strainid	orf	gene	zyg	qualifier	SGTC_865|0488-0499.score	SGTC_865|0488-0499.expt.zyg.pval	SGTC_865|0488-0499.expt.zyg.significant	SGTC_865|0488-0499.expt.zyg.rank	strain.pval	strain.rank	clearance	Fclass	Fterms.BP	Fterms.CC	Fterms.complex	description	GO_process	GO_function	GO_component
YNL324W_d	YNL324W	YNL324W	hom	Dubious	13.7452014536034	2.72106817090126e-43	yes	1	1.4298260716585e-34	2	NA					Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YNL325C	YNL325C	FIG4	hom	Verified	7.76987793656471	3.92808980931366e-15	yes	2	8.36280501675922e-14	1	NA	FT	LIPID METABOLISM			Phosphatidylinositol 3,5-bisphosphate (PtdIns[3,5]P) phosphatase; required for efficient mating and response to osmotic shock; physically associates with and regulated by Vac14p; contains a SAC1-like domain	phosphatidylinositol dephosphorylation	phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity	fungal-type vacuole membrane|PAS complex|extrinsic to membrane
YCL047C	YCL047C	POF1	hom	Verified	7.67992210898598	7.95926742759636e-15	yes	3	2.14854813284163e-13	1	NA	FT	PROTEOLYSIS			ATPase involved in the protein quality control and filamentation pathways; interacts physically with Kss1p and suppresses the filamentation defect of a kss1 deletion; also interacts with Ubc7p	pseudohyphal growth|ER-associated protein catabolic process|invasive growth in response to glucose limitation	ATPase activity	cellular_component
YCL002C_p	YCL002C	YCL002C	hom	Uncharacterized	6.2720954630836	1.78110525976994e-10	yes	4	1.21198316343906e-10	2	NA					Putative protein of unknown function; YCL002C is not an essential gene	biological_process	molecular_function	integral to membrane
YKL064W	YKL064W	MNR2	hom	Verified	5.34089669536181	4.62439761545426e-08	yes	5	1.16596901523673e-08	2	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Vacuolar membrane protein required for magnesium homeostasis; putative magnesium transporter; has similarity to Alr1p and Alr2p, which mediate influx of Mg2+ and other divalent cations	cellular magnesium ion homeostasis	magnesium ion transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane
YBR138C_p	YBR138C	YBR138C	hom	Uncharacterized	5.30692861086046	5.57439080135581e-08	yes	6	2.85515914039428e-09	5	NA					Cytoplasmic protein of unknown function, potentially phosphorylated by Cdc28p; YBR138C is not an essential gene	biological_process	molecular_function	cytoplasm
YCL057C-A	YCL057C-A	MOS1	hom	Verified	5.10822966510907	1.62595620745561e-07	yes	7	1.32697153248236e-07	8	NA	FT	MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial protein essential for proper inner membrane organization; conserved component of the mitochondrial inner membrane organizing system (MICOS, MINOS, or MitOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture; ortholog of human MINOS1	cristae formation	molecular_function	mitochondrion|mitochondrial crista junction|integral to mitochondrial inner membrane
YML097C	YML097C	VPS9	hom	Verified	4.96942223831685	3.35763473052034e-07	yes	8	8.85476721280368e-07	37	NA	FF|FT	PROTEIN LOCALIZATION|VACUOLAR TRANSPORT			A guanine nucleotide exchange factor involved in vesicle-mediated vacuolar protein transport; specifically stimulates the intrinsic guanine nucleotide exchange activity of Vps21p/Rab5: similar to mammalian ras inhibitors; binds ubiquitin	vacuole inheritance|protein targeting to vacuole	ubiquitin binding|guanyl-nucleotide exchange factor activity	cytosol
YGR134W	YGR134W	CAF130	hom	Verified	4.75977531977601	9.69042927789704e-07	yes	9	7.77402435505315e-07	5	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Part of the evolutionarily-conserved CCR4-NOT transcriptional regulatory complex involved in controlling mRNA initiation, elongation, and degradation	regulation of transcription from RNA polymerase II promoter|positive regulation of transcription elongation from RNA polymerase II promoter	molecular_function	CCR4-NOT core complex
YNL055C	YNL055C	POR1	hom	Verified	4.43426437616076	4.61935994565542e-06	yes	10	5.72443432049448e-05	19	NA	FT	ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS	MITOCHONDRION		Mitochondrial porin (voltage-dependent anion channel); outer membrane protein required for the maintenance of mitochondrial osmotic stability and mitochondrial membrane permeability; phosphorylated; protein abundance increases in response to DNA replication stress; POR1 has a paralog, POR2, that arose from the whole genome duplication	DNA transport|mitochondrion organization|apoptotic process|ion transport|cell redox homeostasis	voltage-gated anion channel activity	mitochondrial outer membrane|mitochondrion|integral to mitochondrial outer membrane
YOL013C	YOL013C	HRD1	hom	Verified	4.40677041166426	5.24616489339275e-06	yes	11	2.36789057072497e-07	10	NA	FT	CELL WALL ORG/BIOGENESIS|PROTEOLYSIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	UBIQUITIN LIGASE COMPLEX	Ubiquitin-protein ligase; required for endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins; genetically linked to the unfolded protein response (UPR); regulated through association with Hrd3p; contains an H2 ring finger; likely plays a general role in targeting proteins that persistently associate with and potentially obstruct the ER-localized translocon	fungal-type cell wall organization|ER-associated protein catabolic process	ubiquitin-protein ligase activity	Hrd1p ubiquitin ligase ERAD-M complex|integral to membrane|Hrd1p ubiquitin ligase ERAD-L complex|endoplasmic reticulum membrane
YJR103W	YJR103W	URA8	hom	Verified	4.38362586025303	5.83600818292878e-06	yes	12	4.4478995123687e-07	4	NA	FT	KETONE METABOLISM|LIPID METABOLISM|AMINO ACID METABOLISM|NUCLEOTIDE METABOLISM			Minor CTP synthase isozyme (see also URA7); catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis; capable of forming cytoplasmic filaments termed cytoophidium, especially during conditions of glucose depletion; URA8 has a paralog, URA7, that arose from the whole genome duplication	pyrimidine nucleobase biosynthetic process|CTP biosynthetic process|phospholipid biosynthetic process	CTP synthase activity	cytosol
YOR375C	YOR375C	GDH1	hom	Verified	4.23818889610336	1.12665074493743e-05	yes	13	1.14612355148976e-05	7	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS	NUCLEUS		NADP(+)-dependent glutamate dehydrogenase; synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh3p; expression regulated by nitrogen and carbon sources; GDH1 has a paralog, GDH3, that arose from the whole genome duplication	glutamate biosynthetic process|ammonia assimilation cycle	glutamate dehydrogenase (NADP+) activity	nucleus|cytoplasm
YOR291W	YOR291W	YPK9	hom	Verified	4.22508715496007	1.19424160676224e-05	yes	14	2.44686466523331e-06	5	NA	FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS			Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome	biological_process	molecular_function	fungal-type vacuole membrane|integral to membrane
YKL116C	YKL116C	PRR1	hom	Verified	4.07373810628974	2.31322524620845e-05	yes	15	1.46694699830087e-06	9	NA	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN PHOSPHORYLATION			Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor	negative regulation of transcription from RNA polymerase II promoter by pheromones|negative regulation of conjugation with cellular fusion|protein phosphorylation	protein kinase activity|receptor signaling protein serine/threonine kinase activity	cytoplasm
YCL022C_d	YCL022C	YCL022C	hom	Dubious	4.03963677793992	2.67670207629453e-05	yes	16	2.55060725969085e-06	3	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene KCC4/YCL024W	Unknown	Unknown	Unknown
YDR391C_p	YDR391C	YDR391C	hom	Uncharacterized	4.01142088446803	3.01772014866981e-05	yes	17	2.43209814876026e-05	12	NA	FT		NUCLEUS		Putative protein of unknown function, possibly involved in zinc homeostasis; Bdf1p-dependent transcription induced by salt stress; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus	biological_process	molecular_function	nucleus|cytoplasm
YDR392W	YDR392W	SPT3	hom	Verified	3.97741418250643	3.48343769429376e-05	yes	18	0.00118199150236347	108	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION	NUCLEUS	HISTONE ACETYLTRANSFERASE	Subunit of the SAGA and SAGA-like transcriptional regulatory complexes, interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes, also functions to inhibit transcription at some promoters	conjugation with cellular fusion|histone acetylation|pseudohyphal growth|ascospore formation|chromatin modification|invasive growth in response to glucose limitation|transcription from RNA polymerase II promoter	transcription cofactor activity	SLIK (SAGA-like) complex|SAGA complex
YFL052W_p	YFL052W	YFL052W	hom	Uncharacterized	3.95741722289041	3.78822649402565e-05	yes	19	8.43483630282295e-06	5	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Putative zinc cluster protein that contains a DNA binding domain; computational analysis suggests a role as a transcription factor; null mutant is sensitive to Calcofluor White, low osmolarity, and heat, suggesting a role for YFL052Wp in cell wall integrity	biological_process	DNA binding	cellular_component
YKL017C	YKL017C	HCS1	hom	Verified	3.81253158172006	6.87753233968899e-05	yes	20	2.63456141791587e-05	18	NA	FT		NUCLEUS|CHROMOSOME		Hexameric DNA polymerase alpha-associated DNA helicase A involved in lagging strand DNA synthesis; contains single-stranded DNA stimulated ATPase and dATPase activities; replication protein A stimulates helicase and ATPase activities	lagging strand elongation	ATP-dependent 5'-3' DNA helicase activity	DNA helicase A complex|alpha DNA polymerase:primase complex
YIL108W	YIL108W	YIL108W	hom	Verified	3.81058531332482	6.93190786026762e-05	yes	21	1.24398208213919e-05	4	NA	FT	PROTEOLYSIS			Putative metalloendopeptidase; forms cytoplasmic foci upon DNA replication stress	biological_process	molecular_function	cytoplasm
YFR007W	YFR007W	YFH7	hom	Verified	3.69728167642423	0.000108960248605582	yes	22	4.38792047932972e-05	44	NA					Putative kinase with similarity to the phosphoribulokinase/uridine kinase/bacterial pantothenate kinase (PRK/URK/PANK) subfamily of P-loop kinases	phosphorylation	ATPase activity|kinase activity	cellular_component
YOR154W_p	YOR154W	SLP1	hom	Uncharacterized	3.59565766401477	0.000161786542434018	yes	23	2.93073018670593e-05	11	NA					Glycosylated integral ER membrane protein of unknown function; forms an ER-membrane associated protein complex with Emp65p; member of the SUN-like family of proteins; genetic interactions suggest a role in folding of ER membrane proteins; required for nuclear envelope localization of Mps3p	protein folding in endoplasmic reticulum	molecular_function	cellular_component
YOL125W	YOL125W	TRM13	hom	Verified	3.56045758437731	0.000185104554745771	yes	24	1.28510947479544e-05	9	NA	FT	RNA PROCESSING	NUCLEUS		2'-O-methyltransferase responsible for modification of tRNA at position 4; C-terminal domain has similarity to Rossmann-fold (RFM) superfamily of RNA methyltransferases	tRNA methylation	tRNA methyltransferase activity	nucleus|cytoplasm
YKR036C	YKR036C	CAF4	hom	Verified	3.53180177062232	0.000206369314615098	yes	25	0.000159333927956771	19	NA	FT	TRANSCRIPTION FROM RNA POL II|MITOCHONDRION ORGANIZATION|PEROXISOME ORGANIZATION	NUCLEUS|MITOCHONDRION		WD40 repeat-containing protein associated with the CCR4-NOT complex; interacts in a Ccr4p-dependent manner with Ssn2p; also interacts with Fis1p, Mdv1p and Dnm1p and plays a role in mitochondrial fission; CAF4 has a paralog, MDV1, that arose from the whole genome duplication	peroxisome fission|mitochondrial fission|regulation of transcription from RNA polymerase II promoter	molecular_function	mitochondrion|CCR4-NOT complex
YIR018C-A_p	YIR018C-A	YIR018C-A	hom	Uncharacterized	3.51904363010427	0.000216552737445516	yes	26	0.000135878859363584	20	NA					Putative protein of unknown function; identified by expression profiling and mass spectrometry	biological_process	molecular_function	cellular_component
YER081W	YER081W	SER3	hom	Verified	3.51398639566618	0.000220717710141505	yes	27	0.000241126593176069	10	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS			3-phosphoglycerate dehydrogenase; catalyzes the first step in serine and glycine biosynthesis; SER3 has a paralog, SER33, that arose from the whole genome duplication	serine family amino acid biosynthetic process	phosphoglycerate dehydrogenase activity	cytoplasm
YHL012W_p	YHL012W	YHL012W	hom	Uncharacterized	3.49767359567841	0.000234667577883038	yes	28	4.59807205653061e-05	6	NA					Putative UTP glucose-1-phosphate uridylyltransferase; YHL012W has a paralog, UGP1, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YLR082C	YLR082C	SRL2	hom	Verified	3.48261441243166	0.000248271495305729	yes	29	0.000261935643290925	10	NA	FT		NUCLEUS		Protein of unknown function; overexpression suppresses the lethality caused by a rad53 null mutation	nucleobase-containing compound metabolic process	molecular_function	nucleus|cytoplasm
YNL035C	YNL035C	YNL035C	hom	Verified	3.47859961494182	0.000252020530503563	yes	30	0.000101344637256302	17	NA	FT		NUCLEUS		Protein of unknown function; contains WD-40 domains; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YNL035C is not an essential gene; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	nucleus
YMR137C	YMR137C	PSO2	hom	Verified	3.46195972446055	0.000268128698974165	yes	31	4.17075852810451e-05	10	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		Nuclease required for DNA single- and double-strand break repair; acts at a post-incision step in repair of breaks that result from interstrand cross-links produced by a variety of mono- and bi-functional psoralen derivatives; induced by UV-irradiation; forms nuclear foci upon DNA replication stress	DNA repair|double-strand break repair	damaged DNA binding|5'-3' exonuclease activity	nucleus
YMR023C	YMR023C	MSS1	hom	Verified	3.41566379425531	0.000318133754496014	yes	32	5.28625114690982e-05	11	NA	FT	RNA PROCESSING|SIGNALING|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial protein, forms a heterodimer complex with Mto1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; similar to human GTPBP3	mitochondrial tRNA wobble uridine modification|Unknown	GTP binding	mitochondrion|mitochondrial inner membrane
YLR119W	YLR119W	SRN2	hom	Verified	3.38112794113	0.000360944609150207	yes	33	0.000542086707900428	54	NA	FT	PROTEIN LOCALIZATION|PROTEOLYSIS|VACUOLAR TRANSPORT			Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; suppressor of rna1-1 mutation; may be involved in RNA export from nucleus	protein targeting to membrane|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|protein targeting to vacuole	protein binding	endosome|ESCRT I complex
YJL118W	YJL118W	YJL118W	hom	Verified	3.37422122365246	0.000370124259607041	yes	34	0.000126646332944752	5	NA					Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; YJL18W is a non-essential gene; deletion enhances the toxicity of heterologously expressed human alpha-synuclein	biological_process	molecular_function	ribosome
YOR371C	YOR371C	GPB1	hom	Verified	3.33482641195829	0.000426763311047451	yes	35	0.000262371839610135	20	NA	FT	SIGNALING|PROTEOLYSIS	PLASMA MEMBRANE		Multistep regulator of cAMP-PKA signaling; inhibits PKA downstream of Gpa2p and Cyr1p, thereby increasing cAMP dependency; promotes ubiquitin-dependent proteolysis of Ira2p; regulated by G-alpha protein Gpa2p; GPB1 has a paralog, GPB2, that arose from the whole genome duplication	positive regulation of Ras protein signal transduction|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|negative regulation of phosphorylation|signal transduction|glucose mediated signaling pathway|pseudohyphal growth|invasive growth in response to glucose limitation|negative regulation of Ras protein signal transduction|protein polyubiquitination	cAMP-dependent protein kinase inhibitor activity|signal transducer activity|GTPase activating protein binding	plasma membrane|cytoplasm
YPL263C	YPL263C	KEL3	hom	Verified	3.30171683099321	0.00048047514581256	yes	36	0.000104712145134457	18	NA					Cytoplasmic protein of unknown function	biological_process	molecular_function	cytoplasm
YGL134W	YGL134W	PCL10	hom	Verified	3.28501816265179	0.000509878988887486	yes	37	7.76798037482413e-05	10	NA	FT	CELL CYCLE|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION|GEN. OF PRECURSOR METABOLITES AND ENERGY			Pho85p cyclin; recruits, activates, and targets Pho85p cyclin-dependent protein kinase to its substrate	negative regulation of glycogen biosynthetic process|regulation of cyclin-dependent protein kinase activity	cyclin-dependent protein kinase regulator activity	cyclin-dependent protein kinase holoenzyme complex
YGL237C	YGL237C	HAP2	hom	Verified	3.23579175891669	0.000606529226916491	yes	38	0.000299632713339386	26	NA	FT	TRANSCRIPTION FROM RNA POL II|OXIDATION-REDUCTION PROCESS|RESPONSE TO NUTRIENT LEVELS|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS		Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding	carbon catabolite activation of transcription from RNA polymerase II promoter|regulation of cellular respiration	RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	CCAAT-binding factor complex|nucleus
YER074W	YER074W	RPS24A	hom	Verified	3.18608172827181	0.000721069257726108	yes	39	0.000957135890769311	46	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION	NUCLEUS|MITOCHONDRION	RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S24, no bacterial homolog; RPS24A has a paralog, RPS24B, that arose from the whole genome duplication	cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome	cytosolic small ribosomal subunit|mitochondrion
YLR023C	YLR023C	IZH3	hom	Verified	3.15409311844365	0.000804988529893384	yes	40	0.000112404993398949	15	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family, expression induced by zinc deficiency; deletion reduces sensitivity to elevated zinc and shortens lag phase, overexpression reduces Zap1p activity	cellular zinc ion homeostasis	metal ion binding	integral to membrane|endoplasmic reticulum|membrane
YAL004W_d	YAL004W	YAL004W	hom	Dubious	3.15099128936148	0.000813586714764108	yes	41	0.00186986049964039	37	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene SSA1/YAL005C	Unknown	Unknown	Unknown
YGR089W	YGR089W	NNF2	hom	Verified	3.14989932140343	0.000816633679457369	yes	42	0.000611702649714063	44	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein that exhibits physical and genetic interactions with Rpb8p, which is a subunit of RNA polymerases I, II, and III; computational analysis of large-scale protein-protein interaction data suggests a role in chromosome segregation	biological_process	molecular_function	integral to membrane
YHR185C	YHR185C	PFS1	hom	Verified	3.10774411634013	0.0009426060882563	yes	43	0.00132851317540378	25	NA	FT	CELL WALL ORG/BIOGENESIS	NUCLEUS|CYTOSKELETON		Sporulation protein required for prospore membrane formation at selected spindle poles, ensures functionality of all four spindle pole bodies during meiosis II; not required for meiotic recombination or meiotic chromosome segregation	ascospore wall assembly	molecular_function	cellular_component
YOR112W	YOR112W	CEX1	hom	Verified	3.09060451200056	0.000998747469932537	yes	44	0.00101171273484673	34	NA	FT	RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS		Cytoplasmic component of the nuclear aminoacylation-dependent tRNA export pathway; interacts with nuclear pore component Nup116p; copurifies with tRNA export receptors Los1p and Msn5p, as well as eIF-1a and the RAN GTPase Gsp1p	tRNA export from nucleus	tRNA binding	nuclear pore|cytoplasm
YIR020C_p	YIR020C	YIR020C	hom	Uncharacterized	3.08374841764671	0.0010220518687837	no	45	0.000260769713417596	25	NA					Protein of unknown function; mRNA identified as translated by ribosome profiling data	biological_process	molecular_function	cellular_component
YGR271C-A	YGR271C-A	EFG1	hom	Verified	3.0768764058905	0.0010459100709949	no	46	0.00268701424435087	64	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Essential protein required for maturation of 18S rRNA; null mutant is sensitive to hydroxyurea and is delayed in recovering from alpha-factor arrest; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus	G1 phase of mitotic cell cycle|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	molecular_function	nucleolus
YGR133W	YGR133W	PEX4	hom	Verified	3.06250296437452	0.00109747150723746	no	47	0.000389335908845421	24	NA	FT	PROTEIN LOCALIZATION|SIGNALING|PEROXISOME ORGANIZATION			Peroxisomal ubiquitin conjugating enzyme required for peroxisomal matrix protein import and peroxisome biogenesis	peroxisome organization|protein import into peroxisome matrix, receptor recycling|protein autoubiquitination|protein monoubiquitination|protein polyubiquitination	ubiquitin-protein ligase activity	peroxisome
YOL080C	YOL080C	REX4	hom	Verified	3.0352480008087	0.00120168986412685	no	48	0.000583955859539811	10	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Putative RNA exonuclease possibly involved in pre-rRNA processing and ribosome assembly	ribosomal large subunit assembly|rRNA processing	3'-5' exonuclease activity	nucleolus|nucleus
YIL135C	YIL135C	VHS2	hom	Verified	2.9896662686736	0.00139641201021345	no	49	0.00038189558965305	26	NA	FT	CELL CYCLE			Cytoplasmic protein of unknown function; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; similar to Mlf3p	G1/S transition of mitotic cell cycle	molecular_function	cytoplasm
YPL078C	YPL078C	ATP4	hom	Verified	2.94087317267705	0.00163644254291435	no	50	0.00204226304091396	53	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS	MITOCHONDRION		Subunit b of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; contributes to the oligomerization of the complex; phosphorylated	protein complex oligomerization|ATP synthesis coupled proton transport	proton-transporting ATPase activity, rotational mechanism	mitochondrion|mitochondrial proton-transporting ATP synthase, stator stalk|integral to membrane
YDL210W	YDL210W	UGA4	hom	Verified	2.92471245700294	0.00172387319679224	no	51	0.000419768645565214	10	NA					Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane	gamma-aminobutyric acid transport|putrescine transport|transmembrane transport	putrescine transmembrane transporter activity|gamma-aminobutyric acid:hydrogen symporter activity	fungal-type vacuole membrane|integral to membrane
YJR094W-A	YJR094W-A	RPL43B	hom	Verified	2.91162861605435	0.00179774924510866	no	52	0.000814414387159821	24	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L43B; homologous to mammalian ribosomal protein L37A, no bacterial homolog; RPL43B has a paralog, RPL43A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YER002W	YER002W	NOP16	hom	Verified	2.90092916120581	0.00186028988392977	no	53	0.00316656012126878	48	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis	ribosomal large subunit biogenesis	molecular_function	nucleolus|nucleus|preribosome, large subunit precursor
YHL033C	YHL033C	RPL8A	hom	Verified	2.89220705412049	0.00191272872803975	no	54	0.00356515573813422	61	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L8A; mutation results in decreased amounts of free 60S subunits; homologous to mammalian ribosomal protein L7A, no bacterial homolog; RPL8A has a paralog, RPL8B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YIL010W	YIL010W	DOT5	hom	Verified	2.88091569817443	0.00198260840618469	no	55	0.000701319421709568	12	NA	FT	OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS	NUCLEUS|CHROMOSOME		Nuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase during post-diauxic growth	cellular response to oxidative stress|cell redox homeostasis	thioredoxin peroxidase activity	nucleus
YLR192C	YLR192C	HCR1	hom	Verified	2.87087419657209	0.00204669198069435	no	56	0.00671175327784926	99	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION			Dual function protein involved in translation initiation as a substoichiometric component (eIF3j) of translation initiation factor 3 (eIF3) and required for processing of 20S pre-rRNA; binds to eIF3 subunits Rpg1p and Prt1p and 18S rRNA	cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	translation initiation factor activity	eukaryotic translation initiation factor 3 complex
YGL216W	YGL216W	KIP3	hom	Verified	2.86542088336234	0.00208227661402769	no	57	0.000782260612812586	20	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CYTOSKELETON ORGANIZATION	NUCLEUS|CYTOSKELETON		Kinesin-related motor protein involved in mitotic spindle positioning	nuclear migration along microtubule|mitotic spindle disassembly|establishment of mitotic spindle orientation|plus-end specific microtubule depolymerization|mitotic spindle organization in nucleus	plus-end-directed microtubule motor activity|tubulin-dependent ATPase activity	kinesin complex|cytoplasmic microtubule|nuclear microtubule
YJR053W	YJR053W	BFA1	hom	Verified	2.86174223697486	0.00210659702571086	no	58	0.000660085527788533	25	NA	FT	CELL CYCLE|CELL DIVISION	CYTOSKELETON		Component of the GTPase-activating Bfa1p-Bub2p complex involved in multiple cell cycle checkpoint pathways that control exit from mitosis	regulation of exit from mitosis|mitotic cell cycle spindle orientation checkpoint	GTPase activator activity	spindle pole body
YMR285C	YMR285C	NGL2	hom	Verified	2.83904682973993	0.00226242578819716	no	59	0.000864319988153189	33	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Protein involved in 5.8S rRNA processing; Ccr4p-like RNase required for correct 3'-end formation of 5.8S rRNA at site E; similar to Ngl1p; NGL2 has a paralog, NGL3, that arose from the whole genome duplication	rRNA processing	endoribonuclease activity	intracellular
YMR320W_d	YMR320W	YMR320W	hom	Dubious	2.83583528881653	0.00228530056271419	no	60	0.00133274483324202	65	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YML066C	YML066C	SMA2	hom	Verified	2.81460733145786	0.00244184331686112	no	61	0.00121047783291657	45	NA	FT	MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS	ENDOPLASMIC RETICULUM		Meiosis-specific prospore membrane protein; required to produce bending force necessary for proper assembly of the prospore membrane during sporulation	ascospore wall assembly|spore membrane bending pathway	molecular_function	integral to membrane|prospore membrane|cytoplasm
YLR107W	YLR107W	REX3	hom	Verified	2.80788785985304	0.00249337942710431	no	62	0.00121883380347711	22	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		RNA exonuclease; required for maturation of the RNA component of RNase MRP; functions redundantly with Rnh70p and Rex2p in processing of U5 snRNA and RNase P RNA; member of RNase D family of exonucleases	U5 snRNA 3'-end processing|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|ncRNA 3'-end processing	3'-5'-exoribonuclease activity|3'-5' exonuclease activity	nucleus|cytoplasm
YOR242C	YOR242C	SSP2	hom	Verified	2.7883367158309	0.00264897235001352	no	63	0.00110615208186592	34	NA	FT	CELL WALL ORG/BIOGENESIS			Sporulation specific protein that localizes to the spore wall; required for sporulation at a point after meiosis II and during spore wall formation; SSP2 expression is induced midway in meiosis	ascospore wall assembly|ascospore formation	molecular_function	ascospore wall
YGL110C	YGL110C	CUE3	hom	Verified	2.76989607589861	0.00280370904923848	no	64	0.000908433159947041	24	NA					Protein of unknown function; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination	biological_process	ubiquitin binding	cytoplasm
YOR316C-A_p	YOR316C-A	YOR316C-A	hom	Uncharacterized	2.75168666068015	0.00296446100373753	no	65	0.00138479459084885	37	NA					Putative protein of unknown function; identified by fungal homology and RT-PCR	biological_process	molecular_function	cellular_component
YMR299C	YMR299C	DYN3	hom	Verified	2.72633482235482	0.003202099877686	no	66	0.00289451891307617	67	NA	FT		CYTOSKELETON		Dynein light intermediate chain (LIC); localizes with dynein, null mutant is defective in nuclear migration	nuclear migration along microtubule	motor activity	cytoplasmic dynein complex|cytoplasmic microtubule
YGL256W	YGL256W	ADH4	hom	Verified	2.72248354704478	0.00323966298404658	no	67	0.00165140609858986	45	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Alcohol dehydrogenase isoenzyme type IV, dimeric enzyme demonstrated to be zinc-dependent despite sequence similarity to iron-activated alcohol dehydrogenases; transcription is induced in response to zinc deficiency	fermentation|amino acid catabolic process to alcohol via Ehrlich pathway	alcohol dehydrogenase (NAD) activity	mitochondrion
YBR225W_p	YBR225W	YBR225W	hom	Uncharacterized	2.70644193949007	0.00340042367265158	no	68	0.00206664676621368	32	NA					Putative protein of unknown function; non-essential gene identified in a screen for mutants affected in mannosylphophorylation of cell wall components	biological_process	molecular_function	cellular_component
YNR070W_p	YNR070W	PDR18	hom	Uncharacterized	2.70349726602171	0.00343070062233395	no	69	0.00222194125560713	41	NA	FT	NUCLEOTIDE METABOLISM	MITOCHONDRION		Putative transporter of the ATP-binding cassette (ABC) family, implicated in pleiotropic drug resistance; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	transport	ATPase activity, coupled to transmembrane movement of substances	mitochondrion|integral to membrane|membrane
YPL213W	YPL213W	LEA1	hom	Verified	2.69750069069138	0.00349310699123898	no	70	0.00305533824138119	79	NA	FT	RNA PROCESSING	NUCLEUS		Component of U2 snRNP; disruption causes reduced U2 snRNP levels; physically interacts with Msl1p; putative homolog of human U2A' snRNP protein	mRNA splicing, via spliceosome	molecular_function	U2 snRNP|U2-type prespliceosome|cytoplasm
YDR384C	YDR384C	ATO3	hom	Verified	2.6934451752599	0.00353588874351407	no	71	0.00229967594976517	36	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION|PLASMA MEMBRANE		Plasma membrane protein, regulation pattern suggests a possible role in export of ammonia from the cell; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family of putative transporters	ammonium transport|nitrogen utilization|transmembrane transport	ammonium transmembrane transporter activity	mitochondrion|integral to membrane|plasma membrane
YMR095C	YMR095C	SNO1	hom	Verified	2.67411806411826	0.00374630341763199	no	72	0.00129715569072005	27	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Protein of unconfirmed function, involved in pyridoxine metabolism; expression is induced during stationary phase; forms a putative glutamine amidotransferase complex with Snz1p, with Sno1p serving as the glutaminase	pyridoxine metabolic process|thiamine biosynthetic process|anti-apoptosis	molecular_function	cytoplasm
YOR062C_p	YOR062C	YOR062C	hom	Uncharacterized	2.65007687876072	0.00402367283751414	no	73	0.00229340547970073	36	NA	FT		NUCLEUS		Protein of unknown function; similar to YKR075Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS	biological_process	molecular_function	nucleus|cytoplasm
YML103C	YML103C	NUP188	hom	Verified	2.64377593826042	0.00409934541811429	no	74	0.00372778327640441	51	NA	FT	PROTEIN LOCALIZATION|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188	nuclear pore organization|protein import into nucleus|mRNA export from nucleus in response to heat stress	structural constituent of nuclear pore	integral to membrane|nuclear pore|nuclear pore inner ring
YGL096W	YGL096W	TOS8	hom	Verified	2.63922055502661	0.00415484497754965	no	75	0.00195034975125142	28	NA	FT		NUCLEUS|CHROMOSOME		Homeodomain-containing protein and putative transcription factor; found associated with chromatin; target of SBF transcription factor; induced during meiosis and under cell-damaging conditions; TOS8 has a paralog, CUP9, that arose from the whole genome duplication	biological_process	chromatin binding|sequence-specific DNA binding	nuclear chromatin
YLR189C	YLR189C	ATG26	hom	Verified	2.63495512687207	0.00420742034354398	no	76	0.00200841151098847	33	NA	FT	PROTEIN LOCALIZATION|LIPID METABOLISM|MEMBRANE ORGANIZATION|CARBOHYDRATE METABOLISM			UDP-glucose:sterol glucosyltransferase, conserved enzyme involved in synthesis of sterol glucoside membrane lipids; in contrast to ATG26 from P. pastoris, S. cerevisiae ATG26 is not involved in autophagy	sterol metabolic process|ascospore-type prospore membrane assembly	sterol 3-beta-glucosyltransferase activity	cytoplasm
YFR039C_p	YFR039C	YFR039C	hom	Uncharacterized	2.62819013261395	0.00429202609127449	no	77	0.00203209398697768	26	NA					Putative protein of unknown function; may be involved in response to high salt and changes in carbon source; deletion mutant has decreased spore survival in Drosophila feces	biological_process	molecular_function	cellular_component
YJL055W_p	YJL055W	YJL055W	hom	Uncharacterized	2.62448213061232	0.00433904230776259	no	78	0.00458867982169389	68	NA	FT		NUCLEUS		Putative protein of unknown function, proposed to be involved in the metabolism of purine and pyrimidine base analogues; deletion mutants are sensitive to HAP and AHA; overexpression confers resistance to 5-FOA and 5-FU	response to chemical stimulus|response to purine-containing compound	molecular_function	nucleus|cytoplasm
YBL062W_d	YBL062W	YBL062W	hom	Dubious	2.6212723256988	0.0043801126784409	no	79	0.00754338441330008	98	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDR486C	YDR486C	VPS60	hom	Verified	2.61911732526699	0.00440788106898306	no	80	0.00602864988105701	74	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT			Cytoplasmic and vacuolar membrane protein involved in late endosome to vacuole transport; required for normal filament maturation during pseudohyphal growth; may function in targeting cargo proteins for degradation; interacts with Vta1p	late endosome to vacuole transport via multivesicular body sorting pathway|filamentous growth	molecular_function	fungal-type vacuole membrane|cytoplasm
YDL032W_d	YDL032W	YDL032W	hom	Dubious	2.60820687295378	0.00455089644387978	no	81	0.00809064446941748	114	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene SLM3/YDL033C; YDL032W is not an essential gene	Unknown	Unknown	Unknown
YML058W	YML058W	SML1	hom	Verified	2.59749696141803	0.00469529755453631	no	82	0.00113694499734579	26	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|MITOCHONDRION ORGANIZATION	NUCLEUS		Ribonucleotide reductase inhibitor involved in regulating dNTP production; regulated by Mec1p and Rad53p during DNA damage and S phase	mitochondrion organization|response to DNA damage stimulus	enzyme inhibitor activity	nucleus|cytoplasm
YLR357W	YLR357W	RSC2	hom	Verified	2.59324491898823	0.0047537518600923	no	83	0.00499709599920921	71	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION	NUCLEUS	RSC COMPLEX	Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; involved in telomere maintenance	ATP-dependent chromatin remodeling|chromosome segregation|nucleosome disassembly|plasmid maintenance|sister chromatid cohesion|double-strand break repair via nonhomologous end joining|transcription elongation from RNA polymerase II promoter|double-strand break repair via homologous recombination	DNA translocase activity	RSC complex
YMR230W-A_p	YMR230W-A	YMR230W-A	hom	Uncharacterized	2.58942039640084	0.00480688237347275	no	84	0.00468769251696739	71	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YCL008C	YCL008C	STP22	hom	Verified	2.58626328443478	0.00485113939737679	no	85	0.0110452818002007	169	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEOLYSIS|VACUOLAR TRANSPORT	PLASMA MEMBRANE		Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; homologous to the mouse and human Tsg101 tumor susceptibility gene; mutants exhibit a Class E Vps phenotype	protein targeting to membrane|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|late endosome to vacuole transport|protein targeting to vacuole	ubiquitin binding	endosome|ESCRT I complex|internal side of plasma membrane
YKR044W	YKR044W	UIP5	hom	Verified	2.58334673792232	0.00489234649449087	no	86	0.00342264444557592	38	NA	FT		ENDOMEMBRANE SYSTEM|NUCLEUS		Protein of unknown function that interacts with Ulp1p, a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates	biological_process	molecular_function	nuclear envelope
YKL214C	YKL214C	YRA2	hom	Verified	2.56589446397772	0.00514550669939436	no	87	0.00218678601339434	52	NA	FT	RNA LOCALIZATION	NUCLEUS		Member of the REF (RNA and export factor binding proteins) family; when overexpressed, can substitute for the function of Yra1p in export of poly(A)+ mRNA from the nucleus	poly(A)+ mRNA export from nucleus	RNA binding	nucleus
YGR234W	YGR234W	YHB1	hom	Verified	2.56046770139264	0.00522656897518932	no	88	0.00206723781752771	41	NA	FT	OXIDATION-REDUCTION PROCESS	MITOCHONDRION		Nitric oxide oxidoreductase; flavohemoglobin involved in nitric oxide detoxification; plays a role in the oxidative and nitrosative stress responses; protein increases in abundance and relocalizes from nucleus to cytoplasmic foci upon DNA replication stress	response to stress	nitric oxide reductase activity	cytosol|mitochondrion|mitochondrial matrix|cytoplasm
YFL004W	YFL004W	VTC2	hom	Verified	2.56009562796835	0.0052321682193063	no	89	0.00409794491447045	38	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT	ENDOPLASMIC RETICULUM		Subunit of the vacuolar transporter chaperone (VTC) complex involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion	polyphosphate metabolic process|vacuolar transport|microautophagy|protein localization|vacuole fusion, non-autophagic	molecular_function	fungal-type vacuole membrane|integral to membrane|endoplasmic reticulum|vacuolar transporter chaperone complex
YHR114W	YHR114W	BZZ1	hom	Verified	2.55942033031598	0.00524234424647576	no	90	0.00249925881316237	47	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		SH3 domain protein implicated in the regulation of actin polymerization, able to recruit actin polymerization machinery through its SH3 domains, colocalizes with cortical actin patches and Las17p, interacts with type I myosins	response to salt stress|actin filament organization|endocytosis	molecular_function	mating projection tip|cytoplasm|actin cortical patch
YNL125C	YNL125C	ESBP6	hom	Verified	2.54865934653869	0.00540689361302219	no	91	0.00448991093785251	80	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION		Protein with similarity to monocarboxylate permeases, appears not to be involved in transport of monocarboxylates such as lactate, pyruvate or acetate across the plasma membrane	transport	monocarboxylic acid transmembrane transporter activity|transporter activity	mitochondrion|integral to membrane|endoplasmic reticulum|membrane
YHL006C	YHL006C	SHU1	hom	Verified	2.54067078669285	0.00553200214959513	no	92	0.0010776176036527	39	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function	recombinational repair|maintenance of rDNA	molecular_function	nucleolus|Shu complex
YBR207W	YBR207W	FTH1	hom	Verified	2.53482316255255	0.00562520516656254	no	93	0.000956835503289098	30	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS			Putative high affinity iron transporter; involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis; protein abundance increases in response to DNA replication stress	endocytosis|high-affinity iron ion transport	iron ion transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane
YHR137W	YHR137W	ARO9	hom	Verified	2.53046426256399	0.00569558443054169	no	94	0.00394668371073342	64	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Aromatic aminotransferase II, catalyzes the first step of tryptophan, phenylalanine, and tyrosine catabolism	aromatic amino acid family metabolic process	aromatic-amino-acid:2-oxoglutarate aminotransferase activity	nucleus|cytoplasm
YDL138W	YDL138W	RGT2	hom	Verified	2.50649460853144	0.00609674586320363	no	95	0.00207369955727462	26	NA	FT	SIGNALING	PLASMA MEMBRANE		Plasma membrane high glucose sensor that regulates glucose transport; contains 12 predicted transmembrane segments and a long C-terminal tail required for induction of hexose transporters; RGT2 has a paralog, SNF3, that arose from the whole genome duplication	glucose transport|signal transduction|detection of glucose	glucose transmembrane transporter activity|receptor activity|glucose binding	integral to membrane|plasma membrane
YPL021W	YPL021W	ECM23	hom	Verified	2.50145783005133	0.0061841585605058	no	96	0.00307136723112942	53	NA	FT	CELL WALL ORG/BIOGENESIS			Non-essential protein of unconfirmed function; affects pre-rRNA processing, may act as a negative regulator of the transcription of genes involved in pseudohyphal growth; homologous to Srd1p	pseudohyphal growth	sequence-specific DNA binding	cellular_component
YJR094C	YJR094C	IME1	hom	Verified	2.49221893608813	0.00634738796212179	no	97	0.00187850433957599	43	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE	NUCLEUS		Master regulator of meiosis that is active only during meiotic events, activates transcription of early meiotic genes through interaction with Ume6p, degraded by the 26S proteasome following phosphorylation by Ime2p	pseudohyphal growth|regulation of transcription from RNA polymerase II promoter|regulation of meiosis	protein binding transcription factor activity	nucleus
YLR064W	YLR064W	PER33	hom	Verified	2.48505521067316	0.0064765671849049	no	98	0.00507942964264908	64	NA	FT	PROTEIN LOCALIZATION|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM	NUCLEAR PORE	Protein that localizes to the endoplasmic reticulum; also associates with the nuclear pore complex; deletion extends chronological lifespan; highly conserved across species, orthologous to human TMEM33 and paralogous to Pom33p; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	integral to membrane|endoplasmic reticulum|nuclear pore
YPR198W	YPR198W	SGE1	hom	Verified	2.48130363025683	0.0065451407391536	no	99	0.0208632458337908	210	NA	FF|FT		PLASMA MEMBRANE		Plasma membrane multidrug transporter of the major facilitator superfamily, acts as an extrusion permease; partial multicopy suppressor of gal11 mutations	response to drug|drug transport	drug transmembrane transporter activity	integral to membrane|integral to plasma membrane
YPR126C_d	YPR126C	YPR126C	hom	Dubious	2.48081450183666	0.00655412846225734	no	100	0.00691493032051304	70	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YIR024C	YIR024C	YIR024C	hom	Verified	2.47777520716394	0.00661022043488799	no	101	0.00910834033793279	66	NA	FT		MITOCHONDRION		Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; interacts with Arh1p, a mitochondrial oxidoreductase; deletion mutant has a respiratory growth defect	biological_process	molecular_function	mitochondrion
YDR340W_d	YDR340W	YDR340W	hom	Dubious	2.47358192104943	0.00668830661025507	no	102	0.00339412009698313	39	NA					Putative protein of unknown function	Unknown	Unknown	Unknown
YGL170C	YGL170C	SPO74	hom	Verified	2.45869506749486	0.00697215000134101	no	103	0.00771955811367922	84	NA	FT		NUCLEUS|CYTOSKELETON		Component of the meiotic outer plaque of the spindle pole body, involved in modifying the meiotic outer plaque that is required prior to prospore membrane formation	ascospore formation	structural molecule activity	spindle pole body
YPR115W	YPR115W	RGC1	hom	Verified	2.45583912855477	0.00702780313171276	no	104	0.00813993514314859	81	NA	FT	CELL CYCLE			Pleckstrin homology domain containing protein; proposed to function as a glycerol channel activator; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; RGC1 has a paralog, ASK10, that arose from the whole genome duplication	positive regulation of glycerol transport	molecular_function	cytoplasm
YDR534C	YDR534C	FIT1	hom	Verified	2.4543025598052	0.00705790787251959	no	105	0.00248687195339794	33	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall	siderophore transport	molecular_function	fungal-type cell wall
YDL076C	YDL076C	RXT3	hom	Verified	2.44101092457699	0.00732310584901582	no	106	0.0104038733223338	101	NA	FT	CHROMATIN ORGANIZATION	NUCLEUS|CHROMOSOME		Subunit of the RPD3L complex; involved in histone deacetylation; protein abundance increases in response to DNA replication stress	negative regulation of transcription from RNA polymerase I promoter	molecular_function	Rpd3L-Expanded complex|nucleus|Rpd3L complex
YHL040C	YHL040C	ARN1	hom	Verified	2.43042532335838	0.00754055675133251	no	107	0.00434814256022937	31	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		ARN family transporter for siderophore-iron chelates; responsible for uptake of iron bound to ferrirubin, ferrirhodin, and related siderophores; protein increases in abundance and relocalizes to the vacuole upon DNA replication stress	siderophore transport	siderophore transmembrane transporter activity	endosome|integral to membrane|plasma membrane|cytoplasmic membrane-bounded vesicle
YGR149W_p	YGR149W	YGR149W	hom	Uncharacterized	2.42400373875278	0.00767522372523584	no	108	0.0037010133336601	40	NA					Putative protein of unknown function; predicted to be an integal membrane protein	biological_process	molecular_function	integral to membrane
YBR189W	YBR189W	RPS9B	hom	Verified	2.42068824618148	0.00774557811094692	no	109	0.0101921939122349	87	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION	NUCLEUS	RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S9 and bacterial S4; RPS9B has a paralog, RPS9A, that arose from the whole genome duplication	positive regulation of translational fidelity|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome	small-subunit processome|cytosolic small ribosomal subunit|90S preribosome
YIL097W	YIL097W	FYV10	hom	Verified	2.41722029471532	0.00781977434238457	no	110	0.00884525144277606	113	NA	FT	KETONE METABOLISM|CARBOHYDRATE METABOLISM|PROTEOLYSIS	NUCLEUS		Subunit of GID complex; involved in proteasome-dependent catabolite inactivation of gluconeogenic enzymes FBPase, PEPCK, and c-MDH; forms dimer with Rmd5p that is then recruited to GID Complex by Gid8p; contains a degenerate RING finger motif needed for GID complex ubiquitin ligase activity in vivo, as well as CTLH and CRA domains; plays role in anti-apoptosis; required for survival upon exposure to K1 killer toxin	negative regulation of gluconeogenesis|proteasomal ubiquitin-dependent protein catabolic process|anti-apoptosis	ubiquitin-protein ligase activity	nucleus|GID complex|cytoplasm
YKL106C-A_p	YKL106C-A	YKL106C-A	hom	Uncharacterized	2.41058026076038	0.007963583253896	no	111	0.00255970190512654	25	NA					Putative protein of unknown function; identified by homology to uncharacterized proteins in other fungi	biological_process	molecular_function	cellular_component
YMR230W	YMR230W	RPS10B	hom	Verified	2.40503276684419	0.00808550788460165	no	112	0.0100729199910173	86	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10B has a paralog, RPS10A, that arose from the whole genome duplication	cytoplasmic translation|rRNA export from nucleus	structural constituent of ribosome	cytosolic small ribosomal subunit
YDL119C_p	YDL119C	YDL119C	hom	Uncharacterized	2.38599267588103	0.0085165451404281	no	113	0.0118835621381624	164	NA	FF|FT	ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Putative mitochondrial transport protein; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in purified mitochondria	transport	transporter activity	mitochondrion|integral to membrane|mitochondrial inner membrane
YHR003C	YHR003C	YHR003C	hom	Verified	2.37904924316955	0.00867867852494434	no	114	0.0021234208292987	27	NA	FT		MITOCHONDRION		Protein of unknown function, localized to the mitochondrial outer membrane	biological_process	molecular_function	mitochondrial outer membrane|mitochondrion
YDL236W	YDL236W	PHO13	hom	Verified	2.37700147970956	0.00872700905492828	no	115	0.0114621948026249	69	NA	FT		NUCLEUS		Alkaline phosphatase specific for p-nitrophenyl phosphate; also has protein phosphatase activity	protein dephosphorylation	4-nitrophenylphosphatase activity|phosphoprotein phosphatase activity|alkaline phosphatase activity	nucleus|cytoplasm
YNL130C	YNL130C	CPT1	hom	Verified	2.37671935194665	0.0087336861885197	no	116	0.00472205525715785	59	NA	FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION|GOLGI APPARATUS		Cholinephosphotransferase; required for phosphatidylcholine biosynthesis and for inositol-dependent regulation of EPT1 transcription; CPT1 has a paralog, EPT1, that arose from the whole genome duplication	CDP-choline pathway	diacylglycerol cholinephosphotransferase activity	mitochondrial outer membrane|integral to membrane|Golgi apparatus
YJR119C	YJR119C	JHD2	hom	Verified	2.35368962714302	0.00929406213523396	no	117	0.00547864943981746	53	NA	FT	CHROMATIN ORGANIZATION|OXIDATION-REDUCTION PROCESS	NUCLEUS		JmjC domain family histone demethylase specific for H3-K4 (histone H3 Lys4); removes methyl groups specifically added by Set1p methyltransferase; protein levels regulated by Not4p (E3 ubiquitin ligase) polyubiquitin-mediated degradation	histone demethylation	histone demethylase activity (H3-K4 specific)	nucleus|cytoplasm
YLL033W	YLL033W	IRC19	hom	Verified	2.35090112147096	0.00936400490280241	no	118	0.006336616401406	64	NA					Putative protein of unknown function; YLL033W is not an essential gene but mutant is defective in spore formation; null mutant displays increased levels of spontaneous Rad52p foci	mitotic recombination|ascospore formation	molecular_function	cellular_component
YIR021W	YIR021W	MRS1	hom	Verified	2.35055698373505	0.00937266858581288	no	119	0.00478567461326061	67	NA	FT	RNA PROCESSING	MITOCHONDRION		Protein required for the splicing of two mitochondrial group I introns (BI3 in COB and AI5beta in COX1); forms a splicing complex, containing four subunits of Mrs1p and two subunits of the BI3-encoded maturase, that binds to the BI3 RNA	Group I intron splicing	endodeoxyribonuclease activity|RNA binding	mitochondrion
YBR101C	YBR101C	FES1	hom	Verified	2.34722073103772	0.00945702304212684	no	120	0.00914108219084405	91	NA	FT	TRANSLATION		RIBOSOME	Hsp70 (Ssa1p) nucleotide exchange factor; cytosolic homolog of Sil1p, which is the nucleotide exchange factor for BiP (Kar2p) in the endoplasmic reticulum; protein abundance increases in response to DNA replication stress	cytoplasmic translation	adenyl-nucleotide exchange factor activity	cytosol|cytosolic ribosome
YNL133C	YNL133C	FYV6	hom	Verified	2.34561962850193	0.00949774086373014	no	121	0.0230438450431782	149	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Protein of unknown function, required for survival upon exposure to K1 killer toxin; proposed to regulate double-strand break repair via non-homologous end-joining	double-strand break repair via nonhomologous end joining	molecular_function	nucleus
YLR452C	YLR452C	SST2	hom	Verified	2.34459193106164	0.00952395705453439	no	122	0.00816845199491431	74	NA	FT	SIGNALING	PLASMA MEMBRANE		GTPase-activating protein for Gpa1p, regulates desensitization to alpha factor pheromone; also required to prevent receptor-independent signaling of the mating pathway; member of the RGS (regulator of G-protein signaling) family	adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion|signal transduction	GTPase activator activity	plasma membrane
YKL118W_d	YKL118W	YKL118W	hom	Dubious	2.32845276543941	0.00994403730485325	no	123	0.0388696495230052	255	NA	FF				Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene VPH2	Unknown	Unknown	Unknown
YJL138C	YJL138C	TIF2	hom	Verified	2.31931412819537	0.0101890049637492	no	124	0.00669348891056764	85	NA	FT	TRANSLATION		RIBOSOME	Translation initiation factor eIF4A; DEA(D/H)-box RNA helicase that couples ATPase activity to RNA binding and unwinding; forms a dumbbell structure of two compact domains connected by a linker; interacts with eIF4G; protein abundance increases in response to DNA replication stress; TIF2 has a paralog, TIF1, that arose from the whole genome duplication	translational initiation|regulation of translational initiation	ATP-dependent RNA helicase activity|translation initiation factor activity	ribosome|eukaryotic translation initiation factor 4F complex|plasma membrane|cytoplasm
YJL043W_p	YJL043W	YJL043W	hom	Uncharacterized	2.31342075627515	0.0103497584926754	no	125	0.00424260652977947	45	NA	FT		MITOCHONDRION		Putative protein of unknown function; YJL043W is a non-essential gene	biological_process	molecular_function	mitochondrion|cytoplasm
YMR126C_p	YMR126C	DLT1	hom	Uncharacterized	2.2950232380678	0.0108658962950383	no	126	0.00576466927078706	85	NA					Protein of unknown function, mutant sensitive to 6-azauracil (6AU) and mycophenolic acid (MPA)	biological_process	molecular_function	cellular_component
YMR292W	YMR292W	GOT1	hom	Verified	2.27974605133483	0.0113113771612919	no	127	0.00713570372864791	81	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Homodimeric protein that is packaged into COPII vesicles and cycles between the ER and Golgi; involved in secretory transport but not directly required for aspects of transport assayed in vitro; may influence membrane composition	ER to Golgi vesicle-mediated transport|Golgi to endosome transport	molecular_function	integral to membrane|endoplasmic reticulum|Golgi apparatus|ER to Golgi transport vesicle|Golgi membrane
YMR127C	YMR127C	SAS2	hom	Verified	2.26726217474685	0.0116871073411109	no	128	0.0077534756700442	98	NA	FT	CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS|CHROMOSOME	HISTONE ACETYLTRANSFERASE	Histone acetyltransferase (HAT) catalytic subunit of the SAS complex (Sas2p-Sas4p-Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; member of the MYSTacetyltransferase family	histone acetylation|histone exchange|chromatin silencing at telomere	acetyltransferase activity|histone acetyltransferase activity	nuclear chromatin|SAS acetyltransferase complex|nuclear chromosome, telomeric region
YNL011C_p	YNL011C	YNL011C	hom	Uncharacterized	2.2634166839803	0.0118050076183344	no	129	0.00484720917298946	46	NA					Putative protein of unknown function; YNL011C is not an essential gene	biological_process	molecular_function	cellular_component
YOR084W	YOR084W	LPX1	hom	Verified	2.26091363750182	0.0118823027361578	no	130	0.00429992086710748	38	NA	FT	PEROXISOME ORGANIZATION			Oleic acid-inducible, peroxisomal matrix localized lipase; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance; peroxisomal import is dependent on the PTS1 receptor, Pex5p and on self-interaction	peroxisome organization	lipase activity	peroxisomal matrix
YBL066C	YBL066C	SEF1	hom	Verified	2.26031606780595	0.0119008207262086	no	131	0.00683884992292404	79	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Putative transcription factor, has homolog in Kluyveromyces lactis	biological_process	molecular_function	cellular_component
YOR152C_p	YOR152C	YOR152C	hom	Uncharacterized	2.25166365440868	0.0121717675726373	no	132	0.00514227378027728	26	NA					Putative protein of unknown function; YOR152C is not an essential gene	biological_process	molecular_function	membrane
YPL064C	YPL064C	CWC27	hom	Verified	2.24959985247705	0.0122371789168352	no	133	0.0164190256302913	121	NA	FT	RNA PROCESSING	NUCLEUS		Component of a complex containing Cef1p; putatively involved in pre-mRNA splicing; has similarity to S. pombe Cwf27p; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	U2-type spliceosomal complex
YDR020C_p	YDR020C	DAS2	hom	Uncharacterized	2.24681024402161	0.0123260784008466	no	134	0.0076426533357851	93	NA	FT	NUCLEOTIDE METABOLISM	NUCLEUS		Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; weak similarity with uridine kinases and with phosphoribokinases	biological_process	molecular_function	nucleus|cytoplasm
YHL010C	YHL010C	ETP1	hom	Verified	2.24125675353642	0.0125047242601208	no	135	0.00430320251003208	45	NA					Putative protein of unknown function that is required for growth on ethanol; contains a zinc finger region and has homology to human BRAP2, which is a cytoplasmic protein that binds nuclear localization sequences	response to ethanol	ubiquitin binding|nuclear localization sequence binding	cellular_component
YAL042C-A_d	YAL042C-A	YAL042C-A	hom	Dubious	2.24065005612585	0.0125243757982992	no	136	0.0125996833940572	102	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF ERV46/YAL042W; YAL042C-A is a non-essential gene	Unknown	Unknown	Unknown
YAL068C	YAL068C	PAU8	hom	Verified	2.2404670154009	0.0125303099190169	no	137	0.00618728207633762	47	NA	FT	TRANSCRIPTION FROM RNA POL II			Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions	ascospore formation|positive regulation of transcription from RNA polymerase II promoter	molecular_function	cellular_component
YBR024W	YBR024W	SCO2	hom	Verified	2.23357678590423	0.0127554663856683	no	138	0.0111937203444833	99	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Protein anchored to mitochondrial inner membrane; may have a redundant function with Sco1p in delivery of copper to cytochrome c oxidase; interacts with Cox2p; SCO2 has a paralog, SCO1, that arose from the whole genome duplication	copper ion transport	thioredoxin peroxidase activity	mitochondrial envelope|mitochondrion
YGL153W	YGL153W	PEX14	hom	Verified	2.23241541355514	0.0127937600149292	no	139	0.0120818266420169	118	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|PEROXISOME ORGANIZATION			Peroxisomal membrane peroxin that is a central component of the peroxisomal protein import machinery; interacts with both PTS1 (Pex5p) and PTS2 (Pex7p), peroxisomal matrix protein signal recognition factors and membrane receptor Pex13p	protein import into peroxisome matrix, docking	protein binding, bridging	peroxisomal membrane
YPL071C_p	YPL071C	YPL071C	hom	Uncharacterized	2.23234393058262	0.0127961202500519	no	140	0.00987254385688463	74	NA	FT		NUCLEUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus	biological_process	molecular_function	nucleus|cytoplasm
YCL051W	YCL051W	LRE1	hom	Verified	2.23089985267563	0.0128438817535676	no	141	0.0172550886211174	156	NA	FT	CELL WALL ORG/BIOGENESIS			Protein involved in control of cell wall structure and stress response; overproduction confers resistance to cell-wall degrading enzymes; exhibits genetic interactions with genes involved in the cell wall integrity pathway; <br>LRE1 has a paralog, HLR1, that arose from the whole genome duplication	fungal-type cell wall organization	molecular_function	cellular_component
YMR164C	YMR164C	MSS11	hom	Verified	2.22884250724676	0.012912192782531	no	142	0.0175040773752205	86	NA	FT	TRANSCRIPTION FROM RNA POL II|CARBOHYDRATE METABOLISM	NUCLEUS		Transcription factor involved in regulation of invasive growth and starch degradation; controls the activation of FLO11 and STA2 in response to nutritional signals	biofilm formation|Unknown|positive regulation of starch catabolic process by positive regulation of transcription from RNA polymerase II promoter|positive regulation of invasive growth in response to glucose limitation by positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YGL199C_d	YGL199C	YGL199C	hom	Dubious	2.22736860493731	0.0129613244328186	no	143	0.00605379559282111	91	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YIP4/YGL198W	Unknown	Unknown	Unknown
YML059C	YML059C	NTE1	hom	Verified	2.22723631561061	0.012965742113112	no	144	0.0124411651245741	80	NA	FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Serine esterase, homolog of human neuropathy target esterase (NTE); Nte1p-mediated phosphatidylcholine turnover influences transcription factor Opi1p localization, affecting transcriptional regulation of phospholipid biosynthesis genes	phosphatidylcholine catabolic process|regulation of phospholipid biosynthetic process	lysophospholipase activity|carboxylesterase activity	integral to membrane|endoplasmic reticulum
YJL200C	YJL200C	ACO2	hom	Verified	2.21972133471295	0.013218844845821	no	145	0.00645084160318329	54	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Putative mitochondrial aconitase isozyme; similarity to Aco1p, an aconitase required for the TCA cycle; expression induced during growth on glucose, by amino acid starvation via Gcn4p, and repressed on ethanol	biological_process	aconitate hydratase activity	mitochondrion
YKL179C	YKL179C	COY1	hom	Verified	2.21669365239758	0.0133220164245675	no	146	0.00120317206723089	26	NA	FT	VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function	Golgi vesicle transport	molecular_function	Golgi membrane
YBR066C	YBR066C	NRG2	hom	Verified	2.20444412325146	0.0137465627547288	no	147	0.00367152962025725	50	NA	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Transcriptional repressor; mediates glucose repression and negatively regulates filamentous growth; NRG2 has a paralog, NRG1, that arose from the whole genome duplication	negative regulation of transcription from RNA polymerase II promoter by glucose|biofilm formation|pseudohyphal growth|Unknown	sequence-specific DNA binding	nucleus
YMR133W	YMR133W	REC114	hom	Verified	2.20144696075413	0.0138521988014189	no	148	0.0050779715989464	43	NA	FT	CELL CYCLE	NUCLEUS|CHROMOSOME		Protein involved in early stages of meiotic recombination; possibly involved in the coordination of recombination and meiotic division; mutations lead to premature initiation of the first meiotic division	meiotic DNA double-strand break formation|reciprocal meiotic recombination	molecular_function	condensed nuclear chromosome
YER001W	YER001W	MNN1	hom	Verified	2.20120791923957	0.0138606539661447	no	149	0.00744064021674464	68	NA	FT	CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Alpha-1,3-mannosyltransferase, integral membrane glycoprotein of the Golgi complex, required for addition of alpha1,3-mannose linkages to N-linked and O-linked oligosaccharides, one of five S. cerevisiae proteins of the MNN1 family	N-glycan processing|protein O-linked glycosylation	alpha-1,3-mannosyltransferase activity	Golgi apparatus
YPR117W_p	YPR117W	YPR117W	hom	Uncharacterized	2.1960273860097	0.0140449916350616	no	150	0.0125610266413935	83	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YMR184W	YMR184W	ADD37	hom	Verified	2.18263359908524	0.0145314017045525	no	151	0.0149691057359222	89	NA	FT	PROTEOLYSIS			Protein of unknown function; involved in ER-associated protein degradation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YMR184W is not an essential gene; protein abundance increases in response to DNA replication stress	ER-associated protein catabolic process	molecular_function	cytoplasm
YJL030W	YJL030W	MAD2	hom	Verified	2.16741162586842	0.0151017407903589	no	152	0.0133989254472059	114	NA	FT	CELL CYCLE|CELL DIVISION	ENDOMEMBRANE SYSTEM|NUCLEUS|CHROMOSOME	NUCLEAR PORE|KINETOCHORE	Component of the spindle-assembly checkpoint complex; delays the onset of anaphase in cells with defects in mitotic spindle assembly; forms a complex with Mad1p; regulates APC/C activity during prometaphase and metaphase of meiosis I	chromosome decondensation|mitotic cell cycle spindle assembly checkpoint|mitotic cell cycle G2/M transition decatenation checkpoint	molecular_function	mitotic checkpoint complex|condensed nuclear chromosome kinetochore|nuclear pore
YJR105W	YJR105W	ADO1	hom	Verified	2.16433625183738	0.0152192762145708	no	153	0.0533211249012634	297	NA	FF|FT	NUCLEOTIDE METABOLISM	NUCLEUS		Adenosine kinase, required for the utilization of S-adenosylmethionine (AdoMet); may be involved in recycling adenosine produced through the methyl cycle	purine nucleobase metabolic process	adenosine kinase activity	nucleus|cytoplasm
YLR172C	YLR172C	DPH5	hom	Verified	2.1532049981984	0.0156512855214907	no	154	0.017826045136367	157	NA					Methyltransferase required for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); not essential for viability; GFP-Dph5p fusion protein localizes to the cytoplasm	peptidyl-diphthamide biosynthetic process from peptidyl-histidine	diphthine synthase activity	cytoplasm
YMR105C	YMR105C	PGM2	hom	Verified	2.14504244197057	0.0159747268694325	no	155	0.00851736476016584	67	NA	FT	ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|ION HOMEOSTASIS|GEN. OF PRECURSOR METABOLITES AND ENERGY			Phosphoglucomutase; catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism; functions as the acceptor for a Glc-phosphotransferase; protein abundance increases in response to DNA replication stress	glucose 6-phosphate metabolic process|cellular calcium ion homeostasis|galactose catabolic process|cellular cation homeostasis|glucose 1-phosphate metabolic process|trehalose biosynthetic process|UDP-glucose metabolic process|glycogen biosynthetic process	phosphoglucomutase activity	cytoplasm
YKL020C	YKL020C	SPT23	hom	Verified	2.14284846506183	0.0160626341167041	no	156	0.010839888580849	117	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|LIPID METABOLISM|GENE SILENCING	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM		ER membrane protein involved in regulation of OLE1 transcription, acts with homolog Mga2p; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting	cellular response to cold|positive regulation of unsaturated fatty acid biosynthetic process by positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|chromatin silencing at silent mating-type cassette	DNA binding	integral to endoplasmic reticulum membrane|nucleus
YDR121W	YDR121W	DPB4	hom	Verified	2.14268131204029	0.0160693484898661	no	157	0.0256773064718333	129	NA	FT	GENE SILENCING	NUCLEUS|CHROMOSOME		Subunit of DNA pol epsilon and of ISW2 chromatin accessibility complex; involved in both chromosomal DNA replication and inheritance of telomeric silencing; stabilizes the interaction of Pol epsilon with primer-template DNA, positively affecting the processivity of the polymerase and exonuclease activities of Pol epsilon; interacts with extranucleosomal DNA and acts as anchor point for ISW2 complex that retains its position on DNA during nucleosome mobilization	DNA-dependent DNA replication|chromatin silencing at telomere	double-stranded DNA binding|single-stranded DNA binding|DNA-directed DNA polymerase activity	chromatin accessibility complex|epsilon DNA polymerase complex
YMR135C	YMR135C	GID8	hom	Verified	2.14106760700796	0.0161342932349229	no	158	0.0185661381264263	126	NA	FT	KETONE METABOLISM|CELL CYCLE|CARBOHYDRATE METABOLISM|PROTEOLYSIS	NUCLEUS		Subunit of GID Complex, binds strongly to central component Vid30p; GID Complex is involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; recruits Rmd5p, Fyv10 and Vid28p to GID Complex; contains LisH, CTLH, and CRA domains that mediate binding to Vid30p (LisH) and Rmd5p and Vid28p (CTLH and CRA); dosage-dependent regulator of START	negative regulation of gluconeogenesis|proteasomal ubiquitin-dependent protein catabolic process|traversing start control point of mitotic cell cycle	molecular_function	nucleus|GID complex|cytoplasm
YIL170W	YIL170W	HXT12	hom	pseudogene	2.13014463117804	0.0165798372960366	no	159	0.0126215828551912	113	NA					Possible pseudogene in strain S288C; YIL170W/HXT12 and the adjacent ORF, YIL171W, together encode a non-functional member of the hexose transporter family	hexose transport|biological_process	hexose transmembrane transporter activity|molecular_function	integral to membrane
YLR111W_d	YLR111W	YLR111W	hom	Dubious	2.12865132816011	0.016641559248013	no	160	0.0251668466603616	259	NA	FF				Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YOL011W	YOL011W	PLB3	hom	Verified	2.12825878807149	0.0166578165098444	no	161	0.0117033391788789	90	NA	FT	LIPID METABOLISM	PLASMA MEMBRANE		Phospholipase B (lysophospholipase) involved in phospholipid metabolism; hydrolyzes phosphatidylinositol and phosphatidylserine and displays transacylase activity in vitro	phosphatidylinositol metabolic process|phosphatidylserine catabolic process	lysophospholipase activity	extracellular region|plasma membrane
YEL024W	YEL024W	RIP1	hom	Verified	2.12353760310389	0.016854413965508	no	162	0.0298268373234638	168	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Ubiquinol-cytochrome-c reductase, a Rieske iron-sulfur protein of the mitochondrial cytochrome bc1 complex; transfers electrons from ubiquinol to cytochrome c1 during respiration; during import, Rip1p is first imported into the mitochondrial matrix where it is processed, acquires its Fe-S cluster, and is folded, then is translocated into the inner membrane by the action of a homo-oligomer of Bcs1p, and finally is delivered by Bcs1p to Complex III for assembly	mitochondrial electron transport, ubiquinol to cytochrome c|aerobic respiration	ubiquinol-cytochrome-c reductase activity	mitochondrion|mitochondrial respiratory chain complex III
YDR400W	YDR400W	URH1	hom	Verified	2.12349054897538	0.0168563833165359	no	163	0.0120040624139347	85	NA	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM	NUCLEUS		Uridine nucleosidase (uridine-cytidine N-ribohydrolase), cleaves N-glycosidic bonds in nucleosides; involved in the pyrimidine salvage and nicotinamide riboside salvage pathways	pyrimidine-containing compound salvage|NAD biosynthesis via nicotinamide riboside salvage pathway|pyrimidine nucleoside catabolic process|nicotinate nucleotide salvage	ribosylpyrimidine nucleosidase activity|nicotinic acid riboside hydrolase activity|nicotinamide riboside hydrolase activity|uridine nucleosidase activity	nucleus|cytoplasm
YGR182C_d	YGR182C	YGR182C	hom	Dubious	2.11753995852785	0.0171070238771644	no	164	0.00665338274966108	70	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF TIM13/YGR181W	Unknown	Unknown	Unknown
YJL042W	YJL042W	MHP1	hom	Verified	2.11678630671029	0.0171389940115027	no	165	0.0110672525926004	64	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION	CYTOSKELETON		Microtubule-associated protein involved in assembly and stabilization of microtubules; overproduction results in cell cycle arrest at G2 phase; similar to Drosophila protein MAP and to mammalian MAP4 proteins	fungal-type cell wall organization|negative regulation of microtubule depolymerization	structural constituent of cytoskeleton	microtubule
YJL209W	YJL209W	CBP1	hom	Verified	2.11600224168608	0.0171723084586089	no	166	0.0159114391892525	151	NA	FT	RNA PROCESSING|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Mitochondrial protein, regulator of COB mRNA stability and translation; interacts with the 5'-untranslated region of the COB mRNA; found in a complex at the inner membrane along with Pet309p; localizes to mitochondrial foci upon DNA replication stress	mitochondrial mRNA catabolic process|aerobic respiration	mRNA binding	mitochondrion|extrinsic to mitochondrial inner membrane
YDR517W	YDR517W	GRH1	hom	Verified	2.11059449232354	0.0174035907412082	no	167	0.00991665834441478	77	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Acetylated cis-Golgi protein, involved in ER to Golgi transport; homolog of human GRASP65; forms a complex with the coiled-coil protein Bug1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes; protein abundance increases in response to DNA replication stress	protein secretion|ER to Golgi vesicle-mediated transport|Golgi organization	molecular_function	COPII vesicle coat|cis-Golgi network|cytoplasm
YJL135W_d	YJL135W	YJL135W	hom	Dubious	2.10860799816415	0.0174892159694569	no	168	0.00965194135617574	78	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL134W/LCB3	Unknown	Unknown	Unknown
YJL154C	YJL154C	VPS35	hom	Verified	2.10849230343259	0.0174942139038081	no	169	0.0373008240409377	242	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM		Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p	protein retention in Golgi apparatus|retrograde transport, endosome to Golgi	protein transporter activity	endosome|retromer complex, inner shell|retromer complex
YMR271C	YMR271C	URA10	hom	Verified	2.09551764240583	0.0180625009042691	no	170	0.01218893552514	120	NA	FT	NUCLEOTIDE METABOLISM			Minor orotate phosphoribosyltransferase (OPRTase) isozyme; catalyzes the fifth enzymatic step in the de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; URA10 has a paralog, URA5, that arose from the whole genome duplication	'de novo' pyrimidine nucleobase biosynthetic process|pyrimidine ribonucleoside biosynthetic process	orotate phosphoribosyltransferase activity	cytoplasm
YJR122W	YJR122W	IBA57	hom	Verified	2.09269533526314	0.0181881799702506	no	171	0.0422021987129769	260	NA	FF|FT	COFACTOR METABOLISM	MITOCHONDRION		Mitochondrial matrix protein involved in the incorporation of iron-sulfur clusters into mitochondrial aconitase-type proteins; activates the radical-SAM family members Bio2p and Lip5p; interacts with Ccr4p in the two-hybrid system	iron-sulfur cluster assembly	molecular_function	mitochondrion|mitochondrial matrix
YDR221W	YDR221W	GTB1	hom	Verified	2.09195531647848	0.0182212565171973	no	172	0.0144757521575493	112	NA	FT	CARBOHYDRATE METABOLISM	ENDOPLASMIC RETICULUM		Glucosidase II beta subunit, forms a complex with alpha subunit Rot2p; involved in removal of two glucose residues from N-linked glycans during glycoprotein biogenesis in the ER; relocalizes from ER to cytoplasm upon DNA replication stress	polysaccharide biosynthetic process|protein N-linked glycosylation	alpha-glucosidase activity	glucosidase II complex|endoplasmic reticulum|endoplasmic reticulum lumen
YIR036C_p	YIR036C	IRC24	hom	Uncharacterized	2.08713862537939	0.018437802718657	no	173	0.0191651332142589	138	NA	FT	OXIDATION-REDUCTION PROCESS			Putative benzil reductase;(GFP)-fusion protein localizes to the cytoplasm and is induced by the DNA-damaging agent MMS; sequence similarity with short-chain dehydrogenase/reductases; null mutant has increased spontaneous Rad52p foci	biological_process	molecular_function	integral to membrane|cytoplasm
YKL171W	YKL171W	NNK1	hom	Verified	2.08565692637988	0.0185048554010578	no	174	0.00788241528835217	62	NA	FT	PROTEOLYSIS|PROTEIN PHOSPHORYLATION			Protein kinase; implicated in proteasome function; interacts with TORC1, Ure2 and Gdh2; overexpression leads to hypersensitivity to rapamycin and nuclear accumulation of Gln3; epitope-tagged protein localizes to the cytoplasm	proteolysis|protein phosphorylation	protein kinase activity	cytoplasm
YER139C	YER139C	RTR1	hom	Verified	2.08397879417327	0.0185810481101061	no	175	0.0181794849463548	153	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		CTD phosphatase; dephosphorylates S5-P in the C-terminal domain of Rpo21p; has a cysteine-rich motif required for function and conserved in eukaryotes; shuttles between the nucleus and cytoplasm; RTR1 has a paralog, RTR2, that arose from the whole genome duplication	dephosphorylation of RNA polymerase II C-terminal domain|transcription from RNA polymerase II promoter	CTD phosphatase activity	nucleus|cytoplasm
YDR043C	YDR043C	NRG1	hom	Verified	2.07778159163686	0.0188647400334503	no	176	0.0119835000008392	69	NA	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Transcriptional repressor; recruits the Cyc8p-Tup1p complex to promoters; mediates glucose repression and negatively regulates a variety of processes including filamentous growth and alkaline pH response; NRG1 has a paralog, NRG2, that arose from the whole genome duplication	negative regulation of transcription from RNA polymerase II promoter by glucose|cellular hyperosmotic salinity response|biofilm formation|negative regulation of transcription from RNA polymerase II promoter|pseudohyphal growth|Unknown	RNA polymerase II repressing transcription factor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription	nucleus
YFL033C	YFL033C	RIM15	hom	Verified	2.07305303028015	0.0190836722838477	no	177	0.016813728074133	95	NA	FT	CELL CYCLE|SIGNALING|PROTEIN PHOSPHORYLATION|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		Glucose-repressible protein kinase involved in signal transduction during cell proliferation in response to nutrients, specifically the establishment of stationary phase; identified as a regulator of IME2; substrate of Pho80p-Pho85p kinase	protein phosphorylation|age-dependent response to oxidative stress involved in chronological cell aging|response to stress|regulation of meiosis	protein serine/threonine kinase activity|protein kinase activity	nucleus|cytoplasm
YNR044W	YNR044W	AGA1	hom	Verified	2.07029754057107	0.0192122448835117	no	178	0.00668806972358551	73	NA					Anchorage subunit of a-agglutinin of a-cells, highly O-glycosylated protein with N-terminal secretion signal and C-terminal signal for addition of GPI anchor to cell wall, linked to adhesion subunit Aga2p via two disulfide bonds	agglutination involved in conjugation with cellular fusion	cell adhesion molecule binding	fungal-type cell wall
YHR110W	YHR110W	ERP5	hom	Verified	2.06568728112702	0.019429008508882	no	179	0.0168290918818075	130	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport	vesicle-mediated transport	molecular_function	integral to membrane
YGL166W	YGL166W	CUP2	hom	Verified	2.06519446779274	0.019452301883453	no	180	0.0222940796016633	114	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Copper-binding transcription factor; activates transcription of the metallothionein genes CUP1-1 and CUP1-2 in response to elevated copper concentrations; CUP2 has a paralog, HAA1, that arose from the whole genome duplication	regulation of transcription from RNA polymerase II promoter|response to copper ion	RNA polymerase II core promoter proximal region sequence-specific DNA binding|copper ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity|copper ion binding	nucleus
YKL005C	YKL005C	BYE1	hom	Verified	2.06083365986584	0.0196594560239975	no	181	0.014497548059452	116	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Negative regulator of transcription elongation, contains a TFIIS-like domain and a PHD finger, multicopy suppressor of temperature-sensitive ess1 mutations, probably binds RNA polymerase II large subunit	negative regulation of transcription from RNA polymerase II promoter	methylated histone residue binding	nucleus
YHR152W	YHR152W	SPO12	hom	Verified	2.06068914692619	0.0196663528529922	no	182	0.0205474218792074	142	NA	FT	CELL CYCLE	NUCLEUS		Nucleolar protein of unknown function, positive regulator of mitotic exit; involved in regulating release of Cdc14p from the nucleolus in early anaphase, may play similar role in meiosis	regulation of exit from mitosis|mitotic cell cycle|meiosis I	molecular_function	nucleolus|nucleus
YDR495C	YDR495C	VPS3	hom	Verified	2.05575215369296	0.0199032060194762	no	183	0.0387844595533931	242	NA	FF|FT	PROTEIN LOCALIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS|VACUOLAR TRANSPORT			Component of CORVET tethering complex; cytoplasmic protein required for the sorting and processing of soluble vacuolar proteins, acidification of the vacuolar lumen, and assembly of the vacuolar H+-ATPase	vacuole inheritance|vacuolar acidification|protein targeting to vacuole	molecular_function	CORVET complex|cytoplasm
YMR253C_p	YMR253C	YMR253C	hom	Uncharacterized	2.05541199498487	0.0199196139526401	no	184	0.0167606568647387	145	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YMR253C is not an essential gene	biological_process	molecular_function	integral to membrane|cytoplasm
YML072C	YML072C	TCB3	hom	Verified	2.05493602209848	0.0199425922984464	no	185	0.0240896159605953	159	NA	FT		ENDOPLASMIC RETICULUM|MITOCHONDRION|PLASMA MEMBRANE		Cortical ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; localized to the bud via specific mRNA transport; non-tagged protein detected in a phosphorylated state in mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact	biological_process	lipid binding	mitochondrion|cortical endoplasmic reticulum|cellular bud
YFL014W	YFL014W	HSP12	hom	Verified	2.0524462702812	0.0200631558422749	no	186	0.00730513874140103	54	NA	FT	MEMBRANE ORGANIZATION|RESPONSE TO OXIDATIVE STRESS	NUCLEUS|PLASMA MEMBRANE		Plasma membrane protein involved in maintaining membrane organization in stress conditions; induced by heat shock, oxidative stress, osmostress, stationary phase, glucose depletion, oleate and alcohol; protein abundance increased in response to DNA replication stress and dietary restriction; regulated by the HOG and Ras-Pka pathways; required for dietary restriction-induced lifespan extension	cellular response to oxidative stress|cell adhesion|plasma membrane organization|cellular response to osmotic stress|cellular response to heat	lipid binding	cytosol|endosome|nucleus|plasma membrane|cytoplasm
YOR008C-A_p	YOR008C-A	YOR008C-A	hom	Uncharacterized	2.0504261805678	0.0201614302771471	no	187	0.0135429145196635	79	NA					Putative protein of unknown function, includes a potential transmembrane domain; deletion results in slightly lengthened telomeres	biological_process	molecular_function	cellular_component
YDR032C	YDR032C	PST2	hom	Verified	2.04867176626289	0.0202471109030183	no	188	0.0162951584132861	124	NA	FT	OXIDATION-REDUCTION PROCESS	MITOCHONDRION		Protein with similarity to a family of flavodoxin-like proteins; induced by oxidative stress in a Yap1p dependent manner; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; PST2 has a paralog, RFS1, that arose from the whole genome duplication	biological_process	molecular_function	mitochondrion|membrane raft|plasma membrane|cytoplasm
YLR231C	YLR231C	BNA5	hom	Verified	2.04384441974786	0.0204844596794248	no	189	0.0115804431505715	104	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM	NUCLEUS		Kynureninase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p	de novo NAD biosynthetic process from tryptophan	kynureninase activity	nucleus|cytoplasm
YMR242C	YMR242C	RPL20A	hom	Verified	2.0413971220195	0.0206056851468019	no	190	0.0242223904691599	231	NA	FF|FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L20A; homologous to mammalian ribosomal protein L18A, no bacterial homolog; RPL20A has a paralog, RPL20B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YJL188C_d	YJL188C	BUD19	hom	Dubious	2.03678154809871	0.0208359690963599	no	191	0.0183086428535918	159	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 88% of ORF overlaps the verified gene RPL39; diploid mutant displays a weak budding pattern phenotype in a systematic assay	Unknown	Unknown	Unknown
YGR161W-C_p	YGR161W-C	YGR161W-C	hom	Uncharacterized	2.03581149162801	0.0208846440266342	no	192	0.00888740497886043	67	NA					Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species	biological_process	molecular_function	cellular_component
YEL052W	YEL052W	AFG1	hom	Verified	2.03201924252104	0.0210758539768595	no	193	0.0150619684965522	111	NA	FT	PROTEIN LOCALIZATION|PROTEOLYSIS|RESPONSE TO OXIDATIVE STRESS|PEROXISOME ORGANIZATION	MITOCHONDRION		Conserved protein that may act as a chaperone in the degradation of misfolded or unassembled cytochrome c oxidase subunits; localized to matrix face of the mitochondrial inner membrane; member of the AAA family but lacks a protease domain	protein import into peroxisome matrix|cellular response to oxidative stress|misfolded or incompletely synthesized protein catabolic process	molecular_function	mitochondrion|mitochondrial inner membrane
YOR015W_d	YOR015W	YOR015W	hom	Dubious	2.03140440984783	0.0211069937287378	no	194	0.0164687024236193	122	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YEL010W_d	YEL010W	YEL010W	hom	Dubious	2.02437846225538	0.0214656130372378	no	195	0.0106173049783243	91	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YOR001W	YOR001W	RRP6	hom	Verified	2.02136636327983	0.0216209270078991	no	196	0.00766200447203162	80	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|RNA LOCALIZATION	NUCLEUS		Nuclear exosome exonuclease component; has 3'-5' exonuclease activity; involved in RNA processing, maturation, surveillance, degradation, tethering, and export; has similarity to E. coli RNase D and to human PM-Sc1 100 (EXOSC10); mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay	nuclear polyadenylation-dependent rRNA catabolic process|nuclear polyadenylation-dependent snRNA catabolic process|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|histone mRNA catabolic process|nuclear polyadenylation-dependent antisense transcript catabolic process|U1 snRNA 3'-end processing|polyadenylation-dependent snoRNA 3'-end processing|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|U5 snRNA 3'-end processing|nuclear polyadenylation-dependent tRNA catabolic process|nuclear polyadenylation-dependent CUT catabolic process|nuclear polyadenylation-dependent snoRNA catabolic process|nuclear retention of pre-mRNA at the site of transcription|nuclear polyadenylation-dependent mRNA catabolic process|U4 snRNA 3'-end processing|nuclear retention of pre-mRNA with aberrant 3'-ends at the site of transcription	3'-5'-exoribonuclease activity	nucleolus|nucleus|nuclear exosome (RNase complex)
YLR290C_p	YLR290C	YLR290C	hom	Uncharacterized	2.02050075623912	0.021665735889893	no	197	0.011008747340894	84	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YLR290C is not an essential gene	biological_process	molecular_function	mitochondrion
YJL185C	YJL185C	ATG36	hom	Verified	2.01928321861857	0.0217288955362942	no	198	0.0176178856474436	138	NA					Pex3p interacting protein, required for pexophagy; interacts with Atg8p and Atg11p; mRNA is weakly cell cycle regulated, peaking in G2 phase; YJL185C is a non-essential gene	peroxisome degradation	molecular_function	peroxisome
YIL079C	YIL079C	AIR1	hom	Verified	2.01751593769589	0.0218208497596319	no	199	0.0247050285218467	157	NA	FT	RNA PROCESSING	NUCLEUS		Zinc knuckle protein; involved in nuclear RNA processing and degradation as a component of the TRAMP complex; stimulates the poly(A) polymerase activity of Pap2p in vitro; AIR1 has a paralog, AIR2, that arose from the whole genome duplication	nuclear mRNA surveillance of mRNA 3'-end processing|nuclear polyadenylation-dependent tRNA catabolic process|nuclear polyadenylation-dependent CUT catabolic process|nuclear polyadenylation-dependent snoRNA catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|ncRNA polyadenylation|nuclear polyadenylation-dependent snRNA catabolic process	polynucleotide adenylyltransferase activity	nucleolus|TRAMP complex
YCL076W_d	YCL076W	YCL076W	hom	Dubious	2.01220087002191	0.0220993834151638	no	200	0.0109402601891583	90	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YJL073W	YJL073W	JEM1	hom	Verified	2.00943021749156	0.0222457641509467	no	201	0.0253387445628353	208	NA	FT	PROTEOLYSIS	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM		DnaJ-like chaperone required for nuclear membrane fusion during mating, localizes to the ER membrane; exhibits genetic interactions with KAR2	karyogamy involved in conjugation with cellular fusion|ER-associated protein catabolic process|protein folding in endoplasmic reticulum	unfolded protein binding|chaperone binding	endoplasmic reticulum|nuclear outer membrane-endoplasmic reticulum membrane network
YER150W	YER150W	SPI1	hom	Verified	2.00562293390094	0.0224482465706243	no	202	0.0239613829362681	161	NA					GPI-anchored cell wall protein involved in weak acid resistance; basal expression requires Msn2p/Msn4p; expression is induced under conditions of stress and during the diauxic shift; similar to Sed1p	response to acid	molecular_function	fungal-type cell wall
YHR180W_d	YHR180W	YHR180W	hom	Dubious	2.00549941068369	0.0224548418410711	no	203	0.0169081188609783	115	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YKL008C	YKL008C	LAC1	hom	Verified	2.00128173148498	0.022681018667945	no	204	0.0193078426144863	136	NA	FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Ceramide synthase component, involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lag1p	replicative cell aging|ceramide biosynthetic process	sphingosine N-acyltransferase activity	integral to membrane|endoplasmic reticulum
YNL311C	YNL311C	SKP2	hom	Verified	1.9938036542315	0.023086758041102	no	205	0.0157117354471803	88	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|PROTEOLYSIS		UBIQUITIN LIGASE COMPLEX	F-box protein of unknown function predicted to be part of an SCF ubiquitin protease complex; involved in regulating protein levels of sulfur metabolism enzymes; may interact with ribosomes, based on co-purification experiments	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|cellular protein catabolic process|regulation of sulfur amino acid metabolic process	ubiquitin-protein ligase activity|protein binding, bridging	ribosome|SCF ubiquitin ligase complex
YDR034C	YDR034C	LYS14	hom	Verified	1.98051347777507	0.0238229302081881	no	206	0.0231245286917989	143	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Transcriptional activator involved in regulation of genes of the lysine biosynthesis pathway; requires 2-aminoadipate semialdehyde as co-inducer	Unknown|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YGL221C	YGL221C	NIF3	hom	Verified	1.98021247615758	0.0238398292742201	no	207	0.019018791028179	132	NA	FT		MITOCHONDRION		Protein of unknown function, similar to Listeria monocytogenes major sigma factor (rpoD gene product); the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion|cytoplasm
YDR488C	YDR488C	PAC11	hom	Verified	1.97341573048825	0.0242241084323567	no	208	0.013010586354644	100	NA	FT		CYTOSKELETON		Dynein intermediate chain, acts in the cytoplasmic dynein pathway, forms cortical cytoplasmic microtubule capture site with Num1p; null mutant is defective in nuclear migration, essential in the absence of CIN8	nuclear migration along microtubule|microtubule-based process	plus-end-directed microtubule motor activity|microtubule motor activity	cytoplasmic dynein complex|cytoplasmic microtubule
YBR030W	YBR030W	RKM3	hom	Verified	1.96993304878762	0.0244230220913824	no	209	0.0155789363919389	120	NA	FT		NUCLEUS		Ribosomal lysine methyltransferase specific for monomethylation of Rpl42ap and Rpl42bp (lysine 40); nuclear SET domain containing protein	peptidyl-lysine monomethylation	protein-lysine N-methyltransferase activity	nucleus
YDL229W	YDL229W	SSB1	hom	Verified	1.96977393489031	0.0244321425524752	no	210	0.013541429598398	105	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RESPONSE TO NUTRIENT LEVELS			Cytoplasmic ATPase that is a ribosome-associated molecular chaperone; functions with J-protein partner Zuo1p; may be involved in folding of newly-made polypeptide chains; member of the HSP70 family; interacts with phosphatase subunit Reg1p; SSB1 has a paralog, SSB2, that arose from the whole genome duplication	cytoplasmic translation|cellular response to glucose starvation|translational termination|ribosomal subunit export from nucleus|regulation of translational fidelity|rRNA processing|'de novo' cotranslational protein folding	unfolded protein binding|ATPase activity|calmodulin binding	plasma membrane|polysome|cytoplasm
YML116W-A_d	YML116W-A	YML116W-A	hom	Dubious	1.96872485995627	0.0244923474705016	no	211	0.00945479979053247	74	NA					Putative protein of unknown function	Unknown	Unknown	Unknown
YKL212W	YKL212W	SAC1	hom	Verified	1.96853793597927	0.0245030878312154	no	212	0.0986897869512632	493	NA	FF|FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION|GOLGI APPARATUS		Phosphatidylinositol phosphate (PtdInsP) phosphatase; involved in hydrolysis of PtdIns[4]P in the early and medial Golgi; regulated by interaction with Vps74p; ER localized transmembrane protein which cycles through the Golgi; involved in protein trafficking and processing, secretion, and cell wall maintenance; regulates sphingolipid biosynthesis through the modulation of PtdIns(4)P metabolism	phosphatidylinositol dephosphorylation	phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity|phosphatidylinositol-3-phosphatase activity|phosphatidylinositol-4-phosphate phosphatase activity	mitochondrial outer membrane|integral to endoplasmic reticulum membrane|mitochondrion|SPOTS complex|integral to Golgi membrane
YGR055W	YGR055W	MUP1	hom	Verified	1.96822691653874	0.0245209672848218	no	213	0.0261419037581083	144	NA	FT		PLASMA MEMBRANE		High affinity methionine permease, integral membrane protein with 13 putative membrane-spanning regions; also involved in cysteine uptake	cysteine transport|sulfur amino acid transport|methionine transport	L-methionine secondary active transmembrane transporter activity	integral to membrane|integral to plasma membrane
YHR098C	YHR098C	SFB3	hom	Verified	1.96244652653055	0.024855260224133	no	214	0.0332014369354095	235	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS|SITE OF POLARIZED GROWTH		Component of the Sec23p-Sfb3p heterodimer of the COPII vesicle coat, required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sec24p and Sfb2p	cargo loading into COPII-coated vesicle	signal sequence binding	COPII vesicle coat|mating projection tip
YJL193W_p	YJL193W	YJL193W	hom	Uncharacterized	1.96229024723537	0.0248643510102592	no	215	0.0221089032133359	149	NA					Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect	biological_process	molecular_function	integral to membrane
YOR045W	YOR045W	TOM6	hom	Verified	1.95968461733073	0.0250163321067498	no	216	0.0224810952234611	162	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex	mitochondrial outer membrane translocase complex assembly|protein import into mitochondrial matrix	protein channel activity	mitochondrion|integral to membrane|mitochondrial outer membrane translocase complex
YOL058W	YOL058W	ARG1	hom	Verified	1.9477956364122	0.0257197105641006	no	217	0.0369009880545646	191	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Arginosuccinate synthetase, catalyzes the formation of L-argininosuccinate from citrulline and L-aspartate in the arginine biosynthesis pathway; potential Cdc28p substrate	argininosuccinate metabolic process|arginine biosynthetic process|citrulline metabolic process	argininosuccinate synthase activity	cytosol
YBL015W	YBL015W	ACH1	hom	Verified	1.94133112442938	0.0261090633128519	no	218	0.0205889573491009	90	NA	FT	KETONE METABOLISM|COFACTOR METABOLISM	MITOCHONDRION		Protein with CoA transferase activity, particularly for CoASH transfer from succinyl-CoA to acetate; has minor acetyl-CoA-hydrolase activity; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth	acetate metabolic process	acetate CoA-transferase activity|acetyl-CoA hydrolase activity	cytosol|mitochondrion
YPL119C-A_p	YPL119C-A	YPL119C-A	hom	Uncharacterized	1.93816030728769	0.0263018338413622	no	219	0.0238797904138932	139	NA					Putative protein of unknown function; identified by expression profiling and mass spectrometry	biological_process	molecular_function	cellular_component
YDR431W_d	YDR431W	YDR431W	hom	Dubious	1.93738892392833	0.0263489097689209	no	220	0.0144353489286161	108	NA					Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YBR221W-A_p	YBR221W-A	YBR221W-A	hom	Uncharacterized	1.93682196568638	0.0263835549418029	no	221	0.0209577672743549	131	NA					Putative protein of unknown function; identified by expression profiling and mass spectrometry	biological_process	molecular_function	cellular_component
YGL060W	YGL060W	YBP2	hom	Verified	1.93175492643839	0.0266948808981752	no	222	0.0284522439098919	237	NA	FT	CELL CYCLE	NUCLEUS|CHROMOSOME	KINETOCHORE	Central kinetochore associated protein; mediates mitotic progression; interacts with several central kinetochore proteins and centromeric histone Cse4p; role in resistance to oxidative stress; similar to Slk19p; YBP2 has a paralog, YBP1, that arose from the whole genome duplication	G2/M transition of mitotic cell cycle	molecular_function	condensed nuclear chromosome kinetochore|centromere-specific nucleosome|cytoplasm
YLR193C	YLR193C	UPS1	hom	Verified	1.92768414676571	0.0269472125821681	no	223	0.0198250644299683	126	NA	FT	LIPID METABOLISM	MITOCHONDRION		Phosphatidic acid transfer protein; plays a role in phospholipid metabolism by transporting phosphatidic acid from the outer to the inner mitochondrial membrane; localizes to the mitochondrial intermembrane space; null mutant has altered cardiolipin and phosphatidic acid levels; ortholog of human PRELI	Unknown|cardiolipin metabolic process	molecular_function	mitochondrion|extrinsic to mitochondrial inner membrane|mitochondrial intermembrane space
YGR141W	YGR141W	VPS62	hom	Verified	1.92244069936469	0.0272751642889603	no	224	0.020495222719943	110	NA	FT	PROTEIN LOCALIZATION|VACUOLAR TRANSPORT			Vacuolar protein sorting (VPS) protein required for cytoplasm to vacuole targeting of proteins	protein targeting to vacuole	molecular_function	cellular_component
YKR023W_p	YKR023W	YKR023W	hom	Uncharacterized	1.91934780530761	0.0274701658754176	no	225	0.0130827591122456	83	NA	FT		NUCLEUS|MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion|cytoplasm
YGL161C	YGL161C	YIP5	hom	Verified	1.91928558362837	0.0274741007407578	no	226	0.030778596785272	206	NA	FT		GOLGI APPARATUS		Protein that interacts with Rab GTPases, localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport	biological_process	Rab GTPase binding	integral to membrane|Golgi apparatus
YDL040C	YDL040C	NAT1	hom	Verified	1.91487933088803	0.0277539471587308	no	227	0.0298416630852453	213	NA	FT		MITOCHONDRION	RIBOSOME	Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing	N-terminal protein amino acid acetylation	peptide alpha-N-acetyltransferase activity	mitochondrion|NatA complex|cytosolic ribosome
YMR160W	YMR160W	YMR160W	hom	Verified	1.91264355870541	0.0278968496517229	no	228	0.0293385925808601	180	NA					Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the membrane of the vacuole; mutant has enhanced sensitivity to overexpression of mutant huntingtin; YMR160W is not an essential gene; relative distribution within the vacuolar membrane changes upon DNA replication stress	biological_process	molecular_function	fungal-type vacuole membrane
YML070W	YML070W	DAK1	hom	Verified	1.9094853644643	0.0280997539805542	no	229	0.0114639958344733	72	NA	FT	CARBOHYDRATE METABOLISM			Dihydroxyacetone kinase, required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation	response to stress|glycerol catabolic process	glycerone kinase activity	cytoplasm
YOL158C	YOL158C	ENB1	hom	Verified	1.9085532730659	0.0281598723269617	no	230	0.0259040248504657	115	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Endosomal ferric enterobactin transporter, expressed under conditions of iron deprivation; member of the major facilitator superfamily; expression is regulated by Rcs1p and affected by chloroquine treatment	ferric-enterobactin transport	ferric-enterobactin transmembrane transporter activity	integral to membrane|cellular bud membrane|plasma membrane
YNL303W_d	YNL303W	YNL303W	hom	Dubious	1.90768980238424	0.0282156602599643	no	231	0.0197334409793398	144	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YPL262W	YPL262W	FUM1	hom	Verified	1.90765799223859	0.0282177172358803	no	232	0.0295403023998535	178	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Fumarase, converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial distribution determined by the N-terminal targeting sequence, protein conformation, and status of glyoxylate shunt; phosphorylated in mitochondria	fumarate metabolic process|tricarboxylic acid cycle	fumarate hydratase activity	cytosol|mitochondrion|mitochondrial matrix
YNL115C_p	YNL115C	YNL115C	hom	Uncharacterized	1.90455425415343	0.0284190189293447	no	233	0.0218669165777192	163	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL115C is not an essential gene	biological_process	molecular_function	integral to membrane|fungal-type vacuole
YJL163C_p	YJL163C	YJL163C	hom	Uncharacterized	1.9024912902058	0.0285534782220958	no	234	0.0252419949654378	156	NA					Putative protein of unknown function	biological_process	molecular_function	integral to membrane
YMR025W	YMR025W	CSI1	hom	Verified	1.90187255681136	0.0285939088635676	no	235	0.0235347964012857	128	NA	FT	SIGNALING	NUCLEUS		Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling; functional equivalent of canonical Csn6 subunit of the COP9 signalosome	adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion|cullin deneddylation	molecular_function	signalosome
YDL189W	YDL189W	RBS1	hom	Verified	1.90097355604589	0.0286527381983315	no	236	0.023328663047685	150	NA	FT	CARBOHYDRATE METABOLISM			Protein of unknown function, identified as a high copy suppressor of psk1 psk2 mutations that confer temperature-sensitivity for galactose utilization; proposed to bind single-stranded nucleic acids via its R3H domain	galactose metabolic process	molecular_function	cytoplasm
YMR272W-B_p	YMR272W-B	YMR272W-B	hom	Uncharacterized	1.89741233244364	0.0288867696225631	no	237	0.0143211187351599	93	NA					Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching	biological_process	molecular_function	cellular_component
YDL171C	YDL171C	GLT1	hom	Verified	1.8973739808199	0.0288892985820255	no	238	0.0244276728834118	131	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS	MITOCHONDRION		NAD(+)-dependent glutamate synthase (GOGAT), synthesizes glutamate from glutamine and alpha-ketoglutarate; with Gln1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source	glutamate biosynthetic process|ammonia assimilation cycle	glutamate synthase (NADH) activity	mitochondrion
YDR193W_d	YDR193W	YDR193W	hom	Dubious	1.89723524678055	0.0288984484347591	no	239	0.0153732617885129	103	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YOR330C	YOR330C	MIP1	hom	Verified	1.89699084065619	0.0289145734822634	no	240	0.0165862384405464	128	NA	FT	MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit	mitochondrial DNA replication	3'-5' exonuclease activity|DNA-directed DNA polymerase activity	mitochondrion
YOR365C_p	YOR365C	YOR365C	hom	Uncharacterized	1.89164682708927	0.0292690261712455	no	241	0.0209815649978198	171	NA					Putative protein of unknown function; not an essential protein; YOR365C has a paralog, FLC2, that arose from the whole genome duplication	biological_process	molecular_function	integral to membrane
YJL071W	YJL071W	ARG2	hom	Verified	1.88903765463734	0.0294433916736816	no	242	0.021319650289809	160	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		Acetylglutamate synthase (glutamate N-acetyltransferase), mitochondrial enzyme that catalyzes the first step in the biosynthesis of the arginine precursor ornithine; forms a complex with Arg5,6p	arginine biosynthetic process|ornithine biosynthetic process	acetyl-CoA:L-glutamate N-acetyltransferase activity	mitochondrial matrix
YHL038C	YHL038C	CBP2	hom	Verified	1.8877042589579	0.0295328321496966	no	243	0.0166726271664798	111	NA	FT	RNA PROCESSING	MITOCHONDRION		Required for splicing of the group I intron bI5 of the COB pre-mRNA; nuclear-encoded mitochondrial protein that binds to the RNA to promote splicing; also involved in but not essential for splicing of the COB bI2 intron and the intron in the 21S rRNA gene	Group I intron splicing	RNA binding	mitochondrion
YMR085W_p	YMR085W	YMR085W	hom	Uncharacterized	1.8856485058443	0.0296711681582027	no	244	0.0319489000333478	187	NA	FT	CARBOHYDRATE METABOLISM			Putative protein of unknown function; YMR085W and adjacent ORF YMR084W are merged in related strains, and together are paralogous to glutamine-fructose-6-phosphate amidotransferase GFA1	biological_process	molecular_function	cellular_component
YOR268C_p	YOR268C	YOR268C	hom	Uncharacterized	1.88505178069857	0.0297114236138336	no	245	0.0118582703168844	83	NA					Putative protein of unknown function; sporulation is abnormal in homozygous diploid; YOR268C is not an essential gene	biological_process	molecular_function	cellular_component
YKL001C	YKL001C	MET14	hom	Verified	1.88091023927676	0.0299920650609749	no	246	0.0225948708091528	104	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Adenylylsulfate kinase, required for sulfate assimilation and involved in methionine metabolism	sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)|sulfur amino acid metabolic process	adenylylsulfate kinase activity	cytoplasm
YKR035W-A	YKR035W-A	DID2	hom	Verified	1.87908235440304	0.0301166245658118	no	247	0.0306457972507271	154	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM		Class E protein of the vacuolar protein-sorting (Vps) pathway; binds Vps4p and directs it to dissociate ESCRT-III complexes; forms a functional and physical complex with Ist1p; human ortholog may be altered in breast tumors	late endosome to vacuole transport via multivesicular body sorting pathway|late endosome to vacuole transport|protein targeting to vacuole	molecular_function	late endosome|cytoplasm
YBL036C	YBL036C	YBL036C	hom	Verified	1.87566155120401	0.0303508843361129	no	248	0.0165811933605814	65	NA					Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS	biological_process	pyridoxal phosphate binding	cellular_component
YHR067W	YHR067W	HTD2	hom	Verified	1.87482803576442	0.0304081924517432	no	249	0.0516334325526087	286	NA	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS	MITOCHONDRION		Mitochondrial 3-hydroxyacyl-thioester dehydratase involved in fatty acid biosynthesis, required for respiratory growth and for normal mitochondrial morphology	fatty acid biosynthetic process	3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity	mitochondrion
YIL164C	YIL164C	NIT1	hom	Verified	1.87097654092113	0.030674166342488	no	250	0.0225357291964042	164	NA					Nitrilase, member of the nitrilase branch of the nitrilase superfamily; in closely related species and other S. cerevisiae strain backgrounds YIL164C and adjacent ORF, YIL165C, likely constitute a single ORF encoding a nitrilase gene	biological_process	nitrilase activity	cellular_component
YGL059W	YGL059W	PKP2	hom	Verified	1.85873438359608	0.0315323986210564	no	251	0.0309847212980923	161	NA	FT	CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION	MITOCHONDRION		Mitochondrial protein kinase; negatively regulates activity of the pyruvate dehydrogenase complex by phosphorylating the ser-133 residue of the Pda1p subunit; acts in concert with kinase Pkp1p and phosphatases Ptc5p and Ptc6p; relocalizes from mitochondrion to cytoplasm upon DNA replication stress	peptidyl-serine phosphorylation|protein phosphorylation|carbon utilization|negative regulation of catalytic activity	protein kinase activity|pyruvate dehydrogenase (acetyl-transferring) kinase activity	mitochondrion
YHR030C	YHR030C	SLT2	hom	Verified	1.85798013709747	0.0315859175234474	no	252	0.102241315788034	539	NA	FF|FT	PROTEIN LOCALIZATION|RNA PROCESSING|SIGNALING|CELL WALL ORG/BIOGENESIS|CELL DIVISION|PROTEIN PHOSPHORYLATION|PEROXISOME ORGANIZATION	NUCLEUS|SITE OF POLARIZED GROWTH		Serine/threonine MAP kinase; involved in regulating maintenance of cell wall integrity, progression through the cell cycle, and nuclear mRNA retention in heat shock; required for mitophagy and pexophagy; affects recruitment of mitochondria to the phagophore assembly site (PAS); regulated by the PKC1-mediated signaling pathway	protein phosphorylation|endoplasmic reticulum unfolded protein response|signal transduction|UFP-specific transcription factor mRNA processing involved in endoplasmic reticulum unfolded protein response|fungal-type cell wall organization|peroxisome degradation|regulation of transcription factor import into nucleus|barrier septum assembly|response to acid|regulation of cell size	MAP kinase activity|protein serine/threonine kinase activity|protein kinase activity	nucleus|cytoplasm|cellular bud tip
YDL157C_p	YDL157C	YDL157C	hom	Uncharacterized	1.85792531428773	0.031589810498441	no	253	0.014296953756683	61	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YCR060W	YCR060W	TAH1	hom	Verified	1.85665281525657	0.031680282306051	no	254	0.0235430226999803	130	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS	NUCLEUS		Component of the conserved R2TP complex (Rvb1-Rvb2-Tah1-Pih1); contains a single TPR domain with at least two TPR motifs; R2TP complex interacts with Hsp90 (Hsp82p and Hsc82p) to mediate assembly large protein complexes such as box C/D snoRNPs and RNA polymerase II	protein folding|box C/D snoRNP assembly	chaperone binding	R2TP complex|nucleus|cytoplasm
YBR156C	YBR156C	SLI15	hom	Verified	1.85611089845238	0.0317188763201525	no	255	0.0292030174317955	181	NA	FT	CELL DIVISION|PROTEIN PHOSPHORYLATION|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME|CYTOSKELETON		Subunit of the conserved chromosomal passenger complex (CPC; Ipl1p-Sli15p-Bir1p-Nbl1p), which regulates kinetochore-microtubule attachments, activation of the spindle tension checkpoint, and mitotic spindle disassembly	chromosome segregation|protein phosphorylation|regulation of cytokinesis	protein kinase activator activity	spindle microtubule|spindle midzone|chromosome passenger complex|kinetochore microtubule
YBR001C	YBR001C	NTH2	hom	Verified	1.85458428952237	0.0318278066525597	no	256	0.0423694363321513	300	NA	FF|FT	CARBOHYDRATE METABOLISM	MITOCHONDRION		Putative neutral trehalase, required for thermotolerance; may mediate resistance to other cellular stresses; NTH2 has a paralog, NTH1, that arose from the whole genome duplication	trehalose catabolic process	alpha,alpha-trehalase activity	mitochondrion|cytoplasm
YFR025C	YFR025C	HIS2	hom	Verified	1.85378676176856	0.0318848365806765	no	257	0.0229042770571158	120	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Histidinolphosphatase, catalyzes the eighth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control	histidine biosynthetic process	histidinol-phosphatase activity	intracellular
YAL014C	YAL014C	SYN8	hom	Verified	1.85290032205715	0.0319483234765311	no	258	0.018453236218637	134	NA	FT	PROTEIN LOCALIZATION			Endosomal SNARE related to mammalian syntaxin 8	transport	SNAP receptor activity	endosome
YPL081W	YPL081W	RPS9A	hom	Verified	1.85194424452327	0.032016914825176	no	259	0.032121129059431	199	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION	NUCLEUS	RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S9 and bacterial S4; RPS9A has a paralog, RPS9B, that arose from the whole genome duplication	cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome|rRNA binding	small-subunit processome|cytosolic small ribosomal subunit|90S preribosome|cytoplasm
YOR100C	YOR100C	CRC1	hom	Verified	1.8503661095873	0.0321304000876402	no	260	0.01985743067749	153	NA	FT	KETONE METABOLISM|LIPID METABOLISM	MITOCHONDRION		Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation	fatty acid metabolic process	carnitine:acyl carnitine antiporter activity	mitochondrion|integral to membrane|mitochondrial inner membrane
YOL013W-B_d	YOL013W-B	YOL013W-B	hom	Dubious	1.84937554651373	0.0322018019582635	no	261	0.017723743418058	147	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the long terminal repeat (LTR) of a Ty1 element	Unknown	Unknown	Unknown
YJR058C	YJR058C	APS2	hom	Verified	1.84875365847419	0.0322466958448591	no	262	0.0136761669161711	73	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|PLASMA MEMBRANE		Small subunit of the clathrin-associated adaptor complex AP-2, which is involved in protein sorting at the plasma membrane; related to the sigma subunit of the mammalian plasma membrane clathrin-associated protein (AP-2) complex	vesicle-mediated transport	molecular_function	AP-2 adaptor complex
YNR001C	YNR001C	CIT1	hom	Verified	1.84251154950478	0.0327001793511914	no	263	0.03801910837575	231	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Citrate synthase; catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate; the rate-limiting enzyme of the TCA cycle; nuclear encoded mitochondrial protein; CIT1 has a paralog, CIT2, that arose from the whole genome duplication	glutamate biosynthetic process|tricarboxylic acid cycle|acetyl-CoA catabolic process|citrate metabolic process	citrate (Si)-synthase activity	mitochondrion
YML100W	YML100W	TSL1	hom	Verified	1.83926880074046	0.032937829784935	no	264	0.0185218783275763	111	NA	FT	CARBOHYDRATE METABOLISM			Large subunit of trehalose 6-phosphate synthase/phosphatase complex; Tps1p-Tps2p complex converts uridine-5'-diphosphoglucose and glucose 6-phosphate to trehalose; mutant has aneuploidy tolerance; protein abundance increases in response to DNA replication stress; TSL1 has a paralog, TPS3, that arose from the whole genome duplication	trehalose biosynthetic process|response to stress	enzyme regulator activity|alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity|trehalose-phosphatase activity	alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)
YJL213W	YJL213W	YJL213W	hom	Verified	1.83869391938424	0.0329801091422733	no	265	0.0255000893595905	146	NA					Protein of unknown function that may interact with ribosomes; periodically expressed during the yeast metabolic cycle; phosphorylated in vitro by the mitotic exit network (MEN) kinase complex, Dbf2p/Mob1p	biological_process	molecular_function	ribosome
YDR491C_d	YDR491C	YDR491C	hom	Dubious	1.83631283875552	0.0331557010160852	no	266	0.0210392096422008	120	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YML107C	YML107C	PML39	hom	Verified	1.8353988458066	0.0332233073090138	no	267	0.029322138322038	131	NA	FT	RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	Protein required for nuclear retention of unspliced pre-mRNAs along with Mlp1p and Pml1p; anchored to nuclear pore complex via Mlp1p and Mlp2p; found with the subset of nuclear pores farthest from the nucleolus; may interact with ribosomes	maintenance of RNA location	molecular_function	ribosome|nuclear pore
YPL219W	YPL219W	PCL8	hom	Verified	1.83534527751628	0.0332272731719084	no	268	0.0439363467279781	200	NA	FT	CELL CYCLE|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS		Cyclin, interacts with Pho85p cyclin-dependent kinase (Cdk) to phosphorylate and regulate glycogen synthase, also activates Pho85p for Glc8p phosphorylation	negative regulation of glycogen biosynthetic process	cyclin-dependent protein kinase regulator activity	cyclin-dependent protein kinase holoenzyme complex
YOR028C	YOR028C	CIN5	hom	Verified	1.8336496662529	0.0333530073329544	no	269	0.0230690286086564	123	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Basic leucine zipper (bZIP) transcription factor of the yAP-1 family; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; mediates pleiotropic drug resistance and salt tolerance; nuclearly localized under oxidative stress and sequestered in the cytoplasm by Lot6p under reducing conditions; CIN5 has a paralog, YAP6, that arose from the whole genome duplication	hyperosmotic salinity response|response to drug|hyperosmotic response|regulation of transcription from RNA polymerase II promoter	repressing transcription factor binding|sequence-specific DNA binding	nucleus|cytoplasm
YPL183C	YPL183C	RTT10	hom	Verified	1.83339982301519	0.0333715669603289	no	270	0.0362282858766802	201	NA	FT	VESICLE-MEDIATED TRANSPORT			WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rrt2p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; evidence it interacts with Trm7p for 2'-O-methylation of N34 of substrate tRNAs; has a role in regulation of Ty1 transposition; human ortholog is WDR6	endocytic recycling	molecular_function	endosome|cytoplasm
YEL049W	YEL049W	PAU2	hom	Verified	1.831660148098	0.0335010347647522	no	271	0.0201309965038218	68	NA					Member of the seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme	biological_process	molecular_function	cellular_component
YDL070W	YDL070W	BDF2	hom	Verified	1.83143261193622	0.0335179986990652	no	272	0.0286090416149953	182	NA	FT	CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE	NUCLEUS		Protein involved in transcription initiation; acts at TATA-containing promoters; associates with the basal transcription factor TFIID; contains two bromodomains; corresponds to the C-terminal region of mammalian TAF1; redundant with Bdf1p; protein abundance increases in response to DNA replication stress	negative regulation of heterochromatin assembly	histone acetyl-lysine binding|core promoter binding|histone binding|TFIID-class transcription factor binding	nucleus
YKL166C	YKL166C	TPK3	hom	Verified	1.82848523109208	0.0337383801020506	no	273	0.0190622977060225	122	NA	FT	SIGNALING|MITOCHONDRION ORGANIZATION|PROTEIN PHOSPHORYLATION	NUCLEUS		cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk2p; localizes to P-bodies during stationary phase; TPK3 has a paralog, TPK1, that arose from the whole genome duplication	protein phosphorylation|mitochondrion organization|Ras protein signal transduction	cAMP-dependent protein kinase activity|protein kinase activity	cAMP-dependent protein kinase complex|nucleus|cytoplasm
YIR003W	YIR003W	AIM21	hom	Verified	1.82702717016119	0.0338478421628066	no	274	0.0262107733355656	160	NA	FT		SITE OF POLARIZED GROWTH|CYTOSKELETON		Protein of unknown function involved in mitochondrial migration along actin filament; may interact with ribosomes; GFP-fusion protein colocalizes with Sac1p to the actin cytoskeleton	mitochondrion migration along actin filament	molecular_function	ribosome|mating projection tip|actin cytoskeleton
YKL175W	YKL175W	ZRT3	hom	Verified	1.82659141820876	0.033880612329571	no	275	0.0257547668033381	115	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Vacuolar membrane zinc transporter, transports zinc from storage in the vacuole to the cytoplasm when needed; transcription is induced under conditions of zinc deficiency	cellular zinc ion homeostasis|zinc ion transport	zinc ion transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane
YHR123W	YHR123W	EPT1	hom	Verified	1.81591081723573	0.0346920268485981	no	276	0.0222021433689213	132	NA	FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferase; not essential for viability; EPT1 has a paralog, CPT1, that arose from the whole genome duplication	phosphatidylethanolamine biosynthetic process|phosphatidylcholine biosynthetic process	ethanolaminephosphotransferase activity|diacylglycerol cholinephosphotransferase activity	integral to membrane|Golgi apparatus
YML090W_d	YML090W	YML090W	hom	Dubious	1.81277919166169	0.034932942290192	no	277	0.0319214441935093	165	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YML089C; exhibits growth defect on a non-fermentable (respiratory) carbon source	Unknown	Unknown	Unknown
YLR390W	YLR390W	ECM19	hom	Verified	1.81199318315187	0.0349936249082322	no	278	0.053071322436284	251	NA	FT	CELL WALL ORG/BIOGENESIS	MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	fungal-type cell wall organization	molecular_function	mitochondrion
YNL068C	YNL068C	FKH2	hom	Verified	1.81096758564704	0.035072934702378	no	279	0.0265675837845232	181	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|MITOCHONDRION ORGANIZATION|GENE SILENCING	NUCLEUS|CHROMOSOME		Forkhead family transcription factor; plays a major role in the expression of G2/M phase genes; positively regulates transcriptional elongation; negative role in chromatin silencing at HML and HMR; substrate of the Cdc28p/Clb5p kinase; FKH2 has a paralog, FKH1, that arose from the whole genome duplication	negative regulation of chromatin silencing at silent mating-type cassette|positive regulation of transcription elongation from RNA polymerase II promoter|positive regulation of transcription involved in G2/M-phase of mitotic cell cycle|negative regulation of transcription involved in G1 phase of mitotic cell cycle|Unknown|chromatin remodeling|negative regulation of transcription involved in G2/M-phase of mitotic cell cycle	RNA polymerase II transcription factor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II transcription factor binding transcription factor activity	nucleus
YMR110C	YMR110C	HFD1	hom	Verified	1.80990123052691	0.0351555526453581	no	280	0.0215776183141038	158	NA	FT	OXIDATION-REDUCTION PROCESS	MITOCHONDRION		Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; located in the mitochondrial outer membrane and also in lipid particles; has similarity to ALDH3A2, a human fatty aldehyde dehydrogenase (FALDH) mutated in Sjogren-Larsson syndrome, a neurocutaneous disorder	cellular aldehyde metabolic process	3-chloroallyl aldehyde dehydrogenase activity	mitochondrial outer membrane|endosome|mitochondrion|lipid particle|integral to mitochondrial outer membrane
YOR140W	YOR140W	SFL1	hom	Verified	1.80967180711048	0.0351733485281419	no	281	0.033307037656389	195	NA	FT	TRANSCRIPTION FROM RNA POL II|GENE SILENCING	NUCLEUS		Transcriptional repressor and activator; involved in repression of flocculation-related genes, and activation of stress responsive genes; negatively regulated by cAMP-dependent protein kinase A subunit Tpk2p	gene silencing|Unknown|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II repressing transcription factor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity	nucleus
YGL209W	YGL209W	MIG2	hom	Verified	1.80418124240986	0.0356014494506152	no	282	0.0291902025169819	158	NA	FT	TRANSCRIPTION FROM RNA POL II|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS	NUCLEUS|MITOCHONDRION		Zinc finger transcriptional repressor; cooperates with Mig1p in glucose-induced repression of many genes; under low glucose conditions Mig2p relocalizes to mitochondrion, where it interacts with Ups1p and antagonizes mitochondrial fission factor, Dnm1p, indicative of a role in mitochondrial fusion or regulating morphology; regulates filamentous growth along with Mig2p in response to glucose depletion; MIG2 has a paralog, MIG3, that arose from the whole genome duplication	negative regulation of transcription from RNA polymerase II promoter by glucose|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding	mitochondrion|nucleus
YGR028W	YGR028W	MSP1	hom	Verified	1.80216837887415	0.0357594590489045	no	283	0.0253259787279529	134	NA	FT	PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial protein involved in sorting of proteins in the mitochondria; putative membrane-spanning ATPase	protein targeting to mitochondrion	ATPase activity	mitochondrial outer membrane|mitochondrion
YAL067W-A_p	YAL067W-A	YAL067W-A	hom	Uncharacterized	1.80034299148412	0.0359032482389207	no	284	0.0315050427233984	179	NA					Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching	biological_process	molecular_function	cellular_component
YLR080W	YLR080W	EMP46	hom	Verified	1.79729292360141	0.0361445645186727	no	285	0.0253058058474207	104	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport	ER to Golgi vesicle-mediated transport	glycoprotein binding	ER to Golgi transport vesicle|Golgi membrane
YPL038W-A_p	YPL038W-A	YPL038W-A	hom	Uncharacterized	1.79560628977212	0.0362785774289587	no	286	0.0228390971319801	143	NA					Putative protein of unknown function; identified by fungal homology and RT-PCR	biological_process	molecular_function	cellular_component
YPR111W	YPR111W	DBF20	hom	Verified	1.79554528314419	0.0362834323739806	no	287	0.0220645544941391	146	NA	FT	CELL CYCLE|CELL DIVISION|PROTEIN PHOSPHORYLATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Ser/Thr kinase involved in late nuclear division, one of the mitotic exit network (MEN) proteins; necessary for the execution of cytokinesis; also plays a role in regulating the stability of SWI5 and CLB2 mRNAs	cytokinesis after mitosis|protein phosphorylation|barrier septum assembly involved in cell cycle cytokinesis|regulation of mRNA catabolic process|exit from mitosis	protein serine/threonine kinase activity	spindle pole body|cellular bud neck|cytoplasm
YPL120W	YPL120W	VPS30	hom	Verified	1.79529468790179	0.0363033804773143	no	288	0.0428118469262676	254	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|MEMBRANE ORGANIZATION|PROTEOLYSIS|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS|PEROXISOME ORGANIZATION			Subunit of phosphatidylinositol (PtdIns) 3-kinase complexes I and II; Complex I is essential in autophagy and Complex II is required for vacuolar protein sorting; required for overflow degradation of misfolded proteins when ERAD is saturated; ortholog of the higher eukaryotic gene Beclin 1	phosphatidylinositol biosynthetic process|piecemeal microautophagy of nucleus|ER-associated protein catabolic process|peroxisome degradation|retrograde transport, endosome to Golgi|macroautophagy|CVT pathway|late endosome to vacuole transport	1-phosphatidylinositol-3-kinase activity	phosphatidylinositol 3-kinase complex I|phosphatidylinositol 3-kinase complex II|extrinsic to membrane|cytoplasm
YJL199C_d	YJL199C	MBB1	hom	Dubious	1.79061522211649	0.0366775313002724	no	289	0.0341048172599019	155	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; protein detected in large-scale protein-protein interaction studies	Unknown	Unknown	Unknown
YKL206C	YKL206C	ADD66	hom	Verified	1.78592703172229	0.0370555367495058	no	290	0.0331797101172957	180	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS			Protein involved in 20S proteasome assembly; forms a heterodimer with Pba1p that binds to proteasome precursors; similar to human PAC2 constituent of the PAC1-PAC2 complex involved in proteasome assembly	proteasome assembly	molecular_function	cytosol|cytoplasm
YBR212W	YBR212W	NGR1	hom	Verified	1.78571565345264	0.0370726547712662	no	291	0.0455755699105996	188	NA	FT	MITOCHONDRION ORGANIZATION			RNA binding protein that negatively regulates growth rate; interacts with the 3' UTR of the mitochondrial porin (POR1) mRNA and enhances its degradation; overexpression impairs mitochondrial function; interacts with Dhh1p to mediate POR1 mRNA decay; expressed in stationary phase	3'-UTR-mediated mRNA destabilization|mitochondrion organization	mRNA binding	cytoplasmic mRNA processing body|cytoplasmic stress granule|perinuclear region of cytoplasm|cytoplasm
YJL149W	YJL149W	DAS1	hom	Verified	1.78395662071218	0.0372153571349185	no	292	0.0460993049534248	267	NA	FT	PROTEOLYSIS		UBIQUITIN LIGASE COMPLEX	Putative SCF ubiquitin ligase F-box protein; interacts physically with both Cdc53p and Skp1 and genetically with CDC34; similar to putative F-box protein YDR131C	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	ubiquitin-protein ligase activity|protein binding, bridging	SCF ubiquitin ligase complex
YMR001C-A_p	YMR001C-A	YMR001C-A	hom	Uncharacterized	1.77876384437524	0.0376392435550429	no	293	0.0311256378939557	258	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YCL012C	YCL012C	YCL012C	hom	Verified	1.7645330993984	0.0388211338749023	no	294	0.0300745508014406	148	NA					Putative protein of unknown function; orthologs are present in S. bayanus, S. paradoxus and Ashbya gossypii; YCL012C is not an essential gene	biological_process	molecular_function	cellular_component
YHR007C-A_p	YHR007C-A	YHR007C-A	hom	Uncharacterized	1.76433122181786	0.038838115171232	no	295	0.0237188754427702	148	NA					Putative protein of unknown function; identified by expression profiling and mass spectrometry	biological_process	molecular_function	cellular_component
YOR065W	YOR065W	CYT1	hom	Verified	1.7637017340694	0.0388911045146309	no	296	0.0294200120607215	148	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex	oxidative phosphorylation|mitochondrial electron transport, ubiquinol to cytochrome c	electron transporter, transferring electrons within CoQH2-cytochrome c reductase complex activity	mitochondrion|mitochondrial respiratory chain|integral to membrane|mitochondrial inner membrane|mitochondrial respiratory chain complex III
YFL063W_d	YFL063W	YFL063W	hom	Dubious	1.76343449200833	0.0389136183510433	no	297	0.0190655169264693	97	NA					Dubious open reading frame, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YML118W	YML118W	NGL3	hom	Verified	1.76084570140608	0.0391322611386137	no	298	0.0254889818375942	148	NA					3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication	polyadenylation-dependent RNA catabolic process	poly(A)-specific ribonuclease activity|endonuclease activity	cellular_component
YPL226W	YPL226W	NEW1	hom	Verified	1.75899724291277	0.0392889884296385	no	299	0.0370280684202894	255	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|NUCLEOTIDE METABOLISM|RNA LOCALIZATION	NUCLEUS|MITOCHONDRION		ATP binding cassette protein that cosediments with polysomes and is required for biogenesis of the small ribosomal subunit; Asn/Gln-rich rich region supports [NU+] prion formation and susceptibility to [PSI+] prion induction	ribosomal small subunit biogenesis|poly(A)+ mRNA export from nucleus	ATPase activity|ATP binding	mitochondrion|polysome|cytoplasm
YPL015C	YPL015C	HST2	hom	Verified	1.75812883461378	0.0393627952796951	no	300	0.053939494303504	213	NA	FT	GENE SILENCING	NUCLEUS		Cytoplasmic member of the silencing information regulator 2 (Sir2) family of NAD(+)-dependent protein deacetylases; modulates nucleolar (rDNA) and telomeric silencing; possesses NAD(+)-dependent histone deacetylase activity in vitro; contains a nuclear export signal (NES); function regulated by its nuclear export	negative regulation of chromatin silencing at telomere|chronological cell aging|chromatin silencing at rDNA|negative regulation of mitotic recombination	NAD-dependent histone deacetylase activity	cytoplasm
YML108W	YML108W	YML108W	hom	Verified	1.75309646506528	0.0397927251104712	no	301	0.0269868812429331	114	NA	FT		NUCLEUS		Protein of unknown function; structure defines a new subfamily of the split beta-alpha-beta sandwiches; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YML108W is not an essential gene; relative distribution to the nucleus increases upon DNA replication stress	biological_process	molecular_function	nucleus|cytoplasm
YPL259C	YPL259C	APM1	hom	Verified	1.7512565867592	0.0399508610721926	no	302	0.0616764054006868	302	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Mu1-like medium subunit of the clathrin-associated protein complex (AP-1); binds clathrin; involved in clathrin-dependent Golgi protein sorting	Golgi to vacuole transport|vesicle-mediated transport	clathrin binding	AP-1 adaptor complex
YNL141W	YNL141W	AAH1	hom	Verified	1.75092215171163	0.0399796602595488	no	303	0.0387399107037483	206	NA	FT	NUCLEOTIDE METABOLISM	NUCLEUS		Adenine deaminase (adenine aminohydrolase), converts adenine to hypoxanthine; involved in purine salvage; transcriptionally regulated by nutrient levels and growth phase; Aah1p degraded upon entry into quiescence via SCF and the proteasome	adenine catabolic process|hypoxanthine salvage|purine-containing compound salvage	adenine deaminase activity	nucleus|cytoplasm
YAR028W_p	YAR028W	YAR028W	hom	Uncharacterized	1.75034013749776	0.0400298194453216	no	304	0.0507537206755744	224	NA					Putative integral membrane protein, member of DUP240 gene family; GFP-fusion protein is induced in response to the DNA-damaging agent MMS	biological_process	molecular_function	cellular_component
YBR177C	YBR177C	EHT1	hom	Verified	1.74788702146999	0.0402417963163287	no	305	0.0357701968295285	187	NA	FT	KETONE METABOLISM|LIPID METABOLISM	MITOCHONDRION		Acyl-coenzymeA:ethanol O-acyltransferase; plays a minor role in medium-chain fatty acid ethyl ester biosynthesis; possesses short-chain esterase activity; localizes to lipid particles and the mitochondrial outer membrane; EHT1 has a paralog, EEB1, that arose from the whole genome duplication	medium-chain fatty acid catabolic process|medium-chain fatty acid biosynthetic process|cellular lipid metabolic process	short-chain carboxylesterase activity|alcohol O-butanoyltransferase activity|serine hydrolase activity	mitochondrial outer membrane|mitochondrion|lipid particle
YNL130C-A_p	YNL130C-A	DGR1	hom	Uncharacterized	1.74780456304249	0.0402489374623301	no	306	0.0298151422645165	194	NA	FT		MITOCHONDRION		Protein of unknown function; dgr1 null mutant is resistant to 2-deoxy-D-glucose	biological_process	molecular_function	cellular_component
YBR233W	YBR233W	PBP2	hom	Verified	1.74740269409292	0.0402837552466077	no	307	0.0423750624981573	178	NA	FT		NUCLEUS		RNA binding protein; has similarity to mammalian heterogeneous nuclear RNP K protein, involved in the regulation of telomere position effect and telomere length; relative distribution to the nucleus increases upon DNA replication stress	telomere maintenance via telomere shortening	mRNA binding	cytoplasm
YKL162C_p	YKL162C	YKL162C	hom	Uncharacterized	1.74390941759198	0.0405874430998602	no	308	0.0225500126524571	117	NA	FT		MITOCHONDRION		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion	biological_process	molecular_function	mitochondrion
YGR207C	YGR207C	CIR1	hom	Verified	1.74357822853292	0.0406163311957583	no	309	0.0215531910882185	97	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Mitochondrial protein that interacts with frataxin (Yfh1p); putative ortholog of mammalian electron transfer flavoprotein complex subunit ETF-beta; may have a role in oxidative stress response	biological_process	molecular_function	mitochondrion
YOR348C	YOR348C	PUT4	hom	Verified	1.74287198677182	0.0406779891496314	no	310	0.052744437018562	248	NA	FT		PLASMA MEMBRANE		Proline permease, required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells	neutral amino acid transport|proline transport|gamma-aminobutyric acid transport	neutral amino acid transmembrane transporter activity|L-proline transmembrane transporter activity	integral to membrane|plasma membrane
YOR221C	YOR221C	MCT1	hom	Verified	1.74169449390706	0.0407809582457814	no	311	0.0604608498070962	302	NA	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Predicted malonyl-CoA:ACP transferase, putative component of a type-II mitochondrial fatty acid synthase that produces intermediates for phospholipid remodeling	fatty acid metabolic process|aerobic respiration	[acyl-carrier-protein] S-malonyltransferase activity	mitochondrion
YFR036W	YFR036W	CDC26	hom	Verified	1.74123781920884	0.0408209502929909	no	312	0.067970835434974	379	NA	FF|FT	CELL CYCLE|CHROMATIN ORGANIZATION|CELL DIVISION|PROTEOLYSIS	NUCLEUS	UBIQUITIN LIGASE COMPLEX	Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition	chromatin assembly|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination	ubiquitin-protein ligase activity	anaphase-promoting complex
YNR019W	YNR019W	ARE2	hom	Verified	1.74076074579728	0.0408627626792201	no	313	0.0413538495696312	157	NA	FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Acyl-CoA:sterol acyltransferase; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the presence of oxygen; ARE2 has a paralog, ARE1, that arose from the whole genome duplication	ergosterol metabolic process	ergosterol O-acyltransferase activity	integral to membrane|endoplasmic reticulum
YOR034C-A_p	YOR034C-A	YOR034C-A	hom	Uncharacterized	1.7374775324539	0.0411514582041352	no	314	0.0614304363803742	286	NA					Putative protein of unknown function; identified by expression profiling and mass spectrometry	biological_process	molecular_function	cellular_component
YBR016W	YBR016W	YBR016W	hom	Verified	1.73724919860642	0.0411715971297603	no	315	0.0428468042099611	280	NA	FT		PLASMA MEMBRANE		Tail-anchored plasma membrane protein with a conserved CYSTM module; predicted to be palmitoylated; has similarity to hydrophilins, which are involved in the adaptive response to hyperosmotic conditions; YBR016W has a paralog, YDL012C, that arose from the whole genome duplication	biological_process	molecular_function	cellular bud membrane|plasma membrane|mating projection membrane
YJL151C	YJL151C	SNA3	hom	Verified	1.73562884613668	0.0413147410309818	no	316	0.0343928086416358	170	NA	FT	VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM		Protein involved in efficient MVB sorting of proteins to the vacuole; may function as an RSP5 adapter protein for MVB cargos; integral membrane protein localized to vacuolar intralumenal vesicles	cellular protein catabolic process|endosome transport via multivesicular body sorting pathway	ubiquitin protein ligase binding	fungal-type vacuole lumen|integral to membrane
YBR042C	YBR042C	CST26	hom	Verified	1.73476225751399	0.0413914619269345	no	317	0.0369074589777863	210	NA	FT	LIPID METABOLISM			Putative transferase involved in phospholipid biosynthesis; required for incorporation of stearic acid into phosphatidylinositol; affects chromosome stability when overexpressed; CST26 has a paralog, YDR018C, that arose from the whole genome duplication	phospholipid biosynthetic process	transferase activity, transferring acyl groups	lipid particle
YDR219C	YDR219C	MFB1	hom	Verified	1.73216746678913	0.0416218748373208	no	318	0.028392720357726	144	NA	FT	PROTEOLYSIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION	UBIQUITIN LIGASE COMPLEX	Mitochondria-associated F-box protein involved in maintenance of normal mitochondrial morphology; interacts with Skp1p through the F-box motif; preferentially localizes to the mother cell during budding	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|mitochondrion organization	molecular_function	extrinsic to mitochondrial outer membrane|SCF ubiquitin ligase complex
YMR204C	YMR204C	INP1	hom	Verified	1.73091843114694	0.0417331569075159	no	319	0.035423372640283	176	NA	FT	PEROXISOME ORGANIZATION			Peripheral membrane protein of peroxisomes involved in peroxisomal inheritance; recruitment to peroxisomes is mediated by interaction with Pex3p at the peroxisomal membrane	peroxisome inheritance	molecular_function	peroxisome|extrinsic to intraperoxisomal membrane
YBL068W	YBL068W	PRS4	hom	Verified	1.72865831622361	0.0419351329167018	no	320	0.0216505536981828	149	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM			5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; PRS4 has a paralog, PRS2, that arose from the whole genome duplication	fungal-type cell wall organization|5-phosphoribose 1-diphosphate biosynthetic process	ribose phosphate diphosphokinase activity	cytoplasm
YNL314W	YNL314W	DAL82	hom	Verified	1.72427921552524	0.0423287247876651	no	321	0.0375749407036586	235	NA	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain	allantoin catabolic process|nitrogen catabolite activation of transcription from RNA polymerase II promoter	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	nucleus
YLR352W_p	YLR352W	YLR352W	hom	Uncharacterized	1.7222502222203	0.0425121003309463	no	322	0.0354590115397962	178	NA					Putative protein of unknown function with similarity to F-box proteins; interacts with Skp1p and Cdc53p; YLR352W is not an essential gene	biological_process	molecular_function	SCF ubiquitin ligase complex
YIL059C_d	YIL059C	YIL059C	hom	Dubious	1.7214948708524	0.0425805310620708	no	323	0.0257134964698808	129	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YIL060W	Unknown	Unknown	Unknown
YHR204W	YHR204W	MNL1	hom	Verified	1.71926319421488	0.0427832292883644	no	324	0.0384990365736079	252	NA	FT	PROTEOLYSIS	ENDOPLASMIC RETICULUM		Alpha-1,2-specific exomannosidase of the endoplasmic reticulum; in complex with Pdi1p, generates a Man7GlcNac2 oligosaccharide signal on glycoproteins destined for ubiquitin-proteasome degradation	ER-associated protein catabolic process	carbohydrate binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	endoplasmic reticulum lumen
YPL214C	YPL214C	THI6	hom	Verified	1.7164160799403	0.0430429577849346	no	325	0.0335577643108703	197	NA					Bifunctional enzyme with thiamine-phosphate pyrophosphorylase and 4-methyl-5-beta-hydroxyethylthiazole kinase activities, required for thiamine biosynthesis; GFP-fusion protein localizes to the cytoplasm in a punctate pattern	thiamine biosynthetic process	hydroxyethylthiazole kinase activity|thiamine-phosphate diphosphorylase activity	cytosol|cytoplasm
YFL040W_p	YFL040W	YFL040W	hom	Uncharacterized	1.71253064777238	0.0433994608101859	no	326	0.0345913457954327	169	NA					Putative transporter, member of the sugar porter family; YFL040W is not an essential gene	transmembrane transport	substrate-specific transmembrane transporter activity	integral to membrane|membrane
YKR052C	YKR052C	MRS4	hom	Verified	1.71220730265806	0.0434292360729374	no	327	0.03430641507395	212	NA	FT	RNA PROCESSING|ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Iron transporter of the mitochondrial carrier family; mediates Fe2+ transport across the inner mitochondrial membrane; active under low-iron conditions; may transport other cations; protein abundance increases in response to DNA replication stress; MRS4 has a paralog, MRS3, that arose from the whole genome duplication	mitochondrial iron ion transport|RNA splicing	iron ion transmembrane transporter activity	mitochondrion|integral to membrane|mitochondrial inner membrane
YDR005C	YDR005C	MAF1	hom	Verified	1.70687314544952	0.0439228166066506	no	328	0.0582758492963679	263	NA	FT		NUCLEUS		Highly conserved negative regulator of RNA polymerase III; binds to the N-terminal domain of the Rpc160p subunit of Pol III to prevent closed-complex formation; localization and activity are regulated by phosphorylation, mediated by TORC1, protein kinase A, and Sch9p; localizes to cytoplasm during vegetative growth and translocates to the nucleus and nucleolus under stress conditions	negative regulation of transcription from RNA polymerase III promoter	RNA polymerase III core binding	nucleolus|nucleus|cytoplasm
YLR250W	YLR250W	SSP120	hom	Verified	1.70676498032007	0.0439328719568081	no	329	0.0419173293899344	183	NA					Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern	biological_process	molecular_function	cytoplasm
YPL116W	YPL116W	HOS3	hom	Verified	1.70588678532406	0.0440145803051179	no	330	0.029057064434413	137	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION	NUCLEUS|SITE OF POLARIZED GROWTH		Trichostatin A-insensitive homodimeric histone deacetylase (HDAC) with specificity in vitro for histones H3, H4, H2A, and H2B; similar to Hda1p, Rpd3p, Hos1p, and Hos2p; deletion results in increased histone acetylation at rDNA repeats	regulation of transcription involved in G1/S phase of mitotic cell cycle|positive regulation of transcription from RNA polymerase II promoter|histone deacetylation	histone deacetylase activity	nucleus|cellular bud neck|cytoplasm
YCR069W	YCR069W	CPR4	hom	Verified	1.70495378294162	0.0441015222084341	no	331	0.0389546146229088	206	NA					Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; has a potential role in the secretory pathway	biological_process	peptidyl-prolyl cis-trans isomerase activity	membrane
YOR263C_d	YOR263C	YOR263C	hom	Dubious	1.70144169011216	0.0444300392013434	no	332	0.0465683733436445	206	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF DES3/YOR264W	Unknown	Unknown	Unknown
YKL093W	YKL093W	MBR1	hom	Verified	1.69790599971889	0.0447627523564182	no	333	0.0393584419025062	207	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Protein involved in mitochondrial functions and stress response; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants	aerobic respiration	molecular_function	cellular_component
YNR012W	YNR012W	URK1	hom	Verified	1.69612960466029	0.0449306691105053	no	334	0.0517889176626162	262	NA	FT	NUCLEOTIDE METABOLISM	NUCLEUS		Uridine/cytidine kinase, component of the pyrimidine ribonucleotide salvage pathway that converts uridine into UMP and cytidine into CMP; involved in the pyrimidine deoxyribonucleotide salvage pathway, converting deoxycytidine into dCMP	pyrimidine-containing compound salvage	uridine kinase activity	nucleus|cytoplasm
YML035C	YML035C	AMD1	hom	Verified	1.69597721074624	0.0449450979882312	no	335	0.0457843121501733	211	NA	FT	NUCLEOTIDE METABOLISM			AMP deaminase; tetrameric enzyme that catalyzes the deamination of AMP to form IMP and ammonia; thought to be involved in regulation of intracellular purine (adenine, guanine, and inosine) nucleotide pools	guanine salvage|purine nucleotide metabolic process	AMP deaminase activity	cytoplasm
YKL051W	YKL051W	SFK1	hom	Verified	1.69315765951401	0.045212730738092	no	336	0.0184246407959888	132	NA	FT	LIPID METABOLISM|SIGNALING|CYTOSKELETON ORGANIZATION	PLASMA MEMBRANE		Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane	vacuole organization|inositol lipid-mediated signaling|actin cytoskeleton organization	molecular_function	integral to membrane|plasma membrane
YCR005C	YCR005C	CIT2	hom	Verified	1.69299583824762	0.0452281296902021	no	337	0.0385195521604709	163	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Citrate synthase; catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate, peroxisomal isozyme involved in glyoxylate cycle; expression is controlled by Rtg1p and Rtg2p transcription factors; CIT2 has a paralog, CIT1, that arose from the whole genome duplication	glyoxylate cycle|glutamate biosynthetic process|citrate metabolic process	citrate (Si)-synthase activity	mitochondrion|peroxisome
YJL133W	YJL133W	MRS3	hom	Verified	1.69144035843246	0.0453763648526668	no	338	0.0386703553007023	187	NA	FT	RNA PROCESSING|ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Iron transporter, mediates Fe2+ transport across inner mito membrane; mitochondrial carrier family member; active under low-iron conditions; may transport other cations; MRS3 has a paralog, MRS4, that arose from the whole genome duplication	mitochondrial iron ion transport|RNA splicing	iron ion transmembrane transporter activity	mitochondrion|integral to membrane
YIL124W	YIL124W	AYR1	hom	Verified	1.68870708701391	0.0456377884168243	no	339	0.0453803316965863	235	NA	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS	ENDOPLASMIC RETICULUM|MITOCHONDRION		NADPH-dependent 1-acyl dihydroxyacetone phosphate reductase found in lipid particles, ER, and mitochondrial outer membrane; involved in phosphatidic acid biosynthesis; required for spore germination; capable of metabolizing steroid hormones	phosphatidic acid biosynthetic process	acylglycerone-phosphate reductase activity	mitochondrial outer membrane|mitochondrion|integral to membrane|endoplasmic reticulum|lipid particle|cytoplasm
YHL041W_d	YHL041W	YHL041W	hom	Dubious	1.68472463513408	0.0460208556230032	no	340	0.0289171658810031	176	NA					Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data	Unknown	Unknown	Unknown
YMR119W-A_d	YMR119W-A	YMR119W-A	hom	Dubious	1.68318880979078	0.0461692731936196	no	341	0.0456216231164073	206	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YMR182C	YMR182C	RGM1	hom	Verified	1.68316622762124	0.046171458331268	no	342	0.0431454026491183	197	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS|CHROMOSOME		Putative zinc finger DNA binding transcription factor; contains two N-terminal C2H2 zinc fingers and C-terminal proline rich domain; overproduction impairs cell growth and induces expression of genes involved in monosaccharide catabolism and aldehyde metabolism; regulates expression of of Y-prime telomeric elements and subtelomeric COS genes; RGM1 has a paralog, USV1, that arose from the whole genome duplication	positive regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity	nuclear chromatin
YMR102C_p	YMR102C	YMR102C	hom	Uncharacterized	1.68070310935284	0.0464102981779115	no	343	0.0400509568281782	239	NA					Protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; mutant shows increased resistance to azoles; YMR102C is not an essential gene	biological_process	molecular_function	cellular_component
YMR035W	YMR035W	IMP2	hom	Verified	1.67986557578292	0.0464917364332998	no	344	0.0291092828709578	186	NA	FT	PROTEIN LOCALIZATION|PROTEOLYSIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p	protein processing involved in protein targeting to mitochondrion	endopeptidase activity	mitochondrial inner membrane peptidase complex
YLL028W	YLL028W	TPO1	hom	Verified	1.67901519909779	0.046574540810478	no	345	0.0225657883829012	132	NA	FT		PLASMA MEMBRANE		Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; recognizes spermine, putrescine, and spermidine; catalyzes uptake of polyamines at alkaline pH and excretion at acidic pH; phosphorylation enhances activity and sorting to the plasma membrane	spermidine transport|putrescine transport|spermine transport	spermidine transmembrane transporter activity|spermine transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane|cellular bud membrane|plasma membrane
YOR350C	YOR350C	MNE1	hom	Verified	1.67871034922137	0.0466042539933051	no	346	0.0473006840442662	228	NA	FT	RNA PROCESSING	MITOCHONDRION		Mitochondrial matrix protein involved in splicing Group I aI5-beta intron from COX1 mRNA	Group I intron splicing	molecular_function	mitochondrion|ribonucleoprotein complex|mitochondrial matrix
YOR328W	YOR328W	PDR10	hom	Verified	1.67548647976878	0.0469194108007133	no	347	0.0393962677802489	196	NA	FT	NUCLEOTIDE METABOLISM	PLASMA MEMBRANE		ATP-binding cassette (ABC) transporter, multidrug transporter involved in the pleiotropic drug resistance network; regulated by Pdr1p and Pdr3p	drug transmembrane transport	ATPase activity, coupled to transmembrane movement of substances	integral to membrane|plasma membrane
YMR207C	YMR207C	HFA1	hom	Verified	1.67269310752256	0.0471938634010303	no	348	0.0409185458663811	212	NA	FT	KETONE METABOLISM|LIPID METABOLISM	MITOCHONDRION		Mitochondrial acetyl-coenzyme A carboxylase; catalyzes the production of malonyl-CoA in mitochondrial fatty acid biosynthesis; relocalizes from mitochondrion to cytoplasm upon DNA replication stress	fatty acid biosynthetic process	acetyl-CoA carboxylase activity	mitochondrion
YPR151C	YPR151C	SUE1	hom	Verified	1.66698032999262	0.0477591580975511	no	349	0.026631266782738	92	NA	FT	PROTEOLYSIS	MITOCHONDRION		Mitochondrial protein required for degradation of unstable forms of cytochrome c	protein catabolic process	molecular_function	mitochondrial envelope
YGL255W	YGL255W	ZRT1	hom	Verified	1.6662022166319	0.0478365723185011	no	350	0.0281241159393508	128	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		High-affinity zinc transporter of the plasma membrane, responsible for the majority of zinc uptake; transcription is induced under low-zinc conditions by the Zap1p transcription factor	high-affinity zinc ion transport	high affinity zinc uptake transmembrane transporter activity	integral to membrane|integral to plasma membrane
YBR065C	YBR065C	ECM2	hom	Verified	1.66515194571761	0.0479412226799174	no	351	0.0421762765177793	193	NA	FT	RNA PROCESSING	NUCLEUS		Pre-mRNA splicing factor, facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome, function may be regulated by Slu7p	mRNA splicing, via spliceosome	molecular_function	nucleus
YMR081C	YMR081C	ISF1	hom	Verified	1.66387907445504	0.0480682987785628	no	352	0.0373706193404467	217	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY			Serine-rich, hydrophilic protein with similarity to Mbr1p; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; expression is under glucose control; cotranscribed with NAM7 in a cyp1 mutant	aerobic respiration	molecular_function	cellular_component
YIL107C	YIL107C	PFK26	hom	Verified	1.66375177481517	0.0480810224513962	no	353	0.0568243516478905	255	NA	FT	CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY			6-phosphofructo-2-kinase, inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate; has negligible fructose-2,6-bisphosphatase activity; transcriptional regulation involves protein kinase A	regulation of glycolysis|fructose 2,6-bisphosphate metabolic process	6-phosphofructo-2-kinase activity	cytoplasm
YHL008C_p	YHL008C	YHL008C	hom	Uncharacterized	1.66267172713784	0.0481890823135924	no	354	0.0507119995126969	203	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Putative protein of unknown function, may be involved in the uptake of chloride ions; does not appear to be involved in monocarboxylic acid transport; green fluorescent protein (GFP)-fusion protein localizes to the vacuole	chloride transport|monocarboxylic acid transport	monocarboxylic acid transmembrane transporter activity|transporter activity	integral to membrane|fungal-type vacuole
YPL132W	YPL132W	COX11	hom	Verified	1.65820779475505	0.0486377660124009	no	355	0.0574891780904856	220	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION	RIBOSOME	Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p	protein complex assembly|aerobic respiration	copper ion binding	mitochondrial envelope|mitochondrion|mitochondrial ribosome|mitochondrial inner membrane
YHR079C	YHR079C	IRE1	hom	Verified	1.65692395041692	0.048767425737652	no	356	0.0654468449444928	299	NA	FF|FT	RNA PROCESSING|SIGNALING|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM		Serine-threonine kinase and endoribonuclease; transmembrane protein that mediates the unfolded protein response (UPR) by regulating Hac1p synthesis through HAC1 mRNA splicing; Kar2p binds inactive Ire1p and releases from it upon ER stress	endoplasmic reticulum unfolded protein response|fungal-type cell wall organization|inositol metabolic process|protein phosphorylation	unfolded protein binding|protein serine/threonine kinase activity|endoribonuclease activity|protein kinase activity|protein homodimerization activity	nucleus
YHR057C	YHR057C	CPR2	hom	Verified	1.65554987076034	0.0489065045401933	no	357	0.0473169297204016	194	NA					Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; has a potential role in the secretory pathway	biological_process	peptidyl-prolyl cis-trans isomerase activity	cellular_component
YJL168C	YJL168C	SET2	hom	Verified	1.64983824707987	0.049488011891367	no	358	0.0424445989690634	224	NA	FT	CELL CYCLE|CHROMATIN ORGANIZATION	NUCLEUS|CHROMOSOME		Histone methyltransferase with a role in transcriptional elongation; methylates H3 lysine 36, which suppresses incorporation of acetylated histones and signals for the deacetylation of these histones within transcribed genes; associates with the C-terminal domain of Rpo21p; histone methylation activity is regulated by phosphorylation status of Rpo21p	negative regulation of histone H3-K14 acetylation|DNA-dependent transcription, elongation|ascospore formation|regulation of transcription, DNA-dependent|histone deacetylation|regulation of DNA-dependent DNA replication initiation|histone methylation|negative regulation of antisense RNA transcription|Unknown|negative regulation of reciprocal meiotic recombination|positive regulation of histone acetylation	histone methyltransferase activity|histone methyltransferase activity (H3-K36 specific)	nucleus
YNL105W_d	YNL105W	RRT16	hom	Dubious	1.64864429628341	0.0496102641088316	no	359	0.0278194468659573	134	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene INP52; identified in a screen for mutants with decreased levels of rDNA transcription	Unknown	Unknown	Unknown
YIL102C_p	YIL102C	YIL102C	hom	Uncharacterized	1.64682444415425	0.0497970677382634	no	360	0.0419421363500709	191	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YER062C	YER062C	HOR2	hom	Verified	1.64384404485353	0.050104210381189	no	361	0.0359722660295468	128	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS		Glycerol-1-phosphatase involved in glycerol biosynthesis; induced in response to hyperosmotic or oxidative stress, and during diauxic shift; HOR2 has a paralog, RHR2, that arose from the whole genome duplication	cellular carbohydrate metabolic process|glycerol biosynthetic process|response to osmotic stress	glycerol-1-phosphatase activity	nucleus|cytoplasm
YLR360W	YLR360W	VPS38	hom	Verified	1.63670685705384	0.0508458677648889	no	362	0.0433929099600745	184	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEOLYSIS|VACUOLAR TRANSPORT	GOLGI APPARATUS		Part of a Vps34p phosphatidylinositol 3-kinase complex that functions in carboxypeptidase Y (CPY) sorting; binds Vps30p and Vps34p to promote production of phosphatidylinositol 3-phosphate (PtdIns3P) which stimulates kinase activity; required for overflow degradation of misfolded proteins when ERAD is saturated	ER-associated protein catabolic process|late endosome to vacuole transport	molecular_function	phosphatidylinositol 3-kinase complex II
YMR132C_p	YMR132C	JLP2	hom	Uncharacterized	1.63497753155435	0.0510268789019468	no	363	0.0282705916779875	131	NA					Protein of unknown function, contains sequence that closely resembles a J domain (typified by the E. coli DnaJ protein)	biological_process	molecular_function	cytoplasm
YNL078W	YNL078W	NIS1	hom	Verified	1.63258112160259	0.0512785621803326	no	364	0.0296663762180566	154	NA	FT	CELL CYCLE	NUCLEUS|SITE OF POLARIZED GROWTH		Protein localized in the bud neck at G2/M phase; physically interacts with septins; possibly involved in a mitotic signaling network	regulation of mitosis	molecular_function	nucleus|cellular bud neck
YDL146W	YDL146W	LDB17	hom	Verified	1.63040561378101	0.0515078994899456	no	365	0.0353367505040785	187	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Protein involved in the regulation of endocytosis; transiently recruited to actin cortical patches in a SLA1-dependent manner after late coat component assembly; GFP-fusion protein localizes to the periphery, cytoplasm, bud, and bud neck	endocytosis	molecular_function	cellular bud|cellular bud neck|cytoplasm|actin cortical patch
YCL074W	YCL074W	YCL074W	hom	pseudogene	1.62971118983072	0.0515812756403766	no	366	0.0474731178813851	165	NA	FT		NUCLEUS		Pseudogene: encodes fragment of Ty Pol protein	transposition, RNA-mediated	ribonuclease activity|peptidase activity|RNA binding|RNA-directed DNA polymerase activity|DNA-directed DNA polymerase activity	retrotransposon nucleocapsid
YDR073W	YDR073W	SNF11	hom	Verified	1.6281167882882	0.0517500622051477	no	367	0.038967012608044	192	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS	RSC COMPLEX	Subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; interacts with a highly conserved 40-residue sequence of Snf2p; relocates to the cytosol under hypoxic conditions	positive regulation of transcription from RNA polymerase II promoter	molecular_function	SWI/SNF complex
YFL020C	YFL020C	PAU5	hom	Verified	1.62563873664303	0.0520132648279817	no	368	0.037848704644048	193	NA					Member of the seripauperin multigene family encoded mainly in subtelomeric regions; induced during alcoholic fermentation; induced by low temperature and also by anaerobic conditions; negatively regulated by oxygen and repressed by heme	biological_process	molecular_function	integral to membrane|cytoplasm
YEL012W	YEL012W	UBC8	hom	Verified	1.62236120797281	0.0523630150358323	no	369	0.0513492517503505	250	NA	FT	KETONE METABOLISM|CARBOHYDRATE METABOLISM|PROTEOLYSIS			Ubiquitin-conjugating enzyme that negatively regulates gluconeogenesis by mediating the glucose-induced ubiquitination of fructose-1,6-bisphosphatase (FBPase); cytoplasmic enzyme that catalyzes the ubiquitination of histones in vitro	negative regulation of gluconeogenesis|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein polyubiquitination|protein monoubiquitination	ubiquitin-protein ligase activity	cytoplasm
YDR294C	YDR294C	DPL1	hom	Verified	1.62211327226447	0.0523895484303826	no	370	0.0376615102654213	151	NA	FT	KETONE METABOLISM|LIPID METABOLISM|SIGNALING|RESPONSE TO NUTRIENT LEVELS	ENDOPLASMIC RETICULUM		Dihydrosphingosine phosphate lyase, regulates intracellular levels of sphingolipid long-chain base phosphates (LCBPs), degrades phosphorylated long chain bases, prefers C16 dihydrosphingosine-l-phosphate as a substrate	calcium-mediated signaling|sphingolipid metabolic process|cellular response to starvation	sphinganine-1-phosphate aldolase activity	endoplasmic reticulum|cortical endoplasmic reticulum|perinuclear endoplasmic reticulum
YJR153W	YJR153W	PGU1	hom	Verified	1.62104078466805	0.0525044460653101	no	371	0.0423195468864035	168	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM			Endo-polygalacturonase, pectolytic enzyme that hydrolyzes the alpha-1,4-glycosidic bonds in the rhamnogalacturonan chains in pectins	pseudohyphal growth|pectin catabolic process	polygalacturonase activity	extracellular region
YBL095W_p	YBL095W	YBL095W	hom	Uncharacterized	1.61938871353558	0.0526818268497929	no	372	0.0518545927533231	258	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YOR333C_d	YOR333C	YOR333C	hom	Dubious	1.61835183631593	0.0527933977045264	no	373	0.0389770071097634	171	NA					Dubious open reading frame, unlikely to encode a functional protein; overlaps 5' end of MRS2 gene required for respiratory growth	Unknown	Unknown	Unknown
YML006C	YML006C	GIS4	hom	Verified	1.61727628369942	0.0529093281320808	no	374	0.0600241784061149	272	NA	FT	SIGNALING|ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		CAAX box containing protein of unknown function, proposed to be involved in the RAS/cAMP signaling pathway	cellular ion homeostasis|intracellular signal transduction	molecular_function	plasma membrane
YOR195W	YOR195W	SLK19	hom	Verified	1.61372744297189	0.0532932793277395	no	375	0.0282228849619822	163	NA	FT	CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME|CYTOSKELETON	KINETOCHORE	Kinetochore-associated protein required for normal segregation of chromosomes in meiosis and mitosis; component of the FEAR regulatory network, which promotes Cdc14p release from the nucleolus during anaphase; potential Cdc28p substrate	meiosis|mitotic spindle organization in nucleus	molecular_function	spindle midzone|condensed nuclear chromosome kinetochore|kinetochore|spindle
YOL160W_d	YOL160W	YOL160W	hom	Dubious	1.61343581343451	0.0533249288459555	no	376	0.0292487250497173	117	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YPL253C	YPL253C	VIK1	hom	Verified	1.61313016149073	0.0533581161531751	no	377	0.0557704825588238	292	NA	FT	CELL CYCLE|CHROMOSOME SEGREGATION	NUCLEUS|CYTOSKELETON		Protein that forms a complex with Kar3p at the spindle pole body, possible regulator of Kar3p function in microtubule-mediated processes; required for sister chromatid cohesion; has similarity to Cik1p	microtubule-based process|mitotic sister chromatid cohesion	microtubule motor activity	kinesin complex|spindle pole body
YDL237W	YDL237W	AIM6	hom	Verified	1.61221013723074	0.0534581100404811	no	378	0.0560865899978403	213	NA					Putative protein of unknown function, required for respiratory growth; YDL237W is not an essential gene	biological_process	molecular_function	cellular_component
YMR070W	YMR070W	MOT3	hom	Verified	1.60961725264338	0.053740719720356	no	379	0.0777604835825193	347	NA	FT	TRANSCRIPTION FROM RNA POL II|LIPID METABOLISM	NUCLEUS		Transcriptional repressor and activator with two C2-H2 zinc fingers; involved in repression of a subset of hypoxic genes by Rox1p, repression of several DAN/TIR genes during aerobic growth, and repression of ergosterol biosynthetic genes in response to hyperosmotic stress; contributes to recruitment of the Tup1p-Cyc8p general repressor to promoters; involved in positive transcriptional regulation of CWP2 and other genes; can form the [MOT3+] prion	cellular hyperosmotic response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of ergosterol biosynthetic process|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II repressing transcription factor binding|RNA polymerase II activating transcription factor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding	nucleus
YER175W-A_p	YER175W-A	YER175W-A	hom	Uncharacterized	1.60927864928029	0.053777712750594	no	380	0.0484624539622439	230	NA					Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching	biological_process	molecular_function	cellular_component
YML100W-A_p	YML100W-A	YML100W-A	hom	Uncharacterized	1.60667431748566	0.0540629151614851	no	381	0.0345632177406737	143	NA					Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching	biological_process	molecular_function	cellular_component
YJR080C	YJR080C	AIM24	hom	Verified	1.60568536904461	0.05417152878915	no	382	0.0375756989113368	197	NA	FT		MITOCHONDRION		Protein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays reduced respiratory growth and elevated frequency of mitochondrial genome loss	biological_process	molecular_function	mitochondrion
YHL027W	YHL027W	RIM101	hom	Verified	1.60254174994002	0.054517931483558	no	383	0.0964417803322017	447	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|ION HOMEOSTASIS|CELL WALL ORG/BIOGENESIS|CELL DIVISION|ION HOMEOSTASIS	NUCLEUS		Cys2His2 zinc-finger transcriptional repressor; involved in alkaline responsive gene repression as part of adaptation to a alkaline conditions; involved in cell wall assembly; required for alkaline pH-stimulated haploid invasive growth and sporulation; activated by alkaline-dependent proteolytic processing which results in removal of the C-terminal tail; similar to A. nidulans PacC	meiosis|negative regulation of transcription from RNA polymerase II promoter|fungal-type cell wall biogenesis|cellular response to anoxia|response to pH|ascospore formation|barrier septum assembly|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|sequence-specific DNA binding	nucleus
YEL009C	YEL009C	GCN4	hom	Verified	1.60133901935988	0.0546509255876955	no	384	0.164999594329235	683	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|PROTEIN COMPLEX ORG/BIOGENESIS|AMINO ACID METABOLISM|RIBOSOME BIOGENESIS|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Basic leucine zipper (bZIP) transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels	nitrogen catabolite activation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|positive regulation of RNA polymerase II transcriptional preinitiation complex assembly|positive regulation of transcription initiation from RNA polymerase II promoter|negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter in response to nutrient levels	chromatin binding|TFIID-class binding transcription factor activity|sequence-specific DNA binding|RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II transcription factor recruiting transcription factor activity|RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription|sequence-specific DNA binding transcription factor activity	nucleus
YLR389C	YLR389C	STE23	hom	Verified	1.60080472189626	0.0547100887239645	no	385	0.0390863411980738	241	NA	FT	PROTEOLYSIS			Metalloprotease involved, with homolog Axl1p, in N-terminal processing of pro-a-factor to the mature form; expressed in both haploids and diploids; member of the insulin-degrading enzyme family	peptide pheromone maturation	metallopeptidase activity|metalloendopeptidase activity	extrinsic to membrane
YNR065C_p	YNR065C	YNR065C	hom	Uncharacterized	1.59999973475571	0.054799321120682	no	386	0.0534544008276435	272	NA					Protein of unknown function; protein-protein interactions suggest a possible role in actin patch formation; YNR065C is not an essential gene	biological_process	molecular_function	integral to membrane
YCL049C_p	YCL049C	YCL049C	hom	Uncharacterized	1.59989355921334	0.0548110992058473	no	387	0.0530567880753254	259	NA					Protein of unknown function; localizes to membrane fraction; YCL049C is not an essential gene	biological_process	molecular_function	membrane
YAL008W	YAL008W	FUN14	hom	Verified	1.59875287249216	0.0549377621941484	no	388	0.0702487853218209	274	NA	FT		MITOCHONDRION		Mitochondrial protein of unknown function	biological_process	molecular_function	mitochondrial outer membrane|mitochondrion
YML129C	YML129C	COX14	hom	Verified	1.59868855588295	0.0549449108576185	no	389	0.0629028288541937	259	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial membrane protein, involved in translational regulation of Cox1p and assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes	mitochondrial respiratory chain complex IV assembly|negative regulation of mitochondrial translation	molecular_function	mitochondrial envelope|mitochondrion|integral to membrane|mitochondrial inner membrane|mitochondrial matrix|extrinsic to membrane
YJL144W	YJL144W	YJL144W	hom	Verified	1.5927923430328	0.0556033917143831	no	390	0.0472687510215028	199	NA					Cytoplasmic hydrophilin essential in dessication-rehydration process; expression induced by osmotic stress, starvation and during stationary phase; protein abundance increases in response to DNA replication stress	cellular response to water deprivation	molecular_function	cytoplasm
YKL063C_p	YKL063C	YKL063C	hom	Uncharacterized	1.59208378588318	0.0556829398822314	no	391	0.0359999583381912	191	NA	FT		GOLGI APPARATUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi	biological_process	molecular_function	Golgi apparatus
YMR195W	YMR195W	ICY1	hom	Verified	1.59189697257911	0.055703927959543	no	392	0.046866540464925	206	NA					Protein of unknown function, required for viability in rich media of cells lacking mitochondrial DNA; mutants have an invasive growth defect with elongated morphology; induced by amino acid starvation	biological_process	molecular_function	fungal-type vacuole membrane
YDL234C	YDL234C	GYP7	hom	Verified	1.59092728411511	0.0558129707190652	no	393	0.0333071273328059	128	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING|NUCLEOTIDE METABOLISM			GTPase-activating protein for yeast Rab family members including: Ypt7p (most effective), Ypt1p, Ypt31p, and Ypt32p (in vitro); involved in vesicle mediated protein trafficking	regulation of vacuole fusion, non-autophagic|vesicle-mediated transport	Rab GTPase activator activity	cytoplasm
YLL025W	YLL025W	PAU17	hom	Verified	1.58990065674464	0.0559285998065397	no	394	0.0354244340024516	172	NA					Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions; YLL025W is not an essential gene	biological_process	molecular_function	cellular_component
YOL044W	YOL044W	PEX15	hom	Verified	1.5889057614401	0.0560408351288624	no	395	0.0434951687451366	221	NA	FT	PROTEIN LOCALIZATION|SIGNALING|PEROXISOME ORGANIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Phosphorylated tail-anchored type II integral peroxisomal membrane protein required for peroxisome biogenesis, cells lacking Pex15p mislocalize peroxisomal matrix proteins to cytosol, overexpression results in impaired peroxisome assembly	protein import into peroxisome matrix, receptor recycling	protein anchor	integral to peroxisomal membrane
YJR082C	YJR082C	EAF6	hom	Verified	1.58554525407317	0.0564212517482908	no	396	0.0409056406343136	222	NA	FT	CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE	NUCLEUS	HISTONE ACETYLTRANSFERASE	Subunit of the NuA4 acetyltransferase complex that acetylates histone H4 and NuA3 acetyltransferase complex that acetylates histone H3	DNA repair|histone acetylation	histone acetyltransferase activity	nucleus|NuA4 histone acetyltransferase complex|NuA3 histone acetyltransferase complex
YMR124W_p	YMR124W	YMR124W	hom	Uncharacterized	1.58465185941543	0.0565227276378532	no	397	0.0450462825455914	236	NA					Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene; predicted to have a role in organelle organization	biological_process	molecular_function	cytoplasm
YPL061W	YPL061W	ALD6	hom	Verified	1.58403206520674	0.0565932111819616	no	398	0.0723377043261688	335	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM	MITOCHONDRION		Cytosolic aldehyde dehydrogenase, activated by Mg2+ and utilizes NADP+ as the preferred coenzyme; required for conversion of acetaldehyde to acetate; constitutively expressed; locates to the mitochondrial outer surface upon oxidative stress	response to salt stress|NADPH regeneration|acetate biosynthetic process	aldehyde dehydrogenase [NAD(P)+] activity	cytosol|mitochondrion
YCL075W	YCL075W	YCL075W	hom	pseudogene	1.58384830875017	0.056614121432314	no	399	0.0411199258373052	207	NA	FT		NUCLEUS		Pseudogene: encodes fragment of Ty Pol protein	transposition, RNA-mediated	ribonuclease activity|peptidase activity|RNA binding|RNA-directed DNA polymerase activity|DNA-directed DNA polymerase activity	retrotransposon nucleocapsid
YLR300W	YLR300W	EXG1	hom	Verified	1.58326858302011	0.0566801302229512	no	400	0.0443955355431214	236	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM			Major exo-1,3-beta-glucanase of the cell wall, involved in cell wall beta-glucan assembly; exists as three differentially glycosylated isoenzymes	fungal-type cell wall organization|cellular glucan metabolic process	glucan exo-1,3-beta-glucosidase activity	extracellular region|fungal-type cell wall
YGL154C	YGL154C	LYS5	hom	Verified	1.58173362066094	0.0568551970699476	no	401	0.0404818536564566	183	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Phosphopantetheinyl transferase involved in lysine biosynthesis; converts inactive apo-form of Lys2p (alpha-aminoadipate reductase) into catalytically active holo-form by posttranslational addition of phosphopantetheine	lysine biosynthetic process via aminoadipic acid|protein-cofactor linkage	holo-[acyl-carrier-protein] synthase activity	cytoplasm
YMR315W	YMR315W	YMR315W	hom	Verified	1.57699784101209	0.057398010926768	no	402	0.0601212142693652	279	NA	FT	OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM	NUCLEUS		Protein with NADP(H) oxidoreductase activity; transcription is regulated by Stb5p in response to NADPH depletion induced by diamide; promoter contains a putative Stb5p binding site; protein abundance increases in response to DNA replication stress	NADPH regeneration	oxidoreductase activity	nucleus|cytoplasm
YER069W	YER069W	ARG5,6	hom	Verified	1.57529275659607	0.0575944425788951	no	403	0.0443659729944831	158	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS	MITOCHONDRION		Acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase; N-acetyl-L-glutamate kinase (NAGK) catalyzes the 2nd and N-acetyl-gamma-glutamyl-phosphate reductase (NAGSA), the 3rd step in arginine biosynthesis; synthesized as a precursor which is processed in the mitochondrion to yield mature NAGK and NAGSA; enzymes form a metabolon complex with Arg2p; NAGK C-terminal domain stabilizes the enzymes, slows catalysis and is involved in feed-back inhibition by arginine	ornithine biosynthetic process|arginine biosynthetic process|regulation of transcription, DNA-dependent	N-acetyl-gamma-glutamyl-phosphate reductase activity|acetylglutamate kinase activity	mitochondrion|mitochondrial matrix
YNR055C	YNR055C	HOL1	hom	Verified	1.57528349670823	0.0575955107917912	no	404	0.0499355734330126	239	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION|PLASMA MEMBRANE		Putative transporter in the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; mutations in membrane-spanning domains permit cation and histidinol uptake	organic alcohol transport|cation transport	alcohol transmembrane transporter activity|inorganic cation transmembrane transporter activity	mitochondrion|integral to membrane|plasma membrane
YLR110C	YLR110C	CCW12	hom	Verified	1.5679613259692	0.0584450791110407	no	405	0.116172113990972	504	NA	FF|FT	CELL WALL ORG/BIOGENESIS	SITE OF POLARIZED GROWTH		Cell wall mannoprotein; plays a role in maintenance of newly synthesized areas of cell wall; localizes to periphery of small buds, septum region of larger buds, and shmoo tip; CCW12 has a paralog, YDR134C, that arose from the whole genome duplication	conjugation with cellular fusion|agglutination involved in conjugation with cellular fusion|fungal-type cell wall organization	molecular_function	fungal-type cell wall|mating projection tip|cellular bud tip
YIL132C	YIL132C	CSM2	hom	Verified	1.5654157794044	0.0587427254545833	no	406	0.0382775886288988	156	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION	NUCLEUS		Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function; structural analysis reveals a similar DNA-binding region in both Psy3p and Csm2p and that both regions work together to form a single DNA binding site; required for accurate chromosome segregation during meiosis	meiotic chromosome segregation|recombinational repair|maintenance of rDNA|error-free translesion synthesis	molecular_function	nucleus|Shu complex|cytoplasm
YOR019W	YOR019W	YOR019W	hom	Verified	1.56427371569303	0.0588766510223927	no	407	0.0496463166941469	214	NA	FT	CELL CYCLE			Protein of unknown function that may interact with ribosomes, based on co-purification experiments	mitochondrion degradation	molecular_function	ribosome
YJR039W_p	YJR039W	YJR039W	hom	Uncharacterized	1.56203134352148	0.0591403025983606	no	408	0.0370573659354209	189	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YGL034C_d	YGL034C	YGL034C	hom	Dubious	1.56079797294178	0.0592857129417051	no	409	0.0711023162342459	291	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YLR361C	YLR361C	DCR2	hom	Verified	1.55837934322673	0.0595716752034071	no	410	0.0441394863083285	187	NA	FT	CELL CYCLE|SIGNALING			Phosphoesterase involved in downregulation of the unfolded protein response, at least in part via dephosphorylation of Ire1p; dosage-dependent positive regulator of the G1/S phase transition through control of the timing of START	endoplasmic reticulum unfolded protein response|traversing start control point of mitotic cell cycle|protein dephosphorylation	hydrolase activity, acting on ester bonds|phosphoprotein phosphatase activity|phosphoric ester hydrolase activity	cellular_component
YLR216C	YLR216C	CPR6	hom	Verified	1.55758698353006	0.0596655931212751	no	411	0.0378882879705589	166	NA					Peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity; protein abundance increases in response to DNA replication stress	protein folding|protein refolding	unfolded protein binding|peptidyl-prolyl cis-trans isomerase activity	cytoplasm
YBR275C	YBR275C	RIF1	hom	Verified	1.5560661221457	0.0598461849328363	no	412	0.052871101400956	245	NA	FT	CELL CYCLE|GENE SILENCING	NUCLEUS|CHROMOSOME		Protein that binds to the Rap1p C-terminus and acts synergistically with Rif2p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation	telomere capping|telomere maintenance|chromatin silencing at silent mating-type cassette	telomeric DNA binding	nuclear telomere cap complex
YBR245C	YBR245C	ISW1	hom	Verified	1.54996431702711	0.0605750403984022	no	413	0.0533180104716246	266	NA	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS|CHROMOSOME		ATPase subunit of imitation-switch (ISWI) class chromatin remodelers; ATPase; forms a complex with Ioc3p (Isw1a), and a complex with Ioc2p and Ioc4p (Isw1b); Isw1a and Isw1b have partially overlapping and distinct roles, Isw1a involved in repression of transcription initiation and Isw1b involved in regulation of transcription elongation; Isw1b recruited to open reading frames by H3K36 methylation and acts with Chd1p to prevent trans-histone exchange over coding regions	termination of RNA polymerase I transcription|nucleosome positioning|termination of RNA polymerase II transcription|regulation of transcription by chromatin organization|DNA-dependent transcription, elongation|regulation of transcriptional start site selection at RNA polymerase II promoter|heterochromatin maintenance involved in chromatin silencing|chromatin remodeling|positive regulation of transcription from RNA polymerase II promoter	nucleosome binding|ATPase activity|rDNA binding|DNA binding	ISW1 complex|nucleolar chromatin
YAL054C	YAL054C	ACS1	hom	Verified	1.54845920934933	0.0607558876528073	no	414	0.0437667183130756	195	NA	FT	KETONE METABOLISM|CHROMATIN ORGANIZATION|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	NUCLEUS|ENDOPLASMIC RETICULUM|MITOCHONDRION		Acetyl-coA synthetase isoform which, along with Acs2p, is the nuclear source of acetyl-coA for histone acetylation; expressed during growth on nonfermentable carbon sources and under aerobic conditions	acetate fermentation|histone acetylation|acetyl-CoA biosynthetic process	acetate-CoA ligase activity|acid-ammonia (or amide) ligase activity	cytosol|mitochondrion|integral to membrane
YDL096C_d	YDL096C	OPI6	hom	Dubious	1.54829308092552	0.0607758747765153	no	415	0.0485900497967146	210	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene PMT1/YDL095W; YDL096C is not essential	Unknown	Unknown	Unknown
YDL082W	YDL082W	RPL13A	hom	Verified	1.54822572241031	0.060783980230826	no	416	0.0453418341224914	223	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L13A; not essential for viability; homologous to mammalian ribosomal protein L13, no bacterial homolog; RPL13A has a paralog, RPL13B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YER087C-A_d	YER087C-A	YER087C-A	hom	Dubious	1.54704971322886	0.0609256292398305	no	417	0.0527685174420361	201	NA					Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; overlaps the uncharacterized gene YER087W, a putative tRNA synthetase	Unknown	Unknown	Unknown
YJR106W	YJR106W	ECM27	hom	Verified	1.54417332893146	0.0612731741138897	no	418	0.0431161202385377	190	NA	FT	CELL WALL ORG/BIOGENESIS			Putative protein of unknown function; may play a role in cell wall biosynthesis, mutants are hypersensitive to Papulacandin B; null mutants have increased plasmid loss; displays a two-hybrid interaction with Pdr5p	fungal-type cell wall organization	molecular_function	integral to membrane
YOR104W	YOR104W	PIN2	hom	Verified	1.54311310069173	0.0614016683217973	no	419	0.0684655026232459	316	NA					Protein that induces appearance of [PIN+] prion when overproduced; predicted to be palmitoylated	biological_process	molecular_function	cellular_component
YJL198W	YJL198W	PHO90	hom	Verified	1.54218250764742	0.0615146247843922	no	420	0.066669753573449	271	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Low-affinity phosphate transporter; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth; PHO90 has a paralog, PHO87, that arose from the whole genome duplication	phosphate ion transport	phosphate ion transmembrane transporter activity	integral to membrane|membrane
YDR104C	YDR104C	SPO71	hom	Verified	1.53944914284578	0.0618473423065597	no	421	0.0373744362294415	203	NA	FT	CELL WALL ORG/BIOGENESIS			Meiosis-specific protein of unknown function, required for spore wall formation during sporulation, in particular for the proper size of the prospore membrane (PSM); interacts with SPO1; dispensable for both nuclear divisions during meiosis; contains two PH domains	ascospore wall assembly	molecular_function	ascospore wall
YJL214W	YJL214W	HXT8	hom	Verified	1.53905299795591	0.0618956791742027	no	422	0.061003085270394	266	NA	FT		PLASMA MEMBRANE		Protein of unknown function with similarity to hexose transporter family members, expression is induced by low levels of glucose and repressed by high levels of glucose	hexose transport	mannose transmembrane transporter activity|glucose transmembrane transporter activity|fructose transmembrane transporter activity	integral to membrane|plasma membrane
YOL113W	YOL113W	SKM1	hom	Verified	1.53533780806602	0.062350435836318	no	423	0.0726610398815522	327	NA	FT	CELL DIVISION|PROTEIN PHOSPHORYLATION	NUCLEUS|PLASMA MEMBRANE		Member of the PAK family of serine/threonine protein kinases with similarity to Ste20p and Cla4p; involved in down-regulation of sterol uptake; proposed to be a downstream effector of Cdc42p during polarized growth	negative regulation of gene expression|cytokinetic cell separation|protein phosphorylation|sterol import	protein serine/threonine kinase activity|protein kinase activity	plasma membrane|nucleus
YNR024W	YNR024W	MPP6	hom	Verified	1.5290956283234	0.0631203694823423	no	424	0.0615170058078061	260	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Nuclear exosome-associated RNA binding protein; involved in surveillance of pre-rRNAs and pre-mRNAs, and the degradation of cryptic non-coding RNAs (ncRNA); copurifies with ribosomes	nuclear mRNA surveillance of spliceosomal pre-mRNA splicing|nuclear mRNA surveillance of mRNA 3'-end processing|nuclear polyadenylation-dependent CUT catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	poly(U) RNA binding	ribosome|nucleus|nuclear exosome (RNase complex)|TRAMP complex
YBL083C_d	YBL083C	YBL083C	hom	Dubious	1.52845132518181	0.0632002599586424	no	425	0.065557153457231	317	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps verified ORF ALG3	Unknown	Unknown	Unknown
YGR033C	YGR033C	TIM21	hom	Verified	1.52808563555384	0.0632456387190359	no	426	0.0540166110844084	237	NA	FT	PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Nonessential subunit of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); interacts with the Translocase of the Outer Mitochondrial membrane (TOM complex) and with respiratory enzymes; may regulate TIM23 complex activity	protein import into mitochondrial matrix	molecular_function	mitochondrion|mitochondrial inner membrane presequence translocase complex
YBR244W	YBR244W	GPX2	hom	Verified	1.52764900772521	0.0632998534891483	no	427	0.0464642921937253	251	NA	FT	OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS	NUCLEUS|MITOCHONDRION		Phospholipid hydroperoxide glutathione peroxidase; protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress; induced by glucose starvation; protein abundance increases in response to DNA replication stress	cellular response to oxidative stress	phospholipid-hydroperoxide glutathione peroxidase activity|glutathione peroxidase activity	extrinsic to mitochondrial inner membrane|extrinsic to mitochondrial outer membrane|nucleus|cytoplasm
YOR071C	YOR071C	NRT1	hom	Verified	1.52736364923705	0.063335305143624	no	428	0.0542189948653605	252	NA	FT		PLASMA MEMBRANE		High-affinity nicotinamide riboside transporter; also transports thiamine with low affinity; shares sequence similarity with Thi7p and Thi72p; proposed to be involved in 5-fluorocytosine sensitivity	thiamine transport|nicotinamide riboside transport	nicotinamide riboside transporter activity	integral to membrane|plasma membrane
YAL022C	YAL022C	FUN26	hom	Verified	1.52685836547298	0.0633981172384118	no	429	0.0634406029947897	277	NA					Vacuolar membrane transporter with broad nucleoside selectivity; may regulate balance of nicotinamide riboside (NmR) levels between cytosol and vacuole, contributing to salvage of NmR for use in cytosolic NAD+ synthesis	nucleoside transport|nicotinamide riboside transport|transmembrane transport	nicotinamide riboside transporter activity|nucleoside transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane|intracellular|membrane
YDL174C	YDL174C	DLD1	hom	Verified	1.52549006615065	0.0635684547070739	no	430	0.0425584020165308	195	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane	cellular carbohydrate metabolic process|aerobic respiration	D-lactate dehydrogenase (cytochrome) activity	mitochondrion|mitochondrial inner membrane
YGR287C	YGR287C	IMA1	hom	Verified	1.52461474982684	0.0636776081275088	no	431	0.0622572167293696	295	NA	FT	CARBOHYDRATE METABOLISM	MITOCHONDRION		Major isomaltase (alpha-1,6-glucosidase/alpha-methylglucosidase); required for isomaltose utilization; specificity for isomaltose, alpha-methylglucoside, and palatinose; member of the IMA isomaltase family	disaccharide catabolic process	oligo-1,6-glucosidase activity	mitochondrion|ribosome
YOR297C	YOR297C	TIM18	hom	Verified	1.52437078004169	0.0637080575418707	no	432	0.038703651260078	184	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS	MITOCHONDRION		Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; may mediate assembly or stability of the complex	cellular response to oxidative stress|protein import into mitochondrial inner membrane|apoptotic process|response to acid|response to osmotic stress|response to arsenic-containing substance	protein channel activity	mitochondrion|integral to membrane|mitochondrial inner membrane protein insertion complex
YJR109C	YJR109C	CPA2	hom	Verified	1.52199641505598	0.0640049894797769	no	433	0.046505003083361	203	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Large subunit of carbamoyl phosphate synthetase, which catalyzes a step in the synthesis of citrulline, an arginine precursor	arginine biosynthetic process	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity	carbamoyl-phosphate synthase complex
YAL059W	YAL059W	ECM1	hom	Verified	1.52195171413915	0.0640105899633847	no	434	0.0486769718030477	219	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|CELL WALL ORG/BIOGENESIS	NUCLEUS		Pre-ribosomal factor involved in 60S ribosomal protein subunit export; associates with the pre-60S particle; shuttles between the nucleus and cytoplasm	fungal-type cell wall organization|ribosomal large subunit export from nucleus	molecular_function	nucleolus|nucleus|preribosome, large subunit precursor
YIL045W	YIL045W	PIG2	hom	Verified	1.521267197748	0.0640963991795176	no	435	0.0626349455245832	274	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY			Putative type-1 protein phosphatase targeting subunit that tethers Glc7p type-1 protein phosphatase to Gsy2p glycogen synthase	regulation of glycogen biosynthetic process	protein phosphatase type 1 regulator activity	cytoplasm
YDR131C_p	YDR131C	YDR131C	hom	Uncharacterized	1.51901570071018	0.0643792719875203	no	436	0.0375386692765055	174	NA	FT	PROTEOLYSIS			F-box protein, substrate-specific adaptor subunit that recruits substrates to a core ubiquitination complex	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	ubiquitin-protein ligase activity|protein binding, bridging	SCF ubiquitin ligase complex
YMR087W	YMR087W	YMR087W	hom	Verified	1.51753404050663	0.0645659528968326	no	437	0.0631972479046604	305	NA	FT	RNA PROCESSING			Putative ADP-ribose-1''-monophosphatase that converts ADP-ribose-1''-monophosphate to ADP-ribose; may have a role in tRNA splicing; contains an A1pp domain	tRNA splicing, via endonucleolytic cleavage and ligation	phosphatase activity	cellular_component
YOR202W	YOR202W	HIS3	hom	Verified	1.51600130765037	0.0647595108770904	no	438	0.0446741131516985	207	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p	histidine biosynthetic process	imidazoleglycerol-phosphate dehydratase activity	cellular_component
YIL052C	YIL052C	RPL34B	hom	Verified	1.51597612555057	0.0647626947042709	no	439	0.0996044575192793	446	NA	FF|FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L34B; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34B has a paralog, RPL34A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YMR032W	YMR032W	HOF1	hom	Verified	1.51544982932562	0.0648292632903855	no	440	0.0672904765854349	366	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CELL DIVISION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Bud neck-localized, SH3 domain-containing protein required for cytokinesis; is phosphorylated by Dbf2p; regulates actomyosin ring dynamics and septin localization; interacts with the formins, Bni1p and Bnr1p, and with Cyk3p, Vrp1p, and Bni5p	cytokinesis after mitosis|barrier septum assembly involved in cell cycle cytokinesis|response to DNA damage stimulus|cytokinesis	cytoskeletal protein binding	cellular bud neck contractile ring|cellular bud neck septin ring
YBR287W_p	YBR287W	YBR287W	hom	Uncharacterized	1.51459793842329	0.0649371273030055	no	441	0.0460134552280769	192	NA	FT		ENDOPLASMIC RETICULUM		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the ER; YBR287W is not an essential gene	biological_process	molecular_function	integral to membrane|endoplasmic reticulum
YBR141C_p	YBR141C	YBR141C	hom	Uncharacterized	1.51308264319491	0.0651293339244057	no	442	0.0565552376268674	256	NA	FT		NUCLEUS		Putative S-adenosylmethionine-dependent methyltransferase; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; YBR141C is not an essential gene	biological_process	S-adenosylmethionine-dependent methyltransferase activity	nucleolus
YKL074C	YKL074C	MUD2	hom	Verified	1.51197181347519	0.065270516615762	no	443	0.0501775162646948	251	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING	NUCLEUS		Protein involved in early pre-mRNA splicing; component of the pre-mRNA-U1 snRNP complex, the commitment complex; interacts with Msl5p/BBP splicing factor and Sub2p; similar to metazoan splicing factor U2AF65	mRNA branch site recognition	pre-mRNA branch point binding	commitment complex
YMR162C	YMR162C	DNF3	hom	Verified	1.51084976626205	0.0654133659418361	no	444	0.0535283851769926	223	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS	GOLGI APPARATUS		Aminophospholipid translocase (flippase) that maintains membrane lipid asymmetry in post-Golgi secretory vesicles; localizes to the trans-Golgi network; likely involved in protein transport; type 4 P-type ATPase	intracellular protein transport|phospholipid translocation	phospholipid-translocating ATPase activity	trans-Golgi network transport vesicle|integral to membrane
YLL021W	YLL021W	SPA2	hom	Verified	1.51035100342668	0.0654769419024869	no	445	0.0768575557468047	322	NA	FT	CELL CYCLE|SIGNALING|CELL DIVISION|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH		Component of the polarisome, which functions in actin cytoskeletal organization during polarized growth; acts as a scaffold for Mkk1p and Mpk1p cell wall integrity signaling components; potential Cdc28p substrate	regulation of initiation of mating projection growth|regulation of termination of mating projection growth|pseudohyphal growth|invasive filamentous growth|mating projection assembly	cytoskeletal regulatory protein binding	incipient cellular bud site|cellular bud neck|mating projection tip|cellular bud tip
YCL063W	YCL063W	VAC17	hom	Verified	1.50715633632615	0.0658852946421407	no	446	0.072185244048929	339	NA					Phosphoprotein involved in vacuole inheritance; degraded in late M phase of the cell cycle; acts as a vacuole-specific receptor for myosin Myo2p	vacuole inheritance	protein anchor	fungal-type vacuole membrane
YNR063W_p	YNR063W	YNR063W	hom	Uncharacterized	1.50402269108378	0.0662877621280706	no	447	0.0538702527731673	243	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Putative zinc-cluster protein of unknown function	biological_process	sequence-specific DNA binding	cellular_component
YDR323C	YDR323C	PEP7	hom	Verified	1.5017107956605	0.0665859072992652	no	448	0.131901452428554	547	NA	FF|FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT			Multivalent adaptor protein that facilitates vesicle-mediated vacuolar protein sorting by ensuring high-fidelity vesicle docking and fusion, which are essential for targeting of vesicles to the endosome; required for vacuole inheritance	Golgi to vacuole transport|vacuole inheritance|vesicle fusion|vesicle docking involved in exocytosis|Golgi to endosome transport	phosphatidylinositol-3-phosphate binding	external side of endosome membrane|cytoplasm
YML018C	YML018C	YML018C	hom	Verified	1.50169905778357	0.0665874236757249	no	449	0.0685794603477111	310	NA					Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the membrane of the vacuole; physical interaction with Atg27p suggests a possible role in autophagy; YML018C is not an essential gene; relative distribution to the vacuolar membrane decreases upon DNA replication stress; YML018C has a paralog, THI74, that arose from the whole genome duplication	biological_process	molecular_function	fungal-type vacuole membrane|integral to membrane
YBR223C	YBR223C	TDP1	hom	Verified	1.49342658319722	0.0676627793840305	no	450	0.0751037873334402	294	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		Tyrosyl-DNA phosphodiesterase I; hydrolyzes 3' and 5'-phosphotyrosyl bonds; involved in the repair of DNA lesions created by topoisomerase I and topoisomerase II; mutations in human homolog result in the neurodegenerative disease SCANI	DNA repair	3'-tyrosyl-DNA phosphodiesterase activity|5'-tyrosyl-DNA phosphodiesterase activity	nucleus
YPL121C	YPL121C	MEI5	hom	Verified	1.49264299594852	0.0677653311259096	no	451	0.0457474168719666	200	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Meiosis specific protein involved in DMC1-dependent meiotic recombination, forms heterodimer with Sae3p; proposed to be an assembly factor for Dmc1p	meiotic DNA recombinase assembly|reciprocal meiotic recombination	molecular_function	condensed nuclear chromosome
YFL010C	YFL010C	WWM1	hom	Verified	1.49223736663384	0.0678184648776515	no	452	0.0652671906870795	251	NA	FT		NUCLEUS|MITOCHONDRION		WW domain containing protein of unknown function; binds to Mca1p, a caspase-related protease that regulates H2O2-induced apoptosis; overexpression causes G1 phase growth arrest and clonal death that is suppressed by overexpression of MCA1	biological_process	molecular_function	mitochondrion|nucleus|cytoplasm
YMR104C	YMR104C	YPK2	hom	Verified	1.49115478282869	0.0679604310508022	no	453	0.0412685342405978	168	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL WALL ORG/BIOGENESIS|PROTEIN PHOSPHORYLATION	NUCLEUS		Protein kinase with similarity to serine/threonine protein kinase Ypk1p; functionally redundant with YPK1 at the genetic level; participates in a signaling pathway required for optimal cell wall integrity; homolog of mammalian kinase SGK; YPK2 has a paralog, YPK1, that arose from the whole genome duplication	eisosome assembly|protein phosphorylation	protein kinase activity	nucleus|cytoplasm
YOL053W	YOL053W	AIM39	hom	Verified	1.49111117369441	0.0679661546012341	no	454	0.0467767942058021	178	NA	FT		MITOCHONDRION		Putative protein of unknown function; null mutant displays elevated frequency of mitochondrial genome loss	biological_process	molecular_function	cellular_component
YDR411C	YDR411C	DFM1	hom	Verified	1.49107013131318	0.0679715416140417	no	455	0.0481663753619567	225	NA	FT	SIGNALING|PROTEOLYSIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	UBIQUITIN LIGASE COMPLEX	Endoplasmic reticulum (ER) localized protein involved in ER-associated protein degradation (ERAD), ER stress and homeostasis; interacts with components of ERAD-L and ERAD-C and Cdc48p; derlin-like family member similar to Der1p	endoplasmic reticulum unfolded protein response|ER-associated protein catabolic process	molecular_function	Doa10p ubiquitin ligase complex|integral to membrane|endoplasmic reticulum|Hrd1p ubiquitin ligase ERAD-L complex
YMR074C	YMR074C	YMR074C	hom	Verified	1.48861546070017	0.0682943289991234	no	456	0.0509541299852058	238	NA	FT		NUCLEUS		Protein with homology to human PDCD5; PDCD5 is involved in programmed cell death; N-terminal region forms a conserved triple-helix bundle structure; overexpression promotes H2O2-induced apoptosis; YMR074C is not an essential gene; protein abundance increases in response to DNA replication stress	apoptotic process	molecular_function	nucleus|cytoplasm
YOR377W	YOR377W	ATF1	hom	Verified	1.48707962224183	0.0684968914362631	no	457	0.0474092921673248	222	NA	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	ENDOMEMBRANE SYSTEM		Alcohol acetyltransferase; responsible for the major part of volatile acetate ester production during fermentation; main enzyme involved in terpenyl acetate synthesis; potential roles in lipid and sterol metabolism	Unknown|fermentation	alcohol O-acetyltransferase activity	lipid particle
YBL043W	YBL043W	ECM13	hom	Verified	1.48496836087285	0.0687761027501319	no	458	0.0409624289394038	138	NA	FT	CELL WALL ORG/BIOGENESIS			Non-essential protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation; ECM13 has a paralog, YJR115W, that arose from the whole genome duplication	fungal-type cell wall organization	molecular_function	cellular_component
YIL058W_d	YIL058W	YIL058W	hom	Dubious	1.48430318315425	0.0688642531153692	no	459	0.0732249493392535	265	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YMR071C	YMR071C	TVP18	hom	Verified	1.48293453136088	0.0690459028950146	no	460	0.100754056910521	408	NA	FF|FT	VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; may interact with ribosomes, based on co-purification experiments	vesicle-mediated transport	molecular_function	integral to membrane|integral to Golgi membrane|clathrin-coated vesicle
YDR009W	YDR009W	GAL3	hom	Verified	1.48225743576948	0.0691359045920327	no	461	0.0481331102886286	199	NA	FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Transcriptional regulator; involved in activation of the GAL genes in response to galactose; forms a complex with Gal80p to relieve Gal80p inhibition of Gal4p; binds galactose and ATP but does not have galactokinase activity; GAL3 has a paralog, GAL1, that arose from the whole genome duplication	maintenance of protein location|galactose metabolic process|positive regulation of transcription from RNA polymerase II promoter by galactose	protein binding	nucleus|cytoplasm
YJR140C	YJR140C	HIR3	hom	Verified	1.4775639114689	0.0697622699172632	no	462	0.0759219496119166	310	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION	NUCLEUS		Subunit of the HIR complex; a nucleosome assembly complex involved in regulation of histone gene transcription; involved in position-dependent gene silencing and nucleosome reassembly; ortholog of human CABIN1 protein	DNA replication-independent nucleosome assembly|regulation of transcription involved in G1/S phase of mitotic cell cycle|transcription elongation from RNA polymerase II promoter	nucleosome binding|DNA binding|transcription corepressor activity	HIR complex|nucleus
YGR258C	YGR258C	RAD2	hom	Verified	1.47715310835396	0.0698173000802231	no	463	0.0454665518148998	204	NA	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO DNA DAMAGE	NUCLEUS		Single-stranded DNA endonuclease, cleaves single-stranded DNA during nucleotide excision repair to excise damaged DNA; subunit of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPG protein	nucleotide-excision repair, DNA incision, 3'-to lesion|transcription from RNA polymerase II promoter	single-stranded DNA specific endodeoxyribonuclease activity	nucleotide-excision repair factor 3 complex
YDR273W	YDR273W	DON1	hom	Verified	1.47625364362052	0.069937906790323	no	464	0.0448143815901319	236	NA	FT	CELL CYCLE|CELL WALL ORG/BIOGENESIS|CELL DIVISION			Meiosis-specific component of the spindle pole body, part of the leading edge protein (LEP) coat, forms a ring-like structure at the leading edge of the prospore membrane during meiosis II	meiosis|ascospore wall assembly	molecular_function	prospore membrane
YOL115W	YOL115W	PAP2	hom	Verified	1.47535335714697	0.0700587841575074	no	465	0.0815985312636078	389	NA	FT	CELL CYCLE|RNA PROCESSING|RESPONSE TO DNA DAMAGE|CELL DIVISION	NUCLEUS		Non-canonical poly(A) polymerase, involved in nuclear RNA degradation as a component of the TRAMP complex; catalyzes polyadenylation of hypomodified tRNAs, and snoRNA and rRNA precursors; overlapping but non-redundant functions with Trf5p	polyadenylation-dependent mRNA catabolic process|nuclear polyadenylation-dependent CUT catabolic process|base-excision repair|nuclear polyadenylation-dependent tRNA catabolic process|nuclear polyadenylation-dependent snoRNA catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|nuclear polyadenylation-dependent snRNA catabolic process|ncRNA polyadenylation|histone mRNA catabolic process|nuclear polyadenylation-dependent mRNA catabolic process|nuclear polyadenylation-dependent antisense transcript catabolic process|U4 snRNA 3'-end processing|nuclear mRNA surveillance of mRNA 3'-end processing|polyadenylation-dependent snoRNA 3'-end processing|snoRNA polyadenylation|tRNA modification	5'-deoxyribose-5-phosphate lyase activity|polynucleotide adenylyltransferase activity	nucleolus|nucleus|TRAMP complex
YCR071C	YCR071C	IMG2	hom	Verified	1.47515733229177	0.0700851248178524	no	466	0.0831559975664296	344	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YGL133W	YGL133W	ITC1	hom	Verified	1.47309435016043	0.0703627983360201	no	467	0.0785397634894129	304	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS		Subunit of the ATP-dependent Isw2p-Itc1p chromatin remodeling complex, required for repression of a-specific genes, repression of early meiotic genes during mitotic growth, and repression of INO1; similar to mammalian Acf1p, the regulatory subunit of the mammalian ATP-utilizing chromatin assembly and modifying factor (ACF) complex	negative regulation of transcription from RNA polymerase II promoter by pheromones|chromatin remodeling|chromatin silencing at telomere	molecular_function	chromatin accessibility complex
YBR017C	YBR017C	KAP104	hom	Verified	1.47258365602243	0.0704316672548153	no	468	0.0617676422554361	305	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE	SITE OF POLARIZED GROWTH		Transportin or cytosolic karyopherin beta 2; functions in the rg-nuclear localization signal-mediated nuclear import/reimport of mRNA-binding proteins Nab2p and Hrp1p; regulates asymmetric protein synthesis in daughter cells during mitosis	protein import into nucleus|cell cycle|mRNA-binding (hnRNP) protein import into nucleus|transcription factor import into nucleus	nuclear localization sequence binding	cytosol|integral to membrane|cellular bud neck|cellular bud tip
YFR016C	YFR016C	YFR016C	hom	Verified	1.47191999580444	0.0705212416102519	no	469	0.0380790027382179	160	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and bud; interacts with Spa2p; YFL016C is not an essential gene	biological_process	molecular_function	cellular bud|cytoplasm
YMR089C	YMR089C	YTA12	hom	Verified	1.47148207126736	0.0705803963143666	no	470	0.0480218932512568	248	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Component, with Afg3p, of the mitochondrial inner membrane m-AAA protease that mediates degradation of misfolded or unassembled proteins and is also required for correct assembly of mitochondrial enzyme complexes	proteolysis|signal peptide processing|protein complex assembly|protein import into mitochondrial intermembrane space	metallopeptidase activity|protein binding|ATPase activity|ATP binding	mitochondrion|mitochondrial inner boundary membrane|mitochondrial inner membrane|m-AAA complex|cytoplasm
YIL155C	YIL155C	GUT2	hom	Verified	1.47144763299173	0.0705850498425015	no	471	0.0565433323154714	245	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM	MITOCHONDRION		Mitochondrial glycerol-3-phosphate dehydrogenase; expression is repressed by both glucose and cAMP and derepressed by non-fermentable carbon sources in a Snf1p, Rsf1p, Hap2/3/4/5 complex dependent manner	NADH oxidation|replicative cell aging|glycerol metabolic process	glycerol-3-phosphate dehydrogenase activity	mitochondrion|integral to mitochondrial outer membrane
YBR089C-A	YBR089C-A	NHP6B	hom	Verified	1.46736908166344	0.071137840265448	no	472	0.0505239020654882	233	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		High-mobility group (HMG) protein, binds to and remodels nucleosomes; involved in recruiting FACT and other chromatin remodelling complexes to the chromosomes; functionally redundant with Nhp6Ap; homologous to mammalian HMGB1 and HMGB2; NHP6B has a paralog, NHP6A, that arose from the whole genome duplication	RNA polymerase III transcriptional preinitiation complex assembly|chromatin remodeling|transcription from RNA polymerase II promoter	nucleosome binding|DNA binding, bending|sequence-specific DNA binding	nucleus
YCR015C_p	YCR015C	YCR015C	hom	Uncharacterized	1.46557760909923	0.0713816974650652	no	473	0.0587255981886746	267	NA					Putative protein of unknown function; YCR015C is not an essential gene	biological_process	molecular_function	cellular_component
YLR294C_d	YLR294C	YLR294C	hom	Dubious	1.4636357425483	0.0716467505743835	no	474	0.0739111730228561	311	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene ATP14	Unknown	Unknown	Unknown
YEL038W	YEL038W	UTR4	hom	Verified	1.46299074780602	0.071734955325145	no	475	0.042368044543973	209	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Protein with sequence similarity to 2,3-diketo-5-methylthiopentyl-1-phosphate enolase-phosphatases, involved in methionine salvage; found in both the cytoplasm and nucleus	L-methionine salvage from methylthioadenosine	acireductone synthase activity	nucleus|cytoplasm
YMR019W	YMR019W	STB4	hom	Verified	1.45878355965371	0.0723123444726136	no	476	0.0593826868416953	216	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Putative transcription factor; contains a Zn(II)2Cys6 zinc finger domain characteristic of DNA-binding proteins; computational analysis suggests a role in regulation of expression of genes encoding transporters; binds Sin3p in a two-hybrid assay;	biological_process	sequence-specific DNA binding|DNA binding	nucleus
YGR169C	YGR169C	PUS6	hom	Verified	1.45710388167664	0.072543853536707	no	477	0.0399450802758914	200	NA	FT	RNA PROCESSING	MITOCHONDRION		tRNA:pseudouridine synthase, catalyzes the conversion of uridine to pseudouridine at position 31 in cytoplasmic and mitochondrial tRNAs; mutation of Asp168 to Ala abolishes enzyme activity; not essential for viability	tRNA pseudouridine synthesis	pseudouridine synthase activity	mitochondrion|cytoplasm
YPR153W	YPR153W	YPR153W	hom	Verified	1.45683688934848	0.0725807051737627	no	478	0.0581087662864816	240	NA					Putative protein of unknown function	biological_process	molecular_function	integral to membrane
YMR114C	YMR114C	YMR114C	hom	Verified	1.45624827754065	0.0726619990126114	no	479	0.0656855200129148	246	NA	FT		NUCLEUS		Protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; YMR114C is not an essential gene	biological_process	molecular_function	ribosome|nucleus|cytoplasm
YKL107W_p	YKL107W	YKL107W	hom	Uncharacterized	1.45040825681822	0.0734723529770488	no	480	0.0559163301808867	239	NA	FT	OXIDATION-REDUCTION PROCESS			Putative short-chain dehydrogenase/reductase; proposed to be a palmitoylated membrane protein	biological_process	molecular_function	cellular_component
YKL092C	YKL092C	BUD2	hom	Verified	1.44831385678621	0.0737646470345905	no	481	0.0667677529875965	249	NA	FT	CELL CYCLE|SIGNALING|CELL DIVISION|NUCLEOTIDE METABOLISM	PLASMA MEMBRANE		GTPase activating factor for Rsr1p/Bud1p; required for both axial and bipolar budding patterns; mutants exhibit random budding in all cell types; mutant deficient in mitotic spindle position checkpoint	bipolar cellular bud site selection|small GTPase mediated signal transduction|filamentous growth|cellular bud site selection|axial cellular bud site selection	GTPase activator activity|Ras GTPase activator activity	intracellular
YJL088W	YJL088W	ARG3	hom	Verified	1.4440880526852	0.0743571041667724	no	482	0.0847764999654552	403	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Ornithine carbamoyltransferase (carbamoylphosphate:L-ornithine carbamoyltransferase), catalyzes the sixth step in the biosynthesis of the arginine precursor ornithine	arginine biosynthetic process|ornithine metabolic process	ornithine carbamoyltransferase activity	cytosol
YJR004C	YJR004C	SAG1	hom	Verified	1.44258973265651	0.0745680386896371	no	483	0.0737598036037935	280	NA					Alpha-agglutinin of alpha-cells, binds to Aga1p during agglutination, N-terminal half is homologous to the immunoglobulin superfamily and contains binding site for a-agglutinin, C-terminal half is highly glycosylated and contains GPI anchor	agglutination involved in conjugation with cellular fusion	cell adhesion molecule binding	fungal-type cell wall
YJL080C	YJL080C	SCP160	hom	Verified	1.44083740776858	0.0748153112689532	no	484	0.0670342560771783	342	NA	FT	CELL CYCLE|SIGNALING|RNA LOCALIZATION|CHROMOSOME SEGREGATION|GENE SILENCING	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM		Essential RNA-binding G protein effector of mating response pathway, mainly associated with nuclear envelope and ER, interacts in mRNA-dependent manner with translating ribosomes via multiple KH domains, similar to vertebrate vigilins	meiotic telomere clustering|pheromone-dependent signal transduction involved in conjugation with cellular fusion|chromosome segregation|intracellular mRNA localization|chromatin silencing at silent mating-type cassette|chromatin silencing at telomere	G-protein alpha-subunit binding|RNA binding	endoplasmic reticulum membrane|polysome|nuclear outer membrane-endoplasmic reticulum membrane network
YIR013C	YIR013C	GAT4	hom	Verified	1.43910263675307	0.0750607225430761	no	485	0.049409695522904	210	NA	FT		NUCLEUS		Protein containing GATA family zinc finger motifs	transcription, DNA-dependent	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	nucleus
YNR005C_d	YNR005C	YNR005C	hom	Dubious	1.43845854552136	0.075151995730669	no	486	0.09645510317111	407	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YLL032C	YLL032C	YLL032C	hom	Verified	1.43161479537091	0.0761270464986149	no	487	0.059076921750621	220	NA					Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene	biological_process	molecular_function	ribosome|cytoplasm
YNL291C	YNL291C	MID1	hom	Verified	1.43037900072944	0.0763041359444951	no	488	0.0540543662008551	223	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	ENDOPLASMIC RETICULUM|PLASMA MEMBRANE		N-glycosylated integral membrane protein of the ER membrane and plasma membrane, functions as a stretch-activated Ca2+-permeable cation channel required for Ca2+ influx stimulated by pheromone; interacts with Cch1p; forms an oligomer	calcium ion transport	stretch-activated, cation-selective, calcium channel activity|calcium channel activity	endoplasmic reticulum|plasma membrane
YDR146C	YDR146C	SWI5	hom	Verified	1.42980134165741	0.0763870219624491	no	489	0.0592102294859684	259	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE	NUCLEUS		Transcription factor that recruits Mediator and Swi/Snf complexes; activates transcription of genes expressed at the M/G1 phase boundary and in G1 phase; required for expression of the HO gene controlling mating type switching; localization to nucleus occurs during G1 and appears to be regulated by phosphorylation by Cdc28p kinase; SWI5 has a paralog, ACE2, that arose from the whole genome duplication	positive regulation of mating type switching|regulation of transcription involved in G1 phase of mitotic cell cycle|positive regulation of transcription on exit from mitosis, from RNA polymerase II promoter	RNA polymerase II distal enhancer sequence-specific DNA binding|sequence-specific DNA binding|sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity|mediator complex binding	nucleus|cytoplasm
YBR107C	YBR107C	IML3	hom	Verified	1.42971498686154	0.0763994185545717	no	490	0.0617406070362245	320	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME	KINETOCHORE	Outer kinetochore protein and component of the Ctf19 complex; involved in the establishment of pericentromeric cohesion during mitosis; prevents non-disjunction of sister chromatids during meiosis II; required for localization of Sgo1p to pericentric sites during meiosis I; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-L and fission yeast fta1	establishment of meiotic sister chromatid cohesion|ascospore formation|protein localization to chromosome, centromeric region|meiotic sister chromatid segregation|maintenance of meiotic sister chromatid cohesion|establishment of mitotic sister chromatid cohesion	molecular_function	condensed nuclear chromosome outer kinetochore
YBL081W_p	YBL081W	YBL081W	hom	Uncharacterized	1.42892646464189	0.0765126850275937	no	491	0.0581644414116187	218	NA					Non-essential protein of unknown function; null mutation results in a decrease in plasma membrane electron transport	biological_process	molecular_function	cellular_component
YNL307C	YNL307C	MCK1	hom	Verified	1.42773503315131	0.0766840692517123	no	492	0.0991492459865677	424	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION|CHROMOSOME SEGREGATION			Protein serine/threonine/tyrosine (dual-specificity) kinase; involved in control of chromosome segregation and in regulating entry into meiosis; interacts with Clb2p and Mih1p; inhibits Clb2p-Cdk1 activity; related to mammalian glycogen synthase kinases of the GSK-3 family	meiosis|double-strand break repair via nonhomologous end joining|ascospore formation|protein phosphorylation|response to stress|mitotic sister chromatid segregation	protein serine/threonine/tyrosine kinase activity|protein serine/threonine kinase activity|protein kinase activity	cellular_component
YEL051W	YEL051W	VMA8	hom	Verified	1.42648408874246	0.0768643282609876	no	493	0.0961771020943569	348	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Subunit D of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; plays a role in the coupling of proton transport and ATP hydrolysis	vacuolar acidification	proton-transporting ATPase activity, rotational mechanism	fungal-type vacuole membrane|vacuolar proton-transporting V-type ATPase, V1 domain|integral to membrane
YGR084C	YGR084C	MRP13	hom	Verified	1.42439170096865	0.0771665576294498	no	494	0.060297079303659	274	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the small subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YGR093W_p	YGR093W	YGR093W	hom	Uncharacterized	1.42319062119927	0.0773404518405885	no	495	0.0723565888477428	293	NA	FT		NUCLEUS		Putative protein of unconfirmed function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus	biological_process	molecular_function	nucleus
YIL014C-A_p	YIL014C-A	YIL014C-A	hom	Uncharacterized	1.42221068671665	0.0774825486593224	no	496	0.0918973889540496	369	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YHL043W	YHL043W	ECM34	hom	Verified	1.42202045388858	0.0775101566114984	no	497	0.0610538639924217	241	NA	FT	CELL WALL ORG/BIOGENESIS			Putative protein of unknown function; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins	fungal-type cell wall organization	molecular_function	cellular_component
YDR033W	YDR033W	MRH1	hom	Verified	1.42147500602963	0.0775893573317119	no	498	0.0775873033949334	318	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION|PLASMA MEMBRANE		Protein that localizes primarily to the plasma membrane; also found at the nuclear envelope; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; MRH1 has a paralog, YRO2, that arose from the whole genome duplication	biological_process	molecular_function	mitochondrion|integral to membrane|plasma membrane
YLR178C	YLR178C	TFS1	hom	Verified	1.42075387060872	0.0776941627329273	no	499	0.0487994900418087	215	NA	FT	SIGNALING|PROTEOLYSIS			Protein that interacts with and inhibits carboxypeptidase Y and Ira2p; phosphatidylethanolamine-binding protein (PEBP) family member; targets to vacuolar membranes during stationary phase; acetylated by NatB N-terminal acetyltransferase; protein abundance increases in response to DNA replication stress	regulation of Ras protein signal transduction|regulation of proteolysis	lipid binding|peptidase inhibitor activity|phospholipid binding	fungal-type vacuole lumen|fungal-type vacuole membrane|cytoplasm
YPL038W	YPL038W	MET31	hom	Verified	1.41903870327348	0.0779438663754848	no	500	0.0820622876954112	344	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Zinc-finger DNA-binding transcription factor; involved in transcriptional regulation of the methionine biosynthetic genes; MET31 has a paralog, MET32, that arose from the whole genome duplication	regulation of sulfur amino acid metabolic process|regulation of transcription from RNA polymerase II promoter	core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity	nucleus|cytoplasm
YCR008W	YCR008W	SAT4	hom	Verified	1.41889407987794	0.0779649492641774	no	501	0.0788150719495353	361	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|ION HOMEOSTASIS|PROTEIN PHOSPHORYLATION|ION HOMEOSTASIS			Ser/Thr protein kinase involved in salt tolerance; funtions in regulation of Trk1p-Trk2p potassium transporter; partially redundant with Hal5p; has similarity to Npr1p	cellular cation homeostasis|protein phosphorylation|cellular protein localization|G1/S transition of mitotic cell cycle|protein dephosphorylation	protein kinase activity	cellular_component
YDR312W	YDR312W	SSF2	hom	Verified	1.41826176843834	0.0780571770894103	no	502	0.0521043434458233	232	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS	NUCLEUS		Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication	conjugation with cellular fusion|ribosomal large subunit assembly	rRNA binding	nucleolus
YKL050C	YKL050C	YKL050C	hom	Verified	1.4150471762594	0.078527332232763	no	503	0.0442320901152582	196	NA					Protein of unknown function; the YKL050W protein is a target of the SCFCdc4 ubiquitin ligase complex and YKL050W transcription is regulated by Azf1p	biological_process	molecular_function	cellular_component
YGL063W	YGL063W	PUS2	hom	Verified	1.41482885542805	0.0785593407604901	no	504	0.0771895371373706	351	NA	FT	RNA PROCESSING	MITOCHONDRION		Mitochondrial tRNA:pseudouridine synthase; acts at positions 27 and 28, but not at position 72; efficiently and rapidly targeted to mitochondria, specifically dedicated to mitochondrial tRNA modification	tRNA pseudouridine synthesis	pseudouridine synthase activity	mitochondrion
YDR330W	YDR330W	UBX5	hom	Verified	1.41383936719182	0.078704535938824	no	505	0.0532539044020686	203	NA	FT	PROTEOLYSIS	NUCLEUS		UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p	proteasomal ubiquitin-dependent protein catabolic process	molecular_function	nucleus|cytoplasm
YDR421W	YDR421W	ARO80	hom	Verified	1.41376218906127	0.0787158694200003	no	506	0.048619254259125	223	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Zinc finger transcriptional activator of the Zn2Cys6 family; activates transcription of aromatic amino acid catabolic genes in the presence of aromatic amino acids	aromatic amino acid family catabolic process|positive regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|nucleic acid binding transcription factor activity	nucleus
YMR012W	YMR012W	CLU1	hom	Verified	1.40958253617039	0.0793314933300134	no	507	0.0701821036658069	291	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION			eIF3 component of unknown function; deletion causes defects in mitochondrial organization but not in growth or translation initiation, can rescue cytokinesis and mitochondrial organization defects of the Dictyostelium cluA- mutant	translational initiation|mitochondrion organization	molecular_function	eukaryotic translation initiation factor 3 complex|cytoplasm
YLR344W	YLR344W	RPL26A	hom	Verified	1.4083572665587	0.0795126531503372	no	508	0.068377607607591	292	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L26A; binds to 5.8S rRNA; homologous to mammalian ribosomal protein L26 and bacterial L24; RPL26A has a paralog, RPL26B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome|RNA binding	cytosolic large ribosomal subunit
YMR297W	YMR297W	PRC1	hom	Verified	1.40664623521191	0.0797661579082058	no	509	0.0523911128121679	220	NA	FT	PROTEOLYSIS	ENDOPLASMIC RETICULUM		Vacuolar carboxypeptidase Y (proteinase C; CPY), broad-specificity C-terminal exopeptidase involved in non-specific protein degradation in the vacuole; member of the serine carboxypeptidase family	vacuolar protein catabolic process|phytochelatin biosynthetic process	serine-type carboxypeptidase activity	fungal-type vacuole lumen|endoplasmic reticulum|fungal-type vacuole|cytoplasm
YOR016C	YOR016C	ERP4	hom	Verified	1.40450074327319	0.0800848952501757	no	510	0.0662857287142869	235	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport	ER to Golgi vesicle-mediated transport	molecular_function	integral to membrane
YMR065W	YMR065W	KAR5	hom	Verified	1.4043079877088	0.0801135783627592	no	511	0.078738230754513	352	NA	FT		ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|MITOCHONDRION		Protein required for nuclear membrane fusion during karyogamy, localizes to the membrane with a soluble portion in the endoplasmic reticulum lumen, may form a complex with Jem1p and Kar2p; expression of the gene is regulated by pheromone	karyogamy involved in conjugation with cellular fusion	molecular_function	mitochondrion|endoplasmic reticulum membrane
YML034C-A_d	YML034C-A	YML034C-A	hom	Dubious	1.40346476663447	0.080239145702499	no	512	0.0924398976507795	389	NA					Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YER131W	YER131W	RPS26B	hom	Verified	1.40243560363885	0.0803926038728135	no	513	0.083423359389001	328	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S26, no bacterial homolog; RPS26B has a paralog, RPS26A, that arose from the whole genome duplication	cytoplasmic translation|rRNA export from nucleus	structural constituent of ribosome	cytosolic small ribosomal subunit
YPR106W	YPR106W	ISR1	hom	Verified	1.40154648015921	0.0805253592520581	no	514	0.0847063203443689	355	NA	FT	PROTEIN PHOSPHORYLATION			Predicted protein kinase, overexpression causes sensitivity to staurosporine, which is a potent inhibitor of protein kinase C	biological_process	protein kinase activity	cellular_component
YPL002C	YPL002C	SNF8	hom	Verified	1.39968817680765	0.0808033579218034	no	515	0.103888545672972	450	NA	FF|FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|PROTEOLYSIS|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS			Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; appears to be functionally related to SNF7; involved in glucose derepression	negative regulation of transcription from RNA polymerase II promoter by glucose|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|protein targeting to vacuole	molecular_function	ESCRT II complex
YMR011W	YMR011W	HXT2	hom	Verified	1.39784890497244	0.0810792224531258	no	516	0.0794682666946711	368	NA	FT		PLASMA MEMBRANE		High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose	glucose transport	pentose transmembrane transporter activity|mannose transmembrane transporter activity|fructose transmembrane transporter activity|glucose transmembrane transporter activity	integral to membrane|plasma membrane
YBR264C	YBR264C	YPT10	hom	Verified	1.39782596207413	0.0810826680431804	no	517	0.0792921512155033	310	NA	FT	PROTEIN LOCALIZATION|SIGNALING	PLASMA MEMBRANE		Rab family GTP-binding protein that contains the PEST signal sequence specific for proteolytic enzymes; may be involved in vesicular transport; overexpression leads to accumulation of Golgi-like cisternae with budding vesicles	Golgi organization	GTPase activity|guanyl nucleotide binding	cytoplasm
YER065C	YER065C	ICL1	hom	Verified	1.39495060055704	0.0815153683551987	no	518	0.0608409349834087	246	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM			Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose	glyoxylate cycle	isocitrate lyase activity	cellular_component
YLR287C_p	YLR287C	YLR287C	hom	Uncharacterized	1.39434223250253	0.0816071417298819	no	519	0.0680913437143326	260	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR287C is not an essential gene	biological_process	molecular_function	cytoplasm
YGL259W_p	YGL259W	YPS5	hom	Uncharacterized	1.3942813377653	0.0816163320938852	no	520	0.070675977750884	278	NA	FT	PROTEOLYSIS			Protein with similarity to GPI-anchored aspartic proteases such as Yap1p and Yap3p	biological_process	aspartic-type endopeptidase activity	cellular_component
YKL010C	YKL010C	UFD4	hom	Verified	1.39390928334113	0.0816725002932913	no	521	0.0807217939019022	289	NA	FT	PROTEOLYSIS	MITOCHONDRION		Ubiquitin-protein ligase (E3); interacts with Rpt4p and Rpt6p, two subunits of the 19S particle of the 26S proteasome; cytoplasmic E3 involved in the degradation of ubiquitin fusion proteins; relative distribution to the nucleus increases upon DNA replication stress	protein monoubiquitination|protein polyubiquitination	ubiquitin-protein ligase activity	mitochondrion|cytoplasm
YDR139C	YDR139C	RUB1	hom	Verified	1.39321040375825	0.0817780873108599	no	522	0.0569671318019587	252	NA					Ubiquitin-like protein with similarity to mammalian NEDD8; conjugation (neddylation) substrates include the cullins Cdc53p, Rtt101p, and Cul3p; activated by Ula1p and Uba3p (E1 enzyme pair); conjugation mediated by Ubc12p (E2 enzyme)	protein neddylation	protein tag	cytoplasm
YPL248C	YPL248C	GAL4	hom	Verified	1.39268496725503	0.081857538209381	no	523	0.0696561401494136	301	NA	FT	TRANSCRIPTION FROM RNA POL II|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		DNA-binding transcription factor required for the activation of the GAL genes in response to galactose; repressed by Gal80p and activated by Gal3p	galactose metabolic process|positive regulation of transcription from RNA polymerase II promoter by galactose	RNA polymerase II transcription factor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity	nucleus
YJR084W	YJR084W	YJR084W	hom	Verified	1.39266536290998	0.0818605036945079	no	524	0.0610600241684554	255	NA	FT	RNA PROCESSING|SIGNALING	NUCLEUS|CHROMOSOME		Protein that forms a complex with Thp3p; may have a role in transcription elongation and/or mRNA splicing; identified as a COP9 signalosome component but phenotype and interactions suggest it may not be involved with the signalosome	adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion|mRNA splicing, via spliceosome	molecular_function	transcriptionally active chromatin
YBR052C	YBR052C	RFS1	hom	Verified	1.39069900059802	0.0821583604077528	no	525	0.0467919054378974	249	NA	FT	OXIDATION-REDUCTION PROCESS			Protein of unknown function; member of a flavodoxin-like fold protein family that includes Pst2p and Ycp4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; RFS1 has a paralog, PST2, that arose from the whole genome duplication	biological_process	molecular_function	membrane raft|cytoplasm
YBR062C_p	YBR062C	YBR062C	hom	Uncharacterized	1.38880684419848	0.0824457467419888	no	526	0.065210274614277	269	NA					Protein of unknown function that interacts with Msb2p; may play a role in activation of the filamentous growth pathway.	biological_process	molecular_function	cellular_component
YEL001C	YEL001C	IRC22	hom	Verified	1.38858769158729	0.0824790811374147	no	527	0.055668541447484	221	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Putative protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; YEL001C is non-essential; null mutant displays increased levels of spontaneous Rad52p foci	biological_process	molecular_function	endoplasmic reticulum
YDR344C_d	YDR344C	YDR344C	hom	Dubious	1.38844447080458	0.0825008713387428	no	528	0.0805723885140913	314	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YGL017W	YGL017W	ATE1	hom	Verified	1.38552649209247	0.0829457688150589	no	529	0.0630883485681245	255	NA	FT	PROTEOLYSIS			Arginyl-tRNA-protein transferase, catalyzes post-translational conjugation of arginine to the amino termini of acceptor proteins which are then subject to degradation via the N-end rule pathway	cellular protein modification process|protein arginylation	arginyltransferase activity	cytoplasm
YDR186C	YDR186C	YDR186C	hom	Verified	1.38488096710361	0.0830444338589476	no	530	0.0757966413783327	343	NA					Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	biological_process	molecular_function	ribosome|cytoplasm
YPR155C	YPR155C	NCA2	hom	Verified	1.38445714679898	0.0831092605119518	no	531	0.0658054839815984	315	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Protein involved in regulation of mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p) of the Fo-F1 ATP synthase; functions with Nca3p	mRNA metabolic process|aerobic respiration	molecular_function	mitochondrial outer membrane|mitochondrion
YJR021C	YJR021C	REC107	hom	Verified	1.38422847709797	0.0831442531454204	no	532	0.0796688346393493	334	NA	FT	CELL CYCLE	NUCLEUS|CHROMOSOME		Protein involved in early stages of meiotic recombination; involved in coordination between the initiation of recombination and the first division of meiosis; part of a complex (Rec107p-Mei4p-Rec114p) required for ds break formation	reciprocal meiotic recombination	molecular_function	condensed nuclear chromosome
YAL062W	YAL062W	GDH3	hom	Verified	1.38053850527043	0.0837104512513647	no	533	0.0653124227075835	264	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS	NUCLEUS|MITOCHONDRION		NADP(+)-dependent glutamate dehydrogenase; synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources; GDH3 has a paralog, GDH1, that arose from the whole genome duplication	glutamate biosynthetic process|ammonia assimilation cycle	glutamate dehydrogenase (NADP+) activity	mitochondrion|nucleus
YOR276W	YOR276W	CAF20	hom	Verified	1.37755118472792	0.0841709506661307	no	534	0.0776920726766765	298	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION			Phosphoprotein of the mRNA cap-binding complex involved in translational control, repressor of cap-dependent translation initiation, competes with eIF4G for binding to eIF4E	negative regulation of translation|positive regulation of cytoplasmic mRNA processing body assembly	translation regulator activity	mRNA cap binding complex
YDR430C	YDR430C	CYM1	hom	Verified	1.37620098333262	0.0843797088780435	no	535	0.0575806714819771	199	NA	FT	PROTEOLYSIS	MITOCHONDRION		Lysine-specific metalloprotease of the mitochondrial intermembrane space, member of the pitrilysin family; degrades proteins and presequence peptides cleaved from imported proteins; required for normal mitochondrial morphology	proteolysis|proteolysis involved in cellular protein catabolic process	metalloendopeptidase activity	mitochondrion|mitochondrial intermembrane space
YBR263W	YBR263W	SHM1	hom	Verified	1.37574204187885	0.0844507554299681	no	536	0.0558789878698897	217	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		Mitochondrial serine hydroxymethyltransferase, converts serine to glycine plus 5,10 methylenetetrahydrofolate; involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis; reverse reaction generates serine	serine family amino acid biosynthetic process|one-carbon metabolic process	glycine hydroxymethyltransferase activity	mitochondrion
YJL013C	YJL013C	MAD3	hom	Verified	1.37532763271304	0.0845149467011037	no	537	0.0680722101288327	295	NA	FT	CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION	NUCLEUS		Subunit of the spindle-assembly checkpoint complex, which delays anaphase onset in cells with defects in mitotic spindle assembly; pseudosubstrate inhibitor of APC(Cdc20), the anaphase promoting complex involved in securin (Pds1p) turnover	distributive segregation|mitotic cell cycle spindle assembly checkpoint|mitotic cell cycle G2/M transition decatenation checkpoint	molecular_function	mitotic checkpoint complex
YOR040W	YOR040W	GLO4	hom	Verified	1.37289882626291	0.084891900769022	no	538	0.0655286272367902	262	NA	FT	KETONE METABOLISM|CARBOHYDRATE METABOLISM	MITOCHONDRION		Mitochondrial glyoxalase II, catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate	cellular carbohydrate metabolic process|methylglyoxal catabolic process to D-lactate	hydroxyacylglutathione hydrolase activity	mitochondrion|mitochondrial matrix
YOR306C	YOR306C	MCH5	hom	Verified	1.37003831583974	0.0853374706543264	no	539	0.066195800690645	261	NA	FT		PLASMA MEMBRANE		Plasma membrane riboflavin transporter; facilitates the uptake of vitamin B2; required for FAD-dependent processes; sequence similarity to mammalian monocarboxylate permeases, however mutants are not deficient in monocarboxylate transport	riboflavin transport	monocarboxylic acid transmembrane transporter activity|riboflavin transporter activity	integral to membrane|plasma membrane
YDR467C_d	YDR467C	YDR467C	hom	Dubious	1.36860135479633	0.0855619601491494	no	540	0.0929356066106266	330	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDL085W	YDL085W	NDE2	hom	Verified	1.36787662013676	0.0856753495730787	no	541	0.0652156630865636	267	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Mitochondrial external NADH dehydrogenase, catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p are involved in providing the cytosolic NADH to the mitochondrial respiratory chain	glucose catabolic process to ethanol|NADH oxidation	NADH dehydrogenase activity	mitochondrion
YKR090W	YKR090W	PXL1	hom	Verified	1.36753961599563	0.0857281143540612	no	542	0.0871115423558872	384	NA	FT	SIGNALING	SITE OF POLARIZED GROWTH		Protein that localizes to sites of polarized growth; required for selection and/or maintenance of polarized growth sites, may modulate signaling by the GTPases Cdc42p and Rho1p; contains LIM domains and has similarity to metazoan paxillin; relocalizes from bud neck to cytoplasm upon DNA replication stress	maintenance of cell polarity|regulation of Rho protein signal transduction	Rho GDP-dissociation inhibitor activity	incipient cellular bud site|cellular bud|mating projection tip|cellular bud neck|cytoplasm|cellular bud tip
YOR171C	YOR171C	LCB4	hom	Verified	1.36559774943338	0.0860326266770118	no	543	0.0679238898192854	289	NA	FT	LIPID METABOLISM|SIGNALING|PROTEIN PHOSPHORYLATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS|PLASMA MEMBRANE		Sphingoid long-chain base kinase, responsible for synthesis of long-chain base phosphates, which function as signaling molecules, regulates synthesis of ceramide from exogenous long-chain bases, localizes to the Golgi and late endosomes	calcium-mediated signaling|sphingolipid metabolic process	D-erythro-sphingosine kinase activity	Golgi apparatus|endoplasmic reticulum|plasma membrane|cortical endoplasmic reticulum
YER044C-A	YER044C-A	MEI4	hom	Verified	1.36318248549321	0.0864125028473182	no	544	0.0785801590384528	335	NA	FT	CELL CYCLE	NUCLEUS|CHROMOSOME		Meiosis-specific protein involved in double-strand break formation during meiotic recombination; required for chromosome synapsis and production of viable spores	meiotic DNA double-strand break formation	molecular_function	condensed nuclear chromosome
YHR097C_p	YHR097C	YHR097C	hom	Uncharacterized	1.36227415193538	0.086555690915247	no	545	0.0833548286265902	326	NA	FT		NUCLEUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus	biological_process	molecular_function	nucleus|cytoplasm
YOR069W	YOR069W	VPS5	hom	Verified	1.361028038078	0.086752414524181	no	546	0.101282928613345	386	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Nexin-1 homolog required for localizing membrane proteins from a prevacuolar/late endosomal compartment back to the late Golgi apparatus; structural component of the retromer membrane coat complex; forms a retromer subcomplex with Vps17p; required for recruiting the retromer complex to the endosome membranes	protein retention in Golgi apparatus|retrograde transport, endosome to Golgi	protein transporter activity|phosphatidylinositol-3-phosphate binding	cytosol|endosome|retromer complex, outer shell|retromer complex
YLL012W	YLL012W	YEH1	hom	Verified	1.35770145464659	0.0872792175220765	no	547	0.0648914712683032	228	NA	FT	LIPID METABOLISM			Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes	sterol metabolic process	sterol esterase activity	integral to membrane|lipid particle
YHR127W	YHR127W	YHR127W	hom	Verified	1.35622548980639	0.0875137171015425	no	548	0.0773108444069863	290	NA	FT	CELL CYCLE|CYTOSKELETON ORGANIZATION	NUCLEUS		Protein of unknown function; localizes to the nucleus; required for asymmetric localization of Kar9p during mitosis	mitotic spindle elongation	molecular_function	nucleus
YHR017W	YHR017W	YSC83	hom	Verified	1.3551195050572	0.087689742614088	no	549	0.114613418753279	487	NA	FT		MITOCHONDRION		Non-essential mitochondrial protein of unknown function; mRNA induced during meiosis, peaking between mid to late prophase of meiosis I; similar to S. douglasii YSD83	biological_process	molecular_function	mitochondrial outer membrane|mitochondrion
YMR151W_d	YMR151W	YIM2	hom	Dubious	1.35482224298251	0.0877370990433097	no	550	0.0826155420270112	308	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1	Unknown	Unknown	Unknown
YNL045W	YNL045W	LAP2	hom	Verified	1.35407266714498	0.0878565976878628	no	551	0.0748163307460865	293	NA	FT	KETONE METABOLISM|LIPID METABOLISM|PROTEOLYSIS	NUCLEUS		Leucyl aminopeptidase yscIV (leukotriene A4 hydrolase) with epoxide hydrolase activity, metalloenzyme containing one zinc atom; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus	cellular lipid metabolic process|protein catabolic process	aminopeptidase activity|leukotriene-A4 hydrolase activity|epoxide hydrolase activity	nucleus|cytoplasm
YCR027C	YCR027C	RHB1	hom	Verified	1.35337892175016	0.0879673038769884	no	552	0.0910078123409725	353	NA	FT	VESICLE-MEDIATED TRANSPORT|SIGNALING|NUCLEOTIDE METABOLISM	PLASMA MEMBRANE		Putative Rheb-related GTPase involved in regulating canavanine resistance and arginine uptake; member of the Ras superfamily of G-proteins	lysine transport|retrograde transport, endosome to Golgi|arginine transport	GTPase activity	extrinsic to plasma membrane
YJL068C	YJL068C	YJL068C	hom	Verified	1.35256120722496	0.0880979262846324	no	553	0.0715546676356816	302	NA					Non-essential intracellular esterase that can function as an S-formylglutathione hydrolase; may be involved in the detoxification of formaldehyde, which can be metabolized to S-formylglutathione; similar to human esterase D	formaldehyde catabolic process	S-formylglutathione hydrolase activity	cytosol
YDR295C	YDR295C	HDA2	hom	Verified	1.35239206369554	0.088124963454581	no	554	0.0710332347600999	259	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS|CHROMOSOME		Subunit of a possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex containing an Hda1p homodimer and an Hda2p-Hda3p heterodimer; involved in telomere maintenance	negative regulation of transcription from RNA polymerase II promoter|gene silencing by RNA|histone deacetylation|gene silencing involved in chronological cell aging	histone deacetylase activity|chromatin binding|DNA binding	nucleus|HDA1 complex
YAL018C_p	YAL018C	YAL018C	hom	Uncharacterized	1.35235671696528	0.0881306143223049	no	555	0.0941554063542684	325	NA					Putative protein of unknown function	biological_process	molecular_function	integral to membrane
YGL114W_p	YGL114W	YGL114W	hom	Uncharacterized	1.35222081879427	0.0881523428247262	no	556	0.0604379914103014	217	NA	FT	PROTEIN LOCALIZATION			Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters	transport	oligopeptide transporter activity	integral to membrane|membrane
YDR471W	YDR471W	RPL27B	hom	Verified	1.35042329930323	0.0884401206830714	no	557	0.0849815726977586	320	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L27B; homologous to mammalian ribosomal protein L27, no bacterial homolog; RPL27B has a paralog, RPL27A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YKR024C	YKR024C	DBP7	hom	Verified	1.35042226757863	0.0884402860600638	no	558	0.0877749730045543	374	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Putative ATP-dependent RNA helicase of the DEAD-box family involved in ribosomal biogenesis; essential for growth under anaerobic conditions	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	ATP-dependent RNA helicase activity	nucleolus
YNL129W	YNL129W	NRK1	hom	Verified	1.34818647510856	0.0887992067739436	no	559	0.0665726041899617	234	NA	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM			Nicotinamide riboside kinase, catalyzes the phosphorylation of nicotinamide riboside and nicotinic acid riboside in salvage pathways for NAD+ biosynthesis	nicotinamide riboside metabolic process|NAD biosynthesis via nicotinamide riboside salvage pathway|NAD biosynthetic process	nicotinic acid riboside kinase activity|ribosylnicotinamide kinase activity	cytoplasm
YJR031C	YJR031C	GEA1	hom	Verified	1.3458238314892	0.0891796689108243	no	560	0.0770125985866888	289	NA	FT	VESICLE-MEDIATED TRANSPORT|SIGNALING|CYTOSKELETON ORGANIZATION|RESPONSE TO NUTRIENT LEVELS	GOLGI APPARATUS		Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs); involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; GEA1 has a paralog, GEA2, that arose from the whole genome duplication	retrograde vesicle-mediated transport, Golgi to ER|ER to Golgi vesicle-mediated transport|macroautophagy|intra-Golgi vesicle-mediated transport|actin cytoskeleton organization	ARF guanyl-nucleotide exchange factor activity	integral to membrane|Golgi cis cisterna|Golgi-associated vesicle|extrinsic to membrane
YBL106C	YBL106C	SRO77	hom	Verified	1.34529079223896	0.0892656729530966	no	561	0.130917052968512	530	NA	FF|FT	VESICLE-MEDIATED TRANSPORT	PLASMA MEMBRANE		Protein with roles in exocytosis and cation homeostasis; functions in docking and fusion of post-Golgi vesicles with plasma membrane; homolog of Drosophila lethal giant larvae tumor suppressor; interacts with SNARE protein Sec9p; SRO77 has a paralog, SRO7, that arose from the whole genome duplication	exocytosis|Golgi to plasma membrane transport	molecular_function	plasma membrane
YBL054W	YBL054W	TOD6	hom	Verified	1.34345981192411	0.0895615653596076	no	562	0.0886292144556207	323	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS|CHROMOSOME		PAC motif binding protein involved in rRNA and ribosome biogenesis; subunit of the RPD3L histone deacetylase complex; Myb-like HTH transcription factor; hypophosphorylated by rapamycin treatment in a Sch9p-dependent manner; TOD6 has a paralog, DOT6, that arose from the whole genome duplication	regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding	Rpd3L-Expanded complex|nucleus|Rpd3L complex|cytoplasm
YMR279C	YMR279C	YMR279C	hom	Verified	1.34168169016769	0.0898496131354975	no	563	0.108802208538328	406	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Putative boron transporter involved in boron efflux and resistance; overexpression mutant but not null mutant displays boron tolerance phenotype; identified as a heat-induced gene in a high-throughout screen; YMR279C is not an essential gene; YMR279C has a paralog, ATR1, that arose from the whole genome duplication	borate transmembrane transport	borate efflux transmembrane transporter activity	integral to membrane
YOR307C	YOR307C	SLY41	hom	Verified	1.340903633748	0.0899758711471626	no	564	0.0967666930343024	336	NA	FT	VESICLE-MEDIATED TRANSPORT	ENDOPLASMIC RETICULUM		Protein involved in ER-to-Golgi transport	ER to Golgi vesicle-mediated transport	molecular_function	integral to membrane|endoplasmic reticulum
YDR125C	YDR125C	ECM18	hom	Verified	1.33763526951046	0.0905076806743173	no	565	0.118995144524444	437	NA	FT	CELL WALL ORG/BIOGENESIS	MITOCHONDRION		Protein of unknown function; ECM18 has a paralog, ICT1, that arose from the whole genome duplication	fungal-type cell wall organization	molecular_function	mitochondrion
YLR288C	YLR288C	MEC3	hom	Verified	1.3366444272077	0.090669364931595	no	566	0.0697362194109463	272	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|GENE SILENCING	NUCLEUS|CHROMOSOME		DNA damage and meiotic pachytene checkpoint protein; subunit of a heterotrimeric complex (Rad17p-Mec3p-Ddc1p) that forms a sliding clamp, loaded onto partial duplex DNA by a clamp loader complex; homolog of human and S. pombe Hus1	telomere maintenance via recombination|DNA damage checkpoint|DNA metabolic process|chromatin silencing at telomere	DNA binding	nucleus|checkpoint clamp complex
YGR146C	YGR146C	ECL1	hom	Verified	1.33639390059769	0.0907102794459207	no	567	0.0962071655938464	347	NA					Protein of unknown function; mitochondrial-dependent role in the extension of chronological lifespan; overexpression increases oxygen consumption and respiratory activity while deletion results in reduced oxygen consumption under conditions of caloric restriction; induced by iron homeostasis transcription factor Aft2p; multicopy suppressor of temperature sensitive hsf1 mutant; induced by treatment with 8-methoxypsoralen and UVA irradiation	biological_process	molecular_function	cellular_component
YPL084W	YPL084W	BRO1	hom	Verified	1.33407095763931	0.0910903013906123	no	568	0.096390531310256	431	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEOLYSIS|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS			Cytoplasmic class E vacuolar protein sorting (VPS) factor that coordinates deubiquitination in the multivesicular body (MVB) pathway by recruiting Doa4p to endosomes	protein deubiquitination|vacuolar transport|protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|response to nutrient|ubiquitin-dependent protein catabolic process	ubiquitin-specific protease activity	endosome|cytoplasm
YBL053W_d	YBL053W	YBL053W	hom	Dubious	1.33320227020044	0.0912327172783218	no	569	0.0860843460698756	343	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YLL039C	YLL039C	UBI4	hom	Verified	1.33304365732664	0.0912587386848372	no	570	0.0711009560706069	262	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		Ubiquitin; becomes conjugated to proteins, marking them for selective degradation via the ubiquitin-26S proteasome system; essential for the cellular stress response; encoded as a polyubiquitin precursor comprised of 5 head-to-tail repeats; protein abundance increases in response to DNA replication stress	protein deubiquitination|ascospore formation|protein monoubiquitination|protein polyubiquitination|protein ubiquitination|response to stress	ATP-dependent protein binding|protein tag	cytoplasm
YER033C	YER033C	ZRG8	hom	Verified	1.33239601446292	0.0913650455438226	no	571	0.0952200795228972	379	NA	FT	CELL WALL ORG/BIOGENESIS	MITOCHONDRION|SITE OF POLARIZED GROWTH		Protein of unknown function; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; GFP-fusion protein is localized to the cytoplasm; transcription induced under conditions of zinc deficiency	fungal-type cell wall organization	molecular_function	mitochondrion|cellular bud|cellular bud neck|mating projection tip|cytoplasm
YDL201W	YDL201W	TRM8	hom	Verified	1.33157230092805	0.0915003859873744	no	572	0.0698916309693973	275	NA	FT	RNA PROCESSING	NUCLEUS		Noncatalytic subunit of a tRNA methyltransferase complex; Trm8p and Trm82p comprise an enzyme that catalyzes a methyl-transfer from S-adenosyl-l-methionine to the N(7) atom of guanine at position 46 in tRNA; Trm8 lacks catalytic activity if not bound to Trm82p	tRNA methylation	tRNA (guanine-N7-)-methyltransferase activity	tRNA methyltransferase complex|nucleus
YJL136W-A_p	YJL136W-A	YJL136W-A	hom	Uncharacterized	1.33108131932272	0.0915811274798546	no	573	0.0631880997223446	223	NA					Putative protein of unknown function; identified by SAGE	biological_process	molecular_function	cellular_component
YIL114C	YIL114C	POR2	hom	Verified	1.33083219355721	0.0916221161781084	no	574	0.0897976849754062	303	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Putative mitochondrial porin (voltage-dependent anion channel); not required for mitochondrial membrane permeability or mitochondrial osmotic stability; POR2 has a paralog, POR1, that arose from the whole genome duplication	DNA transport|ion transport|cell redox homeostasis	voltage-gated anion channel activity	mitochondrial outer membrane|mitochondrion|integral to membrane
YOR099W	YOR099W	KTR1	hom	Verified	1.33014164339612	0.0917358035553826	no	575	0.0758581809743726	341	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Alpha-1,2-mannosyltransferase; involved in O- and N-linked protein glycosylation; type II membrane protein; member of the KRE2/MNT1 mannosyltransferase family; relocalizes from vacuole to cytoplasm upon DNA replication stress	N-glycan processing|cell wall mannoprotein biosynthetic process|protein O-linked glycosylation	alpha-1,2-mannosyltransferase activity	Golgi apparatus
YLL061W	YLL061W	MMP1	hom	Verified	1.32467666900607	0.0926392073246251	no	576	0.0792764669594949	327	NA	FT		ENDOPLASMIC RETICULUM|PLASMA MEMBRANE		High-affinity S-methylmethionine permease, required for utilization of S-methylmethionine as a sulfur source; has similarity to S-adenosylmethionine permease Sam3p	S-methylmethionine transport	S-methylmethionine transmembrane transporter activity	integral to membrane|plasma membrane
YFL051C_p	YFL051C	YFL051C	hom	Uncharacterized	1.32429606778612	0.0927023679797308	no	577	0.071005871140768	277	NA	FT		PLASMA MEMBRANE		Putative protein of unknown function; YFL051C is not an essential gene	biological_process	molecular_function	cellular_component
YBR025C	YBR025C	OLA1	hom	Verified	1.32419091065435	0.0927198243873912	no	578	0.094960650125164	398	NA					P-loop ATPase with similarity to human OLA1 and bacterial YchF; identified as specifically interacting with the proteasome; protein abundance increases in response to hydrogen peroxide and to DNA replication stress	biological_process	ATPase activity	cytoplasm
YDR075W	YDR075W	PPH3	hom	Verified	1.32084119007177	0.093277161161398	no	579	0.0719801037708026	316	NA	FT	CELL CYCLE|SIGNALING|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Catalytic subunit of protein phosphatase PP4 complex; active complex is composed of Pph3p and Psy2p, with Psy4p apparently providing additional substrate specificity in some cases; regulates recovery from the DNA damage checkpoint and also the gene conversion- and single-strand annealing-mediated pathways of meiotic double-strand break repair; involved in activation of Gln3p to alleviate nitrogen catabolite repression; Pph3p and Psy2p localize to foci on meiotic chromosomes	Unknown|signal transduction involved in meiotic recombination checkpoint|double-strand break repair via homologous recombination|protein dephosphorylation|positive regulation of nitrogen compound metabolic process	protein serine/threonine phosphatase activity	condensed nuclear chromosome|nucleus|cytoplasm
YLR363W-A	YLR363W-A	YLR363W-A	hom	Verified	1.31881528597087	0.0936154363237937	no	580	0.0650001309458158	293	NA	FT		NUCLEUS		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; relocalizes from nucleus to nucleolus upon DNA replication stress	biological_process	molecular_function	nucleus
YPR184W	YPR184W	GDB1	hom	Verified	1.31629826984522	0.0940369756743124	no	581	0.0941437896261349	422	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS|MITOCHONDRION		Glycogen debranching enzyme; contains glucanotranferase and alpha-1,6-amyloglucosidase activities; required for glycogen degradation; phosphorylated in mitochondria; activity is inhibited by Igd1p; protein abundance increases in response to DNA replication stress	glycogen catabolic process	4-alpha-glucanotransferase activity|amylo-alpha-1,6-glucosidase activity	mitochondrion|cytoplasm
YKL041W	YKL041W	VPS24	hom	Verified	1.3156085192355	0.0941527363489336	no	582	0.111108808679142	440	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|PROTEOLYSIS|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM		One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); forms an ESCRT-III subcomplex with Did4p; involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway	intralumenal vesicle formation|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|late endosome to vacuole transport	molecular_function	ESCRT III complex|cytoplasm
YBR130C	YBR130C	SHE3	hom	Verified	1.31450890118848	0.0943375023132378	no	583	0.0980310817077831	370	NA	FT	RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|SITE OF POLARIZED GROWTH|CYTOSKELETON		Protein that acts as an adaptor between Myo4p and the She2p-mRNA complex; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud; also required for cortical ER inheritance	mating type switching|endoplasmic reticulum inheritance|intracellular mRNA localization	mRNA binding	actin cap|cytoplasm|cellular bud tip
YBR094W	YBR094W	PBY1	hom	Verified	1.30774198120005	0.0954804194784803	no	584	0.0770126670719719	300	NA					Putative tubulin tyrosine ligase associated with P-bodies; forms cytoplasmic foci upon DNA replication stress	nuclear-transcribed mRNA catabolic process|biological_process	molecular_function	cytoplasmic mRNA processing body|cytoplasm
YCL045C	YCL045C	EMC1	hom	Verified	1.30645404426926	0.0956990986853236	no	585	0.0919568784194123	387	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Member of conserved endoplasmic reticulum membrane complex; involved in efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; interacts with Gal80p; homologous to worm H17B01.4/EMC-1, fly CG2943, and human KIAA0090	protein folding in endoplasmic reticulum	molecular_function	ER membrane protein complex|endoplasmic reticulum
YGL186C	YGL186C	TPN1	hom	Verified	1.30552598200701	0.0958569029380874	no	586	0.222760332146964	776	NA	FF|FT		PLASMA MEMBRANE		Plasma membrane pyridoxine (vitamin B6) transporter; member of the purine-cytosine permease subfamily within the major facilitator superfamily; proton symporter with similarity to Fcy21p, Fcy2p, and Fcy22p	vitamin transport	vitamin transporter activity	integral to membrane|plasma membrane
YCR011C	YCR011C	ADP1	hom	Verified	1.30504782996814	0.0959382808004521	no	587	0.0804126703421485	353	NA	FT	NUCLEOTIDE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Putative ATP-dependent permease of the ABC transporter family of proteins	transport|transmembrane transport	ATPase activity, coupled to transmembrane movement of substances	integral to membrane|endoplasmic reticulum|cytoplasm
YLR203C	YLR203C	MSS51	hom	Verified	1.30481088325749	0.0959786261615635	no	588	0.0766854378777499	302	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Specific translational activator for the mitochondrial COX1 mRNA; loosely associated with the matrix face of the mitochondrial inner membrane; influences both COX1 mRNA translation and Cox1p assembly into cytochrome c oxidase; binds to heme B, which may be a mechanism for sensing oxygen levels in order to regulate cytochrome c oxidase biogenesis	mitochondrial respiratory chain complex IV biogenesis|positive regulation of mitochondrial translation	translation regulator activity	extrinsic to mitochondrial inner membrane|mitochondrion
YML013W	YML013W	UBX2	hom	Verified	1.30180981226834	0.0964907043360839	no	589	0.144277568796575	593	NA	FF|FT	PROTEOLYSIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION	UBIQUITIN LIGASE COMPLEX	Bridging factor involved in ER-associated protein degradation (ERAD); bridges the cytosolic Cdc48p-Npl1p-Ufd1p ATPase complex and the membrane associated Ssm4p and Hrd1p ubiquitin ligase complexes; contains a UBX (ubiquitin regulatory X) domain and a ubiquitin-associated (UBA) domain; redistributes from the ER to lipid droplets during the diauxic shift and stationary phase; required for the maintenance of lipid homeostasis	proteasomal ubiquitin-dependent protein catabolic process|ER-associated protein catabolic process|lipid particle organization	protein binding, bridging	mitochondrial outer membrane|Doa10p ubiquitin ligase complex|integral to endoplasmic reticulum membrane|lipid particle|endoplasmic reticulum
YDR140W	YDR140W	MTQ2	hom	Verified	1.30086546527675	0.096652254441042	no	590	0.0886591531921086	376	NA	FT	TRANSLATION	NUCLEUS		S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; subunit of complex with Trm112p that methylates translation release factor Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; similar to E.coli PrmC	peptidyl-glutamine methylation|regulation of translation	protein methyltransferase activity|S-adenosylmethionine-dependent methyltransferase activity	eRF1 methyltransferase complex|nucleus|cytoplasm
YGR122C-A_d	YGR122C-A	YGR122C-A	hom	Dubious	1.29774576860842	0.0971873553035361	no	591	0.0744188731731892	314	NA					Dubious open reading frame unlikely to encode a functional protein, similar to YLR334C and YOL106W	Unknown	Unknown	Unknown
YBR260C	YBR260C	RGD1	hom	Verified	1.29630896140028	0.0974345312080119	no	592	0.0742716374584832	309	NA	FT	SIGNALING	SITE OF POLARIZED GROWTH|CYTOSKELETON		GTPase-activating protein (RhoGAP) for Rho3p and Rho4p, possibly involved in control of actin cytoskeleton organization	response to acid|osmosensory signaling pathway	Rho GTPase activator activity|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4-phosphate binding|phosphatidylinositol-5-phosphate binding	cellular bud|mating projection tip|actin cortical patch
YAL029C	YAL029C	MYO4	hom	Verified	1.29601281255455	0.0974855353646426	no	593	0.0943303083593084	367	NA	FT	RNA LOCALIZATION	MITOCHONDRION|SITE OF POLARIZED GROWTH|CYTOSKELETON		Type V myosin motor involved in actin-based transport of cargos; required for mRNA transport, including ASH1 mRNA, and facilitating the growth and movement of ER tubules into the growing bud along with She3p; MYO4 has a paralog, MYO2, that arose from the whole genome duplication	mating type switching|endoplasmic reticulum inheritance|intracellular mRNA localization	microfilament motor activity|actin filament binding	mitochondrion|filamentous actin|myosin V complex|cellular bud|cellular bud tip
YNL220W	YNL220W	ADE12	hom	Verified	1.29410671126753	0.0978142818523959	no	594	0.0816303951057482	296	NA	FT	NUCLEOTIDE METABOLISM			Adenylosuccinate synthase, catalyzes the first step in synthesis of adenosine monophosphate from inosine 5'monophosphate during purine nucleotide biosynthesis; exhibits binding to single-stranded autonomously replicating (ARS) core sequence	purine nucleotide biosynthetic process	DNA replication origin binding|adenylosuccinate synthase activity	cytoplasm
YCR076C	YCR076C	FUB1	hom	Verified	1.29280066760132	0.0980400047286561	no	595	0.131168237378715	455	NA					Putative protein of unknown function; interacts physically with multiple subunits of the 20S proteasome and genetically with genes encoding 20S core particle and 19S regulatory particle subunits; exhibits boundary activity which blocks the propagation of heterochromatic silencing; contains a PI31 proteasome regulator domain and sequence similarity with human PSMF1, a proteasome inhibitor; not an essential gene	biological_process	proteasome binding	cellular_component
YBR098W	YBR098W	MMS4	hom	Verified	1.28960477679831	0.0985939581772268	no	596	0.0883958393775055	354	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION	NUCLEUS		Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in recombination, DNA repair, and joint molecule formation/resolution during meiotic recombination; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates the function of Mms4p-Mus81p	DNA repair|DNA topological change|regulation of reciprocal meiotic recombination|reciprocal meiotic recombination|resolution of meiotic recombination intermediates|response to DNA damage stimulus	transcription coactivator activity|endonuclease activity|crossover junction endodeoxyribonuclease activity	Holliday junction resolvase complex|nucleus
YNR039C	YNR039C	ZRG17	hom	Verified	1.2881221284696	0.0988517267574566	no	597	0.0747235772461415	252	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Msc2p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; zinc-regulated directly through Zap1p; transcription induced under conditions of zinc deficiency	zinc ion transport	zinc ion transmembrane transporter activity|metal ion transmembrane transporter activity	integral to membrane|endoplasmic reticulum
YBR299W	YBR299W	MAL32	hom	Verified	1.28781813706034	0.0989046386105549	no	598	0.1039022918089	400	NA	FT	CARBOHYDRATE METABOLISM			Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL3 complex locus; functional in genomic reference strain S288C; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose	sucrose catabolic process|maltose catabolic process	sucrose alpha-glucosidase activity|alpha-glucosidase activity|maltose alpha-glucosidase activity	plasma membrane
YML009C	YML009C	MRPL39	hom	Verified	1.28630351996539	0.0991685772592392	no	599	0.0801884768023924	309	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YBR169C	YBR169C	SSE2	hom	Verified	1.28539164838466	0.0993277290895381	no	600	0.0663927283118567	201	NA					Member of the heat shock protein 70 (HSP70) family; may be involved in protein folding; localized to the cytoplasm; SSE2 has a paralog, SSE1, that arose from the whole genome duplication	protein folding|protein refolding	adenyl-nucleotide exchange factor activity	cytoplasm
YBR195C	YBR195C	MSI1	hom	Verified	1.28445222358918	0.099491885068689	no	601	0.0843563198754452	313	NA	FT	CHROMATIN ORGANIZATION	NUCLEUS		Subunit of chromatin assembly factor I (CAF-1); chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of the DNA damage checkpoint after DNA repair; and chromatin dynamics during transcription; Msi1p localizes to both nucleus and cytoplasm and has an independent role as a negative regulator of the RAS/cAMP pathway via sequestration of Npr1p kinase	DNA replication-dependent nucleosome assembly	histone binding	nucleus|CAF-1 complex|cytoplasm
YCR048W	YCR048W	ARE1	hom	Verified	1.28423438684683	0.099529978371947	no	602	0.0687058304714636	282	NA	FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Acyl-CoA:sterol acyltransferase; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the absence of oxygen; ARE1 has a paralog, ARE2, that arose from the whole genome duplication	sterol metabolic process	ergosterol O-acyltransferase activity|lanosterol O-acyltransferase activity	integral to membrane|endoplasmic reticulum
YCL038C	YCL038C	ATG22	hom	Verified	1.28077702307343	0.100135998384035	no	603	0.0908845884222681	354	NA	FT	PROTEIN LOCALIZATION|VACUOLAR TRANSPORT			Vacuolar integral membrane protein required for efflux of amino acids during autophagic body breakdown in the vacuole; null mutation causes a gradual loss of viability during starvation	amino acid export from vacuole	molecular_function	integral to fungal-type vacuolar membrane|integral to membrane
YDL135C	YDL135C	RDI1	hom	Verified	1.27877800265446	0.100487621138568	no	604	0.0686064478656341	260	NA	FT	MEMBRANE ORGANIZATION|SIGNALING|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH		Rho GDP dissociation inhibitor; involved in the localization and regulation of Cdc42p and Rho1p; protein abundance increases in response to DNA replication stress	regulation of vacuole fusion, non-autophagic|actin filament organization|small GTPase mediated signal transduction	Rho GDP-dissociation inhibitor activity	cytosol|plasma membrane|cellular bud neck|cellular bud tip
YMR150C	YMR150C	IMP1	hom	Verified	1.27622148658668	0.100938617620881	no	605	0.0857020149965105	288	NA	FT	PROTEIN LOCALIZATION|PROTEOLYSIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p	protein processing involved in protein targeting to mitochondrion	endopeptidase activity	mitochondrion|mitochondrial inner membrane peptidase complex
YKL113C	YKL113C	RAD27	hom	Verified	1.27570498376095	0.101029913088576	no	606	0.134569386159256	524	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS|MITOCHONDRION		5' to 3' exonuclease, 5' flap endonuclease, required for Okazaki fragment processing and maturation as well as for long-patch base-excision repair; member of the S. pombe RAD2/FEN1 family	double-strand break repair via nonhomologous end joining|replicative cell aging|DNA replication, removal of RNA primer|base-excision repair, base-free sugar-phosphate removal|gene conversion at mating-type locus, DNA repair synthesis	5'-3' exonuclease activity|5'-flap endonuclease activity	mitochondrion|nucleus
YLR063W_p	YLR063W	YLR063W	hom	Uncharacterized	1.27543087073016	0.101078388914674	no	607	0.0900803001142662	313	NA					Putative S-adenosylmethionine-dependent methyltransferase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR063W is not an essential gene	biological_process	S-adenosylmethionine-dependent methyltransferase activity	cytoplasm
YML113W	YML113W	DAT1	hom	Verified	1.2731683090702	0.101479161763759	no	608	0.087596103483165	331	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		DNA binding protein that recognizes oligo(dA).oligo(dT) tracts; Arg side chain in its N-terminal pentad Gly-Arg-Lys-Pro-Gly repeat is required for DNA-binding; not essential for viability	negative regulation of transcription from RNA polymerase II promoter	AT DNA binding	nucleus
YDL177C_p	YDL177C	YDL177C	hom	Uncharacterized	1.2713253503224	0.101806463710952	no	609	0.0794466993978966	337	NA					Putative protein of unknown function; similar to the mouse IMPACT gene; YDL177C is not an essential gene	biological_process	molecular_function	cellular_component
YKR088C	YKR088C	TVP38	hom	Verified	1.27067509556825	0.101922129500702	no	610	0.102703053957374	417	NA	FT	VESICLE-MEDIATED TRANSPORT|CELL CYCLE|CYTOSKELETON ORGANIZATION	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; required for asymmetric localization of Kar9p during mitosis; GFP-fusion protein localizes to the cytoplasm in a punctate pattern	vesicle-mediated transport|mitotic spindle elongation	molecular_function	integral to membrane|integral to Golgi membrane|cytoplasm
YNL292W	YNL292W	PUS4	hom	Verified	1.26974738234629	0.102087314466349	no	611	0.106337075774054	419	NA	FT	RNA PROCESSING	NUCLEUS|MITOCHONDRION		Pseudouridine synthase, catalyzes only the formation of pseudouridine-55 (Psi55), a highly conserved tRNA modification, in mitochondrial and cytoplasmic tRNAs; PUS4 overexpression leads to translational derepression of GCN4 (Gcd- phenotype)	tRNA modification	pseudouridine synthase activity	mitochondrion|nucleus
YDR067C_p	YDR067C	OCA6	hom	Uncharacterized	1.26960792074853	0.102112163281624	no	612	0.122622316826091	445	NA					Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying positive-strand RNA virus replication; null mutation confers sensitivity to tunicamycin and DTT	biological_process	molecular_function	cytoplasm
YPL067C_p	YPL067C	YPL067C	hom	Uncharacterized	1.26937901357225	0.102152958758493	no	613	0.0921016871025831	302	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YPL067C is not an essential gene	biological_process	molecular_function	cytoplasm
YGR170W	YGR170W	PSD2	hom	Verified	1.26907645745805	0.102206898024421	no	614	0.103064235892253	392	NA	FT	LIPID METABOLISM	GOLGI APPARATUS		Phosphatidylserine decarboxylase of the Golgi and vacuolar membranes, converts phosphatidylserine to phosphatidylethanolamine	phosphatidylcholine biosynthetic process	phosphatidylserine decarboxylase activity	endosome
YNL147W	YNL147W	LSM7	hom	Verified	1.2683705935948	0.102332818955391	no	615	0.104369421864674	458	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress	nuclear-transcribed mRNA catabolic process|mRNA splicing, via spliceosome|maturation of SSU-rRNA	RNA binding	U6 snRNP|nucleolus|small nucleolar ribonucleoprotein complex|U4/U6 x U5 tri-snRNP complex|cytoplasm
YER066C-A_d	YER066C-A	YER066C-A	hom	Dubious	1.2665124901996	0.102664830283599	no	616	0.0852745641127261	296	NA					Dubious open reading frame unlikely to encode a protein, partially overlaps uncharacterized ORF YER067W	Unknown	Unknown	Unknown
YDR263C	YDR263C	DIN7	hom	Verified	1.26420136352875	0.103078880782872	no	617	0.110681565142186	418	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS|MITOCHONDRION		Mitochondrial nuclease functioning in DNA repair and replication, modulates the stability of the mitochondrial genome, induced by exposure to mutagens, also induced during meiosis at a time nearly coincident with commitment to recombination	DNA repair	nuclease activity	mitochondrion
YBR058C	YBR058C	UBP14	hom	Verified	1.2637325789253	0.103163013760605	no	618	0.104065918235587	404	NA	FT	KETONE METABOLISM|CARBOHYDRATE METABOLISM|PROTEOLYSIS	NUCLEUS		Ubiquitin-specific protease that specifically disassembles unanchored ubiquitin chains; involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; similar to human isopeptidase T	protein deubiquitination|negative regulation of gluconeogenesis|proteasomal ubiquitin-dependent protein catabolic process	ubiquitin-specific protease activity	cytoplasm
YKL220C	YKL220C	FRE2	hom	Verified	1.26342520178511	0.103218205932315	no	619	0.0772148258058523	292	NA	FT	ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|GEN. OF PRECURSOR METABOLITES AND ENERGY	PLASMA MEMBRANE		Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low iron levels but not by low copper levels	iron ion transport|copper ion import	ferric-chelate reductase activity	integral to membrane|plasma membrane
YHR061C	YHR061C	GIC1	hom	Verified	1.26334147828262	0.103233242911818	no	620	0.0956980201520599	344	NA	FT	CELL CYCLE|SIGNALING|CELL DIVISION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Protein involved in initiation of budding and cellular polarization; interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain; relocalizes from bud neck to nucleus upon DNA replication stress	regulation of exit from mitosis|establishment of cell polarity|axial cellular bud site selection|Rho protein signal transduction	Rho GTPase binding|Rho GTPase activator activity	incipient cellular bud site|actin cap|mating projection tip|cellular bud neck|cellular bud tip
YGL226C-A	YGL226C-A	OST5	hom	Verified	1.26285571275343	0.103320519172595	no	621	0.0999094759419559	397	NA	FT	CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Zeta subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins	protein N-linked glycosylation	dolichyl-diphosphooligosaccharide-protein glycotransferase activity	oligosaccharyltransferase complex
YDL116W	YDL116W	NUP84	hom	Verified	1.26212644463868	0.103451645483855	no	622	0.102481291542569	454	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|RIBOSOME BIOGENESIS|RESPONSE TO DNA DAMAGE|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport and NPC biogenesis; also plays roles in several processes that may require localization of genes or chromosomes at the nuclear periphery, including double-strand break repair, transcription and chromatin silencing; homologous to human NUP107	double-strand break repair|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|maintenance of chromatin silencing at telomere|nuclear pore distribution|telomere tethering at nuclear periphery|response to DNA damage stimulus|mRNA export from nucleus in response to heat stress|mRNA export from nucleus|positive regulation of transcription, DNA-dependent|protein import into nucleus|positive regulation of transcription from RNA polymerase II promoter|chromatin silencing at silent mating-type cassette	structural constituent of nuclear pore	integral to membrane|nuclear pore outer ring|nuclear pore
YJR054W	YJR054W	KCH1	hom	Verified	1.2619217153742	0.103488478606927	no	623	0.0864319443811232	311	NA					Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate	biological_process	molecular_function	integral to membrane|fungal-type vacuole
YKL018C-A_p	YKL018C-A	YKL018C-A	hom	Uncharacterized	1.26169865952052	0.103528619725047	no	624	0.0773565454067598	334	NA					Putative protein of unknown function; identified by homology; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	biological_process	molecular_function	cytoplasm
YKL091C	YKL091C	YKL091C	hom	Verified	1.25988368997943	0.103855661632275	no	625	0.10759353240013	397	NA	FT		NUCLEUS		Putative homolog of Sec14p, which is a phosphatidylinositol/phosphatidylcholine transfer protein involved in lipid metabolism; localizes to the nucleus; contains a CRAL/TRIO domain and binds several lipids in a large-scale study	biological_process	phosphatidylcholine binding|phosphatidylinositol transporter activity|phosphatidylinositol binding|phosphatidylcholine transporter activity	nucleus
YKL159C	YKL159C	RCN1	hom	Verified	1.25802227409502	0.104191850447112	no	626	0.0953502549942714	369	NA	FT	SIGNALING			Protein involved in calcineurin regulation during calcium signaling; has similarity to H. sapiens DSCR1 which is found in the Down Syndrome candidate region	calcium-mediated signaling	protein phosphatase 2B binding|calcium-dependent protein serine/threonine phosphatase regulator activity	cytoplasm
YOR029W_d	YOR029W	YOR029W	hom	Dubious	1.25744575636449	0.104296134676166	no	627	0.0729282891705185	254	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YMR086W	YMR086W	SEG1	hom	Verified	1.25741565375825	0.104301581906216	no	628	0.100216718526844	411	NA					Component of eisosome required for proper eisosome assembly; precedes Pil1p/Lsp1p during eisosome formation and controls eisosome length and shape; Seg1p-GFP diffusely distributed and forms heterogeneous patches at the plasma membrane in small buds, also found in medium and large buds; may interact with ribosomes, based on co-purification experiments; expression is repressed by cAMP; similar to A. gossypii SEG gene and to S. pombe Sle1p, important for generating eisosomes	biological_process	molecular_function	eisosome|ribosome|cytoplasm
YBR165W	YBR165W	UBS1	hom	Verified	1.25679938332234	0.104413144711223	no	629	0.0737218875302228	261	NA	FT	PROTEIN LOCALIZATION	NUCLEUS		Ubiquitin-conjugating enzyme suppressor that functions as a general positive regulator of Cdc34p activity; nuclear protein that may represent a link between nucleocytoplasmic transport and ubiquitin ligase activity	protein export from nucleus|protein ubiquitination	molecular_function	nucleus
YHL022C	YHL022C	SPO11	hom	Verified	1.25577698811564	0.104598418539674	no	630	0.0702867185457936	324	NA	FT	CELL CYCLE	NUCLEUS|CHROMOSOME		Meiosis-specific protein that initiates meiotic recombination by catalyzing the formation of double-strand breaks in DNA via a transesterification reaction; required for homologous chromosome pairing and synaptonemal complex formation	meiotic DNA double-strand break formation	endodeoxyribonuclease activity, producing 3'-phosphomonoesters	nuclear chromosome
YOR087W	YOR087W	YVC1	hom	Verified	1.25430711717949	0.10486519901195	no	631	0.0908169563843359	272	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Vacuolar cation channel, mediates release of Ca(2+) from the vacuole in response to hyperosmotic shock	cellular cation homeostasis	voltage-gated ion channel activity|calcium activated cation channel activity|sodium channel activity|calcium channel activity|potassium channel activity	fungal-type vacuole membrane|fungal-type vacuole
YLR289W	YLR289W	GUF1	hom	Verified	1.25370020221516	0.104975497208515	no	632	0.118071334429166	444	NA	FT	TRANSLATION|NUCLEOTIDE METABOLISM	MITOCHONDRION	RIBOSOME	Mitochondrial matrix GTPase that associates with mitochondrial ribosomes; important for translation under temperature and nutrient stress; may have a role in translational fidelity; similar to bacterial LepA elongation factor	positive regulation of translation	ribosome binding|GTPase activity	mitochondrion|mitochondrial ribosome|mitochondrial matrix
YLR346C_p	YLR346C	YLR346C	hom	Uncharacterized	1.25149427375653	0.105377100767674	no	633	0.0782412606738157	293	NA	FT		MITOCHONDRION		Putative protein of unknown function found in mitochondria; expression is regulated by transcription factors involved in pleiotropic drug resistance, Pdr1p and Yrr1p; YLR346C is not an essential gene	biological_process	molecular_function	mitochondrion
YLR353W	YLR353W	BUD8	hom	Verified	1.2508185253024	0.105500347242048	no	634	0.0715650298121206	265	NA	FT	CELL CYCLE|CELL DIVISION	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Protein involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the proximal pole	pseudohyphal growth|cellular bud site selection	molecular_function	incipient cellular bud site|plasma membrane|cellular bud tip
YER034W	YER034W	YER034W	hom	Verified	1.24611839524021	0.106360466191509	no	635	0.11714432023379	433	NA	FT		NUCLEUS		Protein of unknown function; non-essential gene; expression induced upon calcium shortage; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	nucleus|cytoplasm
YKL109W	YKL109W	HAP4	hom	Verified	1.24566576633211	0.106443563352323	no	636	0.107527874884969	402	NA	FT	TRANSCRIPTION FROM RNA POL II|OXIDATION-REDUCTION PROCESS|RESPONSE TO NUTRIENT LEVELS|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS		Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex	regulation of cellular respiration|carbon catabolite activation of transcription from RNA polymerase II promoter	RNA polymerase II activating transcription factor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II transcription factor binding transcription factor activity	CCAAT-binding factor complex
YMR103C_d	YMR103C	YMR103C	hom	Dubious	1.24478697759294	0.106605032106661	no	637	0.108624660454206	386	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YGR193C	YGR193C	PDX1	hom	Verified	1.24386615073836	0.106774414562166	no	638	0.0807734110107007	295	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Dihydrolipoamide dehydrogenase (E3)-binding protein (E3BP) of the mitochondrial pyruvate dehydrogenase (PDH) complex, plays a structural role in the complex by binding and positioning E3 to the dihydrolipoamide acetyltransferase (E2) core	acetyl-CoA biosynthetic process from pyruvate	structural molecule activity	mitochondrion|mitochondrial pyruvate dehydrogenase complex
YHR073W	YHR073W	OSH3	hom	Verified	1.243850193011	0.106777351633903	no	639	0.105893992179808	431	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION	ENDOPLASMIC RETICULUM		Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability	karyogamy involved in conjugation with cellular fusion|endocytosis|exocytosis|positive regulation of phosphatase activity|maintenance of cell polarity|pseudohyphal growth|sterol transport|invasive growth in response to glucose limitation	lipid binding|oxysterol binding|1-phosphatidylinositol binding|sterol transporter activity	cortical endoplasmic reticulum|cytoplasm
YPL230W	YPL230W	USV1	hom	Verified	1.24376541692325	0.106792955926736	no	640	0.0842640519920676	339	NA	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Putative transcription factor containing a C2H2 zinc finger; mutation affects transcriptional regulation of genes involved in growth on non-fermentable carbon sources, response to salt stress and cell wall biosynthesis; USV1 has a paralog, RGM1, that arose from the whole genome duplication	carbon catabolite activation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter in response to salt stress	sequence-specific DNA binding	nucleus
YDR239C	YDR239C	YDR239C	hom	Verified	1.24344824012126	0.106851351602999	no	641	0.108753847392624	388	NA					Protein of unknown function that may interact with ribosomes, based on co-purification experiments	biological_process	molecular_function	ribosome|cytoplasm
YBR040W	YBR040W	FIG1	hom	Verified	1.24120313757732	0.107265358030077	no	642	0.0949456276138631	383	NA	FT		SITE OF POLARIZED GROWTH		Integral membrane protein required for efficient mating; may participate in or regulate the low affinity Ca2+ influx system, which affects intracellular signaling and cell-cell fusion during mating	cell morphogenesis involved in conjugation with cellular fusion|cytogamy	molecular_function	fungal-type cell wall|integral to membrane|mating projection tip
YMR129W	YMR129W	POM152	hom	Verified	1.24087355616756	0.107326231459075	no	643	0.0638179773053063	225	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|CYTOSKELETON ORGANIZATION|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION	NUCLEAR PORE	Glycoprotein subunit of the transmembrane ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis and spindle pole body duplication; homologous to human NUP210	nucleocytoplasmic transport|nuclear pore organization|protein import into nucleus|spindle pole body duplication associated with nuclear envelope	protein anchor|structural constituent of nuclear pore	mitochondrion|integral to membrane|nuclear pore transmembrane ring|nuclear envelope lumen|nuclear pore
YAR029W_p	YAR029W	YAR029W	hom	Uncharacterized	1.23845198702922	0.107774257213179	no	644	0.0985560227313835	389	NA					Member of DUP240 gene family but contains no transmembrane domains; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern	biological_process	molecular_function	cytoplasm
YJL057C	YJL057C	IKS1	hom	Verified	1.23611669699232	0.108207594635616	no	645	0.105924277284734	390	NA	FT	PROTEIN PHOSPHORYLATION			Protein kinase of unknown cellular role; putative serine/threonine kinase; expression is induced during mild heat stress; deletion mutants are hypersensitive to copper sulphate and resistant to sorbate; interacts with an N-terminal fragment of Sst2p	protein phosphorylation	protein kinase activity	cellular_component
YLR054C	YLR054C	OSW2	hom	Verified	1.22977490467235	0.109390704078074	no	646	0.11436216085243	382	NA	FT	CELL WALL ORG/BIOGENESIS			Protein of unknown function proposed to be involved in the assembly of the spore wall	ascospore wall assembly	molecular_function	integral to membrane|prospore membrane|cytoplasm
YGR139W_d	YGR139W	YGR139W	hom	Dubious	1.22910190588367	0.109516800341415	no	647	0.0809467701395145	334	NA					Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDR276C	YDR276C	PMP3	hom	Verified	1.22632092198996	0.110038965552937	no	648	0.116328523011324	475	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Small plasma membrane protein related to a family of plant polypeptides that are overexpressed under high salt concentration or low temperature, not essential for viability, deletion causes hyperpolarization of the plasma membrane potential	regulation of membrane potential|cation transport	molecular_function	plasma membrane
YMR214W	YMR214W	SCJ1	hom	Verified	1.22629421153522	0.110043989427165	no	649	0.124855233123781	494	NA	FT	PROTEIN LOCALIZATION|PROTEOLYSIS	ENDOPLASMIC RETICULUM		One of several homologs of bacterial chaperone DnaJ, located in the ER lumen where it cooperates with Kar2p to mediate maturation of proteins	ER-associated protein catabolic process|protein folding in endoplasmic reticulum|response to unfolded protein	chaperone binding	endoplasmic reticulum lumen
YML054C-A_p	YML054C-A	YML054C-A	hom	Uncharacterized	1.22330972744819	0.110606367243963	no	650	0.0887544787099871	306	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YBR261C	YBR261C	TAE1	hom	Verified	1.22135670943745	0.110975495237477	no	651	0.081349398270104	332	NA	FT	TRANSLATION			AdoMet-dependent proline methyltransferase; catalyzes the dimethylation of ribosomal proteins Rpl12 and Rps25 at N-terminal proline residues; has a role in protein synthesis; fusion protein localizes to the cytoplasm	cytoplasmic translation|N-terminal peptidyl-proline dimethylation	N-terminal protein N-methyltransferase activity	cytosol|cytoplasm
YDL134C	YDL134C	PPH21	hom	Verified	1.22072610867052	0.111094869470868	no	652	0.0894403021894654	359	NA	FT	CELL CYCLE|TRANSLATION|CELL DIVISION|CYTOSKELETON ORGANIZATION			Catalytic subunit of protein phosphatase 2A (PP2A); functionally redundant with Pph22p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis; forms nuclear foci upon DNA replication stress; PPH21 has a paralog, PPH22, that arose from the whole genome duplication	actin filament organization|budding cell bud growth|protein dephosphorylation|G1/S transition of mitotic cell cycle|mitotic cell cycle spindle assembly checkpoint|regulation of translation	protein serine/threonine phosphatase activity	protein phosphatase type 2A complex
YDL078C	YDL078C	MDH3	hom	Verified	1.22005151831982	0.11122267280967	no	653	0.0840449478756304	311	NA	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM			Peroxisomal malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the glyoxylate cycle	glyoxylate cycle|fatty acid beta-oxidation|malate metabolic process|NADH regeneration	L-malate dehydrogenase activity|mRNA binding	peroxisomal matrix|peroxisome
YKR089C	YKR089C	TGL4	hom	Verified	1.21872103939013	0.111475044839599	no	654	0.112097411928378	420	NA	FT	LIPID METABOLISM|CELL DIVISION			Multifunctional triacylglycerol lipase, steryl ester hydrolase, and Ca2+-independent phospholipase A2; catalyzes acyl-CoA dependent acylation of LPA to PA; required with Tgl3p for timely bud formation; phosphorylated and activated by Cdc28p	phospholipid metabolic process|triglyceride catabolic process|triglyceride mobilization|cell budding	lysophosphatidic acid acyltransferase activity|triglyceride lipase activity|calcium-independent phospholipase A2 activity|sterol esterase activity	lipid particle
YGL117W_p	YGL117W	YGL117W	hom	Uncharacterized	1.21521994648265	0.112141107386332	no	655	0.168443547163748	616	NA	FF				Putative protein of unknown function	biological_process	molecular_function	cellular_component
YDR506C	YDR506C	GMC1	hom	Verified	1.21474510787226	0.11223166127961	no	656	0.0974647361676239	345	NA	FT	CELL CYCLE|ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS			Protein involved in meiotic progression; mutants are delayed in meiotic nuclear division and are defective in synaptonemal complex assembly; possible membrane-localized protein	meiosis|synaptonemal complex organization	molecular_function	cellular_component
YDR210W_p	YDR210W	YDR210W	hom	Uncharacterized	1.21219383121357	0.112719096149614	no	657	0.0712133983733215	252	NA	FT		PLASMA MEMBRANE		Predicted tail-anchored plasma membrane protein containing a conserved CYSTM module; related proteins in other organisms may be involved in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery	biological_process	molecular_function	cellular_component
YGR202C	YGR202C	PCT1	hom	Verified	1.21139797111466	0.112871458297871	no	658	0.0885139843093456	307	NA	FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|NUCLEUS|GOLGI APPARATUS		Cholinephosphate cytidylyltransferase; a rate-determining enzyme of the CDP-choline pathway for phosphatidylcholine synthesis, inhibited by Sec14p, activated upon lipid-binding; contains an element within the regulatory domain involved in both silencing and activation of enzymatic activity	phosphatidylcholine biosynthetic process|CDP-choline pathway	choline-phosphate cytidylyltransferase activity	nuclear envelope|Golgi apparatus|nucleus
YIL024C_p	YIL024C	YIL024C	hom	Uncharacterized	1.20851752490247	0.113424129496482	no	659	0.10222042913948	387	NA					Putative protein of unknown function; non-essential gene; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p	biological_process	molecular_function	cellular_component
YOR005C	YOR005C	DNL4	hom	Verified	1.20840161333843	0.113446409770712	no	660	0.0965299791607021	350	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CELL DIVISION	NUCLEUS|CHROMOSOME		DNA ligase required for nonhomologous end-joining (NHEJ), forms stable heterodimer with required cofactor Lif1p, interacts with Nej1p; involved in meiosis, not essential for vegetative growth	double-strand break repair via nonhomologous end joining|replicative cell aging	DNA ligase (ATP) activity	DNA ligase IV complex|nuclear chromatin
YOR352W	YOR352W	TFB6	hom	Verified	1.20774139852377	0.1135733743764	no	661	0.109341627037407	434	NA	FT		NUCLEUS		Subunit of TFIIH complex; facilities dissociation of the Ssl2p helices from TFIIH; expression levels regulated by Arg5,6p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus	biological_process	molecular_function	nucleus|holo TFIIH complex|cytoplasm
YGL109W_d	YGL109W	YGL109W	hom	Dubious	1.20716558705523	0.113684190224786	no	662	0.0795113512322367	291	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the uncharacterized gene YGL108C	Unknown	Unknown	Unknown
YIL072W	YIL072W	HOP1	hom	Verified	1.20704030194056	0.113708311753878	no	663	0.146222253837763	497	NA	FT	CELL CYCLE	NUCLEUS|CHROMOSOME		Meiosis-specific protein required for chromosome synapsis; displays Red1p dependent localization to the unsynapsed axial-lateral elements of the synaptonemal complex; required for chiasma formation; in vitro, displays the ability to promote intra- and intermolecular synapsis between double-stranded DNA molecules and to fold DNA into rigid protein?DNA filaments	synaptonemal complex assembly|meiotic recombination checkpoint|synapsis	four-way junction DNA binding	condensed nuclear chromosome|lateral element
YOR032C	YOR032C	HMS1	hom	Verified	1.20525124132661	0.114053163181823	no	664	0.127331935543187	479	NA	FT		NUCLEUS		Basic helix-loop-helix (bHLH) protein with similarity to myc-family transcription factors; overexpression confers hyperfilamentous growth and suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant	pseudohyphal growth	sequence-specific DNA binding transcription factor activity	cellular_component
YCL032W	YCL032W	STE50	hom	Verified	1.20485639246425	0.114129372762363	no	665	0.125725331532716	471	NA	FT	CELL CYCLE|SIGNALING			Protein involved in mating response, invasive/filamentous growth, and osmotolerance, acts as an adaptor that links G protein-associated Cdc42p-Ste20p complex to the effector Ste11p to modulate signal transduction	pheromone-dependent signal transduction involved in conjugation with cellular fusion|MAPK cascade involved in osmosensory signaling pathway|osmosensory signaling pathway via Sho1 osmosensor|signal transduction involved in filamentous growth|cellular response to heat	SAM domain binding|protein kinase regulator activity	cytoplasm
YGR106C	YGR106C	VOA1	hom	Verified	1.20365669102522	0.11436114904064	no	666	0.179165817921623	625	NA	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Endoplasmic reticulum protein that functions, together with other assembly factors, in assembly of the V0 sector of the vacuolar ATPase (V-ATPase); null mutation enhances the V-ATPase deficiency of a vma21 mutant impaired in ER retrieval	protein complex assembly	molecular_function	fungal-type vacuole membrane|endoplasmic reticulum membrane
YER048C	YER048C	CAJ1	hom	Verified	1.20152663671543	0.1147734901541	no	667	0.104254351183907	408	NA	FT		NUCLEUS		Nuclear type II J heat shock protein of the E. coli dnaJ family, contains a leucine zipper-like motif, binds to non-native substrates for presentation to Ssa3p, may function during protein translocation, assembly and disassembly	protein folding	chaperone binding	nucleus
YEL043W	YEL043W	YEL043W	hom	Verified	1.19988823774607	0.115091374348239	no	668	0.113433916500375	471	NA	FT		ENDOPLASMIC RETICULUM		Predicted cytoskeleton protein involved in intracellular signalling based on quantitative analysis of protein-protein interaction maps; may interact with ribosomes, based on co-purification studies; contains fibronectin type III domain fold	biological_process	molecular_function	ribosome|endoplasmic reticulum
YGR021W_p	YGR021W	YGR021W	hom	Uncharacterized	1.19956089438755	0.11515496087456	no	669	0.124970471100871	441	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YNL031C	YNL031C	HHT2	hom	Verified	1.19515728464859	0.116012792038374	no	670	0.0971784590379916	403	NA	FT	CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Histone H3, core histone protein required for chromatin assembly, part of heterochromatin-mediated telomeric and HM silencing; one of two identical histone H3 proteins (see HHT1); regulated by acetylation, methylation, and phosphorylation	chromatin assembly or disassembly|global genome nucleotide-excision repair|rRNA transcription|sexual sporulation resulting in formation of a cellular spore|mitotic cell cycle spindle assembly checkpoint	DNA binding	nuclear nucleosome
YMR234W	YMR234W	RNH1	hom	Verified	1.19430520518069	0.116179301128053	no	671	0.110815686065742	431	NA	FT	CELL WALL ORG/BIOGENESIS	NUCLEUS		Ribonuclease H1; able to bind double-stranded RNAs and RNA-DNA hybrids; associates with RNAse polymerase I; the homolog of mammalian RNAse HII (the S. cerevisiae homolog of mammalian RNAse HI is RNH201)	fungal-type cell wall organization|RNA catabolic process	ribonuclease H activity	intracellular|nucleus
YOR347C	YOR347C	PYK2	hom	Verified	1.19341056117806	0.116354310414002	no	672	0.0859979469701809	336	NA	FT	KETONE METABOLISM|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Pyruvate kinase; appears to be modulated by phosphorylation; transcription repressed by glucose, and Pyk2p may be active under low glycolytic flux; PYK2 has a paralog, CDC19, that arose from the whole genome duplication	pyruvate metabolic process	pyruvate kinase activity	cytosol|mitochondrion
YAR047C_d	YAR047C	YAR047C	hom	Dubious	1.19216932846732	0.116597428640557	no	673	0.10360791472414	393	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YMR310C_p	YMR310C	YMR310C	hom	Uncharacterized	1.19133399246775	0.116761247206061	no	674	0.124491179366202	449	NA	FT		NUCLEUS		Putative S-adenosylmethionine-dependent methyltransferase; predicted to be involved in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR310C is not an essential gene	biological_process	S-adenosylmethionine-dependent methyltransferase activity	nucleus
YHL009C	YHL009C	YAP3	hom	Verified	1.1911978520019	0.116787961303184	no	675	0.123806637622306	455	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Basic leucine zipper (bZIP) transcription factor	regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	nucleus
YDL184C	YDL184C	RPL41A	hom	Verified	1.18494792190592	0.118019019132057	no	676	0.102144340462629	337	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L41A; comprises only 25 amino acids; rpl41a rpl41b double null mutant is viable; homologous to mammalian ribosomal protein L41, no bacterial homolog; RPL41A has a paralog, RPL41B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YKR076W	YKR076W	ECM4	hom	Verified	1.18490036951916	0.118028420646937	no	677	0.123403255750371	455	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|CELL WALL ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS			Omega class glutathione transferase; not essential; similar to Ygr154cp; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	fungal-type cell wall organization|glutathione metabolic process	glutathione transferase activity	cytoplasm
YIL092W_p	YIL092W	YIL092W	hom	Uncharacterized	1.18352994762356	0.118299592469561	no	678	0.113492431736789	400	NA	FT		NUCLEUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus	biological_process	molecular_function	nucleus|cytoplasm
YDR403W	YDR403W	DIT1	hom	Verified	1.18320580169199	0.118363797112348	no	679	0.104270824556426	383	NA	FT	CELL WALL ORG/BIOGENESIS			Sporulation-specific enzyme required for spore wall maturation, involved in the production of a soluble LL-dityrosine-containing precursor of the spore wall; transcripts accumulate at the time of prospore enclosure	ascospore wall assembly	catalytic activity	cellular_component
YDL227C	YDL227C	HO	hom	Verified	1.18313398867247	0.118378024684126	no	680	0.0815291894615048	338	NA	FT		NUCLEUS		Site-specific endonuclease required for gene conversion at the MAT locus (homothallic switching) through the generation of a ds DNA break; expression restricted to mother cells in late G1 as controlled by Swi4p-Swi6p, Swi5p and Ash1p	mating type switching|gene conversion at mating-type locus, DNA double-strand break formation	endonuclease activity	nucleus
YPL187W	YPL187W	MF(ALPHA)1	hom	Verified	1.18153500086408	0.118695128802381	no	681	0.120915522555251	433	NA	FT	SIGNALING			Mating pheromone alpha-factor, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)2, although MF(ALPHA)1 produces most alpha-factor	pheromone-dependent signal transduction involved in conjugation with cellular fusion	mating pheromone activity	extracellular region
YOR266W	YOR266W	PNT1	hom	Verified	1.18117234551624	0.118767132404462	no	682	0.0898615376590721	324	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial integral inner membrane protein involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18p; deletion mutant sensitive to the anti-Pneumocystis carinii drug pentamidine	protein insertion into mitochondrial membrane from inner side	molecular_function	mitochondrion|integral to mitochondrial inner membrane
YHR106W	YHR106W	TRR2	hom	Verified	1.1810446392586	0.118792495256775	no	683	0.0921292262725925	353	NA	FT	OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS	MITOCHONDRION		Mitochondrial thioredoxin reductase; involved in protection against oxidative stress, required with Glr1p to maintain the redox state of Trx3p; contains active-site motif (CAVC) present in prokaryotic orthologs; binds NADPH and FAD; TRR2 has a paralog, TRR1, that arose from the whole genome duplication	cellular response to oxidative stress|cell redox homeostasis	thioredoxin-disulfide reductase activity	mitochondrion
YJL145W	YJL145W	SFH5	hom	Verified	1.17971735400041	0.119056324693943	no	684	0.0901105310201658	389	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Non-classical phosphatidylinositol transfer protein (PITP); exhibits PI- but not PC-transfer activity; localizes to the peripheral endoplasmic reticulum, cytosol and microsomes; similar to Sec14p; partially relocalizes to the plasma membrane upon DNA replication stress	Golgi to plasma membrane protein transport|phosphatidylinositol metabolic process|Unknown|regulation of exocytosis|phospholipid transport	phosphatidylinositol transporter activity|phosphatidylcholine transporter activity	cell periphery|cytosol|plasma membrane|cortical endoplasmic reticulum
YLR228C	YLR228C	ECM22	hom	Verified	1.17859339569071	0.119280061352112	no	685	0.105145860157267	381	NA	FT	TRANSCRIPTION FROM RNA POL II|LIPID METABOLISM	NUCLEUS		Sterol regulatory element binding protein; regulates transcription of sterol biosynthetic genes; contains Zn[2]-Cys[6] binuclear cluster; relocates from intracellular membranes to perinuclear foci on sterol depletion; ECM22 has a paralog, UPC2, that arose from the whole genome duplication	positive regulation of ergosterol biosynthetic process by positive regulation of transcription from RNA polymerase II promoter|positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus|membrane|perinuclear region of cytoplasm
YOL104C	YOL104C	NDJ1	hom	Verified	1.17785848874458	0.11942651327122	no	686	0.0991039413472781	397	NA	FT	CELL CYCLE	NUCLEUS|CHROMOSOME		Meiosis-specific telomere protein, required for bouquet formation, effective homolog pairing, ordered cross-over distribution, sister chromatid cohesion at meiotic telomeres, chromosomal segregation and telomere-led rapid prophase movement	meiotic telomere clustering|synapsis|attachment of telomeric heterochromatin to nuclear envelope|regulation of reciprocal meiotic recombination|reciprocal meiotic recombination	telomeric DNA binding	nuclear chromosome, telomeric region
YGR224W	YGR224W	AZR1	hom	Verified	1.17761671092632	0.119474722368272	no	687	0.102427126460058	431	NA	FT		PLASMA MEMBRANE		Plasma membrane transporter of the major facilitator superfamily, involved in resistance to azole drugs such as ketoconazole and fluconazole	azole transport	azole transporter activity	integral to membrane|plasma membrane
YBL022C	YBL022C	PIM1	hom	Verified	1.1771124658808	0.119575310083504	no	688	0.163860658131942	587	NA	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS|MITOCHONDRION ORGANIZATION|RESPONSE TO OXIDATIVE STRESS	MITOCHONDRION		ATP-dependent Lon protease, involved in degradation of misfolded proteins in mitochondria; required for biogenesis and maintenance of mitochondria	chaperone-mediated protein complex assembly|misfolded or incompletely synthesized protein catabolic process	ATP-dependent peptidase activity	mitochondrion|mitochondrial matrix
YNL044W	YNL044W	YIP3	hom	Verified	1.17593704788619	0.119810016476276	no	689	0.111788937638724	409	NA	FT	VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Protein localized to COPII vesicles, proposed to be involved in ER to Golgi transport; interacts with members of the Rab GTPase family and Yip1p; also interacts with Rtn1p	ER to Golgi vesicle-mediated transport	molecular_function	Golgi apparatus|endoplasmic reticulum|ER to Golgi transport vesicle
YPL244C	YPL244C	HUT1	hom	Verified	1.17210425095094	0.120577601721271	no	690	0.117450967106398	451	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein with a role in UDP-galactose transport to the Golgi lumen, has similarity to human UDP-galactose transporter UGTrel1, exhibits a genetic interaction with S. cerevisiae ERO1	UDP-galactose transport|UDP-glucose transport	UDP-galactose transmembrane transporter activity	integral to membrane
YKL002W	YKL002W	DID4	hom	Verified	1.17076035019271	0.120847559711503	no	691	0.13425602551468	505	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|PROTEOLYSIS|VACUOLAR TRANSPORT			Class E Vps protein of the ESCRT-III complex, required for sorting of integral membrane proteins into lumenal vesicles of multivesicular bodies, and for delivery of newly synthesized vacuolar enzymes to the vacuole, involved in endocytosis	protein retention in Golgi apparatus|intralumenal vesicle formation|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|late endosome to vacuole transport	molecular_function	ESCRT III complex|cytoplasm
YEL048C	YEL048C	TCA17	hom	Verified	1.16821474631504	0.121360076866787	no	692	0.105828597819436	375	NA	FT	VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS	GOLGI APPARATUS		Subunit of TRAPPII, a multimeric GEF involved in intra-Golgi and endosome-to-Golgi transport; promotes association of TRAPPII-specific subunits with the core complex; sedlin related; human Sedlin mutations cause SEDT, a skeletal disorder	early endosome to Golgi transport|protein complex assembly	molecular_function	TRAPP complex|Golgi apparatus|clathrin-coated vesicle
YNL289W	YNL289W	PCL1	hom	Verified	1.16777669440454	0.121448425602512	no	693	0.12757721207968	452	NA	FT	CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Cyclin, interacts with cyclin-dependent kinase Pho85p; member of the Pcl1,2-like subfamily, involved in the regulation of polarized growth and morphogenesis and progression through the cell cycle; is ubiquitinated by Dma1p; phosphorylation by Pho85p targets it for degradation; localizes to sites of polarized cell growth	regulation of establishment or maintenance of cell polarity|G1 phase of mitotic cell cycle|regulation of cyclin-dependent protein kinase activity|septin ring organization|positive regulation of macroautophagy	cyclin-dependent protein kinase regulator activity	cyclin-dependent protein kinase holoenzyme complex|incipient cellular bud site|nucleus
YIL156W	YIL156W	UBP7	hom	Verified	1.16702683946652	0.121599765427435	no	694	0.124810129271951	422	NA	FT	PROTEOLYSIS			Ubiquitin-specific protease that cleaves ubiquitin-protein fusions	protein deubiquitination	ubiquitin-specific protease activity	cytoplasm
YNL142W	YNL142W	MEP2	hom	Verified	1.16685374911248	0.121634718290279	no	695	0.112063190865276	391	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Ammonium permease involved in regulation of pseudohyphal growth; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation	nitrogen utilization|ammonium transport|pseudohyphal growth	ammonium transmembrane transporter activity	integral to membrane|plasma membrane
YER109C	YER109C	FLO8	hom	Verified	1.16648176191223	0.121709859120475	no	696	0.0989285814520991	358	NA	FT	TRANSCRIPTION FROM RNA POL II|CARBOHYDRATE METABOLISM	NUCLEUS		Transcription factor required for flocculation, diploid filamentous growth, and haploid invasive growth; genome reference strain S288C and most laboratory strains have a mutation in this gene	biofilm formation|Unknown|positive regulation of starch catabolic process by positive regulation of transcription from RNA polymerase II promoter|positive regulation of invasive growth in response to glucose limitation by positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus|cytoplasm
YJL181W_p	YJL181W	YJL181W	hom	Uncharacterized	1.16629991083956	0.121746604619615	no	697	0.084612250772211	322	NA					Putative protein of unknown function; expression is cell-cycle regulated as shown by microarray analysis; potential regulatory target of Mbp1p, which binds to the YJL181W promoter region; YJL181W has a paralog, YJR030C, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YDR329C	YDR329C	PEX3	hom	Verified	1.16369949846219	0.122272906376028	no	698	0.127710311081966	448	NA	FT	PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION	ENDOPLASMIC RETICULUM		Peroxisomal membrane protein (PMP) required for proper localization and stability of PMPs; anchors peroxisome retention factor Inp1p at the peroxisomal membrane; interacts with Pex19p	protein import into peroxisome membrane|peroxisome inheritance|ER-dependent peroxisome organization	protein binding	peroxisomal membrane|endoplasmic reticulum
YOL057W	YOL057W	YOL057W	hom	Verified	1.16314613557529	0.122385108188517	no	699	0.107815791828552	376	NA	FT	PROTEOLYSIS	NUCLEUS		Dipeptidyl-peptidase III; cleaves dipeptides from the amino terminus of target proteins; highly active on synthetic substrate Arg-Arg-2-naphthylamide; mammalian ortholog may be a biomarker for some cancers	proteolysis	dipeptidyl-peptidase activity	nucleus|cytoplasm
YFR018C_p	YFR018C	YFR018C	hom	Uncharacterized	1.1621094887285	0.122595496802893	no	700	0.112813969227878	395	NA	FT	PROTEOLYSIS			Putative protein of unknown function	biological_process	molecular_function	cellular_component
YNL004W	YNL004W	HRB1	hom	Verified	1.16169531968521	0.122679623762229	no	701	0.12555675927356	451	NA	FT	RNA LOCALIZATION	NUCLEUS		Poly(A+) RNA-binding protein; involved in the export of mRNAs from the nucleus to the cytoplasm; similar to Npl3p; HRB1 has a paralog, GBP2, that arose from the whole genome duplication	poly(A)+ mRNA export from nucleus	RNA binding	integral to membrane|nucleus|cytoplasm
YOR292C_p	YOR292C	YOR292C	hom	Uncharacterized	1.16125678958984	0.122768743122587	no	702	0.102114976500994	387	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YOR292C is not an essential gene	biological_process	molecular_function	integral to membrane|fungal-type vacuole
YOR338W_p	YOR338W	YOR338W	hom	Uncharacterized	1.16121317550038	0.122777608986398	no	703	0.101680814328244	420	NA	FT	TRANSCRIPTION FROM RNA POL II			Putative protein of unknown function; YOR338W transcription is regulated by Azf1p and its transcript is a specific target of the G protein effector Scp160p; identified as being required for sporulation in a high-throughput mutant screen; YOR338W has a paralog, FUN19, that arose from the whole genome duplication	ascospore formation|positive regulation of transcription from RNA polymerase II promoter	molecular_function	cellular_component
YOL141W	YOL141W	PPM2	hom	Verified	1.16013951567518	0.122996003949843	no	704	0.0857650534143364	291	NA	FT	RNA PROCESSING	MITOCHONDRION		AdoMet-dependent tRNA methyltransferase also involved in methoxycarbonylation; required for the synthesis of wybutosine (yW), a modified guanosine found at the 3'-position adjacent to the anticodon of phe-tRNA; similarity to Ppm1p	tRNA methylation|wybutosine biosynthetic process	tRNA methyltransferase activity	mitochondrion|cytoplasm
YMR175W-A_p	YMR175W-A	YMR175W-A	hom	Uncharacterized	1.15911820141721	0.123204003829698	no	705	0.111250746649832	399	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YER153C	YER153C	PET122	hom	Verified	1.15834679734889	0.123361270561494	no	706	0.117102696499506	466	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet494p; located in the mitochondrial inner membrane	positive regulation of mitochondrial translation|mitochondrial respiratory chain complex IV biogenesis	translation initiation factor activity	mitochondrion|mitochondrial inner membrane|integral to mitochondrial inner membrane
YPL155C	YPL155C	KIP2	hom	Verified	1.1579046922922	0.123451466228458	no	707	0.0884079493529661	358	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION	MITOCHONDRION|CYTOSKELETON		Kinesin-related motor protein involved in mitotic spindle positioning, stabilizes microtubules by targeting Bik1p to the plus end; Kip2p levels are controlled during the cell cycle	nuclear migration along microtubule|mitotic anaphase B|negative regulation of microtubule depolymerization	microtubule motor activity	mitochondrion|kinesin complex|cytoplasmic microtubule
YOR021C	YOR021C	SFM1	hom	Verified	1.15686487139682	0.123663786420864	no	708	0.111343243977943	427	NA					SPOUT methyltransferase; catalyzes omega-monomethylation of Rps3p on Arg-146; not an essential gene; predicted to be involved in rRNA processing and ribosome biogenesis and in biopolymer catabolism	peptidyl-arginine methylation	protein-arginine omega-N monomethyltransferase activity	cellular_component
YLR282C_d	YLR282C	YLR282C	hom	Dubious	1.15632618311487	0.123773881234979	no	709	0.108863673768978	404	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion mutation confers an increase in Ty1 transposition	Unknown	Unknown	Unknown
YML048W	YML048W	GSF2	hom	Verified	1.15625078774159	0.123789295692159	no	710	0.159956630724521	603	NA	FF|FT	PROTEIN LOCALIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION		ER localized integral membrane protein that may promote secretion of certain hexose transporters, including Gal2p; involved in glucose-dependent repression	protein folding|protein localization to cell surface	unfolded protein binding	mitochondrial outer membrane|integral to endoplasmic reticulum membrane|cytoplasm
YNR045W	YNR045W	PET494	hom	Verified	1.15604111614996	0.12383216976127	no	711	0.104094384759017	385	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet122p; located in the mitochondrial inner membrane	mitochondrial respiratory chain complex IV biogenesis|positive regulation of mitochondrial translation	translation regulator activity	mitochondrion|mitochondrial inner membrane
YLR258W	YLR258W	GSY2	hom	Verified	1.15580422519712	0.123880622205131	no	712	0.126083650637023	459	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY			Glycogen synthase; expression induced by glucose limitation, nitrogen starvation, heat shock, and stationary phase; activity regulated by cAMP-dependent, Snf1p and Pho85p kinases as well as by the Gac1p-Glc7p phosphatase; GSY2 has a paralog, GSY1, that arose from the whole genome duplication; relocalizes from cytoplasm to plasma membrane upon DNA replication stress	glycogen biosynthetic process	glycogen (starch) synthase activity	cytoplasm
YER149C	YER149C	PEA2	hom	Verified	1.15572088687785	0.123897670946527	no	713	0.111828143248178	421	NA	FT	CELL CYCLE|SIGNALING|CELL DIVISION|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Coiled-coil polarisome protein required for polarized morphogenesis, cell fusion, and low affinity Ca2+ influx; forms polarisome complex with Bni1p, Bud6p, and Spa2p; localizes to sites of polarized growth	bipolar cellular bud site selection|regulation of initiation of mating projection growth|regulation of termination of mating projection growth|actin filament organization|pseudohyphal growth|establishment of cell polarity|filamentous growth|Rho protein signal transduction	cytoskeletal regulatory protein binding	polarisome|actin cap|mating projection tip
YDR097C	YDR097C	MSH6	hom	Verified	1.15511155913359	0.124022372640707	no	714	0.0957824586362722	366	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Protein required for mismatch repair in mitosis and meiosis, forms a complex with Msh2p to repair both single-base & insertion-deletion mispairs; also involved in interstrand cross-link repair; potentially phosphorylated by Cdc28p	mismatch repair|meiotic mismatch repair	guanine/thymine mispair binding|four-way junction DNA binding|ATPase activity|single base insertion or deletion binding|ATP binding	MutSalpha complex|nucleus
YNR015W	YNR015W	SMM1	hom	Verified	1.15423854751423	0.124201191458734	no	715	0.096201652844635	381	NA	FT	RNA PROCESSING|OXIDATION-REDUCTION PROCESS	NUCLEUS		Dihydrouridine synthase, member of a family of dihydrouridine synthases including Dus1p, Smm1p, Dus3p, and Dus4p; modifies uridine residues at position 20 of cytoplasmic tRNAs	tRNA processing|tRNA modification	tRNA dihydrouridine synthase activity	nucleus|cytoplasm
YMR183C	YMR183C	SSO2	hom	Verified	1.15349654839761	0.124353316735086	no	716	0.109822927942326	441	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION	ENDOPLASMIC RETICULUM|PLASMA MEMBRANE		Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane; syntaxin homolog that is functionally redundant with Sso1p	Golgi to plasma membrane transport|ascospore-type prospore assembly|vesicle fusion	phosphatidic acid binding|SNAP receptor activity	endoplasmic reticulum|plasma membrane|prospore membrane|cytoplasm
YJR150C	YJR150C	DAN1	hom	Verified	1.1534134751177	0.124370356595736	no	717	0.0985180854092467	395	NA					Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth	sterol transport	molecular_function	fungal-type cell wall
YCR068W	YCR068W	ATG15	hom	Verified	1.15304834691911	0.124445270478387	no	718	0.148578824616132	552	NA	FT	LIPID METABOLISM|MEMBRANE ORGANIZATION|VACUOLAR PROTEIN PROCESSING	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Lipase required for intravacuolar lysis of autophagic bodies and Cvt bodies; targeted to intravacuolar vesicles during autophagy via the multivesicular body (MVB) pathway	membrane disassembly|autophagy|piecemeal microautophagy of nucleus|vacuolar protein processing|multivesicular body membrane disassembly	lipase activity	integral to membrane|vacuolar lumen
YPL203W	YPL203W	TPK2	hom	Verified	1.14969508521124	0.125134739660587	no	719	0.121516472038491	488	NA	FT	SIGNALING|PROTEIN PHOSPHORYLATION	NUCLEUS		cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk3p; localizes to P-bodies during stationary phase	protein phosphorylation|Ras protein signal transduction|invasive growth in response to glucose limitation	cAMP-dependent protein kinase activity|protein kinase activity	nucleus|cAMP-dependent protein kinase complex
YMR318C	YMR318C	ADH6	hom	Verified	1.14934082127918	0.12520773589907	no	720	0.120392527097633	427	NA	FT	OXIDATION-REDUCTION PROCESS			NADPH-dependent medium chain alcohol dehydrogenase; has broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance; protein abundance increases in response to DNA replication stress	cellular aldehyde metabolic process|furaldehyde metabolic process|alcohol metabolic process	hydroxymethylfurfural reductase (NADH) activity|hydroxymethylfurfural reductase (NADPH) activity|alcohol dehydrogenase (NADP+) activity	cellular_component
YOR061W	YOR061W	CKA2	hom	Verified	1.14901761211494	0.125274359222179	no	721	0.147027318253062	590	NA	FF|FT	RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION	NUCLEUS		Alpha' catalytic subunit of casein kinase 2 (CK2); CK2 is a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases; protein abundance increases in response to DNA replication stress; regulates Fkh1p-mediated donor preference during mating-type switching	regulation of transcription from RNA polymerase I promoter|chronological cell aging|protein phosphorylation|regulation of transcription from RNA polymerase III promoter|response to DNA damage stimulus	protein serine/threonine kinase activity	protein kinase CK2 complex|UTP-C complex
YAR035W	YAR035W	YAT1	hom	Verified	1.14883670451314	0.125311660630158	no	722	0.110422371987604	425	NA	FT	KETONE METABOLISM|LIPID METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		Outer mitochondrial carnitine acetyltransferase, minor ethanol-inducible enzyme involved in transport of activated acyl groups from the cytoplasm into the mitochondrial matrix; phosphorylated	carnitine metabolic process|alcohol metabolic process	carnitine O-acetyltransferase activity	mitochondrion
YDR006C	YDR006C	SOK1	hom	Verified	1.14807223290249	0.125469372937133	no	723	0.111430103490438	375	NA	FT	SIGNALING	NUCLEUS		Protein whose overexpression suppresses the growth defect of mutants lacking protein kinase A activity; involved in cAMP-mediated signaling; localized to the nucleus; similar to the mouse testis-specific protein PBS13	cAMP-mediated signaling	molecular_function	nucleus
YBR276C	YBR276C	PPS1	hom	Verified	1.14676672417236	0.125739022670973	no	724	0.0873244213967928	316	NA	FT	CELL CYCLE|SIGNALING|PROTEIN PHOSPHORYLATION	NUCLEUS		Protein phosphatase with specificity for serine, threonine, and tyrosine residues; has a role in the DNA synthesis phase of the cell cycle	inactivation of MAPK activity|protein dephosphorylation|regulation of S phase of mitotic cell cycle	protein tyrosine/serine/threonine phosphatase activity	cellular_component
YOR283W	YOR283W	YOR283W	hom	Verified	1.14557635914636	0.125985241863926	no	725	0.121417859267869	427	NA	FT	CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS		Phosphatase with a broad substrate specificity and some similarity to GPM1/YKL152C, a phosphoglycerate mutase; YOR283W is not an essential gene	dephosphorylation	phosphatase activity	nucleus|cytoplasm
YMR010W_p	YMR010W	YMR010W	hom	Uncharacterized	1.14511093740108	0.126081602656893	no	726	0.122023260341432	435	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR010W is not an essential gene; YMR010W mRNA is transcribed with ADI1	biological_process	molecular_function	integral to membrane|cytoplasm
YIL076W	YIL076W	SEC28	hom	Verified	1.14256724814338	0.126609155155974	no	727	0.120173866336204	466	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Epsilon-COP subunit of the coatomer; regulates retrograde Golgi-to-ER protein traffic; stabilizes Cop1p, the alpha-COP and the coatomer complex; non-essential for cell growth; protein abundance increases in response to DNA replication stress	late endosome to vacuole transport via multivesicular body sorting pathway|ER to Golgi vesicle-mediated transport|vesicle coating	molecular_function	endosome|COPI vesicle coat
YOL043C	YOL043C	NTG2	hom	Verified	1.14217561942453	0.126690513993821	no	728	0.097062262340488	337	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair, localizes to the nucleus; sumoylated; NTG2 has a paralog, NTG1, that arose from the whole genome duplication	base-excision repair|base-excision repair, AP site formation	oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity|DNA-(apurinic or apyrimidinic site) lyase activity	nucleus
YKL151C	YKL151C	YKL151C	hom	Verified	1.14210287749843	0.126705629760557	no	729	0.0954713436435512	340	NA	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM			NADHX dehydratase; converts (S)-NADHX to NADH in an ATP-dependent manner; homologous to Carkd in mammals, and the C-terminal domain of YjeF in E.coli; enzyme is widespread in eukaryotes, prokaryotes and archaea; YKL151C promoter contains STREs (stress response elements) and expression is induced by heat shock or methyl methanesulfonate; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress	nicotinamide nucleotide metabolic process	ATP-dependent NAD(P)H-hydrate dehydratase activity	cytoplasm
YOR379C_d	YOR379C	YOR379C	hom	Dubious	1.14086860858895	0.126962302204012	no	730	0.118594603967293	445	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR378W	Unknown	Unknown	Unknown
YGR124W	YGR124W	ASN2	hom	Verified	1.1399227959879	0.127159233467664	no	731	0.122744653157489	449	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Asparagine synthetase; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway; ASN2 has a paralog, ASN1, that arose from the whole genome duplication	asparagine biosynthetic process	asparagine synthase (glutamine-hydrolyzing) activity	cytoplasm
YIL111W	YIL111W	COX5B	hom	Verified	1.13839752018202	0.127477264540641	no	732	0.116817716094212	389	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Subunit Vb of cytochrome c oxidase; cytochrome c oxidase is the terminal member of the mitochondrial inner membrane electron transport chain; Cox5Bp is predominantly expressed during anaerobic growth while its isoform Va (Cox5Ap) is expressed during aerobic growth; COX5B has a paralog, COX5A, that arose from the whole genome duplication	mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity|nitrite reductase (NO-forming) activity	mitochondrion|integral to membrane|mitochondrial respiratory chain complex IV
YML083C	YML083C	YML083C	hom	Verified	1.13811301637394	0.127536646803611	no	733	0.101598328843539	352	NA					Protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; strong increase in transcript abundance during anaerobic growth compared to aerobic growth; cells deleted for YML083C do not exhibit growth defects in anerobic or anaerobic conditions	biological_process	molecular_function	cellular_component
YFR021W	YFR021W	ATG18	hom	Verified	1.13671394666745	0.127828943560273	no	734	0.13466839265585	483	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS|PEROXISOME ORGANIZATION|VACUOLAR PROTEIN PROCESSING			Phosphoinositide binding protein; required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; binds both phosphatidylinositol (3,5)-bisphosphate and phosphatidylinositol 3-phosphate; WD-40 repeat protein; relocalizes from vacuole to cytoplasm upon DNA replication stress; has 4 mammalian homologs WIPI1, WIPI2, WIPI3 and WIPI4/WDR45; mutations in human WDR45 cause static encephalopathy of childhood with neurodegeneration in adulthood	piecemeal microautophagy of nucleus|peroxisome degradation|vacuolar protein processing|macroautophagy|late endosome to vacuole transport|CVT pathway	ubiquitin binding|phosphatidylinositol binding	cytosol|endosome|fungal-type vacuole membrane|PAS complex|pre-autophagosomal structure
YGL053W	YGL053W	PRM8	hom	Verified	1.13619884746984	0.127936676393689	no	735	0.115429746086362	407	NA	FT	VESICLE-MEDIATED TRANSPORT	ENDOPLASMIC RETICULUM|PLASMA MEMBRANE		Pheromone-regulated protein with 2 predicted transmembrane segments and an FF sequence, a motif involved in COPII binding; forms a complex with Prp9p in the ER; member of DUP240 gene family	biological_process	molecular_function	integral to membrane|endoplasmic reticulum|plasma membrane
YKL066W_d	YKL066W	YKL066W	hom	Dubious	1.13605640045384	0.12796648027383	no	736	0.0821522432698187	304	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related <i>Saccharomyces</i> species; partially overlaps the verified gene YNK1	Unknown	Unknown	Unknown
YBR085W	YBR085W	AAC3	hom	Verified	1.13311714493339	0.128582531181077	no	737	0.111469807178171	425	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Mitochondrial inner membrane ADP/ATP translocator; exchanges cytosolic ADP for mitochondrially synthesized ATP; expressed under anaerobic conditions; similar to Aac1p; has roles in maintenance of viability and in respiration; AAC3 has a paralog, PET9, that arose from the whole genome duplication	heme biosynthetic process|heme transport|anaerobic respiration|transmembrane transport	ATP:ADP antiporter activity	mitochondrion|integral to membrane|mitochondrial inner membrane
YBR044C	YBR044C	TCM62	hom	Verified	1.13276573601028	0.12865632196782	no	738	0.0751159745490566	338	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Protein involved in the assembly of the mitochondrial succinate dehydrogenase complex; putative chaperone	mitochondrial respiratory chain complex II assembly	unfolded protein binding	mitochondrion|mitochondrial inner membrane
YBR161W	YBR161W	CSH1	hom	Verified	1.1320295110452	0.128811013808818	no	739	0.104934323696287	437	NA	FT	LIPID METABOLISM			Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit; forms a complex with regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Sur1p; CSH1 has a paralog, SUR1, that arose from the whole genome duplication	glycosphingolipid biosynthetic process|sphingolipid biosynthetic process	mannosyltransferase activity|transferase activity, transferring glycosyl groups	integral to membrane|fungal-type vacuole
YAL017W	YAL017W	PSK1	hom	Verified	1.13200329703139	0.128816524141744	no	740	0.115388653906237	381	NA	FT	SIGNALING|TRANSLATION|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION|GEN. OF PRECURSOR METABOLITES AND ENERGY			PAS domain-containing serine/threonine protein kinase; coordinately regulates protein synthesis and carbohydrate metabolism and storage in response to a unknown metabolite that reflects nutritional status; PSK1 has a paralog, PSK2, that arose from the whole genome duplication	regulation of (1->6)-beta-D-glucan biosynthetic process|negative regulation of glycogen biosynthetic process|protein phosphorylation	protein serine/threonine kinase activity|protein kinase activity	cytoplasm
YIL069C	YIL069C	RPS24B	hom	Verified	1.13041769912289	0.129150129837891	no	741	0.106820501475655	432	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION	NUCLEUS	RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S24, no bacterial homolog; RPS24B has a paralog, RPS24A, that arose from the whole genome duplication	cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome	cytosolic small ribosomal subunit
YPL166W	YPL166W	ATG29	hom	Verified	1.12960320670562	0.129321729596601	no	742	0.122762251420236	449	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|RESPONSE TO NUTRIENT LEVELS			Autophagy-specific protein; required for recruiting other ATG proteins to the pre-autophagosomal structure (PAS); interacts with Atg17p and localizas to the PAS in a manner interdependent with Atg17p and Cis1p; not conserved; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress	mitochondrion degradation|piecemeal microautophagy of nucleus|macroautophagy	molecular_function	pre-autophagosomal structure|cytoplasm
YIL057C	YIL057C	RGI2	hom	Verified	1.12801195370697	0.12965743542088	no	743	0.145642948923602	531	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY			Protein of unknown function involved in energy metabolism under respiratory conditions; expression induced under carbon limitation and repressed under high glucose	energy reserve metabolic process	molecular_function	cytoplasm
YIL011W	YIL011W	TIR3	hom	Verified	1.12631552518626	0.130015994306249	no	744	0.108940288639743	417	NA					Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expressed under anaerobic conditions and required for anaerobic growth	biological_process	molecular_function	fungal-type cell wall
YJL192C	YJL192C	SOP4	hom	Verified	1.12541340575888	0.130206946479092	no	745	0.186155877973276	648	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		ER-membrane protein; suppressor of pma1-7, deletion of SOP4 slows down the export of wild-type Pma1p and Pma1-7 from the ER	ER to Golgi vesicle-mediated transport	molecular_function	integral to membrane|endoplasmic reticulum
YDR185C	YDR185C	UPS3	hom	Verified	1.12488877910872	0.13031808372048	no	746	0.131035890918379	478	NA	FT	MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial protein of unknown function; similar to Ups1p and Ups2p which are involved in regulation of mitochondrial cardiolipin and phosphatidylethanolamine levels; null is viable but interacts synthetically with ups1 and ups2 mutations	mitochondrion morphogenesis	molecular_function	extrinsic to mitochondrial inner membrane|mitochondrion|mitochondrial intermembrane space
YOR285W	YOR285W	RDL1	hom	Verified	1.12374872852844	0.130559818956231	no	747	0.118594503187768	431	NA	FT		ENDOPLASMIC RETICULUM|MITOCHONDRION		Protein of unknown function containing a rhodanese-like domain; localized to the mitochondrial outer membrane; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	mitochondrial outer membrane|mitochondrion|endoplasmic reticulum
YIL152W_p	YIL152W	YIL152W	hom	Uncharacterized	1.1230882510225	0.130700007742452	no	748	0.105799987636455	352	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YFL018C	YFL018C	LPD1	hom	Verified	1.1212840219027	0.131083492294547	no	749	0.132788887442607	510	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS	MITOCHONDRION		Dihydrolipoamide dehydrogenase, the lipoamide dehydrogenase component (E3) of the pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase multi-enzyme complexes	L-serine biosynthetic process|2-oxoglutarate metabolic process|leucine catabolic process|glycine catabolic process|isoleucine catabolic process|pyruvate metabolic process|valine catabolic process|hydrogen peroxide metabolic process	glycine dehydrogenase (decarboxylating) activity|pyruvate dehydrogenase activity|oxoglutarate dehydrogenase (succinyl-transferring) activity|dihydrolipoyl dehydrogenase activity	mitochondrial nucleoid|mitochondrion|glycine cleavage complex|mitochondrial oxoglutarate dehydrogenase complex
YML086C	YML086C	ALO1	hom	Verified	1.11874146731204	0.131625224536173	no	750	0.106445612800381	398	NA	FT	OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS	MITOCHONDRION		D-Arabinono-1,4-lactone oxidase, catalyzes the final step in biosynthesis of dehydro-D-arabinono-1,4-lactone, which is protective against oxidative stress	cellular response to oxidative stress|dehydro-D-arabinono-1,4-lactone biosynthetic process	D-arabinono-1,4-lactone oxidase activity	mitochondrial outer membrane|mitochondrion|integral to mitochondrial outer membrane
YLR205C	YLR205C	HMX1	hom	Verified	1.11625244476988	0.132157045642601	no	751	0.102043244173903	372	NA	FT	ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM		ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants	response to oxidative stress|cellular iron ion homeostasis|heme catabolic process	heme oxygenase (decyclizing) activity	endoplasmic reticulum|membrane|nuclear outer membrane
YLL006W-A_p	YLL006W-A	YLL006W-A	hom	Uncharacterized	1.11223809692026	0.133017895882484	no	752	0.10334481219049	387	NA					Putative protein of unknown function; identified by fungal homology and RT-PCR	biological_process	molecular_function	cellular_component
YDR122W	YDR122W	KIN1	hom	Verified	1.11072217691899	0.133343976693482	no	753	0.110100748280979	373	NA	FT	VESICLE-MEDIATED TRANSPORT|PROTEIN PHOSPHORYLATION	PLASMA MEMBRANE		Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p	protein autophosphorylation|exocytosis|protein phosphorylation	protein serine/threonine kinase activity|protein kinase activity	internal side of plasma membrane|plasma membrane
YDR116C	YDR116C	MRPL1	hom	Verified	1.1069904090265	0.134149037513141	no	754	0.12579426217265	444	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YCR090C_p	YCR090C	YCR090C	hom	Uncharacterized	1.1069186598661	0.134164548730284	no	755	0.0957816689306215	404	NA	FT		NUCLEUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YCR090C is not an essential gene	biological_process	molecular_function	nucleus|cytoplasm
YML120C	YML120C	NDI1	hom	Verified	1.10648259233171	0.134258847246749	no	756	0.105947791074231	391	NA	FT	OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		NADH:ubiquinone oxidoreductase; transfers electrons from NADH to ubiquinone in the respiratory chain but does not pump protons, in contrast to the higher eukaryotic multisubunit respiratory complex I; phosphorylated; involved in Mn and H2O2 induced apoptosis; upon apoptotic stress, Ndip is activated in the mitochondria by N-terminal cleavage, and the truncated protein translocates to the cytoplasm to induce apoptosis; homolog of human AMID	mitochondrial electron transport, NADH to ubiquinone|NADH oxidation|chronological cell aging|positive regulation of apoptotic process	NADH dehydrogenase (ubiquinone) activity	mitochondrion|mitochondrial matrix
YLR109W	YLR109W	AHP1	hom	Verified	1.10516367189153	0.13454433750757	no	757	0.128678152442974	464	NA	FT	OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS			Thiol-specific peroxiredoxin, reduces hydroperoxides to protect against oxidative damage; function in vivo requires covalent conjugation to Urm1p	cellular response to oxidative stress|response to metal ion|cell redox homeostasis	thioredoxin peroxidase activity	plasma membrane|cytoplasm
YDL218W_p	YDL218W	YDL218W	hom	Uncharacterized	1.10230322014195	0.135164934947594	no	758	0.0929851417210287	346	NA					Putative protein of unknown function; YDL218W transcription is regulated by Azf1p and induced by starvation and aerobic conditions; expression also induced in cells treated with the mycotoxin patulin	biological_process	molecular_function	integral to membrane|cytoplasm
YPR052C	YPR052C	NHP6A	hom	Verified	1.10058615409294	0.135538407166525	no	759	0.122943007762091	467	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		High-mobility group (HMG) protein, binds to and remodels nucleosomes; involved in recruiting FACT and other chromatin remodelling complexes to chromosomes; functionally redundant with Nhp6Bp; homologous to mammalian HMGB1 and HMGB2; NHP6A has a paralog, NHP6B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress	mismatch repair|DNA replication-independent nucleosome organization|RNA polymerase II transcriptional preinitiation complex assembly|RNA polymerase III transcriptional preinitiation complex assembly|chromatin remodeling	nucleosome binding|sequence-specific DNA binding|DNA binding, bending	MutSalpha complex|nucleus
YCL046W_d	YCL046W	YCL046W	hom	Dubious	1.09685750774053	0.136351843201795	no	760	0.152491743354975	564	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YCL045C	Unknown	Unknown	Unknown
YLL057C	YLL057C	JLP1	hom	Verified	1.09586343042872	0.136569272410023	no	761	0.105954372401044	375	NA	FT	OXIDATION-REDUCTION PROCESS			Fe(II)-dependent sulfonate/alpha-ketoglutarate dioxygenase, involved in sulfonate catabolism for use as a sulfur source; contains sequence that resembles a J domain (typified by the E. coli DnaJ protein); induced by sulphur starvation	sulfur compound catabolic process	sulfonate dioxygenase activity	cellular_component
YBR259W	YBR259W	YBR259W	hom	Verified	1.09506713202772	0.136743613448487	no	762	0.138619229316153	458	NA					Protein of unknown function; YBR259W is not an essential gene; forms cytoplasmic foci upon DNA replication stress	biological_process	molecular_function	cellular_component
YBL056W	YBL056W	PTC3	hom	Verified	1.09466083677461	0.136832626055872	no	763	0.126617227413573	497	NA	FT	CELL CYCLE|SIGNALING|PROTEIN PHOSPHORYLATION	NUCLEUS		Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p (see also Ptc2p) to limit maximal kinase activity induced by osmotic stress; dephosphorylates T169 phosphorylated Cdc28p (see also Ptc2p); role in DNA damage checkpoint inactivation; PTC3 has a paralog, PTC2, that arose from the whole genome duplication	inactivation of MAPK activity involved in osmosensory signaling pathway|regulation of cyclin-dependent protein kinase activity|protein dephosphorylation	protein serine/threonine phosphatase activity	nucleus|cytoplasm
YML088W	YML088W	UFO1	hom	Verified	1.09079214122443	0.13768217763813	no	764	0.124624776370143	447	NA	FT	RESPONSE TO DNA DAMAGE|PROTEOLYSIS	NUCLEUS	UBIQUITIN LIGASE COMPLEX	F-box receptor protein, subunit of the Skp1-Cdc53-F-box receptor (SCF) E3 ubiquitin ligase complex; binds to phosphorylated Ho endonuclease, allowing its ubiquitylation by SCF and subsequent degradation	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|cellular response to methylmercury|response to DNA damage stimulus	ubiquitin-protein ligase activity|protein binding, bridging	SCF ubiquitin ligase complex|nucleus|cytoplasm
YOL027C	YOL027C	MDM38	hom	Verified	1.09061715901285	0.137720688004861	no	765	0.146255968016926	496	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|TRANSLATION|ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS	MITOCHONDRION		Mitochondrial protein, forms a complex with Mba1p to facilitate recruitment of mRNA-specific translational activators to ribosomes; roles in protein export and K+/H+ exchange; human ortholog Letm1 implicated in Wolf-Hirschhorn syndrome	potassium ion transport|mitochondrial respiratory chain complex III biogenesis|cellular potassium ion homeostasis|proton transport|positive regulation of mitochondrial translation|mitochondrial respiratory chain complex IV biogenesis|protein insertion into mitochondrial membrane	ribosome binding	mitochondrion|mitochondrial inner membrane
YJR056C	YJR056C	YJR056C	hom	Verified	1.08756034431297	0.138394622615796	no	766	0.0896426746622259	344	NA	FT		NUCLEUS		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; relative distribution to the nucleus increases upon DNA replication stress	biological_process	molecular_function	nucleus|cytoplasm
YFL049W	YFL049W	SWP82	hom	Verified	1.08624075947776	0.138686244347307	no	767	0.12418616222796	433	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION	NUCLEUS	RSC COMPLEX	Member of the SWI/SNF chromatin remodeling complex; has an as yet unidentified role in the complex; has identifiable counterparts in closely related yeast species; abundantly expressed in many growth conditions; paralog of Npl6p; relocates to the cytosol under hypoxic conditions	positive regulation of transcription from RNA polymerase II promoter	molecular_function	SWI/SNF complex|nucleus
YJR151W-A_p	YJR151W-A	YJR151W-A	hom	Uncharacterized	1.08364365692649	0.139261413064082	no	768	0.131165143372499	428	NA					Putative protein of unknown function; identified by fungal homology and RT-PCR; predicted to have a role in transcription based on computational guilt by association analysis	biological_process	molecular_function	cellular_component
YLR004C	YLR004C	THI73	hom	Verified	1.08337040164716	0.13932202392945	no	769	0.118880788826004	387	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|PLASMA MEMBRANE		Putative plasma membrane permease proposed to be involved in carboxylic acid uptake and repressed by thiamine; substrate of Dbf2p/Mob1p kinase; transcription is altered if mitochondrial dysfunction occurs	transport	transporter activity	integral to membrane|endoplasmic reticulum
YDL051W	YDL051W	LHP1	hom	Verified	1.08233167784137	0.139552587453347	no	770	0.141054084167331	497	NA	FT	RNA PROCESSING	NUCLEUS		RNA binding protein required for maturation of tRNA and U6 snRNA precursors; acts as a molecular chaperone for RNAs transcribed by polymerase III; homologous to human La (SS-B) autoantigen	tRNA processing	RNA binding|tRNA binding	nucleoplasm|nucleolus|nucleus
YJR078W	YJR078W	BNA2	hom	Verified	1.08099444921275	0.139849791387949	no	771	0.113478334395776	418	NA	FT	OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM			Putative tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase, required for de novo biosynthesis of NAD from tryptophan via kynurenine; interacts genetically with telomere capping gene CDC13; regulated by Hst1p and Aftp	de novo NAD biosynthetic process from tryptophan	tryptophan 2,3-dioxygenase activity|indoleamine 2,3-dioxygenase activity	cytoplasm
YMR210W	YMR210W	YMR210W	hom	Verified	1.08066996325493	0.139921974390786	no	772	0.10811706891825	350	NA	FT	KETONE METABOLISM|LIPID METABOLISM			Putative acyltransferase with similarity to Eeb1p and Eht1p, has a minor role in medium-chain fatty acid ethyl ester biosynthesis; may be involved in lipid metabolism and detoxification	medium-chain fatty acid biosynthetic process	transferase activity, transferring acyl groups	cellular_component
YDL011C_d	YDL011C	YDL011C	hom	Dubious	1.08013846111105	0.140040263542979	no	773	0.12695185488258	445	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the uncharacterized ORF YDL010W	Unknown	Unknown	Unknown
YAL028W	YAL028W	FRT2	hom	Verified	1.07576864347942	0.141015369579556	no	774	0.100193360141059	359	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Tail-anchored ER membrane protein of unknown function; interacts with homolog Frt1p; promotes growth in conditions of high Na+, alkaline pH, or cell wall stress, possibly via a role in posttranslational translocation; potential Cdc28p substrate; FRT2 has a paralog, FRT1, that arose from the whole genome duplication	response to stress	molecular_function	endoplasmic reticulum
YJR088C	YJR088C	EMC2	hom	Verified	1.07388252377689	0.141437668498654	no	775	0.112698646015219	442	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm Y57G7A.10/EMC-2, fly CG17556, human TTC35	protein folding in endoplasmic reticulum	molecular_function	ER membrane protein complex|endoplasmic reticulum
YGR117C_p	YGR117C	YGR117C	hom	Uncharacterized	1.07194710281322	0.141871895970807	no	776	0.108027456249878	349	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	biological_process	molecular_function	cytoplasm
YKR031C	YKR031C	SPO14	hom	Verified	1.07162365500545	0.141944552065891	no	777	0.136431978947765	501	NA	FT	VESICLE-MEDIATED TRANSPORT|CELL CYCLE|LIPID METABOLISM	NUCLEUS		Phospholipase D; catalyzes the hydrolysis of phosphatidylcholine, producing choline and phosphatidic acid; involved in Sec14p-independent secretion; required for meiosis and spore formation; differently regulated in secretion and meiosis; participates in transcription initiation and/or early elongation of specific genes; interacts with foot domain of RNA polymerase II; deletion results in abnormal CTD-Ser5 phosphorylation of RNA polymerase II at specific promoter regions	phospholipid metabolic process|exocytosis|cell morphogenesis involved in conjugation with cellular fusion|ascospore-type prospore assembly	phospholipase D activity|phosphatidylinositol-3-phosphate binding	endosome|nucleus|prospore membrane
YER135C_d	YER135C	YER135C	hom	Dubious	1.07105239003346	0.142072936870565	no	778	0.158022045551368	525	NA					Dubious open reading frame unlikely to encode a protein; YER135C is not an essential gene	Unknown	Unknown	Unknown
YPL105C	YPL105C	SYH1	hom	Verified	1.07068145015532	0.142156343140307	no	779	0.137686310406205	540	NA	FT	PROTEIN LOCALIZATION	MITOCHONDRION		Protein of unknown function that influences nuclear pore distribution; co-purifies with ribosomes; contains a GYF domain, which bind proline-rich sequences; deletion extends chronological lifespan; SYH1 has a paralog, SMY2, that arose from the whole genome duplication	nuclear pore distribution	molecular_function	mitochondrion|ribosome|cytoplasmic mRNA processing body|extrinsic to membrane|cytoplasm
YDR090C_p	YDR090C	YDR090C	hom	Uncharacterized	1.06940337032664	0.142443974653704	no	780	0.160821094315907	565	NA	FT		PLASMA MEMBRANE		Putative protein of unknown function	biological_process	molecular_function	integral to membrane
YMR058W	YMR058W	FET3	hom	Verified	1.06808310277233	0.142741513595136	no	781	0.156063555202483	564	NA	FT	ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS	PLASMA MEMBRANE		Ferro-O2-oxidoreductase; required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity, belongs to class of integral membrane multicopper oxidases; protein abundance increases in response to DNA replication stress	iron assimilation by reduction and transport|high-affinity iron ion transport|response to copper ion	ferroxidase activity|iron ion transmembrane transporter activity	integral to membrane|high affinity iron permease complex|plasma membrane
YGR237C_p	YGR237C	YGR237C	hom	Uncharacterized	1.06801786963254	0.142756225590395	no	782	0.135549249813187	488	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	biological_process	molecular_function	cytoplasm
YPL103C	YPL103C	FMP30	hom	Verified	1.0675232990057	0.142867799186004	no	783	0.143978733614453	509	NA	FT	LIPID METABOLISM	MITOCHONDRION		Mitochondrial inner membrane protein with a role in maintaining mitochondrial morphology and normal cardiolipin levels; proposed to be involved in N-acylethanolamine metabolism; related to mammalian N-acylPE-specific phospholipase D	N-acylphosphatidylethanolamine metabolic process|N-acylethanolamine metabolic process	NAPE-specific phospholipase D activity	mitochondrion|integral to mitochondrial inner membrane
YJR127C	YJR127C	RSF2	hom	Verified	1.06732457130909	0.142912648131092	no	784	0.100872921263922	379	NA	FT		NUCLEUS		Zinc-finger protein; involved in transcriptional control of both nuclear and mitochondrial genes, many of which specify products required for glycerol-based growth, respiration, and other functions; RSF2 has a paralog, TDA9, that arose from the whole genome duplication; relocalizes from nucleus to cytoplasm upon DNA replication stress	regulation of transcription, DNA-dependent	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	nucleus
YDR496C	YDR496C	PUF6	hom	Verified	1.06704787787809	0.142975108258658	no	785	0.120955164849636	422	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION	NUCLEUS|SITE OF POLARIZED GROWTH	RIBOSOME	Pumilio-homology domain protein that binds the 3' UTR of ASH1 mRNA and represses its translation, resulting in proper asymmetric localization of ASH1 mRNA; also co-sediments with the 60S ribosomal subunit and is required for its biogenesis	ribosomal large subunit biogenesis|negative regulation of translation	mRNA 3'-UTR binding|translation repressor activity, nucleic acid binding	nucleolus|nucleus|large ribosomal subunit
YOR343C_d	YOR343C	YOR343C	hom	Dubious	1.06700674714396	0.142984394588926	no	786	0.120733870396074	475	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YNR058W	YNR058W	BIO3	hom	Verified	1.06689560156446	0.143009490625586	no	787	0.15236551513631	568	NA	FT	KETONE METABOLISM|COFACTOR METABOLISM			7,8-diamino-pelargonic acid aminotransferase (DAPA), catalyzes the second step in the biotin biosynthesis pathway; BIO3 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis	biotin biosynthetic process	adenosylmethionine-8-amino-7-oxononanoate transaminase activity	cytoplasm
YHR168W	YHR168W	MTG2	hom	Verified	1.06585462379801	0.143244681929698	no	788	0.133911890895167	476	NA	FT	TRANSLATION|NUCLEOTIDE METABOLISM	MITOCHONDRION		Putative GTPase, member of the Obg family; peripheral protein of the mitochondrial inner membrane that associates with the large ribosomal subunit; required for mitochondrial translation, possibly via a role in ribosome assembly	cytoplasmic translation	ribosome binding|GTPase activity	mitochondrial inner membrane|extrinsic to membrane
YKR095W	YKR095W	MLP1	hom	Verified	1.06562803339891	0.143295910795361	no	789	0.133337832582223	438	NA	FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS|CYTOSKELETON		Myosin-like protein associated with the nuclear envelope, connects the nuclear pore complex with the nuclear interior; involved with Tel1p in telomere length control; involved with Pml1p and Pml39p in nuclear retention of unspliced mRNAs	protein localization to nuclear pore|poly(A)+ mRNA export from nucleus|protein import into nucleus|transcriptional activation by promoter-terminator looping|nuclear retention of unspliced pre-mRNA at the site of transcription|telomere tethering at nuclear periphery	ribonucleoprotein complex binding	nucleoplasm|nuclear envelope|integral to membrane|ribonucleoprotein complex|spindle pole body
YBL064C	YBL064C	PRX1	hom	Verified	1.06500449578184	0.143436947643787	no	790	0.0994684193455214	375	NA	FT	OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS	MITOCHONDRION		Mitochondrial peroxiredoxin with thioredoxin peroxidase activity; has a role in reduction of hydroperoxides; reactivation requires Trr2p and glutathione; induced during respiratory growth and oxidative stress; phosphorylated; protein abundance increases in response to DNA replication stress	response to cadmium ion|cellular response to oxidative stress|cell redox homeostasis	thioredoxin peroxidase activity	mitochondrion
YMR192W	YMR192W	GYL1	hom	Verified	1.0620250050076	0.144112166849185	no	791	0.125113521855058	445	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING|NUCLEOTIDE METABOLISM	MITOCHONDRION|GOLGI APPARATUS|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Putative GTPase activating protein (GAP) with a role in exocytosis; stimulates Gyp5p GAP activity on Ypt1p, colocalizes with Gyp5p at sites of polarized growth; interacts with Gyp5p, Rvs161p, and Rvs167p; involved in recruiting Rvs167p to the bud tip during polarized growth; increases in abundance and relocalizes from bud neck to cytoplasm upon DNA replication stress	ER to Golgi vesicle-mediated transport|regulation of exocytosis	protein binding	mitochondrion|incipient cellular bud site|cellular bud|cellular bud neck|cellular bud tip|cytoplasm|Golgi-associated vesicle|plasma membrane
YGL003C	YGL003C	CDH1	hom	Verified	1.06044702616026	0.144470638878692	no	792	0.153309444398894	561	NA	FT	CELL CYCLE|CELL DIVISION|PROTEOLYSIS|CYTOSKELETON ORGANIZATION	NUCLEUS	UBIQUITIN LIGASE COMPLEX	Cell-cycle regulated activator of the anaphase-promoting complex/cyclosome (APC/C), which directs ubiquitination of cyclins resulting in mitotic exit; targets the APC/C to specific substrates including Cdc20p, Ase1p, Cin8p and Fin1p	activation of mitotic anaphase-promoting complex activity|negative regulation of spindle pole body separation|positive regulation of mitotic metaphase/anaphase transition|Unknown|regulation of cell size	anaphase-promoting complex binding|cyclin binding|ubiquitin-protein ligase activator activity	nucleus|anaphase-promoting complex|cytoplasm
YKL072W	YKL072W	STB6	hom	Verified	1.05871726577931	0.144864281123945	no	793	0.103657013274255	365	NA					Protein that binds Sin3p in a two-hybrid assay	biological_process	molecular_function	cellular_component
YNL254C	YNL254C	RTC4	hom	Verified	1.05848201973414	0.144917871892909	no	794	0.117126814865311	420	NA	FT		NUCLEUS		Protein of unknown function; null mutation suppresses cdc13-1 temperature sensitivity; (GFP)-fusion protein localizes to both the cytoplasm and the nucleus	biological_process	molecular_function	nucleus|cytoplasm
YPL269W	YPL269W	KAR9	hom	Verified	1.05824721403262	0.144971375656881	no	795	0.188951585357285	668	NA	FT		NUCLEUS|SITE OF POLARIZED GROWTH|CYTOSKELETON		Karyogamy protein required for correct positioning of the mitotic spindle and for orienting cytoplasmic microtubules, localizes at the shmoo tip in mating cells and at the tip of the growing bud in small-budded cells through anaphase	nuclear migration along microtubule|establishment of spindle localization	molecular_function	cell cortex|spindle pole body|mating projection tip
YDR026C	YDR026C	NSI1	hom	Verified	1.05653100778518	0.145362841035545	no	796	0.118778818084613	382	NA	FT	CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS|CHROMOSOME		RNA polymerase I termination factor; binds to rDNA terminator element, required for efficient Pol I termination; required for rDNA silencing at NTS1; facilities association of Sir2p with NTS1, contributes to rDNA stability and cell longevity; interacts physically with Fob1p and RENT subunits, Sir2p and Net1p; may interact with ribosomes, based on co-purification experiments; Myb-like DNA-binding protein; NSI1 has a paralog, REB1, that arose from the whole genome duplication	termination of RNA polymerase I transcription|chromatin silencing at rDNA|Unknown	DNA binding	ribosome|nucleolus|rDNA heterochromatin
YGR020C	YGR020C	VMA7	hom	Verified	1.05589151765196	0.145508889942539	no	797	0.198793597123434	704	NA	FF|FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Subunit F of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane	vacuolar acidification	proton-transporting ATPase activity, rotational mechanism	fungal-type vacuole membrane|vacuolar proton-transporting V-type ATPase, V1 domain|integral to membrane
YLR138W	YLR138W	NHA1	hom	Verified	1.05509913093782	0.14568999473508	no	798	0.130898202323872	457	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Na+/H+ antiporter involved in sodium and potassium efflux through the plasma membrane; required for alkali cation tolerance at acidic pH	cellular potassium ion homeostasis|cellular monovalent inorganic cation homeostasis|response to osmotic stress	cation:cation antiporter activity|sodium:hydrogen antiporter activity	membrane raft|integral to membrane|plasma membrane
YKL015W	YKL015W	PUT3	hom	Verified	1.05403839919635	0.145932668522536	no	799	0.123208138728041	446	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Transcriptional activator of proline utilization genes, constitutively binds PUT1 and PUT2 promoter sequences as a dimer and undergoes a conformational change to form the active state; differentially phosphorylated in the presence of different nitrogen sources; has a Zn(2)-Cys(6) binuclear cluster domain	Unknown|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YLL038C	YLL038C	ENT4	hom	Verified	1.05379363204453	0.145988704802698	no	800	0.0912509648226388	329	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION	CYTOSKELETON		Protein of unknown function, contains an N-terminal epsin-like domain; proposed to be involved in the trafficking of Arn1p in the absence of ferrichrome	endocytosis|actin filament organization|establishment of protein localization to plasma membrane|actin cortical patch assembly	clathrin binding	actin cortical patch
YOR205C	YOR205C	GEP3	hom	Verified	1.05344412617558	0.146068744717885	no	801	0.143136236103582	548	NA	FT		MITOCHONDRION		Protein required for mitochondrial ribosome small subunit biogenesis; null mutant is defective in respiration and in maturation of 15S rRNA; protein is localized to the mitochondrial inner membrane; null mutant interacts synthetically with prohibitin (phb1)	maturation of SSU-rRNA	molecular_function	mitochondrion|mitochondrial inner membrane
YKL218C	YKL218C	SRY1	hom	Verified	1.05326855877334	0.146108962317547	no	802	0.132574908717844	485	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			3-hydroxyaspartate dehydratase, deaminates L-threo-3-hydroxyaspartate to form oxaloacetate and ammonia; required in the presence of hydroxyaspartate; highly similar to mouse serine racemase (Srr) but has no serine racemase activity	cellular modified amino acid catabolic process	serine racemase activity|threo-3-hydroxyaspartate ammonia-lyase activity	cellular_component
YOR344C	YOR344C	TYE7	hom	Verified	1.05278336892392	0.146220144471628	no	803	0.138335392470373	483	NA	FT	CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS|CHROMOSOME		Serine-rich protein that contains a basic-helix-loop-helix (bHLH) DNA binding motif; binds E-boxes of glycolytic genes and contributes to their activation; may function as a transcriptional activator in Ty1-mediated gene expression	positive regulation of glycolysis|transcription, DNA-dependent	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	nuclear chromatin|nucleus
YDL013W	YDL013W	SLX5	hom	Verified	1.05176235630321	0.146454296959798	no	804	0.193593389329146	672	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS	UBIQUITIN LIGASE COMPLEX	Subunit of the Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex, stimulated by SUMO-modified substrates; contains a RING domain and two SIMs (SUMO-interacting motifs); forms SUMO-dependent nuclear foci, including DNA repair centers	protein sumoylation|telomere maintenance|response to DNA damage stimulus|protein ubiquitination	SUMO binding|ubiquitin-protein ligase activity	ubiquitin ligase complex|nucleus
YJL206C_p	YJL206C	YJL206C	hom	Uncharacterized	1.05089394227132	0.146653651455936	no	805	0.137970081283819	520	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Putative protein of unknown function; similar to transcriptional regulators from the Zn[2]-Cys[6] binuclear cluster protein family; mRNA is weakly cell cycle regulated, peaking in S phase; induced rapidly upon MMS treatment	biological_process	molecular_function	cellular_component
YOL107W_p	YOL107W	YOL107W	hom	Uncharacterized	1.05026860984029	0.146797316478522	no	806	0.135368110570312	503	NA	FT		ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and colocalizes in a punctate pattern with the early golgi/COPI vesicles; YOL107W is not an essential protein	biological_process	molecular_function	COPI-coated vesicle|Golgi apparatus
YPL097W	YPL097W	MSY1	hom	Verified	1.04956010950443	0.146960202698611	no	807	0.15833207504514	555	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial tyrosyl-tRNA synthetase	mitochondrial tyrosyl-tRNA aminoacylation	tyrosine-tRNA ligase activity	mitochondrion
YFL016C	YFL016C	MDJ1	hom	Verified	1.04693480835126	0.147564823218307	no	808	0.209511553262153	651	NA	FT	PROTEOLYSIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Co-chaperone that stimulates the ATPase activity of the HSP70 protein Ssc1p; involved in protein folding/refolding in the mitochodrial matrix; required for proteolysis of misfolded proteins; member of the HSP40 (DnaJ) family of chaperones	protein refolding|response to heat|misfolded or incompletely synthesized protein catabolic process|mitochondrial genome maintenance|'de novo' protein folding	unfolded protein binding|ATPase activator activity	extrinsic to mitochondrial inner membrane|mitochondrion|mitochondrial matrix
YEL041W	YEL041W	YEF1	hom	Verified	1.04676335377163	0.147604367984731	no	809	0.173550782391161	572	NA	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM			ATP-NADH kinase; phosphorylates both NAD and NADH; homooctameric structure consisting of 60-kDa subunits; similar to Pos5p; overexpression complements certain pos5 phenotypes; YEF1 has a paralog, UTR1, that arose from the whole genome duplication	NADP biosynthetic process	NAD+ kinase activity|NADH kinase activity	cellular_component
YPL026C	YPL026C	SKS1	hom	Verified	1.04450637786226	0.148125584980337	no	810	0.0930697567543113	357	NA	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN PHOSPHORYLATION	NUCLEUS		Putative serine/threonine protein kinase; involved in the adaptation to low concentrations of glucose independent of the SNF3 regulated pathway	glucose transport|protein phosphorylation|response to glucose stimulus|positive regulation of transcription from RNA polymerase II promoter	protein serine/threonine kinase activity|protein kinase activity	nucleus|cytoplasm
YNR062C_p	YNR062C	YNR062C	hom	Uncharacterized	1.04402151088661	0.1482377187411	no	811	0.137920108541655	514	NA					Putative membrane protein of unknown function	biological_process	molecular_function	integral to membrane
YDR374C_p	YDR374C	YDR374C	hom	Uncharacterized	1.04277296493934	0.148526727641691	no	812	0.121731733084786	417	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YLL045C	YLL045C	RPL8B	hom	Verified	1.04183804850847	0.148743385242694	no	813	0.13715005725008	489	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L8B; mutation results in decreased amounts of free 60S subunits; homologous to mammalian ribosomal protein L7A, no bacterial homolog; RPL8B has a paralog, RPL8A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YGR220C	YGR220C	MRPL9	hom	Verified	1.04130770122709	0.148866381814169	no	814	0.132146725797684	431	NA	FT	TRANSLATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit	cytoplasmic translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YBR262C	YBR262C	AIM5	hom	Verified	1.04125144932218	0.148879431574856	no	815	0.100978283866573	334	NA	FT	MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial inner membrane protein; subunit of the mitochondrial inner membrane organizing system (MitOS, MICOS, or MINOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture	cristae formation	molecular_function	mitochondrion|mitochondrial crista junction|integral to mitochondrial inner membrane
YBR199W	YBR199W	KTR4	hom	Verified	1.04061865201516	0.149026285551826	no	816	0.101460926643036	386	NA	FT	CARBOHYDRATE METABOLISM	GOLGI APPARATUS		Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family	protein N-linked glycosylation	mannosyltransferase activity	Golgi apparatus
YER174C	YER174C	GRX4	hom	Verified	1.04055114707195	0.149041957209357	no	817	0.149934819797602	530	NA	FT	ION HOMEOSTASIS|CYTOSKELETON ORGANIZATION|ION HOMEOSTASIS|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx3p and Grx5p; protects cells from oxidative damage; mutant has increased aneuploidy tolerance; transcription is regulated by Yap5	cellular iron ion homeostasis|cellular response to oxidative stress|actin cytoskeleton organization	disulfide oxidoreductase activity	nucleus
YMR109W	YMR109W	MYO5	hom	Verified	1.04009194512508	0.149148592775008	no	818	0.132080806591066	482	NA	FT	VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS|CELL DIVISION	SITE OF POLARIZED GROWTH|CYTOSKELETON		One of two type I myosins; contains proline-rich tail homology 2 (TH2) and SH3 domains; MYO5 deletion has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization	bipolar cellular bud site selection|endocytosis|exocytosis|fungal-type cell wall organization|response to salt stress|receptor-mediated endocytosis|actin cortical patch localization|response to osmotic stress	microfilament motor activity	mating projection tip|actin cortical patch
YAL027W	YAL027W	SAW1	hom	Verified	1.03532377895982	0.150258864203232	no	819	0.111192143102236	445	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		5'- and 3'-flap DNA binding protein; stimulates the endonuclease activity of Rad1/Rad10p; involved in Rad1p/Rad10p-dependent removal of 3'-nonhomologous tails during double-strand break repair via single-strand annealing; green fluorescent protein (GFP)-fusion protein localizes to the nucleus	double-strand break repair via single-strand annealing, removal of nonhomologous ends	molecular_function	nucleus
YPL239W	YPL239W	YAR1	hom	Verified	1.03522978495341	0.150280806002888	no	820	0.150343929019915	511	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RESPONSE TO OXIDATIVE STRESS			Ankyrin-repeat containing, nucleocytoplasmic shuttling chaperone; prevents aggregation of Rps3p in the cytoplasm, associates with free Rps3p in the cytoplasm and delivers it to the 90S in the nucleus; required for 40S ribosomal subunit export, biogenesis and adaptation to osmotic and oxidative stress; expression repressed by heat shock	ribosomal small subunit biogenesis|cellular response to oxidative stress|response to osmotic stress	molecular_function	cytoplasm
YOR086C	YOR086C	TCB1	hom	Verified	1.03310172456778	0.150778148194017	no	821	0.126274634671068	456	NA	FT		ENDOPLASMIC RETICULUM|MITOCHONDRION|PLASMA MEMBRANE		Lipid-binding ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; contains three calcium and lipid binding domains; non-tagged protein also localizes to mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact	biological_process	lipid binding	mitochondrion|plasma membrane|cortical endoplasmic reticulum
YIR004W	YIR004W	DJP1	hom	Verified	1.0309036045957	0.151293013047547	no	822	0.131291470791928	451	NA	FT	PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION			Cytosolic J-domain-containing protein, required for peroxisomal protein import and involved in peroxisome assembly, homologous to E. coli DnaJ	protein import into peroxisome matrix	chaperone binding	cytosol
YNL268W	YNL268W	LYP1	hom	Verified	1.03080283172273	0.151316645041978	no	823	0.158513707264055	586	NA	FT		MITOCHONDRION|PLASMA MEMBRANE		Lysine permease; one of three amino acid permeases (Alp1p, Can1p, Lyp1p) responsible for uptake of cationic amino acids	basic amino acid transport	basic amino acid transmembrane transporter activity	mitochondrion|integral to membrane|plasma membrane
YLR307W	YLR307W	CDA1	hom	Verified	1.03074360627946	0.151330534997947	no	824	0.118614966011453	422	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM			Chitin deacetylase, together with Cda2p involved in the biosynthesis ascospore wall component, chitosan; required for proper rigidity of the ascospore wall	ascospore wall assembly	chitin deacetylase activity	chitosan layer of spore wall
YLR097C	YLR097C	HRT3	hom	Verified	1.03029556652491	0.151435639816552	no	825	0.125109054957375	429	NA	FT	PROTEOLYSIS		UBIQUITIN LIGASE COMPLEX	Putative SCF-ubiquitin ligase F-box protein, based on both genetic and physical interactions and sequence similarity; identified in association with Cdc53p, Skp1p and Ubi4 in large and small-scale studies	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|cellular response to methylmercury	ubiquitin-protein ligase activity|protein binding, bridging	SCF ubiquitin ligase complex
YKL117W	YKL117W	SBA1	hom	Verified	1.0301531635762	0.15146905602455	no	826	0.134960820064917	452	NA	FT		NUCLEUS		Co-chaperone that binds to and regulates Hsp90 family chaperones; important for pp60v-src activity in yeast; homologous to the mammalian p23 proteins, and like p23 can regulate telomerase activity; protein abundance increases in response to DNA replication stress	protein folding|positive regulation of telomere maintenance via telomerase|regulation of telomerase activity	chaperone binding	nucleus|cytoplasm
YKR051W_p	YKR051W	YKR051W	hom	Uncharacterized	1.02918294905731	0.151696856586211	no	827	0.159050118519524	558	NA					Putative protein of unknown function	biological_process	molecular_function	integral to membrane
YNR064C	YNR064C	YNR064C	hom	Verified	1.02896136959239	0.151748914040335	no	828	0.144725983177865	585	NA					Epoxide hydrolase, member of the alpha/beta hydrolase fold family; may have a role in detoxification of epoxides	response to toxin	epoxide hydrolase activity	cellular_component
YCL024W	YCL024W	KCC4	hom	Verified	1.02789746950155	0.151999030012741	no	829	0.150248218525949	506	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Protein kinase of the bud neck involved in the septin checkpoint; associates with septin proteins, negatively regulates Swe1p by phosphorylation, shows structural homology to bud neck kinases Gin4p and Hsl1p; KCC4 has a paralog, GIN4, that arose from the whole genome duplication	budding cell bud growth|protein phosphorylation|septin checkpoint|septin ring assembly	phosphatidic acid binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylserine binding|protein kinase activity	incipient cellular bud site|cellular bud neck septin collar|plasma membrane|cellular bud neck|septin ring
YPR091C	YPR091C	NVJ2	hom	Verified	1.02772121905844	0.152040491766186	no	830	0.126018798009132	429	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Lipid-binding ER protein, enriched at nucleus-vacuolar junctions (NVJ); may be involved in sterol metabolism or signaling at the NVJ; contains a synaptotagmin-like-mitochondrial- lipid binding protein (SMP) domain; binds phosphatidylinositols and other lipids in a large-scale study; may interact with ribosomes, based on co-purification experiments	biological_process	lipid binding	ribosome|nucleus-vacuole junction|endoplasmic reticulum
YDL149W	YDL149W	ATG9	hom	Verified	1.02756699017128	0.152076779255803	no	831	0.127018464746332	390	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS	ENDOMEMBRANE SYSTEM|MITOCHONDRION		Transmembrane protein involved in forming Cvt and autophagic vesicles; cycles between the phagophore assembly site (PAS) and other cytosolic punctate structures, not found in autophagosomes; may be involved in membrane delivery to the PAS	piecemeal microautophagy of nucleus|mitochondrion degradation|protein homooligomerization|CVT pathway|autophagic vacuole assembly	molecular_function	mitochondrion|integral to membrane|pre-autophagosomal structure
YGL121C	YGL121C	GPG1	hom	Verified	1.0269767599878	0.152215703713728	no	832	0.125263377192927	471	NA	FT	SIGNALING			Proposed gamma subunit of the heterotrimeric G protein that interacts with the receptor Gpr1p; involved in regulation of pseudohyphal growth; requires Gpb1p or Gpb2p to interact with Gpa2p; overproduction causes prion curing	signal transduction|invasive growth in response to glucose limitation	signal transducer activity	cellular_component
YDR194W-A_p	YDR194W-A	YDR194W-A	hom	Uncharacterized	1.02674709103619	0.152269784430801	no	833	0.177992513544711	603	NA					Putative protein of unknown function; identified by fungal homology and RT-PCR	biological_process	molecular_function	cellular_component
YER080W	YER080W	AIM9	hom	Verified	1.02609306223723	0.152423860088648	no	834	0.160099914614234	523	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss	biological_process	molecular_function	mitochondrion
YMR163C	YMR163C	INP2	hom	Verified	1.02580510966537	0.152491728553331	no	835	0.14088613418611	514	NA	FT	PEROXISOME ORGANIZATION			Peroxisome-specific receptor important for peroxisome inheritance; co-fractionates with peroxisome membranes and co-localizes with peroxisomes in vivo; physically interacts with the myosin V motor Myo2p; INP2 is not an essential gene	peroxisome inheritance	protein anchor	peroxisome|integral to peroxisomal membrane|cytoplasm
YJL123C	YJL123C	MTC1	hom	Verified	1.02482664455385	0.152722495953153	no	836	0.155615143096645	581	NA	FT		GOLGI APPARATUS		Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to COPI-coated vesicles (early Golgi); mtc1 is synthetically lethal with cdc13-1	biological_process	molecular_function	COPI-coated vesicle|ribosome|Golgi apparatus|cytoplasm
YKR049C	YKR049C	FMP46	hom	Verified	1.02299732240648	0.153154555908668	no	837	0.138711458628606	491	NA	FT	OXIDATION-REDUCTION PROCESS	MITOCHONDRION		Putative redox protein containing a thioredoxin fold; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	oxidoreductase activity	mitochondrion
YER072W	YER072W	VTC1	hom	Verified	1.02216411659564	0.153351615561203	no	838	0.148299619710029	493	NA	FT	MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT	ENDOPLASMIC RETICULUM		Subunit of the vacuolar transporter chaperone (VTC) complex; VTC complex is involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion; also has mRNA binding activity; protein abundance increases in response to DNA replication stress	polyphosphate metabolic process|vacuolar transport|microautophagy|vacuole fusion, non-autophagic	mRNA binding	integral to membrane|endoplasmic reticulum|vacuolar transporter chaperone complex|intrinsic to vacuolar membrane
YLL023C	YLL023C	POM33	hom	Verified	1.02164181595255	0.153475229337532	no	839	0.143244884170461	471	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM	NUCLEAR PORE	Transmembrane nucleoporin; involved in nuclear pore complex (NPC) distribution, assembly or stabilization; highly conserved across species, orthologous to human TMEM33 and paralogous to Per33p; protein abundance increases in response to DNA replication stress	nuclear pore organization|nuclear pore complex assembly	structural constituent of nuclear pore	ribosome|integral to membrane|endoplasmic reticulum|nuclear pore
YER117W	YER117W	RPL23B	hom	Verified	1.02157595795844	0.153490820744503	no	840	0.149353133247603	560	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L23B; homologous to mammalian ribosomal protein L23 and bacterial L14; RPL23B has a paralog, RPL23A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YDL053C	YDL053C	PBP4	hom	Verified	1.02101888792128	0.153622745038311	no	841	0.161018174691519	567	NA	FT		NUCLEUS		Pbp1p binding protein; interacts strongly with Pab1p-binding protein 1 (Pbp1p) in the yeast two-hybrid system; also interacts with Lsm12p in a copurification assay; relative distribution to the nucleus increases upon DNA replication stress	biological_process	molecular_function	nucleus|cytoplasmic stress granule|cytoplasm
YDL173W	YDL173W	PAR32	hom	Verified	1.02050191951758	0.153745239684482	no	842	0.1834132582971	650	NA					Putative protein of unknown function; hyperphosphorylated upon rapamycin treatment in a Tap42p-dependent manner; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; PAR32 is not an essential gene	biological_process	molecular_function	cytoplasm
YGR208W	YGR208W	SER2	hom	Verified	1.01899710330131	0.154102170865108	no	843	0.14163021363809	522	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Phosphoserine phosphatase of the phosphoglycerate pathway, involved in serine and glycine biosynthesis, expression is regulated by the available nitrogen source	L-serine biosynthetic process	phosphoserine phosphatase activity	nucleus|cytoplasm
YHR018C	YHR018C	ARG4	hom	Verified	1.01869371487311	0.154174198683353	no	844	0.143970373200254	505	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Argininosuccinate lyase, catalyzes the final step in the arginine biosynthesis pathway	arginine biosynthetic process via ornithine	argininosuccinate lyase activity	cytosol
YJR145C	YJR145C	RPS4A	hom	Verified	1.01786908913687	0.154370086590118	no	845	0.146579042119072	539	NA	FT	TRANSLATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; mutation affects 20S pre-rRNA processing; homologous to mammalian ribosomal protein S4, no bacterial homolog; RPS4A has a paralog, RPS4B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic small ribosomal subunit|cytoplasm|90S preribosome
YGL081W_p	YGL081W	YGL081W	hom	Uncharacterized	1.01781200499854	0.154383652880502	no	846	0.119217184828905	390	NA					Putative protein of unknown function; non-essential gene; interacts genetically with CHS5, a gene involved in chitin biosynthesis	biological_process	molecular_function	cellular_component
YPL065W	YPL065W	VPS28	hom	Verified	1.01716994553998	0.154536295358069	no	847	0.178716359580754	673	NA	FF|FT	PROTEIN LOCALIZATION|PROTEOLYSIS|VACUOLAR TRANSPORT			Component of the ESCRT-I complex (Stp22p, Srn2p, Vps28p, and Mvb12p), which is involved in ubiquitin-dependent sorting of proteins into the endosome; conserved C-terminal domain interacts with ESCRT-III subunit Vps20p	protein targeting to membrane|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|protein targeting to vacuole	protein complex binding	endosome|ESCRT I complex
YGR044C	YGR044C	RME1	hom	Verified	1.01392086079846	0.15531025820054	no	848	0.0857727210340665	343	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CELL DIVISION	NUCLEUS		Zinc finger protein involved in control of meiosis; prevents meiosis by repressing IME1 expression and promotes mitosis by activating CLN2 expression; directly repressed by a1-alpha2 regulator; mediates cell type control of sporulation; relocalizes from nucleus to cytoplasm upon DNA replication stress	negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription during meiosis|negative regulation of meiosis|positive regulation of invasive growth in response to glucose limitation by positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription involved in G1/S phase of mitotic cell cycle|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity	nucleus
YMR193C-A_d	YMR193C-A	YMR193C-A	hom	Dubious	1.01350426081845	0.155409680991221	no	849	0.129771478044961	464	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YCR010C	YCR010C	ADY2	hom	Verified	1.01208359180776	0.155749043496892	no	850	0.173950946627847	585	NA	FT	CELL CYCLE|ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION|PLASMA MEMBRANE		Acetate transporter required for normal sporulation; phosphorylated in mitochondria; ADY2 has a paralog, ATO2, that arose from the whole genome duplication	nitrogen utilization|ammonium transport|acetate transport|transmembrane transport	acetate transmembrane transporter activity|ammonium transmembrane transporter activity	mitochondrion|integral to membrane|plasma membrane
YNR036C	YNR036C	MRPS12	hom	Verified	1.00726860455917	0.156902856336561	no	851	0.169986968367582	611	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial protein; may interact with ribosomes based on co-purification experiments; similar to E. coli and human mitochondrial S12 ribosomal proteins	mitochondrial translation	structural constituent of ribosome	mitochondrion|ribosome|mitochondrial small ribosomal subunit
YBR113W_d	YBR113W	YBR113W	hom	Dubious	1.00640767833547	0.157109750786528	no	852	0.125061059699347	442	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CYC8	Unknown	Unknown	Unknown
YDL050C_d	YDL050C	YDL050C	hom	Dubious	1.00426755287913	0.157624834449022	no	853	0.12978406933537	474	NA					Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDL128W	YDL128W	VCX1	hom	Verified	1.00384756494885	0.157726046886521	no	854	0.121979884045966	429	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Vacuolar membrane antiporter with Ca2+/H+ and K+/H+ exchange activity, involved in control of cytosolic Ca2+ and K+ concentrations; has similarity to sodium/calcium exchangers, including the bovine Na+/Ca2+,K+ antiporter	manganese ion transport|cellular calcium ion homeostasis|calcium ion transport|transmembrane transport	potassium:hydrogen antiporter activity|calcium:hydrogen antiporter activity	fungal-type vacuole membrane|integral to membrane|fungal-type vacuole
YOR166C	YOR166C	SWT1	hom	Verified	1.00380159230353	0.15773712837628	no	855	0.137156905238401	473	NA	FT		NUCLEUS		RNA endoribonuclease involved in perinuclear mRNP quality control via the turnover of aberrant, unprocessed pre-mRNAs; interacts with subunits of THO/TREX, TREX-2, and RNA polymerase II; contains a PIN (PilT N terminus) domain	nuclear mRNA surveillance of mRNP export|transcription, DNA-dependent	endoribonuclease activity	nucleus|cytoplasm
YER106W	YER106W	MAM1	hom	Verified	1.00339123359988	0.15783606606558	no	856	0.146840732789078	569	NA	FT	CELL CYCLE|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME	KINETOCHORE	Monopolin, kinetochore associated protein involved in chromosome attachment to meiotic spindle	meiotic chromosome segregation|meiotic sister chromatid cohesion involved in meiosis I	molecular_function	condensed nuclear chromosome kinetochore|monopolin complex
YOR123C	YOR123C	LEO1	hom	Verified	1.00330991129981	0.157855677750416	no	857	0.158566766755142	598	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE	NUCLEUS	RNA POL II, HOLOENZYME	Component of the Paf1 complex; which associates with RNA polymerase II and is involved in histone methylation; plays a role in regulating Ty1 transposition; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay	chromatin organization|Unknown|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription-coupled nucleotide-excision repair|histone H3-K4 trimethylation|transcription elongation from RNA polymerase II promoter	RNA binding|RNA polymerase II transcription factor binding transcription factor activity	nucleus|Cdc73/Paf1 complex
YER051W	YER051W	JHD1	hom	Verified	1.00257422755218	0.158033167952041	no	858	0.154121716007367	533	NA	FT	CHROMATIN ORGANIZATION|OXIDATION-REDUCTION PROCESS	NUCLEUS		JmjC domain family histone demethylase specific for H3-K36, similar to proteins found in human, mouse, drosophila, X. laevis, C. elegans, and S. pombe	histone demethylation	methylated histone residue binding|histone demethylase activity (H3-K36 specific)	cellular_component
YLR096W	YLR096W	KIN2	hom	Verified	1.00235749620639	0.158085481276761	no	859	0.163050478756847	563	NA	FT	VESICLE-MEDIATED TRANSPORT|PROTEIN PHOSPHORYLATION	PLASMA MEMBRANE		Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin1p	protein autophosphorylation|exocytosis|protein phosphorylation	protein serine/threonine kinase activity|protein kinase activity	plasma membrane
YDR322W	YDR322W	MRPL35	hom	Verified	1.00011119502292	0.158628349487102	no	860	0.180559657114831	607	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YGR256W	YGR256W	GND2	hom	Verified	0.999747460713657	0.158716368761516	no	861	0.143195982656712	541	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS			6-phosphogluconate dehydrogenase (decarboxylating); catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone; GND2 has a paralog, GND1, that arose from the whole genome duplication	pentose-phosphate shunt, oxidative branch	phosphogluconate dehydrogenase (decarboxylating) activity	cytosol|plasma membrane
YDR436W	YDR436W	PPZ2	hom	Verified	0.999424835618433	0.15879446689724	no	862	0.151460635499627	519	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Serine/threonine protein phosphatase Z, isoform of Ppz1p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance	cellular sodium ion homeostasis	protein serine/threonine phosphatase activity	cellular_component
YJR121W	YJR121W	ATP2	hom	Verified	0.998783982031508	0.158949673581296	no	863	0.15338604955997	545	NA	FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS	MITOCHONDRION		Beta subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated	ATP synthesis coupled proton transport	hydrogen ion transporting ATP synthase activity, rotational mechanism|ATPase activity|proton-transporting ATPase activity, rotational mechanism	proton-transporting ATP synthase complex, catalytic core F(1)|mitochondrion|mitochondrial proton-transporting ATP synthase, catalytic core|integral to membrane
YAL042W	YAL042W	ERV46	hom	Verified	0.996787200809467	0.159433906097598	no	864	0.174204764588236	578	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Protein localized to COPII-coated vesicles, forms a complex with Erv41p; involved in the membrane fusion stage of transport	ER to Golgi vesicle-mediated transport	molecular_function	integral to endoplasmic reticulum membrane|integral to Golgi membrane|ER to Golgi transport vesicle
YDR525W-A	YDR525W-A	SNA2	hom	Verified	0.996573581010399	0.159485767424242	no	865	0.158953450755161	593	NA					Protein of unknown function, has similarity to Pmp3p, which is involved in cation transport; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern	biological_process	molecular_function	fungal-type vacuole membrane|integral to membrane|cytoplasm
YGL222C	YGL222C	EDC1	hom	Verified	0.995825144645606	0.159667555404549	no	866	0.14956307643032	528	NA	FT	RNA PROCESSING|TRANSLATION	NUCLEUS		RNA-binding protein that activates mRNA decapping directly; binds to the mRNA substrate and enhances the activity of the decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress	deadenylation-dependent decapping of nuclear-transcribed mRNA|positive regulation of translation in response to stress	mRNA binding	nucleus|cytoplasm
YDR335W	YDR335W	MSN5	hom	Verified	0.995808478012659	0.159671605111819	no	867	0.178526474277985	619	NA	FT	PROTEIN LOCALIZATION|RNA LOCALIZATION	NUCLEUS		Karyopherin involved in nuclear import and export of proteins, including import of replication protein A and export of Swi6p, Far1p, and Pho4p; required for re-export of mature tRNAs after their retrograde import from the cytoplasm	tRNA re-export from nucleus|protein export from nucleus	protein binding|importin-alpha export receptor activity	integral to membrane|nucleus|cytoplasm
YML117W	YML117W	NAB6	hom	Verified	0.994488584426702	0.159992530147493	no	868	0.156449752572357	520	NA					Putative RNA-binding protein that associates with mRNAs encoding cell wall proteins in high-throughput studies; deletion mutants display increased sensitivity to some cell wall disrupting agents; expression negatively regulated by cAMP	biological_process	molecular_function	cytoplasm
YPR023C	YPR023C	EAF3	hom	Verified	0.993669729861465	0.160191842115015	no	869	0.134291233988524	475	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME	HISTONE ACETYLTRANSFERASE	Esa1p-associated factor, nonessential component of the NuA4 acetyltransferase complex, homologous to Drosophila dosage compensation protein MSL3; plays a role in regulating Ty1 transposition	DNA repair|histone acetylation|regulation of DNA-dependent DNA replication initiation|negative regulation of antisense RNA transcription|regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|histone deacetylation	histone acetyltransferase activity	Rpd3S complex|histone acetyltransferase complex|Rpd3L complex|NuA4 histone acetyltransferase complex
YJL127C-B_p	YJL127C-B	YJL127C-B	hom	Uncharacterized	0.99324623157846	0.1602949866799	no	870	0.14262733164871	497	NA					Putative protein of unknown function; identified based on homology to the filamentous fungus, <i>Ashbya gossypii</i>	biological_process	molecular_function	cellular_component
YKR048C	YKR048C	NAP1	hom	Verified	0.991926807887827	0.160616615384328	no	871	0.166883099403209	601	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|CHROMATIN ORGANIZATION|CELL DIVISION	NUCLEUS|SITE OF POLARIZED GROWTH|CHROMOSOME		Protein that interacts with mitotic cyclin Clb2p; required for the regulation of microtubule dynamics during mitosis; controls bud morphogenesis; involved in the transport of H2A and H2B histones to the nucleus; phosphorylated by CK2; protein abundance increases in response to DNA replication stress	budding cell bud growth|M phase of mitotic cell cycle|nucleosome disassembly|protein import into nucleus|nucleosome assembly	cyclin binding|histone binding	nucleus|nuclear nucleosome|cytoplasm
YER030W	YER030W	CHZ1	hom	Verified	0.991899553953166	0.160623263367255	no	872	0.12204811944389	408	NA	FT	CHROMATIN ORGANIZATION	NUCLEUS		Histone chaperone for Htz1p/H2A-H2B dimer; required for the stabilization of the Chz1p-Htz1-H2B complex; has overlapping function with Nap1p; null mutant displays weak sensitivity to MMS and benomyl; contains a highly conserved CHZ motif; protein abundance increases in response to DNA replication stress	chromatin remodeling	histone binding	chromatin assembly complex|nucleus
YGL021W	YGL021W	ALK1	hom	Verified	0.99165316499117	0.160683372556357	no	873	0.163347368610667	551	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION			Protein kinase; accumulation and phosphorylation are periodic during the cell cycle; phosphorylated in response to DNA damage; contains characteristic motifs for degradation via the APC pathway; ALK1 has a paralog, ALK2, that arose from the whole genome duplication; similar to mammalian haspins	mitosis|protein phosphorylation	protein serine/threonine kinase activity|protein kinase activity	cellular_component
YDL203C	YDL203C	ACK1	hom	Verified	0.990660941138406	0.160925584720646	no	874	0.160114618620202	499	NA	FT	SIGNALING|CELL WALL ORG/BIOGENESIS	MITOCHONDRION		Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria	fungal-type cell wall organization|positive regulation of signal transduction	molecular_function	mitochondrion
YCR037C	YCR037C	PHO87	hom	Verified	0.990359783274327	0.160999147609464	no	875	0.163825310402387	588	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Low-affinity inorganic phosphate (Pi) transporter; involved in activation of PHO pathway; expression is independent of Pi concentration and Pho4p activity; contains 12 membrane-spanning segments; PHO87 has a paralog, PHO90, that arose from the whole genome duplication	phosphate ion transport|transmembrane transport	inorganic phosphate transmembrane transporter activity	integral to membrane|membrane
YDR309C	YDR309C	GIC2	hom	Verified	0.990069936052381	0.161069968406135	no	876	0.142351251894608	506	NA	FT	CELL CYCLE|SIGNALING|CELL DIVISION	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON		Redundant rho-like GTPase Cdc42p effector; homolog of Gic1p; involved in initiation of budding and cellular polarization; interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain and with PI(4,5)P2 via a polybasic region	regulation of exit from mitosis|establishment of cell polarity|axial cellular bud site selection|Rho protein signal transduction	Rho GTPase binding|Rho GTPase activator activity|phosphatidylinositol-4,5-bisphosphate binding	incipient cellular bud site|actin cap|plasma membrane|mating projection tip|cellular bud tip
YFR033C	YFR033C	QCR6	hom	Verified	0.98957499137276	0.161190949369993	no	877	0.16129314249751	571	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Subunit 6 of the ubiquinol cytochrome-c reductase complex; the complex, also known as the cytochrome bc(1) complex or Complex III, is a component of the mitochondrial inner membrane electron transport chain; highly acidic protein; required for maturation of cytochrome c1; may be loosely associated with the complex since it is easily released into the intermembrane space	mitochondrial electron transport, ubiquinol to cytochrome c|aerobic respiration	ubiquinol-cytochrome-c reductase activity	mitochondrion|integral to membrane|mitochondrial respiratory chain complex III
YIR021W-A_p	YIR021W-A	YIR021W-A	hom	Uncharacterized	0.987262621354868	0.161756954902332	no	878	0.16419370278907	545	NA					Putative protein of unknown function; identified by expression profiling and mass spectrometry	biological_process	molecular_function	cellular_component
YNL203C_d	YNL203C	YNL203C	hom	Dubious	0.987018080485968	0.161816887519171	no	879	0.167290106766563	645	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YGR127W_p	YGR127W	YGR127W	hom	Uncharacterized	0.986955527809563	0.161832220391092	no	880	0.139947240283055	495	NA					Putative protein of unknown function; expression is regulated by Msn2p/Msn4p, indicating a possible role in stress response	biological_process	molecular_function	cellular_component
YOR020W-A_p	YOR020W-A	YOR020W-A	hom	Uncharacterized	0.986886928381407	0.161849036527238	no	881	0.145573621369991	491	NA	FT		MITOCHONDRION		Putative protein of unknown function, conserved in A. gossypii; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YBR280C	YBR280C	SAF1	hom	Verified	0.984706609470552	0.162384102611291	no	882	0.162334772302775	561	NA	FT	PROTEOLYSIS		UBIQUITIN LIGASE COMPLEX	F-Box protein involved in proteasome-dependent degradation of Aah1p during entry of cells into quiescence; interacts with Skp1	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	ubiquitin-protein ligase activity	SCF ubiquitin ligase complex
YER107C	YER107C	GLE2	hom	Verified	0.984108545097113	0.162531072940351	no	883	0.219536732699746	771	NA	FF|FT	PROTEIN LOCALIZATION|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	RNA export factor associated with the nuclear pore complex (NPC); associates with NUP116p; required for polyadenylated RNA export but not for protein import; homologous to S. pombe Rae1p and human RAE1	poly(A)+ mRNA export from nucleus|Unknown|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|nuclear pore distribution|transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery	molecular_function	integral to membrane|nuclear pore|cytoplasm
YOR264W	YOR264W	DSE3	hom	Verified	0.983896197778654	0.162583276691949	no	884	0.151767881657624	530	NA	FT	CELL CYCLE	SITE OF POLARIZED GROWTH		Daughter cell-specific protein, may help establish daughter fate; relocalizes from bud neck to cytoplasm upon DNA replication stress	biological_process	molecular_function	cellular bud neck
YOR313C	YOR313C	SPS4	hom	Verified	0.983451889446201	0.162692541341651	no	885	0.16186379895195	573	NA	FT	CELL CYCLE			Protein whose expression is induced during sporulation; not required for sporulation; heterologous expression in E. coli induces the SOS response that senses DNA damage	ascospore formation	molecular_function	cellular_component
YPL040C	YPL040C	ISM1	hom	Verified	0.981910395744217	0.163071996910203	no	886	0.183667692759821	628	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth	isoleucyl-tRNA aminoacylation|mitochondrial isoleucyl-tRNA aminoacylation|mitochondrial translation	isoleucine-tRNA ligase activity	mitochondrion
YGR007W	YGR007W	ECT1	hom	Verified	0.979115564141791	0.163761441090044	no	887	0.170097163730221	552	NA	FT	LIPID METABOLISM	NUCLEUS		Ethanolamine-phosphate cytidylyltransferase, catalyzes the second step of phosphatidylethanolamine biosynthesis; involved in the maintenance of plasma membrane; similar to mammalian CTP: phosphocholine cytidylyl-transferases	phosphatidylethanolamine biosynthetic process	ethanolamine-phosphate cytidylyltransferase activity	nucleus|cytoplasm
YHR001W	YHR001W	OSH7	hom	Verified	0.97901863913086	0.163785384972666	no	888	0.136172453806881	457	NA	FT	VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT	ENDOPLASMIC RETICULUM		Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability	maintenance of cell polarity|endocytosis|exocytosis|sterol transport|sterol metabolic process|late endosome to vacuole transport	lipid binding|oxysterol binding	integral to membrane|cortical endoplasmic reticulum|cytoplasm
YJL169W_d	YJL169W	YJL169W	hom	Dubious	0.977431309225697	0.164177834521475	no	889	0.152145340782386	538	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL168C/SET2	Unknown	Unknown	Unknown
YPL057C	YPL057C	SUR1	hom	Verified	0.973571607726783	0.16513464469556	no	890	0.146837448636167	537	NA	FT	LIPID METABOLISM			Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit; forms a complex with regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Csh1p; SUR1 has a paralog, CSH1, that arose from the whole genome duplication	glycosphingolipid biosynthetic process|mannosyl-inositol phosphorylceramide metabolic process|sphingolipid biosynthetic process	mannosyltransferase activity|transferase activity, transferring glycosyl groups	integral to membrane|intracellular
YIL001W_p	YIL001W	YIL001W	hom	Uncharacterized	0.972665699960469	0.165359738901001	no	891	0.181867867994756	602	NA					Putative protein of unknown function; contains a BTB/POZ domain which generally function in protein interactions; deletion slightly improved competitive fitness in rich media; GFP-tagged protein is localized to the cytoplasm	biological_process	molecular_function	cytoplasm
YHR132W-A	YHR132W-A	IGO2	hom	Verified	0.972663985013877	0.165360165208211	no	892	0.172867581744941	556	NA	FT		NUCLEUS		Protein required for initiation of G0 program; prevents degradation of nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway; phosphorylated by Rim15p; GFP protein localizes to the cytoplasm and nucleus; similar to Igo1p	mRNA stabilization	molecular_function	nucleus|cytoplasm
YPL119C	YPL119C	DBP1	hom	Verified	0.972460481392609	0.165410757873834	no	893	0.146151366830384	508	NA	FT	TRANSLATION			Putative ATP-dependent RNA helicase of the DEAD-box protein family; mutants show reduced stability of the 40S ribosomal subunit scanning through 5' untranslated regions of mRNAs; protein abundance increases in response to DNA replication stress	translational initiation	RNA helicase activity	cytoplasm
YIL112W	YIL112W	HOS4	hom	Verified	0.970822328293245	0.165818380853622	no	894	0.147752211121231	538	NA	FT	CELL CYCLE|CHROMATIN ORGANIZATION	NUCLEUS|CHROMOSOME		Subunit of the Set3 complex, which is a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity; potential Cdc28p substrate	negative regulation of meiosis|histone deacetylation	molecular_function	Set3 complex
YPL184C	YPL184C	MRN1	hom	Verified	0.970642255103207	0.165863228192603	no	895	0.168681773854475	624	NA	FT	TRANSLATION			RNA-binding protein that may be involved in translational regulation; binds specific categories of mRNAs, including those that contain upstream open reading frames (uORFs) and internal ribosome entry sites (IRES); interacts genetically with chromatin remodelers and splicing factors, linking chromatin state, splicing and as a result mRNA maturation	biological_process	molecular_function	cytoplasm
YLL019C	YLL019C	KNS1	hom	Verified	0.970135464455381	0.165989486793465	no	896	0.138310018426245	479	NA	FT	PROTEIN PHOSPHORYLATION			Protein kinase involved in negative regulation of PolIII transcription; effector kinase of the TOR signaling pathway and phosphorylates Rpc53p to regulate ribosome and tRNA biosynthesis; member of the LAMMER family of protein kinases, which are serine/threonine kinases also capable of phosphorylating tyrosine residues; capable of autophosphorylation	negative regulation of transcription from RNA polymerase III promoter|protein autophosphorylation|protein phosphorylation	protein serine/threonine kinase activity|protein tyrosine kinase activity|protein kinase activity	nucleus|cytoplasm
YBR175W	YBR175W	SWD3	hom	Verified	0.969804359809395	0.166072009635464	no	897	0.162879024763996	572	NA	FT	CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS|CHROMOSOME		Essential subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member and ortholog of mammalian WDR5	histone H3-K4 methylation|telomere maintenance|chromatin silencing at telomere	histone methyltransferase activity (H3-K4 specific)	Set1C/COMPASS complex
YFL012W_p	YFL012W	YFL012W	hom	Uncharacterized	0.968961525753586	0.166282192914874	no	898	0.189750215939833	653	NA					Putative protein of unknown function; transcribed during sporulation; null mutant exhibits increased resistance to rapamycin	biological_process	molecular_function	cellular_component
YML124C	YML124C	TUB3	hom	Verified	0.966988758054883	0.166774826803061	no	899	0.243996412672063	871	NA	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|NUCLEOTIDE METABOLISM|CHROMOSOME SEGREGATION	NUCLEUS|CYTOSKELETON		Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; expressed at lower level than Tub1p; TUB3 has a paralog, TUB1, that arose from the whole genome duplication	nuclear migration along microtubule|nuclear migration involved in conjugation with cellular fusion|homologous chromosome segregation|mitotic sister chromatid segregation	structural constituent of cytoskeleton	tubulin complex|cytoplasmic microtubule|kinetochore microtubule|nuclear microtubule|spindle pole body|polar microtubule
YIL035C	YIL035C	CKA1	hom	Verified	0.965890994817084	0.167049364454292	no	900	0.172930887645986	629	NA	FT	RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION	NUCLEUS		Alpha catalytic subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases; regulates Fkh1p-mediated donor preference during mating-type switching	regulation of transcription from RNA polymerase I promoter|protein phosphorylation|regulation of transcription from RNA polymerase III promoter|response to DNA damage stimulus	protein serine/threonine kinase activity|protein kinase activity	protein kinase CK2 complex|UTP-C complex
YDL054C	YDL054C	MCH1	hom	Verified	0.965873895294856	0.167053643147087	no	901	0.173217758482906	594	NA					Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport	transport	monocarboxylic acid transmembrane transporter activity|transporter activity	integral to membrane|membrane
YLR381W	YLR381W	CTF3	hom	Verified	0.964067346156223	0.167506081292798	no	902	0.142770384545615	516	NA	FT	CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME	KINETOCHORE	Outer kinetochore protein that forms a complex with Mcm16p and Mcm22p; may bind the kinetochore to spindle microtubules; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-I and fission yeast mis6	chromosome segregation|DNA replication initiation|establishment of mitotic sister chromatid cohesion	molecular_function	condensed nuclear chromosome kinetochore
YOL132W	YOL132W	GAS4	hom	Verified	0.963787709894812	0.167576184813669	no	903	0.154599844744912	535	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	PLASMA MEMBRANE		1,3-beta-glucanosyltransferase, involved with Gas2p in spore wall assembly; has similarity to Gas1p; localizes to the cell wall	ascospore wall assembly	1,3-beta-glucanosyltransferase activity	fungal-type cell wall|integral to membrane
YJR096W	YJR096W	YJR096W	hom	Verified	0.963751222069263	0.167585333536913	no	904	0.158443057889934	555	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		Putative xylose and arabinose reductase; member of the aldo-keto reductase (AKR) family; GFP-fusion protein is induced in response to the DNA-damaging agent MMS	cellular response to oxidative stress|D-xylose catabolic process|arabinose catabolic process	alditol:NADP+ 1-oxidoreductase activity|aldo-keto reductase (NADP) activity	nucleus|cytoplasm
YOR081C	YOR081C	TGL5	hom	Verified	0.963404161723842	0.16767236930427	no	905	0.147080276090618	490	NA	FT	LIPID METABOLISM			Bifunctional enzyme with triacylglycerol lipase and lysophosphatidic acid acyltransferase activity; involved in triacylglycerol mobilization; localizes to lipid particles; potential Cdc28p substrate	triglyceride mobilization	lysophosphatidic acid acyltransferase activity|triglyceride lipase activity	lipid particle
YHR078W_p	YHR078W	YHR078W	hom	Uncharacterized	0.962854282382139	0.167810327594138	no	906	0.155182162497798	516	NA					High osmolarity-regulated gene of unknown function	biological_process	molecular_function	integral to membrane
YNL322C	YNL322C	KRE1	hom	Verified	0.961259058356391	0.168210964041398	no	907	0.18201064729975	668	NA	FT	CELL WALL ORG/BIOGENESIS	PLASMA MEMBRANE		Cell wall glycoprotein involved in beta-glucan assembly; serves as a K1 killer toxin membrane receptor	fungal-type cell wall organization	structural constituent of cell wall	fungal-type cell wall|integral to membrane
YBL049W	YBL049W	MOH1	hom	Verified	0.960230598459334	0.168469585092569	no	908	0.194989603304297	709	NA					Protein of unknown function, has homology to kinase Snf7p; not required for growth on nonfermentable carbon sources; essential for survival in stationary phase	biological_process	molecular_function	cellular_component
YOL054W	YOL054W	PSH1	hom	Verified	0.959700753896923	0.168602921871651	no	909	0.178223327781537	604	NA	FT	PROTEOLYSIS	NUCLEUS|CHROMOSOME		E3 ubiquitin ligase that mediates poyubiquitination and degradation of centromere-binding protein Cse4p and prevents Cse4p from mislocalizing to euchromatin; ubiquitylation of Cse4p may be antagonized by Scm3p	protein ubiquitination involved in ubiquitin-dependent protein catabolic process	ubiquitin-protein ligase activity	chromosome, centromeric region|nucleus
YKL167C	YKL167C	MRP49	hom	Verified	0.95930486953451	0.168702591479845	no	910	0.175551850351466	573	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit, not essential for mitochondrial translation	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YML101C	YML101C	CUE4	hom	Verified	0.956499990565461	0.16940984456741	no	911	0.11196674816869	378	NA	FT		ENDOPLASMIC RETICULUM		Protein of unknown function; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination; CUE4 has a paralog, CUE1, that arose from the whole genome duplication	biological_process	molecular_function	endoplasmic reticulum|cytoplasm
YHR116W	YHR116W	COX23	hom	Verified	0.956499373421028	0.169410000390096	no	912	0.165258443137294	558	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial intermembrane space protein that functions in mitochondrial copper homeostasis, essential for functional cytochrome oxidase expression; homologous to Cox17p; contains twin cysteine-x9-cysteine motifs	mitochondrial respiratory chain complex assembly	molecular_function	mitochondrion|cytoplasm
YOR105W_p	YOR105W	YOR105W	hom	Uncharacterized	0.955348085645714	0.169700848965749	no	913	0.163957918038341	565	NA					Protein of unknown function; expressed at both mRNA and protein levels	biological_process	molecular_function	cellular_component
YGR209C	YGR209C	TRX2	hom	Verified	0.949944188109686	0.171070306200582	no	914	0.146648680983632	461	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|RESPONSE TO OXIDATIVE STRESS	ENDOMEMBRANE SYSTEM|NUCLEUS|GOLGI APPARATUS		Cytoplasmic thioredoxin isoenzyme; part of the thioredoxin system which protects cells against oxidative and reductive stress; forms LMA1 complex with Pbi2p; acts as a cofactor for Tsa1p; required for ER-Golgi transport and vacuole inheritance; protein abundance increases in response to DNA replication stress	vacuole inheritance|regulation of DNA replication|cell redox homeostasis|protein deglutathionylation|sulfate assimilation|retrograde vesicle-mediated transport, Golgi to ER|cellular response to oxidative stress|ER to Golgi vesicle-mediated transport|vacuole fusion, non-autophagic	disulfide oxidoreductase activity	cytosol|fungal-type vacuole
YKL185W	YKL185W	ASH1	hom	Verified	0.949702742789613	0.171131657858108	no	915	0.128068249979977	472	NA	FT	CHROMATIN ORGANIZATION	NUCLEUS|CHROMOSOME		Zinc-finger inhibitor of HO transcription; mRNA is localized and translated in the distal tip of anaphase cells, resulting in accumulation of Ash1p in daughter cell nuclei and inhibition of HO expression; potential Cdc28p substrate	Unknown	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|core promoter proximal region sequence-specific DNA binding	Rpd3L-Expanded complex|nucleus|cellular bud|Rpd3L complex
YER067W	YER067W	RGI1	hom	Verified	0.94960975588587	0.171155289737781	no	916	0.142299265066423	480	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS|PLASMA MEMBRANE		Protein of unknown function; involved in energy metabolism under respiratory conditions; protein abundance is increased upon intracellular iron depletion; protein abundance increases in response to DNA replication stress	energy reserve metabolic process	molecular_function	cell periphery|nucleus|cytoplasm
YKR021W	YKR021W	ALY1	hom	Verified	0.949589638177215	0.171160402767504	no	917	0.166219052615079	575	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION			Alpha arrestin that controls nutrient-mediated intracellular sorting of permease Gap1p; interacts with AP-1 subunit Apl4p; may regulate endocytosis of plasma membrane proteins by recruiting ubiquitin ligase Rsp5p to plasma membrane targets; ALY1 has a paralog, ALY2, that arose from the whole genome duplication	Unknown|regulation of intracellular transport|ubiquitin-dependent endocytosis	ubiquitin protein ligase binding	late endosome|cytoplasm|early endosome
YOR363C	YOR363C	PIP2	hom	Verified	0.949481784153995	0.171187816144598	no	918	0.167566945906124	573	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS	NUCLEUS		Autoregulatory oleate-specific transcriptional activator of peroxisome proliferation, contains Zn(2)-Cys(6) cluster domain, forms heterodimer with Oaf1p, binds oleate response elements (OREs), activates beta-oxidation genes; PIP2 has a paralog, OAF1, that arose from the whole genome duplication	cellular response to oleic acid|positive regulation of fatty acid beta-oxidation|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	integral to membrane|nucleus
YOR068C	YOR068C	VAM10	hom	Verified	0.948877992170172	0.171341334475003	no	919	0.17943864296991	645	NA	FT	MEMBRANE ORGANIZATION			Protein involved in vacuole morphogenesis; acts at an early step of homotypic vacuole fusion that is required for vacuole tethering	vacuole fusion, non-autophagic	molecular_function	fungal-type vacuole membrane
YKL129C	YKL129C	MYO3	hom	Verified	0.94801014648944	0.171562144407825	no	920	0.126501699227007	428	NA	FT	VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS|CELL DIVISION	CYTOSKELETON		One of two type I myosins; localizes to actin cortical patches; deletion of MYO3 has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization	bipolar cellular bud site selection|fungal-type cell wall organization|endocytosis|exocytosis|actin cortical patch localization|response to osmotic stress	microfilament motor activity	actin cortical patch
YOL154W	YOL154W	ZPS1	hom	Verified	0.947319745245425	0.171737936144778	no	921	0.14253767800833	486	NA					Putative GPI-anchored protein; transcription is induced under low-zinc conditions, as mediated by the Zap1p transcription factor, and at alkaline pH	biological_process	molecular_function	fungal-type cell wall|fungal-type vacuole
YER049W	YER049W	TPA1	hom	Verified	0.946860546893466	0.171854922095648	no	922	0.147963314668409	481	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|OXIDATION-REDUCTION PROCESS	NUCLEUS		Poly(rA)-binding protein involved in translation termination efficiency, mRNA poly(A) tail length and mRNA stability; interacts with Sup45p (eRF1), Sup35p (eRF3) and Pab1p; similar to prolyl 4-hydroxylases; binds Fe(III) and 2-oxoglutarate	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|translational termination	poly(A) RNA binding	nucleus
YGL164C	YGL164C	YRB30	hom	Verified	0.945243923623493	0.172267179899446	no	923	0.168693122816154	585	NA	FT	PROTEIN LOCALIZATION	NUCLEUS		RanGTP-binding protein, inhibits RanGAP1 (Rna1p)-mediated GTP hydrolysis of RanGTP (Gsp1p); shares similarity to proteins in other fungi but not in higher eukaryotes	biological_process	GTPase regulator activity	nucleus|cytoplasm
YOR193W	YOR193W	PEX27	hom	Verified	0.944760970001074	0.172390461020277	no	924	0.167504741137328	546	NA	FT	PEROXISOME ORGANIZATION			Peripheral peroxisomal membrane protein involved in controlling peroxisome size and number, interacts with homologous protein Pex25p	peroxisome organization	molecular_function	peroxisomal membrane
YKL100C_p	YKL100C	YKL100C	hom	Uncharacterized	0.943572016423595	0.172694198911492	no	925	0.142457644406463	473	NA	FT	PROTEOLYSIS			Putative protein of unknown function with similarity to a human minor histocompatibility antigen and signal peptide peptidases; YKL100C is not an essential gene	biological_process	molecular_function	integral to membrane
YOR324C	YOR324C	FRT1	hom	Verified	0.942403148230335	0.172993138011485	no	926	0.18237581817901	605	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Tail-anchored ER membrane protein of unknown function; substrate of the phosphatase calcineurin; interacts with homolog Frt2p; promotes cell growth in stress conditions, possibly via a role in posttranslational translocation; FRT1 has a paralog, FRT2, that arose from the whole genome duplication	response to stress	molecular_function	endoplasmic reticulum
YDR514C	YDR514C	YDR514C	hom	Verified	0.94124169784956	0.173290506345868	no	927	0.165218782176499	582	NA	FT		NUCLEUS|MITOCHONDRION		Protein of unknown function that localizes to mitochondria; overexpression affects endocytic protein trafficking; YDR514C has a paralog, GFD2, that arose from the whole genome duplication	biological_process	molecular_function	mitochondrion|nucleus
YBR221C	YBR221C	PDB1	hom	Verified	0.940265627453555	0.17354066302703	no	928	0.152211410352408	522	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		E1 beta subunit of the pyruvate dehydrogenase (PDH) complex, which is an evolutionarily-conserved multi-protein complex found in mitochondria	acetyl-CoA biosynthetic process from pyruvate	pyruvate dehydrogenase (acetyl-transferring) activity	mitochondrial nucleoid|mitochondrion|mitochondrial pyruvate dehydrogenase complex
YJL082W	YJL082W	IML2	hom	Verified	0.939078338350194	0.173845262486275	no	929	0.162097200179487	568	NA	FT		NUCLEUS|MITOCHONDRION		Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; IML2 has a paralog, YKR018C, that arose from the whole genome duplication	biological_process	molecular_function	mitochondrial outer membrane|mitochondrion|nucleus|cytoplasm
YNL300W_p	YNL300W	TOS6	hom	Uncharacterized	0.936996475823942	0.174380185359282	no	930	0.193788546110658	689	NA					Glycosylphosphatidylinositol-dependent cell wall protein, expression is periodic and decreases in respone to ergosterol perturbation or upon entry into stationary phase; depletion increases resistance to lactic acid	biological_process	molecular_function	fungal-type cell wall
YPL189W	YPL189W	GUP2	hom	Verified	0.936923631684513	0.17439892116576	no	931	0.122556681997041	415	NA					Probable membrane protein with a possible role in proton symport of glycerol; member of the MBOAT family of putative membrane-bound O-acyltransferases; Gup1p homolog	glycerol transport	O-acyltransferase activity	integral to membrane|membrane
YGR004W	YGR004W	PEX31	hom	Verified	0.936491639384923	0.174510057605315	no	932	0.144250862170084	498	NA	FT	PEROXISOME ORGANIZATION			Peroxisomal integral membrane protein, involved in negative regulation of peroxisome size; partially functionally redundant with Pex30p and Pex32p; probably acts at a step downstream of steps mediated by Pex28p and Pex29p	peroxisome organization	molecular_function	integral to membrane|integral to peroxisomal membrane
YBL051C	YBL051C	PIN4	hom	Verified	0.936413572336106	0.174530146311643	no	933	0.195433739859733	680	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE			Protein involved in G2/M phase progression and response to DNA damage, interacts with Rad53p; contains an RNA recognition motif, a nuclear localization signal, and several SQ/TQ cluster domains; hyperphosphorylated in response to DNA damage	G2/M transition of mitotic cell cycle|DNA damage checkpoint	molecular_function	cytoplasm
YER078C	YER078C	ICP55	hom	Verified	0.936156344978318	0.174596348072327	no	934	0.17268730996128	609	NA	FT	PROTEOLYSIS	NUCLEUS|MITOCHONDRION		Mitochondrial aminopeptidase; cleaves the N termini of at least 38 imported proteins after cleavage by the mitochondrial processing peptidase (MPP), thereby increasing their stability; member of the aminopeptidase P family	protein stabilization|protein processing	aminopeptidase activity	extrinsic to mitochondrial inner membrane|mitochondrion|nucleus
YDR501W	YDR501W	PLM2	hom	Verified	0.934883677554759	0.174924124883483	no	935	0.151208607675327	497	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Putative transcription factor, contains Forkhead Associated domain; found associated with chromatin; target of SBF transcription factor; induced in response to DNA damaging agents and deletion of telomerase; PLM2 has a paralog, TOS4, that arose from the whole genome duplication	response to DNA damage stimulus	chromatin binding	nuclear chromatin
YER103W	YER103W	SSA4	hom	Verified	0.934303887095233	0.175073579900439	no	936	0.158510064065939	582	NA	FT	PROTEIN LOCALIZATION	NUCLEUS		Heat shock protein that is highly induced upon stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the HSP70 family; cytoplasmic protein that concentrates in nuclei upon starvation; SSA4 has a paralog, SSA3, that arose from the whole genome duplication	protein folding|SRP-dependent cotranslational protein targeting to membrane, translocation|response to stress	unfolded protein binding|ATPase activity	nucleus|cytoplasm
YMR056C	YMR056C	AAC1	hom	Verified	0.933359870437561	0.175317096298878	no	937	0.163911073285864	592	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Mitochondrial inner membrane ADP/ATP translocator; exchanges cytosolic ADP for mitochondrially synthesized ATP; phosphorylated; Aac1p is a minor isoform while Pet9p is the major ADP/ATP translocator; relocalizes from mitochondrion to cytoplasm upon DNA replication stress	heme biosynthetic process|mitochondrial transport|heme transport|aerobic respiration	ATP:ADP antiporter activity	mitochondrion|integral to membrane|mitochondrial inner membrane
YGL051W	YGL051W	MST27	hom	Verified	0.931847275597541	0.175707729351215	no	938	0.145907930414469	483	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS|PLASMA MEMBRANE		Putative integral membrane protein, involved in vesicle formation; forms complex with Mst28p; member of DUP240 gene family; binds COPI and COPII vesicles	vesicle organization	molecular_function	integral to membrane|Golgi apparatus|endoplasmic reticulum|plasma membrane
YDL223C	YDL223C	HBT1	hom	Verified	0.931275438710099	0.175855551813246	no	939	0.207286176202058	726	NA					Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis	cell morphogenesis involved in conjugation with cellular fusion	molecular_function	plasma membrane|mating projection
YNL253W	YNL253W	TEX1	hom	Verified	0.931043133147653	0.175915626360377	no	940	0.163610236506902	519	NA	FT	RNA LOCALIZATION	NUCLEUS		Protein involved in mRNA export, component of the transcription export (TREX) complex	mRNA export from nucleus	molecular_function	transcription export complex
YMR244W_p	YMR244W	YMR244W	hom	Uncharacterized	0.930928160867527	0.175945363161868	no	941	0.138636356864659	495	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YPL221W	YPL221W	FLC1	hom	Verified	0.930886069387978	0.17595625063389	no	942	0.167807695753086	584	NA	FT	CELL WALL ORG/BIOGENESIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|SITE OF POLARIZED GROWTH		Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance	protein folding|fungal-type cell wall biogenesis|FAD transport	FAD transmembrane transporter activity	integral to membrane|endoplasmic reticulum|fungal-type vacuole|cellular bud neck
YAL051W	YAL051W	OAF1	hom	Verified	0.927910737363425	0.17672693710384	no	943	0.1644164356447	538	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|GENE SILENCING	NUCLEUS		Oleate-activated transcription factor; acts alone and as a heterodimer with Pip2p; activates genes involved in beta-oxidation of fatty acids and peroxisome organization and biogenesis; OAF1 has a paralog, PIP2, that arose from the whole genome duplication	cellular response to oleic acid|positive regulation of fatty acid beta-oxidation|positive regulation of chromatin silencing at telomere|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YJL062W-A	YJL062W-A	COA3	hom	Verified	0.925353239591808	0.177391096804599	no	944	0.165835743652952	577	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial inner membrane protein that participates in regulation of COX1 translation, Cox1p stabilization, and cytochrome oxidase assembly	mitochondrial respiratory chain complex IV assembly|negative regulation of mitochondrial translation	molecular_function	mitochondrion|mitochondrial inner membrane|integral to mitochondrial inner membrane
YOL151W	YOL151W	GRE2	hom	Verified	0.924320918831776	0.177659627266743	no	945	0.138648420646222	462	NA	FT	LIPID METABOLISM|OXIDATION-REDUCTION PROCESS	NUCLEUS		3-methylbutanal reductase and NADPH-dependent methylglyoxal reductase (D-lactaldehyde dehydrogenase); stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway; protein abundance increases in response to DNA replication stress	ergosterol metabolic process|filamentous growth	methylglyoxal reductase (NADPH-dependent) activity|3-methylbutanol:NAD(P) oxidoreductase activity	nucleus|cytoplasm
YBL031W	YBL031W	SHE1	hom	Verified	0.924036472568443	0.177733663357715	no	946	0.174535359411962	634	NA	FT	CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION	NUCLEUS|SITE OF POLARIZED GROWTH|CYTOSKELETON		Mitotic spindle protein; interacts with components of the Dam1 (DASH) complex, its effector Sli15p, and microtubule-associated protein Bim1p; also localizes to nuclear microtubules and to the bud neck in a ring-shaped structure; inhibits dynein function	mitotic spindle elongation	molecular_function	microtubule cytoskeleton|nuclear microtubule|cellular bud neck|astral microtubule|spindle
YMR039C	YMR039C	SUB1	hom	Verified	0.921564228080198	0.178377962356646	no	947	0.165023296637079	543	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Transcriptional coactivator; facilitates elongation through factors that modify RNAP II; role in peroxide resistance involving Rad2p; role in the hyperosmotic stress response through polymerase recruitment at RNAP II and RNAP III genes; protein abundance increases in response to DNA replication stress	termination of RNA polymerase II transcription|hyperosmotic response|RNA polymerase III transcriptional preinitiation complex assembly|positive regulation of transcription elongation from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter in response to stress|positive regulation of transcription from RNA polymerase III promoter	transcription coactivator activity	nucleus
YLR377C	YLR377C	FBP1	hom	Verified	0.920824968964697	0.178570908328006	no	948	0.183071407073388	642	NA	FT	CARBOHYDRATE METABOLISM			Fructose-1,6-bisphosphatase, key regulatory enzyme in the gluconeogenesis pathway, required for glucose metabolism; undergoes either proteasome-mediated or autophagy-mediated degradation depending on growth conditions; interacts with Vid30p	gluconeogenesis|reactive oxygen species metabolic process	fructose 1,6-bisphosphate 1-phosphatase activity	cytosol
YOR289W_p	YOR289W	YOR289W	hom	Uncharacterized	0.920260253292111	0.178718387135203	no	949	0.161877079554302	542	NA	FT		NUCLEUS		Putative protein of unknown function; transcription induced by the unfolded protein response; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus	biological_process	molecular_function	nucleus|cytoplasm
YGR285C	YGR285C	ZUO1	hom	Verified	0.919909884787978	0.178809926460849	no	950	0.178844809451071	644	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION	NUCLEUS|MITOCHONDRION	RIBOSOME	Ribosome-associated chaperone, functions in ribosome biogenesis and, in partnership with Ssz1p and SSb1/2, as a chaperone for nascent polypeptide chains; contains a DnaJ domain and functions as a J-protein partner for Ssb1p and Ssb2p	protein folding|ribosomal subunit export from nucleus|rRNA processing|regulation of translational fidelity	unfolded protein binding	mitochondrion|ribosome|nucleolus|polysome|cytoplasm
YDR500C	YDR500C	RPL37B	hom	Verified	0.919793277904417	0.178840398402329	no	951	0.160226158708592	558	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L37B; protein abundance increases in response to DNA replication stress; homologous to mammalian ribosomal protein L37, no bacterial homolog; RPL37B has a paralog, RPL37A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YIR014W_p	YIR014W	YIR014W	hom	Uncharacterized	0.919325003933691	0.178962801599538	no	952	0.161494990238098	536	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p; YIR014W is a non-essential gene	biological_process	molecular_function	fungal-type vacuole
YER089C	YER089C	PTC2	hom	Verified	0.919132483111555	0.179013140343582	no	953	0.143397991927589	485	NA	FT	CELL CYCLE|SIGNALING|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION	NUCLEUS		Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p to limit maximal osmostress induced kinase activity; dephosphorylates Ire1p to downregulate the unfolded protein response; dephosphorylates Cdc28p; inactivates the DNA damage checkpoint; PTC2 has a paralog, PTC3, that arose from the whole genome duplication	endoplasmic reticulum unfolded protein response|inactivation of MAPK activity involved in osmosensory signaling pathway|regulation of cyclin-dependent protein kinase activity|protein dephosphorylation|DNA damage checkpoint	protein serine/threonine phosphatase activity	nucleus|cytoplasm
YMR036C	YMR036C	MIH1	hom	Verified	0.91481435060536	0.180144549886029	no	954	0.146673797195846	502	NA	FT	CELL CYCLE|CELL DIVISION|PROTEIN PHOSPHORYLATION	NUCLEUS		Protein tyrosine phosphatase involved in cell cycle control; regulates the phosphorylation state of Cdc28p; homolog of S. pombe cdc25	G2/M transition of mitotic cell cycle|regulation of cyclin-dependent protein kinase activity	protein tyrosine phosphatase activity	nucleus|cytoplasm
YNL013C_d	YNL013C	YNL013C	hom	Dubious	0.914794796659545	0.180149683474188	no	955	0.151524005358305	515	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF HEF3/YNL014W	Unknown	Unknown	Unknown
YLR262C-A	YLR262C-A	TMA7	hom	Verified	0.914541511186271	0.180216187983591	no	956	0.168611249279915	614	NA	FT	TRANSLATION	NUCLEUS		Protein of unknown that associates with ribosomes; null mutant exhibits translation defects, altered polyribosome profiles, and resistance to the translation inhibitor anisomcyin; protein abundance increases in response to DNA replication stress	cytoplasmic translation	molecular_function	nucleus|cytoplasm
YLR130C	YLR130C	ZRT2	hom	Verified	0.913278989301182	0.180547914863284	no	957	0.172965330840029	578	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Low-affinity zinc transporter of the plasma membrane; transcription is induced under low-zinc conditions by the Zap1p transcription factor	low-affinity zinc ion transport	low-affinity zinc ion transmembrane transporter activity	integral to membrane|plasma membrane
YOR351C	YOR351C	MEK1	hom	Verified	0.91283308350135	0.180665167807921	no	958	0.166868850553566	596	NA	FT	CELL CYCLE|PROTEIN PHOSPHORYLATION	NUCLEUS		Meiosis-specific serine/threonine protein kinase, functions in meiotic checkpoint, promotes recombination between homologous chromosomes by suppressing double strand break repair between sister chromatids	meiosis|meiotic recombination checkpoint|protein phosphorylation	protein serine/threonine kinase activity|protein kinase activity	nucleus
YFR056C_d	YFR056C	YFR056C	hom	Dubious	0.910621955828257	0.181247298989976	no	959	0.172484800453936	589	NA					Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W	Unknown	Unknown	Unknown
YMR255W	YMR255W	GFD1	hom	Verified	0.907237785948474	0.182140532958234	no	960	0.173165282401082	607	NA	FT	PROTEIN LOCALIZATION|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	Coiled-coiled protein of unknown function; identified as a high-copy suppressor of a dbp5 mutation; protein abundance increases in response to DNA replication stress	mRNA export from nucleus	molecular_function	integral to membrane|nuclear pore|cytoplasm
YOR288C	YOR288C	MPD1	hom	Verified	0.906875263932331	0.18223638165787	no	961	0.161881899407178	553	NA	FT		ENDOPLASMIC RETICULUM		Member of the protein disulfide isomerase (PDI) family; interacts with and inhibits the chaperone activity of Cne1p; MPD1 overexpression in a pdi1 null mutant suppresses defects in Pdi1p functions such as carboxypeptidase Y maturation	protein folding	protein disulfide oxidoreductase activity|protein disulfide isomerase activity	fungal-type vacuole
YIL020C	YIL020C	HIS6	hom	Verified	0.905304289483752	0.182652102291275	no	962	0.182868331960532	616	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Phosphoribosyl-5-amino-1-phosphoribosyl-4-imidazolecarboxiamide isomerase, catalyzes the fourth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts	histidine biosynthetic process	1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity	intracellular
YOR366W_d	YOR366W	YOR366W	hom	Dubious	0.904143463752898	0.182959667054736	no	963	0.191882846366962	666	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR365C	Unknown	Unknown	Unknown
YOR076C	YOR076C	SKI7	hom	Verified	0.903207486567018	0.183207892622452	no	964	0.19250417045571	655	NA	FT	TRANSLATION|NUCLEOTIDE METABOLISM			Coupling protein that mediates interactions between the Ski complex and the cytoplasmic exosome during 3'-5' RNA degradation; eRF3-like domain targets nonstop mRNA for degradation; null mutants have superkiller phenotype	nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'|nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay|nuclear-transcribed mRNA catabolic process, non-stop decay|nonfunctional rRNA decay	protein binding, bridging	Ski complex|cytoplasmic exosome (RNase complex)|cytoplasm
YJL215C_d	YJL215C	YJL215C	hom	Dubious	0.902325013877292	0.183442120821877	no	965	0.198065375445706	649	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YOR275C	YOR275C	RIM20	hom	Verified	0.901151803318057	0.183753806336881	no	966	0.176078693105258	635	NA	FT	ION HOMEOSTASIS|PROTEOLYSIS|ION HOMEOSTASIS	NUCLEUS		Protein involved in proteolytic activation of Rim101p in response to alkaline pH; PalA/AIP1/Alix family member; interaction with the ESCRT-III subunit Snf7p suggests a relationship between pH response and multivesicular body formation	proteolysis|response to pH|protein processing|invasive growth in response to glucose limitation|sporulation resulting in formation of a cellular spore	molecular_function	nucleus|cytoplasm
YLL063C	YLL063C	AYT1	hom	Verified	0.899886078381794	0.184090439762977	no	967	0.152470244381308	498	NA					Acetyltransferase; catalyzes trichothecene 3-O-acetylation, suggesting a possible role in trichothecene biosynthesis	secondary metabolic process	trichothecene 3-O-acetyltransferase activity	cellular_component
YLR251W	YLR251W	SYM1	hom	Verified	0.899790966894489	0.184115751204748	no	968	0.171140997132636	566	NA	FT		MITOCHONDRION		Protein required for ethanol metabolism; induced by heat shock and localized to the inner mitochondrial membrane; homologous to mammalian peroxisomal membrane protein Mpv17	ethanol metabolic process	molecular_function	mitochondrion|integral to membrane|mitochondrial inner membrane
YIL121W	YIL121W	QDR2	hom	Verified	0.898360688401038	0.184496643723946	no	969	0.1661201256865	557	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; exports copper; has broad substrate specificity and can transport many mono- and divalent cations; transports a variety of drugs and is required for resistance to quinidine, barban, cisplatin, and bleomycin; contributes to potassium homeostasis; expression is regulated by copper	drug transmembrane transport|potassium ion import	drug transmembrane transporter activity	integral to membrane|integral to plasma membrane
YMR092C	YMR092C	AIP1	hom	Verified	0.898171640399561	0.184547025089434	no	970	0.172987814707533	584	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION	NUCLEUS|SITE OF POLARIZED GROWTH|CYTOSKELETON		Actin cortical patch component; interacts with the actin depolymerizing factor cofilin; required to restrict cofilin localization to cortical patches; contains WD repeats; protein increases in abundance and relocalizes from cytoplasm to plasma membrane upon DNA replication stress	actin filament depolymerization|response to osmotic stress	actin binding	nucleus|mating projection tip|cytoplasm|actin cortical patch
YKR069W	YKR069W	MET1	hom	Verified	0.897947763112654	0.18460669953778	no	971	0.185269573684168	630	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM			S-adenosyl-L-methionine uroporphyrinogen III transmethylase, involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis	siroheme biosynthetic process|methionine biosynthetic process|sulfate assimilation	uroporphyrin-III C-methyltransferase activity	intracellular
YMR120C	YMR120C	ADE17	hom	Verified	0.897233503546134	0.184797165485214	no	972	0.160834974290204	584	NA	FT	NUCLEOTIDE METABOLISM			Enzyme of 'de novo' purine biosynthesis; contains both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities; ADE17 has a paralog, ADE16, that arose from the whole genome duplication; ade16 ade17 mutants require adenine and histidine	purine nucleotide biosynthetic process|'de novo' IMP biosynthetic process	phosphoribosylaminoimidazolecarboxamide formyltransferase activity|IMP cyclohydrolase activity	cytosol|plasma membrane
YER067C-A_d	YER067C-A	YER067C-A	hom	Dubious	0.894150098618107	0.185620793713366	no	973	0.153824264971441	498	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YER067W	Unknown	Unknown	Unknown
YDR333C	YDR333C	RQC1	hom	Verified	0.893634271726119	0.185758801633221	no	974	0.169168785473703	530	NA					Component of the ribosome quality control complex (RQC); RQC (Rqc1p-Ltn1p-Tae2p-Cdc48p-Npl4p-Ufd1p), is a ribosome-bound complex required for the degradation of polypeptides arising from stalled translation; required along with Ltn1p for recruitment of the Cdc48p-Npl4p-Ufd1p AAA ATPase complex to the RQC	biological_process	molecular_function	cytoplasm
YLR035C	YLR035C	MLH2	hom	Verified	0.893545530458344	0.185782550505428	no	975	0.185728482451469	627	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS		Protein involved in the mismatch repair of certain frameshift intermediates and involved in meiotic recombination; forms a complex with Mlh1p	mismatch repair|reciprocal meiotic recombination	molecular_function	nucleus
YER137C_p	YER137C	YER137C	hom	Uncharacterized	0.892903020061803	0.185954554836713	no	976	0.191851136541792	688	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YER052C	YER052C	HOM3	hom	Verified	0.892192134412983	0.186144978702322	no	977	0.189475189117641	675	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis	threonine biosynthetic process|methionine biosynthetic process|homoserine biosynthetic process	aspartate kinase activity	cytoplasm
YBL063W	YBL063W	KIP1	hom	Verified	0.891162281155517	0.186421058221972	no	978	0.161004347086509	515	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION	CYTOSKELETON		Kinesin-related motor protein required for mitotic spindle assembly, chromosome segregation, and 2 micron plasmid partitioning; functionally redundant with Cin8p for chromosomal but not plasmid functions	mitotic anaphase B|microtubule depolymerization|spindle pole body separation|plasmid partitioning|mitotic sister chromatid segregation	microtubule motor activity|structural constituent of cytoskeleton	spindle microtubule|kinesin complex|spindle pole body
YGL260W_p	YGL260W	YGL260W	hom	Uncharacterized	0.888129350043409	0.187235588289682	no	979	0.169956251192632	560	NA					Putative protein of unknown function; transcription is significantly increased in a NAP1 deletion background; deletion mutant has increased accumulation of nickel and selenium	biological_process	molecular_function	cellular_component
YOR385W_p	YOR385W	YOR385W	hom	Uncharacterized	0.887844864636965	0.187312102989089	no	980	0.189672939315945	687	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YOR385W is not an essential gene	biological_process	molecular_function	cytoplasm
YER016W	YER016W	BIM1	hom	Verified	0.88754462672815	0.187392875417519	no	981	0.182020048165234	653	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION	CHROMOSOME|CYTOSKELETON	KINETOCHORE	Microtubule-binding protein that together with Kar9p makes up the cortical microtubule capture site and delays the exit from mitosis when the spindle is oriented abnormally	nuclear migration along microtubule|microtubule nucleation|microtubule depolymerization|negative regulation of microtubule depolymerization|positive regulation of microtubule polymerization|mitotic sister chromatid cohesion|mitotic cell cycle spindle assembly checkpoint	microtubule plus-end binding|protein homodimerization activity|structural constituent of cytoskeleton	spindle midzone|microtubule plus end|cytoplasmic microtubule|spindle pole body|kinetochore|spindle pole|spindle
YGR130C	YGR130C	YGR130C	hom	Verified	0.887093642735595	0.18751424322755	no	982	0.211150385118254	730	NA					Component of the eisosome with unknown function; GFP-fusion protein localizes to the cytoplasm; specifically phosphorylated in vitro by mammalian diphosphoinositol pentakisphosphate (IP7)	biological_process	molecular_function	eisosome|membrane raft|cytoplasm
YDL009C_p	YDL009C	YDL009C	hom	Uncharacterized	0.886494663900647	0.187675514165006	no	983	0.184478927009482	628	NA					Protein of unknown function; mRNA identified as translated by ribosome profiling data; partially overlaps the verified ORF YDL010W; YDL009C is not an essential gene	biological_process	molecular_function	cellular_component
YER091C	YER091C	MET6	hom	Verified	0.885620876476912	0.187910929043434	no	984	0.1183450372684	418	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Cobalamin-independent methionine synthase, involved in methionine biosynthesis and regeneration; requires a minimum of two glutamates on the methyltetrahydrofolate substrate, similar to bacterial metE homologs	methionine biosynthetic process	5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity	plasma membrane|cytoplasm
YOR051C	YOR051C	ETT1	hom	Verified	0.884137319227173	0.188311044828532	no	985	0.176901478317917	622	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION	NUCLEUS		Nuclear protein that inhibits replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts; deletion increases stop codon readthrough	translational termination	molecular_function	nucleus
YLL049W	YLL049W	LDB18	hom	Verified	0.883917071591507	0.188370490449136	no	986	0.168167641477413	590	NA	FT	CELL CYCLE|CYTOSKELETON ORGANIZATION	CYTOSKELETON		Component of the dynactin complex, which is required for dynein activity; null mutant exhibits defects in nuclear migration and spindle orientation and has reduced affinity for alcian blue dye; has homology to mammalian dynactin subunit p24	establishment of mitotic spindle orientation	molecular_function	dynactin complex|cell cortex|spindle pole body|astral microtubule
YOR318C_d	YOR318C	YOR318C	hom	Dubious	0.882881042391319	0.188650273677232	no	987	0.181109251291225	640	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcript is predicted to be spliced but there is no evidence that it is spliced in vivo	Unknown	Unknown	Unknown
YGR136W	YGR136W	LSB1	hom	Verified	0.882798035203314	0.18867270113155	no	988	0.149271047826573	467	NA	FT		NUCLEUS		Protein containing an N-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein increases in abundance and forms nuclear foci in response to DNA replication stress	biological_process	molecular_function	nucleus|cytoplasm
YOL071W	YOL071W	EMI5	hom	Verified	0.882783814873974	0.188676543443066	no	989	0.150802081437814	496	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Subunit of succinate dehydrogenase, which couples succinate oxidation to ubiquinone reduction; required for FAD cofactor attachment to Sdh1p; mutations in human ortholog PGL2 are associated with neuroendocrine tumors (paraganglioma)	protein-FAD linkage|cellular respiration|mitochondrial electron transport, succinate to ubiquinone|ascospore formation|tricarboxylic acid cycle|positive regulation of transcription from RNA polymerase II promoter	succinate dehydrogenase (ubiquinone) activity	mitochondrial respiratory chain complex II|mitochondrion|mitochondrial matrix
YPR069C	YPR069C	SPE3	hom	Verified	0.881020094558905	0.189153471941681	no	990	0.222086366570625	782	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM	NUCLEUS		Spermidine synthase, involved in biosynthesis of spermidine and also in biosynthesis of pantothenic acid; spermidine is required for growth of wild-type cells	spermidine biosynthetic process|pantothenate biosynthetic process	spermidine synthase activity	nucleus|cytoplasm
YPR160W	YPR160W	GPH1	hom	Verified	0.880827985677129	0.189205464998559	no	991	0.158695050706711	537	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY			Non-essential glycogen phosphorylase required for the mobilization of glycogen, activity is regulated by cyclic AMP-mediated phosphorylation, expression is regulated by stress-response elements and by the HOG MAP kinase pathway	glycogen catabolic process	glycogen phosphorylase activity	cytoplasm
YNL316C	YNL316C	PHA2	hom	Verified	0.88042825843168	0.189313676856019	no	992	0.168756025545129	611	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Prephenate dehydratase, catalyzes the conversion of prephanate to phenylpyruvate, which is a step in the phenylalanine biosynthesis pathway	L-phenylalanine biosynthetic process	prephenate dehydratase activity	cytoplasm
YGR206W	YGR206W	MVB12	hom	Verified	0.8786128608021	0.189805610103123	no	993	0.180588382679716	613	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|VACUOLAR TRANSPORT			ESCRT-I subunit required to stabilize oligomers of the ESCRT-I core complex (Stp22p, Vps28p, Srn2p), which is involved in ubiquitin-dependent sorting of proteins into the endosome; deletion mutant is sensitive to rapamycin and nystatin	negative regulation of protein complex assembly|protein targeting to vacuole|endosome transport via multivesicular body sorting pathway	ubiquitin binding	cytosol|endosome|ESCRT I complex
YDL230W	YDL230W	PTP1	hom	Verified	0.878547382753094	0.189823367904052	no	994	0.165248964064838	533	NA	FT		MITOCHONDRION		Phosphotyrosine-specific protein phosphatase that dephosphorylates a broad range of substrates in vivo, including Fpr3p; localized to the cytoplasm and the mitochondria; proposed to be a negative regulator of filamentation	pseudohyphal growth|invasive growth in response to glucose limitation|protein dephosphorylation	protein tyrosine phosphatase activity	mitochondrion|cytoplasm
YLR369W	YLR369W	SSQ1	hom	Verified	0.875770187356507	0.190577490141045	no	995	0.187432592582661	625	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|COFACTOR METABOLISM	MITOCHONDRION		Mitochondrial hsp70-type molecular chaperone, required for assembly of iron/sulfur clusters into proteins at a step after cluster synthesis, and for maturation of Yfh1p, which is a homolog of human frataxin implicated in Friedreich's ataxia	iron-sulfur cluster assembly|intracellular sequestering of iron ion|protein maturation	unfolded protein binding	mitochondrion|mitochondrial matrix
YDL179W	YDL179W	PCL9	hom	Verified	0.875439829858627	0.190667317967179	no	996	0.197590387783854	681	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CELL DIVISION|PROTEIN PHOSPHORYLATION	SITE OF POLARIZED GROWTH		Cyclin, forms a functional kinase complex with Pho85p cyclin-dependent kinase (Cdk), expressed in late M/early G1 phase, activated by Swi5p	regulation of establishment or maintenance of cell polarity|regulation of transcription involved in G1/S phase of mitotic cell cycle	cyclin-dependent protein kinase regulator activity	cyclin-dependent protein kinase holoenzyme complex|incipient cellular bud site|cellular bud neck
YBL001C	YBL001C	ECM15	hom	Verified	0.875351863242029	0.190691241435334	no	997	0.173117041021278	560	NA	FT	CELL WALL ORG/BIOGENESIS	NUCLEUS		Non-essential protein of unknown function, likely exists as tetramer, may be regulated by the binding of small-molecule ligands (possibly sulfate ions), may have a role in yeast cell-wall biogenesis	fungal-type cell wall organization	molecular_function	nucleus|cytoplasm
YDR540C	YDR540C	IRC4	hom	Verified	0.875282867759525	0.190710006788504	no	998	0.233362050436119	828	NA	FF|FT		NUCLEUS		Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus	mitotic recombination	molecular_function	nucleus|cytoplasm
YER079W_p	YER079W	YER079W	hom	Uncharacterized	0.87443162315781	0.190941621062426	no	999	0.180995614859974	601	NA	FT		NUCLEUS		Putative protein of unknown function	biological_process	molecular_function	nucleus|cytoplasm
YNL286W	YNL286W	CUS2	hom	Verified	0.874136442855777	0.191021976643052	no	1000	0.194799232961661	655	NA	FT	RNA PROCESSING	NUCLEUS		Protein that binds to U2 snRNA and Prp11p, may be involved in U2 snRNA folding; contains two RNA recognition motifs (RRMs)	mRNA splicing, via spliceosome	RNA binding	U2 snRNP
YLR393W	YLR393W	ATP10	hom	Verified	0.872131200595148	0.191568403386757	no	1001	0.18670885534471	619	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial inner membrane protein required for assembly of the F0 sector of mitochondrial F1F0 ATP synthase, interacts genetically with ATP6	mitochondrial proton-transporting ATP synthase complex assembly	unfolded protein binding	integral to mitochondrial membrane|mitochondrion|mitochondrial inner membrane
YGR290W_d	YGR290W	YGR290W	hom	Dubious	0.871286091546165	0.19179898137498	no	1002	0.203136458868509	704	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; putative HLH protein; partially overlaps the verified ORF MAL11/YGR289C (a high-affinity maltose transporter)	Unknown	Unknown	Unknown
YDR246W-A_p	YDR246W-A	YDR246W-A	hom	Uncharacterized	0.870329548598285	0.19206016769352	no	1003	0.177549693569524	615	NA					Putative protein of unknown function; identified by fungal homology and RT-PCR	biological_process	molecular_function	cellular_component
YGL212W	YGL212W	VAM7	hom	Verified	0.870045945197017	0.192137648085399	no	1004	0.206605305152933	698	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION			Vacuolar SNARE protein; functions with Vam3p in vacuolar protein trafficking; has an N-terminal PX domain (phosphoinositide-binding module) that binds PtdIns-3-P and mediates membrane binding; SNAP-25 homolog; protein abundance increases in response to DNA replication stress	piecemeal microautophagy of nucleus|vacuole fusion, non-autophagic|vesicle fusion	SNAP receptor activity|phosphatidylinositol-3-phosphate binding	SNARE complex|fungal-type vacuole membrane
YKL163W	YKL163W	PIR3	hom	Verified	0.869893115266534	0.19217940911976	no	1005	0.173975658661981	570	NA	FT	CELL WALL ORG/BIOGENESIS			O-glycosylated covalently-bound cell wall protein; required for cell wall stability; expression is cell cycle regulated, peaking in M/G1 and also subject to regulation by the cell integrity pathway; PIR3 has a paralog, HSP150, that arose from the whole genome duplication	fungal-type cell wall organization	structural constituent of cell wall	fungal-type cell wall
YPR053C_d	YPR053C	YPR053C	hom	Dubious	0.868641425292966	0.192521644433832	no	1006	0.180400153789324	652	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene NHP6A/YPR052C	Unknown	Unknown	Unknown
YDR352W	YDR352W	YPQ2	hom	Verified	0.868441658734819	0.192576298779894	no	1007	0.164884635321629	553	NA					Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; member of the PQ-loop family, with seven transmembrane domains; mutant phenotype is functionally complemented by rat PQLC2 vacuolar transporter	biological_process	molecular_function	fungal-type vacuole membrane|integral to membrane
YBR069C	YBR069C	TAT1	hom	Verified	0.866763350992735	0.193035843220799	no	1008	0.355680426225519	1177	NA	FF|FT		PLASMA MEMBRANE		Amino acid transporter for valine, leucine, isoleucine, and tyrosine; low-affinity tryptophan and histidine transporter; overexpression confers FK506 and FTY720 resistance; protein abundance increases in response to DNA replication stress	amino acid transport|tyrosine transport|tryptophan transport|transmembrane transport	amino acid transmembrane transporter activity|low-affinity tryptophan transmembrane transporter activity	integral to membrane|plasma membrane
YFR008W	YFR008W	FAR7	hom	Verified	0.866182862977324	0.193194944789696	no	1009	0.198310252545708	711	NA	FT	CELL CYCLE|SIGNALING			Protein involved in recovery from pheromone-induced cell cycle arrest; acts in a Far1p-independent pathway; interacts with Far3p, Far8p, Far9p, Far10p, and Far11p; protein abundance increases in response to DNA replication stress	re-entry into mitotic cell cycle after pheromone arrest	molecular_function	cellular_component
YKL097C_d	YKL097C	YKL097C	hom	Dubious	0.865784402944677	0.193304202000827	no	1010	0.174981109078118	567	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related <i>Saccharomyces</i> species	Unknown	Unknown	Unknown
YMR316W	YMR316W	DIA1	hom	Verified	0.865153329297873	0.193477318686999	no	1011	0.211535847200249	722	NA					Protein of unknown function, involved in invasive and pseudohyphal growth; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern	pseudohyphal growth|invasive growth in response to glucose limitation	molecular_function	cytoplasm
YLR016C	YLR016C	PML1	hom	Verified	0.864630157352235	0.193620907360487	no	1012	0.147884684844109	521	NA	FT	RNA PROCESSING|RNA LOCALIZATION	NUCLEUS		Subunit of the RES complex, which is required for nuclear retention of unspliced pre-mRNAs; acts in the same pathway as Pml39p and Mlp1p	mRNA export from nucleus|mRNA splicing, via spliceosome|maintenance of RNA location	molecular_function	RES complex|nucleus|cytoplasm
YCL033C	YCL033C	MXR2	hom	Verified	0.863733443671167	0.193867168614631	no	1013	0.182485183274005	629	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|RESPONSE TO OXIDATIVE STRESS	MITOCHONDRION		Methionine-R-sulfoxide reductase, involved in the response to oxidative stress; protects iron-sulfur clusters from oxidative inactivation along with MXR1; involved in the regulation of lifespan	cellular response to oxidative stress	peptide-methionine (R)-S-oxide reductase activity	mitochondrion
YER061C	YER061C	CEM1	hom	Verified	0.863624661205887	0.193897056130704	no	1014	0.216269255499469	767	NA	FT	KETONE METABOLISM|LIPID METABOLISM	MITOCHONDRION		Mitochondrial beta-keto-acyl synthase with possible role in fatty acid synthesis; required for mitochondrial respiration	fatty acid biosynthetic process	fatty acid synthase activity	mitochondrion
YPR071W_p	YPR071W	YPR071W	hom	Uncharacterized	0.86354746800323	0.193918266335538	no	1015	0.203895082756648	702	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Putative membrane protein; YPR071W is not an essential gene; YPR071W has paralog YIL029C	biological_process	molecular_function	integral to membrane
YDR148C	YDR148C	KGD2	hom	Verified	0.862734271175677	0.194141792519179	no	1016	0.195067588740039	665	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Dihydrolipoyl transsuccinylase, component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes the oxidative decarboxylation of alpha-ketoglutarate to succinyl-CoA in the TCA cycle; phosphorylated	tricarboxylic acid cycle|mitochondrial genome maintenance|2-oxoglutarate metabolic process	dihydrolipoyllysine-residue succinyltransferase activity	mitochondrial nucleoid|mitochondrion|mitochondrial oxoglutarate dehydrogenase complex
YNL032W	YNL032W	SIW14	hom	Verified	0.861379914119774	0.19451441744573	no	1017	0.189548816201529	680	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION			Tyrosine phosphatase that plays a role in actin filament organization and endocytosis; localized to the cytoplasm	actin filament organization|endocytosis|protein dephosphorylation|response to stress	protein tyrosine phosphatase activity	cytoplasm
YIR018W	YIR018W	YAP5	hom	Verified	0.860567243194855	0.194738216813146	no	1018	0.18118221678957	646	NA	FT	TRANSCRIPTION FROM RNA POL II|GENE SILENCING	NUCLEUS|CHROMOSOME		Basic leucine zipper (bZIP) iron-sensing transcription factor; YAP5 has a paralog, YAP7, that arose from the whole genome duplication	negative regulation of chromatin silencing at telomere|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter in response to iron|positive regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding RNA polymerase II transcription factor activity	nuclear chromatin|nucleus
YML075C	YML075C	HMG1	hom	Verified	0.859174460264469	0.195122135830359	no	1019	0.194165675886545	666	NA	FT	LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM		HMG-CoA reductase; catalyzes the conversion of HMG-CoA to mevalonate, which is a rate-limiting step in sterol biosynthesis; one of two isozymes; localizes to the nuclear envelope; overproduction induces the formation of karmellae; forms foci at the nuclear periphery upon DNA replication stress	ergosterol biosynthetic process|isopentenyl diphosphate biosynthetic process, mevalonate pathway	hydroxymethylglutaryl-CoA reductase (NADPH) activity	nuclear envelope|integral to membrane|endoplasmic reticulum membrane
YDL154W	YDL154W	MSH5	hom	Verified	0.859087109184601	0.195146229376584	no	1020	0.177769976100121	625	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME		Protein of the MutS family, forms a dimer with Msh4p that facilitates crossovers between homologs during meiosis; msh5-Y823H mutation confers tolerance to DNA alkylating agents; homologs present in C. elegans and humans	reciprocal meiotic recombination	molecular_function	nucleus
YJL064W_d	YJL064W	YJL064W	hom	Dubious	0.856737576782905	0.195794965614673	no	1021	0.188187105891989	665	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene YJL065C/DLS1	Unknown	Unknown	Unknown
YJL124C	YJL124C	LSM1	hom	Verified	0.856684737877898	0.195809570151469	no	1022	0.226894669847578	779	NA	FF|FT	RNA PROCESSING	NUCLEUS		Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) involved in degradation of cytoplasmic mRNAs; unlike most Sm-like proteins, Lsm1p requires both its SM-domain and C-terminal domain for RNA-binding; forms cytoplasmic foci upon DNA replication stress	deadenylation-dependent decapping of nuclear-transcribed mRNA|nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	RNA binding|RNA cap binding	mRNA cap binding complex|cytoplasmic mRNA processing body|cytoplasm
YER120W	YER120W	SCS2	hom	Verified	0.855691078302055	0.196084338193387	no	1023	0.191426654612996	689	NA	FT	PROTEIN LOCALIZATION|LIPID METABOLISM|GENE SILENCING	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|SITE OF POLARIZED GROWTH		Integral ER membrane protein, regulates phospholipid metabolism; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PI4P levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; interacts with FFAT motif of Opi1p; involved in telomeric silencing; null shows inositol auxotrophy above 34 deg C; VAP homolog; SCS2 has a paralog, SCS22, that arose from the whole genome duplication	endoplasmic reticulum inheritance|regulation of intracellular lipid transport|negative regulation of transcription factor import into nucleus|phospholipid biosynthetic process|chromatin silencing at telomere	phosphatidylinositol binding|FFAT motif binding	nuclear membrane|integral to endoplasmic reticulum membrane|nuclear envelope|endoplasmic reticulum|cellular bud tip
YBR072W	YBR072W	HSP26	hom	Verified	0.855389855030255	0.196167679014397	no	1024	0.185732945085653	634	NA	FT		NUCLEUS		Small heat shock protein (sHSP) with chaperone activity; forms hollow, sphere-shaped oligomers that suppress unfolded proteins aggregation; oligomer activation requires heat-induced conformational change; also has mRNA binding activity	protein folding|response to stress	unfolded protein binding|mRNA binding	nucleus|cytoplasm
YPL077C_p	YPL077C	YPL077C	hom	Uncharacterized	0.854982761547682	0.19628034555636	no	1025	0.199988293814138	684	NA					Putative protein of unknown function; regulates PIS1 expression; mutant displays spore wall assembly defect in ether sensitivity screen; YPL077C is not an essential gene; YPL077C has a paralog, YBR197C, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YMR187C_p	YMR187C	YMR187C	hom	Uncharacterized	0.854921313240567	0.196297355298726	no	1026	0.193079730295657	643	NA					Putative protein of unknown function; YMR187C is not an essential gene	biological_process	molecular_function	integral to membrane
YIL007C	YIL007C	NAS2	hom	Verified	0.854559905313979	0.196397416100772	no	1027	0.168318030640729	596	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS	NUCLEUS		Proteasome-interacting protein; involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); similar to mammalian proteasomal modulator subunit; non-essential gene; interacts with Rpn4p; protein abundance increases in response to DNA replication stress	proteasome regulatory particle assembly|ubiquitin-dependent protein catabolic process	molecular_function	cytosol|nucleus|cytoplasm
YGL136C	YGL136C	MRM2	hom	Verified	0.853179529892016	0.196779876640572	no	1028	0.165567565253338	553	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	MITOCHONDRION		Mitochondrial 2' O-ribose methyltransferase, required for methylation of U(2791) in 21S rRNA; MRM2 deletion confers thermosensitive respiration and loss of mitochondrial DNA; has similarity to Spb1p and Trm7p, and to E. coli FtsJ/RrmJ	rRNA methylation	rRNA (uridine-2'-O-)-methyltransferase activity	mitochondrion
YKL197C	YKL197C	PEX1	hom	Verified	0.853132501024254	0.196792914866441	no	1029	0.192029389475776	660	NA	FT	PROTEIN LOCALIZATION|SIGNALING|PEROXISOME ORGANIZATION			AAA-peroxin that heterodimerizes with AAA-peroxin Pex6p and participates in the recycling of peroxisomal signal receptor Pex5p from the peroxisomal membrane to the cystosol; induced by oleic acid and upregulated during anaerobiosis	protein import into peroxisome matrix, receptor recycling	ATPase activity|protein heterodimerization activity	peroxisomal membrane|peroxisome
YJL187C	YJL187C	SWE1	hom	Verified	0.849872129345607	0.197698091163721	no	1030	0.180212149932372	660	NA	FT	CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION	NUCLEUS|SITE OF POLARIZED GROWTH		Protein kinase that regulates the G2/M transition by inhibition of Cdc28p kinase activity; localizes to the nucleus and to the daughter side of the mother-bud neck; homolog of S. pombe Wee1p; potential Cdc28p substrate	negative regulation of spindle pole body separation|G2/M transition size control checkpoint|protein phosphorylation|re-entry into mitotic cell cycle|G2/M transition of mitotic cell cycle|cell shape checkpoint|regulation of cyclin-dependent protein kinase activity|regulation of cell size|regulation of meiosis	protein tyrosine kinase activity|protein kinase activity	nucleus|cellular bud neck
YHR158C	YHR158C	KEL1	hom	Verified	0.849177727655531	0.19789120228021	no	1031	0.190769074720613	648	NA	FT	CELL CYCLE|MEMBRANE ORGANIZATION	SITE OF POLARIZED GROWTH		Protein required for proper cell fusion and cell morphology; functions in a complex with Kel2p to negatively regulate mitotic exit, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential Cdc28p substrate	negative regulation of exit from mitosis|regulation of cell shape|cell morphogenesis|cytogamy|plasma membrane fusion	molecular_function	mating projection tip|cellular bud neck|cytoplasm|cellular bud tip
YGR239C	YGR239C	PEX21	hom	Verified	0.845694223417614	0.198861673249494	no	1032	0.214629452957206	707	NA	FT	PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION			Peroxin required for peroxisomal matrix protein targeting; acts on proteins containing the PTS2 targeting sequence; interacts with Pex7p; partially redundant with Pex18p; relative distribution to cytoplasmic foci increases upon DNA replication stress	protein import into peroxisome matrix|positive regulation of protein binding	protein binding	cytosol|peroxisome
YGR248W	YGR248W	SOL4	hom	Verified	0.844374377635446	0.1992301177675	no	1033	0.187420441585312	614	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		6-phosphogluconolactonase; protein abundance increases in response to DNA replication stress; SOL4 has a paralog, SOL3, that arose from the whole genome duplication	pentose-phosphate shunt, oxidative branch	6-phosphogluconolactonase activity	cytosol|nucleus|cytoplasm
YPL013C	YPL013C	MRPS16	hom	Verified	0.843428751659003	0.199494348748274	no	1034	0.220137171925851	734	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the small subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YGR269W_d	YGR269W	YGR269W	hom	Dubious	0.843234144068882	0.199548753019913	no	1035	0.210741174461885	724	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF HUA1/YGR268C	Unknown	Unknown	Unknown
YLR152C_p	YLR152C	YLR152C	hom	Uncharacterized	0.84280249082613	0.199669457362992	no	1036	0.19419611797278	679	NA					Putative protein of unknown function; YLR152C is not an essential gene	biological_process	molecular_function	integral to membrane
YJL129C	YJL129C	TRK1	hom	Verified	0.840817148180328	0.200225189454655	no	1037	0.246791782848189	847	NA	FF|FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Component of the Trk1p-Trk2p potassium transport system; 180 kDa high affinity potassium transporter; phosphorylated in vivo and interacts physically with the phosphatase Ppz1p, suggesting Trk1p acitivy is regulated by phosphorylation; TRK1 has a paralog, TRK2, that arose from the whole genome duplication	cellular potassium ion homeostasis	potassium ion transmembrane transporter activity	membrane raft|integral to membrane|plasma membrane
YAL015C	YAL015C	NTG1	hom	Verified	0.840601667190512	0.200285562214272	no	1038	0.183452550817245	603	NA	FT	RESPONSE TO DNA DAMAGE|MITOCHONDRION ORGANIZATION|RESPONSE TO OXIDATIVE STRESS	NUCLEUS|MITOCHONDRION		DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; NTG1 has a paralog, NTG2, that arose from the whole genome duplication	DNA repair|cellular response to oxidative stress|base-excision repair|base-excision repair, AP site formation|positive regulation of mitochondrial DNA replication	oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity|oxidized purine nucleobase lesion DNA N-glycosylase activity|DNA-(apurinic or apyrimidinic site) lyase activity	mitochondrion|nucleus
YOR010C	YOR010C	TIR2	hom	Verified	0.838289002769116	0.200934205373487	no	1039	0.171855539980725	543	NA					Putative cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; transcription is induced by cold shock and anaerobiosis	response to stress	molecular_function	fungal-type cell wall
YHR047C	YHR047C	AAP1	hom	Verified	0.836575511735221	0.201415607597963	no	1040	0.181849670374261	611	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|PROTEOLYSIS|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS		Arginine/alanine amino peptidase; overproduction stimulates glycogen accumulation; AAP1 has a paralog, APE2, that arose from the whole genome duplication	glycogen metabolic process|proteolysis	aminopeptidase activity	nucleus|cytoplasm
YJL165C	YJL165C	HAL5	hom	Verified	0.836300644103656	0.201492895449149	no	1041	0.180950400105342	584	NA	FT	PROTEIN LOCALIZATION|ION HOMEOSTASIS|PROTEIN PHOSPHORYLATION|ION HOMEOSTASIS			Putative protein kinase; overexpression increases sodium and lithium tolerance, whereas gene disruption increases cation and low pH sensitivity and impairs potassium uptake, suggesting a role in regulation of Trk1p and/or Trk2p transporters; HAL5 has a paralog, KKQ8, that arose from the whole genome duplication	cellular cation homeostasis|protein phosphorylation|cellular protein localization|protein dephosphorylation	protein kinase activity	cellular_component
YGL198W	YGL198W	YIP4	hom	Verified	0.835483237259336	0.201722840583585	no	1042	0.215775096903247	709	NA	FT		ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Protein that interacts with Rab GTPases, localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport	biological_process	Rab GTPase binding	integral to membrane|Golgi apparatus
YPR004C	YPR004C	AIM45	hom	Verified	0.835050418424115	0.201844660684479	no	1043	0.199793898117391	694	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Putative ortholog of mammalian electron transfer flavoprotein complex subunit ETF-alpha; interacts with frataxin, Yfh1p; null mutant displays elevated frequency of mitochondrial genome loss; may have a role in oxidative stress response	biological_process	molecular_function	mitochondrion
YJR129C_p	YJR129C	YJR129C	hom	Uncharacterized	0.831854453736317	0.202745551539965	no	1044	0.186268130274703	653	NA					Putative protein of unknown function; predicted S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	biological_process	S-adenosylmethionine-dependent methyltransferase activity	cytoplasm
YJL078C	YJL078C	PRY3	hom	Verified	0.83105181989918	0.202972177955564	no	1045	0.165304679568598	598	NA					Cell wall-associated protein involved in export of acetylated sterols; member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis related 1 proteins); role in mating efficiency; expression of full-length transcript is daughter cell-specific; in response to alpha factor, a short transcript starting at +452 is expressed and the long form is repressed by Ste12p	biological_process	molecular_function	fungal-type cell wall
YDL129W	YDL129W	YDL129W	hom	Verified	0.831007596153657	0.202984669077575	no	1046	0.161120366904758	520	NA	FT		NUCLEUS		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; YDL129W is not an essential gene; relative distribution to the nucleus increases upon DNA replication stress	biological_process	molecular_function	nucleus|cytoplasm
YIR016W_p	YIR016W	YIR016W	hom	Uncharacterized	0.830875140998945	0.203022084157163	no	1047	0.178963582697897	660	NA					Putative protein of unknown function; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p; overexpression causes a cell cycle delay or arrest; non-essential gene; YIR016W has a paralog, YOL036W, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YLR246W	YLR246W	ERF2	hom	Verified	0.830283353072041	0.20318929889782	no	1048	0.177852828213413	598	NA	FT	PROTEIN LOCALIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Subunit of a palmitoyltransferase, composed of Erf2p and Shr5p, that adds a palmitoyl lipid moiety to heterolipidated substrates such as Ras1p and Ras2p through a thioester linkage; mutants partially mislocalize Ras2p to the vacuole	protein targeting to membrane|protein palmitoylation	palmitoyltransferase activity	endoplasmic reticulum palmitoyltransferase complex|integral to endoplasmic reticulum membrane|integral to membrane
YHR184W	YHR184W	SSP1	hom	Verified	0.8302315411508	0.203203942712133	no	1049	0.20313571460693	741	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL WALL ORG/BIOGENESIS|CELL DIVISION			Protein involved in the control of meiotic nuclear division and coordination of meiosis with spore formation; transcription is induced midway through meiosis	ascospore wall assembly|protein complex assembly	molecular_function	prospore membrane
YOL114C_p	YOL114C	YOL114C	hom	Uncharacterized	0.82859659961421	0.203666356394687	no	1050	0.212929767247397	711	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION			Putative protein of unknown function with similarity to human ICT1 and prokaryotic factors that may function in translation termination; YOL114C is not an essential gene	biological_process	molecular_function	cellular_component
YGL082W_p	YGL082W	YGL082W	hom	Uncharacterized	0.828095066960327	0.203808331506235	no	1051	0.170339631070009	593	NA	FT		NUCLEUS		Putative protein of unknown function; predicted prenylation/proteolysis target of Afc1p and Rce1p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YGL082W is not an essential gene	biological_process	molecular_function	nucleus|plasma membrane|cytoplasm
YDL199C_p	YDL199C	YDL199C	hom	Uncharacterized	0.827658655603247	0.203931919906752	no	1052	0.179610339269305	616	NA					Putative transporter, member of the sugar porter family	transport|transmembrane transport	substrate-specific transmembrane transporter activity	integral to membrane|membrane
YER098W	YER098W	UBP9	hom	Verified	0.827506627468914	0.203974983612581	no	1053	0.219483620198245	762	NA	FT	PROTEOLYSIS			Ubiquitin-specific protease that cleaves ubiquitin-protein fusions; UBP9 has a paralog, UBP13, that arose from the whole genome duplication	protein deubiquitination	ubiquitin-specific protease activity	cytoplasm
YHR203C	YHR203C	RPS4B	hom	Verified	0.825332694733465	0.204591367401191	no	1054	0.234533173674482	778	NA	FT	TRANSLATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S4, no bacterial homolog; RPS4B has a paralog, RPS4A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic small ribosomal subunit|90S preribosome
YNL089C_d	YNL089C	YNL089C	hom	Dubious	0.825240519616937	0.204617526646654	no	1055	0.205655948138814	707	NA					Dubious open reading frame unlikely to encode a functional protein; almost completely overlaps YNL090W/RHO2 which encodes a small GTPase of the Rho/Rac subfamily of Ras-like proteins	Unknown	Unknown	Unknown
YDR322C-A	YDR322C-A	TIM11	hom	Verified	0.824931356737628	0.204705281425299	no	1056	0.191095453395	663	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS	MITOCHONDRION		Subunit e of mitochondrial F1F0-ATPase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; essential for the dimeric and oligomeric state of ATP synthase	protein oligomerization|cristae formation|ATP synthesis coupled proton transport	structural molecule activity|proton-transporting ATPase activity, rotational mechanism	mitochondrion|integral to membrane|mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
YJR035W	YJR035W	RAD26	hom	Verified	0.82466594098207	0.204780636596044	no	1057	0.177349219323375	611	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		Protein involved in transcription-coupled nucleotide excision repair of UV-induced DNA lesions; recruitment to DNA lesions is dependent on an elongating RNA polymerase II; homolog of human CSB protein	transcription-coupled nucleotide-excision repair|nucleotide-excision repair	DNA-dependent ATPase activity	nucleus|cytoplasm
YOR093C_p	YOR093C	YOR093C	hom	Uncharacterized	0.82429503078005	0.204885970718799	no	1058	0.159532764877983	518	NA	FT		NUCLEUS		Putative protein of unknown function; deletion causes sensitivity to unfolded protein response-inducing agents	biological_process	molecular_function	integral to membrane
YOL155C	YOL155C	HPF1	hom	Verified	0.822661452147032	0.205350271042198	no	1059	0.213939623562974	768	NA	FT	CELL WALL ORG/BIOGENESIS			Haze-protective mannoprotein that reduces the particle size of aggregated proteins in white wines	fungal-type cell wall organization	glucosidase activity	fungal-type cell wall|extracellular region
YHL042W_p	YHL042W	YHL042W	hom	Uncharacterized	0.822412155632899	0.205421181723617	no	1060	0.185671330537483	606	NA					Putative protein of unknown function; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins	biological_process	molecular_function	cellular_component
YBR278W	YBR278W	DPB3	hom	Verified	0.822082960697788	0.205514841238587	no	1061	0.213051483815152	717	NA	FT	RESPONSE TO DNA DAMAGE|GENE SILENCING	NUCLEUS|CHROMOSOME		Third-largest subunit of DNA polymerase II (DNA polymerase epsilon); required to maintain fidelity of chromosomal replication and also for inheritance of telomeric silencing; stabilizes the interaction of Pol epsilon with primer-template DNA, positively affecting the processivity of the polymerase and exonuclease activities of Pol epsilon; mRNA abundance peaks at the G1/S boundary of the cell cycle; DPB3 has a paralog, DLS1, that arose from the whole genome duplication	DNA-dependent DNA replication|chromatin silencing at telomere	double-stranded DNA binding|single-stranded DNA binding|DNA-directed DNA polymerase activity	epsilon DNA polymerase complex
YNL183C	YNL183C	NPR1	hom	Verified	0.821209427985602	0.205763493604601	no	1062	0.190068932585284	671	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|PROTEIN PHOSPHORYLATION	GOLGI APPARATUS|PLASMA MEMBRANE		Protein kinase that stabilizes several plasma membrane amino acid transporters by antagonizing their ubiquitin-mediated degradation; phosphorylates Aly2p; negatively regulates Ldb19p-mediated endocytosis through phosphorylation of Ldb19p, which prevents its association with the plasma membrane; Npr1p activity is negatively regulated via phosphorylation by the TOR complex	regulation of transmembrane transporter activity|regulation of nitrogen utilization|protein phosphorylation|negative regulation of endocytosis	protein serine/threonine kinase activity	Golgi apparatus|plasma membrane|cytoplasm
YMR098C	YMR098C	ATP25	hom	Verified	0.819074587251219	0.206371929935267	no	1063	0.228456035584134	803	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial protein required for the stability of Oli1p (Atp9p) mRNA and for the Oli1p ring formation; YMR098C is not an essential gene	mRNA stabilization|mitochondrial proton-transporting ATP synthase complex assembly	molecular_function	mitochondrion|mitochondrial inner membrane
YNR027W	YNR027W	BUD17	hom	Verified	0.819068871010376	0.206373560511732	no	1064	0.218477315288895	729	NA	FT	CELL CYCLE|CELL DIVISION|COFACTOR METABOLISM	NUCLEUS		Putative pyridoxal kinase, a key enzyme in vitamin B6 metabolism; involved in bud-site selection; diploid mutants display a random rather than a bipolar budding pattern; similarity to yeast BUD16 and human pyridoxal kinase (PDXK)	pyridoxal phosphate biosynthetic process|cellular bud site selection	pyridoxal kinase activity	nucleus|cytoplasm
YBR051W_d	YBR051W	YBR051W	hom	Dubious	0.819051121155065	0.206378623764887	no	1065	0.202945215321273	685	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partiallly overlaps the REG2/YBR050C regulatory subunit of the Glc7p type-1 protein phosphatase	Unknown	Unknown	Unknown
YJR008W	YJR008W	MHO1	hom	Verified	0.81888685247817	0.206425485887399	no	1066	0.198511617096803	658	NA	FT		NUCLEUS		Protein of unknown function; inhibits haploid invasive growth when overexpressed; synthetically lethal with phospholipase C (PLC1); expression induced by mild heat-stress on a non-fermentable carbon source, upon entry into stationary phase and upon nitrogen deprivation; repressed by inosine and choline in an Opi1p-dependent manner; highly conserved from bacteria to human; Memo, the human homolog, is an ErbB2 interacting protein with an essential function in cell motility	biological_process	molecular_function	nucleus|cytoplasm
YOR197W	YOR197W	MCA1	hom	Verified	0.817800759650903	0.206735482115889	no	1067	0.187966897075972	639	NA	FT	PROTEOLYSIS	NUCLEUS		Ca2+-dependent cysteine protease; may cleave specific substrates during the stress response; regulates apoptosis upon H2O2 treatment; required for clearance of insoluble protein aggregates during normal growth; implicated in cell cycle dynamics; undergoes autocatalytic processing; similar to mammalian metacaspases, but exists as a monomer due to an extra pair of anti-parallel beta-strands that form a continuous beta-sheet, blocking potential dimerization	misfolded or incompletely synthesized protein catabolic process|apoptotic process	cysteine-type peptidase activity	nucleus
YBR214W	YBR214W	SDS24	hom	Verified	0.816968060687594	0.206973340389788	no	1068	0.206108917090774	683	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CELL DIVISION			Protein involved in cell separation during budding; one of two S. cerevisiae homologs (Sds23p and Sds24p) of the S. pombe Sds23 protein, which is implicated in APC/cyclosome regulation; may play an indirect role in fluid-phase endocytosis; protein abundance increases in response to DNA replication stress; SDS24 has a paralog, SDS23, that arose from the whole genome duplication	endocytosis|cytokinetic cell separation	molecular_function	cytoplasm
YOL128C	YOL128C	YGK3	hom	Verified	0.816911433498606	0.206989521676483	no	1069	0.204390082347744	665	NA	FT	PROTEOLYSIS|PROTEIN PHOSPHORYLATION			Protein kinase related to mammalian glycogen synthase kinases of the GSK-3 family; GSK-3 homologs (Mck1p, Rim11p, Mrk1p, Ygk3p) are involved in control of Msn2p-dependent transcription of stress responsive genes and in protein degradation	proteolysis|protein phosphorylation|response to stress	protein serine/threonine kinase activity|protein kinase activity	cellular_component
YOL082W	YOL082W	ATG19	hom	Verified	0.815552527771875	0.207378055085173	no	1070	0.178007058742329	561	NA	FT	PROTEIN LOCALIZATION|PROTEOLYSIS|VACUOLAR TRANSPORT			Receptor protein for the cytoplasm-to-vacuole targeting (Cvt) pathway; delivers cargo proteins aminopeptidase I (Ape1p) and alpha-mannosidase (Ams1p) to the phagophore assembly site for packaging into Cvt vesicles	vesicle organization|ER-associated protein catabolic process|protein processing|protein complex localization|CVT pathway	protein binding, bridging	pre-autophagosomal structure|cytoplasm|CVT complex|extrinsic to membrane
YML047W-A_d	YML047W-A	YML047W-A	hom	Dubious	0.815188644199839	0.207482168499583	no	1071	0.202884998164646	655	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YNL335W_p	YNL335W	DDI3	hom	Uncharacterized	0.812790428330946	0.208169112142519	no	1072	0.208841595422533	722	NA					Protein of unknown function; expression is induced over 100-fold by DNA damage; induction decreased in rad6 and rad18 mutants	biological_process	molecular_function	cellular_component
YDL110C	YDL110C	TMA17	hom	Verified	0.810071289431908	0.20894960209768	no	1073	0.190190446811554	646	NA	FT		NUCLEUS		Protein of unknown function that associates with ribosomes; heterozygous deletion demonstrated increases in chromosome instability in a rad9 deletion background; protein abundance is decreased upon intracellular iron depletion	biological_process	molecular_function	ribosome|nucleus|cytoplasm
YDL215C	YDL215C	GDH2	hom	Verified	0.809165278872906	0.209210041843524	no	1074	0.193332908948797	590	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS	MITOCHONDRION		NAD(+)-dependent glutamate dehydrogenase, degrades glutamate to ammonia and alpha-ketoglutarate; expression sensitive to nitrogen catabolite repression and intracellular ammonia levels	nitrogen compound metabolic process	glutamate dehydrogenase (NAD+) activity	mitochondrion
YAL067C	YAL067C	SEO1	hom	Verified	0.808821940286341	0.209308787086284	no	1075	0.195513848997214	638	NA					Putative permease, member of the allantoate transporter subfamily of the major facilitator superfamily; mutation confers resistance to ethionine sulfoxide	transport	transporter activity	integral to membrane|membrane
YKL121W_p	YKL121W	DGR2	hom	Uncharacterized	0.808010018725272	0.209542407350606	no	1076	0.211673668789161	714	NA					Protein of unknown function; null mutant is resistant to 2-deoxy-D-glucose and displays abnormally elongated buds	biological_process	molecular_function	cellular_component
YJL171C	YJL171C	YJL171C	hom	Verified	0.80661218148412	0.209944976678663	no	1077	0.176121841560013	567	NA	FT		MITOCHONDRION|PLASMA MEMBRANE		GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	mitochondrion|fungal-type cell wall|plasma membrane
YNL249C	YNL249C	MPA43	hom	Verified	0.806319806424067	0.210029236505053	no	1078	0.220014870568005	753	NA	FT	CARBOHYDRATE METABOLISM	MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YGL141W	YGL141W	HUL5	hom	Verified	0.805829545845897	0.210170569717817	no	1079	0.219835856844192	734	NA	FT	PROTEOLYSIS	NUCLEUS		Multiubiquitin chain assembly factor (E4); proteasome processivity factor that elongates polyUb chains on substrates, opposing Ubp6p, a branched polyubiquitin protease; required for retrograde transport of misfolded proteins during ERAD	ER-associated protein catabolic process|protein polyubiquitination	ubiquitin-ubiquitin ligase activity	proteasome complex|nucleus|cytoplasm
YHR037W	YHR037W	PUT2	hom	Verified	0.804979722017972	0.210415690777774	no	1080	0.228414636963219	788	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS	MITOCHONDRION		Delta-1-pyrroline-5-carboxylate dehydrogenase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; deficiency of the human homolog causes HPII, an autosomal recessive inborn error of metabolism	glutamate biosynthetic process|proline catabolic process to glutamate	1-pyrroline-5-carboxylate dehydrogenase activity	mitochondrion|mitochondrial matrix
YJR149W_p	YJR149W	YJR149W	hom	Uncharacterized	0.804933657274342	0.210428982370478	no	1081	0.174195905215535	561	NA	FT	OXIDATION-REDUCTION PROCESS			Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	biological_process	molecular_function	cytoplasm
YBL019W	YBL019W	APN2	hom	Verified	0.803164564243591	0.210939812044997	no	1082	0.181693813749962	560	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		Class II abasic (AP) endonuclease involved in repair of DNA damage; homolog of human HAP1 and E. coli exoIII	base-excision repair	DNA-(apurinic or apyrimidinic site) lyase activity|double-stranded DNA specific 3'-5' exodeoxyribonuclease activity|phosphoric diester hydrolase activity	nucleus
YLR400W_d	YLR400W	YLR400W	hom	Dubious	0.802803823794975	0.211044065851975	no	1083	0.208711739365387	677	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YNL099C	YNL099C	OCA1	hom	Verified	0.802023721877903	0.211269618160842	no	1084	0.22816699793793	793	NA	FF|FT	RESPONSE TO OXIDATIVE STRESS			Putative protein tyrosine phosphatase, required for cell cycle arrest in response to oxidative damage of DNA	cellular response to oxidative stress	protein tyrosine phosphatase activity	cytoplasm
YOR038C	YOR038C	HIR2	hom	Verified	0.801547002455669	0.211407522421962	no	1085	0.202958856317017	662	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION	NUCLEUS		Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; recruits Swi-Snf complexes to histone gene promoters; promotes heterochromatic gene silencing with Asf1p	DNA replication-independent nucleosome assembly|regulation of transcription from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter	nucleosome binding|transcription corepressor activity|DNA binding	HIR complex|nucleus
YPR146C_d	YPR146C	YPR146C	hom	Dubious	0.800362291806134	0.211750460917778	no	1086	0.194067830500054	713	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YOL095C	YOL095C	HMI1	hom	Verified	0.799861711720171	0.211895461745847	no	1087	0.230273769945991	767	NA	FT	RESPONSE TO DNA DAMAGE|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial inner membrane localized ATP-dependent DNA helicase, required for the maintenance of the mitochondrial genome; not required for mitochondrial transcription; has homology to E. coli helicase uvrD	mitochondrial genome maintenance|mitochondrial DNA metabolic process	ATP-dependent 3'-5' DNA helicase activity	mitochondrion|mitochondrial matrix
YOR303W	YOR303W	CPA1	hom	Verified	0.798949858313533	0.212159743527467	no	1088	0.191730742686494	592	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Small subunit of carbamoyl phosphate synthetase, which catalyzes a step in the synthesis of citrulline, an arginine precursor; translationally regulated by an attenuator peptide encoded by YOR302W within the CPA1 mRNA 5'-leader	arginine biosynthetic process	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity	carbamoyl-phosphate synthase complex
YOR211C	YOR211C	MGM1	hom	Verified	0.798604577859674	0.212259866177969	no	1089	0.203435846585957	686	NA	FT	MEMBRANE ORGANIZATION|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial GTPase, present in complex with Ugo1p and Fzo1p; required for mt morphology and genome maintenance; exists as long and short form with different distributions; homolog of human OPA1 involved in autosomal dominant optic atrophy	mitochondrion organization|mitochondrial genome maintenance|mitochondrial fusion	GTPase activity	intrinsic to mitochondrial inner membrane|extrinsic to mitochondrial inner membrane|mitochondrion|mitochondrial inner boundary membrane|mitochondrial crista|mitochondrial intermembrane space
YDR507C	YDR507C	GIN4	hom	Verified	0.798500812266243	0.212289960987293	no	1090	0.221327017910454	796	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION	SITE OF POLARIZED GROWTH		Protein kinase involved in bud growth and assembly of the septin ring; proposed to have kinase-dependent and kinase-independent activities; undergoes autophosphorylation; similar to Hsl1p; GIN4 has a paralog, KCC4, that arose from the whole genome duplication	protein autophosphorylation|budding cell bud growth|protein phosphorylation|septin checkpoint|septin ring assembly	protein kinase activity	cellular bud neck
YNL092W_p	YNL092W	YNL092W	hom	Uncharacterized	0.797974239808361	0.212442719577351	no	1091	0.192920982453081	635	NA					Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; YNL092W is not an essential gene	biological_process	S-adenosylmethionine-dependent methyltransferase activity	cellular_component
YLR410W	YLR410W	VIP1	hom	Verified	0.796113683107066	0.212982980870991	no	1092	0.190821403856469	662	NA	FT		CYTOSKELETON		Inositol hexakisphosphate (IP6) and inositol heptakisphosphate (IP7) kinase; IP7 production is important for phosphate signaling; involved in cortical actin cytoskeleton function, and invasive pseudohyphal growth analogous to S. pombe asp1	inositol phosphate biosynthetic process	inositol hexakisphosphate 1-kinase activity|inositol hexakisphosphate 3-kinase activity|inositol heptakisphosphate kinase activity|inositol hexakisphosphate 4-kinase activity|inositol hexakisphosphate 6-kinase activity	cytoplasm
YBR053C_p	YBR053C	YBR053C	hom	Uncharacterized	0.796106025820905	0.212985206019481	no	1093	0.189691904605934	628	NA					Putative protein of unknown function; induced by cell wall perturbation	biological_process	molecular_function	cellular_component
YJL136C	YJL136C	RPS21B	hom	Verified	0.793795771908036	0.213657167242897	no	1094	0.222277420954095	745	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21B has a paralog, RPS21A, that arose from the whole genome duplication	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|cytoplasmic translation|endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome	cytosolic small ribosomal subunit
YPR089W_p	YPR089W	YPR089W	hom	Uncharacterized	0.793351570296213	0.213786509289338	no	1095	0.219489593118364	780	NA	FT		GOLGI APPARATUS		Protein of unknown function; exhibits genetic interaction with ERG11 and protein-protein interaction with Hsp82p	biological_process	molecular_function	cellular_component
YCR021C	YCR021C	HSP30	hom	Verified	0.791753742737524	0.21425213950028	no	1096	0.190446039858184	599	NA	FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS	PLASMA MEMBRANE		Hydrophobic plasma membrane localized, stress-responsive protein that negatively regulates the H(+)-ATPase Pma1p; induced by heat shock, ethanol treatment, weak organic acid, glucose limitation, and entry into stationary phase	negative regulation of ATPase activity|response to stress	molecular_function	integral to membrane|plasma membrane
YNL070W	YNL070W	TOM7	hom	Verified	0.788597627138043	0.215173609125401	no	1097	0.236261656305354	823	NA	FF|FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex	protein import into mitochondrial matrix|protein import into mitochondrial outer membrane	protein channel activity	mitochondrial outer membrane|mitochondrion|integral to membrane|mitochondrial outer membrane translocase complex
YCR051W_p	YCR051W	YCR051W	hom	Uncharacterized	0.78836955297573	0.215240287396515	no	1098	0.211324454150109	742	NA	FT		NUCLEUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; contains ankyrin (Ank) repeats; YCR051W is not an essential gene	biological_process	molecular_function	nucleus|cytoplasm
YJL119C_d	YJL119C	YJL119C	hom	Dubious	0.787606383341911	0.21546348986054	no	1099	0.191576763004009	631	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YOR342C	YOR342C	YOR342C	hom	Verified	0.78717498031281	0.215589720685665	no	1100	0.226512939024011	786	NA	FT		NUCLEUS		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; relocalizes from nucleus to cytoplasm upon DNA replication stress; YOR342C has a paralog, YAL037W, that arose from the whole genome duplication	biological_process	molecular_function	nucleus|cytoplasm
YNL094W	YNL094W	APP1	hom	Verified	0.786403471459241	0.215815575180076	no	1101	0.237893035979767	837	NA	FT	CYTOSKELETON ORGANIZATION	CYTOSKELETON		Phosphatidate phosphatase, converts phosphatidate to diacylglycerol; App1p, Pah1p, Dpp1p, and Lpp1p are responsible for all the phosphatidate phosphatase activity; component of cortical actin patches; interacts with components of endocytic pathway	actin cytoskeleton organization	molecular_function	actin cytoskeleton|actin cortical patch
YJR038C_d	YJR038C	YJR038C	hom	Dubious	0.784467733753674	0.216382853836228	no	1102	0.206688420057596	701	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YKR100C	YKR100C	SKG1	hom	Verified	0.784445821515748	0.216389280274999	no	1103	0.225925836162589	782	NA	FT	CELL WALL ORG/BIOGENESIS	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Transmembrane protein with a role in cell wall polymer composition; localizes on the inner surface of the plasma membrane at the bud and in the daughter cell	fungal-type cell wall organization	molecular_function	incipient cellular bud site|cellular bud|cellular bud tip
YDR169C-A_p	YDR169C-A	YDR169C-A	hom	Uncharacterized	0.783576249550376	0.216644398202614	no	1104	0.233508725333483	779	NA					Putative protein of unknown function; identified by fungal homology and RT-PCR	biological_process	molecular_function	cellular_component
YDL072C	YDL072C	YET3	hom	Verified	0.782839016530269	0.216860826299408	no	1105	0.213307044787946	732	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein of unknown function; YET3 null mutant decreases the level of secreted invertase; homolog of human BAP31 protein; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	integral to membrane|endoplasmic reticulum
YLR177W_p	YLR177W	YLR177W	hom	Uncharacterized	0.78194430909547	0.217123651683584	no	1106	0.213890801088697	711	NA					Putative protein of unknown function; phosphorylated by Dbf2p-Mob1p in vitro; some strains contain microsatellite polymophisms at this locus; not an essential gene; YLR177W has a paralog, PSP1, that arose from the whole genome duplication	biological_process	molecular_function	cytoplasm
YBL082C	YBL082C	ALG3	hom	Verified	0.780592044488677	0.217521236150781	no	1107	0.19904717373776	674	NA	FT	LIPID METABOLISM|CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Dolichol-P-Man dependent alpha(1-3) mannosyltransferase, involved in the synthesis of dolichol-linked oligosaccharide donor for N-linked glycosylation of proteins	oligosaccharide-lipid intermediate biosynthetic process|protein glycosylation	alpha-1,3-mannosyltransferase activity	integral to membrane|endoplasmic reticulum
YHL032C	YHL032C	GUT1	hom	Verified	0.780579785215045	0.21752484246754	no	1108	0.20731870313688	707	NA	FT	CARBOHYDRATE METABOLISM	MITOCHONDRION		Glycerol kinase, converts glycerol to glycerol-3-phosphate; glucose repression of expression is mediated by Adr1p and Ino2p-Ino4p; derepression of expression on non-fermentable carbon sources is mediated by Opi1p and Rsf1p	glycerol metabolic process	glycerol kinase activity	mitochondrion|cytoplasm
YIR033W	YIR033W	MGA2	hom	Verified	0.780491367593921	0.21755085334612	no	1109	0.176460562742848	565	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|LIPID METABOLISM|GENE SILENCING	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM		ER membrane protein involved in regulation of OLE1 transcription, acts with homolog Spt23p; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting	positive regulation of transcription from RNA polymerase II promoter in response to hypoxia|cellular response to cold|positive regulation of unsaturated fatty acid biosynthetic process by positive regulation of transcription from RNA polymerase II promoter|mRNA stabilization|positive regulation of transcription from RNA polymerase II promoter in response to cobalt ion|positive regulation of transcription from RNA polymerase II promoter|chromatin silencing at silent mating-type cassette	molecular_function	integral to endoplasmic reticulum membrane|nucleus
YIL160C	YIL160C	POT1	hom	Verified	0.779366723902433	0.217881859952406	no	1110	0.205809386721837	691	NA	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS			3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids	fatty acid beta-oxidation	mRNA binding|acetyl-CoA C-acyltransferase activity	peroxisomal matrix|peroxisome
YNR031C	YNR031C	SSK2	hom	Verified	0.779121735137921	0.217954003873759	no	1111	0.216243090006448	751	NA	FT	SIGNALING|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION	SITE OF POLARIZED GROWTH		MAP kinase kinase kinase of the HOG1 mitogen-activated signaling pathway; interacts with Ssk1p, leading to autophosphorylation and activation of Ssk2p which phosphorylates Pbs2p; also mediates actin cytoskeleton recovery from osmotic stress	MAPK cascade involved in osmosensory signaling pathway|protein autophosphorylation|protein phosphorylation|response to osmotic stress|actin cytoskeleton organization|osmosensory signaling pathway via two-component system	MAP kinase kinase kinase activity	cytosol|cellular bud neck|cellular bud tip
YOR079C	YOR079C	ATX2	hom	Verified	0.778981949047015	0.217995174041586	no	1112	0.17759222264266	591	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Golgi membrane protein involved in manganese homeostasis; overproduction suppresses the sod1 (copper, zinc superoxide dismutase) null mutation	cellular manganese ion homeostasis	manganese ion transmembrane transporter activity	integral to membrane|Golgi membrane
YOL121C	YOL121C	RPS19A	hom	Verified	0.778412995221506	0.218162790077897	no	1113	0.221894610182692	730	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; required for assembly and maturation of pre-40 S particles; homologous to mammalian ribosomal protein S19, no bacterial homolog; mutations in human RPS19 are associated with Diamond Blackfan anemia; RPS19A has a paralog, RPS19B, that arose from the whole genome duplication	cytoplasmic translation|ribosomal small subunit biogenesis|rRNA export from nucleus	structural constituent of ribosome	cytosolic small ribosomal subunit
YLR012C_p	YLR012C	YLR012C	hom	Uncharacterized	0.777997714878622	0.218285180179045	no	1114	0.253900373495764	883	NA					Putative protein of unknown function; YLR012C is not an essential gene	biological_process	molecular_function	cellular_component
YBL008W-A_p	YBL008W-A	YBL008W-A	hom	Uncharacterized	0.776670401390325	0.218676626957507	no	1115	0.211602875753512	752	NA					Putative protein of unknown function; identified by fungal homology and RT-PCR	biological_process	molecular_function	cellular_component
YIL113W	YIL113W	SDP1	hom	Verified	0.776274045890195	0.218793597068819	no	1116	0.236819596549778	798	NA	FT	SIGNALING|CELL WALL ORG/BIOGENESIS|PROTEIN PHOSPHORYLATION	NUCLEUS		Stress-inducible dual-specificity MAP kinase phosphatase, negatively regulates Slt2p MAP kinase by direct dephosphorylation, diffuse localization under normal conditions shifts to punctate localization after heat shock	inactivation of MAPK activity involved in cell wall biogenesis|MAPK cascade involved in cell wall biogenesis	MAP kinase tyrosine phosphatase activity	nucleus|cytoplasm
YOR376W_d	YOR376W	YOR376W	hom	Dubious	0.772917199908096	0.21978569240311	no	1117	0.200744904053538	649	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YOR376W is not an essential gene.	Unknown	Unknown	Unknown
YMR165C	YMR165C	PAH1	hom	Verified	0.772444178046576	0.21992569841248	no	1118	0.224852486554211	773	NA	FT	LIPID METABOLISM|MEMBRANE ORGANIZATION|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM		Mg2+-dependent phosphatidate (PA) phosphatase; dephosphorylates PA to yield diacylglycerol; responsible for de novo lipid synthesis and formation of lipid droplets; phosphorylation by Pho80p-Pho85p decreases catalytic activity and alters Pah1p localization and abundance; phosphorylation by protein kinase A decreases catalytic efficiency; dephosphorylation by Nem1p-Spo7p anchors Pah1p to the membrane increasing substrate catalysis; homologous to mammalian lipins 1 and 2	plasmid maintenance|vacuole fusion, non-autophagic|lipid particle organization|aerobic respiration|phospholipid biosynthetic process	phosphatidate phosphatase activity	cytosol|nuclear membrane|vacuole|cytoplasm|extrinsic to membrane
YBR137W	YBR137W	YBR137W	hom	Verified	0.771181057522849	0.220299810190987	no	1119	0.194130691368104	696	NA					Protein of unknown function; localized to the cytoplasm; binds to Replication Protein A (RPA); also interacts with Sgt2p; YBR137W is not an essential gene	biological_process	molecular_function	TRC complex|cytoplasm
YLR099C	YLR099C	ICT1	hom	Verified	0.770475504622803	0.220508939986373	no	1120	0.224333051160295	807	NA	FT	KETONE METABOLISM|LIPID METABOLISM			Lysophosphatidic acid acyltransferase; responsible for enhanced phospholipid synthesis during organic solvent stress; null displays increased sensitivity to Calcofluor white; highly expressed during organic solvent stress; ICT1 has a paralog, ECM18, that arose from the whole genome duplication	phosphatidic acid biosynthetic process	lysophosphatidic acid acyltransferase activity	cellular_component
YPL191C_p	YPL191C	YPL191C	hom	Uncharacterized	0.770429259910156	0.220522651147286	no	1121	0.213867714209548	734	NA					Putative protein of unknown function; diploid deletion strain exhibits high budding index; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	biological_process	molecular_function	cytoplasm
YGL010W_p	YGL010W	YGL010W	hom	Uncharacterized	0.769243320383711	0.22087443891983	no	1122	0.220482638108973	731	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Putative protein of unknown function; YGL010W is not an essential gene	biological_process	molecular_function	integral to membrane|endoplasmic reticulum
YJL083W	YJL083W	TAX4	hom	Verified	0.767583594204759	0.221367306094132	no	1123	0.18988062309941	632	NA	FT	LIPID METABOLISM|SIGNALING|CELL WALL ORG/BIOGENESIS|RESPONSE TO NUTRIENT LEVELS			EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; TAX4 has a paralog, IRS4, that arose from the whole genome duplication	autophagy|fungal-type cell wall organization|inositol lipid-mediated signaling|CVT pathway|cellular response to starvation	molecular_function	pre-autophagosomal structure
YIR028W	YIR028W	DAL4	hom	Verified	0.76688565923291	0.221574750401851	no	1124	0.215398527964705	715	NA					Allantoin permease; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation	allantoin catabolic process|allantoin transport	allantoin uptake transmembrane transporter activity	integral to membrane|membrane
YGR230W	YGR230W	BNS1	hom	Verified	0.766168932680907	0.221787895639479	no	1125	0.211922248847365	757	NA	FT	CELL CYCLE			Protein with some similarity to Spo12p; overexpression bypasses need for Spo12p, but not required for meiosis	meiosis	molecular_function	cellular_component
YGR022C_d	YGR022C	YGR022C	hom	Dubious	0.765516804257215	0.221981931952343	no	1126	0.186079220405719	640	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W	Unknown	Unknown	Unknown
YOL017W	YOL017W	ESC8	hom	Verified	0.764967843206063	0.222145346637117	no	1127	0.228029446137789	784	NA	FT	GENE SILENCING	NUCLEUS		Protein involved in telomeric and mating-type locus silencing; interacts with Sir2p and also interacts with Gal11p, which is a component of the RNA pol II mediator complex; ESC8 has a paralog, IOC3, that arose from the whole genome duplication	chromatin silencing	molecular_function	nucleus
YMR097C	YMR097C	MTG1	hom	Verified	0.764538711655877	0.222273138285623	no	1128	0.240882448779585	834	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Putative GTPase peripheral to the mitochondrial inner membrane, essential for respiratory competence, likely functions in assembly of the large ribosomal subunit, has homologs in plants and animals	mitochondrial translation	GTPase activity	mitochondrion|mitochondrial inner membrane
YGR051C_d	YGR051C	YGR051C	hom	Dubious	0.764511668659305	0.222281192859782	no	1129	0.20920859985617	723	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YGR051C is not an essential gene	Unknown	Unknown	Unknown
YEL011W	YEL011W	GLC3	hom	Verified	0.763557798119559	0.222565403278207	no	1130	0.198611021967057	681	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY			Glycogen branching enzyme, involved in glycogen accumulation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress	glycogen biosynthetic process	1,4-alpha-glucan branching enzyme activity	cytoplasm
YGR132C	YGR132C	PHB1	hom	Verified	0.76127305342177	0.223246996003484	no	1131	0.201113410944065	657	NA	FT	MEMBRANE ORGANIZATION|PROTEOLYSIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation	mitochondrion inheritance|protein folding|negative regulation of proteolysis|replicative cell aging|mitochondrion morphogenesis|inner mitochondrial membrane organization	molecular_function	mitochondrion|mitochondrial inner membrane
YOR267C	YOR267C	HRK1	hom	Verified	0.76060421762186	0.223446749930547	no	1132	0.182114628981662	592	NA	FT	ION HOMEOSTASIS|PROTEIN PHOSPHORYLATION|ION HOMEOSTASIS			Protein kinase; implicated in activation of the plasma membrane H(+)-ATPase Pma1p in response to glucose metabolism; plays a role in ion homeostasis; protein abundance increases in response to DNA replication stress	protein phosphorylation|cellular ion homeostasis	protein serine/threonine kinase activity|protein kinase activity	cytoplasm
YMR147W_p	YMR147W	YMR147W	hom	Uncharacterized	0.758176296737333	0.224172724618031	no	1133	0.19656440566197	646	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YHR006W	YHR006W	STP2	hom	Verified	0.758048418642971	0.224210998652512	no	1134	0.199100879341893	683	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS|PLASMA MEMBRANE		Transcription factor; activated by proteolytic processing in response to signals from the SPS sensor system for external amino acids; activates transcription of amino acid permease genes; STP2 has a paralog, STP1, that arose from the whole genome duplication	positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus|cytoplasm
YDR241W_d	YDR241W	BUD26	hom	Dubious	0.757271798057586	0.224443521609574	no	1135	0.235480848720375	815	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 1% of ORF overlaps the verified gene SNU56; diploid mutant displays a weak budding pattern phenotype in a systematic assay	Unknown	Unknown	Unknown
YNL270C	YNL270C	ALP1	hom	Verified	0.757073511646148	0.224502911187749	no	1136	0.213103610629629	732	NA	FT		PLASMA MEMBRANE		Arginine transporter; expression is normally very low and it is unclear what conditions would induce significant expression; ALP1 has a paralog, CAN1, that arose from the whole genome duplication	basic amino acid transport	basic amino acid transmembrane transporter activity	integral to membrane|plasma membrane
YGR121W-A_p	YGR121W-A	YGR121W-A	hom	Uncharacterized	0.756840838616169	0.224572611412795	no	1137	0.218431920722138	743	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YBR286W	YBR286W	APE3	hom	Verified	0.75640959406943	0.224701828770192	no	1138	0.232689403831491	808	NA	FT	PROTEOLYSIS			Vacuolar aminopeptidase Y, processed to mature form by Prb1p	vacuolar protein catabolic process	aminopeptidase activity	fungal-type vacuole
YEL004W	YEL004W	YEA4	hom	Verified	0.75612847658844	0.224786085016131	no	1139	0.18480952162965	595	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter required for cell wall chitin synthesis; localized to the ER	fungal-type cell wall chitin biosynthetic process|UDP-N-acetylglucosamine transport|UDP-glucose transport|transmembrane transport	UDP-N-acetylglucosamine transmembrane transporter activity	integral to membrane|endoplasmic reticulum
YDL190C	YDL190C	UFD2	hom	Verified	0.755995318498393	0.224826001275319	no	1140	0.23321294808444	824	NA	FT	PROTEOLYSIS	NUCLEUS		Ubiquitin chain assembly factor (E4) that cooperates with a ubiquitin-activating enzyme (E1), a ubiquitin-conjugating enzyme (E2), and a ubiquitin protein ligase (E3) to conjugate ubiquitin to substrates; also functions as an E3	ER-associated protein catabolic process|protein ubiquitination|ubiquitin-dependent protein catabolic process|response to stress	ubiquitin-ubiquitin ligase activity	nucleus|cytoplasm
YPL136W_d	YPL136W	YPL136W	hom	Dubious	0.755080609731755	0.225100308399823	no	1141	0.232854254722784	811	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene GIP3/YPL137C	Unknown	Unknown	Unknown
YDL071C_d	YDL071C	YDL071C	hom	Dubious	0.754676825722702	0.225221457331444	no	1142	0.252849771631574	891	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF BDF2/YDL070W	Unknown	Unknown	Unknown
YDR035W	YDR035W	ARO3	hom	Verified	0.75459325905601	0.225246534784551	no	1143	0.308654987320212	1082	NA	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS|MITOCHONDRION		3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase, catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by phenylalanine or high concentration of tyrosine or tryptophan	aromatic amino acid family biosynthetic process	3-deoxy-7-phosphoheptulonate synthase activity	mitochondrion|nucleus|cytoplasm
YPL070W	YPL070W	MUK1	hom	Verified	0.754241397122335	0.225352142092917	no	1144	0.213003773251887	712	NA					Cytoplasmic protein of unknown function containing a Vps9 domain; computational analysis of large-scale protein-protein interaction data suggests a possible role in transcriptional regulation	biological_process	molecular_function	cytoplasm
YDR058C	YDR058C	TGL2	hom	Verified	0.753771455464398	0.225493233389216	no	1145	0.231293450033071	794	NA	FT	PROTEIN LOCALIZATION|LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION		Triacylglycerol lipase that is localized to the mitochondria; has lipolytic activity towards triacylglycerols and diacylglycerols when expressed in E. coli	triglyceride catabolic process	triglyceride lipase activity	mitochondrion
YBR128C	YBR128C	ATG14	hom	Verified	0.753279557264806	0.225640970276315	no	1146	0.218554816651176	738	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|PROTEOLYSIS|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS|PEROXISOME ORGANIZATION			Autophagy-specific subunit of phosphatidylinositol 3-kinase complex I (with Vps34/15/30p); Atg14p targets complex I to the phagophore assembly site (PAS); required for localizing additional ATG proteins to the PAS; required for overflow degradation of misfolded proteins when ERAD is saturated; homolog of human Barkor	piecemeal microautophagy of nucleus|ER-associated protein catabolic process|peroxisome degradation|macroautophagy|CVT pathway	1-phosphatidylinositol-3-kinase activity	phosphatidylinositol 3-kinase complex I|fungal-type vacuole membrane|pre-autophagosomal structure|extrinsic to membrane
YPR037C	YPR037C	ERV2	hom	Verified	0.748729109964486	0.227010247288174	no	1147	0.219636686559363	725	NA	FT	OXIDATION-REDUCTION PROCESS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Flavin-linked sulfhydryl oxidase localized to the endoplasmic reticulum lumen, involved in disulfide bond formation within the ER	protein thiol-disulfide exchange	thiol oxidase activity	integral to endoplasmic reticulum membrane
YPL140C	YPL140C	MKK2	hom	Verified	0.748286444029444	0.227143699694278	no	1148	0.226264788364685	756	NA	FT	SIGNALING|PROTEIN PHOSPHORYLATION|PEROXISOME ORGANIZATION			MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk1p; MKK2 has a paralog, MKK1, that arose from the whole genome duplication	signal transduction|peroxisome degradation|protein phosphorylation	MAP kinase kinase activity	intracellular
YDR008C_d	YDR008C	YDR008C	hom	Dubious	0.747419661962528	0.227405140250493	no	1149	0.365782718027443	1263	NA	FF				Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YER105C	YER105C	NUP157	hom	Verified	0.747347672977812	0.227426861334689	no	1150	0.183403832671593	642	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC assembly and tethering of DNA to the nuclear periphery; both Nup170p and NUP157p are similar to human Nup155p; NUP157 has a paralog, NUP170, that arose from the whole genome duplication	nucleocytoplasmic transport|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|mitotic cell cycle spindle assembly checkpoint|nuclear pore complex assembly|transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery	structural constituent of nuclear pore	integral to membrane|nuclear pore|nuclear pore inner ring
YOR101W	YOR101W	RAS1	hom	Verified	0.746716247271172	0.227617430151748	no	1151	0.19356484336387	692	NA	FT	SIGNALING|NUCLEOTIDE METABOLISM	PLASMA MEMBRANE		GTPase involved in G-protein signaling in adenylate cyclase activation; plays a role in cell proliferation; localized to the plasma membrane; homolog of mammalian RAS proto-oncogenes; relative distribution to the nucleus increases upon DNA replication stress	adenylate cyclase-activating G-protein coupled receptor signaling pathway|replicative cell aging|Ras protein signal transduction	GTPase activity	plasma membrane
YDR102C_d	YDR102C	YDR102C	hom	Dubious	0.746073112169461	0.227811625337209	no	1152	0.210307236848156	663	NA					Dubious open reading frame; homozygous diploid deletion strain exhibits high budding index	Unknown	Unknown	Unknown
YCL061C	YCL061C	MRC1	hom	Verified	0.744552963300794	0.228271006006334	no	1153	0.25063900331882	867	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION|GENE SILENCING	NUCLEUS|CHROMOSOME		S-phase checkpoint protein required for DNA replication; interacts with and stabilizes Pol2p at stalled replication forks during stress, where it forms a pausing complex with Tof1p and is phosphorylated by Mec1p; protects uncapped telomeres	maintenance of DNA repeat elements|intra-S DNA damage checkpoint|DNA repair|DNA replication checkpoint|telomere maintenance|replication fork protection|DNA replication|mitotic sister chromatid cohesion|chromatin silencing at silent mating-type cassette|chromatin silencing at telomere	molecular_function	nuclear chromosome|replication fork protection complex|nucleus|nuclear replication fork
YIL149C	YIL149C	MLP2	hom	Verified	0.74285295080083	0.228785356666851	no	1154	0.208194050312055	690	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|CYTOSKELETON ORGANIZATION|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION|CYTOSKELETON		Myosin-like protein associated with the nuclear envelope, connects the nuclear pore complex with the nuclear interior; involved in the Tel1p pathway that controls telomere length	poly(A)+ mRNA export from nucleus|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|regulation of transcription, DNA-dependent|telomere tethering at nuclear periphery|spindle pole body organization|transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery	ribonucleoprotein complex binding	nucleoplasm|nuclear envelope|mitochondrion|ribonucleoprotein complex|integral to membrane|spindle pole body
YCL001W-A_p	YCL001W-A	YCL001W-A	hom	Uncharacterized	0.742339461847141	0.228940844178333	no	1155	0.252735781649338	897	NA					Putative protein of unknown function; YCL001W-A gene has similarity to DOM34 and is present in a region duplicated between chromosomes XIV and III	biological_process	molecular_function	cellular_component
YLR181C	YLR181C	VTA1	hom	Verified	0.74162309701246	0.229157862749328	no	1156	0.221020251056475	759	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|VACUOLAR TRANSPORT			Multivesicular body (MVB) protein involved in endosomal protein sorting; regulates Vps4p activity by promoting its oligomerization; has an N-terminal Vps60- and Did2- binding domain, a linker region, and a C-terminal Vps4p binding domain	late endosome to vacuole transport via multivesicular body sorting pathway|positive regulation of protein oligomerization|late endosome to vacuole transport	ATPase activator activity	endosome|endosome membrane|multivesicular body
YPL135W	YPL135W	ISU1	hom	Verified	0.741077714931293	0.22932316041193	no	1157	0.236648761038757	836	NA	FT	RNA PROCESSING|ION HOMEOSTASIS|ION HOMEOSTASIS|COFACTOR METABOLISM	MITOCHONDRION		Conserved protein of the mitochondrial matrix, performs a scaffolding function during assembly of iron-sulfur clusters, interacts physically and functionally with yeast frataxin (Yfh1p); isu1 isu2 double mutant is inviable	cellular iron ion homeostasis|iron-sulfur cluster assembly|tRNA wobble uridine modification	ferrous iron binding	mitochondrion|mitochondrial matrix
YMR015C	YMR015C	ERG5	hom	Verified	0.740406376299454	0.22952672548972	no	1158	0.277684655168839	990	NA	FF|FT	LIPID METABOLISM|OXIDATION-REDUCTION PROCESS	ENDOPLASMIC RETICULUM		C-22 sterol desaturase, a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis; may be a target of azole antifungal drugs	ergosterol biosynthetic process	C-22 sterol desaturase activity	endoplasmic reticulum
YBR139W	YBR139W	YBR139W	hom	Verified	0.739684158930076	0.229745831158021	no	1159	0.239080342944587	812	NA	FT	PROTEOLYSIS			Putative serine type carboxypeptidase with a role in phytochelatin synthesis; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner	phytochelatin biosynthetic process	serine hydrolase activity|serine-type carboxypeptidase activity	fungal-type vacuole
YOR198C	YOR198C	BFR1	hom	Verified	0.738924068430673	0.229976553192954	no	1160	0.263977369191411	914	NA	FT	CELL CYCLE	ENDOMEMBRANE SYSTEM		Component of mRNP complexes associated with polyribosomes; implicated in secretion and nuclear segregation; multicopy suppressor of BFA (Brefeldin A) sensitivity	meiosis|mRNA metabolic process|regulation of mitosis	RNA binding	ribonucleoprotein complex|polysome|nuclear outer membrane-endoplasmic reticulum membrane network
YBR050C	YBR050C	REG2	hom	Verified	0.738534191677724	0.230094948818009	no	1161	0.194148269855342	627	NA	FT	TRANSCRIPTION FROM RNA POL II			Regulatory subunit of the Glc7p type-1 protein phosphatase; involved with Reg1p, Glc7p, and Snf1p in regulation of glucose-repressible genes, also involved in glucose-induced proteolysis of maltose permease	negative regulation of transcription from RNA polymerase II promoter	protein phosphatase type 1 regulator activity	protein phosphatase type 1 complex
YBR197C	YBR197C	YBR197C	hom	Verified	0.738173254230267	0.2302045867075	no	1162	0.231177698184067	792	NA	FT		NUCLEUS		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YBR197C is not an essential gene; relative distribution to the nucleus increases upon DNA replication stress; YBR197C has a paralog, YPL077C, that arose from the whole genome duplication	biological_process	molecular_function	nucleus|cytoplasm
YNR034W	YNR034W	SOL1	hom	Verified	0.737403076490557	0.230438632569139	no	1163	0.182203639239945	638	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|RNA LOCALIZATION|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol3p and Sol4p; SOL1 has a paralog, SOL2, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress	tRNA export from nucleus	molecular_function|6-phosphogluconolactonase activity	nucleus|cytoplasm
YBR082C	YBR082C	UBC4	hom	Verified	0.736549619022002	0.230698141234231	no	1164	0.20740673923753	708	NA	FT	PROTEOLYSIS			Ubiquitin-conjugating enzyme (E2); mediates degradation of abnormal or excess proteins, including calmodulin and histone H3; interacts with many SCF ubiquitin protein ligases; component of the cellular stress response; UBC4 has a paralog, UBC5, that arose from the whole genome duplication	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|protein monoubiquitination|protein polyubiquitination|protein ubiquitination|response to stress	ubiquitin binding|ubiquitin-protein ligase activity	proteasome complex
YJR111C_p	YJR111C	YJR111C	hom	Uncharacterized	0.735784492499153	0.230930930055972	no	1165	0.224107995005072	794	NA	FT	OXIDATION-REDUCTION PROCESS	MITOCHONDRION		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondria	biological_process	molecular_function	mitochondrion
YOR058C	YOR058C	ASE1	hom	Verified	0.735615507731155	0.230982361143319	no	1166	0.197300633208309	692	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION	NUCLEUS|CYTOSKELETON		Mitotic spindle midzone localized protein; microtubule-associated protein (MAP) family member; required for spindle elongation and stabilization; undergoes cell cycle-regulated degradation by anaphase promoting complex; potential Cdc28p substrate; relative distribution to microtubules decreases upon DNA replication stress	cytokinesis, completion of separation|mitotic anaphase B|microtubule bundle formation|spindle pole body separation|spindle midzone assembly|mitotic spindle stabilization|mitotic spindle elongation	microtubule binding	spindle midzone|nuclear microtubule|spindle
YOR034C	YOR034C	AKR2	hom	Verified	0.73494985482853	0.231185017053084	no	1167	0.209259847141161	715	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION	GOLGI APPARATUS		Ankyrin repeat-containing protein; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; possibly involved in constitutive endocytosis of Ste3p; AKR2 has a paralog, AKR1, that arose from the whole genome duplication	endocytosis|protein palmitoylation	palmitoyltransferase activity	integral to membrane|Golgi apparatus
YER091C-A_d	YER091C-A	YER091C-A	hom	Dubious	0.734902581983854	0.231199412892219	no	1168	0.24677707636593	856	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YGL208W	YGL208W	SIP2	hom	Verified	0.734459084359345	0.231334494074132	no	1169	0.216782491257776	778	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|SIGNALING|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS	PLASMA MEMBRANE		One of three beta subunits of the Snf1 serine/threonine protein kinase complex involved in the response to glucose starvation; null mutants exhibit accelerated aging; N-myristoylprotein localized to the cytoplasm and the plasma membrane	cellular response to glucose starvation|signal transduction|protein phosphorylation|replicative cell aging|invasive growth in response to glucose limitation|regulation of protein complex assembly	AMP-activated protein kinase activity	AMP-activated protein kinase complex|plasma membrane|cytoplasm
YML121W	YML121W	GTR1	hom	Verified	0.734261283941593	0.23139475461789	no	1170	0.27399681963495	949	NA	FF|FT	PROTEIN LOCALIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS|GENE SILENCING	NUCLEUS		Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB	phosphate ion transport|transcription from RNA polymerase I promoter|transcription from RNA polymerase III promoter|chromatin silencing at telomere	GDP binding|GTP binding	fungal-type vacuole membrane|EGO complex|nucleus|late endosome membrane|cytoplasm
YGL244W	YGL244W	RTF1	hom	Verified	0.73416964770762	0.231422674862874	no	1171	0.289108738045003	1005	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION|GENE SILENCING	NUCLEUS|CHROMOSOME	RNA POL II, HOLOENZYME	Subunit of RNAPII-associated chromatin remodeling Paf1 complex; regulates gene expression by directing cotranscriptional histone modification, influences transcription and chromatin structure through several independent functional domains; directly or indirectly regulates DNA-binding properties of Spt15p and relative activities of different TATA elements; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay	mRNA 3'-end processing|snoRNA transcription from an RNA polymerase II promoter|regulation of chromatin silencing at telomere|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|regulation of histone H3-K4 methylation|regulation of transcription-coupled nucleotide-excision repair|negative regulation of transcription from RNA polymerase II promoter|recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex|global genome nucleotide-excision repair|snoRNA 3'-end processing|Unknown|transcription elongation from RNA polymerase II promoter	RNA binding|RNA polymerase II transcription factor binding transcription factor activity	nucleus|transcriptionally active chromatin|Cdc73/Paf1 complex
YML002W_p	YML002W	YML002W	hom	Uncharacterized	0.730844867353791	0.232436957321419	no	1172	0.205515749835065	673	NA					Putative protein of unknown function; expression induced by heat and by calcium shortage	biological_process	molecular_function	cellular_component
YKR065C	YKR065C	PAM17	hom	Verified	0.730832953433422	0.232440596311547	no	1173	0.20993346125525	711	NA	FT	PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Constituent of the TIM23 complex; proposed alternatively to be a component of the import motor (PAM complex) or to interact with and modulate the core TIM23 (Translocase of the Inner mitochondrial Membrane) complex; protein abundance increases in response to DNA replication stress	protein import into mitochondrial matrix	molecular_function	mitochondrion|presequence translocase-associated import motor
YDR424C	YDR424C	DYN2	hom	Verified	0.730507667709388	0.232539963887256	no	1174	0.238669942784863	811	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS	ENDOMEMBRANE SYSTEM|NUCLEUS|CYTOSKELETON		Cytoplasmic light chain dynein, microtubule motor protein; proposed to be involved in the assembly of the nuclear pore complex	microtubule-based process|actin filament-based process|nuclear pore complex assembly	molecular_function	cytoplasmic dynein complex|cytoplasmic microtubule|peroxisome|nuclear pore
YBR170C	YBR170C	NPL4	hom	Verified	0.730416985802019	0.232567669408625	no	1175	0.235035880617341	782	NA	FT	PROTEIN LOCALIZATION|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM	UBIQUITIN LIGASE COMPLEX	Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase; assists Cdc48p in the dislocation of misfolded, polyubiquitinated ERAD substrates that are subsequently delivered to the proteasome for degradation; also involved in the regulated destruction of resident ER membrane proteins, such as HMG-CoA reductase (Hmg1/2p) and cytoplasmic proteins (Fbp1p); role in mobilizing membrane bound transcription factors by regulated ubiquitin/proteasome-dependent processing (RUP)	retrograde protein transport, ER to cytosol|proteasomal ubiquitin-dependent protein catabolic process|mitochondria-associated protein catabolic process|mitotic spindle disassembly|ER-associated protein catabolic process|ER-associated misfolded protein catabolic process|Unknown|cytoplasm-associated proteasomal ubiquitin-dependent protein catabolic process	molecular_function	Doa10p ubiquitin ligase complex|integral to membrane|Cdc48p-Npl4p-Ufd1p AAA ATPase complex|Cdc48p-Npl4p-Vms1p AAA ATPase complex|nuclear outer membrane-endoplasmic reticulum membrane network
YLR073C	YLR073C	RFU1	hom	Verified	0.729897851068178	0.232726312978342	no	1176	0.253089347257113	869	NA					Protein that inhibits Doa4p deubiquitinating activity; contributes to ubiquitin homeostasis by regulating the conversion of free ubiquitin chains to ubiquitin monomers by Doa4p; GFP-fusion protein localizes to endosomes	regulation of ubiquitin homeostasis	enzyme inhibitor activity	endosome
YLR253W_p	YLR253W	YLR253W	hom	Uncharacterized	0.728014570660962	0.233302333479054	no	1177	0.235986787586254	792	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; transcription is periodic during the metabolic cycle; YLR253W is not an essential gene	biological_process	molecular_function	mitochondrion
YMR084W_p	YMR084W	YMR084W	hom	Uncharacterized	0.727210794236561	0.23354841736995	no	1178	0.236362891472792	821	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Putative protein of unknown function; YMR084W and adjacent ORF YMR085W are merged in related strains, and together are paralogous to glutamine-fructose-6-phosphate amidotransferase GFA1	biological_process	molecular_function	cellular_component
YMR293C	YMR293C	HER2	hom	Verified	0.726038995177928	0.233907432694644	no	1179	0.243341348778509	868	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION	MITOCHONDRION		Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; required for remodeling of ER caused by Hmg2p overexpression; similar to bacterial GatA glutamyl-tRNA amidotransferase	endoplasmic reticulum organization|glutaminyl-tRNAGln biosynthesis via transamidation	glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity	mitochondrion|glutamyl-tRNA(Gln) amidotransferase complex
YER141W	YER141W	COX15	hom	Verified	0.725947745645709	0.233935402516715	no	1180	0.215003928075623	745	NA	FT	OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM	MITOCHONDRION		Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase	heme a biosynthetic process	oxidoreductase activity, acting on NADH or NADPH, heme protein as acceptor	mitochondrion|integral to membrane|mitochondrial inner membrane
YAL056C-A_d	YAL056C-A	YAL056C-A	hom	Dubious	0.725355977247394	0.234116836432519	no	1181	0.253096238920629	853	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YJL137C	YJL137C	GLG2	hom	Verified	0.725264747881428	0.234144813936167	no	1182	0.218431794444756	751	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY			Glycogenin glucosyltransferase; self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; similar to mammalian glycogenin; GLG2 has a paralog, GLG1, that arose from the whole genome duplication	glycogen biosynthetic process	glycogenin glucosyltransferase activity	cytoplasm
YNL042W	YNL042W	BOP3	hom	Verified	0.724315518672202	0.234436025893247	no	1183	0.207810457365443	682	NA	FT		NUCLEUS		Protein of unknown function, potential Cdc28p substrate; overproduction confers resistance to methylmercury	cellular response to methylmercury	molecular_function	nucleus|cytoplasm
YDL113C	YDL113C	ATG20	hom	Verified	0.724285170967336	0.234445339504116	no	1184	0.21697396898833	727	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS			Sorting nexin family member required for the cytoplasm-to-vacuole targeting (Cvt) pathway and for endosomal sorting; has a Phox homology domain that binds phosphatidylinositol-3-phosphate; interacts with Snx4p; potential Cdc28p substrate	mitochondrion degradation|early endosome to Golgi transport|macroautophagy|CVT pathway	phosphatidylinositol-3-phosphate binding	endosome|pre-autophagosomal structure|extrinsic to membrane
YLR265C	YLR265C	NEJ1	hom	Verified	0.724177880308205	0.234478268295966	no	1185	0.221155021516426	706	NA	FT	RESPONSE TO DNA DAMAGE	ENDOMEMBRANE SYSTEM|NUCLEUS		Protein involved in regulation of nonhomologous end joining; interacts with DNA ligase IV components Dnl4p and Lif1p; repressed by MAT heterozygosity; regulates cellular distribution of Lif1p	double-strand break repair via nonhomologous end joining|double-strand break repair via single-strand annealing	DNA end binding	DNA ligase IV complex|nucleus
YBR258C	YBR258C	SHG1	hom	Verified	0.72181048659555	0.235205500618934	no	1186	0.221831578116092	716	NA	FT	CHROMATIN ORGANIZATION	NUCLEUS		Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres	histone H3-K4 methylation	histone methyltransferase activity (H3-K4 specific)	nucleus|Set1C/COMPASS complex
YPL019C	YPL019C	VTC3	hom	Verified	0.720500420989863	0.235608470303141	no	1187	0.207776785051735	704	NA	FT	MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT	ENDOPLASMIC RETICULUM		Subunit of the vacuolar transporter chaperone (VTC) complex involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion	polyphosphate metabolic process|vacuolar transport|microautophagy|vacuole fusion, non-autophagic	molecular_function	fungal-type vacuole membrane|integral to membrane|vacuolar transporter chaperone complex|endoplasmic reticulum
YDR521W_d	YDR521W	YDR521W	hom	Dubious	0.718477735950554	0.236231385415146	no	1188	0.210351179907694	653	NA					Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol	Unknown	Unknown	Unknown
YMR313C	YMR313C	TGL3	hom	Verified	0.718442783194268	0.236242157588024	no	1189	0.230677164982175	806	NA	FT	LIPID METABOLISM|CELL DIVISION			Bifunctional enzyme with triacylglycerol lipase and lysophosphatidylethanolamine acyltransferase activity; responsible for all the triacylglycerol lipase activity of the lipid particle; required with Tgl4p for timely bud formation	triglyceride catabolic process|cell budding|cellular lipid metabolic process	triglyceride lipase activity|lysophosphatidylethanolamine acyltransferase activity	lipid particle
YGR273C_p	YGR273C	YGR273C	hom	Uncharacterized	0.718045782135902	0.236364529269818	no	1190	0.244030329929034	832	NA					Putative protein of unknown function; expression downregulated by treatment with 8-methoxypsoralen plus UVA irradiation; YGR273C is not an essential gene	biological_process	molecular_function	cellular_component
YMR148W	YMR148W	OSW5	hom	Verified	0.71781751509732	0.236434906143134	no	1191	0.188066152584617	614	NA					Protein of unknown function that may play a role in spore wall assembly; predicted to contain an N-terminal transmembrane domain; osw5 null mutant spores exhibit increased spore wall permeability and sensitivity to beta-glucanase digestion	biological_process	molecular_function	integral to membrane
YBR269C_p	YBR269C	FMP21	hom	Uncharacterized	0.717171168960314	0.236634243284514	no	1192	0.238213874443844	828	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YDR079W	YDR079W	PET100	hom	Verified	0.717168622043469	0.236635028952241	no	1193	0.241289896727743	840	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Chaperone that specifically facilitates the assembly of cytochrome c oxidase, integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme	mitochondrial respiratory chain complex IV assembly|aerobic respiration	unfolded protein binding	mitochondrion|mitochondrial inner membrane|integral to mitochondrial inner membrane
YML109W	YML109W	ZDS2	hom	Verified	0.71676025610051	0.236761019407403	no	1194	0.201170284953453	652	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|GENE SILENCING	NUCLEUS|SITE OF POLARIZED GROWTH		Protein with a role in regulating Swe1p-dependent polarized growth; involved in maintenance of Cdc55p in the cytoplasm where it promotes mitotic entry; interacts with silencing proteins at the telomere; implicated in the mitotic exit network through regulation of Cdc14p localization; ZDS2 has a paralog, ZDS1, that arose from the whole genome duplication	positive regulation of G2/M transition of mitotic cell cycle|cell shape checkpoint|establishment of cell polarity|regulation of protein localization|chromatin silencing at rDNA|cell aging	molecular_function	nucleus|cellular bud neck|cellular bud tip|cytoplasm
YMR304C-A_d	YMR304C-A	YMR304C-A	hom	Dubious	0.71660411824468	0.236809201339395	no	1195	0.232697927575533	796	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene SCW10	Unknown	Unknown	Unknown
YIL055C_p	YIL055C	YIL055C	hom	Uncharacterized	0.715539214145395	0.237137959417271	no	1196	0.236565133632444	782	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YAL045C_d	YAL045C	YAL045C	hom	Dubious	0.71528730301795	0.237215766289297	no	1197	0.211509324512013	702	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps YAL044W-A	Unknown	Unknown	Unknown
YGL158W	YGL158W	RCK1	hom	Verified	0.714558406602811	0.237440976839205	no	1198	0.215762602760756	718	NA	FT	CELL CYCLE|PROTEIN PHOSPHORYLATION			Protein kinase involved in the response to oxidative stress; identified as suppressor of S. pombe cell cycle checkpoint mutations; RCK1 has a paralog, RCK2, that arose from the whole genome duplication	protein phosphorylation|regulation of meiosis	protein serine/threonine kinase activity|protein kinase activity	cellular_component
YFL021W	YFL021W	GAT1	hom	Verified	0.712441398200463	0.238095743913007	no	1199	0.207370114410677	703	NA	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Transcriptional activator of genes involved in nitrogen catabolite repression; contains a GATA-1-type zinc finger DNA-binding motif; activity and localization regulated by nitrogen limitation and Ure2p	nitrogen catabolite activation of transcription from RNA polymerase II promoter|nitrogen catabolite activation of transcription	sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II transcription factor binding transcription factor activity	cytosol|nucleus
YOR189W	YOR189W	IES4	hom	Verified	0.71207307336791	0.23820976364545	no	1200	0.238225723180517	817	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Component of the INO80 chromatiin remodeling complex and target of the Mec1p/Tel1p DNA damage signaling pathway; proposed to link chromatin remodeling to replication checkpoint responses	response to DNA damage stimulus	molecular_function	nucleus|Ino80 complex
YLL059C_d	YLL059C	YLL059C	hom	Dubious	0.71182143805491	0.238287677819388	no	1201	0.259612873879958	901	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YJL028W	YJL028W	YJL028W	hom	Verified	0.711800661841555	0.238294111409531	no	1202	0.196392220130569	652	NA					Protein of unknown function; may interact with ribosomes, based on co-purification experiments	biological_process	molecular_function	ribosome
YKL084W	YKL084W	HOT13	hom	Verified	0.711436627854152	0.238406854100535	no	1203	0.238237630175889	830	NA	FT	PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Zinc-binding mitochondrial intermembrane space (IMS) protein involved in a disulfide relay system for IMS import of cysteine-containing proteins; binds Mia40p and stimulates its Erv1p-dependent oxidation, probably by sequestering zinc	protein import into mitochondrial intermembrane space	zinc ion binding	mitochondrial intermembrane space
YBR115C	YBR115C	LYS2	hom	Verified	0.710400609742196	0.238727872586019	no	1204	0.222908340425767	734	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS			Alpha aminoadipate reductase, catalyzes the reduction of alpha-aminoadipate to alpha-aminoadipate 6-semialdehyde, which is the fifth step in biosynthesis of lysine; activation requires posttranslational phosphopantetheinylation by Lys5p	lysine biosynthetic process via aminoadipic acid	L-aminoadipate-semialdehyde dehydrogenase activity	cytoplasm
YLR285W	YLR285W	NNT1	hom	Verified	0.7092379173971	0.239088423553715	no	1205	0.221065277794031	751	NA	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|GENE SILENCING			S-adenosylmethionine-dependent methyltransferase; has a role in rDNA silencing and in lifespan determination	chromatin silencing at rDNA|nicotinamide metabolic process	S-adenosylmethionine-dependent methyltransferase activity|nicotinamide N-methyltransferase activity	cytoplasm
YPR195C_d	YPR195C	YPR195C	hom	Dubious	0.707346513683641	0.239675583344714	no	1206	0.227440304180632	792	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YPR167C	YPR167C	MET16	hom	Verified	0.707217393716677	0.239715695504869	no	1207	0.236024833405107	804	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS			3'-phosphoadenylsulfate reductase, reduces 3'-phosphoadenylyl sulfate to adenosine-3',5'-bisphosphate and free sulfite using reduced thioredoxin as cosubstrate, involved in sulfate assimilation and methionine metabolism	sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)|sulfur amino acid metabolic process	phosphoadenylyl-sulfate reductase (thioredoxin) activity	cytoplasm
YER179W	YER179W	DMC1	hom	Verified	0.707013605138738	0.239779011524694	no	1208	0.218378830556424	734	NA	FT	CELL CYCLE	NUCLEUS|CHROMOSOME		Meiosis-specific protein required for repair of double-strand breaks and pairing between homologous chromosomes; homolog of Rad51p and the bacterial RecA protein; binds ssDNA and dsDNA, forms helical filaments; stimulated by Rdh54p	meiosis|reciprocal meiotic recombination|meiotic joint molecule formation	double-stranded DNA binding|single-stranded DNA binding	condensed nuclear chromosome|nucleus
YOR380W	YOR380W	RDR1	hom	Verified	0.706214616740463	0.240027340933952	no	1209	0.232888815835354	773	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Transcriptional repressor involved in the control of multidrug resistance; negatively regulates expression of the PDR5 gene; member of the Gal4p family of zinc cluster proteins	response to xenobiotic stimulus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	nucleus
YNL056W	YNL056W	OCA2	hom	Verified	0.706060784292407	0.240075168886539	no	1210	0.239200985552154	791	NA					Putative protein with similarity to predicted tyrosine phosphatases Oca1p and Siw14p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YNL056W is not an essential gene	biological_process	molecular_function	cytoplasm
YFL054C_p	YFL054C	YFL054C	hom	Uncharacterized	0.705965415519268	0.240104822542367	no	1211	0.230414671373907	769	NA					Putative channel-like protein; similar to Fps1p; mediates passive diffusion of glycerol in the presence of ethanol	water transport|transmembrane transport	water channel activity|glycerol transmembrane transporter activity|transporter activity	integral to membrane
YKL131W_d	YKL131W	YKL131W	hom	Dubious	0.703541018339606	0.240859326845819	no	1212	0.20180909073566	661	NA					Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YBR301W	YBR301W	PAU24	hom	Verified	0.703519615013686	0.240865993581523	no	1213	0.232261331719623	789	NA	FT	CELL WALL ORG/BIOGENESIS			Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; member of the seripauperin multigene family encoded mainly in subtelomeric regions; expressed under anaerobic conditions, completely repressed during aerobic growth	biological_process	molecular_function	fungal-type cell wall
YEL013W	YEL013W	VAC8	hom	Verified	0.703376613948354	0.240910538314584	no	1214	0.226453444017549	769	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS			Phosphorylated and palmitoylated vacuolar membrane protein that interacts with Atg13p, required for the cytoplasm-to-vacuole targeting (Cvt) pathway; interacts with Nvj1p to form nucleus-vacuole junctions	piecemeal microautophagy of nucleus|vacuole inheritance|CVT vesicle assembly|vacuole fusion, non-autophagic|macroautophagy|nucleus-vacuole junction assembly	protein anchor	fungal-type vacuole membrane|nucleus-vacuole junction|Myo2p-Vac17p-Vac8p transport complex
YDR242W	YDR242W	AMD2	hom	Verified	0.702546743127119	0.241169130938592	no	1215	0.188588625634098	626	NA					Putative amidase	biological_process	amidase activity	cellular_component
YDL219W	YDL219W	DTD1	hom	Verified	0.702045149629568	0.241325503549257	no	1216	0.21957754664914	757	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION			D-Tyr-tRNA(Tyr) deacylase, functions in protein translation, may affect nonsense suppression via alteration of the protein synthesis machinery; ubiquitous among eukaryotes	Unknown	D-leucyl-tRNA(Leu) deacylase activity|D-tyrosyl-tRNA(Tyr) deacylase activity	cytoplasm
YKL155C	YKL155C	RSM22	hom	Verified	0.701940816522057	0.241358036489756	no	1217	0.243422369018311	845	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the small subunit; also predicted to be an S-adenosylmethionine-dependent methyltransferase	mitochondrial translation	structural constituent of ribosome|S-adenosylmethionine-dependent methyltransferase activity	mitochondrion|mitochondrial small ribosomal subunit
YDL117W	YDL117W	CYK3	hom	Verified	0.699973427772604	0.241971949582762	no	1218	0.238038570862625	801	NA	FT	CELL CYCLE|CELL DIVISION	SITE OF POLARIZED GROWTH|CYTOSKELETON		SH3-domain protein located in the bud neck and cytokinetic actin ring; relocalizes from bud neck to nucleus upon DNA replication stress; activates the chitin synthase activity of Chs2p during cytokinesis; suppressor of growth and cytokinesis defects of chs2 phospho-mutants	barrier septum assembly involved in cell cycle cytokinesis|cytokinesis	molecular_function	cellular bud neck contractile ring|cellular bud neck|cytoplasm
YFL034C-A	YFL034C-A	RPL22B	hom	Verified	0.699275911827816	0.242189808893419	no	1219	0.25265813457035	907	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L22B; homologous to mammalian ribosomal protein L22, no bacterial homolog; RPL22B has a paralog, RPL22A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YEL025C_p	YEL025C	YEL025C	hom	Uncharacterized	0.698554401235796	0.242415274430048	no	1220	0.203629828014457	667	NA	FT		NUCLEUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus	biological_process	molecular_function	nucleus|cytoplasm
YNL109W_d	YNL109W	YNL109W	hom	Dubious	0.697732444305799	0.242672267040165	no	1221	0.248231396577236	854	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YNL108C	Unknown	Unknown	Unknown
YDR459C	YDR459C	PFA5	hom	Verified	0.69730485983292	0.242806013670824	no	1222	0.218571144253177	756	NA	FT		PLASMA MEMBRANE		Palmitoyltransferase with autoacylation activity; likely functions in pathway(s) outside Ras; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain	protein palmitoylation	palmitoyltransferase activity	integral to membrane|plasma membrane
YGR012W	YGR012W	YGR012W	hom	Verified	0.696008873061654	0.243211636487772	no	1223	0.228972479944274	749	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		Putative cysteine synthase, localized to the mitochondrial outer membrane	cysteine biosynthetic process	cysteine synthase activity	mitochondrial outer membrane|mitochondrion
YHR189W	YHR189W	PTH1	hom	Verified	0.69536990047829	0.243411759281044	no	1224	0.239242222190572	809	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		One of two (see also PTH2) mitochondrially-localized peptidyl-tRNA hydrolases; dispensable for respiratory growth on rich medium, but required for respiratory growth on minimal medium	mitochondrial translation	aminoacyl-tRNA hydrolase activity	mitochondrion
YNL180C	YNL180C	RHO5	hom	Verified	0.695205656191193	0.243463214083178	no	1225	0.246244335241984	836	NA	FT	SIGNALING	NUCLEUS|PLASMA MEMBRANE		Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely involved in protein kinase C (Pkc1p)-dependent signal transduction pathway that controls cell integrity	Rho protein signal transduction	GTPase activity	endomembrane system|fungal-type vacuole membrane|plasma membrane|nucleus|cytoplasm
YJR131W	YJR131W	MNS1	hom	Verified	0.694798815180412	0.24359069540797	no	1226	0.246678064943118	795	NA	FT	CARBOHYDRATE METABOLISM|PROTEOLYSIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Alpha-1,2-mannosidase involved in ER-associated protein degradation (ERAD); catalyzes the removal of one mannose residue from a glycosylated protein, converting the modification from Man9GlcNAc to Man8GlcNAc; catalyzes the last step in glycoprotein maturation in the ER and is critical for ER protein degradation	ER-associated protein catabolic process|protein deglycosylation involved in glycoprotein catabolic process	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	endoplasmic reticulum
YLR416C_d	YLR416C	YLR416C	hom	Dubious	0.694772802730776	0.243598847487585	no	1227	0.235305635140586	822	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YPR159C-A_p	YPR159C-A	YPR159C-A	hom	Uncharacterized	0.694521284068768	0.243677678887816	no	1228	0.217736533066888	717	NA					Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching	biological_process	molecular_function	cellular_component
YIL105C	YIL105C	SLM1	hom	Verified	0.694266972270773	0.243757399719523	no	1229	0.231110230897701	767	NA	FT	VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|SIGNALING|CYTOSKELETON ORGANIZATION	MITOCHONDRION|PLASMA MEMBRANE		Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm2p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; phosphorylated by the TORC2 complex; protein abundance increases in response to DNA replication stress; SLM1 has a paralog, SLM2, that arose from the whole genome duplication	eisosome assembly|TOR signaling cascade|regulation of cell growth|actin filament bundle assembly|endosomal transport|establishment or maintenance of actin cytoskeleton polarity|actin cytoskeleton organization	phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol binding|sphingolipid binding	eisosome|mitochondrion|membrane raft|plasma membrane|cytoplasm
YBR061C	YBR061C	TRM7	hom	Verified	0.694097811555891	0.243810435463888	no	1230	0.241206747562649	841	NA	FT	RNA PROCESSING|TRANSLATION			2'-O-ribose methyltransferase; methylates the 2'-O-ribose of tRNA-Phe, tRNA-Trp, and tRNA-Leu at positions C32 and N34 of the tRNA anticodon loop; crucial biological role likely modification of tRNA-Phe; interacts with Trm732p and Rtt10p in 2'-O-methylation of C32 and N34 substrate tRNAs, respectively	cytoplasmic translation|tRNA methylation	tRNA methyltransferase activity	cytoplasm
YJL060W	YJL060W	BNA3	hom	Verified	0.69348632084137	0.244002203695033	no	1231	0.243782023092431	839	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		Kynurenine aminotransferase, catalyzes formation of kynurenic acid from kynurenine; potential Cdc28p substrate	kynurenic acid biosynthetic process	arylformamidase activity|kynurenine-oxoglutarate transaminase activity	mitochondrion|cytoplasm
YDR305C	YDR305C	HNT2	hom	Verified	0.693417343106789	0.244023840753413	no	1232	0.226036469965707	737	NA	FT		NUCLEUS|MITOCHONDRION		Dinucleoside triphosphate hydrolase; has similarity to the tumor suppressor FHIT and belongs to the histidine triad (HIT) superfamily of nucleotide-binding proteins	nucleoside catabolic process	hydrolase activity|nucleoside-triphosphatase activity	mitochondrion|nucleus|cytoplasm
YPL049C	YPL049C	DIG1	hom	Verified	0.693267239719032	0.244070929027309	no	1233	0.271363282549321	948	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		MAP kinase-responsive inhibitor of the Ste12p transcription factor, involved in the regulation of mating-specific genes and the invasive growth pathway; related regulators Dig1p and Dig2p bind to Ste12p	negative regulation of transcription from RNA polymerase II promoter by pheromones|Unknown	DNA binding|transcription factor binding	nucleus
YJL003W	YJL003W	COX16	hom	Verified	0.692694132752019	0.244250760962642	no	1234	0.228830479187052	780	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial inner membrane protein, required for assembly of cytochrome c oxidase	mitochondrial respiratory chain complex IV assembly	molecular_function	mitochondrion|mitochondrial inner membrane
YBL079W	YBL079W	NUP170	hom	Verified	0.6918914065756	0.244502763830647	no	1235	0.264757843539236	910	NA	FF|FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA LOCALIZATION|CHROMOSOME SEGREGATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC assembly and nucleocytoplasmic transport; both Nup170p and NUP157p are similar to human Nup155p; NUP170 has a paralog, NUP157, that arose from the whole genome duplication	nucleocytoplasmic transport|chromosome segregation|protein targeting to nuclear inner membrane|mitotic cell cycle spindle assembly checkpoint|nuclear pore complex assembly	structural constituent of nuclear pore	integral to membrane|nuclear pore|nuclear pore inner ring
YKL034W	YKL034W	TUL1	hom	Verified	0.691227281358964	0.244711361006743	no	1236	0.242845021741549	864	NA	FT	PROTEOLYSIS	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Subunit of the DSC ubiquitin ligase complex; golgi-localized RING-finger ubiquitin ligase (E3) involved in sorting polar transmembrane domain containing membrane proteins to multivesicular bodies for delivery to the vacuole; proposed involvement in the quality control of misfolded TMD containing proteins; ortholog of fission yeast dsc1	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|protein ubiquitination	ubiquitin-protein ligase activity	integral to membrane|Golgi apparatus
YBR083W	YBR083W	TEC1	hom	Verified	0.690259568847131	0.245015484320948	no	1237	0.209590377772181	724	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Transcription factor targeting filamentation genes and Ty1 expression; Ste12p activation of most filamentation gene promoters depends on Tec1p and Tec1p transcriptional activity is dependent on its association with Ste12p; binds to TCS elements upstream of filamentation genes, which are regulated by Tec1p/Ste12p/Dig1p complex; competes with Dig2p for binding to Ste12p/Dig1p; positive regulator of chronological life span; TEA/ATTS DNA-binding domain family member	pseudohyphal growth|chronological cell aging|positive regulation of transposition, RNA-mediated|invasive growth in response to glucose limitation|positive regulation of transcription from RNA polymerase II promoter in response to stress	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II transcription factor recruiting transcription factor activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YNL020C	YNL020C	ARK1	hom	Verified	0.688506630008371	0.245566898308475	no	1238	0.238539305757034	794	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Serine/threonine protein kinase; involved in regulation of the cortical actin cytoskeleton; involved in control of endocytosis; ARK1 has a paralog, PRK1, that arose from the whole genome duplication	regulation of endocytosis|actin filament organization|protein phosphorylation|cytokinesis|actin cortical patch assembly	protein serine/threonine kinase activity|protein kinase activity	mating projection tip|actin cortical patch
YLR241W_p	YLR241W	YLR241W	hom	Uncharacterized	0.688282609925381	0.245637415292809	no	1239	0.226982957421492	757	NA					Putative protein of unknown function, may be involved in detoxification	biological_process	molecular_function	integral to membrane
YKL222C	YKL222C	YKL222C	hom	Verified	0.68666552460527	0.246146763424694	no	1240	0.247053395567058	839	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS|CYTOSKELETON		Protein of unknown function that may interact with ribosomes, based on co-purification experiments; similar to transcriptional regulators from the zinc cluster (binuclear cluster) family; null mutant is sensitive to caffeine	biological_process	sequence-specific DNA binding	ribosome|nucleus|mitotic spindle
YOL032W	YOL032W	OPI10	hom	Verified	0.684832972831965	0.246724662973629	no	1241	0.214434366605243	741	NA	FT	LIPID METABOLISM|CARBOHYDRATE METABOLISM	NUCLEUS		Protein with a possible role in phospholipid biosynthesis; null mutant displays an inositol-excreting phenotype that is suppressed by exogenous choline; protein abundance increases in response to DNA replication stress	inositol metabolic process	molecular_function	nucleus|cytoplasm
YMR016C	YMR016C	SOK2	hom	Verified	0.684181485270528	0.246930286033927	no	1242	0.200863015505135	672	NA	FT		NUCLEUS		Nuclear protein that negatively regulates pseudohyphal differentiation; plays a regulatory role in the cyclic AMP (cAMP)-dependent protein kinase (PKA) signal transduction pathway; SOK2 has a paralog, PHD1, that arose from the whole genome duplication	pseudohyphal growth	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	nucleus
YGR289C	YGR289C	MAL11	hom	Verified	0.682657572682971	0.24741162256116	no	1243	0.265374739944852	919	NA	FT	CARBOHYDRATE METABOLISM	PLASMA MEMBRANE		Inducible high-affinity maltose transporter (alpha-glucoside transporter); encoded in the MAL1 complex locus; broad substrate specificity that includes maltotriose; required for isomaltose utilization	trehalose transport|maltose transport|disaccharide catabolic process	trehalose transmembrane transporter activity|alpha-glucoside:hydrogen symporter activity|maltose:hydrogen symporter activity	integral to membrane|plasma membrane
YBL091C	YBL091C	MAP2	hom	Verified	0.682357654733902	0.24750641238666	no	1244	0.247371173278274	844	NA	FT	PROTEOLYSIS			Methionine aminopeptidase, catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map1p	protein initiator methionine removal involved in protein maturation	metalloaminopeptidase activity	cytoplasm
YGR271W	YGR271W	SLH1	hom	Verified	0.680415460581083	0.248120717161945	no	1245	0.242841546628689	843	NA	FT	TRANSLATION		RIBOSOME	Putative RNA helicase related to Ski2p, involved in translation inhibition of non-poly(A) mRNAs; required for repressing propagation of dsRNA viruses	cytoplasmic translation|regulation of translation	RNA helicase activity	polysomal ribosome|cytoplasm
YNL155W	YNL155W	YNL155W	hom	Verified	0.678272972802228	0.248799315923759	no	1246	0.228900574645766	805	NA	FT		NUCLEUS		Protein of unknown function; contains a DHHC domain and an AN1-type zinc finger; predicted to have thiol-disulfide oxidoreductase active site; transcriptionally regulated by Rpn4p along with proteasome subunit genes; putative ortholog of human AIRAP, which stimulates proteasome activity in response to arsenic; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	nucleus|cytoplasm
YCR083W	YCR083W	TRX3	hom	Verified	0.677895662757784	0.248918925097381	no	1247	0.231765083164053	797	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|RESPONSE TO OXIDATIVE STRESS	MITOCHONDRION		Mitochondrial thioredoxin, highly conserved oxidoreductase required to maintain the redox homeostasis of the cell, forms the mitochondrial thioredoxin system with Trr2p, redox state is maintained by both Trr2p and Glr1p	cellular response to oxidative stress	disulfide oxidoreductase activity	mitochondrion
YDR107C	YDR107C	TMN2	hom	Verified	0.677188869015481	0.249143064587402	no	1248	0.207241813840247	656	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|VACUOLAR TRANSPORT			Protein with a role in cellular adhesion and filamentous growth; similar to Emp70p and Tmn3p; member of the evolutionarily conserved Transmembrane Nine family of proteins with nine membrane-spanning segments	cellular copper ion homeostasis|pseudohyphal growth|vacuolar transport|invasive growth in response to glucose limitation	molecular_function	fungal-type vacuole membrane|integral to membrane
YIL123W	YIL123W	SIM1	hom	Verified	0.676968117906568	0.24921309150361	no	1249	0.243093367457519	846	NA	FT	CELL WALL ORG/BIOGENESIS			Protein of the SUN family (Sim1p, Uth1p, Nca3p, Sun4p) that may participate in DNA replication, promoter contains SCB regulation box at -300 bp indicating that expression may be cell cycle-regulated	fungal-type cell wall organization	molecular_function	fungal-type cell wall
YCL035C	YCL035C	GRX1	hom	Verified	0.673731987519152	0.250240860750437	no	1250	0.234728311633483	797	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		Glutathione-dependent disulfide oxidoreductase; hydroperoxide and superoxide-radical responsive, heat-stable, with active site cysteine pair; protects cells from oxidative damage; GRX1 has a paralog, GRX2, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress	protein glutathionylation|cellular response to oxidative stress	disulfide oxidoreductase activity|glutathione transferase activity|glutathione peroxidase activity	nucleus|cytoplasm
YJR074W	YJR074W	MOG1	hom	Verified	0.672179990258124	0.250734558983522	no	1251	0.2510771995182	871	NA	FT	PROTEIN LOCALIZATION|RNA LOCALIZATION	NUCLEUS		Conserved nuclear protein that interacts with GTP-Gsp1p, which is a Ran homolog of the Ras GTPase family, and stimulates nucleotide release, involved in nuclear protein import, nucleotide release is inhibited by Yrb1p	protein import into nucleus	Ran GTPase binding	nucleus
YNR060W	YNR060W	FRE4	hom	Verified	0.6711343637956	0.251067468666369	no	1252	0.244217499986767	858	NA	FT	ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|GEN. OF PRECURSOR METABOLITES AND ENERGY	PLASMA MEMBRANE		Ferric reductase, reduces a specific subset of siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels	siderophore transport	ferric-chelate reductase activity	integral to membrane|plasma membrane
YKL127W	YKL127W	PGM1	hom	Verified	0.670930316020103	0.251132461266891	no	1253	0.219744102979069	738	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY			Phosphoglucomutase, minor isoform; catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism	glucose 6-phosphate metabolic process|galactose catabolic process|glucose 1-phosphate metabolic process|UDP-glucose metabolic process|trehalose biosynthetic process|glycogen biosynthetic process	phosphoglucomutase activity	cytoplasm
YNL014W	YNL014W	HEF3	hom	Verified	0.670924838188261	0.251134206169832	no	1254	0.262809489350985	903	NA	FT	TRANSLATION|NUCLEOTIDE METABOLISM		RIBOSOME	Translational elongation factor EF-3; member of the ABC superfamily; stimulates EF-1 alpha-dependent binding of aminoacyl-tRNA by the ribosome; normally expressed in zinc deficient cells; HEF3 has a paralog, YEF3, that arose from the whole genome duplication	translational elongation	ATPase activity|translation elongation factor activity	cytosolic ribosome
YBL059W_p	YBL059W	YBL059W	hom	Uncharacterized	0.670456965875043	0.251283265399638	no	1255	0.268247051378548	924	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YBL059W has a paralog, YER093C-A, that arose from the whole genome duplication	biological_process	molecular_function	mitochondrion
YGL006W	YGL006W	PMC1	hom	Verified	0.669729817813058	0.251515019986413	no	1256	0.23954259704736	828	NA	FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS			Vacuolar Ca2+ ATPase involved in depleting cytosol of Ca2+ ions; prevents growth inhibition by activation of calcineurin in the presence of elevated concentrations of calcium; similar to mammalian PMCA1a	cellular calcium ion homeostasis|calcium ion transport|transmembrane transport	calcium-transporting ATPase activity	fungal-type vacuole membrane|integral to membrane
YNL097C	YNL097C	PHO23	hom	Verified	0.668867284670754	0.251790070494992	no	1257	0.23705933731902	843	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS|CHROMOSOME		Probable component of the Rpd3 histone deacetylase complex, involved in transcriptional regulation of PHO5; affects termination of snoRNAs and cryptic unstable transcripts (CUTs); C-terminus has similarity to human candidate tumor suppressor p33(ING1) and its isoform ING3	positive regulation of transcription from RNA polymerase II promoter in response to heat stress|negative regulation of chromatin silencing at silent mating-type cassette|negative regulation of transcription from RNA polymerase I promoter|negative regulation of chromatin silencing at telomere|negative regulation of chromatin silencing at rDNA|chromatin modification|positive regulation of transcription from RNA polymerase II promoter	methylated histone residue binding	histone deacetylase complex|Rpd3L-Expanded complex|nucleus|Rpd3L complex
YLR236C_d	YLR236C	YLR236C	hom	Dubious	0.668721909573904	0.251836444341004	no	1258	0.237742669690787	799	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YBR201W	YBR201W	DER1	hom	Verified	0.666387393436004	0.25258175912777	no	1259	0.25611081448869	879	NA	FT	PROTEIN LOCALIZATION|PROTEOLYSIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	UBIQUITIN LIGASE COMPLEX	Endoplasmic reticulum membrane protein, required for ER-associated protein degradation of misfolded or unassembled proteins; N- and C- termini protrude into the cytoplasm, has similarity to Dfm1p	ER-associated protein catabolic process	molecular_function	integral to membrane|Hrd1p ubiquitin ligase ERAD-L complex|endoplasmic reticulum membrane
YCR050C_p	YCR050C	YCR050C	hom	Uncharacterized	0.666238629989882	0.252629292516556	no	1260	0.218201993988883	746	NA					Non-essential protein of unknown function; deletion mutant is synthetically sick or lethal with alpha-synuclein	biological_process	molecular_function	cellular_component
YIL120W	YIL120W	QDR1	hom	Verified	0.665260402784509	0.252941976234764	no	1261	0.236408862297926	806	NA	FT		PLASMA MEMBRANE		Multidrug transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; required for resistance to quinidine, ketoconazole, fluconazole, and barban; QDR1 has a paralog, AQR1, that arose from the whole genome duplication	drug transmembrane transport	drug transmembrane transporter activity	integral to membrane|plasma membrane
YDL099W	YDL099W	BUG1	hom	Verified	0.664292791704957	0.253251466832296	no	1262	0.220224403540816	766	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	GOLGI APPARATUS		Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes	protein secretion|ER to Golgi vesicle-mediated transport	molecular_function	cis-Golgi network|cytoplasm
YOL116W	YOL116W	MSN1	hom	Verified	0.664091708544135	0.253315808301157	no	1263	0.257046353625417	875	NA	FT	TRANSCRIPTION FROM RNA POL II|CARBOHYDRATE METABOLISM	NUCLEUS		Transcriptional activator; involved in regulation of invertase and glucoamylase expression, invasive growth and pseudohyphal differentiation, iron uptake, chromium accumulation, and response to osmotic stress; localizes to the nucleus; relative distribution to the nucleus increases upon DNA replication stress	positive regulation of transcription from RNA polymerase II promoter in response to heat stress|positive regulation of transcription from RNA polymerase II promoter in response to methylglyoxal|positive regulation of transcription from RNA polymerase II promoter in response to increased salt|Unknown|positive regulation of starch catabolic process by positive regulation of transcription from RNA polymerase II promoter|positive regulation of invasive growth in response to glucose limitation by positive regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding	nucleus
YMR053C	YMR053C	STB2	hom	Verified	0.662915982665264	0.253692182464204	no	1264	0.241386551239037	847	NA	FT		NUCLEUS|CHROMOSOME		Protein that interacts with Sin3p in a two-hybrid assay and is part of a large protein complex with Sin3p and Stb1p	biological_process	molecular_function	Sin3-type complex
YDR524W-C_p	YDR524W-C	YDR524W-C	hom	Uncharacterized	0.662266767617524	0.253900135404599	no	1265	0.268004942664071	923	NA					Putative protein of unknown function; small ORF identified by SAGE; deletion strains are moderately sensitive to the radiomimetic drug bleomycin	biological_process	molecular_function	cellular_component
YNR006W	YNR006W	VPS27	hom	Verified	0.660951712788604	0.254321640418041	no	1266	0.29217643659564	993	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT			Endosomal protein that forms a complex with Hse1p; required for recycling Golgi proteins, forming lumenal membranes and sorting ubiquitinated proteins destined for degradation; has Ubiquitin Interaction Motifs which bind ubiquitin (Ubi4p)	protein retention in Golgi apparatus|late endosome to vacuole transport|protein targeting to vacuole	ubiquitin binding|phosphatidylinositol-3-phosphate binding	endosome|ESCRT-0 complex
YPL183W-A	YPL183W-A	RTC6	hom	Verified	0.660531608848862	0.254456370562465	no	1267	0.260419331893335	911	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Protein involved in translation; mutants have defects in biogenesis of nuclear ribosomes; sequence similar to prokaryotic ribosomal protein L36, may be a mitochondrial ribosomal protein; protein abundance increases in response to DNA replication stress	mitochondrial translation|ribosome biogenesis	structural constituent of ribosome	mitochondrial large ribosomal subunit
YCR098C	YCR098C	GIT1	hom	Verified	0.660156518126144	0.254576696264102	no	1268	0.261160818700685	937	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Plasma membrane permease, mediates uptake of glycerophosphoinositol and glycerophosphocholine as sources of the nutrients inositol and phosphate; expression and transport rate are regulated by phosphate and inositol availability	transmembrane transport|glycerophosphodiester transport	glycerophosphodiester transmembrane transporter activity	integral to membrane|plasma membrane
YDR015C_d	YDR015C	YDR015C	hom	Dubious	0.660040416534551	0.25461394664129	no	1269	0.241626000295998	807	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene HED1/YDR014W-A	Unknown	Unknown	Unknown
YKL105C	YKL105C	SEG2	hom	Verified	0.659470441331941	0.254796860569004	no	1270	0.239028048089152	813	NA					Eisosome component and paralog of Seg1p; likely plays only minor role in eisosome assembly; shown to interact with Seg1p; similar to A. gossypii SEG gene which is important for stabilizing eisosomes	biological_process	molecular_function	cellular_component
YGL157W	YGL157W	ARI1	hom	Verified	0.658519310233647	0.255102246470744	no	1271	0.244088391231558	832	NA	FT	OXIDATION-REDUCTION PROCESS	NUCLEUS		NADPH-dependent aldehyde reductase, utilizes aromatic and alophatic aldehyde substrates; member of the short-chain dehydrogenase/reductase superfamily	biological_process	oxidoreductase activity|carbonyl reductase (NADPH) activity	nucleus|cytoplasm
YNL052W	YNL052W	COX5A	hom	Verified	0.655833124942945	0.25596575032758	no	1272	0.237536140468605	806	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Subunit Va of cytochrome c oxidase; cytochrome c oxidase is the terminal member of the mitochondrial inner membrane electron transport chain; Cox5Ap is predominantly expressed during aerobic growth while its isoform Vb (Cox5Bp) is expressed during anaerobic growth; COX5A has a paralog, COX5B, that arose from the whole genome duplication	mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity	mitochondrion|integral to membrane|mitochondrial respiratory chain complex IV
YDL216C	YDL216C	RRI1	hom	Verified	0.652522412966359	0.257032109489385	no	1273	0.261819661453651	930	NA	FT	SIGNALING|PROTEOLYSIS	NUCLEUS		Catalytic subunit of the COP9 signalosome (CSN) complex that acts as an isopeptidase in cleaving the ubiquitin-like protein Nedd8 from SCF ubiquitin ligases; metalloendopeptidase involved in the adaptation to pheromone signaling	adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion|cullin deneddylation	metalloendopeptidase activity	signalosome
YLR335W	YLR335W	NUP2	hom	Verified	0.652388003765818	0.257075450592529	no	1274	0.267586274959884	942	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RNA LOCALIZATION|GENE SILENCING	ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION|CHROMOSOME	NUCLEAR PORE	Nucleoporin involved in nucleocytoplasmic transport, binds to either the nucleoplasmic or cytoplasmic faces of the nuclear pore complex depending on Ran-GTP levels; also has a role in chromatin organization	rRNA export from nucleus|snRNA export from nucleus|nuclear pore organization|tRNA export from nucleus|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|mRNA-binding (hnRNP) protein import into nucleus|ribosomal protein import into nucleus|snRNP protein import into nucleus|chromatin silencing at telomere|chromatin silencing at silent mating-type cassette|protein targeting to membrane|poly(A)+ mRNA export from nucleus|protein export from nucleus|mRNA export from nucleus in response to heat stress|transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery|NLS-bearing substrate import into nucleus|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, non-stop decay	nucleocytoplasmic transporter activity	nuclear chromatin|mitochondrion|integral to membrane|nuclear pore
YBR012C_d	YBR012C	YBR012C	hom	Dubious	0.651560090771747	0.257342500200947	no	1275	0.256203394643605	853	NA					Dubious open reading frame, unlikely to encode a functional protein; expression induced by iron-regulated transcriptional activator Aft2p	Unknown	Unknown	Unknown
YLR408C_p	YLR408C	BLS1	hom	Uncharacterized	0.651511239638501	0.257358262007107	no	1276	0.236092547037793	776	NA					Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to the endosome; YLR408C is not an essential gene	biological_process	molecular_function	endosome|BLOC-1 complex
YDR428C	YDR428C	BNA7	hom	Verified	0.651305511001179	0.257424645806117	no	1277	0.237767756815174	790	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM			Formylkynurenine formamidase, involved in the de novo biosynthesis of NAD from tryptophan via kynurenine	NAD biosynthetic process	arylformamidase activity	cellular_component
YDL090C	YDL090C	RAM1	hom	Verified	0.651100762578269	0.257490722144996	no	1278	0.315529011241667	1091	NA	FF|FT	PROTEIN PRENYLATION			Beta subunit of the CAAX farnesyltransferase (FTase) that prenylates the a-factor mating pheromone and Ras proteins; required for the membrane localization of Ras proteins and a-factor; homolog of the mammalian FTase beta subunit	protein farnesylation	protein farnesyltransferase activity	protein farnesyltransferase complex
YDR133C_d	YDR133C	YDR133C	hom	Dubious	0.651064176495445	0.257502530120497	no	1279	0.236274495760244	805	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR134C	Unknown	Unknown	Unknown
YGR032W	YGR032W	GSC2	hom	Verified	0.650207173507369	0.257779203994838	no	1280	0.237957678258348	822	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	PLASMA MEMBRANE|CYTOSKELETON		Catalytic subunit of 1,3-beta-glucan synthase, involved in formation of the inner layer of the spore wall; activity positively regulated by Rho1p and negatively by Smk1p; has similarity to an alternate catalytic subunit, Fks1p (Gsc1p)	ascospore wall assembly|(1->3)-beta-D-glucan biosynthetic process	1,3-beta-D-glucan synthase activity	1,3-beta-D-glucan synthase complex|integral to membrane|actin cap|prospore membrane
YGR041W	YGR041W	BUD9	hom	Verified	0.648876716689373	0.258209032665666	no	1281	0.230536072934768	805	NA	FT	CELL CYCLE|CELL DIVISION	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Protein involved in bud-site selection; mutant has increased aneuploidy tolerance; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the distal pole	cellular bud site selection	molecular_function	plasma membrane|cellular bud neck
YLR254C	YLR254C	NDL1	hom	Verified	0.647685991420193	0.258594033286135	no	1282	0.251918551185881	851	NA	FT	CELL CYCLE|CELL DIVISION	NUCLEUS|CYTOSKELETON		Homolog of nuclear distribution factor NudE, NUDEL; interacts with Pac1p and regulates dynein targeting to microtubule plus ends	nuclear migration along microtubule	microtubule plus-end binding	cytoplasmic microtubule|nucleus|cytoplasm
YGL235W_p	YGL235W	YGL235W	hom	Uncharacterized	0.64758144764408	0.258627849914435	no	1283	0.238847848079685	819	NA					Putative protein of unknown function; potential Cdc28p substrate; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2	biological_process	molecular_function	cellular_component
YHR131C_p	YHR131C	YHR131C	hom	Uncharacterized	0.64722065485165	0.258744572635234	no	1284	0.23368770769817	781	NA					Putative protein of unknown function; GFP-fusion protein localizes to the cytoplasm; overexpression causes cell cycle delay or arrest; contains a PH domain and binds phosphatidylinositols and other lipids in a large-scale study	biological_process	molecular_function	cytoplasm
YCL039W	YCL039W	GID7	hom	Verified	0.646500983816023	0.258977480095187	no	1285	0.254592448065096	849	NA	FT	KETONE METABOLISM|CARBOHYDRATE METABOLISM|PROTEOLYSIS	NUCLEUS		Subunit of GID Complex that binds directly to central component Vid30p; GID complex is involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; Gid7p contains six WD40 repeats; computational analysis suggests that Gid7p and Moh1p have similar functions	negative regulation of gluconeogenesis|proteasomal ubiquitin-dependent protein catabolic process	molecular_function	nucleus|GID complex|cytoplasm
YIL066C	YIL066C	RNR3	hom	Verified	0.646117275926971	0.259101703956989	no	1286	0.254578883867908	897	NA	FT	OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM	MITOCHONDRION		Minor isoform of the large subunit of ribonucleotide-diphosphate reductase; the RNR complex catalyzes rate-limiting step in dNTP synthesis, regulated by DNA replication and DNA damage checkpoint pathways via localization of small subunits	deoxyribonucleotide biosynthetic process	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	mitochondrion|ribonucleoside-diphosphate reductase complex|cytoplasm
YHR181W	YHR181W	SVP26	hom	Verified	0.646053979559472	0.259122198857293	no	1287	0.252550327646059	880	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Integral membrane protein of the early Golgi apparatus and endoplasmic reticulum, involved in COP II vesicle transport; may also function to promote retention of proteins in the early Golgi compartment	protein retention in Golgi apparatus|fungal-type cell wall organization|protein glycosylation|ER to Golgi vesicle-mediated transport	COPII adaptor activity	integral to endoplasmic reticulum membrane|integral to membrane|endoplasmic reticulum|integral to Golgi membrane|ER to Golgi transport vesicle
YMR072W	YMR072W	ABF2	hom	Verified	0.645423631801667	0.259326346570908	no	1288	0.265028785414229	905	NA	FT	MITOCHONDRION ORGANIZATION	NUCLEUS|MITOCHONDRION|CHROMOSOME		Mitochondrial DNA-binding protein involved in mitochondrial DNA replication and recombination, member of HMG1 DNA-binding protein family; activity may be regulated by protein kinase A phosphorylation	mitochondrion inheritance|mitochondrial DNA packaging|mitochondrial genome maintenance	DNA binding, bending|DNA binding	mitochondrial nucleoid|mitochondrial chromosome|mitochondrion
YIL134C-A_p	YIL134C-A	YIL134C-A	hom	Uncharacterized	0.644386689596645	0.25966235679263	no	1289	0.252027530583363	865	NA					Putative protein of unknown function; identified by fungal homology and RT-PCR	biological_process	molecular_function	cellular_component
YLR380W	YLR380W	CSR1	hom	Verified	0.644062227798801	0.259767541370424	no	1290	0.236643978101735	804	NA	FT	KETONE METABOLISM|LIPID METABOLISM|CELL WALL ORG/BIOGENESIS	MITOCHONDRION		Phosphatidylinositol transfer protein; has a potential role in regulating lipid and fatty acid metabolism under heme-depleted conditions; interacts specifically with thioredoxin peroxidase; may have a role in oxidative stress resistance; protein abundance increases in response to DNA replication stress	phosphatidylinositol metabolic process|Golgi to plasma membrane protein transport|Golgi to plasma membrane transport|Unknown|negative regulation of fatty acid biosynthetic process|phospholipid transport	phosphatidylinositol transporter activity|phosphatidylcholine transporter activity	cytosol|endosome|mitochondrion|lipid particle
YMR158W-B_d	YMR158W-B	YMR158W-B	hom	Dubious	0.642920764961679	0.260137757397155	no	1291	0.240066822719249	829	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene ATG16/YMR159C	Unknown	Unknown	Unknown
YKR074W	YKR074W	AIM29	hom	Verified	0.642169493008539	0.260381569300279	no	1292	0.246275993565	850	NA					Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm; YKR074W is not an essential gene; null mutant displays elevated frequency of mitochondrial genome loss	biological_process	molecular_function	cytoplasm
YER053C-A	YER053C-A	YER053C-A	hom	Verified	0.640306887296018	0.2609865520111	no	1293	0.23982042910413	812	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	endoplasmic reticulum
YMR139W	YMR139W	RIM11	hom	Verified	0.639124882530901	0.261370846998896	no	1294	0.221508683681581	763	NA	FT	PROTEOLYSIS|PROTEIN PHOSPHORYLATION			Protein kinase; required for signal transduction during entry into meiosis; promotes the formation of the Ime1p-Ume6p complex by phosphorylating Ime1p and Ume6p; shares similarity with mammalian glycogen synthase kinase 3-beta; protein abundance increases in response to DNA replication stress	proteolysis|ascospore formation|protein phosphorylation|response to stress	protein serine/threonine kinase activity|protein kinase activity	cytoplasm
YKL038W	YKL038W	RGT1	hom	Verified	0.638675511991827	0.261517023168037	no	1295	0.286698864741035	980	NA	FT	TRANSCRIPTION FROM RNA POL II|CARBOHYDRATE METABOLISM	NUCLEUS		Glucose-responsive transcription factor; regulates expression of several glucose transporter (HXT) genes in response to glucose; binds to promoters and acts both as a transcriptional activator and repressor; RGT1 has a paralog, EDS1, that arose from the whole genome duplication	glucose transport|regulation of glucose import|negative regulation of transcription from RNA polymerase II promoter|glucose metabolic process|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription	nucleus
YLR232W_d	YLR232W	YLR232W	hom	Dubious	0.638414651729259	0.261601897899827	no	1296	0.245941948585926	844	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene BNA5	Unknown	Unknown	Unknown
YJL208C	YJL208C	NUC1	hom	Verified	0.637351170064721	0.261948063588229	no	1297	0.263378733331154	902	NA	FT		NUCLEUS|MITOCHONDRION		Major mitochondrial nuclease, has RNAse and DNA endo- and exonucleolytic activities; has roles in mitochondrial recombination, apoptosis and maintenance of polyploidy	DNA catabolic process|RNA catabolic process|apoptotic process|DNA recombination	ribonuclease activity|endodeoxyribonuclease activity|exodeoxyribonuclease activity	mitochondrion|mitochondrial inner membrane|nucleus
YMR111C	YMR111C	YMR111C	hom	Verified	0.637085339036319	0.262034628866243	no	1298	0.237303109595164	764	NA	FT		NUCLEUS		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR111C is not an essential gene; forms nuclear foci upon DNA replication stress	biological_process	molecular_function	nucleus
YDR248C_p	YDR248C	YDR248C	hom	Uncharacterized	0.634947362402536	0.262731372909298	no	1299	0.246688550475201	836	NA	FT	KETONE METABOLISM|CARBOHYDRATE METABOLISM			Putative gluconokinase; sequence similarity to bacterial and human gluconokinase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; upregulated by deletion of the RNAP-II associated factor, PAF1	biological_process	molecular_function	cytoplasm
YOR331C_d	YOR331C	YOR331C	hom	Dubious	0.63475762254527	0.262793252881965	no	1300	0.316985860278442	1056	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene VMA4/YOR332W	Unknown	Unknown	Unknown
YMR083W	YMR083W	ADH3	hom	Verified	0.634530789838724	0.262867239748745	no	1301	0.270948013252754	938	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Mitochondrial alcohol dehydrogenase isozyme III; involved in the shuttling of mitochondrial NADH to the cytosol under anaerobic conditions and ethanol production	NADH oxidation|fermentation|amino acid catabolic process to alcohol via Ehrlich pathway	alcohol dehydrogenase (NAD) activity	mitochondrion|mitochondrial matrix
YJL016W_p	YJL016W	YJL016W	hom	Uncharacterized	0.633992697014471	0.263042794077589	no	1302	0.268509088125381	902	NA					Putative protein of unknown function; GFP-fusion protein localizes to the cytoplasm; conserved in closely related Saccharomyces species	biological_process	molecular_function	cytoplasm
YOL048C	YOL048C	RRT8	hom	Verified	0.633820083286276	0.263099122493078	no	1303	0.256437687884142	857	NA					Protein of unknown function; identified in a screen for mutants with increased levels of rDNA transcription; green fluorescent protein (GFP)-fusion protein localizes to lipid particles; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	integral to membrane|lipid particle
YHR112C	YHR112C	YHR112C	hom	Verified	0.631001558531118	0.264019752693092	no	1304	0.256687136575876	902	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Protein of unknown function; localizes to the cytoplasm and nucleus; overexpression affects protein trafficking through the endocytic pathway	sulfur compound metabolic process	cystathionine beta-lyase activity	nucleus|cytoplasm
YJR116W_p	YJR116W	TDA4	hom	Uncharacterized	0.630361743697154	0.264228967309228	no	1305	0.211501814892473	718	NA					Putative protein of unknown function; null mutant is sensitive to expression of the top1-T722A allele	biological_process	molecular_function	integral to membrane
YJR117W	YJR117W	STE24	hom	Verified	0.629195554765825	0.264610519347805	no	1306	0.246554896103691	824	NA	FT	PROTEOLYSIS	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|MITOCHONDRION		Highly conserved zinc metalloprotease that functions in two steps of a-factor maturation, C-terminal CAAX proteolysis and the first step of N-terminal proteolytic processing; contains multiple transmembrane spans	CAAX-box protein processing|peptide pheromone maturation	metalloendopeptidase activity	mitochondrial outer membrane|integral to endoplasmic reticulum membrane|integral to membrane|nuclear inner membrane
YNL140C_p	YNL140C	YNL140C	hom	Uncharacterized	0.627925265650631	0.265026449413487	no	1307	0.309478584135958	1048	NA					Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps THO2/YNL139C	biological_process	molecular_function	cellular_component
YIR030C	YIR030C	DCG1	hom	Verified	0.626899276042205	0.265362630935724	no	1308	0.257741017653248	930	NA					Protein of unknown function, expression is sensitive to nitrogen catabolite repression and regulated by Dal80p; contains transmembrane domain	nitrogen compound metabolic process	molecular_function	cellular_component
YPL109C_p	YPL109C	YPL109C	hom	Uncharacterized	0.626070516674108	0.265634344824192	no	1309	0.250178199430234	882	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YOR378W_p	YOR378W	YOR378W	hom	Uncharacterized	0.62563059367113	0.265778633606136	no	1310	0.247447211075052	844	NA	FT		PLASMA MEMBRANE		Putative paralog of ATR1, but not required for boron tolerance; member of the DHA2 family of drug:H+ antiporters; YOR378W is not an essential gene	biological_process	molecular_function	integral to membrane
YPL189C-A	YPL189C-A	COA2	hom	Verified	0.623543860995833	0.266463594373239	no	1311	0.262714523692459	872	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Cytochrome oxidase assembly factor; null mutation results in respiratory deficiency with specific loss of cytochrome oxidase activity; functions downstream of assembly factors Mss51p and Coa1p and interacts with assembly factor Shy1p	mitochondrial respiratory chain complex IV assembly	molecular_function	mitochondrial matrix
YER085C_p	YER085C	YER085C	hom	Uncharacterized	0.622860899153995	0.26668796737226	no	1312	0.246120432729414	850	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YOR298C-A	YOR298C-A	MBF1	hom	Verified	0.621997384582924	0.266971793890802	no	1313	0.234592128160559	789	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS|MITOCHONDRION		Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress	positive regulation of transcription from RNA polymerase II promoter	transcription coactivator activity	mitochondrion|nucleus
YPL030W	YPL030W	TRM44	hom	Verified	0.621633011640167	0.267091604507776	no	1314	0.250144038712696	857	NA	FT	RNA PROCESSING			tRNA(Ser) Um(44) 2'-O-methyltransferase; involved in maintaining levels of the tRNA-Ser species tS(CGA) and tS(UGA); conserved among metazoans and fungi but there does not appear to be a homolog in plants; TRM44 is a non-essential gene	tRNA methylation	tRNA (uracil) methyltransferase activity	cytoplasm
YGL227W	YGL227W	VID30	hom	Verified	0.621047213145354	0.267284279647206	no	1315	0.26854049269676	902	NA	FT	KETONE METABOLISM|CARBOHYDRATE METABOLISM|PROTEOLYSIS	NUCLEUS		Central component of GID Complex, involved in FBPase degradation; interacts strongly with Gid8p to serve as a scaffold for other GID Complex subunits; contains SPRY domain and 3 domains that are also found in Gid8p - LisH, CTLH, and CRA; required for association of Vid vesicles and actin patches in vacuole import and degradation pathway; shifts the balance of nitrogen metabolism toward glutamate production; localizes to the nucleus and the cytoplasm	regulation of nitrogen utilization|negative regulation of gluconeogenesis|proteasomal ubiquitin-dependent protein catabolic process|vacuolar protein catabolic process	molecular_function	nucleus|GID complex|cytoplasm
YKR099W	YKR099W	BAS1	hom	Verified	0.620484068049636	0.267469569946802	no	1316	0.272460146206214	899	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Myb-related transcription factor involved in regulating basal and induced expression of genes of the purine and histidine biosynthesis pathways; also involved in regulation of meiotic recombination at specific genes	positive regulation of transcription from RNA polymerase II promoter	core promoter sequence-specific DNA binding|sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|RNA polymerase II transcription factor recruiting transcription factor activity	nucleus
YKR084C	YKR084C	HBS1	hom	Verified	0.620407926011966	0.267494627751951	no	1317	0.274917343823647	939	NA	FT	TRANSLATION|NUCLEOTIDE METABOLISM			GTPase with similarity to translation release factors; together with binding partner Dom34p, facilitates ribosomal subunit dissociation and peptidyl-tRNA release when translation is stalled; genetically implicated in mRNA no-go decay	nuclear-transcribed mRNA catabolic process, no-go decay|ribosome disassembly|nonfunctional rRNA decay	ribosome binding|GTPase activity	cytoplasm
YLR434C_d	YLR434C	YLR434C	hom	Dubious	0.620343914340755	0.267515694455325	no	1318	0.285886527049233	963	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF TSR2/YLR435W	Unknown	Unknown	Unknown
YNL042W-B_p	YNL042W-B	YNL042W-B	hom	Uncharacterized	0.620336322068602	0.267518193182429	no	1319	0.241682463581854	847	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YOR296W_p	YOR296W	YOR296W	hom	Uncharacterized	0.620206941213864	0.267560776110986	no	1320	0.230647430355332	793	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; expressed during copper starvation; YOR296W is not an essential gene	biological_process	molecular_function	cytoplasm
YBR218C	YBR218C	PYC2	hom	Verified	0.620200693637891	0.267562832452877	no	1321	0.280277929169689	943	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM			Pyruvate carboxylase isoform; cytoplasmic enzyme that converts pyruvate to oxaloacetate; differentially regulated than isoform Pyc1p; mutations in the human homolog are associated with lactic acidosis; PYC2 has a paralog, PYC1, that arose from the whole genome duplication	NADPH regeneration|gluconeogenesis	pyruvate carboxylase activity	cytosol
YBR295W	YBR295W	PCA1	hom	Verified	0.619003559054284	0.26795700713467	no	1322	0.26180022129614	894	NA	FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS	PLASMA MEMBRANE		Cadmium transporting P-type ATPase; may also have a role in copper and iron homeostasis; stabilized by Cd binding, which prevents ubiquitination; S288C and other lab strains contain a G970R mutation which eliminates Cd transport function	cadmium ion transport|cellular iron ion homeostasis|cellular metal ion homeostasis|transmembrane transport	copper-transporting ATPase activity|cadmium-exporting ATPase activity|copper ion binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism	integral to membrane|plasma membrane
YNR051C	YNR051C	BRE5	hom	Verified	0.61874930765185	0.268040760888883	no	1323	0.266352123681682	943	NA	FT	VESICLE-MEDIATED TRANSPORT			Ubiquitin protease cofactor, forms deubiquitination complex with Ubp3p that coregulates anterograde and retrograde transport between the endoplasmic reticulum and Golgi compartments; null is sensitive to brefeldin A	protein deubiquitination|ribophagy|regulation of ER to Golgi vesicle-mediated transport|Unknown	molecular_function	cytoplasm
YPL258C	YPL258C	THI21	hom	Verified	0.618210496630632	0.268218295869624	no	1324	0.262252529903202	917	NA					Hydroxymethylpyrimidine (HMP) and HMP-phosphate kinase; involved in thiamine biosynthesis; member of a gene family with THI20 and THI22; functionally redundant with Thi20p	thiamine biosynthetic process	phosphomethylpyrimidine kinase activity|hydroxymethylpyrimidine kinase activity	cellular_component
YCR094W	YCR094W	CDC50	hom	Verified	0.617668011326727	0.268397101257154	no	1325	0.312370282807432	1076	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION	GOLGI APPARATUS		Endosomal protein that interacts with phospholipid flippase Drs2p; interaction with Cdc50p is essential for Drs2p catalytic activity; mutations affect cell polarity and polarized growth; similar to Lem3p; CDC50 has a paralog, YNR048W, that arose from the whole genome duplication	intracellular protein transport|phospholipid translocation|endocytosis|actin cortical patch localization	phospholipid-translocating ATPase activity	trans-Golgi network|late endosome membrane
YCR017C	YCR017C	CWH43	hom	Verified	0.61724367171078	0.268537007110412	no	1326	0.318995441201431	1080	NA	FT	LIPID METABOLISM|CELL WALL ORG/BIOGENESIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Putative sensor/transporter protein involved in cell wall biogenesis; contains 14-16 transmembrane segments and several putative glycosylation and phosphorylation sites; null mutation is synthetically lethal with pkc1 deletion	fungal-type cell wall organization|GPI anchor biosynthetic process	molecular_function	integral to membrane|integral to plasma membrane|cellular bud neck|cellular bud tip
YLR048W	YLR048W	RPS0B	hom	Verified	0.61647370292253	0.268790961354834	no	1327	0.238442859043436	808	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; RPS0B has a paralog, RPS0A, that arose from the whole genome duplication; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2	cytoplasmic translation|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|rRNA export from nucleus|ribosomal small subunit assembly|endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome	cytosolic small ribosomal subunit
YDR230W_d	YDR230W	YDR230W	hom	Dubious	0.615840303077128	0.268999962267813	no	1328	0.243855771394867	843	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20	Unknown	Unknown	Unknown
YKL067W	YKL067W	YNK1	hom	Verified	0.615273180998789	0.269187162909791	no	1329	0.239352098003023	804	NA	FT	RESPONSE TO DNA DAMAGE|NUCLEOTIDE METABOLISM	MITOCHONDRION		Nucleoside diphosphate kinase; catalyzes the transfer of gamma phosphates from nucleoside triphosphates, usually ATP, to nucleoside diphosphates by a mechanism that involves formation of an autophosphorylated enzyme intermediate; protein abundance increases in response to DNA replication stress	nucleoside diphosphate phosphorylation|nucleoside triphosphate biosynthetic process|response to DNA damage stimulus	nucleoside diphosphate kinase activity	cytosol|mitochondrion|mitochondrial intermembrane space
YPL009C	YPL009C	TAE2	hom	Verified	0.61489202840641	0.269313013820448	no	1330	0.268411388996789	930	NA	FT	TRANSLATION			Protein of unknown function, involved in protein translation; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	cytoplasmic translation	molecular_function	ribosome|cytoplasm
YOR279C	YOR279C	RFM1	hom	Verified	0.612822860620685	0.269996736669503	no	1331	0.303494137137257	1036	NA	FT	GENE SILENCING	NUCLEUS		DNA-binding protein required for vegetative repression of middle sporulation genes; specificity factor that directs the Hst1p histone deacetylase to some of the promoters regulated by Sum1p; involved in telomere maintenance	chromatin silencing|chromatin silencing at silent mating-type cassette	unfolded protein binding	histone deacetylase complex|nucleus
YGR018C_p	YGR018C	YGR018C	hom	Uncharacterized	0.61224320504335	0.270188430064558	no	1332	0.244755869204827	824	NA					Protein of unknown function; mRNA identified as translated by ribosome profiling data; partially overlaps the uncharacterized ORF YGR017W	biological_process	molecular_function	cellular_component
YLR135W	YLR135W	SLX4	hom	Verified	0.612186930875662	0.270207043681724	no	1333	0.25716925474749	864	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Endonuclease involved in processing DNA; acts during recombination and repair; cleaves branched structures in a complex with Slx1p; involved interstrand cross-link repair and in Rad1p/Rad10p-dependent removal of 3'-nonhomologous tails during DSBR via single-strand annealing; relative distribution to nuclear foci increases upon DNA replication stress	double-strand break repair via single-strand annealing, removal of nonhomologous ends|DNA replication|response to DNA damage stimulus|DNA-dependent DNA replication	5'-flap endonuclease activity	Slx1-Slx4 complex|nucleus
YDR110W	YDR110W	FOB1	hom	Verified	0.611381236441722	0.270473610816242	no	1334	0.263754981120411	882	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|CHROMATIN ORGANIZATION|CHROMOSOME SEGREGATION|GENE SILENCING	NUCLEUS|CHROMOSOME		Nucleolar protein that binds the rDNA replication fork barrier (RFB) site; required for replication fork blocking, recombinational hotspot activity, condensin recruitment to RFB and rDNA repeat segregation; related to retroviral integrases	extrachromosomal circular DNA accumulation involved in cell aging|negative regulation of DNA replication|rDNA condensation|chromatin silencing at rDNA|replicative cell aging|protein localization to nucleolar rDNA repeats|DNA recombination	rDNA spacer replication fork barrier binding	nucleolus|rDNA heterochromatin
YLL026W	YLL026W	HSP104	hom	Verified	0.610973079242027	0.270608701339568	no	1335	0.273938893589034	945	NA	FT	PROTEIN LOCALIZATION|CARBOHYDRATE METABOLISM|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		Disaggregase; heat shock protein that cooperates with Ydj1p (Hsp40) and Ssa1p (Hsp70) to refold and reactivate previously denatured, aggregated proteins; responsive to stresses including: heat, ethanol, and sodium arsenite; involved in [PSI+] propagation; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress	trehalose metabolism in response to heat stress|protein folding in endoplasmic reticulum|protein unfolding|chaperone cofactor-dependent protein refolding|inheritance of oxidatively modified proteins involved in replicative cell aging|cellular heat acclimation	ADP binding|unfolded protein binding|ATPase activity, coupled|chaperone binding|ATP binding	TRC complex|nucleus|cytoplasm
YER060W	YER060W	FCY21	hom	Verified	0.609515672817136	0.271091343748705	no	1336	0.263581868598289	909	NA					Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function	transmembrane transport	nucleobase transmembrane transporter activity	integral to membrane
YDR502C	YDR502C	SAM2	hom	Verified	0.608931606820149	0.271284886557326	no	1337	0.247781133387074	820	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM			S-adenosylmethionine synthetase; catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; SAM2 has a paralog, SAM1, that arose from the whole genome duplication	methionine metabolic process|S-adenosylmethionine biosynthetic process	methionine adenosyltransferase activity	cellular_component
YLR386W	YLR386W	VAC14	hom	Verified	0.608451899796497	0.271443899275199	no	1338	0.305850664062717	1075	NA	FT	PROTEIN LOCALIZATION|LIPID METABOLISM			Protein involved in regulated synthesis of PtdIns(3,5)P(2), in control of trafficking of some proteins to the vacuole lumen via the MVB, and in maintenance of vacuole size and acidity; interacts with Fig4p; activator of Fab1p	phosphatidylinositol biosynthetic process|positive regulation of kinase activity	protein binding, bridging	fungal-type vacuole membrane|PAS complex|extrinsic to vacuolar membrane
YML116W	YML116W	ATR1	hom	Verified	0.608045818644211	0.27157854285631	no	1339	0.227240647657585	738	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Multidrug efflux pump of the major facilitator superfamily; required for resistance to aminotriazole and 4-nitroquinoline-N-oxide; ATR1 has a paralog, YMR279C, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress	borate transport|drug transmembrane transport	drug transmembrane transporter activity|borate transmembrane transporter activity	integral to membrane|plasma membrane|vacuole
YLR224W_p	YLR224W	YLR224W	hom	Uncharacterized	0.608041798409824	0.271579876004274	no	1340	0.252020697535076	856	NA	FT	PROTEOLYSIS			F-box protein and component of SCF ubiquitin ligase complexes involved in ubiquitin-dependent protein catabolism; readily monoubiquitinated in vitro by SCF-Ubc4 complexes; YLR224W is not an essential gene	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|cellular response to methylmercury	ubiquitin-protein ligase activity|protein binding, bridging	SCF ubiquitin ligase complex
YOR251C	YOR251C	TUM1	hom	Verified	0.605494935430448	0.272425094397213	no	1341	0.238118661026782	838	NA	FT	RNA PROCESSING	MITOCHONDRION		Rhodanese domain sulfur transferase, accepts persulfite from Nfs1p and transfers it to Uba4p in the pathway for 2-thiolation of the wobble uridine base of tRNAs; also stimulates sulfur transfer by Nfs1p; may be mitochondrially localized	tRNA wobble position uridine thiolation|tRNA wobble uridine modification	thiosulfate sulfurtransferase activity	cytoplasm
YOL122C	YOL122C	SMF1	hom	Verified	0.60431067320979	0.272818555805263	no	1342	0.259969027687824	885	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Divalent metal ion transporter with a broad specificity for di-valent and tri-valent metals; post-translationally regulated by levels of metal ions; member of the Nramp family of metal transport proteins	copper ion transport|cellular copper ion homeostasis|manganese ion transport|cadmium ion transport|cellular manganese ion homeostasis|cellular cadmium ion homeostasis|iron ion transport	solute:hydrogen symporter activity|inorganic cation transmembrane transporter activity	integral to membrane|plasma membrane
YLR279W_d	YLR279W	YLR279W	hom	Dubious	0.604305221729506	0.27282036766646	no	1343	0.287834154192956	1007	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YOR382W	YOR382W	FIT2	hom	Verified	0.603407632202591	0.273118773082997	no	1344	0.235895206368545	784	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall	siderophore transport	molecular_function	fungal-type cell wall
YPL115C	YPL115C	BEM3	hom	Verified	0.60331709711068	0.273148880631661	no	1345	0.296648104054908	1010	NA	FT	SIGNALING	SITE OF POLARIZED GROWTH		Rho GTPase activating protein (RhoGAP) involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assembly	negative regulation of Rho protein signal transduction|establishment of cell polarity	Rho GTPase activator activity|phosphatidylinositol-3-phosphate binding	cell cortex|incipient cellular bud site|mating projection tip|cytoplasm|cellular bud tip
YDR346C	YDR346C	SVF1	hom	Verified	0.601934925295541	0.273608727565488	no	1346	0.29996953896898	1027	NA	FT	RESPONSE TO OXIDATIVE STRESS	NUCLEUS		Protein with a potential role in cell survival pathways, required for the diauxic growth shift; expression in mammalian cells increases survival under conditions inducing apoptosis; mutant has increased aneuploidy tolerance	cellular response to oxidative stress	molecular_function	nucleus|cytoplasm
YOR008C	YOR008C	SLG1	hom	Verified	0.601602228415541	0.273719472598467	no	1347	0.329141407375169	1135	NA	FF|FT	VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|SIGNALING|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION|PEROXISOME ORGANIZATION	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON		Sensor-transducer of the stress-activated PKC1-MPK1 kinase pathway; involved in maintenance of cell wall integrity; required for mitophagy; involved in organization of the actin cytoskeleton; secretory pathway Wsc1p is required for the arrest of secretion response	positive regulation of endocytosis|Rho protein signal transduction|actin cytoskeleton organization|fungal-type cell wall organization|response to heat|peroxisome degradation|establishment of cell polarity|response to osmotic stress	transmembrane signaling receptor activity	plasma membrane|mating projection tip|cellular bud neck
YOR253W	YOR253W	NAT5	hom	Verified	0.600932677046825	0.273942413800613	no	1348	0.274581464347882	946	NA	FT			RIBOSOME	Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing	N-terminal protein amino acid acetylation	peptide alpha-N-acetyltransferase activity	NatA complex|cytosolic ribosome
YLR047C	YLR047C	FRE8	hom	Verified	0.600044820569779	0.274238182634334	no	1349	0.305842371634665	1057	NA	FT	ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|GEN. OF PRECURSOR METABOLITES AND ENERGY			Protein with sequence similarity to iron/copper reductases, involved in iron homeostasis; deletion mutant has iron deficiency/accumulation growth defects; expression increased in the absence of copper-responsive transcription factor Mac1p	cellular metal ion homeostasis	oxidoreductase activity, oxidizing metal ions	integral to membrane|membrane
YNL209W	YNL209W	SSB2	hom	Verified	0.599521749718405	0.274412505371224	no	1350	0.213967352473865	698	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RESPONSE TO NUTRIENT LEVELS			Cytoplasmic ATPase that is a ribosome-associated molecular chaperone; functions with J-protein partner Zuo1p; may be involved in the folding of newly-synthesized polypeptide chains; member of the HSP70 family; SSB2 has a paralog, SSB1, that arose from the whole genome duplication	cellular response to glucose starvation|cytoplasmic translation|ribosomal subunit export from nucleus|rRNA processing|regulation of translational fidelity|'de novo' cotranslational protein folding	unfolded protein binding|ATPase activity	plasma membrane|polysome|cytoplasm
YOL105C	YOL105C	WSC3	hom	Verified	0.599446154190848	0.274437703458363	no	1351	0.256179433700414	918	NA	FT	SIGNALING|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION|PEROXISOME ORGANIZATION	SITE OF POLARIZED GROWTH		Partially redundant sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway involved in maintenance of cell wall integrity; involved in the response to heat shock and other stressors; regulates 1,3-beta-glucan synthesis	response to heat|peroxisome degradation|Rho protein signal transduction	transmembrane signaling receptor activity	mating projection tip
YJR139C	YJR139C	HOM6	hom	Verified	0.597526891093904	0.275077829372007	no	1352	0.292670793824253	1020	NA	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS	NUCLEUS		Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase), dimeric enzyme that catalyzes the third step in the common pathway for methionine and threonine biosynthesis; enzyme has nucleotide-binding, dimerization and catalytic regions	threonine biosynthetic process|methionine biosynthetic process|homoserine biosynthetic process	homoserine dehydrogenase activity	nucleus|cytoplasm
YMR182W-A_p	YMR182W-A	YMR182W-A	hom	Uncharacterized	0.59699312741218	0.275255984539359	no	1353	0.242593114528123	837	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YBL094C_d	YBL094C	YBL094C	hom	Dubious	0.594929730282104	0.275945221640824	no	1354	0.264756637952179	912	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized ORF YBL095W	Unknown	Unknown	Unknown
YDL061C	YDL061C	RPS29B	hom	Verified	0.592486293942628	0.276762498056122	no	1355	0.261229279149232	897	NA	FT	TRANSLATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S29 and bacterial S14; RPS29B has a paralog, RPS29A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic small ribosomal subunit
YDR423C	YDR423C	CAD1	hom	Verified	0.588840163694632	0.277984250161402	no	1356	0.28773865833209	996	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		AP-1-like basic leucine zipper (bZIP) transcriptional activator; involved in stress responses, iron metabolism, and pleiotropic drug resistance; controls a set of genes involved in stabilizing proteins; binds consensus sequence TTACTAA; CAD1 has a paralog, YAP1, that arose from the whole genome duplication	cellular response to cadmium ion|positive regulation of transcription from RNA polymerase II promoter in response to stress|positive regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus|cytoplasm
YOL004W	YOL004W	SIN3	hom	Verified	0.587911847713202	0.278295731819298	no	1357	0.280360900701608	960	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|CELL DIVISION|GENE SILENCING	NUCLEUS|CHROMOSOME		Component of the Sin3p-Rpd3p histone deacetylase complex, involved in transcriptional repression and activation of diverse processes, including mating-type switching and meiosis; involved in the maintenance of chromosomal integrity	positive regulation of transcription from RNA polymerase II promoter in response to heat stress|negative regulation of chromatin silencing at rDNA|histone deacetylation|negative regulation of chromatin silencing at silent mating-type cassette|negative regulation of transcription from RNA polymerase I promoter|negative regulation of transcription during meiosis|regulation of DNA-dependent DNA replication initiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of chromatin silencing at telomere|double-strand break repair via nonhomologous end joining|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription involved in G2/M-phase of mitotic cell cycle	transcription coactivator activity|transcription corepressor activity	Sin3-type complex|Rpd3S complex|Rpd3L-Expanded complex|Rpd3L complex
YKL164C	YKL164C	PIR1	hom	Verified	0.584878199761603	0.279314809000061	no	1358	0.267851876250454	919	NA	FT	PROTEIN LOCALIZATION|CELL WALL ORG/BIOGENESIS			O-glycosylated protein required for cell wall stability; attached to the cell wall via beta-1,3-glucan; mediates mitochondrial translocation of Apn1p; expression regulated by the cell integrity pathway and by Swi5p during the cell cycle; PIR1 has a paralog, YJL160C, that arose from the whole genome duplication	intracellular protein transport|fungal-type cell wall organization	structural constituent of cell wall	fungal-type cell wall
YDR072C	YDR072C	IPT1	hom	Verified	0.584191263692811	0.279545819290508	no	1359	0.278533993434521	968	NA	FT	LIPID METABOLISM			Inositolphosphotransferase, involved in synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C), the most abundant sphingolipid; can mutate to resistance to the antifungals syringomycin E and DmAMP1 and to K. lactis zymocin	mannosyl diphosphorylinositol ceramide metabolic process|sphingolipid biosynthetic process	transferase activity, transferring phosphorus-containing groups	integral to membrane
YKR072C	YKR072C	SIS2	hom	Verified	0.583828286934883	0.279667922486847	no	1360	0.321785894219638	1101	NA	FF|FT	CELL CYCLE|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM	NUCLEUS		Negative regulatory subunit of protein phosphatase 1 Ppz1p and also a subunit of the phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis	regulation of mitotic cell cycle|response to salt stress|coenzyme A biosynthetic process	phosphopantothenoylcysteine decarboxylase activity|protein phosphatase inhibitor activity	phosphopantothenoylcysteine decarboxylase complex|nucleus|cytoplasm
YHL016C	YHL016C	DUR3	hom	Verified	0.583253428120934	0.279861354473632	no	1361	0.257359881749295	871	NA	FT		PLASMA MEMBRANE		Plasma membrane transporter for both urea and polyamines, expression is highly sensitive to nitrogen catabolite repression and induced by allophanate, the last intermediate of the allantoin degradative pathway	urea transport|spermidine transport|putrescine transport|urea catabolic process	urea transmembrane transporter activity|spermidine transmembrane transporter activity|putrescine transmembrane transporter activity	integral to membrane|plasma membrane
YOR293C-A_p	YOR293C-A	YOR293C-A	hom	Uncharacterized	0.582568734369897	0.280091829024761	no	1362	0.262685202625232	869	NA					Putative protein of unknown function; identified by expression profiling and mass spectrometry	biological_process	molecular_function	cellular_component
YOR280C	YOR280C	FSH3	hom	Verified	0.582232962241423	0.280204886783846	no	1363	0.277430016931454	944	NA					Putative serine hydrolase; likely target of Cyc8p-Tup1p-Rfx1p transcriptional regulation; sequence is similar to S. cerevisiae Fsh1p and Fsh2p and the human candidate tumor suppressor OVCA2	biological_process	molecular_function	cellular_component
YPL232W	YPL232W	SSO1	hom	Verified	0.58117224339237	0.280562186365244	no	1364	0.286768596574353	1004	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION	PLASMA MEMBRANE		Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane and in vesicle fusion during sporulation; forms a complex with Sec9p that binds v-SNARE Snc2p; syntaxin homolog; functionally redundant with Sso2p	ascospore formation|ascospore-type prospore assembly|vesicle fusion	phosphatidic acid binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|SNAP receptor activity	SNARE complex|fungal-type vacuole membrane|plasma membrane|prospore membrane
YDL059C	YDL059C	RAD59	hom	Verified	0.580673037838466	0.280730418342732	no	1365	0.297149596267065	1022	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		Protein involved DNA double-strand break repair; repairs breaks in DNA during vegetative growth via recombination and single-strand annealing; anneals complementary single-stranded DNA; forms nuclear foci upon DNA replication stress; required for loading of Rad52p to DSBs; paralog of Rad52p	DNA strand renaturation|telomere maintenance via recombination|double-strand break repair via break-induced replication|double-strand break repair via single-strand annealing	protein binding	nucleus
YFR032C_p	YFR032C	RRT5	hom	Uncharacterized	0.580281215565884	0.280862496383516	no	1366	0.27717228130629	970	NA					Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; expressed at high levels during sporulation	biological_process	molecular_function	cellular_component
YOR293W	YOR293W	RPS10A	hom	Verified	0.579761932217487	0.281037586121524	no	1367	0.240923582259638	798	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10A has a paralog, RPS10B, that arose from the whole genome duplication	cytoplasmic translation|rRNA export from nucleus	structural constituent of ribosome	cytosolic small ribosomal subunit
YER020W	YER020W	GPA2	hom	Verified	0.578921288947484	0.281321142364877	no	1368	0.260693734351975	896	NA	FT	SIGNALING|NUCLEOTIDE METABOLISM	MITOCHONDRION|PLASMA MEMBRANE		Nucleotide binding alpha subunit of the heterotrimeric G protein that interacts with the receptor Gpr1p, has signaling role in response to nutrients; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery	adenylate cyclase-activating G-protein coupled receptor signaling pathway|ascospore formation|replicative cell aging|signal transduction|glucose mediated signaling pathway|pseudohyphal growth|hexose mediated signaling|regulation of cell size	GTPase activity	mitochondrion|plasma membrane
YDR291W	YDR291W	HRQ1	hom	Verified	0.578788137129375	0.281366068290835	no	1369	0.272112475717873	897	NA	FT		NUCLEUS		3'-5'DNA helicase that has DNA strand annealing activity; helicase activity is stimulated by fork structure and 3'-tail length of substrates; belongs to the widely conserved RecQ family of proteins which are involved in maintaining genomic integrity; similar to the human RecQ4p implicated in Rothmund-Thomson syndrome(RTS)	biological_process	molecular_function	nucleus
YPR152C	YPR152C	URN1	hom	Verified	0.578627535020739	0.281420260655083	no	1370	0.27689946460686	959	NA	FT	RNA PROCESSING	NUCLEUS		Putative protein of unknown function containing WW and FF domains; overexpression causes accumulation of cells in G1 phase	biological_process	molecular_function	nucleus
YLL042C	YLL042C	ATG10	hom	Verified	0.5771885795996	0.281906035519842	no	1371	0.260205966768621	895	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS			Conserved E2-like conjugating enzyme that mediates formation of the Atg12p-Atg5p conjugate, which is a critical step in autophagy	piecemeal microautophagy of nucleus|cellular protein modification process|mitochondrion degradation|macroautophagy|CVT pathway	Atg12 ligase activity	cellular_component
YNL170W_d	YNL170W	YNL170W	hom	Dubious	0.577119700480092	0.281929298449529	no	1372	0.286193285610175	1030	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YEL003W	YEL003W	GIM4	hom	Verified	0.576703707330612	0.282069813794188	no	1373	0.276062942789181	943	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS			Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it	tubulin complex assembly	tubulin binding	prefoldin complex|cytoplasm
YLR460C_p	YLR460C	YLR460C	hom	Uncharacterized	0.576509554751602	0.28213540674296	no	1374	0.26068201498225	891	NA	FT	OXIDATION-REDUCTION PROCESS			Member of the quinone oxidoreductase family, up-regulated in response to the fungicide mancozeb; possibly up-regulated by iodine	biological_process	molecular_function	cellular_component
YMR251W-A	YMR251W-A	HOR7	hom	Verified	0.576504198460634	0.282137216428562	no	1375	0.264430450610474	911	NA	FT		ENDOPLASMIC RETICULUM|PLASMA MEMBRANE		Protein of unknown function; overexpression suppresses Ca2+ sensitivity of mutants lacking inositol phosphorylceramide mannosyltransferases Csg1p and Csh1p; transcription is induced under hyperosmotic stress and repressed by alpha factor; HOR7 has a paralog, DDR2, that arose from the whole genome duplication	plasma membrane organization	molecular_function	endoplasmic reticulum|plasma membrane
YPR039W_d	YPR039W	YPR039W	hom	Dubious	0.576324163115477	0.282198046727679	no	1376	0.301692040675254	1050	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified non essential genes ERV2/YPR037C and TIP41/YPR040W	Unknown	Unknown	Unknown
YHL039W	YHL039W	EFM1	hom	Verified	0.575839838058709	0.282361721687811	no	1377	0.28459625762215	988	NA					Lysine methyltransferase involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	peptidyl-lysine monomethylation	protein-lysine N-methyltransferase activity	cytoplasm
YPR001W	YPR001W	CIT3	hom	Verified	0.575417225869089	0.282504578427469	no	1378	0.299424957415028	1001	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Dual specificity mitochondrial citrate and methylcitrate synthase; catalyzes the condensation of acetyl-CoA and oxaloacetate to form citrate and that of propionyl-CoA and oxaloacetate to form 2-methylcitrate	propionate catabolic process, 2-methylcitrate cycle|propionate metabolic process|tricarboxylic acid cycle	2-methylcitrate synthase activity|citrate (Si)-synthase activity	mitochondrion
YBR072C-A_p	YBR072C-A	YBR072C-A	hom	Uncharacterized	0.573829591982657	0.283041560887197	no	1379	0.279458165423821	943	NA					Putative protein of unknown function; identified by fungal homology and RT-PCR	biological_process	molecular_function	cellular_component
YEL030W	YEL030W	ECM10	hom	Verified	0.573710676585642	0.28308180113459	no	1380	0.264052078438309	909	NA	FT	PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Heat shock protein of the Hsp70 family; localized in mitochondrial nucleoids, plays a role in protein translocation, interacts with Mge1p in an ATP-dependent manner; overexpression induces extensive mitochondrial DNA aggregations; ECM10 has a paralog, SSC1, that arose from the whole genome duplication	protein refolding|protein targeting to mitochondrion	molecular_function	mitochondrial nucleoid|mitochondrion
YDL242W_d	YDL242W	YDL242W	hom	Dubious	0.573509604883433	0.283149848821722	no	1381	0.261285897811814	868	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YML036W	YML036W	CGI121	hom	Verified	0.573437362419672	0.283174299392544	no	1382	0.303928800425286	1006	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS|CHROMOSOME		Component of the EKC/KEOPS complex with Bud32p, Kae1p, Pcc1p, and Gon7p; EKC/KEOPS complex is required for t6A tRNA modification and may have roles in telomere maintenance and transcription; Cgi121p is dispensable for tRNA modification	telomere maintenance|positive regulation of transcription from RNA polymerase II promoter	molecular_function	EKC/KEOPS complex
YCL021W-A_p	YCL021W-A	YCL021W-A	hom	Uncharacterized	0.573024735397022	0.283313973043436	no	1383	0.263147533093765	900	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YER037W	YER037W	PHM8	hom	Verified	0.572528917057249	0.283481850522618	no	1384	0.27867217228561	965	NA	FT	RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Lysophosphatidic acid (LPA) phosphatase involved in LPA hydrolysis in response to phosphate starvation; phosphatase activity is soluble and Mg2+ dependent; expression is induced by low phosphate levels and by inactivation of Pho85p	cellular response to phosphate starvation	lysophosphatidic acid phosphatase activity	nucleus|cytoplasm
YLR453C	YLR453C	RIF2	hom	Verified	0.572499674741637	0.283491753069475	no	1385	0.276895677679967	973	NA	FT		NUCLEUS|CHROMOSOME		Protein that binds to the Rap1p C-terminus and acts synergistically with Rif1p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation	telomere capping|telomere maintenance via telomerase	telomeric DNA binding	nuclear telomere cap complex
YER118C	YER118C	SHO1	hom	Verified	0.572398254470142	0.283526099068847	no	1386	0.273613011314986	929	NA	FT	SIGNALING	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Transmembrane osmosensor involved in activation of the Cdc42p- and MAP kinase-dependent filamentous growth pathway and the high-osmolarity glycerol response pathway; phosphorylated by Hog1p; interacts with Pbs2p, Msb2p, Hkr1p, and Ste11p	signal transduction involved in filamentous growth|establishment of cell polarity|osmosensory signaling pathway|cellular response to heat|cytokinesis	osmosensor activity|MAP-kinase scaffold activity	integral to membrane|plasma membrane|plasma membrane part|cellular bud|cellular bud neck|mating projection tip
YLR244C	YLR244C	MAP1	hom	Verified	0.571524276735405	0.283822154439814	no	1387	0.296793555031786	985	NA	FT	PROTEOLYSIS		RIBOSOME	Methionine aminopeptidase, catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map2p	negative regulation of gene expression|protein initiator methionine removal involved in protein maturation	metalloaminopeptidase activity|mRNA binding	cytosolic ribosome
YNR025C_d	YNR025C	YNR025C	hom	Dubious	0.571091829761042	0.283968698294334	no	1388	0.283448224180677	984	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion reduces expression of PIS1 gene encoding phosphatidylinositol synthase	Unknown	Unknown	Unknown
YNL157W	YNL157W	IGO1	hom	Verified	0.570726128302201	0.284092652259274	no	1389	0.225823336668272	760	NA	FT		NUCLEUS		Protein required for initiation of G0 program; prevents degradation of nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway; phosphorylated by Rim15p; GFP protein localizes to the cytoplasm and nucleus; similar to Igo2p	mRNA stabilization	molecular_function	nucleus|cytoplasmic mRNA processing body|cytoplasm
YCL069W	YCL069W	VBA3	hom	Verified	0.570037091949939	0.284326270397251	no	1390	0.285543578322529	974	NA					Permease of basic amino acids in the vacuolar membrane	basic amino acid transport|transmembrane transport	basic amino acid transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane
YKL098W	YKL098W	MTC2	hom	Verified	0.569777564646402	0.284414287064446	no	1391	0.32446030253787	1104	NA					Protein of unknown function; mtc2 is synthetically sick with cdc13-1	biological_process	molecular_function	cellular_component
YKL086W	YKL086W	SRX1	hom	Verified	0.569703099473876	0.284439543752065	no	1392	0.278605691786791	951	NA	FT	OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		Sulfiredoxin; contributes to oxidative stress resistance by reducing cysteine-sulfinic acid groups in the peroxiredoxin Tsa1p, which is formed upon exposure to oxidants; conserved in higher eukaryotes; protein abundance increases in response to DNA replication stress	cellular response to oxidative stress	sulfiredoxin activity	nucleus|cytoplasm
YMR055C	YMR055C	BUB2	hom	Verified	0.569321564384192	0.284568967532434	no	1393	0.275146243795926	973	NA	FT	CELL CYCLE|SIGNALING|CELL DIVISION|NUCLEOTIDE METABOLISM	CYTOSKELETON		Mitotic exit network regulator, forms GTPase-activating Bfa1p-Bub2p complex that binds Tem1p and spindle pole bodies, blocks cell cycle progression before anaphase in response to spindle and kinetochore damage	regulation of exit from mitosis|mitotic cell cycle spindle orientation checkpoint	GTPase activator activity	spindle pole body
YHL034C	YHL034C	SBP1	hom	Verified	0.566748650875745	0.285442480989065	no	1394	0.268886415514119	954	NA	FT	TRANSLATION	NUCLEUS		Protein that binds eIF4G and has a role in repression of translation; has an RGG motif; found in cytoplasmic P bodies; found associated with small nucleolar RNAs snR10 and snR11	negative regulation of translation|negative regulation of translation in response to stress	RNA binding|eukaryotic initiation factor 4G binding	nucleolus|cytoplasmic mRNA processing body|cytoplasm
YJR135W-A	YJR135W-A	TIM8	hom	Verified	0.566330091744327	0.285584703983029	no	1395	0.269181478293591	903	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial intermembrane space protein, forms a complex with Tim13p that delivers a subset of hydrophobic proteins to the TIM22 complex for inner membrane insertion; homolog of human TIMM8A, implicated in Mohr-Tranebjaerg syndrome	protein import into mitochondrial inner membrane	protein transporter activity	mitochondrion|integral to membrane|mitochondrial intermembrane space protein transporter complex
YPL055C	YPL055C	LGE1	hom	Verified	0.565829332818196	0.285754902097758	no	1396	0.311626670588752	1056	NA	FT	CHROMATIN ORGANIZATION	NUCLEUS		Protein of unknown function; null mutant forms abnormally large cells, and homozygous diploid null mutant displays delayed premeiotic DNA synthesis and reduced efficiency of meiotic nuclear division	histone methylation|protein monoubiquitination|regulation of cell size|histone ubiquitination|premeiotic DNA replication	molecular_function	nucleus
YDR455C_d	YDR455C	YDR455C	hom	Dubious	0.563357852581452	0.286595615539875	no	1397	0.325118774076398	1118	NA	FF				Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YDR456W	Unknown	Unknown	Unknown
YIL173W	YIL173W	VTH1	hom	Verified	0.563026082011404	0.286708561846549	no	1398	0.262592269952042	875	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	GOLGI APPARATUS		Putative membrane glycoprotein with strong similarity to Vth2p and Pep1p/Vps10p, may be involved in vacuolar protein sorting	Golgi to vacuole transport	signal sequence binding	endosome|integral to membrane
YPL006W	YPL006W	NCR1	hom	Verified	0.560457729882161	0.287583632011462	no	1399	0.275982321930181	968	NA	FT	LIPID METABOLISM			Vacuolar membrane protein that transits through the biosynthetic vacuolar protein sorting pathway, involved in sphingolipid metabolism; glycoprotein and functional orthologue of human Niemann Pick C1 (NPC1) protein	sphingolipid metabolic process	sphingolipid transporter activity	fungal-type vacuole membrane|integral to membrane
YOR036W	YOR036W	PEP12	hom	Verified	0.559759590210975	0.287821715113763	no	1400	0.320803124708587	1089	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	GOLGI APPARATUS		Target membrane receptor (t-SNARE) for vesicular intermediates traveling between the Golgi apparatus and the vacuole; controls entry of biosynthetic, endocytic, and retrograde traffic into the prevacuolar compartment; syntaxin	Golgi to vacuole transport|vacuole inheritance	SNAP receptor activity	endosome|Golgi apparatus
YEL033W_p	YEL033W	MTC7	hom	Uncharacterized	0.55880688043761	0.288146763122108	no	1401	0.332405265613893	1108	NA					Predicted metabolic role based on network analysis derived from ChIP experiments, a large-scale deletion study and localization of transcription factor binding sites; null mutant is sensitive to temperature oscillation in a cdc13-1 mutant	biological_process	molecular_function	cellular_component
YDL088C	YDL088C	ASM4	hom	Verified	0.558796078540384	0.288150449534405	no	1402	0.275193163492344	952	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|CELL DIVISION|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	FG-nucleoporin component of central core of nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport; induces membrane tubulation, which may contribute to nuclear pore assembly; ASM4 has a paralog, NUP53, that arose from the whole genome duplication	nuclear pore organization|mRNA export from nucleus in response to heat stress|mitotic cell cycle spindle assembly checkpoint	nucleocytoplasmic transporter activity|phospholipid binding|single-stranded DNA binding	nuclear pore central transport channel|integral to membrane|nuclear pore
YLR342W-A_p	YLR342W-A	YLR342W-A	hom	Uncharacterized	0.556284652749794	0.28900813854128	no	1403	0.285443280154518	974	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YMR264W	YMR264W	CUE1	hom	Verified	0.555188248788429	0.289382952918113	no	1404	0.308504586596163	1051	NA	FF|FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|PROTEOLYSIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION	UBIQUITIN LIGASE COMPLEX	Ubiquitin-binding protein; endoplasmic reticulum membrane protein that recruits the ubiquitin-conjugating enzyme Ubc7p to the ER where it functions in protein degradation; contains a CUE domain that binds ubiquitin to facilitate intramolecular monoubiquitination; CUE1 has a paralog, CUE4, that arose from the whole genome duplication	ER-associated protein catabolic process|establishment of protein localization to endoplasmic reticulum membrane	ubiquitin-protein ligase activator activity	Doa10p ubiquitin ligase complex|mitochondrion|integral to endoplasmic reticulum membrane
YPR185W	YPR185W	ATG13	hom	Verified	0.554041353834701	0.289775272265317	no	1405	0.280238259400966	933	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|PROTEIN PHOSPHORYLATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS			Regulatory subunit of the Atg1p signaling complex; stimulates Atg1p kinase activity; required for vesicle formation during autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; involved in Atg9p, Atg23p, and Atg27p cycling	piecemeal microautophagy of nucleus|mitochondrion degradation|macroautophagy|activation of protein kinase activity|CVT pathway	protein kinase regulator activity	Atg1p signaling complex|extrinsic to membrane
YJL212C	YJL212C	OPT1	hom	Verified	0.553488292656869	0.289964547522472	no	1406	0.286640472029244	974	NA	FT	PROTEIN LOCALIZATION	PLASMA MEMBRANE		Proton-coupled oligopeptide transporter of the plasma membrane; also transports glutathione and phytochelatin; member of the OPT family	oligopeptide transport|sulfur compound metabolic process	oligopeptide transporter activity|proton-dependent oligopeptide secondary active transmembrane transporter activity	integral to membrane|integral to plasma membrane
YHR135C	YHR135C	YCK1	hom	Verified	0.552728261281123	0.290224749140216	no	1407	0.285689160585682	982	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CELL DIVISION|PROTEIN PHOSPHORYLATION	ENDOPLASMIC RETICULUM|MITOCHONDRION|PLASMA MEMBRANE		Palmitoylated plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck2p in morphogenesis, proper septin assembly, endocytic trafficking; YCK1 has a paralog, YCK2, that arose from the whole genome duplication	cell morphogenesis|endocytosis|protein phosphorylation|cytokinesis|response to glucose stimulus	protein serine/threonine kinase activity|protein kinase activity	mitochondrion|endoplasmic reticulum|plasma membrane
YJR097W	YJR097W	JJJ3	hom	Verified	0.552133710815447	0.290428373527833	no	1408	0.299087095773521	1030	NA	FT		NUCLEUS		Protein of unknown function, contains a CSL Zn finger and a DnaJ-domain; involved in diphthamide biosynthesis; ortholog human Dph4	peptidyl-diphthamide biosynthetic process from peptidyl-histidine	ferrous iron binding	nucleus|cytoplasm
YLR365W_d	YLR365W	YLR365W	hom	Dubious	0.551959030047112	0.290488211712425	no	1409	0.260036046537508	883	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps dubious gene YLR364C-A; YLR365W is not an essential gene	Unknown	Unknown	Unknown
YDL222C	YDL222C	FMP45	hom	Verified	0.551952106639252	0.290490583495692	no	1410	0.263324947134917	898	NA	FT	CELL WALL ORG/BIOGENESIS	MITOCHONDRION|PLASMA MEMBRANE		Integral membrane protein localized to mitochondria (untagged protein); required for sporulation and maintaining sphingolipid content; has sequence similarity to SUR7 and YNL194C	fungal-type cell wall organization|ascospore formation	molecular_function	cell cortex|mitochondrion|integral to membrane|plasma membrane
YJR083C	YJR083C	ACF4	hom	Verified	0.551704760735427	0.2905753238505	no	1411	0.276585133831464	925	NA					Protein of unknown function, computational analysis of large-scale protein-protein interaction data suggests a possible role in actin cytoskeleton organization; potential Cdc28p substrate	biological_process	molecular_function	cellular_component
YPL245W_p	YPL245W	YPL245W	hom	Uncharacterized	0.549674620022568	0.291271283835533	no	1412	0.279894416603564	949	NA	FT		NUCLEUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm	biological_process	molecular_function	nucleus|cytoplasm
YNL279W	YNL279W	PRM1	hom	Verified	0.548349776592786	0.291725877413252	no	1413	0.296162938389237	1026	NA	FT	MEMBRANE ORGANIZATION	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Pheromone-regulated multispanning membrane protein involved in membrane fusion during mating; predicted to have 5 transmembrane segments and a coiled coil domain; localizes to the shmoo tip; regulated by Ste12p	plasma membrane fusion involved in cytogamy|response to pheromone	molecular_function	integral to membrane|mating projection tip
YER182W_p	YER182W	FMP10	hom	Uncharacterized	0.547864228529552	0.291892566295944	no	1414	0.288349897489526	987	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YGL039W	YGL039W	YGL039W	hom	Verified	0.547019103303484	0.292182803945922	no	1415	0.26891263438601	895	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS			Oxidoreductase shown to reduce carbonyl compounds to chiral alcohols	cellular ketone metabolic process|cellular aromatic compound metabolic process	oxidoreductase activity, acting on CH-OH group of donors|carbonyl reductase (NADPH) activity	cytoplasm
YLR042C_p	YLR042C	YLR042C	hom	Uncharacterized	0.546577380475154	0.292334556293913	no	1416	0.275827011607718	938	NA					Protein of unknown function; localizes to the cytoplasm; YLL042C is not an essential gene	biological_process	molecular_function	fungal-type cell wall
YMR130W_p	YMR130W	YMR130W	hom	Uncharacterized	0.546511723791465	0.292357115548764	no	1417	0.254368647211975	874	NA					Putative protein of unknown function; YMR130W is not an essential gene	biological_process	molecular_function	cellular_component
YBR019C	YBR019C	GAL10	hom	Verified	0.546127570360022	0.292489124656463	no	1418	0.286396570467206	980	NA	FT	CARBOHYDRATE METABOLISM			UDP-glucose-4-epimerase, catalyzes the interconversion of UDP-galactose and UDP-D-glucose in galactose metabolism; also catalyzes the conversion of alpha-D-glucose or alpha-D-galactose to their beta-anomers	galactose catabolic process via UDP-galactose	aldose 1-epimerase activity|UDP-glucose 4-epimerase activity	cytosol
YJL020C	YJL020C	BBC1	hom	Verified	0.545428344669931	0.292729475145452	no	1419	0.269239708394403	926	NA	FT	CYTOSKELETON ORGANIZATION	CYTOSKELETON		Protein possibly involved in assembly of actin patches; interacts with an actin assembly factor Las17p and with the SH3 domains of Type I myosins Myo3p and Myo5p; localized predominantly to cortical actin patches	actin cytoskeleton organization	myosin I binding	actin cortical patch
YLR081W	YLR081W	GAL2	hom	Verified	0.544139578011201	0.293172713467043	no	1420	0.273851320788936	930	NA	FT	CARBOHYDRATE METABOLISM	PLASMA MEMBRANE		Galactose permease, required for utilization of galactose; also able to transport glucose	galactose transport|galactose metabolic process	galactose transmembrane transporter activity|glucose transmembrane transporter activity	integral to membrane|plasma membrane
YLR213C	YLR213C	CRR1	hom	Verified	0.543596677356759	0.293359523369305	no	1421	0.285979932047243	979	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM			Putative glycoside hydrolase of the spore wall envelope; required for normal spore wall assembly, possibly for cross-linking between the glucan and chitosan layers; expressed during sporulation	ascospore wall assembly	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	ascospore wall
YJR059W	YJR059W	PTK2	hom	Verified	0.54107838008668	0.29422677966777	no	1422	0.328055895775461	1115	NA	FF|FT	CELL CYCLE|ION HOMEOSTASIS|PROTEIN PHOSPHORYLATION|ION HOMEOSTASIS	NUCLEUS|PLASMA MEMBRANE		Putative serine/threonine protein kinase involved in regulation of ion transport across plasma membrane; enhances spermine uptake	protein phosphorylation|cellular ion homeostasis|polyamine transport|G1/S transition of mitotic cell cycle|regulation of cell size	protein kinase activity	nucleus|plasma membrane|cytoplasm
YPR011C_p	YPR011C	YPR011C	hom	Uncharacterized	0.540883001778221	0.294294113925289	no	1423	0.263997913683763	894	NA	FT		MITOCHONDRION		Putative transporter, member of the mitochondrial carrier family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	transport	transporter activity	mitochondrion|integral to membrane|mitochondrial inner membrane
YLR169W_d	YLR169W	YLR169W	hom	Dubious	0.540425804826124	0.294451707929787	no	1424	0.27316138660048	928	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDR461W	YDR461W	MFA1	hom	Verified	0.540069293521545	0.294574623009132	no	1425	0.299289930557668	1009	NA	FT	SIGNALING	PLASMA MEMBRANE		Mating pheromone a-factor, made by a cells; interacts with alpha cells to induce cell cycle arrest and other responses leading to mating; biogenesis involves C-terminal modification, N-terminal proteolysis, and export; also encoded by MFA2	pheromone-dependent signal transduction involved in conjugation with cellular fusion	mating pheromone activity	extracellular region
YKR059W	YKR059W	TIF1	hom	Verified	0.538120464123733	0.29524694264284	no	1426	0.294662453063389	995	NA	FT	TRANSLATION		RIBOSOME	Translation initiation factor eIF4A; DEA(D/H)-box RNA helicase that couples ATPase activity to RNA binding and unwinding; forms a dumbbell structure of two compact domains connected by a linker; interacts with eIF4G; protein abundance increases in response to DNA replication stress; TIF1 has a paralog, TIF2, that arose from the whole genome duplication	translational initiation	ATP-dependent RNA helicase activity|translation initiation factor activity	ribosome|eukaryotic translation initiation factor 4F complex
YGL041C-B_p	YGL041C-B	YGL041C-B	hom	Uncharacterized	0.537591025826802	0.295429713584648	no	1427	0.28259930089667	969	NA					Putative protein of unknown function; identified by fungal homology and RT-PCR	biological_process	molecular_function	cellular_component
YJL092W	YJL092W	SRS2	hom	Verified	0.536953496549682	0.29564986838003	no	1428	0.303434951080484	1027	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		DNA helicase and DNA-dependent ATPase involved in DNA repair and checkpoint recovery, needed for proper timing of commitment to meiotic recombination and transition from Meiosis I to II; blocks trinucleotide repeat expansion; affects genome stability	DNA repair|double-strand break repair via nonhomologous end joining|DNA duplex unwinding	DNA helicase activity	nucleus
YNL329C	YNL329C	PEX6	hom	Verified	0.536457446178925	0.295821219117726	no	1429	0.301745824351631	1038	NA	FT	PROTEIN LOCALIZATION|SIGNALING|PEROXISOME ORGANIZATION			AAA-peroxin that heterodimerizes with AAA-peroxin Pex1p and participates in the recycling of peroxisomal signal receptor Pex5p from the peroxisomal membrane to the cystosol	protein import into peroxisome matrix, receptor recycling|replicative cell aging	ATPase activity|protein heterodimerization activity	cytosol|peroxisome
YDL224C	YDL224C	WHI4	hom	Verified	0.535612228503961	0.296113287794735	no	1430	0.253362018275617	857	NA					Putative RNA binding protein; regulates the cell size requirement for passage through Start and commitment to cell division; WHI4 has a paralog, WHI3, that arose from the whole genome duplication	regulation of cell size	RNA binding	cytoplasm
YNL159C	YNL159C	ASI2	hom	Verified	0.534383727174713	0.296538037589658	no	1431	0.262135571815189	927	NA	FT	PROTEOLYSIS	ENDOMEMBRANE SYSTEM|NUCLEUS		Integral inner nuclear membrane protein that acts with Asi1p and Asi3p to ensure the fidelity of SPS-sensor signalling by maintaining the dormant repressed state of gene expression in the absence of inducing signals	ubiquitin-dependent protein catabolic process	molecular_function	nuclear inner membrane
YMR245W_d	YMR245W	YMR245W	hom	Dubious	0.532955851486883	0.297032070813559	no	1432	0.353096565679543	1184	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YGR174W-A_p	YGR174W-A	YGR174W-A	hom	Uncharacterized	0.532888493932993	0.297055385267309	no	1433	0.276573359333312	952	NA					Putative protein of unknown function; predicted to have a role in cell budding based on computational guilt by association analysis	biological_process	molecular_function	cellular_component
YAL060W	YAL060W	BDH1	hom	Verified	0.531752742750695	0.297448628508032	no	1434	0.303874875185575	1032	NA	FT	OXIDATION-REDUCTION PROCESS			NAD-dependent (R,R)-butanediol dehydrogenase, catalyzes oxidation of (R,R)-2,3-butanediol to (3R)-acetoin, oxidation of meso-butanediol to (3S)-acetoin, and reduction of acetoin; enhances use of 2,3-butanediol as an aerobic carbon source	alcohol metabolic process|butanediol biosynthetic process	(R,R)-butanediol dehydrogenase activity	cytoplasm
YOR049C	YOR049C	RSB1	hom	Verified	0.530340414867626	0.297937965195798	no	1435	0.295186491491483	981	NA	FT	MEMBRANE ORGANIZATION	ENDOPLASMIC RETICULUM|PLASMA MEMBRANE		Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane	phospholipid translocation|fatty acid transport	phospholipid-translocating ATPase activity	integral to membrane|endoplasmic reticulum|plasma membrane
YGR184C	YGR184C	UBR1	hom	Verified	0.530008540180461	0.298053004796676	no	1436	0.311312774485157	1025	NA	FT	PROTEOLYSIS			E3 ubiquitin ligase (N-recognin); forms heterodimer with Rad6p to ubiquitinate substrates in the N-end rule pathway; regulates peptide transport via Cup9p ubiquitination; plays a major role in targeting cytosolic misfolded proteins for degradation; mutation in human UBR1 causes Johansson-Blizzard Syndrome (JBS)	regulation of dipeptide transport|ubiquitin-dependent protein catabolic process via the N-end rule pathway|cytoplasm-associated proteasomal ubiquitin-dependent protein catabolic process|protein polyubiquitination	ubiquitin-protein ligase activity	proteasome regulatory particle, base subcomplex|cytoplasm
YNL101W	YNL101W	AVT4	hom	Verified	0.529875167687406	0.298099242159724	no	1437	0.28817660776011	976	NA	FT	VACUOLAR TRANSPORT			Vacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters	amino acid export from vacuole	transporter activity|L-glutamine transmembrane transporter activity|L-isoleucine transmembrane transporter activity|L-tyrosine transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane|fungal-type vacuole
YDL176W	YDL176W	YDL176W	hom	Verified	0.52950882131549	0.298226263348777	no	1438	0.273397533820233	918	NA					Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene	biological_process	molecular_function	cellular_component
YNL074C	YNL074C	MLF3	hom	Verified	0.529462620379886	0.298242284085872	no	1439	0.288474289961672	994	NA					Serine-rich protein of unknown function, predicted to be palmitoylated; overproduction suppresses the growth inhibition caused by exposure to the immunosuppressant leflunomide	response to drug	molecular_function	cytoplasm
YNL205C_d	YNL205C	YNL205C	hom	Dubious	0.529150658451415	0.298350470939768	no	1440	0.302220802260982	1032	NA					Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YOR006C	YOR006C	TSR3	hom	Verified	0.528602715947667	0.298540537921208	no	1441	0.326674348950129	1100	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Protein required for 20S pre-rRNA processing; involved in processing of the 20S pre-rRNA at site D to generate mature 18S rRNA; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; relative distribution to the nucleus increases upon DNA replication stress	maturation of SSU-rRNA	molecular_function	nucleus|cytoplasm
YPL179W	YPL179W	PPQ1	hom	Verified	0.527950055180878	0.298767000785962	no	1442	0.302041492052857	1005	NA	FT	TRANSLATION			Putative protein serine/threonine phosphatase; null mutation enhances efficiency of translational suppressors	protein dephosphorylation|regulation of translation	protein serine/threonine phosphatase activity	cytoplasm
YBR085C-A	YBR085C-A	YBR085C-A	hom	Verified	0.527888086692813	0.298788506919876	no	1443	0.281678793300222	989	NA	FT		NUCLEUS		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	nucleus|cytoplasm
YPL017C	YPL017C	IRC15	hom	Verified	0.52740082266597	0.29895763617573	no	1444	0.325554714124154	1097	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|OXIDATION-REDUCTION PROCESS|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION	CYTOSKELETON		Microtubule associated protein; regulates microtubule dynamics; required for accurate meiotic chromosome segregation; null mutant displays large budded cells due to delayed mitotic progression, increased levels of spontaneous Rad52 foci	microtubule nucleation|mitotic recombination|microtubule anchoring|meiotic sister chromatid segregation|attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation|positive regulation of mitotic cell cycle	microtubule binding|S-adenosylmethionine-dependent methyltransferase activity	microtubule|cytoplasm
YHL020C	YHL020C	OPI1	hom	Verified	0.527388317469974	0.298961977299241	no	1445	0.313883604413505	1087	NA	FT	TRANSCRIPTION FROM RNA POL II|LIPID METABOLISM|SIGNALING	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM		Transcriptional regulator of a variety of genes; phosphorylation by protein kinase A stimulates Opi1p function in negative regulation of phospholipid biosynthetic genes; involved in telomere maintenance	endoplasmic reticulum unfolded protein response|negative regulation of transcription from RNA polymerase II promoter|phospholipid biosynthetic process|positive regulation of transcription from RNA polymerase II promoter	transcription corepressor activity	nuclear membrane|nucleoplasm|nuclear envelope|endoplasmic reticulum|nucleus
YBR008C	YBR008C	FLR1	hom	Verified	0.527168936662408	0.299038139033171	no	1446	0.281340588204309	956	NA	FT		PLASMA MEMBRANE		Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; involved in efflux of fluconazole, diazaborine, benomyl, methotrexate, and other drugs; expression induced in cells treated with the mycotoxin patulin; relocalizes from nucleus to plasma membrane upon DNA replication stress	drug transmembrane transport|transmembrane transport	fluconazole transporter activity|drug transmembrane transporter activity	integral to membrane|plasma membrane
YPL095C	YPL095C	EEB1	hom	Verified	0.52528057876873	0.299694078168163	no	1447	0.313624465232851	1077	NA	FT	KETONE METABOLISM|LIPID METABOLISM			Acyl-coenzymeA:ethanol O-acyltransferase; responsible for the major part of medium-chain fatty acid ethyl ester biosynthesis during fermentation; possesses short-chain esterase activity; may be involved in lipid metabolism and detoxification; EEB1 has a paralog, EHT1, that arose from the whole genome duplication	medium-chain fatty acid catabolic process|medium-chain fatty acid biosynthetic process	short-chain carboxylesterase activity|alcohol O-octanoyltransferase activity	cellular_component
YBR200W-A_p	YBR200W-A	YBR200W-A	hom	Uncharacterized	0.524692945595075	0.299898331042244	no	1448	0.31554416821875	1075	NA					Putative protein of unknown function; identified by fungal homology and RT-PCR	biological_process	molecular_function	cellular_component
YDL002C	YDL002C	NHP10	hom	Verified	0.523094479956012	0.300454253350393	no	1449	0.310637037393022	1064	NA	FT	CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Protein related to mammalian high mobility group proteins; preferentially binds DNA ends, protecting them from exonucleatic cleavage; likely component of the chromatin-remodeling complex INO80 complex; proposed to be involved in DNA repair	double-strand break repair|nucleosome mobilization	DNA end binding|loop DNA binding	nucleus|Ino80 complex
YDR074W	YDR074W	TPS2	hom	Verified	0.522702298771399	0.300590719150967	no	1450	0.395879341559068	1313	NA	FT	CARBOHYDRATE METABOLISM	MITOCHONDRION		Phosphatase subunit of the trehalose-6-P synthase/phosphatase complex; involved in synthesis of the storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway; protein abundance increases in response to DNA replication stress	trehalose biosynthetic process|response to stress	trehalose-phosphatase activity	mitochondrion|alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)
YPR189W	YPR189W	SKI3	hom	Verified	0.522642988734883	0.300611359475458	no	1451	0.278423425951982	963	NA	FT		NUCLEUS		Ski complex component and TPR protein, mediates 3'-5' RNA degradation by the cytoplasmic exosome; null mutants have superkiller phenotype of increased viral dsRNAs and are synthetic lethal with mutations in 5'-3' mRNA decay	nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'|nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay|nuclear-transcribed mRNA catabolic process, non-stop decay	molecular_function	Ski complex
YMR276W	YMR276W	DSK2	hom	Verified	0.521300560661532	0.301078705246916	no	1452	0.269526104143979	921	NA	FT	CELL CYCLE|PROTEOLYSIS|CYTOSKELETON ORGANIZATION	NUCLEUS		Nuclear-enriched ubiquitin-like polyubiquitin-binding protein; required for spindle pole body (SPB) duplication and for transit through the G2/M phase of the cell cycle; involved in proteolysis; interacts with the proteasome; protein abundance increases in response to DNA replication stress	ER-associated protein catabolic process|spindle pole body duplication associated with nuclear envelope	protein binding, bridging	nucleus
YCL026C-A	YCL026C-A	FRM2	hom	Verified	0.521120998892645	0.301141241747301	no	1453	0.277004099875941	962	NA	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS	NUCLEUS		Type II nitroreductase, using NADH as reductant; mutants are defective in fatty acid mediated repression of genes involved in fatty acid biosynthesis indicative of a role in lipid signaling; involved in the oxidative stress response; transcription induction by cadmium and selenite indicates a possible role in the metal stress response; expression induced in cells treated with the mycotoxin patulin	cellular response to oxidative stress|negative regulation of fatty acid metabolic process	oxidoreductase activity, acting on NADH or NADPH, nitrogenous group as acceptor	nucleus|cytoplasm
YPR150W_d	YPR150W	YPR150W	hom	Dubious	0.521059211117245	0.301162762109237	no	1454	0.272544342439045	932	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene SUE1/YPR151C	Unknown	Unknown	Unknown
YLR006C	YLR006C	SSK1	hom	Verified	0.52104573201095	0.301167456904163	no	1455	0.281548071437109	958	NA	FT	SIGNALING|PROTEIN PHOSPHORYLATION			Cytoplasmic response regulator; part of a two-component signal transducer that mediates osmosensing via a phosphorelay mechanism; required for mitophagy; dephosphorylated form is degraded by the ubiquitin-proteasome system; potential Cdc28p substrate	activation of MAPKKK activity involved in osmosensory signaling pathway|positive regulation of protein autophosphorylation|osmosensory signaling pathway via two-component system	protein kinase activator activity|two-component response regulator activity|protein homodimerization activity|mitogen-activated protein kinase kinase kinase binding	cytoplasm
YBR162W-A	YBR162W-A	YSY6	hom	Verified	0.520407530490566	0.301389781273436	no	1456	0.285167827728584	955	NA	FT	PROTEIN LOCALIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein whose expression suppresses a secretory pathway mutation in E. coli; has similarity to the mammalian RAMP4 protein involved in secretion	protein secretion	molecular_function	endoplasmic reticulum
YMR224C	YMR224C	MRE11	hom	Verified	0.518281633596666	0.302130892703435	no	1457	0.311840560160042	1043	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS|MITOCHONDRION		Subunit of the MRX complex with Rad50p and Xrs2p; complex functions in repair of DNA double-strand breaks and in telomere stability; exhibits nuclease activity that appears to be required for MRX function; widely conserved; forms nuclear foci upon DNA replication stress	DNA repair|meiotic DNA double-strand break formation|double-strand break repair via nonhomologous end joining|base-excision repair|ascospore formation|meiotic DNA double-strand break processing|double-strand break repair via break-induced replication|regulation of transcription during meiosis	3'-5' exonuclease activity|protein complex scaffold|double-stranded telomeric DNA binding|adenylate kinase activity|telomeric DNA binding|single-stranded telomeric DNA binding|endodeoxyribonuclease activity|G-quadruplex DNA binding|endonuclease activity	mitochondrion|nucleus|Mre11 complex
YNR056C	YNR056C	BIO5	hom	Verified	0.5180861216906	0.302199091401743	no	1458	0.293696183542691	999	NA	FT	KETONE METABOLISM|COFACTOR METABOLISM	PLASMA MEMBRANE		Putative transmembrane protein involved in the biotin biosynthesis pathway; responsible for uptake of 7-keto 8-aminopelargonic acid; BIO5 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis	biotin biosynthetic process|vitamin transport	transmembrane transporter activity	integral to membrane|plasma membrane
YLR180W	YLR180W	SAM1	hom	Verified	0.516725942905141	0.302673741709731	no	1459	0.289694211622259	954	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM			S-adenosylmethionine synthetase; catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; SAM1 has a paralog, SAM2, that arose from the whole genome duplication	methionine metabolic process|S-adenosylmethionine biosynthetic process	methionine adenosyltransferase activity	cytoplasm
YGL224C	YGL224C	SDT1	hom	Verified	0.516521126314185	0.302745243781686	no	1460	0.300940413497636	994	NA					Pyrimidine nucleotidase; overexpression suppresses the 6-AU sensitivity of transcription elongation factor S-II, as well as resistance to other pyrimidine derivatives	pyrimidine nucleobase metabolic process	nucleotidase activity	cellular_component
YDR316W	YDR316W	OMS1	hom	Verified	0.51608149069548	0.30289874740706	no	1461	0.324292544434821	1085	NA	FT		MITOCHONDRION		Protein integral to the mitochondrial membrane; has a conserved methyltransferase motif; multicopy suppressor of respiratory defects caused by OXA1 mutations	biological_process	S-adenosylmethionine-dependent methyltransferase activity	mitochondrial envelope|mitochondrion
YBR215W	YBR215W	HPC2	hom	Verified	0.516055083044124	0.302907969038988	no	1462	0.302255508566097	1043	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION	NUCLEUS		Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; mutants display synthetic defects with subunits of FACT, a complex that allows passage of RNA Pol II through nucleosomes	DNA replication-independent nucleosome assembly|regulation of transcription involved in G1/S phase of mitotic cell cycle|transcription elongation from RNA polymerase II promoter	nucleosome binding|DNA binding	HIR complex|nucleus
YJR104C	YJR104C	SOD1	hom	Verified	0.515052121230504	0.303258299328131	no	1463	0.388099351381207	1307	NA	FF|FT	ION HOMEOSTASIS|CELL WALL ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|RESPONSE TO OXIDATIVE STRESS	NUCLEUS|MITOCHONDRION		Cytosolic copper-zinc superoxide dismutase; some mutations are analogous to those that cause ALS (amyotrophic lateral sclerosis) in humans; protein abundance increases in response to DNA replication stress and in response to prolonged exposure to boric acid	cellular copper ion homeostasis|fungal-type cell wall organization|superoxide metabolic process|cellular zinc ion homeostasis|positive regulation of sequence-specific DNA binding transcription factor activity|age-dependent response to reactive oxygen species involved in chronological cell aging	superoxide dismutase activity	cytosol|mitochondrion|nucleus|mitochondrial intermembrane space
YML061C	YML061C	PIF1	hom	Verified	0.51419708020668	0.303557104467587	no	1464	0.325418524157633	1080	NA	FT	RESPONSE TO DNA DAMAGE|MITOCHONDRION ORGANIZATION	NUCLEUS|MITOCHONDRION		DNA helicase; exists in a nuclear form that acts as a catalytic inhibitor of telomerase; and as a mitochondrial form involved in repair and recombination of mitochondrial DNA; mutations affect zinc and iron homeostasis; regulated by Rad53p-dependent phosphorylation in rho0 cells	chromosome organization|negative regulation of telomere maintenance via telomerase|telomere maintenance|mitochondrial genome maintenance|DNA recombination	DNA helicase activity|telomerase inhibitor activity	mitochondrion|nucleus|mitochondrial membrane
YGR176W_d	YGR176W	YGR176W	hom	Dubious	0.514043491285324	0.303610792027918	no	1465	0.287853303506343	973	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YLL055W	YLL055W	YCT1	hom	Verified	0.513070256776505	0.303951088146548	no	1466	0.276907450055873	924	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|PLASMA MEMBRANE		High-affinity cysteine-specific transporter with similarity to the Dal5p family of transporters; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YCT1 is not an essential gene	cysteine transport	ion transmembrane transporter activity|cysteine transmembrane transporter activity	integral to membrane|endoplasmic reticulum
YLR214W	YLR214W	FRE1	hom	Verified	0.512859530745839	0.304024791907705	no	1467	0.278664006162588	950	NA	FT	ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|GEN. OF PRECURSOR METABOLITES AND ENERGY	PLASMA MEMBRANE		Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low copper and iron levels	iron ion transport|copper ion import	ferric-chelate reductase activity	integral to membrane|plasma membrane
YDR405W	YDR405W	MRP20	hom	Verified	0.512805581710331	0.304043662460717	no	1468	0.289070794574087	1001	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YIL095W	YIL095W	PRK1	hom	Verified	0.512755247884205	0.304061268939175	no	1469	0.295519120651943	993	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Protein serine/threonine kinase; regulates the organization and function of the actin cytoskeleton and reduces endocytic ability of cell through the phosphorylation of the Pan1p-Sla1p-End3p protein complex; PRK1 has a paralog, ARK1, that arose from the whole genome duplication	regulation of endocytosis|actin filament organization|protein phosphorylation|actin cortical patch assembly|cytokinesis	protein serine/threonine kinase activity|protein kinase activity	mating projection tip|actin cortical patch
YMR062C	YMR062C	ARG7	hom	Verified	0.510097811828284	0.304991469063062	no	1470	0.3515995037714	1183	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|CELL WALL ORG/BIOGENESIS	MITOCHONDRION		Mitochondrial ornithine acetyltransferase, catalyzes the fifth step in arginine biosynthesis; also possesses acetylglutamate synthase activity, regenerates acetylglutamate while forming ornithine	fungal-type cell wall organization|ornithine biosynthetic process|arginine biosynthetic process	acetyl-CoA:L-glutamate N-acetyltransferase activity|glutamate N-acetyltransferase activity	mitochondrion|mitochondrial matrix
YKL007W	YKL007W	CAP1	hom	Verified	0.509986221434699	0.305030557434001	no	1471	0.304360797517254	1006	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Alpha subunit of the capping protein heterodimer (Cap1p and Cap2p); capping protein (CP) binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches; protein increases in abundance and relocalizes from bud neck to plasma membrane upon DNA replication stress	barbed-end actin filament capping	actin filament binding	actin filament|F-actin capping protein complex|mating projection tip|actin cortical patch
YNL219C	YNL219C	ALG9	hom	Verified	0.508656054794443	0.305496665220148	no	1472	0.317322665612016	1053	NA	FT	LIPID METABOLISM|CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Mannosyltransferase, involved in N-linked glycosylation; catalyzes both the transfer of seventh mannose residue on B-arm and ninth mannose residue on the C-arm from Dol-P-Man to lipid-linked oligosaccharides; mutation of the human ortholog causes type 1 congenital disorders of glycosylation	dolichol-linked oligosaccharide biosynthetic process|protein glycosylation	mannosyltransferase activity	integral to membrane|endoplasmic reticulum
YKR070W_p	YKR070W	YKR070W	hom	Uncharacterized	0.508370779229606	0.305596670614088	no	1473	0.297465917038558	980	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YDR158W	YDR158W	HOM2	hom	Verified	0.508275336168366	0.305630132101678	no	1474	0.335386701141126	1155	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS	NUCLEUS		Aspartic beta semi-aldehyde dehydrogenase, catalyzes the second step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis	methionine biosynthetic process|threonine biosynthetic process|homoserine biosynthetic process	aspartate-semialdehyde dehydrogenase activity	nucleus|plasma membrane|cytoplasm
YKL126W	YKL126W	YPK1	hom	Verified	0.507137791188021	0.306029070152038	no	1475	0.429348090834291	1435	NA	FF|FT	VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS|PROTEIN PHOSPHORYLATION	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Serine/threonine protein kinase; phosphorylates and downregulates flippase activator Fpk1p; inactivates Orm1p and Orm2p (inhibitors of serine:palmitoyl-coenzyme A transferase) by phosphorylation in response to compromised sphingolipid synthesis; mutations affect receptor-mediated endocytosis and sphingolipid-mediated and cell integrity signaling pathways; homolog of mammalian kinase SGK; YPK1 has a paralog, YPK2, that arose from the whole genome duplication	eisosome assembly|protein autophosphorylation|negative regulation of phospholipid translocation|protein phosphorylation	protein serine/threonine kinase activity	cytosol|plasma membrane|cellular bud neck
YHR044C	YHR044C	DOG1	hom	Verified	0.506798674790402	0.306148043139694	no	1476	0.291153870246727	996	NA	FT	CARBOHYDRATE METABOLISM			2-deoxyglucose-6-phosphate phosphatase; paralogous to DOG2; member of a family of low molecular weight phosphatases; confers 2-deoxyglucose resistance when overexpressed, in vivo substrate has not yet been identified	glucose metabolic process	2-deoxyglucose-6-phosphatase activity	cellular_component
YGL250W	YGL250W	RMR1	hom	Verified	0.506766243319753	0.306159422218809	no	1477	0.297787394633403	1026	NA	FT	CELL CYCLE	NUCLEUS		Protein required for meiotic recombination and gene conversion; null mutant displays reduced PIS1 expression and growth defects on non-fermentable carbon sources and minimal media; GFP-fusion protein localizes to both cytoplasm and nucleus	meiotic gene conversion|reciprocal meiotic recombination	molecular_function	nucleus|cytoplasm
YNL067W	YNL067W	RPL9B	hom	Verified	0.506414137877636	0.306282975851495	no	1478	0.255797490278337	859	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L9B; nearly identical to paralog Rpl9Ap; homologous to mammalian ribosomal protein L9 and bacterial L6	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YFR030W	YFR030W	MET10	hom	Verified	0.505294814927796	0.306675892038587	no	1479	0.305703858436988	1039	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY			Subunit alpha of assimilatory sulfite reductase, which converts sulfite into sulfide	sulfate assimilation	sulfite reductase (NADPH) activity	sulfite reductase complex (NADPH)
YOL075C_p	YOL075C	YOL075C	hom	Uncharacterized	0.504844056812299	0.306834184565805	no	1480	0.273722005375104	913	NA	FT	NUCLEOTIDE METABOLISM			Putative ABC transporter	transport	ATPase activity, coupled to transmembrane movement of substances	integral to membrane|membrane
YNL087W	YNL087W	TCB2	hom	Verified	0.504342349105385	0.307010411401031	no	1481	0.307493525211755	1043	NA	FT		ENDOPLASMIC RETICULUM|PLASMA MEMBRANE		ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; contains 3 calcium and lipid binding domains; mRNA is targeted to the bud	biological_process	lipid binding	cellular bud|cortical endoplasmic reticulum
YPR078C_p	YPR078C	YPR078C	hom	Uncharacterized	0.504242792201154	0.307045386465037	no	1482	0.295289263444956	1001	NA					Putative protein of unknown function; possible role in DNA metabolism and/or in genome stability; expression is heat-inducible	biological_process	molecular_function	cellular_component
YGR023W	YGR023W	MTL1	hom	Verified	0.503952086141107	0.307147523664662	no	1483	0.301982893608135	1000	NA	FT	CELL WALL ORG/BIOGENESIS|RESPONSE TO NUTRIENT LEVELS|RESPONSE TO OXIDATIVE STRESS	PLASMA MEMBRANE		Putative plasma membrane sensor, involved in cell integrity signaling and stress response during glucose starvation and oxidative stress; has structural and functional similarity to Mid2p	cellular response to glucose starvation|fungal-type cell wall organization|cellular response to oxidative stress	molecular_function	integral to plasma membrane
YOR220W	YOR220W	RCN2	hom	Verified	0.503888109492687	0.307170003346741	no	1484	0.300591277756191	1060	NA					Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; phosphorylated in response to alpha factor; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	cytoplasm
YER169W	YER169W	RPH1	hom	Verified	0.502195479516657	0.307765011227986	no	1485	0.318314142224351	1106	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION	NUCLEUS		JmjC domain-containing histone demethylase; specifically demethylates H3K36 tri- and dimethyl modification states; associates with actively transcribed (RNA polymerase II) regions in vivo and specifically targets H3K36 in its trimethylation state as its substrate; transcriptional repressor of PHR1; Rph1p phosphorylation during DNA damage is under control of the MEC1-RAD53 pathway; RPH1 has a paralog, GIS1, that arose from the whole genome duplication	negative regulation of transcription from RNA polymerase II promoter|histone demethylation	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|sequence-specific DNA binding|histone demethylase activity (H3-K36 specific)|histone demethylase activity (H3-K9 specific)	nucleus
YPL212C	YPL212C	PUS1	hom	Verified	0.498761510141836	0.308973702983425	no	1486	0.294456782927772	1012	NA	FT	RNA PROCESSING	NUCLEUS		tRNA:pseudouridine synthase, introduces pseudouridines at positions 26-28, 34-36, 65, and 67 of tRNA; nuclear protein that appears to be involved in tRNA export; also acts on U2 snRNA	snRNA pseudouridine synthesis|tRNA pseudouridine synthesis	pseudouridine synthase activity	nucleus
YPL036W	YPL036W	PMA2	hom	Verified	0.497277354362668	0.309496739410057	no	1487	0.287349612469692	957	NA	FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS	MITOCHONDRION|PLASMA MEMBRANE		Plasma membrane H+-ATPase, isoform of Pma1p, involved in pumping protons out of the cell; regulator of cytoplasmic pH and plasma membrane potential	proton transport|regulation of pH	hydrogen-exporting ATPase activity, phosphorylative mechanism	mitochondrion|integral to membrane|plasma membrane
YDR078C	YDR078C	SHU2	hom	Verified	0.496544663951215	0.309755091780221	no	1488	0.312812427104929	1069	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function	recombinational repair|maintenance of rDNA|error-free translesion synthesis	molecular_function	Shu complex
YBR279W	YBR279W	PAF1	hom	Verified	0.49532813086772	0.310184258437782	no	1489	0.395094147882306	1322	NA	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|RIBOSOME BIOGENESIS|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION|GENE SILENCING	NUCLEUS|CHROMOSOME	RNA POL II, HOLOENZYME	Component of the Paf1p complex involved in transcription elongation; binds to and modulates the activity of RNA polymerases I and II; required for expression of a subset of genes, including cell cycle-regulated genes; involved in SER3 repression by helping to maintain SRG1 transcription-dependent nucleosome occupancy; homolog of human PD2/hPAF1	negative regulation of DNA recombination|mRNA 3'-end processing|snoRNA transcription from an RNA polymerase II promoter|regulation of transcription by chromatin organization|transcription from RNA polymerase I promoter|regulation of transcription-coupled nucleotide-excision repair|rRNA processing|transcription elongation from RNA polymerase I promoter|regulation of chromatin silencing at telomere|regulation of transcription from RNA polymerase II promoter|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of histone H3-K4 methylation|negative regulation of transcription from RNA polymerase II promoter|global genome nucleotide-excision repair|chromatin silencing at rDNA|Unknown|snoRNA 3'-end processing|transcription elongation from RNA polymerase II promoter|regulation of transcription involved in G1 phase of mitotic cell cycle	RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity|chromatin binding|TFIIF-class binding transcription factor activity|RNA polymerase II core binding|RNA polymerase II transcription factor binding transcription factor activity	transcriptionally active chromatin|nucleus|Cdc73/Paf1 complex
YGR204C-A_p	YGR204C-A	YGR204C-A	hom	Uncharacterized	0.495265282965615	0.310206436854761	no	1490	0.299695142189703	997	NA					Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching	biological_process	molecular_function	cellular_component
YCR020C	YCR020C	PET18	hom	Verified	0.495254900374128	0.310210100837353	no	1491	0.318654164888147	1077	NA					Protein of unknown function, has weak similarity to proteins involved in thiamin metabolism; expression is induced in the absence of thiamin	thiamine metabolic process	molecular_function	cytosol
YCR031C	YCR031C	RPS14A	hom	Verified	0.493972068535216	0.310662952878826	no	1492	0.309165102515653	1017	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION	NUCLEUS	RIBOSOME	Protein component of the small (40S) ribosomal subunit; required for ribosome assembly and 20S pre-rRNA processing; mutations confer cryptopleurine resistance; homologous to mammalian ribosomal protein S14 and bacterial S11; RPS14A has a paralog, RPS14B, that arose from the whole genome duplication	cytoplasmic translation|ribosomal small subunit assembly|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome|mRNA binding	small-subunit processome|cytosolic small ribosomal subunit|90S preribosome
YKL169C_d	YKL169C	YKL169C	hom	Dubious	0.492500105812537	0.311182923573887	no	1493	0.335145245593448	1133	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene MRPL38	Unknown	Unknown	Unknown
YPL216W_p	YPL216W	YPL216W	hom	Uncharacterized	0.492267301606941	0.311265196195794	no	1494	0.31260162660731	1062	NA	FT	CHROMATIN ORGANIZATION	NUCLEUS		Putative protein of unknown function; YPL216W is not an essential gene	biological_process	molecular_function	cellular_component
YJR024C	YJR024C	MDE1	hom	Verified	0.49199906329675	0.311360002862663	no	1495	0.299232283657499	990	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			5'-methylthioribulose-1-phosphate dehydratase; acts in the methionine salvage pathway; potential Smt3p sumoylation substrate; expression downregulated by caspofungin and deletion mutant is caspofungin resistant	L-methionine salvage from methylthioadenosine	methylthioribulose 1-phosphate dehydratase activity	cytoplasm
YLL001W	YLL001W	DNM1	hom	Verified	0.490678302832386	0.311826997381195	no	1496	0.300309753019046	1025	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION|PEROXISOME ORGANIZATION	MITOCHONDRION		Dynamin-related GTPase required for mitochondrial fission and morphology; assembles on the cytoplasmic face of mitochondrial tubules at sites at which division will occur; also participates in endocytosis and regulating peroxisome abundance	mitochondrion inheritance|peroxisome fission|mitochondrial fission|chronological cell aging|peroxisome organization|mitochondrion organization|protein homooligomerization	protein homodimerization activity|GTPase activity|identical protein binding	mitochondrial outer membrane|mitochondrion|peroxisome
YER066W_p	YER066W	RRT13	hom	Uncharacterized	0.490348280392762	0.311943734022629	no	1497	0.285027068440432	1013	NA					Putative protein of unknown function; non-essential gene identified in a screen for mutants with decreased levels of rDNA transcription	biological_process	molecular_function	cellular_component
YBR104W	YBR104W	YMC2	hom	Verified	0.490291353209597	0.31196387240708	no	1498	0.280734380648849	965	NA	FT		MITOCHONDRION		Putative mitochondrial inner membrane transporter; proposed role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; YMC2 has a paralog, YMC1, that arose from the whole genome duplication	mitochondrial transport|transmembrane transport	organic acid transmembrane transporter activity	mitochondrion|integral to membrane
YMR006C	YMR006C	PLB2	hom	Verified	0.490121851002525	0.312023838312476	no	1499	0.269972827241869	937	NA	FT	LIPID METABOLISM			Phospholipase B (lysophospholipase) involved in phospholipid metabolism; displays transacylase activity in vitro; overproduction confers resistance to lysophosphatidylcholine	glycerophospholipid metabolic process	lysophospholipase activity	extracellular region|fungal-type cell wall
YLR037C	YLR037C	PAU23	hom	Verified	0.490110430721944	0.312027878719051	no	1500	0.31135000495406	1035	NA	FT	CELL WALL ORG/BIOGENESIS			Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; member of the seripauperin multigene family encoded mainly in subtelomeric regions; expressed under anaerobic conditions, completely repressed during aerobic growth	biological_process	molecular_function	fungal-type cell wall
YKR041W	YKR041W	YKR041W	hom	Verified	0.490073798267868	0.312040839149413	no	1501	0.297462866167461	982	NA	FT		NUCLEUS|CYTOSKELETON		Protein of unknown function; localizes to the mitotic spindle; overexpression of YKR041W affects endocytic protein trafficking	biological_process	molecular_function	nucleus|mitotic spindle|cytoplasm
YKL096C-B_p	YKL096C-B	YKL096C-B	hom	Uncharacterized	0.489645056955773	0.312192543576106	no	1502	0.325886451084215	1071	NA					Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching	biological_process	molecular_function	cellular_component
YPR101W	YPR101W	SNT309	hom	Verified	0.488877934701253	0.312464059075099	no	1503	0.324117108163827	1102	NA	FT	RNA PROCESSING	NUCLEUS		Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; interacts physically and genetically with Prp19p	mRNA splicing, via spliceosome	first spliceosomal transesterification activity	Prp19 complex|U2-type catalytic step 1 spliceosome
YMR247W-A_p	YMR247W-A	YMR247W-A	hom	Uncharacterized	0.488751040137541	0.312508981998117	no	1504	0.305659503233974	1025	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YNR067C	YNR067C	DSE4	hom	Verified	0.488728607570966	0.31251692381382	no	1505	0.265384407722667	908	NA	FT	CELL WALL ORG/BIOGENESIS|CELL DIVISION			Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother	cytokinesis, completion of separation	glucan endo-1,3-beta-D-glucosidase activity	fungal-type cell wall|extracellular region|cell septum
YGL252C	YGL252C	RTG2	hom	Verified	0.488059378942053	0.312753891279301	no	1506	0.326244337360056	1130	NA	FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|SIGNALING|RESPONSE TO NUTRIENT LEVELS	NUCLEUS|CHROMOSOME	HISTONE ACETYLTRANSFERASE	Sensor of mitochondrial dysfunction; regulates the subcellular location of Rtg1p and Rtg3p, transcriptional activators of the retrograde (RTG) and TOR pathways; Rtg2p is inhibited by the phosphorylated form of Mks1p	maintenance of DNA trinucleotide repeats|regulation of transcription from RNA polymerase II promoter|Unknown|nitrogen catabolite regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|mitochondria-nucleus signaling pathway|transcription factor import into nucleus	RNA polymerase II transcription factor binding transcription factor activity	SLIK (SAGA-like) complex|transcriptionally active chromatin|cytoplasm
YGR001C_p	YGR001C	YGR001C	hom	Uncharacterized	0.48788528303142	0.312815549670203	no	1507	0.285668054692322	969	NA					Putative protein of unknown function with similarity to methyltransferase family members; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; required for replication of Brome mosaic virus in S. cerevisiae	biological_process	methyltransferase activity	cytoplasm
YFL007W	YFL007W	BLM10	hom	Verified	0.487519439193603	0.312945135214366	no	1508	0.318117381750754	1066	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS	NUCLEUS		Proteasome activator; binds the core proteasome and stimulates proteasome-mediated protein degradation by inducing gate opening; required for resistance to bleomycin, may be involved in protecting against oxidative damage; similar to mammalian PA200	proteasome assembly|regulation of proteasomal protein catabolic process	proteasome binding|peptidase activator activity	proteasome core complex|proteasome complex|integral to membrane|nucleus
YHL046C	YHL046C	PAU13	hom	Verified	0.486460301812088	0.313320422537992	no	1509	0.296217217400496	981	NA					Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions; expression is induced after ethanol shock	biological_process	molecular_function	cellular_component
YPL018W	YPL018W	CTF19	hom	Verified	0.486179337824632	0.313420009821749	no	1510	0.356497716895762	1186	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME	KINETOCHORE	Outer kinetochore protein, needed for accurate chromosome segregation; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) that functions as a platform for kinetochore assembly; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-P and fission yeast fta2	attachment of spindle microtubules to kinetochore|chromosome segregation|establishment of mitotic sister chromatid cohesion	molecular_function	COMA complex|condensed nuclear chromosome kinetochore|nucleus
YJL186W	YJL186W	MNN5	hom	Verified	0.485915297119689	0.313513611072284	no	1511	0.295133932465332	1013	NA	FT	CARBOHYDRATE METABOLISM	GOLGI APPARATUS		Alpha-1,2-mannosyltransferase, responsible for addition of the second alpha-1,2-linked mannose of the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment	protein glycosylation	alpha-1,2-mannosyltransferase activity	Golgi apparatus
YJR009C	YJR009C	TDH2	hom	Verified	0.485222876322861	0.313759128182761	no	1512	0.290198578683659	988	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Glyceraldehyde-3-phosphate dehydrogenase, isozyme 2; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; protein abundance increases in response to DNA replication stress; TDH2 has a paralog, TDH3, that arose from the whole genome duplication	gluconeogenesis|reactive oxygen species metabolic process|glycolysis|apoptotic process	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity	mitochondrion|fungal-type cell wall|lipid particle|plasma membrane|cytoplasm
YLR371W	YLR371W	ROM2	hom	Verified	0.484542097560389	0.314000597718896	no	1513	0.395856865946909	1296	NA	FF|FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING|CELL WALL ORG/BIOGENESIS|NUCLEOTIDE METABOLISM	SITE OF POLARIZED GROWTH		GDP/GTP exchange factor (GEF) for Rho1p and Rho2p; mutations are synthetically lethal with mutations in rom1, which also encodes a GEF; Rom2p localization to the bud surface is dependent on Ack1p	regulation of fungal-type cell wall organization|positive regulation of endocytosis|establishment of cell polarity|small GTPase mediated signal transduction|negative regulation of cAMP-mediated signaling|activation of Rho GTPase activity	phosphatidylinositol-4,5-bisphosphate binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity	incipient cellular bud site|mating projection tip|cellular bud tip
YGL240W	YGL240W	DOC1	hom	Verified	0.484498440836111	0.31401608530554	no	1514	0.322489905118774	1094	NA	FT	CELL CYCLE|CHROMATIN ORGANIZATION|CELL DIVISION|PROTEOLYSIS	NUCLEUS|MITOCHONDRION	UBIQUITIN LIGASE COMPLEX	Processivity factor required for the ubiquitination activity of the anaphase promoting complex (APC), mediates the activity of the APC by contributing to substrate recognition; involved in cyclin proteolysis; contains a conserved DOC1 homology domain	activation of mitotic anaphase-promoting complex activity|chromatin assembly|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cyclin catabolic process	enzyme regulator activity|mitotic anaphase-promoting complex activity	mitochondrion|anaphase-promoting complex
YJR032W	YJR032W	CPR7	hom	Verified	0.483679257144003	0.31430675826529	no	1515	0.327311763937127	1120	NA					Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity	protein refolding|response to stress	unfolded protein binding|peptidyl-prolyl cis-trans isomerase activity	cytosol
YPL127C	YPL127C	HHO1	hom	Verified	0.483436090423435	0.314393063888422	no	1516	0.306571297600264	1048	NA	FT	CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS|CHROMOSOME		Histone H1, linker histone with roles in meiosis and sporulation; decreasing levels early in sporulation may promote meiosis, and increasing levels during sporulation facilitate compaction of spore chromatin; binds to promoters and within genes in mature spores; may be recruited by Ume6p to promoter regions, contributing to transcriptional repression outside of meiosis; suppresses DNA repair involving homologous recombination	negative regulation of DNA recombination|negative regulation of chromatin silencing|regulation of transcription, DNA-dependent	DNA binding	nucleus|nuclear nucleosome
YER024W	YER024W	YAT2	hom	Verified	0.4827188791487	0.314647678222343	no	1517	0.316497059140736	1040	NA	FT	KETONE METABOLISM|LIPID METABOLISM|AMINO ACID METABOLISM			Carnitine acetyltransferase; has similarity to Yat1p, which is a carnitine acetyltransferase associated with the mitochondrial outer membrane	carnitine metabolic process|alcohol metabolic process	carnitine O-acetyltransferase activity	cytosol|cytoplasm
YAL020C	YAL020C	ATS1	hom	Verified	0.481922878856372	0.31493036635478	no	1518	0.32134833218156	1103	NA	FT	RNA PROCESSING|CELL DIVISION|CYTOSKELETON ORGANIZATION			Protein required, with Elongator complex, Kti11p, and Kti12p, for modification of wobble nucleosides in tRNA; has a potential role in regulatory interactions between microtubules and the cell cycle	microtubule-based process|budding cell bud growth|microtubule cytoskeleton organization|tRNA wobble uridine modification	molecular_function	cytoplasm
YOR245C	YOR245C	DGA1	hom	Verified	0.480538313806686	0.315422333180955	no	1519	0.312529944406136	1043	NA	FT	LIPID METABOLISM|CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Diacylglycerol acyltransferase, catalyzes the terminal step of triacylglycerol (TAG) formation, acylates diacylglycerol using acyl-CoA as an acyl donor, localized to lipid particles	lipid storage|triglyceride biosynthetic process	diacylglycerol O-acyltransferase activity	integral to membrane|lipid particle
YFR014C	YFR014C	CMK1	hom	Verified	0.478974037910284	0.315978549178758	no	1520	0.295652917892895	985	NA	FT	SIGNALING|PROTEIN PHOSPHORYLATION			Calmodulin-dependent protein kinase; may play a role in stress response, many Ca++/calmodulin dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to mammalian Cam Kinase II; CMK1 has a paralog, CMK2, that arose from the whole genome duplication	signal transduction|protein phosphorylation	protein kinase activity|calmodulin-dependent protein kinase activity	cytoplasm
YGR054W	YGR054W	YGR054W	hom	Verified	0.478707691282498	0.316073296706402	no	1521	0.310100623364464	1086	NA	FT	TRANSLATION			Eukaryotic initiation factor (eIF) 2A; associates specifically with both 40S subunits and 80 S ribosomes, and interacts genetically with both eIF5b and eIF4E; homologous to mammalian eIF2A	translational initiation	translation initiation factor activity	cytosolic ribosome|cytosolic small ribosomal subunit|ribosome
YER086W	YER086W	ILV1	hom	Verified	0.477978562826042	0.316332731476074	no	1522	0.350663344563237	1165	NA	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		Threonine deaminase, catalyzes the first step in isoleucine biosynthesis; expression is under general amino acid control; ILV1 locus exhibits highly positioned nucleosomes whose organization is independent of known ILV1 regulation	threonine catabolic process|isoleucine biosynthetic process	L-threonine ammonia-lyase activity	mitochondrion
YHR075C	YHR075C	PPE1	hom	Verified	0.477045077172541	0.316665011568128	no	1523	0.314652854625854	1063	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Protein with carboxyl methyl esterase activity that may have a role in demethylation of the phosphoprotein phosphatase catalytic subunit; also identified as a small subunit mitochondrial ribosomal protein	cellular protein modification process|mitochondrial translation	structural constituent of ribosome|carboxylesterase activity	mitochondrial small ribosomal subunit
YLR449W	YLR449W	FPR4	hom	Verified	0.47701500219839	0.316675719406589	no	1524	0.318058090941032	1074	NA	FT	CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS|CHROMOSOME		Peptidyl-prolyl cis-trans isomerase (PPIase) (proline isomerase) localized to the nucleus; catalyzes isomerization of proline residues in histones H3 and H4, which affects lysine methylation of those histones	histone peptidyl-prolyl isomerization|negative regulation of histone H3-K36 methylation|regulation of transcription by chromatin organization|chromatin silencing at rDNA|nucleosome assembly	peptidyl-prolyl cis-trans isomerase activity|macrolide binding	chromatin|nucleus
YIR007W_p	YIR007W	YIR007W	hom	Uncharacterized	0.476830378059539	0.316741456011061	no	1525	0.307050902212877	1000	NA	FT	CARBOHYDRATE METABOLISM			Putative glycosidase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YIR007W is a non-essential gene	biological_process	molecular_function	cytoplasm
YBR296C	YBR296C	PHO89	hom	Verified	0.475419767313211	0.317243903886094	no	1526	0.321428899371702	1106	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Na+/Pi cotransporter, active in early growth phase; similar to phosphate transporters of Neurospora crassa; transcription regulated by inorganic phosphate concentrations and Pho4p; mutations in related human transporter genes hPit1 and hPit2 are associated with hyperphosphatemia-induced calcification of vascular tissue and familial idiopathic basal ganglia calcification	phosphate ion transport|transmembrane transport	sodium:inorganic phosphate symporter activity	integral to membrane|plasma membrane
YPL110C	YPL110C	GDE1	hom	Verified	0.474906944368218	0.317426650761359	no	1527	0.327007523365542	1111	NA	FT	LIPID METABOLISM|SIGNALING|CARBOHYDRATE METABOLISM			Glycerophosphocholine (GroPCho) phosphodiesterase; hydrolyzes GroPCho to choline and glycerolphosphate, for use as a phosphate source and as a precursor for phosphocholine synthesis; may interact with ribosomes	glycerophospholipid catabolic process	glycerophosphocholine phosphodiesterase activity	ribosome|cytoplasm
YJR090C	YJR090C	GRR1	hom	Verified	0.472563864415494	0.318262184087334	no	1528	0.353297902623435	1180	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CARBOHYDRATE METABOLISM|PROTEOLYSIS	NUCLEUS|SITE OF POLARIZED GROWTH|CYTOSKELETON	UBIQUITIN LIGASE COMPLEX	F-box protein component of the SCF ubiquitin-ligase complex; involved in carbon catabolite repression, glucose-dependent divalent cation transport, high-affinity glucose transport, morphogenesis, and sulfite detoxification	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|cellular response to methylmercury|cell cycle arrest in response to pheromone|G1/S transition of mitotic cell cycle|response to DNA damage stimulus|protein ubiquitination	ubiquitin-protein ligase activity|protein binding, bridging	cellular bud neck contractile ring|SCF ubiquitin ligase complex|nucleus|cytoplasm
YPL054W	YPL054W	LEE1	hom	Verified	0.468962088742315	0.319548367351003	no	1529	0.289830335835763	998	NA					Zinc-finger protein of unknown function	biological_process	molecular_function	cellular_component
YDR046C	YDR046C	BAP3	hom	Verified	0.468553133846518	0.319694541612669	no	1530	0.298325369594614	1018	NA	FT		MITOCHONDRION|PLASMA MEMBRANE		Amino acid permease; involved in uptake of cysteine, leucine, isoleucine and valine; BAP3 has a paralog, BAP2, that arose from the whole genome duplication	amino acid transport|transmembrane transport	amino acid transmembrane transporter activity	mitochondrion|integral to membrane|plasma membrane
YMR158C-A_p	YMR158C-A	YMR158C-A	hom	Uncharacterized	0.467405095890734	0.320105038701372	no	1531	0.297156039522813	1004	NA					Putative protein of unknown function, may contain a lipid attachment site; YMR158C-A is not an essential gene	biological_process	molecular_function	cellular_component
YDR132C	YDR132C	YDR132C	hom	Verified	0.467289739678643	0.320146298123394	no	1532	0.320065352587235	1062	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	NUCLEUS|PLASMA MEMBRANE		Protein of unknown function; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress; YDR132C has a paralog, YLR108C, that arose from the whole genome duplication	biological_process	molecular_function	nucleus|cytoplasm
YJL107C_p	YJL107C	YJL107C	hom	Uncharacterized	0.466239954540523	0.320521876626223	no	1533	0.306416351759917	1048	NA					Putative protein of unknown function; expression is induced by activation of the HOG1 mitogen-activated signaling pathway and this induction is Hog1p/Pbs2p dependent; YJL107C and adjacent ORF, YJL108C are merged in related fungi	biological_process	molecular_function	cellular_component
YOR022C_p	YOR022C	YOR022C	hom	Uncharacterized	0.465933598666077	0.320631515328667	no	1534	0.312112412347301	1043	NA	FT	LIPID METABOLISM	MITOCHONDRION		Putative carboxylic ester hydrolase; similar to bovine phospholipase A1; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	phospholipase activity	mitochondrion
YMR326C_d	YMR326C	YMR326C	hom	Dubious	0.465781363775409	0.32068600300376	no	1535	0.31272392156994	1039	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the telomere on the right arm of chromosome 13	Unknown	Unknown	Unknown
YCL064C	YCL064C	CHA1	hom	Verified	0.464877395538494	0.321009629463274	no	1536	0.32253464230897	1071	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		Catabolic L-serine (L-threonine) deaminase, catalyzes the degradation of both L-serine and L-threonine; required to use serine or threonine as the sole nitrogen source, transcriptionally induced by serine and threonine	threonine catabolic process|L-serine catabolic process	L-threonine ammonia-lyase activity|L-serine ammonia-lyase activity	mitochondrial nucleoid|mitochondrion
YPL048W	YPL048W	CAM1	hom	Verified	0.464707816565637	0.321070354988093	no	1537	0.326775273634867	1112	NA	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION	NUCLEUS		Nuclear protein required for transcription of MXR1; binds the MXR1 promoter in the presence of other nuclear factors; binds calcium and phospholipids; has similarity to translational cofactor EF-1 gamma	ribosome biogenesis|positive regulation of transcription from RNA polymerase II promoter	phospholipid binding|transcription coactivator activity|calcium ion binding	nucleus
YGR213C	YGR213C	RTA1	hom	Verified	0.464629423283487	0.321098428913954	no	1538	0.292214565513246	995	NA	FT		PLASMA MEMBRANE		Protein involved in 7-aminocholesterol resistance; has seven potential membrane-spanning regions; expression is induced under both low-heme and low-oxygen conditions; member of the fungal lipid-translocating exporter (LTE) family of protein	biological_process	molecular_function	integral to membrane|plasma membrane
YBL027W	YBL027W	RPL19B	hom	Verified	0.46451597263412	0.321139059271319	no	1539	0.30236311303344	1036	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L19B; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal; homologous to mammalian ribosomal protein L19, no bacterial homolog; RPL19B has a paralog, RPL19A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YBR059C	YBR059C	AKL1	hom	Verified	0.462662446936353	0.321803169912345	no	1540	0.325090321132617	1092	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION	SITE OF POLARIZED GROWTH		Ser-Thr protein kinase, member (with Ark1p and Prk1p) of the Ark kinase family; involved in endocytosis and actin cytoskeleton organization	regulation of endocytosis|protein phosphorylation|actin cytoskeleton organization	protein kinase activity	cellular bud neck|cytoplasm
YBR063C_p	YBR063C	YBR063C	hom	Uncharacterized	0.462083804158744	0.322010612024872	no	1541	0.310654251302436	1066	NA					Putative protein of unknown function; YBR063C is not an essential gene	biological_process	molecular_function	cellular_component
YDL020C	YDL020C	RPN4	hom	Verified	0.461942581073742	0.322061248601544	no	1542	0.413937455499466	1347	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO DNA DAMAGE|PROTEOLYSIS	NUCLEUS		Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses; relative distribution to the nucleus increases upon DNA replication stress	positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance|regulation of DNA repair|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter in response to stress|positive regulation of transcription from RNA polymerase II promoter in response to stress|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YDR096W	YDR096W	GIS1	hom	Verified	0.461134494845574	0.322351057375471	no	1543	0.316537256569128	1055	NA	FT	TRANSCRIPTION FROM RNA POL II|LIPID METABOLISM|CHROMATIN ORGANIZATION|RESPONSE TO NUTRIENT LEVELS	NUCLEUS|MITOCHONDRION		Histone demethylase and transcription factor; regulates genes during nutrient limitation; negatively regulates DPP1, PHR1; activity modulated by limited proteasome-mediated proteolysis; has JmjC and JmjN domain in N-terminal region that interact, promoting stability and proper transcriptional activity; contains two transactivating domains downstream of Jmj domains and a C-terminal DNA binding domain; GIS1 has a paralog, RPH1, that arose from the whole genome duplication	negative regulation of transcription from RNA polymerase II promoter|chronological cell aging|regulation of phospholipid biosynthetic process|histone demethylation|positive regulation of transcription from RNA polymerase II promoter|maintenance of stationary phase in response to starvation	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|histone demethylase activity (H3-K36 specific)	mitochondrion|nucleus
YJR098C_p	YJR098C	YJR098C	hom	Uncharacterized	0.461010650706315	0.322395481885337	no	1544	0.300842958297366	1013	NA	FT	LIPID METABOLISM	MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion|cytoplasm
YKL194C	YKL194C	MST1	hom	Verified	0.460851993899273	0.322452397859752	no	1545	0.350185953027721	1172	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial threonyl-tRNA synthetase; aminoacylates both the canonical threonine tRNA tT(UGU)Q1 and the unusual threonine tRNA tT(XXX)Q2 in vitro	mitochondrial threonyl-tRNA aminoacylation	threonine-tRNA ligase activity	mitochondrion
YGR078C	YGR078C	PAC10	hom	Verified	0.459964142111505	0.322770979404519	no	1546	0.351054782164384	1161	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS			Part of the heteromeric co-chaperone GimC/prefoldin complex, which promotes efficient protein folding	tubulin complex assembly	tubulin binding	prefoldin complex|polysome|cytoplasm
YGR196C	YGR196C	FYV8	hom	Verified	0.459298231788627	0.323010008683196	no	1547	0.323903064754967	1076	NA					Protein of unknown function, required for survival upon exposure to K1 killer toxin	biological_process	molecular_function	cytoplasm
YFR043C	YFR043C	IRC6	hom	Verified	0.458150293861703	0.323422233945699	no	1548	0.323703766962633	1097	NA					Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci	biological_process	molecular_function	cellular_component
YMR291W	YMR291W	TDA1	hom	Verified	0.457326918326985	0.323718042220767	no	1549	0.308151650379127	1031	NA	FT	PROTEIN PHOSPHORYLATION	NUCLEUS		Protein kinase of unknown cellular role; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; null mutant is sensitive to expression of the top1-T722A allele; not an essential gene; relocalizes from nucleus to cytoplasm upon DNA replication stress	protein phosphorylation	protein kinase activity	nucleus|cytoplasm
YBR179C	YBR179C	FZO1	hom	Verified	0.455503101197752	0.324373668502426	no	1550	0.330240401211429	1091	NA	FT	MEMBRANE ORGANIZATION|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitofusin; integral membrane protein involved in mitochondrial outer membrane tethering and fusion; role in mitochondrial genome maintenance; efficient tethering and degradation of Fzo1p requires an intact N-terminal GTPase domain; targeted for destruction by the ubiquitin ligase SCF-Mdm30p and the cytosolic ubiquitin-proteasome system	mitochondrial fusion	GTPase activity|protein homodimerization activity	mitochondrial outer membrane|mitochondrion|mitochondrial inner membrane|integral to mitochondrial outer membrane
YDR056C_p	YDR056C	YDR056C	hom	Uncharacterized	0.454568705068945	0.324709776681768	no	1551	0.317187258582426	1065	NA	FT		ENDOPLASMIC RETICULUM		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDR056C is not an essential protein	biological_process	molecular_function	endoplasmic reticulum
YMR306C-A_d	YMR306C-A	YMR306C-A	hom	Dubious	0.454122147467815	0.324870456708346	no	1552	0.310969436663942	1044	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YOL008W	YOL008W	COQ10	hom	Verified	0.452856672849206	0.325325975793239	no	1553	0.314083254442833	1074	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Coenzyme Q (ubiquinone) binding protein, functions in the delivery of Q<sub>6</sub> to its proper location for electron transport during respiration; START domain protein with homologs in bacteria and eukaryotes	cellular respiration	ubiquinone binding	mitochondrion|mitochondrial inner membrane
YGR017W_p	YGR017W	YGR017W	hom	Uncharacterized	0.452719534354902	0.325375355732571	no	1554	0.300097730905769	982	NA	FT	OXIDATION-REDUCTION PROCESS	NUCLEUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm	biological_process	molecular_function	nucleus|cytoplasm
YDR379C-A	YDR379C-A	YDR379C-A	hom	Verified	0.451790862093815	0.325709826654505	no	1555	0.331314188141698	1128	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Protein involved in the assembly of the mitochondrial succinate dehydrogenase complex; mutations in human ortholog SDHAF1 are associated with infantile leukoencephalopathy	mitochondrial respiratory chain complex II assembly	molecular_function	mitochondrion
YPR164W	YPR164W	MMS1	hom	Verified	0.450742596812476	0.326087538867238	no	1556	0.330032303289851	1143	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS	UBIQUITIN LIGASE COMPLEX	Subunit of an E3 ubiquitin ligase complex involved in replication repair; stabilizes protein components of the replication fork such as the fork-pausing complex and leading strand polymerase, preventing fork collapse and promoting efficient recovery during replication stress; regulates Ty1 transposition; involved with Rtt101p in nonfunctional rRNA decay	replication fork processing|negative regulation of transposition, RNA-mediated|recombinational repair|nonfunctional rRNA decay	molecular_function	Cul8-RING ubiquitin ligase complex
YGL249W	YGL249W	ZIP2	hom	Verified	0.450723724331508	0.326094340659214	no	1557	0.293150587375487	982	NA	FT	CELL CYCLE|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME		Meiosis-specific protein; involved in normal synaptonemal complex formation and pairing between homologous chromosomes during meiosis; relocalizes from mitochondrion to cytoplasm upon DNA replication stress	synaptonemal complex assembly|synapsis|reciprocal meiotic recombination	molecular_function	synaptonemal complex
YPL152W-A_p	YPL152W-A	YPL152W-A	hom	Uncharacterized	0.450577236686192	0.326147137936925	no	1558	0.317322323334043	1090	NA					Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching	biological_process	molecular_function	cellular_component
YKR030W	YKR030W	GMH1	hom	Verified	0.449917286945446	0.326385041129176	no	1559	0.312540380242565	1071	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Golgi membrane protein of unknown function, interacts with Gea1p and Gea2p; required for localization of Gea2p; computational analysis suggests a possible role in either cell wall synthesis or protein-vacuolar targeting	transport	molecular_function	integral to membrane|integral to Golgi membrane
YDL185W	YDL185W	VMA1	hom	Verified	0.448986121291052	0.326720834235032	no	1560	0.382890355178126	1258	NA	FF|FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS	ENDOMEMBRANE SYSTEM		Subunit A of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase; protein precursor undergoes self-catalyzed splicing to yield the extein Tfp1p and the intein Vde (PI-SceI), which is a site-specific endonuclease	intron homing|cellular protein metabolic process|vacuolar acidification	endodeoxyribonuclease activity|proton-transporting ATPase activity, rotational mechanism	vacuolar proton-transporting V-type ATPase, V1 domain|fungal-type vacuole membrane
YLR199C	YLR199C	PBA1	hom	Verified	0.448962043121393	0.326729519068373	no	1561	0.297404448863209	1025	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS			Protein involved in 20S proteasome assembly; forms a heterodimer with Add66p that binds to proteasome precursors; similar to human PAC1 constituent of the PAC1-PAC2 complex involved in proteasome assembly	proteasome assembly	molecular_function	cytoplasm
YPL087W	YPL087W	YDC1	hom	Verified	0.448152915147635	0.327021420630987	no	1562	0.304264592279155	1045	NA	FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Alkaline dihydroceramidase, involved in sphingolipid metabolism; preferentially hydrolyzes dihydroceramide to a free fatty acid and dihydrosphingosine; has a minor reverse activity; YDC1 has a paralog, YPC1, that arose from the whole genome duplication	ceramide catabolic process|ceramide biosynthetic process	dihydroceramidase activity	integral to membrane|endoplasmic reticulum
YDR536W	YDR536W	STL1	hom	Verified	0.4473236177828	0.327320708373488	no	1563	0.316206148553351	1079	NA	FT		PLASMA MEMBRANE		Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock	transport|glycerol transport|transmembrane transport	solute:hydrogen symporter activity|transporter activity	integral to membrane|plasma membrane|membrane
YGL194C	YGL194C	HOS2	hom	Verified	0.446010078344604	0.327794982939231	no	1564	0.315193071465238	1072	NA	FT	CELL CYCLE|CHROMATIN ORGANIZATION|SIGNALING	NUCLEUS|CHROMOSOME		Histone deacetylase and subunit of Set3 and Rpd3L complexes; required for gene activation via specific deacetylation of lysines in H3 and H4 histone tails; subunit of the Set3 complex, a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity; co-localizes with Cmr1p in nuclear foci in response to DNA damage by MMS	negative regulation of meiosis|chromatin organization|regulation of transcription, DNA-dependent|positive regulation of stress-activated MAPK cascade|histone deacetylation	NAD-independent histone deacetylase activity|NAD-dependent histone deacetylase activity	Rpd3L-Expanded complex|Set3 complex
YJR092W	YJR092W	BUD4	hom	Verified	0.445912296060276	0.327830299930776	no	1565	0.319860636965472	1075	NA	FT	CELL CYCLE|CELL DIVISION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Anillin-like protein involved in bud-site selection; required for the axial budding pattern; localizes with septins to the bud neck in mitosis and may constitute an axial landmark for the next round of budding; required for the formation and disassembly of the double septin ring structure, and generally for septin organization; in vivo substrate of Cdc28p/Clb2p	cellular bud site selection|axial cellular bud site selection	GTP binding	cellular bud neck contractile ring
YPL240C	YPL240C	HSP82	hom	Verified	0.444929452369658	0.328185368758589	no	1566	0.343255348356448	1189	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION			Hsp90 chaperone; redundant in function with Hsc82p; required for pheromone signaling, negative regulation of Hsf1p; docks with Tom70p for mitochondrial preprotein delivery; promotes telomerase DNA binding, nucleotide addition; protein abundance increases in response to DNA replication stress; contains two acid-rich unstructured regions that promote solubility of chaperone-substrate complexes; HSP82 has a paralog, HSC82, that arose from the whole genome duplication	proteasome assembly|positive regulation of telomere maintenance via telomerase|box C/D snoRNP assembly|response to stress|protein refolding|protein targeting to mitochondrion|response to osmotic stress|'de novo' protein folding	unfolded protein binding|ATPase activity, coupled	cytoplasm
YHR064C	YHR064C	SSZ1	hom	Verified	0.443700970164747	0.328629396978817	no	1567	0.283980366970744	1013	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION			Hsp70 protein that interacts with Zuo1p (a DnaJ homolog) to form a ribosome-associated complex that binds the ribosome via the Zuo1p subunit; also involved in pleiotropic drug resistance via sequential activation of PDR1 and PDR5; binds ATP	cytoplasmic translation|regulation of translational fidelity|rRNA processing	unfolded protein binding	polysome|cytoplasm
YPL114W_d	YPL114W	YPL114W	hom	Dubious	0.442328669003289	0.329125694023649	no	1568	0.319317669100927	1095	NA					Dubious open reading frame, unlikely to encode a functional protein; largely overlaps ORF YPL113C; diploid deletion in BY4743 strain background exhibits high budding index	Unknown	Unknown	Unknown
YIL013C	YIL013C	PDR11	hom	Verified	0.440758063440721	0.329694078249812	no	1569	0.33423890660487	1102	NA	FT	NUCLEOTIDE METABOLISM			ATP-binding cassette (ABC) transporter, multidrug transporter involved in multiple drug resistance; mediates sterol uptake when sterol biosynthesis is compromised; regulated by Pdr1p; required for anaerobic growth	sterol transport	ATPase activity, coupled to transmembrane movement of substances	integral to membrane|membrane
YKR013W	YKR013W	PRY2	hom	Verified	0.44044711935417	0.329806652077416	no	1570	0.349995355622081	1199	NA					Sterol binding protein involved in the export of acetylated sterols; secreted glycoprotein and member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis related 1 proteins); sterol export function is redundant with that of PRY1; may be involved in detoxification of hydrophobic compounds; PRY2 has a paralog, PRY1, that arose from the whole genome duplication	biological_process	molecular_function	extracellular region|fungal-type vacuole
YLR151C	YLR151C	PCD1	hom	Verified	0.440193201775207	0.329898591532622	no	1571	0.329890885765732	1081	NA	FT	NUCLEOTIDE METABOLISM			Peroxisomal pyrophosphatase with specificity for coenzyme A and CoA derivatives, may function to remove potentially toxic oxidized CoA disulfide from peroxisomes to maintain the capacity for beta-oxidation of fatty acids; nudix hydrolase family member	biological_process	pyrophosphatase activity	peroxisome
YML017W	YML017W	PSP2	hom	Verified	0.439848225648115	0.330023518282724	no	1572	0.348180531689996	1185	NA					Asn rich cytoplasmic protein that contains RGG motifs; high-copy suppressor of group II intron-splicing defects of a mutation in MRS2 and of a conditional mutation in POL1 (DNA polymerase alpha); possible role in mitochondrial mRNA splicing	biological_process	molecular_function	cytoplasm
YLR043C	YLR043C	TRX1	hom	Verified	0.439370503912746	0.330196547710316	no	1573	0.327821147286373	1111	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|RESPONSE TO OXIDATIVE STRESS	ENDOMEMBRANE SYSTEM|NUCLEUS|GOLGI APPARATUS		Cytoplasmic thioredoxin isoenzyme; part of the thioredoxin system which protects cells against oxidative and reductive stress; forms LMA1 complex with Pbi2p; acts as a cofactor for Tsa1p, required for ER-Golgi transport and vacuole inheritance; protein abundance increases in response to DNA replication stress	vacuole inheritance|regulation of DNA replication|cell redox homeostasis|protein deglutathionylation|retrograde vesicle-mediated transport, Golgi to ER|cellular response to oxidative stress|ER to Golgi vesicle-mediated transport|vacuole fusion, non-autophagic	disulfide oxidoreductase activity	cytosol|fungal-type vacuole
YOR238W_p	YOR238W	YOR238W	hom	Uncharacterized	0.439354585716451	0.330202313860353	no	1574	0.319188210858398	1060	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	biological_process	molecular_function	cytoplasm
YKR012C_d	YKR012C	YKR012C	hom	Dubious	0.43921496107554	0.330252892714952	no	1575	0.299531718309879	1035	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PRY2	Unknown	Unknown	Unknown
YOR301W	YOR301W	RAX1	hom	Verified	0.439209724558711	0.330254789697092	no	1576	0.295140483246611	996	NA	FT	CELL CYCLE|SIGNALING|CELL DIVISION	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Protein involved in bud site selection during bipolar budding; localization requires Rax2p; has similarity to members of the insulin-related peptide superfamily	cellular bud site selection	molecular_function	integral to membrane|cellular bud neck
YPR061C	YPR061C	JID1	hom	Verified	0.437574514697456	0.330847374495307	no	1577	0.322451046172579	1100	NA	FT		MITOCHONDRION		Probable Hsp40p co-chaperone, has a DnaJ-like domain and appears to be involved in ER-associated degradation of misfolded proteins containing a tightly folded cytoplasmic domain; inhibits replication of Brome mosaic virus in S. cerevisiae	biological_process	molecular_function	mitochondrion
YDR386W	YDR386W	MUS81	hom	Verified	0.437351247159489	0.330928317507446	no	1578	0.380582821557322	1274	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION	NUCLEUS		Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in DNA repair, replication fork stability, and joint molecule formation/resolution during meiotic recombination; helix-hairpin-helix protein; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates the function of Mms4p-Mus81p	DNA repair|DNA topological change|reciprocal meiotic recombination|resolution of meiotic recombination intermediates|response to DNA damage stimulus	crossover junction endodeoxyribonuclease activity|endonuclease activity	Holliday junction resolvase complex|nucleus
YMR166C_p	YMR166C	YMR166C	hom	Uncharacterized	0.437349236622329	0.33092904643989	no	1579	0.338946435038877	1110	NA	FT		MITOCHONDRION		Predicted transporter of the mitochondrial inner membrane; has similarity to human mitochondrial ATP-Mg/Pi carriers; YMR166C is not an essential gene	transport	transporter activity	integral to membrane|mitochondrial inner membrane
YIL015W	YIL015W	BAR1	hom	Verified	0.437001563857128	0.33105510694676	no	1580	0.330527433296836	1097	NA	FT	SIGNALING|PROTEOLYSIS			Aspartyl protease secreted into the periplasmic space of mating type a cells, helps cells find mating partners, cleaves and inactivates alpha factor allowing cells to recover from alpha-factor-induced cell cycle arrest	adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion|peptide catabolic process	aspartic-type endopeptidase activity	cell wall-bounded periplasmic space
YPL236C	YPL236C	ENV7	hom	Verified	0.436660931834406	0.331178633171019	no	1581	0.307674148223854	1060	NA	FT	PROTEIN PHOSPHORYLATION|VACUOLAR PROTEIN PROCESSING			Vacuolar membrane protein kinase; negatively regulates membrane fusion; associates with vacuolar membrane through palmitoylation of one or more cysteines in consensus sequence; vacuolar membrane association is essential to its kinase activity; mutant shows defect in CPY processing; ortholog of human serine/threonine kinase 16 (STK16)	vacuolar protein processing	protein serine/threonine kinase activity	fungal-type vacuole membrane
YML011C	YML011C	RAD33	hom	Verified	0.43592684686884	0.331444902962508	no	1582	0.316700566177976	1042	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		Protein involved in nucleotide excision repair; green fluorescent protein (GFP)-fusion protein localizes to the nucleus	nucleotide-excision repair	molecular_function	nucleus
YFR010W	YFR010W	UBP6	hom	Verified	0.435801314792355	0.331490444919522	no	1583	0.362239084342199	1198	NA	FT	PROTEOLYSIS			Ubiquitin-specific protease situated in the base subcomplex of the 26S proteasome, releases free ubiquitin from branched polyubiquitin chains; works in opposition to Hul5p polyubiquitin elongation activity; mutant has aneuploidy tolerance	protein deubiquitination	ubiquitin-specific protease activity	proteasome complex|proteasome regulatory particle
YPL027W	YPL027W	SMA1	hom	Verified	0.435557546192328	0.331578889186014	no	1584	0.307213996690708	1028	NA	FT	MEMBRANE ORGANIZATION			Protein of unknown function involved in the assembly of the prospore membrane during sporulation; interacts with Spo14p	ascospore-type prospore membrane assembly	molecular_function	prospore membrane
YPR084W_p	YPR084W	YPR084W	hom	Uncharacterized	0.434872810153684	0.331827375742209	no	1585	0.336244223886879	1124	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YFL015C_d	YFL015C	YFL015C	hom	Dubious	0.434319846234513	0.332028097011553	no	1586	0.325955914787697	1063	NA					Dubious open reading frame unlikely to encode a protein; partially overlaps dubious ORF YFL015W-A; YFL015C is not an essential gene	Unknown	Unknown	Unknown
YNL301C	YNL301C	RPL18B	hom	Verified	0.434138419155716	0.332093964027476	no	1587	0.316195784152095	1068	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L18B; homologous to mammalian ribosomal protein L18, no bacterial homolog; RPL18B has a paralog, RPL18A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YIL096C_p	YIL096C	YIL096C	hom	Uncharacterized	0.433630590339386	0.332278358620999	no	1588	0.325871240073538	1081	NA	FT		NUCLEUS		Putative S-adenosylmethionine-dependent methyltransferase; associates with precursors of the 60S ribosomal subunit; predicted to be involved in ribosome biogenesis	biological_process	S-adenosylmethionine-dependent methyltransferase activity	nucleolus|nucleus
YOL162W_p	YOL162W	YOL162W	hom	Uncharacterized	0.432149962930761	0.332816211787634	no	1589	0.32049490337184	1067	NA					Putative protein of unknown function; member of the Dal5p subfamily of the major facilitator family	transmembrane transport	transmembrane transporter activity	integral to membrane|membrane
YBR111W-A	YBR111W-A	SUS1	hom	Verified	0.431820293144132	0.332936014627995	no	1590	0.398242891128396	1322	NA	FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE|HISTONE ACETYLTRANSFERASE	Component of both the SAGA histone acetylase and TREX-2 complexes; interacts with RNA polymerase II; involved in mRNA export coupled transcription activation and elongation; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP	poly(A)+ mRNA export from nucleus|regulation of protein localization|nuclear retention of pre-mRNA at the site of transcription|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|histone deubiquitination|histone H3-K4 methylation|transcription elongation from RNA polymerase II promoter|histone H3-K79 methylation|positive regulation of transcription from RNA polymerase II promoter	enzyme activator activity	DUBm complex|nucleoplasm|transcription export complex 2|SAGA complex|nuclear pore
YGR019W	YGR019W	UGA1	hom	Verified	0.430386300183807	0.333457329637009	no	1591	0.324783146778136	1083	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Gamma-aminobutyrate (GABA) transaminase; also known as 4-aminobutyrate aminotransferase; involved in the 4-aminobutyrate and glutamate degradation pathways; required for normal oxidative stress tolerance and nitrogen utilization; protein abundance increases in response to DNA replication stress	nitrogen utilization|gamma-aminobutyric acid catabolic process	4-aminobutyrate transaminase activity	intracellular
YJR036C	YJR036C	HUL4	hom	Verified	0.429605196303458	0.333741428255112	no	1592	0.339216359311851	1128	NA	FT	PROTEOLYSIS	NUCLEUS		Protein with similarity to hect domain E3 ubiquitin-protein ligases; not essential for viability; found in association with Trf4 in TRAMP complex	protein ubiquitination	ubiquitin-protein ligase activity	TRAMP complex
YAL048C	YAL048C	GEM1	hom	Verified	0.429352960558467	0.333833190365489	no	1593	0.313848686329258	1076	NA	FT	SIGNALING|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION		Outer mitochondrial membrane GTPase, subunit of the ERMES complex; potential regulatory subunit of the ERMES complex that links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth; cells lacking Gem1p contain collapsed, globular, or grape-like mitochondria; ortholog of metazoan Miro GTPases	mitochondrion inheritance|regulation of mitochondrion organization|phospholipid homeostasis	GTPase activity|calcium ion binding	mitochondrial outer membrane|ERMES complex|mitochondrion
YGR123C	YGR123C	PPT1	hom	Verified	0.428843312987965	0.334018627940226	no	1594	0.33658218309601	1106	NA	FT		NUCLEUS		Protein serine/threonine phosphatase, regulates Hsp90 chaperone by affecting its ATPase and cochaperone binding activities; has similarity to human phosphatase PP5; present in both the nucleus and cytoplasm; expressed during logarithmic growth	protein dephosphorylation	protein serine/threonine phosphatase activity	nucleus|cytoplasm
YLR108C	YLR108C	YLR108C	hom	Verified	0.428618040225562	0.334100607374468	no	1595	0.349257149227921	1165	NA	FT		NUCLEUS		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YLR108C is not an esssential gene; protein abundance increases in response to DNA replication stress; YLR108C has a paralog, YDR132C, that arose from the whole genome duplication	biological_process	molecular_function	nucleus
YGR194C	YGR194C	XKS1	hom	Verified	0.42835602407437	0.334195968122132	no	1596	0.312676471151969	1052	NA	FT	CARBOHYDRATE METABOLISM			Xylulokinase, converts D-xylulose and ATP to xylulose 5-phosphate and ADP; rate limiting step in fermentation of xylulose; required for xylose fermentation by recombinant S. cerevisiae strains	xylulose catabolic process	xylulokinase activity	cytoplasm
YPL137C	YPL137C	GIP3	hom	Verified	0.427969269882801	0.334336746823403	no	1597	0.338918810327004	1167	NA	FT	CHROMOSOME SEGREGATION	ENDOPLASMIC RETICULUM|MITOCHONDRION		Cytoplasmic protein that regulates protein phosphatase 1 Glc7p; overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation; may interact with ribosomes, based on co-purification experiments; GIP3 has a paralog, HER1, that arose from the whole genome duplication	chromosome segregation|regulation of phosphoprotein phosphatase activity	protein phosphatase type 1 regulator activity|protein phosphatase 1 binding	mitochondrion|ribosome|endoplasmic reticulum|cytoplasm
YMR159C	YMR159C	ATG16	hom	Verified	0.427935215778897	0.334349143649214	no	1598	0.334003247689651	1131	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS			Conserved protein involved in autophagy; interacts with Atg12p-Atg5p conjugates to form Atg12p-Atg5p-Atg16p multimers, which localize to the pre-autophagosomal structure and are required for autophagy; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress	C-terminal protein lipidation|piecemeal microautophagy of nucleus|mitochondrion degradation|macroautophagy|CVT pathway	protein binding, bridging|Atg8 ligase activity	Atg12-Atg5-Atg16 complex|pre-autophagosomal structure
YLR283W_p	YLR283W	YLR283W	hom	Uncharacterized	0.427882885187188	0.334368194076223	no	1599	0.318674202866347	1087	NA	FT		MITOCHONDRION		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR283W is not an essential gene	biological_process	molecular_function	mitochondrion
YEL042W	YEL042W	GDA1	hom	Verified	0.427819249210029	0.334391360690161	no	1600	0.333160699145006	1117	NA	FT	CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Guanosine diphosphatase located in the Golgi, involved in the transport of GDP-mannose into the Golgi lumen by converting GDP to GMP after mannose is transferred its substrate	protein glycosylation	guanosine-diphosphatase activity|uridine-diphosphatase activity	Golgi apparatus
YML076C	YML076C	WAR1	hom	Verified	0.427769173839811	0.334409591022116	no	1601	0.310112988800878	1059	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS|MITOCHONDRION		Homodimeric Zn2Cys6 zinc finger transcription factor; binds to a weak acid response element to induce transcription of PDR12 and FUN34, encoding an acid transporter and a putative ammonia transporter, respectively	response to acid	sequence-specific DNA binding transcription factor activity	mitochondrion|nucleus
YIL110W	YIL110W	HPM1	hom	Verified	0.426771737169353	0.334772796987215	no	1602	0.326688376592962	1087	NA	FT		NUCLEUS		AdoMet-dependent methyltransferase involved in a novel 3-methylhistidine modification of ribosomal protein Rpl3p; seven beta-strand MTase family member; null mutant exhibits a weak vacuolar protein sorting defect and caspofungin resistance	peptidyl-histidine methylation, to form tele-methylhistidine	S-adenosylmethionine-dependent methyltransferase activity|protein-histidine N-methyltransferase activity	nucleus|cytoplasm
YIL133C	YIL133C	RPL16A	hom	Verified	0.426689080162205	0.334802902600654	no	1603	0.32716838700548	1119	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L16A; N-terminally acetylated, binds 5.8 S rRNA; transcriptionally regulated by Rap1p; homologous to mammalian ribosomal protein L13A and bacterial L13; RPL16A has a paralog, RPL16B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress	cytoplasmic translation	structural constituent of ribosome|RNA binding	cytosolic large ribosomal subunit
YCR024C	YCR024C	SLM5	hom	Verified	0.425389898013888	0.335276234491728	no	1604	0.34747331313241	1168	NA	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial asparaginyl-tRNA synthetase	asparaginyl-tRNA aminoacylation|mitochondrial asparaginyl-tRNA aminoacylation	asparagine-tRNA ligase activity	mitochondrion
YLR366W_d	YLR366W	YLR366W	hom	Dubious	0.425060025367309	0.335396458890894	no	1605	0.330588631963717	1106	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR364C-A	Unknown	Unknown	Unknown
YML052W	YML052W	SUR7	hom	Verified	0.42384311203755	0.335840117213841	no	1606	0.311884319135582	1074	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION	MITOCHONDRION|PLASMA MEMBRANE		Plasma membrane protein that localizes to furrow-like invaginations (MCC patches); component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants	endocytosis|ascospore formation	molecular_function	cell cortex|eisosome|mitochondrion|membrane raft|integral to membrane|plasma membrane|actin cortical patch
YBL002W	YBL002W	HTB2	hom	Verified	0.421223251280823	0.336796033685145	no	1607	0.321169334053896	1082	NA	FT	CHROMATIN ORGANIZATION	NUCLEUS|CHROMOSOME		Histone H2B, core histone protein required for chromatin assembly and chromosome function; nearly identical to HTB1; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation	chromatin assembly or disassembly	DNA binding	replication fork protection complex|nuclear nucleosome
YDR483W	YDR483W	KRE2	hom	Verified	0.421184073370746	0.336810336670388	no	1608	0.373220319712153	1216	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Alpha1,2-mannosyltransferase of the Golgi; involved in protein mannosylation; KRE2 has a paralog, KTR6, that arose from the whole genome duplication	N-glycan processing|cell wall mannoprotein biosynthetic process|protein O-linked glycosylation	alpha-1,2-mannosyltransferase activity	Golgi apparatus
YDL023C_d	YDL023C	YDL023C	hom	Dubious	0.420487097350318	0.337064826573399	no	1609	0.347120411453269	1153	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in other Saccharomyces species; overlaps the verified gene GPD1; deletion confers sensitivity to GSAO; deletion in cyr1 mutant results in loss of stress resistance	Unknown	Unknown	Unknown
YEL039C	YEL039C	CYC7	hom	Verified	0.420402310447028	0.337095790277422	no	1610	0.350583134396962	1143	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Cytochrome c isoform 2, expressed under hypoxic conditions; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration; protein abundance increases in response to DNA replication stress; CYC7 has a paralog, CYC1, that arose from the whole genome duplication	mitochondrial electron transport, cytochrome c to oxygen|mitochondrial electron transport, ubiquinol to cytochrome c	electron carrier activity	mitochondrion|mitochondrial intermembrane space
YLR072W_p	YLR072W	YLR072W	hom	Uncharacterized	0.420228414336849	0.337159299619651	no	1611	0.340644892909928	1138	NA	FT		ENDOMEMBRANE SYSTEM		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YLR072W is not an esssential gene	biological_process	molecular_function	cytoplasm
YJL053W	YJL053W	PEP8	hom	Verified	0.419094013252465	0.337573712912233	no	1612	0.353189614969016	1194	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM		Vacuolar protein component of the retromer; forms part of the multimeric membrane-associated retromer complex involved in vacuolar protein sorting along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport; interacts with Ypt7p; protein abundance increases in response to DNA replication stress	protein retention in Golgi apparatus|retrograde transport, endosome to Golgi	protein transporter activity	endosome|retromer complex, inner shell|retromer complex
YJL177W	YJL177W	RPL17B	hom	Verified	0.418976502255671	0.3376166526683	no	1613	0.310712160933658	1065	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L17B; homologous to mammalian ribosomal protein L17 and bacterial L22; RPL17B has a paralog, RPL17A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YLR297W	YLR297W	YLR297W	hom	Verified	0.417116431880705	0.338296623243527	no	1614	0.337631338063472	1137	NA					Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; not an essential gene; induced by treatment with 8-methoxypsoralen and UVA irradiation; relocalizes from nucleus to vacuole upon DNA replication stress; YLR297W has a paralog, YOR186W, that arose from the whole genome duplication	biological_process	molecular_function	fungal-type vacuole
YPL052W	YPL052W	OAZ1	hom	Verified	0.416908950943079	0.338372503091496	no	1615	0.332512830839288	1125	NA	FT	TRANSLATION|PROTEOLYSIS			Regulator of ornithine decarboxylase (Spe1p), antizyme that binds to Spe1p to stimulate ubiquitin-independent degradation by the proteasome; binding of polyamines to nascent Oaz1p during translation stimulates +1 ribosomal frameshifting, allowing translation of full-length Oaz1p	Unknown|regulation of proteasomal protein catabolic process	ornithine decarboxylase inhibitor activity	cytoplasm
YBL024W	YBL024W	NCL1	hom	Verified	0.416604255927769	0.33848394793115	no	1616	0.36287043224777	1205	NA	FT	RNA PROCESSING	NUCLEUS		S-adenosyl-L-methionine-dependent tRNA: m5C-methyltransferase, methylates cytosine to m5C at several positions in tRNAs and intron-containing pre-tRNAs; increases proportion of tRNALeu(CAA) with m5C at wobble position in response to hydrogen peroxide, causing selective translation of mRNA from genes enriched in TTG codon; loss of NCL1 confers hypersensitivity to oxidative stress; similar to Nop2p and human proliferation associated nucleolar protein p120	tRNA methylation	tRNA (cytosine-5-)-methyltransferase activity	nucleus
YOL068C	YOL068C	HST1	hom	Verified	0.416567328569748	0.338497455393397	no	1617	0.345308243200378	1179	NA	FT	CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS|CHROMOSOME		NAD(+)-dependent histone deacetylase; essential subunit of the Sum1p/Rfm1p/Hst1p complex required for ORC-dependent silencing and mitotic repression; non-essential subunit of the Set3C deacetylase complex; involved in telomere maintenance	chromatin silencing|negative regulation of mitotic recombination|histone deacetylation	NAD-independent histone deacetylase activity|NAD-dependent histone deacetylase activity	Set3 complex
YER175C	YER175C	TMT1	hom	Verified	0.416399147114866	0.338558976222817	no	1618	0.286748497376631	953	NA					Trans-aconitate methyltransferase, cytosolic enzyme that catalyzes the methyl esterification of 3-isopropylmalate, an intermediate of the leucine biosynthetic pathway, and trans-aconitate, which inhibits the citric acid cycle	biological_process	trans-aconitate 3-methyltransferase activity	cytosol
YER167W	YER167W	BCK2	hom	Verified	0.416353088951856	0.338575825065011	no	1619	0.368263518776839	1218	NA	FT	CELL CYCLE	NUCLEUS		Protein rich in serine and threonine residues involved in protein kinase C signaling pathway, which controls cell integrity; overproduction suppresses pkc1 mutations	regulation of cell cycle|positive regulation of gene expression|G1/S transition of mitotic cell cycle	molecular_function	nucleus|cytoplasm
YOR222W	YOR222W	ODC2	hom	Verified	0.415885505105067	0.338746893299439	no	1620	0.32500354241514	1104	NA	FT		MITOCHONDRION		Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for use in lysine and glutamate biosynthesis and in lysine catabolism	mitochondrial transport	dicarboxylic acid transmembrane transporter activity	mitochondrion|integral to membrane|mitochondrial inner membrane
YOR302W	YOR302W	YOR302W	hom	Verified	0.415248413061038	0.338980030621568	no	1621	0.32817264542322	1105	NA	FT	TRANSLATION			CPA1 uORF, Arginine attenuator peptide, regulates translation of the CPA1 mRNA	regulation of translation	translation regulator activity	cytosol
YDL131W	YDL131W	LYS21	hom	Verified	0.413934294328854	0.339461113695582	no	1622	0.314775434001367	1080	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS|MITOCHONDRION		Homocitrate synthase isozyme; catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; LYS21 has a paralog, LYS20, that arose from the whole genome duplication	lysine biosynthetic process via aminoadipic acid	homocitrate synthase activity	nucleus
YGR295C	YGR295C	COS6	hom	Verified	0.413338900321402	0.339679166492468	no	1623	0.326704674169828	1086	NA					Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins	biological_process	molecular_function	integral to membrane|fungal-type vacuole
YLR307C-A_p	YLR307C-A	YLR307C-A	hom	Uncharacterized	0.412827436680168	0.339866524095416	no	1624	0.325235795877577	1080	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YBL065W_d	YBL065W	YBL065W	hom	Dubious	0.412197302944846	0.340097406913453	no	1625	0.356057940850981	1166	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF SEF1/YBL066C; YBL065W is a non-essential gene	Unknown	Unknown	Unknown
YIL141W_d	YIL141W	YIL141W	hom	Dubious	0.411496519163581	0.340354246549765	no	1626	0.330983685908893	1123	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YCR066W	YCR066W	RAD18	hom	Verified	0.411299820114581	0.3404263507378	no	1627	0.357858038943272	1216	NA	FF|FT	RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		E3 ubiquitin ligase; forms heterodimer with Rad6p to monoubiquitinate PCNA-K164; heterodimer binds single-stranded DNA and has single-stranded DNA dependent ATPase activity; required for postreplication repair; SUMO-targeted ubiquitin ligase (STUbl) that contains a SUMO-interacting motif (SIM) which stimulates its ubiquitin ligase activity towards the sumoylated form of PCNA	protein monoubiquitination|error-free translesion synthesis|error-free postreplication DNA repair|error-prone translesion synthesis	ubiquitin-protein ligase activity|single-stranded DNA-dependent ATPase activity|single-stranded DNA binding	nuclear chromatin|nucleus
YPR194C	YPR194C	OPT2	hom	Verified	0.411200137582646	0.340462893701251	no	1628	0.329766694463395	1107	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION	PLASMA MEMBRANE		Oligopeptide transporter; member of the OPT family, with potential orthologs in S. pombe and C. albicans; also plays a role in formation of mature vacuoles	oligopeptide transport|vacuole fusion, non-autophagic	oligopeptide transporter activity	integral to membrane|integral to plasma membrane
YLR445W	YLR445W	GMC2	hom	Verified	0.410388939089517	0.340760329423774	no	1629	0.347188407178092	1144	NA	FT	CELL CYCLE			Protein involved in meiotic progression; mutants are delayed in meiotic nuclear division and are defective in synaptonemal complex assembly; transcription is regulated by Ume6p and induced in response to alpha factor	meiosis|synaptonemal complex organization	molecular_function	cellular_component
YER007C-A	YER007C-A	TMA20	hom	Verified	0.410108589033909	0.34086314619262	no	1630	0.327905883819713	1109	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION			Protein of unknown function that associates with ribosomes; has a putative RNA binding domain; interacts with Tma22p; null mutant exhibits translation defects; has homology to human oncogene MCT-1; protein abundance increases in response to DNA replication stress	ribosome biogenesis	RNA binding	ribosome|cytoplasm
YLR025W	YLR025W	SNF7	hom	Verified	0.4088922074671	0.341309383963799	no	1631	0.388998547676944	1300	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|PROTEOLYSIS|VACUOLAR TRANSPORT			One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; recruited from the cytoplasm to endosomal membranes	cellular response to anoxia|intralumenal vesicle formation|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|late endosome to vacuole transport	protein binding	ESCRT III complex|cytoplasm
YBR056W-A_p	YBR056W-A	YBR056W-A	hom	Uncharacterized	0.408827827778338	0.341333008276977	no	1632	0.372353525669313	1225	NA					Protein of unknown function; mRNA identified as translated by ribosome profiling data; partially overlaps the dubious ORF YBR056C-B	biological_process	molecular_function	cellular_component
YKL187C	YKL187C	FAT3	hom	Verified	0.408078666096277	0.34160796102127	no	1633	0.318835899945838	1043	NA	FT		MITOCHONDRION		Protein required for fatty acid uptake; Fat3p abundance increases in cortical patches in response to oleate exposure; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion|integral to membrane
YML024W	YML024W	RPS17A	hom	Verified	0.407603976696332	0.34178222214451	no	1634	0.325509393745767	1132	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Ribosomal protein 51 (rp51) of the small (40s) subunit; homologous to mammalian ribosomal protein S17, no bacterial homolog; RPS17A has a paralog, RPS17B, that arose from the whole genome duplication	cytoplasmic translation|ribosomal small subunit assembly	structural constituent of ribosome	cytosolic small ribosomal subunit
YPL035C_d	YPL035C	YPL035C	hom	Dubious	0.407555782461699	0.34179991640265	no	1635	0.346270900528923	1156	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YPL034W; YPL035C is not an essential gene	Unknown	Unknown	Unknown
YEL059C-A	YEL059C-A	SOM1	hom	Verified	0.407548020776938	0.34180276609662	no	1636	0.332670146870258	1101	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs	proteolysis|mitochondrial respiratory chain complex assembly	endopeptidase activity	mitochondrial inner membrane peptidase complex|mitochondrial inner membrane
YGR243W	YGR243W	FMP43	hom	Verified	0.407470202944646	0.341831337325841	no	1637	0.340892635181927	1157	NA	FT		MITOCHONDRION		Highly conserved subunit of the mitochondrial pyruvate carrier; a mitochondrial inner membrane complex comprised of Fmp37p/Mpc1p and either Mpc2p or Fmp43p/Mpc3p mediates mitochondrial pyruvate uptake; more highly expressed in glucose-containing minimal medium than in lactate-containing medium; expression regulated by osmotic and alkaline stresses; protein abundance increases in response to DNA replication stress	mitochondrial pyruvate transport	pyruvate transmembrane transporter activity	mitochondrion|mitochondrial membrane
YML081C-A	YML081C-A	ATP18	hom	Verified	0.407227448893298	0.341920471581903	no	1638	0.330331923651023	1099	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS	MITOCHONDRION		Subunit of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; termed subunit I or subunit j; does not correspond to known ATP synthase subunits in other organisms	mitochondrial proton-transporting ATP synthase complex assembly|ATP synthesis coupled proton transport	hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism	mitochondrion|mitochondrial proton-transporting ATP synthase complex|mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
YER119C-A_d	YER119C-A	YER119C-A	hom	Dubious	0.406242916795428	0.342282061656429	no	1639	0.366418777962371	1251	NA	FF				Dubious open reading frame, not conserved in closely related Saccharomyces species; deletion mutation blocks replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene SCS2	Unknown	Unknown	Unknown
YNL339C	YNL339C	YRF1-6	hom	Verified	0.405467004510295	0.342567133662281	no	1640	0.326164038229574	1100	NA	FT		NUCLEUS		Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p	telomere maintenance via recombination	DNA helicase activity	nucleus
YOR097C_p	YOR097C	YOR097C	hom	Uncharacterized	0.404217256479811	0.343026482571197	no	1641	0.356517193674856	1198	NA					Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen; YOR097C is not an essential gene	biological_process	molecular_function	cellular_component
YHL028W	YHL028W	WSC4	hom	Verified	0.40383245069837	0.343167965938369	no	1642	0.331721030343883	1103	NA	FT	PROTEIN LOCALIZATION|CELL WALL ORG/BIOGENESIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		ER membrane protein involved in the translocation of soluble secretory proteins and insertion of membrane proteins into the ER membrane; may also have a role in the stress response but has only partial functional overlap with WSC1-3	response to heat|SRP-dependent cotranslational protein targeting to membrane, translocation|protein targeting to ER|response to stress	transmembrane signaling receptor activity	endoplasmic reticulum membrane
YBR033W_p	YBR033W	EDS1	hom	Uncharacterized	0.403783476982145	0.343185973914561	no	1643	0.333006215119518	1122	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Putative zinc cluster protein, predicted to be a transcription factor; not an essential gene; EDS1 has a paralog, RGT1, that arose from the whole genome duplication	biological_process	sequence-specific DNA binding	cellular_component
YCR003W	YCR003W	MRPL32	hom	Verified	0.402424528803972	0.343685810524491	no	1644	0.355424072361342	1190	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial inner membrane|mitochondrial large ribosomal subunit
YKR055W	YKR055W	RHO4	hom	Verified	0.402400128794161	0.343694787626912	no	1645	0.337280595559962	1157	NA	FT	SIGNALING|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely to be involved in the establishment of cell polarity	positive regulation of formin-nucleated actin cable assembly|maintenance of cell polarity|regulation of formin-nucleated actin cable assembly	GTPase activity	incipient cellular bud site|plasma membrane|cellular bud neck
YBR205W	YBR205W	KTR3	hom	Verified	0.402063220978088	0.343818749699527	no	1646	0.316911264616469	1053	NA	FT	CARBOHYDRATE METABOLISM			Putative alpha-1,2-mannosyltransferase; involved in O- and N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; Svp26p mediates uptake of Ktr3p into COPII vesicles; relocalizes from nucleus to vacuole upon DNA replication stress	N-glycan processing|protein O-linked glycosylation	mannosyltransferase activity	fungal-type vacuole
YOL092W	YOL092W	YPQ1	hom	Verified	0.401113627115938	0.344168234189796	no	1647	0.336572180993243	1114	NA					Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; member of the PQ-loop family, with seven transmembrane domains; similar to mammalian PQLC2 vacuolar transporter	biological_process	molecular_function	fungal-type vacuole membrane|integral to membrane|cytoplasm
YFL048C	YFL048C	EMP47	hom	Verified	0.399673146634528	0.344698636591326	no	1648	0.34337258399058	1151	NA	FT	VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport	ER to Golgi vesicle-mediated transport	glycoprotein binding	fungal-type vacuole membrane|integral to endoplasmic reticulum membrane|integral to Golgi membrane|ER to Golgi transport vesicle
YMR322C_p	YMR322C	SNO4	hom	Uncharacterized	0.399088981610545	0.344913820350277	no	1649	0.319473740105078	1036	NA	FT	PROTEOLYSIS			Possible chaperone and cysteine protease, similar to bacterial Hsp31 and yeast Hsp31p, Hsp32p, and Hsp33p; DJ-1/ThiJ/PfpI superfamily member; predicted involvement in pyridoxine metabolism; induced by mild heat stress and copper deprivation	biological_process	cysteine-type peptidase activity	cellular_component
YKL140W	YKL140W	TGL1	hom	Verified	0.398998787543824	0.344947048822363	no	1650	0.307730737754516	1053	NA	FT	LIPID METABOLISM			Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes	cellular lipid metabolic process|sterol metabolic process	lipase activity|sterol esterase activity	integral to membrane|lipid particle
YIL074C	YIL074C	SER33	hom	Verified	0.396769332886046	0.345768783623181	no	1651	0.330433314388502	1137	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS			3-phosphoglycerate dehydrogenase; catalyzes the first step in serine and glycine biosynthesis; SER33 has a paralog, SER3, that arose from the whole genome duplication	serine family amino acid biosynthetic process	phosphoglycerate dehydrogenase activity	cytoplasm
YDR191W	YDR191W	HST4	hom	Verified	0.396443251758238	0.345889031998282	no	1652	0.34659021742669	1177	NA	FT	KETONE METABOLISM|LIPID METABOLISM|CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS		Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst3p in silencing at telomeres, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism	short-chain fatty acid metabolic process|chromatin silencing at telomere|histone deacetylation	histone deacetylase activity|DNA binding	nucleus|cytoplasm
YKL101W	YKL101W	HSL1	hom	Verified	0.395744251569529	0.346146853458776	no	1653	0.354334011530644	1164	NA	FT	CELL CYCLE|CELL DIVISION|PROTEIN PHOSPHORYLATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Nim1p-related protein kinase that regulates the morphogenesis and septin checkpoints; associates with the assembled septin filament; required along with Hsl7p for bud neck recruitment, phosphorylation, and degradation of Swe1p	G2/M transition of mitotic cell cycle|regulation of cell cycle|cell shape checkpoint|protein autophosphorylation|protein phosphorylation|septin checkpoint	protein kinase activity	cellular bud neck|septin ring
YML095C	YML095C	RAD10	hom	Verified	0.395714758490677	0.346157733349165	no	1654	0.338262860238297	1101	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS		Single-stranded DNA endonuclease (with Rad1p), cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human ERCC1 protein	mitotic recombination|meiotic mismatch repair|DNA strand renaturation|nucleotide-excision repair, DNA incision, 5'-to lesion|removal of nonhomologous ends|double-strand break repair via single-strand annealing, removal of nonhomologous ends	single-stranded DNA binding|single-stranded DNA specific endodeoxyribonuclease activity	nucleotide-excision repair factor 1 complex|nucleus
YBR255W	YBR255W	MTC4	hom	Verified	0.395609092302302	0.346196714267213	no	1655	0.36278039891017	1205	NA					Protein of unknown function, required for normal growth rate at 15 degrees C; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; mtc4 is synthetically sick with cdc13-1	biological_process	molecular_function	cytoplasm
YKL162C-A_d	YKL162C-A	YKL162C-A	hom	Dubious	0.395167575480668	0.34635961021064	no	1656	0.340335894024646	1140	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YJL067W_d	YJL067W	YJL067W	hom	Dubious	0.393170868884967	0.347096642010317	no	1657	0.331907639057328	1112	NA					Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YML032C	YML032C	RAD52	hom	Verified	0.39264711898844	0.347290066459368	no	1658	0.351291139343802	1132	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Protein that stimulates strand exchange by facilitating Rad51p binding to single-stranded DNA; anneals complementary single-stranded DNA; involved in the repair of double-strand breaks in DNA during vegetative growth and meiosis	postreplication repair|telomere maintenance via recombination|meiotic joint molecule formation|meiotic DNA recombinase assembly|DNA recombinase assembly|DNA strand renaturation|double-strand break repair via synthesis-dependent strand annealing|double-strand break repair via single-strand annealing|double-strand break repair via break-induced replication	recombinase activity	nuclear chromosome|nucleus
YPR008W	YPR008W	HAA1	hom	Verified	0.392362739588679	0.347395106400069	no	1659	0.337509819233415	1137	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Transcriptional activator involved in adaptation to weak acid stress; activates transcription of TPO2, YRO2, and other genes encoding membrane stress proteins; HAA1 has a paralog, CUP2, that arose from the whole genome duplication; relocalizes from cytoplasm to nucleus upon DNA replication stress	response to acid|positive regulation of transcription from RNA polymerase II promoter in response to stress|positive regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding RNA polymerase II transcription factor activity	nucleus
YOR316C	YOR316C	COT1	hom	Verified	0.392150446538674	0.347473527771054	no	1660	0.359790166643177	1177	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Vacuolar transporter that mediates zinc transport into the vacuole; overexpression confers resistance to cobalt and rhodium; protein abundance increases in response to DNA replication stress; COT1 has a paralog, ZRC1, that arose from the whole genome duplication	cellular zinc ion homeostasis|cobalt ion transport|zinc ion transport	cobalt ion transmembrane transporter activity|zinc ion transmembrane transporter activity|inorganic cation transmembrane transporter activity	mitochondrion|integral to membrane|fungal-type vacuole
YLR413W_p	YLR413W	YLR413W	hom	Uncharacterized	0.392145853917127	0.3474752243645	no	1661	0.333083904249747	1123	NA	FT		PLASMA MEMBRANE		Putative protein of unknown function; YLR413W is not an essential gene	biological_process	molecular_function	integral to membrane
YHR117W	YHR117W	TOM71	hom	Verified	0.391796739660947	0.347604202121608	no	1662	0.342209731190864	1136	NA	FT		MITOCHONDRION		Mitochondrial outer membrane protein; probable minor component of the TOM (translocase of outer membrane) complex responsible for recognition and import of mitochondrially directed proteins; TOM71 has a paralog, TOM70, that arose from the whole genome duplication	biological_process	protein transporter activity	mitochondrial outer membrane|mitochondrion|integral to membrane|integral to mitochondrial outer membrane
YER046W-A_d	YER046W-A	YER046W-A	hom	Dubious	0.391332346512884	0.347775796179505	no	1663	0.341542510631707	1167	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YFL030W	YFL030W	AGX1	hom	Verified	0.391208685848565	0.347821494264541	no	1664	0.343973711318184	1146	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		Alanine:glyoxylate aminotransferase (AGT), catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast; has similarity to mammalian and plant alanine:glyoxylate aminotransferases	glycine biosynthetic process, by transamination of glyoxylate	alanine-glyoxylate transaminase activity	mitochondrion
YMR048W	YMR048W	CSM3	hom	Verified	0.389921751892606	0.348297204396958	no	1665	0.325952480826235	1083	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME		Replication fork associated factor; required for stable replication fork pausing; component of the DNA replication checkpoint pathway; required for accurate chromosome segregation during meiosis; forms nuclear foci upon DNA replication stress	DNA repair|DNA replication checkpoint|meiotic chromosome segregation|maintenance of DNA repeat elements|replication fork arrest|replication fork protection|mitotic sister chromatid cohesion|establishment of mitotic sister chromatid cohesion	molecular_function	replication fork protection complex|nucleus
YLR227C	YLR227C	ADY4	hom	Verified	0.389703840402289	0.348377778188505	no	1666	0.327029456674643	1079	NA	FT	CELL CYCLE|CELL DIVISION	NUCLEUS|CYTOSKELETON		Structural component of the meiotic outer plaque, which is a membrane-organizing center that assembles on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane	sporulation resulting in formation of a cellular spore	structural molecule activity	spindle pole body
YBR116C_d	YBR116C	YBR116C	hom	Dubious	0.38928726502737	0.348531827920497	no	1667	0.333973750792105	1091	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene TKL2	Unknown	Unknown	Unknown
YER047C	YER047C	SAP1	hom	Verified	0.387999550086815	0.349008183276413	no	1668	0.367905436969851	1208	NA					Putative ATPase of the AAA family, interacts with the Sin1p transcriptional repressor in the two-hybrid system	biological_process	ATPase activity	cytoplasm
YHR113W	YHR113W	APE4	hom	Verified	0.387696513032222	0.349120318276816	no	1669	0.341572345099025	1174	NA	FT	PROTEOLYSIS			Cytoplasmic aspartyl aminopeptidase that may also function in the vacuole; CVT pathway cargo protein; cleaves unblocked N-terminal acidic amino acids from peptide substrates; forms a 12-subunit homo-oligomer; M18 metalloprotease family	proteolysis	aminopeptidase activity	fungal-type vacuole lumen|ribosome|cytoplasm
YPL165C	YPL165C	SET6	hom	Verified	0.387523759648463	0.349184249361853	no	1670	0.337055132521747	1110	NA					SET domain protein of unknown function; deletion heterozygote is sensitive to compounds that target ergosterol biosynthesis, may be involved in compound availability	biological_process	molecular_function	cellular_component
YKL026C	YKL026C	GPX1	hom	Verified	0.387498336008498	0.349193658284992	no	1671	0.354144269575673	1155	NA	FT	OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS			Phospholipid hydroperoxide glutathione peroxidase induced by glucose starvation that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress	cellular response to oxidative stress|peroxisome organization	phospholipid-hydroperoxide glutathione peroxidase activity|glutathione peroxidase activity	extrinsic to mitochondrial outer membrane|peroxisomal matrix
YBL061C	YBL061C	SKT5	hom	Verified	0.386116863651632	0.349705060540951	no	1672	0.357136724504704	1192	NA	FT	CELL WALL ORG/BIOGENESIS|CELL DIVISION|CARBOHYDRATE METABOLISM	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON		Activator of Chs3p (chitin synthase III) during vegetative growth; recruits Chs3p to the bud neck via interaction with Bni4p; SKT5 has a paralog, SHC1, that arose from the whole genome duplication	fungal-type cell wall chitin biosynthetic process|response to osmotic stress|cytokinesis	enzyme activator activity	incipient cellular bud site|cellular bud neck septin ring|cellular bud neck
YOL050C_d	YOL050C	YOL050C	hom	Dubious	0.385202041033824	0.350043865641253	no	1673	0.361503776289098	1191	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps verified gene GAL11; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)	Unknown	Unknown	Unknown
YDR265W	YDR265W	PEX10	hom	Verified	0.385153431444865	0.350061871574665	no	1674	0.348608633100293	1159	NA	FT	PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION			Peroxisomal membrane E3 ubiquitin ligase, required for for Ubc4p-dependent Pex5p ubiquitination and peroxisomal matrix protein import; contains zinc-binding RING domain; mutations in human homolog cause various peroxisomal disorders	protein import into peroxisome matrix|protein ubiquitination	ubiquitin-protein ligase activity|protein binding	peroxisomal membrane
YGR088W	YGR088W	CTT1	hom	Verified	0.385059696986926	0.350096593585459	no	1675	0.310297849585986	1046	NA	FT	OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS			Cytosolic catalase T, has a role in protection from oxidative damage by hydrogen peroxide	response to reactive oxygen species	catalase activity	cytoplasm
YLR382C	YLR382C	NAM2	hom	Verified	0.384722824151485	0.350221391573929	no	1676	0.369492818348309	1191	NA	FT	KETONE METABOLISM|RNA PROCESSING|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial leucyl-tRNA synthetase, also has a direct role in splicing of several mitochondrial group I introns; indirectly required for mitochondrial genome maintenance	Group I intron splicing|leucyl-tRNA aminoacylation|mitochondrial translation	mRNA binding|leucine-tRNA ligase activity	mitochondrion
YBR162C	YBR162C	TOS1	hom	Verified	0.384524626475428	0.350294823489411	no	1677	0.320375887083952	1064	NA					Covalently-bound cell wall protein of unknown function; identified as a cell cycle regulated SBF target gene; deletion mutants are highly resistant to treatment with beta-1,3-glucanase; has sequence similarity to YJL171C	biological_process	molecular_function	fungal-type cell wall|fungal-type vacuole
YDR529C	YDR529C	QCR7	hom	Verified	0.38449190046684	0.350306948960586	no	1678	0.368673041966794	1194	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Subunit 7 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the mitochondrial matrix; N-terminus appears to play a role in complex assembly	mitochondrial electron transport, ubiquinol to cytochrome c|aerobic respiration|mitochondrial respiratory chain complex III assembly	ubiquinol-cytochrome-c reductase activity	mitochondrion|integral to membrane|mitochondrial respiratory chain complex III
YHL029C_p	YHL029C	OCA5	hom	Uncharacterized	0.384368759315789	0.350352575949059	no	1679	0.364729955890936	1256	NA	FT	SIGNALING|NUCLEOTIDE METABOLISM			Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts	biological_process	molecular_function	cytoplasm
YOL084W	YOL084W	PHM7	hom	Verified	0.383714241571434	0.350595127971001	no	1680	0.315906386197858	1068	NA	FT		PLASMA MEMBRANE		Protein of unknown function; expression is regulated by phosphate levels; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	integral to membrane|fungal-type vacuole
YJR148W	YJR148W	BAT2	hom	Verified	0.383541278286637	0.350659235106887	no	1681	0.341324574245891	1153	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Cytosolic branched-chain amino acid (BCAA) aminotransferase, preferentially involved in BCAA catabolism; homolog of murine ECA39; highly expressed during stationary phase and repressed during logarithmic phase	branched-chain amino acid catabolic process|branched-chain amino acid biosynthetic process	branched-chain-amino-acid transaminase activity	nucleus|cytoplasm
YLL048C	YLL048C	YBT1	hom	Verified	0.383124664140399	0.350813666487904	no	1682	0.352493136452366	1172	NA	FT	NUCLEOTIDE METABOLISM			Transporter of the ATP-binding cassette (ABC) family; involved in bile acid transport; negative regulator of vacuole fusion; regulates the release of lumenal Ca2+ stores; similar to mammalian bile transporters	bile acid and bile salt transport	bile acid-exporting ATPase activity	integral to membrane|fungal-type vacuole
YLR456W_p	YLR456W	YLR456W	hom	Uncharacterized	0.382880656520525	0.350904127178616	no	1683	0.326208568094177	1126	NA	FT	OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM	NUCLEUS		Putative pyridoxal 5'-phosphate synthase; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2; YLR456W has a paralog, YPR172W, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YBR045C	YBR045C	GIP1	hom	Verified	0.382545102457033	0.351028540589024	no	1684	0.360785451124954	1206	NA	FT	CELL WALL ORG/BIOGENESIS			Meiosis-specific regulatory subunit of the Glc7p protein phosphatase, regulates spore wall formation and septin organization, required for expression of some late meiotic genes and for normal localization of Glc7p	ascospore wall assembly|regulation of phosphoprotein phosphatase activity	protein phosphatase type 1 regulator activity|protein phosphatase 1 binding	protein phosphatase type 1 complex|prospore membrane
YJL210W	YJL210W	PEX2	hom	Verified	0.382095947310137	0.351195098878408	no	1685	0.344079952460207	1152	NA	FT	PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION			RING-finger peroxin and E3 ubiquitin ligase, peroxisomal membrane protein with a C-terminal zinc-binding RING domain, forms translocation subcomplex with Pex10p and Pex12p which functions in peroxisomal matrix protein import	protein import into peroxisome matrix	ubiquitin-protein ligase activity|protein binding	peroxisomal membrane
YOR271C_p	YOR271C	FSF1	hom	Uncharacterized	0.381893838445743	0.351270055375099	no	1686	0.336206539380408	1132	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Putative protein, predicted to be an alpha-isopropylmalate carrier; belongs to the sideroblastic-associated protein family; non-tagged protein is detected in purified mitochondria; likely to play a role in iron homeostasis	biological_process	molecular_function	mitochondrion|integral to membrane
YMR157C	YMR157C	AIM36	hom	Verified	0.381702473709492	0.351341032509212	no	1687	0.33643572431626	1133	NA	FT		MITOCHONDRION		Protein of unknown function; null mutant displays reduced respiratory growth and elevated frequency of mitochondrial genome loss; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YKL039W	YKL039W	PTM1	hom	Verified	0.38114567124932	0.351547579887656	no	1688	0.340749482759621	1157	NA	FT		ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Protein of unknown function; copurifies with late Golgi vesicles containing the v-SNARE Tlg2p; PTM1 has a paralog, YHL017W, that arose from the whole genome duplication	biological_process	molecular_function	integral to membrane
YHR039C	YHR039C	MSC7	hom	Verified	0.380759171169341	0.351690978917509	no	1689	0.366452293982201	1238	NA	FT	CELL CYCLE|OXIDATION-REDUCTION PROCESS	ENDOPLASMIC RETICULUM		Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; msc7 mutants are defective in directing meiotic recombination events to homologous chromatids	reciprocal meiotic recombination	molecular_function	integral to membrane|endoplasmic reticulum
YDR409W	YDR409W	SIZ1	hom	Verified	0.380185685283091	0.351903792194451	no	1690	0.349515585161597	1141	NA	FT	CHROMOSOME SEGREGATION	NUCLEUS|SITE OF POLARIZED GROWTH|CHROMOSOME|CYTOSKELETON		SUMO/Smt3 ligase that promotes the attachment of sumo (Smt3p; small ubiquitin-related modifier) to proteins; binds Ubc9p and may bind septins; specifically required for sumoylation of septins in vivo; localized to the septin ring	protein sumoylation|chromosome segregation	SUMO ligase activity	nuclear chromatin|septin ring
YIL067C_p	YIL067C	YIL067C	hom	Uncharacterized	0.380033493431128	0.351960276438052	no	1691	0.356401254621558	1187	NA					Uncharacterized protein of unknown function	biological_process	molecular_function	integral to membrane|fungal-type vacuole
YDR233C	YDR233C	RTN1	hom	Verified	0.379314371355024	0.352227214440309	no	1692	0.341397760231861	1146	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION|GOLGI APPARATUS		Reticulon protein; stabilizes membrane curvature; involved in nuclear pore assembly and maintenance of tubular ER morphology; mutant overexpressing RTN1 shows increase in tubular ER; interacts with exocyst subunit Sec6p, Yip3p, and Sbh1p; more abundant than Rtn2p; member of the RTNLA subfamily; mutants have reduced phosphatidylserine transfer between the ER and mitochondria; RTN1 has a paralog, RTN2, that arose from the whole genome duplication	endoplasmic reticulum tubular network organization|endoplasmic reticulum organization|endoplasmic reticulum tubular network maintenance|nuclear pore complex assembly	molecular_function	integral to endoplasmic reticulum membrane|mitochondrion|Golgi apparatus|endoplasmic reticulum|cortical endoplasmic reticulum|endoplasmic reticulum tubular network
YGR171C	YGR171C	MSM1	hom	Verified	0.378988638221016	0.352348150499563	no	1693	0.35825242509361	1179	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION	MITOCHONDRION		Mitochondrial methionyl-tRNA synthetase (MetRS), functions as a monomer in mitochondrial protein synthesis; functions similarly to cytoplasmic MetRS although the cytoplasmic form contains a zinc-binding domain not found in Msm1p	methionyl-tRNA aminoacylation	methionine-tRNA ligase activity	mitochondrion
YML009W-B_d	YML009W-B	YML009W-B	hom	Dubious	0.378246496629751	0.352623743699378	no	1694	0.35726309711011	1207	NA					Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion mutation confers an increase in Ty1 transposition	Unknown	Unknown	Unknown
YOR037W	YOR037W	CYC2	hom	Verified	0.377990109129274	0.352718970813431	no	1695	0.320603760571038	1083	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)	cytochrome c-heme linkage|mitochondrial membrane organization	oxidoreductase activity	extrinsic to mitochondrial inner membrane|mitochondrion
YLR419W_p	YLR419W	YLR419W	hom	Uncharacterized	0.377290789688617	0.352978758038097	no	1696	0.353685930228217	1176	NA	FT		MITOCHONDRION		Putative helicase with limited sequence similarity to human Rb protein; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YLR419W is not an essential gene	biological_process	molecular_function	mitochondrion|cytoplasm
YJL077C	YJL077C	ICS3	hom	Verified	0.377132960023505	0.353037398999311	no	1697	0.357555270956906	1227	NA					Protein of unknown function; may play a role in vacuolar sorting, null mutants are hypersensitive to sortin2	biological_process	molecular_function	cellular_component
YFR040W	YFR040W	SAP155	hom	Verified	0.376668842934394	0.353209860009311	no	1698	0.359938377299049	1195	NA	FT	CELL CYCLE			Protein required for function of the Sit4p protein phosphatase; forms a complex with Sit4p; member of a family of similar proteins including Sap4p, Sap185p, and Sap190p; protein abundance increases in response to DNA replication stress	G1/S transition of mitotic cell cycle	protein serine/threonine phosphatase activity	cytoplasm
YOR368W	YOR368W	RAD17	hom	Verified	0.375568612966824	0.353618814251747	no	1699	0.35787396607001	1186	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Checkpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints; with Mec3p and Ddc1p, forms a clamp that is loaded onto partial duplex DNA; homolog of human and S. pombe Rad1 and U. maydis Rec1 proteins	double-strand break repair|reciprocal meiotic recombination|DNA damage checkpoint	double-stranded DNA binding	nucleus|checkpoint clamp complex
YJL164C	YJL164C	TPK1	hom	Verified	0.375138526432148	0.353778722905939	no	1700	0.344862953625496	1153	NA	FT	CELL CYCLE|SIGNALING|CELL DIVISION|PROTEIN PHOSPHORYLATION	NUCLEUS		cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; regulates Whi3p; partially redundant with Tpk2p and Tpk3p; TPK1 has a paralog, TPK3, that arose from the whole genome duplication	protein phosphorylation|Ras protein signal transduction	cAMP-dependent protein kinase activity|protein kinase activity	cAMP-dependent protein kinase complex|nucleus|cytoplasm
YFR024C-A	YFR024C-A	LSB3	hom	Verified	0.37423569758519	0.354114483778857	no	1701	0.335363947829414	1139	NA	FT		MITOCHONDRION|SITE OF POLARIZED GROWTH		Protein containing a C-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein abundance increases in response to DNA replication stress; LSB3 has a paralog, YSC84, that arose from the whole genome duplication	actin cortical patch localization	molecular_function	mitochondrion|cellular bud neck|cytoplasm
YOR082C_d	YOR082C	YOR082C	hom	Dubious	0.374010399250237	0.354198289635581	no	1702	0.351711905263624	1155	NA					Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene YOR083W	Unknown	Unknown	Unknown
YFR017C	YFR017C	IGD1	hom	Verified	0.373186340199681	0.35450488098827	no	1703	0.364692921689226	1204	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY			Cytoplasmic protein that inhibits Gdb1p glycogen debranching activity; required for normal intracellular accumulation of glycogen; phosphorylated in vivo; expression increases during wine fermentation; protein abundance increases in response to DNA replication stress; IGD1 has a paralog, YOL024W, that arose from the whole genome duplication	negative regulation of glycogen catabolic process	enzyme inhibitor activity	cytoplasm
YER185W	YER185W	PUG1	hom	Verified	0.373036175257146	0.354560760051346	no	1704	0.339024740203934	1125	NA	FT		PLASMA MEMBRANE		Plasma membrane protein with roles in the uptake of protoprophyrin IX and the efflux of heme; expression is induced under both low-heme and low-oxygen conditions; member of the fungal lipid-translocating exporter (LTE) family of proteins	heme transport	molecular_function	integral to membrane|plasma membrane
YBR099C_d	YBR099C	YBR099C	hom	Dubious	0.373035942637061	0.354560846615872	no	1705	0.348970527712384	1151	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene MMS4	Unknown	Unknown	Unknown
YLR313C	YLR313C	SPH1	hom	Verified	0.373025621967564	0.354564687237041	no	1706	0.37914581728352	1260	NA	FT	CELL CYCLE|SIGNALING|CELL DIVISION|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Protein involved in shmoo formation and bipolar bud site selection; homologous to Spa2p, localizes to sites of polarized growth in a cell cycle dependent- and Spa2p-dependent manner, interacts with MAPKKs Mkk1p, Mkk2p, and Ste7p	bipolar cellular bud site selection|pseudohyphal growth|invasive filamentous growth|mating projection assembly	molecular_function	incipient cellular bud site|cellular bud neck|cellular bud tip|mating projection
YBR204C	YBR204C	LDH1	hom	Verified	0.372909079871954	0.354608056965089	no	1707	0.354047857284239	1149	NA	FT	LIPID METABOLISM			Serine hydrolase; exhibits active esterase plus weak triacylglycerol lipase activities; proposed role in lipid homeostasis, regulating phospholipid and non-polar lipid levels and required for mobilization of LD-stored lipids; localizes to the lipid droplet (LD) surface; contains a classical serine containing catalytic triad (GxSxG motif)	lipid homeostasis	hydrolase activity, acting on ester bonds|serine hydrolase activity|triglyceride lipase activity	lipid particle
YHR015W	YHR015W	MIP6	hom	Verified	0.371707610043356	0.355055279184638	no	1708	0.330151814567472	1068	NA	FT	RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	Putative RNA-binding protein; interacts with Mex67p, which is a component of the nuclear pore involved in nuclear mRNA export; MIP6 has a paralog, PES4, that arose from the whole genome duplication	mRNA export from nucleus	RNA binding	nuclear pore
YDR084C	YDR084C	TVP23	hom	Verified	0.371614076361393	0.355090103546021	no	1709	0.322348522001776	1100	NA	FT	VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern	vesicle-mediated transport	molecular_function	integral to membrane|integral to Golgi membrane|cytoplasm
YLR067C	YLR067C	PET309	hom	Verified	0.371523992623072	0.35512364457236	no	1710	0.359345465091285	1201	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Specific translational activator for the COX1 mRNA, also influences stability of intron-containing COX1 primary transcripts; localizes to the mitochondrial inner membrane; contains seven pentatricopeptide repeats (PPRs)	positive regulation of mitochondrial translational initiation|RNA metabolic process|mitochondrial respiratory chain complex IV biogenesis|aerobic respiration	translation regulator activity	extrinsic to mitochondrial inner membrane|mitochondrion|integral to membrane|mitochondrial inner membrane
YAL011W	YAL011W	SWC3	hom	Verified	0.370866963033479	0.355368311416376	no	1711	0.387795806767459	1288	NA	FF|FT	CHROMATIN ORGANIZATION	NUCLEUS|MITOCHONDRION|CHROMOSOME		Protein of unknown function, component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for formation of nuclear-associated array of smooth endoplasmic reticulum known as karmellae	endoplasmic reticulum organization|chromatin remodeling|histone exchange	molecular_function	mitochondrion|Swr1 complex|nucleus
YNL108C_p	YNL108C	YNL108C	hom	Uncharacterized	0.370116579749928	0.355647814546333	no	1712	0.368832625234601	1232	NA	FT		NUCLEUS		Putative protein of unknown function; similar to prokaryotic phosphotransfer enzymes; null mutant shows alterations in glucose metabolism; GFP-fusion protein localizes to the cytoplasm and nucleus; YNL108C has a paralog, TFC7, that arose from the whole genome duplication	biological_process	molecular_function	nucleus|cytoplasm
YIL002C	YIL002C	INP51	hom	Verified	0.369325732709062	0.355942473663245	no	1713	0.387552868192334	1288	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|MEMBRANE ORGANIZATION	CYTOSKELETON		Phosphatidylinositol 4,5-bisphosphate 5-phosphatase, synaptojanin-like protein with an N-terminal Sac1 domain, plays a role in phosphatidylinositol 4,5-bisphosphate homeostasis and in endocytosis; null mutation confers cold-tolerant growth	phosphatidylinositol dephosphorylation	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	membrane|cytoplasm
YOR094W	YOR094W	ARF3	hom	Verified	0.368650424058568	0.356194152846905	no	1714	0.337888535580062	1143	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL CYCLE|LIPID METABOLISM|MEMBRANE ORGANIZATION|SIGNALING|CELL DIVISION|CYTOSKELETON ORGANIZATION	GOLGI APPARATUS|SITE OF POLARIZED GROWTH		Glucose-repressible ADP-ribosylation factor, GTPase of the Ras superfamily involved in development of polarity; also has mRNA binding activity	intracellular protein transport|positive regulation of phosphatidylinositol biosynthetic process|endocytosis|actin filament bundle assembly|actin cortical patch localization|cellular bud site selection	mRNA binding|GTPase activity	cellular bud neck|cellular bud tip
YCR030C	YCR030C	SYP1	hom	Verified	0.368628734046456	0.356202237485411	no	1715	0.338921973024121	1092	NA	FT	CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH		Protein of unknown function that is involved in endocytic site formation; may regulate assembly and disassembly of the septin ring; colocalizes and interacts with septin subunits; potential role in actin cytoskeletal organization	septin cytoskeleton organization|actin cortical patch assembly	molecular_function	mating projection base|mating projection tip|cellular bud neck|cellular bud tip
YMR191W	YMR191W	SPG5	hom	Verified	0.368022300026797	0.356428303158077	no	1716	0.364084030365728	1185	NA					Protein required for proteasome assembly during quiescence; binds to base of the proteasome regulartory particle; required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources	biological_process	molecular_function	cellular_component
YJL063C	YJL063C	MRPL8	hom	Verified	0.367953653505628	0.356453896298085	no	1717	0.369401403121856	1271	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit	mitochondrial genome maintenance|mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YBR145W	YBR145W	ADH5	hom	Verified	0.367892089030116	0.356476849624206	no	1718	0.356827003283976	1174	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	NUCLEUS		Alcohol dehydrogenase isoenzyme V; involved in ethanol production; ADH5 has a paralog, ADH1, that arose from the whole genome duplication	NADH oxidation|ethanol biosynthetic process involved in glucose fermentation to ethanol|amino acid catabolic process to alcohol via Ehrlich pathway	alcohol dehydrogenase (NAD) activity	nucleus|cytoplasm
YGR227W	YGR227W	DIE2	hom	Verified	0.367506487442377	0.35662062680685	no	1719	0.355750770976198	1193	NA	FT	CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Dolichyl-phosphoglucose-dependent alpha-1,2 glucosyltransferase of the ER, functions in the pathway that synthesizes the dolichol-linked oligosaccharide precursor for N-linked protein glycosylation, has a role in regulation of ITR1 and INO1	dolichol-linked oligosaccharide biosynthetic process|protein N-linked glycosylation	dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity	integral to membrane|endoplasmic reticulum membrane
YDR513W	YDR513W	GRX2	hom	Verified	0.367044078734535	0.356793069512705	no	1720	0.345172783411666	1146	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|RESPONSE TO OXIDATIVE STRESS	MITOCHONDRION		Cytoplasmic glutaredoxin; thioltransferase, glutathione-dependent disulfide oxidoreductase involved in maintaining redox state of target proteins, also exhibits glutathione peroxidase activity, expression induced in response to stress; GRX2 has a paralog, GRX1, that arose from the whole genome duplication	cellular response to oxidative stress	disulfide oxidoreductase activity|glutathione transferase activity|glutathione peroxidase activity	cytosol|mitochondrion
YOR358W	YOR358W	HAP5	hom	Verified	0.366749234473333	0.35690303891588	no	1721	0.351704156213975	1185	NA	FT	TRANSCRIPTION FROM RNA POL II|OXIDATION-REDUCTION PROCESS|RESPONSE TO NUTRIENT LEVELS|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS		Subunit of the heme-activated, glucose-repressed Hap2/3/4/5 CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; required for assembly and DNA binding activity of the complex	carbon catabolite activation of transcription from RNA polymerase II promoter|regulation of cellular respiration	RNA polymerase II core promoter proximal region sequence-specific DNA binding|DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	CCAAT-binding factor complex
YPR083W	YPR083W	MDM36	hom	Verified	0.366321922884623	0.357062436364178	no	1722	0.36661749161565	1198	NA	FT	MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial protein required for normal mitochondrial morphology and inheritance; proposed involvement in the formation of Dnm1p and Num1p-containing cortical anchor complexes that promote mitochondrial fission	mitochondrial fission|mitochondrion organization	molecular_function	mitochondrion|cytoplasm
YDL180W_p	YDL180W	YDL180W	hom	Uncharacterized	0.366059364517741	0.357160389296207	no	1723	0.364954336365654	1229	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole	biological_process	molecular_function	integral to membrane|fungal-type vacuole
YMR173W-A_d	YMR173W-A	YMR173W-A	hom	Dubious	0.365869874972297	0.357231088214151	no	1724	0.370056955865047	1224	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene DDR48/YML173W	Unknown	Unknown	Unknown
YLR428C_d	YLR428C	YLR428C	hom	Dubious	0.365559871596095	0.357346761644759	no	1725	0.366431557840601	1225	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CRN1	Unknown	Unknown	Unknown
YHR108W	YHR108W	GGA2	hom	Verified	0.365226086618082	0.357471323504194	no	1726	0.353624944444442	1226	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEOLYSIS|VACUOLAR TRANSPORT	GOLGI APPARATUS		Protein that interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner to facilitate traffic through the late Golgi; binds phosphatidylinositol 4-phosphate, which plays a role in TGN localization; has homology to gamma-adaptin	protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|Golgi to vacuole transport|Golgi to endosome transport	ubiquitin binding|phosphatidylinositol-4-phosphate binding	trans-Golgi network
YGL160W	YGL160W	AIM14	hom	Verified	0.364914627461021	0.357587567511508	no	1727	0.368017621864443	1237	NA	FT	ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|GEN. OF PRECURSOR METABOLITES AND ENERGY			NADPH oxidase localized to the perinuclear ER; produces superoxide from NADPH; overexpression causes MCA1 dependent apoptosis; likely involved in superoxide-mediated regulation of the actin cytoskeleton; member of a conserved superfamily of NADPH oxidases (NOX enzymes); has similarity to iron/copper reductases (FRE1-8), particularly Fre8p	biological_process	oxidoreductase activity, oxidizing metal ions	integral to membrane|ribosome
YDR505C	YDR505C	PSP1	hom	Verified	0.364771909710407	0.357640837604607	no	1728	0.350664837556199	1167	NA	FT		MITOCHONDRION		Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication	biological_process	molecular_function	mitochondrion|cytoplasm
YLR206W	YLR206W	ENT2	hom	Verified	0.36470069918789	0.357667418314916	no	1729	0.323855157943592	1112	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Epsin-like protein required for endocytosis and actin patch assembly and functionally redundant with Ent1p; contains clathrin-binding motif at C-terminus	actin filament organization|endocytosis|actin cortical patch assembly	clathrin binding	mating projection tip|actin cortical patch
YDR326C	YDR326C	YSP2	hom	Verified	0.364065660806532	0.357904489235998	no	1730	0.362526774339769	1240	NA	FT		MITOCHONDRION		Protein involved in programmed cell death; mutant shows resistance to cell death induced by amiodarone or intracellular acidification; YSP2 has a paralog, YHR080C, that arose from the whole genome duplication	apoptotic process	molecular_function	mitochondrion
YGR168C_p	YGR168C	YGR168C	hom	Uncharacterized	0.363891329605243	0.357969579711889	no	1731	0.383592487464024	1294	NA					Putative protein of unknown function; YGR168C is not an essential gene	biological_process	molecular_function	integral to membrane
YEL050C	YEL050C	RML2	hom	Verified	0.363199496890161	0.358227931713125	no	1732	0.382926094009896	1261	NA	FF|FT	KETONE METABOLISM|LIPID METABOLISM|TRANSLATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L2 ribosomal protein; fat21 mutant allele causes inability to utilize oleate and may interfere with activity of the Adr1p transcription factor	cytoplasmic translation|fatty acid metabolic process	structural constituent of ribosome	mitochondrial large ribosomal subunit
YMR193W	YMR193W	MRPL24	hom	Verified	0.36300013114455	0.358302393181111	no	1733	0.332914823736387	1128	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit; two mitochondrial ribosomal proteins, YmL14 and YmL24, have been assigned to the same gene	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YDR314C	YDR314C	RAD34	hom	Verified	0.362723408677623	0.358405755679501	no	1734	0.374904739803889	1220	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		Protein involved in nucleotide excision repair (NER); homologous to RAD4	nucleotide-excision repair	molecular_function	nucleus
YDL044C	YDL044C	MTF2	hom	Verified	0.361159584855382	0.358990076290626	no	1735	0.372738692208677	1222	NA	FT	RNA PROCESSING|TRANSLATION	MITOCHONDRION		Mitochondrial matrix protein that interacts with an N-terminal region of mitochondrial RNA polymerase (Rpo41p) and couples RNA processing and translation to transcription	cytoplasmic translation|mRNA processing	RNA binding	mitochondrion
YER063W	YER063W	THO1	hom	Verified	0.360627841750541	0.359188836636616	no	1736	0.332635170636392	1114	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA LOCALIZATION	NUCLEUS		Conserved nuclear RNA-binding protein; specifically binds to transcribed chromatin in a THO- and RNA-dependent manner, genetically interacts with shuttling hnRNP NAB2; overproduction suppresses transcriptional defect caused by hpr1 mutation	poly(A)+ mRNA export from nucleus|transcription, DNA-dependent|ribonucleoprotein complex assembly	chromatin binding|double-stranded DNA binding|RNA binding	nucleus
YDR098C	YDR098C	GRX3	hom	Verified	0.359754468191949	0.359515377785667	no	1737	0.353819567058664	1208	NA	FT	ION HOMEOSTASIS|CYTOSKELETON ORGANIZATION|ION HOMEOSTASIS|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx4p and Grx5p; protects cells from oxidative damage; evidence exists indicating that the translation start site is not Met1 as currently annotated, but rather Met36	cellular iron ion homeostasis|cellular response to oxidative stress|actin cytoskeleton organization	disulfide oxidoreductase activity	cytosol|nucleus
YOR041C_d	YOR041C	YOR041C	hom	Dubious	0.359622063371711	0.359564890905984	no	1738	0.335605491314487	1113	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 85% of ORF overlaps the uncharacterized gene CUE5; deletion in cyr1 mutant results in loss of stress resistance	Unknown	Unknown	Unknown
YKL047W_p	YKL047W	ANR2	hom	Uncharacterized	0.359488255529156	0.359614931085337	no	1739	0.358657821437878	1192	NA					Putative protein of unknown function, predicted to be palmitoylated; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	biological_process	molecular_function	cytoplasm
YPL034W_p	YPL034W	YPL034W	hom	Uncharacterized	0.359004130193436	0.359795999759766	no	1740	0.371049245795482	1230	NA					Putative protein of unknown function; YPL034W is not essential gene	biological_process	molecular_function	cellular_component
YLR102C	YLR102C	APC9	hom	Verified	0.35899412279957	0.359799742977083	no	1741	0.350992323523378	1164	NA	FT	CELL CYCLE|CHROMATIN ORGANIZATION|CELL DIVISION	NUCLEUS	UBIQUITIN LIGASE COMPLEX	Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition	chromatin assembly|protein ubiquitination	ubiquitin-protein ligase activity	anaphase-promoting complex
YOL164W-A_p	YOL164W-A	YOL164W-A	hom	Uncharacterized	0.358588671873281	0.359951411242799	no	1742	0.346990994658043	1131	NA					Putative protein of unknown function; identified by fungal homology and RT-PCR	biological_process	molecular_function	cellular_component
YIL023C	YIL023C	YKE4	hom	Verified	0.358251367383376	0.360077604568334	no	1743	0.331550657194051	1095	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Zinc transporter; localizes to the ER; null mutant is sensitive to calcofluor white, leads to zinc accumulation in cytosol; ortholog of the mouse KE4 and member of the ZIP (ZRT, IRT-like Protein) family	zinc ion transport	zinc ion transmembrane transporter activity	integral to membrane|endoplasmic reticulum
YNL281W	YNL281W	HCH1	hom	Verified	0.357862910020956	0.360222954247339	no	1744	0.332245597167233	1096	NA	FT	NUCLEOTIDE METABOLISM	NUCLEUS		Heat shock protein regulator; binds to Hsp90p and may stimulate ATPase activity; originally identified as a high-copy number suppressor of a HSP90 loss-of-function mutation; GFP-fusion protein localizes to the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress	protein folding|response to stress	ATPase activator activity|chaperone binding	nucleus|cytoplasm
YBR206W_d	YBR206W	YBR206W	hom	Dubious	0.357684226676418	0.360289819251053	no	1745	0.362865796035884	1221	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene KTR3	Unknown	Unknown	Unknown
YDR275W	YDR275W	BSC2	hom	Verified	0.356783946560065	0.360626777588954	no	1746	0.369676129365284	1231	NA					Protein of unknown function; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; BSC2 has a paralog, IRC23, that arose from the whole genome duplication	biological_process	molecular_function	lipid particle
YLR407W_p	YLR407W	YLR407W	hom	Uncharacterized	0.356248679779934	0.360827169457578	no	1747	0.364671050638042	1205	NA					Putative protein of unknown function; null mutant displays elongated buds and a large fraction of budded cells have only one nucleus	biological_process	molecular_function	cellular_component
YPL257W_p	YPL257W	YPL257W	hom	Uncharacterized	0.355413534397223	0.361139905454325	no	1748	0.340453323407305	1142	NA	FT	CELL CYCLE			Putative protein of unknown function; homozygous diploid deletion strain exhibits low budding index; physically interacts with Hsp82p; YPL257W is not an essential gene	biological_process	molecular_function	integral to membrane
YLR069C	YLR069C	MEF1	hom	Verified	0.355301130061316	0.361182004478511	no	1749	0.357779406858986	1195	NA	FT	TRANSLATION|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial elongation factor involved in translational elongation	mitochondrial translational elongation|mitochondrial translation	translation elongation factor activity	mitochondrion
YGR045C_d	YGR045C	YGR045C	hom	Dubious	0.355276202297423	0.361191340952341	no	1750	0.351791643478993	1177	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YFL055W	YFL055W	AGP3	hom	Verified	0.355273856468009	0.361192219566289	no	1751	0.361861717304405	1221	NA	FT		PLASMA MEMBRANE		Low-affinity amino acid permease, may act to supply the cell with amino acids as nitrogen source in nitrogen-poor conditions; transcription is induced under conditions of sulfur limitation; plays a role in regulating Ty1 transposition	amino acid transport|transmembrane transport	amino acid transmembrane transporter activity	integral to membrane|plasma membrane
YIL064W	YIL064W	SEE1	hom	Verified	0.355188456399706	0.361224206061206	no	1752	0.360836848802285	1187	NA	FT	VESICLE-MEDIATED TRANSPORT			Probable lysine methyltransferase involved in the dimethylation of eEF1A (Tef1p/Tef2p); sequence similarity to S-adenosylmethionine-dependent methyltransferases of the seven beta-strand family; role in vesicular transport	vesicle-mediated transport|peptidyl-lysine dimethylation	protein-lysine N-methyltransferase activity	cytoplasm
YOR384W	YOR384W	FRE5	hom	Verified	0.353829331785351	0.361733395042439	no	1753	0.374923756468226	1220	NA	FT	ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION|PLASMA MEMBRANE		Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	ferric-chelate reductase activity	mitochondrion|integral to membrane
YOR039W	YOR039W	CKB2	hom	Verified	0.353114778513345	0.362001197003028	no	1754	0.35434165711604	1170	NA	FF|FT	RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION	NUCLEUS		Beta' regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerase	regulation of transcription from RNA polymerase I promoter|protein phosphorylation|regulation of transcription from RNA polymerase III promoter|response to DNA damage stimulus	protein serine/threonine kinase inhibitor activity|protein kinase regulator activity	protein kinase CK2 complex|UTP-C complex|CURI complex
YML028W	YML028W	TSA1	hom	Verified	0.353103166494804	0.362005549541085	no	1755	0.358527675936128	1169	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|TRANSLATION|OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS			Thioredoxin peroxidase; acts as both a ribosome-associated and free cytoplasmic antioxidant; self-associates to form a high-molecular weight chaperone complex under oxidative stress; deletion results in mutator phenotype; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress	protein folding|cellular response to oxidative stress|replicative cell aging|DNA protection|DNA damage checkpoint|cell redox homeostasis|response to hydroperoxide	unfolded protein binding|ribosome binding|peroxiredoxin activity|thioredoxin peroxidase activity	cytosol|polysome|cytoplasm
YJL147C_p	YJL147C	YJL147C	hom	Uncharacterized	0.352960292003695	0.362059104710438	no	1756	0.352645811079322	1201	NA	FT		MITOCHONDRION		Mitochondrial protein of unknown function; homozygous diploid deletion strain has a sporulation defect characterized by elevated dityrosine in the soluble fraction; expression induced by calcium shortage; YJL147W is a non-essential gene	biological_process	molecular_function	mitochondrion
YFL036W	YFL036W	RPO41	hom	Verified	0.352477908225404	0.362239941714277	no	1757	0.367585970903095	1201	NA	FT	MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial RNA polymerase; single subunit enzyme similar to those of T3 and T7 bacteriophages; requires a specificity subunit encoded by MTF1 for promoter recognition; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation	transcription from mitochondrial promoter|mitochondrial genome maintenance	DNA-directed RNA polymerase activity	mitochondrial nucleoid|mitochondrion|mitochondrial DNA-directed RNA polymerase complex|mitochondrial matrix
YBL013W	YBL013W	FMT1	hom	Verified	0.351472694709799	0.362616876946456	no	1758	0.395042145761337	1321	NA	FT	KETONE METABOLISM|RNA PROCESSING|AMINO ACID METABOLISM|TRANSLATION	MITOCHONDRION		Methionyl-tRNA formyltransferase, catalyzes the formylation of initiator Met-tRNA in mitochondria; potential Cdc28p substrate	translational initiation|methionyl-tRNA aminoacylation	methionyl-tRNA formyltransferase activity	mitochondrion
YDR497C	YDR497C	ITR1	hom	Verified	0.350415072677309	0.363013608126347	no	1759	0.353030345371551	1168	NA	FT		PLASMA MEMBRANE		Myo-inositol transporter; has strong similarity to the minor myo-inositol transporter Itr2p, member of the sugar transporter superfamily; expression is repressed by inositol and choline via Opi1p and derepressed via Ino2p and Ino4p; relative distribution to the vacuole increases upon DNA replication stress	myo-inositol transport|transmembrane transport	myo-inositol transmembrane transporter activity	integral to membrane|plasma membrane|membrane
YMR086C-A_d	YMR086C-A	YMR086C-A	hom	Dubious	0.3502572731782	0.363072813895144	no	1760	0.363038050034498	1229	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YNR071C_p	YNR071C	YNR071C	hom	Uncharacterized	0.349678362575116	0.363290046954749	no	1761	0.362216591327892	1197	NA	FT	CARBOHYDRATE METABOLISM			Putative aldose 1-epimerase	biological_process	molecular_function	cellular_component
YKL174C	YKL174C	TPO5	hom	Verified	0.349539970600693	0.363341984307352	no	1762	0.351320819898701	1143	NA	FT		ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Protein involved in excretion of putrescine and spermidine; putative polyamine transporter in the Golgi or post-Golgi vesicles	polyamine transport	polyamine transmembrane transporter activity	integral to membrane|Golgi apparatus
YPL159C	YPL159C	PET20	hom	Verified	0.34937804942436	0.363402755162442	no	1763	0.368708234974399	1205	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Mitochondrial protein, required for respiratory growth under some conditions and for stability of the mitochondrial genome	aerobic respiration	molecular_function	mitochondrion
YDL052C	YDL052C	SLC1	hom	Verified	0.349078438049358	0.363515211776969	no	1764	0.386041878539879	1280	NA	FT	LIPID METABOLISM			1-acyl-sn-glycerol-3-phosphate acyltransferase, catalyzes the acylation of lysophosphatidic acid to form phosphatidic acid, a key intermediate in lipid metabolism; enzymatic activity detected in lipid particles and microsomes	glycerophospholipid biosynthetic process	1-acylglycerol-3-phosphate O-acyltransferase activity	lipid particle
YDR077W	YDR077W	SED1	hom	Verified	0.347863626020132	0.363971301712924	no	1765	0.360774905722084	1192	NA	FT	CELL WALL ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Major stress-induced structural GPI-cell wall glycoprotein in stationary-phase cells, associates with translating ribosomes, possible role in mitochondrial genome maintenance; ORF contains two distinct variable minisatellites	fungal-type cell wall organization|mitochondrial genome maintenance	structural constituent of cell wall	mitochondrion|ribosome|fungal-type cell wall
YDR338C_p	YDR338C	YDR338C	hom	Uncharacterized	0.347605034449336	0.364068412431133	no	1766	0.385181953203467	1294	NA					Putative protein of unknown function, member of the multi-drug and toxin extrusion (MATE) family of the multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter superfamily	transmembrane transport	antiporter activity	integral to membrane
YDR119W_p	YDR119W	VBA4	hom	Uncharacterized	0.34706541906895	0.364271086112253	no	1767	0.339940762330711	1140	NA					Protein of unknown function with proposed role as a basic amino acid permease based on phylogeny; GFP-fusion protein localizes to vacuolar membrane; physical interaction with Atg27p suggests a possible role in autophagy; non-essential gene	biological_process	molecular_function	fungal-type vacuole membrane|integral to membrane
YNL264C	YNL264C	PDR17	hom	Verified	0.345674405141341	0.364793710773956	no	1768	0.368075705864742	1230	NA	FT	LIPID METABOLISM			Phosphatidylinositol transfer protein (PITP), downregulates Plb1p-mediated turnover of phosphatidylcholine, found in the cytosol and microsomes, homologous to Pdr16p, deletion affects phospholipid composition	Golgi to plasma membrane protein transport|phosphatidylserine metabolic process|response to drug|sterol biosynthetic process|Unknown|phospholipid transport|phospholipid biosynthetic process	phosphatidylinositol transporter activity|phosphatidylcholine transporter activity	endosome|cell periphery|cytosol|cytoplasm
YIL087C	YIL087C	AIM19	hom	Verified	0.345616861167069	0.364815336322967	no	1769	0.356939272437235	1231	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays reduced respiratory growth	biological_process	molecular_function	mitochondrion
YLR019W	YLR019W	PSR2	hom	Verified	0.345604739414311	0.364819891842771	no	1770	0.36657808964978	1220	NA	FT		PLASMA MEMBRANE		Functionally redundant Psr1p homolog, a plasma membrane phosphatase involved in the general stress response; required with Psr1p and Whi2p for full activation of STRE-mediated gene expression, possibly through dephosphorylation of Msn2p	response to stress	phosphoprotein phosphatase activity	plasma membrane
YFL010W-A	YFL010W-A	AUA1	hom	Verified	0.345346646180013	0.364916891323975	no	1771	0.375871943191911	1233	NA					Protein required for the negative regulation by ammonia of Gap1p, which is a general amino acid permease	amino acid transport	molecular_function	cellular_component
YDR179W-A_p	YDR179W-A	YDR179W-A	hom	Uncharacterized	0.345243249268074	0.364955753532002	no	1772	0.369909504213338	1198	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YER092W	YER092W	IES5	hom	Verified	0.34512136041737	0.365001567802436	no	1773	0.363087897176756	1191	NA	FT		NUCLEUS		Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions	biological_process	molecular_function	nucleus
YOR127W	YOR127W	RGA1	hom	Verified	0.344838777345629	0.36510778950107	no	1774	0.376931980710348	1270	NA	FT	SIGNALING|CELL DIVISION|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		GTPase-activating protein for polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth; relocalizes from bud neck to cytoplasm upon DNA replication stress	budding cell isotropic bud growth|pheromone-dependent signal transduction involved in conjugation with cellular fusion|pseudohyphal growth|actin filament organization|establishment of cell polarity|small GTPase mediated signal transduction|invasive growth in response to glucose limitation|budding cell apical bud growth	Rho GTPase activator activity	cellular bud neck split septin rings
YLR286C	YLR286C	CTS1	hom	Verified	0.344581299511504	0.365204583267362	no	1775	0.343302076796541	1180	NA	FT	CELL WALL ORG/BIOGENESIS|CELL DIVISION|CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|SITE OF POLARIZED GROWTH		Endochitinase, required for cell separation after mitosis; transcriptional activation during the G1 phase of the cell cycle is mediated by transcription factor Ace2p	cytokinesis, completion of separation|chitin catabolic process	endochitinase activity	nuclear envelope|extracellular region|fungal-type cell wall|endoplasmic reticulum|cellular bud neck
YGL079W_p	YGL079W	KXD1	hom	Uncharacterized	0.344344032195502	0.365293786887367	no	1776	0.358364824206215	1178	NA					Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; null mutant is sensitive to drug inducing secretion of vacuolar cargo; GFP-fusion protein localizes to the endosome	biological_process	molecular_function	endosome
YIR002C	YIR002C	MPH1	hom	Verified	0.343462437369077	0.365625297323535	no	1777	0.358228705919946	1207	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		3'-5' DNA helicase involved in error-free bypass of DNA lesions; binds to flap DNA in an error-free bypass pathway and stimulates the activity of Rad27p and Dna2p; also involved in interstrand cross-link repair mutations confer a mutator phenotype; similarity to FANCM, a human Fanconi anemia complementation group protein that along with the MHF complex is involved in stabilizing and remodeling blocked replication forks; member of the SF2 DExD/H superfamily of helicases	negative regulation of strand invasion|recombinational repair|DNA replication, Okazaki fragment processing	flap-structured DNA binding|3'-5' DNA helicase activity	nucleus
YMR057C_d	YMR057C	YMR057C	hom	Dubious	0.342658621641012	0.365927647608298	no	1778	0.364291965227821	1185	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF AAC1	Unknown	Unknown	Unknown
YOL056W	YOL056W	GPM3	hom	Verified	0.342639955173667	0.365934669874055	no	1779	0.369042062445818	1239	NA	FT	CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY			Homolog of Gpm1p phosphoglycerate mutase, which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event	biological_process	phosphoglycerate mutase activity|molecular_function	cytosol
YOR138C	YOR138C	RUP1	hom	Verified	0.342573136128066	0.365959807355018	no	1780	0.378050118025511	1246	NA	FT		NUCLEUS		Protein that regulates Rsp5p, which is a HECT ubiquitin ligase; has a WW domain consensus motif of PPPSY (residues 131-135) that mediates binding of Rsp5p to Ubp2p; contains an UBA domain; relative distribution to the nucleus increases upon DNA replication stress	protein deubiquitination	protein binding	nucleus|cytoplasm
YLR017W	YLR017W	MEU1	hom	Verified	0.342062263090832	0.366152017994896	no	1781	0.347673400105335	1154	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Methylthioadenosine phosphorylase (MTAP), catalyzes the initial step in the methionine salvage pathway; affects polyamine biosynthesis through regulation of ornithine decarboxylase (Spe1p) activity; regulates ADH2 gene expression	L-methionine salvage from methylthioadenosine|glutamate biosynthetic process	S-methyl-5-thioadenosine phosphorylase activity|mRNA binding	cytoplasm
YGR169C-A_p	YGR169C-A	YGR169C-A	hom	Uncharacterized	0.341985483052858	0.36618090858632	no	1782	0.367582788717768	1226	NA					Putative protein of unknown function; YGR169C-A has a paralog, YJR005C-A, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YIL027C	YIL027C	EMC5	hom	Verified	0.341894443823599	0.36621516557187	no	1783	0.390578381415887	1313	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response, and also shows K1 killer toxin resistance; homologous to worm B0334.15/EMC-5, fly CG15168, human MMGT	protein folding in endoplasmic reticulum	molecular_function	ER membrane protein complex|endoplasmic reticulum
YNL090W	YNL090W	RHO2	hom	Verified	0.341340494703945	0.366423633049941	no	1784	0.372872254964704	1238	NA	FT	SIGNALING|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION	PLASMA MEMBRANE		Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, involved in the establishment of cell polarity and in microtubule assembly	microtubule-based process|fungal-type cell wall organization|actin filament organization|establishment of cell polarity|small GTPase mediated signal transduction	GTPase activity	membrane
YDR093W	YDR093W	DNF2	hom	Verified	0.34106424902229	0.366527607225398	no	1785	0.362200681212667	1212	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase	intracellular protein transport|phospholipid translocation|endocytosis|establishment or maintenance of cell polarity	phospholipid-translocating ATPase activity	integral to membrane|plasma membrane
YGL214W_d	YGL214W	YGL214W	hom	Dubious	0.340876513103751	0.366598273423251	no	1786	0.35487874770836	1192	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; deletion mutation phenotype is likely due to the overlapping verified ORF SKI8/YGL213C	Unknown	Unknown	Unknown
YMR107W	YMR107W	SPG4	hom	Verified	0.340348301863948	0.366797123136486	no	1787	0.354114233731193	1219	NA					Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources	biological_process	molecular_function	cellular_component
YGR174C	YGR174C	CBP4	hom	Verified	0.340062038774809	0.366904904306163	no	1788	0.364500162479397	1211	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial protein required for assembly of cytochrome bc1 complex; interacts with the Cbp3p-Cbp6p complex and newly synthesized cytochrome b (Cobp) to promote assembly of Cobp into the cytochrome bc1 complex	mitochondrial respiratory chain complex III assembly	molecular_function	mitochondrion|integral to mitochondrial membrane
YOL036W_p	YOL036W	YOL036W	hom	Uncharacterized	0.339209648479214	0.367225900640076	no	1789	0.370033854482091	1222	NA					Protein of unknown function; potential Cdc28p substrate; YOL036W has a paralog, YIR016W, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YJL150W_d	YJL150W	YJL150W	hom	Dubious	0.339074065006935	0.367276967734693	no	1790	0.343123574596369	1150	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YCR053W	YCR053W	THR4	hom	Verified	0.33896795605599	0.367316934979905	no	1791	0.351111188414589	1165	NA	FT	VESICLE-MEDIATED TRANSPORT|KETONE METABOLISM|MEMBRANE ORGANIZATION|AMINO ACID METABOLISM	NUCLEUS		Threonine synthase, conserved protein that catalyzes formation of threonine from O-phosphohomoserine; expression is regulated by the GCN4-mediated general amino acid control pathway	endocytosis|threonine metabolic process	threonine synthase activity	nucleus|cytoplasm
YOR216C	YOR216C	RUD3	hom	Verified	0.338452027958128	0.367511286142292	no	1792	0.368766809017098	1230	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	GOLGI APPARATUS		Golgi matrix protein involved in the structural organization of the cis-Golgi; interacts genetically with COG3 and USO1	ER to Golgi vesicle-mediated transport	molecular_function	Golgi apparatus
YIR029W	YIR029W	DAL2	hom	Verified	0.338359485346378	0.367546150723348	no	1793	0.356770861762189	1172	NA					Allantoicase, converts allantoate to urea and ureidoglycolate in the second step of allantoin degradation; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation	allantoin catabolic process	allantoicase activity	cellular_component
YCR089W	YCR089W	FIG2	hom	Verified	0.338115527389667	0.367638064879958	no	1794	0.357728163560602	1171	NA	FT	CELL WALL ORG/BIOGENESIS			Cell wall adhesin, expressed specifically during mating; may be involved in maintenance of cell wall integrity during mating	filamentous growth of a population of unicellular organisms|cell morphogenesis involved in conjugation with cellular fusion|invasive growth in response to glucose limitation|cytogamy	molecular_function	fungal-type cell wall|mating projection
YMR278W	YMR278W	PGM3	hom	Verified	0.33807713004039	0.367652532243623	no	1795	0.348863463877372	1174	NA	FT	CARBOHYDRATE METABOLISM	NUCLEUS		Phosphoglucomutase, catalyzes interconversion of glucose-1-phosphate and glucose-6-phospate; transcription induced in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; non-essential	biological_process	phosphoglucomutase activity	nucleus|cytoplasm
YIL101C	YIL101C	XBP1	hom	Verified	0.337739124037782	0.367779894337929	no	1796	0.365009093471499	1204	NA	FT		NUCLEUS		Transcriptional repressor; binds to promoter sequences of the cyclin genes, CYS3, and SMF2; expression is induced by stress or starvation during mitosis, and late in meiosis; member of the Swi4p/Mbp1p family; potential Cdc28p substrate; relative distribution to the nucleus increases upon DNA replication stress	response to stress	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	nucleus
YNL082W	YNL082W	PMS1	hom	Verified	0.337591448328547	0.367835543735876	no	1797	0.369087806928392	1227	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS		ATP-binding protein required for mismatch repair in mitosis and meiosis; functions as a heterodimer with Mlh1p, binds double- and single-stranded DNA via its N-terminal domain, similar to E. coli MutL	mismatch repair|meiotic mismatch repair	double-stranded DNA binding|DNA insertion or deletion binding|loop DNA binding|single-stranded DNA binding|dinucleotide insertion or deletion binding|ATPase activity|ATP binding	nucleus|MutLalpha complex|cytoplasm
YBR010W	YBR010W	HHT1	hom	Verified	0.337184535141739	0.367988897278931	no	1798	0.379652554830574	1278	NA	FT	CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Histone H3, core histone protein required for chromatin assembly, part of heterochromatin-mediated telomeric and HM silencing; one of two identical histone H3 proteins (see HHT2); regulated by acetylation, methylation, and phosphorylation	chromatin assembly or disassembly|global genome nucleotide-excision repair|rRNA transcription|sexual sporulation resulting in formation of a cellular spore|mitotic cell cycle spindle assembly checkpoint	DNA binding	replication fork protection complex|nucleus|nuclear nucleosome
YFR032C-A	YFR032C-A	RPL29	hom	Verified	0.336906635274523	0.368093641612195	no	1799	0.36938473305785	1233	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L29; not essential for translation, but required for proper joining of large and small ribosomal subunits and for normal translation rate; homologous to mammalian ribosomal protein L29, no bacterial homolog	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit|cytoplasm
YJR051W	YJR051W	OSM1	hom	Verified	0.336111380663498	0.368393438323515	no	1800	0.362866727123943	1208	NA	FT	OXIDATION-REDUCTION PROCESS	MITOCHONDRION		Fumarate reductase, catalyzes the reduction of fumarate to succinate; required for the reoxidation of intracellular NADH under anaerobic conditions; mutations cause osmotic sensitivity; OSM1 has a paralog, FRD1, that arose from the whole genome duplication	cellular response to anoxia	fumarate reductase (NADH) activity	mitochondrion
YEL053C	YEL053C	MAK10	hom	Verified	0.336046553134105	0.368417880673431	no	1801	0.367359902929743	1226	NA					Non-catalytic subunit of N-terminal acetyltransferase of the NatC type, required for replication of dsRNA virus; expression is glucose-repressible	N-terminal protein amino acid acetylation	peptide alpha-N-acetyltransferase activity	NatC complex|cytoplasm
YEL020C_p	YEL020C	YEL020C	hom	Uncharacterized	0.335841796979317	0.368495084730099	no	1802	0.372841700892761	1225	NA					Protein of unknown function with low sequence identity to Pdc1p; mRNA identified as translated by ribosome profiling data	biological_process	molecular_function	cytoplasm
YJR146W_p	YJR146W	YJR146W	hom	Uncharacterized	0.335840138025326	0.368495710266452	no	1803	0.36400968001119	1220	NA					Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps HMS2	biological_process	molecular_function	cellular_component
YNR048W	YNR048W	YNR048W	hom	Verified	0.335650860964843	0.368567082636146	no	1804	0.369181808118762	1237	NA					Protein that interacts with phospholipid translocase (flippase) Dnf3p; YNR048W has a paralog, CDC50, that arose from the whole genome duplication	response to drug	phospholipid-translocating ATPase activity	integral to membrane
YPL098C	YPL098C	MGR2	hom	Verified	0.334795680404864	0.368889609601759	no	1805	0.397004926612115	1321	NA	FT		MITOCHONDRION		Subunit of the TIM23 translocase complex; acts to couple Tim21p with the core Tim23 translocase; absolutely required for mitochondrial import of presequence-containing proteins at elevated temperature; required for viability of cells lacking the mitochondrial genome (petite-negative phenotype)	protein import into mitochondrial matrix	molecular_function	mitochondrial inner membrane presequence translocase complex
YJL062W	YJL062W	LAS21	hom	Verified	0.33380348985702	0.369263924904392	no	1806	0.373937322378204	1245	NA	FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|PLASMA MEMBRANE		Integral plasma membrane protein involved in the synthesis of the glycosylphosphatidylinositol (GPI) core structure; mutations affect cell wall integrity	GPI anchor biosynthetic process	mannose-ethanolamine phosphotransferase activity|transferase activity	integral to endoplasmic reticulum membrane|integral to membrane|integral to plasma membrane
YKR006C	YKR006C	MRPL13	hom	Verified	0.333730004864466	0.369291652899269	no	1807	0.361113578775443	1209	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit, not essential for mitochondrial translation	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YGR249W	YGR249W	MGA1	hom	Verified	0.332776758712145	0.36965140158312	no	1808	0.370298602972799	1256	NA	FT		NUCLEUS		Protein similar to heat shock transcription factor; multicopy suppressor of pseudohyphal growth defects of ammonium permease mutants	filamentous growth	sequence-specific DNA binding|DNA binding|sequence-specific DNA binding transcription factor activity	nucleus
YJR100C	YJR100C	AIM25	hom	Verified	0.332238857656695	0.36985445221504	no	1809	0.355466941738005	1197	NA	FT		MITOCHONDRION		Putative protein of unknown function; non-tagged protein is detected in purified mitochondria in high-throughput studies; similar to murine NOR1; null mutant is viable and displays elevated frequency of mitochondrial genome loss	biological_process	molecular_function	mitochondrion
YPR096C	YPR096C	YPR096C	hom	Verified	0.332224227140209	0.369859975551371	no	1810	0.357760256620508	1186	NA					Protein of unknown function that may interact with ribosomes, based on co-purification experiments	biological_process	molecular_function	ribosome
YCL025C	YCL025C	AGP1	hom	Verified	0.331360821453273	0.370185977373055	no	1811	0.332037503862984	1104	NA	FT		PLASMA MEMBRANE		Low-affinity amino acid permease with broad substrate range; involved in uptake of asparagine, glutamine, and other amino acids; expression regulated by SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p); AGP1 has a paralog, GNP1, that arose from the whole genome duplication	amino acid transport|transmembrane transport	amino acid transmembrane transporter activity|L-proline transmembrane transporter activity	integral to membrane|plasma membrane
YDR183W	YDR183W	PLP1	hom	Verified	0.330848360443546	0.370379514809066	no	1812	0.352626825869663	1155	NA	FT	TRANSCRIPTION FROM RNA POL II|SIGNALING			Protein that interacts with CCT (chaperonin containing TCP-1) complex and has a role in actin and tubulin folding; has weak similarity to phosducins, which are G-protein regulators	protein folding|positive regulation of transcription from RNA polymerase II promoter by pheromones	G-protein beta/gamma-subunit complex binding	cellular_component
YKL055C	YKL055C	OAR1	hom	Verified	0.330814568169781	0.370392278046044	no	1813	0.384393548310035	1279	NA	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Mitochondrial 3-oxoacyl-[acyl-carrier-protein] reductase, may comprise a type II mitochondrial fatty acid synthase along with Mct1p	fatty acid metabolic process|aerobic respiration	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity	mitochondrion
YJL047C	YJL047C	RTT101	hom	Verified	0.330211790058951	0.370619969428458	no	1814	0.386475800916263	1281	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|PROTEOLYSIS	NUCLEUS	UBIQUITIN LIGASE COMPLEX	Cullin subunit of a Roc1p-dependent E3 ubiquitin ligase complex with a role in anaphase progression; implicated in Mms22-dependent DNA repair; involved with Mms1p in nonfunctional rRNA decay; modified by the ubiquitin-like protein, Rub1p	replication fork processing|negative regulation of transposition, RNA-mediated|regulation of mitosis|nonfunctional rRNA decay|ubiquitin-dependent protein catabolic process	ubiquitin-protein ligase activity	Cul8-RING ubiquitin ligase complex|nucleus|cytoplasm
YDR319C_p	YDR319C	YFT2	hom	Uncharacterized	0.32953361165565	0.370876196445124	no	1815	0.365587497520051	1232	NA					Protein required for normal ER membrane biosynthesis; member of the highly conserved FIT family of proteins involved in triglyceride droplet biosynthesis and homologous to human FIT2; interacts with Sst2p and Hsp82p in high-throughput two-hybrid screens	biological_process	molecular_function	integral to membrane
YGR035W-A_p	YGR035W-A	YGR035W-A	hom	Uncharacterized	0.329402893101585	0.370925590663046	no	1816	0.356517883987776	1195	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YPL033C	YPL033C	SRL4	hom	Verified	0.329260900215426	0.370979247488124	no	1817	0.377113438780834	1243	NA	FT	NUCLEOTIDE METABOLISM			Protein of unknown function; involved in regulation of dNTP production; null mutant suppresses the lethality of lcd1 and rad53 mutations; expression is induced by Kar4p	deoxyribonucleoside triphosphate metabolic process	molecular_function	cellular_component
YJR011C_p	YJR011C	YJR011C	hom	Uncharacterized	0.329025131594159	0.371068346193825	no	1818	0.365109553312456	1198	NA					Putative protein of unknown function; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS	biological_process	molecular_function	cellular_component
YKR053C	YKR053C	YSR3	hom	Verified	0.328795879165457	0.371154989010284	no	1819	0.376930528547849	1277	NA	FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Dihydrosphingosine 1-phosphate phosphatase; membrane protein involved in sphingolipid metabolism; YSR3 has a paralog, LCB3, that arose from the whole genome duplication	phospholipid dephosphorylation|sphingolipid biosynthetic process	sphingosine-1-phosphate phosphatase activity	integral to membrane|endoplasmic reticulum
YIL005W	YIL005W	EPS1	hom	Verified	0.328736508954841	0.371177428233349	no	1820	0.362061090815372	1224	NA	FT	PROTEIN LOCALIZATION|PROTEOLYSIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		ER protein with chaperone and co-chaperone activity, involved in retention of resident ER proteins; has a role in recognizing proteins targeted for ER-associated degradation (ERAD), member of the protein disulfide isomerase family	protein retention in ER lumen|ER-associated protein catabolic process	unfolded protein binding|protein disulfide isomerase activity|chaperone binding	endoplasmic reticulum membrane
YGL243W	YGL243W	TAD1	hom	Verified	0.32870361596066	0.371189860468635	no	1821	0.361704237988643	1201	NA	FT	RNA PROCESSING	NUCLEUS		tRNA-specific adenosine deaminase, deaminates adenosine-37 to inosine in tRNA-Ala	tRNA modification	tRNA-specific adenosine-37 deaminase activity	nucleus
YDL121C_p	YDL121C	YDL121C	hom	Uncharacterized	0.328657843503231	0.371207160849208	no	1822	0.365723687954171	1206	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDL121C is not an essential protein	biological_process	molecular_function	endoplasmic reticulum
YNL065W	YNL065W	AQR1	hom	Verified	0.328547158908845	0.371248996812231	no	1823	0.363380981271393	1218	NA	FT		PLASMA MEMBRANE		Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; confers resistance to short-chain monocarboxylic acids and quinidine; involved in the excretion of excess amino acids; AQR1 has a paralog, QDR1, that arose from the whole genome duplication; relocalizes from plasma membrane to cytoplasm upon DNA replication stress	monocarboxylic acid transport|drug transmembrane transport|amino acid export	monocarboxylic acid transmembrane transporter activity|drug transmembrane transporter activity	integral to membrane|plasma membrane
YBR147W	YBR147W	RTC2	hom	Verified	0.328103409373704	0.371416738128162	no	1824	0.360188650594714	1203	NA	FT		MITOCHONDRION		Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; positive regulation by Lys14p suggests that lysine may be the primary substrate; member of the PQ-loop family, with seven transmembrane domains; similar to mammalian PQLC2 vacuolar transporter	biological_process	molecular_function	mitochondrion|integral to membrane
YPR059C_d	YPR059C	YPR059C	hom	Dubious	0.328015415322202	0.371450003573914	no	1825	0.390880733126699	1296	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YMC1/YPR058W	Unknown	Unknown	Unknown
YPL156C	YPL156C	PRM4	hom	Verified	0.32799965623216	0.371455961272953	no	1826	0.357599811924267	1210	NA					Pheromone-regulated protein proposed to be involved in mating; predicted to have 1 transmembrane segment; transcriptionally regulated by Ste12p during mating and by Cat8p during the diauxic shift	biological_process	molecular_function	integral to membrane
YAL053W	YAL053W	FLC2	hom	Verified	0.327650971896644	0.371587788710254	no	1827	0.38561044042755	1311	NA	FT	CELL WALL ORG/BIOGENESIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance; FLC2 has a paralog, YOR365C, that arose from the whole genome duplication	protein folding|fungal-type cell wall biogenesis|FAD transport|transmembrane transport	FAD transmembrane transporter activity	integral to membrane|endoplasmic reticulum|cytoplasm
YKL061W_p	YKL061W	BLI1	hom	Uncharacterized	0.327244459369047	0.371741498325039	no	1828	0.367772866029432	1211	NA					Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to the endosome	biological_process	molecular_function	endosome
YMR243C	YMR243C	ZRC1	hom	Verified	0.327074087380474	0.371805925085713	no	1829	0.37633277700002	1236	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Vacuolar membrane zinc transporter; transports zinc from cytosol to vacuole for storage; also has role in resistance to zinc shock resulting from sudden influx of zinc into cytoplasm; human ortholog SLC30A10 functions as a Mn transporter and mutations in SLC30A10 cause neurotoxic accumulation of Mn in liver and brain; ZRC1 has a paralog, COT1, that arose from the whole genome duplication	cobalt ion transport|cellular zinc ion homeostasis|zinc ion transport|glutathione metabolic process	zinc ion transmembrane transporter activity|inorganic cation transmembrane transporter activity	integral to membrane|fungal-type vacuole
YPL249C	YPL249C	GYP5	hom	Verified	0.326817860135497	0.371902825069918	no	1830	0.361105645583746	1185	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING|NUCLEOTIDE METABOLISM	GOLGI APPARATUS|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		GTPase-activating protein (GAP) for yeast Rab family members; involved in ER to Golgi trafficking; exhibits GAP activity toward Ypt1p that is stimulated by Gyl1p, also acts on Sec4p; interacts with Gyl1p, Rvs161p and Rvs167p; involved in recruiting Rvs167p to the bud tip during polarized growth; relocalizes from bud neck to cytoplasm upon DNA replication stress	vesicle-mediated transport|ER to Golgi vesicle-mediated transport	Rab GTPase activator activity	cytosol|incipient cellular bud site|plasma membrane|cellular bud neck|Golgi-associated vesicle|cellular bud tip
YOL163W_p	YOL163W	YOL163W	hom	Uncharacterized	0.32673699487081	0.371933408369471	no	1831	0.359888961747272	1191	NA					Putative protein of unknown function; member of the Dal5p subfamily of the major facilitator family	transmembrane transport	transmembrane transporter activity	integral to membrane|membrane
YJR108W	YJR108W	ABM1	hom	Verified	0.326730684756469	0.37193579489311	no	1832	0.359951423433819	1204	NA	FT	CYTOSKELETON ORGANIZATION			Protein of unknown function, required for normal microtubule organization	microtubule cytoskeleton organization	molecular_function	cellular_component
YJL178C	YJL178C	ATG27	hom	Verified	0.326523984280237	0.372013972990832	no	1833	0.359076955653172	1213	NA	FT	PROTEIN LOCALIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS|PEROXISOME ORGANIZATION	ENDOMEMBRANE SYSTEM|MITOCHONDRION|GOLGI APPARATUS		Type I membrane protein involved in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; may be involved in membrane delivery to the phagophore assembly site	vesicle organization|peroxisome degradation|protein localization to pre-autophagosomal structure|CVT pathway|autophagic vacuole assembly	phosphatidylinositol-3-phosphate binding	trans-Golgi network|mitochondrion|pre-autophagosomal structure|membrane
YLL006W	YLL006W	MMM1	hom	Verified	0.326047345168019	0.372194267182923	no	1834	0.397443748633487	1304	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION		ER integral membrane protein, component of the ERMES complex that links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth	mitochondrion organization|mitochondrial genome maintenance|protein import into mitochondrial outer membrane|phospholipid transport	molecular_function	mitochondrial outer membrane|mitochondrion|integral to endoplasmic reticulum membrane|ERMES complex
YHL003C	YHL003C	LAG1	hom	Verified	0.325460873142586	0.372416145376487	no	1835	0.355131689584213	1173	NA	FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Ceramide synthase component; involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p; forms ER foci upon DNA replication stress	replicative cell aging|ceramide biosynthetic process	sphingosine N-acyltransferase activity	integral to membrane|endoplasmic reticulum
YOR161C	YOR161C	PNS1	hom	Verified	0.325393735824205	0.372441547938902	no	1836	0.374053935189924	1261	NA	FT		PLASMA MEMBRANE		Protein of unknown function; has similarity to Torpedo californica tCTL1p, which is postulated to be a choline transporter, neither null mutation nor overexpression affects choline transport	biological_process	choline transmembrane transporter activity|molecular_function	integral to membrane|plasma membrane|integral to plasma membrane
YGR210C_p	YGR210C	YGR210C	hom	Uncharacterized	0.325350351772713	0.372457963338263	no	1837	0.361252618926337	1163	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	biological_process	molecular_function	cytoplasm
YBR031W	YBR031W	RPL4A	hom	Verified	0.324970297108495	0.372601776064179	no	1838	0.367306792874534	1245	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L4A; N-terminally acetylated; homologous to mammalian ribosomal protein L4 and bacterial L4; RPL4A has a paralog, RPL4B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YCR023C	YCR023C	YCR023C	hom	Verified	0.324908217643716	0.372625268628531	no	1839	0.368244900395054	1219	NA					Vacuolar membrane protein of unknown function; member of the multidrug resistance family; YCR023C is not an essential gene	biological_process	molecular_function	fungal-type vacuole membrane|integral to membrane
YKR092C	YKR092C	SRP40	hom	Verified	0.324527518908352	0.372769345783707	no	1840	0.373409403065951	1223	NA	FT		NUCLEUS		Nucleolar, serine-rich protein with a role in preribosome assembly or transport; may function as a chaperone of small nucleolar ribonucleoprotein particles (snoRNPs); immunologically and structurally to rat Nopp140	nucleocytoplasmic transport	molecular_function	nucleolus
YNL213C	YNL213C	RRG9	hom	Verified	0.324503616599784	0.372778392314414	no	1841	0.37719878518118	1261	NA	FT	MITOCHONDRION ORGANIZATION	MITOCHONDRION		Protein of unknown function; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	mitochondrion organization|mitochondrial genome maintenance	molecular_function	mitochondrion
YIL153W	YIL153W	RRD1	hom	Verified	0.3242087022374	0.372890017089208	no	1842	0.383166162142831	1272	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|RESPONSE TO DNA DAMAGE|CYTOSKELETON ORGANIZATION	NUCLEUS|CHROMOSOME		Peptidyl-prolyl cis/trans-isomerase; activator of the phosphotyrosyl phosphatase activity of PP2A; involved in G1 phase progression, microtubule dynamics, bud morphogenesis and DNA repair; required for rapid reduction of Sgs1p levels in response to rapamycin; subunit of the Tap42p-Sit4p-Rrd1p complex; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress	DNA repair|mitotic spindle organization in nucleus|G1/S transition of mitotic cell cycle|response to osmotic stress|regulation of transcription from RNA polymerase II promoter in response to stress	peptidyl-prolyl cis-trans isomerase activity|protein phosphatase type 2A regulator activity	nuclear chromatin|nucleus|cytoplasm
YDL034W_d	YDL034W	YDL034W	hom	Dubious	0.324103955424999	0.372929666216257	no	1843	0.368325346136428	1223	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps with verified gene GPR1/YDL035C; YDL034W is not an essential gene	Unknown	Unknown	Unknown
YML074C	YML074C	FPR3	hom	Verified	0.323777520124963	0.373053238271462	no	1844	0.353141739456617	1177	NA	FT	CELL CYCLE|CHROMATIN ORGANIZATION	NUCLEUS		Nucleolar peptidyl-prolyl cis-trans isomerase (PPIase); FK506 binding protein; phosphorylated by casein kinase II (Cka1p-Cka2p-Ckb1p-Ckb2p) and dephosphorylated by Ptp1p	meiotic recombination checkpoint	peptidyl-prolyl cis-trans isomerase activity|macrolide binding	nucleolus
YNR042W_d	YNR042W	YNR042W	hom	Dubious	0.323732937363088	0.373070116086197	no	1845	0.369765725416554	1217	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2	Unknown	Unknown	Unknown
YAL019W	YAL019W	FUN30	hom	Verified	0.323710761970753	0.373078511174168	no	1846	0.370616238632784	1212	NA	FT	CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS|MITOCHONDRION|CHROMOSOME		Snf2p family member with ATP-dependent chromatin remodeling activity; has a role in silencing at the mating type locus, telomeres and centromeres; enriched at centromeres and is required for correct chromatin structure around centromeres, as well as at the boundary element of the silent HMR; recruited to DNA double-strand breaks (DSBs) where it promotes 5' strand resection of DSBs; potential Cdc28p substrate	chromosome organization|chromatin silencing at rDNA|heterochromatin maintenance involved in chromatin silencing|chromatin silencing at telomere|chromatin silencing at silent mating-type cassette|heterochromatin assembly involved in chromatin silencing	chromatin binding|DNA-dependent ATPase activity|DNA binding|protein homodimerization activity	mitochondrion|mating-type region heterochromatin|nucleus
YKL096W	YKL096W	CWP1	hom	Verified	0.323014521160251	0.37334212238787	no	1847	0.363743043995903	1217	NA	FT	MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS			Cell wall mannoprotein that localizes specifically to birth scars of daughter cells, linked to a beta-1,3- and beta-1,6-glucan heteropolymer through a phosphodiester bond; required for propionic acid resistance	fungal-type cell wall organization|ascospore-type prospore membrane assembly	structural constituent of cell wall	fungal-type cell wall|cellular birth scar|prospore membrane
YDR063W	YDR063W	AIM7	hom	Verified	0.322809401803381	0.373419796143593	no	1848	0.367739921970094	1229	NA	FT	CYTOSKELETON ORGANIZATION	NUCLEUS|CYTOSKELETON		Protein that interacts with Arp2/3 complex to stimulate actin filament debranching and inhibit actin nucleation; has similarity to Cof1p and also to human glia maturation factor (GMF); null mutant displays elevated mitochondrial genome loss	actin filament debranching|negative regulation of Arp2/3 complex-mediated actin nucleation	molecular_function	nucleus|actin cortical patch|cytoplasm
YLR446W_p	YLR446W	YLR446W	hom	Uncharacterized	0.322803351771289	0.373422087223004	no	1849	0.369866509924344	1209	NA	FT	CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY			Putative hexokinase; transcript is upregulated during sporulation and the unfolded protein response; YLR446W is not an essential gene	biological_process	molecular_function	cellular_component
YML007C-A_p	YML007C-A	YML007C-A	hom	Uncharacterized	0.322675807860492	0.373470387715234	no	1850	0.383852812557948	1297	NA	FF|FT		MITOCHONDRION		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria	biological_process	molecular_function	mitochondrion
YFR006W_p	YFR006W	YFR006W	hom	Uncharacterized	0.322655115466516	0.373478224049514	no	1851	0.369638928179247	1280	NA					Putative X-Pro aminopeptidase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YFR006W is not an essential gene	biological_process	molecular_function	cytoplasm
YJR154W_p	YJR154W	YJR154W	hom	Uncharacterized	0.322590512349646	0.373502689975783	no	1852	0.388673562510854	1286	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	biological_process	molecular_function	cytoplasm
YDL046W	YDL046W	NPC2	hom	Verified	0.321846329175694	0.373784557248736	no	1853	0.365640207784167	1204	NA					Functional homolog of human NPC2/He1, which is a cholesterol-binding protein whose deficiency causes Niemann-Pick type C2 disease involving retention of cholesterol in lysosomes	intracellular sterol transport	molecular_function	fungal-type vacuole lumen|fungal-type vacuole
YOL085C_d	YOL085C	YOL085C	hom	Dubious	0.321663012944005	0.373854000586417	no	1854	0.37541607405843	1249	NA					Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOL085W-A	Unknown	Unknown	Unknown
YNL073W	YNL073W	MSK1	hom	Verified	0.321518815043132	0.373908628105906	no	1855	0.375178883901358	1241	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION|RNA LOCALIZATION	MITOCHONDRION		Mitochondrial lysine-tRNA synthetase, required for import of both aminoacylated and deacylated forms of tRNA(Lys) into mitochondria and for aminoacylation of mitochondrially encoded tRNA(Lys)	tRNA import into mitochondrion|lysyl-tRNA aminoacylation|mitochondrial lysyl-tRNA aminoacylation|mitochondrial translation	lysine-tRNA ligase activity	mitochondrion
YOR126C	YOR126C	IAH1	hom	Verified	0.321422938280256	0.373944951185871	no	1856	0.356754808488856	1194	NA	FT	KETONE METABOLISM|LIPID METABOLISM			Isoamyl acetate-hydrolyzing esterase, required in balance with alcohol acetyltransferase to maintain optimal amounts of isoamyl acetate, which is particularly important in sake brewing	acetate metabolic process	hydrolase activity, acting on ester bonds	cellular_component
YAR035C-A_p	YAR035C-A	YAR035C-A	hom	Uncharacterized	0.321261892559117	0.374005966159218	no	1857	0.361559235887884	1212	NA					Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; predicted to have a role in cell budding based on computational guilt by association analysis	biological_process	molecular_function	cellular_component
YBL017C	YBL017C	PEP1	hom	Verified	0.321211675530209	0.374024992400025	no	1858	0.352197426126045	1176	NA	FT	PROTEIN LOCALIZATION|VACUOLAR TRANSPORT	GOLGI APPARATUS		Type I transmembrane sorting receptor for multiple vacuolar hydrolases; cycles between the late-Golgi and prevacuolar endosome-like compartments	vacuolar transport|protein targeting to vacuole	signal sequence binding	integral to membrane|Golgi apparatus
YLR123C_d	YLR123C	YLR123C	hom	Dubious	0.321087879276647	0.374071897667133	no	1859	0.348350372615635	1176	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR122C; contains characteristic aminoacyl-tRNA motif	Unknown	Unknown	Unknown
YGL257C	YGL257C	MNT2	hom	Verified	0.320579261128068	0.374264627986542	no	1860	0.379343141724189	1235	NA	FT	CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Mannosyltransferase involved in adding the 4th and 5th mannose residues of O-linked glycans	protein O-linked glycosylation	alpha-1,3-mannosyltransferase activity	cellular_component
YNR033W	YNR033W	ABZ1	hom	Verified	0.320428609827252	0.374321720213659	no	1861	0.359417622027062	1170	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM			Para-aminobenzoate (PABA) synthase; has similarity to Escherichia coli PABA synthase components PabA and PabB; required for the synthesis of para-aminobenzoic acid, an important intermediate for folate and ubiquinone Q biosynthesis; protein abundance increases in response to DNA replication stress	para-aminobenzoic acid biosynthetic process	4-amino-4-deoxychorismate synthase activity	cytoplasm
YLR306W	YLR306W	UBC12	hom	Verified	0.320393162885345	0.374335153919137	no	1862	0.365559916761344	1204	NA					Enzyme that mediates the conjugation of Rub1p, a ubiquitin-like protein, to other proteins; related to E2 ubiquitin-conjugating enzymes	protein neddylation	NEDD8 ligase activity	cellular_component
YIL145C	YIL145C	PAN6	hom	Verified	0.320180441212257	0.374415774523931	no	1863	0.355291914800182	1155	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM	NUCLEUS		Pantothenate synthase, also known as pantoate-beta-alanine ligase, required for pantothenic acid biosynthesis, deletion causes pantothenic acid auxotrophy, homologous to E. coli panC	pantothenate biosynthetic process	pantoate-beta-alanine ligase activity	nucleus|cytoplasm
YKR011C	YKR011C	YKR011C	hom	Verified	0.319848776580502	0.374541484955602	no	1864	0.371083615564005	1204	NA	FT		NUCLEUS		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	nucleus
YML104C	YML104C	MDM1	hom	Verified	0.319819806702853	0.374552466005692	no	1865	0.345039419966246	1137	NA	FT	MITOCHONDRION ORGANIZATION	CYTOSKELETON		Intermediate filament protein, required for nuclear and mitochondrial transmission to daughter buds; contains a Phox homology (PX) domain and specifically binds phosphatidylinositol 3-phosphate (PtdIns-3-P)	nuclear migration|mitochondrion inheritance|mitochondrion organization	structural constituent of cytoskeleton|phosphatidylinositol-3-phosphate binding	intermediate filament|integral to membrane|cytoplasm
YOL124C	YOL124C	TRM11	hom	Verified	0.319240822420708	0.374771951681902	no	1866	0.380494536350041	1245	NA	FT	RNA PROCESSING			Catalytic subunit of an adoMet-dependent tRNA methyltransferase complex (Trm11p-Trm112p), required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs; contains a THUMP domain and a methyltransferase domain	tRNA methylation	S-adenosylmethionine-dependent methyltransferase activity|RNA binding|tRNA (guanine-N2-)-methyltransferase activity	cytoplasm|tRNA (m2G10) methyltransferase complex
YOR044W	YOR044W	IRC23	hom	Verified	0.319099142152372	0.374825667075235	no	1867	0.366790917400203	1226	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Putative protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; null mutant displays increased levels of spontaneous Rad52p foci; IRC23 has a paralog, BSC2, that arose from the whole genome duplication	biological_process	molecular_function	endoplasmic reticulum
YOL065C	YOL065C	INP54	hom	Verified	0.319017966314609	0.374856444452768	no	1868	0.35408925748028	1158	NA	FT	PROTEIN LOCALIZATION|LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Phosphatidylinositol 4,5-bisphosphate 5-phosphatase with a role in secretion, localizes to the endoplasmic reticulum via the C-terminal tail; lacks the Sac1 domain and proline-rich region found in the other 3 INP proteins	phosphatidylinositol dephosphorylation	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	endoplasmic reticulum
YKL160W	YKL160W	ELF1	hom	Verified	0.3183978224446	0.375091594918967	no	1869	0.36132720378886	1196	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION	NUCLEUS		Transcription elongation factor that contains a conserved zinc finger domain; implicated in the maintenance of proper chromatin structure in actively transcribed regions; deletion inhibits Brome mosaic virus (BMV) gene expression	regulation of transcription by chromatin organization|transcription elongation from RNA polymerase II promoter	RNA polymerase II core binding	transcription elongation factor complex|nucleus
YPR200C	YPR200C	ARR2	hom	Verified	0.318028356367851	0.375231713714762	no	1870	0.36933994720313	1224	NA					Arsenate reductase required for arsenate resistance; converts arsenate to arsenite which can then be exported from cells by Arr3p	response to arsenic-containing substance	arsenate reductase activity	cellular_component
YGL149W_d	YGL149W	YGL149W	hom	Dubious	0.317883713526638	0.375286573522765	no	1871	0.366956418484549	1190	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF INO80/YGL150C.	Unknown	Unknown	Unknown
YLR053C_p	YLR053C	YLR053C	hom	Uncharacterized	0.317611488995839	0.375389829064318	no	1872	0.358650135392348	1164	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YDR446W	YDR446W	ECM11	hom	Verified	0.31759665705885	0.375395455116885	no	1873	0.348440302493227	1140	NA	FT	CELL CYCLE|CELL WALL ORG/BIOGENESIS	NUCLEUS		Non-essential protein apparently involved in meiosis, GFP fusion protein is present in discrete clusters in the nucleus throughout mitosis; may be involved in maintaining chromatin structure	fungal-type cell wall organization|reciprocal meiotic recombination	molecular_function	nucleus
YBL007C	YBL007C	SLA1	hom	Verified	0.317550151191687	0.375413095901227	no	1874	0.407367244947822	1325	NA	FF|FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION	NUCLEUS|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON		Cytoskeletal protein binding protein required for assembly of the cortical actin cytoskeleton; interacts with proteins regulating actin dynamics and proteins required for endocytosis; found in the nucleus and cell cortex; has 3 SH3 domains	fungal-type cell wall organization|endocytosis|actin cortical patch assembly	ubiquitin binding|protein binding, bridging	cell cortex|nucleus|mating projection tip|actin cortical patch
YMR158W	YMR158W	MRPS8	hom	Verified	0.317523650492	0.37542314836505	no	1875	0.376498143237722	1241	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the small subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YNL273W	YNL273W	TOF1	hom	Verified	0.317146493046698	0.375566224001212	no	1876	0.374546337057284	1218	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME		Subunit of a replication-pausing checkpoint complex (Tof1p-Mrc1p-Csm3p) that acts at the stalled replication fork to promote sister chromatid cohesion after DNA damage, facilitating gap repair of damaged DNA; interacts with the MCM helicase	DNA repair|DNA replication checkpoint|maintenance of DNA repeat elements|replication fork arrest|replication fork protection|DNA replication|mitotic sister chromatid cohesion	molecular_function	nuclear chromosome|replication fork protection complex|nuclear replication fork
YER046W	YER046W	SPO73	hom	Verified	0.316746258445912	0.375718072732343	no	1877	0.367401219568852	1227	NA	FT	CELL WALL ORG/BIOGENESIS			Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensible for both nuclear divisions during meiosis	ascospore wall assembly|ascospore formation	molecular_function	cytosol
YDL021W	YDL021W	GPM2	hom	Verified	0.316371869363343	0.375860133119013	no	1878	0.383129799924707	1267	NA	FT	CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY			Homolog of Gpm1p phosphoglycerate mutase, which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event	biological_process	phosphoglycerate mutase activity|molecular_function	cytosol|cytoplasm
YKR106W	YKR106W	GEX2	hom	Verified	0.316358740765952	0.375865115016408	no	1879	0.362715038408526	1206	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Proton:glutathione antiporter localized to the vacuolar and plasma membranes; expressed at a very low level; almost identical to paralog Gex1p; potential role in resistance to oxidative stress and modulation of the PKA pathway	glutathione transmembrane transport	solute:hydrogen antiporter activity	integral to membrane|plasma membrane|vacuolar membrane
YOR050C_d	YOR050C	YOR050C	hom	Dubious	0.316160915652399	0.375940186044107	no	1880	0.360029420599336	1203	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutation is viable	Unknown	Unknown	Unknown
YJL166W	YJL166W	QCR8	hom	Verified	0.315672880375967	0.376125406617902	no	1881	0.367896492572837	1199	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p	mitochondrial electron transport, ubiquinol to cytochrome c|aerobic respiration	ubiquinol-cytochrome-c reductase activity	mitochondrion|integral to membrane|mitochondrial respiratory chain complex III
YLL053C_p	YLL053C	YLL053C	hom	Uncharacterized	0.315525990835878	0.376181160154243	no	1882	0.363695766581692	1212	NA					Putative protein; in the Sigma 1278B strain background YLL053C is contiguous with AQY2 which encodes an aquaporin	biological_process	molecular_function	integral to membrane
YHR210C_p	YHR210C	YHR210C	hom	Uncharacterized	0.315219839934629	0.376297371391642	no	1883	0.37910940780454	1266	NA	FT	CARBOHYDRATE METABOLISM			Putative aldose 1-epimerase superfamily protein; non-essential gene; highly expressed under anaeorbic conditions	biological_process	molecular_function	cellular_component
YKL006W	YKL006W	RPL14A	hom	Verified	0.315214279208863	0.376299482280678	no	1884	0.39238879778199	1285	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L14A; N-terminally acetylated; homologous to mammalian ribosomal protein L14, no bacterial homolog; RPL14A has a paralog, RPL14B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome|RNA binding	cytosolic large ribosomal subunit
YMR205C	YMR205C	PFK2	hom	Verified	0.315172186881242	0.376315460932368	no	1885	0.499811363581723	1680	NA	FT	CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Beta subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes	proton transport|glycolysis	mRNA binding|6-phosphofructokinase activity	mitochondrion|6-phosphofructokinase complex|cytoplasm
YCL005W-A	YCL005W-A	VMA9	hom	Verified	0.313877742984428	0.376806947635561	no	1886	0.401437395910311	1311	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|CELL WALL ORG/BIOGENESIS|ION HOMEOSTASIS			Vacuolar H+ ATPase subunit e of the V-ATPase V0 subcomplex; essential for vacuolar acidification; interacts with the V-ATPase assembly factor Vma21p in the ER; involved in V0 biogenesis	cell wall mannoprotein biosynthetic process|vacuolar acidification|protein complex assembly|transmembrane transport	ATPase activity, coupled to transmembrane movement of ions	vacuolar proton-transporting V-type ATPase, V0 domain|fungal-type vacuole membrane
YJR034W	YJR034W	PET191	hom	Verified	0.313100599501211	0.377102116823467	no	1887	0.385665337695556	1273	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Protein required for assembly of cytochrome c oxidase; exists as an oligomer; described as both an integral mitochondrial inner membrane protein facing the intermembrane space (IMS) and as a soluble IMS protein; contains a twin Cx9C motif; imported into the IMS via the MIA import machinery	mitochondrial respiratory chain complex IV assembly	molecular_function	mitochondrion|integral to mitochondrial inner membrane
YIL119C	YIL119C	RPI1	hom	Verified	0.31307842690957	0.377110539316427	no	1888	0.358627225637152	1195	NA	FT	SIGNALING	NUCLEUS		Transcription factor with allelic differences between S288C and Sigma1278b; mediates fermentation stress tolerance by modulating cell wall integrity; overexpression suppresses heat shock sensitivity of wild-type RAS2 overexpression and also suppresses cell lysis defect of mpk1 mutation; allele from S288c can confer fMAPK pathway independent transcription of FLO11; S288C and Sigma1278b alleles differ in number of tandem repeats within ORF	fungal-type cell wall biogenesis|Ras protein signal transduction|positive regulation of transcription from RNA polymerase II promoter	small GTPase regulator activity	nucleus
YCR022C_d	YCR022C	YCR022C	hom	Dubious	0.313048343027937	0.377121967089873	no	1889	0.371629413766837	1218	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR022C is not an essential gene	Unknown	Unknown	Unknown
YJR055W	YJR055W	HIT1	hom	Verified	0.312616458132175	0.377286036326305	no	1890	0.318945633958201	1080	NA	FT		NUCLEUS		Protein of unknown function, required for growth at high temperature	biological_process	molecular_function	nucleus|cytoplasm
YGR250C	YGR250C	YGR250C	hom	Verified	0.312516909612004	0.377323857067678	no	1891	0.3796836431322	1248	NA					Putative RNA binding protein; localizes to stress granules induced by glucose deprivation; interacts with Rbg1p in a two-hybrid assay; protein abundance increases in response to DNA replication stress	biological_process	RNA binding	cytoplasmic stress granule|cytoplasm
YJR010W	YJR010W	MET3	hom	Verified	0.311142208763966	0.377846257277747	no	1892	0.388887212924197	1292	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		ATP sulfurylase, catalyzes the primary step of intracellular sulfate activation, essential for assimilatory reduction of sulfate to sulfide, involved in methionine metabolism	sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)|sulfur amino acid metabolic process	sulfate adenylyltransferase (ATP) activity	mitochondrion|cytoplasm
YGL006W-A_p	YGL006W-A	YGL006W-A	hom	Uncharacterized	0.310863690257951	0.377952124379729	no	1893	0.36199273788378	1227	NA					Putative protein of unknown function; identified by SAGE	biological_process	molecular_function	cellular_component
YBR144C_d	YBR144C	YBR144C	hom	Dubious	0.310784766041325	0.377982125770062	no	1894	0.362388310826876	1182	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR144C is not an essential gene	Unknown	Unknown	Unknown
YGR121C	YGR121C	MEP1	hom	Verified	0.30977246774199	0.378366994989481	no	1895	0.361264746919897	1211	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Ammonium permease; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation	nitrogen utilization|ammonium transport	ammonium transmembrane transporter activity	integral to membrane|plasma membrane
YLR112W_d	YLR112W	YLR112W	hom	Dubious	0.309315853296673	0.378540636351718	no	1896	0.365135348395609	1180	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YBR182C	YBR182C	SMP1	hom	Verified	0.30869959712991	0.378775025157014	no	1897	0.363924395149569	1204	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Putative transcription factor of the MADS-box family; involved in regulating the response to osmotic stress; SMP1 has a paralog, RLM1, that arose from the whole genome duplication	positive regulation of transcription from RNA polymerase II promoter in response to osmotic stress	DNA binding, bending|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	nucleus|cytoplasm
YER099C	YER099C	PRS2	hom	Verified	0.308697273732259	0.378775908929803	no	1898	0.354433094369923	1185	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM			5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; PRS2 has a paralog, PRS4, that arose from the whole genome duplication	fungal-type cell wall organization|5-phosphoribose 1-diphosphate biosynthetic process	ribose phosphate diphosphokinase activity	cytoplasm
YGR112W	YGR112W	SHY1	hom	Verified	0.307525697095701	0.379221633294494	no	1899	0.367702937284434	1232	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Mitochondrial inner membrane protein required for assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes; similar to human SURF1 involved in Leigh Syndrome	mitochondrial respiratory chain complex IV assembly|aerobic respiration	unfolded protein binding	mitochondrion|integral to membrane|mitochondrial inner membrane
YBR273C	YBR273C	UBX7	hom	Verified	0.306854626054531	0.379477013530738	no	1900	0.3722828015462	1236	NA	FT	PROTEOLYSIS	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM		UBX (ubiquitin regulatory X) domain-containing protein; interacts with Cdc48p; UBX7 has a paralog, UBX6, that arose from the whole genome duplication	sporulation resulting in formation of a cellular spore|ubiquitin-dependent protein catabolic process	molecular_function	nuclear envelope|endoplasmic reticulum
YFL013W-A_d	YFL013W-A	YFL013W-A	hom	Dubious	0.306661924834306	0.379550356896433	no	1901	0.395329594447669	1310	NA					Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps IES1/YFL013C; identified by gene-trapping, microarray expression analysis, and genome-wide homology searching	Unknown	Unknown	Unknown
YBL096C_d	YBL096C	YBL096C	hom	Dubious	0.306423284625901	0.379641190953571	no	1902	0.371809116949319	1229	NA					Non-essential protein of unknown function	Unknown	Unknown	Unknown
YER187W_p	YER187W	YER187W	hom	Uncharacterized	0.306034236206462	0.379789289401549	no	1903	0.366742686455118	1230	NA					Putative protein of unknown function; induced in respiratory-deficient cells	biological_process	molecular_function	cellular_component
YLR034C	YLR034C	SMF3	hom	Verified	0.305414796161044	0.380025127048067	no	1904	0.376790929363927	1250	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Putative divalent metal ion transporter involved in iron homeostasis; transcriptionally regulated by metal ions; member of the Nramp family of metal transport proteins; protein abundance increases in response to DNA replication stress	cellular iron ion homeostasis|iron ion transport	metal ion transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane
YKL040C	YKL040C	NFU1	hom	Verified	0.304323737449298	0.380440631191283	no	1905	0.367195209867693	1222	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|COFACTOR METABOLISM	MITOCHONDRION		Protein involved in iron metabolism in mitochondria; similar to NifU, which is a protein required for the maturation of the Fe/S clusters of nitrogenase in nitrogen-fixing bacteria	cellular iron ion homeostasis|iron-sulfur cluster assembly|intracellular sequestering of iron ion	molecular_function	mitochondrion|mitochondrial matrix
YKL183W	YKL183W	LOT5	hom	Verified	0.303764034254603	0.380653834614055	no	1906	0.368685844894403	1226	NA	FT		NUCLEUS		Protein of unknown function; gene expression increases in cultures shifted to a lower temperature; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	nucleus|cytoplasm
YGL248W	YGL248W	PDE1	hom	Verified	0.303745925056492	0.380660733417033	no	1907	0.372204577291496	1226	NA	FT	SIGNALING|NUCLEOTIDE METABOLISM			Low-affinity cyclic AMP phosphodiesterase, controls glucose and intracellular acidification-induced cAMP signaling, target of the cAMP-protein kinase A (PKA) pathway; glucose induces transcription and inhibits translation	cAMP-mediated signaling	3',5'-cyclic-AMP phosphodiesterase activity	cellular_component
YFR011C	YFR011C	AIM13	hom	Verified	0.303603184660673	0.380715112518451	no	1908	0.370888739632927	1224	NA	FT	MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial protein peripheral to the inner membrane; component of the mitochondrial inner membrane organizing system (MINOS, MitOS, or MICOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture	cristae formation	molecular_function	mitochondrion|extrinsic to mitochondrial inner membrane|mitochondrial crista junction|cytoplasm|mitochondrial intermembrane space
YPR156C	YPR156C	TPO3	hom	Verified	0.303490174191791	0.380758167228444	no	1909	0.371400414055138	1220	NA	FT		PLASMA MEMBRANE		Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; specific for spermine; localizes to the plasma membrane; TPO3 has a paralog, TPO2, that arose from the whole genome duplication	spermine transport	spermine transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane|plasma membrane
YGL140C_p	YGL140C	YGL140C	hom	Uncharacterized	0.303421249792301	0.380784426759905	no	1910	0.344981213234904	1156	NA					Putative protein of unknown function; non-essential gene; contains multiple predicted transmembrane domains	biological_process	molecular_function	integral to membrane
YLR164W	YLR164W	SHH4	hom	Verified	0.303372509454072	0.380802996690188	no	1911	0.356826501072552	1199	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Mitochondrial inner membrane protein of unknown function; similar to Tim18p and Sdh4p; a fraction copurifies with Sdh3p, but Shh4p is neither a stoichiometric subunit of succinate dehydrogenase nor of the TIM22 translocase; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner	biological_process	molecular_function	mitochondrion|mitochondrial inner membrane
YDR377W	YDR377W	ATP17	hom	Verified	0.303120643505824	0.380898961275067	no	1912	0.401336354641946	1308	NA	FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS	MITOCHONDRION		Subunit f of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis	ATP synthesis coupled proton transport	hydrogen ion transporting ATP synthase activity, rotational mechanism|ATPase activity|proton-transporting ATPase activity, rotational mechanism	mitochondrion|mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
YOL077W-A	YOL077W-A	ATP19	hom	Verified	0.302196352367021	0.381251192362495	no	1913	0.3704254428648	1268	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS	MITOCHONDRION		Subunit k of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; associated only with the dimeric form of ATP synthase	mitochondrial proton-transporting ATP synthase complex assembly|ATP synthesis coupled proton transport	hydrogen ion transporting ATP synthase activity, rotational mechanism	mitochondrion|mitochondrial proton-transporting ATP synthase complex|mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
YAL049C	YAL049C	AIM2	hom	Verified	0.302159971961276	0.381265058309407	no	1914	0.378452765559233	1257	NA					Cytoplasmic protein involved in mitochondrial function or organization; null mutant displays reduced frequency of mitochondrial genome loss; potential Hsp82p interactor	biological_process	molecular_function	cytoplasm
YIR042C_p	YIR042C	YIR042C	hom	Uncharacterized	0.30178414921448	0.381408307472444	no	1915	0.372871252781378	1217	NA					Putative protein of unknown function; YIR042C is a non-essential gene	biological_process	molecular_function	cellular_component
YHR014W	YHR014W	SPO13	hom	Verified	0.301462575314754	0.381530891963236	no	1916	0.361343025988047	1173	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME		Meiosis-specific protein, involved in maintaining sister chromatid cohesion during meiosis I as well as promoting proper attachment of kinetochores to the spindle during meiosis I and meiosis II	protein localization to chromosome, centromeric region|meiotic sister chromatid cohesion|positive regulation of sister chromatid cohesion	molecular_function	nucleus|condensed nuclear chromosome, centromeric region
YKL168C	YKL168C	KKQ8	hom	Verified	0.300127228494405	0.382040055339655	no	1917	0.376310389526226	1237	NA	FT	PROTEIN PHOSPHORYLATION			Putative serine/threonine protein kinase with unknown cellular role; KKQ8 has a paralog, HAL5, that arose from the whole genome duplication	biological_process	protein kinase activity	cytoplasm
YLR348C	YLR348C	DIC1	hom	Verified	0.300105972644303	0.382048161778266	no	1918	0.376882362190346	1219	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Mitochondrial dicarboxylate carrier, integral membrane protein, catalyzes a dicarboxylate-phosphate exchange across the inner mitochondrial membrane, transports cytoplasmic dicarboxylates into the mitochondrial matrix	dicarboxylic acid transport	dicarboxylic acid transmembrane transporter activity	mitochondrial envelope|mitochondrion|integral to membrane
YKL134C	YKL134C	OCT1	hom	Verified	0.299654426912019	0.38222038200561	no	1919	0.375121438724898	1225	NA	FT	PROTEIN LOCALIZATION|ION HOMEOSTASIS|PROTEOLYSIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS	MITOCHONDRION		Mitochondrial intermediate peptidase, cleaves destabilizing N-terminal residues of a subset of proteins upon import, after their cleavage by mitochondrial processing peptidase (Mas1p-Mas2p); may contribute to mitochondrial iron homeostasis	cellular iron ion homeostasis|protein processing involved in protein targeting to mitochondrion	metalloendopeptidase activity	mitochondrion
YIL161W_p	YIL161W	YIL161W	hom	Uncharacterized	0.299316288486235	0.382349363775811	no	1920	0.370919341467063	1233	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; mRNA is enriched in Scp160p-associated mRNPs; YIL161W is a non-essential gene	biological_process	molecular_function	cytoplasm
YCL027W	YCL027W	FUS1	hom	Verified	0.298918565976033	0.382501090402768	no	1921	0.360628389189925	1192	NA	FT	PROTEIN LOCALIZATION	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Membrane protein localized to the shmoo tip, required for cell fusion; expression regulated by mating pheromone; proposed to coordinate signaling, fusion, and polarization events required for fusion; potential Cdc28p substrate	regulation of termination of mating projection growth|cytogamy|cortical protein anchoring	molecular_function	integral to plasma membrane|mating projection tip
YBR043C	YBR043C	QDR3	hom	Verified	0.298473218565932	0.3826710067967	no	1922	0.357569109517259	1228	NA	FT		PLASMA MEMBRANE		Multidrug transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; has a role in polyamine homeostasis; expression is upregulated under polyamine stress; required for resistance to quinidine, barban, cisplatin, and bleomycin	drug transmembrane transport|polyamine homeostasis	drug transmembrane transporter activity|polyamine transmembrane transporter activity	integral to membrane|plasma membrane
YLR137W	YLR137W	RKM5	hom	Verified	0.298429689468696	0.382687615958321	no	1923	0.370568102063995	1224	NA					Protein lysine methyltransferase; monomethylates Lys-46 of the ribosomal large subunit Rpl1a/Rpl1b; member of the seven beta-strand methyltransferase superfamily; orthologs only found among fungal species	protein methylation	S-adenosylmethionine-dependent methyltransferase activity	cellular_component
YGL175C	YGL175C	SAE2	hom	Verified	0.298420634815365	0.382691070920408	no	1924	0.363848775647656	1202	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS		Endonuclease that processes hairpin DNA structures with the MRX complex; involved in meiotic and mitotic double-strand break repair; phosphorylated in response to DNA damage and required for normal resistance to DNA-damaging agents	DNA double-strand break processing|DNA catabolic process, endonucleolytic|meiotic DNA double-strand break formation|meiotic DNA double-strand break processing|gene conversion at mating-type locus, DNA double-strand break processing	double-stranded DNA binding|single-stranded DNA specific endodeoxyribonuclease activity	nucleus|cytoplasm
YNL201C	YNL201C	PSY2	hom	Verified	0.297737032198159	0.382951938451132	no	1925	0.430678958836615	1417	NA	FT	CELL CYCLE|SIGNALING|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Subunit of protein phosphatase PP4 complex; active complex is composed of catalytic subunit Pph3p and Psy2p, with Psy4p apparently providing additional substrate specificity in some cases; regulates recovery from the DNA damage checkpoint and also the gene conversion- and single-strand annealing-mediated pathways of meiotic double-strand break repair; Pph3p and Psy2p localize to foci on meiotic chromosomes; putative homolog of mammalian R3	Unknown|response to DNA damage stimulus|protein dephosphorylation|signal transduction involved in meiotic recombination checkpoint	protein serine/threonine phosphatase activity	condensed nuclear chromosome|nucleus
YDR155C	YDR155C	CPR1	hom	Verified	0.297317012262661	0.383112247333861	no	1926	0.394148927267249	1310	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|CHROMATIN ORGANIZATION	NUCLEUS|MITOCHONDRION|CHROMOSOME		Cytoplasmic peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds the drug cyclosporin A; protein abundance increases in response to DNA replication stress	cellular protein metabolic process|ascospore formation|positive regulation of meiosis|histone deacetylation	peptidyl-prolyl cis-trans isomerase activity|cyclosporin A binding	histone deacetylase complex|mitochondrion|Set3 complex|nucleus
YDR256C	YDR256C	CTA1	hom	Verified	0.297069974968045	0.383206543336012	no	1927	0.378554533173942	1236	NA	FT	OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS	MITOCHONDRION		Catalase A, breaks down hydrogen peroxide in the peroxisomal matrix formed by acyl-CoA oxidase (Pox1p) during fatty acid beta-oxidation	response to reactive oxygen species|age-dependent response to reactive oxygen species|hydrogen peroxide catabolic process	catalase activity	peroxisomal matrix|mitochondrial matrix
YGL131C	YGL131C	SNT2	hom	Verified	0.296502498842545	0.383423179460031	no	1928	0.379726480794884	1253	NA	FT		NUCLEUS|CHROMOSOME		DNA binding protein with similarity to the S. pombe Snt2 protein; RING finger ubiquitin ligase (E3) involved in ubiquitylation and degradation of excess histones; interacts with Ubc4p; null mutant sensitive to hydroxyurea (HU); computational analysis suggests that Snt2p is a transcription factor with a role in regulation of expression of genes encoding amine transporters; relocalizes from nucleus to cytoplasm upon DNA replication stress	biological_process	DNA binding	nucleus|Snt2C complex|cytoplasm
YDR135C	YDR135C	YCF1	hom	Verified	0.295955443315446	0.383632054455057	no	1929	0.363427674508474	1208	NA	FT	NUCLEOTIDE METABOLISM			Vacuolar glutathione S-conjugate transporter; member of the ATP-binding cassette family; has a role in detoxifying metals such as cadmium, mercury, and arsenite; also transports unconjugated bilirubin, selenodigluthatione, and oxidized glutathione; similar to human cystic fibrosis protein CFTR	bilirubin transport|response to metal ion|transmembrane transport	bilirubin transmembrane transporter activity|glutathione S-conjugate-exporting ATPase activity	fungal-type vacuole membrane|integral to membrane
YGR077C	YGR077C	PEX8	hom	Verified	0.295781864912657	0.383698336677425	no	1930	0.333200926396907	1132	NA	FT	PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION			Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p	protein targeting to peroxisome|peroxisome organization	peroxisome targeting sequence binding	peroxisomal matrix|peroxisomal membrane|extrinsic to intraperoxisomal membrane
YER056C	YER056C	FCY2	hom	Verified	0.295593284068287	0.383770351552226	no	1931	0.35350958029893	1150	NA	FT		PLASMA MEMBRANE		Purine-cytosine permease; mediates purine (adenine, guanine, and hypoxanthine) and cytosine accumulation; relative distribution to the vacuole increases upon DNA replication stress	cytosine transport|cytidine transport|purine nucleobase transport|transmembrane transport	nucleobase transmembrane transporter activity|cytidine transmembrane transporter activity	integral to membrane|plasma membrane
YHL014C	YHL014C	YLF2	hom	Verified	0.295121711991045	0.383950452117503	no	1932	0.385638929948747	1301	NA	FT		MITOCHONDRION		Protein of unknown function, has weak similarity to E. coli GTP-binding protein gtp1; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	GTP binding	mitochondrion
YDR480W	YDR480W	DIG2	hom	Verified	0.294750693698163	0.384092167280405	no	1933	0.371252899462604	1228	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		MAP kinase-responsive inhibitor of the Ste12p transcription factor, involved in the regulation of mating-specific genes and the invasive growth pathway; related regulators Dig1p and Dig2p bind to Ste12p	negative regulation of transcription from RNA polymerase II promoter by pheromones|Unknown	transcription factor binding	nucleus
YKR054C	YKR054C	DYN1	hom	Verified	0.294687926691324	0.38411614347143	no	1934	0.348267480971358	1145	NA	FT	CELL CYCLE|NUCLEOTIDE METABOLISM|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION	CYTOSKELETON		Cytoplasmic heavy chain dynein, microtubule motor protein, required for anaphase spindle elongation; involved in spindle assembly, chromosome movement, and spindle orientation during cell division, targeted to microtubule tips by Pac1p	nuclear migration along microtubule|establishment of mitotic spindle orientation|mitotic spindle elongation|mitotic sister chromatid segregation	microtubule motor activity	cytoplasmic dynein complex|cell cortex|cytoplasmic microtubule|spindle pole body|astral microtubule
YNL194C	YNL194C	YNL194C	hom	Verified	0.294487661566674	0.384192645143138	no	1935	0.376414798195339	1253	NA	FT		ENDOPLASMIC RETICULUM|PLASMA MEMBRANE		Integral membrane protein required for sporulation and plasma membrane sphingolipid content; has sequence similarity to SUR7 and FMP45; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; GFP-fusion protein is more abundant at MCCs (membrane compartment occupied by Can1) in the presence of glycerol and oleate	ascospore formation	molecular_function	cell cortex|integral to membrane|endoplasmic reticulum|plasma membrane|cytoplasm
YOL153C	YOL153C	YOL153C	hom	pseudogene	0.29352860585888	0.384559068802459	no	1936	0.363990832999137	1233	NA					Hypothetical protein	biological_process	molecular_function	cellular_component
YAR015W	YAR015W	ADE1	hom	Verified	0.293223266037256	0.384675750777166	no	1937	0.381760742690725	1232	NA	FT	NUCLEOTIDE METABOLISM	NUCLEUS		N-succinyl-5-aminoimidazole-4-carboxamide ribotide (SAICAR) synthetase, required for 'de novo' purine nucleotide biosynthesis; red pigment accumulates in mutant cells deprived of adenine; protein abundance increases in response to DNA replication stress	purine nucleotide biosynthetic process|'de novo' IMP biosynthetic process	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity	nucleus|cytoplasm
YOL045W	YOL045W	PSK2	hom	Verified	0.292924059504072	0.384790099123492	no	1938	0.396866464661457	1299	NA	FT	SIGNALING|TRANSLATION|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		PAS-domain containing serine/threonine protein kinase; regulates sugar flux and translation in response to an unknown metabolite by phosphorylating Ugp1p and Gsy2p (sugar flux) and Caf20p, Tif11p and Sro9p (translation); PSK2 has a paralog, PSK1, that arose from the whole genome duplication	regulation of (1->6)-beta-D-glucan biosynthetic process|negative regulation of glycogen biosynthetic process|protein phosphorylation	protein serine/threonine kinase activity	mitochondrion|cytoplasm
YDR215C_d	YDR215C	YDR215C	hom	Dubious	0.292891257155712	0.384802635870945	no	1939	0.389349989127405	1277	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays elevated sensitivity to expression of a mutant huntingtin fragment or of alpha-synuclein	Unknown	Unknown	Unknown
YGL054C	YGL054C	ERV14	hom	Verified	0.29277841583485	0.384845763676831	no	1940	0.471563992447366	1560	NA	FF|FT	VESICLE-MEDIATED TRANSPORT|CELL CYCLE|SIGNALING|CELL DIVISION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		COPII-coated vesicle protein; involved in vesicle formation and incorporation of specific secretory cargo; required for the delivery of bud-site selection protein Axl2p to cell surface; related to Drosophila cornichon; ERV14 has a paralog, ERV15, that arose from the whole genome duplication	ascospore formation|ER to Golgi vesicle-mediated transport|axial cellular bud site selection	molecular_function	integral to membrane|ER to Golgi transport vesicle|endoplasmic reticulum membrane
YKL068W	YKL068W	NUP100	hom	Verified	0.292186927667967	0.385071852981535	no	1941	0.372434437573724	1250	NA	FT	PROTEIN LOCALIZATION|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier and is involved in gene tethering at the nuclear periphery; homologous to Nup116p	positive regulation of transcription, DNA-dependent|mRNA export from nucleus|NLS-bearing substrate import into nucleus|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|protein import into nucleus|protein targeting to nuclear inner membrane|mRNA export from nucleus in response to heat stress	nucleocytoplasmic transporter activity|structural constituent of nuclear pore	nuclear pore central transport channel|integral to membrane|nuclear pore
YLR368W	YLR368W	MDM30	hom	Verified	0.291163255940503	0.385463231599096	no	1942	0.373596448354324	1250	NA	FT	MEMBRANE ORGANIZATION|PROTEOLYSIS|MITOCHONDRION ORGANIZATION|RNA LOCALIZATION	MITOCHONDRION	UBIQUITIN LIGASE COMPLEX	F-box component of an SCF ubiquitin protein ligase complex; associates with and is required for Fzo1p ubiquitination and for mitochondria fusion; stimulates nuclear export of specific mRNAs; promotes ubiquitin-mediated degradation of Gal4p in some strains	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|chronological cell aging|proteolysis involved in cellular protein catabolic process|mitochondrion organization|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of mRNA export from nucleus|mitochondrial fusion	ubiquitin-protein ligase activity	mitochondrion|SCF ubiquitin ligase complex
YPR138C	YPR138C	MEP3	hom	Verified	0.290132318838002	0.385857505888839	no	1943	0.382806136360551	1261	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Ammonium permease of high capacity and low affinity; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation ammonia permease	nitrogen utilization|ammonium transport	ammonium transmembrane transporter activity	integral to membrane|plasma membrane
YDR441C	YDR441C	APT2	hom	Verified	0.289149791428466	0.386233376024796	no	1944	0.38456530169426	1259	NA					Potential adenine phosphoribosyltransferase; encodes a protein with similarity to adenine phosphoribosyltransferase, but artificially expressed protein exhibits no enzymatic activity; APT2 has a paralog, APT1, that arose from the whole genome duplication	biological_process	adenine phosphoribosyltransferase activity|molecular_function	cytoplasm
YPR193C	YPR193C	HPA2	hom	Verified	0.289005199053102	0.386288699490108	no	1945	0.37321289664127	1243	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CHROMATIN ORGANIZATION			Tetrameric histone acetyltransferase with similarity to Gcn5p, Hat1p, Elp3p, and Hpa3p; acetylates histones H3 and H4 in vitro and exhibits autoacetylation activity	protein homotetramerization|histone acetylation	histone acetyltransferase activity|protein homodimerization activity	cytoplasm
YPR075C	YPR075C	OPY2	hom	Verified	0.288638444090158	0.386429036450191	no	1946	0.377648752958283	1253	NA	FT	CELL CYCLE|SIGNALING	PLASMA MEMBRANE		Integral membrane protein that acts as a membrane anchor for Ste50p; involved in the signaling branch of the high-osmolarity glycerol (HOG) pathway and as a regulator of the filamentous growth pathway; overproduction blocks cell cycle arrest in the presence of mating pheromone; relocalizes from vacuole to plasma membrane upon DNA replication stress	cell cycle arrest in response to pheromone|osmosensory signaling pathway	molecular_function	integral to membrane|plasma membrane|fungal-type vacuole|cytoplasm
YMR007W_d	YMR007W	YMR007W	hom	Dubious	0.287452893853352	0.386882782890292	no	1947	0.362861118791348	1208	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YHR095W_d	YHR095W	YHR095W	hom	Dubious	0.287219977271917	0.386971945405752	no	1948	0.38816511877316	1276	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YOL088C	YOL088C	MPD2	hom	Verified	0.287024039034793	0.387046956905698	no	1949	0.44476214989792	1434	NA	FT		ENDOPLASMIC RETICULUM		Member of the protein disulfide isomerase (PDI) family, exhibits chaperone activity; overexpression suppresses the lethality of a pdi1 deletion but does not complement all Pdi1p functions; undergoes oxidation by Ero1p	protein folding	protein disulfide isomerase activity|protein disulfide oxidoreductase activity	endoplasmic reticulum
YDR111C_p	YDR111C	ALT2	hom	Uncharacterized	0.286847716024086	0.387114462668411	no	1950	0.383297536539079	1243	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Catalytically inactive paralog of ALT1, an alanine transaminase; expression is repressed in the presence of alanine and repression is mediated by Nrg1p	biological_process	transaminase activity	nucleus|cytoplasm
YNL166C	YNL166C	BNI5	hom	Verified	0.286351008857483	0.387304646760828	no	1951	0.373906189553553	1236	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner	septin ring assembly|cytokinesis	molecular_function	cellular bud neck septin ring|cellular bud neck
YER158C_p	YER158C	YER158C	hom	Uncharacterized	0.285820723200416	0.387507717569947	no	1952	0.374417344869823	1253	NA					Protein of unknown function; potentially phosphorylated by Cdc28p; YER158C has a paralog, AFR1, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YLL009C	YLL009C	COX17	hom	Verified	0.285218180332837	0.38773849634931	no	1953	0.381931585883117	1247	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS	MITOCHONDRION		Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs	mitochondrial respiratory chain complex IV assembly|intracellular copper ion transport	copper chaperone activity	cytosol|mitochondrion|mitochondrial intermembrane space
YOL129W	YOL129W	VPS68	hom	Verified	0.282792451812957	0.388667970419671	no	1954	0.394366191164313	1309	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	MITOCHONDRION		Vacuolar membrane protein of unknown function involved in vacuolar protein sorting; also detected in the mitochondria	late endosome to vacuole transport via multivesicular body sorting pathway|protein targeting to vacuole	molecular_function	Vps55/Vps68 complex|mitochondrion|fungal-type vacuole membrane|integral to membrane
YLR299W	YLR299W	ECM38	hom	Verified	0.282405100082713	0.388816452394745	no	1955	0.364575101615405	1183	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Gamma-glutamyltranspeptidase, major glutathione-degrading enzyme; involved in detoxification of electrophilic xenobiotics; expression induced mainly by nitrogen starvation	xenobiotic metabolic process|glutathione catabolic process	gamma-glutamyltransferase activity	fungal-type vacuole
YFR041C	YFR041C	ERJ5	hom	Verified	0.28193694930941	0.388995928418034	no	1956	0.372869309604212	1214	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Type I membrane protein with a J domain is required to preserve the folding capacity of the endoplasmic reticulum; loss of the non-essential ERJ5 gene leads to a constitutively induced unfolded protein response	protein folding	molecular_function	endoplasmic reticulum
YMR136W	YMR136W	GAT2	hom	Verified	0.281901402573515	0.389009557018917	no	1957	0.388530064486914	1247	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Protein containing GATA family zinc finger motifs; similar to Gln3p and Dal80p; expression repressed by leucine	regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding RNA polymerase II transcription factor activity	nucleus
YPR032W	YPR032W	SRO7	hom	Verified	0.28094434502111	0.389376543695095	no	1958	0.383550240875317	1258	NA	FT	VESICLE-MEDIATED TRANSPORT|SIGNALING	PLASMA MEMBRANE		Effector of Rab GTPase Sec4p; forms a complex with Sec4p and t-SNARE Sec9p; involved in exocytosis and docking and fusion of post-Golgi vesicles with plasma membrane; homolog of Drosophila lgl tumor suppressor; SRO7 has a paralog, SRO77, that arose from the whole genome duplication	establishment of cell polarity|exocytosis|Golgi to plasma membrane transport|small GTPase mediated signal transduction	SNARE binding|Rab GTPase binding	cytosol|plasma membrane
YHR129C	YHR129C	ARP1	hom	Verified	0.280386629895389	0.389590446814951	no	1959	0.393207216994054	1309	NA	FT	CELL CYCLE|CYTOSKELETON ORGANIZATION	CYTOSKELETON		Actin-related protein of the dynactin complex; required for spindle orientation and nuclear migration; putative ortholog of mammalian centractin	nuclear migration|establishment of mitotic spindle orientation	structural constituent of cytoskeleton	cell cortex|dynactin complex|spindle pole body|astral microtubule
YGR104C	YGR104C	SRB5	hom	Verified	0.278823605794676	0.39019009888983	no	1960	0.405752756420503	1334	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS	RNA POL II, HOLOENZYME	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; required for proper termination of transcription for some genes; involved in telomere maintenance	transcriptional open complex formation at RNA polymerase II promoter|RNA polymerase II transcriptional preinitiation complex assembly|positive regulation of transcription from RNA polymerase II promoter	core RNA polymerase II binding transcription factor activity|RNA polymerase II transcription factor recruiting transcription factor activity|TBP-class protein binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly	core mediator complex
YOR369C	YOR369C	RPS12	hom	Verified	0.278252265167287	0.390409358254062	no	1961	0.378145055758124	1232	NA	FT	TRANSLATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S12, no bacterial homolog	cytoplasmic translation	structural constituent of ribosome	cytosolic small ribosomal subunit
YDR415C_p	YDR415C	YDR415C	hom	Uncharacterized	0.277711739202995	0.390616824183822	no	1962	0.371960440020118	1237	NA	FT	PROTEOLYSIS			Putative aminopeptidase	biological_process	molecular_function	cellular_component
YCR101C_p	YCR101C	YCR101C	hom	Uncharacterized	0.277628849794403	0.390648641744598	no	1963	0.391346475772365	1315	NA					Putative protein of unknown function; localizes to the membrane fraction; YCR101C is not an essential gene	biological_process	molecular_function	integral to membrane|membrane
YDL100C	YDL100C	GET3	hom	Verified	0.277529788274379	0.390686668020762	no	1964	0.421235194877492	1367	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING|NUCLEOTIDE METABOLISM	ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Guanine nucleotide exchange factor for Gpa1p; amplifies G protein signaling; subunit of the GET complex, which is involved in Golgi to ER trafficking and insertion of proteins into the ER membrane; has low-level ATPase activity; protein abundance increases in response to DNA replication stress	retrograde vesicle-mediated transport, Golgi to ER|pheromone-dependent signal transduction involved in conjugation with cellular fusion|response to heat|protein insertion into ER membrane|response to metal ion|posttranslational protein targeting to membrane	ATPase activity|guanyl-nucleotide exchange factor activity	endoplasmic reticulum|GET complex
YDR518W	YDR518W	EUG1	hom	Verified	0.277239299867328	0.390798182455217	no	1965	0.384406109794023	1286	NA	FT		ENDOPLASMIC RETICULUM		Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER	protein folding	protein disulfide isomerase activity|protein disulfide oxidoreductase activity	endoplasmic reticulum
YBR217W	YBR217W	ATG12	hom	Verified	0.276046661801814	0.391256113555581	no	1966	0.38575533880933	1278	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS			Conserved ubiquitin-like modifier involved in autophagy and the Cvt pathway; conjugated to Atg5p to form a complex involved in Atg8p lipidation; Atg12p-Atg5p also forms a complex with Atg16p that is required for autophagosome formation	C-terminal protein lipidation|piecemeal microautophagy of nucleus|mitochondrion degradation|CVT pathway|autophagic vacuole assembly	Atg8 ligase activity|protein tag	Atg12-Atg5-Atg16 complex|pre-autophagosomal structure
YMR189W	YMR189W	GCV2	hom	Verified	0.275553793296745	0.391445401806272	no	1967	0.370261000911841	1238	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS	MITOCHONDRION		P subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of 5,10-methylene-THF in the cytoplasm	glycine decarboxylation via glycine cleavage system|one-carbon metabolic process	glycine dehydrogenase (decarboxylating) activity	mitochondrion|glycine cleavage complex
YLR308W	YLR308W	CDA2	hom	Verified	0.274285866021443	0.391932472721026	no	1968	0.390706925217699	1313	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM			Chitin deacetylase, together with Cda1p involved in the biosynthesis ascospore wall component, chitosan; required for proper rigidity of the ascospore wall	ascospore wall assembly	chitin deacetylase activity	chitosan layer of spore wall
YGR003W	YGR003W	CUL3	hom	Verified	0.273519720340931	0.392226867722851	no	1969	0.386859380553421	1246	NA	FT	PROTEOLYSIS	NUCLEUS	UBIQUITIN LIGASE COMPLEX	Ubiquitin-protein ligase, forms a complex with Elc1p that polyubiquitylates monoubiquitylated RNA polymerase II to trigger its proteolysis; cullin family member with similarity to Cdc53p and human CUL3	protein ubiquitination involved in ubiquitin-dependent protein catabolic process|ubiquitin-dependent protein catabolic process	ubiquitin-protein ligase activity	nucleus|Cul3-RING ubiquitin ligase complex|cytoplasm
YGR255C	YGR255C	COQ6	hom	Verified	0.271192986788055	0.393121303336978	no	1970	0.392913836729969	1308	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM	MITOCHONDRION		Putative flavin-dependent monooxygenase; involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; human COX6 can rescue a yeast cox6 mutant and is implicated in steroid-resistant nephrotic syndrome (SRNS)	ubiquinone biosynthetic process	N,N-dimethylaniline monooxygenase activity	mitochondrion|mitochondrial inner membrane
YKR009C	YKR009C	FOX2	hom	Verified	0.270944799314452	0.393216744187998	no	1971	0.36892661036122	1217	NA	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS			Multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway; has 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities	fatty acid beta-oxidation	enoyl-CoA hydratase activity|3-hydroxyacyl-CoA dehydrogenase activity	peroxisome
YER041W	YER041W	YEN1	hom	Verified	0.269687392416842	0.393700380339753	no	1972	0.391888153207377	1325	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		Holliday junction resolvase; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1 and has similarity to S. cerevisiae endonuclease Rth1p	DNA repair|response to DNA damage stimulus	single-stranded DNA specific endodeoxyribonuclease activity|crossover junction endodeoxyribonuclease activity	nucleus|cytoplasm
YFL056C	YFL056C	AAD6	hom	Verified	0.269382387383481	0.393817719108928	no	1973	0.38800672279569	1290	NA	FT	OXIDATION-REDUCTION PROCESS			Putative aryl-alcohol dehydrogenase; involved in oxidative stress response; similar to P. chrysosporium aryl-alcohol dehydrogenase; expression induced in cells treated with the mycotoxin patulin	cellular aldehyde metabolic process	aryl-alcohol dehydrogenase (NAD+) activity	cellular_component
YGR138C	YGR138C	TPO2	hom	Verified	0.268036966247418	0.394335432249897	no	1974	0.358614001442793	1200	NA	FT		PLASMA MEMBRANE		Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; specific for spermine; localizes to the plasma membrane; transcription of TPO2 is regulated by Haa1p; TPO2 has a paralog, TPO3, that arose from the whole genome duplication	spermine transport	spermine transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane|plasma membrane
YPL072W	YPL072W	UBP16	hom	Verified	0.267645808161565	0.394485983528301	no	1975	0.37166056478707	1230	NA	FT	PROTEOLYSIS	MITOCHONDRION		Deubiquitinating enzyme anchored to the outer mitochondrial membrane, probably not important for general mitochondrial functioning, but may perform a more specialized function at mitochondria	protein deubiquitination	ubiquitin-specific protease activity	mitochondrial outer membrane|cytoplasm
YNL134C	YNL134C	YNL134C	hom	Verified	0.266978296956581	0.394742935647125	no	1976	0.385812729623884	1254	NA	FT	OXIDATION-REDUCTION PROCESS	NUCLEUS		Protein of unknown function; similar to dehydrogenases from other model organisms; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress	biological_process	alcohol dehydrogenase (NADP+) activity	nucleus|cytoplasm
YDR511W	YDR511W	ACN9	hom	Verified	0.266916923406467	0.394766563114706	no	1977	0.356197823448185	1191	NA	FT	KETONE METABOLISM|CARBOHYDRATE METABOLISM	MITOCHONDRION		Protein of the mitochondrial intermembrane space, required for acetate utilization and gluconeogenesis; has orthologs in higher eukaryotes	carbon utilization|regulation of gluconeogenesis	molecular_function	mitochondrion|mitochondrial intermembrane space
YGL067W	YGL067W	NPY1	hom	Verified	0.266563244836114	0.39490272912878	no	1978	0.36342376342156	1182	NA	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM			NADH diphosphatase (pyrophosphatase), hydrolyzes the pyrophosphate linkage in NADH and related nucleotides; localizes to peroxisomes; nudix hydrolase family member	NADH metabolic process	NAD+ diphosphatase activity	peroxisome|cytoplasm
YER176W	YER176W	ECM32	hom	Verified	0.26654155491073	0.394911080153569	no	1979	0.376357662159604	1277	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION			DNA dependent ATPase/DNA helicase belonging to the Dna2p- and Nam7p-like family of helicases that is involved in modulating translation termination; interacts with the translation termination factors, localized to polysomes	regulation of translational termination	RNA helicase activity|DNA helicase activity	polysome
YKL202W_d	YKL202W	YKL202W	hom	Dubious	0.26610504694882	0.395079154097425	no	1980	0.367437474878694	1229	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YHR157W	YHR157W	REC104	hom	Verified	0.265711418311159	0.39523073443835	no	1981	0.383094022726438	1263	NA	FT	CELL CYCLE	NUCLEUS|CHROMOSOME		Protein involved in early stages of meiotic recombination; required for meiotic crossing over; forms a complex with Rec102p and Spo11p necessary during the initiation of recombination	meiotic DNA double-strand break formation|reciprocal meiotic recombination	molecular_function	condensed nuclear chromosome
YJL070C_p	YJL070C	YJL070C	hom	Uncharacterized	0.265421988626173	0.395342199479532	no	1982	0.355025114905648	1171	NA	FT	NUCLEOTIDE METABOLISM	MITOCHONDRION		Putative metallo-dependent hydrolase superfamily protein; similar to AMP deaminases but lacks key catalytic residues and does not rescue purine nucleotide metabolic defect of quadruple aah1 ade8 amd1 his1 mutant; may regulate purine nucleotide homeostasis as overexpression in an AMD1 strain grown in adenine results in greatly reduced GDP and GTP intracellular levels; not an essential gene; YJL070C has a paralog, YBR284W, that arose from the whole genome duplication	biological_process	AMP deaminase activity|molecular_function	mitochondrion|cytoplasm
YHL025W	YHL025W	SNF6	hom	Verified	0.2630327576086	0.39626266545453	no	1983	0.416158017300336	1377	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|CARBOHYDRATE METABOLISM	NUCLEUS	RSC COMPLEX	Subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; functions interdependently in transcriptional activation with Snf2p and Snf5p; relocates to the cytosol under hypoxic conditions	sucrose catabolic process|nucleotide-excision repair|chromatin remodeling|positive regulation of transcription from RNA polymerase II promoter	molecular_function	SWI/SNF complex|nucleus
YLR414C	YLR414C	PUN1	hom	Verified	0.262059061531175	0.396637954107885	no	1984	0.363885683403282	1181	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL WALL ORG/BIOGENESIS	PLASMA MEMBRANE		Plasma membrane protein with a role in cell wall integrity; co-localizes with Sur7p in punctate membrane patches; null mutant displays decreased thermotolerance; transcription induced upon cell wall damage and metal ion stress	fungal-type cell wall organization|protein oligomerization	molecular_function	integral to membrane|membrane raft|plasma membrane|cellular bud|cytoplasm
YLR326W_p	YLR326W	YLR326W	hom	Uncharacterized	0.26123306079743	0.396956392100847	no	1985	0.384271631184553	1238	NA					Putative protein of unknown function, predicted to be palmitoylated	biological_process	molecular_function	cellular_component
YJR043C	YJR043C	POL32	hom	Verified	0.261115537207516	0.397001705126705	no	1986	0.408782097380801	1332	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Third subunit of DNA polymerase delta, involved in chromosomal DNA replication; required for error-prone DNA synthesis in the presence of DNA damage and processivity; interacts with Hys2p, PCNA (Pol30p), and Pol1p	RNA-dependent DNA replication|lagging strand elongation|postreplication repair|base-excision repair|DNA replication, removal of RNA primer|nucleotide-excision repair|mismatch repair|double-strand break repair via break-induced replication|leading strand elongation	DNA-directed DNA polymerase activity|single-stranded DNA specific 3'-5' exodeoxyribonuclease activity	delta DNA polymerase complex|nucleus
YDR220C_d	YDR220C	YDR220C	hom	Dubious	0.260497022235853	0.397240205980963	no	1987	0.38767777573939	1296	NA					Dubious open reading frame, null mutant exhibits synthetic phenotype with alpha-synuclein	Unknown	Unknown	Unknown
YAL044W-A_p	YAL044W-A	YAL044W-A	hom	Uncharacterized	0.260128631924702	0.397382276433868	no	1988	0.367444445625716	1205	NA					Putative protein of unknown function; similar to S. pombe uvi31 which is a putative DNA repair protein	biological_process	molecular_function	cellular_component
YKL077W_p	YKL077W	YKL077W	hom	Uncharacterized	0.259344626371441	0.397684675025871	no	1989	0.401836555415449	1325	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole	biological_process	molecular_function	fungal-type vacuole
YHR176W	YHR176W	FMO1	hom	Verified	0.259072748836159	0.397789555212513	no	1990	0.400882266859787	1309	NA	FT	OXIDATION-REDUCTION PROCESS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Flavin-containing monooxygenase, localized to the cytoplasmic face of the ER membrane; catalyzes oxidation of biological thiols to maintain the ER redox buffer ratio for correct folding of disulfide-bonded proteins	protein folding	N,N-dimethylaniline monooxygenase activity	endoplasmic reticulum membrane
YKL157W	YKL157W	APE2	hom	Verified	0.258903273191964	0.397854936317045	no	1991	0.404927352764699	1333	NA	FT	PROTEOLYSIS	MITOCHONDRION		Aminopeptidase yscII; may have a role in obtaining leucine from dipeptide substrates; APE2 has a paralog, AAP1, that arose from the whole genome duplication	peptide catabolic process	metalloaminopeptidase activity	mitochondrion|extracellular region|cell wall-bounded periplasmic space
YEL066W	YEL066W	HPA3	hom	Verified	0.258889834641996	0.397860120826319	no	1992	0.35413224008921	1214	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		D-Amino acid N-acetyltransferase, catalyzes N-acetylation of D-amino acids through ordered bi-bi mechanism in which acetyl-CoA is first substrate bound and CoA is last product liberated; similar to Hpa2p, acetylates histones weakly in vitro	D-amino acid metabolic process	D-amino-acid N-acetyltransferase activity	nucleus|cytoplasm
YBL085W	YBL085W	BOI1	hom	Verified	0.257119720568025	0.398543177193076	no	1993	0.402137982251267	1314	NA	FT	SIGNALING|CELL DIVISION	SITE OF POLARIZED GROWTH		Protein implicated in polar growth; functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; relocalizes from bud neck to cytoplasm upon DNA replication stress; BOI1 has a paralog, BOI2, that arose from the whole genome duplication	cytokinesis, completion of separation|establishment of cell polarity|budding cell apical bud growth|Rho protein signal transduction	phospholipid binding	site of polarized growth|cellular bud|mating projection tip|cellular bud neck
YOR237W	YOR237W	HES1	hom	Verified	0.256989488641189	0.398593443743017	no	1994	0.427418896407358	1424	NA	FT	VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|MEMBRANE ORGANIZATION			Protein implicated in the regulation of ergosterol biosynthesis; one of a seven member gene family with a common essential function and non-essential unique functions; similar to human oxysterol binding protein (OSBP); HES1 has a paralog, KES1, that arose from the whole genome duplication	maintenance of cell polarity|endocytosis|exocytosis|sterol transport	lipid binding|oxysterol binding|sterol transporter activity	cellular_component
YJR003C_p	YJR003C	YJR003C	hom	Uncharacterized	0.256543500396933	0.39876559776215	no	1995	0.399863057337804	1325	NA	FT		MITOCHONDRION		Putative protein of unknown function; detected in highly purified mitochondria in high-throughput studies; predicted to be involved in ribosome biogenesis	biological_process	molecular_function	mitochondrion
YOL136C	YOL136C	PFK27	hom	Verified	0.256294340735404	0.398861783398372	no	1996	0.378070723711197	1252	NA	FT	CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY			6-phosphofructo-2-kinase, catalyzes synthesis of fructose-2,6-bisphosphate; inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate, expression induced by glucose and sucrose, transcriptional regulation involves protein kinase A	regulation of glycolysis|fructose 2,6-bisphosphate metabolic process	6-phosphofructo-2-kinase activity	cytoplasm
YMR082C_d	YMR082C	YMR082C	hom	Dubious	0.255893668615146	0.399016471807287	no	1997	0.412680789845836	1355	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YOL126C	YOL126C	MDH2	hom	Verified	0.255659059606591	0.39910705521202	no	1998	0.392596375049525	1278	NA	FT	PROTEIN LOCALIZATION|KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM|PEROXISOME ORGANIZATION			Cytoplasmic malate dehydrogenase, one of three isozymes that catalyze interconversion of malate and oxaloacetate; involved in the glyoxylate cycle and gluconeogenesis during growth on two-carbon compounds; interacts with Pck1p and Fbp1	protein import into peroxisome matrix|gluconeogenesis|malate metabolic process	L-malate dehydrogenase activity	cytosol|cytoplasm
YDR176W	YDR176W	NGG1	hom	Verified	0.255365395089216	0.399220447823276	no	1999	0.420439499999142	1386	NA	FF|FT	CHROMATIN ORGANIZATION	NUCLEUS	HISTONE ACETYLTRANSFERASE	Transcriptional regulator involved in glucose repression of Gal4p-regulated genes; component of transcriptional adaptor and histone acetyltransferase complexes, the ADA complex, the SAGA complex, and the SLIK complex	histone acetylation|chromatin modification	histone acetyltransferase activity|transcription cofactor activity	SLIK (SAGA-like) complex|Ada2/Gcn5/Ada3 transcription activator complex|SAGA complex
YOR357C	YOR357C	SNX3	hom	Verified	0.255195924676011	0.399285889264539	no	2000	0.398940991245429	1310	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Sorting nexin required to maintain late-Golgi resident enzymes in their proper location by recycling molecules from the prevacuolar compartment; contains a PX domain and sequence similarity to human Snx3p	protein localization|late endosome to Golgi transport	phosphatidylinositol-3-phosphate binding	cytosol|endosome
YBR219C_p	YBR219C	YBR219C	hom	Uncharacterized	0.254051209463315	0.399727998061075	no	2001	0.402087759653855	1309	NA					Putative protein of unknown function; YBR219C is not an essential gene	biological_process	molecular_function	integral to membrane
YGL049C	YGL049C	TIF4632	hom	Verified	0.253674945392207	0.399873345854227	no	2002	0.389043890517143	1302	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION		RIBOSOME	Translation initiation factor eIF4G, subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); associates with the poly(A)-binding protein Pab1p, also interacts with eIF4A (Tif1p); TIF4632 has a paralog, TIF4631, that arose from the whole genome duplication	translational initiation|stress granule assembly	translation initiation factor binding|mRNA binding|translation initiation factor activity	eukaryotic translation initiation factor 4F complex|cytoplasmic stress granule
YGR053C_p	YGR053C	YGR053C	hom	Uncharacterized	0.253422563719476	0.399970846645625	no	2003	0.399391207359522	1313	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YBR118W	YBR118W	TEF2	hom	Verified	0.253388740302647	0.399983913876321	no	2004	0.384212857890211	1271	NA	FT	TRANSLATION|NUCLEOTIDE METABOLISM|RNA LOCALIZATION	CYTOSKELETON	RIBOSOME	Translational elongation factor EF-1 alpha; also encoded by TEF1; functions in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomes; may also have a role in tRNA re-export from the nucleus; TEF2 has a paralog, TEF1, that arose from the whole genome duplication	translational elongation|tRNA export from nucleus	GDP binding|GTP binding|translation elongation factor activity	ribosome|eukaryotic translation elongation factor 1 complex|cytoplasm
YGR197C	YGR197C	SNG1	hom	Verified	0.253278934643068	0.400026336615586	no	2005	0.392669118912039	1288	NA	FT		PLASMA MEMBRANE		Protein involved in resistance to nitrosoguanidine (MNNG) and 6-azauracil (6-AU); expression is regulated by transcription factors involved in multidrug resistance	nucleobase-containing compound transport	molecular_function	integral to membrane|plasma membrane
YGL213C	YGL213C	SKI8	hom	Verified	0.252870704245639	0.400184064254746	no	2006	0.392940440090249	1297	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE	NUCLEUS|CHROMOSOME		Ski complex component and WD-repeat protein, mediates 3'-5' RNA degradation by the cytoplasmic exosome; also required for meiotic double-strand break recombination; null mutants have superkiller phenotype	nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'|nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay|protein complex assembly|nuclear-transcribed mRNA catabolic process, non-stop decay|protein-DNA complex assembly|reciprocal meiotic recombination	molecular_function	Ski complex|nuclear chromosome
YHR009C_p	YHR009C	TDA3	hom	Uncharacterized	0.252595592661457	0.400290368074424	no	2007	0.402230930875082	1328	NA	FT	VESICLE-MEDIATED TRANSPORT|OXIDATION-REDUCTION PROCESS			Putative oxidoreductase involved in late endosome to Golgi transport; physical and genetical interactions with Btn2p; null mutant is viable, has extended S phase, and sensitive to expression of top1-T722A allele; similar to human FOXRED1	retrograde transport, endosome to Golgi	molecular_function	late endosome|cytoplasm
YMR066W	YMR066W	SOV1	hom	Verified	0.252222067964187	0.400434710795427	no	2008	0.40858459606784	1364	NA	FT		MITOCHONDRION		Mitochondrial protein of unknown function	biological_process	molecular_function	mitochondrion
YDL012C	YDL012C	YDL012C	hom	Verified	0.252153266149244	0.400461299654108	no	2009	0.376798702664717	1252	NA	FT		PLASMA MEMBRANE		Tail-anchored plasma membrane protein with a conserved CYSTM module; possibly involved in response to stress; may contribute to non-homologous end-joining (NHEJ) based on ydl012c htz1 double null phenotype; YDL012C has a paralog, YBR016W, that arose from the whole genome duplication	biological_process	molecular_function	plasma membrane
YHR121W	YHR121W	LSM12	hom	Verified	0.251981042919766	0.400527858337902	no	2010	0.399390271691861	1327	NA	FT		NUCLEUS		Protein of unknown function that may function in RNA processing; interacts with Pbp1p and Pbp4p and associates with ribosomes; contains an RNA-binding LSM domain and an AD domain; GFP-fusion protein is induced by the DNA-damaging agent MMS; relative distribution to the nucleus increases upon DNA replication stress	RNA metabolic process	RNA binding	ribosome|nucleus|cytoplasmic stress granule|cytoplasm
YER027C	YER027C	GAL83	hom	Verified	0.250874136784662	0.40095571046544	no	2011	0.392368047173841	1274	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|SIGNALING|PROTEIN PHOSPHORYLATION	ENDOMEMBRANE SYSTEM|NUCLEUS		One of three possible beta-subunits of the Snf1 kinase complex, allows nuclear localization of the Snf1 kinase complex in the presence of a nonfermentable carbon source; contains glycogen-binding domain	signal transduction|cell adhesion|protein phosphorylation|invasive growth in response to glucose limitation|regulation of protein complex assembly	AMP-activated protein kinase activity	AMP-activated protein kinase complex|nucleus|nuclear envelope lumen|cytoplasm
YOR131C	YOR131C	YOR131C	hom	Verified	0.25083410464447	0.40097118630714	no	2012	0.40790583098422	1361	NA	FT		NUCLEUS		Putative haloacid dehalogenase-like hydrolase; non-essential gene; overexpression causes a cell cycle delay or arrest; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	nucleus|cytoplasm
YPR148C	YPR148C	YPR148C	hom	Verified	0.25079788321316	0.400985189118266	no	2013	0.383513332073074	1270	NA					Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern	biological_process	molecular_function	ribosome|cytoplasm
YJL048C	YJL048C	UBX6	hom	Verified	0.250665526318878	0.401036357934616	no	2014	0.395251251655705	1308	NA	FT	PROTEOLYSIS	NUCLEUS		UBX (ubiquitin regulatory X) domain-containing protein; interacts with Cdc48p, transcription is repressed when cells are grown in media containing inositol and choline; UBX6 has a paralog, UBX7, that arose from the whole genome duplication	sporulation resulting in formation of a cellular spore|ubiquitin-dependent protein catabolic process	molecular_function	nucleus
YNL146W_p	YNL146W	YNL146W	hom	Uncharacterized	0.250054807401143	0.401272482187686	no	2015	0.41151452776336	1368	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YNL146W is not an essential gene	biological_process	molecular_function	endoplasmic reticulum
YGL083W	YGL083W	SCY1	hom	Verified	0.249728086502937	0.401398818169337	no	2016	0.400417877127882	1311	NA	FT	PROTEIN PHOSPHORYLATION			Putative kinase, suppressor of GTPase mutant, similar to bovine rhodopsin kinase	biological_process	molecular_function	clathrin-coated vesicle
YCL057W	YCL057W	PRD1	hom	Verified	0.249026779398239	0.401670033418182	no	2017	0.384052043202012	1291	NA	FT	PROTEOLYSIS	MITOCHONDRION		Zinc metalloendopeptidase; found in the cytoplasm and intermembrane space of mitochondria; with Cym1p, involved in degradation of mitochondrial proteins and of presequence peptides cleaved from imported proteins; protein abundance increases in response to DNA replication stress	proteolysis	metalloendopeptidase activity	mitochondrion|cytoplasm|mitochondrial intermembrane space
YNR007C	YNR007C	ATG3	hom	Verified	0.248197724552659	0.401990713413213	no	2018	0.413840849123909	1372	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS			E2-like enzyme involved in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; plays a role in formation of Atg8p-phosphatidylethanolamine conjugates, which are involved in membrane dynamics during autophagy and Cvt; interaction with Atg8p is regulated by its acetylation by Esa1p (catalytic subunit of NuA4 histone acetyltransferase complex) while attenuation of Atg3 acetylation is mediated by histone deacetylase Rpd3p	C-terminal protein lipidation|piecemeal microautophagy of nucleus|mitochondrion degradation|CVT pathway|autophagic vacuole assembly	Atg8 ligase activity	cytosol|cytoplasm
YNL321W	YNL321W	VNX1	hom	Verified	0.248090386410322	0.402032236840897	no	2019	0.406890048781614	1313	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Calcium/H+ antiporter localized to the endoplasmic reticulum membrane; member of the calcium exchanger (CAX) family; potential Cdc28p substrate	potassium ion transport|sodium ion transport|hydrogen transport	potassium:hydrogen antiporter activity|sodium:hydrogen antiporter activity|calcium:hydrogen antiporter activity	fungal-type vacuole membrane|integral to membrane|endoplasmic reticulum membrane|fungal-type vacuole
YDR065W	YDR065W	RRG1	hom	Verified	0.245726360648211	0.402947032440417	no	2020	0.396683144452342	1304	NA	FT	ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS	MITOCHONDRION		Protein of unknown function, required for vacuolar acidification and mitochondrial genome maintenance; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	mitochondrial genome maintenance|vacuolar acidification	molecular_function	mitochondrion
YOL062C	YOL062C	APM4	hom	Verified	0.243424608453486	0.403838241122461	no	2021	0.396876907940549	1311	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|PLASMA MEMBRANE		Mu2-like subunit of the clathrin associated protein complex (AP-2); involved in vesicle transport	intracellular protein transport|vesicle-mediated transport	molecular_function	AP-2 adaptor complex
YOR274W	YOR274W	MOD5	hom	Verified	0.242558228940926	0.404173821690699	no	2022	0.40523814324029	1351	NA	FT	RNA PROCESSING	NUCLEUS|MITOCHONDRION		Delta 2-isopentenyl pyrophosphate:tRNA isopentenyl transferase; required for biosynthesis of the modified base isopentenyladenosine in mitochondrial and cytoplasmic tRNAs; gene is nuclear and encodes two isozymic forms; converts to a prion form, and prion conversion contributes to azole antifungal resistance by upregulating ergosterol biosynthesis	tRNA modification	tRNA dimethylallyltransferase activity	cytosol|mitochondrion|nucleolus|nucleus
YLL041C	YLL041C	SDH2	hom	Verified	0.241710025022241	0.404502430511191	no	2023	0.395118557910438	1274	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Iron-sulfur protein subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain	mitochondrial electron transport, succinate to ubiquinone|cellular respiration|tricarboxylic acid cycle	succinate dehydrogenase (ubiquinone) activity	mitochondrial respiratory chain complex II|mitochondrion|mitochondrial membrane
YER095W	YER095W	RAD51	hom	Verified	0.241453504656964	0.404601824202895	no	2024	0.420107852651422	1387	NA	FF|FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Strand exchange protein, forms a helical filament with DNA that searches for homology; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; homolog of Dmc1p and bacterial RecA protein	strand invasion|telomere maintenance via recombination|heteroduplex formation|meiotic joint molecule formation|reciprocal meiotic recombination|double-strand break repair via single-strand annealing	recombinase activity|single-stranded DNA binding|DNA-dependent ATPase activity	condensed nuclear chromosome|nuclear chromosome
YLR049C_p	YLR049C	YLR049C	hom	Uncharacterized	0.23941037170628	0.405393694184242	no	2025	0.348327104774825	1183	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YFL044C	YFL044C	OTU1	hom	Verified	0.238781796446778	0.40563739315764	no	2026	0.392831052226584	1298	NA	FT	PROTEOLYSIS	NUCLEUS		Deubiquitylation enzyme that binds to the chaperone-ATPase Cdc48p; may contribute to regulation of protein degradation by deubiquitylating substrates that have been ubiquitylated by Ufd2p; member of the Ovarian Tumor (OTU) family; protein abundance increases in response to DNA replication stress	protein deubiquitination|regulation of transcription, DNA-dependent	ubiquitin-specific protease activity	nucleus|cytoplasm
YLR287C-A	YLR287C-A	RPS30A	hom	Verified	0.238587359684685	0.405712783809069	no	2027	0.391161648426568	1295	NA	FT	TRANSLATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S30, no bacterial homolog; RPS30A has a paralog, RPS30B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic small ribosomal subunit|cytoplasmic stress granule
YOR109W	YOR109W	INP53	hom	Verified	0.23835472524734	0.405802989771632	no	2028	0.400525933804439	1309	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|MEMBRANE ORGANIZATION	CYTOSKELETON		Polyphosphatidylinositol phosphatase, dephosphorylates multiple phosphatidylinositols; involved in trans Golgi network-to-early endosome pathway; hyperosmotic stress causes translocation to actin patches; contains Sac1 and 5-ptase domains	phosphatidylinositol dephosphorylation	phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|phosphatidylinositol-3-phosphatase activity|phosphatidylinositol-4-phosphate phosphatase activity	membrane|actin cortical patch|cytoplasm
YCR099C_p	YCR099C	YCR099C	hom	Uncharacterized	0.237952743420014	0.405958873397649	no	2029	0.449444140981003	1495	NA					Putative protein of unknown function	biological_process	molecular_function	integral to membrane
YKL188C	YKL188C	PXA2	hom	Verified	0.237702599237049	0.406055883774167	no	2030	0.398942506232067	1301	NA	FT	NUCLEOTIDE METABOLISM			Subunit of a heterodimeric peroxisomal ATP-binding cassette transporter complex (Pxa1p-Pxa2p), required for import of long-chain fatty acids into peroxisomes; similarity to human adrenoleukodystrophy transporter ABCD1 and ABCD2 and ALD-related proteins; mutations in ABCD1 cause X-linked adrenoleukodystrophy (X-ALD), a peroxisomal disorder	fatty acid transport	ATPase activity, coupled to transmembrane movement of substances	integral to membrane|integral to peroxisomal membrane
YOL028C	YOL028C	YAP7	hom	Verified	0.237538525025329	0.406119517813443	no	2031	0.410857755219025	1355	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Putative basic leucine zipper (bZIP) transcription factor; YAP7 has a paralog, YAP5, that arose from the whole genome duplication	positive regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding	nucleus
YPR006C	YPR006C	ICL2	hom	Verified	0.237040277409982	0.406312771835525	no	2032	0.409849758783907	1354	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		2-methylisocitrate lyase of the mitochondrial matrix, functions in the methylcitrate cycle to catalyze the conversion of 2-methylisocitrate to succinate and pyruvate; ICL2 transcription is repressed by glucose and induced by ethanol	threonine catabolic process|propionate metabolic process	methylisocitrate lyase activity	mitochondrion|mitochondrial matrix
YOR055W_d	YOR055W	YOR055W	hom	Dubious	0.235943411292162	0.406738290849052	no	2033	0.401352662126132	1340	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YOR269W	YOR269W	PAC1	hom	Verified	0.235844854589371	0.406776530405572	no	2034	0.394441149721763	1272	NA	FT	CELL CYCLE|CELL DIVISION	NUCLEUS|CYTOSKELETON		Involved in nuclear migration, part of the dynein/dynactin pathway; targets dynein to microtubule tips, which is necessary for sliding of microtubules along bud cortex; serves at interface between dynein's ATPase site and its microtubule binding stalk, causing individual dynein motors to remain attached to microtubules for long periods; synthetic lethal with bni1; homolog of human LIS1, mutations in which cause the severe brain disorder lissencephaly	nuclear migration along microtubule	microtubule plus-end binding	cytoplasmic microtubule|nucleus|cytoplasm
YJL059W	YJL059W	YHC3	hom	Verified	0.234762500988112	0.407196537129161	no	2035	0.402982305827748	1345	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|VACUOLAR TRANSPORT			Vacuolar membrane protein involved in the ATP-dependent transport of arginine into the vacuole and possibly in balancing ion homeostasis; homolog of human CLN3 involved in Batten disease (juvenile onset neuronal ceroid lipofuscinosis)	basic amino acid transport|regulation of intracellular pH|arginine transport	molecular_function	integral to membrane|fungal-type vacuole
YNR052C	YNR052C	POP2	hom	Verified	0.233662765702673	0.407623398123732	no	2036	0.462503987926425	1534	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|RNA PROCESSING	NUCLEUS|SITE OF POLARIZED GROWTH		RNase of the DEDD superfamily, subunit of the Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation	regulation of transcription from RNA polymerase II promoter|positive regulation of transcription elongation from RNA polymerase II promoter|nuclear-transcribed mRNA poly(A) tail shortening|transcription elongation from RNA polymerase II promoter	3'-5'-exoribonuclease activity	CCR4-NOT core complex|mating projection tip|cytoplasmic mRNA processing body|cytoplasm
YOR142W	YOR142W	LSC1	hom	Verified	0.23344254857117	0.407708888350624	no	2037	0.391682024898067	1281	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Alpha subunit of succinyl-CoA ligase, which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate; phosphorylated	tricarboxylic acid cycle|succinyl-CoA metabolic process	succinate-CoA ligase (ADP-forming) activity	mitochondrial nucleoid|mitochondrion
YNL265C	YNL265C	IST1	hom	Verified	0.233134877832666	0.407828336195498	no	2038	0.418423157671736	1378	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT			Protein with a positive role in the multivesicular body sorting pathway; functions and forms a complex with Did2p; recruitment to endosomes is mediated by the Vps2p-Vps24p subcomplex of ESCRT-III; also interacts with Vps4p	late endosome to vacuole transport via multivesicular body sorting pathway	molecular_function	endosome|cytoplasm
YDL062W_d	YDL062W	YDL062W	hom	Dubious	0.231962779369163	0.408283461562851	no	2039	0.414258965140934	1388	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized ORF YDL063C; YDL062W is not essential	Unknown	Unknown	Unknown
YCL040W	YCL040W	GLK1	hom	Verified	0.230609409081299	0.408809128617162	no	2040	0.415212935319725	1341	NA	FT	CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY			Glucokinase; catalyzes the phosphorylation of glucose at C6 in the first irreversible step of glucose metabolism; one of three glucose phosphorylating enzymes; expression regulated by non-fermentable carbon sources; GLK1 has a paralog, EMI2, that arose from the whole genome duplication	glucose import|mannose metabolic process|glycolysis|glucose metabolic process	glucokinase activity	cytosol|plasma membrane
YBR084W	YBR084W	MIS1	hom	Verified	0.229762426516333	0.409138191468525	no	2041	0.398947291491349	1323	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM	MITOCHONDRION		Mitochondrial C1-tetrahydrofolate synthase, involved in interconversion between different oxidation states of tetrahydrofolate (THF); provides activities of formyl-THF synthetase, methenyl-THF cyclohydrolase, and methylene-THF dehydrogenase	nucleobase-containing compound metabolic process|folic acid biosynthetic process	formate-tetrahydrofolate ligase activity|methylenetetrahydrofolate dehydrogenase (NADP+) activity|methenyltetrahydrofolate cyclohydrolase activity	mitochondrion
YDR253C	YDR253C	MET32	hom	Verified	0.228829319199022	0.409500788949767	no	2042	0.4289443655159	1430	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|CELL CYCLE|AMINO ACID METABOLISM	NUCLEUS		Zinc-finger DNA-binding transcription factor; involved in transcriptional regulation of the methionine biosynthetic genes; MET32 has a paralog, MET31, that arose from the whole genome duplication	regulation of mitotic cell cycle|regulation of sulfur amino acid metabolic process|regulation of transcription from RNA polymerase II promoter	core promoter proximal region sequence-specific DNA binding|RNA polymerase II activating transcription factor binding|sequence-specific DNA binding|sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity	nucleus|cytoplasm
YCR045C	YCR045C	RRT12	hom	Verified	0.227846124835237	0.409882933597792	no	2043	0.415457905101664	1402	NA	FT	CELL WALL ORG/BIOGENESIS|PROTEOLYSIS	ENDOMEMBRANE SYSTEM|NUCLEUS		Probable subtilisin-family protease with a role in formation of the dityrosine layer of spore walls; localizes to the spore wall and also the nuclear envelope and ER region in mature spores	ascospore wall assembly	serine-type peptidase activity	nuclear envelope|ascospore wall
YMR250W	YMR250W	GAD1	hom	Verified	0.226620166718287	0.410359554733099	no	2044	0.415524162168904	1389	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|RESPONSE TO OXIDATIVE STRESS			Glutamate decarboxylase, converts glutamate into gamma-aminobutyric acid (GABA) during glutamate catabolism; involved in response to oxidative stress	cellular response to oxidative stress|glutamate catabolic process	calmodulin binding|glutamate decarboxylase activity	cytoplasm
YGL086W	YGL086W	MAD1	hom	Verified	0.226516353267956	0.410399920836974	no	2045	0.405937108520992	1329	NA	FT	CELL CYCLE|CELL DIVISION	ENDOMEMBRANE SYSTEM|NUCLEUS|CHROMOSOME	NUCLEAR PORE|KINETOCHORE	Coiled-coil protein involved in the spindle-assembly checkpoint; required for inhibition of karyopherin/importin Pse1p (aka Kap121p) upon spindle assembly checkpoint arrest; phosphorylated by Mps1p upon checkpoint activation which leads to inhibition of the activity of the anaphase promoting complex; forms a complex with Mad2p	nucleocytoplasmic transport|mitotic cell cycle spindle assembly checkpoint|mitotic cell cycle G2/M transition decatenation checkpoint	molecular_function	nucleus|nuclear pore|kinetochore
YER096W	YER096W	SHC1	hom	Verified	0.226203613647291	0.410521530083037	no	2046	0.41884226584733	1367	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM			Sporulation-specific activator of Chs3p (chitin synthase III); required for the synthesis of the chitosan layer of ascospores; transcriptionally induced at alkaline pH; SHC1 has a paralog, SKT5, that arose from the whole genome duplication	ascospore formation|chitin biosynthetic process	enzyme activator activity	prospore membrane
YLR020C	YLR020C	YEH2	hom	Verified	0.225688176457927	0.410721977335966	no	2047	0.412906496738313	1379	NA	FT	LIPID METABOLISM|CELL WALL ORG/BIOGENESIS	PLASMA MEMBRANE		Steryl ester hydrolase, catalyzes steryl ester hydrolysis at the plasma membrane; involved in sterol metabolism	cell wall mannoprotein biosynthetic process|sterol metabolic process	sterol esterase activity	integral to membrane|plasma membrane
YJR005W	YJR005W	APL1	hom	Verified	0.225011842316494	0.410985030822228	no	2048	0.400506949674597	1342	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|PLASMA MEMBRANE		Beta-adaptin, large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport; similar to mammalian beta-chain of the clathrin associated protein complex	vesicle-mediated transport	molecular_function	AP-2 adaptor complex
YJL045W	YJL045W	YJL045W	hom	Verified	0.22476654585994	0.411080446356231	no	2049	0.398547892507187	1328	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Minor succinate dehydrogenase isozyme; homologous to Sdh1p, the major isozyme reponsible for the oxidation of succinate and transfer of electrons to ubiquinone; induced during the diauxic shift in a Cat8p-dependent manner	cellular respiration	succinate dehydrogenase (ubiquinone) activity	mitochondrion
YOR312C	YOR312C	RPL20B	hom	Verified	0.224618975042011	0.411137851059	no	2050	0.3639064777279	1210	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L20B; homologous to mammalian ribosomal protein L18A, no bacterial homolog; RPL20B has a paralog, RPL20A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YJR128W_d	YJR128W	YJR128W	hom	Dubious	0.224574462246915	0.411155166805707	no	2051	0.404518315661772	1351	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RSF2	Unknown	Unknown	Unknown
YDR509W_d	YDR509W	YDR509W	hom	Dubious	0.223877848851196	0.411426176163549	no	2052	0.39550982934516	1335	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YNL168C_p	YNL168C	FMP41	hom	Uncharacterized	0.223091171872504	0.411732274526204	no	2053	0.405406770250569	1364	NA	FT		MITOCHONDRION		Putative protein of unknown function; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YMR181C_p	YMR181C	YMR181C	hom	Uncharacterized	0.222700921203903	0.411884142174956	no	2054	0.409444579531635	1358	NA					Protein of unknown function; mRNA transcribed as part of a bicistronic transcript with a predicted transcriptional repressor RGM1/YMR182C; mRNA is destroyed by nonsense-mediated decay (NMD); not an essential gene; YMR181C has a paralog, YPL229W, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YMR044W	YMR044W	IOC4	hom	Verified	0.222636940970377	0.411909041605281	no	2055	0.422096082030044	1401	NA	FT	CHROMATIN ORGANIZATION	NUCLEUS		Member of a complex (Isw1b) with Isw1p and Ioc2p; interacts directly with H3K36me3 nucleosomes through its PWWP domain to recruit the Isw1b complex to open reading frames in a Set2p-dependent manner; Isw1b exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing	chromatin remodeling	nucleosome binding|ATPase activity|DNA binding	ISW1 complex
YCL044C	YCL044C	MGR1	hom	Verified	0.222572384864055	0.411934165509689	no	2056	0.406621667740174	1340	NA	FT	PROTEOLYSIS	MITOCHONDRION		Subunit of the mitochondrial (mt) i-AAA protease supercomplex, which degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr3p that binds to substrates to facilitate proteolysis; required for growth of cells lacking mtDNA	misfolded or incompletely synthesized protein catabolic process	misfolded protein binding	mitochondrion|i-AAA complex
YJL141C	YJL141C	YAK1	hom	Verified	0.222007767055888	0.41215391848407	no	2057	0.409844099919498	1361	NA	FT	PROTEIN PHOSPHORYLATION	NUCLEUS		Serine-threonine protein kinase; component of a glucose-sensing system that inhibits growth in response to glucose availability; upon nutrient deprivation Yak1p phosphorylates Pop2p to regulate mRNA deadenylation, the co-repressor Crf1p to inhibit transcription of ribosomal genes, and the stress-responsive transcription factors Hsf1p and Msn2p; nuclear localization negatively regulated by the Ras/PKA signaling pathway in the presence of glucose	protein phosphorylation	protein serine/threonine kinase activity|protein tyrosine kinase activity|protein kinase activity	nucleus|cytoplasm
YMR077C	YMR077C	VPS20	hom	Verified	0.221349189535743	0.412410275998845	no	2058	0.431265252829653	1418	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|PROTEOLYSIS|VACUOLAR TRANSPORT			Myristoylated subunit of ESCRTIII, the endosomal sorting complex required for transport of transmembrane proteins into the multivesicular body pathway to the lysosomal/vacuolar lumen; cytoplasmic protein recruited to endosomal membranes	intralumenal vesicle formation|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|late endosome to vacuole transport	protein binding	ESCRT III complex|cytoplasm
YKR032W_d	YKR032W	YKR032W	hom	Dubious	0.22026402660431	0.41283276738676	no	2059	0.406032557017461	1360	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YMR302C	YMR302C	YME2	hom	Verified	0.219433201195292	0.413156304686616	no	2060	0.383388148007624	1254	NA	FT	RNA PROCESSING|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Integral inner mitochondrial membrane protein with a role in maintaining mitochondrial nucleoid structure and number; mutants exhibit an increased rate of mitochondrial DNA escape; shows some sequence similarity to exonucleases	mitochondrial genome maintenance	molecular_function	mitochondrion|integral to mitochondrial inner membrane
YEL018W	YEL018W	EAF5	hom	Verified	0.219127162317553	0.413275496218318	no	2061	0.425080871184785	1438	NA	FT	CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE	NUCLEUS	HISTONE ACETYLTRANSFERASE	Esa1p-associated factor, non-essential subunit of the NuA4 acetyltransferase complex	DNA repair	molecular_function	nucleus|NuA4 histone acetyltransferase complex
YGL176C_p	YGL176C	YGL176C	hom	Uncharacterized	0.21831178877423	0.413593094932091	no	2062	0.421716526693898	1368	NA					Putative protein of unknown function; deletion mutant is viable and has no detectable phenotype	biological_process	molecular_function	cellular_component
YHR120W	YHR120W	MSH1	hom	Verified	0.218301689677747	0.413597029017827	no	2063	0.386232014543192	1295	NA	FT	RESPONSE TO DNA DAMAGE|MITOCHONDRION ORGANIZATION	MITOCHONDRION		DNA-binding protein of the mitochondria involved in repair of mitochondrial DNA, has ATPase activity and binds to DNA mismatches; has homology to E. coli MutS; transcription is induced during meiosis	DNA repair|mismatch repair|mitochondrial DNA repair|mitochondrion organization|reciprocal meiotic recombination|mitochondrial genome maintenance	guanine/thymine mispair binding|dinucleotide insertion or deletion binding|DNA-dependent ATPase activity	mitochondrion
YOR156C	YOR156C	NFI1	hom	Verified	0.217994752404211	0.413716600042777	no	2064	0.413545097927557	1372	NA	FT	CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME	RSC COMPLEX	SUMO E3 ligase, catalyzes the covalent attachment of SUMO (Smt3p) to proteins; primary E3 ligase for Sir4p; sumoylates Yku70p/Yku80p and Sir4p in vivo to promote chromatin anchoring; promotes telomere anchoring to the nuclear envelope; involved in maintenance of proper telomere length	protein sumoylation|chromosome segregation|chromosome condensation	SUMO ligase activity	nuclear chromatin|nucleus|cytoplasm
YGL138C_p	YGL138C	YGL138C	hom	Uncharacterized	0.217414821074037	0.413942540944131	no	2065	0.42184582367421	1403	NA					Putative protein of unknown function; has no significant sequence similarity to any known protein	biological_process	molecular_function	cellular_component
YOR007C	YOR007C	SGT2	hom	Verified	0.216045121734717	0.414476287966823	no	2066	0.408716967291311	1370	NA	FT	PROTEIN LOCALIZATION			Glutamine-rich cytoplasmic cochaperone; serves as a scaffold bringing together Get4, Get5p, and other TRC complex members that are required to mediate posttranslational insertion of tail-anchored proteins into the ER membrane; interacts with the prion domain of Sup35p; amyloid sensor; plays a role in targeting chaperones to prion aggregates; has similarity to human cochaperone SGT; forms cytoplasmic foci upon DNA replication stress	response to heat|posttranslational protein targeting to membrane	molecular_function	TRC complex|cytoplasm
YDR357C_p	YDR357C	CNL1	hom	Uncharacterized	0.215894918717692	0.414534828990442	no	2067	0.413206299457722	1359	NA					Protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; null mutant is sensitive to drug inducing secretion of vacuolar cargo; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	biological_process	molecular_function	BLOC-1 complex|cytoplasm
YJL152W_d	YJL152W	YJL152W	hom	Dubious	0.215439900978705	0.414712181910798	no	2068	0.364079103752571	1188	NA					Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YMR233W	YMR233W	TRI1	hom	Verified	0.215300345176328	0.414766580262803	no	2069	0.424443835036861	1396	NA	FT		NUCLEUS		Non-essential sumoylated protein of unknown function; similar to components of human SWI/SNF complex including SMRD3; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm, nucleus and nucleolus; TRI1 has a paralog, UAF30, that arose from the whole genome duplication	biological_process	molecular_function	nucleolus|nucleus|cytoplasm
YBL055C	YBL055C	YBL055C	hom	Verified	0.215292994765212	0.414769445472055	no	2070	0.406405396065582	1322	NA	FT	RESPONSE TO OXIDATIVE STRESS			3'-->5' exonuclease and endonuclease with a possible role in apoptosis; has similarity to mammalian and C. elegans apoptotic nucleases	cellular response to oxidative stress|apoptotic DNA fragmentation	3'-5'-exodeoxyribonuclease activity|endonuclease activity	cytoplasm
YER057C	YER057C	HMF1	hom	Verified	0.214629963290595	0.415027915487465	no	2071	0.401661984387182	1315	NA	FT		NUCLEUS		Member of the p14.5 protein family with similarity to Mmf1p, functionally complements Mmf1p function when targeted to mitochondria; heat shock inducible; high-dosage growth inhibitor; forms a homotrimer in vitro	biological_process	molecular_function	cytosol|nucleus|cytoplasm
YGR080W	YGR080W	TWF1	hom	Verified	0.213592957218512	0.415432245993995	no	2072	0.412171761783768	1382	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Twinfilin, highly conserved actin monomer-sequestering protein involved in regulation of the cortical actin cytoskeleton, composed of two cofilin-like regions, localizes actin monomers to sites of rapid filament assembly	bipolar cellular bud site selection|actin polymerization or depolymerization|sequestering of actin monomers	actin monomer binding	mating projection tip|actin cortical patch
YDR169C	YDR169C	STB3	hom	Verified	0.212053732763787	0.41603255735294	no	2073	0.410126575314275	1340	NA	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Ribosomal RNA processing element (RRPE)-binding protein; involved in the glucose-induced transition from quiescence to growth; restricted to nucleus in quiescent cells, released into cytoplasm after glucose repletion; binds Sin3p; relative distribution to the nucleus increases upon DNA replication stress	positive regulation of transcription from RNA polymerase II promoter by glucose	sequence-specific DNA binding	nucleus|cytoplasm
YOL106W_d	YOL106W	YOL106W	hom	Dubious	0.212011526129432	0.41604902108607	no	2074	0.414148253407228	1345	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YLR011W	YLR011W	LOT6	hom	Verified	0.211011307981078	0.416439223763849	no	2075	0.390740707875759	1299	NA	FT	PROTEIN LOCALIZATION|OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		FMN-dependent NAD(P)H:quinone reductase, may be involved in quinone detoxification; expression elevated at low temperature; sequesters the Cin5p transcription factor in the cytoplasm in complex with the proteasome under reducing conditions	cellular response to oxidative stress|cytoplasmic sequestering of transcription factor	NAD(P)H dehydrogenase (quinone) activity|transcription factor binding	cytosol|nucleus|cytoplasm
YHR138C	YHR138C	YHR138C	hom	Verified	0.210435212003078	0.416664006334589	no	2076	0.421976114022976	1372	NA	FT	MEMBRANE ORGANIZATION			Protein of unknown function; similar to Pbi2p; double null mutant lacking Pbi2p and Yhr138cp exhibits highly fragmented vacuoles; protein abundance increases in response to DNA replication stress	vacuole fusion, non-autophagic	endopeptidase inhibitor activity	cellular_component
YCR001W_d	YCR001W	YCR001W	hom	Dubious	0.209150529067251	0.417165365179061	no	2077	0.395137082873393	1318	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR001W is not an essential gene	Unknown	Unknown	Unknown
YNR002C	YNR002C	ATO2	hom	Verified	0.20909096368661	0.417188614368462	no	2078	0.396265227528999	1307	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION|PLASMA MEMBRANE		Putative transmembrane protein involved in export of ammonia; ammonia is a starvation signal that promotes cell death in aging colonies; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family; homolog of Y. lipolytica Gpr1p; ATO2 has a paralog, ADY2, that arose from the whole genome duplication	ammonium transport|nitrogen utilization	ammonium transmembrane transporter activity	mitochondrion|integral to membrane|plasma membrane
YPR068C	YPR068C	HOS1	hom	Verified	0.209021690391353	0.417215653054988	no	2079	0.404756743702418	1302	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION	NUCLEUS		Class I histone deacetylase (HDAC) family member that deacetylates Smc3p on lysine residues at anaphase onset; has sequence similarity to Hda1p, Rpd3p, Hos2p, and Hos3p; interacts with the Tup1p-Ssn6p corepressor complex	peptidyl-lysine deacetylation|histone H4 deacetylation|positive regulation of transcription from RNA polymerase II promoter	histone deacetylase activity|protein deacetylase activity	histone deacetylase complex
YEL007W	YEL007W	MIT1	hom	Verified	0.208602329047045	0.417379346129462	no	2080	0.401953478794498	1324	NA	FT		NUCLEUS		Transcriptional regulator of pseudohyphal growth; protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1) and C. albicans Wor1	biological_process	molecular_function	nucleus|cytoplasm
YMR272C	YMR272C	SCS7	hom	Verified	0.206279097189305	0.418286452721052	no	2081	0.435910501690054	1453	NA	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Sphingolipid alpha-hydroxylase, functions in the alpha-hydroxylation of sphingolipid-associated very long chain fatty acids, has both cytochrome b5-like and hydroxylase/desaturase domains, not essential for growth	inositolphosphoceramide metabolic process	fatty acid alpha-hydroxylase activity	integral to membrane|endoplasmic reticulum|membrane
YKR018C	YKR018C	YKR018C	hom	Verified	0.206155992024602	0.418334531342415	no	2082	0.419721362732935	1389	NA	FT		NUCLEUS|MITOCHONDRION		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress; YKR018C has a paralog, IML2, that arose from the whole genome duplication	biological_process	molecular_function	nucleus|cytoplasm
YDR443C	YDR443C	SSN2	hom	Verified	0.205955402813009	0.418412873908494	no	2083	0.400981662242605	1299	NA	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for stable association of Srb10p-Srb11p kinase; essential for transcriptional regulation	negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter by galactose	RNA polymerase II transcription coactivator activity|RNA polymerase II transcription factor recruiting transcription factor activity	mediator complex
YKR078W	YKR078W	YKR078W	hom	Verified	0.20537946512095	0.418637831384361	no	2084	0.425869942221858	1393	NA					Cytoplasmic protein of unknown function, has similarity to Vps5p; potential Cdc28p substrate; contains a Phox homology (PX) domain and specifically binds phosphatidylinositol 3-phosphate (PtdIns-3-P)	biological_process	phosphatidylinositol-3-phosphate binding	cytoplasm
YLR104W_p	YLR104W	LCL2	hom	Uncharacterized	0.205265052712541	0.41868252328938	no	2085	0.42395463795725	1376	NA	FT	PROTEOLYSIS			Putative protein of unknown function; mutant is deficient in amounts of cell wall mannosylphosphate and has long chronological lifespan; genetic interactions suggest a role in ER-associated protein degradation (ERAD)	ER-associated protein catabolic process	molecular_function	cellular_component
YER119C	YER119C	AVT6	hom	Verified	0.203350575856619	0.419430513702323	no	2086	0.418992954757659	1399	NA	FT	VACUOLAR TRANSPORT			Vacuolar aspartate and glutamate exporter; member of a family of seven genes (AVT1-7) related to vesicular GABA-glycine transporters; involved in compartmentalizing acidic amino acids in response to nitrogen starvation; AVT6 has a paralog, AVT5, that arose from the whole genome duplication	amino acid export from vacuole|transmembrane transport	L-aspartate transmembrane transporter activity|transporter activity|L-glutamate transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane|fungal-type vacuole
YER010C	YER010C	YER010C	hom	Verified	0.202344391591598	0.419823749086866	no	2087	0.41675632838543	1377	NA					Protein of unknown function, forms a ring-shaped homotrimer; has similarity to members of the prokaryotic rraA family; possibly involved in a phosphotransfer reaction	biological_process	molecular_function	cellular_component
YJR102C	YJR102C	VPS25	hom	Verified	0.201160424027082	0.420286567978124	no	2088	0.438005930663818	1442	NA	FF|FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|PROTEOLYSIS|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS			Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome	negative regulation of transcription from RNA polymerase II promoter by glucose|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|protein targeting to vacuole	structural molecule activity	ESCRT II complex
YDL175C	YDL175C	AIR2	hom	Verified	0.200018835505167	0.420732925088088	no	2089	0.424631701780179	1424	NA	FT	RNA PROCESSING	NUCLEUS		RNA-binding subunit of the TRAMP nuclear RNA surveillance complex; involved in nuclear RNA processing and degradation; involved in TRAMP complex assembly as a bridge between Mtr4p and Trf4p; stimulates the poly(A) polymerase activity of Pap2p in vitro; has 5 zinc knuckle motifs; AIR2 has a paralog, AIR1, that arose from the whole genome duplication	nuclear polyadenylation-dependent CUT catabolic process|nuclear mRNA surveillance of mRNA 3'-end processing|nuclear polyadenylation-dependent tRNA catabolic process|nuclear polyadenylation-dependent snoRNA catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|nuclear polyadenylation-dependent snRNA catabolic process|ncRNA polyadenylation|tRNA modification	polynucleotide adenylyltransferase activity|RNA binding|protein binding, bridging	nucleolus|TRAMP complex
YJL024C	YJL024C	APS3	hom	Verified	0.199477329851486	0.420944687577562	no	2090	0.429966618394213	1427	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Small subunit of the clathrin-associated adaptor complex AP-3; involved in vacuolar protein sorting; related to the sigma subunit of the mammalian clathrin AP-3 complex; suppressor of loss of casein kinase 1 function; protein abundance increases in response to DNA replication stress	Golgi to vacuole transport|vesicle-mediated transport	molecular_function	AP-3 adaptor complex
YGR165W	YGR165W	MRPS35	hom	Verified	0.19939948853886	0.420975130268422	no	2091	0.437980881214124	1435	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the small subunit; null mutant does not grow on glycerol, is sensitive to 2,4-dichlorophenol, and accumulates large lipid droplets	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YKL090W	YKL090W	CUE2	hom	Verified	0.197943480663289	0.421544642260768	no	2092	0.414423501940477	1368	NA					Protein of unknown function; has two CUE domains that bind ubiquitin, which may facilitate intramolecular monoubiquitination	biological_process	ubiquitin binding	cellular_component
YHR021C	YHR021C	RPS27B	hom	Verified	0.197874619635679	0.421571581066828	no	2093	0.428229692344403	1398	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S27, no bacterial homolog; RPS27B has a paralog, RPS27A, that arose from the whole genome duplication	cytoplasmic translation|ribosomal small subunit assembly|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome	cytosolic small ribosomal subunit
YHR029C	YHR029C	YHI9	hom	Verified	0.196846543437287	0.421973813611666	no	2094	0.427505403498525	1390	NA	FT	SIGNALING			Protein of unknown function; null mutant is defective in unfolded protein response; possibly involved in a membrane regulation metabolic pathway; member of the PhzF superfamily, though most likely not involved in phenazine production	endoplasmic reticulum unfolded protein response	molecular_function	cellular_component
YAL026C	YAL026C	DRS2	hom	Verified	0.196606447298406	0.422067762437622	no	2095	0.419604374007113	1390	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|RIBOSOME BIOGENESIS|ION HOMEOSTASIS|ION HOMEOSTASIS	GOLGI APPARATUS		Aminophospholipid translocase (flippase) that maintains membrane lipid asymmetry in post-Golgi secretory vesicles; contributes to clathrin-coated vesicle formation and endocytosis; mutations in human homolog ATP8B1 result in liver disease	intracellular protein transport|post-Golgi vesicle-mediated transport|phospholipid translocation|endocytosis|ribosomal small subunit assembly	phospholipid-translocating ATPase activity	trans-Golgi network|integral to membrane
YCL048W	YCL048W	SPS22	hom	Verified	0.196468213471719	0.422121854889393	no	2096	0.422902582240387	1385	NA	FT	CELL WALL ORG/BIOGENESIS	PLASMA MEMBRANE		Protein of unknown function; SPS22 has a paralog, SPS2, that arose from the whole genome duplication; redundant with Sps2p for the organization of the beta-glucan layer of the spore wall	ascospore wall assembly|fungal-type cell wall organization	molecular_function	plasma membrane
YKL046C	YKL046C	DCW1	hom	Verified	0.196175050098002	0.422236577876517	no	2097	0.392894670039446	1310	NA	FT	CELL WALL ORG/BIOGENESIS|CELL DIVISION|CARBOHYDRATE METABOLISM	PLASMA MEMBRANE		Putative mannosidase, GPI-anchored membrane protein required for cell wall biosynthesis in bud formation;homologous to Dfg5p	fungal-type cell wall biogenesis|budding cell bud growth	mannosidase activity	anchored to plasma membrane
YGL179C	YGL179C	TOS3	hom	Verified	0.195636163091702	0.422447476564186	no	2098	0.414168039715784	1409	NA	FT	CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION			Protein kinase, related to and functionally redundant with Elm1p and Sak1p for the phosphorylation and activation of Snf1p; functionally orthologous to LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome	protein phosphorylation|glucose metabolic process	protein serine/threonine kinase activity|protein kinase activity	nucleus|cytoplasm
YLR394W	YLR394W	CST9	hom	Verified	0.195334835411524	0.422565413788318	no	2099	0.429919961805405	1428	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		SUMO E3 ligase; required for synaptonemal complex formation; localizes to synapsis initiation sites on meiotic chromosomes; potential Cdc28p substrate	synaptonemal complex assembly|protein sumoylation|synapsis|reciprocal meiotic recombination	SUMO ligase activity	condensed nuclear chromosome|nuclear chromosome
YDR117C	YDR117C	TMA64	hom	Verified	0.19336318337017	0.423337273345084	no	2100	0.412557240153457	1364	NA	FT	TRANSLATION			Protein of unknown function that associates with ribosomes; has a putative RNA binding domain; in mammals the corresponding protein, eIF2D, has been shown to possess translation initiation factor activity	biological_process	RNA binding	ribosome
YML068W	YML068W	ITT1	hom	Verified	0.193008295263032	0.423476235780172	no	2101	0.412257855907923	1392	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION			Protein that modulates the efficiency of translation termination, interacts with translation release factors eRF1 (Sup45p) and eRF3 (Sup35p) in vitro, contains a zinc finger domain characteristic of the TRIAD class of proteins	regulation of translational termination	molecular_function	cellular_component
YAR023C_p	YAR023C	YAR023C	hom	Uncharacterized	0.192503980772886	0.423673725010738	no	2102	0.427067546441499	1404	NA					Putative integral membrane protein, member of DUP240 gene family	biological_process	molecular_function	cellular_component
YMR199W	YMR199W	CLN1	hom	Verified	0.191236829028634	0.42417002532507	no	2103	0.4118369982744	1339	NA	FT	CELL CYCLE|CELL DIVISION|PROTEIN PHOSPHORYLATION	NUCLEUS		G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p)	regulation of cyclin-dependent protein kinase activity	cyclin-dependent protein kinase regulator activity	nucleus|cytoplasm
YPL112C	YPL112C	PEX25	hom	Verified	0.191069392317428	0.424235613613247	no	2104	0.431974169922369	1429	NA	FT	PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION			Peripheral peroxisomal membrane peroxin required for the regulation of peroxisome size and maintenance, recruits GTPase Rho1p to peroxisomes, induced by oleate, interacts with homologous protein Pex27p	protein import into peroxisome matrix|peroxisome organization	molecular_function	peroxisomal membrane
YJL049W_p	YJL049W	YJL049W	hom	Uncharacterized	0.19081960473128	0.42433346427579	no	2105	0.38651708147717	1278	NA	FT	PROTEIN LOCALIZATION			Putative protein of unknown function; YJL049W is a non-essential gene	biological_process	molecular_function	cellular_component
YNL229C	YNL229C	URE2	hom	Verified	0.190454014341586	0.424476687413504	no	2106	0.449994026289216	1475	NA	FF|FT	PROTEIN LOCALIZATION			Nitrogen catabolite repression transcriptional regulator that acts by inhibition of GLN3 transcription in good nitrogen source; has glutathione peroxidase activity and can mutate to acquire GST activity; altered form creates [URE3] prion	regulation of nitrogen utilization|response to aluminum ion|protein urmylation|cytoplasmic sequestering of transcription factor	glutathione peroxidase activity|phosphoprotein binding|transcription corepressor activity	cytosol
YGR232W	YGR232W	NAS6	hom	Verified	0.190268509201675	0.42454936444146	no	2107	0.426409158582655	1419	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS	NUCLEUS		Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); ortholog of human oncoprotein gankyrin, which interacts with the Rb tumor suppressor and CDK4/6	proteolysis|proteasome regulatory particle assembly	molecular_function	cytosol|nucleus|proteasome regulatory particle
YMR311C	YMR311C	GLC8	hom	Verified	0.190051303723624	0.424634464257923	no	2108	0.433765237768418	1424	NA	FT	SIGNALING|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|CHROMOSOME SEGREGATION	NUCLEUS		Regulatory subunit of protein phosphatase 1 (Glc7p); involved in glycogen metabolism and chromosome segregation; proposed to regulate Glc7p activity via conformational alteration; ortholog of the mammalian protein phosphatase inhibitor 2; protein abundance increases in response to DNA replication stress	chromosome segregation|glycogen biosynthetic process	enzyme activator activity	nucleus|cytoplasm
YLR201C	YLR201C	COQ9	hom	Verified	0.189890198625318	0.424697586548122	no	2109	0.420083981490246	1371	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes	ubiquinone biosynthetic process|aerobic respiration	molecular_function	mitochondrion|mitochondrial inner membrane
YBR182C-A_p	YBR182C-A	YBR182C-A	hom	Uncharacterized	0.189846301047241	0.42471478631173	no	2110	0.431493724642	1431	NA					Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching	biological_process	molecular_function	cellular_component
YDR085C	YDR085C	AFR1	hom	Verified	0.189344951835237	0.424911233001209	no	2111	0.423781553853592	1394	NA	FT	SIGNALING			Protein required for pheromone-induced projection (shmoo) formation; regulates septin architecture during mating; has an RVXF motif that mediates targeting of Glc7p to mating projections; interacts with Cdc12p; AFR1 has a paralog, YER158C, that arose from the whole genome duplication	regulation of G-protein coupled receptor protein signaling pathway|pheromone-dependent signal transduction involved in conjugation with cellular fusion|cell morphogenesis involved in conjugation with cellular fusion|cell morphogenesis involved in conjugation	receptor signaling protein activity	mating projection base
YOL081W	YOL081W	IRA2	hom	Verified	0.188772879927797	0.425135414169638	no	2112	0.411162062157036	1366	NA	FT	SIGNALING|NUCLEOTIDE METABOLISM	MITOCHONDRION|PLASMA MEMBRANE		GTPase-activating protein; negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions; similar to human neurofibromin; IRA2 has a paralog, IRA1, that arose from the whole genome duplication	negative regulation of cAMP biosynthetic process|negative regulation of Ras protein signal transduction|positive regulation of Ras GTPase activity|response to stress	Ras GTPase activator activity	mitochondrion|integral to membrane|cytoplasm
YHR004C	YHR004C	NEM1	hom	Verified	0.188685547997625	0.42516963957642	no	2113	0.416160067110398	1348	NA	FF|FT	LIPID METABOLISM|MEMBRANE ORGANIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|MITOCHONDRION		Probable catalytic subunit of Nem1p-Spo7p phosphatase holoenzyme; regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology and sporulation; homolog of the human protein Dullard	negative regulation of phospholipid biosynthetic process|nuclear envelope organization	phosphoprotein phosphatase activity	Nem1-Spo7 phosphatase complex|mitochondrion|integral to membrane
YKL073W	YKL073W	LHS1	hom	Verified	0.187348608701339	0.425693656697299	no	2114	0.436107437710334	1446	NA	FT	PROTEIN LOCALIZATION|NUCLEOTIDE METABOLISM	ENDOPLASMIC RETICULUM		Molecular chaperone of the endoplasmic reticulum lumen, involved in polypeptide translocation and folding; nucleotide exchange factor for the ER lumenal Hsp70 chaperone Kar2p; regulated by the unfolded protein response pathway	posttranslational protein targeting to membrane, translocation|response to unfolded protein	unfolded protein binding|adenyl-nucleotide exchange factor activity|ATP binding	endoplasmic reticulum lumen
YDR204W	YDR204W	COQ4	hom	Verified	0.187344116792754	0.425695417535284	no	2115	0.420699831204764	1386	NA	FT	KETONE METABOLISM|COFACTOR METABOLISM	MITOCHONDRION		Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex	ubiquinone biosynthetic process	molecular_function	mitochondrial inner membrane
YFR038W	YFR038W	IRC5	hom	Verified	0.186417234613646	0.426058789024464	no	2116	0.403407324259104	1333	NA	FT		NUCLEUS		Putative ATPase containing the DEAD/H helicase-related sequence motif; null mutant displays increased levels of spontaneous Rad52p foci	mitotic recombination	molecular_function	cellular_component
YBR064W_d	YBR064W	YBR064W	hom	Dubious	0.184481887837404	0.426817717356053	no	2117	0.413951720755718	1389	NA					Dubious open reading frame unlikely to encode a protein; partially overlaps the uncharacterized ORF YBR063C	Unknown	Unknown	Unknown
YOL086W-A	YOL086W-A	MHF1	hom	Verified	0.183251047599263	0.427300521128277	no	2118	0.416972881358702	1401	NA	FT	RESPONSE TO DNA DAMAGE			Component of the heterotetrameric MHF histone-fold complex; in humans the MMF complex interacts with both DNA and Mph1p ortholog FANCM, a Fanconi anemia complementation group protein, to stabilize and remodel blocked replication forks and repair damaged DNA; mhf1 srs2 double mutants are MMS hypersensitive; ortholog of human centromere constitutive-associated network (CCAN) subunit CENP-S, also known as MHF1	response to DNA damage stimulus	molecular_function	cellular_component
YDR539W	YDR539W	FDC1	hom	Verified	0.182998418883021	0.427399629609127	no	2119	0.421338700645418	1424	NA	FT	KETONE METABOLISM|COFACTOR METABOLISM	PLASMA MEMBRANE		Putative phenylacrylic acid decarboxylase; essential for the decarboxylation of aromatic carboxylic acids to the corresponding vinyl derivatives; homolog of E. coli UbiD; GFP-fusion protein localizes to the cytoplasm	cinnamic acid catabolic process	molecular_function	cytoplasm
YCR016W_p	YCR016W	YCR016W	hom	Uncharacterized	0.182859305697021	0.427454206899622	no	2120	0.398276741391629	1335	NA	FT		NUCLEUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus and nucleus; predicted to be involved in ribosome biogenesis	biological_process	molecular_function	nucleolus|nucleus
YPR062W	YPR062W	FCY1	hom	Verified	0.182834471433846	0.427463950096192	no	2121	0.436589436966084	1427	NA	FT		NUCLEUS		Cytosine deaminase, zinc metalloenzyme that catalyzes the hydrolytic deamination of cytosine to uracil; of biomedical interest because it also catalyzes the deamination of 5-fluorocytosine (5FC) to form anticancer drug 5-fluorouracil (5FU)	cytosine metabolic process|pyrimidine-containing compound salvage|cytidine metabolic process	cytosine deaminase activity	nucleus|cytoplasm
YOL035C_d	YOL035C	YOL035C	hom	Dubious	0.182457100954026	0.427612008842491	no	2122	0.419155006178378	1381	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YMR009W	YMR009W	ADI1	hom	Verified	0.181690449899764	0.427912830552079	no	2123	0.417169027242214	1372	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS	NUCLEUS		Acireductone dioxygenease involved in the methionine salvage pathway; ortholog of human MTCBP-1; transcribed as polycistronic mRNA with YMR010W and regulated post-transcriptionally by RNase III (Rnt1p) cleavage; ADI1 mRNA is induced in heat shock conditions	L-methionine salvage from methylthioadenosine	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	nucleus|cytoplasm
YOR364W_d	YOR364W	YOR364W	hom	Dubious	0.180403283103002	0.428417988534334	no	2124	0.417163600830163	1366	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR365C	Unknown	Unknown	Unknown
YJL159W	YJL159W	HSP150	hom	Verified	0.180313322556922	0.428453298601252	no	2125	0.415725765619345	1368	NA	FT	CELL WALL ORG/BIOGENESIS			O-mannosylated heat shock protein; secreted and covalently attached to the cell wall via beta-1,3-glucan and disulfide bridges; required for cell wall stability; induced by heat shock, oxidative stress, and nitrogen limitation; HSP150 has a paralog, PIR3, that arose from the whole genome duplication	fungal-type cell wall organization	structural constituent of cell wall|ATPase activity	fungal-type cell wall|extracellular region
YLR443W	YLR443W	ECM7	hom	Verified	0.180267923196451	0.428471118346584	no	2126	0.428517592715476	1437	NA	FT	ION HOMEOSTASIS|CELL WALL ORG/BIOGENESIS|ION HOMEOSTASIS			Non-essential putative integral membrane protein with a role in calcium uptake; mutant has cell wall defects and Ca+ uptake deficiencies; transcription is induced under conditions of zinc deficiency	fungal-type cell wall organization|calcium ion transport	molecular_function	integral to membrane
YJL162C	YJL162C	JJJ2	hom	Verified	0.179596127207348	0.428734822643658	no	2127	0.419994032002492	1380	NA	FT		NUCLEUS		Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein	biological_process	molecular_function	nucleus|cytoplasm
YCR061W_p	YCR061W	YCR061W	hom	Uncharacterized	0.17882461672674	0.429037707742093	no	2128	0.431343483408949	1453	NA					Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; induced by treatment with 8-methoxypsoralen and UVA irradiation	regulation of cell size	molecular_function	integral to membrane|cytoplasm
YNR009W	YNR009W	NRM1	hom	Verified	0.177548812034182	0.429538663875144	no	2129	0.425511452873425	1397	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE	NUCLEUS		Transcriptional co-repressor of MBF (MCB binding factor)-regulated gene expression; Nrm1p associates stably with promoters via MBF to repress transcription upon exit from G1 phase	negative regulation of transcription involved in G1 phase of mitotic cell cycle	repressing transcription factor binding|transcription factor binding transcription factor activity	MBF transcription complex|nucleus|cytoplasm
YGR079W_p	YGR079W	YGR079W	hom	Uncharacterized	0.17736676644774	0.429610154974873	no	2130	0.447279745823113	1489	NA					Putative protein of unknown function; YGR079W is not an essential gene	biological_process	molecular_function	cellular_component
YMR300C	YMR300C	ADE4	hom	Verified	0.177072043003924	0.429725900674801	no	2131	0.436116917705641	1443	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEOTIDE METABOLISM			Phosphoribosylpyrophosphate amidotransferase (PRPPAT; amidophosphoribosyltransferase), catalyzes first step of the 'de novo' purine nucleotide biosynthetic pathway	'de novo' IMP biosynthetic process	amidophosphoribosyltransferase activity	cytoplasm
YCR024C-A	YCR024C-A	PMP1	hom	Verified	0.173982556626946	0.430939585474243	no	2132	0.441593910999491	1433	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Regulatory subunit for the plasma membrane H(+)-ATPase Pma1p; small single-membrane span proteolipid; forms unique helix and positively charged cytoplasmic domain that is able to specifically segregate phosphatidylserines; PMP1 has a paralog, PMP2, that arose from the whole genome duplication	cation transport	enzyme regulator activity	plasma membrane|membrane
YLR415C_p	YLR415C	YLR415C	hom	Uncharacterized	0.173233092009971	0.431234106593672	no	2133	0.431727702199122	1429	NA	FT		MITOCHONDRION		Putative protein of unknown function; YLR415C is not an essential gene	biological_process	molecular_function	cellular_component
YLR425W	YLR425W	TUS1	hom	Verified	0.172576721943615	0.431492075265721	no	2134	0.4946139720486	1656	NA	FT	SIGNALING|CELL WALL ORG/BIOGENESIS	SITE OF POLARIZED GROWTH		Guanine nucleotide exchange factor (GEF) that modulate Rho1p activity; involved in the cell integrity signaling pathway; interacts with Rgl1p; localization of Tus1p to the bed neck is regulated by Rgl1p; multicopy suppressor of tor2 mutation and ypk1 ypk2 double mutation; potential Cdc28p substrate	fungal-type cell wall organization|signal transduction	Rho guanyl-nucleotide exchange factor activity	incipient cellular bud site|cellular bud neck
YOR162C	YOR162C	YRR1	hom	Verified	0.17237918173676	0.431569718878209	no	2135	0.477147275265881	1582	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		Zn2-Cys6 zinc-finger transcription factor; activates genes involved in multidrug resistance; paralog of Yrm1p, acting on an overlapping set of target genes; YRR1 has a paralog, PDR8, that arose from the whole genome duplication	regulation of transcription from RNA polymerase II promoter in response to oxidative stress|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity	nucleus
YBR181C	YBR181C	RPS6B	hom	Verified	0.17222884542382	0.431628810668345	no	2136	0.43911372840151	1456	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S6, no bacterial homolog; RPS6B has a paralog, RPS6A, that arose from the whole genome duplication	cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome	small-subunit processome|cytosolic small ribosomal subunit|cytoplasm
YKR010C	YKR010C	TOF2	hom	Verified	0.171578706027286	0.431884374648983	no	2137	0.425761549200273	1428	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|CHROMOSOME SEGREGATION|GENE SILENCING	NUCLEUS|MITOCHONDRION		Protein required for rDNA silencing and mitotic rDNA condensation; stimulates Cdc14p phosphatase activity and biphasic release to promote rDNA repeat segregation; required for condensin recruitment to the replication fork barrier site; TOF2 has a paralog, NET1, that arose from the whole genome duplication	nucleolus organization|rDNA condensation|chromatin silencing at rDNA|protein localization to nucleolar rDNA repeats	phosphatase activator activity	mitochondrion|nucleolus
YDR250C_d	YDR250C	YDR250C	hom	Dubious	0.170054536060114	0.43248362380856	no	2138	0.433171635353583	1444	NA					Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data	Unknown	Unknown	Unknown
YDL240W	YDL240W	LRG1	hom	Verified	0.170040599399691	0.432489103924117	no	2139	0.439722508810026	1464	NA	FT	SIGNALING|CELL WALL ORG/BIOGENESIS	MITOCHONDRION|SITE OF POLARIZED GROWTH		Putative GTPase-activating protein (GAP) involved in the Pkc1p-mediated signaling pathway that controls cell wall integrity; appears to specifically regulate 1,3-beta-glucan synthesis	fungal-type cell wall biogenesis|small GTPase mediated signal transduction	Rho GTPase activator activity	mitochondrion|cellular bud neck|cytoplasm
YHR156C	YHR156C	LIN1	hom	Verified	0.169712547196579	0.432618102993327	no	2140	0.436222804814661	1453	NA	FT		NUCLEUS|CHROMOSOME		Non-essential component of U5 snRNP; nuclear protein; physically interacts with Irr1p of cohesin complex; may link together proteins involved in chromosome segregation, mRNA splicing and DNA replication	biological_process	protein binding	chromatin|nucleus|U4/U6 x U5 tri-snRNP complex|U5 snRNP
YOL059W	YOL059W	GPD2	hom	Verified	0.169500282957607	0.432701574906472	no	2141	0.453832170112345	1495	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM	MITOCHONDRION		NAD-dependent glycerol 3-phosphate dehydrogenase, homolog of Gpd1p, expression is controlled by an oxygen-independent signaling pathway required to regulate metabolism under anoxic conditions; located in cytosol and mitochondria; constitutively active but is inactivated via phosphorylation by energy-stress responsive kinase SNF1	NADH oxidation|glycerol metabolic process	glycerol-3-phosphate dehydrogenase [NAD+] activity	cytosol|mitochondrion
YDR124W_p	YDR124W	YDR124W	hom	Uncharacterized	0.168897816894613	0.432938508197641	no	2142	0.424563669918892	1383	NA					Putative protein of unknown function; non-essential gene; expression is strongly induced by alpha factor	biological_process	molecular_function	cellular_component
YJL079C	YJL079C	PRY1	hom	Verified	0.167890255871504	0.433334808003686	no	2143	0.398543507230066	1323	NA	FT		ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM		Sterol binding protein involved in the export of acetylated sterols; secreted glycoprotein and member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis related 1 proteins); sterol export function is redundant with that of PRY2; may be involved in detoxification of hydrophobic compounds; PRY1 has a paralog, PRY2, that arose from the whole genome duplication	biological_process	molecular_function	nuclear envelope|extracellular region|endoplasmic reticulum|fungal-type vacuole
YER014W	YER014W	HEM14	hom	Verified	0.167059460059927	0.43366163193037	no	2144	0.441178524172773	1459	NA	FT	OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM	MITOCHONDRION		Protoporphyrinogen oxidase, a mitochondrial enzyme that catalyzes the seventh step in the heme biosynthetic pathway, converting protoporphyrinogen IX to protoporphyrin IX; inhibited by diphenyl ether-type herbicides	heme biosynthetic process	oxygen-dependent protoporphyrinogen oxidase activity	mitochondrion|mitochondrial inner membrane
YER162C	YER162C	RAD4	hom	Verified	0.166708533314999	0.433799695444336	no	2145	0.436184595609752	1444	NA	FT	RESPONSE TO DNA DAMAGE|PROTEOLYSIS	NUCLEUS		Protein that recognizes and binds damaged DNA (with Rad23p) during nucleotide excision repair; subunit of Nuclear Excision Repair Factor 2 (NEF2); also involved, with Rad23p, in turnover of ubiquitylated proteins	proteasomal ubiquitin-dependent protein catabolic process|nucleotide-excision repair	damaged DNA binding	cytosol|nucleotide-excision repair factor 2 complex|nucleus
YML101C-A_d	YML101C-A	YML101C-A	hom	Dubious	0.166625915819015	0.43383220044547	no	2146	0.439321021410482	1424	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YOL147C	YOL147C	PEX11	hom	Verified	0.165406065793568	0.434312189812727	no	2147	0.428372576235816	1392	NA	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|PEROXISOME ORGANIZATION	ENDOPLASMIC RETICULUM		Peroxisomal membrane protein required for medium-chain fatty acid oxidation and peroxisome proliferation, possibly by inducing membrane curvature; localization regulated by phosphorylation; transcription regulated by Adr1p and Pip2p-Oaf1p	peroxisome fission|fatty acid oxidation	molecular_function	endoplasmic reticulum|peroxisomal membrane
YLR267W_p	YLR267W	BOP2	hom	Uncharacterized	0.165154393630926	0.434411230424477	no	2148	0.407786382080863	1345	NA					Protein of unknown function	biological_process	molecular_function	cellular_component
YOL063C	YOL063C	CRT10	hom	Verified	0.164108989366591	0.434822672633717	no	2149	0.427785102815046	1397	NA	FT	TRANSCRIPTION FROM RNA POL II			Protein involved in transcriptional regulation of RNR2 and RNR3; expression of the gene is induced by DNA damage and null mutations confer increased resistance to hydroxyurea; N-terminal region has a leucine repeat and a WD40 repeat	regulation of transcription from RNA polymerase II promoter	molecular_function	cellular_component
YER110C	YER110C	KAP123	hom	Verified	0.163321473425089	0.435132663773841	no	2150	0.398157195286592	1349	NA	FT	PROTEIN LOCALIZATION|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	Karyopherin beta, mediates nuclear import of ribosomal proteins prior to assembly into ribosomes and import of histones H3 and H4; localizes to the nuclear pore, nucleus, and cytoplasm; exhibits genetic interactions with RAI1	NLS-bearing substrate import into nucleus|Unknown|protein import into nucleus|ribosomal protein import into nucleus	protein transporter activity|nuclear localization sequence binding	integral to membrane|nucleus|nuclear pore|cytoplasm
YJL102W	YJL102W	MEF2	hom	Verified	0.163175056279912	0.435190302586661	no	2151	0.440466214555773	1459	NA	FT	TRANSLATION|NUCLEOTIDE METABOLISM	MITOCHONDRION		Mitochondrial elongation factor involved in translationa