directly by Zap1p, expression induced by zinc deficiency and fatty acids; deletion increases sensitivity to elevated zinc	response to zinc ion|cellular zinc ion homeostasis|cellular lipid metabolic process	metal ion binding	integral to membrane|endoplasmic reticulum|membrane
YBR280C	YBR280C	SAF1	hom	Verified	0.396411656153862	0.345900684281119	no	1664	0.348931295461057	1191	NA	FT	PROTEOLYSIS		UBIQUITIN LIGASE COMPLEX	F-Box protein involved in proteasome-dependent degradation of Aah1p during entry of cells into quiescence; interacts with Skp1	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	ubiquitin-protein ligase activity	SCF ubiquitin ligase complex
YJL047C-A_p	YJL047C-A	YJL047C-A	hom	Uncharacterized	0.396391069633975	0.345908276553467	no	1665	0.342184366627183	1128	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YBR194W	YBR194W	AIM4	hom	Verified	0.396042379689032	0.346036882201922	no	1666	0.380126579094761	1255	NA					Protein proposed to be associated with the nuclear pore complex; null mutant is viable, displays elevated frequency of mitochondrial genome loss and is sensitive to freeze-thaw stress	biological_process	molecular_function	cytoplasm
YEL064C	YEL064C	AVT2	hom	Verified	0.394570910801569	0.346579792518157	no	1667	0.325839742317639	1104	NA	FT		ENDOPLASMIC RETICULUM		Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters	transport	transporter activity	integral to membrane|endoplasmic reticulum
YDR272W	YDR272W	GLO2	hom	Verified	0.394566367728991	0.346581469210189	no	1668	0.359007788299898	1219	NA	FT	KETONE METABOLISM|CARBOHYDRATE METABOLISM			Cytoplasmic glyoxalase II, catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate	cellular carbohydrate metabolic process|methylglyoxal catabolic process to D-lactate	hydroxyacylglutathione hydrolase activity	cytoplasm
YDR378C	YDR378C	LSM6	hom	Verified	0.394543603184988	0.346589870866669	no	1669	0.35562770108627	1194	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA	nuclear-transcribed mRNA catabolic process|mRNA splicing, via spliceosome|maturation of SSU-rRNA	RNA binding	U6 snRNP|nucleolus|small nucleolar ribonucleoprotein complex|U4/U6 x U5 tri-snRNP complex|cytoplasmic mRNA processing body
YFR032C-B_p	YFR032C-B	YFR032C-B	hom	Uncharacterized	0.393889023995881	0.346831487127983	no	1670	0.331659412403228	1142	NA					Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching	biological_process	molecular_function	cellular_component
YNL289W	YNL289W	PCL1	hom	Verified	0.393553133725978	0.346955494107172	no	1671	0.343995529983847	1161	NA	FT	CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Cyclin, interacts with cyclin-dependent kinase Pho85p; member of the Pcl1,2-like subfamily, involved in the regulation of polarized growth and morphogenesis and progression through the cell cycle; is ubiquitinated by Dma1p; phosphorylation by Pho85p targets it for degradation; localizes to sites of polarized cell growth	regulation of establishment or maintenance of cell polarity|G1 phase of mitotic cell cycle|regulation of cyclin-dependent protein kinase activity|septin ring organization|positive regulation of macroautophagy	cyclin-dependent protein kinase regulator activity	cyclin-dependent protein kinase holoenzyme complex|incipient cellular bud site|nucleus
YMR244C-A	YMR244C-A	COA6	hom	Verified	0.393188610263329	0.347090090694059	no	1672	0.33946562724499	1119	NA	FT		NUCLEUS|MITOCHONDRION		Protein involved in cytochrome c oxidase assembly; also required for efficient formation of respiratory supercomplexes comprised of Complexes III and IV; localizes to the mitochondrial intermembrane space; has a human homolog; transcription is induced in response to the DNA-damaging agent MMS; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	nucleus|cytoplasm
YGL041C-B_p	YGL041C-B	YGL041C-B	hom	Uncharacterized	0.391569061534848	0.347688325677495	no	1673	0.338496407257323	1133	NA					Putative protein of unknown function; identified by fungal homology and RT-PCR	biological_process	molecular_function	cellular_component
YGR102C	YGR102C	GTF1	hom	Verified	0.391480645775807	0.347720995958747	no	1674	0.346472103162475	1167	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION	MITOCHONDRION		Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is salt sensitive and null mutant has growth defects; non-tagged protein is detected in purified mitochondria	glutaminyl-tRNAGln biosynthesis via transamidation	glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity	mitochondrion|glutamyl-tRNA(Gln) amidotransferase complex
YCR088W	YCR088W	ABP1	hom	Verified	0.390540198589529	0.348068568137707	no	1675	0.339902594356065	1105	NA	FT	PROTEIN LOCALIZATION|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Actin-binding protein of the cortical actin cytoskeleton, important for activation of the Arp2/3 complex that plays a key role actin in cytoskeleton organization; phosphorylation within its PRR (Proline-Rich Region), mediated by Cdc28p and Pho85p, protects Abp1p from proteolysis mediated by its own PEST sequences	protein localization|actin cortical patch assembly	actin filament binding	cell cortex|mating projection tip|cytoplasm|actin cortical patch
YNL097C-B_p	YNL097C-B	YNL097C-B	hom	Uncharacterized	0.389659855332461	0.348394042703649	no	1676	0.327989320824658	1075	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YJR090C	YJR090C	GRR1	hom	Verified	0.389565668881954	0.348428871298761	no	1677	0.382375716738258	1254	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CARBOHYDRATE METABOLISM|PROTEOLYSIS	NUCLEUS|SITE OF POLARIZED GROWTH|CYTOSKELETON	UBIQUITIN LIGASE COMPLEX	F-box protein component of the SCF ubiquitin-ligase complex; involved in carbon catabolite repression, glucose-dependent divalent cation transport, high-affinity glucose transport, morphogenesis, and sulfite detoxification	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|cellular response to methylmercury|cell cycle arrest in response to pheromone|G1/S transition of mitotic cell cycle|response to DNA damage stimulus|protein ubiquitination	ubiquitin-protein ligase activity|protein binding, bridging	cellular bud neck contractile ring|SCF ubiquitin ligase complex|nucleus|cytoplasm
YDR533C	YDR533C	HSP31	hom	Verified	0.388940425269924	0.348660108456023	no	1678	0.360195358490725	1213	NA	FT	PROTEOLYSIS			Possible chaperone and cysteine protease; has similarity to E. coli Hsp31; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease; exists as a dimer and contains a putative metal-binding site; protein abundance increases in response to DNA replication stress	biological_process	unfolded protein binding|cysteine-type peptidase activity	cellular_component
YGL177W_d	YGL177W	YGL177W	hom	Dubious	0.387386529145454	0.349235037495485	no	1679	0.380807850497135	1267	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YFR057W_p	YFR057W	YFR057W	hom	Uncharacterized	0.387049061529882	0.349359943589126	no	1680	0.361795332859232	1233	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YAL056C-A_d	YAL056C-A	YAL056C-A	hom	Dubious	0.38584008075884	0.349807554636438	no	1681	0.368725610847989	1240	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YIL017C	YIL017C	VID28	hom	Verified	0.384973476389751	0.350128533346971	no	1682	0.343095128769463	1152	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|CARBOHYDRATE METABOLISM|PROTEOLYSIS	NUCLEUS		GID Complex subunit, serves as adaptor for regulatory subunit Vid24p; protein involved in proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBPase); localized to the nucleus and the cytoplasm	negative regulation of gluconeogenesis|proteasomal ubiquitin-dependent protein catabolic process|vacuolar protein catabolic process|ascospore formation|positive regulation of transcription from RNA polymerase II promoter	molecular_function	nucleus|GID complex|cytoplasm
YIL153W	YIL153W	RRD1	hom	Verified	0.38435381703308	0.35035811259907	no	1683	0.362342187683458	1195	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|RESPONSE TO DNA DAMAGE|CYTOSKELETON ORGANIZATION	NUCLEUS|CHROMOSOME		Peptidyl-prolyl cis/trans-isomerase; activator of the phosphotyrosyl phosphatase activity of PP2A; involved in G1 phase progression, microtubule dynamics, bud morphogenesis and DNA repair; required for rapid reduction of Sgs1p levels in response to rapamycin; subunit of the Tap42p-Sit4p-Rrd1p complex; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress	DNA repair|mitotic spindle organization in nucleus|G1/S transition of mitotic cell cycle|response to osmotic stress|regulation of transcription from RNA polymerase II promoter in response to stress	peptidyl-prolyl cis-trans isomerase activity|protein phosphatase type 2A regulator activity	nuclear chromatin|nucleus|cytoplasm
YJL146W	YJL146W	IDS2	hom	Verified	0.384314493167925	0.350372683649103	no	1684	0.337516727734681	1124	NA	FT	CELL CYCLE	NUCLEUS		Protein involved in modulation of Ime2p activity during meiosis, appears to act indirectly to promote Ime2p-mediated late meiotic functions; found in growing cells and degraded during sporulation	meiosis	molecular_function	nucleus|cytoplasm
YMR233W	YMR233W	TRI1	hom	Verified	0.383741064641379	0.350585186645649	no	1685	0.362569421295431	1209	NA	FT		NUCLEUS		Non-essential sumoylated protein of unknown function; similar to components of human SWI/SNF complex including SMRD3; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm, nucleus and nucleolus; TRI1 has a paralog, UAF30, that arose from the whole genome duplication	biological_process	molecular_function	nucleolus|nucleus|cytoplasm
YKR024C	YKR024C	DBP7	hom	Verified	0.383025493733505	0.350850430809778	no	1686	0.354849797455068	1180	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Putative ATP-dependent RNA helicase of the DEAD-box family involved in ribosomal biogenesis; essential for growth under anaerobic conditions	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	ATP-dependent RNA helicase activity	nucleolus
YPL120W	YPL120W	VPS30	hom	Verified	0.382765762276776	0.350946724728926	no	1687	0.352108383736824	1209	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|MEMBRANE ORGANIZATION|PROTEOLYSIS|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS|PEROXISOME ORGANIZATION			Subunit of phosphatidylinositol (PtdIns) 3-kinase complexes I and II; Complex I is essential in autophagy and Complex II is required for vacuolar protein sorting; required for overflow degradation of misfolded proteins when ERAD is saturated; ortholog of the higher eukaryotic gene Beclin 1	phosphatidylinositol biosynthetic process|piecemeal microautophagy of nucleus|ER-associated protein catabolic process|peroxisome degradation|retrograde transport, endosome to Golgi|macroautophagy|CVT pathway|late endosome to vacuole transport	1-phosphatidylinositol-3-kinase activity	phosphatidylinositol 3-kinase complex I|phosphatidylinositol 3-kinase complex II|extrinsic to membrane|cytoplasm
YML053C_p	YML053C	YML053C	hom	Uncharacterized	0.382621360916904	0.351000264830156	no	1688	0.347456739317287	1152	NA	FT		NUCLEUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; overexpression causes a cell cycle delay or arrest; YML053C is not an essential gene	biological_process	molecular_function	nucleus|cytoplasm
YNL086W_p	YNL086W	SNN1	hom	Uncharacterized	0.379044836574736	0.352327284477732	no	1689	0.338547078130181	1136	NA					Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to endosomes	biological_process	molecular_function	endosome|BLOC-1 complex
YJL080C	YJL080C	SCP160	hom	Verified	0.378882875997057	0.352387420415055	no	1690	0.337196113412794	1167	NA	FT	CELL CYCLE|SIGNALING|RNA LOCALIZATION|CHROMOSOME SEGREGATION|GENE SILENCING	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM		Essential RNA-binding G protein effector of mating response pathway, mainly associated with nuclear envelope and ER, interacts in mRNA-dependent manner with translating ribosomes via multiple KH domains, similar to vertebrate vigilins	meiotic telomere clustering|pheromone-dependent signal transduction involved in conjugation with cellular fusion|chromosome segregation|intracellular mRNA localization|chromatin silencing at silent mating-type cassette|chromatin silencing at telomere	G-protein alpha-subunit binding|RNA binding	endoplasmic reticulum membrane|polysome|nuclear outer membrane-endoplasmic reticulum membrane network
YDR169C-A_p	YDR169C-A	YDR169C-A	hom	Uncharacterized	0.377721613161544	0.352818705131831	no	1691	0.370554888884523	1223	NA					Putative protein of unknown function; identified by fungal homology and RT-PCR	biological_process	molecular_function	cellular_component
YHR017W	YHR017W	YSC83	hom	Verified	0.377297940637338	0.352976101215267	no	1692	0.37011903070403	1226	NA	FT		MITOCHONDRION		Non-essential mitochondrial protein of unknown function; mRNA induced during meiosis, peaking between mid to late prophase of meiosis I; similar to S. douglasii YSD83	biological_process	molecular_function	mitochondrial outer membrane|mitochondrion
YKL184W	YKL184W	SPE1	hom	Verified	0.374701701218584	0.353941163451315	no	1693	0.356864345572654	1216	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM			Ornithine decarboxylase, catalyzes the first step in polyamine biosynthesis; degraded in a proteasome-dependent manner in the presence of excess polyamines; deletion decreases lifespan, and increases necrotic cell death and ROS generation	pantothenate biosynthetic process|putrescine biosynthetic process	ornithine decarboxylase activity	cytoplasm
YOR286W	YOR286W	RDL2	hom	Verified	0.373985817477091	0.354207433923503	no	1694	0.348041972310612	1135	NA	FT		MITOCHONDRION		Protein with rhodanese activity; contains a rhodanese-like domain similar to Rdl1p, Uba4p, Tum1p, and Ych1p; overexpression causes a cell cycle delay; null mutant displays elevated frequency of mitochondrial genome loss	biological_process	thiosulfate sulfurtransferase activity	mitochondrion
YHL028W	YHL028W	WSC4	hom	Verified	0.372452119985694	0.354778127226712	no	1695	0.344035229035283	1141	NA	FT	PROTEIN LOCALIZATION|CELL WALL ORG/BIOGENESIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		ER membrane protein involved in the translocation of soluble secretory proteins and insertion of membrane proteins into the ER membrane; may also have a role in the stress response but has only partial functional overlap with WSC1-3	response to heat|SRP-dependent cotranslational protein targeting to membrane, translocation|protein targeting to ER|response to stress	transmembrane signaling receptor activity	endoplasmic reticulum membrane
YLR445W	YLR445W	GMC2	hom	Verified	0.371197503809008	0.355245216094392	no	1696	0.362312198906104	1196	NA	FT	CELL CYCLE			Protein involved in meiotic progression; mutants are delayed in meiotic nuclear division and are defective in synaptonemal complex assembly; transcription is regulated by Ume6p and induced in response to alpha factor	meiosis|synaptonemal complex organization	molecular_function	cellular_component
YOR062C_p	YOR062C	YOR062C	hom	Uncharacterized	0.370339568314945	0.355564747543614	no	1697	0.337074269116734	1143	NA	FT		NUCLEUS		Protein of unknown function; similar to YKR075Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS	biological_process	molecular_function	nucleus|cytoplasm
YBR018C	YBR018C	GAL7	hom	Verified	0.370292528339981	0.355582270157176	no	1698	0.360545186303257	1199	NA	FT	CARBOHYDRATE METABOLISM			Galactose-1-phosphate uridyl transferase, synthesizes glucose-1-phosphate and UDP-galactose from UDP-D-glucose and alpha-D-galactose-1-phosphate in the second step of galactose catabolism	galactose catabolic process via UDP-galactose	UDP-glucose:hexose-1-phosphate uridylyltransferase activity	cytoplasm
YPL180W	YPL180W	TCO89	hom	Verified	0.369890219754624	0.355732144475915	no	1699	0.36837562822772	1232	NA	FT	SIGNALING|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	PLASMA MEMBRANE		Subunit of TORC1 (Tor1p or Tor2p-Kog1p-Lst8p-Tco89p), a complex that regulates growth in response to nutrient availability; cooperates with Ssd1p in the maintenance of cellular integrity; deletion strains are hypersensitive to rapamycin	TOR signaling cascade|fungal-type cell wall organization|response to salt stress|regulation of cell growth|glycerol metabolic process	molecular_function	TORC1 complex|fungal-type vacuole membrane|extrinsic to internal side of plasma membrane|extrinsic to vacuolar membrane
YLR015W	YLR015W	BRE2	hom	Verified	0.368791596817901	0.356141534321161	no	1700	0.374931608317504	1240	NA	FT	CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS|CHROMOSOME		Subunit of COMPASS (Set1C) complex, which methylates Lys4 of histone H3 and functions in silencing at telomeres; has a C-terminal Sdc1 Dpy-30 Interaction (SDI) domain that mediates binding to Sdc1p; similar to trithorax-group protein ASH2L	histone H3-K4 methylation|telomere maintenance|histone H3-K4 trimethylation|chromatin silencing at telomere	histone methyltransferase activity (H3-K4 specific)	Set1C/COMPASS complex
YPL077C_p	YPL077C	YPL077C	hom	Uncharacterized	0.368410777446819	0.356283481245441	no	1701	0.35895591356475	1190	NA					Putative protein of unknown function; regulates PIS1 expression; mutant displays spore wall assembly defect in ether sensitivity screen; YPL077C is not an essential gene; YPL077C has a paralog, YBR197C, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YNL327W	YNL327W	EGT2	hom	Verified	0.368121310396062	0.356391390754892	no	1702	0.364471928668121	1171	NA	FT	CELL CYCLE|CELL DIVISION			Glycosylphosphatidylinositol (GPI)-anchored cell wall endoglucanase required for proper cell separation after cytokinesis, expression is activated by Swi5p and tightly regulated in a cell cycle-dependent manner	cytokinesis	cellulase activity	fungal-type cell wall|cellular bud|cell septum
YKR105C_p	YKR105C	VBA5	hom	Uncharacterized	0.366831610801302	0.356872313445239	no	1703	0.351185172329551	1177	NA					Plasma membrane protein of the Major Facilitator Superfamily (MFS); involved in amino acid uptake and drug sensitivity; similar to Vba3p	biological_process	molecular_function	integral to membrane
YGR177C	YGR177C	ATF2	hom	Verified	0.366501697605082	0.356995373049233	no	1704	0.347861708526583	1157	NA	FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Alcohol acetyltransferase, may play a role in steroid detoxification; forms volatile esters during fermentation, which is important for brewing and winemaking	steroid metabolic process|response to toxin|Unknown|sterol acetylation	alcohol O-acetyltransferase activity	integral to endoplasmic reticulum membrane|endoplasmic reticulum|cytoplasm
YMR135C	YMR135C	GID8	hom	Verified	0.366360122246586	0.357048186072042	no	1705	0.35793740039159	1168	NA	FT	KETONE METABOLISM|CELL CYCLE|CARBOHYDRATE METABOLISM|PROTEOLYSIS	NUCLEUS		Subunit of GID Complex, binds strongly to central component Vid30p; GID Complex is involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; recruits Rmd5p, Fyv10 and Vid28p to GID Complex; contains LisH, CTLH, and CRA domains that mediate binding to Vid30p (LisH) and Rmd5p and Vid28p (CTLH and CRA); dosage-dependent regulator of START	negative regulation of gluconeogenesis|proteasomal ubiquitin-dependent protein catabolic process|traversing start control point of mitotic cell cycle	molecular_function	nucleus|GID complex|cytoplasm
YOR316C-A_p	YOR316C-A	YOR316C-A	hom	Uncharacterized	0.366349195331449	0.357052262343136	no	1706	0.336262029769825	1136	NA					Putative protein of unknown function; identified by fungal homology and RT-PCR	biological_process	molecular_function	cellular_component
YHR032W	YHR032W	ERC1	hom	Verified	0.366000349067699	0.357182407549696	no	1707	0.346429937082472	1158	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM			Member of the multi-drug and toxin extrusion (MATE) family of the multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter superfamily; overproduction confers ethionine resistance and accumulation of S-adenosylmethionine	S-adenosylmethionine biosynthetic process|transmembrane transport	antiporter activity	integral to membrane
YKL187C	YKL187C	FAT3	hom	Verified	0.365386912262856	0.357411304702599	no	1708	0.335502617687646	1096	NA	FT		MITOCHONDRION		Protein required for fatty acid uptake; Fat3p abundance increases in cortical patches in response to oleate exposure; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion|integral to membrane
YML116W-A_d	YML116W-A	YML116W-A	hom	Dubious	0.365220468623207	0.35747342015719	no	1709	0.329859850172005	1091	NA					Putative protein of unknown function	Unknown	Unknown	Unknown
YOR357C	YOR357C	SNX3	hom	Verified	0.364901684453552	0.357592398437491	no	1710	0.357770656041863	1180	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Sorting nexin required to maintain late-Golgi resident enzymes in their proper location by recycling molecules from the prevacuolar compartment; contains a PX domain and sequence similarity to human Snx3p	protein localization|late endosome to Golgi transport	phosphatidylinositol-3-phosphate binding	cytosol|endosome
YIL070C	YIL070C	MAM33	hom	Verified	0.363124338941538	0.358256001956426	no	1711	0.357738352803944	1193	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Acidic protein of the mitochondrial matrix involved in oxidative phosphorylation; related to the human complement receptor gC1q-R	aerobic respiration	molecular_function	mitochondrion|mitochondrial matrix
YBR021W	YBR021W	FUR4	hom	Verified	0.362850088787372	0.358358436322926	no	1712	0.397088909277346	1332	NA	FF|FT		PLASMA MEMBRANE		Plasma membrane localized uracil permease; expression is tightly regulated by uracil levels and environmental cues; conformational alterations induced by unfolding or substrate binding result in Rsp5p-mediated ubiquitination and degradation	uracil transport|transmembrane transport	uracil:cation symporter activity	integral to membrane|membrane raft|plasma membrane
YBR099C_d	YBR099C	YBR099C	hom	Dubious	0.36161153745152	0.358821170856653	no	1713	0.353553670072512	1163	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene MMS4	Unknown	Unknown	Unknown
YNL050C_p	YNL050C	YNL050C	hom	Uncharacterized	0.359929213096089	0.359450035093329	no	1714	0.368317186560392	1228	NA					Putative protein of unknown function; YNL050c is not an essential gene	biological_process	molecular_function	cellular_component
YLR006C	YLR006C	SSK1	hom	Verified	0.359801269024434	0.359497877059064	no	1715	0.337124272141907	1136	NA	FT	SIGNALING|PROTEIN PHOSPHORYLATION			Cytoplasmic response regulator; part of a two-component signal transducer that mediates osmosensing via a phosphorelay mechanism; required for mitophagy; dephosphorylated form is degraded by the ubiquitin-proteasome system; potential Cdc28p substrate	activation of MAPKKK activity involved in osmosensory signaling pathway|positive regulation of protein autophosphorylation|osmosensory signaling pathway via two-component system	protein kinase activator activity|two-component response regulator activity|protein homodimerization activity|mitogen-activated protein kinase kinase kinase binding	cytoplasm
YIL089W	YIL089W	YIL089W	hom	Verified	0.357676357074366	0.360292764229113	no	1716	0.341504948655973	1133	NA	FT		ENDOPLASMIC RETICULUM		Protein of unknown function found in the ER and vacuole lumen; overexpression of YIL089W affects endocytic protein trafficking	biological_process	molecular_function	fungal-type vacuole lumen|integral to membrane|endoplasmic reticulum
YPL097W	YPL097W	MSY1	hom	Verified	0.357361856968375	0.360410463864967	no	1717	0.370930987971521	1229	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial tyrosyl-tRNA synthetase	mitochondrial tyrosyl-tRNA aminoacylation	tyrosine-tRNA ligase activity	mitochondrion
YLR454W_p	YLR454W	FMP27	hom	Uncharacterized	0.357168218944611	0.360482938226918	no	1718	0.355164530022451	1212	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YPL127C	YPL127C	HHO1	hom	Verified	0.357051048954855	0.360526794756073	no	1719	0.355277328414245	1191	NA	FT	CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS|CHROMOSOME		Histone H1, linker histone with roles in meiosis and sporulation; decreasing levels early in sporulation may promote meiosis, and increasing levels during sporulation facilitate compaction of spore chromatin; binds to promoters and within genes in mature spores; may be recruited by Ume6p to promoter regions, contributing to transcriptional repression outside of meiosis; suppresses DNA repair involving homologous recombination	negative regulation of DNA recombination|negative regulation of chromatin silencing|regulation of transcription, DNA-dependent	DNA binding	nucleus|nuclear nucleosome
YLR089C	YLR089C	ALT1	hom	Verified	0.354244120536671	0.361577970583892	no	1720	0.365526188135143	1201	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		Alanine transaminase (glutamic pyruvic transaminase); involved in alanine biosynthetic and catabolic processes; expression is induced in the presence of alanine; repression is mediated by Nrg1p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; paralogous gene ALT2 is catalytically inactive	alanine catabolic process|alanine biosynthetic process	L-alanine:2-oxoglutarate aminotransferase activity	mitochondrion
YJL065C	YJL065C	DLS1	hom	Verified	0.353413101940338	0.36188938242106	no	1721	0.381550900315728	1275	NA	FT	GENE SILENCING	NUCLEUS		Subunit of ISW2/yCHRAC chromatin accessibility complex; ISW2/yCHRAC also includes Itc1p, Isw2p, and Dpb4p; involved in inheritance of telomeric silencing; DLS1 has a paralog, DPB3, that arose from the whole genome duplication	chromatin silencing at telomere	molecular_function	chromatin accessibility complex|nucleus
YDR173C	YDR173C	ARG82	hom	Verified	0.353182683966918	0.361975744329123	no	1722	0.344891671277514	1141	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|LIPID METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Inositol polyphosphate multikinase (IPMK), sequentially phosphorylates Ins(1,4,5)P3 to form Ins(1,3,4,5,6)P5; also has diphosphoinositol polyphosphate synthase activity; regulates arginine-, phosphate-, and nitrogen-responsive genes	protein stabilization|negative regulation of transcription from RNA polymerase II promoter|phosphatidylinositol phosphorylation|regulation of arginine metabolic process|inositol phosphate biosynthetic process|positive regulation of transcription from RNA polymerase II promoter	inositol-1,4,5-trisphosphate 3-kinase activity|inositol-1,4,5-trisphosphate 6-kinase activity|phosphatidylinositol 3-kinase activity|protein binding, bridging|inositol tetrakisphosphate 6-kinase activity|inositol tetrakisphosphate 3-kinase activity|inositol-1,3,4,5,6-pentakisphosphate kinase activity	nucleus
YPL161C	YPL161C	BEM4	hom	Verified	0.351759232369621	0.362509417391232	no	1723	0.435796305559555	1434	NA	FF|FT	SIGNALING|CYTOSKELETON ORGANIZATION	NUCLEUS		Protein involved in establishment of cell polarity and bud emergence; interacts with the Rho1p small GTP-binding protein and with the Rho-type GTPase Cdc42p; involved in maintenance of proper telomere length	establishment of cell polarity|Rho protein signal transduction|actin cytoskeleton organization	molecular_function	nucleus|cytoplasm
YEL020C_p	YEL020C	YEL020C	hom	Uncharacterized	0.351313478256385	0.362676592202562	no	1724	0.367196430259411	1213	NA					Protein of unknown function with low sequence identity to Pdc1p; mRNA identified as translated by ribosome profiling data	biological_process	molecular_function	cytoplasm
YPL031C	YPL031C	PHO85	hom	Verified	0.348416917977049	0.363763549425462	no	1725	0.402144355631195	1328	NA	FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|CELL CYCLE|SIGNALING|RESPONSE TO DNA DAMAGE|CELL WALL ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS|GEN. OF PRECURSOR METABOLITES A	NUCLEUS		Cyclin-dependent kinase, with ten cyclin partners; involved in regulating the cellular response to nutrient levels and environmental conditions and progression through the cell cycle	regulation of transcription involved in G1/S phase of mitotic cell cycle|negative regulation of calcium-mediated signaling|regulation of protein stability|regulation of protein localization|protein phosphorylation|response to DNA damage stimulus|negative regulation of phosphate metabolic process|fungal-type cell wall organization|regulation of establishment or maintenance of cell polarity|negative regulation of glycogen biosynthetic process|negative regulation of transcription from RNA polymerase II promoter|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of macroautophagy|negative regulation of macroautophagy	protein kinase activity|cyclin-dependent protein kinase activity	cyclin-dependent protein kinase holoenzyme complex|nucleus
YKR006C	YKR006C	MRPL13	hom	Verified	0.347589097557512	0.364074397610265	no	1726	0.356116808448933	1201	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit, not essential for mitochondrial translation	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YAR035C-A_p	YAR035C-A	YAR035C-A	hom	Uncharacterized	0.347325661016535	0.364173337318493	no	1727	0.351059365366128	1183	NA					Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; predicted to have a role in cell budding based on computational guilt by association analysis	biological_process	molecular_function	cellular_component
YGR111W_p	YGR111W	YGR111W	hom	Uncharacterized	0.346782796018417	0.364377251413857	no	1728	0.3912100708493	1285	NA	FT		NUCLEUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus	regulation of cell size	molecular_function	nucleus|cytoplasm
YOL116W	YOL116W	MSN1	hom	Verified	0.346505702574913	0.364481349660937	no	1729	0.368156520574614	1220	NA	FT	TRANSCRIPTION FROM RNA POL II|CARBOHYDRATE METABOLISM	NUCLEUS		Transcriptional activator; involved in regulation of invertase and glucoamylase expression, invasive growth and pseudohyphal differentiation, iron uptake, chromium accumulation, and response to osmotic stress; localizes to the nucleus; relative distribution to the nucleus increases upon DNA replication stress	positive regulation of transcription from RNA polymerase II promoter in response to heat stress|positive regulation of transcription from RNA polymerase II promoter in response to methylglyoxal|positive regulation of transcription from RNA polymerase II promoter in response to increased salt|Unknown|positive regulation of starch catabolic process by positive regulation of transcription from RNA polymerase II promoter|positive regulation of invasive growth in response to glucose limitation by positive regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding	nucleus
YJL191W	YJL191W	RPS14B	hom	Verified	0.346317041406735	0.364552231460252	no	1730	0.373511369577604	1243	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION	NUCLEUS	RIBOSOME	Protein component of the small (40S) ribosomal subunit; required for ribosome assembly and 20S pre-rRNA processing; mutations confer cryptopleurine resistance; homologous to mammalian ribosomal protein S14 and bacterial S11; RPS14B has a paralog, RPS14A, that arose from the whole genome duplication	cytoplasmic translation|ribosomal small subunit assembly|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome|SSU rRNA binding	small-subunit processome|cytosolic small ribosomal subunit
YML120C	YML120C	NDI1	hom	Verified	0.34246357207667	0.366001026852217	no	1731	0.352070093551552	1174	NA	FT	OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		NADH:ubiquinone oxidoreductase; transfers electrons from NADH to ubiquinone in the respiratory chain but does not pump protons, in contrast to the higher eukaryotic multisubunit respiratory complex I; phosphorylated; involved in Mn and H2O2 induced apoptosis; upon apoptotic stress, Ndip is activated in the mitochondria by N-terminal cleavage, and the truncated protein translocates to the cytoplasm to induce apoptosis; homolog of human AMID	mitochondrial electron transport, NADH to ubiquinone|NADH oxidation|chronological cell aging|positive regulation of apoptotic process	NADH dehydrogenase (ubiquinone) activity	mitochondrion|mitochondrial matrix
YKL079W	YKL079W	SMY1	hom	Verified	0.34042000254332	0.366770128694192	no	1732	0.344789957983344	1137	NA	FT	VESICLE-MEDIATED TRANSPORT	SITE OF POLARIZED GROWTH|CYTOSKELETON		Protein that interacts with Myo2p, proposed to be involved in exocytosis; N-terminal domain is related to the motor domain of kinesins	exocytosis	motor activity	incipient cellular bud site|cellular bud neck|mating projection tip|cellular bud tip
YDR101C	YDR101C	ARX1	hom	Verified	0.340198355355065	0.36685357832049	no	1733	0.377667042999236	1243	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|PROTEOLYSIS	NUCLEUS	RIBOSOME	Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex	ribosomal large subunit biogenesis	molecular_function	nucleoplasm|cytosolic large ribosomal subunit|cytoplasm
YMR031W-A_d	YMR031W-A	YMR031W-A	hom	Dubious	0.339850877047633	0.366984415720498	no	1734	0.367282183724144	1210	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays shortened telomeres; partially overlaps the uncharacterized ORF YMR031C	Unknown	Unknown	Unknown
YMR223W	YMR223W	UBP8	hom	Verified	0.339450468944528	0.367135202149145	no	1735	0.350089371059692	1164	NA	FT	CHROMATIN ORGANIZATION|PROTEOLYSIS	NUCLEUS	HISTONE ACETYLTRANSFERASE	Ubiquitin-specific protease that is a component of the SAGA (Spt-Ada-Gcn5-Acetyltransferase) acetylation complex; required for SAGA-mediated deubiquitination of histone H2B	histone H3-K4 methylation|histone deubiquitination|histone H3-K79 methylation	ubiquitin-specific protease activity|protein complex scaffold	DUBm complex|SLIK (SAGA-like) complex|SAGA complex
YKR019C	YKR019C	IRS4	hom	Verified	0.337882415411975	0.367725899764636	no	1736	0.440234532708556	1434	NA	FF|FT	LIPID METABOLISM|SIGNALING|CELL WALL ORG/BIOGENESIS|RESPONSE TO NUTRIENT LEVELS|GENE SILENCING	MITOCHONDRION		EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; IRS4 has a paralog, TAX4, that arose from the whole genome duplication	autophagy|fungal-type cell wall organization|chromatin silencing at rDNA|inositol lipid-mediated signaling|CVT pathway|cellular response to starvation	molecular_function	mitochondrion|pre-autophagosomal structure
YMR210W	YMR210W	YMR210W	hom	Verified	0.337689121069579	0.367798736903188	no	1737	0.339319593164809	1124	NA	FT	KETONE METABOLISM|LIPID METABOLISM			Putative acyltransferase with similarity to Eeb1p and Eht1p, has a minor role in medium-chain fatty acid ethyl ester biosynthesis; may be involved in lipid metabolism and detoxification	medium-chain fatty acid biosynthetic process	transferase activity, transferring acyl groups	cellular_component
YPR002W	YPR002W	PDH1	hom	Verified	0.33740044402428	0.36790752498612	no	1738	0.36338361993429	1215	NA	FT	KETONE METABOLISM	MITOCHONDRION		Mitochondrial protein that participates in respiration, induced by diauxic shift; homologous to E. coli PrpD, may take part in the conversion of 2-methylcitrate to 2-methylisocitrate	propionate metabolic process|propionate catabolic process, 2-methylcitrate cycle	2-methylcitrate dehydratase activity	mitochondrial outer membrane|mitochondrion|cytoplasm
YBL058W	YBL058W	SHP1	hom	Verified	0.336596087693673	0.368210702926637	no	1739	0.31566684872815	1055	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|MEMBRANE ORGANIZATION|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|PROTEOLYSIS|CYTOSKELETON ORGANIZATION|RESPONSE TO NUTRIENT LEVELS|GEN. OF PRECURSOR METABOLITES AND ENERGY|CHROMOSOME SEGREGATION	NUCLEUS		UBX (ubiquitin regulatory X) domain-containing protein that regulates Glc7p phosphatase activity and interacts with Cdc48p; interacts with ubiquitylated proteins in vivo and is required for degradation of a ubiquitylated model substrate	glycogen metabolic process|proteasomal ubiquitin-dependent protein catabolic process|piecemeal microautophagy of nucleus|ER-associated protein catabolic process|ascospore formation|sister chromatid biorientation|autophagic vacuole assembly	protein phosphatase type 1 regulator activity	nucleus|cytoplasm
YER020W	YER020W	GPA2	hom	Verified	0.336328485099768	0.3683115858884	no	1740	0.342300617502952	1149	NA	FT	SIGNALING|NUCLEOTIDE METABOLISM	MITOCHONDRION|PLASMA MEMBRANE		Nucleotide binding alpha subunit of the heterotrimeric G protein that interacts with the receptor Gpr1p, has signaling role in response to nutrients; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery	adenylate cyclase-activating G-protein coupled receptor signaling pathway|ascospore formation|replicative cell aging|signal transduction|glucose mediated signaling pathway|pseudohyphal growth|hexose mediated signaling|regulation of cell size	GTPase activity	mitochondrion|plasma membrane
YBR057C	YBR057C	MUM2	hom	Verified	0.335760634368249	0.368525688858797	no	1741	0.380647411803476	1272	NA	FT	CELL CYCLE			Cytoplasmic protein essential for meiotic DNA replication and sporulation; interacts with Orc2p, which is a component of the origin recognition complex	premeiotic DNA replication	molecular_function	cytoplasm
YGR205W	YGR205W	TDA10	hom	Verified	0.333778247308108	0.369273449565245	no	1742	0.34859954866764	1159	NA	FT		NUCLEUS		ATP-binding protein of unknown function; crystal structure resembles that of E.coli pantothenate kinase and other small kinases; null mutant is sensitive to expression of the top1-T722A allele	biological_process	ATP binding	nucleus|cytoplasm
YML119W_p	YML119W	YML119W	hom	Uncharacterized	0.332022029051864	0.369936312450817	no	1743	0.371835056992041	1223	NA					Putative protein of unknown function; YML119W is not an essential gene; potential Cdc28p substrate	biological_process	molecular_function	cellular_component
YLR046C_p	YLR046C	YLR046C	hom	Uncharacterized	0.331011354179214	0.370317954584976	no	1744	0.354331143240177	1183	NA					Putative membrane protein; member of the fungal lipid-translocating exporter (LTE) family of proteins; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance	biological_process	molecular_function	integral to membrane
YMR247C	YMR247C	RKR1	hom	Verified	0.330233224678609	0.370611872009445	no	1745	0.361773689267821	1207	NA	FT	CHROMATIN ORGANIZATION|PROTEOLYSIS|GENE SILENCING	NUCLEUS		RING domain E3 ubiquitin ligase; involved in the ubiquitin-mediated degradation of non-stop proteins; functional connections to chromatin modification; nuclear protein that also co-localizes with ribosomes; homolog of mouse Listerin, whose mutation has been reported to cause neurodegeneration in mice	chromatin modification|chromatin silencing at telomere|ubiquitin-dependent protein catabolic process|protein ubiquitination	ubiquitin-protein ligase activity|ribosome binding	ribosome|nucleus
YBR168W	YBR168W	PEX32	hom	Verified	0.329994596157246	0.370702022636615	no	1746	0.378363663514301	1270	NA	FT	PEROXISOME ORGANIZATION			Peroxisomal integral membrane protein, involved in negative regulation of peroxisome size; partially functionally redundant with Pex31p; genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p	peroxisome organization	molecular_function	integral to membrane|integral to peroxisomal membrane
YBR037C	YBR037C	SCO1	hom	Verified	0.32939119966206	0.370930009330723	no	1747	0.380124665394642	1252	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Copper-binding protein of mitochondrial inner membrane; required for cytochrome c oxidase activity and respiration; may function to deliver copper to cytochrome c oxidase; similar to thioredoxins; SCO1 has a paralog, SCO2, that arose from the whole genome duplication	copper ion transport|response to redox state|protein complex assembly	copper ion binding|thioredoxin peroxidase activity	mitochondrion|mitochondrial inner membrane
YEL042W	YEL042W	GDA1	hom	Verified	0.328757095430129	0.371169647438041	no	1748	0.371308728133329	1228	NA	FT	CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Guanosine diphosphatase located in the Golgi, involved in the transport of GDP-mannose into the Golgi lumen by converting GDP to GMP after mannose is transferred its substrate	protein glycosylation	guanosine-diphosphatase activity|uridine-diphosphatase activity	Golgi apparatus
YBR010W	YBR010W	HHT1	hom	Verified	0.327901213591828	0.371493178054242	no	1749	0.383105209397031	1290	NA	FT	CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Histone H3, core histone protein required for chromatin assembly, part of heterochromatin-mediated telomeric and HM silencing; one of two identical histone H3 proteins (see HHT2); regulated by acetylation, methylation, and phosphorylation	chromatin assembly or disassembly|global genome nucleotide-excision repair|rRNA transcription|sexual sporulation resulting in formation of a cellular spore|mitotic cell cycle spindle assembly checkpoint	DNA binding	replication fork protection complex|nucleus|nuclear nucleosome
YLR220W	YLR220W	CCC1	hom	Verified	0.326906098509061	0.371869454177599	no	1750	0.366438828845301	1219	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Putative vacuolar Fe2+/Mn2+ transporter; suppresses respiratory deficit of yfh1 mutants, which lack the ortholog of mammalian frataxin, by preventing mitochondrial iron accumulation; relative distribution to the vacuole decreases upon DNA replication stress	manganese ion transport|cellular calcium ion homeostasis|cellular iron ion homeostasis|cellular manganese ion homeostasis|ferrous iron transport	manganese ion transmembrane transporter activity|ferrous iron transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane|Golgi apparatus
YFL063W_d	YFL063W	YFL063W	hom	Dubious	0.326207704888216	0.37213360615623	no	1751	0.33834534171937	1145	NA					Dubious open reading frame, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YMR304W	YMR304W	UBP15	hom	Verified	0.325108996858618	0.372549290004428	no	1752	0.394042136670773	1298	NA	FT	PROTEOLYSIS			Ubiquitin-specific protease involved in protein deubiquitination; catalytic activity regulated by an N-terminal TRAF-like domain and and C-terminal sequences; physically interacts with anaphase-promoting complex/cyclosome (APC/C) activator, Cdh1p; forms a complex with AAA peroxins Pex1p and Pex6p	protein deubiquitination	ubiquitin-specific protease activity	peroxisome|cytoplasm
YJL062W-A	YJL062W-A	COA3	hom	Verified	0.324765803295146	0.372679163896468	no	1753	0.367121260756811	1249	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial inner membrane protein that participates in regulation of COX1 translation, Cox1p stabilization, and cytochrome oxidase assembly	mitochondrial respiratory chain complex IV assembly|negative regulation of mitochondrial translation	molecular_function	mitochondrion|mitochondrial inner membrane|integral to mitochondrial inner membrane
YGL164C	YGL164C	YRB30	hom	Verified	0.324691704486594	0.372707206826124	no	1754	0.373642453698409	1222	NA	FT	PROTEIN LOCALIZATION	NUCLEUS		RanGTP-binding protein, inhibits RanGAP1 (Rna1p)-mediated GTP hydrolysis of RanGTP (Gsp1p); shares similarity to proteins in other fungi but not in higher eukaryotes	biological_process	GTPase regulator activity	nucleus|cytoplasm
YLR113W	YLR113W	HOG1	hom	Verified	0.324300897573681	0.372855120104567	no	1755	0.401490352279707	1327	NA	FT	TRANSCRIPTION FROM RNA POL II|SIGNALING|PROTEIN PHOSPHORYLATION	NUCLEUS		Mitogen-activated protein kinase involved in osmoregulation; controls global reallocation of RNA Pol II in response to osmotic shock; acts via three independent osmosensors; mitophagy-specific regulator; mediates the recruitment and activation of RNA Pol II at Hot1p-dependent promoters; localization regulated by Ptp2p and Ptp3p; protein abundance increases in response to DNA replication stress	negative regulation of transcription from RNA polymerase II promoter by pheromones|protein phosphorylation|hyperosmotic response|response to arsenic-containing substance|osmosensory signaling pathway|positive regulation of transcription from RNA polymerase II promoter|cellular response to heat	MAP kinase activity	nucleus|cytoplasm
YNL133C	YNL133C	FYV6	hom	Verified	0.324227601068917	0.372882863581267	no	1756	0.394630178464071	1305	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Protein of unknown function, required for survival upon exposure to K1 killer toxin; proposed to regulate double-strand break repair via non-homologous end-joining	double-strand break repair via nonhomologous end joining	molecular_function	nucleus
YGR096W	YGR096W	TPC1	hom	Verified	0.32422055908675	0.372885529078257	no	1757	0.409189961983252	1351	NA	FT		MITOCHONDRION		Mitochondrial membrane transporter that mediates uptake of the essential cofactor thiamine pyrophosphate (ThPP) into mitochondria; expression appears to be regulated by carbon source; member of the mitochondrial carrier family	thiamine pyrophosphate transport	thiamine transmembrane transporter activity	integral to membrane|integral to mitochondrial inner membrane
YLR394W	YLR394W	CST9	hom	Verified	0.323848547158045	0.373026349881905	no	1758	0.378063691694763	1232	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		SUMO E3 ligase; required for synaptonemal complex formation; localizes to synapsis initiation sites on meiotic chromosomes; potential Cdc28p substrate	synaptonemal complex assembly|protein sumoylation|synapsis|reciprocal meiotic recombination	SUMO ligase activity	condensed nuclear chromosome|nuclear chromosome
YLR425W	YLR425W	TUS1	hom	Verified	0.322450447025309	0.373555736038944	no	1759	0.438946412267211	1440	NA	FT	SIGNALING|CELL WALL ORG/BIOGENESIS	SITE OF POLARIZED GROWTH		Guanine nucleotide exchange factor (GEF) that modulate Rho1p activity; involved in the cell integrity signaling pathway; interacts with Rgl1p; localization of Tus1p to the bed neck is regulated by Rgl1p; multicopy suppressor of tor2 mutation and ypk1 ypk2 double mutation; potential Cdc28p substrate	fungal-type cell wall organization|signal transduction	Rho guanyl-nucleotide exchange factor activity	incipient cellular bud site|cellular bud neck
YER106W	YER106W	MAM1	hom	Verified	0.321408507381347	0.373950418454191	no	1760	0.367788268139868	1251	NA	FT	CELL CYCLE|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME	KINETOCHORE	Monopolin, kinetochore associated protein involved in chromosome attachment to meiotic spindle	meiotic chromosome segregation|meiotic sister chromatid cohesion involved in meiosis I	molecular_function	condensed nuclear chromosome kinetochore|monopolin complex
YGR180C	YGR180C	RNR4	hom	Verified	0.321301061749857	0.37399112593925	no	1761	0.40555817822227	1315	NA	FT	OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM	NUCLEUS		Ribonucleotide-diphosphate reductase (RNR) small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits; relocalizes from nucleus to cytoplasm upon DNA replication stress	cofactor biosynthetic process|deoxyribonucleotide biosynthetic process	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	ribonucleoside-diphosphate reductase complex|nucleus|cytoplasm
YMR224C	YMR224C	MRE11	hom	Verified	0.320895355858732	0.374144846731848	no	1762	0.383060224947118	1282	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS|MITOCHONDRION		Subunit of the MRX complex with Rad50p and Xrs2p; complex functions in repair of DNA double-strand breaks and in telomere stability; exhibits nuclease activity that appears to be required for MRX function; widely conserved; forms nuclear foci upon DNA replication stress	DNA repair|meiotic DNA double-strand break formation|double-strand break repair via nonhomologous end joining|base-excision repair|ascospore formation|meiotic DNA double-strand break processing|double-strand break repair via break-induced replication|regulation of transcription during meiosis	3'-5' exonuclease activity|protein complex scaffold|double-stranded telomeric DNA binding|adenylate kinase activity|telomeric DNA binding|single-stranded telomeric DNA binding|endodeoxyribonuclease activity|G-quadruplex DNA binding|endonuclease activity	mitochondrion|nucleus|Mre11 complex
YBR161W	YBR161W	CSH1	hom	Verified	0.319783155509989	0.374566358808859	no	1763	0.35695006874229	1207	NA	FT	LIPID METABOLISM			Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit; forms a complex with regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Sur1p; CSH1 has a paralog, SUR1, that arose from the whole genome duplication	glycosphingolipid biosynthetic process|sphingolipid biosynthetic process	mannosyltransferase activity|transferase activity, transferring glycosyl groups	integral to membrane|fungal-type vacuole
YMR193C-A_d	YMR193C-A	YMR193C-A	hom	Dubious	0.319004423683954	0.374861579145131	no	1764	0.350355624148907	1157	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YPR039W_d	YPR039W	YPR039W	hom	Dubious	0.317099976923332	0.375583871196881	no	1765	0.388997759416515	1296	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified non essential genes ERV2/YPR037C and TIP41/YPR040W	Unknown	Unknown	Unknown
YDR031W	YDR031W	MIC14	hom	Verified	0.316950705164404	0.375640503381851	no	1766	0.36261832264386	1164	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS|MITOCHONDRION		Mitochondrial intermembrane space protein of unknown function; required for normal oxygen consumption; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress	aerobic respiration	molecular_function	nucleus|mitochondrial intermembrane space|cytoplasm
YBR232C_d	YBR232C	YBR232C	hom	Dubious	0.316446070841156	0.375831976337976	no	1767	0.372421445242504	1253	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YOR220W	YOR220W	RCN2	hom	Verified	0.315351762793928	0.376247293669049	no	1768	0.371205292020083	1258	NA					Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; phosphorylated in response to alpha factor; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	cytoplasm
YPR052C	YPR052C	NHP6A	hom	Verified	0.315189422007848	0.376308918287205	no	1769	0.369824165362421	1219	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		High-mobility group (HMG) protein, binds to and remodels nucleosomes; involved in recruiting FACT and other chromatin remodelling complexes to chromosomes; functionally redundant with Nhp6Bp; homologous to mammalian HMGB1 and HMGB2; NHP6A has a paralog, NHP6B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress	mismatch repair|DNA replication-independent nucleosome organization|RNA polymerase II transcriptional preinitiation complex assembly|RNA polymerase III transcriptional preinitiation complex assembly|chromatin remodeling	nucleosome binding|sequence-specific DNA binding|DNA binding, bending	MutSalpha complex|nucleus
YIL131C	YIL131C	FKH1	hom	Verified	0.314816948655887	0.376450321214447	no	1770	0.377224391981747	1251	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|RNA PROCESSING|CHROMATIN ORGANIZATION|MITOCHONDRION ORGANIZATION|GENE SILENCING	NUCLEUS|CHROMOSOME		Forkhead family transcription factor; has a minor role in the expression of G2/M phase genes; negatively regulates transcriptional elongation; positive role in chromatin silencing at HML and HMR; binds to the recombination enhancer near HML, and regulates donor preference during mating-type switching by positioning HML near the MAT locus through FHA-domain mediated interactions with proteins near the DSB; FKH1 has a paralog, FKH2, that arose from the whole genome duplication	mRNA 3'-end processing|termination of RNA polymerase II transcription|donor selection|negative regulation of transcription involved in G1 phase of mitotic cell cycle|positive regulation of transcription involved in G2/M-phase of mitotic cell cycle|cellular response to methylmercury|positive regulation of chromatin silencing at silent mating-type cassette|negative regulation of transcription elongation from RNA polymerase II promoter|Unknown|negative regulation of transcription involved in G2/M-phase of mitotic cell cycle|chromatin remodeling	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|centromeric DNA binding	nucleus
YMR265C_p	YMR265C	YMR265C	hom	Uncharacterized	0.31441730999425	0.376602055411231	no	1771	0.371571094861383	1237	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YJL096W	YJL096W	MRPL49	hom	Verified	0.314110072596621	0.376718719802283	no	1772	0.389547606939064	1277	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YKL090W	YKL090W	CUE2	hom	Verified	0.314095257465125	0.376724345698605	no	1773	0.368738767498914	1196	NA					Protein of unknown function; has two CUE domains that bind ubiquitin, which may facilitate intramolecular monoubiquitination	biological_process	ubiquitin binding	cellular_component
YDR215C_d	YDR215C	YDR215C	hom	Dubious	0.313944127790038	0.376781737159419	no	1774	0.381145749884437	1250	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays elevated sensitivity to expression of a mutant huntingtin fragment or of alpha-synuclein	Unknown	Unknown	Unknown
YPL220W	YPL220W	RPL1A	hom	Verified	0.313645152062735	0.376895281146807	no	1775	0.368395163055286	1246	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L1A; N-terminally acetylated; homologous to mammalian ribosomal protein L10A and bacterial L1; RPL1A has a paralog, RPL1B, that arose from the whole genome duplication; rpl1a rpl1b double null mutation is lethal	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YPL084W	YPL084W	BRO1	hom	Verified	0.312604845301353	0.377290448243571	no	1776	0.384417746147537	1273	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEOLYSIS|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS			Cytoplasmic class E vacuolar protein sorting (VPS) factor that coordinates deubiquitination in the multivesicular body (MVB) pathway by recruiting Doa4p to endosomes	protein deubiquitination|vacuolar transport|protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|response to nutrient|ubiquitin-dependent protein catabolic process	ubiquitin-specific protease activity	endosome|cytoplasm
YCR033W	YCR033W	SNT1	hom	Verified	0.31231249787493	0.377401521412576	no	1777	0.377057128502547	1267	NA	FT	CELL CYCLE|CHROMATIN ORGANIZATION|SIGNALING	NUCLEUS|CHROMOSOME		Subunit of the Set3C deacetylase complex that interacts directly with the Set3C subunit, Sif2p; putative DNA-binding protein; mutant has increased aneuploidy tolerance	negative regulation of meiosis|regulation of transcription, DNA-dependent|histone deacetylation|positive regulation of stress-activated MAPK cascade	molecular_function	Rpd3L-Expanded complex|Set3 complex
YLR174W	YLR174W	IDP2	hom	Verified	0.312157827877429	0.377460290139966	no	1778	0.360982333246846	1229	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM			Cytosolic NADP-specific isocitrate dehydrogenase; catalyzes oxidation of isocitrate to alpha-ketoglutarate; levels are elevated during growth on non-fermentable carbon sources and reduced during growth on glucose; IDP2 has a paralog, IDP3, that arose from the whole genome duplication	glutamate biosynthetic process|isocitrate metabolic process	isocitrate dehydrogenase (NADP+) activity	cytosol
YNR040W_p	YNR040W	YNR040W	hom	Uncharacterized	0.311516510829638	0.377703996532198	no	1779	0.381855148848724	1239	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YNL305C	YNL305C	BXI1	hom	Verified	0.311418145612537	0.377741380531061	no	1780	0.355386412979874	1171	NA	FT	SIGNALING	ENDOPLASMIC RETICULUM|MITOCHONDRION		Protein involved in apoptosis; variously described as containing a BCL-2 homology (BH3) domain or as a member of the BAX inhibitor family; reported to promote apoptosis under some conditions and to inhibit it in others; localizes to ER and vacuole; may link the unfolded protein response to apoptosis via regulation of calcium-mediated signaling; translocates to mitochondria under apoptosis-inducing conditions in a process involving Mir1p and Cor1p	endoplasmic reticulum unfolded protein response|apoptotic process|calcium-mediated signaling	molecular_function	mitochondrion|integral to membrane|endoplasmic reticulum|fungal-type vacuole
YIL065C	YIL065C	FIS1	hom	Verified	0.310404746562842	0.378126592526323	no	1781	0.372287156471927	1230	NA	FT	MITOCHONDRION ORGANIZATION|PEROXISOME ORGANIZATION	MITOCHONDRION		Protein involved in mitochondrial membrane fission and peroxisome abundance; required for localization of Dnm1p and Mdv1p during mitochondrial division; mediates ethanol-induced apoptosis and ethanol-induced mitochondrial fragmentation	peroxisome fission|mitochondrial fission|chronological cell aging|peroxisome organization	molecular_function	mitochondrial outer membrane|mitochondrion|peroxisome
YPR026W	YPR026W	ATH1	hom	Verified	0.307412901801848	0.379264554559817	no	1782	0.363796925635077	1201	NA	FT	CARBOHYDRATE METABOLISM			Acid trehalase required for utilization of extracellular trehalose	trehalose catabolic process|response to stress	alpha,alpha-trehalase activity	fungal-type cell wall|cell wall-bounded periplasmic space|fungal-type vacuole
YMR001C-A_p	YMR001C-A	YMR001C-A	hom	Uncharacterized	0.30695111215306	0.379440291909277	no	1783	0.37351721722683	1221	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YBL086C_p	YBL086C	YBL086C	hom	Uncharacterized	0.306357672061216	0.379666166347978	no	1784	0.367894376644102	1243	NA					Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery	biological_process	molecular_function	cellular_component
YHR116W	YHR116W	COX23	hom	Verified	0.306338729845301	0.379673376787678	no	1785	0.382639092714563	1264	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial intermembrane space protein that functions in mitochondrial copper homeostasis, essential for functional cytochrome oxidase expression; homologous to Cox17p; contains twin cysteine-x9-cysteine motifs	mitochondrial respiratory chain complex assembly	molecular_function	mitochondrion|cytoplasm
YGR163W	YGR163W	GTR2	hom	Verified	0.305880723739201	0.379847731603196	no	1786	0.403891280736283	1328	NA	FF|FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|MEMBRANE ORGANIZATION	NUCLEUS|CHROMOSOME		Putative GTP binding protein that negatively regulates Ran/Tc4 GTPase cycle; activates transcription; subunit of EGO and GSE complexes; required for sorting of Gap1p; localizes to cytoplasm and to chromatin; homolog of human RagC and RagD	microautophagy|positive regulation of transcription from RNA polymerase II promoter	GTP binding	nuclear chromatin|fungal-type vacuole membrane|integral to membrane|EGO complex|nucleus|late endosome membrane|cytoplasm
YKL109W	YKL109W	HAP4	hom	Verified	0.305871725886081	0.379851157171346	no	1787	0.377013896401435	1250	NA	FT	TRANSCRIPTION FROM RNA POL II|OXIDATION-REDUCTION PROCESS|RESPONSE TO NUTRIENT LEVELS|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS		Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex	regulation of cellular respiration|carbon catabolite activation of transcription from RNA polymerase II promoter	RNA polymerase II activating transcription factor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II transcription factor binding transcription factor activity	CCAAT-binding factor complex
YGL215W	YGL215W	CLG1	hom	Verified	0.30522419233711	0.380097704081093	no	1788	0.393378189638321	1283	NA	FT	CELL CYCLE|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS			Cyclin-like protein that interacts with Pho85p; has sequence similarity to G1 cyclins PCL1 and PCL2	positive regulation of macroautophagy	cyclin-dependent protein kinase regulator activity	cyclin-dependent protein kinase holoenzyme complex
YGL229C	YGL229C	SAP4	hom	Verified	0.303452566354716	0.380772495383577	no	1789	0.387879031139287	1248	NA	FT	CELL CYCLE	MITOCHONDRION		Protein required for function of the Sit4p protein phosphatase, member of a family of similar proteins that form complexes with Sit4p, including Sap155p, Sap185p, and Sap190p	G1/S transition of mitotic cell cycle	protein serine/threonine phosphatase activity	mitochondrion|cytoplasm
YKR057W	YKR057W	RPS21A	hom	Verified	0.303025516088652	0.380935208109335	no	1790	0.368879304600637	1234	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21A has a paralog, RPS21B, that arose from the whole genome duplication	cytoplasmic translation|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome	cytosolic small ribosomal subunit
YBR249C	YBR249C	ARO4	hom	Verified	0.302739295722063	0.381044274263216	no	1791	0.3788204285087	1251	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase; catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by tyrosine or high concentrations of phenylalanine or tryptophan; relative distribution to the nucleus increases upon DNA replication stress	aromatic amino acid family biosynthetic process	3-deoxy-7-phosphoheptulonate synthase activity	nucleus|cytoplasm
YHL006C	YHL006C	SHU1	hom	Verified	0.302581833447219	0.381104280329507	no	1792	0.339520698357607	1186	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function	recombinational repair|maintenance of rDNA	molecular_function	nucleolus|Shu complex
YHR041C	YHR041C	SRB2	hom	Verified	0.299371771510662	0.382328199066271	no	1793	0.422746680750119	1369	NA	FT	TRANSCRIPTION FROM RNA POL II|RIBOSOME BIOGENESIS|RESPONSE TO NUTRIENT LEVELS	NUCLEUS	RNA POL II, HOLOENZYME	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; general transcription factor involved in telomere maintenance	negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter in response to chemical stimulus|RNA polymerase II transcriptional preinitiation complex assembly|negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter in response to nutrient levels|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly|core RNA polymerase II binding transcription factor activity|RNA polymerase II transcription factor recruiting transcription factor activity|TBP-class protein binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly|protein domain specific binding	core mediator complex
YGL261C_p	YGL261C	PAU11	hom	Uncharacterized	0.299245552847001	0.382376347300114	no	1794	0.38507923431751	1264	NA					Putative protein of unknown function and member of the seripauperin multigene family encoded mainly in subtelomeric regions; mRNA expression appears to be regulated by SUT1 and UPC2	biological_process	molecular_function	cellular_component
YDL021W	YDL021W	GPM2	hom	Verified	0.297987335626562	0.382856414747751	no	1795	0.390088844802058	1284	NA	FT	CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY			Homolog of Gpm1p phosphoglycerate mutase, which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event	biological_process	phosphoglycerate mutase activity|molecular_function	cytosol|cytoplasm
YOR363C	YOR363C	PIP2	hom	Verified	0.297888892373588	0.38289398295635	no	1796	0.370180614782218	1215	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS	NUCLEUS		Autoregulatory oleate-specific transcriptional activator of peroxisome proliferation, contains Zn(2)-Cys(6) cluster domain, forms heterodimer with Oaf1p, binds oleate response elements (OREs), activates beta-oxidation genes; PIP2 has a paralog, OAF1, that arose from the whole genome duplication	cellular response to oleic acid|positive regulation of fatty acid beta-oxidation|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	integral to membrane|nucleus
YBR267W	YBR267W	REI1	hom	Verified	0.297387434540894	0.383085367886405	no	1797	0.374067408354312	1266	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RIBOSOME BIOGENESIS|CELL DIVISION		RIBOSOME	Cytoplasmic pre-60S factor; required for the correct recycling of shuttling factors Alb1, Arx1 and Tif6 at the end of the ribosomal large subunit biogenesis; involved in bud growth in the mitotic signaling network	ribosomal large subunit biogenesis|nucleocytoplasmic transport|mitotic cell cycle|budding cell bud growth	sequence-specific DNA binding	cytosolic large ribosomal subunit|preribosome, large subunit precursor|cytoplasm
YIL012W_d	YIL012W	YIL012W	hom	Dubious	0.296865283668281	0.383284680794826	no	1798	0.386194401070105	1284	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YIL002W-A_p	YIL002W-A	YIL002W-A	hom	Uncharacterized	0.296611044416456	0.383381738961512	no	1799	0.35977663105156	1202	NA					Putative protein of unknown function; identified by expression profiling and mass spectrometry	biological_process	molecular_function	cellular_component
YMR273C	YMR273C	ZDS1	hom	Verified	0.296601407951298	0.383385417914496	no	1800	0.400806047986407	1347	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|CELL WALL ORG/BIOGENESIS|RNA LOCALIZATION|GENE SILENCING	ENDOMEMBRANE SYSTEM|NUCLEUS|SITE OF POLARIZED GROWTH	NUCLEAR PORE	Protein with a role in regulating Swe1p-dependent polarized growth; involved in maintaining Cdc55p in the cytoplasm where it promotes mitotic entry; involved in mitotic exit through Cdc14p regulation; interacts with silencing proteins at telomeres; has a role in Bcy1p localization; implicated in mRNA nuclear export; ZDS1 has a paralog, ZDS2, that arose from the whole genome duplication	mRNA export from nucleus|positive regulation of G2/M transition of mitotic cell cycle|cell shape checkpoint|chromatin silencing|establishment of cell polarity|regulation of protein localization|cell aging	protein phosphatase type 2A regulator activity	incipient cellular bud site|nuclear pore|cellular bud neck|cellular bud tip|cytoplasm
YOR214C_p	YOR214C	YOR214C	hom	Uncharacterized	0.296344229495111	0.383483605876776	no	1801	0.386559871921954	1271	NA					Putative protein of unknown function; YOR214C is not an essential gene	biological_process	molecular_function	fungal-type cell wall
YPL009C	YPL009C	TAE2	hom	Verified	0.296213343507191	0.383533579609882	no	1802	0.38661710212032	1276	NA	FT	TRANSLATION			Protein of unknown function, involved in protein translation; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	cytoplasmic translation	molecular_function	ribosome|cytoplasm
YDR078C	YDR078C	SHU2	hom	Verified	0.295729182495039	0.383718454529225	no	1803	0.388138411125407	1295	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function	recombinational repair|maintenance of rDNA|error-free translesion synthesis	molecular_function	Shu complex
YOR376W_d	YOR376W	YOR376W	hom	Dubious	0.294926806374132	0.384024896867104	no	1804	0.375089915677474	1229	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YOR376W is not an essential gene.	Unknown	Unknown	Unknown
YBR200W	YBR200W	BEM1	hom	Verified	0.293977995385659	0.384387358973215	no	1805	0.363009490379704	1235	NA	FT		SITE OF POLARIZED GROWTH|CYTOSKELETON		Protein containing SH3-domains, involved in establishing cell polarity and morphogenesis; functions as a scaffold protein for complexes that include Cdc24p, Ste5p, Ste20p, and Rsr1p	establishment of cell polarity|cell morphogenesis involved in conjugation with cellular fusion	protein complex scaffold|phosphatidylinositol-3-phosphate binding	incipient cellular bud site|mating projection tip|cellular bud neck|cellular bud tip
YNL084C	YNL084C	END3	hom	Verified	0.293824417990834	0.384446037693639	no	1806	0.402596390902646	1342	NA	FF|FT	VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS|CELL DIVISION|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON		EH domain-containing protein involved in endocytosis, actin cytoskeletal organization and cell wall morphogenesis; forms a complex with Sla1p and Pan1p	bipolar cellular bud site selection|ascospore wall assembly|endocytosis|actin filament organization|cytokinesis|actin cortical patch assembly	protein binding, bridging	mating projection tip|actin cortical patch
YDR515W	YDR515W	SLF1	hom	Verified	0.29342798505484	0.384597518689085	no	1807	0.391603824385565	1274	NA	FT	TRANSLATION|ION HOMEOSTASIS|ION HOMEOSTASIS			RNA binding protein that associates with polysomes; may be involved in regulating mRNA translation; involved in the copper-dependent mineralization of copper sulfide complexes on cell surface in cells cultured in copper salts; SLF1 has a paralog, SRO9, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress	cellular copper ion homeostasis|regulation of translation	RNA binding	polysome|cytoplasm
YOL001W	YOL001W	PHO80	hom	Verified	0.292881804790427	0.384806248497956	no	1808	0.401623672986637	1335	NA	FF|FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|CELL CYCLE|SIGNALING|ION HOMEOSTASIS|PROTEIN PHOSPHORYLATION|ION HOMEOSTASIS|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Cyclin, interacts with cyclin-dependent kinase Pho85p; regulates the response to nutrient levels and environmental conditions, including the response to phosphate limitation and stress-dependent calcium signaling	negative regulation of phosphate metabolic process|regulation of cyclin-dependent protein kinase activity|negative regulation of calcium-mediated signaling|negative regulation of transcription from RNA polymerase II promoter|cellular metal ion homeostasis|regulation of protein localization|negative regulation of macroautophagy	cyclin-dependent protein kinase regulator activity	cyclin-dependent protein kinase holoenzyme complex|nucleus
YHR132C	YHR132C	ECM14	hom	Verified	0.292875906272972	0.384808502874585	no	1809	0.377853353668998	1271	NA	FT	CELL WALL ORG/BIOGENESIS|PROTEOLYSIS			Putative metalloprotease with similarity to the zinc carboxypeptidase family, required for normal cell wall assembly	fungal-type cell wall organization|proteolysis	metalloendopeptidase activity	fungal-type vacuole
YKL084W	YKL084W	HOT13	hom	Verified	0.292829389256629	0.38482628152493	no	1810	0.380584600688619	1289	NA	FT	PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Zinc-binding mitochondrial intermembrane space (IMS) protein involved in a disulfide relay system for IMS import of cysteine-containing proteins; binds Mia40p and stimulates its Erv1p-dependent oxidation, probably by sequestering zinc	protein import into mitochondrial intermembrane space	zinc ion binding	mitochondrial intermembrane space
YEL054C	YEL054C	RPL12A	hom	Verified	0.292748081488852	0.384857357667391	no	1811	0.374147137477789	1254	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L12A; rpl12a rpl12b double mutant exhibits slow growth and slow translation; homologous to mammalian ribosomal protein L12 and bacterial L11; RPL12A has a paralog, RPL12B, that arose from the whole genome duplication	cytoplasmic translation|ribosomal large subunit assembly	structural constituent of ribosome	cytosolic large ribosomal subunit
YKR040C_d	YKR040C	YKR040C	hom	Dubious	0.29274193984781	0.384859705056336	no	1812	0.382197732670773	1265	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YKR041W	Unknown	Unknown	Unknown
YNL294C	YNL294C	RIM21	hom	Verified	0.292455321242585	0.384969257888093	no	1813	0.394724684784902	1316	NA	FF|FT	ION HOMEOSTASIS|CELL WALL ORG/BIOGENESIS|ION HOMEOSTASIS	PLASMA MEMBRANE		pH sensor molecule, component of the RIM101 pathway; has a role in cell wall construction and alkaline pH response; is glycosylated and phosphorylated; interacts with Dfg16p and Rim9p to form a pH-sensing complex; localization to the plasma membrane is dependent on Dfg16p and Rim9p; has similarity to A. nidulans PalH	fungal-type cell wall biogenesis|ascospore formation|invasive growth in response to glucose limitation	molecular_function	integral to membrane
YPL067C_p	YPL067C	YPL067C	hom	Uncharacterized	0.291380342856706	0.385380223378743	no	1814	0.372954716576175	1220	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YPL067C is not an essential gene	biological_process	molecular_function	cytoplasm
YPL221W	YPL221W	FLC1	hom	Verified	0.290877676263155	0.385572437606868	no	1815	0.382412497591506	1249	NA	FT	CELL WALL ORG/BIOGENESIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|SITE OF POLARIZED GROWTH		Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance	protein folding|fungal-type cell wall biogenesis|FAD transport	FAD transmembrane transporter activity	integral to membrane|endoplasmic reticulum|fungal-type vacuole|cellular bud neck
YGL002W	YGL002W	ERP6	hom	Verified	0.289984103202706	0.385914199571731	no	1816	0.406254486666529	1346	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION		Member of the p24 family involved in ER to Golgi transport; similar to Emp24p and Erv25p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; ERP6 has a paralog, ERP1, that arose from the whole genome duplication	ER to Golgi vesicle-mediated transport	molecular_function	mitochondrion|integral to membrane
YML060W	YML060W	OGG1	hom	Verified	0.289280253525969	0.386183461025458	no	1817	0.385416236472247	1267	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS|MITOCHONDRION		Mitochondrial glycosylase/lyase that specifically excises 7,8-dihydro-8-oxoguanine residues located opposite cytosine or thymine residues in DNA, repairs oxidative damage to mitochondrial DNA, contributes to UVA resistance	DNA repair|base-excision repair, AP site formation	oxidized purine nucleobase lesion DNA N-glycosylase activity	mitochondrion
YML037C_p	YML037C	YML037C	hom	Uncharacterized	0.287013550602627	0.387050972336035	no	1818	0.400888306838976	1321	NA					Putative protein of unknown function with some characteristics of a transcriptional activator; may be a target of Dbf2p-Mob1p kinase; GFP-fusion protein co-localizes with clathrin-coated vesicles; YML037C is not an essential gene	biological_process	molecular_function	clathrin-coated vesicle
YML084W_d	YML084W	YML084W	hom	Dubious	0.286970132856887	0.387067594675701	no	1819	0.365625108399197	1232	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDR275W	YDR275W	BSC2	hom	Verified	0.286535798138842	0.387233889673199	no	1820	0.397352051981283	1319	NA					Protein of unknown function; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; BSC2 has a paralog, IRC23, that arose from the whole genome duplication	biological_process	molecular_function	lipid particle
YER076C_p	YER076C	YER076C	hom	Uncharacterized	0.286297953087515	0.387324962872229	no	1821	0.385832168037099	1276	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; analysis of HA-tagged protein suggests a membrane localization	biological_process	molecular_function	mitochondrion
YKL087C	YKL087C	CYT2	hom	Verified	0.286014740419405	0.387433415864612	no	1822	0.387600348367553	1280	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS	MITOCHONDRION		Cytochrome c1 heme lyase, involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1	cytochrome c-heme linkage	holocytochrome-c synthase activity	mitochondrion|mitochondrial intermembrane space
YGL007C-A_p	YGL007C-A	YGL007C-A	hom	Uncharacterized	0.28534706672346	0.38768912848453	no	1823	0.385795203851818	1265	NA					Putative protein of unknown function, identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; deletion exhibits slow-growth phenotype; computationally predicted to have a role in cell budding	biological_process	molecular_function	cellular_component
YNL293W	YNL293W	MSB3	hom	Verified	0.284897865939799	0.387861195498339	no	1824	0.383224227739984	1266	NA	FT	VESICLE-MEDIATED TRANSPORT|SIGNALING|NUCLEOTIDE METABOLISM|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH		Rab GTPase-activating protein; regulates endocytosis via activation of Vps21p and Ypt7p; also acts on Ypt52p and Sec4p; also required for proper actin organization; localizes to the plasma membrane and sites of polarized growth, and a portion localizes to endosomes and vacuoles; similar to Msb4p; relocalizes from bud neck to cytoplasm upon DNA replication stress	actin filament organization|exocytosis	Rab GTPase activator activity	incipient cellular bud site|polarisome|cellular bud tip
YHL021C	YHL021C	AIM17	hom	Verified	0.284355489128212	0.388068983069839	no	1825	0.382929451516881	1243	NA	FT	OXIDATION-REDUCTION PROCESS	MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays reduced frequency of mitochondrial genome loss	biological_process	molecular_function	mitochondrion
YCR076C	YCR076C	FUB1	hom	Verified	0.28391077205033	0.388239380569545	no	1826	0.430541361519924	1403	NA					Putative protein of unknown function; interacts physically with multiple subunits of the 20S proteasome and genetically with genes encoding 20S core particle and 19S regulatory particle subunits; exhibits boundary activity which blocks the propagation of heterochromatic silencing; contains a PI31 proteasome regulator domain and sequence similarity with human PSMF1, a proteasome inhibitor; not an essential gene	biological_process	proteasome binding	cellular_component
YGL006W-A_p	YGL006W-A	YGL006W-A	hom	Uncharacterized	0.283381944546168	0.388442033766235	no	1827	0.374102605399368	1263	NA					Putative protein of unknown function; identified by SAGE	biological_process	molecular_function	cellular_component
YDR263C	YDR263C	DIN7	hom	Verified	0.281759391115198	0.389064005503979	no	1828	0.398189622151628	1325	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS|MITOCHONDRION		Mitochondrial nuclease functioning in DNA repair and replication, modulates the stability of the mitochondrial genome, induced by exposure to mutagens, also induced during meiosis at a time nearly coincident with commitment to recombination	DNA repair	nuclease activity	mitochondrion
YDL086W_p	YDL086W	YDL086W	hom	Uncharacterized	0.281713057057165	0.389081770874785	no	1829	0.364682105057581	1195	NA	FT		MITOCHONDRION		Putative carboxymethylenebutenolidase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL086W is not an essential gene	biological_process	carboxymethylenebutenolidase activity	mitochondrion|cytoplasm
YJL089W	YJL089W	SIP4	hom	Verified	0.28134542301692	0.389222737067355	no	1830	0.396835124360141	1307	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		C6 zinc cluster transcriptional activator that binds to the carbon source-responsive element (CSRE) of gluconeogenic genes; involved in the positive regulation of gluconeogenesis; regulated by Snf1p protein kinase; localized to the nucleus	positive regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source|positive regulation of gluconeogenesis|positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter|Unknown	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YGL218W_d	YGL218W	YGL218W	hom	Dubious	0.279858932551604	0.389792867873588	no	1831	0.414609867637677	1346	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 93% of ORF overlaps the verified gene MDM34; deletion in cyr1 mutant results in loss of stress resistance	Unknown	Unknown	Unknown
YPL138C	YPL138C	SPP1	hom	Verified	0.279318626713966	0.39000015643893	no	1832	0.391583334341098	1317	NA	FT	CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS		Subunit of COMPASS (Set1C), a complex which methylates histone H3 on lysine 4 and is required in telomeric transcriptional silencing; interacts with Orc2p; PHD finger domain protein similar to human CGBP, an unmethylated CpG binding protein	histone H3-K4 methylation|regulation of transcription, DNA-dependent|chromatin silencing at telomere	histone methyltransferase activity (H3-K4 specific)|chromatin binding|methylated histone residue binding	Set1C/COMPASS complex
YHR046C	YHR046C	INM1	hom	Verified	0.27857947570544	0.390283782703305	no	1833	0.398353091627519	1306	NA	FT	LIPID METABOLISM|CARBOHYDRATE METABOLISM	NUCLEUS		Inositol monophosphatase, involved in biosynthesis of inositol and in phosphoinositide second messenger signaling; INM1 expression increases in the presence of inositol and decreases upon exposure to antibipolar drugs lithium and valproate	inositol phosphate dephosphorylation	inositol monophosphate 1-phosphatase activity	nucleus|cytoplasm
YDL018C	YDL018C	ERP3	hom	Verified	0.278332473210135	0.39037857527406	no	1834	0.39768542941335	1303	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport	vesicle-mediated transport	molecular_function	integral to membrane
YDR149C_d	YDR149C	YDR149C	hom	Dubious	0.27780230035196	0.390582062620046	no	1835	0.390023182410532	1306	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene NUM1; null mutation blocks anaerobic growth	Unknown	Unknown	Unknown
YHR147C	YHR147C	MRPL6	hom	Verified	0.274458034523895	0.391866324688681	no	1836	0.405986959695947	1331	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YPL098C	YPL098C	MGR2	hom	Verified	0.274356002807523	0.391905525426566	no	1837	0.419795064244599	1389	NA	FT		MITOCHONDRION		Subunit of the TIM23 translocase complex; acts to couple Tim21p with the core Tim23 translocase; absolutely required for mitochondrial import of presequence-containing proteins at elevated temperature; required for viability of cells lacking the mitochondrial genome (petite-negative phenotype)	protein import into mitochondrial matrix	molecular_function	mitochondrial inner membrane presequence translocase complex
YNL083W	YNL083W	SAL1	hom	Verified	0.273476466070122	0.392243490216858	no	1838	0.38200835650712	1289	NA	FT		MITOCHONDRION		ADP/ATP transporter; member of the Ca2+-binding subfamily of mitochondrial carriers, with two EF-hand motifs; transport activity of either Sal1p or Pet9p is critical for viability; polymorphic in different S. cerevisiae strains	ATP transport|ADP transport|mitochondrial transport	ATP:ADP antiporter activity|calcium ion binding	mitochondrion|integral to membrane|mitochondrial inner membrane
YLR414C	YLR414C	PUN1	hom	Verified	0.271539329659804	0.392988127423842	no	1839	0.35997571466508	1166	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL WALL ORG/BIOGENESIS	PLASMA MEMBRANE		Plasma membrane protein with a role in cell wall integrity; co-localizes with Sur7p in punctate membrane patches; null mutant displays decreased thermotolerance; transcription induced upon cell wall damage and metal ion stress	fungal-type cell wall organization|protein oligomerization	molecular_function	integral to membrane|membrane raft|plasma membrane|cellular bud|cytoplasm
YFR032C_p	YFR032C	RRT5	hom	Uncharacterized	0.27150441749089	0.393001551299013	no	1840	0.391382015428121	1300	NA					Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; expressed at high levels during sporulation	biological_process	molecular_function	cellular_component
YJR146W_p	YJR146W	YJR146W	hom	Uncharacterized	0.270249994602312	0.393483966459305	no	1841	0.390938208861211	1302	NA					Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps HMS2	biological_process	molecular_function	cellular_component
YNL268W	YNL268W	LYP1	hom	Verified	0.266606435928479	0.394886099898504	no	1842	0.405246849265402	1346	NA	FT		MITOCHONDRION|PLASMA MEMBRANE		Lysine permease; one of three amino acid permeases (Alp1p, Can1p, Lyp1p) responsible for uptake of cationic amino acids	basic amino acid transport	basic amino acid transmembrane transporter activity	mitochondrion|integral to membrane|plasma membrane
YPR115W	YPR115W	RGC1	hom	Verified	0.265692622757069	0.395237972714246	no	1843	0.401320057534191	1317	NA	FT	CELL CYCLE			Pleckstrin homology domain containing protein; proposed to function as a glycerol channel activator; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; RGC1 has a paralog, ASK10, that arose from the whole genome duplication	positive regulation of glycerol transport	molecular_function	cytoplasm
YGL144C	YGL144C	ROG1	hom	Verified	0.26500470136819	0.395502920047367	no	1844	0.399609606623567	1299	NA	FT	LIPID METABOLISM			Protein with putative serine active lipase domain; ROG1 has a paralog, YDL109C, that arose from the whole genome duplication	cellular lipid metabolic process	lipase activity	cellular_component
YEL007W	YEL007W	MIT1	hom	Verified	0.264827927096509	0.395571011027649	no	1845	0.378688258954685	1259	NA	FT		NUCLEUS		Transcriptional regulator of pseudohyphal growth; protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1) and C. albicans Wor1	biological_process	molecular_function	nucleus|cytoplasm
YBR205W	YBR205W	KTR3	hom	Verified	0.264449088211464	0.395716945208015	no	1846	0.380101837929082	1248	NA	FT	CARBOHYDRATE METABOLISM			Putative alpha-1,2-mannosyltransferase; involved in O- and N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; Svp26p mediates uptake of Ktr3p into COPII vesicles; relocalizes from nucleus to vacuole upon DNA replication stress	N-glycan processing|protein O-linked glycosylation	mannosyltransferase activity	fungal-type vacuole
YHR149C	YHR149C	SKG6	hom	Verified	0.264443445551148	0.39571911895238	no	1847	0.399524913700328	1317	NA	FT		SITE OF POLARIZED GROWTH		Integral membrane protein that localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p	biological_process	molecular_function	cell cortex|incipient cellular bud site|integral to membrane|cellular bud neck|cellular bud tip
YLR262C	YLR262C	YPT6	hom	Verified	0.26400382938029	0.395888483995051	no	1848	0.442357208344951	1450	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING	GOLGI APPARATUS|PLASMA MEMBRANE		Rab family GTPase, Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity to the human GTPase, Rab6	intracellular protein transport|retrograde transport, endosome to Golgi	GTPase activity	Golgi apparatus
YDL131W	YDL131W	LYS21	hom	Verified	0.263354941679027	0.39613850819414	no	1849	0.377298403932287	1254	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS|MITOCHONDRION		Homocitrate synthase isozyme; catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; LYS21 has a paralog, LYS20, that arose from the whole genome duplication	lysine biosynthetic process via aminoadipic acid	homocitrate synthase activity	nucleus
YFL055W	YFL055W	AGP3	hom	Verified	0.262449909933676	0.396487299097926	no	1850	0.400711704460487	1333	NA	FT		PLASMA MEMBRANE		Low-affinity amino acid permease, may act to supply the cell with amino acids as nitrogen source in nitrogen-poor conditions; transcription is induced under conditions of sulfur limitation; plays a role in regulating Ty1 transposition	amino acid transport|transmembrane transport	amino acid transmembrane transporter activity	integral to membrane|plasma membrane
YNL242W	YNL242W	ATG2	hom	Verified	0.262127910549243	0.396611414694328	no	1851	0.391219790295507	1284	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS|PEROXISOME ORGANIZATION			Peripheral membrane protein required for autophagic vesicle formation; also required for vesicle formation during pexophagy and the cytoplasm-to-vaucole targeting (Cvt) pathway; involved in Atg9p cycling between the phagophore assembly site and mitochondria; forms cytoplasmic foci upon DNA replication stress	mitochondrion degradation|piecemeal microautophagy of nucleus|peroxisome degradation|CVT pathway|autophagic vacuole assembly	molecular_function	pre-autophagosomal structure|cytoplasm|extrinsic to membrane
YJR100C	YJR100C	AIM25	hom	Verified	0.261880014302914	0.396706974159274	no	1852	0.383557677677934	1282	NA	FT		MITOCHONDRION		Putative protein of unknown function; non-tagged protein is detected in purified mitochondria in high-throughput studies; similar to murine NOR1; null mutant is viable and displays elevated frequency of mitochondrial genome loss	biological_process	molecular_function	mitochondrion
YMR292W	YMR292W	GOT1	hom	Verified	0.261709350815899	0.396772765415354	no	1853	0.382795964401021	1269	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Homodimeric protein that is packaged into COPII vesicles and cycles between the ER and Golgi; involved in secretory transport but not directly required for aspects of transport assayed in vitro; may influence membrane composition	ER to Golgi vesicle-mediated transport|Golgi to endosome transport	molecular_function	integral to membrane|endoplasmic reticulum|Golgi apparatus|ER to Golgi transport vesicle|Golgi membrane
YMR291W	YMR291W	TDA1	hom	Verified	0.261063202307168	0.397021884099195	no	1854	0.379281822540985	1258	NA	FT	PROTEIN PHOSPHORYLATION	NUCLEUS		Protein kinase of unknown cellular role; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; null mutant is sensitive to expression of the top1-T722A allele; not an essential gene; relocalizes from nucleus to cytoplasm upon DNA replication stress	protein phosphorylation	protein kinase activity	nucleus|cytoplasm
YGR256W	YGR256W	GND2	hom	Verified	0.25973003398882	0.397536011852021	no	1855	0.390239933682582	1329	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS			6-phosphogluconate dehydrogenase (decarboxylating); catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone; GND2 has a paralog, GND1, that arose from the whole genome duplication	pentose-phosphate shunt, oxidative branch	phosphogluconate dehydrogenase (decarboxylating) activity	cytosol|plasma membrane
YCL032W	YCL032W	STE50	hom	Verified	0.257867701272944	0.398254506340241	no	1856	0.400486343959264	1304	NA	FT	CELL CYCLE|SIGNALING			Protein involved in mating response, invasive/filamentous growth, and osmotolerance, acts as an adaptor that links G protein-associated Cdc42p-Ste20p complex to the effector Ste11p to modulate signal transduction	pheromone-dependent signal transduction involved in conjugation with cellular fusion|MAPK cascade involved in osmosensory signaling pathway|osmosensory signaling pathway via Sho1 osmosensor|signal transduction involved in filamentous growth|cellular response to heat	SAM domain binding|protein kinase regulator activity	cytoplasm
YDR480W	YDR480W	DIG2	hom	Verified	0.257829199826999	0.398269363982345	no	1857	0.385625419803464	1284	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		MAP kinase-responsive inhibitor of the Ste12p transcription factor, involved in the regulation of mating-specific genes and the invasive growth pathway; related regulators Dig1p and Dig2p bind to Ste12p	negative regulation of transcription from RNA polymerase II promoter by pheromones|Unknown	transcription factor binding	nucleus
YGL176C_p	YGL176C	YGL176C	hom	Uncharacterized	0.257398324120906	0.398435648236438	no	1858	0.406945879557474	1314	NA					Putative protein of unknown function; deletion mutant is viable and has no detectable phenotype	biological_process	molecular_function	cellular_component
YDR219C	YDR219C	MFB1	hom	Verified	0.257375828113979	0.398444330438904	no	1859	0.389705432886133	1319	NA	FT	PROTEOLYSIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION	UBIQUITIN LIGASE COMPLEX	Mitochondria-associated F-box protein involved in maintenance of normal mitochondrial morphology; interacts with Skp1p through the F-box motif; preferentially localizes to the mother cell during budding	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|mitochondrion organization	molecular_function	extrinsic to mitochondrial outer membrane|SCF ubiquitin ligase complex
YLL044W_d	YLL044W	YLL044W	hom	Dubious	0.256529592435718	0.398770966631798	no	1860	0.372109571029787	1258	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcription of both YLL044W and the overlapping gene RPL8B is reduced in the gcr1 null mutant	Unknown	Unknown	Unknown
YFL020C	YFL020C	PAU5	hom	Verified	0.256471114734527	0.398793540901666	no	1861	0.390930186722755	1286	NA					Member of the seripauperin multigene family encoded mainly in subtelomeric regions; induced during alcoholic fermentation; induced by low temperature and also by anaerobic conditions; negatively regulated by oxygen and repressed by heme	biological_process	molecular_function	integral to membrane|cytoplasm
YFR045W_p	YFR045W	YFR045W	hom	Uncharacterized	0.255658725607897	0.399107184174023	no	1862	0.375753704188732	1264	NA	FT		MITOCHONDRION		Putative mitochondrial transport protein; null mutant is viable, exhibits decreased levels of chitin and normal resistance to calcofluor white	transport	transporter activity	integral to membrane|mitochondrial inner membrane
YLR258W	YLR258W	GSY2	hom	Verified	0.255234058903324	0.399271163386539	no	1863	0.380961487020033	1237	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY			Glycogen synthase; expression induced by glucose limitation, nitrogen starvation, heat shock, and stationary phase; activity regulated by cAMP-dependent, Snf1p and Pho85p kinases as well as by the Gac1p-Glc7p phosphatase; GSY2 has a paralog, GSY1, that arose from the whole genome duplication; relocalizes from cytoplasm to plasma membrane upon DNA replication stress	glycogen biosynthetic process	glycogen (starch) synthase activity	cytoplasm
YPL139C	YPL139C	UME1	hom	Verified	0.254331818814172	0.399619609962372	no	1864	0.401780504322711	1325	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS|CHROMOSOME		Negative regulator of meiosis, required for repression of a subset of meiotic genes during vegetative growth, binding of histone deacetylase Rpd3p required for activity, contains a NEE box and a WD repeat motif; homologous with Wtm1p, Wtm2p	positive regulation of transcription from RNA polymerase II promoter in response to heat stress|negative regulation of transcription from RNA polymerase I promoter|negative regulation of chromatin silencing at telomere|positive regulation of transcription from RNA polymerase II promoter|regulation of meiosis	transcription corepressor activity	Rpd3S complex|Rpd3L-Expanded complex|nucleus|Rpd3L complex
YDL184C	YDL184C	RPL41A	hom	Verified	0.252655587881987	0.400267185137668	no	1865	0.402563563310576	1306	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L41A; comprises only 25 amino acids; rpl41a rpl41b double null mutant is viable; homologous to mammalian ribosomal protein L41, no bacterial homolog; RPL41A has a paralog, RPL41B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YDR259C	YDR259C	YAP6	hom	Verified	0.252368507802003	0.400378119810787	no	1866	0.382730271977578	1283	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Basic leucine zipper (bZIP) transcription factor; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; overexpression increases sodium and lithium tolerance; computational analysis suggests a role in regulation of expression of genes involved in carbohydrate metabolism; YAP6 has a paralog, CIN5, that arose from the whole genome duplication	negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding transcription factor recruiting transcription factor activity|sequence-specific DNA binding RNA polymerase II transcription factor activity|sequence-specific DNA binding	nucleus
YLR188W	YLR188W	MDL1	hom	Verified	0.250883523452626	0.400952081738963	no	1867	0.409117366514685	1363	NA	FT	NUCLEOTIDE METABOLISM	MITOCHONDRION		Mitochondrial inner membrane half-type ATP-binding cassette (ABC) transporter, mediates export of peptides generated upon proteolysis of mitochondrial proteins, plays a role in the regulation of cellular resistance to oxidative stress	oligopeptide transport|oligopeptide export from mitochondrion	ATPase activity|oligopeptide-transporting ATPase activity	mitochondrion|integral to membrane|mitochondrial inner membrane
YPL054W	YPL054W	LEE1	hom	Verified	0.250755208836873	0.401001686730905	no	1868	0.373299541503106	1240	NA					Zinc-finger protein of unknown function	biological_process	molecular_function	cellular_component
YGL184C	YGL184C	STR3	hom	Verified	0.249642471985679	0.40143192517661	no	1869	0.424801670136575	1411	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Peroxisomal cystathionine beta-lyase, converts cystathionine into homocysteine; may be redox regulated by Gto1p	methionine biosynthetic process|transsulfuration	cystathionine beta-lyase activity	peroxisome
YJL007C_d	YJL007C	YJL007C	hom	Dubious	0.248550260157732	0.401854343892351	no	1870	0.403684873492261	1336	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YPL034W_p	YPL034W	YPL034W	hom	Uncharacterized	0.246663184188128	0.402584450518798	no	1871	0.412572339929083	1347	NA					Putative protein of unknown function; YPL034W is not essential gene	biological_process	molecular_function	cellular_component
YPR062W	YPR062W	FCY1	hom	Verified	0.246264246218191	0.402738842580141	no	1872	0.413419181837489	1341	NA	FT		NUCLEUS		Cytosine deaminase, zinc metalloenzyme that catalyzes the hydrolytic deamination of cytosine to uracil; of biomedical interest because it also catalyzes the deamination of 5-fluorocytosine (5FC) to form anticancer drug 5-fluorouracil (5FU)	cytosine metabolic process|pyrimidine-containing compound salvage|cytidine metabolic process	cytosine deaminase activity	nucleus|cytoplasm
YLR150W	YLR150W	STM1	hom	Verified	0.246037512822779	0.402826596909165	no	1873	0.385541083931001	1279	NA	FT	SIGNALING|TRANSLATION	NUCLEUS	RIBOSOME	Protein required for optimal translation under nutrient stress; perturbs association of Yef3p with ribosomes; involved in TOR signaling; binds G4 quadruplex and purine motif triplex nucleic acid; helps maintain telomere structure; protein abundance increases in response to DNA replication stress; serves as a ribosome preservation factor both during quiescence and recovery	translational elongation|TOR signaling cascade|regulation of translational initiation in response to stress|telomere maintenance|anti-apoptosis	triplex DNA binding|DNA binding|telomeric DNA binding	cytosolic ribosome|polysome|cytoplasm
YIL077C_p	YIL077C	YIL077C	hom	Uncharacterized	0.245213541015359	0.40314554609738	no	1874	0.415253690974169	1372	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)	biological_process	molecular_function	mitochondrion
YIL121W	YIL121W	QDR2	hom	Verified	0.244349335652303	0.403480138435795	no	1875	0.391500617615561	1283	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; exports copper; has broad substrate specificity and can transport many mono- and divalent cations; transports a variety of drugs and is required for resistance to quinidine, barban, cisplatin, and bleomycin; contributes to potassium homeostasis; expression is regulated by copper	drug transmembrane transport|potassium ion import	drug transmembrane transporter activity	integral to membrane|integral to plasma membrane
YMR177W	YMR177W	MMT1	hom	Verified	0.243567296938222	0.403782979418623	no	1876	0.402402763920265	1347	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Putative metal transporter involved in mitochondrial iron accumulation; closely related to Mmt2p	cellular iron ion homeostasis	molecular_function	mitochondrion|integral to membrane
YHR049W	YHR049W	FSH1	hom	Verified	0.241254329137046	0.404679002790371	no	1877	0.383354519262797	1288	NA	FT		NUCLEUS		Putative serine hydrolase that localizes to both the nucleus and cytoplasm; sequence is similar to S. cerevisiae Fsh2p and Fsh3p and the human candidate tumor suppressor OVCA2	biological_process	hydrolase activity	nucleus|cytoplasm
YDR080W	YDR080W	VPS41	hom	Verified	0.240200392034142	0.405087454888583	no	1878	0.4044095351801	1326	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|VACUOLAR PROTEIN PROCESSING			Vacuolar membrane protein that is a subunit of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex; essential for membrane docking and fusion at the Golgi-to-endosome and endosome-to-vacuole stages of protein transport	regulation of SNARE complex assembly|regulation of vacuole fusion, non-autophagic|piecemeal microautophagy of nucleus|vacuole organization|vesicle-mediated transport|protein transport|vacuole fusion, non-autophagic|vacuolar protein processing	Rab guanyl-nucleotide exchange factor activity|phosphatidylinositol binding	endosome|fungal-type vacuole membrane|HOPS complex
YLR292C	YLR292C	SEC72	hom	Verified	0.23951600893692	0.405352742168703	no	1879	0.415091216269419	1358	NA	FT	PROTEIN LOCALIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER	posttranslational protein targeting to membrane, translocation	protein transporter activity	Sec62/Sec63 complex|endoplasmic reticulum membrane
YJR124C_p	YJR124C	YJR124C	hom	Uncharacterized	0.23929209856569	0.405439545947712	no	1880	0.384831946164825	1270	NA					Putative protein of unknown function; expression induced under calcium shortage	biological_process	molecular_function	integral to membrane
YER087C-A_d	YER087C-A	YER087C-A	hom	Dubious	0.238595664140647	0.405709563778846	no	1881	0.397464929604641	1338	NA					Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; overlaps the uncharacterized gene YER087W, a putative tRNA synthetase	Unknown	Unknown	Unknown
YIR036C_p	YIR036C	IRC24	hom	Uncharacterized	0.237953094134469	0.405958737388379	no	1882	0.407384877540639	1347	NA	FT	OXIDATION-REDUCTION PROCESS			Putative benzil reductase;(GFP)-fusion protein localizes to the cytoplasm and is induced by the DNA-damaging agent MMS; sequence similarity with short-chain dehydrogenase/reductases; null mutant has increased spontaneous Rad52p foci	biological_process	molecular_function	integral to membrane|cytoplasm
YNR039C	YNR039C	ZRG17	hom	Verified	0.23790871366288	0.405975948504356	no	1883	0.388183512430932	1279	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Msc2p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; zinc-regulated directly through Zap1p; transcription induced under conditions of zinc deficiency	zinc ion transport	zinc ion transmembrane transporter activity|metal ion transmembrane transporter activity	integral to membrane|endoplasmic reticulum
YGL007W_d	YGL007W	BRP1	hom	Dubious	0.237567693121929	0.406108205166971	no	1884	0.43495109368245	1409	NA	FF				Dubious ORF located in the upstream region of PMA1, deletion leads to polyamine resistance due to downregulation of PMA1	Unknown	Unknown	Unknown
YDR505C	YDR505C	PSP1	hom	Verified	0.236884359710644	0.406373251924035	no	1885	0.402329177327466	1334	NA	FT		MITOCHONDRION		Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication	biological_process	molecular_function	mitochondrion|cytoplasm
YOR107W	YOR107W	RGS2	hom	Verified	0.236592754709478	0.406486370774722	no	1886	0.417315313941473	1407	NA	FT	SIGNALING	NUCLEUS|PLASMA MEMBRANE		Negative regulator of glucose-induced cAMP signaling; directly activates the GTPase activity of the heterotrimeric G protein alpha subunit Gpa2p	adenylate cyclase-modulating G-protein coupled receptor signaling pathway	GTPase activator activity	nucleus|cytoplasm
YDR313C	YDR313C	PIB1	hom	Verified	0.235781620418705	0.406801065446931	no	1887	0.408485510737206	1357	NA					RING-type ubiquitin ligase of the endosomal and vacuolar membranes, binds phosphatidylinositol(3)-phosphate; contains a FYVE finger domain	protein ubiquitination	ubiquitin-protein ligase activity|phosphatidylinositol-3-phosphate binding	fungal-type vacuole membrane|late endosome
YDR426C_d	YDR426C	YDR426C	hom	Dubious	0.2336195021541	0.40764019306663	no	1888	0.396350358848977	1302	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SNX41	Unknown	Unknown	Unknown
YGR039W_d	YGR039W	YGR039W	hom	Dubious	0.231198337872902	0.408580360607241	no	1889	0.427306713796933	1436	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the Autonomously Replicating Sequence ARS722	Unknown	Unknown	Unknown
YDR540C	YDR540C	IRC4	hom	Verified	0.230436218888018	0.408876409857804	no	1890	0.426083026174339	1421	NA	FF|FT		NUCLEUS		Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus	mitotic recombination	molecular_function	nucleus|cytoplasm
YCR089W	YCR089W	FIG2	hom	Verified	0.230285622443279	0.408934916020668	no	1891	0.403206162092593	1300	NA	FT	CELL WALL ORG/BIOGENESIS			Cell wall adhesin, expressed specifically during mating; may be involved in maintenance of cell wall integrity during mating	filamentous growth of a population of unicellular organisms|cell morphogenesis involved in conjugation with cellular fusion|invasive growth in response to glucose limitation|cytogamy	molecular_function	fungal-type cell wall|mating projection
YGL087C	YGL087C	MMS2	hom	Verified	0.22983107641989	0.409111517772279	no	1892	0.407377067086346	1329	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RESPONSE TO DNA DAMAGE	NUCLEUS		Ubiquitin-conjugating enzyme variant; involved in error-free postreplication repair; forms a heteromeric complex with Ubc13p, an active ubiquitin-conjugating enzyme; cooperates with chromatin-associated RING finger proteins, Rad18p and Rad5p; protein abundance increases in response to DNA replication stress	postreplication repair|response to DNA damage stimulus|protein polyubiquitination|free ubiquitin chain polymerization	ubiquitin-protein ligase activity	ubiquitin conjugating enzyme complex|nucleus|cytoplasm
YEL056W	YEL056W	HAT2	hom	Verified	0.229171062851026	0.409367981302676	no	1893	0.397044002268492	1297	NA	FT	CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING	NUCLEUS	HISTONE ACETYLTRANSFERASE	Subunit of the Hat1p-Hat2p histone acetyltransferase complex; required for high affinity binding of the complex to free histone H4, thereby enhancing Hat1p activity; similar to human RbAp46 and 48; has a role in telomeric silencing	histone acetylation|chromatin assembly or disassembly|chromatin silencing at telomere	histone acetyltransferase activity|histone binding	histone acetyltransferase complex|nucleus|cytoplasm
YJR070C	YJR070C	LIA1	hom	Verified	0.229104211810579	0.409393959985375	no	1894	0.413509612476604	1356	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|CYTOSKELETON ORGANIZATION	NUCLEUS		Deoxyhypusine hydroxylase; HEAT-repeat containing metalloenzyme that catalyzes hypusine formation; binds to and is required for the modification of Hyp2p (eIF5A); complements S. pombe mmd1 mutants defective in mitochondrial positioning; protein abundance increases in response to DNA replication stress	microtubule cytoskeleton organization|peptidyl-lysine modification to hypusine	deoxyhypusine monooxygenase activity	nucleus|cytoplasm
YLR176C	YLR176C	RFX1	hom	Verified	0.228353167233373	0.409685847365962	no	1895	0.408730857795989	1370	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Major transcriptional repressor of DNA-damage-regulated genes, recruits repressors Tup1p and Cyc8p to their promoters; involved in DNA damage and replication checkpoint pathway; similar to a family of mammalian DNA binding RFX1-4 proteins	negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding	nucleus|cytoplasm
YDR204W	YDR204W	COQ4	hom	Verified	0.228320444891537	0.409698565777861	no	1896	0.403892704596665	1328	NA	FT	KETONE METABOLISM|COFACTOR METABOLISM	MITOCHONDRION		Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex	ubiquinone biosynthetic process	molecular_function	mitochondrial inner membrane
YPL244C	YPL244C	HUT1	hom	Verified	0.22740988278512	0.410052518119442	no	1897	0.40225328661368	1321	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein with a role in UDP-galactose transport to the Golgi lumen, has similarity to human UDP-galactose transporter UGTrel1, exhibits a genetic interaction with S. cerevisiae ERO1	UDP-galactose transport|UDP-glucose transport	UDP-galactose transmembrane transporter activity	integral to membrane
YDR262W_p	YDR262W	YDR262W	hom	Uncharacterized	0.226279144573816	0.410492158986465	no	1898	0.39828711542387	1331	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole and is induced in response to the DNA-damaging agent MMS; gene expression increases in response to Zymoliase treatment	biological_process	molecular_function	fungal-type vacuole
YBL008W	YBL008W	HIR1	hom	Verified	0.224871287465373	0.411039703272118	no	1899	0.418411106974653	1368	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION	NUCLEUS|CHROMOSOME		Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; contributes to nucleosome formation, heterochromatic gene silencing, and formation of functional kinetochores	DNA replication-independent nucleosome assembly|regulation of transcription from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter	nucleosome binding|transcription corepressor activity|DNA binding	chromosome, centromeric region|HIR complex|nucleus
YBR046C	YBR046C	ZTA1	hom	Verified	0.224803033760532	0.411066252941852	no	1900	0.416141911544816	1381	NA	FT	OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		NADPH-dependent quinone reductase, GFP-tagged protein localizes to the cytoplasm and nucleus; has similarity to E. coli quinone oxidoreductase and to human zeta-crystallin	cellular response to oxidative stress	NADPH:quinone reductase activity|AU-rich element binding|2-alkenal reductase [NAD(P)] activity	nucleus|cytoplasm
YDL197C	YDL197C	ASF2	hom	Verified	0.224311177307112	0.41125758977955	no	1901	0.4056284116483	1331	NA	FT	GENE SILENCING	NUCLEUS|CHROMOSOME		Anti-silencing protein that causes derepression of silent loci when overexpressed	chromatin silencing at silent mating-type cassette	molecular_function	nuclear chromosome, telomeric region|nucleus
YJL176C	YJL176C	SWI3	hom	Verified	0.224014449370464	0.411373029981128	no	1902	0.421744852277688	1419	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS	NUCLEUS	RSC COMPLEX	Subunit of the SWI/SNF chromatin remodeling complex; SWI/SNF regulates transcription by remodeling chromosomes; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2; relocates to the cytosol under hypoxic conditions	cellular alcohol catabolic process|ATP-dependent chromatin remodeling|positive regulation of mating type switching|sucrose catabolic process|carbon catabolite activation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter	histone binding|DNA binding	SWI/SNF complex|nucleus
YIR037W	YIR037W	HYR1	hom	Verified	0.223986602164896	0.411383864161347	no	1903	0.41421013014175	1371	NA	FT	OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS			Thiol peroxidase that functions as a hydroperoxide receptor to sense intracellular hydroperoxide levels and transduce a redox signal to the Yap1p transcription factor	cellular response to oxidative stress	phospholipid-hydroperoxide glutathione peroxidase activity|glutathione peroxidase activity	intracellular
YNL043C_d	YNL043C	YNL043C	hom	Dubious	0.223291832793773	0.4116541916509	no	1904	0.415633133323821	1394	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YIP3/YNL044W	Unknown	Unknown	Unknown
YGR131W	YGR131W	FHN1	hom	Verified	0.222824492708962	0.411836052387708	no	1905	0.419033555591582	1402	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION	PLASMA MEMBRANE		Protein of unknown function; induced by ketoconazole; promoter region contains sterol regulatory element motif, which has been identified as a Upc2p-binding site; overexpression complements function of Nce102p in NCE102 deletion strain	establishment of protein localization to plasma membrane	molecular_function	integral to membrane|membrane raft
YML106W	YML106W	URA5	hom	Verified	0.222586604806092	0.411928631370685	no	1906	0.411864838933377	1364	NA	FT	NUCLEOTIDE METABOLISM	NUCLEUS		Major orotate phosphoribosyltransferase (OPRTase) isozyme; catalyzes the fifth enzymatic step in de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; URA5 has a paralog, URA10, that arose from the whole genome duplication	'de novo' pyrimidine nucleobase biosynthetic process|pyrimidine ribonucleoside biosynthetic process	orotate phosphoribosyltransferase activity	nucleus|cytoplasm
YPR170C_d	YPR170C	YPR170C	hom	Dubious	0.222487815075349	0.41196707887248	no	1907	0.461679827844578	1524	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORFs YPR169W-A and YPR170W-B	Unknown	Unknown	Unknown
YER116C	YER116C	SLX8	hom	Verified	0.221704198293312	0.412272080839797	no	1908	0.362006468813201	1184	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS	UBIQUITIN LIGASE COMPLEX	Subunit of Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex; stimulated by prior attachment of SUMO to the substrate; contains a C-terminal RING domain; forms nuclear foci upon DNA replication stress	protein sumoylation|telomere maintenance|response to DNA damage stimulus|protein ubiquitination	ubiquitin-protein ligase activity	ubiquitin ligase complex|nucleus
YDR511W	YDR511W	ACN9	hom	Verified	0.220515332862667	0.412734916181912	no	1909	0.374769415245274	1242	NA	FT	KETONE METABOLISM|CARBOHYDRATE METABOLISM	MITOCHONDRION		Protein of the mitochondrial intermembrane space, required for acetate utilization and gluconeogenesis; has orthologs in higher eukaryotes	carbon utilization|regulation of gluconeogenesis	molecular_function	mitochondrion|mitochondrial intermembrane space
YPR159C-A_p	YPR159C-A	YPR159C-A	hom	Uncharacterized	0.217959945096864	0.413730160144043	no	1910	0.40933038859966	1334	NA					Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching	biological_process	molecular_function	cellular_component
YGL015C_p	YGL015C	YGL015C	hom	Uncharacterized	0.217128416003837	0.414054134702922	no	1911	0.406535884478966	1331	NA					Putative protein of unknown function; null mutants accumulate cargo in the Golgi	biological_process	molecular_function	cellular_component
YOR275C	YOR275C	RIM20	hom	Verified	0.216987331091018	0.414109109032067	no	1912	0.407987287294506	1357	NA	FT	ION HOMEOSTASIS|PROTEOLYSIS|ION HOMEOSTASIS	NUCLEUS		Protein involved in proteolytic activation of Rim101p in response to alkaline pH; PalA/AIP1/Alix family member; interaction with the ESCRT-III subunit Snf7p suggests a relationship between pH response and multivesicular body formation	proteolysis|response to pH|protein processing|invasive growth in response to glucose limitation|sporulation resulting in formation of a cellular spore	molecular_function	nucleus|cytoplasm
YNL049C	YNL049C	SFB2	hom	Verified	0.214174501475403	0.415205489799842	no	1913	0.407729361145452	1347	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Component of the Sec23p-Sfb2p heterodimer of the COPII vesicle coat, required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sec24p and Sfb3p	cargo loading into COPII-coated vesicle	signal sequence binding	COPII vesicle coat
YCR034W	YCR034W	FEN1	hom	Verified	0.214125046179413	0.415224772350078	no	1914	0.464483856293972	1830	NA	FF|FT	VESICLE-MEDIATED TRANSPORT|KETONE METABOLISM|LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Fatty acid elongase, involved in sphingolipid biosynthesis; acts on fatty acids of up to 24 carbons in length; mutations have regulatory effects on 1,3-beta-glucan synthase, vacuolar ATPase, and the secretory pathway; FEN1 has a paralog, ELO1, that arose from the whole genome duplication	fatty acid elongation|vesicle-mediated transport|sphingolipid biosynthetic process	fatty acid elongase activity	integral to membrane|endoplasmic reticulum|endoplasmic reticulum membrane
YJR119C	YJR119C	JHD2	hom	Verified	0.213606890464126	0.415426812802257	no	1915	0.384892219912177	1268	NA	FT	CHROMATIN ORGANIZATION|OXIDATION-REDUCTION PROCESS	NUCLEUS		JmjC domain family histone demethylase specific for H3-K4 (histone H3 Lys4); removes methyl groups specifically added by Set1p methyltransferase; protein levels regulated by Not4p (E3 ubiquitin ligase) polyubiquitin-mediated degradation	histone demethylation	histone demethylase activity (H3-K4 specific)	nucleus|cytoplasm
YDL076C	YDL076C	RXT3	hom	Verified	0.212470300359191	0.415870072851677	no	1916	0.420003120343167	1394	NA	FT	CHROMATIN ORGANIZATION	NUCLEUS|CHROMOSOME		Subunit of the RPD3L complex; involved in histone deacetylation; protein abundance increases in response to DNA replication stress	negative regulation of transcription from RNA polymerase I promoter	molecular_function	Rpd3L-Expanded complex|nucleus|Rpd3L complex
YHL013C	YHL013C	OTU2	hom	Verified	0.211030536224391	0.416431721710552	no	1917	0.394621322293613	1317	NA					Protein of unknown function; may interact with ribosomes, based on co-purification experiments; member of the ovarian tumor-like (OTU) superfamily of predicted cysteine proteases; shows cytoplasmic localization; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	ribosome|cytoplasm
YGR217W	YGR217W	CCH1	hom	Verified	0.210088183477668	0.416799423950343	no	1918	0.426423538232245	1424	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together	calcium ion transport	voltage-gated calcium channel activity|calcium channel activity	integral to membrane|plasma membrane
YDL133W	YDL133W	SRF1	hom	Verified	0.209194268942377	0.417148293087107	no	1919	0.467687937381274	1541	NA					Regulator of phospholipase D (Spo14p); interacts with Spo14p and regulates its catalytic activity; capable of buffering the toxicity of C16:0 platelet activating factor, a lipid that accumulates intraneuronally in Alzheimer's patients	positive regulation of catalytic activity	molecular_function	integral to membrane
YDR433W_d	YDR433W	YDR433W	hom	Dubious	0.20869767275664	0.41734212850544	no	1920	0.422611843684328	1407	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YKR011C	YKR011C	YKR011C	hom	Verified	0.207827583046392	0.417681797329857	no	1921	0.416795813930771	1354	NA	FT		NUCLEUS		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	nucleus
YMR069W	YMR069W	NAT4	hom	Verified	0.207635574182762	0.41775676273907	no	1922	0.432200959192546	1424	NA	FT	CHROMATIN ORGANIZATION	NUCLEUS		N alpha-acetyl-transferase, involved in acetylation of the N-terminal residues of histones H4 and H2A	histone acetylation	histone acetyltransferase activity	nucleus|cytoplasm
YCR081W	YCR081W	SRB8	hom	Verified	0.206312470313147	0.418273419085161	no	1923	0.429687238371999	1416	NA	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; involved in glucose repression	negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription by galactose|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II transcription coactivator activity	mediator complex
YFR041C	YFR041C	ERJ5	hom	Verified	0.205627662685513	0.418540883780394	no	1924	0.402929254587796	1307	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Type I membrane protein with a J domain is required to preserve the folding capacity of the endoplasmic reticulum; loss of the non-essential ERJ5 gene leads to a constitutively induced unfolded protein response	protein folding	molecular_function	endoplasmic reticulum
YOL023W	YOL023W	IFM1	hom	Verified	0.204142895965235	0.419120916977405	no	1925	0.432405877030812	1396	NA	FT	TRANSLATION|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial translation initiation factor 2	translational initiation|mitochondrial translational initiation|mitochondrial translation	tRNA binding|GTPase activity|translation initiation factor activity	mitochondrion
YPR071W_p	YPR071W	YPR071W	hom	Uncharacterized	0.202834498419186	0.419632196265837	no	1926	0.437786791365471	1447	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Putative membrane protein; YPR071W is not an essential gene; YPR071W has paralog YIL029C	biological_process	molecular_function	integral to membrane
YDR254W	YDR254W	CHL4	hom	Verified	0.201793367135163	0.420039133571656	no	1927	0.419316871476223	1362	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME	KINETOCHORE	Outer kinetochore protein required for chromosome stability; involved in new kinetochore assembly and sister chromatid cohesion; peripheral component of the Ctf19 kinetochore complex that interacts with Ctf19p, Ctf3p, Iml3p and Mif2p; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-N and fission yeast mis15	kinetochore assembly|chromosome segregation|establishment of meiotic sister chromatid cohesion|protein localization to chromosome, centromeric region|maintenance of meiotic sister chromatid cohesion|establishment of mitotic sister chromatid cohesion	structural molecule activity	condensed nuclear chromosome outer kinetochore
YLR437C	YLR437C	DIF1	hom	Verified	0.20097032938944	0.420360887217759	no	1928	0.411500616600436	1357	NA	FT		NUCLEUS		Protein that regulates the nuclear localization of ribonucleotide reductase Rnr2p and Rnr4p subunits; phosphorylated by Dun1p in response to DNA damage and degraded; N-terminal half has similarity to S. pombe Spd1 protein	biological_process	molecular_function	cytoplasm
YDR261C	YDR261C	EXG2	hom	Verified	0.199064804130253	0.42110602622227	no	1929	0.417721877494623	1385	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	PLASMA MEMBRANE		Exo-1,3-beta-glucanase, involved in cell wall beta-glucan assembly; may be anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor	fungal-type cell wall organization	glucan exo-1,3-beta-glucosidase activity	fungal-type cell wall
YDR250C_d	YDR250C	YDR250C	hom	Dubious	0.196745269782103	0.42201344111723	no	1930	0.422748488112719	1413	NA					Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data	Unknown	Unknown	Unknown
YLR013W	YLR013W	GAT3	hom	Verified	0.196057781413464	0.422282470224521	no	1931	0.421557424086436	1371	NA	FT		NUCLEUS		Protein containing GATA family zinc finger motifs	transcription, DNA-dependent	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	nucleus
YKL204W	YKL204W	EAP1	hom	Verified	0.195792548913692	0.422386271154265	no	1932	0.437438952601517	1444	NA	FT	TRANSLATION			eIF4E-associated protein, competes with eIF4G for binding to eIF4E; accelerates mRNA degradation by promoting decapping, facilitated by interaction with eIF4E; essential for Puf5p mediated repression; associates with Puf5p and Dhh1p; inhibits cap-dependent translation; functions independently of eIF4E to maintain genetic stability; plays a role in cell growth, implicated in the TOR signaling cascade	negative regulation of translation	eukaryotic initiation factor 4E binding	mRNA cap binding complex|cytoplasmic stress granule
YNL142W	YNL142W	MEP2	hom	Verified	0.194917151182759	0.422728903505521	no	1933	0.413056265541904	1378	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Ammonium permease involved in regulation of pseudohyphal growth; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation	nitrogen utilization|ammonium transport|pseudohyphal growth	ammonium transmembrane transporter activity	integral to membrane|plasma membrane
YDR058C	YDR058C	TGL2	hom	Verified	0.194487150448956	0.42289722804707	no	1934	0.429658333544788	1416	NA	FT	PROTEIN LOCALIZATION|LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION		Triacylglycerol lipase that is localized to the mitochondria; has lipolytic activity towards triacylglycerols and diacylglycerols when expressed in E. coli	triglyceride catabolic process	triglyceride lipase activity	mitochondrion
YIL099W	YIL099W	SGA1	hom	Verified	0.193396762736788	0.423324125270226	no	1935	0.424688662621934	1409	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY			Intracellular sporulation-specific glucoamylase involved in glycogen degradation; induced during starvation of a/a diploids late in sporulation, but dispensable for sporulation	ascospore formation|glycogen catabolic process	glucan 1,4-alpha-glucosidase activity	fungal-type vacuole
YNL120C_d	YNL120C	YNL120C	hom	Dubious	0.192979124198464	0.423487658627019	no	1936	0.418957363991692	1390	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; deletion enhances replication of Brome mosaic virus in S. cerevisiae, but likely due to effects on the overlapping gene	Unknown	Unknown	Unknown
YJL183W	YJL183W	MNN11	hom	Verified	0.192811976722794	0.423553111712222	no	1937	0.435369305318441	1435	NA	FT	CARBOHYDRATE METABOLISM	GOLGI APPARATUS		Subunit of a Golgi mannosyltransferase complex that also contains Anp1p, Mnn9p, Mnn10p, and Hoc1p, and mediates elongation of the polysaccharide mannan backbone; has homology to Mnn10p	protein glycosylation	alpha-1,6-mannosyltransferase activity	alpha-1,6-mannosyltransferase complex
YPR101W	YPR101W	SNT309	hom	Verified	0.19266493898787	0.423610691791577	no	1938	0.42763127267237	1421	NA	FT	RNA PROCESSING	NUCLEUS		Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; interacts physically and genetically with Prp19p	mRNA splicing, via spliceosome	first spliceosomal transesterification activity	Prp19 complex|U2-type catalytic step 1 spliceosome
YJL160C_p	YJL160C	YJL160C	hom	Uncharacterized	0.1913408422323	0.42412928234297	no	1939	0.444612159268313	1481	NA					Putative protein of unknown function; member of the PIR (proteins with internal repeats) family of cell wall proteins; non-essential gene that is required for sporulation; mRNA is weakly cell cycle regulated, peaking in mitosis; YJL160C has a paralog, PIR1, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YDR099W	YDR099W	BMH2	hom	Verified	0.19079175411005	0.42434437464167	no	1940	0.431880270076253	1416	NA	FT	CELL CYCLE|SIGNALING|RESPONSE TO DNA DAMAGE|CELL WALL ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS		14-3-3 protein, minor isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress	glycogen metabolic process|ascospore formation|Ras protein signal transduction|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|DNA damage checkpoint|DNA replication initiation|signal transduction involved in filamentous growth|pseudohyphal growth|fungal-type cell wall chitin biosynthetic process|pre-replicative complex assembly	DNA replication origin binding|phosphoserine binding	nucleus|plasma membrane
YHR199C	YHR199C	AIM46	hom	Verified	0.189269912946231	0.424940637547961	no	1941	0.499996597374965	1678	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss	biological_process	molecular_function	mitochondrion
YMR215W	YMR215W	GAS3	hom	Verified	0.189234196897499	0.424954633293994	no	1942	0.412134807940389	1318	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM			Low abundance, possibly inactive member of the GAS family of GPI-containing proteins; putative 1,3-beta-glucanosyltransferase with similarity to other GAS family members; localizes to the cell wall; mRNA induced during sporulation	biological_process	1,3-beta-glucanosyltransferase activity	fungal-type cell wall|integral to membrane|plasma membrane
YOL152W	YOL152W	FRE7	hom	Verified	0.188840689780397	0.425108839859401	no	1943	0.429756980848172	1444	NA	FT	ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|GEN. OF PRECURSOR METABOLITES AND ENERGY	PLASMA MEMBRANE		Putative ferric reductase with similarity to Fre2p; expression induced by low copper levels	iron ion transport|copper ion import	ferric-chelate reductase activity	integral to membrane|plasma membrane
YLR410W	YLR410W	VIP1	hom	Verified	0.188295906755506	0.425322346951257	no	1944	0.410573338530355	1346	NA	FT		CYTOSKELETON		Inositol hexakisphosphate (IP6) and inositol heptakisphosphate (IP7) kinase; IP7 production is important for phosphate signaling; involved in cortical actin cytoskeleton function, and invasive pseudohyphal growth analogous to S. pombe asp1	inositol phosphate biosynthetic process	inositol hexakisphosphate 1-kinase activity|inositol hexakisphosphate 3-kinase activity|inositol heptakisphosphate kinase activity|inositol hexakisphosphate 4-kinase activity|inositol hexakisphosphate 6-kinase activity	cytoplasm
YDR315C	YDR315C	IPK1	hom	Verified	0.187587280043198	0.42560009914156	no	1945	0.459595652156662	1518	NA	FT		NUCLEUS		Inositol 1,3,4,5,6-pentakisphosphate 2-kinase, nuclear protein required for synthesis of 1,2,3,4,5,6-hexakisphosphate (phytate), which is integral to cell function; has 2 motifs conserved in other fungi; ipk1 gle1 double mutant is inviable	nuclear-transcribed mRNA catabolic process, non-stop decay|inositol phosphate biosynthetic process	inositol pentakisphosphate 2-kinase activity	nucleus
YBR094W	YBR094W	PBY1	hom	Verified	0.187050890753129	0.425810365987757	no	1946	0.42146995486042	1387	NA					Putative tubulin tyrosine ligase associated with P-bodies; forms cytoplasmic foci upon DNA replication stress	nuclear-transcribed mRNA catabolic process|biological_process	molecular_function	cytoplasmic mRNA processing body|cytoplasm
YMR311C	YMR311C	GLC8	hom	Verified	0.186146114539925	0.426165089826666	no	1947	0.435253658470371	1430	NA	FT	SIGNALING|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|CHROMOSOME SEGREGATION	NUCLEUS		Regulatory subunit of protein phosphatase 1 (Glc7p); involved in glycogen metabolism and chromosome segregation; proposed to regulate Glc7p activity via conformational alteration; ortholog of the mammalian protein phosphatase inhibitor 2; protein abundance increases in response to DNA replication stress	chromosome segregation|glycogen biosynthetic process	enzyme activator activity	nucleus|cytoplasm
YLR164W	YLR164W	SHH4	hom	Verified	0.185702002564564	0.426339228909836	no	1948	0.406161449465238	1349	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Mitochondrial inner membrane protein of unknown function; similar to Tim18p and Sdh4p; a fraction copurifies with Sdh3p, but Shh4p is neither a stoichiometric subunit of succinate dehydrogenase nor of the TIM22 translocase; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner	biological_process	molecular_function	mitochondrion|mitochondrial inner membrane
YPR193C	YPR193C	HPA2	hom	Verified	0.185499284631203	0.426418720655461	no	1949	0.414639925881643	1366	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CHROMATIN ORGANIZATION			Tetrameric histone acetyltransferase with similarity to Gcn5p, Hat1p, Elp3p, and Hpa3p; acetylates histones H3 and H4 in vitro and exhibits autoacetylation activity	protein homotetramerization|histone acetylation	histone acetyltransferase activity|protein homodimerization activity	cytoplasm
YGR255C	YGR255C	COQ6	hom	Verified	0.184346206341832	0.426870933797079	no	1950	0.425784786147222	1419	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM	MITOCHONDRION		Putative flavin-dependent monooxygenase; involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; human COX6 can rescue a yeast cox6 mutant and is implicated in steroid-resistant nephrotic syndrome (SRNS)	ubiquinone biosynthetic process	N,N-dimethylaniline monooxygenase activity	mitochondrion|mitochondrial inner membrane
YMR247W-A_p	YMR247W-A	YMR247W-A	hom	Uncharacterized	0.183830839653899	0.427073080932749	no	1951	0.420337923113226	1384	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YLR294C_d	YLR294C	YLR294C	hom	Dubious	0.183604312796669	0.427161939760353	no	1952	0.433434529972178	1426	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene ATP14	Unknown	Unknown	Unknown
YDR194C	YDR194C	MSS116	hom	Verified	0.182464699302086	0.427609027581566	no	1953	0.437618197529633	1417	NA	FT	RNA PROCESSING|TRANSLATION	MITOCHONDRION		DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing	RNA folding|Group I intron splicing|Group II intron splicing	RNA binding|RNA strand annealing activity|ATP-dependent RNA helicase activity	mitochondrion|mitochondrial matrix
YPL164C	YPL164C	MLH3	hom	Verified	0.181862168478799	0.427845447258277	no	1954	0.429785787193152	1412	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Protein involved in DNA mismatch repair and crossing-over during meiotic recombination; forms a complex with Mlh1p; mammalian homolog is implicated mammalian microsatellite instability	mismatch repair|reciprocal meiotic recombination	molecular_function	nucleus|MutLbeta complex
YMR145C	YMR145C	NDE1	hom	Verified	0.181255477969058	0.42808352527974	no	1955	0.43259298330294	1411	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Mitochondrial external NADH dehydrogenase, a type II NAD(P)H:quinone oxidoreductase that catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p provide cytosolic NADH to the mitochondrial respiratory chain	glucose catabolic process to ethanol|NADH oxidation|chronological cell aging	NADH dehydrogenase activity	mitochondrion
YER047C	YER047C	SAP1	hom	Verified	0.181074031948386	0.428154733576129	no	1956	0.446423737031746	1458	NA					Putative ATPase of the AAA family, interacts with the Sin1p transcriptional repressor in the two-hybrid system	biological_process	ATPase activity	cytoplasm
YDL032W_d	YDL032W	YDL032W	hom	Dubious	0.180973844635542	0.428194052982414	no	1957	0.461874656175465	1530	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene SLM3/YDL033C; YDL032W is not an essential gene	Unknown	Unknown	Unknown
YFL046W_p	YFL046W	FMP32	hom	Uncharacterized	0.179663263677952	0.428708467710467	no	1958	0.437960185229361	1438	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YDR507C	YDR507C	GIN4	hom	Verified	0.178839467075447	0.429031877291046	no	1959	0.450667434002432	1512	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION	SITE OF POLARIZED GROWTH		Protein kinase involved in bud growth and assembly of the septin ring; proposed to have kinase-dependent and kinase-independent activities; undergoes autophosphorylation; similar to Hsl1p; GIN4 has a paralog, KCC4, that arose from the whole genome duplication	protein autophosphorylation|budding cell bud growth|protein phosphorylation|septin checkpoint|septin ring assembly	protein kinase activity	cellular bud neck
YKR031C	YKR031C	SPO14	hom	Verified	0.178512191999851	0.429160373572202	no	1960	0.429661318901265	1425	NA	FT	VESICLE-MEDIATED TRANSPORT|CELL CYCLE|LIPID METABOLISM	NUCLEUS		Phospholipase D; catalyzes the hydrolysis of phosphatidylcholine, producing choline and phosphatidic acid; involved in Sec14p-independent secretion; required for meiosis and spore formation; differently regulated in secretion and meiosis; participates in transcription initiation and/or early elongation of specific genes; interacts with foot domain of RNA polymerase II; deletion results in abnormal CTD-Ser5 phosphorylation of RNA polymerase II at specific promoter regions	phospholipid metabolic process|exocytosis|cell morphogenesis involved in conjugation with cellular fusion|ascospore-type prospore assembly	phospholipase D activity|phosphatidylinositol-3-phosphate binding	endosome|nucleus|prospore membrane
YGR038W	YGR038W	ORM1	hom	Verified	0.174989432202699	0.430543968672469	no	1961	0.442396369907783	1467	NA	FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Evolutionarily conserved protein, similar to Orm2p, required for resistance to agents that induce unfolded protein response; Orm1p and Orm2p together control membrane biogenesis by coordinating lipid homeostasis with protein quality control	cellular sphingolipid homeostasis|negative regulation of sphingolipid biosynthetic process|response to unfolded protein	molecular_function	integral to membrane|endoplasmic reticulum|SPOTS complex
YNR019W	YNR019W	ARE2	hom	Verified	0.174615690593614	0.430690809349202	no	1962	0.433902220047537	1427	NA	FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Acyl-CoA:sterol acyltransferase; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the presence of oxygen; ARE2 has a paralog, ARE1, that arose from the whole genome duplication	ergosterol metabolic process	ergosterol O-acyltransferase activity	integral to membrane|endoplasmic reticulum
YOR376W-A_p	YOR376W-A	YOR376W-A	hom	Uncharacterized	0.174020851514796	0.430924537557172	no	1963	0.431634052647589	1407	NA					Putative protein of unknown function; identified by fungal homology and RT-PCR	biological_process	molecular_function	cellular_component
YBL036C	YBL036C	YBL036C	hom	Verified	0.173693816685263	0.431053048614994	no	1964	0.402334385770023	1315	NA					Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS	biological_process	pyridoxal phosphate binding	cellular_component
YFL028C	YFL028C	CAF16	hom	Verified	0.173391448944703	0.431171873030195	no	1965	0.425077520434785	1372	NA	FT	TRANSCRIPTION FROM RNA POL II|NUCLEOTIDE METABOLISM	NUCLEUS		Part of evolutionarily-conserved CCR4-NOT regulatory complex; contains single ABC-type ATPase domain but no transmembrane domain; interacts with several subunits of Mediator	regulation of transcription from RNA polymerase II promoter	ATPase activity	CCR4-NOT complex|cytoplasm
YCR068W	YCR068W	ATG15	hom	Verified	0.172484416506034	0.43152835579158	no	1966	0.442461732552488	1454	NA	FT	LIPID METABOLISM|MEMBRANE ORGANIZATION|VACUOLAR PROTEIN PROCESSING	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Lipase required for intravacuolar lysis of autophagic bodies and Cvt bodies; targeted to intravacuolar vesicles during autophagy via the multivesicular body (MVB) pathway	membrane disassembly|autophagy|piecemeal microautophagy of nucleus|vacuolar protein processing|multivesicular body membrane disassembly	lipase activity	integral to membrane|vacuolar lumen
YPR117W_p	YPR117W	YPR117W	hom	Uncharacterized	0.171771032613078	0.431808769814479	no	1967	0.434480629907492	1441	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YLR239C	YLR239C	LIP2	hom	Verified	0.170372800988344	0.432358480536202	no	1968	0.49406148710906	1647	NA	FF|FT	KETONE METABOLISM|LIPID METABOLISM|COFACTOR METABOLISM	MITOCHONDRION		Lipoyl ligase, involved in the modification of mitochondrial enzymes by the attachment of lipoic acid groups	protein lipoylation	ligase activity	mitochondrion
YOR178C	YOR178C	GAC1	hom	Verified	0.169649489549807	0.432642899802408	no	1969	0.435721800406603	1426	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY			Regulatory subunit for Glc7p type-1 protein phosphatase (PP1), tethers Glc7p to Gsy2p glycogen synthase, binds Hsf1p heat shock transcription factor, required for induction of some HSF-regulated genes under heat shock	meiosis|glycogen metabolic process|negative regulation of transcription from RNA polymerase II promoter|response to heat|mitotic cell cycle spindle assembly checkpoint	protein phosphatase type 1 regulator activity|structural molecule activity|heat shock protein binding	protein phosphatase type 1 complex
YPR027C_p	YPR027C	YPR027C	hom	Uncharacterized	0.169099061600376	0.432859361517773	no	1970	0.432761826059366	1451	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YJL049W_p	YJL049W	YJL049W	hom	Uncharacterized	0.16841091753411	0.433130009911683	no	1971	0.396247850435201	1318	NA	FT	PROTEIN LOCALIZATION			Putative protein of unknown function; YJL049W is a non-essential gene	biological_process	molecular_function	cellular_component
YDR358W	YDR358W	GGA1	hom	Verified	0.168308320392694	0.433170364256075	no	1972	0.433693180492494	1408	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEOLYSIS|VACUOLAR TRANSPORT	GOLGI APPARATUS		Golgi-localized protein with homology to gamma-adaptin, interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner in order to facilitate traffic through the late Golgi	Golgi to vacuole transport|protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|Golgi to endosome transport	ubiquitin binding	trans-Golgi network
YPL188W	YPL188W	POS5	hom	Verified	0.168210777284665	0.433208731353041	no	1973	0.436083088457978	1433	NA	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS	MITOCHONDRION		Mitochondrial NADH kinase, phosphorylates NADH; also phosphorylates NAD(+) with lower specificity; required for the response to oxidative stress	cellular response to oxidative stress|NADP biosynthetic process	NADH kinase activity	mitochondrion|mitochondrial matrix
YOR316C	YOR316C	COT1	hom	Verified	0.168164350920932	0.43322699267776	no	1974	0.442059557032477	1454	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Vacuolar transporter that mediates zinc transport into the vacuole; overexpression confers resistance to cobalt and rhodium; protein abundance increases in response to DNA replication stress; COT1 has a paralog, ZRC1, that arose from the whole genome duplication	cellular zinc ion homeostasis|cobalt ion transport|zinc ion transport	cobalt ion transmembrane transporter activity|zinc ion transmembrane transporter activity|inorganic cation transmembrane transporter activity	mitochondrion|integral to membrane|fungal-type vacuole
YLL016W	YLL016W	SDC25	hom	pseudogene	0.168059938634452	0.433268062679686	no	1975	0.437636182008307	1456	NA	FT	SIGNALING			Non-essential Ras guanine nucleotide exchange factor (GEF); localized to the membrane; expressed in poor nutrient conditions and on nonfermentable carbon sources; contains a stop codon in S288C, full-length gene includes YLL017W; SDC25 has a paralog, CDC25, that arose from the whole genome duplication	Ras protein signal transduction	Ras guanyl-nucleotide exchange factor activity	cellular_component
YJR073C	YJR073C	OPI3	hom	Verified	0.167906170885115	0.433328547695106	no	1976	0.441363534201044	1460	NA	FF|FT	LIPID METABOLISM	MITOCHONDRION		Phospholipid methyltransferase (methylene-fatty-acyl-phospholipid synthase), catalyzes the last two steps in phosphatidylcholine biosynthesis	phosphatidylcholine biosynthetic process	phosphatidyl-N-dimethylethanolamine N-methyltransferase activity|phosphatidyl-N-methylethanolamine N-methyltransferase activity	mitochondrion|integral to membrane
YJL210W	YJL210W	PEX2	hom	Verified	0.166954371576719	0.433702975566368	no	1977	0.4293788989757	1420	NA	FT	PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION			RING-finger peroxin and E3 ubiquitin ligase, peroxisomal membrane protein with a C-terminal zinc-binding RING domain, forms translocation subcomplex with Pex10p and Pex12p which functions in peroxisomal matrix protein import	protein import into peroxisome matrix	ubiquitin-protein ligase activity|protein binding	peroxisomal membrane
YER167W	YER167W	BCK2	hom	Verified	0.166543780513622	0.433864516177256	no	1978	0.460441554299329	1529	NA	FT	CELL CYCLE	NUCLEUS		Protein rich in serine and threonine residues involved in protein kinase C signaling pathway, which controls cell integrity; overproduction suppresses pkc1 mutations	regulation of cell cycle|positive regulation of gene expression|G1/S transition of mitotic cell cycle	molecular_function	nucleus|cytoplasm
YBL062W_d	YBL062W	YBL062W	hom	Dubious	0.166427352115293	0.433910325115113	no	1979	0.458349650572926	1515	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YNL235C_d	YNL235C	YNL235C	hom	Dubious	0.166058959312027	0.434055275692247	no	1980	0.446331544683328	1476	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SIN4/YNL236W, a subunit of the mediator complex	Unknown	Unknown	Unknown
YDR024W_d	YDR024W	FYV1	hom	Dubious	0.164405281788531	0.434706052942437	no	1981	0.444623649113957	1494	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; mutation decreases survival upon exposure to K1 killer toxin	Unknown	Unknown	Unknown
YBR301W	YBR301W	PAU24	hom	Verified	0.164096451896851	0.434827607464362	no	1982	0.442746450461322	1463	NA	FT	CELL WALL ORG/BIOGENESIS			Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; member of the seripauperin multigene family encoded mainly in subtelomeric regions; expressed under anaerobic conditions, completely repressed during aerobic growth	biological_process	molecular_function	fungal-type cell wall
YIR034C	YIR034C	LYS1	hom	Verified	0.161881724607788	0.435699497317953	no	1983	0.452000167644644	1508	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS			Saccharopine dehydrogenase (NAD+, L-lysine-forming), catalyzes the conversion of saccharopine to L-lysine, which is the final step in the lysine biosynthesis pathway; also has mRNA binding activity	lysine biosynthetic process|lysine biosynthetic process via aminoadipic acid	saccharopine dehydrogenase (NAD+, L-lysine-forming) activity|mRNA binding	cytoplasm
YJR043C	YJR043C	POL32	hom	Verified	0.158433371267668	0.437057659689062	no	1984	0.445397297652476	1467	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Third subunit of DNA polymerase delta, involved in chromosomal DNA replication; required for error-prone DNA synthesis in the presence of DNA damage and processivity; interacts with Hys2p, PCNA (Pol30p), and Pol1p	RNA-dependent DNA replication|lagging strand elongation|postreplication repair|base-excision repair|DNA replication, removal of RNA primer|nucleotide-excision repair|mismatch repair|double-strand break repair via break-induced replication|leading strand elongation	DNA-directed DNA polymerase activity|single-stranded DNA specific 3'-5' exodeoxyribonuclease activity	delta DNA polymerase complex|nucleus
YMR189W	YMR189W	GCV2	hom	Verified	0.158018274485809	0.437221199337106	no	1985	0.420523587776382	1389	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS	MITOCHONDRION		P subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of 5,10-methylene-THF in the cytoplasm	glycine decarboxylation via glycine cleavage system|one-carbon metabolic process	glycine dehydrogenase (decarboxylating) activity	mitochondrion|glycine cleavage complex
YJL199C_d	YJL199C	MBB1	hom	Dubious	0.157390430630453	0.437468577358324	no	1986	0.438825259903615	1431	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; protein detected in large-scale protein-protein interaction studies	Unknown	Unknown	Unknown
YOR237W	YOR237W	HES1	hom	Verified	0.157364367066502	0.437478847244757	no	1987	0.468509660031693	1565	NA	FT	VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|MEMBRANE ORGANIZATION			Protein implicated in the regulation of ergosterol biosynthesis; one of a seven member gene family with a common essential function and non-essential unique functions; similar to human oxysterol binding protein (OSBP); HES1 has a paralog, KES1, that arose from the whole genome duplication	maintenance of cell polarity|endocytosis|exocytosis|sterol transport	lipid binding|oxysterol binding|sterol transporter activity	cellular_component
YDR104C	YDR104C	SPO71	hom	Verified	0.155588394134505	0.43817873683347	no	1988	0.422276477019257	1394	NA	FT	CELL WALL ORG/BIOGENESIS			Meiosis-specific protein of unknown function, required for spore wall formation during sporulation, in particular for the proper size of the prospore membrane (PSM); interacts with SPO1; dispensable for both nuclear divisions during meiosis; contains two PH domains	ascospore wall assembly	molecular_function	ascospore wall
YHR117W	YHR117W	TOM71	hom	Verified	0.155426584282764	0.438242513797979	no	1989	0.439794283951631	1451	NA	FT		MITOCHONDRION		Mitochondrial outer membrane protein; probable minor component of the TOM (translocase of outer membrane) complex responsible for recognition and import of mitochondrially directed proteins; TOM71 has a paralog, TOM70, that arose from the whole genome duplication	biological_process	protein transporter activity	mitochondrial outer membrane|mitochondrion|integral to membrane|integral to mitochondrial outer membrane
YPR003C_p	YPR003C	YPR003C	hom	Uncharacterized	0.153892688099932	0.438847174738345	no	1990	0.421690178723997	1384	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Putative sulfate permease; physically interacts with Hsp82p; green fluorescent protein (GFP)-fusion protein localizes to the ER; YPR003C is not an essential gene	biological_process	molecular_function	integral to membrane|endoplasmic reticulum
YMR294W	YMR294W	JNM1	hom	Verified	0.153849023356135	0.438864389449965	no	1991	0.457501062098057	1523	NA	FF|FT	CELL CYCLE|CYTOSKELETON ORGANIZATION	CYTOSKELETON		Component of the yeast dynactin complex, consisting of Nip100p, Jnm1p, and Arp1p; required for proper nuclear migration and spindle partitioning during mitotic anaphase B	nuclear migration|establishment of mitotic spindle orientation	structural constituent of cytoskeleton	dynactin complex|cell cortex|spindle pole body|astral microtubule
YOR161C	YOR161C	PNS1	hom	Verified	0.153673516451347	0.438933583756735	no	1992	0.4390775144324	1469	NA	FT		PLASMA MEMBRANE		Protein of unknown function; has similarity to Torpedo californica tCTL1p, which is postulated to be a choline transporter, neither null mutation nor overexpression affects choline transport	biological_process	choline transmembrane transporter activity|molecular_function	integral to membrane|plasma membrane|integral to plasma membrane
YJL150W_d	YJL150W	YJL150W	hom	Dubious	0.153645617784453	0.438944583090912	no	1993	0.417212338234367	1378	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YHL034C	YHL034C	SBP1	hom	Verified	0.153573823032427	0.438972889121454	no	1994	0.428563597699417	1410	NA	FT	TRANSLATION	NUCLEUS		Protein that binds eIF4G and has a role in repression of translation; has an RGG motif; found in cytoplasmic P bodies; found associated with small nucleolar RNAs snR10 and snR11	negative regulation of translation|negative regulation of translation in response to stress	RNA binding|eukaryotic initiation factor 4G binding	nucleolus|cytoplasmic mRNA processing body|cytoplasm
YDR183W	YDR183W	PLP1	hom	Verified	0.153003397900294	0.439197797853189	no	1995	0.421806976124657	1367	NA	FT	TRANSCRIPTION FROM RNA POL II|SIGNALING			Protein that interacts with CCT (chaperonin containing TCP-1) complex and has a role in actin and tubulin folding; has weak similarity to phosducins, which are G-protein regulators	protein folding|positive regulation of transcription from RNA polymerase II promoter by pheromones	G-protein beta/gamma-subunit complex binding	cellular_component
YLR062C_d	YLR062C	BUD28	hom	Dubious	0.152837722465912	0.439263124484066	no	1996	0.451529887675353	1511	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene RPL22A; diploid mutant displays a weak budding pattern phenotype in a systematic assay	Unknown	Unknown	Unknown
YGL062W	YGL062W	PYC1	hom	Verified	0.151907188642564	0.43963006919086	no	1997	0.441385952502648	1462	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM			Pyruvate carboxylase isoform; cytoplasmic enzyme that converts pyruvate to oxaloacetate; differentially regulated than isoform Pyc2p; mutations in the human homolog are associated with lactic acidosis; PYC1 has a paralog, PYC2, that arose from the whole genome duplication	NADPH regeneration|gluconeogenesis	pyruvate carboxylase activity	cytosol
YOR097C_p	YOR097C	YOR097C	hom	Uncharacterized	0.15157820770408	0.439759811254097	no	1998	0.445649762160781	1495	NA					Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen; YOR097C is not an essential gene	biological_process	molecular_function	cellular_component
YDR497C	YDR497C	ITR1	hom	Verified	0.151387734274519	0.439834932290207	no	1999	0.434008418092392	1420	NA	FT		PLASMA MEMBRANE		Myo-inositol transporter; has strong similarity to the minor myo-inositol transporter Itr2p, member of the sugar transporter superfamily; expression is repressed by inositol and choline via Opi1p and derepressed via Ino2p and Ino4p; relative distribution to the vacuole increases upon DNA replication stress	myo-inositol transport|transmembrane transport	myo-inositol transmembrane transporter activity	integral to membrane|plasma membrane|membrane
YFR055W_p	YFR055W	IRC7	hom	Uncharacterized	0.150078987077558	0.440351149044869	no	2000	0.431934208192846	1397	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Beta-lyase involved in the production of thiols; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner and by copper levels in a Mac1-dependent manner	sulfur compound metabolic process|L-cysteine catabolic process to pyruvate	cysteine-S-conjugate beta-lyase activity	cellular_component
YML087C	YML087C	AIM33	hom	Verified	0.149681697282053	0.440507874468435	no	2001	0.435270032559906	1427	NA	FT	OXIDATION-REDUCTION PROCESS			Putative protein of unknown function, highly conserved across species; homolog of human CYB5R4; null mutant displays reduced frequency of mitochondrial genome loss; AIM33 has a paralog, PGA3, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YPL103C	YPL103C	FMP30	hom	Verified	0.147405114727993	0.441406134327311	no	2002	0.455319855168803	1499	NA	FT	LIPID METABOLISM	MITOCHONDRION		Mitochondrial inner membrane protein with a role in maintaining mitochondrial morphology and normal cardiolipin levels; proposed to be involved in N-acylethanolamine metabolism; related to mammalian N-acylPE-specific phospholipase D	N-acylphosphatidylethanolamine metabolic process|N-acylethanolamine metabolic process	NAPE-specific phospholipase D activity	mitochondrion|integral to mitochondrial inner membrane
YJR129C_p	YJR129C	YJR129C	hom	Uncharacterized	0.146940830682765	0.4415893617352	no	2003	0.436081441122946	1437	NA					Putative protein of unknown function; predicted S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	biological_process	S-adenosylmethionine-dependent methyltransferase activity	cytoplasm
YMR119W	YMR119W	ASI1	hom	Verified	0.146870828182067	0.44161698896217	no	2004	0.485671978330557	1616	NA	FT	PROTEOLYSIS	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM		Putative integral membrane E3 ubiquitin ligase; acts with Asi2p and Asi3p to ensure the fidelity of SPS-sensor signalling by maintaining the dormant repressed state of gene expression in the absence of inducing signals; ASI1 has a paralog, ASI3, that arose from the whole genome duplication	ubiquitin-dependent protein catabolic process	ubiquitin-protein ligase activity	integral to membrane|nuclear inner membrane|endoplasmic reticulum membrane
YAL004W_d	YAL004W	YAL004W	hom	Dubious	0.144880317945777	0.442402683233361	no	2005	0.45111300854842	1493	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene SSA1/YAL005C	Unknown	Unknown	Unknown
YNL044W	YNL044W	YIP3	hom	Verified	0.144678703194569	0.442482277305224	no	2006	0.445697465140954	1474	NA	FT	VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Protein localized to COPII vesicles, proposed to be involved in ER to Golgi transport; interacts with members of the Rab GTPase family and Yip1p; also interacts with Rtn1p	ER to Golgi vesicle-mediated transport	molecular_function	Golgi apparatus|endoplasmic reticulum|ER to Golgi transport vesicle
YPL249C	YPL249C	GYP5	hom	Verified	0.144443134409413	0.442575278792669	no	2007	0.436092407548171	1442	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING|NUCLEOTIDE METABOLISM	GOLGI APPARATUS|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		GTPase-activating protein (GAP) for yeast Rab family members; involved in ER to Golgi trafficking; exhibits GAP activity toward Ypt1p that is stimulated by Gyl1p, also acts on Sec4p; interacts with Gyl1p, Rvs161p and Rvs167p; involved in recruiting Rvs167p to the bud tip during polarized growth; relocalizes from bud neck to cytoplasm upon DNA replication stress	vesicle-mediated transport|ER to Golgi vesicle-mediated transport	Rab GTPase activator activity	cytosol|incipient cellular bud site|plasma membrane|cellular bud neck|Golgi-associated vesicle|cellular bud tip
YDL013W	YDL013W	SLX5	hom	Verified	0.143659275947706	0.44288476531277	no	2008	0.496084355343663	1666	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS	UBIQUITIN LIGASE COMPLEX	Subunit of the Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex, stimulated by SUMO-modified substrates; contains a RING domain and two SIMs (SUMO-interacting motifs); forms SUMO-dependent nuclear foci, including DNA repair centers	protein sumoylation|telomere maintenance|response to DNA damage stimulus|protein ubiquitination	SUMO binding|ubiquitin-protein ligase activity	ubiquitin ligase complex|nucleus
YBR289W	YBR289W	SNF5	hom	Verified	0.143415792015577	0.442980905836088	no	2009	0.487065703130452	1632	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS	NUCLEUS|CHROMOSOME	RSC COMPLEX	Subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; functions interdependently in transcriptional activation with Snf2p and Snf6p; relocates to the cytosol under hypoxic conditions	sucrose catabolic process|double-strand break repair via homologous recombination|chromatin remodeling|carbon catabolite activation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II activating transcription factor binding	SWI/SNF complex|nucleus
YGR011W_d	YGR011W	YGR011W	hom	Dubious	0.142346512293781	0.443403154525512	no	2010	0.44469059975583	1451	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YMR080C	YMR080C	NAM7	hom	Verified	0.141865801583491	0.443593003717897	no	2011	0.45066755054662	1473	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|RNA LOCALIZATION|GENE SILENCING	NUCLEUS		ATP-dependent RNA helicase of the SFI superfamily; involved in nonsense mediated mRNA decay; required for efficient translation termination at nonsense codons and targeting of NMD substrates to P-bodies; involved in telomere maintenance; forms cytoplasmic foci upon DNA replication stress	nuclear-transcribed mRNA catabolic process|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay|intracellular mRNA localization|translational frameshifting|regulation of translational termination|chromatin silencing at silent mating-type cassette|protein ubiquitination	RNA-dependent ATPase activity|ATP-dependent RNA helicase activity|nucleic acid binding	mitochondrion|polysome|cytoplasm
YGR017W_p	YGR017W	YGR017W	hom	Uncharacterized	0.140662798014784	0.444068167851595	no	2012	0.438512571897273	1442	NA	FT	OXIDATION-REDUCTION PROCESS	NUCLEUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm	biological_process	molecular_function	nucleus|cytoplasm
YGL166W	YGL166W	CUP2	hom	Verified	0.140614519580398	0.444087238622016	no	2013	0.451753256545422	1482	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Copper-binding transcription factor; activates transcription of the metallothionein genes CUP1-1 and CUP1-2 in response to elevated copper concentrations; CUP2 has a paralog, HAA1, that arose from the whole genome duplication	regulation of transcription from RNA polymerase II promoter|response to copper ion	RNA polymerase II core promoter proximal region sequence-specific DNA binding|copper ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity|copper ion binding	nucleus
YML081C-A	YML081C-A	ATP18	hom	Verified	0.140129621107296	0.444278788614774	no	2014	0.438766009328176	1452	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS	MITOCHONDRION		Subunit of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; termed subunit I or subunit j; does not correspond to known ATP synthase subunits in other organisms	mitochondrial proton-transporting ATP synthase complex assembly|ATP synthesis coupled proton transport	hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism	mitochondrion|mitochondrial proton-transporting ATP synthase complex|mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
YDR525W_d	YDR525W	API2	hom	Dubious	0.139424023389149	0.444557544918618	no	2015	0.476016331792079	1564	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 26% of ORF overlaps the dubious ORF YDR524C-A; insertion mutation in a cdc34-2 mutant background causes altered bud morphology	Unknown	Unknown	Unknown
YGR284C	YGR284C	ERV29	hom	Verified	0.138347352470587	0.444982951714936	no	2016	0.447866556848694	1472	NA	FT	VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein localized to COPII-coated vesicles; involved in vesicle formation and incorporation of specific secretory cargo; protein abundance increases in response to DNA replication stress	ER to Golgi vesicle-mediated transport	molecular_function	integral to membrane|ER to Golgi transport vesicle
YNL116W	YNL116W	DMA2	hom	Verified	0.137280883028338	0.4454043902489	no	2017	0.479380546347329	1602	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION			Ubiquitin-protein ligase (E3); controls septin dynamics and the spindle position checkpoint (SPOC) along with functionally redundant ligase Dma1p by regulating the recruitment of Elm1p to the bud neck; regulates levels of the translation initiation factor eIF2 subunit Gcd11p, as well as abundance, localization, and ubiquitination of Cdk inhibitory kinase Swe1p; ortholog of human RNF8 protein, with sequence similarity to human Chfr; contains FHA and RING finger domains	establishment of mitotic spindle orientation|protein autoubiquitination|septin ring assembly|mitotic cell cycle spindle assembly checkpoint	ubiquitin-protein ligase activity	cytoplasm
YML118W	YML118W	NGL3	hom	Verified	0.137140430521653	0.445459897712153	no	2018	0.424735275260823	1368	NA					3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication	polyadenylation-dependent RNA catabolic process	poly(A)-specific ribonuclease activity|endonuclease activity	cellular_component
YDL104C	YDL104C	QRI7	hom	Verified	0.136060223768217	0.44588683593883	no	2019	0.461575192217342	1513	NA	FT	RNA PROCESSING|PROTEOLYSIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Highly conserved mitochondrial protein, essential for t6A modification of mitochondrial tRNAs that decode ANN codons; similar to Kae1p and E. coli YgjD, both of which are also required for tRNA t6A modification	mitochondrial tRNA threonylcarbamoyladenosine modification	molecular_function	mitochondrion
YDL241W_p	YDL241W	YDL241W	hom	Uncharacterized	0.13567805477535	0.446037898513053	no	2020	0.442244441438996	1439	NA					Putative protein of unknown function; YDL241W is not an essential gene	biological_process	molecular_function	cellular_component
YDR458C	YDR458C	HEH2	hom	Verified	0.135146992933621	0.446247827991349	no	2021	0.452541153443319	1489	NA	FT		ENDOMEMBRANE SYSTEM|NUCLEUS		Inner nuclear membrane (INM) protein; contains helix-extension-helix (HEH) motif, nuclear localization signal sequence; targeting to the INM requires the Srp1p-Kap95p karyopherins and the Ran cycle	biological_process	molecular_function	nuclear envelope
YOL112W	YOL112W	MSB4	hom	Verified	0.135086284059009	0.446271827253964	no	2022	0.447294695044759	1477	NA	FT	SIGNALING|NUCLEOTIDE METABOLISM|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH		GTPase-activating protein of the Ras superfamily that acts primarily on Sec4p, localizes to the bud site and bud tip, has similarity to Msb3p; msb3 msb4 double mutation causes defects in secretion and actin organization	actin filament organization	Rab GTPase activator activity	incipient cellular bud site|polarisome|cellular bud tip
YCR091W	YCR091W	KIN82	hom	Verified	0.134471510703046	0.446514868811829	no	2023	0.419559689745446	1407	NA	FT	MEMBRANE ORGANIZATION|PROTEIN PHOSPHORYLATION			Putative serine/threonine protein kinase implicated in the regulation of phospholipid asymmetry through the activation of phospholipid translocases (flippases) Lem3p-Dnf1p/Dnf2p; similar to Fpk1p	phospholipid translocation|protein phosphorylation|response to pheromone	protein kinase activity	cellular_component
YGL216W	YGL216W	KIP3	hom	Verified	0.134389619673651	0.446547244738147	no	2024	0.426354027413668	1406	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CYTOSKELETON ORGANIZATION	NUCLEUS|CYTOSKELETON		Kinesin-related motor protein involved in mitotic spindle positioning	nuclear migration along microtubule|mitotic spindle disassembly|establishment of mitotic spindle orientation|plus-end specific microtubule depolymerization|mitotic spindle organization in nucleus	plus-end-directed microtubule motor activity|tubulin-dependent ATPase activity	kinesin complex|cytoplasmic microtubule|nuclear microtubule
YBL029C-A	YBL029C-A	YBL029C-A	hom	Verified	0.133550446564831	0.4468790354771	no	2025	0.457242043075435	1520	NA	FT		PLASMA MEMBRANE		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; protein abundance increases in response to DNA replication stress; has potential orthologs in Saccharomyces species and in Yarrowia lipolytica	biological_process	molecular_function	plasma membrane
YER060W	YER060W	FCY21	hom	Verified	0.131673981119581	0.447621083177214	no	2026	0.449798801791164	1491	NA					Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function	transmembrane transport	nucleobase transmembrane transporter activity	integral to membrane
YKL213C	YKL213C	DOA1	hom	Verified	0.131653331737635	0.447629249993885	no	2027	0.424761383228121	1376	NA	FT	RESPONSE TO DNA DAMAGE|PROTEOLYSIS	NUCLEUS		WD repeat protein required for ubiquitin-mediated protein degradation; forms a complex with Cdc48p; plays a role in controlling cellular ubiquitin concentration; also promotes efficient NHEJ in postdiauxic/stationary phase; protein increases in abundance and relocalizes from nucleus to nuclear periphery upon DNA replication stress	double-strand break repair via nonhomologous end joining|ubiquitin-dependent protein catabolic process	ubiquitin binding	nucleus|cytoplasm
YDL190C	YDL190C	UFD2	hom	Verified	0.131135298651252	0.447834138987173	no	2028	0.450980773291112	1497	NA	FT	PROTEOLYSIS	NUCLEUS		Ubiquitin chain assembly factor (E4) that cooperates with a ubiquitin-activating enzyme (E1), a ubiquitin-conjugating enzyme (E2), and a ubiquitin protein ligase (E3) to conjugate ubiquitin to substrates; also functions as an E3	ER-associated protein catabolic process|protein ubiquitination|ubiquitin-dependent protein catabolic process|response to stress	ubiquitin-ubiquitin ligase activity	nucleus|cytoplasm
YLR252W_d	YLR252W	YLR252W	hom	Dubious	0.130989680555746	0.447891735394226	no	2029	0.457651415300715	1531	NA					Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene SYM1, a mitochondrial protein involved in ethanol metabolism	Unknown	Unknown	Unknown
YNL146W_p	YNL146W	YNL146W	hom	Uncharacterized	0.130759193137281	0.447982902457431	no	2030	0.459707989274935	1510	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YNL146W is not an essential gene	biological_process	molecular_function	endoplasmic reticulum
YLL049W	YLL049W	LDB18	hom	Verified	0.129782716961564	0.448369168560937	no	2031	0.436118590981515	1409	NA	FT	CELL CYCLE|CYTOSKELETON ORGANIZATION	CYTOSKELETON		Component of the dynactin complex, which is required for dynein activity; null mutant exhibits defects in nuclear migration and spindle orientation and has reduced affinity for alcian blue dye; has homology to mammalian dynactin subunit p24	establishment of mitotic spindle orientation	molecular_function	dynactin complex|cell cortex|spindle pole body|astral microtubule
YBR284W_p	YBR284W	YBR284W	hom	Uncharacterized	0.129632946580374	0.44842841778798	no	2032	0.451443626855345	1505	NA	FT	NUCLEOTIDE METABOLISM			Putative metallo-dependent hydrolase superfamily protein; similar to AMP deaminases but lacks key catalytic residues and does not rescue purine nucleotide metabolic defect of quadruple aah1 ade8 amd1 his1 mutant; null mutant exhibits longer telomeres, altered Ty mobility, decreased resistance to rapamycin and wortmannin; induced in response to hydrostatic pressure; not an essential gene; YBR284W has a paralog, YJL070C, that arose from the whole genome duplication	biological_process	AMP deaminase activity|molecular_function	cellular_component
YMR174C	YMR174C	PAI3	hom	Verified	0.128769791578261	0.448769904655441	no	2033	0.444672097177892	1485	NA					Cytoplasmic proteinase A (Pep4p) inhibitor, dependent on Pbs2p and Hog1p protein kinases for osmotic induction; intrinsically unstructured, N-terminal half becomes ordered in the active site of proteinase A upon contact	vacuolar protein catabolic process	endopeptidase inhibitor activity	cytoplasm
YGR292W	YGR292W	MAL12	hom	Verified	0.128005099871887	0.449072468565815	no	2034	0.441032149171676	1447	NA	FT	CARBOHYDRATE METABOLISM			Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL1 complex locus; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose	sucrose catabolic process|maltose catabolic process	sucrose alpha-glucosidase activity|maltose alpha-glucosidase activity	plasma membrane
YMR283C	YMR283C	RIT1	hom	Verified	0.127388613274912	0.449316414053568	no	2035	0.412834504545864	1370	NA	FT	RNA PROCESSING			2'-O-ribosyl phosphate transferase, modifies the initiator methionine tRNA at position 64 to distinguish it from elongator methionine tRNA	charged-tRNA amino acid modification	transferase activity, transferring pentosyl groups	cytoplasm
YJR032W	YJR032W	CPR7	hom	Verified	0.126958490551858	0.449486626181999	no	2036	0.457454283881756	1518	NA					Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity	protein refolding|response to stress	unfolded protein binding|peptidyl-prolyl cis-trans isomerase activity	cytosol
YBR138C_p	YBR138C	YBR138C	hom	Uncharacterized	0.126815432441042	0.449543240517612	no	2037	0.406819865709467	1363	NA					Cytoplasmic protein of unknown function, potentially phosphorylated by Cdc28p; YBR138C is not an essential gene	biological_process	molecular_function	cytoplasm
YCR030C	YCR030C	SYP1	hom	Verified	0.126203297346263	0.449785500666213	no	2038	0.433909805722126	1401	NA	FT	CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH		Protein of unknown function that is involved in endocytic site formation; may regulate assembly and disassembly of the septin ring; colocalizes and interacts with septin subunits; potential role in actin cytoskeletal organization	septin cytoskeleton organization|actin cortical patch assembly	molecular_function	mating projection base|mating projection tip|cellular bud neck|cellular bud tip
YFR010W	YFR010W	UBP6	hom	Verified	0.125943409625921	0.449888360159254	no	2039	0.461181872673691	1522	NA	FT	PROTEOLYSIS			Ubiquitin-specific protease situated in the base subcomplex of the 26S proteasome, releases free ubiquitin from branched polyubiquitin chains; works in opposition to Hul5p polyubiquitin elongation activity; mutant has aneuploidy tolerance	protein deubiquitination	ubiquitin-specific protease activity	proteasome complex|proteasome regulatory particle
YPR200C	YPR200C	ARR2	hom	Verified	0.125406038339202	0.450101053976023	no	2040	0.44973582609546	1479	NA					Arsenate reductase required for arsenate resistance; converts arsenate to arsenite which can then be exported from cells by Arr3p	response to arsenic-containing substance	arsenate reductase activity	cellular_component
YDL118W_d	YDL118W	YDL118W	hom	Dubious	0.125097382342796	0.450223227803241	no	2041	0.460978782698712	1523	NA	FF|FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Dubious open reading frame, unlikely to encode a protein; overlaps almost completely with YDL119C; mutations that would affect both YDL118W and YDL119C confer defective telomere maintenance and are synthetically sick or lethal with alpha-synuclein	biological_process	molecular_function	cellular_component
YMR009W	YMR009W	ADI1	hom	Verified	0.124515461501124	0.450453579569493	no	2042	0.440571688580873	1458	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS	NUCLEUS		Acireductone dioxygenease involved in the methionine salvage pathway; ortholog of human MTCBP-1; transcribed as polycistronic mRNA with YMR010W and regulated post-transcriptionally by RNase III (Rnt1p) cleavage; ADI1 mRNA is induced in heat shock conditions	L-methionine salvage from methylthioadenosine	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	nucleus|cytoplasm
YGR261C	YGR261C	APL6	hom	Verified	0.124204846187985	0.450576542625206	no	2043	0.468752026876876	1568	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Beta3-like subunit of the yeast AP-3 complex; functions in transport of alkaline phosphatase to the vacuole via the alternate pathway; exists in both cytosolic and peripherally associated membrane-bound pools	vesicle-mediated transport|Golgi to vacuole transport	molecular_function	AP-3 adaptor complex
YDL080C	YDL080C	THI3	hom	Verified	0.124068983455737	0.450630327997167	no	2044	0.450118257315878	1497	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Probable alpha-ketoisocaproate decarboxylase, may have a role in catabolism of amino acids to long-chain and complex alcohols; required for expression of enzymes involved in thiamine biosynthesis	regulation of thiamine biosynthetic process|branched-chain amino acid catabolic process to alcohol via Ehrlich pathway|positive regulation of transcription from RNA polymerase II promoter|leucine catabolic process	carboxy-lyase activity	cytosol|nucleus
YAL030W	YAL030W	SNC1	hom	Verified	0.12395018267109	0.450677359624131	no	2045	0.44630999414848	1484	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Vesicle membrane receptor protein (v-SNARE); involved in the fusion between Golgi-derived secretory vesicles with the plasma membrane; proposed to be involved in endocytosis; member of the synaptobrevin/VAMP family of R-type v-SNARE proteins; SNC1 has a paralog, SNC2, that arose from the whole genome duplication	endocytosis|exocytosis|Golgi to plasma membrane transport|vesicle fusion	SNAP receptor activity	SNARE complex|trans-Golgi network|endosome|transport vesicle membrane|plasma membrane|cellular bud neck
YGR213C	YGR213C	RTA1	hom	Verified	0.121733393027728	0.451555083045659	no	2046	0.433328920660252	1437	NA	FT		PLASMA MEMBRANE		Protein involved in 7-aminocholesterol resistance; has seven potential membrane-spanning regions; expression is induced under both low-heme and low-oxygen conditions; member of the fungal lipid-translocating exporter (LTE) family of protein	biological_process	molecular_function	integral to membrane|plasma membrane
YHR086W	YHR086W	NAM8	hom	Verified	0.121474096664163	0.451657765308859	no	2047	0.462903367020271	1530	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING	NUCLEUS|MITOCHONDRION		RNA binding protein, component of the U1 snRNP protein; mutants are defective in meiotic recombination and in formation of viable spores, involved in the formation of DSBs through meiosis-specific splicing of REC107 pre-mRNA; Nam8p regulon embraces the meiotic pre-mRNAs of REC107, HFM1, AMA1 SPO22 and PCH2; the putative RNA binding domains RRM2 and RRM3 are required for Nam8p meiotic function	mRNA splicing, via spliceosome|positive regulation of mRNA splicing, via spliceosome|mRNA splice site selection	mRNA binding|RNA binding	commitment complex|U1 snRNP|U2-type prespliceosome
YPL147W	YPL147W	PXA1	hom	Verified	0.120110884332498	0.452197655181801	no	2048	0.450567424488366	1469	NA	FT	NUCLEOTIDE METABOLISM			Subunit of a heterodimeric peroxisomal ATP-binding cassette transporter complex (Pxa1p-Pxa2p), required for import of long-chain fatty acids into peroxisomes; similarity to human adrenoleukodystrophy transporter ABCD1 and ABCD2 and ALD-related proteins; mutations in ABCD1 cause X-linked adrenoleukodystrophy (X-ALD), a peroxisomal disorder	fatty acid transport	ATPase activity, coupled to transmembrane movement of substances	integral to membrane|integral to peroxisomal membrane
YNL304W	YNL304W	YPT11	hom	Verified	0.119848656372845	0.452301518739418	no	2049	0.461754870447639	1544	NA	FT	SIGNALING|MITOCHONDRION ORGANIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|SITE OF POLARIZED GROWTH		Rab family GTPase that interacts with the C-terminal tail domain of Myo2p; mediates distribution of mitochondria and endoplasmic reticuli to daughter cells	mitochondrion inheritance|endoplasmic reticulum inheritance|Golgi inheritance|Golgi localization	GTPase activity	incipient cellular bud site|endoplasmic reticulum|cellular bud neck|cellular bud tip
YBL107C	YBL107C	MIC23	hom	Verified	0.119745435013611	0.452342403672106	no	2050	0.443230326052969	1460	NA					Mitochondrial intermembrane space protein of unknown function; imported via the MIA import machinery; contains an unusual twin cysteine motif (CX13C CX14C)	biological_process	molecular_function	cytoplasm
YBL071C-B_p	YBL071C-B	YBL071C-B	hom	Uncharacterized	0.119086514615208	0.452603407245176	no	2051	0.459221606351778	1523	NA					Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching	biological_process	molecular_function	cellular_component
YDR165W	YDR165W	TRM82	hom	Verified	0.118948812145724	0.452657954871812	no	2052	0.47945360949183	1597	NA	FT	RNA PROCESSING	NUCLEUS		Catalytic subunit of a tRNA methyltransferase complex; Trm8p and Trm82p comprise an enzyme that catalyzes a methyl-transfer from S-adenosyl-l-methionine to the N(7) atom of guanine at position 46 in tRNA; Trm8 lacks catalytic activity if not bound to Trm82p	tRNA methylation	tRNA (guanine-N7-)-methyltransferase activity	tRNA methyltransferase complex|nucleus
YGL221C	YGL221C	NIF3	hom	Verified	0.118651139422098	0.452775874041389	no	2053	0.455551520030542	1505	NA	FT		MITOCHONDRION		Protein of unknown function, similar to Listeria monocytogenes major sigma factor (rpoD gene product); the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion|cytoplasm
YGR227W	YGR227W	DIE2	hom	Verified	0.118582304676027	0.45280314262213	no	2054	0.452564544170593	1511	NA	FT	CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Dolichyl-phosphoglucose-dependent alpha-1,2 glucosyltransferase of the ER, functions in the pathway that synthesizes the dolichol-linked oligosaccharide precursor for N-linked protein glycosylation, has a role in regulation of ITR1 and INO1	dolichol-linked oligosaccharide biosynthetic process|protein N-linked glycosylation	dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity	integral to membrane|endoplasmic reticulum membrane
YLR350W	YLR350W	ORM2	hom	Verified	0.118025417434666	0.453023759217541	no	2055	0.451937527060297	1490	NA	FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Evolutionarily conserved protein, similar to Orm1p; required for resistance to agents that induce unfolded protein response; Orm1p and Orm2p together control membrane biogenesis by coordinating lipid homeostasis with protein quality control; protein abundance increases in response to DNA replication stress	cellular sphingolipid homeostasis|negative regulation of sphingolipid biosynthetic process|response to unfolded protein	molecular_function	integral to membrane|endoplasmic reticulum|SPOTS complex
YDR334W	YDR334W	SWR1	hom	Verified	0.117445999394943	0.453253317011772	no	2056	0.463452010703832	1521	NA	FF|FT	CHROMATIN ORGANIZATION	NUCLEUS|CHROMOSOME		Swi2/Snf2-related ATPase that is the structural component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A	chromatin remodeling|histone exchange	structural molecule activity	Swr1 complex|nucleus
YPL247C_p	YPL247C	YPL247C	hom	Uncharacterized	0.115990202164497	0.453830153461176	no	2057	0.431964059196224	1405	NA	FT		NUCLEUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; similar to the petunia WD repeat protein an11; overexpression causes a cell cycle delay or arrest	biological_process	molecular_function	nucleus|cytoplasm
YGR283C	YGR283C	YGR283C	hom	Verified	0.115786728865479	0.453910784299386	no	2058	0.452095235634544	1512	NA	FT		NUCLEUS		Putative S-adenosylmethionine-dependent methyltransferase; may interact with ribosomes, based on co-purification experiments; predicted to be involved in ribosome biogenesis; null mutant is resistant to fluconazole; GFP-fusion protein localizes to the nucleolus	biological_process	S-adenosylmethionine-dependent methyltransferase activity	ribosome|nucleolus
YCR031C	YCR031C	RPS14A	hom	Verified	0.115589217659211	0.453989054342209	no	2059	0.45647927427324	1508	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION	NUCLEUS	RIBOSOME	Protein component of the small (40S) ribosomal subunit; required for ribosome assembly and 20S pre-rRNA processing; mutations confer cryptopleurine resistance; homologous to mammalian ribosomal protein S14 and bacterial S11; RPS14A has a paralog, RPS14B, that arose from the whole genome duplication	cytoplasmic translation|ribosomal small subunit assembly|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome|mRNA binding	small-subunit processome|cytosolic small ribosomal subunit|90S preribosome
YNL042W	YNL042W	BOP3	hom	Verified	0.115277729137971	0.454112495119755	no	2060	0.438405855760431	1444	NA	FT		NUCLEUS		Protein of unknown function, potential Cdc28p substrate; overproduction confers resistance to methylmercury	cellular response to methylmercury	molecular_function	nucleus|cytoplasm
YBR085W	YBR085W	AAC3	hom	Verified	0.114831487866229	0.454289345214417	no	2061	0.451751274551887	1507	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Mitochondrial inner membrane ADP/ATP translocator; exchanges cytosolic ADP for mitochondrially synthesized ATP; expressed under anaerobic conditions; similar to Aac1p; has roles in maintenance of viability and in respiration; AAC3 has a paralog, PET9, that arose from the whole genome duplication	heme biosynthetic process|heme transport|anaerobic respiration|transmembrane transport	ATP:ADP antiporter activity	mitochondrion|integral to membrane|mitochondrial inner membrane
YER065C	YER065C	ICL1	hom	Verified	0.114824957463352	0.454291933348913	no	2062	0.41536176228089	1362	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM			Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose	glyoxylate cycle	isocitrate lyase activity	cellular_component
YDR360W_d	YDR360W	OPI7	hom	Dubious	0.114215475457919	0.45453349227327	no	2063	0.451350733097799	1486	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene VID21/YDR359C.	Unknown	Unknown	Unknown
YJR038C_d	YJR038C	YJR038C	hom	Dubious	0.113240717717015	0.454919857597226	no	2064	0.454925797209504	1523	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YBR108W	YBR108W	AIM3	hom	Verified	0.11266381887243	0.455148543460133	no	2065	0.462696210675443	1523	NA	FT	CYTOSKELETON ORGANIZATION	CYTOSKELETON		Protein interacting with Rvs167p; null mutant is viable and displays elevated frequency of mitochondrial genome loss	actin cortical patch assembly	molecular_function	membrane raft|actin cortical patch
YBR186W	YBR186W	PCH2	hom	Verified	0.111678649371673	0.455539104372362	no	2066	0.43727947927004	1445	NA	FT	CELL CYCLE	NUCLEUS|CHROMOSOME		Nucleolar component of the pachytene checkpoint, which prevents chromosome segregation when recombination and chromosome synapsis are defective; also represses meiotic interhomolog recombination in the rDNA; required for meiotic double-stranded break formation	meiotic recombination checkpoint|meiotic DNA double-strand break formation|reciprocal meiotic recombination	ATPase activity	nucleolus
YGR212W	YGR212W	SLI1	hom	Verified	0.111576120057584	0.455579753601754	no	2067	0.465896820195041	1567	NA	FT		ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|PLASMA MEMBRANE		N-acetyltransferase, confers resistance to the sphingolipid biosynthesis inhibitor myriocin (ISP-1) by converting it into N-acetyl-myriocin, co-operates with Ypk1p in mediating resistance to myriocin	response to drug	N-acetyltransferase activity	nuclear envelope|plasma membrane
YAL044C	YAL044C	GCV3	hom	Verified	0.110955878274332	0.455825667327159	no	2068	0.470009773381059	1563	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		H subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; also required for all protein lipoylation; expression is regulated by levels of 5,10-methylene-THF	glycine catabolic process|one-carbon metabolic process|protein lipoylation	glycine dehydrogenase (decarboxylating) activity	mitochondrion|glycine cleavage complex
YJL200C	YJL200C	ACO2	hom	Verified	0.110812273101632	0.455882606383246	no	2069	0.428296142885035	1388	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Putative mitochondrial aconitase isozyme; similarity to Aco1p, an aconitase required for the TCA cycle; expression induced during growth on glucose, by amino acid starvation via Gcn4p, and repressed on ethanol	biological_process	aconitate hydratase activity	mitochondrion
YLR363W-A	YLR363W-A	YLR363W-A	hom	Verified	0.110694898072611	0.455929145932498	no	2070	0.429402110246131	1408	NA	FT		NUCLEUS		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; relocalizes from nucleus to nucleolus upon DNA replication stress	biological_process	molecular_function	nucleus
YDR264C	YDR264C	AKR1	hom	Verified	0.110468773102083	0.456018806862112	no	2071	0.423245235420989	1947	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Palmitoyl transferase involved in protein palmitoylation; acts as a negative regulator of pheromone response pathway; required for endocytosis of pheromone receptors; involved in cell shape control; contains ankyrin repeats; AKR1 has a paralog, AKR2, that arose from the whole genome duplication	protein targeting to membrane|regulation of endocytosis|regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion|protein palmitoylation	palmitoyltransferase activity	integral to membrane|Golgi apparatus|membrane
YDR423C	YDR423C	CAD1	hom	Verified	0.109977165080291	0.456213742336001	no	2072	0.468728212209865	1560	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		AP-1-like basic leucine zipper (bZIP) transcriptional activator; involved in stress responses, iron metabolism, and pleiotropic drug resistance; controls a set of genes involved in stabilizing proteins; binds consensus sequence TTACTAA; CAD1 has a paralog, YAP1, that arose from the whole genome duplication	cellular response to cadmium ion|positive regulation of transcription from RNA polymerase II promoter in response to stress|positive regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus|cytoplasm
YPL104W	YPL104W	MSD1	hom	Verified	0.109104199801159	0.456559921909168	no	2073	0.465367444605213	1547	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial aspartyl-tRNA synthetase, required for acylation of aspartyl-tRNA; yeast and bacterial aspartyl-, asparaginyl-, and lysyl-tRNA synthetases contain regions with high sequence similarity, suggesting a common ancestral gene	mitochondrial aspartyl-tRNA aminoacylation	aspartate-tRNA ligase activity	mitochondrion
YJL058C	YJL058C	BIT61	hom	Verified	0.107892547592412	0.457040464386456	no	2074	0.451532811226634	1504	NA	FT	SIGNALING|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION	PLASMA MEMBRANE		Subunit of TORC2 membrane-associated complex; involved in regulation of cell cycle-dependent actin cytoskeletal dynamics during polarized growth and cell wall integrity; BIT61 has a paralog, BIT2, that arose from the whole genome duplication	fungal-type cell wall organization|TOR signaling cascade|regulation of cell growth|establishment or maintenance of actin cytoskeleton polarity	molecular_function	TORC2 complex|plasma membrane|cytoplasm
YCR067C	YCR067C	SED4	hom	Verified	0.107667555144849	0.457129703553017	no	2075	0.456125163223569	1494	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|NUCLEOTIDE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Integral endoplasmic reticulum membrane protein that stimulates Sar1p GTPase activity; involved in COPII vesicle budding through disassociation of coat proteins from membranes onto liposomes; binds Sec16p; similar to Sec12p	positive regulation of GTPase activity|regulation of COPII vesicle coating	Sar GTPase activator activity	integral to endoplasmic reticulum membrane
YHR155W	YHR155W	YSP1	hom	Verified	0.107284047275303	0.457281819962219	no	2076	0.465184960193663	1534	NA	FF|FT		MITOCHONDRION		Mitochondrial protein; potential role in promoting mitochondrial fragmentation during programmed cell death in response to high levels of alpha-factor mating pheromone or the drug amiodarone; YSP1 has a paralog, SIP3, that arose from the whole genome duplication	biological_process	molecular_function	mitochondrion
YDR231C	YDR231C	COX20	hom	Verified	0.107256258437653	0.45729284250413	no	2077	0.459033168261496	1510	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase	mitochondrial respiratory chain complex IV assembly|protein processing|aerobic respiration	unfolded protein binding	mitochondrion|mitochondrial inner membrane
YDL041W_d	YDL041W	YDL041W	hom	Dubious	0.107184012818236	0.457321499141354	no	2078	0.46902442383837	1571	NA	FF				Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene SIR2/YDL042C	Unknown	Unknown	Unknown
YOR297C	YOR297C	TIM18	hom	Verified	0.107126780368429	0.457344200876711	no	2079	0.454385050661344	1501	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS	MITOCHONDRION		Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; may mediate assembly or stability of the complex	cellular response to oxidative stress|protein import into mitochondrial inner membrane|apoptotic process|response to acid|response to osmotic stress|response to arsenic-containing substance	protein channel activity	mitochondrion|integral to membrane|mitochondrial inner membrane protein insertion complex
YDR484W	YDR484W	VPS52	hom	Verified	0.106045127457547	0.457773273744286	no	2080	0.477538522859333	1577	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	GOLGI APPARATUS|CYTOSKELETON		Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; involved in localization of actin and chitin	actin filament-based process|Golgi to vacuole transport|retrograde transport, endosome to Golgi	protein binding	Golgi apparatus|GARP complex
YJL159W	YJL159W	HSP150	hom	Verified	0.105453804779338	0.458007861990324	no	2081	0.446780708616053	1474	NA	FT	CELL WALL ORG/BIOGENESIS			O-mannosylated heat shock protein; secreted and covalently attached to the cell wall via beta-1,3-glucan and disulfide bridges; required for cell wall stability; induced by heat shock, oxidative stress, and nitrogen limitation; HSP150 has a paralog, PIR3, that arose from the whole genome duplication	fungal-type cell wall organization	structural constituent of cell wall|ATPase activity	fungal-type cell wall|extracellular region
YDR076W	YDR076W	RAD55	hom	Verified	0.10530518500993	0.458066824405387	no	2082	0.483788309524004	1607	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS		Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad57p	DNA recombinase assembly|heteroduplex formation|meiotic DNA recombinase assembly|double-strand break repair via single-strand annealing	DNA-dependent ATPase activity|protein heterodimerization activity	nucleus|Rhp55-Rhp57 complex
YNL140C_p	YNL140C	YNL140C	hom	Uncharacterized	0.105120983049174	0.458139904741983	no	2083	0.498810964148233	1684	NA					Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps THO2/YNL139C	biological_process	molecular_function	cellular_component
YDL213C	YDL213C	NOP6	hom	Verified	0.10484366657539	0.458249930024233	no	2084	0.457327932059812	1504	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		rRNA-binding protein required for 40S ribosomal subunit biogenesis; contains an RNA recognition motif (RRM); hydrophilin essential to overcome the stress of the desiccation-rehydration process; NOP6 may be a fungal-specific gene as no homologs have been yet identified in higher eukaryotes	ribosomal small subunit biogenesis	RNA binding|rRNA binding	nucleolus|90S preribosome
YOR188W	YOR188W	MSB1	hom	Verified	0.104186427043949	0.458510702500097	no	2085	0.497975758279227	1673	NA	FT		MITOCHONDRION|SITE OF POLARIZED GROWTH		Protein of unknown function; may be involved in positive regulation of 1,3-beta-glucan synthesis and the Pkc1p-MAPK pathway; multicopy suppressor of temperature-sensitive mutations in CDC24 and CDC42, and of mutations in BEM4; potential Cdc28p substrate; relocalizes from bud neck to cytoplasm upon DNA replication stress	establishment of cell polarity	molecular_function	mitochondrion|cellular bud neck|cellular bud tip
YFR014C	YFR014C	CMK1	hom	Verified	0.103898601067513	0.458624908643402	no	2086	0.454794774303048	1500	NA	FT	SIGNALING|PROTEIN PHOSPHORYLATION			Calmodulin-dependent protein kinase; may play a role in stress response, many Ca++/calmodulin dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to mammalian Cam Kinase II; CMK1 has a paralog, CMK2, that arose from the whole genome duplication	signal transduction|protein phosphorylation	protein kinase activity|calmodulin-dependent protein kinase activity	cytoplasm
YJL193W_p	YJL193W	YJL193W	hom	Uncharacterized	0.103452535301523	0.458801909318273	no	2087	0.462945803014021	1528	NA					Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect	biological_process	molecular_function	integral to membrane
YDL156W	YDL156W	CMR1	hom	Verified	0.102789534233513	0.459065005868471	no	2088	0.467507139534206	1563	NA	FT		NUCLEUS|CHROMOSOME		DNA-binding protein with preference for UV-damaged DNA; protein sequence contains three WD domains (WD-40 repeat); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; potential regulatory target of Mbp1p, which binds to the promoter region; co-localizes with Hos2p in nuclear foci in response to DNA damage by MMS	biological_process	DNA binding	nuclear chromatin|nucleus|cytoplasm
YDL091C	YDL091C	UBX3	hom	Verified	0.102713618837611	0.459095132273531	no	2089	0.465070718338868	1517	NA					Subunit of the DSC ubiquitin ligase complex; UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; ortholog of fission yeast Ucp10	biological_process	molecular_function	cytoplasm
YOR228C	YOR228C	YOR228C	hom	Verified	0.101381037224565	0.459623994505682	no	2090	0.469263429134653	1560	NA	FT		MITOCHONDRION		Protein of unknown function, localized to the mitochondrial outer membrane	biological_process	molecular_function	mitochondrial outer membrane|mitochondrion|integral to membrane
YGL080W	YGL080W	FMP37	hom	Verified	0.0990210967945455	0.460560759801685	no	2091	0.463975298223582	1542	NA	FT		MITOCHONDRION		Highly conserved subunit of the mitochondrial pyruvate carrier; a mitochondrial inner membrane complex comprised of Fmp37p/Mpc1p and either Mpc2p or Fmp43p/Mpc3p mediates mitochondrial pyruvate uptake; null mutant displays slow growth that is complemented by expression of human or mouse ortholog; mutation in human ortholog is associated with lactic acidosis and hyperpyruvatemia	mitochondrial pyruvate transport	pyruvate transmembrane transporter activity	mitochondrion|integral to mitochondrial inner membrane
YOL004W	YOL004W	SIN3	hom	Verified	0.0988484257823545	0.460629309262642	no	2092	0.464612242053815	1528	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|CELL DIVISION|GENE SILENCING	NUCLEUS|CHROMOSOME		Component of the Sin3p-Rpd3p histone deacetylase complex, involved in transcriptional repression and activation of diverse processes, including mating-type switching and meiosis; involved in the maintenance of chromosomal integrity	positive regulation of transcription from RNA polymerase II promoter in response to heat stress|negative regulation of chromatin silencing at rDNA|histone deacetylation|negative regulation of chromatin silencing at silent mating-type cassette|negative regulation of transcription from RNA polymerase I promoter|negative regulation of transcription during meiosis|regulation of DNA-dependent DNA replication initiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of chromatin silencing at telomere|double-strand break repair via nonhomologous end joining|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription involved in G2/M-phase of mitotic cell cycle	transcription coactivator activity|transcription corepressor activity	Sin3-type complex|Rpd3S complex|Rpd3L-Expanded complex|Rpd3L complex
YOR258W	YOR258W	HNT3	hom	Verified	0.0985881861850522	0.460732625189699	no	2093	0.468474680874352	1557	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		DNA 5' AMP hydrolase involved in DNA repair; member of the histidine triad (HIT) superfamily of nucleotide-binding proteins; homolog of Aprataxin, a Hint related protein that is mutated in individuals with ataxia with oculomotor apraxia; relative distribution to nuclear foci decreases upon DNA replication stress	response to DNA damage stimulus	DNA 5'-adenosine monophosphate hydrolase activity	nucleus|cytoplasm
YOL019W-A_p	YOL019W-A	YOL019W-A	hom	Uncharacterized	0.0985088319896628	0.460764129579023	no	2094	0.470135982406989	1567	NA					Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching	biological_process	molecular_function	cellular_component
YNL096C	YNL096C	RPS7B	hom	Verified	0.0981953402930478	0.460888591245655	no	2095	0.46079166454951	1545	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION	NUCLEUS	RIBOSOME	Protein component of the small (40S) ribosomal subunit; interacts with Kti11p; deletion causes hypersensitivity to zymocin; homologous to mammalian ribosomal protein S7, no bacterial homolog; RPS7B has a paralog, RPS7A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress	cytoplasmic translation|ribosome biogenesis	structural constituent of ribosome	small-subunit processome|cytosolic small ribosomal subunit
YOR197W	YOR197W	MCA1	hom	Verified	0.0980612308318255	0.460941836209643	no	2096	0.459651846575347	1523	NA	FT	PROTEOLYSIS	NUCLEUS		Ca2+-dependent cysteine protease; may cleave specific substrates during the stress response; regulates apoptosis upon H2O2 treatment; required for clearance of insoluble protein aggregates during normal growth; implicated in cell cycle dynamics; undergoes autocatalytic processing; similar to mammalian metacaspases, but exists as a monomer due to an extra pair of anti-parallel beta-strands that form a continuous beta-sheet, blocking potential dimerization	misfolded or incompletely synthesized protein catabolic process|apoptotic process	cysteine-type peptidase activity	nucleus
YMR262W_p	YMR262W	YMR262W	hom	Uncharacterized	0.0961923533297682	0.461683901906218	no	2097	0.456072394653071	1510	NA					Protein of unknown function; interacts weakly with Knr4p; YMR262W is not an essential gene	biological_process	molecular_function	cellular_component
YDR319C_p	YDR319C	YFT2	hom	Uncharacterized	0.0957393853400303	0.4618637797895	no	2098	0.455928533891472	1531	NA					Protein required for normal ER membrane biosynthesis; member of the highly conserved FIT family of proteins involved in triglyceride droplet biosynthesis and homologous to human FIT2; interacts with Sst2p and Hsp82p in high-throughput two-hybrid screens	biological_process	molecular_function	integral to membrane
YBR035C	YBR035C	PDX3	hom	Verified	0.0945523309741264	0.46233520724728	no	2099	0.464550150919419	1551	NA	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM			Pyridoxine (pyridoxamine) phosphate oxidase, has homologs in E. coli and Myxococcus xanthus; transcription is under the general control of nitrogen metabolism	fatty acid metabolic process	pyridoxamine-phosphate oxidase activity	cellular_component
YGR197C	YGR197C	SNG1	hom	Verified	0.0932264909965982	0.46286181462987	no	2100	0.459807665024552	1523	NA	FT		PLASMA MEMBRANE		Protein involved in resistance to nitrosoguanidine (MNNG) and 6-azauracil (6-AU); expression is regulated by transcription factors involved in multidrug resistance	nucleobase-containing compound transport	molecular_function	integral to membrane|plasma membrane
YKR017C	YKR017C	HEL1	hom	Verified	0.0927470080319128	0.463052275459742	no	2101	0.474428197100407	1571	NA					RING finger ubiquitin ligase (E3); involved in ubiquitylation and degradation of excess histones; interacts with Ubc4p and Rad53p; null mutant sensitive to hydroxyurea (HU)	biological_process	molecular_function	cellular_component
YOR085W	YOR085W	OST3	hom	Verified	0.0926939361583838	0.463073357257926	no	2102	0.460678181942296	1512	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Gamma subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; Ost3p is important for N-glycosylation of a subset of proteins	protein glycosylation|protein complex assembly|protein O-linked mannosylation|protein N-linked glycosylation	dolichyl-diphosphooligosaccharide-protein glycotransferase activity	oligosaccharyltransferase complex|integral to membrane
YHR057C	YHR057C	CPR2	hom	Verified	0.092425657436598	0.463179927493056	no	2103	0.444716183539201	1500	NA					Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; has a potential role in the secretory pathway	biological_process	peptidyl-prolyl cis-trans isomerase activity	cellular_component
YNL212W	YNL212W	VID27	hom	Verified	0.0918327310385502	0.463415469160915	no	2104	0.462261909026157	1508	NA					Cytoplasmic protein of unknown function; possibly involved in vacuolar protein degradation; not essential for proteasome-dependent degradation of fructose-1,6-bisphosphatase (FBPase); null mutants exhibit normal growth	biological_process	molecular_function	cytoplasm
YLR451W	YLR451W	LEU3	hom	Verified	0.0916736075037183	0.463478683615886	no	2105	0.465035681623065	1530	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Zinc-knuckle transcription factor, repressor and activator; regulates genes involved in branched chain amino acid biosynthesis and ammonia assimilation; acts as a repressor in leucine-replete conditions and as an activator in the presence of alpha-isopropylmalate, an intermediate in leucine biosynthesis that accumulates during leucine starvation	negative regulation of transcription from RNA polymerase II promoter|Unknown|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YDR094W_d	YDR094W	YDR094W	hom	Dubious	0.0913067190702155	0.463624439623379	no	2106	0.457105162992818	1508	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF DNF2	Unknown	Unknown	Unknown
YOR239W	YOR239W	ABP140	hom	Verified	0.0906561512683986	0.463882906658309	no	2107	0.466140511465017	1562	NA	FT	RNA PROCESSING|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		AdoMet-dependent tRNA methyltransferase and actin binding protein; C-terminal domain is responsible for 3-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA-Thr and tRNA-Ser and contains an S-adenosylmethionine (AdoMet) binding motif; N-terminal actin binding sequence interacts with actin filaments and localizes to actin patches and cables; N- and C-terminal domains are encoded in separate ORFs that are translated into one protein via a +1 frameshift	actin filament bundle assembly|tRNA methylation	tRNA (cytosine-3-)-methyltransferase activity|actin filament binding|protein binding, bridging	actin filament|actin filament bundle|mating projection tip|actin cortical patch
YML057C-A_d	YML057C-A	YML057C-A	hom	Dubious	0.0880816582795929	0.464905887142183	no	2108	0.451173688381142	1490	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene CMP2/YML057W	Unknown	Unknown	Unknown
YLR261C_d	YLR261C	VPS63	hom	Dubious	0.087479354863007	0.465145247472726	no	2109	0.499266318379451	1674	NA	FF				Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene YPT6; deletion causes a vacuolar protein sorting defect	Unknown	Unknown	Unknown
YDR312W	YDR312W	SSF2	hom	Verified	0.0859338225083156	0.465759512237311	no	2110	0.443997726700956	1468	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS	NUCLEUS		Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication	conjugation with cellular fusion|ribosomal large subunit assembly	rRNA binding	nucleolus
YJL187C	YJL187C	SWE1	hom	Verified	0.0858464918981402	0.465794223837842	no	2111	0.454207673862446	1492	NA	FT	CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION	NUCLEUS|SITE OF POLARIZED GROWTH		Protein kinase that regulates the G2/M transition by inhibition of Cdc28p kinase activity; localizes to the nucleus and to the daughter side of the mother-bud neck; homolog of S. pombe Wee1p; potential Cdc28p substrate	negative regulation of spindle pole body separation|G2/M transition size control checkpoint|protein phosphorylation|re-entry into mitotic cell cycle|G2/M transition of mitotic cell cycle|cell shape checkpoint|regulation of cyclin-dependent p