strainid	orf	gene	zyg	qualifier	SGTC_952|1185-0122.score	SGTC_952|1185-0122.expt.zyg.pval	SGTC_952|1185-0122.expt.zyg.significant	SGTC_952|1185-0122.expt.zyg.rank	strain.pval	strain.rank	clearance	Fclass	Fterms.BP	Fterms.CC	Fterms.complex	description	GO_process	GO_function	GO_component
YBR018C	YBR018C	GAL7	hom	Verified	7.66589852768656	8.87917753335081e-15	yes	1	4.04300081062993e-16	1	NA	FT	CARBOHYDRATE METABOLISM			Galactose-1-phosphate uridyl transferase, synthesizes glucose-1-phosphate and UDP-galactose from UDP-D-glucose and alpha-D-galactose-1-phosphate in the second step of galactose catabolism	galactose catabolic process via UDP-galactose	UDP-glucose:hexose-1-phosphate uridylyltransferase activity	cytoplasm
YGR255C	YGR255C	COQ6	hom	Verified	7.5354688518429	2.4329166650949e-14	yes	2	9.95125726727784e-14	14	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM	MITOCHONDRION		Putative flavin-dependent monooxygenase; involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; human COX6 can rescue a yeast cox6 mutant and is implicated in steroid-resistant nephrotic syndrome (SRNS)	ubiquinone biosynthetic process	N,N-dimethylaniline monooxygenase activity	mitochondrion|mitochondrial inner membrane
YER092W	YER092W	IES5	hom	Verified	7.52401026820656	2.65605851016951e-14	yes	3	2.01004182776579e-12	1	NA	FT		NUCLEUS		Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions	biological_process	molecular_function	nucleus
YKL126W	YKL126W	YPK1	hom	Verified	7.28381847348445	1.62250794547017e-13	yes	4	7.1356845722863e-05	136	NA	FF|FT	VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS|PROTEIN PHOSPHORYLATION	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Serine/threonine protein kinase; phosphorylates and downregulates flippase activator Fpk1p; inactivates Orm1p and Orm2p (inhibitors of serine:palmitoyl-coenzyme A transferase) by phosphorylation in response to compromised sphingolipid synthesis; mutations affect receptor-mediated endocytosis and sphingolipid-mediated and cell integrity signaling pathways; homolog of mammalian kinase SGK; YPK1 has a paralog, YPK2, that arose from the whole genome duplication	eisosome assembly|protein autophosphorylation|negative regulation of phospholipid translocation|protein phosphorylation	protein serine/threonine kinase activity	cytosol|plasma membrane|cellular bud neck
YAR014C	YAR014C	BUD14	hom	Verified	7.04838471889433	9.05033089203907e-13	yes	5	2.13315559341029e-13	3	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH		Protein involved in bud-site selection; Bud14p-Glc7p complex is a cortical regulator of dynein; inhibitor of the actin assembly factor Bnr1p (formin); diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; relative distribution to the nucleus increases upon DNA replication stress	regulation of cell shape during vegetative growth phase|regulation of protein localization|regulation of transcription, DNA-dependent|cytoskeleton organization|negative regulation of actin filament polymerization	protein phosphatase type 1 regulator activity	incipient cellular bud site|cellular bud neck|cellular bud tip
YNL160W	YNL160W	YGP1	hom	Verified	6.25050842216393	2.04559335218162e-10	yes	6	6.8651303573861e-11	1	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|CELL WALL ORG/BIOGENESIS			Cell wall-related secretory glycoprotein; induced by nutrient deprivation-associated growth arrest and upon entry into stationary phase; may be involved in adaptation prior to stationary phase entry; has similarity to Sps100p	cell wall assembly	molecular_function	extracellular region
YLR434C_d	YLR434C	YLR434C	hom	Dubious	5.74959525905796	4.47286699107433e-09	yes	7	3.09027363134574e-08	2	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF TSR2/YLR435W	Unknown	Unknown	Unknown
YDR525W-A	YDR525W-A	SNA2	hom	Verified	5.20206451514012	9.85433898638475e-08	yes	8	9.78650914966394e-08	8	NA					Protein of unknown function, has similarity to Pmp3p, which is involved in cation transport; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern	biological_process	molecular_function	fungal-type vacuole membrane|integral to membrane|cytoplasm
YGR079W_p	YGR079W	YGR079W	hom	Uncharacterized	5.16502562503384	1.20202992689248e-07	yes	9	1.5292694337128e-08	4	NA					Putative protein of unknown function; YGR079W is not an essential gene	biological_process	molecular_function	cellular_component
YOR359W	YOR359W	VTS1	hom	Verified	4.69324865664186	1.34450157126211e-06	yes	10	4.90452485875015e-06	5	NA	FT	PROTEIN LOCALIZATION|RNA PROCESSING	NUCLEUS		Flap-structured DNA-binding and RNA-binding protein; stimulates deadenylation-dependent mRNA degradation mediated by the CCR4-NOT deadenylase complex; member of the Smaug (Smg) family of post-transcriptional regulators which bind RNA through a conserved sterile alpha motif (SAM) domain that interacts with Smg recognition element (SREs) containing transcripts; stimulates Dna2p endonuclease activity	nuclear-transcribed mRNA catabolic process|positive regulation of endodeoxyribonuclease activity|nuclear-transcribed mRNA poly(A) tail shortening	flap-structured DNA binding|RNA binding	cytosol|nucleus|cytoplasmic mRNA processing body
YPR124W	YPR124W	CTR1	hom	Verified	4.68037677649044	1.43174089063261e-06	yes	11	0.000527796534737011	72	NA	FF|FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		High-affinity copper transporter of the plasma membrane; mediates nearly all copper uptake under low copper conditions; transcriptionally induced at low copper levels and degraded at high copper levels; protein increases in abundance and relocalizes from nucleus to plasma membrane upon DNA replication stress	copper ion import	copper uptake transmembrane transporter activity	integral to membrane|plasma membrane
YGR163W	YGR163W	GTR2	hom	Verified	4.49962013347779	3.40375000515817e-06	yes	12	9.74987829405671e-05	45	NA	FF|FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|MEMBRANE ORGANIZATION	NUCLEUS|CHROMOSOME		Putative GTP binding protein that negatively regulates Ran/Tc4 GTPase cycle; activates transcription; subunit of EGO and GSE complexes; required for sorting of Gap1p; localizes to cytoplasm and to chromatin; homolog of human RagC and RagD	microautophagy|positive regulation of transcription from RNA polymerase II promoter	GTP binding	nuclear chromatin|fungal-type vacuole membrane|integral to membrane|EGO complex|nucleus|late endosome membrane|cytoplasm
YHR041C	YHR041C	SRB2	hom	Verified	4.38430890888437	5.8177283551432e-06	yes	13	6.5695130454785e-05	28	NA	FT	TRANSCRIPTION FROM RNA POL II|RIBOSOME BIOGENESIS|RESPONSE TO NUTRIENT LEVELS	NUCLEUS	RNA POL II, HOLOENZYME	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; general transcription factor involved in telomere maintenance	negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter in response to chemical stimulus|RNA polymerase II transcriptional preinitiation complex assembly|negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter in response to nutrient levels|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly|core RNA polymerase II binding transcription factor activity|RNA polymerase II transcription factor recruiting transcription factor activity|TBP-class protein binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly|protein domain specific binding	core mediator complex
YDL046W	YDL046W	NPC2	hom	Verified	4.34252706086589	7.04265648787165e-06	yes	14	5.27199427896652e-06	4	NA					Functional homolog of human NPC2/He1, which is a cholesterol-binding protein whose deficiency causes Niemann-Pick type C2 disease involving retention of cholesterol in lysosomes	intracellular sterol transport	molecular_function	fungal-type vacuole lumen|fungal-type vacuole
YDL100C	YDL100C	GET3	hom	Verified	4.1417124092189	1.72361209629573e-05	yes	15	0.000898177993728747	68	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING|NUCLEOTIDE METABOLISM	ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Guanine nucleotide exchange factor for Gpa1p; amplifies G protein signaling; subunit of the GET complex, which is involved in Golgi to ER trafficking and insertion of proteins into the ER membrane; has low-level ATPase activity; protein abundance increases in response to DNA replication stress	retrograde vesicle-mediated transport, Golgi to ER|pheromone-dependent signal transduction involved in conjugation with cellular fusion|response to heat|protein insertion into ER membrane|response to metal ion|posttranslational protein targeting to membrane	ATPase activity|guanyl-nucleotide exchange factor activity	endoplasmic reticulum|GET complex
YIL009C-A	YIL009C-A	EST3	hom	Verified	4.11336367802549	1.94967673419663e-05	yes	16	4.51380899017937e-05	11	NA	FT		NUCLEUS|CHROMOSOME		Component of the telomerase holoenzyme, involved in telomere replication	telomere maintenance via telomerase	ATP-dependent DNA/RNA helicase activity|GTPase activity|telomeric DNA binding	chromosome, telomeric region|nucleus|telomerase holoenzyme complex
YLR384C	YLR384C	IKI3	hom	Verified	4.0127949529203	3.00020161905172e-05	yes	17	2.52595000536866e-05	18	NA	FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|RNA PROCESSING	NUCLEUS		Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator; homolog of human IKAP, mutations in which cause familial dysautonomia (FD)	regulation of transcription from RNA polymerase II promoter|tRNA wobble uridine modification	molecular_function	Elongator holoenzyme complex|nucleus|cytoplasm
YNL067W-B_p	YNL067W-B	YNL067W-B	hom	Uncharacterized	3.99795834161204	3.1945595996048e-05	yes	18	7.77549363661172e-05	5	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YCL061C	YCL061C	MRC1	hom	Verified	3.97870764800551	3.4645439912883e-05	yes	19	0.000134658467683311	25	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION|GENE SILENCING	NUCLEUS|CHROMOSOME		S-phase checkpoint protein required for DNA replication; interacts with and stabilizes Pol2p at stalled replication forks during stress, where it forms a pausing complex with Tof1p and is phosphorylated by Mec1p; protects uncapped telomeres	maintenance of DNA repeat elements|intra-S DNA damage checkpoint|DNA repair|DNA replication checkpoint|telomere maintenance|replication fork protection|DNA replication|mitotic sister chromatid cohesion|chromatin silencing at silent mating-type cassette|chromatin silencing at telomere	molecular_function	nuclear chromosome|replication fork protection complex|nucleus|nuclear replication fork
YKR036C	YKR036C	CAF4	hom	Verified	3.95975224662589	3.75137796243253e-05	yes	20	2.77500673759342e-05	10	NA	FT	TRANSCRIPTION FROM RNA POL II|MITOCHONDRION ORGANIZATION|PEROXISOME ORGANIZATION	NUCLEUS|MITOCHONDRION		WD40 repeat-containing protein associated with the CCR4-NOT complex; interacts in a Ccr4p-dependent manner with Ssn2p; also interacts with Fis1p, Mdv1p and Dnm1p and plays a role in mitochondrial fission; CAF4 has a paralog, MDV1, that arose from the whole genome duplication	peroxisome fission|mitochondrial fission|regulation of transcription from RNA polymerase II promoter	molecular_function	mitochondrion|CCR4-NOT complex
YEL039C	YEL039C	CYC7	hom	Verified	3.91760933895473	4.47157425777993e-05	yes	21	0.000170703876406029	20	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Cytochrome c isoform 2, expressed under hypoxic conditions; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration; protein abundance increases in response to DNA replication stress; CYC7 has a paralog, CYC1, that arose from the whole genome duplication	mitochondrial electron transport, cytochrome c to oxygen|mitochondrial electron transport, ubiquinol to cytochrome c	electron carrier activity	mitochondrion|mitochondrial intermembrane space
YHR100C	YHR100C	GEP4	hom	Verified	3.84545542347828	6.01643695055882e-05	yes	22	0.00156187209671333	94	NA	FF|FT	LIPID METABOLISM|CARBOHYDRATE METABOLISM	MITOCHONDRION		Mitochondrial phosphatidylglycerophosphatase (PGP phosphatase), dephosphorylates phosphatidylglycerolphosphate to generate phosphatidylglycerol, an essential step during cardiolipin biosynthesis; null mutant is sensitive to tunicamycin, DTT	cardiolipin biosynthetic process|phosphorylated carbohydrate dephosphorylation	phosphatidylglycerophosphatase activity	mitochondrion|mitochondrial matrix
YDR383C	YDR383C	NKP1	hom	Verified	3.74011802741505	9.19669329829001e-05	yes	23	9.64784437557608e-05	19	NA	FT	CELL CYCLE|CELL DIVISION	NUCLEUS|CHROMOSOME	KINETOCHORE	Central kinetochore protein and subunit of the Ctf19 complex; mutants have elevated rates of chromosome loss; orthologous to fission yeast kinetochore protein fta4	biological_process	molecular_function	kinetochore
YBL071C_d	YBL071C	YBL071C	hom	Dubious	3.68986159942037	0.000112188044313648	yes	24	0.000149395704028533	27	NA					Dubious open reading frame, predicted protein contains a peroxisomal targeting signal	Unknown	Unknown	Unknown
YLR093C	YLR093C	NYV1	hom	Verified	3.66623117764326	0.000123075709631205	yes	25	6.5480423351012e-05	10	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION			v-SNARE component of the vacuolar SNARE complex involved in vesicle fusion; inhibits ATP-dependent Ca(2+) transport activity of Pmc1p in the vacuolar membrane	vesicle-mediated transport|vacuole fusion, non-autophagic|vesicle fusion	SNAP receptor activity	SNARE complex|fungal-type vacuole membrane
YER169W	YER169W	RPH1	hom	Verified	3.63107091301687	0.000141123806189822	yes	26	0.000311127337306942	22	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION	NUCLEUS		JmjC domain-containing histone demethylase; specifically demethylates H3K36 tri- and dimethyl modification states; associates with actively transcribed (RNA polymerase II) regions in vivo and specifically targets H3K36 in its trimethylation state as its substrate; transcriptional repressor of PHR1; Rph1p phosphorylation during DNA damage is under control of the MEC1-RAD53 pathway; RPH1 has a paralog, GIS1, that arose from the whole genome duplication	negative regulation of transcription from RNA polymerase II promoter|histone demethylation	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|sequence-specific DNA binding|histone demethylase activity (H3-K36 specific)|histone demethylase activity (H3-K9 specific)	nucleus
YGL064C	YGL064C	MRH4	hom	Verified	3.62486597666196	0.000144555671376473	yes	27	0.000261101219648438	32	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS	MITOCHONDRION		Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function	RNA metabolic process	RNA helicase activity	mitochondrion
YLR204W	YLR204W	QRI5	hom	Verified	3.58708012685629	0.000167200794649059	yes	28	0.00193026370913476	69	NA	FF|FT	RNA PROCESSING	MITOCHONDRION		Mitochondrial inner membrane protein, required for accumulation of spliced COX1 mRNA; may have an additional role in translation of COX1 mRNA	mRNA processing	molecular_function	mitochondrion|integral to mitochondrial inner membrane
YLR054C	YLR054C	OSW2	hom	Verified	3.58137644198595	0.000170894385225654	yes	29	0.000215649788265907	9	NA	FT	CELL WALL ORG/BIOGENESIS			Protein of unknown function proposed to be involved in the assembly of the spore wall	ascospore wall assembly	molecular_function	integral to membrane|prospore membrane|cytoplasm
YLR217W_d	YLR217W	YLR217W	hom	Dubious	3.57380882680906	0.000175912921706923	yes	30	0.000227877268151002	8	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CPR6	Unknown	Unknown	Unknown
YFL050C	YFL050C	ALR2	hom	Verified	3.54659405766462	0.000195122704193428	yes	31	0.000308803493660544	13	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Probable Mg(2+) transporter; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions; plays a role in regulating Ty1 transposition	magnesium ion transport|cation transport|transmembrane transport	inorganic cation transmembrane transporter activity	integral to membrane|plasma membrane
YDR509W_d	YDR509W	YDR509W	hom	Dubious	3.53628147438183	0.000202901036754235	yes	32	0.000333261098827227	41	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDL018C	YDL018C	ERP3	hom	Verified	3.50946789505609	0.000224502130864546	yes	33	0.00055233420817843	19	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport	vesicle-mediated transport	molecular_function	integral to membrane
YKL157W	YKL157W	APE2	hom	Verified	3.50202386519965	0.000230869128789866	yes	34	0.000312713918433068	21	NA	FT	PROTEOLYSIS	MITOCHONDRION		Aminopeptidase yscII; may have a role in obtaining leucine from dipeptide substrates; APE2 has a paralog, AAP1, that arose from the whole genome duplication	peptide catabolic process	metalloaminopeptidase activity	mitochondrion|extracellular region|cell wall-bounded periplasmic space
YGR291C_d	YGR291C	YGR291C	hom	Dubious	3.46977615118327	0.000260446145255384	yes	35	0.000519708124446722	26	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YOL019W_p	YOL019W	YOL019W	hom	Uncharacterized	3.46532779138448	0.000264792784425175	yes	36	0.000595186281047194	26	NA	FT		PLASMA MEMBRANE		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole; YOL019W has a paralog, DCV1, that arose from the whole genome duplication	biological_process	molecular_function	integral to membrane|plasma membrane|fungal-type vacuole
YDR108W	YDR108W	TRS85	hom	Verified	3.41150695060227	0.000323024270972994	yes	37	0.0019973850675158	96	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS|PEROXISOME ORGANIZATION	GOLGI APPARATUS		Subunit of TRAPPIII (transport protein particle), a multimeric guanine nucleotide-exchange factor for Ypt1p, required for membrane expansion during autophagy and the CVT pathway; directs Ypt1p to the PAS; late post-replication meiotic role	meiosis|vesicle organization|piecemeal microautophagy of nucleus|ER to Golgi vesicle-mediated transport|peroxisome degradation|macroautophagy|protein localization to pre-autophagosomal structure|CVT pathway	molecular_function	TRAPP complex|pre-autophagosomal structure
YNL069C	YNL069C	RPL16B	hom	Verified	3.4103340476104	0.000324416783787243	yes	38	0.00106844336250441	36	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L16B; N-terminally acetylated, binds 5.8 S rRNA; transcriptionally regulated by Rap1p; homologous to mammalian ribosomal protein L13A and bacterial L13; RPL16B has a paralog, RPL16A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome|RNA binding	cytosolic large ribosomal subunit
YOR351C	YOR351C	MEK1	hom	Verified	3.40290111310768	0.000333372036211858	yes	39	0.000122497954983042	17	NA	FT	CELL CYCLE|PROTEIN PHOSPHORYLATION	NUCLEUS		Meiosis-specific serine/threonine protein kinase, functions in meiotic checkpoint, promotes recombination between homologous chromosomes by suppressing double strand break repair between sister chromatids	meiosis|meiotic recombination checkpoint|protein phosphorylation	protein serine/threonine kinase activity|protein kinase activity	nucleus
YJL102W	YJL102W	MEF2	hom	Verified	3.37881510640649	0.00036399475449541	yes	40	0.000921994652643918	44	NA	FT	TRANSLATION|NUCLEOTIDE METABOLISM	MITOCHONDRION		Mitochondrial elongation factor involved in translational elongation	translational elongation	translation elongation factor activity	mitochondrion
YOL131W_p	YOL131W	YOL131W	hom	Uncharacterized	3.36425309281314	0.000383755621734807	yes	41	0.00034899926143501	20	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YNL296W_d	YNL296W	YNL296W	hom	Dubious	3.34306956644645	0.000414285627430677	yes	42	0.000712617712853526	42	NA					Dubious open reading frame unlikely to encode a functional protein; deletion adversely affects sporulation; deletion mutant exhibits synthetic phenotype under expression of mutant huntingtin fragment, but gene does not have human ortholog	Unknown	Unknown	Unknown
YIL028W_d	YIL028W	YIL028W	hom	Dubious	3.33768901281985	0.000422391212779422	yes	43	0.000987677195652485	14	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YLR015W	YLR015W	BRE2	hom	Verified	3.33026291785517	0.000433820078818539	yes	44	0.00207433964831723	70	NA	FT	CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS|CHROMOSOME		Subunit of COMPASS (Set1C) complex, which methylates Lys4 of histone H3 and functions in silencing at telomeres; has a C-terminal Sdc1 Dpy-30 Interaction (SDI) domain that mediates binding to Sdc1p; similar to trithorax-group protein ASH2L	histone H3-K4 methylation|telomere maintenance|histone H3-K4 trimethylation|chromatin silencing at telomere	histone methyltransferase activity (H3-K4 specific)	Set1C/COMPASS complex
YGL251C	YGL251C	HFM1	hom	Verified	3.29204027475752	0.000497316833650374	yes	45	0.00134923121660536	29	NA	FT	CELL CYCLE	NUCLEUS		Meiosis specific DNA helicase involved in the conversion of double-stranded breaks to later recombination intermediates and in crossover control; catalyzes the unwinding of Holliday junctions; has ssDNA and dsDNA stimulated ATPase activity	meiosis|synapsis|DNA unwinding involved in replication|reciprocal meiotic recombination	DNA helicase activity	nucleus
YOR263C_d	YOR263C	YOR263C	hom	Dubious	3.28723356366357	0.000505884400323651	yes	46	0.000605967346390536	24	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF DES3/YOR264W	Unknown	Unknown	Unknown
YFR036W	YFR036W	CDC26	hom	Verified	3.27605137859446	0.000526347042315291	yes	47	0.0020346850041349	97	NA	FF|FT	CELL CYCLE|CHROMATIN ORGANIZATION|CELL DIVISION|PROTEOLYSIS	NUCLEUS	UBIQUITIN LIGASE COMPLEX	Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition	chromatin assembly|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination	ubiquitin-protein ligase activity	anaphase-promoting complex
YMR230W	YMR230W	RPS10B	hom	Verified	3.23149394756407	0.000615724659274572	yes	48	0.000874927212897327	21	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10B has a paralog, RPS10A, that arose from the whole genome duplication	cytoplasmic translation|rRNA export from nucleus	structural constituent of ribosome	cytosolic small ribosomal subunit
YLR402W_d	YLR402W	YLR402W	hom	Dubious	3.22290761417155	0.000634482372231334	yes	49	0.0011404511114821	21	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YPL172C	YPL172C	COX10	hom	Verified	3.18502273399373	0.000723713184768785	yes	50	0.0019244586597336	74	NA	FT	COFACTOR METABOLISM	MITOCHONDRION		Heme A:farnesyltransferase, catalyzes the first step in the conversion of protoheme to the heme A prosthetic group required for cytochrome c oxidase activity; human ortholog is associated with mitochondrial disorders	heme a biosynthetic process	protoheme IX farnesyltransferase activity	mitochondrion|integral to membrane
YOR097C_p	YOR097C	YOR097C	hom	Uncharacterized	3.17371059894765	0.00075251836260339	yes	51	0.00185736509226636	54	NA					Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen; YOR097C is not an essential gene	biological_process	molecular_function	cellular_component
YOR120W	YOR120W	GCY1	hom	Verified	3.16800717656012	0.000767438657925274	yes	52	0.00303172879534924	43	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		Glycerol dehydrogenase;involved in an alternative pathway for glycerol catabolism used under microaerobic conditions; also has mRNA binding activity; member of the aldo-keto reductase (AKR) family; protein abundance increases in response to DNA replication stress; GCY1 has a paralog, YPR1, that arose from the whole genome duplication	cellular response to oxidative stress|arabinose catabolic process|D-xylose catabolic process	oxidoreductase activity|mRNA binding|alditol:NADP+ 1-oxidoreductase activity|aldo-keto reductase (NADP) activity	nucleus|cytoplasm
YMR304W	YMR304W	UBP15	hom	Verified	3.07515225633904	0.0010519755870522	no	53	0.0035431890546488	38	NA	FT	PROTEOLYSIS			Ubiquitin-specific protease involved in protein deubiquitination; catalytic activity regulated by an N-terminal TRAF-like domain and and C-terminal sequences; physically interacts with anaphase-promoting complex/cyclosome (APC/C) activator, Cdh1p; forms a complex with AAA peroxins Pex1p and Pex6p	protein deubiquitination	ubiquitin-specific protease activity	peroxisome|cytoplasm
YDL183C	YDL183C	YDL183C	hom	Verified	3.07290498102078	0.0010599298743203	no	54	0.00222593589609078	53	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Mitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system; non-essential gene	potassium ion transport|proton transport	molecular_function	integral to mitochondrial inner membrane
YNL059C	YNL059C	ARP5	hom	Verified	3.0712943374473	0.00106566467694401	no	55	0.00128114872904673	66	NA	FT	CHROMATIN ORGANIZATION	NUCLEUS|CHROMOSOME		Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes	nucleosome mobilization|chromatin remodeling	ATP-dependent 3'-5' DNA helicase activity	nucleus|Ino80 complex
YPR198W	YPR198W	SGE1	hom	Verified	3.06558714107873	0.00108621531071522	no	56	0.00593886698216692	118	NA	FF|FT		PLASMA MEMBRANE		Plasma membrane multidrug transporter of the major facilitator superfamily, acts as an extrusion permease; partial multicopy suppressor of gal11 mutations	response to drug|drug transport	drug transmembrane transporter activity	integral to membrane|integral to plasma membrane
YPR020W	YPR020W	ATP20	hom	Verified	3.05911135172368	0.00110997309983338	no	57	0.000976840663911233	34	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS	MITOCHONDRION		Subunit g of the mitochondrial F1F0 ATP synthase; reversibly phosphorylated on two residues; unphosphorylated form is required for dimerization of the ATP synthase complex	protein oligomerization|cristae formation|protein complex assembly|ATP synthesis coupled proton transport	structural molecule activity|proton-transporting ATPase activity, rotational mechanism	mitochondrion|mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
YDL168W	YDL168W	SFA1	hom	Verified	3.03506806813536	0.00120240703014094	no	58	0.0036425963830038	44	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS	MITOCHONDRION		Bifunctional alcohol dehydrogenase and formaldehyde dehydrogenase; formaldehyde dehydrogenase activity is glutathione-dependent; functions in formaldehyde detoxification and formation of long chain and complex alcohols, regulated by Hog1p-Sko1p; protein abundance increases in response to DNA replication stress	furaldehyde metabolic process|formaldehyde catabolic process|amino acid catabolic process to alcohol via Ehrlich pathway	S-(hydroxymethyl)glutathione dehydrogenase activity|hydroxymethylfurfural reductase (NADH) activity|alcohol dehydrogenase (NAD) activity	mitochondrion|cytoplasm
YNL053W	YNL053W	MSG5	hom	Verified	3.02326879228394	0.00125030013974912	no	59	0.00176468555331146	39	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|SIGNALING|CELL WALL ORG/BIOGENESIS|PROTEIN PHOSPHORYLATION	NUCLEUS		Dual-specificity protein phosphatase; exists in 2 isoforms; required for maintenance of a low level of signaling through the cell integrity pathway, adaptive response to pheromone; regulates and is regulated by Slt2p; dephosphorylates Fus3p	adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion|regulation of fungal-type cell wall organization|inactivation of MAPK activity involved in cell wall biogenesis|regulation of MAPK export from nucleus|protein dephosphorylation|inactivation of MAPK activity involved in conjugation with cellular fusion	protein tyrosine/serine/threonine phosphatase activity	nucleus|cytoplasm
YJR010C-A	YJR010C-A	SPC1	hom	Verified	3.01442204359706	0.00128734684373485	no	60	0.00136769002711549	45	NA	FT	PROTEIN LOCALIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Subunit of the signal peptidase complex (SPC); SPC cleaves the signal sequence from proteins targeted to the endoplasmic reticulum (ER); homolog of the SPC12 subunit of mammalian signal peptidase complex; protein abundance increases in response to DNA replication stress	signal peptide processing|protein targeting to ER	molecular_function	signal peptidase complex
YPR027C_p	YPR027C	YPR027C	hom	Uncharacterized	3.00204457533284	0.00134086452284741	no	61	0.00334891472920452	70	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YHR064C	YHR064C	SSZ1	hom	Verified	2.98641100966088	0.00141136490089993	no	62	0.00125844573567071	63	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION			Hsp70 protein that interacts with Zuo1p (a DnaJ homolog) to form a ribosome-associated complex that binds the ribosome via the Zuo1p subunit; also involved in pleiotropic drug resistance via sequential activation of PDR1 and PDR5; binds ATP	cytoplasmic translation|regulation of translational fidelity|rRNA processing	unfolded protein binding	polysome|cytoplasm
YER087C-A_d	YER087C-A	YER087C-A	hom	Dubious	2.98584448642637	0.00141398208822909	no	63	0.000927253786194318	32	NA					Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; overlaps the uncharacterized gene YER087W, a putative tRNA synthetase	Unknown	Unknown	Unknown
YCL064C	YCL064C	CHA1	hom	Verified	2.97267395981396	0.00147608931843742	no	64	0.00141831719529196	33	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		Catabolic L-serine (L-threonine) deaminase, catalyzes the degradation of both L-serine and L-threonine; required to use serine or threonine as the sole nitrogen source, transcriptionally induced by serine and threonine	threonine catabolic process|L-serine catabolic process	L-threonine ammonia-lyase activity|L-serine ammonia-lyase activity	mitochondrial nucleoid|mitochondrion
YNL217W_p	YNL217W	YNL217W	hom	Uncharacterized	2.97252602723974	0.00147680083449258	no	65	0.000746759782856719	27	NA					Putative protein of unknown function; weak sequence similarity to bis (5'-nucleotidyl)-tetraphosphatases; (GFP)-fusion protein localizes to the vacuole; null mutant is highly sensitive to azaserine and resistant to sodium-O-vandate	biological_process	phosphatase activity	fungal-type vacuole
YMR254C_d	YMR254C	YMR254C	hom	Dubious	2.94986526896137	0.00158956265842742	no	66	0.00116311633768863	26	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YCR025C_d	YCR025C	YCR025C	hom	Dubious	2.92460804023266	0.00172445166770311	no	67	0.00196180065878282	77	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR025C is not an essential gene	Unknown	Unknown	Unknown
YLR451W	YLR451W	LEU3	hom	Verified	2.92460568078804	0.00172446474111269	no	68	0.0014540786523734	48	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Zinc-knuckle transcription factor, repressor and activator; regulates genes involved in branched chain amino acid biosynthesis and ammonia assimilation; acts as a repressor in leucine-replete conditions and as an activator in the presence of alpha-isopropylmalate, an intermediate in leucine biosynthesis that accumulates during leucine starvation	negative regulation of transcription from RNA polymerase II promoter|Unknown|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YNL025C	YNL025C	SSN8	hom	Verified	2.91671250341931	0.00176870832170603	no	69	0.00359005357788231	88	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Cyclin-like component of the RNA polymerase II holoenzyme, involved in phosphorylation of the RNA polymerase II C-terminal domain; involved in glucose repression and telomere maintenance	positive regulation of transcription from RNA polymerase II promoter during meiosis|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription by galactose|positive regulation of transcription from RNA polymerase II promoter	cyclin-dependent protein kinase regulator activity	mediator complex
YIR033W	YIR033W	MGA2	hom	Verified	2.90327685267268	0.00184640014988047	no	70	0.00211678118185276	27	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|LIPID METABOLISM|GENE SILENCING	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM		ER membrane protein involved in regulation of OLE1 transcription, acts with homolog Spt23p; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting	positive regulation of transcription from RNA polymerase II promoter in response to hypoxia|cellular response to cold|positive regulation of unsaturated fatty acid biosynthetic process by positive regulation of transcription from RNA polymerase II promoter|mRNA stabilization|positive regulation of transcription from RNA polymerase II promoter in response to cobalt ion|positive regulation of transcription from RNA polymerase II promoter|chromatin silencing at silent mating-type cassette	molecular_function	integral to endoplasmic reticulum membrane|nucleus
YLL014W	YLL014W	EMC6	hom	Verified	2.90133933119854	0.00185785635302064	no	71	0.0036109891395984	69	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm F33D4.7/EMC-6, fly CG11781, human TMEM93	protein folding in endoplasmic reticulum	molecular_function	ER membrane protein complex|integral to membrane|endoplasmic reticulum
YGR270W	YGR270W	YTA7	hom	Verified	2.89273983121832	0.00190948746403255	no	72	0.00835657747297462	82	NA	FT	TRANSCRIPTION FROM RNA POL II|GENE SILENCING	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM		Protein that localizes to chromatin and has a role in regulation of histone gene expression; has a bromodomain-like region that interacts with the N-terminal tail of histone H3, and an ATPase domain; potentially phosphorylated by Cdc28p	negative regulation of transcription from RNA polymerase II promoter|negative regulation of chromatin silencing|positive regulation of transcription from RNA polymerase II promoter	chromatin binding|histone binding	extrinsic to endoplasmic reticulum membrane|nucleus
YBR114W	YBR114W	RAD16	hom	Verified	2.89082164146692	0.00192118059841263	no	73	0.0021663362838684	54	NA	FT	RESPONSE TO DNA DAMAGE|PROTEOLYSIS	NUCLEUS	UBIQUITIN LIGASE COMPLEX	Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad7p) during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex	nucleotide-excision repair, DNA damage recognition|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	ubiquitin-protein ligase activity|damaged DNA binding|DNA-dependent ATPase activity	nucleotide-excision repair factor 4 complex|Cul3-RING ubiquitin ligase complex
YLR251W	YLR251W	SYM1	hom	Verified	2.88233417605652	0.00197370422821238	no	74	0.00117059323677493	33	NA	FT		MITOCHONDRION		Protein required for ethanol metabolism; induced by heat shock and localized to the inner mitochondrial membrane; homologous to mammalian peroxisomal membrane protein Mpv17	ethanol metabolic process	molecular_function	mitochondrion|integral to membrane|mitochondrial inner membrane
YJL048C	YJL048C	UBX6	hom	Verified	2.86476330028889	0.00208660526678838	no	75	0.00120380224970493	41	NA	FT	PROTEOLYSIS	NUCLEUS		UBX (ubiquitin regulatory X) domain-containing protein; interacts with Cdc48p, transcription is repressed when cells are grown in media containing inositol and choline; UBX6 has a paralog, UBX7, that arose from the whole genome duplication	sporulation resulting in formation of a cellular spore|ubiquitin-dependent protein catabolic process	molecular_function	nucleus
YCR044C	YCR044C	PER1	hom	Verified	2.84437614590186	0.00222492409969048	no	76	0.0229918835428135	150	NA	FF|FT	LIPID METABOLISM|ION HOMEOSTASIS|ION HOMEOSTASIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein of the endoplasmic reticulum, required for GPI-phospholipase A2 activity that remodels the GPI anchor as a prerequisite for association of GPI-anchored proteins with lipid rafts; functionally complemented by human ortholog PERLD1	GPI anchor biosynthetic process|cellular manganese ion homeostasis	molecular_function	fungal-type vacuole membrane|integral to membrane|endoplasmic reticulum
YKR097W	YKR097W	PCK1	hom	Verified	2.82829117668949	0.00233986103803715	no	77	0.0022052988649071	82	NA	FT	CARBOHYDRATE METABOLISM			Phosphoenolpyruvate carboxykinase, key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol	gluconeogenesis	phosphoenolpyruvate carboxykinase (ATP) activity	cytosol
YHR048W_p	YHR048W	YHK8	hom	Uncharacterized	2.79486757547843	0.00259604892123887	no	78	0.00349513373401382	45	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Presumed antiporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; expression of gene is up-regulated in cells exhibiting reduced susceptibility to azoles	drug transport	molecular_function	integral to membrane
YML071C	YML071C	COG8	hom	Verified	2.78937908477525	0.00264046058936833	no	79	0.0726820605171635	420	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments	intra-Golgi vesicle-mediated transport|CVT pathway	molecular_function	Golgi transport complex
YDR538W	YDR538W	PAD1	hom	Verified	2.78666822479172	0.00266264848262917	no	80	0.00213061234674471	73	NA	FT	KETONE METABOLISM	MITOCHONDRION		Phenylacrylic acid decarboxylase, confers resistance to cinnamic acid, decarboxylates aromatic carboxylic acids to the corresponding vinyl derivatives; also has mRNA binding activity; homolog of E. coli UbiX	cinnamic acid catabolic process|aromatic compound catabolic process	mRNA binding|carboxy-lyase activity	mitochondrion
YLL049W	YLL049W	LDB18	hom	Verified	2.7848237837385	0.00267784100843047	no	81	0.00144361067219385	45	NA	FT	CELL CYCLE|CYTOSKELETON ORGANIZATION	CYTOSKELETON		Component of the dynactin complex, which is required for dynein activity; null mutant exhibits defects in nuclear migration and spindle orientation and has reduced affinity for alcian blue dye; has homology to mammalian dynactin subunit p24	establishment of mitotic spindle orientation	molecular_function	dynactin complex|cell cortex|spindle pole body|astral microtubule
YFR035C_p	YFR035C	YFR035C	hom	Uncharacterized	2.77330168984347	0.00277453250750148	no	82	0.00242762307225728	66	NA					Putative protein of unknown function, deletion mutant exhibits synthetic phenotype with alpha-synuclein	biological_process	molecular_function	cellular_component
YLR358C_p	YLR358C	YLR358C	hom	Uncharacterized	2.75159481762762	0.00296529242328578	no	83	0.00262668452557689	83	NA					Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps ORF RSC2/YLR357W	biological_process	molecular_function	cellular_component
YPL261C_d	YPL261C	YPL261C	hom	Dubious	2.75084872974234	0.00297205425892258	no	84	0.00236546925929494	67	NA					Dubious open reading frame unlikely to encode a protein; partially overlaps the uncharacterized ORF YPL260W	Unknown	Unknown	Unknown
YOL112W	YOL112W	MSB4	hom	Verified	2.73665157908541	0.0031033996467132	no	85	0.00336404078062498	58	NA	FT	SIGNALING|NUCLEOTIDE METABOLISM|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH		GTPase-activating protein of the Ras superfamily that acts primarily on Sec4p, localizes to the bud site and bud tip, has similarity to Msb3p; msb3 msb4 double mutation causes defects in secretion and actin organization	actin filament organization	Rab GTPase activator activity	incipient cellular bud site|polarisome|cellular bud tip
YOL124C	YOL124C	TRM11	hom	Verified	2.73438306417507	0.00312486448183311	no	86	0.00253167498619901	66	NA	FT	RNA PROCESSING			Catalytic subunit of an adoMet-dependent tRNA methyltransferase complex (Trm11p-Trm112p), required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs; contains a THUMP domain and a methyltransferase domain	tRNA methylation	S-adenosylmethionine-dependent methyltransferase activity|RNA binding|tRNA (guanine-N2-)-methyltransferase activity	cytoplasm|tRNA (m2G10) methyltransferase complex
YBL057C	YBL057C	PTH2	hom	Verified	2.7194565688133	0.00326946407497053	no	87	0.00475079093819228	62	NA	FT	PROTEOLYSIS	MITOCHONDRION		One of two (see also PTH1) mitochondrially-localized peptidyl-tRNA hydrolases; negatively regulates the ubiquitin-proteasome pathway via interactions with ubiquitin-like ubiquitin-associated proteins; dispensable for cell growth	negative regulation of proteasomal ubiquitin-dependent protein catabolic process	aminoacyl-tRNA hydrolase activity	mitochondrial outer membrane|mitochondrion|cytoplasm
YDR017C	YDR017C	KCS1	hom	Verified	2.69522134222165	0.00351709433578929	no	88	0.00524743135197734	96	NA					Inositol hexakisphosphate (IP6) and inositol heptakisphosphate (IP7) kinase; generation of high energy inositol pyrophosphates by Kcs1p is required for many processes such as vacuolar biogenesis, stress response and telomere maintenance	inositol phosphate biosynthetic process	inositol heptakisphosphate kinase activity|inositol hexakisphosphate kinase activity|inositol-1,3,4,5,6-pentakisphosphate kinase activity|inositol heptakisphosphate 5-kinase activity	cytoplasm
YAR023C_p	YAR023C	YAR023C	hom	Uncharacterized	2.68644231385166	0.00361087086097406	no	89	0.00329736514593338	59	NA					Putative integral membrane protein, member of DUP240 gene family	biological_process	molecular_function	cellular_component
YML063W	YML063W	RPS1B	hom	Verified	2.67936172593132	0.00368813307491987	no	90	0.00562506250305118	69	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Ribosomal protein 10 (rp10) of the small (40S) subunit; homologous to mammalian ribosomal protein S3A, no bacterial homolog; RPS1B has a paralog, RPS1A, that arose from the whole genome duplication	cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome	cytosolic small ribosomal subunit|90S preribosome
YCL034W	YCL034W	LSB5	hom	Verified	2.67556610065708	0.00373015800876967	no	91	0.00730580548521164	38	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION	CYTOSKELETON		Protein of unknown function; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; may mediate disassembly of the Pan1 complex from the endocytic coat	endocytosis|actin filament organization|actin cortical patch localization|actin cytoskeleton organization	molecular_function	cell cortex|cytoplasm|actin cortical patch
YJR110W	YJR110W	YMR1	hom	Verified	2.66760632643385	0.00381968562466343	no	92	0.00384273742660724	39	NA	FT	LIPID METABOLISM			Phosphatidylinositol 3-phosphate (PI3P) phosphatase; involved in various protein sorting pathways, including CVT targeting and endosome to vacuole transport; has similarity to the conserved myotubularin dual specificity phosphatase family	phosphatidylinositol dephosphorylation	mRNA binding|phosphatidylinositol-3-phosphatase activity	cytoplasm
YDL167C	YDL167C	NRP1	hom	Verified	2.6670322224787	0.00382621672857474	no	93	0.00529703760555489	85	NA					Putative RNA binding protein of unknown function; localizes to stress granules induced by glucose deprivation; predicted to be involved in ribosome biogenesis	biological_process	molecular_function	cytoplasmic stress granule|cytoplasm
YAL023C	YAL023C	PMT2	hom	Verified	2.6632923264136	0.00386900795745804	no	94	0.0095541883025587	97	NA	FT	PROTEIN LOCALIZATION|CARBOHYDRATE METABOLISM|PROTEOLYSIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein O-mannosyltransferase of the ER membrane; transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; involved in ER quality control; acts in a complex with Pmt1p, can instead interact with Pmt5p; antifungal drug target; PMT2 has a paralog, PMT3, that arose from the whole genome duplication	ER-associated misfolded protein catabolic process|protein O-linked glycosylation|Unknown|protein exit from endoplasmic reticulum|protein O-linked mannosylation	dolichyl-phosphate-mannose-protein mannosyltransferase activity	integral to membrane|dolichyl-phosphate-mannose-protein mannosyltransferase complex
YNL050C_p	YNL050C	YNL050C	hom	Uncharacterized	2.66142373321793	0.00389054831645285	no	95	0.00384059242557853	46	NA					Putative protein of unknown function; YNL050c is not an essential gene	biological_process	molecular_function	cellular_component
YGL041C_d	YGL041C	YGL041C	hom	Dubious	2.65546500353653	0.00395995754325677	no	96	0.00598359889697531	66	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YPL006W	YPL006W	NCR1	hom	Verified	2.63461449869809	0.00421164444884021	no	97	0.00448175671742669	57	NA	FT	LIPID METABOLISM			Vacuolar membrane protein that transits through the biosynthetic vacuolar protein sorting pathway, involved in sphingolipid metabolism; glycoprotein and functional orthologue of human Niemann Pick C1 (NPC1) protein	sphingolipid metabolic process	sphingolipid transporter activity	fungal-type vacuole membrane|integral to membrane
YNL211C_p	YNL211C	YNL211C	hom	Uncharacterized	2.62035221002214	0.00439194970662241	no	98	0.00350265464128012	70	NA	FT		MITOCHONDRION		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL211C is not an essential gene	biological_process	molecular_function	mitochondrion
YOR071C	YOR071C	NRT1	hom	Verified	2.61003425398186	0.0045266578462474	no	99	0.00310581705736133	47	NA	FT		PLASMA MEMBRANE		High-affinity nicotinamide riboside transporter; also transports thiamine with low affinity; shares sequence similarity with Thi7p and Thi72p; proposed to be involved in 5-fluorocytosine sensitivity	thiamine transport|nicotinamide riboside transport	nicotinamide riboside transporter activity	integral to membrane|plasma membrane
YOR345C_d	YOR345C	YOR345C	hom	Dubious	2.60689044831728	0.00456842938758525	no	100	0.00439474616410869	44	NA					Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene REV1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2	Unknown	Unknown	Unknown
YDR090C_p	YDR090C	YDR090C	hom	Uncharacterized	2.60686422862211	0.00456877920903099	no	101	0.00638843588410331	65	NA	FT		PLASMA MEMBRANE		Putative protein of unknown function	biological_process	molecular_function	integral to membrane
YOR379C_d	YOR379C	YOR379C	hom	Dubious	2.57298488037802	0.00504128061422186	no	102	0.00439356566370054	54	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR378W	Unknown	Unknown	Unknown
YEL016C	YEL016C	NPP2	hom	Verified	2.5509590570866	0.00537134725367799	no	103	0.00607977964374506	58	NA	FT	NUCLEOTIDE METABOLISM			Nucleotide pyrophosphatase/phosphodiesterase; mediates extracellular nucleotide phosphate hydrolysis along with Npp1p and Pho5p; activity and expression enhanced during conditions of phosphate starvation; NPP2 has a paralog, NPP1, that arose from the whole genome duplication	nucleoside triphosphate metabolic process	nucleotide diphosphatase activity|nucleoside-triphosphate diphosphatase activity|nucleoside-triphosphatase activity|phosphodiesterase I activity	cellular_component
YKR092C	YKR092C	SRP40	hom	Verified	2.5434527087495	0.00548814570756816	no	104	0.00423775060913183	84	NA	FT		NUCLEUS		Nucleolar, serine-rich protein with a role in preribosome assembly or transport; may function as a chaperone of small nucleolar ribonucleoprotein particles (snoRNPs); immunologically and structurally to rat Nopp140	nucleocytoplasmic transport	molecular_function	nucleolus
YJR024C	YJR024C	MDE1	hom	Verified	2.54275454239293	0.00549912302355097	no	105	0.00369274036818093	47	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			5'-methylthioribulose-1-phosphate dehydratase; acts in the methionine salvage pathway; potential Smt3p sumoylation substrate; expression downregulated by caspofungin and deletion mutant is caspofungin resistant	L-methionine salvage from methylthioadenosine	methylthioribulose 1-phosphate dehydratase activity	cytoplasm
YHR034C	YHR034C	PIH1	hom	Verified	2.53015241577068	0.00570064937596917	no	106	0.0119811001288942	105	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Component of the conserved R2TP complex (Rvb1-Rvb2-Tah1-Pih1); R2TP complex interacts with Hsp90 (Hsp82p and Hsc82p) to mediate assembly large protein complexes such as box C/D snoRNPs and RNA polymerase II	protein folding|rRNA processing|regulation of cell size|box C/D snoRNP assembly	molecular_function	R2TP complex|nucleus|small nucleolar ribonucleoprotein complex|cytoplasm
YLR452C	YLR452C	SST2	hom	Verified	2.51741459896377	0.00591098126766169	no	107	0.00496518957820299	55	NA	FT	SIGNALING	PLASMA MEMBRANE		GTPase-activating protein for Gpa1p, regulates desensitization to alpha factor pheromone; also required to prevent receptor-independent signaling of the mating pathway; member of the RGS (regulator of G-protein signaling) family	adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion|signal transduction	GTPase activator activity	plasma membrane
YNR066C_p	YNR066C	YNR066C	hom	Uncharacterized	2.51741292005219	0.00591100943819295	no	108	0.00847404669626525	109	NA					Putative membrane-localized protein of unknown function	biological_process	molecular_function	integral to membrane|membrane
YGL090W	YGL090W	LIF1	hom	Verified	2.51581271169162	0.00593791360376054	no	109	0.00643302903590373	100	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Component of the DNA ligase IV complex that mediates nonhomologous end joining in DNA double-strand break repair; physically interacts with Dnl4p and Nej1p; homologous to mammalian XRCC4 protein	double-strand break repair via nonhomologous end joining	chromatin binding	DNA ligase IV complex|nuclear chromatin|nucleus
YEL059C-A	YEL059C-A	SOM1	hom	Verified	2.50953006059612	0.0060445962791495	no	110	0.00392163994543052	66	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs	proteolysis|mitochondrial respiratory chain complex assembly	endopeptidase activity	mitochondrial inner membrane peptidase complex|mitochondrial inner membrane
YBR084C-A	YBR084C-A	RPL19A	hom	Verified	2.50411459559364	0.00613791333151274	no	111	0.00768594783229751	99	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L19A; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal; homologous to mammalian ribosomal protein L19, no bacterial homolog; RPL19A has a paralog, RPL19B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YPR040W	YPR040W	TIP41	hom	Verified	2.50337169894922	0.00615081367120142	no	112	0.00939251003872894	123	NA	FT	SIGNALING	NUCLEUS		Protein that interacts with Tap42p, which regulates PP2A; component of the TOR (target of rapamycin) signaling pathway; protein abundance increases in response to DNA replication stress	signal transduction	molecular_function	nucleus|cytoplasm
YGR249W	YGR249W	MGA1	hom	Verified	2.50001927484411	0.00620932747865659	no	113	0.00724165848361926	86	NA	FT		NUCLEUS		Protein similar to heat shock transcription factor; multicopy suppressor of pseudohyphal growth defects of ammonium permease mutants	filamentous growth	sequence-specific DNA binding|DNA binding|sequence-specific DNA binding transcription factor activity	nucleus
YDL109C_p	YDL109C	YDL109C	hom	Uncharacterized	2.49364843319044	0.00632188535422261	no	114	0.00696660602575057	42	NA	FT	LIPID METABOLISM			Putative lipase; involved in lipid metabolism; not an essential gene; YDL109C has a paralog, ROG1, that arose from the whole genome duplication	cellular lipid metabolic process	molecular_function	cellular_component
YMR075C-A_d	YMR075C-A	YMR075C-A	hom	Dubious	2.47597062042774	0.00664372559089132	no	115	0.00704424653107897	69	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF RCO1/YMR075W	Unknown	Unknown	Unknown
YPR062W	YPR062W	FCY1	hom	Verified	2.47230248784212	0.00671229362650783	no	116	0.010891839351358	122	NA	FT		NUCLEUS		Cytosine deaminase, zinc metalloenzyme that catalyzes the hydrolytic deamination of cytosine to uracil; of biomedical interest because it also catalyzes the deamination of 5-fluorocytosine (5FC) to form anticancer drug 5-fluorouracil (5FU)	cytosine metabolic process|pyrimidine-containing compound salvage|cytidine metabolic process	cytosine deaminase activity	nucleus|cytoplasm
YOL090W	YOL090W	MSH2	hom	Verified	2.46877126940223	0.00677889239868321	no	117	0.00878762490326922	91	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|GENE SILENCING	NUCLEUS|CHROMOSOME		Protein that forms heterodimers with Msh3p and Msh6p that bind to DNA mismatches to initiate the mismatch repair process; contains a Walker ATP-binding motif required for repair activity and involved in interstrand cross-link repair; Msh2p-Msh6p binds to and hydrolyzes ATP	mismatch repair|mitotic recombination|meiotic gene conversion|meiotic mismatch repair|removal of nonhomologous ends|DNA recombination|chromatin silencing at silent mating-type cassette	loop DNA binding|single base insertion or deletion binding|ATP binding|Y-form DNA binding|double-strand/single-strand DNA junction binding|DNA insertion or deletion binding|guanine/thymine mispair binding|four-way junction DNA binding|ATPase activity	MutSbeta complex|nuclear chromosome|MutSalpha complex|nucleus
YML061C	YML061C	PIF1	hom	Verified	2.45088293651526	0.00712531454364223	no	118	0.0132504999178851	147	NA	FT	RESPONSE TO DNA DAMAGE|MITOCHONDRION ORGANIZATION	NUCLEUS|MITOCHONDRION		DNA helicase; exists in a nuclear form that acts as a catalytic inhibitor of telomerase; and as a mitochondrial form involved in repair and recombination of mitochondrial DNA; mutations affect zinc and iron homeostasis; regulated by Rad53p-dependent phosphorylation in rho0 cells	chromosome organization|negative regulation of telomere maintenance via telomerase|telomere maintenance|mitochondrial genome maintenance|DNA recombination	DNA helicase activity|telomerase inhibitor activity	mitochondrion|nucleus|mitochondrial membrane
YHR139C-A_d	YHR139C-A	YHR139C-A	hom	Dubious	2.45042797683315	0.00713432525689288	no	119	0.00517393777495296	83	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDR069C	YDR069C	DOA4	hom	Verified	2.44539265145485	0.00723472580978266	no	120	0.0117277420778044	139	NA	FT	VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|PROTEOLYSIS	MITOCHONDRION		Ubiquitin isopeptidase, required for recycling ubiquitin from proteasome-bound ubiquitinated intermediates, acts at the late endosome/prevacuolar compartment to recover ubiquitin from ubiquitinated membrane proteins en route to the vacuole	protein deubiquitination|endocytosis|regulation of DNA replication|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|free ubiquitin chain depolymerization|ubiquitin homeostasis|ubiquitin-dependent protein catabolic process	endopeptidase activity|ubiquitin-specific protease activity|ubiquitin thiolesterase activity	endosome|proteasome complex|mitochondrion
YLR288C	YLR288C	MEC3	hom	Verified	2.44315467518755	0.00727974788449719	no	121	0.00332892065282844	44	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|GENE SILENCING	NUCLEUS|CHROMOSOME		DNA damage and meiotic pachytene checkpoint protein; subunit of a heterotrimeric complex (Rad17p-Mec3p-Ddc1p) that forms a sliding clamp, loaded onto partial duplex DNA by a clamp loader complex; homolog of human and S. pombe Hus1	telomere maintenance via recombination|DNA damage checkpoint|DNA metabolic process|chromatin silencing at telomere	DNA binding	nucleus|checkpoint clamp complex
YIR018W	YIR018W	YAP5	hom	Verified	2.44066752663507	0.00733007228239656	no	122	0.00490235686240472	77	NA	FT	TRANSCRIPTION FROM RNA POL II|GENE SILENCING	NUCLEUS|CHROMOSOME		Basic leucine zipper (bZIP) iron-sensing transcription factor; YAP5 has a paralog, YAP7, that arose from the whole genome duplication	negative regulation of chromatin silencing at telomere|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter in response to iron|positive regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding RNA polymerase II transcription factor activity	nuclear chromatin|nucleus
YDL074C	YDL074C	BRE1	hom	Verified	2.43894738580208	0.00736505636977525	no	123	0.0302230687780633	156	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING	NUCLEUS|CHROMOSOME		E3 ubiquitin ligase, forms heterodimer with Rad6p to monoubiquinate histone H2B-K123, which is required for the subsequent methylation of histone H3-K4 and H3-K79; required for DSBR, transcription, silencing, and checkpoint control	mitotic cell cycle G1/S transition DNA damage checkpoint|intra-S DNA damage checkpoint|meiotic DNA double-strand break formation|histone monoubiquitination|double-strand break repair via homologous recombination|transcription from RNA polymerase II promoter|chromatin silencing at telomere	ubiquitin-protein ligase activity	nuclear chromatin
YBL028C	YBL028C	YBL028C	hom	Verified	2.4353271938424	0.00743916466040858	no	124	0.0122066037352352	62	NA	FT		NUCLEUS		Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis	biological_process	molecular_function	ribosome|nucleolus|nucleus|preribosome, large subunit precursor
YER131W	YER131W	RPS26B	hom	Verified	2.43412086560206	0.00746400472179036	no	125	0.00830734050562054	81	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S26, no bacterial homolog; RPS26B has a paralog, RPS26A, that arose from the whole genome duplication	cytoplasmic translation|rRNA export from nucleus	structural constituent of ribosome	cytosolic small ribosomal subunit
YER111C	YER111C	SWI4	hom	Verified	2.43090415856496	0.00753059898807273	no	126	0.00909975492944114	129	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE	NUCLEUS|CHROMOSOME		DNA binding component of the SBF complex (Swi4p-Swi6p); a transcriptional activator that in concert with MBF (Mbp1-Swi6p) regulates late G1-specific transcription of targets including cyclins and genes required for DNA synthesis and repair; acetylation at two sites, K1016 and K1066, regulates interaction with Swi6p	positive regulation of transcription from RNA polymerase II promoter in response to heat stress|positive regulation of transcription involved in G1/S phase of mitotic cell cycle	sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	SBF transcription complex|nuclear chromatin
YLR170C	YLR170C	APS1	hom	Verified	2.43043984309033	0.00754025463141277	no	127	0.0103073560119827	114	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Small subunit of the clathrin-associated adaptor complex AP-1, which is involved in protein sorting at the trans-Golgi network; homolog of the sigma subunit of the mammalian clathrin AP-1 complex	Golgi to vacuole transport|vesicle-mediated transport	clathrin binding	AP-1 adaptor complex
YPR076W_d	YPR076W	YPR076W	hom	Dubious	2.42868205647799	0.00757690742260913	no	128	0.0109036841903159	103	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YHR126C_p	YHR126C	ANS1	hom	Uncharacterized	2.42121297270819	0.00773440580736411	no	129	0.00703931701930856	77	NA	FT		PLASMA MEMBRANE		Putative GPI protein; transcription dependent upon Azf1p	biological_process	molecular_function	cellular_component
YHR136C	YHR136C	SPL2	hom	Verified	2.41824386194162	0.00779781052219628	no	130	0.00884232905095963	82	NA					Protein with similarity to cyclin-dependent kinase inhibitors; downregulates low-affinity phosphate transport during phosphate limitation; overproduction suppresses a plc1 null mutation; GFP-fusion protein localizes to the cytoplasm	response to temperature stimulus	enzyme inhibitor activity	cytoplasm
YGL211W	YGL211W	NCS6	hom	Verified	2.41653992551342	0.00783440387725461	no	131	0.00937554147370481	96	NA	FT	RNA PROCESSING	MITOCHONDRION		Protein required for thiolation of the uridine at the wobble position of Gln, Lys, and Glu tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae	tRNA wobble position uridine thiolation|protein urmylation|tRNA wobble uridine modification	tRNA binding	cytosol|mitochondrion
YGR130C	YGR130C	YGR130C	hom	Verified	2.41518913280345	0.00786352046433475	no	132	0.0136898018904768	118	NA					Component of the eisosome with unknown function; GFP-fusion protein localizes to the cytoplasm; specifically phosphorylated in vitro by mammalian diphosphoinositol pentakisphosphate (IP7)	biological_process	molecular_function	eisosome|membrane raft|cytoplasm
YBL048W_d	YBL048W	RRT1	hom	Dubious	2.40968538432475	0.00798314111218319	no	133	0.0134945863080552	121	NA					Identified in a screen for mutants with increased levels of rDNA transcription; dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data	Unknown	Unknown	Unknown
YGL119W	YGL119W	COQ8	hom	Verified	2.40739135999814	0.00803347088850435	no	134	0.0118452951481353	105	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication	ubiquinone biosynthetic process|aerobic respiration	molecular_function	mitochondrion|extrinsic to mitochondrial inner membrane|mitochondrial matrix
YLR382C	YLR382C	NAM2	hom	Verified	2.40371199634325	0.00811477688935176	no	135	0.0124862385675517	112	NA	FT	KETONE METABOLISM|RNA PROCESSING|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial leucyl-tRNA synthetase, also has a direct role in splicing of several mitochondrial group I introns; indirectly required for mitochondrial genome maintenance	Group I intron splicing|leucyl-tRNA aminoacylation|mitochondrial translation	mRNA binding|leucine-tRNA ligase activity	mitochondrion
YLR406C	YLR406C	RPL31B	hom	Verified	2.4026024369565	0.00813943726361118	no	136	0.0187705630922961	101	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L31B; associates with karyopherin Sxm1p; loss of both Rpl31p and Rpl39p confers lethality; homologous to mammalian ribosomal protein L31, no bacterial homolog; RPL31B has a paralog, RPL31A, that arose from the whole genome duplication	cytoplasmic translation|regulation of translational fidelity	structural constituent of ribosome	cytosolic large ribosomal subunit
YKR007W	YKR007W	MEH1	hom	Verified	2.39167281355633	0.0083858931008551	no	137	0.0118530883452445	173	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS			Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; loss results in a defect in vacuolar acidification	microautophagy|vacuolar acidification	molecular_function	fungal-type vacuole membrane|EGO complex|late endosome membrane
YOL129W	YOL129W	VPS68	hom	Verified	2.38781931432643	0.00847433609069652	no	138	0.0115826446947759	131	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	MITOCHONDRION		Vacuolar membrane protein of unknown function involved in vacuolar protein sorting; also detected in the mitochondria	late endosome to vacuole transport via multivesicular body sorting pathway|protein targeting to vacuole	molecular_function	Vps55/Vps68 complex|mitochondrion|fungal-type vacuole membrane|integral to membrane
YOR023C	YOR023C	AHC1	hom	Verified	2.38711796611165	0.00849052073342454	no	139	0.00582805587022226	78	NA	FT	CHROMATIN ORGANIZATION	NUCLEUS	HISTONE ACETYLTRANSFERASE	Subunit of the Ada histone acetyltransferase complex, required for structural integrity of the complex	histone acetylation	histone acetyltransferase activity	Ada2/Gcn5/Ada3 transcription activator complex
YMR041C	YMR041C	ARA2	hom	Verified	2.37927345598511	0.00867340102345368	no	140	0.00758117459578811	50	NA	FT	OXIDATION-REDUCTION PROCESS			NAD-dependent arabinose dehydrogenase, involved in biosynthesis of dehydro-D-arabinono-1,4-lactone; similar to plant L-galactose dehydrogenase	dehydro-D-arabinono-1,4-lactone biosynthetic process	D-arabinose 1-dehydrogenase [NAD(P)+] activity	cellular_component
YLR151C	YLR151C	PCD1	hom	Verified	2.36398678626994	0.0090397287081284	no	141	0.00818663125151357	94	NA	FT	NUCLEOTIDE METABOLISM			Peroxisomal pyrophosphatase with specificity for coenzyme A and CoA derivatives, may function to remove potentially toxic oxidized CoA disulfide from peroxisomes to maintain the capacity for beta-oxidation of fatty acids; nudix hydrolase family member	biological_process	pyrophosphatase activity	peroxisome
YDL073W_p	YDL073W	YDL073W	hom	Uncharacterized	2.36375212859855	0.00904545604014719	no	142	0.0170899967569089	112	NA					Putative protein of unknown function; YDL073W is not an essential gene	biological_process	molecular_function	cellular_component
YDR132C	YDR132C	YDR132C	hom	Verified	2.36214453595058	0.00908477837361634	no	143	0.0063893460136751	51	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	NUCLEUS|PLASMA MEMBRANE		Protein of unknown function; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress; YDR132C has a paralog, YLR108C, that arose from the whole genome duplication	biological_process	molecular_function	nucleus|cytoplasm
YHR203C	YHR203C	RPS4B	hom	Verified	2.36195864106041	0.00908933507521151	no	144	0.0176297802672358	118	NA	FT	TRANSLATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S4, no bacterial homolog; RPS4B has a paralog, RPS4A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic small ribosomal subunit|90S preribosome
YCL026C-B	YCL026C-B	HBN1	hom	Verified	2.36133798634199	0.00910456321593793	no	145	0.0122376613020778	114	NA	FT	OXIDATION-REDUCTION PROCESS	NUCLEUS		Protein of unknown function; similar to bacterial nitroreductases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; protein becomes insoluble upon intracellular iron depletion; protein abundance increases in response to DNA replication stress	biological_process	NAD(P)H nitroreductase activity	nucleus|cytoplasm
YDR255C	YDR255C	RMD5	hom	Verified	2.35910549306529	0.00915952364127288	no	146	0.00623648226155282	80	NA	FT	KETONE METABOLISM|CELL CYCLE|CARBOHYDRATE METABOLISM|PROTEOLYSIS			Component of GID Complex that confers ubiquitin ligase (U3) activity; necessary for polyubiquitination and degradation of the gluconeogenic enzyme fructose-1,6-bisphosphatase; forms dimer with Fyv10p that is then recruited to GID Complex by Gid8p; also required for sporulation; conserved protein that has a degenerate RING finger domain	negative regulation of gluconeogenesis|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	ubiquitin-protein ligase activity	cytosol|GID complex
YHR032W	YHR032W	ERC1	hom	Verified	2.35885710039874	0.00916565659159337	no	147	0.0106014514160976	84	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM			Member of the multi-drug and toxin extrusion (MATE) family of the multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter superfamily; overproduction confers ethionine resistance and accumulation of S-adenosylmethionine	S-adenosylmethionine biosynthetic process|transmembrane transport	antiporter activity	integral to membrane
YPL125W	YPL125W	KAP120	hom	Verified	2.33514073574907	0.00976803494399633	no	148	0.0126746757269079	116	NA	FT	PROTEIN LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	Karyopherin responsible for the nuclear import of ribosome maturation factor Rfp1p	protein import into nucleus|transcription factor import into nucleus	protein transporter activity|structural constituent of nuclear pore	integral to membrane|nucleus|nuclear pore|cytoplasm
YPL057C	YPL057C	SUR1	hom	Verified	2.32148856950103	0.0101302451512568	no	149	0.00822998758924412	129	NA	FT	LIPID METABOLISM			Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit; forms a complex with regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Csh1p; SUR1 has a paralog, CSH1, that arose from the whole genome duplication	glycosphingolipid biosynthetic process|mannosyl-inositol phosphorylceramide metabolic process|sphingolipid biosynthetic process	mannosyltransferase activity|transferase activity, transferring glycosyl groups	integral to membrane|intracellular
YHR154W	YHR154W	RTT107	hom	Verified	2.31962388217496	0.010180616380709	no	150	0.0190727000582131	164	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS	UBIQUITIN LIGASE COMPLEX	Protein implicated in Mms22-dependent DNA repair during S phase; involved in recruiting the SMC5/6 complex to double-strand breaks; DNA damage induces phosphorylation by Mec1p at one or more SQ/TQ motifs; interacts with Mms22p and Slx4p; has four BRCT domains; has a role in regulation of Ty1 transposition; relative distribution to nuclear foci increases upon DNA replication stress	negative regulation of transposition, RNA-mediated|double-strand break repair	molecular_function	Cul8-RING ubiquitin ligase complex|nucleus
YBR267W	YBR267W	REI1	hom	Verified	2.3142102817166	0.0103280951293038	no	151	0.0278922791741005	199	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RIBOSOME BIOGENESIS|CELL DIVISION		RIBOSOME	Cytoplasmic pre-60S factor; required for the correct recycling of shuttling factors Alb1, Arx1 and Tif6 at the end of the ribosomal large subunit biogenesis; involved in bud growth in the mitotic signaling network	ribosomal large subunit biogenesis|nucleocytoplasmic transport|mitotic cell cycle|budding cell bud growth	sequence-specific DNA binding	cytosolic large ribosomal subunit|preribosome, large subunit precursor|cytoplasm
YJR037W_d	YJR037W	YJR037W	hom	Dubious	2.30832457225029	0.0104905453696926	no	152	0.00635984111765177	51	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene HUL4/YJR036C; deletion mutant has decreased spore survival in Drosophila feces	Unknown	Unknown	Unknown
YKL033W-A_p	YKL033W-A	YKL033W-A	hom	Uncharacterized	2.30615652467444	0.0105509439226018	no	153	0.0195006163082733	153	NA					Putative protein of unknown function; similar to uncharacterized proteins from other fungi	biological_process	molecular_function	cellular_component
YER028C	YER028C	MIG3	hom	Verified	2.30206431215814	0.0106657728144707	no	154	0.00987192146393744	103	NA	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Transcriptional regulator; partially nonfunctional in S288C strains but has a major role in catabolite repression and ethanol response in some other strains; involved in response to toxic agents; phosphorylation by Snf1p or the Mec1p pathway inactivates Mig3p, allowing induction of damage response genes; MIG3 has a paralog, MIG2, that arose from the whole genome duplication	cellular response to UV|negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage|response to DNA damage stimulus	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding	nuclear chromatin
YKL135C	YKL135C	APL2	hom	Verified	2.29901175173496	0.0107521360020728	no	155	0.0265617753943137	155	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS|PLASMA MEMBRANE		Beta-adaptin subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in clathrin-dependent Golgi protein sorting; protein abundance increases in response to DNA replication stress	Golgi to vacuole transport|vesicle-mediated transport	clathrin binding	AP-1 adaptor complex
YLR201C	YLR201C	COQ9	hom	Verified	2.29742231288306	0.0107973450599965	no	156	0.00898392215277712	95	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes	ubiquinone biosynthetic process|aerobic respiration	molecular_function	mitochondrion|mitochondrial inner membrane
YLR227C	YLR227C	ADY4	hom	Verified	2.29639364039675	0.0108266921364174	no	157	0.00657771212938684	77	NA	FT	CELL CYCLE|CELL DIVISION	NUCLEUS|CYTOSKELETON		Structural component of the meiotic outer plaque, which is a membrane-organizing center that assembles on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane	sporulation resulting in formation of a cellular spore	structural molecule activity	spindle pole body
YMR153W	YMR153W	NUP53	hom	Verified	2.29295836762662	0.0109252009668364	no	158	0.0082785045982491	94	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|CELL DIVISION|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	FG-nucleoporin component of central core of nuclear pore complex (NPC); also part of the NPC nuclear basket; contributes directly to nucleocytoplasmic transport; involved in regulation of transcription and mitosis; induces membrane tubulation, which may contribute to nuclear pore assembly; NUP53 has a paralog, ASM4, that arose from the whole genome duplication	positive regulation of transcription, DNA-dependent|NLS-bearing substrate import into nucleus|regulation of protein desumoylation|nuclear pore organization|protein import into nucleus|regulation of mitosis|mitotic cell cycle spindle assembly checkpoint	nucleocytoplasmic transporter activity|phospholipid binding|single-stranded DNA binding	nuclear pore central transport channel|nuclear pore nuclear basket|integral to membrane|nuclear pore
YJR145C	YJR145C	RPS4A	hom	Verified	2.28823385030464	0.011061953208003	no	159	0.00916169962920248	79	NA	FT	TRANSLATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; mutation affects 20S pre-rRNA processing; homologous to mammalian ribosomal protein S4, no bacterial homolog; RPS4A has a paralog, RPS4B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic small ribosomal subunit|cytoplasm|90S preribosome
YDR083W	YDR083W	RRP8	hom	Verified	2.26917832219457	0.0116287419868588	no	160	0.010709150680367	110	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS|CHROMOSOME		Nucleolar S-adenosylmethionine-dependent rRNA methyltransferase; methylates adenine (m1A) of the large subunit (LSU) rRNA at position 645; involved in pre-rRNA cleavage at site A2; mutation is synthetically lethal with a gar1 mutation; deletion disrupts telomere maintenance by influencing the expression of neighboring gene STN1	rRNA processing	methyltransferase activity	nucleolus
YLR278C_p	YLR278C	YLR278C	hom	Uncharacterized	2.26014367628501	0.0119061675896114	no	161	0.0159127731144262	96	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Zinc-cluster protein; GFP-fusion protein localizes to the nucleus; mutant shows moderate growth defect on caffeine; has a prion-domain like fragment that increases frequency of [URE3]; YLR278C is not an essential gene	biological_process	sequence-specific DNA binding	nucleus
YLR387C	YLR387C	REH1	hom	Verified	2.24737015979569	0.0123081902111621	no	162	0.0189771619996921	97	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS		RIBOSOME	Cytoplasmic 60S subunit biogenesis factor, associates with pre-60S particles; similar to Rei1p and shares partially redundant function in cytoplasmic 60S subunit maturation; contains dispersed C2H2 zinc finger domains	ribosomal large subunit biogenesis|budding cell bud growth	molecular_function	cytosolic large ribosomal subunit|preribosome, large subunit precursor|cytoplasm
YMR158W-B_d	YMR158W-B	YMR158W-B	hom	Dubious	2.24478803020383	0.0123908717792713	no	163	0.00860998008766259	97	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene ATG16/YMR159C	Unknown	Unknown	Unknown
YER132C	YER132C	PMD1	hom	Verified	2.24308710133205	0.0124455991426921	no	164	0.0145380790150906	108	NA	FT	CELL CYCLE			Protein with an N-terminal kelch-like domain, putative negative regulator of early meiotic gene expression; required, with Mds3p, for growth under alkaline conditions	sporulation resulting in formation of a cellular spore	molecular_function	cytoplasm
YGR271W	YGR271W	SLH1	hom	Verified	2.23456497891572	0.0127229610805703	no	165	0.0145181363618512	134	NA	FT	TRANSLATION		RIBOSOME	Putative RNA helicase related to Ski2p, involved in translation inhibition of non-poly(A) mRNAs; required for repressing propagation of dsRNA viruses	cytoplasmic translation|regulation of translation	RNA helicase activity	polysomal ribosome|cytoplasm
YCL029C	YCL029C	BIK1	hom	Verified	2.22470770088181	0.0130504334844662	no	166	0.014742352881102	127	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION	NUCLEUS|SITE OF POLARIZED GROWTH|CHROMOSOME|CYTOSKELETON	KINETOCHORE	Microtubule-associated protein, component of the interface between microtubules and kinetochore, involved in sister chromatid separation; essential in polyploid cells but not in haploid or diploid cells; ortholog of mammalian CLIP-170	karyogamy involved in conjugation with cellular fusion|mitotic anaphase B|negative regulation of microtubule polymerization|nuclear migration involved in conjugation with cellular fusion|mitotic spindle organization in nucleus|mitotic spindle elongation	microtubule binding|protein homodimerization activity	spindle microtubule|microtubule plus end|spindle pole body|cell cortex|condensed nuclear chromosome kinetochore|mating projection tip|kinetochore|spindle
YAL037C-A_p	YAL037C-A	YAL037C-A	hom	Uncharacterized	2.22392170293773	0.013076856298333	no	167	0.0137491729967895	101	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YAL048C	YAL048C	GEM1	hom	Verified	2.2231946964284	0.0131013371549887	no	168	0.00954628787193574	89	NA	FT	SIGNALING|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION		Outer mitochondrial membrane GTPase, subunit of the ERMES complex; potential regulatory subunit of the ERMES complex that links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth; cells lacking Gem1p contain collapsed, globular, or grape-like mitochondria; ortholog of metazoan Miro GTPases	mitochondrion inheritance|regulation of mitochondrion organization|phospholipid homeostasis	GTPase activity|calcium ion binding	mitochondrial outer membrane|ERMES complex|mitochondrion
YCR027C	YCR027C	RHB1	hom	Verified	2.22204156404786	0.0131402484020488	no	169	0.0141511252775769	110	NA	FT	VESICLE-MEDIATED TRANSPORT|SIGNALING|NUCLEOTIDE METABOLISM	PLASMA MEMBRANE		Putative Rheb-related GTPase involved in regulating canavanine resistance and arginine uptake; member of the Ras superfamily of G-proteins	lysine transport|retrograde transport, endosome to Golgi|arginine transport	GTPase activity	extrinsic to plasma membrane
YHL036W	YHL036W	MUP3	hom	Verified	2.21627455430553	0.0133363523063165	no	170	0.0157997578656709	122	NA					Low affinity methionine permease, similar to Mup1p	amino acid transport	L-methionine transmembrane transporter activity	integral to membrane|membrane
YGR108W	YGR108W	CLB1	hom	Verified	2.2153645538295	0.013367526124328	no	171	0.0104273660692365	102	NA	FT	CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION	NUCLEUS		B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome	G2/M transition of mitotic cell cycle|meiotic G2/MI transition|regulation of cyclin-dependent protein kinase activity|mitotic spindle organization in nucleus|positive regulation of spindle pole body separation	cyclin-dependent protein kinase regulator activity	cyclin-dependent protein kinase holoenzyme complex|nucleus|cytoplasm
YBR282W	YBR282W	MRPL27	hom	Verified	2.20455204121371	0.0137427721449373	no	172	0.0131489753036	153	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit; homolog of human Bcl-2 interacting protein BMRP	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YOR184W	YOR184W	SER1	hom	Verified	2.20413817254733	0.0137573141521723	no	173	0.0163145194321063	126	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			3-phosphoserine aminotransferase; catalyzes the formation of phosphoserine from 3-phosphohydroxypyruvate, required for serine and glycine biosynthesis; regulated by the general control of amino acid biosynthesis mediated by Gcn4p; protein abundance increases in response to DNA replication stress	serine family amino acid biosynthetic process|L-serine biosynthetic process|purine nucleobase biosynthetic process	O-phospho-L-serine:2-oxoglutarate aminotransferase activity	cytoplasm
YJL045W	YJL045W	YJL045W	hom	Verified	2.2000357270538	0.0139021801606191	no	174	0.0133887543208114	103	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Minor succinate dehydrogenase isozyme; homologous to Sdh1p, the major isozyme reponsible for the oxidation of succinate and transfer of electrons to ubiquinone; induced during the diauxic shift in a Cat8p-dependent manner	cellular respiration	succinate dehydrogenase (ubiquinone) activity	mitochondrion
YDR179W-A_p	YDR179W-A	YDR179W-A	hom	Uncharacterized	2.19981058216075	0.0139101684344548	no	175	0.0134379965020265	92	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YHR205W	YHR205W	SCH9	hom	Verified	2.19805062305944	0.0139727493215868	no	176	0.0100461553818547	104	NA	FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|RIBOSOME BIOGENESIS|PROTEIN PHOSPHORYLATION|RESPONSE TO OXIDATIVE STRESS	NUCLEUS|CHROMOSOME		AGC family protein kinase; functional ortholog of mammalian S6 kinase; phosphorylated by Tor1p and required for TORC1-mediated regulation of ribosome biogenesis, translation initiation, and entry into G0 phase; involved in transactivation of osmostress-responsive genes; regulates G1 progression, cAPK activity and nitrogen activation of the FGM pathway; integrates nutrient signals and stress signals from sphingolipids to regulate lifespan	protein phosphorylation|age-dependent response to oxidative stress involved in chronological cell aging|replicative cell aging|regulation of protein localization|positive regulation of transcription from RNA polymerase III promoter|positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase I promoter|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|regulation of cell size|regulation of response to osmotic stress	protein serine/threonine kinase activity	chromatin|fungal-type vacuole membrane|nucleus|cytoplasm
YLR388W	YLR388W	RPS29A	hom	Verified	2.19786557287528	0.0139793434434543	no	177	0.0339993714459176	162	NA	FT	TRANSLATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S29 and bacterial S14; RPS29A has a paralog, RPS29B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic small ribosomal subunit
YMR080C	YMR080C	NAM7	hom	Verified	2.19548206519014	0.0140645180153745	no	178	0.020913231913304	87	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|RNA LOCALIZATION|GENE SILENCING	NUCLEUS		ATP-dependent RNA helicase of the SFI superfamily; involved in nonsense mediated mRNA decay; required for efficient translation termination at nonsense codons and targeting of NMD substrates to P-bodies; involved in telomere maintenance; forms cytoplasmic foci upon DNA replication stress	nuclear-transcribed mRNA catabolic process|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay|intracellular mRNA localization|translational frameshifting|regulation of translational termination|chromatin silencing at silent mating-type cassette|protein ubiquitination	RNA-dependent ATPase activity|ATP-dependent RNA helicase activity|nucleic acid binding	mitochondrion|polysome|cytoplasm
YAR028W_p	YAR028W	YAR028W	hom	Uncharacterized	2.19431757521947	0.0141062934111679	no	179	0.0199907482320558	119	NA					Putative integral membrane protein, member of DUP240 gene family; GFP-fusion protein is induced in response to the DNA-damaging agent MMS	biological_process	molecular_function	cellular_component
YGL218W_d	YGL218W	YGL218W	hom	Dubious	2.1812264994895	0.0145833338643506	no	180	0.0314237459746763	156	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 93% of ORF overlaps the verified gene MDM34; deletion in cyr1 mutant results in loss of stress resistance	Unknown	Unknown	Unknown
YIL103W	YIL103W	DPH1	hom	Verified	2.17221303428155	0.0149197989953969	no	181	0.0181095416443443	136	NA					Protein required, along with Dph2p, Kti11p, Jjj3p, and Dph5p, for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); may act in a complex with Dph2p and Kti11p	peptidyl-diphthamide biosynthetic process from peptidyl-histidine	molecular_function	cytoplasm
YBR284W_p	YBR284W	YBR284W	hom	Uncharacterized	2.16899077677716	0.0150416920718026	no	182	0.0158883473121171	149	NA	FT	NUCLEOTIDE METABOLISM			Putative metallo-dependent hydrolase superfamily protein; similar to AMP deaminases but lacks key catalytic residues and does not rescue purine nucleotide metabolic defect of quadruple aah1 ade8 amd1 his1 mutant; null mutant exhibits longer telomeres, altered Ty mobility, decreased resistance to rapamycin and wortmannin; induced in response to hydrostatic pressure; not an essential gene; YBR284W has a paralog, YJL070C, that arose from the whole genome duplication	biological_process	AMP deaminase activity|molecular_function	cellular_component
YDL052C	YDL052C	SLC1	hom	Verified	2.16190983139774	0.0153125635261744	no	183	0.0234102767829335	138	NA	FT	LIPID METABOLISM			1-acyl-sn-glycerol-3-phosphate acyltransferase, catalyzes the acylation of lysophosphatidic acid to form phosphatidic acid, a key intermediate in lipid metabolism; enzymatic activity detected in lipid particles and microsomes	glycerophospholipid biosynthetic process	1-acylglycerol-3-phosphate O-acyltransferase activity	lipid particle
YDL122W	YDL122W	UBP1	hom	Verified	2.16155393164982	0.0153262878292258	no	184	0.0134358695757728	106	NA	FT	PROTEOLYSIS	ENDOPLASMIC RETICULUM		Ubiquitin-specific protease that removes ubiquitin from ubiquitinated proteins; cleaves at the C terminus of ubiquitin fusions irrespective of their size; capable of cleaving polyubiquitin chains	protein deubiquitination	ubiquitin-specific protease activity	endoplasmic reticulum|cytoplasm
YBR187W_p	YBR187W	GDT1	hom	Uncharacterized	2.15901547627312	0.0154244831442626	no	185	0.0175882057043297	168	NA					Putative protein of unknown function; expression is reduced in a gcr1 null mutant; GFP-fusion protein localizes to the vacuole; expression pattern and physical interactions suggest a possible role in ribosome biogenesis	biological_process	molecular_function	integral to membrane|fungal-type vacuole
YOL059W	YOL059W	GPD2	hom	Verified	2.15747577768134	0.0154843062333498	no	186	0.0289278949663781	143	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM	MITOCHONDRION		NAD-dependent glycerol 3-phosphate dehydrogenase, homolog of Gpd1p, expression is controlled by an oxygen-independent signaling pathway required to regulate metabolism under anoxic conditions; located in cytosol and mitochondria; constitutively active but is inactivated via phosphorylation by energy-stress responsive kinase SNF1	NADH oxidation|glycerol metabolic process	glycerol-3-phosphate dehydrogenase [NAD+] activity	cytosol|mitochondrion
YMR021C	YMR021C	MAC1	hom	Verified	2.14972778619281	0.0157883766094402	no	187	0.0906687227025449	449	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|ION HOMEOSTASIS|ION HOMEOSTASIS	NUCLEUS		Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport	cellular copper ion homeostasis|positive regulation of protein catabolic process|positive regulation of transcription from RNA polymerase II promoter	core promoter proximal region DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YGR107W_d	YGR107W	YGR107W	hom	Dubious	2.1479893137431	0.0158573021977673	no	188	0.0157511165302493	123	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YIL148W	YIL148W	RPL40A	hom	Verified	2.14719678849305	0.0158888091419326	no	189	0.0175011790819272	108	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RESPONSE TO DNA DAMAGE|TRANSLATION	NUCLEUS	RIBOSOME	Ubiquitin-ribosomal 60S subunit protein L40A fusion protein; cleaved to yield ubiquitin and ribosomal protein L40A; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; homologous to mammalian ribosomal protein L40, no bacterial homolog; RPL40A has a paralog, RPL40B, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress	cytoplasmic translation|protein ubiquitination|ribosome biogenesis	structural constituent of ribosome|protein tag	cytosolic large ribosomal subunit
YMR250W	YMR250W	GAD1	hom	Verified	2.14180000290864	0.0161047896024008	no	190	0.0184402104169152	140	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|RESPONSE TO OXIDATIVE STRESS			Glutamate decarboxylase, converts glutamate into gamma-aminobutyric acid (GABA) during glutamate catabolism; involved in response to oxidative stress	cellular response to oxidative stress|glutamate catabolic process	calmodulin binding|glutamate decarboxylase activity	cytoplasm
YBR292C_d	YBR292C	YBR292C	hom	Dubious	2.13727487063033	0.0162878207577264	no	191	0.0146218497640178	150	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR292C is not an essential gene	Unknown	Unknown	Unknown
YKR031C	YKR031C	SPO14	hom	Verified	2.13544810806991	0.0163622123063964	no	192	0.0142094195513866	131	NA	FT	VESICLE-MEDIATED TRANSPORT|CELL CYCLE|LIPID METABOLISM	NUCLEUS		Phospholipase D; catalyzes the hydrolysis of phosphatidylcholine, producing choline and phosphatidic acid; involved in Sec14p-independent secretion; required for meiosis and spore formation; differently regulated in secretion and meiosis; participates in transcription initiation and/or early elongation of specific genes; interacts with foot domain of RNA polymerase II; deletion results in abnormal CTD-Ser5 phosphorylation of RNA polymerase II at specific promoter regions	phospholipid metabolic process|exocytosis|cell morphogenesis involved in conjugation with cellular fusion|ascospore-type prospore assembly	phospholipase D activity|phosphatidylinositol-3-phosphate binding	endosome|nucleus|prospore membrane
YBR090C_p	YBR090C	YBR090C	hom	Uncharacterized	2.12956837918626	0.0166036319801736	no	193	0.00959645143511186	63	NA	FT		NUCLEUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus	biological_process	molecular_function	nucleus|cytoplasm
YMR082C_d	YMR082C	YMR082C	hom	Dubious	2.12915813553554	0.0166205896258403	no	194	0.0224628360885038	109	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YOR061W	YOR061W	CKA2	hom	Verified	2.12311536021739	0.0168720930898515	no	195	0.0259906664482143	231	NA	FF|FT	RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION	NUCLEUS		Alpha' catalytic subunit of casein kinase 2 (CK2); CK2 is a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases; protein abundance increases in response to DNA replication stress; regulates Fkh1p-mediated donor preference during mating-type switching	regulation of transcription from RNA polymerase I promoter|chronological cell aging|protein phosphorylation|regulation of transcription from RNA polymerase III promoter|response to DNA damage stimulus	protein serine/threonine kinase activity	protein kinase CK2 complex|UTP-C complex
YDR140W	YDR140W	MTQ2	hom	Verified	2.1214483931978	0.0169420432358763	no	196	0.0144124807492871	134	NA	FT	TRANSLATION	NUCLEUS		S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; subunit of complex with Trm112p that methylates translation release factor Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; similar to E.coli PrmC	peptidyl-glutamine methylation|regulation of translation	protein methyltransferase activity|S-adenosylmethionine-dependent methyltransferase activity	eRF1 methyltransferase complex|nucleus|cytoplasm
YGL020C	YGL020C	GET1	hom	Verified	2.11337999885129	0.0172841282386844	no	197	0.0366470401104054	238	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION|GOLGI APPARATUS		Subunit of the GET complex; involved in insertion of proteins into the ER membrane; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for normal mitochondrial morphology and inheritance	retrograde vesicle-mediated transport, Golgi to ER|protein insertion into ER membrane	protein anchor	mitochondrion|integral to membrane|endoplasmic reticulum|GET complex
YLR037C	YLR037C	PAU23	hom	Verified	2.10449262441777	0.0176677486591442	no	198	0.0181095779225891	130	NA	FT	CELL WALL ORG/BIOGENESIS			Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; member of the seripauperin multigene family encoded mainly in subtelomeric regions; expressed under anaerobic conditions, completely repressed during aerobic growth	biological_process	molecular_function	fungal-type cell wall
YNL324W_d	YNL324W	YNL324W	hom	Dubious	2.10407635159885	0.0176858936719847	no	199	0.0309363333181256	166	NA					Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YJL149W	YJL149W	DAS1	hom	Verified	2.10354517040649	0.0177090705429354	no	200	0.0235434396688396	185	NA	FT	PROTEOLYSIS		UBIQUITIN LIGASE COMPLEX	Putative SCF ubiquitin ligase F-box protein; interacts physically with both Cdc53p and Skp1 and genetically with CDC34; similar to putative F-box protein YDR131C	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	ubiquitin-protein ligase activity|protein binding, bridging	SCF ubiquitin ligase complex
YPL103C	YPL103C	FMP30	hom	Verified	2.10142331587179	0.0178019114988679	no	201	0.016564411167114	137	NA	FT	LIPID METABOLISM	MITOCHONDRION		Mitochondrial inner membrane protein with a role in maintaining mitochondrial morphology and normal cardiolipin levels; proposed to be involved in N-acylethanolamine metabolism; related to mammalian N-acylPE-specific phospholipase D	N-acylphosphatidylethanolamine metabolic process|N-acylethanolamine metabolic process	NAPE-specific phospholipase D activity	mitochondrion|integral to mitochondrial inner membrane
YGR085C	YGR085C	RPL11B	hom	Verified	2.10000080835437	0.0178643850085147	no	202	0.0263693665817347	131	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L11B; expressed at half the level of Rpl11Ap; involved in ribosomal assembly; depletion causes degradation of 60S proteins and RNA; homologous to mammalian ribosomal protein L11 and bacterial L5; RPL11B has a paralog, RPL11A, that arose from the whole genome duplication	cytoplasmic translation|ribosomal large subunit assembly	structural constituent of ribosome	cytosolic large ribosomal subunit
YHR199C	YHR199C	AIM46	hom	Verified	2.09632872280821	0.0180265202376763	no	203	0.037544716033268	191	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss	biological_process	molecular_function	mitochondrion
YPL092W	YPL092W	SSU1	hom	Verified	2.09238220541813	0.0182021696538573	no	204	0.0180772513585606	67	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Plasma membrane sulfite pump involved in sulfite metabolism and required for efficient sulfite efflux; major facilitator superfamily protein	sulfite transport	sulfite transmembrane transporter activity	integral to membrane|plasma membrane
YGR222W	YGR222W	PET54	hom	Verified	2.08997759552448	0.0183099061671366	no	205	0.0241931710128847	168	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial inner membrane protein; binds to the 5' UTR of the COX3 mRNA to activate its translation together with Pet122p and Pet494p; also binds to the COX1 Group I intron AI5 beta to facilitate exon ligation during splicing	Group I intron splicing|positive regulation of mitochondrial translation|mitochondrial respiratory chain complex IV biogenesis	translation regulator activity|RNA binding	mitochondrion|extrinsic to mitochondrial inner membrane|mitochondrial inner membrane|mitochondrial matrix
YLR133W	YLR133W	CKI1	hom	Verified	2.08976571264405	0.018319425391576	no	206	0.0382168691780483	160	NA	FT	LIPID METABOLISM			Choline kinase; catalyzes the first step in phosphatidylcholine synthesis via the CDP-choline (Kennedy pathway); exhibits some ethanolamine kinase activity contributing to phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway; CKI1 has a paralog, EKI1, that arose from the whole genome duplication	phosphatidylethanolamine biosynthetic process|phosphatidylcholine biosynthetic process	ethanolamine kinase activity|choline kinase activity	cytoplasm
YKL017C	YKL017C	HCS1	hom	Verified	2.0889538880959	0.0183559371228826	no	207	0.0114602044468539	123	NA	FT		NUCLEUS|CHROMOSOME		Hexameric DNA polymerase alpha-associated DNA helicase A involved in lagging strand DNA synthesis; contains single-stranded DNA stimulated ATPase and dATPase activities; replication protein A stimulates helicase and ATPase activities	lagging strand elongation	ATP-dependent 5'-3' DNA helicase activity	DNA helicase A complex|alpha DNA polymerase:primase complex
YDR194C	YDR194C	MSS116	hom	Verified	2.08793569289091	0.0184018179684788	no	208	0.0235735191399649	160	NA	FT	RNA PROCESSING|TRANSLATION	MITOCHONDRION		DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing	RNA folding|Group I intron splicing|Group II intron splicing	RNA binding|RNA strand annealing activity|ATP-dependent RNA helicase activity	mitochondrion|mitochondrial matrix
YMR294W-A_d	YMR294W-A	YMR294W-A	hom	Dubious	2.0846332664516	0.0185513012096131	no	209	0.0219716674842807	117	NA					Dubious open reading frame unlikely to encode a functional protein, substantially overlaps YMR295C; deletion causes sensitivity to unfolded protein response-inducing agents	Unknown	Unknown	Unknown
YGL014W	YGL014W	PUF4	hom	Verified	2.08325892136715	0.0186138144676689	no	210	0.0314052936276822	202	NA	FT	PROTEIN LOCALIZATION|CHROMATIN ORGANIZATION|TRANSLATION|GENE SILENCING			Member of the PUF protein family, which is defined by the presence of Pumilio homology domains that confer RNA binding activity; preferentially binds mRNAs encoding nucleolar ribosomal RNA-processing factors	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|negative regulation of translation|protein localization|negative regulation of chromatin silencing involved in replicative cell aging	mRNA binding	cytoplasm
YER115C	YER115C	SPR6	hom	Verified	2.08067882795443	0.0187316566248402	no	211	0.0214254748825782	120	NA	FT	CELL CYCLE			Protein of unknown function, expressed during sporulation; not required for sporulation, but gene exhibits genetic interactions with other genes required for sporulation	ascospore formation	molecular_function	cellular_component
YHR162W	YHR162W	MPC2	hom	Verified	2.07957014332343	0.0187824889398109	no	212	0.019242606747155	137	NA					Highly conserved subunit of the mitochondrial pyruvate carrier; a mitochondrial inner membrane complex comprised of Fmp37p/Mpc1p and either Mpc2p or Fmp43p/Mpc3p mediates mitochondrial pyruvate uptake; more highly expressed in glucose-containing minimal medium than in lactate-containing medium	mitochondrial pyruvate transport	pyruvate transmembrane transporter activity	mitochondrion|integral to mitochondrial inner membrane
YER137C_p	YER137C	YER137C	hom	Uncharacterized	2.07580060384534	0.0189561982538717	no	213	0.0207231295560919	153	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YDR024W_d	YDR024W	FYV1	hom	Dubious	2.05986659078893	0.0197056481892725	no	214	0.0272434097453535	168	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; mutation decreases survival upon exposure to K1 killer toxin	Unknown	Unknown	Unknown
YGL214W_d	YGL214W	YGL214W	hom	Dubious	2.05773415075643	0.0198078301093955	no	215	0.0178139162134128	115	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; deletion mutation phenotype is likely due to the overlapping verified ORF SKI8/YGL213C	Unknown	Unknown	Unknown
YBR019C	YBR019C	GAL10	hom	Verified	2.05760437245665	0.0198140632959174	no	216	0.0157457470166858	120	NA	FT	CARBOHYDRATE METABOLISM			UDP-glucose-4-epimerase, catalyzes the interconversion of UDP-galactose and UDP-D-glucose in galactose metabolism; also catalyzes the conversion of alpha-D-glucose or alpha-D-galactose to their beta-anomers	galactose catabolic process via UDP-galactose	aldose 1-epimerase activity|UDP-glucose 4-epimerase activity	cytosol
YLR318W	YLR318W	EST2	hom	Verified	2.05571395852464	0.0199050478340958	no	217	0.0185835727527149	146	NA	FT		NUCLEUS|CHROMOSOME		Reverse transcriptase subunit of the telomerase holoenzyme, essential for telomerase core catalytic activity, involved in other aspects of telomerase assembly and function; mutations in human homolog are associated with aplastic anemia	telomere maintenance via telomerase|replicative cell aging	telomerase activity|telomeric template RNA reverse transcriptase activity|telomeric DNA binding	telomerase catalytic core complex|nucleolus|nucleus|telomerase holoenzyme complex
YCL001W-B_p	YCL001W-B	YCL001W-B	hom	Uncharacterized	2.05097039768779	0.0201349148146126	no	218	0.0235410914093339	86	NA					Putative protein of unknown function; present in a region duplicated between chromosomes XIV and III; YCL001W-B has a paralog, DOM34, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YER166W	YER166W	DNF1	hom	Verified	2.04787307870399	0.0202862186829519	no	219	0.026428256241811	173	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION|GOLGI APPARATUS|PLASMA MEMBRANE		Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase	intracellular protein transport|phospholipid translocation|endocytosis|establishment or maintenance of cell polarity	phospholipid-translocating ATPase activity|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism	mitochondrion|integral to membrane|plasma membrane
YMR263W	YMR263W	SAP30	hom	Verified	2.04774737565781	0.0202923795680665	no	220	0.0297720857961372	218	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS|CHROMOSOME		Subunit of a histone deacetylase complex, along with Rpd3p and Sin3p, that is involved in silencing at telomeres, rDNA, and silent mating-type loci; involved in telomere maintenance	positive regulation of transcription from RNA polymerase II promoter in response to heat stress|negative regulation of chromatin silencing at silent mating-type cassette|negative regulation of transcription from RNA polymerase I promoter|negative regulation of chromatin silencing at telomere|negative regulation of chromatin silencing at rDNA|positive regulation of transcription from RNA polymerase II promoter	histone deacetylase activity	histone deacetylase complex|Rpd3L-Expanded complex|Rpd3L complex
YHR063C	YHR063C	PAN5	hom	Verified	2.03749161935835	0.0208004004640959	no	221	0.0257094790532532	133	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM			2-dehydropantoate 2-reductase, part of the pantothenic acid pathway, structurally homologous to E. coli panE	pantothenate biosynthetic process	2-dehydropantoate 2-reductase activity	cytoplasm
YMR326C_d	YMR326C	YMR326C	hom	Dubious	2.03390541962326	0.0209805662161031	no	222	0.0198767663325602	106	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the telomere on the right arm of chromosome 13	Unknown	Unknown	Unknown
YNL202W	YNL202W	SPS19	hom	Verified	2.02983941808193	0.0211864323725992	no	223	0.0296562486744716	196	NA	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS			Peroxisomal 2,4-dienoyl-CoA reductase, auxiliary enzyme of fatty acid beta-oxidation; homodimeric enzyme required for growth and sporulation on petroselineate medium; expression induced during late sporulation and in the presence of oleate	fatty acid catabolic process|ascospore formation	2,4-dienoyl-CoA reductase (NADPH) activity	peroxisomal matrix
YKR084C	YKR084C	HBS1	hom	Verified	2.02826092376171	0.0212668124379564	no	224	0.0232907590768404	183	NA	FT	TRANSLATION|NUCLEOTIDE METABOLISM			GTPase with similarity to translation release factors; together with binding partner Dom34p, facilitates ribosomal subunit dissociation and peptidyl-tRNA release when translation is stalled; genetically implicated in mRNA no-go decay	nuclear-transcribed mRNA catabolic process, no-go decay|ribosome disassembly|nonfunctional rRNA decay	ribosome binding|GTPase activity	cytoplasm
YKL160W	YKL160W	ELF1	hom	Verified	2.02632809309975	0.0213655871193341	no	225	0.0194646692626562	144	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION	NUCLEUS		Transcription elongation factor that contains a conserved zinc finger domain; implicated in the maintenance of proper chromatin structure in actively transcribed regions; deletion inhibits Brome mosaic virus (BMV) gene expression	regulation of transcription by chromatin organization|transcription elongation from RNA polymerase II promoter	RNA polymerase II core binding	transcription elongation factor complex|nucleus
YDR084C	YDR084C	TVP23	hom	Verified	2.02006934033516	0.0216880977817059	no	226	0.0138436546768327	138	NA	FT	VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern	vesicle-mediated transport	molecular_function	integral to membrane|integral to Golgi membrane|cytoplasm
YML096W_p	YML096W	YML096W	hom	Uncharacterized	2.01506793546483	0.0219487656831359	no	227	0.0319092512981982	156	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Putative protein of unknown function with similarity to asparagine synthetases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YML096W is not an essential gene and partially overlaps the verified gene RAD10	biological_process	molecular_function	cytoplasm
YDL089W	YDL089W	NUR1	hom	Verified	2.01461331181537	0.0219725907928955	no	228	0.0276164817480731	162	NA	FT		ENDOMEMBRANE SYSTEM|NUCLEUS		Protein of unknown function; interacts with Csm1p, Lrs4p; required for rDNA repeat stability; null mutant causes increase in unequal sister-chromatid exchange; GFP-fusion protein localizes to the nuclear periphery, possible Cdc28p substrate	maintenance of rDNA	molecular_function	nuclear periphery
YKL194C	YKL194C	MST1	hom	Verified	2.01317257139489	0.0220482388518957	no	229	0.0467529109673635	222	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial threonyl-tRNA synthetase; aminoacylates both the canonical threonine tRNA tT(UGU)Q1 and the unusual threonine tRNA tT(XXX)Q2 in vitro	mitochondrial threonyl-tRNA aminoacylation	threonine-tRNA ligase activity	mitochondrion
YEL018W	YEL018W	EAF5	hom	Verified	2.01269006986275	0.0220736223515191	no	230	0.0285497383186348	143	NA	FT	CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE	NUCLEUS	HISTONE ACETYLTRANSFERASE	Esa1p-associated factor, non-essential subunit of the NuA4 acetyltransferase complex	DNA repair	molecular_function	nucleus|NuA4 histone acetyltransferase complex
YNL005C	YNL005C	MRP7	hom	Verified	2.01094819034404	0.0221654647215508	no	231	0.057676142095823	225	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation	structural constituent of ribosome|peptidyltransferase activity	mitochondrion|mitochondrial large ribosomal subunit
YMR267W	YMR267W	PPA2	hom	Verified	2.00237997569595	0.0226219402164839	no	232	0.0395700910251249	255	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Mitochondrial inorganic pyrophosphatase, required for mitochondrial function and possibly involved in energy generation from inorganic pyrophosphate	aerobic respiration	inorganic diphosphatase activity	mitochondrion
YOR172W	YOR172W	YRM1	hom	Verified	1.99998124574044	0.0227511445277692	no	233	0.0221259090704219	145	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Zn2-Cys6 zinc-finger transcription factor that activates genes involved in multidrug resistance; paralog of Yrr1p, acting on an overlapping set of target genes	regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding|nucleic acid binding transcription factor activity	nucleus|cytoplasm
YGR261C	YGR261C	APL6	hom	Verified	1.99539529193695	0.0229998920133638	no	234	0.0367258713041451	240	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Beta3-like subunit of the yeast AP-3 complex; functions in transport of alkaline phosphatase to the vacuole via the alternate pathway; exists in both cytosolic and peripherally associated membrane-bound pools	vesicle-mediated transport|Golgi to vacuole transport	molecular_function	AP-3 adaptor complex
YLR342W	YLR342W	FKS1	hom	Verified	1.99389129704111	0.0230819676255467	no	235	0.0239197399230499	162	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	MITOCHONDRION|PLASMA MEMBRANE|CYTOSKELETON		Catalytic subunit of 1,3-beta-D-glucan synthase, functionally redundant with alternate catalytic subunit Gsc2p; binds to regulatory subunit Rho1p; involved in cell wall synthesis and maintenance; localizes to sites of cell wall remodeling	(1->3)-beta-D-glucan biosynthetic process|positive regulation of endocytosis|regulation of cell size	1,3-beta-D-glucan synthase activity	mitochondrion|1,3-beta-D-glucan synthase complex|integral to membrane|plasma membrane|cellular bud neck|cellular bud tip|actin cortical patch
YPR047W	YPR047W	MSF1	hom	Verified	1.99363317209311	0.0230960787197837	no	236	0.0331874960209086	205	NA	FT	KETONE METABOLISM|RNA PROCESSING|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial phenylalanyl-tRNA synthetase, active as a monomer, unlike the cytoplasmic subunit which is active as a dimer complexed to a beta subunit dimer; similar to the alpha subunit of E. coli phenylalanyl-tRNA synthetase	phenylalanyl-tRNA aminoacylation|mitochondrial phenylalanyl-tRNA aminoacylation	phenylalanine-tRNA ligase activity	mitochondrion
YER184C_p	YER184C	YER184C	hom	Uncharacterized	1.99108255047735	0.023235906248772	no	237	0.0263237742278	146	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Putative zinc cluster protein; deletion confers sensitivity to Calcufluor white, and prevents growth on glycerol or lactate as sole carbon source	biological_process	sequence-specific DNA binding	cellular_component
YNL193W_p	YNL193W	YNL193W	hom	Uncharacterized	1.98801318630144	0.0234051158140672	no	238	0.017664525079873	151	NA					Putative protein of unknown function; exhibits a two-hybrid interaction with Yhr151cp in a large-scale analysis	biological_process	molecular_function	cellular_component
YOR381W	YOR381W	FRE3	hom	Verified	1.98695541406901	0.023463668970028	no	239	0.0239250423948448	143	NA	FT	ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|GEN. OF PRECURSOR METABOLITES AND ENERGY	PLASMA MEMBRANE		Ferric reductase, reduces siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels	cellular iron ion homeostasis|siderophore transport	ferric-chelate reductase activity	integral to membrane|plasma membrane
YGR052W_p	YGR052W	FMP48	hom	Uncharacterized	1.98021751450345	0.0238395463246	no	240	0.0375485582738478	198	NA	FT	PROTEIN PHOSPHORYLATION	MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; induced by treatment with 8-methoxypsoralen and UVA irradiation	protein phosphorylation	protein kinase activity	mitochondrion
YGL009C	YGL009C	LEU1	hom	Verified	1.97796394736203	0.0239663869853977	no	241	0.022860751674982	116	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Isopropylmalate isomerase, catalyzes the second step in the leucine biosynthesis pathway	leucine biosynthetic process	3-isopropylmalate dehydratase activity	cytosol
YDR350C	YDR350C	ATP22	hom	Verified	1.97148113902218	0.0243344341387749	no	242	0.0274939752982483	128	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Specific translational activator for the mitochondrial ATP6 mRNA, encoding a subunit of F1F0 ATP synthase; localized to the mitochondrial inner membrane	proton-transporting ATP synthase complex biogenesis|positive regulation of mitochondrial translation	translation regulator activity	mitochondrial inner membrane
YGL027C	YGL027C	CWH41	hom	Verified	1.96777407462618	0.0245470192082561	no	243	0.0372589506675675	152	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Processing alpha glucosidase I, ER type II integral membrane N-glycoprotein involved in assembly of cell wall beta 1,6 glucan and asparagine-linked protein glycosylation; also involved in ER protein quality control and sensing of ER stress	fungal-type cell wall biogenesis|protein N-linked glycosylation	mannosyl-oligosaccharide glucosidase activity	endoplasmic reticulum membrane
YLR421C	YLR421C	RPN13	hom	Verified	1.96043372568275	0.0249725585813968	no	244	0.0290510687309424	137	NA	FT	PROTEOLYSIS	NUCLEUS		Subunit of the 19S regulatory particle of the 26S proteasome lid; acts as a ubiquitin receptor for the proteasome; null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; protein abundance increases in response to DNA replication stress	ubiquitin-dependent protein catabolic process	ubiquitin binding	proteasome storage granule|proteasome regulatory particle, lid subcomplex
YOR298W	YOR298W	MUM3	hom	Verified	1.95972995072741	0.0250136812599341	no	245	0.0252669665020773	138	NA	FT	LIPID METABOLISM|CELL WALL ORG/BIOGENESIS			Protein of unknown function involved in the organization of the outer spore wall layers; has similarity to the tafazzins superfamily of acyltransferases	ascospore wall assembly|phospholipid biosynthetic process	transferase activity, transferring acyl groups	cellular_component
YNR063W_p	YNR063W	YNR063W	hom	Uncharacterized	1.9533954069973	0.0253863800289449	no	246	0.0185525387268154	126	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Putative zinc-cluster protein of unknown function	biological_process	sequence-specific DNA binding	cellular_component
YNL220W	YNL220W	ADE12	hom	Verified	1.95113289898446	0.0255206192744286	no	247	0.017330817909673	114	NA	FT	NUCLEOTIDE METABOLISM			Adenylosuccinate synthase, catalyzes the first step in synthesis of adenosine monophosphate from inosine 5'monophosphate during purine nucleotide biosynthesis; exhibits binding to single-stranded autonomously replicating (ARS) core sequence	purine nucleotide biosynthetic process	DNA replication origin binding|adenylosuccinate synthase activity	cytoplasm
YHR008C	YHR008C	SOD2	hom	Verified	1.94863916725299	0.025669265621728	no	248	0.0679175413602976	279	NA	FF|FT	OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS	MITOCHONDRION		Mitochondrial manganese superoxide dismutase, protects cells against oxygen toxicity; phosphorylated	reactive oxygen species metabolic process|age-dependent response to oxidative stress involved in chronological cell aging|replicative cell aging|age-dependent response to reactive oxygen species involved in chronological cell aging	superoxide dismutase activity	mitochondrion|mitochondrial matrix
YLL044W_d	YLL044W	YLL044W	hom	Dubious	1.9482394361866	0.0256931600574327	no	249	0.0258818472715275	171	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcription of both YLL044W and the overlapping gene RPL8B is reduced in the gcr1 null mutant	Unknown	Unknown	Unknown
YML088W	YML088W	UFO1	hom	Verified	1.94690251746805	0.0257732113912228	no	250	0.0193852550091103	143	NA	FT	RESPONSE TO DNA DAMAGE|PROTEOLYSIS	NUCLEUS	UBIQUITIN LIGASE COMPLEX	F-box receptor protein, subunit of the Skp1-Cdc53-F-box receptor (SCF) E3 ubiquitin ligase complex; binds to phosphorylated Ho endonuclease, allowing its ubiquitylation by SCF and subsequent degradation	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|cellular response to methylmercury|response to DNA damage stimulus	ubiquitin-protein ligase activity|protein binding, bridging	SCF ubiquitin ligase complex|nucleus|cytoplasm
YLR225C_p	YLR225C	YLR225C	hom	Uncharacterized	1.94647397225711	0.0257989157394429	no	251	0.0289743143694621	172	NA	FT	RESPONSE TO OXIDATIVE STRESS			Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR225C is not an essential gene	biological_process	molecular_function	cytoplasm
YCL037C	YCL037C	SRO9	hom	Verified	1.94609431577321	0.0258217056371112	no	252	0.0471541184952794	262	NA	FT	TRANSLATION			Cytoplasmic RNA-binding protein; associates with translating ribosomes; involved in heme regulation of Hap1p as a component of the HMC complex, also involved in the organization of actin filaments; contains a La motif; SRO9 has a paralog, SLF1, that arose from the whole genome duplication	cytoplasmic translation	RNA binding	polysome
YLR099C	YLR099C	ICT1	hom	Verified	1.93760756681886	0.0263355593000065	no	253	0.0277164531769038	170	NA	FT	KETONE METABOLISM|LIPID METABOLISM			Lysophosphatidic acid acyltransferase; responsible for enhanced phospholipid synthesis during organic solvent stress; null displays increased sensitivity to Calcofluor white; highly expressed during organic solvent stress; ICT1 has a paralog, ECM18, that arose from the whole genome duplication	phosphatidic acid biosynthetic process	lysophosphatidic acid acyltransferase activity	cellular_component
YBL071C-B_p	YBL071C-B	YBL071C-B	hom	Uncharacterized	1.93546673406239	0.0264665235120437	no	254	0.0346506927768842	189	NA					Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching	biological_process	molecular_function	cellular_component
YLR329W	YLR329W	REC102	hom	Verified	1.93496270258431	0.0264974363700935	no	255	0.034081192049185	146	NA	FT	CELL CYCLE	NUCLEUS|CHROMOSOME		Protein involved in early stages of meiotic recombination; required for chromosome synapsis; forms a complex with Rec104p and Spo11p necessary during the initiation of recombination	meiotic DNA double-strand break formation|reciprocal meiotic recombination	molecular_function	condensed nuclear chromosome|nucleus
YOR369C	YOR369C	RPS12	hom	Verified	1.92698278726923	0.0269908875432638	no	256	0.0270937601787724	178	NA	FT	TRANSLATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S12, no bacterial homolog	cytoplasmic translation	structural constituent of ribosome	cytosolic small ribosomal subunit
YPR145W	YPR145W	ASN1	hom	Verified	1.92644283005977	0.0270245519221127	no	257	0.0334894275992027	207	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Asparagine synthetase; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway; ASN1 has a paralog, ASN2, that arose from the whole genome duplication	asparagine biosynthetic process	asparagine synthase (glutamine-hydrolyzing) activity	cytoplasm
YOR105W_p	YOR105W	YOR105W	hom	Uncharacterized	1.922822859565	0.0272511500991741	no	258	0.0260336842313043	166	NA					Protein of unknown function; expressed at both mRNA and protein levels	biological_process	molecular_function	cellular_component
YPR075C	YPR075C	OPY2	hom	Verified	1.92141211394969	0.0273398862636148	no	259	0.0183335690868421	138	NA	FT	CELL CYCLE|SIGNALING	PLASMA MEMBRANE		Integral membrane protein that acts as a membrane anchor for Ste50p; involved in the signaling branch of the high-osmolarity glycerol (HOG) pathway and as a regulator of the filamentous growth pathway; overproduction blocks cell cycle arrest in the presence of mating pheromone; relocalizes from vacuole to plasma membrane upon DNA replication stress	cell cycle arrest in response to pheromone|osmosensory signaling pathway	molecular_function	integral to membrane|plasma membrane|fungal-type vacuole|cytoplasm
YNL077W	YNL077W	APJ1	hom	Verified	1.91926909133095	0.0274751437835117	no	260	0.0479875815371212	228	NA	FT		NUCLEUS|MITOCHONDRION		Chaperone with a role in SUMO-mediated protein degradation; member of the DnaJ-like family; conserved across eukaryotes; overexpression interferes with propagation of the [Psi+] prion; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; forms nuclear foci upon DNA replication stress	biological_process	unfolded protein binding	mitochondrion|nucleus|cytoplasm
YCR028C	YCR028C	FEN2	hom	Verified	1.91335202512507	0.0278515008429823	no	261	0.0445896900173655	175	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION	PLASMA MEMBRANE		Plasma membrane H+-pantothenate symporter; confers sensitivity to the antifungal agent fenpropimorph; relocalizes from vacuole to cytoplasm upon DNA replication stress	pantothenate transmembrane transport|endocytosis	pantothenate transmembrane transporter activity	integral to membrane|plasma membrane
YDR516C	YDR516C	EMI2	hom	Verified	1.90995254949754	0.0280696615507218	no	262	0.0292121137582033	164	NA	FT	TRANSCRIPTION FROM RNA POL II|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY			Non-essential protein of unknown function; required for transcriptional induction of the early meiotic-specific transcription factor IME1; required for sporulation; expression regulated by glucose-repression transcription factors Mig1/2p; EMI2 has a paralog, GLK1, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress	ascospore formation|positive regulation of transcription from RNA polymerase II promoter	molecular_function	cytoplasm
YOL110W	YOL110W	SHR5	hom	Verified	1.90445291683731	0.0284256115387209	no	263	0.0279422966653753	161	NA	FT	PROTEIN LOCALIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Subunit of a palmitoyltransferase, composed of Shr5p and Erf2p, that adds a palmitoyl lipid moiety to heterolipidated substrates such as Ras1p and Ras2p through a thioester linkage; palmitoylation is required for Ras2p membrane localization	protein targeting to membrane|protein palmitoylation	palmitoyltransferase activity	endoplasmic reticulum palmitoyltransferase complex|extrinsic to endoplasmic reticulum membrane
YBR223C	YBR223C	TDP1	hom	Verified	1.89221307798266	0.0292312982935301	no	264	0.0332981382592125	170	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		Tyrosyl-DNA phosphodiesterase I; hydrolyzes 3' and 5'-phosphotyrosyl bonds; involved in the repair of DNA lesions created by topoisomerase I and topoisomerase II; mutations in human homolog result in the neurodegenerative disease SCANI	DNA repair	3'-tyrosyl-DNA phosphodiesterase activity|5'-tyrosyl-DNA phosphodiesterase activity	nucleus
YER005W	YER005W	YND1	hom	Verified	1.88726895229435	0.0295620800971946	no	265	0.0300554560049545	193	NA	FT	LIPID METABOLISM|CARBOHYDRATE METABOLISM	GOLGI APPARATUS		Apyrase with wide substrate specificity, helps prevent inhibition of glycosylation by hydrolyzing nucleoside tri- and diphosphates that inhibit glycotransferases; partially redundant with Gda1p; mediates adenovirus E4orf4-induced toxicity	protein glycosylation	nucleoside-triphosphatase activity|nucleoside-diphosphatase activity	COPI-coated vesicle|Golgi apparatus|membrane|Golgi membrane
YKL096W-A	YKL096W-A	CWP2	hom	Verified	1.88547863200402	0.029682623343928	no	266	0.0299910621522159	194	NA	FT	ION HOMEOSTASIS|CELL WALL ORG/BIOGENESIS|ION HOMEOSTASIS			Covalently linked cell wall mannoprotein, major constituent of the cell wall; plays a role in stabilizing the cell wall; involved in low pH resistance; precursor is GPI-anchored	fungal-type cell wall organization|regulation of pH	structural constituent of cell wall	fungal-type cell wall
YLR244C	YLR244C	MAP1	hom	Verified	1.88131341092533	0.0299646488896685	no	267	0.0392792501406863	181	NA	FT	PROTEOLYSIS		RIBOSOME	Methionine aminopeptidase, catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map2p	negative regulation of gene expression|protein initiator methionine removal involved in protein maturation	metalloaminopeptidase activity|mRNA binding	cytosolic ribosome
YPL029W	YPL029W	SUV3	hom	Verified	1.88102736054029	0.0299840985271644	no	268	0.072528402078633	318	NA	FF|FT	RNA PROCESSING|MITOCHONDRION ORGANIZATION	MITOCHONDRION|CHROMOSOME		ATP-dependent RNA helicase, component of the mitochondrial degradosome along with the RNase Dss1p; the degradosome associates with the ribosome and mediates RNA turnover; also required during splicing of the COX1 AI5_beta intron	mitochondrial DNA replication|mitochondrial RNA catabolic process|Group I intron splicing	exoribonuclease II activity|ATP-dependent RNA helicase activity	mitochondrion|mitochondrial chromosome|mitochondrial degradosome
YGR104C	YGR104C	SRB5	hom	Verified	1.87181187756776	0.0306163172243514	no	269	0.0349703678728806	213	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS	RNA POL II, HOLOENZYME	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; required for proper termination of transcription for some genes; involved in telomere maintenance	transcriptional open complex formation at RNA polymerase II promoter|RNA polymerase II transcriptional preinitiation complex assembly|positive regulation of transcription from RNA polymerase II promoter	core RNA polymerase II binding transcription factor activity|RNA polymerase II transcription factor recruiting transcription factor activity|TBP-class protein binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly	core mediator complex
YOL051W	YOL051W	GAL11	hom	Verified	1.86476014278902	0.0311075161808783	no	270	0.077073705480542	399	NA	FF|FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS	RNA POL II, HOLOENZYME	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; affects transcription by acting as target of activators and repressors; forms part of the tail domain of mediator	negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II transcriptional preinitiation complex assembly|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly|TFIIE-class binding transcription factor activity|RNA polymerase II activating transcription factor binding|TFIIE-class transcription factor binding|TFIIH-class transcription factor binding|RNA polymerase II transcription factor recruiting transcription factor activity	core mediator complex
YCL056C	YCL056C	PEX34	hom	Verified	1.85890798349786	0.03152009114841	no	271	0.0329941152791393	186	NA	FT	PEROXISOME ORGANIZATION			Peroxisomal integral membrane protein that regulates peroxisome populations; interacts with Pex11p, Pex25p, and Pex27p to control both constitutive peroxisome division and peroxisome morphology and abundance during peroxisome proliferation	peroxisome organization	molecular_function	integral to peroxisomal membrane|cytoplasm
YDR202C	YDR202C	RAV2	hom	Verified	1.85565291905179	0.0317515227944382	no	272	0.0493194632675894	249	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|ION HOMEOSTASIS			Subunit of RAVE (Rav1p, Rav2p, Skp1p), a complex that associates with the V1 domain of the vacuolar membrane (H+)-ATPase (V-ATPase) and promotes assembly and reassembly of the holoenzyme	vacuolar acidification|regulation of protein complex assembly	molecular_function	RAVE complex
YPR134W	YPR134W	MSS18	hom	Verified	1.84915445781766	0.0322177563623324	no	273	0.0340956362852709	229	NA	FT	RNA PROCESSING	MITOCHONDRION		Nuclear encoded protein needed for efficient splicing of mitochondrial COX1 aI5beta intron; mss18 mutations block cleavage of 5' exon - intron junction; phenotype of intronless strain suggests additional functions	Group I intron splicing	molecular_function	mitochondrion
YKR024C	YKR024C	DBP7	hom	Verified	1.84791846263784	0.0323070696108416	no	274	0.0314598984085119	231	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Putative ATP-dependent RNA helicase of the DEAD-box family involved in ribosomal biogenesis; essential for growth under anaerobic conditions	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	ATP-dependent RNA helicase activity	nucleolus
YJL175W_d	YJL175W	YJL175W	hom	Dubious	1.84669919149237	0.0323953744758466	no	275	0.0257761437335857	93	NA					Dubious open reading frame unlikely to encode a functional protein; deletion confers resistance to cisplatin, hypersensitivity to 5-fluorouracil, and growth defect at high pH with high calcium; overlaps gene for SWI3 transcription factor	Unknown	Unknown	Unknown
YKL084W	YKL084W	HOT13	hom	Verified	1.84643178353069	0.0324147679158121	no	276	0.0345076732131077	171	NA	FT	PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Zinc-binding mitochondrial intermembrane space (IMS) protein involved in a disulfide relay system for IMS import of cysteine-containing proteins; binds Mia40p and stimulates its Erv1p-dependent oxidation, probably by sequestering zinc	protein import into mitochondrial intermembrane space	zinc ion binding	mitochondrial intermembrane space
YNL035C	YNL035C	YNL035C	hom	Verified	1.8452941848148	0.0324973779744751	no	277	0.0230648266828226	144	NA	FT		NUCLEUS		Protein of unknown function; contains WD-40 domains; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YNL035C is not an essential gene; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	nucleus
YGL126W	YGL126W	SCS3	hom	Verified	1.83816130392857	0.0330193199786012	no	278	0.0379919551198894	181	NA	FT	LIPID METABOLISM	ENDOPLASMIC RETICULUM		Protein required for inositol prototrophy; required for normal ER membrane biosynthesis; ortholog of the FIT family of proteins involved in triglyceride droplet biosynthesis and homologous to human FIT2; disputed role in the synthesis of inositol phospholipids from inositol	phospholipid metabolic process	molecular_function	integral to membrane|endoplasmic reticulum
YDL156W	YDL156W	CMR1	hom	Verified	1.83677262463693	0.0331217344126175	no	279	0.0397095784626442	174	NA	FT		NUCLEUS|CHROMOSOME		DNA-binding protein with preference for UV-damaged DNA; protein sequence contains three WD domains (WD-40 repeat); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; potential regulatory target of Mbp1p, which binds to the promoter region; co-localizes with Hos2p in nuclear foci in response to DNA damage by MMS	biological_process	DNA binding	nuclear chromatin|nucleus|cytoplasm
YMR073C	YMR073C	IRC21	hom	Verified	1.8346994502112	0.0332751169035167	no	280	0.0914149927147977	390	NA	FF				Putative protein of unknown function; may be involved in resistance to carboplatin and cisplatin; null mutant displays increase in spontaneous Rad52p foci; contains a lipid-binding domain and binds cardiolipin in a large-scale study	response to drug	molecular_function	cytoplasm
YOR311C	YOR311C	DGK1	hom	Verified	1.83246682493053	0.0334409499974172	no	281	0.0221649992422497	126	NA	FT	VESICLE-MEDIATED TRANSPORT|KETONE METABOLISM|LIPID METABOLISM	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Diacylglycerol kinase, localized to the endoplasmic reticulum (ER); overproduction induces enlargement of ER-like membrane structures and suppresses a temperature-sensitive sly1 mutation; contains a CTP transferase domain	phosphatidic acid biosynthetic process	diacylglycerol kinase activity	integral to endoplasmic reticulum membrane|integral to membrane
YHR124W	YHR124W	NDT80	hom	Verified	1.83175876278751	0.033493684752836	no	282	0.0302198106614982	197	NA	FT	CELL CYCLE|CELL DIVISION	NUCLEUS|CHROMOSOME		Meiosis-specific transcription factor required for exit from pachytene and for full meiotic recombination; activates middle sporulation genes; competes with Sum1p for binding to promoters containing middle sporulation elements (MSE)	meiosis|transcription, DNA-dependent	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	nuclear chromosome
YJR051W	YJR051W	OSM1	hom	Verified	1.82838886494045	0.033745605667286	no	283	0.0281743987439017	164	NA	FT	OXIDATION-REDUCTION PROCESS	MITOCHONDRION		Fumarate reductase, catalyzes the reduction of fumarate to succinate; required for the reoxidation of intracellular NADH under anaerobic conditions; mutations cause osmotic sensitivity; OSM1 has a paralog, FRD1, that arose from the whole genome duplication	cellular response to anoxia	fumarate reductase (NADH) activity	mitochondrion
YOR135C_d	YOR135C	IRC14	hom	Dubious	1.82666113809314	0.0338753673819806	no	284	0.0246215860385995	172	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YOR136W; null mutant displays increased levels of spontaneous Rad52 foci	Unknown	Unknown	Unknown
YBR034C	YBR034C	HMT1	hom	Verified	1.82442135949801	0.0340441976412788	no	285	0.0441340759326965	199	NA	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RNA LOCALIZATION	NUCLEUS		Nuclear SAM-dependent mono- and asymmetric arginine dimethylating methyltransferase that modifies hnRNPs, including Npl3p and Hrp1p, affecting their activity and nuclear export; methylates U1 snRNP protein Snp1p and ribosomal protein Rps2p; interacts genetically with genes encoding components of Rpd3(L) and this interaction is important for Rpd3 recruitment to the subtelomeric region.	mRNA export from nucleus|negative regulation of DNA-dependent transcription, termination|positive regulation of transcription elongation from RNA polymerase II promoter|peptidyl-arginine methylation	protein-arginine omega-N asymmetric methyltransferase activity|protein-arginine omega-N monomethyltransferase activity	nucleus
YDL067C	YDL067C	COX9	hom	Verified	1.81612990982632	0.0346752232860633	no	286	0.0356483822443378	226	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Subunit VIIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain	mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity	mitochondrion|integral to membrane|mitochondrial respiratory chain complex IV
YGR026W_p	YGR026W	YGR026W	hom	Uncharacterized	1.81598135427051	0.0346866161984434	no	287	0.0359309555664863	163	NA	FT		PLASMA MEMBRANE		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery	biological_process	molecular_function	integral to membrane
YKL190W	YKL190W	CNB1	hom	Verified	1.81506889647903	0.0347566611803609	no	288	0.0380968732900029	248	NA	FF|FT	SIGNALING|ION HOMEOSTASIS|CELL WALL ORG/BIOGENESIS|ION HOMEOSTASIS			Calcineurin B; the regulatory subunit of calcineurin, a Ca++/calmodulin-regulated type 2B protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is encoded by CNA1 and/or CMP1; protein abundance increases in response to DNA replication stress	adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion|fungal-type cell wall organization|cellular ion homeostasis	calcium-dependent protein serine/threonine phosphatase activity|calcium ion binding	calcineurin complex
YGR224W	YGR224W	AZR1	hom	Verified	1.81302368839789	0.0349140839056779	no	289	0.0268368812927433	187	NA	FT		PLASMA MEMBRANE		Plasma membrane transporter of the major facilitator superfamily, involved in resistance to azole drugs such as ketoconazole and fluconazole	azole transport	azole transporter activity	integral to membrane|plasma membrane
YOR038C	YOR038C	HIR2	hom	Verified	1.80789507417641	0.035311416280604	no	290	0.0304352497581053	180	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION	NUCLEUS		Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; recruits Swi-Snf complexes to histone gene promoters; promotes heterochromatic gene silencing with Asf1p	DNA replication-independent nucleosome assembly|regulation of transcription from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter	nucleosome binding|transcription corepressor activity|DNA binding	HIR complex|nucleus
YER123W	YER123W	YCK3	hom	Verified	1.80394378634656	0.0356200599016016	no	291	0.0573127330165613	269	NA	FT	VESICLE-MEDIATED TRANSPORT|PROTEIN PHOSPHORYLATION	ENDOMEMBRANE SYSTEM|NUCLEUS|PLASMA MEMBRANE		Palmitoylated, vacuolar membrane-localized casein kinase I isoform; negatively regulates vacuole fusion during hypertonic stress via phosphorylation of Vps41p; shares essential functions with Hrr25p; regulates vesicle fusion in AP-3 pathway	vesicle-mediated transport|protein phosphorylation	protein serine/threonine kinase activity|protein kinase activity	fungal-type vacuole membrane|plasma membrane|nucleus|fungal-type vacuole
YKR085C	YKR085C	MRPL20	hom	Verified	1.80390215805638	0.0356233233107849	no	292	0.046197443433237	243	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YOR209C	YOR209C	NPT1	hom	Verified	1.80278568814095	0.0357109393482055	no	293	0.0673491236030695	333	NA	FF|FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|GENE SILENCING|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		Nicotinate phosphoribosyltransferase, acts in the salvage pathway of NAD+ biosynthesis; required for silencing at rDNA and telomeres and has a role in silencing at mating-type loci; localized to the nucleus	chromatin silencing at rDNA|replicative cell aging|nicotinate nucleotide salvage|chromatin silencing at telomere	nicotinate phosphoribosyltransferase activity	nucleus
YPL042C	YPL042C	SSN3	hom	Verified	1.79953337992024	0.0359671743162253	no	294	0.0646826908335306	293	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Cyclin-dependent protein kinase, component of RNA polymerase II holoenzyme; involved in phosphorylation of the RNA polymerase II C-terminal domain; involved in glucose repression	phosphorylation of RNA polymerase II C-terminal domain|negative regulation of transcription from RNA polymerase II promoter|negative regulation of filamentous growth|protein phosphorylation|protein destabilization|nuclear-transcribed mRNA catabolic process, non-stop decay|positive regulation of transcription from RNA polymerase II promoter by galactose	RNA polymerase II carboxy-terminal domain kinase activity|protein kinase activity|cyclin-dependent protein kinase activity	mediator complex
YDR049W	YDR049W	VMS1	hom	Verified	1.79715021940162	0.0361558874810773	no	295	0.0283435956638778	206	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION		Component of a Cdc48p-complex involved in protein quality control; exhibits cytosolic and ER-membrane localization, with Cdc48p, during normal growth, and contributes to ER-associated degradation (ERAD) of specific substrates at a step after their ubiquitination; forms a mitochondrially-associated complex with Cdc48p and Npl4p under oxidative stress that is required for ubiquitin-mediated mitochondria-associated protein degradation (MAD); conserved in C. elegans and humans	ER-associated protein catabolic process|mitochondria-associated protein catabolic process|nucleus-associated proteasomal ubiquitin-dependent protein catabolic process	molecular_function	cytosol|mitochondrion|endoplasmic reticulum membrane|Cdc48p-Npl4p-Vms1p AAA ATPase complex|cytoplasm
YMR086C-A_d	YMR086C-A	YMR086C-A	hom	Dubious	1.79626161492645	0.036226459779255	no	296	0.0331345829900668	203	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YER042W	YER042W	MXR1	hom	Verified	1.78450268220743	0.0371710096779339	no	297	0.0485328510886292	240	NA	FT	OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		Methionine-S-sulfoxide reductase, involved in the response to oxidative stress; protects iron-sulfur clusters from oxidative inactivation along with MXR2; involved in the regulation of lifespan	cellular response to oxidative stress	peptide-methionine-(S)-S-oxide reductase activity	nucleus|cytoplasm
YOR121C_d	YOR121C	YOR121C	hom	Dubious	1.78233667876194	0.0373471723837713	no	298	0.0329922747010172	191	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene GCY1/YOR120W	Unknown	Unknown	Unknown
YLR361C-A_p	YLR361C-A	YLR361C-A	hom	Uncharacterized	1.7823096401293	0.0373493757586619	no	299	0.0243925011068591	160	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YGR236C	YGR236C	SPG1	hom	Verified	1.78014498675156	0.0375261179359004	no	300	0.0351389604967369	167	NA	FT		MITOCHONDRION		Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YPR201W	YPR201W	ARR3	hom	Verified	1.77989931054491	0.0375462202810666	no	301	0.0299399922366561	201	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Plasma membrane metalloid/H+ antiporter; transports arsenite and antimonite; required for resistance to arsenic compounds; transcription is activated by Arr1p in the presence of arsenite	arsenite transport|antimonite transport	antiporter activity|arsenite transmembrane transporter activity|antimonite transmembrane transporter activity	integral to membrane|plasma membrane
YMR099C	YMR099C	YMR099C	hom	Verified	1.77915904312107	0.0376068455008868	no	302	0.0481403489425713	263	NA	FT	CARBOHYDRATE METABOLISM	NUCLEUS		Glucose-6-phosphate 1-epimerase (hexose-6-phosphate mutarotase), likely involved in carbohydrate metabolism; GFP-fusion protein localizes to both the nucleus and cytoplasm and is induced in response to the DNA-damaging agent MMS	cellular carbohydrate metabolic process	glucose-6-phosphate 1-epimerase activity	nucleus|cytoplasm
YMR040W	YMR040W	YET2	hom	Verified	1.77699703904897	0.0377843635003812	no	303	0.0426936424233109	115	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein of unknown function that may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein	biological_process	molecular_function	ribosome|integral to membrane
YAL067W-A_p	YAL067W-A	YAL067W-A	hom	Uncharacterized	1.77545752184592	0.0379111867200233	no	304	0.0333127484601883	186	NA					Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching	biological_process	molecular_function	cellular_component
YLR120C	YLR120C	YPS1	hom	Verified	1.7730272816208	0.0381120931615872	no	305	0.0512599406509974	189	NA	FT	CELL WALL ORG/BIOGENESIS|PROTEOLYSIS	PLASMA MEMBRANE		Aspartic protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor	fungal-type cell wall organization|protein processing	aspartic-type endopeptidase activity	fungal-type cell wall
YHL020C	YHL020C	OPI1	hom	Verified	1.77233562565585	0.0381694304066115	no	306	0.0478866319449608	254	NA	FT	TRANSCRIPTION FROM RNA POL II|LIPID METABOLISM|SIGNALING	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM		Transcriptional regulator of a variety of genes; phosphorylation by protein kinase A stimulates Opi1p function in negative regulation of phospholipid biosynthetic genes; involved in telomere maintenance	endoplasmic reticulum unfolded protein response|negative regulation of transcription from RNA polymerase II promoter|phospholipid biosynthetic process|positive regulation of transcription from RNA polymerase II promoter	transcription corepressor activity	nuclear membrane|nucleoplasm|nuclear envelope|endoplasmic reticulum|nucleus
YPR127W	YPR127W	YPR127W	hom	Verified	1.77033394482237	0.0383357632541209	no	307	0.0338287547149695	228	NA	FT	OXIDATION-REDUCTION PROCESS	NUCLEUS		Putative pyridoxine 4-dehydrogenase; differentially expressed during alcoholic fermentation; expression activated by transcription factor YRM1/YOR172W; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus	biological_process	molecular_function	nucleus|cytoplasm
YNL307C	YNL307C	MCK1	hom	Verified	1.76860194958736	0.0384801625951637	no	308	0.0547361015004577	281	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION|CHROMOSOME SEGREGATION			Protein serine/threonine/tyrosine (dual-specificity) kinase; involved in control of chromosome segregation and in regulating entry into meiosis; interacts with Clb2p and Mih1p; inhibits Clb2p-Cdk1 activity; related to mammalian glycogen synthase kinases of the GSK-3 family	meiosis|double-strand break repair via nonhomologous end joining|ascospore formation|protein phosphorylation|response to stress|mitotic sister chromatid segregation	protein serine/threonine/tyrosine kinase activity|protein serine/threonine kinase activity|protein kinase activity	cellular_component
YJL213W	YJL213W	YJL213W	hom	Verified	1.7679730430011	0.0385327051758329	no	309	0.0303060867849197	166	NA					Protein of unknown function that may interact with ribosomes; periodically expressed during the yeast metabolic cycle; phosphorylated in vitro by the mitotic exit network (MEN) kinase complex, Dbf2p/Mob1p	biological_process	molecular_function	ribosome
YJL182C_d	YJL182C	YJL182C	hom	Dubious	1.76575808147603	0.038718221940806	no	310	0.0373002849702174	211	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized ORF YJL181W	Unknown	Unknown	Unknown
YNL326C	YNL326C	PFA3	hom	Verified	1.76553012651026	0.0387373558098162	no	311	0.0433511538246619	212	NA	FT	MEMBRANE ORGANIZATION			Palmitoyltransferase for Vac8p, required for vacuolar membrane fusion; contains an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; autoacylates; required for vacuolar integrity under stress conditions	vacuole fusion, non-autophagic|protein palmitoylation	palmitoyltransferase activity	fungal-type vacuole membrane|integral to membrane|fungal-type vacuole
YIL141W_d	YIL141W	YIL141W	hom	Dubious	1.76467522779921	0.0388091821164123	no	312	0.0365905229107099	204	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YJL196C	YJL196C	ELO1	hom	Verified	1.76335262110367	0.0389205176977231	no	313	0.022646852704759	131	NA	FT	KETONE METABOLISM|LIPID METABOLISM			Elongase I, medium-chain acyl elongase; catalyzes carboxy-terminal elongation of unsaturated C12-C16 fatty acyl-CoAs to C16-C18 fatty acids; ELO1 has a paralog, FEN1, that arose from the whole genome duplication	fatty acid elongation, unsaturated fatty acid	fatty acid elongase activity	integral to membrane|membrane
YGR027C	YGR027C	RPS25A	hom	Verified	1.76093356313587	0.0391248241973389	no	314	0.0569014516569367	234	NA	FT	TRANSLATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S25, no bacterial homolog; RPS25A has a paralog, RPS25B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic small ribosomal subunit
YPL273W	YPL273W	SAM4	hom	Verified	1.75977027686654	0.0392233823162184	no	315	0.0311516875794528	193	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM	NUCLEUS		S-adenosylmethionine-homocysteine methyltransferase, functions along with Mht1p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio	homocysteine metabolic process|L-methionine biosynthetic process from S-adenosylmethionine|S-adenosylhomocysteine metabolic process	homocysteine S-methyltransferase activity	nucleus|cytoplasm
YLR377C	YLR377C	FBP1	hom	Verified	1.75082104652703	0.0399883700453296	no	316	0.0429204901188063	199	NA	FT	CARBOHYDRATE METABOLISM			Fructose-1,6-bisphosphatase, key regulatory enzyme in the gluconeogenesis pathway, required for glucose metabolism; undergoes either proteasome-mediated or autophagy-mediated degradation depending on growth conditions; interacts with Vid30p	gluconeogenesis|reactive oxygen species metabolic process	fructose 1,6-bisphosphate 1-phosphatase activity	cytosol
YPL088W_p	YPL088W	YPL088W	hom	Uncharacterized	1.74904263757635	0.0401418247451477	no	317	0.040218034733845	212	NA	FT	OXIDATION-REDUCTION PROCESS			Putative aryl alcohol dehydrogenase; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance	cellular aldehyde metabolic process	aryl-alcohol dehydrogenase (NAD+) activity	cellular_component
YBL080C	YBL080C	PET112	hom	Verified	1.74770448072846	0.0402576062722823	no	318	0.0636966604990615	308	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; mutation is functionally complemented by the bacterial GatB ortholog	glutaminyl-tRNAGln biosynthesis via transamidation|mitochondrial translation	glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity	mitochondrion|glutamyl-tRNA(Gln) amidotransferase complex
YGR239C	YGR239C	PEX21	hom	Verified	1.74267519296166	0.0406951836245927	no	319	0.0471692697240761	204	NA	FT	PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION			Peroxin required for peroxisomal matrix protein targeting; acts on proteins containing the PTS2 targeting sequence; interacts with Pex7p; partially redundant with Pex18p; relative distribution to cytoplasmic foci increases upon DNA replication stress	protein import into peroxisome matrix|positive regulation of protein binding	protein binding	cytosol|peroxisome
YLR279W_d	YLR279W	YLR279W	hom	Dubious	1.73987315105275	0.0409406470470436	no	320	0.0557372757418326	266	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDR469W	YDR469W	SDC1	hom	Verified	1.73097557169339	0.0417280607508215	no	321	0.0610409704862312	295	NA	FT	CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS		Subunit of the COMPASS (Set1C) complex, which methylates lysine 4 of histone H3 and is required in chromatin silencing at telomeres; contains a Dpy-30 domain that mediates interaction with Bre2p; similar to C. elegans and human DPY-30	histone H3-K4 methylation|chromatin silencing at telomere	histone methyltransferase activity (H3-K4 specific)	Set1C/COMPASS complex
YPL078C	YPL078C	ATP4	hom	Verified	1.72908427410973	0.0418970066298934	no	322	0.0446688580163354	222	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS	MITOCHONDRION		Subunit b of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; contributes to the oligomerization of the complex; phosphorylated	protein complex oligomerization|ATP synthesis coupled proton transport	proton-transporting ATPase activity, rotational mechanism	mitochondrion|mitochondrial proton-transporting ATP synthase, stator stalk|integral to membrane
YER073W	YER073W	ALD5	hom	Verified	1.72780867979041	0.0420112653636937	no	323	0.0467573449118082	214	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS	MITOCHONDRION		Mitochondrial aldehyde dehydrogenase, involved in regulation or biosynthesis of electron transport chain components and acetate formation; activated by K+; utilizes NADP+ as the preferred coenzyme; constitutively expressed	acetate biosynthetic process	aldehyde dehydrogenase [NAD(P)+] activity	mitochondrion
YHR013C	YHR013C	ARD1	hom	Verified	1.72703278020626	0.0420808882568063	no	324	0.0412670437998088	268	NA	FT	CHROMATIN ORGANIZATION		RIBOSOME	Subunit of protein N-terminal acetyltransferase NatA; NatA is comprised of Nat1p, Ard1p, and Nat5p; acetylates many proteins and thus affects telomeric silencing, cell cycle, heat-shock resistance, mating, and sporulation; human Ard1p levels are elevated in cancer cells; protein abundance increases in response to DNA replication stress	histone acetylation|N-terminal protein amino acid acetylation	peptide alpha-N-acetyltransferase activity	cytosolic ribosome|NatA complex
YNL148C	YNL148C	ALF1	hom	Verified	1.72617768608048	0.0421577255617055	no	325	0.0823220775993036	405	NA	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS	NUCLEUS|CYTOSKELETON		Alpha-tubulin folding protein, similar to mammalian cofactor B; Alf1p-GFP localizes to cytoplasmic microtubules; required for the folding of alpha-tubulin and may play an additional role in microtubule maintenance	protein folding|post-chaperonin tubulin folding pathway	microtubule binding|alpha-tubulin binding	nucleus|cytoplasm
YOR140W	YOR140W	SFL1	hom	Verified	1.72522077560612	0.0422438464910288	no	326	0.0401119279417013	217	NA	FT	TRANSCRIPTION FROM RNA POL II|GENE SILENCING	NUCLEUS		Transcriptional repressor and activator; involved in repression of flocculation-related genes, and activation of stress responsive genes; negatively regulated by cAMP-dependent protein kinase A subunit Tpk2p	gene silencing|Unknown|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II repressing transcription factor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity	nucleus
YML076C	YML076C	WAR1	hom	Verified	1.72368749699039	0.0423821366714059	no	327	0.029921822562601	164	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS|MITOCHONDRION		Homodimeric Zn2Cys6 zinc finger transcription factor; binds to a weak acid response element to induce transcription of PDR12 and FUN34, encoding an acid transporter and a putative ammonia transporter, respectively	response to acid	sequence-specific DNA binding transcription factor activity	mitochondrion|nucleus
YPL167C	YPL167C	REV3	hom	Verified	1.7163221586587	0.0430515474263636	no	328	0.0470307161717428	248	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS|MITOCHONDRION|CHROMOSOME		Catalytic subunit of DNA polymerase zeta, involved in translesion synthesis during post-replication repair; required for mutagenesis induced by DNA damage; involved in double-strand break repair	error-prone translesion synthesis|error-free translesion synthesis	DNA-directed DNA polymerase activity	nuclear chromatin|mitochondrion|zeta DNA polymerase complex
YGL167C	YGL167C	PMR1	hom	Verified	1.71280246504194	0.0433744432460541	no	329	0.0785533503184079	318	NA	FT	VESICLE-MEDIATED TRANSPORT|ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		High affinity Ca2+/Mn2+ P-type ATPase required for Ca2+ and Mn2+ transport into Golgi; involved in Ca2+ dependent protein sorting and processing; mutations in human homolog ATP2C1 cause acantholytic skin condition Hailey-Hailey disease	manganese ion transport|calcium ion transport|exocytosis	manganese-transporting ATPase activity|calcium-transporting ATPase activity|calcium ion binding	integral to membrane|Golgi membrane
YDR231C	YDR231C	COX20	hom	Verified	1.70749960556396	0.0438646155246325	no	330	0.0446329845747373	210	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase	mitochondrial respiratory chain complex IV assembly|protein processing|aerobic respiration	unfolded protein binding	mitochondrion|mitochondrial inner membrane
YPR006C	YPR006C	ICL2	hom	Verified	1.70730265306917	0.0438829066267434	no	331	0.0465028823124485	278	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		2-methylisocitrate lyase of the mitochondrial matrix, functions in the methylcitrate cycle to catalyze the conversion of 2-methylisocitrate to succinate and pyruvate; ICL2 transcription is repressed by glucose and induced by ethanol	threonine catabolic process|propionate metabolic process	methylisocitrate lyase activity	mitochondrion|mitochondrial matrix
YMR125W	YMR125W	STO1	hom	Verified	1.70133576177144	0.0444399781624999	no	332	0.0608451801471545	288	NA	FT	RNA PROCESSING|RNA LOCALIZATION	NUCLEUS		Large subunit of the nuclear mRNA cap-binding protein complex, interacts with Npl3p to carry nuclear poly(A)+ mRNA to cytoplasm; also involved in nuclear mRNA degradation and telomere maintenance; orthologous to mammalian CBP80	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|mRNA splicing, via spliceosome|response to osmotic stress	mRNA binding	commitment complex|nuclear cap binding complex|polysome
YPR148C	YPR148C	YPR148C	hom	Verified	1.70129906417514	0.044443421813529	no	333	0.0419644597505872	174	NA					Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern	biological_process	molecular_function	ribosome|cytoplasm
YOR193W	YOR193W	PEX27	hom	Verified	1.6997756264122	0.0445865689123447	no	334	0.0411625232171863	197	NA	FT	PEROXISOME ORGANIZATION			Peripheral peroxisomal membrane protein involved in controlling peroxisome size and number, interacts with homologous protein Pex25p	peroxisome organization	molecular_function	peroxisomal membrane
YPR071W_p	YPR071W	YPR071W	hom	Uncharacterized	1.68943556274316	0.0455679953380761	no	335	0.0477778035981694	232	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Putative membrane protein; YPR071W is not an essential gene; YPR071W has paralog YIL029C	biological_process	molecular_function	integral to membrane
YPL069C	YPL069C	BTS1	hom	Verified	1.68572092460311	0.0459247823192443	no	336	0.163943151498449	633	NA	FF|FT	PROTEIN LOCALIZATION|LIPID METABOLISM	MITOCHONDRION		Geranylgeranyl diphosphate synthase, increases the intracellular pool of geranylgeranyl diphosphate, suppressor of bet2 mutation that causes defective geranylgeranylation of small GTP-binding proteins that mediate vesicular traffic	terpenoid biosynthetic process	farnesyltranstransferase activity	mitochondrion
YLR356W	YLR356W	ATG33	hom	Verified	1.68531018872299	0.0459643704962943	no	337	0.0403457815907707	179	NA	FT		MITOCHONDRION		Mitochondrial mitophagy-specific protein; required primarily for mitophagy induced at the post-log phase; not required for other types of selective autophagy or macroautophagy; conserved within fungi, but not in higher eukaryotes	mitochondrion degradation	molecular_function	mitochondrion|integral to membrane
YHR176W	YHR176W	FMO1	hom	Verified	1.68486114344492	0.0460076824366556	no	338	0.0446801035403259	241	NA	FT	OXIDATION-REDUCTION PROCESS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Flavin-containing monooxygenase, localized to the cytoplasmic face of the ER membrane; catalyzes oxidation of biological thiols to maintain the ER redox buffer ratio for correct folding of disulfide-bonded proteins	protein folding	N,N-dimethylaniline monooxygenase activity	endoplasmic reticulum membrane
YJR074W	YJR074W	MOG1	hom	Verified	1.68045351357305	0.0464345558385351	no	339	0.0508991484660145	275	NA	FT	PROTEIN LOCALIZATION|RNA LOCALIZATION	NUCLEUS		Conserved nuclear protein that interacts with GTP-Gsp1p, which is a Ran homolog of the Ras GTPase family, and stimulates nucleotide release, involved in nuclear protein import, nucleotide release is inhibited by Yrb1p	protein import into nucleus	Ran GTPase binding	nucleus
YMR237W	YMR237W	BCH1	hom	Verified	1.6741815993824	0.0470474573318557	no	340	0.0532685993613905	276	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	GOLGI APPARATUS		Member of the ChAPs family (Chs5p-Arf1p-binding proteins); members include Bch1p, Bch2p, Bud7p, and Chs6p; ChAPs family proteins form the exomer complex with Chs5p to mediate export of specific cargo proteins from the Golgi to the plasma membrane; may interact with ribosomes; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress; BCH1 has a paralog, BUD7, that arose from the whole genome duplication	Golgi to plasma membrane transport|fungal-type cell wall chitin biosynthetic process	molecular_function	ribosome|clathrin-coated vesicle|exomer complex
YHR143W	YHR143W	DSE2	hom	Verified	1.673862131034	0.0470788490804495	no	341	0.0800324549316247	353	NA	FF|FT	CELL WALL ORG/BIOGENESIS|CELL DIVISION			Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother; expression is repressed by cAMP	cytokinesis, completion of separation|pseudohyphal growth	glucosidase activity	extracellular region|fungal-type cell wall
YDR532C	YDR532C	KRE28	hom	Verified	1.67366228251622	0.0470984952262345	no	342	0.0675145532092509	214	NA	FT		ENDOMEMBRANE SYSTEM|NUCLEUS|CHROMOSOME|CYTOSKELETON	KINETOCHORE	Subunit of a kinetochore-microtubule binding complex with Spc105p that bridges centromeric heterochromatin and kinetochore MAPs and motors, and is also required for sister chromatid bi-orientation and kinetochore binding of SAC components	biological_process	molecular_function	chromosome, centromeric region|condensed nuclear chromosome kinetochore|spindle pole body
YJL027C_p	YJL027C	YJL027C	hom	Uncharacterized	1.67159209776009	0.0473023920429885	no	343	0.0400610543738291	207	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YPL148C	YPL148C	PPT2	hom	Verified	1.67145578758338	0.0473158423014548	no	344	0.0935114550930341	387	NA	FF|FT	KETONE METABOLISM|LIPID METABOLISM	MITOCHONDRION		Phosphopantetheine:protein transferase (PPTase), activates mitochondrial acyl carrier protein (Acp1p) by phosphopantetheinylation	protein-cofactor linkage	holo-[acyl-carrier-protein] synthase activity	mitochondrion
YNL072W	YNL072W	RNH201	hom	Verified	1.66772826551594	0.0476848408464372	no	345	0.115312813553866	451	NA	FT		NUCLEUS		Ribonuclease H2 catalytic subunit, removes RNA primers during Okazaki fragment synthesis and errant ribonucleotides misincorporated during DNA replication; homolog of RNAse HI; related to human AGS4 which causes Aicardi-Goutieres syndrome	DNA replication, removal of RNA primer	ribonuclease H activity	ribonuclease H2 complex|nucleus
YOL155C	YOL155C	HPF1	hom	Verified	1.6667452219983	0.0477825383247286	no	346	0.0543523566385437	288	NA	FT	CELL WALL ORG/BIOGENESIS			Haze-protective mannoprotein that reduces the particle size of aggregated proteins in white wines	fungal-type cell wall organization	glucosidase activity	fungal-type cell wall|extracellular region
YOR291W	YOR291W	YPK9	hom	Verified	1.66465551071232	0.0479907518525469	no	347	0.0358354807597696	136	NA	FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS			Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome	biological_process	molecular_function	fungal-type vacuole membrane|integral to membrane
YPL055C	YPL055C	LGE1	hom	Verified	1.66408380995088	0.0480478409989421	no	348	0.0649255001223322	331	NA	FT	CHROMATIN ORGANIZATION	NUCLEUS		Protein of unknown function; null mutant forms abnormally large cells, and homozygous diploid null mutant displays delayed premeiotic DNA synthesis and reduced efficiency of meiotic nuclear division	histone methylation|protein monoubiquitination|regulation of cell size|histone ubiquitination|premeiotic DNA replication	molecular_function	nucleus
YDL117W	YDL117W	CYK3	hom	Verified	1.66076900278352	0.0483799244271601	no	349	0.0488815605632715	234	NA	FT	CELL CYCLE|CELL DIVISION	SITE OF POLARIZED GROWTH|CYTOSKELETON		SH3-domain protein located in the bud neck and cytokinetic actin ring; relocalizes from bud neck to nucleus upon DNA replication stress; activates the chitin synthase activity of Chs2p during cytokinesis; suppressor of growth and cytokinesis defects of chs2 phospho-mutants	barrier septum assembly involved in cell cycle cytokinesis|cytokinesis	molecular_function	cellular bud neck contractile ring|cellular bud neck|cytoplasm
YJL003W	YJL003W	COX16	hom	Verified	1.65773538779443	0.048685443884985	no	350	0.047752293403566	202	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial inner membrane protein, required for assembly of cytochrome c oxidase	mitochondrial respiratory chain complex IV assembly	molecular_function	mitochondrion|mitochondrial inner membrane
YGR263C	YGR263C	SAY1	hom	Verified	1.65701136746639	0.0487585884421278	no	351	0.0527581528927577	201	NA	FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Sterol deacetylase; component of the sterol acetylation/deacetylation cycle along with Atf2p; integral membrane protein with active site in the ER lumen; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum	response to toxin|sterol metabolic process|sterol deacetylation	steryl deacetylase activity	integral to membrane|endoplasmic reticulum|endoplasmic reticulum lumen
YGL188C-A_p	YGL188C-A	YGL188C-A	hom	Uncharacterized	1.6560207161367	0.0488588118201791	no	352	0.0676627115759003	332	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YLR124W_d	YLR124W	YLR124W	hom	Dubious	1.65422359050678	0.0490410456833904	no	353	0.0511752321879262	230	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YNL334C	YNL334C	SNO2	hom	Verified	1.65355518427169	0.0491089624252984	no	354	0.0513075140779502	246	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Protein of unknown function, nearly identical to Sno3p; expression is induced before the diauxic shift and also in the absence of thiamin	pyridoxine metabolic process|thiamine biosynthetic process	molecular_function	cellular_component
YBR081C	YBR081C	SPT7	hom	Verified	1.65110810948544	0.0493582508574785	no	355	0.0848941184179516	349	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CHROMATIN ORGANIZATION	NUCLEUS|MITOCHONDRION	HISTONE ACETYLTRANSFERASE	Subunit of the SAGA transcriptional regulatory complex, involved in proper assembly of the complex; also present as a C-terminally truncated form in the SLIK/SALSA transcriptional regulatory complex	conjugation with cellular fusion|histone acetylation|protein complex assembly|chromatin modification	structural molecule activity	SLIK (SAGA-like) complex|mitochondrion|SAGA complex
YGL100W	YGL100W	SEH1	hom	Verified	1.65025599570544	0.0494452941806422	no	356	0.0661724766495989	336	NA	FF|FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS|PLASMA MEMBRANE	NUCLEAR PORE	Component of two distinct complexes; subunit of the Nup84 nuclear pore sub-complex (NPC) and the Seh1-associated (SEA) complex; the the NUP84 subcomplex contributes to nucleocytoplasmic transport and NPC biogenesis; the SEA complex is a coatamer-related complex that associates dynamically with the vacuole; homologous to human SEH1	nucleocytoplasmic transport	structural constituent of nuclear pore	fungal-type vacuole membrane|integral to membrane|nuclear pore|Seh1-associated complex|nuclear pore outer ring
YPL096C-A	YPL096C-A	ERI1	hom	Verified	1.6481553376785	0.0496603995586427	no	357	0.076477888061342	380	NA	FT	LIPID METABOLISM|SIGNALING	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Endoplasmic reticulum membrane protein that binds to and inhibits GTP-bound Ras2p at the ER; component of the GPI-GnT complex which catalyzes the first step in GPI-anchor biosynthesis; probable homolog of mammalian PIG-Y protein	GPI anchor biosynthetic process|Ras protein signal transduction	GTPase inhibitor activity	glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex|endoplasmic reticulum membrane
YLR143W	YLR143W	DPH6	hom	Verified	1.64293867762253	0.0501978107742912	no	358	0.0719609269223332	281	NA					Diphthamide synthetase; catalyzes the last amidation step of diphthamide biosynthesis using ammonium and ATP; evolutionarily conserved in eukaryotes; dph6 mutants exhibit diphthine accumulation and resistance to sordarin, which is indicative of defects in diphthamide formation on EF2; green fluorescent protein (GFP)-tagged protein localizes to the cytoplasm; DPH6/YLR143W is not an essential gene	biological_process	molecular_function	cytoplasm
YOL023W	YOL023W	IFM1	hom	Verified	1.63919603644871	0.0505862195214502	no	359	0.0700160866057	343	NA	FT	TRANSLATION|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial translation initiation factor 2	translational initiation|mitochondrial translational initiation|mitochondrial translation	tRNA binding|GTPase activity|translation initiation factor activity	mitochondrion
YLR345W_p	YLR345W	YLR345W	hom	Uncharacterized	1.63701343715663	0.0508138309735789	no	360	0.0538448893582246	236	NA	FT	CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY			Similar to 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase enzymes responsible for the metabolism of fructoso-2,6-bisphosphate; mRNA expression is repressed by the Rfx1p-Tup1p-Ssn6p repressor complex; YLR345W is not an essential gene	regulation of glycolysis|fructose 2,6-bisphosphate metabolic process	6-phosphofructo-2-kinase activity	cytoplasm
YOR386W	YOR386W	PHR1	hom	Verified	1.63499296187245	0.0510252615222467	no	361	0.0590154554398247	293	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS|MITOCHONDRION		DNA photolyase involved in photoreactivation, repairs pyrimidine dimers in the presence of visible light; induced by DNA damage; regulated by transcriptional repressor Rph1p	photoreactive repair	mRNA binding|deoxyribodipyrimidine photo-lyase activity	mitochondrion|nucleus
YBR069C	YBR069C	TAT1	hom	Verified	1.63296056724191	0.0512386451720713	no	362	0.21234651252375	712	NA	FF|FT		PLASMA MEMBRANE		Amino acid transporter for valine, leucine, isoleucine, and tyrosine; low-affinity tryptophan and histidine transporter; overexpression confers FK506 and FTY720 resistance; protein abundance increases in response to DNA replication stress	amino acid transport|tyrosine transport|tryptophan transport|transmembrane transport	amino acid transmembrane transporter activity|low-affinity tryptophan transmembrane transporter activity	integral to membrane|plasma membrane
YML112W	YML112W	CTK3	hom	Verified	1.63044338185451	0.0515039111161624	no	363	0.105249179336624	405	NA	FF|FT	RNA PROCESSING|RESPONSE TO DNA DAMAGE|TRANSLATION|PROTEIN PHOSPHORYLATION	NUCLEUS		Gamma subunit of C-terminal domain kinase I; CTDK-I phosphorylates RNA polymerase II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and also phosphorylates ribosomal protein Rps2p to increase translational fidelity; protein abundance increases in response to DNA replication stress	mRNA 3'-end processing|positive regulation of translational fidelity|positive regulation of transcription from RNA polymerase I promoter|positive regulation of DNA-dependent transcription, elongation|protein phosphorylation	cyclin-dependent protein kinase activity	nucleoplasm|nucleolus|carboxy-terminal domain protein kinase complex
YPL096W	YPL096W	PNG1	hom	Verified	1.62924639053919	0.0516304349676001	no	364	0.0574794105612609	224	NA	FT	RESPONSE TO DNA DAMAGE|PROTEOLYSIS	NUCLEUS|MITOCHONDRION		Conserved peptide N-glycanase required for deglycosylation of misfolded glycoproteins during proteasome-dependent degradation; localizes to the cytoplasm and nucleus; activity is enhanced by interaction with Rad23p	misfolded or incompletely synthesized protein catabolic process|protein deglycosylation	peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity	cytosol|mitochondrion|nucleus
YPL248C	YPL248C	GAL4	hom	Verified	1.62832872058713	0.0517276013577037	no	365	0.0420842737414063	218	NA	FT	TRANSCRIPTION FROM RNA POL II|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		DNA-binding transcription factor required for the activation of the GAL genes in response to galactose; repressed by Gal80p and activated by Gal3p	galactose metabolic process|positive regulation of transcription from RNA polymerase II promoter by galactose	RNA polymerase II transcription factor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity	nucleus
YKL147C_d	YKL147C	YKL147C	hom	Dubious	1.62754614792385	0.0518105779163948	no	366	0.0226750586533205	138	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene AVT3	Unknown	Unknown	Unknown
YCR069W	YCR069W	CPR4	hom	Verified	1.62743205580778	0.0518226839895113	no	367	0.0459857556408164	227	NA					Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; has a potential role in the secretory pathway	biological_process	peptidyl-prolyl cis-trans isomerase activity	membrane
YER173W	YER173W	RAD24	hom	Verified	1.62639881258065	0.0519324216402085	no	368	0.0575891911835016	218	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Checkpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints; subunit of a clamp loader that loads Rad17p-Mec3p-Ddc1p onto DNA; homolog of human and S. pombe Rad17 protein	reciprocal meiotic recombination|DNA damage checkpoint|nucleotide-excision repair	DNA clamp loader activity	Rad17 RFC-like complex|nucleus
YBR045C	YBR045C	GIP1	hom	Verified	1.62516164713264	0.0520640600713929	no	369	0.0627005932958877	313	NA	FT	CELL WALL ORG/BIOGENESIS			Meiosis-specific regulatory subunit of the Glc7p protein phosphatase, regulates spore wall formation and septin organization, required for expression of some late meiotic genes and for normal localization of Glc7p	ascospore wall assembly|regulation of phosphoprotein phosphatase activity	protein phosphatase type 1 regulator activity|protein phosphatase 1 binding	protein phosphatase type 1 complex|prospore membrane
YDR533C	YDR533C	HSP31	hom	Verified	1.6234915015718	0.0522421893036781	no	370	0.0755799540308494	310	NA	FT	PROTEOLYSIS			Possible chaperone and cysteine protease; has similarity to E. coli Hsp31; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease; exists as a dimer and contains a putative metal-binding site; protein abundance increases in response to DNA replication stress	biological_process	unfolded protein binding|cysteine-type peptidase activity	cellular_component
YAL065C_p	YAL065C	YAL065C	hom	Uncharacterized	1.62253242556927	0.0523446980306439	no	371	0.0485092067701509	204	NA					Putative protein of unknown function; has homology to FLO1; possible pseudogene	biological_process	molecular_function	cellular_component
YLR035C	YLR035C	MLH2	hom	Verified	1.62010885696657	0.0526044475856095	no	372	0.0477342420313828	240	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS		Protein involved in the mismatch repair of certain frameshift intermediates and involved in meiotic recombination; forms a complex with Mlh1p	mismatch repair|reciprocal meiotic recombination	molecular_function	nucleus
YML013W	YML013W	UBX2	hom	Verified	1.61747500234481	0.0528878936815362	no	373	0.088963226655508	440	NA	FF|FT	PROTEOLYSIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION	UBIQUITIN LIGASE COMPLEX	Bridging factor involved in ER-associated protein degradation (ERAD); bridges the cytosolic Cdc48p-Npl1p-Ufd1p ATPase complex and the membrane associated Ssm4p and Hrd1p ubiquitin ligase complexes; contains a UBX (ubiquitin regulatory X) domain and a ubiquitin-associated (UBA) domain; redistributes from the ER to lipid droplets during the diauxic shift and stationary phase; required for the maintenance of lipid homeostasis	proteasomal ubiquitin-dependent protein catabolic process|ER-associated protein catabolic process|lipid particle organization	protein binding, bridging	mitochondrial outer membrane|Doa10p ubiquitin ligase complex|integral to endoplasmic reticulum membrane|lipid particle|endoplasmic reticulum
YLL054C_p	YLL054C	YLL054C	hom	Uncharacterized	1.61553360451301	0.053097594567555	no	374	0.0584682154309813	221	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Putative protein of unknown function with similarity to Pip2p, an oleate-specific transcriptional activator of peroxisome proliferation; YLL054C is not an essential gene	biological_process	sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity	cellular_component
YMR030W	YMR030W	RSF1	hom	Verified	1.61489565794743	0.0531666463620894	no	375	0.0420660807522536	168	NA	FT	TRANSCRIPTION FROM RNA POL II|SIGNALING|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS|MITOCHONDRION		Protein required for respiratory growth; localized to both the nucleus and mitochondrion; may interact with transcription factors to mediate the transition to respiratory growth and activate transcription of nuclear and mitochondrial genes	transcription from mitochondrial promoter|calcium-mediated signaling|transcription from RNA polymerase II promoter|aerobic respiration	molecular_function	mitochondrion|nucleus
YOR099W	YOR099W	KTR1	hom	Verified	1.61308165110319	0.0533633848554557	no	376	0.041034459051784	217	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Alpha-1,2-mannosyltransferase; involved in O- and N-linked protein glycosylation; type II membrane protein; member of the KRE2/MNT1 mannosyltransferase family; relocalizes from vacuole to cytoplasm upon DNA replication stress	N-glycan processing|cell wall mannoprotein biosynthetic process|protein O-linked glycosylation	alpha-1,2-mannosyltransferase activity	Golgi apparatus
YDR200C	YDR200C	VPS64	hom	Verified	1.61303460051713	0.0533684954028996	no	377	0.0777483128381681	313	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|SIGNALING|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein required for cytoplasm to vacuole targeting of proteins; forms a complex with Far3p and Far7p to Far11p involved in recovery from pheromone-induced cell cycle arrest; mutant has increased aneuploidy tolerance	re-entry into mitotic cell cycle after pheromone arrest|protein targeting to vacuole	molecular_function	endoplasmic reticulum membrane|cytoplasm
YLR386W	YLR386W	VAC14	hom	Verified	1.61166620895479	0.0535172973138589	no	378	0.0837319332666277	368	NA	FT	PROTEIN LOCALIZATION|LIPID METABOLISM			Protein involved in regulated synthesis of PtdIns(3,5)P(2), in control of trafficking of some proteins to the vacuole lumen via the MVB, and in maintenance of vacuole size and acidity; interacts with Fig4p; activator of Fab1p	phosphatidylinositol biosynthetic process|positive regulation of kinase activity	protein binding, bridging	fungal-type vacuole membrane|PAS complex|extrinsic to vacuolar membrane
YER016W	YER016W	BIM1	hom	Verified	1.60896627345997	0.0538118582552003	no	379	0.0488392421446411	267	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION	CHROMOSOME|CYTOSKELETON	KINETOCHORE	Microtubule-binding protein that together with Kar9p makes up the cortical microtubule capture site and delays the exit from mitosis when the spindle is oriented abnormally	nuclear migration along microtubule|microtubule nucleation|microtubule depolymerization|negative regulation of microtubule depolymerization|positive regulation of microtubule polymerization|mitotic sister chromatid cohesion|mitotic cell cycle spindle assembly checkpoint	microtubule plus-end binding|protein homodimerization activity|structural constituent of cytoskeleton	spindle midzone|microtubule plus end|cytoplasmic microtubule|spindle pole body|kinetochore|spindle pole|spindle
YKL204W	YKL204W	EAP1	hom	Verified	1.60883450192138	0.0538262672246913	no	380	0.07609806644161	324	NA	FT	TRANSLATION			eIF4E-associated protein, competes with eIF4G for binding to eIF4E; accelerates mRNA degradation by promoting decapping, facilitated by interaction with eIF4E; essential for Puf5p mediated repression; associates with Puf5p and Dhh1p; inhibits cap-dependent translation; functions independently of eIF4E to maintain genetic stability; plays a role in cell growth, implicated in the TOR signaling cascade	negative regulation of translation	eukaryotic initiation factor 4E binding	mRNA cap binding complex|cytoplasmic stress granule
YLR406C-A_p	YLR406C-A	YLR406C-A	hom	Uncharacterized	1.60787411400639	0.0539313761313355	no	381	0.0570473984767493	221	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YLR081W	YLR081W	GAL2	hom	Verified	1.6076338350222	0.0539576986746345	no	382	0.045002240105391	216	NA	FT	CARBOHYDRATE METABOLISM	PLASMA MEMBRANE		Galactose permease, required for utilization of galactose; also able to transport glucose	galactose transport|galactose metabolic process	galactose transmembrane transporter activity|glucose transmembrane transporter activity	integral to membrane|plasma membrane
YLR233C	YLR233C	EST1	hom	Verified	1.60422238545854	0.0543325210532677	no	383	0.0442496578642919	171	NA	FT		NUCLEUS|CHROMOSOME		TLC1 RNA-associated factor involved in telomere length regulation as recruitment subunit of telomerase; has G-quadruplex promoting activity that is required for telomere elongation; possible role in activating telomere-bound Est2p-TLC1-RNA	telomere maintenance via telomerase|telomere maintenance|G-quadruplex DNA formation	single-stranded DNA binding|RNA binding|telomeric DNA binding	nucleolus|nucleus|telomerase holoenzyme complex
YJL216C	YJL216C	IMA5	hom	Verified	1.60008919803594	0.0547893984849538	no	384	0.0708915391753698	306	NA	FT	CARBOHYDRATE METABOLISM			Alpha-glucosidase; specificity for isomaltose, maltose, and palatinose, but not alpha-methylglucoside; member of the IMA isomaltase family; not required for isomaltose utilization, but Ima5p overexpression allows the ima1 null mutant to grow on isomaltose	disaccharide catabolic process	oligo-1,6-glucosidase activity	cellular_component
YER096W	YER096W	SHC1	hom	Verified	1.59969909996099	0.0548326758181174	no	385	0.0591758015181028	294	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM			Sporulation-specific activator of Chs3p (chitin synthase III); required for the synthesis of the chitosan layer of ascospores; transcriptionally induced at alkaline pH; SHC1 has a paralog, SKT5, that arose from the whole genome duplication	ascospore formation|chitin biosynthetic process	enzyme activator activity	prospore membrane
YKL188C	YKL188C	PXA2	hom	Verified	1.59693742364677	0.0551398283474414	no	386	0.046003566231727	220	NA	FT	NUCLEOTIDE METABOLISM			Subunit of a heterodimeric peroxisomal ATP-binding cassette transporter complex (Pxa1p-Pxa2p), required for import of long-chain fatty acids into peroxisomes; similarity to human adrenoleukodystrophy transporter ABCD1 and ABCD2 and ALD-related proteins; mutations in ABCD1 cause X-linked adrenoleukodystrophy (X-ALD), a peroxisomal disorder	fatty acid transport	ATPase activity, coupled to transmembrane movement of substances	integral to membrane|integral to peroxisomal membrane
YDR182W-A_p	YDR182W-A	YDR182W-A	hom	Uncharacterized	1.596564524962	0.055181405940715	no	387	0.0645470667476921	251	NA					Putative protein of unknown function; identified by fungal homology and RT-PCR	biological_process	molecular_function	cellular_component
YNL096C	YNL096C	RPS7B	hom	Verified	1.59447532554418	0.0554148064845406	no	388	0.0660488431517988	316	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION	NUCLEUS	RIBOSOME	Protein component of the small (40S) ribosomal subunit; interacts with Kti11p; deletion causes hypersensitivity to zymocin; homologous to mammalian ribosomal protein S7, no bacterial homolog; RPS7B has a paralog, RPS7A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress	cytoplasmic translation|ribosome biogenesis	structural constituent of ribosome	small-subunit processome|cytosolic small ribosomal subunit
YPR179C	YPR179C	HDA3	hom	Verified	1.59260243206719	0.0556247038007156	no	389	0.0547678414753107	283	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|CHROMOSOME SEGREGATION|GENE SILENCING	NUCLEUS|CHROMOSOME		Subunit of a possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex that contains an Hda1p homodimer and an Hda2p-Hda3p heterodimer; required for the activity of the complex; has similarity to Hda2p	negative regulation of transcription from RNA polymerase II promoter|chromosome segregation|gene silencing by RNA|gene silencing involved in chronological cell aging|histone deacetylation	histone deacetylase activity|chromatin binding|DNA binding	nucleus|HDA1 complex
YER174C	YER174C	GRX4	hom	Verified	1.58936171583082	0.0559893763413652	no	390	0.0566160476920071	274	NA	FT	ION HOMEOSTASIS|CYTOSKELETON ORGANIZATION|ION HOMEOSTASIS|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx3p and Grx5p; protects cells from oxidative damage; mutant has increased aneuploidy tolerance; transcription is regulated by Yap5	cellular iron ion homeostasis|cellular response to oxidative stress|actin cytoskeleton organization	disulfide oxidoreductase activity	nucleus
YEL067C_p	YEL067C	YEL067C	hom	Uncharacterized	1.5890822021918	0.0560209176901097	no	391	0.0586661960930528	231	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YLR448W	YLR448W	RPL6B	hom	Verified	1.58825233761207	0.0561146452423879	no	392	0.0654656764650277	319	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L6B; binds 5.8S rRNA; homologous to mammalian ribosomal protein L6, no bacterial homolog; RPL6B has a paralog, RPL6A, that arose from the whole genome duplication	cytoplasmic translation|ribosomal large subunit assembly	structural constituent of ribosome|RNA binding	cytosolic large ribosomal subunit
YKL006W	YKL006W	RPL14A	hom	Verified	1.58546472918817	0.0564303922446938	no	393	0.0736621345296057	338	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L14A; N-terminally acetylated; homologous to mammalian ribosomal protein L14, no bacterial homolog; RPL14A has a paralog, RPL14B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome|RNA binding	cytosolic large ribosomal subunit
YLL009C	YLL009C	COX17	hom	Verified	1.58263950887198	0.0567518265032913	no	394	0.0475110804126672	194	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS	MITOCHONDRION		Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs	mitochondrial respiratory chain complex IV assembly|intracellular copper ion transport	copper chaperone activity	cytosol|mitochondrion|mitochondrial intermembrane space
YDR125C	YDR125C	ECM18	hom	Verified	1.57804771674792	0.0572773240295582	no	395	0.0824085589180223	319	NA	FT	CELL WALL ORG/BIOGENESIS	MITOCHONDRION		Protein of unknown function; ECM18 has a paralog, ICT1, that arose from the whole genome duplication	fungal-type cell wall organization	molecular_function	mitochondrion
YNL268W	YNL268W	LYP1	hom	Verified	1.57739143156307	0.0573527428908639	no	396	0.061204388719729	312	NA	FT		MITOCHONDRION|PLASMA MEMBRANE		Lysine permease; one of three amino acid permeases (Alp1p, Can1p, Lyp1p) responsible for uptake of cationic amino acids	basic amino acid transport	basic amino acid transmembrane transporter activity	mitochondrion|integral to membrane|plasma membrane
YLR209C	YLR209C	PNP1	hom	Verified	1.57629514871688	0.0574788995758384	no	397	0.0646541257093807	215	NA	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM			Purine nucleoside phosphorylase, specifically metabolizes inosine and guanosine nucleosides; involved in the nicotinamide riboside salvage pathway	guanosine catabolic process|inosine catabolic process|NAD biosynthesis via nicotinamide riboside salvage pathway|nicotinate nucleotide salvage	nicotinamide riboside hydrolase activity|inosine nucleosidase activity|purine-nucleoside phosphorylase activity	intracellular
YOL052C	YOL052C	SPE2	hom	Verified	1.57568611808428	0.0575490791159906	no	398	0.0679624233570241	219	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM	NUCLEUS		S-adenosylmethionine decarboxylase, required for the biosynthesis of spermidine and spermine; cells lacking Spe2p require spermine or spermidine for growth in the presence of oxygen but not when grown anaerobically	spermidine biosynthetic process|spermine biosynthetic process|pantothenate biosynthetic process	adenosylmethionine decarboxylase activity	nucleus|cytoplasm
YLR173W_p	YLR173W	YLR173W	hom	Uncharacterized	1.57501093123227	0.0576269606967927	no	399	0.058178951242264	237	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YDR541C_p	YDR541C	YDR541C	hom	Uncharacterized	1.57420865998658	0.0577196089653471	no	400	0.063718112697018	297	NA	FT	OXIDATION-REDUCTION PROCESS			Putative dihydrokaempferol 4-reductase	biological_process	carbonyl reductase (NADPH) activity	cellular_component
YKL221W	YKL221W	MCH2	hom	Verified	1.57411536579897	0.0577303904066053	no	401	0.0677113628386746	213	NA					Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport	transport	monocarboxylic acid transmembrane transporter activity|transporter activity	integral to membrane|membrane
YAL040C	YAL040C	CLN3	hom	Verified	1.57233999516573	0.0579358611140172	no	402	0.0539567245245203	293	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|MEMBRANE ORGANIZATION|CELL DIVISION|PROTEIN PHOSPHORYLATION	NUCLEUS		G1 cyclin involved in cell cycle progression; activates Cdc28p kinase to promote the G1 to S phase transition; plays a role in regulating transcription of the other G1 cyclins, CLN1 and CLN2; regulated by phosphorylation and proteolysis	vacuole organization|regulation of cyclin-dependent protein kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|vacuole fusion, non-autophagic|regulation of cell size|G1/S transition of mitotic cell cycle	cyclin-dependent protein kinase regulator activity	nucleus
YMR136W	YMR136W	GAT2	hom	Verified	1.57126491939288	0.0580605630627217	no	403	0.0573068264713674	227	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Protein containing GATA family zinc finger motifs; similar to Gln3p and Dal80p; expression repressed by leucine	regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding RNA polymerase II transcription factor activity	nucleus
YFL056C	YFL056C	AAD6	hom	Verified	1.56966945995136	0.058246014870186	no	404	0.0550386535234558	259	NA	FT	OXIDATION-REDUCTION PROCESS			Putative aryl-alcohol dehydrogenase; involved in oxidative stress response; similar to P. chrysosporium aryl-alcohol dehydrogenase; expression induced in cells treated with the mycotoxin patulin	cellular aldehyde metabolic process	aryl-alcohol dehydrogenase (NAD+) activity	cellular_component
YMR265C_p	YMR265C	YMR265C	hom	Uncharacterized	1.56473533063399	0.0588224903328241	no	405	0.0580278322565235	285	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YER074W	YER074W	RPS24A	hom	Verified	1.56400018842967	0.058908762083997	no	406	0.0597596337242135	282	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION	NUCLEUS|MITOCHONDRION	RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S24, no bacterial homolog; RPS24A has a paralog, RPS24B, that arose from the whole genome duplication	cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome	cytosolic small ribosomal subunit|mitochondrion
YMR173W-A_d	YMR173W-A	YMR173W-A	hom	Dubious	1.56324209886771	0.0589978307406347	no	407	0.0693864488286728	297	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene DDR48/YML173W	Unknown	Unknown	Unknown
YKL119C	YKL119C	VPH2	hom	Verified	1.55817199717361	0.0595962406068465	no	408	0.0628950277275195	272	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|ION HOMEOSTASIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Integral membrane protein required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the endoplasmic reticulum (ER)	vacuolar proton-transporting V-type ATPase complex assembly|vacuolar acidification	molecular_function	endoplasmic reticulum membrane
YIL077C_p	YIL077C	YIL077C	hom	Uncharacterized	1.55771542800699	0.0596503608002558	no	409	0.0745542698774117	292	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)	biological_process	molecular_function	mitochondrion
YBL051C	YBL051C	PIN4	hom	Verified	1.55661877144136	0.0597805121750238	no	410	0.077424619130141	339	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE			Protein involved in G2/M phase progression and response to DNA damage, interacts with Rad53p; contains an RNA recognition motif, a nuclear localization signal, and several SQ/TQ cluster domains; hyperphosphorylated in response to DNA damage	G2/M transition of mitotic cell cycle|DNA damage checkpoint	molecular_function	cytoplasm
YPR197C_d	YPR197C	YPR197C	hom	Dubious	1.55661639025405	0.0597807950165692	no	411	0.118588744099724	471	NA	FF				Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YCL030C	YCL030C	HIS4	hom	Verified	1.55328523134083	0.0601775034771825	no	412	0.0626214246193952	274	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS			Multifunctional enzyme containing phosphoribosyl-ATP pyrophosphatase, phosphoribosyl-AMP cyclohydrolase, and histidinol dehydrogenase activities; catalyzes the second, third, ninth and tenth steps in histidine biosynthesis	histidine biosynthetic process	phosphoribosyl-ATP diphosphatase activity|phosphoribosyl-AMP cyclohydrolase activity|histidinol dehydrogenase activity	intracellular
YPR043W	YPR043W	RPL43A	hom	Verified	1.54798070710609	0.0608134707952844	no	413	0.0400984931624033	211	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L43A; null mutation confers a dominant lethal phenotype; homologous to mammalian ribosomal protein L37A, no bacterial homolog; RPL43A has a paralog, RPL43B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YDL216C	YDL216C	RRI1	hom	Verified	1.54595740903758	0.0610574271261145	no	414	0.0701628327440592	293	NA	FT	SIGNALING|PROTEOLYSIS	NUCLEUS		Catalytic subunit of the COP9 signalosome (CSN) complex that acts as an isopeptidase in cleaving the ubiquitin-like protein Nedd8 from SCF ubiquitin ligases; metalloendopeptidase involved in the adaptation to pheromone signaling	adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion|cullin deneddylation	metalloendopeptidase activity	signalosome
YJL189W	YJL189W	RPL39	hom	Verified	1.54400953433508	0.0612930114430812	no	415	0.0664377526026961	266	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L39; required for ribosome biogenesis; loss of both Rpl31p and Rpl39p confers lethality; also exhibits genetic interactions with SIS1 and PAB1; homologous to mammalian ribosomal protein L39, no bacterial homolog	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YOR226C	YOR226C	ISU2	hom	Verified	1.54266197900592	0.0614564057442068	no	416	0.0552170572854985	301	NA	FT	RNA PROCESSING|ION HOMEOSTASIS|ION HOMEOSTASIS|COFACTOR METABOLISM	MITOCHONDRION		Protein required for synthesis of iron-sulfur proteins; localized to the mitochondrial matrix; performs a scaffolding function in mitochondria during Fe/S cluster assembly; involved in Fe-S cluster assembly for both mitochondrial and cytosolic proteins; isu1 isu2 double mutant is inviable; protein abundance increases in response to DNA replication stress; evolutionarily conserved	cellular iron ion homeostasis|iron-sulfur cluster assembly|tRNA wobble uridine modification	molecular_function	mitochondrial matrix
YIL149C	YIL149C	MLP2	hom	Verified	1.54085818642184	0.0616756521626442	no	417	0.0467228141043205	194	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|CYTOSKELETON ORGANIZATION|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION|CYTOSKELETON		Myosin-like protein associated with the nuclear envelope, connects the nuclear pore complex with the nuclear interior; involved in the Tel1p pathway that controls telomere length	poly(A)+ mRNA export from nucleus|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|regulation of transcription, DNA-dependent|telomere tethering at nuclear periphery|spindle pole body organization|transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery	ribonucleoprotein complex binding	nucleoplasm|nuclear envelope|mitochondrion|ribonucleoprotein complex|integral to membrane|spindle pole body
YKL212W	YKL212W	SAC1	hom	Verified	1.54060691245133	0.0617062422782023	no	418	0.159924148372777	655	NA	FF|FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION|GOLGI APPARATUS		Phosphatidylinositol phosphate (PtdInsP) phosphatase; involved in hydrolysis of PtdIns[4]P in the early and medial Golgi; regulated by interaction with Vps74p; ER localized transmembrane protein which cycles through the Golgi; involved in protein trafficking and processing, secretion, and cell wall maintenance; regulates sphingolipid biosynthesis through the modulation of PtdIns(4)P metabolism	phosphatidylinositol dephosphorylation	phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity|phosphatidylinositol-3-phosphatase activity|phosphatidylinositol-4-phosphate phosphatase activity	mitochondrial outer membrane|integral to endoplasmic reticulum membrane|mitochondrion|SPOTS complex|integral to Golgi membrane
YOR283W	YOR283W	YOR283W	hom	Verified	1.53898193332618	0.0619043534672404	no	419	0.059241307928442	240	NA	FT	CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS		Phosphatase with a broad substrate specificity and some similarity to GPM1/YKL152C, a phosphoglycerate mutase; YOR283W is not an essential gene	dephosphorylation	phosphatase activity	nucleus|cytoplasm
YNL079C	YNL079C	TPM1	hom	Verified	1.53083601976053	0.0629049624837323	no	420	0.0705789495398987	376	NA	FF|FT	VESICLE-MEDIATED TRANSPORT|CELL DIVISION|MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION|RNA LOCALIZATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Major isoform of tropomyosin; binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; acetylated by the NatB complex and acetylated form binds actin most efficiently; TPM1 has a paralog, TPM2, that arose from the whole genome duplication	vacuole inheritance|exocytosis|intracellular mRNA localization|filamentous growth|budding cell apical bud growth|mitochondrion inheritance|budding cell isotropic bud growth|actin polymerization or depolymerization|actin filament organization|pseudohyphal growth|vesicle-mediated transport|establishment of cell polarity|actin filament bundle assembly	actin lateral binding	cellular bud neck contractile ring|actin filament bundle
YOR096W	YOR096W	RPS7A	hom	Verified	1.52746682237651	0.0633224855935056	no	421	0.0909343566986568	344	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION	NUCLEUS	RIBOSOME	Protein component of the small (40S) ribosomal subunit; interacts with Kti11p; deletion causes hypersensitivity to zymocin; homologous to mammalian ribosomal protein S7, no bacterial homolog; RPS7A has a paralog, RPS7B, that arose from the whole genome duplication	cytoplasmic translation|ribosome biogenesis	structural constituent of ribosome	small-subunit processome|cytosolic small ribosomal subunit|90S preribosome
YHR157W	YHR157W	REC104	hom	Verified	1.52694004873565	0.0633879598639418	no	422	0.0540495373280994	288	NA	FT	CELL CYCLE	NUCLEUS|CHROMOSOME		Protein involved in early stages of meiotic recombination; required for meiotic crossing over; forms a complex with Rec102p and Spo11p necessary during the initiation of recombination	meiotic DNA double-strand break formation|reciprocal meiotic recombination	molecular_function	condensed nuclear chromosome
YHR080C	YHR080C	YHR080C	hom	Verified	1.52681333824079	0.0634037169498863	no	423	0.0687556459580434	317	NA	FT		MITOCHONDRION		Protein of unknown function; may interact with ribosomes, based on co-purification experiments; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YHR080C has a paralog, YSP2, that arose from the whole genome duplication	biological_process	molecular_function	mitochondrion|ribosome
YKR035C_d	YKR035C	OPI8	hom	Dubious	1.52571749860546	0.0635401173403789	no	424	0.0980459319430587	378	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene DID2/YKR035W-A	Unknown	Unknown	Unknown
YGL070C	YGL070C	RPB9	hom	Verified	1.52487311534004	0.0636453743549329	no	425	0.0944032174462685	327	NA	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO DNA DAMAGE	NUCLEUS	RNA POL II, HOLOENZYME	RNA polymerase II subunit B12.6; contacts DNA; mutations affect transcription start site selection and fidelity of transcription	transcription initiation from RNA polymerase II promoter|maintenance of transcriptional fidelity during DNA-dependent transcription elongation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|response to DNA damage stimulus|transcription from RNA polymerase II promoter	RNA-directed RNA polymerase activity	DNA-directed RNA polymerase II, core complex
YFR057W_p	YFR057W	YFR057W	hom	Uncharacterized	1.51720051407302	0.0646080332882087	no	426	0.0744760039471932	264	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YIL084C	YIL084C	SDS3	hom	Verified	1.51484461501819	0.0649058794914556	no	427	0.0745329247080505	341	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS|CHROMOSOME		Component of the Rpd3p/Sin3p deacetylase complex required for its structural integrity and catalytic activity, involved in transcriptional silencing and required for sporulation; cells defective in SDS3 display pleiotropic phenotypes	positive regulation of transcription from RNA polymerase II promoter in response to heat stress|negative regulation of chromatin silencing at silent mating-type cassette|negative regulation of chromatin silencing at telomere|chromatin silencing|negative regulation of chromatin silencing at rDNA|positive regulation of transcription from RNA polymerase II promoter|histone deacetylation	histone deacetylase activity	Rpd3L-Expanded complex|Rpd3L complex
YJR148W	YJR148W	BAT2	hom	Verified	1.51062712281837	0.0654417397857019	no	428	0.0538843522258149	252	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Cytosolic branched-chain amino acid (BCAA) aminotransferase, preferentially involved in BCAA catabolism; homolog of murine ECA39; highly expressed during stationary phase and repressed during logarithmic phase	branched-chain amino acid catabolic process|branched-chain amino acid biosynthetic process	branched-chain-amino-acid transaminase activity	nucleus|cytoplasm
YHR057C	YHR057C	CPR2	hom	Verified	1.50386168282347	0.0663084924216262	no	429	0.0639123901140737	242	NA					Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; has a potential role in the secretory pathway	biological_process	peptidyl-prolyl cis-trans isomerase activity	cellular_component
YBL012C_d	YBL012C	YBL012C	hom	Dubious	1.50336108364482	0.0663729781299146	no	430	0.0662789832142608	333	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YHR059W	YHR059W	FYV4	hom	Verified	1.50322396883146	0.0663906493244524	no	431	0.059410535877189	280	NA	FT		MITOCHONDRION		Protein of unknown function, required for survival upon exposure to K1 killer toxin	biological_process	molecular_function	mitochondrion
YLR202C_d	YLR202C	YLR202C	hom	Dubious	1.50152506036255	0.0666099049466178	no	432	0.0626523905492223	305	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YLR201C; ORF contains a putative intron	Unknown	Unknown	Unknown
YGR037C	YGR037C	ACB1	hom	Verified	1.50105152766038	0.0666711173098458	no	433	0.144831922646457	583	NA	FF|FT	KETONE METABOLISM|LIPID METABOLISM	NUCLEUS		Acyl-CoA-binding protein, transports newly synthesized acyl-CoA esters from fatty acid synthetase (Fas1p-Fas2p) to acyl-CoA-consuming processes; subject to starvation-induced, Grh1p-mediated unconventional secretion; protein abundance increases in response to DNA replication stress	long-chain fatty acid transport|chronological cell aging|fatty acid metabolic process	long-chain fatty acid transporter activity|fatty-acyl-CoA binding	extracellular region|nucleus|cytoplasm
YOR113W	YOR113W	AZF1	hom	Verified	1.49727496069631	0.067160863685878	no	434	0.0810568520569562	301	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL WALL ORG/BIOGENESIS	NUCLEUS		Zinc-finger transcription factor; in the presence of glucose, activates transcription of genes involved in growth and carbon metabolism; in nonfermentable carbon sources, activates transcription of genes involved in maintenance of cell wall integrity	regulation of fungal-type cell wall organization|regulation of transcription from RNA polymerase II promoter|cellular response to carbohydrate stimulus	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YHR094C	YHR094C	HXT1	hom	Verified	1.49673233323844	0.0672314597593002	no	435	0.0656615182429766	292	NA	FT		PLASMA MEMBRANE		Low-affinity glucose transporter of the major facilitator superfamily, expression is induced by Hxk2p in the presence of glucose and repressed by Rgt1p when glucose is limiting; HXT1 has a paralog, HXT6, what arose from the whole genome duplication	mannose transport|glucose transport	galactose transmembrane transporter activity|pentose transmembrane transporter activity|mannose transmembrane transporter activity|glucose transmembrane transporter activity|fructose transmembrane transporter activity	integral to membrane|plasma membrane
YGL125W	YGL125W	MET13	hom	Verified	1.49658517800053	0.0672506146069064	no	436	0.0739747804532818	230	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS	MITOCHONDRION		Major isozyme of methylenetetrahydrofolate reductase, catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate in the methionine biosynthesis pathway	methionine biosynthetic process	methylenetetrahydrofolate reductase (NADPH) activity	mitochondrion
YJL099W	YJL099W	CHS6	hom	Verified	1.49367901409539	0.0676297681136602	no	437	0.0853164260218926	362	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	GOLGI APPARATUS		Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; CHS6 has a paralog, BCH2, that arose from the whole genome duplication	Golgi to plasma membrane transport|fungal-type cell wall chitin biosynthetic process	molecular_function	trans-Golgi network transport vesicle|clathrin-coated vesicle|exomer complex
YHR202W_p	YHR202W	YHR202W	hom	Uncharacterized	1.49241731209443	0.0677948896889506	no	438	0.0681634836793121	306	NA	FT	NUCLEOTIDE METABOLISM			Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole, while HA-tagged protein is found in the soluble fraction, suggesting cytoplasmic localization	biological_process	molecular_function	cytosol|fungal-type vacuole
YPL201C	YPL201C	YIG1	hom	Verified	1.49157754809246	0.0679049638400337	no	439	0.0705979507482905	320	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS		Protein that interacts with glycerol 3-phosphatase and plays a role in anaerobic glycerol production; localizes to the nucleus and cytosol	glycerol biosynthetic process	molecular_function	cytosol|nucleus
YPL244C	YPL244C	HUT1	hom	Verified	1.48779001705192	0.068403139604171	no	440	0.0665426453814695	289	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein with a role in UDP-galactose transport to the Golgi lumen, has similarity to human UDP-galactose transporter UGTrel1, exhibits a genetic interaction with S. cerevisiae ERO1	UDP-galactose transport|UDP-glucose transport	UDP-galactose transmembrane transporter activity	integral to membrane
YOL128C	YOL128C	YGK3	hom	Verified	1.48758151017275	0.0684306462883913	no	441	0.07431897740128	302	NA	FT	PROTEOLYSIS|PROTEIN PHOSPHORYLATION			Protein kinase related to mammalian glycogen synthase kinases of the GSK-3 family; GSK-3 homologs (Mck1p, Rim11p, Mrk1p, Ygk3p) are involved in control of Msn2p-dependent transcription of stress responsive genes and in protein degradation	proteolysis|protein phosphorylation|response to stress	protein serine/threonine kinase activity|protein kinase activity	cellular_component
YGL181W	YGL181W	GTS1	hom	Verified	1.48714986485438	0.0684876170032122	no	442	0.0703344184438147	229	NA	FT	VESICLE-MEDIATED TRANSPORT|TRANSCRIPTION FROM RNA POL II|LIPID METABOLISM|MEMBRANE ORGANIZATION|SIGNALING|NUCLEOTIDE METABOLISM	NUCLEUS|CYTOSKELETON		Protein involved in Arf3p regulation and in transcription regulation; localizes to the nucleus and to endocytic patches; contains an N-terminal Zn-finger and ArfGAP homology domain, a C-terminal glutamine-rich region, and a UBA (ubiquitin associated) domain; gts1 mutations affect budding, cell size, heat tolerance, sporulation, life span, ultradian rhythms, endocytosis; expression oscillates in a pattern similar to metabolic oscillations	endocytosis|ultradian rhythm|regulation of transcription from RNA polymerase II promoter|negative regulation of phosphatidylinositol biosynthetic process|positive regulation of transcription from RNA polymerase II promoter	ARF GTPase activator activity|repressing transcription factor binding|transcription factor binding transcription factor activity	nucleus|cytoplasm|actin cortical patch
YBR158W	YBR158W	AMN1	hom	Verified	1.48677811343606	0.0685367119406271	no	443	0.0740359604418488	324	NA	FT	CELL CYCLE|CELL DIVISION	NUCLEUS		Protein required for daughter cell separation, multiple mitotic checkpoints, and chromosome stability; contains 12 degenerate leucine-rich repeat motifs; expression is induced by the Mitotic Exit Network (MEN)	mitotic cell cycle checkpoint|negative regulation of exit from mitosis	protein binding	nucleus|cellular bud|cytoplasm
YHR125W_d	YHR125W	YHR125W	hom	Dubious	1.48530183231023	0.0687319433613251	no	444	0.0796930907543082	376	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YIL017C	YIL017C	VID28	hom	Verified	1.48402714559525	0.0689008595960609	no	445	0.0759687256301532	279	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|CARBOHYDRATE METABOLISM|PROTEOLYSIS	NUCLEUS		GID Complex subunit, serves as adaptor for regulatory subunit Vid24p; protein involved in proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBPase); localized to the nucleus and the cytoplasm	negative regulation of gluconeogenesis|proteasomal ubiquitin-dependent protein catabolic process|vacuolar protein catabolic process|ascospore formation|positive regulation of transcription from RNA polymerase II promoter	molecular_function	nucleus|GID complex|cytoplasm
YCL011C	YCL011C	GBP2	hom	Verified	1.48245846844143	0.0691091732600039	no	446	0.0871650548179101	346	NA	FT	RNA LOCALIZATION	NUCLEUS|CHROMOSOME		Poly(A+) RNA-binding protein; involved in the export of mRNAs from the nucleus to the cytoplasm; similar to Npl3p; also binds single-stranded telomeric repeat sequence in vitro; GBP2 has a paralog, HRB1, that arose from the whole genome duplication	poly(A)+ mRNA export from nucleus|telomere maintenance	RNA binding|telomeric DNA binding	nucleus|cytoplasmic stress granule
YIL036W	YIL036W	CST6	hom	Verified	1.48187819642648	0.0691863537716737	no	447	0.0502614878979493	292	NA	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Basic leucine zipper (bZIP) transcription factor, in ATF/CREB family; mediates transcriptional activation of NCE103 (encoding carbonic anhydrase) in response to low CO2 levels such as in the ambient air; proposed to be a regulator of oleate responsive genes; involved in utilization of non-optimal carbon sources and chromosome stability; CST6 has a paralog, ACA1, that arose from the whole genome duplication	cellular response to carbon dioxide|positive regulation of transcription from RNA polymerase II promoter by oleic acid|cellular response to oleic acid|positive regulation of transcription from RNA polymerase II promoter|DNA metabolic process	sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YPR029C	YPR029C	APL4	hom	Verified	1.4804609838758	0.0693751327904615	no	448	0.0597718672882166	267	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Gamma-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in vesicle mediated transport	Golgi to vacuole transport|vesicle-mediated transport	clathrin binding	AP-1 adaptor complex
YBR179C	YBR179C	FZO1	hom	Verified	1.48011451572156	0.0694213441880683	no	449	0.0791834141396052	349	NA	FT	MEMBRANE ORGANIZATION|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitofusin; integral membrane protein involved in mitochondrial outer membrane tethering and fusion; role in mitochondrial genome maintenance; efficient tethering and degradation of Fzo1p requires an intact N-terminal GTPase domain; targeted for destruction by the ubiquitin ligase SCF-Mdm30p and the cytosolic ubiquitin-proteasome system	mitochondrial fusion	GTPase activity|protein homodimerization activity	mitochondrial outer membrane|mitochondrion|mitochondrial inner membrane|integral to mitochondrial outer membrane
YMR068W	YMR068W	AVO2	hom	Verified	1.47776037846117	0.0697359634924125	no	450	0.0737661097256663	293	NA	FT	SIGNALING|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION	PLASMA MEMBRANE		Component of a complex containing the Tor2p kinase and other proteins, which may have a role in regulation of cell growth	fungal-type cell wall organization|TOR signaling cascade|regulation of cell growth|establishment or maintenance of actin cytoskeleton polarity	molecular_function	TORC2 complex|cytoplasm
YIL035C	YIL035C	CKA1	hom	Verified	1.47676685541337	0.0698690720314991	no	451	0.0787547950526961	356	NA	FT	RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION	NUCLEUS		Alpha catalytic subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases; regulates Fkh1p-mediated donor preference during mating-type switching	regulation of transcription from RNA polymerase I promoter|protein phosphorylation|regulation of transcription from RNA polymerase III promoter|response to DNA damage stimulus	protein serine/threonine kinase activity|protein kinase activity	protein kinase CK2 complex|UTP-C complex
YMR034C_p	YMR034C	YMR034C	hom	Uncharacterized	1.47642911250958	0.0699143660796137	no	452	0.0776315904920671	231	NA					Putative transporter, member of the SLC10 carrier family; identified in a transposon mutagenesis screen as a gene involved in azole resistance; YMR034C is not an essential gene	biological_process	sterol transporter activity	integral to membrane
YDR442W_d	YDR442W	YDR442W	hom	Dubious	1.46916589697856	0.070893898868579	no	453	0.0997262207112924	367	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YJL164C	YJL164C	TPK1	hom	Verified	1.4658397397291	0.0713459759390121	no	454	0.0715551913470803	317	NA	FT	CELL CYCLE|SIGNALING|CELL DIVISION|PROTEIN PHOSPHORYLATION	NUCLEUS		cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; regulates Whi3p; partially redundant with Tpk2p and Tpk3p; TPK1 has a paralog, TPK3, that arose from the whole genome duplication	protein phosphorylation|Ras protein signal transduction	cAMP-dependent protein kinase activity|protein kinase activity	cAMP-dependent protein kinase complex|nucleus|cytoplasm
YAL018C_p	YAL018C	YAL018C	hom	Uncharacterized	1.46502081904579	0.0714576188831875	no	455	0.0768935485462728	279	NA					Putative protein of unknown function	biological_process	molecular_function	integral to membrane
YBR056W-A_p	YBR056W-A	YBR056W-A	hom	Uncharacterized	1.4641255768786	0.0715798200308641	no	456	0.0948316008962278	375	NA					Protein of unknown function; mRNA identified as translated by ribosome profiling data; partially overlaps the dubious ORF YBR056C-B	biological_process	molecular_function	cellular_component
YDR156W	YDR156W	RPA14	hom	Verified	1.46223122556765	0.0718389287822968	no	457	0.0527803642141675	248	NA	FT		NUCLEUS		RNA polymerase I subunit A14	transcription of nuclear large rRNA transcript from RNA polymerase I promoter|regulation of cell size	molecular_function	DNA-directed RNA polymerase I complex
YKL097C_d	YKL097C	YKL097C	hom	Dubious	1.46202303935443	0.0718674482385012	no	458	0.0567237618620763	213	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related <i>Saccharomyces</i> species	Unknown	Unknown	Unknown
YOR221C	YOR221C	MCT1	hom	Verified	1.4617001715565	0.0719116951131738	no	459	0.0986858348050724	403	NA	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Predicted malonyl-CoA:ACP transferase, putative component of a type-II mitochondrial fatty acid synthase that produces intermediates for phospholipid remodeling	fatty acid metabolic process|aerobic respiration	[acyl-carrier-protein] S-malonyltransferase activity	mitochondrion
YPR120C	YPR120C	CLB5	hom	Verified	1.46065606357805	0.0720549261492539	no	460	0.0878144747008333	373	NA	FT	CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION	NUCLEUS		B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1 phase	spindle assembly|G1/S transition of mitotic cell cycle|regulation of S phase of mitotic cell cycle|G2/M transition of mitotic cell cycle|regulation of cyclin-dependent protein kinase activity|positive regulation of spindle pole body separation|premeiotic DNA replication|positive regulation of DNA replication	cyclin-dependent protein kinase regulator activity	nucleus
YDR058C	YDR058C	TGL2	hom	Verified	1.46061970746756	0.0720599174285165	no	461	0.0750756744444279	345	NA	FT	PROTEIN LOCALIZATION|LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION		Triacylglycerol lipase that is localized to the mitochondria; has lipolytic activity towards triacylglycerols and diacylglycerols when expressed in E. coli	triglyceride catabolic process	triglyceride lipase activity	mitochondrion
YOR349W	YOR349W	CIN1	hom	Verified	1.45927667744801	0.0722444859414525	no	462	0.0722442620968732	420	NA	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS			Tubulin folding factor D involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl	protein folding|tubulin complex assembly|tubulin complex biogenesis	beta-tubulin binding	cellular_component
YLR284C	YLR284C	ECI1	hom	Verified	1.45713496237363	0.0725395645525447	no	463	0.0770343225004194	313	NA	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS			Peroxisomal delta3,delta2-enoyl-CoA isomerase, hexameric protein that converts 3-hexenoyl-CoA to trans-2-hexenoyl-CoA, essential for the beta-oxidation of unsaturated fatty acids, oleate-induced	fatty acid beta-oxidation	dodecenoyl-CoA delta-isomerase activity	peroxisome
YOL087C	YOL087C	DUF1	hom	Verified	1.45682632178922	0.0725821640568941	no	464	0.128272100372893	444	NA					Ubiquitin-binding protein of unknown function; contains one WD40 repeat in a beta-propeller fold; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; homolog of human WDR48/UAF1, which is involved in regulating the Fanconi anemia pathway; deletion mutant is sensitive to various chemicals including phenanthroline, sanguinarine, and nordihydroguaiaretic acid	biological_process	ubiquitin binding	cytoplasm
YFR026C	YFR026C	ULI1	hom	Verified	1.45335923094419	0.0730620198753729	no	465	0.0724568981778026	240	NA	FT	SIGNALING			Putative protein of unknown function involved in and induced by the endoplasmic reticulum unfolded protein response	endoplasmic reticulum unfolded protein response	molecular_function	cellular_component
YOR323C	YOR323C	PRO2	hom	Verified	1.45082463682167	0.0734143487580068	no	466	0.170407298508624	701	NA	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS	NUCLEUS		Gamma-glutamyl phosphate reductase, catalyzes the second step in proline biosynthesis	proline biosynthetic process	glutamate-5-semialdehyde dehydrogenase activity	nucleus|cytoplasm
YHR081W	YHR081W	LRP1	hom	Verified	1.44882432004529	0.0736933250983461	no	467	0.0694573648069913	284	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|RNA LOCALIZATION	NUCLEUS		Nuclear exosome-associated nucleic acid binding protein; involved in RNA processing, surveillance, degradation, tethering, and export; homolog of mammalian nuclear matrix protein C1D involved in regulation of DNA repair and recombination	U5 snRNA 3'-end processing|nuclear mRNA surveillance|nuclear polyadenylation-dependent CUT catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|nuclear retention of pre-mRNA at the site of transcription|U4 snRNA 3'-end processing|polyadenylation-dependent snoRNA 3'-end processing|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	double-stranded RNA binding|double-stranded DNA binding	nuclear exosome (RNase complex)
YLR032W	YLR032W	RAD5	hom	Verified	1.44706758898313	0.0739389972362304	no	468	0.0827917397583276	375	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		DNA helicase; proposed to promote replication fork regression during postreplication repair by template switching; RING finger containing ubiquitin ligase; stimulates the synthesis of free and PCNA-bound polyubiquitin chains by Ubc13p-Mms2p; required for error-prone translesion synthesis; forms nuclear foci upon DNA replication stress	double-strand break repair|postreplication repair|protein polyubiquitination|free ubiquitin chain polymerization	four-way junction helicase activity|four-way junction DNA binding|DNA-dependent ATPase activity|Y-form DNA binding	nuclear chromatin
YLR220W	YLR220W	CCC1	hom	Verified	1.44485160013691	0.0742497868281785	no	469	0.0663492060094522	302	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Putative vacuolar Fe2+/Mn2+ transporter; suppresses respiratory deficit of yfh1 mutants, which lack the ortholog of mammalian frataxin, by preventing mitochondrial iron accumulation; relative distribution to the vacuole decreases upon DNA replication stress	manganese ion transport|cellular calcium ion homeostasis|cellular iron ion homeostasis|cellular manganese ion homeostasis|ferrous iron transport	manganese ion transmembrane transporter activity|ferrous iron transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane|Golgi apparatus
YAR002W	YAR002W	NUP60	hom	Verified	1.43572305262298	0.0755405814292844	no	470	0.0937289154802489	349	NA	FT	PROTEIN LOCALIZATION|RESPONSE TO DNA DAMAGE|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier and is involved in gene tethering at the nuclear periphery; both NUP1 and NUP60 are homologous to human NUP153	double-strand break repair|poly(A)+ mRNA export from nucleus|protein export from nucleus|regulation of protein desumoylation|intracellular mRNA localization|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|telomere tethering at nuclear periphery|mRNA export from nucleus in response to heat stress|transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery|NLS-bearing substrate import into nucleus|chromosome organization|nucleocytoplasmic transport|chromatin silencing at silent mating-type cassette	nucleocytoplasmic transporter activity|phospholipid binding|structural constituent of nuclear pore	nuclear pore central transport channel|nuclear pore nuclear basket|integral to membrane|nuclear pore
YNL155W	YNL155W	YNL155W	hom	Verified	1.43566099855244	0.0755494141384486	no	471	0.0595903954253675	281	NA	FT		NUCLEUS		Protein of unknown function; contains a DHHC domain and an AN1-type zinc finger; predicted to have thiol-disulfide oxidoreductase active site; transcriptionally regulated by Rpn4p along with proteasome subunit genes; putative ortholog of human AIRAP, which stimulates proteasome activity in response to arsenic; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	nucleus|cytoplasm
YJL132W_p	YJL132W	YJL132W	hom	Uncharacterized	1.42742282531762	0.0767290277485222	no	472	0.0703533412298547	279	NA					Putative protein of unknown function; localizes to the membrane fraction; possible Zap1p-regulated target gene induced by zinc deficiency; YJL132W is a non-essential gene	biological_process	molecular_function	membrane
YDR287W	YDR287W	INM2	hom	Verified	1.42630110002621	0.0768907236158551	no	473	0.0752608911503774	315	NA	FT	LIPID METABOLISM|CARBOHYDRATE METABOLISM			Inositol monophosphatase, involved in biosynthesis of inositol; enzymatic activity requires magnesium ions and is inhibited by lithium and sodium ions; inm1 inm2 double mutant lacks inositol auxotrophy	inositol phosphate dephosphorylation	inositol monophosphate 1-phosphatase activity	cellular_component
YGL232W	YGL232W	TAN1	hom	Verified	1.42398683977981	0.0772251408431332	no	474	0.0815981162160981	323	NA	FT	RNA PROCESSING	NUCLEUS		Putative tRNA acetyltransferase; RNA-binding protein required for the formation of the modified nucleoside N(4)-acetylcytidine in serine and leucine tRNAs but not required for the same modification in 18S rRNA; protein abundance increases in response to DNA replication stress	tRNA modification	RNA binding	nucleus|cytoplasm
YGL127C	YGL127C	SOH1	hom	Verified	1.42128631115988	0.0776167707125154	no	475	0.0916295408934267	390	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION	NUCLEUS	RNA POL II, HOLOENZYME	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; involved in telomere maintenance; conserved with other metazoan MED31 subunits	DNA repair|meiotic gene conversion|meiotic sister chromatid segregation|transcription from RNA polymerase II promoter	molecular_function	core mediator complex|nucleus
YDR525W_d	YDR525W	API2	hom	Dubious	1.41985746883706	0.0778245900509347	no	476	0.114664983303929	410	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 26% of ORF overlaps the dubious ORF YDR524C-A; insertion mutation in a cdc34-2 mutant background causes altered bud morphology	Unknown	Unknown	Unknown
YIL159W	YIL159W	BNR1	hom	Verified	1.41937004687245	0.077895580125408	no	477	0.0740678976265199	284	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH		Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNI1	barbed-end actin filament capping|actin filament bundle assembly|formin-nucleated actin cable assembly	profilin binding	cellular bud neck
YNR018W	YNR018W	RCF2	hom	Verified	1.41916413394497	0.0779255848642008	no	478	0.0684366502532163	294	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Cytochrome c oxidase subunit; has a role in assembly of respiratory supercomplexes; similar to Rcf1p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; associates with the cytochrome c oxidase - cytochrome bc1 supercomplex; null mutant accumulates reactive oxygen species; member of the conserved hypoxia induced gene family; C. elegans homolog is functional in yeast	mitochondrial respiratory chain complex IV assembly	molecular_function	mitochondrion|mitochondrial respiratory chain supercomplex|mitochondrial respiratory chain complex IV|integral to mitochondrial inner membrane
YKR099W	YKR099W	BAS1	hom	Verified	1.41770802753197	0.0781380127161685	no	479	0.0817622870966614	323	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Myb-related transcription factor involved in regulating basal and induced expression of genes of the purine and histidine biosynthesis pathways; also involved in regulation of meiotic recombination at specific genes	positive regulation of transcription from RNA polymerase II promoter	core promoter sequence-specific DNA binding|sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|RNA polymerase II transcription factor recruiting transcription factor activity	nucleus
YGL056C	YGL056C	SDS23	hom	Verified	1.41674786613613	0.078278328484359	no	480	0.0809113237695942	342	NA	FT	CELL DIVISION	NUCLEUS		One of two S. cerevisiae homologs (Sds23p and Sds24p) of the S. pombe Sds23 protein, which is implicated in APC/cyclosome regulation; involved in cell separation during budding; SDS23 has a paralog, SDS24, that arose from the whole genome duplication	cytokinetic cell separation	molecular_function	nucleus|cytoplasm
YGR180C	YGR180C	RNR4	hom	Verified	1.41621267679798	0.0783566227125658	no	481	0.109097002023163	411	NA	FT	OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM	NUCLEUS		Ribonucleotide-diphosphate reductase (RNR) small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits; relocalizes from nucleus to cytoplasm upon DNA replication stress	cofactor biosynthetic process|deoxyribonucleotide biosynthetic process	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	ribonucleoside-diphosphate reductase complex|nucleus|cytoplasm
YOR277C_d	YOR277C	YOR277C	hom	Dubious	1.41192243064666	0.078986401167286	no	482	0.0972259962505204	378	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the verified gene CAF20	Unknown	Unknown	Unknown
YDR395W	YDR395W	SXM1	hom	Verified	1.41005162177489	0.0792622203691338	no	483	0.0803815652354528	333	NA	FT	PROTEIN LOCALIZATION|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS		Nuclear transport factor (karyopherin) involved in protein transport between the cytoplasm and nucleoplasm; similar to Nmd5p, Cse1p, Lph2p, and the human cellular apoptosis susceptibility protein, CAS1	mRNA export from nucleus|nucleocytoplasmic transport	protein transporter activity	integral to membrane|nucleus|cytoplasm
YKL133C_p	YKL133C	YKL133C	hom	Uncharacterized	1.40810161556474	0.0795504913664303	no	484	0.095965390257942	335	NA					Putative protein of unknown function; has similarity to Mgr3p, but unlike MGR3, is not required for growth of cells lacking the mitochondrial genome (null mutation does not confer a petite-negative phenotype)	biological_process	molecular_function	cellular_component
YGL028C	YGL028C	SCW11	hom	Verified	1.40735955598204	0.0796603987812952	no	485	0.0885959151961709	324	NA	FT	CELL WALL ORG/BIOGENESIS|CELL DIVISION|CARBOHYDRATE METABOLISM			Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on its regulation by Ste12p	cytokinesis, completion of separation	glucan endo-1,3-beta-D-glucosidase activity	fungal-type cell wall
YPL173W	YPL173W	MRPL40	hom	Verified	1.4062015258127	0.0798321456135739	no	486	0.0925498335572383	410	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YIR005W	YIR005W	IST3	hom	Verified	1.40595132241616	0.0798692899083743	no	487	0.0700361610026188	321	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RNA LOCALIZATION	NUCLEUS		Component of the U2 snRNP, required for the first catalytic step of splicing and for spliceosomal assembly; interacts with Rds3p and is required for Mer1p-activated splicing	mRNA export from nucleus|spliceosomal complex assembly|mRNA splicing, via spliceosome|generation of catalytic spliceosome for first transesterification step	first spliceosomal transesterification activity	RES complex|U2 snRNP
YKR074W	YKR074W	AIM29	hom	Verified	1.40594481816403	0.0798702556804829	no	488	0.0764026532692774	336	NA					Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm; YKR074W is not an essential gene; null mutant displays elevated frequency of mitochondrial genome loss	biological_process	molecular_function	cytoplasm
YBR238C	YBR238C	YBR238C	hom	Verified	1.40568072466631	0.0799094765854236	no	489	0.118555514602174	436	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Mitochondrial membrane protein with similarity to Rmd9p; not required for respiratory growth but causes a synthetic respiratory defect in combination with rmd9 mutations; transcriptionally up-regulated by TOR; deletion increases life span	aerobic respiration	molecular_function	mitochondrion|integral to mitochondrial membrane|cytoplasm
YPL170W	YPL170W	DAP1	hom	Verified	1.40432082383532	0.0801116680335807	no	490	0.0997329807081191	420	NA	FT	LIPID METABOLISM			Heme-binding protein involved in regulation of cytochrome P450 protein Erg11p; damage response protein, related to mammalian membrane progesterone receptors; mutations lead to defects in telomeres, mitochondria, and sterol synthesis	regulation of ergosterol biosynthetic process	heme binding	endosome|membrane
YDR014W	YDR014W	RAD61	hom	Verified	1.40339798957737	0.0802490960872149	no	491	0.100288701485983	385	NA	FT	CELL CYCLE|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME		Subunit of a complex (Scc3p, Pds5p, Rad61p) that inhibits sister chromatid cohesion; inhibited by Eco1p-acetylated cohesin subunits Smc3p and Mcd1p; related to the human Wapl protein that controls the association of cohesin with chromatin	mitotic sister chromatid cohesion	molecular_function	nuclear cohesin complex
YNL230C	YNL230C	ELA1	hom	Verified	1.40281167706919	0.0803365019912153	no	492	0.0885799139413423	359	NA	FT	PROTEOLYSIS	NUCLEUS	UBIQUITIN LIGASE COMPLEX	Elongin A; F-box protein that forms a heterodimer with Elc1p and is required for ubiquitin-dependent degradation of the RNA Polymerase II subunit Rpo21p; subunit of the Elongin-Cullin-Socs (ECS) ligase complex	protein ubiquitination involved in ubiquitin-dependent protein catabolic process	ubiquitin-protein ligase activity	elongin complex|Cul3-RING ubiquitin ligase complex
YLL047W_d	YLL047W	YLL047W	hom	Dubious	1.4027868997902	0.0803401973055027	no	493	0.0904797758688949	347	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene RNP1	Unknown	Unknown	Unknown
YCL009C	YCL009C	ILV6	hom	Verified	1.40046266019909	0.0806874087272205	no	494	0.0738761877562249	307	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		Regulatory subunit of acetolactate synthase, which catalyzes the first step of branched-chain amino acid biosynthesis; enhances activity of the Ilv2p catalytic subunit, localizes to mitochondria	branched-chain amino acid biosynthetic process	enzyme regulator activity|acetolactate synthase activity	mitochondrial nucleoid|acetolactate synthase complex|mitochondrion
YLR399C	YLR399C	BDF1	hom	Verified	1.39788001536211	0.0810745504366177	no	495	0.0748779119018635	386	NA	FT	CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING	NUCLEUS|CHROMOSOME		Protein involved in transcription initiation at TATA-containing promoters; associates with the basal transcription factor TFIID; contains two bromodomains; corresponds to the C-terminal region of mammalian TAF1; redundant with Bdf2p	DNA repair|snRNA transcription|regulation of chromatin silencing at telomere|regulation of transcription by chromatin organization|regulation of chromatin silencing at silent mating-type cassette|Unknown|chromatin remodeling|negative regulation of heterochromatin assembly	histone acetyl-lysine binding|chromatin binding|core promoter binding|TFIID-class transcription factor binding	nuclear chromatin|Swr1 complex
YLR403W	YLR403W	SFP1	hom	Verified	1.3914549310777	0.0820437586272912	no	496	0.0774089824615045	365	NA	FT	TRANSCRIPTION FROM RNA POL II|RIBOSOME BIOGENESIS	NUCLEUS		Regulates transcription of ribosomal protein and biogenesis genes; regulates response to nutrients and stress, G2/M transitions during mitotic cell cycle and DNA-damage response, and modulates cell size; regulated by TORC1 and Mrs6p; sequence of zinc finger, ChIP localization data, and protein-binding microarray (PBM) data, and computational analyses suggest it binds DNA directly at highly active RP genes and indirectly through Rap1p at others; can form the [ISP+] prion	positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter|regulation of cell size|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II transcription factor binding transcription factor activity	nucleus|cytoplasm
YER180C	YER180C	ISC10	hom	Verified	1.39056484273116	0.0821787118160677	no	497	0.0802304239874848	350	NA	FT	CELL CYCLE			Protein required for sporulation, transcript is induced 7.5 hours after induction of meiosis, expected to play significant role in the formation of reproductive cells	sporulation resulting in formation of a cellular spore	molecular_function	cellular_component
YIL133C	YIL133C	RPL16A	hom	Verified	1.38575009762293	0.0829116124757088	no	498	0.0890682384214251	369	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L16A; N-terminally acetylated, binds 5.8 S rRNA; transcriptionally regulated by Rap1p; homologous to mammalian ribosomal protein L13A and bacterial L13; RPL16A has a paralog, RPL16B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress	cytoplasmic translation	structural constituent of ribosome|RNA binding	cytosolic large ribosomal subunit
YOR338W_p	YOR338W	YOR338W	hom	Uncharacterized	1.38338094343808	0.0832740452936636	no	499	0.065043262246894	310	NA	FT	TRANSCRIPTION FROM RNA POL II			Putative protein of unknown function; YOR338W transcription is regulated by Azf1p and its transcript is a specific target of the G protein effector Scp160p; identified as being required for sporulation in a high-throughput mutant screen; YOR338W has a paralog, FUN19, that arose from the whole genome duplication	ascospore formation|positive regulation of transcription from RNA polymerase II promoter	molecular_function	cellular_component
YML007W	YML007W	YAP1	hom	Verified	1.38323643293165	0.0832961909686664	no	500	0.101823903301188	410	NA	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		Basic leucine zipper (bZIP) transcription factor; required for oxidative stress tolerance; activated by H2O2 through the multistep formation of disulfide bonds and transit from the cytoplasm to the nucleus; Yap1p is degraded in the nucleus after the oxidative stress has passed; mediates resistance to cadmium; YAP1 has a paralog, CAD1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress	positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance|response to heat|response to drug|response to singlet oxygen|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|response to metal ion	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	nucleus|cytoplasm
YOR085W	YOR085W	OST3	hom	Verified	1.38007198374555	0.0837822411911213	no	501	0.0813562861979996	309	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Gamma subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; Ost3p is important for N-glycosylation of a subset of proteins	protein glycosylation|protein complex assembly|protein O-linked mannosylation|protein N-linked glycosylation	dolichyl-diphosphooligosaccharide-protein glycotransferase activity	oligosaccharyltransferase complex|integral to membrane
YMR244W_p	YMR244W	YMR244W	hom	Uncharacterized	1.37954829621089	0.0838628831152277	no	502	0.0605394025607353	273	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YGL135W	YGL135W	RPL1B	hom	Verified	1.37845305618818	0.0840317260489369	no	503	0.0892165008877105	354	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L1B; N-terminally acetylated; homologous to mammalian ribosomal protein L10A and bacterial L1; RPL1B has a paralog, RPL1A, that arose from the whole genome duplication; rpl1a rpl1b double null mutation is lethal	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YER087C-B	YER087C-B	SBH1	hom	Verified	1.37750179050637	0.0841785807993063	no	504	0.121201006795337	449	NA	FT	PROTEIN LOCALIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Beta subunit of the Sec61p ER translocation complex (Sec61p-Sss1p-Sbh1p); involved in protein translocation into the endoplasmic reticulum; interacts with the exocyst complex and also with Rtn1p; homologous to Sbh2p	posttranslational protein targeting to membrane, translocation|SRP-dependent cotranslational protein targeting to membrane, translocation	ARF guanyl-nucleotide exchange factor activity|P-P-bond-hydrolysis-driven protein transmembrane transporter activity	Sec61 translocon complex
YGR259C_d	YGR259C	YGR259C	hom	Dubious	1.37600976866793	0.0844093044620452	no	505	0.073480742268694	333	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF TNA1/YGR260W	Unknown	Unknown	Unknown
YOR155C	YOR155C	ISN1	hom	Verified	1.37595783108047	0.0844173445378748	no	506	0.0803957020058172	262	NA	FT	NUCLEOTIDE METABOLISM			Inosine 5'-monophosphate (IMP)-specific 5'-nucleotidase, catalyzes the breakdown of IMP to inosine, does not show similarity to known 5'-nucleotidases from other organisms	nicotinamide riboside biosynthetic process|inosine salvage|nicotinic acid riboside biosynthetic process	IMP 5'-nucleotidase activity	cellular_component
YKL150W	YKL150W	MCR1	hom	Verified	1.37494947642445	0.0845735543972799	no	507	0.111322177409693	361	NA	FT	LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS	MITOCHONDRION		Mitochondrial NADH-cytochrome b5 reductase, involved in ergosterol biosynthesis	ergosterol biosynthetic process|cellular response to oxidative stress	cytochrome-b5 reductase activity	mitochondrial outer membrane|mitochondrion|integral to mitochondrial outer membrane|mitochondrial intermembrane space
YGL223C	YGL223C	COG1	hom	Verified	1.36823541686672	0.0856191994511362	no	508	0.136992947037042	457	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments	retrograde transport, vesicle recycling within Golgi|intra-Golgi vesicle-mediated transport|CVT pathway	molecular_function	Golgi transport complex
YKL187C	YKL187C	FAT3	hom	Verified	1.36737148698952	0.0857544474277375	no	509	0.065674400319406	248	NA	FT		MITOCHONDRION		Protein required for fatty acid uptake; Fat3p abundance increases in cortical patches in response to oleate exposure; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion|integral to membrane
YLR423C	YLR423C	ATG17	hom	Verified	1.36713000037707	0.08579228067251	no	510	0.0953428223361186	413	NA	FT	MEMBRANE ORGANIZATION|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS|PEROXISOME ORGANIZATION			Scaffold protein responsible for phagophore assembly site organization; regulatory subunit of an autophagy-specific complex that includes Atg1p and Atg13p; stimulates Atg1p kinase activity; human ortholog RB1CC1/FIP200 interacts with p53, which inhibits autophagy in human cells	piecemeal microautophagy of nucleus|mitochondrion degradation|peroxisome degradation|activation of protein kinase activity|autophagic vacuole assembly	protein kinase activator activity|protein complex scaffold	pre-autophagosomal structure|Atg1p signaling complex
YDR475C	YDR475C	JIP4	hom	Verified	1.36502500038047	0.0861225962532258	no	511	0.0813595960541516	324	NA					Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence	biological_process	molecular_function	cellular_component
YOR107W	YOR107W	RGS2	hom	Verified	1.36298827575756	0.0864431028249322	no	512	0.0982838336502771	390	NA	FT	SIGNALING	NUCLEUS|PLASMA MEMBRANE		Negative regulator of glucose-induced cAMP signaling; directly activates the GTPase activity of the heterotrimeric G protein alpha subunit Gpa2p	adenylate cyclase-modulating G-protein coupled receptor signaling pathway	GTPase activator activity	nucleus|cytoplasm
YKL148C	YKL148C	SDH1	hom	Verified	1.36237337643994	0.0865400407190493	no	513	0.119926394860442	507	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Flavoprotein subunit of succinate dehydrogenase; couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain; FAD binding to Sdh1p is required for the assembly of the succinate dehydrogenase subunits	cellular respiration|mitochondrial electron transport, succinate to ubiquinone|tricarboxylic acid cycle	succinate dehydrogenase (ubiquinone) activity|flavin adenine dinucleotide binding	mitochondrial respiratory chain complex II|mitochondrion|mitochondrial membrane
YBR005W	YBR005W	RCR1	hom	Verified	1.36179747960083	0.0866309036091294	no	514	0.0776177229704257	292	NA	FT	VESICLE-MEDIATED TRANSPORT|CELL WALL ORG/BIOGENESIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein of the ER membrane involved in cell wall chitin deposition; may function in the endosomal-vacuolar trafficking pathway, helping determine whether plasma membrane proteins are degraded or routed to the plasma membrane; RCR1 has a paralog, RCR2, that arose from the whole genome duplication	fungal-type cell wall organization|vesicle-mediated transport	molecular_function	integral to endoplasmic reticulum membrane
YGL057C	YGL057C	GEP7	hom	Verified	1.3609543990029	0.0867640503493435	no	515	0.0968033056070062	342	NA	FT		MITOCHONDRION		Protein of unknown function; null mutant exhibits a respiratory growth defect and synthetic interactions with prohibitin (phb1) and gem1; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YGL105W	YGL105W	ARC1	hom	Verified	1.36056310697826	0.0868258985760541	no	516	0.0988517098492802	387	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION			Protein that binds tRNA and methionyl- and glutamyl-tRNA synthetases (Mes1p and Gus1p), delivering tRNA to them, stimulating catalysis, and ensuring their localization to the cytoplasm; also binds quadruplex nucleic acids; protein abundance increases in response to DNA replication stress	positive regulation of ligase activity|tRNA aminoacylation for protein translation	enzyme activator activity|tRNA binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding	methionyl glutamyl tRNA synthetase complex|cytoplasm
YOR235W_d	YOR235W	IRC13	hom	Dubious	1.35873584996204	0.0871151538085633	no	517	0.125010822194935	465	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays increased levels of spontaneous Rad52 foci	Unknown	Unknown	Unknown
YDR363W	YDR363W	ESC2	hom	Verified	1.35866494335552	0.0871263928290238	no	518	0.103364687507904	383	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION|GENE SILENCING	NUCLEUS		Sumo-like domain protein; prevents accumulation of toxic intermediates during replication-associated recombinational repair; roles in silencing, lifespan, chromatid cohesion and the intra-S-phase DNA damage checkpoint; RENi family member	intra-S DNA damage checkpoint|double-strand break repair via homologous recombination|chromatin silencing at silent mating-type cassette|mitotic sister chromatid cohesion	molecular_function	nucleus
YMR078C	YMR078C	CTF18	hom	Verified	1.35686361893816	0.0874122742520397	no	519	0.072267877816866	313	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION	NUCLEUS|MITOCHONDRION|CHROMOSOME		Subunit of a complex with Ctf8p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion; may have overlapping functions with Rad24p in the DNA damage replication checkpoint	maintenance of DNA trinucleotide repeats|double-strand break repair via homologous recombination|DNA replication initiation|mitotic sister chromatid cohesion	molecular_function	mitochondrion|nuclear replication fork|Ctf18 RFC-like complex
YBL070C_d	YBL070C	YBL070C	hom	Dubious	1.3552070474069	0.0876757999933723	no	520	0.0956173693628837	345	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YEL045C_d	YEL045C	YEL045C	hom	Dubious	1.35324985917176	0.0879879108381316	no	521	0.122236090097359	448	NA					Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; deletion gives MMS sensitivity, growth defect under alkaline conditions, less than optimal growth upon citric acid stress	Unknown	Unknown	Unknown
YJR097W	YJR097W	JJJ3	hom	Verified	1.35058062569484	0.0884149052490774	no	522	0.097563294598053	403	NA	FT		NUCLEUS		Protein of unknown function, contains a CSL Zn finger and a DnaJ-domain; involved in diphthamide biosynthesis; ortholog human Dph4	peptidyl-diphthamide biosynthetic process from peptidyl-histidine	ferrous iron binding	nucleus|cytoplasm
YIL088C	YIL088C	AVT7	hom	Verified	1.34972160433305	0.0885526498517616	no	523	0.0676920280223341	286	NA	FT		PLASMA MEMBRANE		Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters	amino acid transport	amino acid transmembrane transporter activity	integral to membrane|plasma membrane|fungal-type vacuole
YLR267W_p	YLR267W	BOP2	hom	Uncharacterized	1.34746242198769	0.0889156741119973	no	524	0.0454245570274998	203	NA					Protein of unknown function	biological_process	molecular_function	cellular_component
YGL013C	YGL013C	PDR1	hom	Verified	1.3460956004619	0.0891358436653909	no	525	0.207148376545972	775	NA	FF|FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS	RSC COMPLEX	Transcription factor that regulates the pleiotropic drug response; zinc cluster protein that is a master regulator involved in recruiting other zinc cluster proteins to pleiotropic drug response elements (PDREs) to fine tune the regulation of multidrug resistance genes; PDR1 has a paralog, PDR3, that arose from the whole genome duplication	Unknown|positive regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YLR062C_d	YLR062C	BUD28	hom	Dubious	1.34088127599952	0.0899795011670537	no	526	0.108569365889265	361	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene RPL22A; diploid mutant displays a weak budding pattern phenotype in a systematic assay	Unknown	Unknown	Unknown
YLR394W	YLR394W	CST9	hom	Verified	1.33659078789232	0.0906781238326589	no	527	0.0858932784153379	312	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		SUMO E3 ligase; required for synaptonemal complex formation; localizes to synapsis initiation sites on meiotic chromosomes; potential Cdc28p substrate	synaptonemal complex assembly|protein sumoylation|synapsis|reciprocal meiotic recombination	SUMO ligase activity	condensed nuclear chromosome|nuclear chromosome
YJR055W	YJR055W	HIT1	hom	Verified	1.3356595342084	0.0908302907407191	no	528	0.0655747971125495	312	NA	FT		NUCLEUS		Protein of unknown function, required for growth at high temperature	biological_process	molecular_function	nucleus|cytoplasm
YDL032W_d	YDL032W	YDL032W	hom	Dubious	1.3304638371859	0.091682746811728	no	529	0.117170427931815	439	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene SLM3/YDL033C; YDL032W is not an essential gene	Unknown	Unknown	Unknown
YJL188C_d	YJL188C	BUD19	hom	Dubious	1.33015556942408	0.0917335098389164	no	530	0.0796314179096603	356	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 88% of ORF overlaps the verified gene RPL39; diploid mutant displays a weak budding pattern phenotype in a systematic assay	Unknown	Unknown	Unknown
YHR104W	YHR104W	GRE3	hom	Verified	1.33001700841446	0.0917563337206154	no	531	0.088922585102828	403	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		Aldose reductase; involved in methylglyoxal, d-xylose, arabinose, and galactose metabolism; stress induced (osmotic, ionic, oxidative, heat shock, starvation and heavy metals); regulated by the HOG pathway; protein abundance increases in response to DNA replication stress	galactose catabolic process|cellular response to oxidative stress|arabinose catabolic process|D-xylose catabolic process|response to stress	D-xylose:NADP reductase activity|mRNA binding|glucose 1-dehydrogenase (NADP+) activity|alditol:NADP+ 1-oxidoreductase activity	nucleus|cytoplasm
YOR229W	YOR229W	WTM2	hom	Verified	1.32983542917152	0.0917862499688728	no	532	0.0879061567145752	362	NA	FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|CELL CYCLE|RESPONSE TO DNA DAMAGE|GENE SILENCING	NUCLEUS		Transcriptional modulator involved in regulation of meiosis, silencing, and expression of RNR genes; involved in response to replication stress; contains WD repeats	negative regulation of chromatin silencing at silent mating-type cassette|negative regulation of transcription from RNA polymerase II promoter during meiosis|cellular protein complex localization|negative regulation of chromatin silencing at telomere|response to DNA damage stimulus|positive regulation of transcription from RNA polymerase II promoter	protein binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|transcription corepressor activity	nucleus
YPR109W_p	YPR109W	YPR109W	hom	Uncharacterized	1.32888568291778	0.0919428439893228	no	533	0.108451683142131	397	NA	FT	CELL CYCLE			Predicted membrane protein; dipoid deletion strain has high budding index	biological_process	molecular_function	cellular_component
YGL236C	YGL236C	MTO1	hom	Verified	1.3274215699252	0.092184634182459	no	534	0.107923362578698	402	NA	FT	RNA PROCESSING|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial protein, forms a heterodimer complex with Mss1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; required for respiration in paromomycin-resistant 15S rRNA mutants	mitochondrial tRNA wobble uridine modification	molecular_function	mitochondrion
YLR398C	YLR398C	SKI2	hom	Verified	1.32175899385581	0.0931242085488725	no	535	0.100252451461366	377	NA	FT	TRANSLATION			Ski complex component and putative RNA helicase, mediates 3'-5' RNA degradation by the cytoplasmic exosome; null mutants have superkiller phenotype of increased viral dsRNAs and are synthetic lethal with mutations in 5'-3' mRNA decay	nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'|nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay|nuclear-transcribed mRNA catabolic process, non-stop decay	RNA helicase activity	Ski complex
YDR369C	YDR369C	XRS2	hom	Verified	1.3152166938753	0.094218543107022	no	536	0.10725955486617	469	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS		Protein required for DNA repair; component of the Mre11 complex, which is involved in double strand breaks, meiotic recombination, telomere maintenance, and checkpoint signaling	double-strand break repair via nonhomologous end joining|meiotic DNA double-strand break formation|base-excision repair|telomere maintenance|sporulation resulting in formation of a cellular spore|double-strand break repair via break-induced replication	single-stranded telomeric DNA binding|protein binding, bridging|DNA binding|double-stranded telomeric DNA binding|telomeric DNA binding|G-quadruplex DNA binding	nucleus|Mre11 complex
YOL014W_p	YOL014W	YOL014W	hom	Uncharacterized	1.30572278494559	0.0958234233189789	no	537	0.115922986255407	419	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YHL031C	YHL031C	GOS1	hom	Verified	1.30536014642802	0.0958851211471249	no	538	0.168839396268026	625	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		v-SNARE protein involved in Golgi transport, homolog of the mammalian protein GOS-28/GS28	Golgi vesicle transport|vesicle fusion	SNAP receptor activity	SNARE complex|integral to membrane|Golgi medial cisterna
YAL019W	YAL019W	FUN30	hom	Verified	1.30516431233242	0.0959184517031287	no	539	0.0908006025721106	372	NA	FT	CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS|MITOCHONDRION|CHROMOSOME		Snf2p family member with ATP-dependent chromatin remodeling activity; has a role in silencing at the mating type locus, telomeres and centromeres; enriched at centromeres and is required for correct chromatin structure around centromeres, as well as at the boundary element of the silent HMR; recruited to DNA double-strand breaks (DSBs) where it promotes 5' strand resection of DSBs; potential Cdc28p substrate	chromosome organization|chromatin silencing at rDNA|heterochromatin maintenance involved in chromatin silencing|chromatin silencing at telomere|chromatin silencing at silent mating-type cassette|heterochromatin assembly involved in chromatin silencing	chromatin binding|DNA-dependent ATPase activity|DNA binding|protein homodimerization activity	mitochondrion|mating-type region heterochromatin|nucleus
YNL300W_p	YNL300W	TOS6	hom	Uncharacterized	1.30361956512676	0.0961816632123762	no	540	0.115059594571275	465	NA					Glycosylphosphatidylinositol-dependent cell wall protein, expression is periodic and decreases in respone to ergosterol perturbation or upon entry into stationary phase; depletion increases resistance to lactic acid	biological_process	molecular_function	fungal-type cell wall
YML011C	YML011C	RAD33	hom	Verified	1.29918390463784	0.0969404118962661	no	541	0.0830883367117562	339	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		Protein involved in nucleotide excision repair; green fluorescent protein (GFP)-fusion protein localizes to the nucleus	nucleotide-excision repair	molecular_function	nucleus
YPR099C_d	YPR099C	YPR099C	hom	Dubious	1.29675888185636	0.0973570812387151	no	542	0.103216469897926	400	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene MRPL51/YPR100W	Unknown	Unknown	Unknown
YPL199C_p	YPL199C	YPL199C	hom	Uncharacterized	1.29611238914782	0.0974683836274225	no	543	0.0985305969265199	378	NA					Putative protein of unknown function, predicted to be palmitoylated	biological_process	molecular_function	cytoplasm
YKL011C	YKL011C	CCE1	hom	Verified	1.29490005387019	0.0976773549611654	no	544	0.106877656462118	438	NA	FT	MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial cruciform cutting endonuclease, cleaves Holliday junctions formed during recombination of mitochondrial DNA	mitochondrial genome maintenance	endodeoxyribonuclease activity	mitochondrial inner membrane
YGR281W	YGR281W	YOR1	hom	Verified	1.29209835455557	0.0981615428354747	no	545	0.113766801822715	446	NA	FT	NUCLEOTIDE METABOLISM	PLASMA MEMBRANE		Plasma membrane ATP-binding cassette (ABC) transporter, multidrug transporter mediates export of many different organic anions including oligomycin; similar to human cystic fibrosis transmembrane receptor (CFTR)	transport|response to drug	xenobiotic-transporting ATPase activity	integral to membrane|plasma membrane
YOR067C	YOR067C	ALG8	hom	Verified	1.29139148555352	0.0982839807857317	no	546	0.143062395629572	552	NA	FF|FT	LIPID METABOLISM|CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Glucosyl transferase, involved in N-linked glycosylation; adds glucose to the dolichol-linked oligosaccharide precursor prior to transfer to protein during lipid-linked oligosaccharide biosynthesis; similar to Alg6p	oligosaccharide-lipid intermediate biosynthetic process|protein N-linked glycosylation	dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity	integral to membrane|endoplasmic reticulum membrane
YDL071C_d	YDL071C	YDL071C	hom	Dubious	1.29082258293542	0.0983826025591179	no	547	0.121982366639774	446	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF BDF2/YDL070W	Unknown	Unknown	Unknown
YDR378C	YDR378C	LSM6	hom	Verified	1.28883296355245	0.0987280817348444	no	548	0.111809949512241	473	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA	nuclear-transcribed mRNA catabolic process|mRNA splicing, via spliceosome|maturation of SSU-rRNA	RNA binding	U6 snRNP|nucleolus|small nucleolar ribonucleoprotein complex|U4/U6 x U5 tri-snRNP complex|cytoplasmic mRNA processing body
YIL160C	YIL160C	POT1	hom	Verified	1.28691222879853	0.0990624412250675	no	549	0.0886420203727005	314	NA	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS			3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids	fatty acid beta-oxidation	mRNA binding|acetyl-CoA C-acyltransferase activity	peroxisomal matrix|peroxisome
YKR029C	YKR029C	SET3	hom	Verified	1.28561597485976	0.0992885593729509	no	550	0.104068620989582	410	NA	FT	CELL CYCLE|CHROMATIN ORGANIZATION	NUCLEUS|CHROMOSOME		Defining member of the SET3 histone deacetylase complex which is a meiosis-specific repressor of sporulation genes; necessary for efficient transcription by RNAPII; one of two yeast proteins that contains both SET and PHD domains; SET3 has a paralog, SET4, that arose from the whole genome duplication	negative regulation of meiosis|regulation of transcription, DNA-dependent|histone deacetylation	methylated histone residue binding	Rpd3L-Expanded complex|Set3 complex
YKR039W	YKR039W	GAP1	hom	Verified	1.28416802451561	0.0995415853293364	no	551	0.0998372547340272	332	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	PLASMA MEMBRANE		General amino acid permease; Gap1p senses the presence of amino acid substrates to regulate localization to the plasma membrane when needed; essential for invasive growth	amino acid transport|gamma-aminobutyric acid transport|ammonia assimilation cycle|polyamine transport	amino acid transmembrane transporter activity|polyamine transmembrane transporter activity|L-proline transmembrane transporter activity	endosome|fungal-type vacuole lumen|integral to membrane|plasma membrane|ER to Golgi transport vesicle|integral to plasma membrane|multivesicular body
YEL062W	YEL062W	NPR2	hom	Verified	1.28250023454236	0.0998336113638066	no	552	0.116014703494096	436	NA	FT	SIGNALING|RESPONSE TO NUTRIENT LEVELS			Subunit of SEA (Seh1-associated), Npr2/3, and Iml1p complexes; Npr2/3 complex mediates downregulation of TORC1 activity upon amino acid limitation; SEA complex is a coatomer-related complex that associates dynamically with the vacuole; Iml1p complex (Iml1p-Npr2p-Npr3p) is required for non-nitrogen-starvation (NNS)-induced autophagy; Iml1p interacts primarily with phosphorylated Npr2p; homolog of human NPRL2; target of Grr1p; required for growth on urea and proline	proline transport|urea transport|regulation of TOR signaling cascade|cellular response to amino acid starvation|response to drug|cellular response to nitrogen starvation	molecular_function	Seh1-associated complex|extrinsic to fungal-type vacuolar membrane
YER093C-A	YER093C-A	AIM11	hom	Verified	1.28008701723378	0.100257267049648	no	553	0.0917338224763676	404	NA					Protein of unknown function; null mutant is viable but shows increased loss of mitochondrial genome and synthetic interaction with prohibitin (phb1); contains an intron; YER093C-A has a paralog, YBL059W, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YCR061W_p	YCR061W	YCR061W	hom	Uncharacterized	1.279188317752	0.100415374348034	no	554	0.105143249656721	441	NA					Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; induced by treatment with 8-methoxypsoralen and UVA irradiation	regulation of cell size	molecular_function	integral to membrane|cytoplasm
YML124C	YML124C	TUB3	hom	Verified	1.27381927412262	0.101363736388788	no	555	0.177717043848607	679	NA	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|NUCLEOTIDE METABOLISM|CHROMOSOME SEGREGATION	NUCLEUS|CYTOSKELETON		Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; expressed at lower level than Tub1p; TUB3 has a paralog, TUB1, that arose from the whole genome duplication	nuclear migration along microtubule|nuclear migration involved in conjugation with cellular fusion|homologous chromosome segregation|mitotic sister chromatid segregation	structural constituent of cytoskeleton	tubulin complex|cytoplasmic microtubule|kinetochore microtubule|nuclear microtubule|spindle pole body|polar microtubule
YNL271C	YNL271C	BNI1	hom	Verified	1.2734832701782	0.101423302725095	no	556	0.152180803398758	598	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON		Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNR1	barbed-end actin filament capping|actin nucleation|actin filament bundle assembly involved in cytokinetic actomyosin contractile ring assembly|establishment of mitotic spindle orientation|formin-nucleated actin cable assembly	profilin binding	incipient cellular bud site|actin filament|polarisome|plasma membrane|cellular bud neck|mating projection tip|cellular bud tip
YGL152C_d	YGL152C	YGL152C	hom	Dubious	1.27321534943596	0.101470817629328	no	557	0.113765963045852	343	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF PEX14/YGL153W	Unknown	Unknown	Unknown
YMR069W	YMR069W	NAT4	hom	Verified	1.27227428622359	0.101637840727802	no	558	0.121729127579231	413	NA	FT	CHROMATIN ORGANIZATION	NUCLEUS		N alpha-acetyl-transferase, involved in acetylation of the N-terminal residues of histones H4 and H2A	histone acetylation	histone acetyltransferase activity	nucleus|cytoplasm
YHR075C	YHR075C	PPE1	hom	Verified	1.27129964091815	0.101811035024467	no	559	0.0982780060337003	384	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Protein with carboxyl methyl esterase activity that may have a role in demethylation of the phosphoprotein phosphatase catalytic subunit; also identified as a small subunit mitochondrial ribosomal protein	cellular protein modification process|mitochondrial translation	structural constituent of ribosome|carboxylesterase activity	mitochondrial small ribosomal subunit
YIL123W	YIL123W	SIM1	hom	Verified	1.26953901606449	0.102124442118853	no	560	0.0936245357863773	388	NA	FT	CELL WALL ORG/BIOGENESIS			Protein of the SUN family (Sim1p, Uth1p, Nca3p, Sun4p) that may participate in DNA replication, promoter contains SCB regulation box at -300 bp indicating that expression may be cell cycle-regulated	fungal-type cell wall organization	molecular_function	fungal-type cell wall
YDR424C	YDR424C	DYN2	hom	Verified	1.26906944453143	0.102208148524451	no	561	0.104425233814974	418	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS	ENDOMEMBRANE SYSTEM|NUCLEUS|CYTOSKELETON		Cytoplasmic light chain dynein, microtubule motor protein; proposed to be involved in the assembly of the nuclear pore complex	microtubule-based process|actin filament-based process|nuclear pore complex assembly	molecular_function	cytoplasmic dynein complex|cytoplasmic microtubule|peroxisome|nuclear pore
YDR519W	YDR519W	FPR2	hom	Verified	1.26476309845034	0.102978131620458	no	562	0.13060310627053	469	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Membrane-bound peptidyl-prolyl cis-trans isomerase (PPIase); binds to the drugs FK506 and rapamycin; expression pattern suggests possible involvement in ER protein trafficking; relocalizes from nucleus to vacuole upon DNA replication stress	biological_process	FK506 binding|peptidyl-prolyl cis-trans isomerase activity	endoplasmic reticulum membrane
YJR061W_p	YJR061W	YJR061W	hom	Uncharacterized	1.26351380203024	0.103202294808109	no	563	0.105263361957578	429	NA					Putative protein of unknown function; non-essential gene; transcription repressed by Rm101p; YJR061W has a paralog, MNN4, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YNL034W_p	YNL034W	YNL034W	hom	Uncharacterized	1.26062137501407	0.10372264685778	no	564	0.0947479773931289	380	NA					Putative protein of unknown function; YNL034W is not an essential gene	biological_process	molecular_function	cellular_component
YGL191W	YGL191W	COX13	hom	Verified	1.2591700523906	0.103984458019583	no	565	0.0867594685697996	365	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Subunit VIa of cytochrome c oxidase; present in a subclass of cytochrome c oxidase complexes that may have a role in mimimizing generation of reactive oxygen species; not essential for cytochrome c oxidase activity but may modulate activity in response to ATP; required for assembly of Rcf2p into cytochrome c oxidase - cytochrome bc1 supercomplexes	mitochondrial respiratory chain supercomplex assembly|aerobic respiration	enzyme regulator activity|cytochrome-c oxidase activity	mitochondrion|integral to membrane|mitochondrial respiratory chain complex IV
YOL107W_p	YOL107W	YOL107W	hom	Uncharacterized	1.25829641183116	0.104142289177744	no	566	0.0936301348861595	389	NA	FT		ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and colocalizes in a punctate pattern with the early golgi/COPI vesicles; YOL107W is not an essential protein	biological_process	molecular_function	COPI-coated vesicle|Golgi apparatus
YIL131C	YIL131C	FKH1	hom	Verified	1.25669586514782	0.104431892979096	no	567	0.10540610969349	384	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|RNA PROCESSING|CHROMATIN ORGANIZATION|MITOCHONDRION ORGANIZATION|GENE SILENCING	NUCLEUS|CHROMOSOME		Forkhead family transcription factor; has a minor role in the expression of G2/M phase genes; negatively regulates transcriptional elongation; positive role in chromatin silencing at HML and HMR; binds to the recombination enhancer near HML, and regulates donor preference during mating-type switching by positioning HML near the MAT locus through FHA-domain mediated interactions with proteins near the DSB; FKH1 has a paralog, FKH2, that arose from the whole genome duplication	mRNA 3'-end processing|termination of RNA polymerase II transcription|donor selection|negative regulation of transcription involved in G1 phase of mitotic cell cycle|positive regulation of transcription involved in G2/M-phase of mitotic cell cycle|cellular response to methylmercury|positive regulation of chromatin silencing at silent mating-type cassette|negative regulation of transcription elongation from RNA polymerase II promoter|Unknown|negative regulation of transcription involved in G2/M-phase of mitotic cell cycle|chromatin remodeling	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|centromeric DNA binding	nucleus
YIL167W	YIL167W	SDL1	hom	pseudogene	1.25548148128359	0.104652013285533	no	568	0.106269574762413	418	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Open reading frame, unlikely to produce a functional protein in S288C; in closely related species and other <i>S. cerevisiae</i> strain backgrounds YIL167W and adjacent ORF, YIL168W, constitute a single ORF encoding L-serine dehydratase	serine family amino acid metabolic process	L-serine ammonia-lyase activity	cellular_component
YDR512C	YDR512C	EMI1	hom	Verified	1.25221000336134	0.105246675938491	no	569	0.105607451461541	401	NA	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|MITOCHONDRION ORGANIZATION			Non-essential protein required for transcriptional induction of the early meiotic-specific transcription factor IME1, also required for sporulation; contains twin cysteine-x9-cysteine motifs	ascospore formation|mitochondrial respiratory chain complex assembly|positive regulation of transcription from RNA polymerase II promoter	molecular_function	cellular_component
YPL259C	YPL259C	APM1	hom	Verified	1.25164206252582	0.105350160178318	no	570	0.135473553326672	506	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Mu1-like medium subunit of the clathrin-associated protein complex (AP-1); binds clathrin; involved in clathrin-dependent Golgi protein sorting	Golgi to vacuole transport|vesicle-mediated transport	clathrin binding	AP-1 adaptor complex
YER071C_p	YER071C	TDA2	hom	Uncharacterized	1.25128930294537	0.10541447338758	no	571	0.0907685710758063	289	NA	FT		SITE OF POLARIZED GROWTH		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; null mutant is sensitive to expression of the top1-T722A allele	biological_process	molecular_function	mating projection tip|cytoplasm
YBR182C-A_p	YBR182C-A	YBR182C-A	hom	Uncharacterized	1.24920307647875	0.105795403526597	no	572	0.114871692886831	440	NA					Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching	biological_process	molecular_function	cellular_component
YNR065C_p	YNR065C	YNR065C	hom	Uncharacterized	1.24633711290807	0.106320329080391	no	573	0.101423161300621	405	NA					Protein of unknown function; protein-protein interactions suggest a possible role in actin patch formation; YNR065C is not an essential gene	biological_process	molecular_function	integral to membrane
YGR081C	YGR081C	SLX9	hom	Verified	1.24505767086744	0.1065552760587	no	574	0.126508570377762	479	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Protein required for pre-rRNA processing; associated with the 90S pre-ribosome and 43S small ribosomal subunit precursor; interacts with U3 snoRNA; deletion mutant has synthetic fitness defect with an sgs1 deletion mutant	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	molecular_function	preribosome, small subunit precursor|nucleolus|nucleus|90S preribosome
YLR148W	YLR148W	PEP3	hom	Verified	1.24352463746672	0.106837283920358	no	575	0.179458047445623	648	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT			Component of CORVET tethering complex; vacuolar peripheral membrane protein that promotes vesicular docking/fusion reactions in conjunction with SNARE proteins, required for vacuolar biogenesis	regulation of SNARE complex assembly|regulation of vacuole fusion, non-autophagic|vacuole fusion, non-autophagic|late endosome to vacuole transport|vesicle docking involved in exocytosis|Golgi to endosome transport	phosphatidylinositol binding|protein binding, bridging	fungal-type vacuole membrane|HOPS complex|proteasome storage granule|CORVET complex|extrinsic to vacuolar membrane
YLR425W	YLR425W	TUS1	hom	Verified	1.24342303591651	0.106855992957349	no	576	0.155100901411495	594	NA	FT	SIGNALING|CELL WALL ORG/BIOGENESIS	SITE OF POLARIZED GROWTH		Guanine nucleotide exchange factor (GEF) that modulate Rho1p activity; involved in the cell integrity signaling pathway; interacts with Rgl1p; localization of Tus1p to the bed neck is regulated by Rgl1p; multicopy suppressor of tor2 mutation and ypk1 ypk2 double mutation; potential Cdc28p substrate	fungal-type cell wall organization|signal transduction	Rho guanyl-nucleotide exchange factor activity	incipient cellular bud site|cellular bud neck
YIL137C	YIL137C	TMA108	hom	Verified	1.24193148014764	0.107130922024791	no	577	0.101241102396465	410	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|PROTEOLYSIS			Protein that associates with ribosomes and is involved in ribosome biogenesis; putative metalloprotease	ribosome biogenesis	molecular_function	ribosome|cytoplasm
YMR162C	YMR162C	DNF3	hom	Verified	1.23896602534891	0.107679040138053	no	578	0.0926631436249317	317	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS	GOLGI APPARATUS		Aminophospholipid translocase (flippase) that maintains membrane lipid asymmetry in post-Golgi secretory vesicles; localizes to the trans-Golgi network; likely involved in protein transport; type 4 P-type ATPase	intracellular protein transport|phospholipid translocation	phospholipid-translocating ATPase activity	trans-Golgi network transport vesicle|integral to membrane
YML129C	YML129C	COX14	hom	Verified	1.23663497736728	0.108111314191316	no	579	0.116784332709674	417	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial membrane protein, involved in translational regulation of Cox1p and assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes	mitochondrial respiratory chain complex IV assembly|negative regulation of mitochondrial translation	molecular_function	mitochondrial envelope|mitochondrion|integral to membrane|mitochondrial inner membrane|mitochondrial matrix|extrinsic to membrane
YGL012W	YGL012W	ERG4	hom	Verified	1.23543749105388	0.10833386348286	no	580	0.230055615369103	845	NA	FF|FT	LIPID METABOLISM|OXIDATION-REDUCTION PROCESS	ENDOPLASMIC RETICULUM		C-24(28) sterol reductase, catalyzes the final step in ergosterol biosynthesis; mutants are viable, but lack ergosterol	ergosterol biosynthetic process	delta24(24-1) sterol reductase activity	integral to membrane|endoplasmic reticulum
YBR046C	YBR046C	ZTA1	hom	Verified	1.23451701918792	0.108505154422359	no	581	0.112225222408996	398	NA	FT	OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		NADPH-dependent quinone reductase, GFP-tagged protein localizes to the cytoplasm and nucleus; has similarity to E. coli quinone oxidoreductase and to human zeta-crystallin	cellular response to oxidative stress	NADPH:quinone reductase activity|AU-rich element binding|2-alkenal reductase [NAD(P)] activity	nucleus|cytoplasm
YEL064C	YEL064C	AVT2	hom	Verified	1.23392718452932	0.108615019344864	no	582	0.082105624563035	338	NA	FT		ENDOPLASMIC RETICULUM		Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters	transport	transporter activity	integral to membrane|endoplasmic reticulum
YPR083W	YPR083W	MDM36	hom	Verified	1.2334801268345	0.108698343357418	no	583	0.113238900906569	400	NA	FT	MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial protein required for normal mitochondrial morphology and inheritance; proposed involvement in the formation of Dnm1p and Num1p-containing cortical anchor complexes that promote mitochondrial fission	mitochondrial fission|mitochondrion organization	molecular_function	mitochondrion|cytoplasm
YMR294W	YMR294W	JNM1	hom	Verified	1.23326999034579	0.108737525132449	no	584	0.141667626114541	577	NA	FF|FT	CELL CYCLE|CYTOSKELETON ORGANIZATION	CYTOSKELETON		Component of the yeast dynactin complex, consisting of Nip100p, Jnm1p, and Arp1p; required for proper nuclear migration and spindle partitioning during mitotic anaphase B	nuclear migration|establishment of mitotic spindle orientation	structural constituent of cytoskeleton	dynactin complex|cell cortex|spindle pole body|astral microtubule
YML087C	YML087C	AIM33	hom	Verified	1.2327497265673	0.108834576535494	no	585	0.10076832750565	345	NA	FT	OXIDATION-REDUCTION PROCESS			Putative protein of unknown function, highly conserved across species; homolog of human CYB5R4; null mutant displays reduced frequency of mitochondrial genome loss; AIM33 has a paralog, PGA3, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YNL274C	YNL274C	GOR1	hom	Verified	1.23185112873402	0.109002350042573	no	586	0.0860350263012174	298	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS	NUCLEUS|MITOCHONDRION		Glyoxylate reductase; null mutation results in increased biomass after diauxic shift; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress	glyoxylate catabolic process|metabolic process	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|glyoxylate reductase activity	mitochondrion|nucleus|cytoplasm
YOR055W_d	YOR055W	YOR055W	hom	Dubious	1.22991926404847	0.109363669805926	no	587	0.0932903582331369	390	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YIL156W	YIL156W	UBP7	hom	Verified	1.22887279035791	0.10955975232679	no	588	0.112522989554988	380	NA	FT	PROTEOLYSIS			Ubiquitin-specific protease that cleaves ubiquitin-protein fusions	protein deubiquitination	ubiquitin-specific protease activity	cytoplasm
YOR367W	YOR367W	SCP1	hom	Verified	1.22720284581066	0.109873180049564	no	589	0.128325522222493	501	NA	FT	CYTOSKELETON ORGANIZATION	CYTOSKELETON		Component of yeast cortical actin cytoskeleton, binds and cross links actin filaments; originally identified by its homology to calponin (contains a calponin-like repeat) but the Scp1p domain structure is more similar to transgelin	actin filament organization|chronological cell aging	actin filament binding|protein binding, bridging	actin cortical patch
YHR147C	YHR147C	MRPL6	hom	Verified	1.22714633852982	0.109883797004244	no	590	0.131807706172	484	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YBR159W	YBR159W	IFA38	hom	Verified	1.22576031566107	0.110144442519435	no	591	0.110477734426655	441	NA	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Microsomal beta-keto-reductase; contains oleate response element (ORE) sequence in the promoter region; mutants exhibit reduced VLCFA synthesis, accumulate high levels of dihydrosphingosine, phytosphingosine and medium-chain ceramides	fatty acid elongation	ketoreductase activity	integral to membrane|endoplasmic reticulum
YFR033C	YFR033C	QCR6	hom	Verified	1.2253386266866	0.110223830242293	no	592	0.108631937987675	425	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Subunit 6 of the ubiquinol cytochrome-c reductase complex; the complex, also known as the cytochrome bc(1) complex or Complex III, is a component of the mitochondrial inner membrane electron transport chain; highly acidic protein; required for maturation of cytochrome c1; may be loosely associated with the complex since it is easily released into the intermembrane space	mitochondrial electron transport, ubiquinol to cytochrome c|aerobic respiration	ubiquinol-cytochrome-c reductase activity	mitochondrion|integral to membrane|mitochondrial respiratory chain complex III
YNL012W	YNL012W	SPO1	hom	Verified	1.2228234705115	0.110698189313664	no	593	0.0916607052571086	375	NA	FT	CELL CYCLE|LIPID METABOLISM|MEMBRANE ORGANIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM		Meiosis-specific prospore protein; required for meiotic spindle pole body duplication and separation; required to produce bending force necessary for proper prospore membrane assembly during sporulation; has similarity to phospholipase B	meiosis|spore membrane bending pathway	phospholipase activity	endoplasmic reticulum|nucleus|prospore membrane
YLR306W	YLR306W	UBC12	hom	Verified	1.22156204263721	0.110936645007813	no	594	0.0942451287280545	359	NA					Enzyme that mediates the conjugation of Rub1p, a ubiquitin-like protein, to other proteins; related to E2 ubiquitin-conjugating enzymes	protein neddylation	NEDD8 ligase activity	cellular_component
YNL212W	YNL212W	VID27	hom	Verified	1.22125132954012	0.110995437507556	no	595	0.109415239654685	427	NA					Cytoplasmic protein of unknown function; possibly involved in vacuolar protein degradation; not essential for proteasome-dependent degradation of fructose-1,6-bisphosphatase (FBPase); null mutants exhibit normal growth	biological_process	molecular_function	cytoplasm
YKL032C	YKL032C	IXR1	hom	Verified	1.21975966413828	0.111277998144724	no	596	0.142548295891193	528	NA	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Protein that binds DNA containing intrastrand cross-links formed by cisplatin, contains two HMG (high mobility group box) domains, which confer the ability to bend cisplatin-modified DNA; mediates aerobic transcriptional repression of COX5b	DNA repair|cellular response to hypoxia|negative regulation of transcription from RNA polymerase II promoter	damaged DNA binding|sequence-specific DNA binding	nuclear chromatin
YBL086C_p	YBL086C	YBL086C	hom	Uncharacterized	1.21816098898235	0.111581400526555	no	597	0.0925774361764077	297	NA					Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery	biological_process	molecular_function	cellular_component
YHL023C	YHL023C	NPR3	hom	Verified	1.21650752348894	0.111895823409049	no	598	0.124017788606896	463	NA	FT	CELL CYCLE|SIGNALING|RESPONSE TO NUTRIENT LEVELS			Subunit of SEA (Seh1-associated), Npr2/3, and Iml1p complexes; Npr2/3 complex mediates downregulation of TORC1 activity upon amino acid limitation; SEA complex is a coatomer-related complex that associates dynamically with the vacuole; Iml1p complex (Iml1p-Npr2p-Npr3p) is required for non-nitrogen-starvation (NNS)-induced autophagy; required for Npr2p phosphorylation and Iml1p-Npr2p interaction; null mutant shows delayed meiotic DNA replication and double-strand break repair	meiosis|regulation of TOR signaling cascade|cellular response to amino acid starvation	molecular_function	Seh1-associated complex|extrinsic to fungal-type vacuolar membrane
YKL055C	YKL055C	OAR1	hom	Verified	1.21215730077501	0.112726086442889	no	599	0.138909992419774	570	NA	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Mitochondrial 3-oxoacyl-[acyl-carrier-protein] reductase, may comprise a type II mitochondrial fatty acid synthase along with Mct1p	fatty acid metabolic process|aerobic respiration	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity	mitochondrion
YNL283C	YNL283C	WSC2	hom	Verified	1.21208914674737	0.112739128905225	no	600	0.144228033473823	558	NA	FF|FT	SIGNALING|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Partially redundant sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway involved in maintenance of cell wall integrity and recovery from heat shock; secretory pathway Wsc2p is required for the arrest of secretion response	fungal-type cell wall organization|response to heat|Rho protein signal transduction	transmembrane signaling receptor activity	site of polarized growth|cellular bud|mating projection tip|cytoplasm
YDR300C	YDR300C	PRO1	hom	Verified	1.21068535271678	0.113008009082502	no	601	0.116991262527558	411	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Gamma-glutamyl kinase; catalyzes the first step in proline biosynthesis; PRO1 has a paralog, YHR033W, that arose from the whole genome duplication	proline biosynthetic process	glutamate 5-kinase activity	cytoplasm
YPR044C_d	YPR044C	OPI11	hom	Dubious	1.20940606012079	0.113253440791488	no	602	0.111956778967028	416	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene RPL43A/YPR043W; deletion confers sensitivity to GSAO	Unknown	Unknown	Unknown
YBR048W	YBR048W	RPS11B	hom	Verified	1.20817445486948	0.113490082739878	no	603	0.123602280419373	474	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S11 and bacterial S17; RPS11B has a paralog, RPS11A, that arose from the whole genome duplication	cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|ribosomal small subunit assembly	structural constituent of ribosome	cytosolic small ribosomal subunit|90S preribosome
YJL110C	YJL110C	GZF3	hom	Verified	1.20331774923029	0.114426691562499	no	604	0.124879109157382	435	NA	FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		GATA zinc finger protein; negatively regulates nitrogen catabolic gene expression by competing with Gat1p for GATA site binding; function requires a repressive carbon source; dimerizes with Dal80p and binds to Tor1p; GZF3 has a paralog, DAL80, that arose from the whole genome duplication	maintenance of protein location in nucleus|nitrogen catabolite repression of transcription|negative regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding RNA polymerase II transcription factor activity|sequence-specific DNA binding	nucleus
YNL201C	YNL201C	PSY2	hom	Verified	1.20331555269902	0.114427116401676	no	605	0.136411392988447	500	NA	FT	CELL CYCLE|SIGNALING|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Subunit of protein phosphatase PP4 complex; active complex is composed of catalytic subunit Pph3p and Psy2p, with Psy4p apparently providing additional substrate specificity in some cases; regulates recovery from the DNA damage checkpoint and also the gene conversion- and single-strand annealing-mediated pathways of meiotic double-strand break repair; Pph3p and Psy2p localize to foci on meiotic chromosomes; putative homolog of mammalian R3	Unknown|response to DNA damage stimulus|protein dephosphorylation|signal transduction involved in meiotic recombination checkpoint	protein serine/threonine phosphatase activity	condensed nuclear chromosome|nucleus
YLR414C	YLR414C	PUN1	hom	Verified	1.20293062539799	0.114501583945255	no	606	0.0832672421718676	314	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL WALL ORG/BIOGENESIS	PLASMA MEMBRANE		Plasma membrane protein with a role in cell wall integrity; co-localizes with Sur7p in punctate membrane patches; null mutant displays decreased thermotolerance; transcription induced upon cell wall damage and metal ion stress	fungal-type cell wall organization|protein oligomerization	molecular_function	integral to membrane|membrane raft|plasma membrane|cellular bud|cytoplasm
YPR095C	YPR095C	SYT1	hom	Verified	1.19981882066028	0.115104856547624	no	607	0.120633002344806	436	NA	FT	VESICLE-MEDIATED TRANSPORT|SIGNALING	MITOCHONDRION|GOLGI APPARATUS		Guanine nucleotide exchange factor (GEF) for Arf proteins; promotes activation of Arl1p, which recruits Imh1p to the Golgi; involved in vesicular transport; member of the Sec7-domain family; contains a PH domain	vesicle-mediated transport|exocytosis|positive regulation of ARF protein signal transduction	ARF guanyl-nucleotide exchange factor activity	mitochondrion|Golgi apparatus part
YPL174C	YPL174C	NIP100	hom	Verified	1.19947759598424	0.115171145595383	no	608	0.131994034118087	492	NA	FT	CELL CYCLE|CYTOSKELETON ORGANIZATION	CYTOSKELETON		Large subunit of the dynactin complex, which is involved in partitioning the mitotic spindle between mother and daughter cells; putative ortholog of mammalian p150(glued)	establishment of mitotic spindle orientation	microtubule binding	dynactin complex|cell cortex|spindle pole body|astral microtubule
YGR148C	YGR148C	RPL24B	hom	Verified	1.19902794697983	0.115258539466331	no	609	0.123516245646937	436	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L24B; not essential for translation but may be required for normal translation rate; homologous to mammalian ribosomal protein L24, no bacterial homolog; RPL24B has a paralog, RPL24A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome|RNA binding	cytosolic large ribosomal subunit
YPL086C	YPL086C	ELP3	hom	Verified	1.19813753221906	0.115431739738389	no	610	0.131255806581957	512	NA	FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|RNA PROCESSING|CHROMATIN ORGANIZATION	NUCLEUS		Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; exhibits histone acetyltransferase activity that is directed to histones H3 and H4; disruption confers resistance to K. lactis zymotoxin	regulation of transcription from RNA polymerase II promoter|tRNA wobble uridine modification	histone acetyltransferase activity	Elongator holoenzyme complex|nucleus|cytoplasm
YJL139C	YJL139C	YUR1	hom	Verified	1.19797089373217	0.115464174191825	no	611	0.119826851934244	449	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Mannosyltransferase involved in protein N-glycosylation; member of the KTR1 family; located in the Golgi apparatus; YUR1 has a paralog, KTR2, that arose from the whole genome duplication	cell wall mannoprotein biosynthetic process|protein N-linked glycosylation	mannosyltransferase activity	Golgi apparatus
YIL030C	YIL030C	SSM4	hom	Verified	1.19718986670759	0.115616279309589	no	612	0.121634000503128	471	NA	FT	PROTEOLYSIS	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM	UBIQUITIN LIGASE COMPLEX	Ubiquitin-protein ligase involved in ER-associated protein degradation; located in the ER/nuclear envelope; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation	ER-associated protein catabolic process	ubiquitin-protein ligase activity	nuclear envelope|integral to endoplasmic reticulum membrane|Doa10p ubiquitin ligase complex|integral to membrane|nuclear inner membrane
YOR089C	YOR089C	VPS21	hom	Verified	1.19635894098323	0.115778258423785	no	613	0.184412137154702	667	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING|VACUOLAR TRANSPORT	MITOCHONDRION		Rab family GTPase; required for endocytic transport and for sorting of vacuolar hydrolases; localized in endocytic intermediates; detected in mitochondria; geranylgeranylation required for membrane association; mammalian Rab5 homolog; protein abundance increases in response to DNA replication stress; VPS21 has a paralog, YPT53, that arose from the whole genome duplication	endocytosis|vacuole inheritance|protein targeting to vacuole	GTP binding|GTPase activity	mitochondrial outer membrane|late endosome|mitochondrion
YLR308W	YLR308W	CDA2	hom	Verified	1.19604264270271	0.115839959353275	no	614	0.112034364525321	432	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM			Chitin deacetylase, together with Cda1p involved in the biosynthesis ascospore wall component, chitosan; required for proper rigidity of the ascospore wall	ascospore wall assembly	chitin deacetylase activity	chitosan layer of spore wall
YBR176W	YBR176W	ECM31	hom	Verified	1.19499251887911	0.116044976518197	no	615	0.122562408655766	363	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM	MITOCHONDRION		Ketopantoate hydroxymethyltransferase, required for pantothenic acid biosynthesis, converts 2-oxoisovalerate into 2-dehydropantoate	pantothenate biosynthetic process	3-methyl-2-oxobutanoate hydroxymethyltransferase activity	mitochondrion
YMR026C	YMR026C	PEX12	hom	Verified	1.19430448325115	0.116179442275771	no	616	0.13711381362903	439	NA	FT	PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION			C3HC4-type RING-finger peroxin and E3 ubiquitin ligase, required for peroxisome biogenesis and peroxisomal matrix protein import; forms translocation subcomplex with Pex2p and Pex10p; mutations in human homolog cause peroxisomal disorder	protein import into peroxisome matrix	ubiquitin-protein ligase activity|protein binding	integral to peroxisomal membrane
YML037C_p	YML037C	YML037C	hom	Uncharacterized	1.19364971358752	0.1163075093743	no	617	0.146347771597484	509	NA					Putative protein of unknown function with some characteristics of a transcriptional activator; may be a target of Dbf2p-Mob1p kinase; GFP-fusion protein co-localizes with clathrin-coated vesicles; YML037C is not an essential gene	biological_process	molecular_function	clathrin-coated vesicle
YLL062C	YLL062C	MHT1	hom	Verified	1.19172301846034	0.116684934645904	no	618	0.111109718795918	336	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			S-methylmethionine-homocysteine methyltransferase, functions along with Sam4p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio	sulfur amino acid metabolic process	homocysteine S-methyltransferase activity	cytoplasm
YOR132W	YOR132W	VPS17	hom	Verified	1.18935591270967	0.117149820890455	no	619	0.115616161853621	473	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM		Subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde protein transport; peripheral membrane protein that assembles onto the membrane with Vps5p to promote vesicle formation; required for recruiting the retromer complex to the endosome membranes	retrograde transport, endosome to Golgi	protein transporter activity|phosphatidylinositol-3-phosphate binding	endosome|retromer complex, outer shell|retromer complex
YMR127C	YMR127C	SAS2	hom	Verified	1.18842044926955	0.117333901911564	no	620	0.10190362405526	401	NA	FT	CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS|CHROMOSOME	HISTONE ACETYLTRANSFERASE	Histone acetyltransferase (HAT) catalytic subunit of the SAS complex (Sas2p-Sas4p-Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; member of the MYSTacetyltransferase family	histone acetylation|histone exchange|chromatin silencing at telomere	acetyltransferase activity|histone acetyltransferase activity	nuclear chromatin|SAS acetyltransferase complex|nuclear chromosome, telomeric region
YKL008C	YKL008C	LAC1	hom	Verified	1.18602983219825	0.117805259302153	no	621	0.110365670732019	423	NA	FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Ceramide synthase component, involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lag1p	replicative cell aging|ceramide biosynthetic process	sphingosine N-acyltransferase activity	integral to membrane|endoplasmic reticulum
YMR201C	YMR201C	RAD14	hom	Verified	1.18543290575786	0.117923163914017	no	622	0.125553775113786	448	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		Protein that recognizes and binds damaged DNA during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); contains zinc finger motif; homolog of human XPA protein	nucleotide-excision repair, DNA damage recognition	damaged DNA binding|zinc ion binding	nucleotide-excision repair factor 1 complex|nucleus
YKR058W	YKR058W	GLG1	hom	Verified	1.18511681473188	0.117985631853091	no	623	0.10368714431269	395	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY			Glycogenin glucosyltransferase; self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; similar to mammalian glycogenin; GLG1 has a paralog, GLG2, that arose from the whole genome duplication	glycogen biosynthetic process	glycogenin glucosyltransferase activity	cellular_component
YKL110C	YKL110C	KTI12	hom	Verified	1.18201739354691	0.118599399689931	no	624	0.134288252175626	505	NA	FT	TRANSCRIPTION FROM RNA POL II|RNA PROCESSING	NUCLEUS		Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p	regulation of transcription from RNA polymerase II promoter|cell growth|tRNA wobble uridine modification	chromatin binding	nucleus|cytoplasm
YGR276C	YGR276C	RNH70	hom	Verified	1.1799786126459	0.119004360664821	no	625	0.115975437929028	415	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		3'-5' exoribonuclease; required for maturation of 3' ends of 5S rRNA and tRNA-Arg3 from dicistronic transcripts	U5 snRNA 3'-end processing|generation of mature 3'-end of 5S rRNA generated by RNA polymerase III|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|tRNA 3'-trailer cleavage, exonucleolytic	3'-5'-exoribonuclease activity|3'-5' exonuclease activity	nucleus
YBR240C	YBR240C	THI2	hom	Verified	1.17958855939611	0.119081947679928	no	626	0.140665833777216	502	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Transcriptional activator of thiamine biosynthetic genes; interacts with regulatory factor Thi3p to control expression of thiamine biosynthetic genes with respect to thiamine availability; acts together with Pdc2p to respond to thiaminediphosphate demand, possibly as related to carbon source availability; zinc finger protein of the Zn(II)2Cys6 type	thiamine biosynthetic process|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II activating transcription factor binding|RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription	nucleus
YDL066W	YDL066W	IDP1	hom	Verified	1.17828270755946	0.119341959667436	no	627	0.197792988379244	703	NA	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes	isocitrate metabolic process|glutamate biosynthetic process	isocitrate dehydrogenase (NADP+) activity	mitochondrial nucleoid|mitochondrion
YDL135C	YDL135C	RDI1	hom	Verified	1.1772500098977	0.119547866630795	no	628	0.0858061716497023	304	NA	FT	MEMBRANE ORGANIZATION|SIGNALING|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH		Rho GDP dissociation inhibitor; involved in the localization and regulation of Cdc42p and Rho1p; protein abundance increases in response to DNA replication stress	regulation of vacuole fusion, non-autophagic|actin filament organization|small GTPase mediated signal transduction	Rho GDP-dissociation inhibitor activity	cytosol|plasma membrane|cellular bud neck|cellular bud tip
YOL109W	YOL109W	ZEO1	hom	Verified	1.17662573091394	0.119672461503501	no	629	0.125956317999492	441	NA	FT	CELL WALL ORG/BIOGENESIS	MITOCHONDRION|PLASMA MEMBRANE		Peripheral membrane protein of the plasma membrane that interacts with Mid2p; regulates the cell integrity pathway mediated by Pkc1p and Slt2p; the authentic protein is detected in a phosphorylated state in highly purified mitochondria	fungal-type cell wall organization|response to stress	molecular_function	mitochondrial outer membrane|mitochondrion|extrinsic to plasma membrane|plasma membrane
YDL173W	YDL173W	PAR32	hom	Verified	1.17354338457838	0.120288984819495	no	630	0.149445490585282	539	NA					Putative protein of unknown function; hyperphosphorylated upon rapamycin treatment in a Tap42p-dependent manner; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; PAR32 is not an essential gene	biological_process	molecular_function	cytoplasm
YMR145C	YMR145C	NDE1	hom	Verified	1.1726378747706	0.120470527136041	no	631	0.117136619032166	362	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Mitochondrial external NADH dehydrogenase, a type II NAD(P)H:quinone oxidoreductase that catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p provide cytosolic NADH to the mitochondrial respiratory chain	glucose catabolic process to ethanol|NADH oxidation|chronological cell aging	NADH dehydrogenase activity	mitochondrion
YIR017C	YIR017C	MET28	hom	Verified	1.17046039467722	0.12090787172593	no	632	0.150190230872349	491	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Basic leucine zipper (bZIP) transcriptional activator in the Cbf1p-Met4p-Met28p complex, participates in the regulation of sulfur metabolism	regulation of transcription from RNA polymerase II promoter|regulation of sulfur amino acid metabolic process|Unknown	RNA polymerase II activating transcription factor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YDR237W	YDR237W	MRPL7	hom	Verified	1.17039018258365	0.12092199232076	no	633	0.139859892554407	536	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit; MRPL7 produces both YmL5 and YmL7, which are two different modified forms of the same protein	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YKL134C	YKL134C	OCT1	hom	Verified	1.16884023488593	0.121234003213964	no	634	0.123931801997619	479	NA	FT	PROTEIN LOCALIZATION|ION HOMEOSTASIS|PROTEOLYSIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS	MITOCHONDRION		Mitochondrial intermediate peptidase, cleaves destabilizing N-terminal residues of a subset of proteins upon import, after their cleavage by mitochondrial processing peptidase (Mas1p-Mas2p); may contribute to mitochondrial iron homeostasis	cellular iron ion homeostasis|protein processing involved in protein targeting to mitochondrion	metalloendopeptidase activity	mitochondrion
YNL304W	YNL304W	YPT11	hom	Verified	1.16856847321148	0.121288768253171	no	635	0.127384706797841	415	NA	FT	SIGNALING|MITOCHONDRION ORGANIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|SITE OF POLARIZED GROWTH		Rab family GTPase that interacts with the C-terminal tail domain of Myo2p; mediates distribution of mitochondria and endoplasmic reticuli to daughter cells	mitochondrion inheritance|endoplasmic reticulum inheritance|Golgi inheritance|Golgi localization	GTPase activity	incipient cellular bud site|endoplasmic reticulum|cellular bud neck|cellular bud tip
YPR067W	YPR067W	ISA2	hom	Verified	1.16477634105446	0.122054768999985	no	636	0.154054251616736	540	NA	FT	KETONE METABOLISM|COFACTOR METABOLISM	MITOCHONDRION		Protein required for maturation of mitochondrial [4Fe-4S] proteins; functions in a complex with Isa1p and possibly Iba57p; localizes to the mitochondrial intermembrane space, overexpression of ISA2 suppresses grx5 mutations	iron-sulfur cluster assembly|biotin biosynthetic process	iron ion binding	mitochondrion|mitochondrial intermembrane space
YMR031C	YMR031C	EIS1	hom	Verified	1.16236230542086	0.122544163998098	no	637	0.132355263050945	442	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS	MITOCHONDRION|PLASMA MEMBRANE		Component of the eisosome required for proper eisosome assembly; similarity to Ykl050cp and Uso1p; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; protein increases in abundance and relocalizes from plasma membrane to cytoplasm upon DNA replication stress	eisosome assembly	molecular_function	eisosome|mitochondrion|membrane raft|cytoplasm
YOL056W	YOL056W	GPM3	hom	Verified	1.15928002049567	0.123171031487684	no	638	0.118069150823731	459	NA	FT	CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY			Homolog of Gpm1p phosphoglycerate mutase, which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event	biological_process	phosphoglycerate mutase activity|molecular_function	cytosol
YER004W	YER004W	FMP52	hom	Verified	1.15773204570291	0.123486701106588	no	639	0.137728549833511	479	NA	FT		ENDOPLASMIC RETICULUM|MITOCHONDRION		Protein of unknown function, localized to the mitochondrial outer membrane; induced by treatment with 8-methoxypsoralen and UVA irradiation	biological_process	molecular_function	mitochondrial outer membrane|mitochondrion|endoplasmic reticulum
YPL158C	YPL158C	AIM44	hom	Verified	1.15575452842327	0.12389078860855	no	640	0.162783957097992	550	NA	FT		SITE OF POLARIZED GROWTH		Protein of unknown function; GFP-fusion protein localizes to the bud neck; transcription is regulated by Swi5p; null mutant displays elevated frequency of mitochondrial genome loss; relocalizes from bud neck to cytoplasm upon DNA replication stress	biological_process	molecular_function	cellular bud neck
YCL035C	YCL035C	GRX1	hom	Verified	1.15282882986126	0.124490324295674	no	641	0.108250707791627	389	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		Glutathione-dependent disulfide oxidoreductase; hydroperoxide and superoxide-radical responsive, heat-stable, with active site cysteine pair; protects cells from oxidative damage; GRX1 has a paralog, GRX2, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress	protein glutathionylation|cellular response to oxidative stress	disulfide oxidoreductase activity|glutathione transferase activity|glutathione peroxidase activity	nucleus|cytoplasm
YJL100W	YJL100W	LSB6	hom	Verified	1.15280711889822	0.124494780886871	no	642	0.136492877794369	538	NA	FT	LIPID METABOLISM	PLASMA MEMBRANE		Type II phosphatidylinositol 4-kinase that binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization	phosphatidylinositol phosphorylation	1-phosphatidylinositol 4-kinase activity	fungal-type vacuole membrane|plasma membrane|cytoplasm
YAL005C	YAL005C	SSA1	hom	Verified	1.14917420399943	0.125242077741146	no	643	0.0938300380836333	344	NA	FT	PROTEIN LOCALIZATION|TRANSLATION|MITOCHONDRION ORGANIZATION	NUCLEUS		ATPase involved in protein folding and NLS-directed nuclear transport; member of HSP70 family; forms chaperone complex with Ydj1p; localized to nucleus, cytoplasm, and cell wall; 98% identical with paralog Ssa2p, but subtle differences between the two proteins provide functional specificity with respect to propagation of yeast [URE3] prions and vacuolar-mediated degradations of gluconeogenesis enzymes; general targeting factor of Hsp104p to prion fibrils	cytoplasmic translation|protein folding|protein refolding|protein targeting to mitochondrion|SRP-dependent cotranslational protein targeting to membrane, translocation|protein import into nucleus, translocation|response to stress	unfolded protein binding|ATPase activity	fungal-type vacuole membrane|fungal-type cell wall|plasma membrane|nucleus|polysome|chaperonin-containing T-complex|cytoplasm
YDR137W	YDR137W	RGP1	hom	Verified	1.14540162656536	0.126021412428236	no	644	0.215318789850773	711	NA	FF|FT	VESICLE-MEDIATED TRANSPORT|CELL CYCLE|CELL DIVISION	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) that catalyzes nucleotide exchange on Ypt6p	retrograde transport, endosome to Golgi	guanyl-nucleotide exchange factor activity	Golgi apparatus|Ric1p-Rgp1p complex|Golgi membrane|guanyl-nucleotide exchange factor complex
YOR325W_d	YOR325W	YOR325W	hom	Dubious	1.14371379347144	0.126371175546389	no	645	0.12865237338339	516	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF FRT1	Unknown	Unknown	Unknown
YGR064W_d	YGR064W	YGR064W	hom	Dubious	1.14318188057885	0.126481541835242	no	646	0.211442883483219	699	NA	FF				Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SPT4/YGR063C	Unknown	Unknown	Unknown
YCR090C_p	YCR090C	YCR090C	hom	Uncharacterized	1.14273216648892	0.126574905114822	no	647	0.0892922471921014	389	NA	FT		NUCLEUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YCR090C is not an essential gene	biological_process	molecular_function	nucleus|cytoplasm
YOR028C	YOR028C	CIN5	hom	Verified	1.14216294019508	0.12669314864637	no	648	0.103969543586025	386	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Basic leucine zipper (bZIP) transcription factor of the yAP-1 family; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; mediates pleiotropic drug resistance and salt tolerance; nuclearly localized under oxidative stress and sequestered in the cytoplasm by Lot6p under reducing conditions; CIN5 has a paralog, YAP6, that arose from the whole genome duplication	hyperosmotic salinity response|response to drug|hyperosmotic response|regulation of transcription from RNA polymerase II promoter	repressing transcription factor binding|sequence-specific DNA binding	nucleus|cytoplasm
YHR021W-A_p	YHR021W-A	ECM12	hom	Uncharacterized	1.14171471370757	0.126786311398284	no	649	0.116925204548158	419	NA	FT	CELL WALL ORG/BIOGENESIS			Putative protein of unknown function; may contribute to cell wall biosynthesis, mutants display zymolyase hypersensitivity	fungal-type cell wall organization	molecular_function	cellular_component
YDR524C	YDR524C	AGE1	hom	Verified	1.14139944450405	0.126851867879115	no	650	0.0635731292881756	275	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING|NUCLEOTIDE METABOLISM	GOLGI APPARATUS		ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector, involved in the secretory and endocytic pathways; contains C2C2H2 cysteine/histidine motif	ER to Golgi vesicle-mediated transport|intra-Golgi vesicle-mediated transport	phospholipid binding|ARF GTPase activator activity	endosome|trans-Golgi network|cytoplasm
YDR121W	YDR121W	DPB4	hom	Verified	1.14022474176151	0.1270963411002	no	651	0.145745043124862	489	NA	FT	GENE SILENCING	NUCLEUS|CHROMOSOME		Subunit of DNA pol epsilon and of ISW2 chromatin accessibility complex; involved in both chromosomal DNA replication and inheritance of telomeric silencing; stabilizes the interaction of Pol epsilon with primer-template DNA, positively affecting the processivity of the polymerase and exonuclease activities of Pol epsilon; interacts with extranucleosomal DNA and acts as anchor point for ISW2 complex that retains its position on DNA during nucleosome mobilization	DNA-dependent DNA replication|chromatin silencing at telomere	double-stranded DNA binding|single-stranded DNA binding|DNA-directed DNA polymerase activity	chromatin accessibility complex|epsilon DNA polymerase complex
YBR028C	YBR028C	YPK3	hom	Verified	1.13752961780863	0.127658475191083	no	652	0.15595096867079	528	NA	FT	PROTEIN PHOSPHORYLATION			An AGC kinase phosphorylated by cAMP-dependent protein kinase (PKA) in a TORC1-dependent manner	biological_process	protein kinase activity	cytoplasm
YJL062W	YJL062W	LAS21	hom	Verified	1.13432343907029	0.128329450363188	no	653	0.132986991176081	547	NA	FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|PLASMA MEMBRANE		Integral plasma membrane protein involved in the synthesis of the glycosylphosphatidylinositol (GPI) core structure; mutations affect cell wall integrity	GPI anchor biosynthetic process	mannose-ethanolamine phosphotransferase activity|transferase activity	integral to endoplasmic reticulum membrane|integral to membrane|integral to plasma membrane
YKL113C	YKL113C	RAD27	hom	Verified	1.13371468997023	0.128457122819339	no	654	0.163037005733799	603	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS|MITOCHONDRION		5' to 3' exonuclease, 5' flap endonuclease, required for Okazaki fragment processing and maturation as well as for long-patch base-excision repair; member of the S. pombe RAD2/FEN1 family	double-strand break repair via nonhomologous end joining|replicative cell aging|DNA replication, removal of RNA primer|base-excision repair, base-free sugar-phosphate removal|gene conversion at mating-type locus, DNA repair synthesis	5'-3' exonuclease activity|5'-flap endonuclease activity	mitochondrion|nucleus
YMR315W	YMR315W	YMR315W	hom	Verified	1.13277392981178	0.128654601053598	no	655	0.132988630996595	483	NA	FT	OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM	NUCLEUS		Protein with NADP(H) oxidoreductase activity; transcription is regulated by Stb5p in response to NADPH depletion induced by diamide; promoter contains a putative Stb5p binding site; protein abundance increases in response to DNA replication stress	NADPH regeneration	oxidoreductase activity	nucleus|cytoplasm
YKL090W	YKL090W	CUE2	hom	Verified	1.13261581323775	0.128687812520417	no	656	0.120218825272856	469	NA					Protein of unknown function; has two CUE domains that bind ubiquitin, which may facilitate intramolecular monoubiquitination	biological_process	ubiquitin binding	cellular_component
YKR091W	YKR091W	SRL3	hom	Verified	1.12769306568451	0.129724783598257	no	657	0.133805614477161	522	NA					Cytoplasmic protein that, when overexpressed, suppresses the lethality of a rad53 null mutation; potential Cdc28p substrate	nucleobase-containing compound metabolic process	molecular_function	cytoplasm
YOR073W	YOR073W	SGO1	hom	Verified	1.12752486689836	0.129760316426466	no	658	0.148413868228581	515	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME|CYTOSKELETON	KINETOCHORE	Component of the spindle checkpoint, involved in sensing lack of tension on mitotic chromosomes; protects centromeric Rec8p at meiosis I; required for accurate chromosomal segregation at meiosis II and for mitotic chromosome stability	positive regulation of maintenance of meiotic sister chromatid cohesion|meiotic sister chromatid segregation|meiotic sister chromatid separation|sister chromatid biorientation|maintenance of meiotic sister chromatid cohesion|mitotic cell cycle spindle assembly checkpoint|mitotic sister chromatid segregation	molecular_function	condensed nuclear chromosome kinetochore|nucleus|spindle pole body|condensed nuclear chromosome, centromeric region
YNL122C_p	YNL122C	YNL122C	hom	Uncharacterized	1.12595226850213	0.130092861747388	no	659	0.123947958120852	498	NA	FT	TRANSLATION	MITOCHONDRION		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL122C is not an essential gene	biological_process	molecular_function	mitochondrion
YLR264W	YLR264W	RPS28B	hom	Verified	1.12541141075167	0.130207368978425	no	660	0.129078446174784	463	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S28, no bacterial homolog; RPS28B has a paralog, RPS28A, that arose from the whole genome duplication	cytoplasmic translation|rRNA export from nucleus	structural constituent of ribosome	cytosolic small ribosomal subunit
YDL083C	YDL083C	RPS16B	hom	Verified	1.12333093451681	0.130648485187366	no	661	0.158032490404275	510	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S16 and bacterial S9; RPS16B has a paralog, RPS16A, that arose from the whole genome duplication	cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome	cytosolic small ribosomal subunit
YLR439W	YLR439W	MRPL4	hom	Verified	1.12325390592575	0.130664837105403	no	662	0.171193193368099	579	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit, homolog of prokaryotic L29 ribosomal protein; located at the ribosomal tunnel exit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YGR279C	YGR279C	SCW4	hom	Verified	1.12161674782935	0.131012713807934	no	663	0.136067039731448	484	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM			Cell wall protein with similarity to glucanases; scw4 scw10 double mutants exhibit defects in mating	conjugation with cellular fusion	glucosidase activity	extracellular region|fungal-type cell wall
YMR282C	YMR282C	AEP2	hom	Verified	1.12034502812882	0.131283380397564	no	664	0.168925681458854	582	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial protein, likely involved in translation of the mitochondrial OLI1 mRNA; exhibits genetic interaction with the OLI1 mRNA 5'-untranslated leader	mitochondrial translational initiation	molecular_function	mitochondrion
YBR268W	YBR268W	MRPL37	hom	Verified	1.12032228796563	0.131288223814154	no	665	0.177474918283545	625	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YHR150W	YHR150W	PEX28	hom	Verified	1.11969099405749	0.131422732068626	no	666	0.116886476655466	470	NA	FT	PEROXISOME ORGANIZATION			Peroxisomal integral membrane peroxin, involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p	peroxisome organization	molecular_function	integral to membrane|peroxisomal membrane
YDR452W	YDR452W	PPN1	hom	Verified	1.11954007515051	0.131454902078463	no	667	0.173086979097789	471	NA	FT		NUCLEUS		Vacuolar endopolyphosphatase with a role in phosphate metabolism; functions as a homodimer; relocalizes from vacuole to cytoplasm upon DNA replication stress	polyphosphate catabolic process|polyphosphate metabolic process	endopolyphosphatase activity|exopolyphosphatase activity	fungal-type vacuole membrane|nucleus
YEL063C	YEL063C	CAN1	hom	Verified	1.11723413165888	0.131947115231931	no	668	0.150171388620607	558	NA	FT		MITOCHONDRION|PLASMA MEMBRANE		Plasma membrane arginine permease; requires phosphatidyl ethanolamine (PE) for localization, exclusively associated with lipid rafts; mutation confers canavanine resistance; CAN1 has a paralog, ALP1, that arose from the whole genome duplication	basic amino acid transport|transmembrane transport	basic amino acid transmembrane transporter activity|arginine transmembrane transporter activity	mitochondrion|integral to membrane|membrane raft|plasma membrane
YOL016C	YOL016C	CMK2	hom	Verified	1.11688817249515	0.132021071164019	no	669	0.137382939124868	484	NA	FT	SIGNALING|PROTEIN PHOSPHORYLATION			Calmodulin-dependent protein kinase; may play a role in stress response, many CA++/calmodulan dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to mammalian Cam Kinase II; CMK2 has a paralog, CMK1, that arose from the whole genome duplication	signal transduction|protein phosphorylation	protein kinase activity|calmodulin-dependent protein kinase activity	cytoplasm
YIR031C	YIR031C	DAL7	hom	Verified	1.11684922776999	0.132029398194913	no	670	0.13653899732714	531	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM			Malate synthase, role in allantoin degradation unknown; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation	allantoin catabolic process	malate synthase activity	cellular_component
YDL146W	YDL146W	LDB17	hom	Verified	1.11559263594575	0.132298272857399	no	671	0.108560135442131	399	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Protein involved in the regulation of endocytosis; transiently recruited to actin cortical patches in a SLA1-dependent manner after late coat component assembly; GFP-fusion protein localizes to the periphery, cytoplasm, bud, and bud neck	endocytosis	molecular_function	cellular bud|cellular bud neck|cytoplasm|actin cortical patch
YIL090W	YIL090W	ICE2	hom	Verified	1.11394149706034	0.132652142728737	no	672	0.143023741891523	500	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Integral ER membrane protein with type-III transmembrane domains; required for maintenance of ER zinc homeostasis; necessary for efficient targeting of Trm1p tRNA methyltransferase to inner nuclear membrane; mutations cause defects in cortical ER morphology in both the mother and daughter cells	endoplasmic reticulum inheritance	molecular_function	integral to endoplasmic reticulum membrane|integral to membrane|endoplasmic reticulum
YPL188W	YPL188W	POS5	hom	Verified	1.10960646138246	0.133584322869936	no	673	0.133918517997258	524	NA	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS	MITOCHONDRION		Mitochondrial NADH kinase, phosphorylates NADH; also phosphorylates NAD(+) with lower specificity; required for the response to oxidative stress	cellular response to oxidative stress|NADP biosynthetic process	NADH kinase activity	mitochondrion|mitochondrial matrix
YJL124C	YJL124C	LSM1	hom	Verified	1.10889056946524	0.133738696300229	no	674	0.166841606150431	595	NA	FF|FT	RNA PROCESSING	NUCLEUS		Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) involved in degradation of cytoplasmic mRNAs; unlike most Sm-like proteins, Lsm1p requires both its SM-domain and C-terminal domain for RNA-binding; forms cytoplasmic foci upon DNA replication stress	deadenylation-dependent decapping of nuclear-transcribed mRNA|nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	RNA binding|RNA cap binding	mRNA cap binding complex|cytoplasmic mRNA processing body|cytoplasm
YJL016W_p	YJL016W	YJL016W	hom	Uncharacterized	1.10796619455896	0.133938207917782	no	675	0.142948188598952	487	NA					Putative protein of unknown function; GFP-fusion protein localizes to the cytoplasm; conserved in closely related Saccharomyces species	biological_process	molecular_function	cytoplasm
YDR051C	YDR051C	DET1	hom	Verified	1.10730063983191	0.134081983905358	no	676	0.118930353138835	395	NA	FT		NUCLEUS		Acid phosphatase involved in the non-vesicular transport of sterols in both directions between the endoplasmic reticulum and plasma membrane; deletion confers sensitivity to nickel	intracellular sterol transport|dephosphorylation	acid phosphatase activity	nucleus|cytoplasm
YOR313C	YOR313C	SPS4	hom	Verified	1.10714305024814	0.134116042603173	no	677	0.132771682667405	486	NA	FT	CELL CYCLE			Protein whose expression is induced during sporulation; not required for sporulation; heterologous expression in E. coli induces the SOS response that senses DNA damage	ascospore formation	molecular_function	cellular_component
YNL299W	YNL299W	TRF5	hom	Verified	1.10648281116405	0.134258799913389	no	678	0.14850727220326	531	NA	FT	CELL CYCLE|RNA PROCESSING|CELL DIVISION	NUCLEUS		Non-canonical poly(A) polymerase, involved in nuclear RNA degradation as a component of the TRAMP complex; catalyzes polyadenylation of hypomodified tRNAs, and snoRNA and rRNA precursors; overlapping but non-redundant functions with Pap2p	nuclear polyadenylation-dependent CUT catabolic process|nuclear polyadenylation-dependent tRNA catabolic process|nuclear polyadenylation-dependent snoRNA catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|nuclear polyadenylation-dependent snRNA catabolic process|ncRNA polyadenylation|histone mRNA catabolic process|nuclear polyadenylation-dependent mRNA catabolic process|U4 snRNA 3'-end processing|polyadenylation-dependent snoRNA 3'-end processing|snoRNA polyadenylation	polynucleotide adenylyltransferase activity	nucleolus|TRAMP complex
YLR350W	YLR350W	ORM2	hom	Verified	1.10483113312452	0.134616383758285	no	679	0.143863621755176	568	NA	FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Evolutionarily conserved protein, similar to Orm1p; required for resistance to agents that induce unfolded protein response; Orm1p and Orm2p together control membrane biogenesis by coordinating lipid homeostasis with protein quality control; protein abundance increases in response to DNA replication stress	cellular sphingolipid homeostasis|negative regulation of sphingolipid biosynthetic process|response to unfolded protein	molecular_function	integral to membrane|endoplasmic reticulum|SPOTS complex
YMR135C	YMR135C	GID8	hom	Verified	1.1038108121929	0.13483760682998	no	680	0.140331268852413	493	NA	FT	KETONE METABOLISM|CELL CYCLE|CARBOHYDRATE METABOLISM|PROTEOLYSIS	NUCLEUS		Subunit of GID Complex, binds strongly to central component Vid30p; GID Complex is involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; recruits Rmd5p, Fyv10 and Vid28p to GID Complex; contains LisH, CTLH, and CRA domains that mediate binding to Vid30p (LisH) and Rmd5p and Vid28p (CTLH and CRA); dosage-dependent regulator of START	negative regulation of gluconeogenesis|proteasomal ubiquitin-dependent protein catabolic process|traversing start control point of mitotic cell cycle	molecular_function	nucleus|GID complex|cytoplasm
YNR050C	YNR050C	LYS9	hom	Verified	1.10319424477513	0.134971410051878	no	681	0.143443527935998	530	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS			Saccharopine dehydrogenase (NADP+, L-glutamate-forming); catalyzes the formation of saccharopine from alpha-aminoadipate 6-semialdehyde, the seventh step in lysine biosynthesis pathway; exhibits genetic and physical interactions with TRM112	lysine biosynthetic process via aminoadipic acid	saccharopine dehydrogenase (NADP+, L-glutamate-forming) activity	cytoplasm
YMR067C	YMR067C	UBX4	hom	Verified	1.10318964875929	0.134972407789478	no	682	0.162416155867741	565	NA	FT	PROTEOLYSIS	NUCLEUS		UBX domain-containing protein that interacts with Cdc48p; involved in degradation of polyubiquitinated proteins via the ERAD (ER-associated degradation) pathway; modulates the Cdc48p-Nplp-Ufd1p AAA ATPase complex during its role in delivery of misfolded proteins to the proteasome; protein abundance increases in response to DNA replication stress	ER-associated protein catabolic process|sporulation resulting in formation of a cellular spore	protein complex binding	nucleus|cytoplasm|extrinsic to membrane
YCL002C_p	YCL002C	YCL002C	hom	Uncharacterized	1.10264020614618	0.135091721367243	no	683	0.134890934125469	487	NA					Putative protein of unknown function; YCL002C is not an essential gene	biological_process	molecular_function	integral to membrane
YER017C	YER017C	AFG3	hom	Verified	1.10225472341955	0.135175473584587	no	684	0.174674094670917	592	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Component, with Yta12p, of the mitochondrial inner membrane m-AAA protease; mediates degradation of misfolded or unassembled proteins and is also required for correct assembly of mitochondrial enzyme complexes; involved in cytoplasmic mRNA translation and aging	proteolysis|signal peptide processing|protein complex assembly|protein import into mitochondrial intermembrane space	metallopeptidase activity|protein binding|ATPase activity	mitochondrion|mitochondrial inner boundary membrane|mitochondrial inner membrane|m-AAA complex
YDL051W	YDL051W	LHP1	hom	Verified	1.10155366756985	0.135327880283512	no	685	0.136813953993519	481	NA	FT	RNA PROCESSING	NUCLEUS		RNA binding protein required for maturation of tRNA and U6 snRNA precursors; acts as a molecular chaperone for RNAs transcribed by polymerase III; homologous to human La (SS-B) autoantigen	tRNA processing	RNA binding|tRNA binding	nucleoplasm|nucleolus|nucleus
YIR025W	YIR025W	MND2	hom	Verified	1.10084315926304	0.135482462041978	no	686	0.148552844465897	541	NA	FT	CELL CYCLE|CELL DIVISION|PROTEOLYSIS|CHROMOSOME SEGREGATION	NUCLEUS	UBIQUITIN LIGASE COMPLEX	Subunit of the anaphase-promoting complex (APC); necessary for maintaining sister chromatid cohesion in prophase I of meiosis by inhibiting premature ubiquitination and subsequent degradation of substrates by the APC(Ama1) ubiquitin ligase	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|reciprocal meiotic recombination|regulation of mitotic metaphase/anaphase transition|protein ubiquitination|mitotic sister chromatid segregation	molecular_function	nucleus|anaphase-promoting complex
YCR011C	YCR011C	ADP1	hom	Verified	1.10074871582408	0.135503018738334	no	687	0.117642462571711	449	NA	FT	NUCLEOTIDE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Putative ATP-dependent permease of the ABC transporter family of proteins	transport|transmembrane transport	ATPase activity, coupled to transmembrane movement of substances	integral to membrane|endoplasmic reticulum|cytoplasm
YDL116W	YDL116W	NUP84	hom	Verified	1.09884863028428	0.135917048195051	no	688	0.135008399857745	542	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|RIBOSOME BIOGENESIS|RESPONSE TO DNA DAMAGE|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport and NPC biogenesis; also plays roles in several processes that may require localization of genes or chromosomes at the nuclear periphery, including double-strand break repair, transcription and chromatin silencing; homologous to human NUP107	double-strand break repair|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|maintenance of chromatin silencing at telomere|nuclear pore distribution|telomere tethering at nuclear periphery|response to DNA damage stimulus|mRNA export from nucleus in response to heat stress|mRNA export from nucleus|positive regulation of transcription, DNA-dependent|protein import into nucleus|positive regulation of transcription from RNA polymerase II promoter|chromatin silencing at silent mating-type cassette	structural constituent of nuclear pore	integral to membrane|nuclear pore outer ring|nuclear pore
YHR198C	YHR198C	AIM18	hom	Verified	1.09750650807599	0.136210018680948	no	689	0.137745193351014	509	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss	biological_process	molecular_function	mitochondrion
YMR109W	YMR109W	MYO5	hom	Verified	1.09701142390931	0.136318199127193	no	690	0.1193137908067	442	NA	FT	VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS|CELL DIVISION	SITE OF POLARIZED GROWTH|CYTOSKELETON		One of two type I myosins; contains proline-rich tail homology 2 (TH2) and SH3 domains; MYO5 deletion has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization	bipolar cellular bud site selection|endocytosis|exocytosis|fungal-type cell wall organization|response to salt stress|receptor-mediated endocytosis|actin cortical patch localization|response to osmotic stress	microfilament motor activity	mating projection tip|actin cortical patch
YOR211C	YOR211C	MGM1	hom	Verified	1.0969560846748	0.136330294910805	no	691	0.127256192023971	474	NA	FT	MEMBRANE ORGANIZATION|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial GTPase, present in complex with Ugo1p and Fzo1p; required for mt morphology and genome maintenance; exists as long and short form with different distributions; homolog of human OPA1 involved in autosomal dominant optic atrophy	mitochondrion organization|mitochondrial genome maintenance|mitochondrial fusion	GTPase activity	intrinsic to mitochondrial inner membrane|extrinsic to mitochondrial inner membrane|mitochondrion|mitochondrial inner boundary membrane|mitochondrial crista|mitochondrial intermembrane space
YBL099W	YBL099W	ATP1	hom	Verified	1.09688914700518	0.136344926805826	no	692	0.14955684865843	588	NA	FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS	MITOCHONDRION		Alpha subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated	ATP synthesis coupled proton transport	hydrogen ion transporting ATP synthase activity, rotational mechanism|ATPase activity|proton-transporting ATPase activity, rotational mechanism	mitochondrial nucleoid|proton-transporting ATP synthase complex, catalytic core F(1)|mitochondrion|integral to membrane|mitochondrial proton-transporting ATP synthase, catalytic core
YMR216C	YMR216C	SKY1	hom	Verified	1.09677722752721	0.136369393667385	no	693	0.211882166448088	753	NA	FF|FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|ION HOMEOSTASIS|PROTEIN PHOSPHORYLATION|ION HOMEOSTASIS			SR protein kinase (SRPK) involved in regulating proteins involved in mRNA metabolism and cation homeostasis; similar to human SRPK1	cellular cation homeostasis|cellular ion homeostasis|response to drug|protein phosphorylation|positive regulation of protein import into nucleus|regulation of cell size|mRNA splice site selection	protein serine/threonine kinase activity|protein kinase activity	cytoplasm
YIR024C	YIR024C	YIR024C	hom	Verified	1.09617260160835	0.136501623663555	no	694	0.149716352627685	510	NA	FT		MITOCHONDRION		Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; interacts with Arh1p, a mitochondrial oxidoreductase; deletion mutant has a respiratory growth defect	biological_process	molecular_function	mitochondrion
YKL149C	YKL149C	DBR1	hom	Verified	1.09527287091014	0.136698554544794	no	695	0.128799493581743	471	NA	FT	RNA PROCESSING	NUCLEUS		RNA lariat debranching enzyme, involved in intron turnover; required for efficient Ty1 transposition	snoRNA metabolic process|pseudohyphal growth|RNA catabolic process|transposition, RNA-mediated	RNA lariat debranching enzyme activity	nucleus
YNL063W	YNL063W	MTQ1	hom	Verified	1.0936070148607	0.137063685660238	no	696	0.14338970435704	506	NA	FT	TRANSLATION	MITOCHONDRION		S-adenosylmethionine-dependent methyltransferase; methylates translational release factor Mrf1p; similar to E.coli PrmC; is not an essential gene	translational readthrough	S-adenosylmethionine-dependent methyltransferase activity	mitochondrion
YLR014C	YLR014C	PPR1	hom	Verified	1.09249739816076	0.137307266732564	no	697	0.1722535578428	569	NA	FT	TRANSCRIPTION FROM RNA POL II|NUCLEOTIDE METABOLISM	NUCLEUS		Zinc finger transcription factor containing a Zn(2)-Cys(6) binuclear cluster domain, positively regulates transcription of URA1, URA3, URA4, and URA10, which are involved in de novo pyrimidine biosynthesis, in response to pyrimidine starvation; activity may be modulated by interaction with Tup1p	positive regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding RNA polymerase II transcription factor activity|sequence-specific DNA binding|zinc ion binding	nucleus
YBR201W	YBR201W	DER1	hom	Verified	1.09098991869326	0.137638659302789	no	698	0.139111241713364	515	NA	FT	PROTEIN LOCALIZATION|PROTEOLYSIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	UBIQUITIN LIGASE COMPLEX	Endoplasmic reticulum membrane protein, required for ER-associated protein degradation of misfolded or unassembled proteins; N- and C- termini protrude into the cytoplasm, has similarity to Dfm1p	ER-associated protein catabolic process	molecular_function	integral to membrane|Hrd1p ubiquitin ligase ERAD-L complex|endoplasmic reticulum membrane
YJR040W	YJR040W	GEF1	hom	Verified	1.0901479530248	0.137823987892482	no	699	0.144415197960455	580	NA	FF|FT	ION HOMEOSTASIS|ION HOMEOSTASIS	ENDOPLASMIC RETICULUM|GOLGI APPARATUS|PLASMA MEMBRANE		Voltage-gated chloride channel localized to the golgi, the endosomal system, and plasma membrane, and involved in cation homeostasis; highly homologous to vertebrate voltage-gated chloride channels; modulates TBSV model (+) RNA virus replication by regulating copper metabolism	cellular copper ion homeostasis|cellular iron ion homeostasis	voltage-gated chloride channel activity	endosome|integral to membrane|endoplasmic reticulum|Golgi apparatus|plasma membrane|fungal-type vacuole|Golgi medial cisterna
YBR054W	YBR054W	YRO2	hom	Verified	1.08875533520418	0.13813089638051	no	700	0.116832373797696	463	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Protein of unknown function with similarity to archaeal rhodopsins; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; transcriptionally regulated by Haa1p; YRO2 has a paralog, MRH1, that arose from the whole genome duplication	biological_process	molecular_function	mitochondrion|integral to membrane|cellular bud
YDL085C-A_p	YDL085C-A	YDL085C-A	hom	Uncharacterized	1.08854725260085	0.138176794115971	no	701	0.141970974726641	499	NA	FT		NUCLEUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus	biological_process	molecular_function	nucleus|cytoplasm
YMR173W	YMR173W	DDR48	hom	Verified	1.08815089638351	0.138264248992164	no	702	0.116899142964118	402	NA	FT	RESPONSE TO DNA DAMAGE			DNA damage-responsive protein; expression is increased in response to heat-shock stress or treatments that produce DNA lesions; contains multiple repeats of the amino acid sequence NNNDSYGS; protein abundance increases in response to DNA replication stress	DNA repair	ATPase activity|GTPase activity	cytoplasm
YDL123W	YDL123W	SNA4	hom	Verified	1.08677721826456	0.138567639148784	no	703	0.153625570506431	441	NA					Protein of unknown function, localized to the vacuolar outer membrane; predicted to be palmitoylated	biological_process	molecular_function	fungal-type vacuole lumen|fungal-type vacuole membrane
YPL119C	YPL119C	DBP1	hom	Verified	1.08585698419573	0.138771135303969	no	704	0.119435098985544	416	NA	FT	TRANSLATION			Putative ATP-dependent RNA helicase of the DEAD-box protein family; mutants show reduced stability of the 40S ribosomal subunit scanning through 5' untranslated regions of mRNAs; protein abundance increases in response to DNA replication stress	translational initiation	RNA helicase activity	cytoplasm
YNL315C	YNL315C	ATP11	hom	Verified	1.08584738792708	0.138773258448634	no	705	0.140604080108567	531	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Molecular chaperone, required for the assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase	mitochondrion organization|mitochondrial proton-transporting ATP synthase complex assembly	unfolded protein binding	mitochondrion|mitochondrial matrix
YKR043C	YKR043C	SHB17	hom	Verified	1.08461674109293	0.139045718595303	no	706	0.179618059798235	614	NA	FT	CARBOHYDRATE METABOLISM	NUCLEUS		Sedoheptulose bisphosphatase involved in riboneogenesis; dephosphorylates sedoheptulose 1,7-bisphosphate, which is converted via the nonoxidative pentose phosphate pathway to ribose-5-phosphate; facilitates the conversion of glycolytic intermediates to pentose phosphate units; also has fructose 1,6-bisphosphatase activity but this is probably not biologically relevant, since deletion does not affect FBP levels; GFP-fusion protein localizes to the cytoplasm and nucleus	ribose phosphate biosynthetic process	sedoheptulose-bisphosphatase activity	nucleus|cytoplasm
YDR485C	YDR485C	VPS72	hom	Verified	1.08276032063231	0.139457411010241	no	707	0.196632767185577	712	NA	FF|FT	CHROMATIN ORGANIZATION	NUCLEUS|CHROMOSOME		Htz1p-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting	chromatin remodeling|histone exchange	histone binding	Swr1 complex|nucleus|cytoplasm
YGR232W	YGR232W	NAS6	hom	Verified	1.08028911502591	0.140006727666525	no	708	0.144949303622697	529	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS	NUCLEUS		Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); ortholog of human oncoprotein gankyrin, which interacts with the Rb tumor suppressor and CDK4/6	proteolysis|proteasome regulatory particle assembly	molecular_function	cytosol|nucleus|proteasome regulatory particle
YBR220C_p	YBR220C	YBR220C	hom	Uncharacterized	1.07985651325675	0.140103040389604	no	709	0.136234771086702	465	NA					Putative protein of unknown function; YBR220C is not an essential gene	biological_process	molecular_function	integral to membrane
YBR203W	YBR203W	COS111	hom	Verified	1.07967095719075	0.140144365639223	no	710	0.177567051061343	598	NA	FT	SIGNALING	MITOCHONDRION		Protein required for resistance to the antifungal drug ciclopirox olamine; not related to the subtelomerically-encoded COS family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	signal transduction	molecular_function	mitochondrion
YIL138C	YIL138C	TPM2	hom	Verified	1.07910772759788	0.140269853388736	no	711	0.158744090102795	582	NA	FT	VESICLE-MEDIATED TRANSPORT|CELL DIVISION|MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION|RNA LOCALIZATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Minor isoform of tropomyosin; binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; appears to have distinct and also overlapping functions with Tpm1p; TPM2 has a paralog, TPM1, that arose from the whole genome duplication	vacuole inheritance|exocytosis|intracellular mRNA localization|budding cell apical bud growth|budding cell isotropic bud growth|mitochondrion inheritance|actin polymerization or depolymerization|vesicle-mediated transport|actin filament organization|establishment of cell polarity|actin filament bundle assembly	actin lateral binding	cellular bud neck contractile ring|actin filament bundle
YLR146C	YLR146C	SPE4	hom	Verified	1.07897486183746	0.14029946704773	no	712	0.127109157975433	488	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM			Spermine synthase, required for the biosynthesis of spermine and also involved in biosynthesis of pantothenic acid	pantothenate biosynthetic process|spermine biosynthetic process	spermine synthase activity	cytoplasm
YIL110W	YIL110W	HPM1	hom	Verified	1.07796291398523	0.140525153401854	no	713	0.145922613434536	492	NA	FT		NUCLEUS		AdoMet-dependent methyltransferase involved in a novel 3-methylhistidine modification of ribosomal protein Rpl3p; seven beta-strand MTase family member; null mutant exhibits a weak vacuolar protein sorting defect and caspofungin resistance	peptidyl-histidine methylation, to form tele-methylhistidine	S-adenosylmethionine-dependent methyltransferase activity|protein-histidine N-methyltransferase activity	nucleus|cytoplasm
YMR300C	YMR300C	ADE4	hom	Verified	1.07721683710093	0.140691702501307	no	714	0.150420504062242	553	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEOTIDE METABOLISM			Phosphoribosylpyrophosphate amidotransferase (PRPPAT; amidophosphoribosyltransferase), catalyzes first step of the 'de novo' purine nucleotide biosynthetic pathway	'de novo' IMP biosynthetic process	amidophosphoribosyltransferase activity	cytoplasm
YPL084W	YPL084W	BRO1	hom	Verified	1.07417979921452	0.141371052210941	no	715	0.147825674355483	559	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEOLYSIS|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS			Cytoplasmic class E vacuolar protein sorting (VPS) factor that coordinates deubiquitination in the multivesicular body (MVB) pathway by recruiting Doa4p to endosomes	protein deubiquitination|vacuolar transport|protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|response to nutrient|ubiquitin-dependent protein catabolic process	ubiquitin-specific protease activity	endosome|cytoplasm
YGR260W	YGR260W	TNA1	hom	Verified	1.07342651491423	0.141539896609753	no	716	0.158785004016929	534	NA	FT		MITOCHONDRION|PLASMA MEMBRANE		High affinity nicotinic acid plasma membrane permease, responsible for uptake of low levels of nicotinic acid; expression of the gene increases in the absence of extracellular nicotinic acid or para-aminobenzoate (PABA)	nicotinamide mononucleotide transport	nicotinamide mononucleotide transmembrane transporter activity	mitochondrion|integral to membrane|integral to plasma membrane
YIR021W-A_p	YIR021W-A	YIR021W-A	hom	Uncharacterized	1.07259361594469	0.141726745183109	no	717	0.144112649403984	495	NA					Putative protein of unknown function; identified by expression profiling and mass spectrometry	biological_process	molecular_function	cellular_component
YKL080W	YKL080W	VMA5	hom	Verified	1.07219424792723	0.141816396728367	no	718	0.19943338211587	664	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Subunit C of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane	vacuolar acidification	proton-transporting ATPase activity, rotational mechanism	fungal-type vacuole membrane|vacuolar proton-transporting V-type ATPase, V1 domain|integral to membrane
YOR064C	YOR064C	YNG1	hom	Verified	1.07173779228465	0.141918910528071	no	719	0.147917371127796	531	NA	FT	CHROMATIN ORGANIZATION	NUCLEUS	HISTONE ACETYLTRANSFERASE	Subunit of the NuA3 histone acetyltransferase complex that acetylates histone H3; contains PHD finger domain that interacts with methylated histone H3, has similarity to the human tumor suppressor ING1	histone acetylation|chromatin modification	histone acetyltransferase activity|methylated histone residue binding	NuA3 histone acetyltransferase complex
YER121W_p	YER121W	YER121W	hom	Uncharacterized	1.07107275128042	0.142068359579342	no	720	0.163334487847717	538	NA					Putative protein of unknown function; may be involved in phosphatase regulation and/or generation of precursor metabolites and energy	biological_process	molecular_function	cellular_component
YEL042W	YEL042W	GDA1	hom	Verified	1.0704406919912	0.142210495628641	no	721	0.136068287119822	487	NA	FT	CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Guanosine diphosphatase located in the Golgi, involved in the transport of GDP-mannose into the Golgi lumen by converting GDP to GMP after mannose is transferred its substrate	protein glycosylation	guanosine-diphosphatase activity|uridine-diphosphatase activity	Golgi apparatus
YNL252C	YNL252C	MRPL17	hom	Verified	1.07027798647329	0.142247100042768	no	722	0.14469834142756	529	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YGR159C	YGR159C	NSR1	hom	Verified	1.06032060635935	0.144499383845092	no	723	0.160375077757726	500	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS|MITOCHONDRION		Nucleolar protein that binds nuclear localization sequences, required for pre-rRNA processing and ribosome biogenesis	ribosomal small subunit assembly|rRNA processing	single-stranded DNA binding|RNA binding	mitochondrion|nucleolus|nucleus
YLR389C	YLR389C	STE23	hom	Verified	1.05607025912572	0.145468058430801	no	724	0.122872275084847	469	NA	FT	PROTEOLYSIS			Metalloprotease involved, with homolog Axl1p, in N-terminal processing of pro-a-factor to the mature form; expressed in both haploids and diploids; member of the insulin-degrading enzyme family	peptide pheromone maturation	metallopeptidase activity|metalloendopeptidase activity	extrinsic to membrane
YJR124C_p	YJR124C	YJR124C	hom	Uncharacterized	1.05545395733958	0.145608878280272	no	725	0.117812588980938	456	NA					Putative protein of unknown function; expression induced under calcium shortage	biological_process	molecular_function	integral to membrane
YDR465C	YDR465C	RMT2	hom	Verified	1.0548992537789	0.145735701795983	no	726	0.171070905738508	510	NA	FT		NUCLEUS		Arginine N5 methyltransferase; methylates ribosomal protein Rpl12 (L12) on Arg67; relative distribution to the nucleus increases upon DNA replication stress	peptidyl-arginine methylation	protein-arginine N5-methyltransferase activity	nucleus|cytoplasm
YPL041C_p	YPL041C	YPL041C	hom	Uncharacterized	1.05467806471785	0.145786293606965	no	727	0.140642134000984	440	NA					Protein of unknown function involved in maintenance of proper telomere length	biological_process	molecular_function	cellular_component
YMR259C	YMR259C	TRM732	hom	Verified	1.05249365453715	0.146286560147658	no	728	0.157354576406382	572	NA					Interacts with Trm7p for 2'-O-methylation of C32 of substrate tRNAs; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; non-essential gene	biological_process	molecular_function	cytoplasm
YKR098C	YKR098C	UBP11	hom	Verified	1.05199059989021	0.146401931205846	no	729	0.147119816538093	544	NA	FT	PROTEOLYSIS			Ubiquitin-specific protease that cleaves ubiquitin from ubiquitinated proteins	biological_process	ubiquitin-specific protease activity	cellular_component
YHL014C	YHL014C	YLF2	hom	Verified	1.05175765881605	0.14645537483277	no	730	0.144908401879389	489	NA	FT		MITOCHONDRION		Protein of unknown function, has weak similarity to E. coli GTP-binding protein gtp1; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	GTP binding	mitochondrion
YKL026C	YKL026C	GPX1	hom	Verified	1.05121219040243	0.146580572784033	no	731	0.151148745619438	531	NA	FT	OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS			Phospholipid hydroperoxide glutathione peroxidase induced by glucose starvation that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress	cellular response to oxidative stress|peroxisome organization	phospholipid-hydroperoxide glutathione peroxidase activity|glutathione peroxidase activity	extrinsic to mitochondrial outer membrane|peroxisomal matrix
YIR020W-A_d	YIR020W-A	YIR020W-A	hom	Dubious	1.04903310244718	0.14708144168892	no	732	0.159421049149492	536	NA					Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data	Unknown	Unknown	Unknown
YOR309C_d	YOR309C	YOR309C	hom	Dubious	1.048664546016	0.147166268645523	no	733	0.172457218005108	585	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NOP58	Unknown	Unknown	Unknown
YOL104C	YOL104C	NDJ1	hom	Verified	1.04676487145459	0.147604017910929	no	734	0.124150853492786	459	NA	FT	CELL CYCLE	NUCLEUS|CHROMOSOME		Meiosis-specific telomere protein, required for bouquet formation, effective homolog pairing, ordered cross-over distribution, sister chromatid cohesion at meiotic telomeres, chromosomal segregation and telomere-led rapid prophase movement	meiotic telomere clustering|synapsis|attachment of telomeric heterochromatin to nuclear envelope|regulation of reciprocal meiotic recombination|reciprocal meiotic recombination	telomeric DNA binding	nuclear chromosome, telomeric region
YOR375C	YOR375C	GDH1	hom	Verified	1.04621224267318	0.147731525873314	no	735	0.13995160828221	485	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS	NUCLEUS		NADP(+)-dependent glutamate dehydrogenase; synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh3p; expression regulated by nitrogen and carbon sources; GDH1 has a paralog, GDH3, that arose from the whole genome duplication	glutamate biosynthetic process|ammonia assimilation cycle	glutamate dehydrogenase (NADP+) activity	nucleus|cytoplasm
YOR286W	YOR286W	RDL2	hom	Verified	1.04602379126352	0.147775024101861	no	736	0.136381403660903	485	NA	FT		MITOCHONDRION		Protein with rhodanese activity; contains a rhodanese-like domain similar to Rdl1p, Uba4p, Tum1p, and Ych1p; overexpression causes a cell cycle delay; null mutant displays elevated frequency of mitochondrial genome loss	biological_process	thiosulfate sulfurtransferase activity	mitochondrion
YBR086C	YBR086C	IST2	hom	Verified	1.04590905019732	0.147801512758279	no	737	0.160981033015527	545	NA	FT		PLASMA MEMBRANE		Cortical ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; localizes to the mother cell in small-budded cells and to the bud in medium- and large-budded cells; mRNA is transported to the bud tip by an actomyosin-driven process	response to osmotic stress	lipid binding	integral to membrane|cellular bud membrane|plasma membrane
YMR004W	YMR004W	MVP1	hom	Verified	1.04298059334551	0.148478640469463	no	738	0.165055501374168	566	NA	FT	PROTEIN LOCALIZATION|VACUOLAR TRANSPORT	NUCLEUS		Protein required for sorting proteins to the vacuole; Mvp1p and Vps1p act in concert to promote membrane traffic to the vacuole; participates in transcription initiation and/or early elongation of specific genes; interacts with foot domain of RNA polymerase II; deletion results in abnormal CTD-Ser5 phosphorylation of RNA polymerase II at specific promoter regions; protein abundance increases in response to DNA replication stress	protein targeting to vacuole	phosphatidylinositol-3-phosphate binding	nucleus|cytoplasm
YPL254W	YPL254W	HFI1	hom	Verified	1.04152545121225	0.148815873661012	no	739	0.166498442430236	570	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION	NUCLEUS	HISTONE ACETYLTRANSFERASE	Adaptor protein required for structural integrity of the SAGA complex, a histone acetyltransferase-coactivator complex that is involved in global regulation of gene expression through acetylation and transcription functions	histone acetylation|chromatin modification|transcription from RNA polymerase II promoter	transcription coactivator activity|transcription cofactor activity	SLIK (SAGA-like) complex|Ada2/Gcn5/Ada3 transcription activator complex|SAGA complex
YPL002C	YPL002C	SNF8	hom	Verified	1.04098078002534	0.148942234261518	no	740	0.172110776055122	629	NA	FF|FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|PROTEOLYSIS|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS			Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; appears to be functionally related to SNF7; involved in glucose derepression	negative regulation of transcription from RNA polymerase II promoter by glucose|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|protein targeting to vacuole	molecular_function	ESCRT II complex
YBR162C	YBR162C	TOS1	hom	Verified	1.04078453918253	0.14898777857643	no	741	0.137580951497523	492	NA					Covalently-bound cell wall protein of unknown function; identified as a cell cycle regulated SBF target gene; deletion mutants are highly resistant to treatment with beta-1,3-glucanase; has sequence similarity to YJL171C	biological_process	molecular_function	fungal-type cell wall|fungal-type vacuole
YKL069W	YKL069W	YKL069W	hom	Verified	1.04044123936348	0.14906747526593	no	742	0.139283140706058	517	NA	FT	OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		Methionine-R-sulfoxide reductase; reduces the R enantiomer of free Met-SO, in contrast to Ycl033Cp which reduces Met-R-SO in a peptide linkage; has a role in protection against oxidative stress; relative distribution to the nucleus increases upon DNA replication stress	cellular response to oxidative stress	methionine-R-sulfoxide reductase activity	nucleus|cytoplasm
YIL039W	YIL039W	TED1	hom	Verified	1.03712197765802	0.149839506916482	no	743	0.186944550375515	674	NA	FT	VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Conserved phosphoesterase domain-containing protein that acts together with Emp24p/Erv25p in cargo exit from the ER; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)	ER to Golgi vesicle-mediated transport	molecular_function	endoplasmic reticulum
YDR072C	YDR072C	IPT1	hom	Verified	1.03554180211954	0.150207977470832	no	744	0.149371483113773	566	NA	FT	LIPID METABOLISM			Inositolphosphotransferase, involved in synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C), the most abundant sphingolipid; can mutate to resistance to the antifungals syringomycin E and DmAMP1 and to K. lactis zymocin	mannosyl diphosphorylinositol ceramide metabolic process|sphingolipid biosynthetic process	transferase activity, transferring phosphorus-containing groups	integral to membrane
YER128W	YER128W	VFA1	hom	Verified	1.0348558024586	0.150368128983533	no	745	0.15425340610756	571	NA	FT	VACUOLAR TRANSPORT			Protein that interacts with Vps4p and has a role in vacuolar sorting; localizes to endosomes in a Vps4-dependent manner; overexpression causes canavanine sensitivity and confers a partial class D vacuole morphology	vacuolar transport	molecular_function	endosome|cytoplasm
YCR073W-A	YCR073W-A	SOL2	hom	Verified	1.03457651873258	0.150433362337676	no	746	0.16208125270025	601	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|RNA LOCALIZATION|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS			Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol3p and Sol4p; SOL2 has a paralog, SOL1, that arose from the whole genome duplication	tRNA export from nucleus	molecular_function|6-phosphogluconolactonase activity	cytosol|cytoplasm
YHR113W	YHR113W	APE4	hom	Verified	1.03325670437038	0.150741891405802	no	747	0.13870607120277	537	NA	FT	PROTEOLYSIS			Cytoplasmic aspartyl aminopeptidase that may also function in the vacuole; CVT pathway cargo protein; cleaves unblocked N-terminal acidic amino acids from peptide substrates; forms a 12-subunit homo-oligomer; M18 metalloprotease family	proteolysis	aminopeptidase activity	fungal-type vacuole lumen|ribosome|cytoplasm
YPL004C	YPL004C	LSP1	hom	Verified	1.03096679921741	0.151278194687293	no	748	0.138246382770109	490	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|PROTEIN PHOSPHORYLATION	MITOCHONDRION		Primary component of eisosomes, which are large immobile patch structures at the cell cortex associated with endocytosis, along with Pil1p and Sur7p; null mutants show activation of Pkc1p/Ypk1p stress resistance pathways; member of the BAR domain family	negative regulation of protein kinase activity|endocytosis|response to heat	lipid binding	mitochondrial outer membrane|eisosome|mitochondrion|plasma membrane|cytoplasm
YDL013W	YDL013W	SLX5	hom	Verified	1.03010145374942	0.151481191441129	no	749	0.199240226715537	695	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS	UBIQUITIN LIGASE COMPLEX	Subunit of the Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex, stimulated by SUMO-modified substrates; contains a RING domain and two SIMs (SUMO-interacting motifs); forms SUMO-dependent nuclear foci, including DNA repair centers	protein sumoylation|telomere maintenance|response to DNA damage stimulus|protein ubiquitination	SUMO binding|ubiquitin-protein ligase activity	ubiquitin ligase complex|nucleus
YLR257W	YLR257W	YLR257W	hom	Verified	1.02997180570881	0.151511620472636	no	750	0.147856828885885	506	NA					Protein of unknown function; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	cytoplasm
YER044C-A	YER044C-A	MEI4	hom	Verified	1.02984016802478	0.151542520640819	no	751	0.139015693287613	501	NA	FT	CELL CYCLE	NUCLEUS|CHROMOSOME		Meiosis-specific protein involved in double-strand break formation during meiotic recombination; required for chromosome synapsis and production of viable spores	meiotic DNA double-strand break formation	molecular_function	condensed nuclear chromosome
YMR206W_p	YMR206W	YMR206W	hom	Uncharacterized	1.02951914561436	0.151617893880778	no	752	0.135311624883269	483	NA					Putative protein of unknown function; not an essential gene; YMR206W has a paralog, YNR014W, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YEL020C_p	YEL020C	YEL020C	hom	Uncharacterized	1.02713019642858	0.15217958076154	no	753	0.160504979605347	533	NA					Protein of unknown function with low sequence identity to Pdc1p; mRNA identified as translated by ribosome profiling data	biological_process	molecular_function	cytoplasm
YOR171C	YOR171C	LCB4	hom	Verified	1.02709598745658	0.152187633955388	no	754	0.129401180633617	468	NA	FT	LIPID METABOLISM|SIGNALING|PROTEIN PHOSPHORYLATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS|PLASMA MEMBRANE		Sphingoid long-chain base kinase, responsible for synthesis of long-chain base phosphates, which function as signaling molecules, regulates synthesis of ceramide from exogenous long-chain bases, localizes to the Golgi and late endosomes	calcium-mediated signaling|sphingolipid metabolic process	D-erythro-sphingosine kinase activity	Golgi apparatus|endoplasmic reticulum|plasma membrane|cortical endoplasmic reticulum
YDL118W_d	YDL118W	YDL118W	hom	Dubious	1.02340822211239	0.153057436749393	no	755	0.190465081151458	692	NA	FF|FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Dubious open reading frame, unlikely to encode a protein; overlaps almost completely with YDL119C; mutations that would affect both YDL118W and YDL119C confer defective telomere maintenance and are synthetically sick or lethal with alpha-synuclein	biological_process	molecular_function	cellular_component
YIL072W	YIL072W	HOP1	hom	Verified	1.02308426813674	0.153134002241699	no	756	0.185982422588123	618	NA	FT	CELL CYCLE	NUCLEUS|CHROMOSOME		Meiosis-specific protein required for chromosome synapsis; displays Red1p dependent localization to the unsynapsed axial-lateral elements of the synaptonemal complex; required for chiasma formation; in vitro, displays the ability to promote intra- and intermolecular synapsis between double-stranded DNA molecules and to fold DNA into rigid protein?DNA filaments	synaptonemal complex assembly|meiotic recombination checkpoint|synapsis	four-way junction DNA binding	condensed nuclear chromosome|lateral element
YFL016C	YFL016C	MDJ1	hom	Verified	1.02285276869784	0.153188731947071	no	757	0.215806492568789	686	NA	FT	PROTEOLYSIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Co-chaperone that stimulates the ATPase activity of the HSP70 protein Ssc1p; involved in protein folding/refolding in the mitochodrial matrix; required for proteolysis of misfolded proteins; member of the HSP40 (DnaJ) family of chaperones	protein refolding|response to heat|misfolded or incompletely synthesized protein catabolic process|mitochondrial genome maintenance|'de novo' protein folding	unfolded protein binding|ATPase activator activity	extrinsic to mitochondrial inner membrane|mitochondrion|mitochondrial matrix
YBL067C	YBL067C	UBP13	hom	Verified	1.02219835311103	0.153343515051354	no	758	0.165854865006419	595	NA	FT	PROTEOLYSIS			Putative ubiquitin-specific protease that cleaves Ub-protein fusions; UBP13 has a paralog, UBP9, that arose from the whole genome duplication	biological_process	ubiquitin-specific protease activity	cellular_component
YGR155W	YGR155W	CYS4	hom	Verified	1.02206842759895	0.15337425750134	no	759	0.157459082087713	593	NA	FT	KETONE METABOLISM|CELL CYCLE|AMINO ACID METABOLISM	MITOCHONDRION		Cystathionine beta-synthase, catalyzes synthesis of cystathionine from serine and homocysteine, the first committed step in cysteine biosynthesis; responsible for hydrogen sulfide generation; advances passage through START by promoting cell growth which requires catalytic activity, and reducing critical cell size independent of catalytic activity; mutations in human ortholog cause homocystinuria	cysteine biosynthetic process from serine|hydrogen sulfide biosynthetic process|cysteine biosynthetic process via cystathionine|transsulfuration|traversing start control point of mitotic cell cycle	cystathionine beta-synthase activity	mitochondrion|cytoplasm
YGR226C_d	YGR226C	YGR226C	hom	Dubious	1.02192769829797	0.153407560906219	no	760	0.158243811800271	532	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; overlaps significantly with a verified ORF, AMA1/YGR225W	Unknown	Unknown	Unknown
YHR114W	YHR114W	BZZ1	hom	Verified	1.02070391578274	0.153697369372673	no	761	0.127661671313275	477	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		SH3 domain protein implicated in the regulation of actin polymerization, able to recruit actin polymerization machinery through its SH3 domains, colocalizes with cortical actin patches and Las17p, interacts with type I myosins	response to salt stress|actin filament organization|endocytosis	molecular_function	mating projection tip|cytoplasm|actin cortical patch
YDR500C	YDR500C	RPL37B	hom	Verified	1.01936971889772	0.154013738204093	no	762	0.138061840943674	493	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L37B; protein abundance increases in response to DNA replication stress; homologous to mammalian ribosomal protein L37, no bacterial homolog; RPL37B has a paralog, RPL37A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YBR242W_p	YBR242W	YBR242W	hom	Uncharacterized	1.01827177306773	0.154274409418467	no	763	0.196331807524637	649	NA	FT		NUCLEUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YBR242W is not an essential gene	biological_process	molecular_function	nucleus|cytoplasm
YIL139C	YIL139C	REV7	hom	Verified	1.01785864620029	0.15437256833989	no	764	0.141653227172463	484	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS|MITOCHONDRION|CHROMOSOME		Accessory subunit of DNA polymerase zeta, involved in translesion synthesis during post-replication repair; required for mutagenesis induced by DNA damage; involved in double-strand break repair	error-prone translesion synthesis|error-free translesion synthesis	DNA-directed DNA polymerase activity	nuclear chromatin|mitochondrion|zeta DNA polymerase complex
YLR324W	YLR324W	PEX30	hom	Verified	1.01730110186826	0.1545051062988	no	765	0.187549486264164	653	NA	FF|FT	PEROXISOME ORGANIZATION			Peroxisomal integral membrane protein, involved in negative regulation of peroxisome number; partially functionally redundant with Pex31p; genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p	peroxisome organization	molecular_function	integral to membrane|peroxisome|integral to peroxisomal membrane
YER151C	YER151C	UBP3	hom	Verified	1.01617990084223	0.154771862884736	no	766	0.1870518335763	673	NA	FT	VESICLE-MEDIATED TRANSPORT|PROTEOLYSIS			Ubiquitin-specific protease involved in transport and osmotic response; interacts with Bre5p to co-regulate anterograde and retrograde transport between the ER and Golgi; involved in transcription elongation in response to osmostress through phosphorylation at Ser695 by Hog1p; inhibitor of gene silencing; cleaves ubiquitin fusions but not polyubiquitin; also has mRNA binding activity; protein abundance increases in response to DNA replication stress	protein deubiquitination|ribophagy|regulation of ER to Golgi vesicle-mediated transport|regulation of response to osmotic stress	ubiquitin-specific protease activity|mRNA binding	cytoplasm
YIL016W	YIL016W	SNL1	hom	Verified	1.0156761941285	0.154891803980041	no	767	0.145274327875857	590	NA	FT		ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|MITOCHONDRION		Ribosome-associated protein proposed to act in protein synthesis and nuclear pore complex biogenesis and maintenance as well as protein folding; has similarity to the mammalian BAG-1 protein	protein folding|nuclear pore organization	ribosome binding	nuclear envelope|mitochondrion|cytosolic ribosome|endoplasmic reticulum membrane|membrane
YPR060C	YPR060C	ARO7	hom	Verified	1.01564137836356	0.154900096470832	no	768	0.208415140231933	761	NA	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Chorismate mutase, catalyzes the conversion of chorismate to prephenate to initiate the tyrosine/phenylalanine-specific branch of aromatic amino acid biosynthesis	aromatic amino acid family biosynthetic process	chorismate mutase activity	nucleus|cytoplasm
YJL168C	YJL168C	SET2	hom	Verified	1.01480679010972	0.155098968190313	no	769	0.139899905680263	486	NA	FT	CELL CYCLE|CHROMATIN ORGANIZATION	NUCLEUS|CHROMOSOME		Histone methyltransferase with a role in transcriptional elongation; methylates H3 lysine 36, which suppresses incorporation of acetylated histones and signals for the deacetylation of these histones within transcribed genes; associates with the C-terminal domain of Rpo21p; histone methylation activity is regulated by phosphorylation status of Rpo21p	negative regulation of histone H3-K14 acetylation|DNA-dependent transcription, elongation|ascospore formation|regulation of transcription, DNA-dependent|histone deacetylation|regulation of DNA-dependent DNA replication initiation|histone methylation|negative regulation of antisense RNA transcription|Unknown|negative regulation of reciprocal meiotic recombination|positive regulation of histone acetylation	histone methyltransferase activity|histone methyltransferase activity (H3-K36 specific)	nucleus
YGL263W	YGL263W	COS12	hom	Verified	1.0140358795376	0.155282816042012	no	770	0.123914551659515	427	NA					Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins	biological_process	molecular_function	integral to membrane
YDL049C	YDL049C	KNH1	hom	Verified	1.01258968069531	0.155628095454038	no	771	0.143146688330894	479	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM			Protein with similarity to Kre9p, which is involved in cell wall beta 1,6-glucan synthesis; overproduction suppresses growth defects of a kre9 null mutant; required for propionic acid resistance	(1->6)-beta-D-glucan biosynthetic process	molecular_function	fungal-type cell wall|extracellular region
YDR297W	YDR297W	SUR2	hom	Verified	1.01222644298591	0.155714897821124	no	772	0.17099302728507	568	NA	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Sphinganine C4-hydroxylase, catalyses the conversion of sphinganine to phytosphingosine in sphingolipid biosyntheis	sphingolipid metabolic process	sphingosine hydroxylase activity	integral to membrane|endoplasmic reticulum membrane
YHL029C_p	YHL029C	OCA5	hom	Uncharacterized	1.01149207302131	0.155890486609024	no	773	0.185664535705582	661	NA	FT	SIGNALING|NUCLEOTIDE METABOLISM			Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts	biological_process	molecular_function	cytoplasm
YBL037W	YBL037W	APL3	hom	Verified	1.01047570820095	0.156133715975483	no	774	0.152009335711987	520	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|PLASMA MEMBRANE		Alpha-adaptin, large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport	vesicle-mediated transport	molecular_function	AP-2 adaptor complex
YDR408C	YDR408C	ADE8	hom	Verified	1.00995946053726	0.156257356492868	no	775	0.159846947127885	574	NA	FT	NUCLEOTIDE METABOLISM	NUCLEUS		Phosphoribosyl-glycinamide transformylase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway	purine nucleotide biosynthetic process|'de novo' IMP biosynthetic process|adenine biosynthetic process	phosphoribosylglycinamide formyltransferase activity	nucleus|cytoplasm
YGR134W	YGR134W	CAF130	hom	Verified	1.00903444336691	0.156479057956698	no	776	0.141068159909151	517	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Part of the evolutionarily-conserved CCR4-NOT transcriptional regulatory complex involved in controlling mRNA initiation, elongation, and degradation	regulation of transcription from RNA polymerase II promoter|positive regulation of transcription elongation from RNA polymerase II promoter	molecular_function	CCR4-NOT core complex
YER124C	YER124C	DSE1	hom	Verified	1.00798135507283	0.156731706593177	no	777	0.168987100431908	609	NA	FT	CELL CYCLE|SIGNALING|CELL WALL ORG/BIOGENESIS|CELL DIVISION	SITE OF POLARIZED GROWTH		Daughter cell-specific protein, may regulate cross-talk between the mating and filamentation pathways; deletion affects cell separation after division and sensitivity to alpha-factor and drugs affecting the cell wall; relocalizes from bud neck to cytoplasm upon DNA replication stress	cytokinesis, completion of separation|regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion|invasive growth in response to glucose limitation	molecular_function	cellular bud neck
YPL089C	YPL089C	RLM1	hom	Verified	1.00653459583409	0.157079239195346	no	778	0.194341865150571	625	NA	FT	TRANSCRIPTION FROM RNA POL II|SIGNALING	NUCLEUS		MADS-box transcription factor; component of the protein kinase C-mediated MAP kinase pathway involved in the maintenance of cell integrity; phosphorylated and activated by the MAP-kinase Slt2p; RLM1 has a paralog, SMP1, that arose from the whole genome duplication	signal transduction|positive regulation of transcription from RNA polymerase II promoter in response to stress|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity|DNA binding, bending|sequence-specific DNA binding	nucleus
YPL107W_p	YPL107W	YPL107W	hom	Uncharacterized	1.00638862005504	0.157114332827494	no	779	0.150900260762161	526	NA	FT		MITOCHONDRION		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YPL107W is not an essential gene	biological_process	molecular_function	mitochondrion
YOR005C	YOR005C	DNL4	hom	Verified	1.00556970454747	0.157311301627938	no	780	0.138394056878748	474	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CELL DIVISION	NUCLEUS|CHROMOSOME		DNA ligase required for nonhomologous end-joining (NHEJ), forms stable heterodimer with required cofactor Lif1p, interacts with Nej1p; involved in meiosis, not essential for vegetative growth	double-strand break repair via nonhomologous end joining|replicative cell aging	DNA ligase (ATP) activity	DNA ligase IV complex|nuclear chromatin
YNR057C	YNR057C	BIO4	hom	Verified	1.00499460210334	0.157449724536208	no	781	0.175678466730747	639	NA	FT	KETONE METABOLISM|COFACTOR METABOLISM			Dethiobiotin synthetase, catalyzes the third step in the biotin biosynthesis pathway; BIO4 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis; expression appears to be repressed at low iron levels	biotin biosynthetic process	dethiobiotin synthase activity	cytoplasm
YDL026W_d	YDL026W	YDL026W	hom	Dubious	1.00217683244964	0.158129097507187	no	782	0.169532565246042	584	NA					Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDL192W	YDL192W	ARF1	hom	Verified	1.00211764861305	0.158143387512948	no	783	0.188812023695449	657	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING|RESPONSE TO NUTRIENT LEVELS	GOLGI APPARATUS		ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated vesicle formation in intracellular trafficking within the Golgi; ARF1 has a paralog, ARF2, that arose from the whole genome duplication	ER to Golgi vesicle-mediated transport|Golgi to plasma membrane transport|intra-Golgi vesicle-mediated transport|macroautophagy	GTPase activity	cytosol|Golgi-associated vesicle
YDR085C	YDR085C	AFR1	hom	Verified	1.00195332591218	0.158183067862457	no	784	0.152005072719559	547	NA	FT	SIGNALING			Protein required for pheromone-induced projection (shmoo) formation; regulates septin architecture during mating; has an RVXF motif that mediates targeting of Glc7p to mating projections; interacts with Cdc12p; AFR1 has a paralog, YER158C, that arose from the whole genome duplication	regulation of G-protein coupled receptor protein signaling pathway|pheromone-dependent signal transduction involved in conjugation with cellular fusion|cell morphogenesis involved in conjugation with cellular fusion|cell morphogenesis involved in conjugation	receptor signaling protein activity	mating projection base
YLR313C	YLR313C	SPH1	hom	Verified	0.999084906186527	0.158876781157233	no	785	0.178323152566599	623	NA	FT	CELL CYCLE|SIGNALING|CELL DIVISION|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Protein involved in shmoo formation and bipolar bud site selection; homologous to Spa2p, localizes to sites of polarized growth in a cell cycle dependent- and Spa2p-dependent manner, interacts with MAPKKs Mkk1p, Mkk2p, and Ste7p	bipolar cellular bud site selection|pseudohyphal growth|invasive filamentous growth|mating projection assembly	molecular_function	incipient cellular bud site|cellular bud neck|cellular bud tip|mating projection
YOL132W	YOL132W	GAS4	hom	Verified	0.997295469941388	0.1593105559735	no	786	0.146417838562724	514	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	PLASMA MEMBRANE		1,3-beta-glucanosyltransferase, involved with Gas2p in spore wall assembly; has similarity to Gas1p; localizes to the cell wall	ascospore wall assembly	1,3-beta-glucanosyltransferase activity	fungal-type cell wall|integral to membrane
YCL005W-A	YCL005W-A	VMA9	hom	Verified	0.996066076801836	0.159609020512516	no	787	0.191783739316184	669	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|CELL WALL ORG/BIOGENESIS|ION HOMEOSTASIS			Vacuolar H+ ATPase subunit e of the V-ATPase V0 subcomplex; essential for vacuolar acidification; interacts with the V-ATPase assembly factor Vma21p in the ER; involved in V0 biogenesis	cell wall mannoprotein biosynthetic process|vacuolar acidification|protein complex assembly|transmembrane transport	ATPase activity, coupled to transmembrane movement of ions	vacuolar proton-transporting V-type ATPase, V0 domain|fungal-type vacuole membrane
YOL011W	YOL011W	PLB3	hom	Verified	0.995978211953798	0.159630365805087	no	788	0.139221751084834	496	NA	FT	LIPID METABOLISM	PLASMA MEMBRANE		Phospholipase B (lysophospholipase) involved in phospholipid metabolism; hydrolyzes phosphatidylinositol and phosphatidylserine and displays transacylase activity in vitro	phosphatidylinositol metabolic process|phosphatidylserine catabolic process	lysophospholipase activity	extracellular region|plasma membrane
YLR287C_p	YLR287C	YLR287C	hom	Uncharacterized	0.995535519077574	0.159737939037466	no	789	0.143975374250749	473	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR287C is not an essential gene	biological_process	molecular_function	cytoplasm
YJR060W	YJR060W	CBF1	hom	Verified	0.995465248151012	0.159755019053221	no	790	0.188518462830119	672	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|LIPID METABOLISM|AMINO ACID METABOLISM|CHROMATIN ORGANIZATION|RESPONSE TO NUTRIENT LEVELS|CHROMOSOME SEGREGATION	NUCLEUS|MITOCHONDRION|CHROMOSOME	KINETOCHORE	Dual function helix-loop-helix protein; binds the motif CACRTG present at several sites including MET gene promoters and centromere DNA element I (CDEI); affects nucleosome positioning at this motif; associates with other transcription factors such as Met4p and Isw1p to mediate transcriptional activation or repression; associates with kinetochore proteins and required for efficient chromosome segregation; protein abundance increases in response to DNA replication stress	regulation of transcription from RNA polymerase II promoter in response to methionine|negative regulation of transcription from RNA polymerase II promoter|methionine biosynthetic process|chromosome segregation|Unknown|chromatin remodeling|negative regulation of ceramide biosynthetic process by negative regulation of transcription from RNA Polymerase II promoter	RNA polymerase II activating transcription factor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II transcription factor binding transcription factor activity|RNA polymerase II repressing transcription factor binding|centromeric DNA binding	chromosome, centromeric region|mitochondrion|nucleus|kinetochore
YLR325C	YLR325C	RPL38	hom	Verified	0.995105339762637	0.159842516934655	no	791	0.182211462257547	588	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L38; homologous to mammalian ribosomal protein L38, no bacterial homolog	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YDR199W_d	YDR199W	YDR199W	hom	Dubious	0.993774439205855	0.160166346460174	no	792	0.184741212221597	641	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VPS64; computationally predicted to have thiol-disulfide oxidoreductase activity	Unknown	Unknown	Unknown
YML017W	YML017W	PSP2	hom	Verified	0.992792185771748	0.160405619410395	no	793	0.184006707274433	675	NA					Asn rich cytoplasmic protein that contains RGG motifs; high-copy suppressor of group II intron-splicing defects of a mutation in MRS2 and of a conditional mutation in POL1 (DNA polymerase alpha); possible role in mitochondrial mRNA splicing	biological_process	molecular_function	cytoplasm
YER118C	YER118C	SHO1	hom	Verified	0.991659802040756	0.16068175318552	no	794	0.153566494266525	502	NA	FT	SIGNALING	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Transmembrane osmosensor involved in activation of the Cdc42p- and MAP kinase-dependent filamentous growth pathway and the high-osmolarity glycerol response pathway; phosphorylated by Hog1p; interacts with Pbs2p, Msb2p, Hkr1p, and Ste11p	signal transduction involved in filamentous growth|establishment of cell polarity|osmosensory signaling pathway|cellular response to heat|cytokinesis	osmosensor activity|MAP-kinase scaffold activity	integral to membrane|plasma membrane|plasma membrane part|cellular bud|cellular bud neck|mating projection tip
YLR083C	YLR083C	EMP70	hom	Verified	0.99153805595152	0.160711459656167	no	795	0.1917424537295	606	NA	FT	VESICLE-MEDIATED TRANSPORT|ION HOMEOSTASIS|ION HOMEOSTASIS|VACUOLAR TRANSPORT			Protein with a role in cellular adhesion, filamentous growth, and endosome-to-vacuole sorting; similar to Tmn2p and Tmn3p; member of Transmembrane Nine family of proteins with 9 transmembrane segments	cellular copper ion homeostasis|vacuolar transport|pseudohyphal growth|endosomal transport|invasive growth in response to glucose limitation	molecular_function	endosome|fungal-type vacuole membrane|integral to membrane
YMR083W	YMR083W	ADH3	hom	Verified	0.991198371990812	0.160794362689926	no	796	0.172197191960944	605	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Mitochondrial alcohol dehydrogenase isozyme III; involved in the shuttling of mitochondrial NADH to the cytosol under anaerobic conditions and ethanol production	NADH oxidation|fermentation|amino acid catabolic process to alcohol via Ehrlich pathway	alcohol dehydrogenase (NAD) activity	mitochondrion|mitochondrial matrix
YMR054W	YMR054W	STV1	hom	Verified	0.988804340732993	0.161379440040684	no	797	0.164226998117236	607	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Subunit a of the vacuolar-ATPase V0 domain, one of two isoforms (Stv1p and Vph1p); Stv1p is located in V-ATPase complexes of the Golgi and endosomes while Vph1p is located in V-ATPase complexes of the vacuole	vacuolar acidification	proton-transporting ATPase activity, rotational mechanism	vacuolar proton-transporting V-type ATPase, V0 domain|late endosome|integral to membrane|Golgi apparatus
YOL136C	YOL136C	PFK27	hom	Verified	0.987345420576401	0.161736665564635	no	798	0.148043315203632	535	NA	FT	CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY			6-phosphofructo-2-kinase, catalyzes synthesis of fructose-2,6-bisphosphate; inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate, expression induced by glucose and sucrose, transcriptional regulation involves protein kinase A	regulation of glycolysis|fructose 2,6-bisphosphate metabolic process	6-phosphofructo-2-kinase activity	cytoplasm
YJL211C_d	YJL211C	YJL211C	hom	Dubious	0.986660267318856	0.161904607232865	no	799	0.160519597701626	543	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL210W/PEX2	Unknown	Unknown	Unknown
YEL024W	YEL024W	RIP1	hom	Verified	0.981215862269669	0.163243151766396	no	800	0.191291098204562	662	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Ubiquinol-cytochrome-c reductase, a Rieske iron-sulfur protein of the mitochondrial cytochrome bc1 complex; transfers electrons from ubiquinol to cytochrome c1 during respiration; during import, Rip1p is first imported into the mitochondrial matrix where it is processed, acquires its Fe-S cluster, and is folded, then is translocated into the inner membrane by the action of a homo-oligomer of Bcs1p, and finally is delivered by Bcs1p to Complex III for assembly	mitochondrial electron transport, ubiquinol to cytochrome c|aerobic respiration	ubiquinol-cytochrome-c reductase activity	mitochondrion|mitochondrial respiratory chain complex III
YAR031W	YAR031W	PRM9	hom	Verified	0.980319462731365	0.163464225236125	no	801	0.168149523040791	538	NA	FT	VESICLE-MEDIATED TRANSPORT	ENDOPLASMIC RETICULUM|PLASMA MEMBRANE		Pheromone-regulated protein with 3 predicted transmembrane segments and an FF sequence, a motif involved in COPII binding; member of DUP240 gene family	vesicle organization	molecular_function	integral to membrane|endoplasmic reticulum|plasma membrane
YML102W	YML102W	CAC2	hom	Verified	0.978063732314451	0.164021401964183	no	802	0.166663867470878	574	NA	FT	CHROMATIN ORGANIZATION	NUCLEUS|CHROMOSOME		Subunit of chromatin assembly factor I (CAF-1), with Rlf2p and Msi1p; chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of the DNA damage checkpoint after DNA repair; and chromatin dynamics during transcription	DNA replication-dependent nucleosome assembly	histone binding	chromosome, centromeric region|CAF-1 complex
YMR179W	YMR179W	SPT21	hom	Verified	0.977968324761919	0.164044995234918	no	803	0.177266730422672	647	NA	FT	TRANSCRIPTION FROM RNA POL II|GENE SILENCING	NUCLEUS		Protein with a role in transcriptional silencing; required for normal transcription at several loci including HTA2-HTB2 and HHF2-HHT2, but not required at the other histone loci; functionally related to Spt10p; localizes to nuclear foci that become diffuse upon DNA replication stress	chromatin silencing at rDNA|regulation of transcription from RNA polymerase II promoter|chromatin silencing at telomere|chromatin silencing at silent mating-type cassette	molecular_function	nucleus
YOR030W	YOR030W	DFG16	hom	Verified	0.975129536451563	0.164748004543625	no	804	0.201392904376947	745	NA	FF|FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Probable multiple transmembrane protein; involved in diploid invasive and pseudohyphal growth upon nitrogen starvation; is glycosylated and phosphorylated; interacts with Rim21p and Rim9p in the plasma membrane to form a pH-sensing complex in the Rim101 pathway and is required to maintain Rim21p levels; required for accumulation of processed Rim101p	pseudohyphal growth|protein processing	molecular_function	integral to membrane
YMR303C	YMR303C	ADH2	hom	Verified	0.975103974354807	0.164754343700549	no	805	0.162562586869594	547	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM			Glucose-repressible alcohol dehydrogenase II, catalyzes the conversion of ethanol to acetaldehyde; involved in the production of certain carboxylate esters; regulated by ADR1	ethanol metabolic process|NADH oxidation|fermentation|amino acid catabolic process to alcohol via Ehrlich pathway	alcohol dehydrogenase (NAD) activity	cytoplasm
YAL028W	YAL028W	FRT2	hom	Verified	0.974970229311208	0.164787513775736	no	806	0.122152744528507	420	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Tail-anchored ER membrane protein of unknown function; interacts with homolog Frt1p; promotes growth in conditions of high Na+, alkaline pH, or cell wall stress, possibly via a role in posttranslational translocation; potential Cdc28p substrate; FRT2 has a paralog, FRT1, that arose from the whole genome duplication	response to stress	molecular_function	endoplasmic reticulum
YGL101W_p	YGL101W	YGL101W	hom	Uncharacterized	0.974818388883858	0.164825176925596	no	807	0.167231969462357	501	NA	FT		NUCLEUS		Putative protein of unknown function; non-essential gene with similarity to YBR242W; interacts with the DNA helicase Hpr5p	biological_process	molecular_function	nucleus|cytoplasm
YPR189W	YPR189W	SKI3	hom	Verified	0.974116955174989	0.164999235911255	no	808	0.144425789689412	544	NA	FT		NUCLEUS		Ski complex component and TPR protein, mediates 3'-5' RNA degradation by the cytoplasmic exosome; null mutants have superkiller phenotype of increased viral dsRNAs and are synthetic lethal with mutations in 5'-3' mRNA decay	nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'|nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay|nuclear-transcribed mRNA catabolic process, non-stop decay	molecular_function	Ski complex
YGL168W	YGL168W	HUR1	hom	Verified	0.973755543184569	0.165088965817198	no	809	0.236911944638653	795	NA	FF|FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS			Protein of unknown function; reported null mutant phenotype of hydroxyurea sensitivity may be due to effects on overlapping PMR1 gene	DNA replication	molecular_function	cellular_component
YDL021W	YDL021W	GPM2	hom	Verified	0.972760086953032	0.165336276960544	no	810	0.171951075291862	586	NA	FT	CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY			Homolog of Gpm1p phosphoglycerate mutase, which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event	biological_process	phosphoglycerate mutase activity|molecular_function	cytosol|cytoplasm
YDL076C	YDL076C	RXT3	hom	Verified	0.972709032869891	0.165348967296169	no	811	0.178384634711144	591	NA	FT	CHROMATIN ORGANIZATION	NUCLEUS|CHROMOSOME		Subunit of the RPD3L complex; involved in histone deacetylation; protein abundance increases in response to DNA replication stress	negative regulation of transcription from RNA polymerase I promoter	molecular_function	Rpd3L-Expanded complex|nucleus|Rpd3L complex
YCR008W	YCR008W	SAT4	hom	Verified	0.972685139670792	0.165354906561938	no	812	0.163262940315058	603	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|ION HOMEOSTASIS|PROTEIN PHOSPHORYLATION|ION HOMEOSTASIS			Ser/Thr protein kinase involved in salt tolerance; funtions in regulation of Trk1p-Trk2p potassium transporter; partially redundant with Hal5p; has similarity to Npr1p	cellular cation homeostasis|protein phosphorylation|cellular protein localization|G1/S transition of mitotic cell cycle|protein dephosphorylation	protein kinase activity	cellular_component
YOL017W	YOL017W	ESC8	hom	Verified	0.971938454551914	0.165540583805877	no	813	0.168210654070987	577	NA	FT	GENE SILENCING	NUCLEUS		Protein involved in telomeric and mating-type locus silencing; interacts with Sir2p and also interacts with Gal11p, which is a component of the RNA pol II mediator complex; ESC8 has a paralog, IOC3, that arose from the whole genome duplication	chromatin silencing	molecular_function	nucleus
YLR292C	YLR292C	SEC72	hom	Verified	0.970188413783218	0.165976292429706	no	814	0.187306033101733	613	NA	FT	PROTEIN LOCALIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER	posttranslational protein targeting to membrane, translocation	protein transporter activity	Sec62/Sec63 complex|endoplasmic reticulum membrane
YOR308C	YOR308C	SNU66	hom	Verified	0.96985190742888	0.16606015747834	no	815	0.167332722065148	600	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Component of the U4/U6.U5 snRNP complex involved in pre-mRNA splicing via spliceosome; also required for pre-5S rRNA processing and may act in concert with Rnh70p; has homology to human SART-1	maturation of 5S rRNA|mRNA splicing, via spliceosome	molecular_function	U4/U6 x U5 tri-snRNP complex
YGR275W	YGR275W	RTT102	hom	Verified	0.969095354168384	0.166248807741153	no	816	0.182627867623221	563	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|CHROMOSOME SEGREGATION	NUCLEUS	RSC COMPLEX	Component of both the SWI/SNF and RSC chromatin remodeling complexes; suggested role in chromosome maintenance; possible weak regulator of Ty1 transposition; protein abundance increases in response to DNA replication stress	chromosome segregation|nucleosome disassembly|chromatin remodeling|transcription elongation from RNA polymerase II promoter	molecular_function	RSC complex|SWI/SNF complex|nucleus
YOR312C	YOR312C	RPL20B	hom	Verified	0.96817263352937	0.16647907993944	no	817	0.140114595039669	493	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L20B; homologous to mammalian ribosomal protein L18A, no bacterial homolog; RPL20B has a paralog, RPL20A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YLR138W	YLR138W	NHA1	hom	Verified	0.967734217162206	0.166588562318914	no	818	0.151759184687204	521	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Na+/H+ antiporter involved in sodium and potassium efflux through the plasma membrane; required for alkali cation tolerance at acidic pH	cellular potassium ion homeostasis|cellular monovalent inorganic cation homeostasis|response to osmotic stress	cation:cation antiporter activity|sodium:hydrogen antiporter activity	membrane raft|integral to membrane|plasma membrane
YBR221W-A_p	YBR221W-A	YBR221W-A	hom	Uncharacterized	0.967302863409012	0.166696326348979	no	819	0.157130518427288	523	NA					Putative protein of unknown function; identified by expression profiling and mass spectrometry	biological_process	molecular_function	cellular_component
YMR289W	YMR289W	ABZ2	hom	Verified	0.966372511382357	0.166928906975435	no	820	0.178401220040604	651	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM			Aminodeoxychorismate lyase (4-amino-4-deoxychorismate lyase), catalyzes the third step in para-aminobenzoic acid biosynthesis; involved in folic acid biosynthesis	folic acid biosynthetic process	4-amino-4-deoxychorismate lyase activity	cytoplasm
YKL009W	YKL009W	MRT4	hom	Verified	0.965049809385647	0.167259932117317	no	821	0.181485392748036	614	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Protein involved in mRNA turnover and ribosome assembly, localizes to the nucleolus	nuclear-transcribed mRNA catabolic process|ribosomal large subunit assembly|ribosomal large subunit biogenesis|rRNA processing	LSU rRNA binding	nucleoplasm|nucleolus|nucleus|preribosome, large subunit precursor
YOL100W	YOL100W	PKH2	hom	Verified	0.964912552763265	0.167294306770151	no	822	0.167545604023079	583	NA	FT	VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|RNA PROCESSING|SIGNALING|CELL WALL ORG/BIOGENESIS|PROTEIN PHOSPHORYLATION	NUCLEUS		Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; redundant with Pkh1p	regulation of nuclear-transcribed mRNA poly(A) tail shortening|protein phosphorylation|MAPK cascade involved in cell wall biogenesis|cytoplasmic mRNA processing body assembly	protein kinase activity	cell cortex|eisosome|nucleus
YNL170W_d	YNL170W	YNL170W	hom	Dubious	0.964011276806306	0.167520136105606	no	823	0.18055879995027	658	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDR386W	YDR386W	MUS81	hom	Verified	0.963274459697341	0.167704903440014	no	824	0.213362848867532	736	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION	NUCLEUS		Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in DNA repair, replication fork stability, and joint molecule formation/resolution during meiotic recombination; helix-hairpin-helix protein; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates the function of Mms4p-Mus81p	DNA repair|DNA topological change|reciprocal meiotic recombination|resolution of meiotic recombination intermediates|response to DNA damage stimulus	crossover junction endodeoxyribonuclease activity|endonuclease activity	Holliday junction resolvase complex|nucleus
YDL231C	YDL231C	BRE4	hom	Verified	0.960353589289479	0.168438643824939	no	825	0.172059746140727	577	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION			Zinc finger protein containing five transmembrane domains; null mutant exhibits strongly fragmented vacuoles and sensitivity to brefeldin A, a drug which is known to affect intracellular transport	endocytosis	molecular_function	integral to membrane
YIL037C	YIL037C	PRM2	hom	Verified	0.960042913938593	0.168516808639483	no	826	0.174285754230056	633	NA					Pheromone-regulated protein, predicted to have 4 transmembrane segments and a coiled coil domain; regulated by Ste12p; required for efficient nuclear fusion	karyogamy involved in conjugation with cellular fusion	molecular_function	integral to membrane
YBR215W	YBR215W	HPC2	hom	Verified	0.959882979440667	0.168557056682446	no	827	0.167873382630406	596	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION	NUCLEUS		Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; mutants display synthetic defects with subunits of FACT, a complex that allows passage of RNA Pol II through nucleosomes	DNA replication-independent nucleosome assembly|regulation of transcription involved in G1/S phase of mitotic cell cycle|transcription elongation from RNA polymerase II promoter	nucleosome binding|DNA binding	HIR complex|nucleus
YBR248C	YBR248C	HIS7	hom	Verified	0.959500732969899	0.1686532752981	no	828	0.156836080176836	542	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEOTIDE METABOLISM			Imidazole glycerol phosphate synthase (glutamine amidotransferase:cyclase), catalyzes the fifth step of histidine biosynthesis and also produces 5-aminoimidazole-4-carboxamide ribotide (AICAR), a purine precursor	purine nucleoside monophosphate biosynthetic process|histidine biosynthetic process	imidazoleglycerol-phosphate synthase activity	intracellular
YML050W	YML050W	AIM32	hom	Verified	0.955354623160392	0.169699196496909	no	829	0.189342265855734	638	NA					Putative protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss	biological_process	molecular_function	cellular_component
YOR081C	YOR081C	TGL5	hom	Verified	0.954946290567735	0.169802429364729	no	830	0.149210797947661	498	NA	FT	LIPID METABOLISM			Bifunctional enzyme with triacylglycerol lipase and lysophosphatidic acid acyltransferase activity; involved in triacylglycerol mobilization; localizes to lipid particles; potential Cdc28p substrate	triglyceride mobilization	lysophosphatidic acid acyltransferase activity|triglyceride lipase activity	lipid particle
YKL031W_d	YKL031W	YKL031W	hom	Dubious	0.953266406382217	0.170227553890142	no	831	0.176069749398221	568	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species	Unknown	Unknown	Unknown
YBL038W	YBL038W	MRPL16	hom	Verified	0.952345060052017	0.170461006262519	no	832	0.197562947993111	681	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation	structural constituent of ribosome|peptidyltransferase activity	mitochondrion|mitochondrial large ribosomal subunit
YPR121W	YPR121W	THI22	hom	Verified	0.952278656347723	0.17047783966864	no	833	0.147110926053489	502	NA					Protein with similarity to hydroxymethylpyrimidine phosphate kinases; member of a gene family with THI20 and THI21; not required for thiamine biosynthesis	thiamine biosynthetic process	phosphomethylpyrimidine kinase activity|hydroxymethylpyrimidine kinase activity	cellular_component
YAR018C	YAR018C	KIN3	hom	Verified	0.952214668771844	0.170494061590865	no	834	0.18935957997435	629	NA	FT	PROTEIN PHOSPHORYLATION|CHROMOSOME SEGREGATION			Nonessential serine/threonine protein kinase; possible role in DNA damage response	chromosome segregation|protein phosphorylation	protein kinase activity	cellular_component
YOR376W_d	YOR376W	YOR376W	hom	Dubious	0.949590834843286	0.171160098625305	no	835	0.151183195700174	479	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YOR376W is not an essential gene.	Unknown	Unknown	Unknown
YBR125C	YBR125C	PTC4	hom	Verified	0.949536788092299	0.171173835381605	no	836	0.143348796413691	497	NA					Cytoplasmic type 2C protein phosphatase (PP2C); identified as a high-copy number suppressor of cnb1 mpk1 synthetic lethality; overexpression decreases high-osmolarity induced Hog1p phosphorylation and kinase activity	protein dephosphorylation	protein serine/threonine phosphatase activity	cytoplasm
YDR101C	YDR101C	ARX1	hom	Verified	0.948854615722251	0.171347279869298	no	837	0.183143205138626	596	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|PROTEOLYSIS	NUCLEUS	RIBOSOME	Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex	ribosomal large subunit biogenesis	molecular_function	nucleoplasm|cytosolic large ribosomal subunit|cytoplasm
YDR181C	YDR181C	SAS4	hom	Verified	0.947939637117251	0.171580092411787	no	838	0.212039440707698	721	NA	FT	CHROMATIN ORGANIZATION|PROTEOLYSIS|GENE SILENCING	NUCLEUS|CHROMOSOME	HISTONE ACETYLTRANSFERASE	Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; required for the HAT activity of Sas2p	chromatin silencing at telomere	acetyltransferase activity|histone acetyltransferase activity	nuclear chromatin|SAS acetyltransferase complex|nuclear chromosome, telomeric region
YBR111W-A	YBR111W-A	SUS1	hom	Verified	0.947244352078753	0.171757139912016	no	839	0.227099332474589	764	NA	FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE|HISTONE ACETYLTRANSFERASE	Component of both the SAGA histone acetylase and TREX-2 complexes; interacts with RNA polymerase II; involved in mRNA export coupled transcription activation and elongation; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP	poly(A)+ mRNA export from nucleus|regulation of protein localization|nuclear retention of pre-mRNA at the site of transcription|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|histone deubiquitination|histone H3-K4 methylation|transcription elongation from RNA polymerase II promoter|histone H3-K79 methylation|positive regulation of transcription from RNA polymerase II promoter	enzyme activator activity	DUBm complex|nucleoplasm|transcription export complex 2|SAGA complex|nuclear pore
YJR131W	YJR131W	MNS1	hom	Verified	0.945541104292997	0.172191348061332	no	840	0.17518391529064	550	NA	FT	CARBOHYDRATE METABOLISM|PROTEOLYSIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Alpha-1,2-mannosidase involved in ER-associated protein degradation (ERAD); catalyzes the removal of one mannose residue from a glycosylated protein, converting the modification from Man9GlcNAc to Man8GlcNAc; catalyzes the last step in glycoprotein maturation in the ER and is critical for ER protein degradation	ER-associated protein catabolic process|protein deglycosylation involved in glycoprotein catabolic process	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	endoplasmic reticulum
YCR032W	YCR032W	BPH1	hom	Verified	0.944694035679172	0.1724075514443	no	841	0.174836783634273	629	NA	FT	PROTEIN LOCALIZATION|CELL WALL ORG/BIOGENESIS	MITOCHONDRION		Protein homologous to Chediak-Higashi syndrome and Beige proteins; both of which are implicated in disease syndromes in human and mouse, respectively, due to defective lysosomal trafficking; mutant phenotype and genetic interactions suggest a role in protein sorting	intracellular protein transport|fungal-type cell wall organization|response to pH	molecular_function	cytosol|mitochondrion|extrinsic to membrane
YLR299W	YLR299W	ECM38	hom	Verified	0.944470241675395	0.172464700893989	no	842	0.154250749465234	526	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Gamma-glutamyltranspeptidase, major glutathione-degrading enzyme; involved in detoxification of electrophilic xenobiotics; expression induced mainly by nitrogen starvation	xenobiotic metabolic process|glutathione catabolic process	gamma-glutamyltransferase activity	fungal-type vacuole
YLL045C	YLL045C	RPL8B	hom	Verified	0.942858650400773	0.172876603735837	no	843	0.159154457582572	565	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L8B; mutation results in decreased amounts of free 60S subunits; homologous to mammalian ribosomal protein L7A, no bacterial homolog; RPL8B has a paralog, RPL8A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YDL095W	YDL095W	PMT1	hom	Verified	0.942507032663996	0.172966556132712	no	844	0.205702462903635	672	NA	FT	PROTEIN LOCALIZATION|CARBOHYDRATE METABOLISM|PROTEOLYSIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein O-mannosyltransferase of the ER membrane; transfers mannose from dolichyl phosphate-D-mannose to protein serine and threonine residues; 1 of 7 related proteins involved in O-glycosylation which is essential for cell wall rigidity; involved in ER quality control; amino terminus faces cytoplasm, carboxyl terminus faces ER lumen	ER-associated misfolded protein catabolic process|Unknown|protein exit from endoplasmic reticulum|protein O-linked mannosylation	dolichyl-phosphate-mannose-protein mannosyltransferase activity	integral to membrane|dolichyl-phosphate-mannose-protein mannosyltransferase complex
YJL215C_d	YJL215C	YJL215C	hom	Dubious	0.942417376678844	0.172989497091867	no	845	0.187931833682285	614	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YJL176C	YJL176C	SWI3	hom	Verified	0.942090390150575	0.173073182049859	no	846	0.203664794404994	687	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS	NUCLEUS	RSC COMPLEX	Subunit of the SWI/SNF chromatin remodeling complex; SWI/SNF regulates transcription by remodeling chromosomes; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2; relocates to the cytosol under hypoxic conditions	cellular alcohol catabolic process|ATP-dependent chromatin remodeling|positive regulation of mating type switching|sucrose catabolic process|carbon catabolite activation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter	histone binding|DNA binding	SWI/SNF complex|nucleus
YJR062C	YJR062C	NTA1	hom	Verified	0.940261380556963	0.173541751964303	no	847	0.151325155381554	542	NA	FT	PROTEOLYSIS	MITOCHONDRION		Amidase, removes the amide group from N-terminal asparagine and glutamine residues to generate proteins with N-terminal aspartate and glutamate residues that are targets of ubiquitin-mediated degradation	cellular protein modification process|protein catabolic process	protein-N-terminal asparagine amidohydrolase activity	mitochondrion
YMR081C	YMR081C	ISF1	hom	Verified	0.938345319960263	0.174033488286131	no	848	0.157650308868931	586	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY			Serine-rich, hydrophilic protein with similarity to Mbr1p; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; expression is under glucose control; cotranscribed with NAM7 in a cyp1 mutant	aerobic respiration	molecular_function	cellular_component
YBL059W_p	YBL059W	YBL059W	hom	Uncharacterized	0.938294670802106	0.174046498853082	no	849	0.191956463353234	648	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YBL059W has a paralog, YER093C-A, that arose from the whole genome duplication	biological_process	molecular_function	mitochondrion
YGL124C	YGL124C	MON1	hom	Verified	0.93791539242942	0.174143946118966	no	850	0.190663264955106	641	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT			Protein required for fusion of cvt-vesicles and autophagosomes with the vacuole; associates, as a complex with Ccz1p, with a perivacuolar compartment; potential Cdc28p substrate	autophagy|vesicle docking|protein targeting to vacuole	molecular_function	cytosol|fungal-type vacuole membrane|Mon1-Ccz1 complex
YPL047W	YPL047W	SGF11	hom	Verified	0.935146698924144	0.174856351465928	no	851	0.169996437160195	614	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION	NUCLEUS	HISTONE ACETYLTRANSFERASE	Integral subunit of SAGA histone acetyltransferase complex, regulates transcription of a subset of SAGA-regulated genes, required for the Ubp8p association with SAGA and for H2B deubiquitylation	histone deubiquitination|regulation of transcription from RNA polymerase II promoter	enzyme activator activity	DUBm complex|nucleus|SAGA complex
YPL274W	YPL274W	SAM3	hom	Verified	0.934398474929353	0.175049192069731	no	852	0.209684461146165	634	NA	FT		ENDOPLASMIC RETICULUM|PLASMA MEMBRANE		High-affinity S-adenosylmethionine permease, required for utilization of S-adenosylmethionine as a sulfur source; has similarity to S-methylmethionine permease Mmp1p	spermidine transport|putrescine transport|S-adenosylmethionine transport	S-adenosylmethionine transmembrane transporter activity|spermidine transmembrane transporter activity|putrescine transmembrane transporter activity	integral to membrane|plasma membrane
YFL001W	YFL001W	DEG1	hom	Verified	0.934201588073226	0.175099958353125	no	853	0.205565462975129	662	NA	FT	RNA PROCESSING	NUCLEUS		tRNA:pseudouridine synthase, introduces pseudouridines at position 38 or 39 in tRNA, important for maintenance of translation efficiency and normal cell growth, localizes to both the nucleus and cytoplasm; non-essential for viability	tRNA pseudouridine synthesis	pseudouridine synthase activity	nucleus|cytoplasm
YDR432W	YDR432W	NPL3	hom	Verified	0.933878696840477	0.175183234445209	no	854	0.205847333526698	732	NA	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION	NUCLEUS		RNA-binding protein; promotes elongation, regulates termination, and carries poly(A) mRNA from nucleus to cytoplasm; has a role in repressing translation initiation by binding eIF4G; required for pre-mRNA splicing; dissociation from mRNAs promoted by Mtr10p; phosphorylated by Sky1p in the cytoplasm; protein abundance increases in response to DNA replication stress	translational termination|mRNA export from nucleus|negative regulation of translation|mRNA splicing, via spliceosome|Unknown|positive regulation of transcription elongation from RNA polymerase II promoter	mRNA binding|RNA polymerase II core binding|eukaryotic initiation factor 4G binding|poly(A) RNA binding	nucleus|cytoplasm
YGL213C	YGL213C	SKI8	hom	Verified	0.933113529164016	0.175380677253057	no	855	0.161805270861082	558	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE	NUCLEUS|CHROMOSOME		Ski complex component and WD-repeat protein, mediates 3'-5' RNA degradation by the cytoplasmic exosome; also required for meiotic double-strand break recombination; null mutants have superkiller phenotype	nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'|nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay|protein complex assembly|nuclear-transcribed mRNA catabolic process, non-stop decay|protein-DNA complex assembly|reciprocal meiotic recombination	molecular_function	Ski complex|nuclear chromosome
YKL003C	YKL003C	MRP17	hom	Verified	0.932118482002195	0.175637648780177	no	856	0.18503065077458	607	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the small subunit; MRP17 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YHR066W	YHR066W	SSF1	hom	Verified	0.930889566540259	0.17595534603676	no	857	0.162242938737241	579	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS	NUCLEUS		Constituent of 66S pre-ribosomal particles; required for ribosomal large subunit maturation; functionally redundant with Ssf2p; member of the Brix family; SSF1 has a paralog, SSF2, that arose from the whole genome duplication	conjugation with cellular fusion|ribosomal large subunit assembly|regulation of cell size	rRNA binding	nucleolus
YPR059C_d	YPR059C	YPR059C	hom	Dubious	0.929728891249054	0.176255735874695	no	858	0.190024461132485	704	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YMC1/YPR058W	Unknown	Unknown	Unknown
YGR127W_p	YGR127W	YGR127W	hom	Uncharacterized	0.929404371697535	0.176339781532003	no	859	0.154540386168868	538	NA					Putative protein of unknown function; expression is regulated by Msn2p/Msn4p, indicating a possible role in stress response	biological_process	molecular_function	cellular_component
YNL295W_p	YNL295W	YNL295W	hom	Uncharacterized	0.929058670071208	0.176429340915478	no	860	0.147034887003151	509	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YGL194C	YGL194C	HOS2	hom	Verified	0.927752232118429	0.176768053769048	no	861	0.165976233611755	584	NA	FT	CELL CYCLE|CHROMATIN ORGANIZATION|SIGNALING	NUCLEUS|CHROMOSOME		Histone deacetylase and subunit of Set3 and Rpd3L complexes; required for gene activation via specific deacetylation of lysines in H3 and H4 histone tails; subunit of the Set3 complex, a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity; co-localizes with Cmr1p in nuclear foci in response to DNA damage by MMS	negative regulation of meiosis|chromatin organization|regulation of transcription, DNA-dependent|positive regulation of stress-activated MAPK cascade|histone deacetylation	NAD-independent histone deacetylase activity|NAD-dependent histone deacetylase activity	Rpd3L-Expanded complex|Set3 complex
YHR192W	YHR192W	LNP1	hom	Verified	0.927406703224917	0.176857705804077	no	862	0.223898739364019	764	NA					Lunapark family member involved in ER network formation; localizes to ER junctions and this localization is regulated by the yeast atlastin ortholog Sey1p; interacts with the reticulon protein Rtn1p; induced in response to the DNA-damaging agent MMS	endoplasmic reticulum tubular network organization	molecular_function	endoplasmic reticulum tubular network|cytoplasm
YCR002C	YCR002C	CDC10	hom	Verified	0.927265707776567	0.176894297190033	no	863	0.202477617174529	728	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Component of the septin ring, required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins between mother and daughter cells; N-terminus interacts with phosphatidylinositol-4,5-bisphosphate; protein abundance increases under DNA damage stress	sporulation|maintenance of cell polarity|exit from mitosis|cell cycle cytokinesis|septin ring assembly	protein complex scaffold|structural molecule activity|GTP binding|GTPase activity|1-phosphatidylinositol binding	spindle microtubule|ascospore-type prospore|septin complex|prospore membrane|mating projection base|meiotic spindle|septin filament array|cellular bud neck septin ring|mating projection tip
YNL076W	YNL076W	MKS1	hom	Verified	0.923352943896235	0.177911652777891	no	864	0.165954209789451	590	NA	FT	TRANSCRIPTION FROM RNA POL II|SIGNALING	NUCLEUS		Pleiotropic negative transcriptional regulator involved in Ras-CAMP and lysine biosynthetic pathways and nitrogen regulation; involved in retrograde (RTG) mitochondria-to-nucleus signaling	regulation of nitrogen utilization|negative regulation of transcription from RNA polymerase II promoter|Unknown|mitochondria-nucleus signaling pathway	molecular_function	cytoplasm
YDR214W	YDR214W	AHA1	hom	Verified	0.922779259348492	0.178061125755938	no	865	0.189216071005535	626	NA	FT	NUCLEOTIDE METABOLISM			Co-chaperone that binds to Hsp82p and activates its ATPase activity; similar to Hch1p; expression is regulated by stresses such as heat shock; protein abundance increases in response to DNA replication stress	protein folding|response to stress	ATPase activator activity|chaperone binding	cytoplasm
YJL170C	YJL170C	ASG7	hom	Verified	0.921781567021188	0.178321262080757	no	866	0.188318033477416	657	NA	FT		ENDOMEMBRANE SYSTEM|PLASMA MEMBRANE		Protein that regulates signaling from a G protein beta subunit Ste4p and its relocalization within the cell; specific to a-cells and induced by alpha-factor	conjugation with cellular fusion	molecular_function	plasma membrane
YLR252W_d	YLR252W	YLR252W	hom	Dubious	0.921417491962116	0.178416249900696	no	867	0.192797909096548	654	NA					Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene SYM1, a mitochondrial protein involved in ethanol metabolism	Unknown	Unknown	Unknown
YPR049C	YPR049C	ATG11	hom	Verified	0.920993980675536	0.178526784835803	no	868	0.193262173167241	654	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|PEROXISOME ORGANIZATION			Adapter protein for pexophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; directs receptor-bound cargo to the phagophore assembly site (PAS) for packaging into vesicles; required for recruiting other proteins to the (PAS)	piecemeal microautophagy of nucleus|mitochondrion degradation|peroxisome degradation|protein localization to pre-autophagosomal structure|CVT pathway	protein complex scaffold	pre-autophagosomal structure|extrinsic to membrane
YER038W-A_d	YER038W-A	YER038W-A	hom	Dubious	0.920908392684281	0.178549128234271	no	869	0.185140983440164	598	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 99% of ORF overlaps the verified gene HVG1; protein product detected in mitochondria	Unknown	Unknown	Unknown
YGL108C	YGL108C	YGL108C	hom	Verified	0.920734197396595	0.178594608683702	no	870	0.171980860789944	617	NA					Protein of unknown function, predicted to be palmitoylated; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	cellular_component
YBR146W	YBR146W	MRPS9	hom	Verified	0.91999406751634	0.178787929695314	no	871	0.190604230934364	650	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the small subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YPL133C	YPL133C	RDS2	hom	Verified	0.917764052043295	0.179371203004436	no	872	0.147765630121458	500	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|SIGNALING|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Transcription factor involved in regulating gluconeogenesis and glyoxylate cycle genes; member of the zinc cluster family of proteins; confers resistance to ketoconazole	positive regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source|positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter|cellular response to xenobiotic stimulus|positive regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus|cytoplasm
YPR166C	YPR166C	MRP2	hom	Verified	0.917541183763588	0.179429561166254	no	873	0.20643390470579	664	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the small subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YHL033C	YHL033C	RPL8A	hom	Verified	0.915437374396908	0.179981032634486	no	874	0.176628709620963	600	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L8A; mutation results in decreased amounts of free 60S subunits; homologous to mammalian ribosomal protein L7A, no bacterial homolog; RPL8A has a paralog, RPL8B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YBR191W	YBR191W	RPL21A	hom	Verified	0.912598939514479	0.180726756141473	no	875	0.196708865904948	656	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L21A; homologous to mammalian ribosomal protein L21, no bacterial homolog; RPL21A has a paralog, RPL21B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YJL096W	YJL096W	MRPL49	hom	Verified	0.912234010709384	0.180822771852428	no	876	0.205767486614861	693	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YOR318C_d	YOR318C	YOR318C	hom	Dubious	0.910269529439879	0.181340191917592	no	877	0.173645799062335	610	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcript is predicted to be spliced but there is no evidence that it is spliced in vivo	Unknown	Unknown	Unknown
YOR332W	YOR332W	VMA4	hom	Verified	0.909240455795705	0.181611606828839	no	878	0.197300192305997	658	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Subunit E of the V1 domain of the vacuolar H+-ATPase (V-ATPase); V-ATPase is an electrogenic proton pump found throughout the endomembrane system; V1 domain has eight subunits; required for the V1 domain to assemble onto the vacuolar membrane; protein abundance increases in response to DNA replication stress	vacuolar acidification	proton-transporting ATPase activity, rotational mechanism	vacuolar proton-transporting V-type ATPase, V1 domain|fungal-type vacuole membrane|integral to membrane
YMR228W	YMR228W	MTF1	hom	Verified	0.909218285711255	0.181617456914332	no	879	0.169194725976935	612	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation	transcription initiation from mitochondrial promoter	mitochondrial RNA polymerase binding promoter specificity activity	mitochondrion|mitochondrial DNA-directed RNA polymerase complex|mitochondrial matrix|mitochondrial intermembrane space
YJL103C	YJL103C	GSM1	hom	Verified	0.90903149439866	0.1816667507705	no	880	0.1877780719835	634	NA	FT	TRANSCRIPTION FROM RNA POL II|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS		Putative zinc cluster protein of unknown function; proposed to be involved in the regulation of energy metabolism, based on patterns of expression and sequence analysis	oxidative phosphorylation	sequence-specific DNA binding|DNA binding	cellular_component
YGR269W_d	YGR269W	YGR269W	hom	Dubious	0.908894340667635	0.181702950697235	no	881	0.190798267733811	658	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF HUA1/YGR268C	Unknown	Unknown	Unknown
YPR194C	YPR194C	OPT2	hom	Verified	0.908737849431834	0.18174426001666	no	882	0.180570260963978	640	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION	PLASMA MEMBRANE		Oligopeptide transporter; member of the OPT family, with potential orthologs in S. pombe and C. albicans; also plays a role in formation of mature vacuoles	oligopeptide transport|vacuole fusion, non-autophagic	oligopeptide transporter activity	integral to membrane|integral to plasma membrane
YPR070W	YPR070W	MED1	hom	Verified	0.90846822719319	0.181815446544788	no	883	0.209912028059572	733	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS	RNA POL II, HOLOENZYME	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation	negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter	molecular_function	core mediator complex
YDR371W_p	YDR371W	CTS2	hom	Uncharacterized	0.908431557794485	0.181825129464197	no	884	0.166827154135591	557	NA	FT	CARBOHYDRATE METABOLISM			Putative chitinase, functionally complements A. gossypii cts2 mutant sporulation defect	sporulation resulting in formation of a cellular spore	molecular_function	cytoplasm
YMR142C	YMR142C	RPL13B	hom	Verified	0.908174190161854	0.181893099023714	no	885	0.196662464830527	678	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L13B; not essential for viability; homologous to mammalian ribosomal protein L13, no bacterial homolog; RPL13B has a paralog, RPL13A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YML005W	YML005W	TRM12	hom	Verified	0.907817984224082	0.18198719751931	no	886	0.204150647313742	674	NA	FT	RNA PROCESSING			S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; required for wybutosine formation in phenylalanine-accepting tRNA	wybutosine biosynthetic process|tRNA methylation	S-adenosylmethionine-dependent methyltransferase activity|transferase activity, transferring alkyl or aryl (other than methyl) groups	cytoplasm
YIL097W	YIL097W	FYV10	hom	Verified	0.907358638629947	0.182108587221415	no	887	0.188826398585455	670	NA	FT	KETONE METABOLISM|CARBOHYDRATE METABOLISM|PROTEOLYSIS	NUCLEUS		Subunit of GID complex; involved in proteasome-dependent catabolite inactivation of gluconeogenic enzymes FBPase, PEPCK, and c-MDH; forms dimer with Rmd5p that is then recruited to GID Complex by Gid8p; contains a degenerate RING finger motif needed for GID complex ubiquitin ligase activity in vivo, as well as CTLH and CRA domains; plays role in anti-apoptosis; required for survival upon exposure to K1 killer toxin	negative regulation of gluconeogenesis|proteasomal ubiquitin-dependent protein catabolic process|anti-apoptosis	ubiquitin-protein ligase activity	nucleus|GID complex|cytoplasm
YML016C	YML016C	PPZ1	hom	Verified	0.906939059163277	0.182219512286977	no	888	0.202542245442816	667	NA	FT	PROTEIN LOCALIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS	NUCLEUS|PLASMA MEMBRANE		Serine/threonine protein phosphatase Z, isoform of Ppz2p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance	cellular sodium ion homeostasis|cellular protein localization|protein dephosphorylation	protein serine/threonine phosphatase activity	extrinsic to plasma membrane|nucleus|cytoplasm
YMR261C	YMR261C	TPS3	hom	Verified	0.906361820561488	0.182372187008726	no	889	0.174609382881582	606	NA	FT	CARBOHYDRATE METABOLISM			Regulatory subunit of trehalose-6-phosphate synthase/phosphatase; involved in synthesis of storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway; TPS3 has a paralog, TSL1, that arose from the whole genome duplication	trehalose biosynthetic process|response to stress	enzyme regulator activity|alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity|trehalose-phosphatase activity	alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)
YDR417C_d	YDR417C	YDR417C	hom	Dubious	0.905805220806387	0.182519478594732	no	890	0.190465488596503	635	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RPL12B/YDR418W	Unknown	Unknown	Unknown
YDR150W	YDR150W	NUM1	hom	Verified	0.90529607101685	0.182654278666913	no	891	0.229142415460478	800	NA	FT	PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION	MITOCHONDRION|SITE OF POLARIZED GROWTH		Protein required for nuclear migration, localizes to the mother cell cortex and the bud tip; may mediate interactions of dynein and cytoplasmic microtubules with the cell cortex	mitochondrion inheritance|nuclear migration along microtubule|mitochondrial fission|microtubule cytoskeleton organization	tubulin binding	cell cortex|mitochondrion|cellular bud tip
YBR259W	YBR259W	YBR259W	hom	Verified	0.90458843127889	0.182841733203329	no	892	0.184765766455935	603	NA					Protein of unknown function; YBR259W is not an essential gene; forms cytoplasmic foci upon DNA replication stress	biological_process	molecular_function	cellular_component
YOR339C	YOR339C	UBC11	hom	Verified	0.904326952925949	0.182911029475188	no	893	0.172307907295931	560	NA					Ubiquitin-conjugating enzyme most similar in sequence to Xenopus ubiquitin-conjugating enzyme E2-C, but not a true functional homolog of this E2; unlike E2-C, not required for the degradation of mitotic cyclin Clb2	protein polyubiquitination|protein monoubiquitination	ubiquitin-protein ligase activity	cytoplasm
YCR066W	YCR066W	RAD18	hom	Verified	0.902560842789245	0.183379508227895	no	894	0.20860613210042	778	NA	FF|FT	RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		E3 ubiquitin ligase; forms heterodimer with Rad6p to monoubiquitinate PCNA-K164; heterodimer binds single-stranded DNA and has single-stranded DNA dependent ATPase activity; required for postreplication repair; SUMO-targeted ubiquitin ligase (STUbl) that contains a SUMO-interacting motif (SIM) which stimulates its ubiquitin ligase activity towards the sumoylated form of PCNA	protein monoubiquitination|error-free translesion synthesis|error-free postreplication DNA repair|error-prone translesion synthesis	ubiquitin-protein ligase activity|single-stranded DNA-dependent ATPase activity|single-stranded DNA binding	nuclear chromatin|nucleus
YDR048C_d	YDR048C	YDR048C	hom	Dubious	0.901182917716818	0.183745535953586	no	895	0.183780235009774	632	NA					Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDR142C	YDR142C	PEX7	hom	Verified	0.901073025690825	0.1837747469129	no	896	0.204649176704866	659	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|PEROXISOME ORGANIZATION			Peroxisomal signal receptor for the N-terminal nonapeptide signal (PTS2) of peroxisomal matrix proteins; WD repeat protein; defects in human homolog cause lethal rhizomelic chondrodysplasia punctata (RCDP)	protein import into peroxisome matrix, docking	peroxisome matrix targeting signal-2 binding	cytosol|peroxisome
YHR087W	YHR087W	RTC3	hom	Verified	0.900728967574634	0.183866221458967	no	897	0.211850938178103	761	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Protein of unknown function involved in RNA metabolism; has structural similarity to SBDS, the human protein mutated in Shwachman-Diamond Syndrome (the yeast SBDS ortholog = SDO1); null mutation suppresses cdc13-1 temperature sensitivity; protein abundance increases in response to DNA replication stress	RNA metabolic process	molecular_function	nucleus|cytoplasm
YOL093W	YOL093W	TRM10	hom	Verified	0.900695854526562	0.183875026702934	no	898	0.205725893485278	704	NA	FT	RNA PROCESSING	NUCLEUS		tRNA methyltransferase; methylates the N-1 position of guanosine in tRNAs; protein abundance increases in response to DNA replication stress	tRNA methylation	tRNA (guanine) methyltransferase activity	nucleus|cytoplasm
YAL009W	YAL009W	SPO7	hom	Verified	0.899664331790181	0.184149455197231	no	899	0.213251531951757	759	NA	FF|FT	CELL CYCLE|LIPID METABOLISM|MEMBRANE ORGANIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM		Putative regulatory subunit of Nem1p-Spo7p phosphatase holoenzyme, regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology, premeiotic replication, and sporulation	negative regulation of phospholipid biosynthetic process|nuclear envelope organization	phosphoprotein phosphatase activity	Nem1-Spo7 phosphatase complex|integral to membrane
YGR169C-A_p	YGR169C-A	YGR169C-A	hom	Uncharacterized	0.89940858453754	0.184217534157293	no	900	0.17992388566927	649	NA					Putative protein of unknown function; YGR169C-A has a paralog, YJR005C-A, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YNL136W	YNL136W	EAF7	hom	Verified	0.898155823917799	0.184551240575773	no	901	0.211454165100323	746	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE	NUCLEUS	HISTONE ACETYLTRANSFERASE	Subunit of the NuA4 histone acetyltransferase complex, which acetylates the N-terminal tails of histones H4 and H2A	DNA repair|histone acetylation|regulation of transcription from RNA polymerase II promoter	molecular_function	histone acetyltransferase complex|nucleus|NuA4 histone acetyltransferase complex
YOR044W	YOR044W	IRC23	hom	Verified	0.898139752734796	0.184555524007676	no	902	0.17510814389134	609	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Putative protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; null mutant displays increased levels of spontaneous Rad52p foci; IRC23 has a paralog, BSC2, that arose from the whole genome duplication	biological_process	molecular_function	endoplasmic reticulum
YOR198C	YOR198C	BFR1	hom	Verified	0.897754775771624	0.184658149905619	no	903	0.217156308213442	763	NA	FT	CELL CYCLE	ENDOMEMBRANE SYSTEM		Component of mRNP complexes associated with polyribosomes; implicated in secretion and nuclear segregation; multicopy suppressor of BFA (Brefeldin A) sensitivity	meiosis|mRNA metabolic process|regulation of mitosis	RNA binding	ribonucleoprotein complex|polysome|nuclear outer membrane-endoplasmic reticulum membrane network
YFR008W	YFR008W	FAR7	hom	Verified	0.897515080973969	0.1847220648798	no	904	0.189836094072499	686	NA	FT	CELL CYCLE|SIGNALING			Protein involved in recovery from pheromone-induced cell cycle arrest; acts in a Far1p-independent pathway; interacts with Far3p, Far8p, Far9p, Far10p, and Far11p; protein abundance increases in response to DNA replication stress	re-entry into mitotic cell cycle after pheromone arrest	molecular_function	cellular_component
YGL242C_p	YGL242C	YGL242C	hom	Uncharacterized	0.897429439393302	0.184744904669072	no	905	0.207492367743261	672	NA					Putative protein of unknown function; deletion mutant is viable	biological_process	molecular_function	cellular_component
YNL199C	YNL199C	GCR2	hom	Verified	0.896262230555962	0.185056363074198	no	906	0.203120771417662	726	NA	FT	TRANSCRIPTION FROM RNA POL II|RIBOSOME BIOGENESIS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	ENDOMEMBRANE SYSTEM|NUCLEUS		Transcriptional activator of genes involved in glycolysis; interacts and functions with the DNA-binding protein Gcr1p	positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter|regulation of glycolysis by positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II activating transcription factor binding|RNA polymerase II transcription factor binding transcription factor activity	nuclear envelope|nucleus
YNL089C_d	YNL089C	YNL089C	hom	Dubious	0.895270679738107	0.185321204932776	no	907	0.185644544902307	651	NA					Dubious open reading frame unlikely to encode a functional protein; almost completely overlaps YNL090W/RHO2 which encodes a small GTPase of the Rho/Rac subfamily of Ras-like proteins	Unknown	Unknown	Unknown
YOR216C	YOR216C	RUD3	hom	Verified	0.894916230203115	0.185415934985796	no	908	0.185056138060499	670	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	GOLGI APPARATUS		Golgi matrix protein involved in the structural organization of the cis-Golgi; interacts genetically with COG3 and USO1	ER to Golgi vesicle-mediated transport	molecular_function	Golgi apparatus
YPR188C	YPR188C	MLC2	hom	Verified	0.892905918278889	0.185953778742982	no	909	0.18032936216507	600	NA	FT	CELL CYCLE|CELL DIVISION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Regulatory light chain for the type II myosin, Myo1p; binds to an IQ motif of Myo1p, localization to the bud neck depends on Myo1p; involved in the disassembly of the Myo1p ring	actomyosin contractile ring contraction	myosin II binding	cellular bud neck contractile ring
YFR013W	YFR013W	IOC3	hom	Verified	0.890883762030596	0.186495766221998	no	910	0.227630533335059	794	NA	FT	CHROMATIN ORGANIZATION	NUCLEUS		Subunit of the Isw1a complex; Isw1a has nucleosome-stimulated ATPase activity and represses transcription initiation by specific positioning of a promoter proximal dinucleosome; IOC3 has a paralog, ESC8, that arose from the whole genome duplication	chromatin remodeling	nucleosome binding|ATPase activity|DNA binding	ISW1 complex
YOL033W	YOL033W	MSE1	hom	Verified	0.890814111587769	0.186514451661994	no	911	0.223922066552735	739	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial glutamyl-tRNA synthetase, predicted to be palmitoylated	mitochondrial glutamyl-tRNA aminoacylation|glutamyl-tRNA aminoacylation|mitochondrial translation	glutamate-tRNA(Gln) ligase activity|glutamate-tRNA ligase activity	mitochondrion
YDR462W	YDR462W	MRPL28	hom	Verified	0.890448160608177	0.186612646038131	no	912	0.191774877022226	681	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YJL057C	YJL057C	IKS1	hom	Verified	0.890320406276208	0.186646933457985	no	913	0.183867811786782	636	NA	FT	PROTEIN PHOSPHORYLATION			Protein kinase of unknown cellular role; putative serine/threonine kinase; expression is induced during mild heat stress; deletion mutants are hypersensitive to copper sulphate and resistant to sorbate; interacts with an N-terminal fragment of Sst2p	protein phosphorylation	protein kinase activity	cellular_component
YCR019W	YCR019W	MAK32	hom	Verified	0.888281416478172	0.187194696693838	no	914	0.183208747606249	643	NA					Protein necessary for structural stability of L-A double-stranded RNA-containing particles	interspecies interaction between organisms	molecular_function	cellular_component
YLR429W	YLR429W	CRN1	hom	Verified	0.887132199843996	0.187503864925591	no	915	0.168166978818622	589	NA	FT	CYTOSKELETON ORGANIZATION	CYTOSKELETON		Coronin, cortical actin cytoskeletal component that associates with the Arp2p/Arp3p complex to regulate its activity; plays a role in regulation of actin patch assembly	microtubule-based process|actin filament organization|actin cortical patch localization|Unknown|negative regulation of Arp2/3 complex-mediated actin nucleation	microtubule binding|actin filament binding|protein binding, bridging	Arp2/3 protein complex|actin cortical patch
YGR250C	YGR250C	YGR250C	hom	Verified	0.887062813476951	0.187522541702612	no	916	0.192778832541891	657	NA					Putative RNA binding protein; localizes to stress granules induced by glucose deprivation; interacts with Rbg1p in a two-hybrid assay; protein abundance increases in response to DNA replication stress	biological_process	RNA binding	cytoplasmic stress granule|cytoplasm
YPR065W	YPR065W	ROX1	hom	Verified	0.885873774549463	0.187842774771793	no	917	0.193007061857676	679	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS|CHROMOSOME		Heme-dependent repressor of hypoxic genes; mediates aerobic transcriptional repression of hypoxia induced genes such as COX5b and CYC7; repressor function regulated through decreased promoter occupancy in response to oxidative stress; contains an HMG domain that is responsible for DNA bending activity; involved in the hyperosmotic stress resistance	negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter in response to stress	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|DNA binding, bending|sequence-specific DNA binding|RNA polymerase II transcription factor recruiting transcription factor activity	nuclear chromatin
YMR032W	YMR032W	HOF1	hom	Verified	0.885451516635208	0.187956578877904	no	918	0.192163079469507	712	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CELL DIVISION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Bud neck-localized, SH3 domain-containing protein required for cytokinesis; is phosphorylated by Dbf2p; regulates actomyosin ring dynamics and septin localization; interacts with the formins, Bni1p and Bnr1p, and with Cyk3p, Vrp1p, and Bni5p	cytokinesis after mitosis|barrier septum assembly involved in cell cycle cytokinesis|response to DNA damage stimulus|cytokinesis	cytoskeletal protein binding	cellular bud neck contractile ring|cellular bud neck septin ring
YLL016W	YLL016W	SDC25	hom	pseudogene	0.884093276393309	0.188322931220268	no	919	0.182329135909312	626	NA	FT	SIGNALING			Non-essential Ras guanine nucleotide exchange factor (GEF); localized to the membrane; expressed in poor nutrient conditions and on nonfermentable carbon sources; contains a stop codon in S288C, full-length gene includes YLL017W; SDC25 has a paralog, CDC25, that arose from the whole genome duplication	Ras protein signal transduction	Ras guanyl-nucleotide exchange factor activity	cellular_component
YML026C	YML026C	RPS18B	hom	Verified	0.884055059798653	0.188333245586836	no	920	0.201044298268352	703	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION	MITOCHONDRION	RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S18 and bacterial S13; RPS18B has a paralog, RPS18A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress	cytoplasmic translation|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|rRNA export from nucleus	structural constituent of ribosome	cytosolic small ribosomal subunit|mitochondrion
YEL023C_p	YEL023C	YEL023C	hom	Uncharacterized	0.883480802286298	0.188488275255499	no	921	0.19102790649508	650	NA					Putative protein of unknown function; expression is increased greatly during sporulation; YEL023C is not an essential gene	biological_process	molecular_function	cellular_component
YML047W-A_d	YML047W-A	YML047W-A	hom	Dubious	0.883290638812903	0.188539630157243	no	922	0.183503891738866	608	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YBR071W	YBR071W	YBR071W	hom	Verified	0.881463549484606	0.18903348726336	no	923	0.1772930921145	577	NA	FT		SITE OF POLARIZED GROWTH		Protein of unknown function found in the cytoplasm and bud neck; mRNA expression may be regulated by the cell cycle and/or cell wall stress; overexpression of YBR071W affects endocytic protein trafficking	biological_process	molecular_function	cellular bud neck|cytoplasm
YNL228W_d	YNL228W	YNL228W	hom	Dubious	0.879725649174915	0.189503975501146	no	924	0.212271464143696	723	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps ORF YNL227C/JJJ1	Unknown	Unknown	Unknown
YDR165W	YDR165W	TRM82	hom	Verified	0.878728167731022	0.189774341076259	no	925	0.211921539494189	673	NA	FT	RNA PROCESSING	NUCLEUS		Catalytic subunit of a tRNA methyltransferase complex; Trm8p and Trm82p comprise an enzyme that catalyzes a methyl-transfer from S-adenosyl-l-methionine to the N(7) atom of guanine at position 46 in tRNA; Trm8 lacks catalytic activity if not bound to Trm82p	tRNA methylation	tRNA (guanine-N7-)-methyltransferase activity	tRNA methyltransferase complex|nucleus
YDL125C	YDL125C	HNT1	hom	Verified	0.878596011111627	0.189810179681201	no	926	0.185786671800154	635	NA	FT	NUCLEOTIDE METABOLISM	NUCLEUS		Adenosine 5'-monophosphoramidase; interacts physically and genetically with Kin28p, a CDK and TFIIK subunit, and genetically with CAK1; member of the histidine triad (HIT) superfamily of nucleotide-binding proteins and similar to Hint; protein abundance increases in response to DNA replication stress	nucleotide metabolic process	hydrolase activity|nucleotide binding	nucleus|cytoplasm
YLR021W	YLR021W	IRC25	hom	Verified	0.877972874024367	0.189979219824395	no	927	0.197965948323046	675	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS			Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions	proteasome assembly|chaperone-mediated protein complex assembly|nuclear-transcribed mRNA catabolic process, non-stop decay	molecular_function	intracellular
YGL149W_d	YGL149W	YGL149W	hom	Dubious	0.876997757050239	0.190243928174812	no	928	0.179878214679144	607	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF INO80/YGL150C.	Unknown	Unknown	Unknown
YPL221W	YPL221W	FLC1	hom	Verified	0.876799070839023	0.190297891939897	no	929	0.182263050830038	631	NA	FT	CELL WALL ORG/BIOGENESIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|SITE OF POLARIZED GROWTH		Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance	protein folding|fungal-type cell wall biogenesis|FAD transport	FAD transmembrane transporter activity	integral to membrane|endoplasmic reticulum|fungal-type vacuole|cellular bud neck
YOL067C	YOL067C	RTG1	hom	Verified	0.876522380312208	0.190373057571661	no	930	0.218951794577229	743	NA	FT	TRANSCRIPTION FROM RNA POL II|SIGNALING	NUCLEUS		Transcription factor (bHLH) involved in interorganelle communication between mitochondria, peroxisomes, and nucleus	cellular response to oleic acid|positive regulation of transcription from RNA polymerase II promoter|mitochondria-nucleus signaling pathway	sequence-specific DNA binding RNA polymerase II transcription factor activity	nucleus|cytoplasm
YHR182W	YHR182W	YHR182W	hom	Verified	0.875322691328504	0.190699175457954	no	931	0.21280692001268	689	NA	FT	SIGNALING			Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and cytoplasm; relocalizes from bud neck to cytoplasm upon DNA replication stress	biological_process	molecular_function	cytoplasm
YEL022W	YEL022W	GEA2	hom	Verified	0.87456390972748	0.19090561602538	no	932	0.226265807771848	779	NA	FT	VESICLE-MEDIATED TRANSPORT|SIGNALING|CYTOSKELETON ORGANIZATION|RESPONSE TO NUTRIENT LEVELS	GOLGI APPARATUS		Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs); involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; GEA2 has a paralog, GEA1, that arose from the whole genome duplication	retrograde vesicle-mediated transport, Golgi to ER|secretory granule organization|ER to Golgi vesicle-mediated transport|macroautophagy|intra-Golgi vesicle-mediated transport|actin cytoskeleton organization	ARF guanyl-nucleotide exchange factor activity	integral to membrane|Golgi cis cisterna|extrinsic to membrane
YKL139W	YKL139W	CTK1	hom	Verified	0.874084218448806	0.191036195612984	no	933	0.218147105397353	724	NA	FT	TRANSCRIPTION FROM RNA POL II|RNA PROCESSING|RESPONSE TO DNA DAMAGE|TRANSLATION|PROTEIN PHOSPHORYLATION	NUCLEUS		Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I); phosphorylates both RNA pol II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and ribosomal protein Rps2p to increase translational fidelity; similar to the Drosophila dCDK12 and human CDK12 and probably CDK13	mRNA 3'-end processing|phosphorylation of RNA polymerase II C-terminal domain|positive regulation of translational fidelity|positive regulation of transcription from RNA polymerase I promoter|peptidyl-serine phosphorylation|positive regulation of DNA-dependent transcription, elongation|protein phosphorylation	protein kinase activity|cyclin-dependent protein kinase activity	nucleoplasm|nucleolus|nucleus|polysome|carboxy-terminal domain protein kinase complex
YNL257C	YNL257C	SIP3	hom	Verified	0.871248075005979	0.191809357729717	no	934	0.223980420128259	767	NA	FT	TRANSCRIPTION FROM RNA POL II			Transcription cofactor; acts through interaction with DNA-bound Snf1p; C-terminal region has a putative leucine zipper motif; potential Cdc28p substrate; SIP3 has a paralog, YSP1, that arose from the whole genome duplication	positive regulation of transcription from RNA polymerase II promoter	transcription cofactor activity	integral to membrane
YIL045W	YIL045W	PIG2	hom	Verified	0.870146786686337	0.192110096020189	no	935	0.180563580344412	618	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY			Putative type-1 protein phosphatase targeting subunit that tethers Glc7p type-1 protein phosphatase to Gsy2p glycogen synthase	regulation of glycogen biosynthetic process	protein phosphatase type 1 regulator activity	cytoplasm
YLR052W	YLR052W	IES3	hom	Verified	0.869749708826302	0.19221860021898	no	936	0.19507318941336	641	NA	FT	CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS|CHROMOSOME		Subunit of the INO80 chromatin remodeling complex	nucleosome mobilization|telomere maintenance|chromatin silencing at telomere	molecular_function	nucleus|Ino80 complex
YDR143C	YDR143C	SAN1	hom	Verified	0.868781932660262	0.192483208553781	no	937	0.191706629926862	594	NA	FT	PROTEOLYSIS	NUCLEUS		Ubiquitin-protein ligase; involved in the proteasome-dependent degradation of aberrant nuclear proteins; targets substrates with regions of exposed hydrophobicity containing 5 or more contiguous hydrophobic residues; contains intrinsically disordered regions that contribute to substrate recognition	nucleus-associated proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to misfolded protein|response to stress	ubiquitin-protein ligase activity	nucleus|cytoplasm
YOR214C_p	YOR214C	YOR214C	hom	Uncharacterized	0.867672890294537	0.192786715416908	no	938	0.186142307267043	621	NA					Putative protein of unknown function; YOR214C is not an essential gene	biological_process	molecular_function	fungal-type cell wall
YIL130W	YIL130W	ASG1	hom	Verified	0.86762440413988	0.192799991081981	no	939	0.185172420481565	672	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Zinc cluster protein proposed to function as a transcriptional regulator involved in the stress response; null mutants have a respiratory deficiency, calcofluor white sensitivity and slightly increased cycloheximide resistance	biological_process	sequence-specific DNA binding	nucleus
YDR471W	YDR471W	RPL27B	hom	Verified	0.865499748310477	0.193382277008388	no	940	0.188989175020198	624	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L27B; homologous to mammalian ribosomal protein L27, no bacterial homolog; RPL27B has a paralog, RPL27A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YOR258W	YOR258W	HNT3	hom	Verified	0.863615429709573	0.193899592574006	no	941	0.226604065900856	788	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		DNA 5' AMP hydrolase involved in DNA repair; member of the histidine triad (HIT) superfamily of nucleotide-binding proteins; homolog of Aprataxin, a Hint related protein that is mutated in individuals with ataxia with oculomotor apraxia; relative distribution to nuclear foci decreases upon DNA replication stress	response to DNA damage stimulus	DNA 5'-adenosine monophosphate hydrolase activity	nucleus|cytoplasm
YGR102C	YGR102C	GTF1	hom	Verified	0.863418956608749	0.193953580262268	no	942	0.194996292678286	690	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION	MITOCHONDRION		Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is salt sensitive and null mutant has growth defects; non-tagged protein is detected in purified mitochondria	glutaminyl-tRNAGln biosynthesis via transamidation	glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity	mitochondrion|glutamyl-tRNA(Gln) amidotransferase complex
YDR213W	YDR213W	UPC2	hom	Verified	0.863091688466419	0.194043528685576	no	943	0.204006843494627	712	NA	FT	TRANSCRIPTION FROM RNA POL II|LIPID METABOLISM	NUCLEUS		Sterol regulatory element binding protein; induces transcription of sterol biosynthetic genes and of DAN/TIR gene products; relocates from intracellular membranes to perinuclear foci on sterol depletion; UPC2 has a paralog, ECM22, that arose from the whole genome duplication	cellular response to hypoxia|positive regulation of ergosterol biosynthetic process by positive regulation of transcription from RNA polymerase II promoter|positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus|membrane|cytoplasm|perinuclear region of cytoplasm
YNL293W	YNL293W	MSB3	hom	Verified	0.861944407322284	0.194359055276714	no	944	0.194202110028902	656	NA	FT	VESICLE-MEDIATED TRANSPORT|SIGNALING|NUCLEOTIDE METABOLISM|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH		Rab GTPase-activating protein; regulates endocytosis via activation of Vps21p and Ypt7p; also acts on Ypt52p and Sec4p; also required for proper actin organization; localizes to the plasma membrane and sites of polarized growth, and a portion localizes to endosomes and vacuoles; similar to Msb4p; relocalizes from bud neck to cytoplasm upon DNA replication stress	actin filament organization|exocytosis	Rab GTPase activator activity	incipient cellular bud site|polarisome|cellular bud tip
YDR195W	YDR195W	REF2	hom	Verified	0.861651511987239	0.194439657717453	no	945	0.219375834387215	735	NA	FT	TRANSCRIPTION FROM RNA POL II|RNA PROCESSING	NUCLEUS		RNA-binding protein involved in the cleavage step of mRNA 3'-end formation prior to polyadenylation, and in snoRNA maturation; part of holo-CPF subcomplex APT, which associates with 3'-ends of snoRNA- and mRNA-encoding genes	mRNA 3'-end processing|termination of RNA polymerase II transcription, poly(A)-coupled|snoRNA 3'-end processing|Unknown	chromatin binding|RNA binding	mRNA cleavage and polyadenylation specificity factor complex|nucleus
YOR183W_p	YOR183W	FYV12	hom	Uncharacterized	0.860970187856424	0.194627231341071	no	946	0.192877280696464	670	NA					Protein of unknown function, required for survival upon exposure to K1 killer toxin	biological_process	molecular_function	cellular_component
YMR223W	YMR223W	UBP8	hom	Verified	0.860244266571609	0.194827203999063	no	947	0.174851109744389	618	NA	FT	CHROMATIN ORGANIZATION|PROTEOLYSIS	NUCLEUS	HISTONE ACETYLTRANSFERASE	Ubiquitin-specific protease that is a component of the SAGA (Spt-Ada-Gcn5-Acetyltransferase) acetylation complex; required for SAGA-mediated deubiquitination of histone H2B	histone H3-K4 methylation|histone deubiquitination|histone H3-K79 methylation	ubiquitin-specific protease activity|protein complex scaffold	DUBm complex|SLIK (SAGA-like) complex|SAGA complex
YOR112W	YOR112W	CEX1	hom	Verified	0.860178251397328	0.194845395679862	no	948	0.197023454740103	658	NA	FT	RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS		Cytoplasmic component of the nuclear aminoacylation-dependent tRNA export pathway; interacts with nuclear pore component Nup116p; copurifies with tRNA export receptors Los1p and Msn5p, as well as eIF-1a and the RAN GTPase Gsp1p	tRNA export from nucleus	tRNA binding	nuclear pore|cytoplasm
YNR013C	YNR013C	PHO91	hom	Verified	0.860142009755563	0.194855383162017	no	949	0.209674407580423	690	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Low-affinity phosphate transporter of the vacuolar membrane; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth	phosphate ion transport|polyphosphate metabolic process	phosphate ion transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane|membrane
YER117W	YER117W	RPL23B	hom	Verified	0.859938179477949	0.194911560568672	no	950	0.190949767504345	679	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L23B; homologous to mammalian ribosomal protein L23 and bacterial L14; RPL23B has a paralog, RPL23A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YJL065C	YJL065C	DLS1	hom	Verified	0.859392495746023	0.195062004246369	no	951	0.224899525156364	760	NA	FT	GENE SILENCING	NUCLEUS		Subunit of ISW2/yCHRAC chromatin accessibility complex; ISW2/yCHRAC also includes Itc1p, Isw2p, and Dpb4p; involved in inheritance of telomeric silencing; DLS1 has a paralog, DPB3, that arose from the whole genome duplication	chromatin silencing at telomere	molecular_function	chromatin accessibility complex|nucleus
YLR206W	YLR206W	ENT2	hom	Verified	0.858636099663974	0.195270657507326	no	952	0.154016315403408	522	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Epsin-like protein required for endocytosis and actin patch assembly and functionally redundant with Ent1p; contains clathrin-binding motif at C-terminus	actin filament organization|endocytosis|actin cortical patch assembly	clathrin binding	mating projection tip|actin cortical patch
YPL181W	YPL181W	CTI6	hom	Verified	0.858524169859844	0.195301545065932	no	953	0.208756149505492	710	NA	FT	CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS|CHROMOSOME		Protein that relieves transcriptional repression by binding to the Cyc8p-Tup1p corepressor and recruiting the SAGA complex to the repressed promoter; contains a PHD finger domain	negative regulation of chromatin silencing at silent mating-type cassette|positive regulation of transcription, DNA-dependent|regulation of DNA-dependent DNA replication initiation|negative regulation of chromatin silencing at telomere|negative regulation of chromatin silencing at rDNA	methylated histone residue binding|transcription factor binding	Rpd3L-Expanded complex|nucleus|Rpd3L complex
YER058W	YER058W	PET117	hom	Verified	0.858347067477228	0.195350423369537	no	954	0.183950894631223	655	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Protein required for assembly of cytochrome c oxidase	mitochondrial respiratory chain complex IV assembly	molecular_function	mitochondrion
YKR080W	YKR080W	MTD1	hom	Verified	0.858067545455137	0.195427583482806	no	955	0.206540690444344	667	NA	FT	OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM	NUCLEUS		NAD-dependent 5,10-methylenetetrahydrafolate dehydrogenase, plays a catalytic role in oxidation of cytoplasmic one-carbon units; expression is regulated by Bas1p and Bas2p, repressed by adenine, and may be induced by inositol and choline	folic acid-containing compound biosynthetic process|one-carbon metabolic process|purine nucleobase biosynthetic process	methylenetetrahydrofolate dehydrogenase (NAD+) activity	cytosol
YGR241C	YGR241C	YAP1802	hom	Verified	0.85770777734746	0.195526922212699	no	956	0.208974372940571	728	NA	FT	VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON		Protein of the AP180 family, involved in clathrin cage assembly; binds Pan1p and clathrin; YAP1802 has a paralog, YAP1801, that arose from the whole genome duplication	endocytosis	clathrin binding	actin cortical patch
YOR032C	YOR032C	HMS1	hom	Verified	0.856704423851965	0.195804128921839	no	957	0.20922744387349	708	NA	FT		NUCLEUS		Basic helix-loop-helix (bHLH) protein with similarity to myc-family transcription factors; overexpression confers hyperfilamentous growth and suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant	pseudohyphal growth	sequence-specific DNA binding transcription factor activity	cellular_component
YAL054C	YAL054C	ACS1	hom	Verified	0.856549660003285	0.19584690833219	no	958	0.174351353400528	584	NA	FT	KETONE METABOLISM|CHROMATIN ORGANIZATION|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	NUCLEUS|ENDOPLASMIC RETICULUM|MITOCHONDRION		Acetyl-coA synthetase isoform which, along with Acs2p, is the nuclear source of acetyl-coA for histone acetylation; expressed during growth on nonfermentable carbon sources and under aerobic conditions	acetate fermentation|histone acetylation|acetyl-CoA biosynthetic process	acetate-CoA ligase activity|acid-ammonia (or amide) ligase activity	cytosol|mitochondrion|integral to membrane
YMR302C	YMR302C	YME2	hom	Verified	0.856427213315008	0.195880758737841	no	959	0.186709971242781	650	NA	FT	RNA PROCESSING|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Integral inner mitochondrial membrane protein with a role in maintaining mitochondrial nucleoid structure and number; mutants exhibit an increased rate of mitochondrial DNA escape; shows some sequence similarity to exonucleases	mitochondrial genome maintenance	molecular_function	mitochondrion|integral to mitochondrial inner membrane
YML027W	YML027W	YOX1	hom	Verified	0.853492047035038	0.19669324805859	no	960	0.183324238242689	627	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE	NUCLEUS|CHROMOSOME		Homeobox transcriptional repressor; binds to Mcm1p and to early cell cycle boxes (ECBs) in the promoters of cell cycle-regulated genes expressed in M/G1 phase; expression is cell cycle-regulated; potential Cdc28p substrate; relocalizes from nucleus to cytoplasm upon DNA replication stress; YOX1 has a paralog, YHP1, that arose from the whole genome duplication	negative regulation of transcription involved in G1 phase of mitotic cell cycle	RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription	nuclear chromatin|nucleus
YJL214W	YJL214W	HXT8	hom	Verified	0.853147258686949	0.196788823413734	no	961	0.193751198500343	653	NA	FT		PLASMA MEMBRANE		Protein of unknown function with similarity to hexose transporter family members, expression is induced by low levels of glucose and repressed by high levels of glucose	hexose transport	mannose transmembrane transporter activity|glucose transmembrane transporter activity|fructose transmembrane transporter activity	integral to membrane|plasma membrane
YPL135W	YPL135W	ISU1	hom	Verified	0.853087704724866	0.196805334624248	no	962	0.204077201896013	723	NA	FT	RNA PROCESSING|ION HOMEOSTASIS|ION HOMEOSTASIS|COFACTOR METABOLISM	MITOCHONDRION		Conserved protein of the mitochondrial matrix, performs a scaffolding function during assembly of iron-sulfur clusters, interacts physically and functionally with yeast frataxin (Yfh1p); isu1 isu2 double mutant is inviable	cellular iron ion homeostasis|iron-sulfur cluster assembly|tRNA wobble uridine modification	ferrous iron binding	mitochondrion|mitochondrial matrix
YOR354C	YOR354C	MSC6	hom	Verified	0.853065657454558	0.196811447396252	no	963	0.207429128962476	694	NA	FT	CELL CYCLE	MITOCHONDRION		Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	reciprocal meiotic recombination	molecular_function	mitochondrion
YGR110W	YGR110W	CLD1	hom	Verified	0.852820054336367	0.196879550487222	no	964	0.211007193178715	674	NA	FT	LIPID METABOLISM	MITOCHONDRION		Mitochondrial cardiolipin-specific phospholipase; functions upstream of Taz1p to generate monolyso-cardiolipin; transcription increases upon genotoxic stress; involved in restricting Ty1 transposition; has homology to mammalian CGI-58	cardiolipin acyl-chain remodeling|cardiolipin metabolic process	phospholipase A2 activity	mitochondrion
YEL033W_p	YEL033W	MTC7	hom	Uncharacterized	0.852535688954273	0.1969584197561	no	965	0.243005275117615	826	NA					Predicted metabolic role based on network analysis derived from ChIP experiments, a large-scale deletion study and localization of transcription factor binding sites; null mutant is sensitive to temperature oscillation in a cdc13-1 mutant	biological_process	molecular_function	cellular_component
YMR002W	YMR002W	MIC17	hom	Verified	0.8521711743163	0.197059546537269	no	966	0.205558843588088	701	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS|MITOCHONDRION		Mitochondrial intermembrane space protein; required for normal oxygen consumption; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress	aerobic respiration	molecular_function	nucleus|cytoplasm|mitochondrial intermembrane space
YMR246W	YMR246W	FAA4	hom	Verified	0.852033183571504	0.197097837312864	no	967	0.191329624755806	672	NA	FT	KETONE METABOLISM|LIPID METABOLISM|COFACTOR METABOLISM			Long chain fatty acyl-CoA synthetase; activates imported fatty acids with a preference for C12:0-C16:0 chain lengths; functions in long chain fatty acid import; important for survival during stationary phase; localized to lipid particles; involved in sphingolipid-to-glycerolipid metabolism; forms cytoplasmic foci upon DNA replication stress; FAA4 has a paralog, FAA1, that arose from the whole genome duplication	long-chain fatty acid transport|long-chain fatty-acyl-CoA metabolic process	long-chain fatty acid-CoA ligase activity	lipid particle|cytoplasm
YMR177W	YMR177W	MMT1	hom	Verified	0.851375202393937	0.197280481106125	no	968	0.199119494844421	707	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Putative metal transporter involved in mitochondrial iron accumulation; closely related to Mmt2p	cellular iron ion homeostasis	molecular_function	mitochondrion|integral to membrane
YPL056C_p	YPL056C	LCL1	hom	Uncharacterized	0.850846971293899	0.197427182663322	no	969	0.201652120426881	716	NA	FT		PLASMA MEMBRANE		Putative protein of unknown function; deletion mutant is fluconazole resistant and has long chronological lifespan	biological_process	molecular_function	cellular_component
YML036W	YML036W	CGI121	hom	Verified	0.850375050740049	0.197558301304541	no	970	0.220600275247005	738	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS|CHROMOSOME		Component of the EKC/KEOPS complex with Bud32p, Kae1p, Pcc1p, and Gon7p; EKC/KEOPS complex is required for t6A tRNA modification and may have roles in telomere maintenance and transcription; Cgi121p is dispensable for tRNA modification	telomere maintenance|positive regulation of transcription from RNA polymerase II promoter	molecular_function	EKC/KEOPS complex
YLR322W_d	YLR322W	VPS65	hom	Dubious	0.850285161305591	0.197583282197004	no	971	0.212395475640811	742	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 75% of ORF overlaps the verified gene SFH1; deletion causes a vacuolar protein sorting defect and blocks anaerobic growth	Unknown	Unknown	Unknown
YLR369W	YLR369W	SSQ1	hom	Verified	0.850060857046597	0.197645626221081	no	972	0.194403947788943	647	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|COFACTOR METABOLISM	MITOCHONDRION		Mitochondrial hsp70-type molecular chaperone, required for assembly of iron/sulfur clusters into proteins at a step after cluster synthesis, and for maturation of Yfh1p, which is a homolog of human frataxin implicated in Friedreich's ataxia	iron-sulfur cluster assembly|intracellular sequestering of iron ion|protein maturation	unfolded protein binding	mitochondrion|mitochondrial matrix
YDR278C_d	YDR278C	YDR278C	hom	Dubious	0.849992151966621	0.197664724764634	no	973	0.18252221470005	637	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YAL066W_d	YAL066W	YAL066W	hom	Dubious	0.84977549829663	0.197724957157551	no	974	0.22096679598227	682	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YAL058W	YAL058W	CNE1	hom	Verified	0.849416506423469	0.19782478573929	no	975	0.187725526714154	662	NA	FT	PROTEOLYSIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Calnexin; integral membrane ER chaperone involved in folding and quality control of glycoproteins; chaperone activity is inhibited by Mpd1p, with which Cne1p interacts; 24% identical to mammalian calnexin; Ca+ binding not yet shown in yeast	protein folding|ER-associated protein catabolic process	unfolded protein binding	integral to endoplasmic reticulum membrane
YBL055C	YBL055C	YBL055C	hom	Verified	0.848842837660721	0.197984374941015	no	976	0.176588651167328	609	NA	FT	RESPONSE TO OXIDATIVE STRESS			3'-->5' exonuclease and endonuclease with a possible role in apoptosis; has similarity to mammalian and C. elegans apoptotic nucleases	cellular response to oxidative stress|apoptotic DNA fragmentation	3'-5'-exodeoxyribonuclease activity|endonuclease activity	cytoplasm
YPL018W	YPL018W	CTF19	hom	Verified	0.848716873619295	0.19801942734946	no	977	0.2247012385064	771	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME	KINETOCHORE	Outer kinetochore protein, needed for accurate chromosome segregation; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) that functions as a platform for kinetochore assembly; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-P and fission yeast fta2	attachment of spindle microtubules to kinetochore|chromosome segregation|establishment of mitotic sister chromatid cohesion	molecular_function	COMA complex|condensed nuclear chromosome kinetochore|nucleus
YKR069W	YKR069W	MET1	hom	Verified	0.848512949484426	0.198076181901712	no	978	0.19877414064685	680	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM			S-adenosyl-L-methionine uroporphyrinogen III transmethylase, involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis	siroheme biosynthetic process|methionine biosynthetic process|sulfate assimilation	uroporphyrin-III C-methyltransferase activity	intracellular
YER185W	YER185W	PUG1	hom	Verified	0.848034769589625	0.198209303662543	no	979	0.189936163207545	656	NA	FT		PLASMA MEMBRANE		Plasma membrane protein with roles in the uptake of protoprophyrin IX and the efflux of heme; expression is induced under both low-heme and low-oxygen conditions; member of the fungal lipid-translocating exporter (LTE) family of proteins	heme transport	molecular_function	integral to membrane|plasma membrane
YMR251W	YMR251W	GTO3	hom	Verified	0.847000327166846	0.198497469545097	no	980	0.210304068575354	712	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Omega class glutathione transferase; putative cytosolic localization	glutathione metabolic process	glutathione transferase activity	cytoplasm
YOR280C	YOR280C	FSH3	hom	Verified	0.846999968418681	0.19849756952583	no	981	0.19489948826496	654	NA					Putative serine hydrolase; likely target of Cyc8p-Tup1p-Rfx1p transcriptional regulation; sequence is similar to S. cerevisiae Fsh1p and Fsh2p and the human candidate tumor suppressor OVCA2	biological_process	molecular_function	cellular_component
YPL027W	YPL027W	SMA1	hom	Verified	0.846775646690784	0.198560092451084	no	982	0.169367297176999	557	NA	FT	MEMBRANE ORGANIZATION			Protein of unknown function involved in the assembly of the prospore membrane during sporulation; interacts with Spo14p	ascospore-type prospore membrane assembly	molecular_function	prospore membrane
YBR131W	YBR131W	CCZ1	hom	Verified	0.846718446884953	0.198576037074618	no	983	0.196341843386666	687	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS			Protein involved in vacuolar assembly, essential for autophagy and the cytoplasm-to-vacuole pathway	autophagy|autophagic vacuole fusion|vacuolar transport|vesicle docking|protein targeting to vacuole	guanyl-nucleotide exchange factor activity	Mon1-Ccz1 complex|membrane
YNR075W	YNR075W	COS10	hom	Verified	0.843904435762164	0.199361404641709	no	984	0.175995686523354	647	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM		Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins	endocytosis	molecular_function	nuclear envelope|integral to membrane|endoplasmic reticulum|cytoplasm
YLR080W	YLR080W	EMP46	hom	Verified	0.843770637721493	0.199398793100796	no	985	0.173214968998386	579	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport	ER to Golgi vesicle-mediated transport	glycoprotein binding	ER to Golgi transport vesicle|Golgi membrane
YIL074C	YIL074C	SER33	hom	Verified	0.843554411419203	0.199459224195991	no	986	0.194999530978698	700	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS			3-phosphoglycerate dehydrogenase; catalyzes the first step in serine and glycine biosynthesis; SER33 has a paralog, SER3, that arose from the whole genome duplication	serine family amino acid biosynthetic process	phosphoglycerate dehydrogenase activity	cytoplasm
YCR051W_p	YCR051W	YCR051W	hom	Uncharacterized	0.843241456603126	0.199546708574894	no	987	0.196343759374656	691	NA	FT		NUCLEUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; contains ankyrin (Ank) repeats; YCR051W is not an essential gene	biological_process	molecular_function	nucleus|cytoplasm
YDR070C	YDR070C	FMP16	hom	Verified	0.842761421971303	0.199680943844214	no	988	0.183144609583505	661	NA	FT		MITOCHONDRION		Protein of unknown function; may be involved in responding to conditions of stress; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	mitochondrion
YNR032C-A	YNR032C-A	HUB1	hom	Verified	0.842235033368929	0.199828203818803	no	989	0.174436976511743	641	NA	FT	RNA PROCESSING			Ubiquitin-like protein modifier; promotes alternative splicing of SRC1 pre-mRNA; binds non-covalently to the HIND domain of Snu66, may function in modification of Sph1p and Hbt1p, functionally complemented by the human or S. pombe ortholog; mechanism of Hub1p adduct formation not yet clear	cellular protein modification process|cell morphogenesis involved in conjugation with cellular fusion|mRNA splicing, via spliceosome	protein tag	mating projection
YOR127W	YOR127W	RGA1	hom	Verified	0.841874849871987	0.199929004671832	no	990	0.205618084734019	705	NA	FT	SIGNALING|CELL DIVISION|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		GTPase-activating protein for polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth; relocalizes from bud neck to cytoplasm upon DNA replication stress	budding cell isotropic bud growth|pheromone-dependent signal transduction involved in conjugation with cellular fusion|pseudohyphal growth|actin filament organization|establishment of cell polarity|small GTPase mediated signal transduction|invasive growth in response to glucose limitation|budding cell apical bud growth	Rho GTPase activator activity	cellular bud neck split septin rings
YNR045W	YNR045W	PET494	hom	Verified	0.841871002876266	0.199930081455988	no	991	0.176787322250617	606	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet122p; located in the mitochondrial inner membrane	mitochondrial respiratory chain complex IV biogenesis|positive regulation of mitochondrial translation	translation regulator activity	mitochondrion|mitochondrial inner membrane
YLR408C_p	YLR408C	BLS1	hom	Uncharacterized	0.841599971771041	0.200005952548142	no	992	0.178454483186738	592	NA					Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to the endosome; YLR408C is not an essential gene	biological_process	molecular_function	endosome|BLOC-1 complex
YBR245C	YBR245C	ISW1	hom	Verified	0.840542898270982	0.200302029796275	no	993	0.188721486467292	679	NA	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS|CHROMOSOME		ATPase subunit of imitation-switch (ISWI) class chromatin remodelers; ATPase; forms a complex with Ioc3p (Isw1a), and a complex with Ioc2p and Ioc4p (Isw1b); Isw1a and Isw1b have partially overlapping and distinct roles, Isw1a involved in repression of transcription initiation and Isw1b involved in regulation of transcription elongation; Isw1b recruited to open reading frames by H3K36 methylation and acts with Chd1p to prevent trans-histone exchange over coding regions	termination of RNA polymerase I transcription|nucleosome positioning|termination of RNA polymerase II transcription|regulation of transcription by chromatin organization|DNA-dependent transcription, elongation|regulation of transcriptional start site selection at RNA polymerase II promoter|heterochromatin maintenance involved in chromatin silencing|chromatin remodeling|positive regulation of transcription from RNA polymerase II promoter	nucleosome binding|ATPase activity|rDNA binding|DNA binding	ISW1 complex|nucleolar chromatin
YLR262C	YLR262C	YPT6	hom	Verified	0.840058040513719	0.200437922358299	no	994	0.303130592213239	1031	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING	GOLGI APPARATUS|PLASMA MEMBRANE		Rab family GTPase, Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity to the human GTPase, Rab6	intracellular protein transport|retrograde transport, endosome to Golgi	GTPase activity	Golgi apparatus
YKR057W	YKR057W	RPS21A	hom	Verified	0.838277244715163	0.200937506423546	no	995	0.202179296979105	713	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21A has a paralog, RPS21B, that arose from the whole genome duplication	cytoplasmic translation|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome	cytosolic small ribosomal subunit
YBL039C	YBL039C	URA7	hom	Verified	0.83725719864229	0.201224006146672	no	996	0.202844147039667	711	NA	FT	KETONE METABOLISM|LIPID METABOLISM|AMINO ACID METABOLISM|NUCLEOTIDE METABOLISM			Major CTP synthase isozyme (see also URA8); catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis; capable of forming cytoplasmic filaments termed cytoophidium, especially during conditions of glucose depletion; URA7 has a paralog, URA8, that arose from the whole genome duplication	pyrimidine nucleobase biosynthetic process|CTP biosynthetic process|phospholipid biosynthetic process	CTP synthase activity	cytosol
YAL008W	YAL008W	FUN14	hom	Verified	0.836654624530143	0.201393365791352	no	997	0.221116982020045	701	NA	FT		MITOCHONDRION		Mitochondrial protein of unknown function	biological_process	molecular_function	mitochondrial outer membrane|mitochondrion
YDR031W	YDR031W	MIC14	hom	Verified	0.835072636458197	0.201838406180164	no	998	0.182048534605696	551	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS|MITOCHONDRION		Mitochondrial intermembrane space protein of unknown function; required for normal oxygen consumption; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress	aerobic respiration	molecular_function	nucleus|mitochondrial intermembrane space|cytoplasm
YPL271W	YPL271W	ATP15	hom	Verified	0.834827588322918	0.201907395056751	no	999	0.234804577169018	756	NA	FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS	MITOCHONDRION		Epsilon subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated	ATP synthesis coupled proton transport	hydrogen ion transporting ATP synthase activity, rotational mechanism|ATPase activity|proton-transporting ATPase activity, rotational mechanism	proton-transporting ATP synthase complex, catalytic core F(1)|mitochondrion|integral to membrane|mitochondrial proton-transporting ATP synthase, central stalk
YCR034W	YCR034W	FEN1	hom	Verified	0.834080239756054	0.20211788470838	no	1000	0.303315702183629	1037	NA	FF|FT	VESICLE-MEDIATED TRANSPORT|KETONE METABOLISM|LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Fatty acid elongase, involved in sphingolipid biosynthesis; acts on fatty acids of up to 24 carbons in length; mutations have regulatory effects on 1,3-beta-glucan synthase, vacuolar ATPase, and the secretory pathway; FEN1 has a paralog, ELO1, that arose from the whole genome duplication	fatty acid elongation|vesicle-mediated transport|sphingolipid biosynthetic process	fatty acid elongase activity	integral to membrane|endoplasmic reticulum|endoplasmic reticulum membrane
YDR120C	YDR120C	TRM1	hom	Verified	0.833899091594775	0.202168924591659	no	1001	0.213366766493433	744	NA	FT	RNA PROCESSING	ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION		tRNA methyltransferase; two forms of the protein are made by alternative translation starts; localizes to both the nucleus and mitochondrion to produce the modified base N2,N2-dimethylguanosine in tRNAs in both compartments	tRNA methylation	tRNA (guanine-N2-)-methyltransferase activity	mitochondrion|nuclear envelope|nuclear inner membrane
YHR078W_p	YHR078W	YHR078W	hom	Uncharacterized	0.833856228006048	0.202181002864541	no	1002	0.189391430961341	631	NA					High osmolarity-regulated gene of unknown function	biological_process	molecular_function	integral to membrane
YER139C	YER139C	RTR1	hom	Verified	0.833418516471767	0.202304367677676	no	1003	0.192392731460067	697	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		CTD phosphatase; dephosphorylates S5-P in the C-terminal domain of Rpo21p; has a cysteine-rich motif required for function and conserved in eukaryotes; shuttles between the nucleus and cytoplasm; RTR1 has a paralog, RTR2, that arose from the whole genome duplication	dephosphorylation of RNA polymerase II C-terminal domain|transcription from RNA polymerase II promoter	CTD phosphatase activity	nucleus|cytoplasm
YOR129C	YOR129C	AFI1	hom	Verified	0.832793832305272	0.202480506897016	no	1004	0.187945402791549	646	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|CELL DIVISION	NUCLEUS|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Arf3p polarization-specific docking factor, required for the polarized distribution of the ADP-ribosylation factor, Arf3p; participates in polarity development and maintenance of a normal haploid budding pattern; interacts with Cnm7p	asymmetric protein localization|actin cortical patch localization|cellular bud site selection	molecular_function	nucleus|plasma membrane|cellular bud neck|cytoplasm
YKL215C	YKL215C	OXP1	hom	Verified	0.832583505876666	0.202539832264825	no	1005	0.170946990116209	553	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			5-oxoprolinase; enzyme is ATP-dependent and functions as a dimer; similar to mouse Oplah gene; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress	glutathione metabolic process	5-oxoprolinase (ATP-hydrolyzing) activity	cytoplasm
YJR080C	YJR080C	AIM24	hom	Verified	0.830704292873228	0.203070350317342	no	1006	0.169032143930521	603	NA	FT		MITOCHONDRION		Protein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays reduced respiratory growth and elevated frequency of mitochondrial genome loss	biological_process	molecular_function	mitochondrion
YNL057W_d	YNL057W	YNL057W	hom	Dubious	0.830392444032524	0.203158468134893	no	1007	0.193185884020375	661	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YMR320W_d	YMR320W	YMR320W	hom	Dubious	0.830353576209776	0.203169452451896	no	1008	0.190465143014592	682	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YKL207W	YKL207W	EMC3	hom	Verified	0.830218489854258	0.203207631552553	no	1009	0.186520256419395	674	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; required for respiratory growth; null mutant displays induction of the unfolded protein response; homologous to worm Y62E10A.10/EMC-3, fly CG6750, human TMEM111	protein folding in endoplasmic reticulum	molecular_function	ER membrane protein complex|integral to membrane
YMR310C_p	YMR310C	YMR310C	hom	Uncharacterized	0.830207034917437	0.20321086922811	no	1010	0.207854585790864	695	NA	FT		NUCLEUS		Putative S-adenosylmethionine-dependent methyltransferase; predicted to be involved in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR310C is not an essential gene	biological_process	S-adenosylmethionine-dependent methyltransferase activity	nucleus
YER068W	YER068W	MOT2	hom	Verified	0.828906088856178	0.203578774840915	no	1011	0.219404205183499	742	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Ubiquitin-protein ligase subunit of the CCR4-NOT complex; with Ubc4p, ubiquitinates nascent polypeptide-associated complex subunits and histone demethyase Jhd2p; CCR4-NOT has roles in transcription regulation, mRNA degradation, and post-transcriptional modifications	deadenylation-independent decapping of nuclear-transcribed mRNA|positive regulation of transcription elongation from RNA polymerase II promoter|protein polyubiquitination|protein ubiquitination	ubiquitin-protein ligase activity|sequence-specific DNA binding	CCR4-NOT core complex|cytoplasm
YLR164W	YLR164W	SHH4	hom	Verified	0.828013301401827	0.203831483495598	no	1012	0.172471186467675	597	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Mitochondrial inner membrane protein of unknown function; similar to Tim18p and Sdh4p; a fraction copurifies with Sdh3p, but Shh4p is neither a stoichiometric subunit of succinate dehydrogenase nor of the TIM22 translocase; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner	biological_process	molecular_function	mitochondrion|mitochondrial inner membrane
YLR070C	YLR070C	XYL2	hom	Verified	0.827865087680036	0.20387345433637	no	1013	0.209248022433548	692	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM			Xylitol dehydrogenase, converts xylitol to D-xylulose; expression induced by xylose, even though this pentose sugar is not well utilized by S. cerevisiae; null mutant has cell wall defect	xylulose biosynthetic process	D-xylulose reductase activity	cellular_component
YKR094C	YKR094C	RPL40B	hom	Verified	0.826478618065033	0.20426632118792	no	1014	0.19740461129726	700	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RESPONSE TO DNA DAMAGE|TRANSLATION	NUCLEUS|MITOCHONDRION	RIBOSOME	Ubiquitin-ribosomal 60S subunit protein L40B fusion protein; cleaved to yield ubiquitin and ribosomal protein L40B; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; homologous to mammalian ribosomal protein L40, no bacterial homolog; RPL40B has a paralog, RPL40A, that arose from the whole genome duplication	cytoplasmic translation|protein ubiquitination|ribosome biogenesis	structural constituent of ribosome|protein tag	mitochondrion|cytosolic large ribosomal subunit
YJR109C	YJR109C	CPA2	hom	Verified	0.825252991584221	0.204613986993046	no	1015	0.179032537089731	601	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Large subunit of carbamoyl phosphate synthetase, which catalyzes a step in the synthesis of citrulline, an arginine precursor	arginine biosynthetic process	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity	carbamoyl-phosphate synthase complex
YGR058W	YGR058W	PEF1	hom	Verified	0.82476732643953	0.204751849927937	no	1016	0.189751712463417	669	NA	FT	CELL CYCLE|CELL DIVISION	NUCLEUS|SITE OF POLARIZED GROWTH		Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly	bipolar cellular bud site selection|regulation of COPII vesicle coating|axial cellular bud site selection	zinc ion binding|calcium ion binding	cytosol|site of polarized growth|nucleus|cellular bud neck|cytoplasm
YDR019C	YDR019C	GCV1	hom	Verified	0.824730079479986	0.204762425285895	no	1017	0.219060118823812	777	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		T subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of levels of 5,10-methylene-THF in the cytoplasm	glycine catabolic process|glycine metabolic process|one-carbon metabolic process	glycine dehydrogenase (decarboxylating) activity	mitochondrion|glycine cleavage complex
YHR193C	YHR193C	EGD2	hom	Verified	0.824574136070793	0.20480670510829	no	1018	0.205710150104517	703	NA	FT	PROTEIN LOCALIZATION	NUCLEUS		Alpha subunit of the heteromeric nascent polypeptide-associated complex (NAC) involved in protein sorting and translocation, associated with cytoplasmic ribosomes	'de novo' cotranslational protein folding	unfolded protein binding|phosphatidic acid binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4-phosphate binding	nascent polypeptide-associated complex
YBL031W	YBL031W	SHE1	hom	Verified	0.822329756359362	0.205444622828322	no	1019	0.203973280913307	722	NA	FT	CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION	NUCLEUS|SITE OF POLARIZED GROWTH|CYTOSKELETON		Mitotic spindle protein; interacts with components of the Dam1 (DASH) complex, its effector Sli15p, and microtubule-associated protein Bim1p; also localizes to nuclear microtubules and to the bud neck in a ring-shaped structure; inhibits dynein function	mitotic spindle elongation	molecular_function	microtubule cytoskeleton|nuclear microtubule|cellular bud neck|astral microtubule|spindle
YGR252W	YGR252W	GCN5	hom	Verified	0.82013316962428	0.206070097473583	no	1020	0.276112071671866	973	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION	NUCLEUS|CHROMOSOME	HISTONE ACETYLTRANSFERASE	Acetyltransferase, modifies N-terminal lysines on histones H2B and H3; acetylates Rsc4p, a subunit of the RSC chromatin-remodeling complex, altering replication stress tolerance; catalytic subunit of the ADA and SAGA histone acetyltransferase complexes; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay; greater involvement in repression of RNAPII-dependent transcription than in activation	histone acetylation|regulation of transcription by chromatin organization|chromatin modification|positive regulation of transcription elongation from RNA polymerase II promoter	histone acetyl-lysine binding|transcription coactivator activity|histone acetyltransferase activity|H3 histone acetyltransferase activity	SLIK (SAGA-like) complex|chromosome, centromeric region|Ada2/Gcn5/Ada3 transcription activator complex|SAGA complex
YMR087W	YMR087W	YMR087W	hom	Verified	0.819971304247178	0.206116233014933	no	1021	0.205154151099653	723	NA	FT	RNA PROCESSING			Putative ADP-ribose-1''-monophosphatase that converts ADP-ribose-1''-monophosphate to ADP-ribose; may have a role in tRNA splicing; contains an A1pp domain	tRNA splicing, via endonucleolytic cleavage and ligation	phosphatase activity	cellular_component
YKL068W-A_p	YKL068W-A	YKL068W-A	hom	Uncharacterized	0.819913671970986	0.206132661083768	no	1022	0.254025916313064	896	NA					Putative protein of unknown function; identified by homology to <i>Ashbya gossypii</i>	biological_process	molecular_function	cellular_component
YHR049W	YHR049W	FSH1	hom	Verified	0.819811980986031	0.206161649972087	no	1023	0.173724321677954	618	NA	FT		NUCLEUS		Putative serine hydrolase that localizes to both the nucleus and cytoplasm; sequence is similar to S. cerevisiae Fsh2p and Fsh3p and the human candidate tumor suppressor OVCA2	biological_process	hydrolase activity	nucleus|cytoplasm
YHR033W_p	YHR033W	YHR033W	hom	Uncharacterized	0.819319889997023	0.206301963715351	no	1024	0.17150233622409	542	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm; YHR033W has a paralog, PRO1, that arose from the whole genome duplication	biological_process	molecular_function	cytoplasm
YHR185C	YHR185C	PFS1	hom	Verified	0.817823468872414	0.206728997554274	no	1025	0.216781106014618	752	NA	FT	CELL WALL ORG/BIOGENESIS	NUCLEUS|CYTOSKELETON		Sporulation protein required for prospore membrane formation at selected spindle poles, ensures functionality of all four spindle pole bodies during meiosis II; not required for meiotic recombination or meiotic chromosome segregation	ascospore wall assembly	molecular_function	cellular_component
YGL021W	YGL021W	ALK1	hom	Verified	0.817039286484561	0.206952988596401	no	1026	0.210608280470686	696	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION			Protein kinase; accumulation and phosphorylation are periodic during the cell cycle; phosphorylated in response to DNA damage; contains characteristic motifs for degradation via the APC pathway; ALK1 has a paralog, ALK2, that arose from the whole genome duplication; similar to mammalian haspins	mitosis|protein phosphorylation	protein serine/threonine kinase activity|protein kinase activity	cellular_component
YHR031C	YHR031C	RRM3	hom	Verified	0.81691868909674	0.206987448338863	no	1027	0.227785389020253	776	NA	FT	RESPONSE TO DNA DAMAGE|MITOCHONDRION ORGANIZATION	NUCLEUS|CHROMOSOME		DNA helicase involved in rDNA replication and Ty1 transposition; relieves replication fork pauses at telomeric regions; structurally and functionally related to Pif1p	mitochondrial genome maintenance|replication fork progression beyond termination site|DNA replication	ATP-dependent DNA helicase activity|DNA helicase activity	nuclear telomeric heterochromatin|replication fork
YLR258W	YLR258W	GSY2	hom	Verified	0.816902791080511	0.206991991323586	no	1028	0.203782503913736	696	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY			Glycogen synthase; expression induced by glucose limitation, nitrogen starvation, heat shock, and stationary phase; activity regulated by cAMP-dependent, Snf1p and Pho85p kinases as well as by the Gac1p-Glc7p phosphatase; GSY2 has a paralog, GSY1, that arose from the whole genome duplication; relocalizes from cytoplasm to plasma membrane upon DNA replication stress	glycogen biosynthetic process	glycogen (starch) synthase activity	cytoplasm
YPR002W	YPR002W	PDH1	hom	Verified	0.816705078580044	0.207048494174184	no	1029	0.21525673504406	760	NA	FT	KETONE METABOLISM	MITOCHONDRION		Mitochondrial protein that participates in respiration, induced by diauxic shift; homologous to E. coli PrpD, may take part in the conversion of 2-methylcitrate to 2-methylisocitrate	propionate metabolic process|propionate catabolic process, 2-methylcitrate cycle	2-methylcitrate dehydratase activity	mitochondrial outer membrane|mitochondrion|cytoplasm
YKR006C	YKR006C	MRPL13	hom	Verified	0.816001544533445	0.207249626165684	no	1030	0.205857654849623	743	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit, not essential for mitochondrial translation	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YPL097W	YPL097W	MSY1	hom	Verified	0.815975510880305	0.207257071092832	no	1031	0.219292326920885	744	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial tyrosyl-tRNA synthetase	mitochondrial tyrosyl-tRNA aminoacylation	tyrosine-tRNA ligase activity	mitochondrion
YLR013W	YLR013W	GAT3	hom	Verified	0.815691339346852	0.207338346820862	no	1032	0.200874774632127	667	NA	FT		NUCLEUS		Protein containing GATA family zinc finger motifs	transcription, DNA-dependent	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	nucleus
YMR196W_p	YMR196W	YMR196W	hom	Uncharacterized	0.815532887141119	0.207383673822318	no	1033	0.227331093473022	789	NA	FT	CARBOHYDRATE METABOLISM			Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR196W is not an essential gene	biological_process	molecular_function	cytoplasm
YHR206W	YHR206W	SKN7	hom	Verified	0.815333322885244	0.207440769713792	no	1034	0.241114594043974	828	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|SIGNALING|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		Nuclear response regulator and transcription factor; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; part of a branched two-component signaling system; required for optimal induction of heat-shock genes in response to oxidative stress; involved in osmoregulation; SKN7 has a paralog, HMS2, that arose from the whole genome duplication	response to singlet oxygen|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|transcription, DNA-dependent|response to osmotic stress|regulation of cell size	sequence-specific DNA binding|two-component response regulator activity|sequence-specific DNA binding transcription factor activity	nucleus
YBR031W	YBR031W	RPL4A	hom	Verified	0.813567681458635	0.207946329311821	no	1035	0.198740479162485	716	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L4A; N-terminally acetylated; homologous to mammalian ribosomal protein L4 and bacterial L4; RPL4A has a paralog, RPL4B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YCL051W	YCL051W	LRE1	hom	Verified	0.812615786138184	0.208219188929358	no	1036	0.223419526571343	781	NA	FT	CELL WALL ORG/BIOGENESIS			Protein involved in control of cell wall structure and stress response; overproduction confers resistance to cell-wall degrading enzymes; exhibits genetic interactions with genes involved in the cell wall integrity pathway; <br>LRE1 has a paralog, HLR1, that arose from the whole genome duplication	fungal-type cell wall organization	molecular_function	cellular_component
YDR450W	YDR450W	RPS18A	hom	Verified	0.81150445080124	0.208538018981462	no	1037	0.221680143661205	747	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION	MITOCHONDRION	RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S18 and bacterial S13; RPS18A has a paralog, RPS18B, that arose from the whole genome duplication; protein increases in abundance and relocalizes from cytoplasm to nuclear foci upon DNA replication stress	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|cytoplasmic translation|rRNA export from nucleus	structural constituent of ribosome	cytosolic small ribosomal subunit|mitochondrion
YMR163C	YMR163C	INP2	hom	Verified	0.810628339819806	0.208789568504563	no	1038	0.196406224874681	658	NA	FT	PEROXISOME ORGANIZATION			Peroxisome-specific receptor important for peroxisome inheritance; co-fractionates with peroxisome membranes and co-localizes with peroxisomes in vivo; physically interacts with the myosin V motor Myo2p; INP2 is not an essential gene	peroxisome inheritance	protein anchor	peroxisome|integral to peroxisomal membrane|cytoplasm
YMR035W	YMR035W	IMP2	hom	Verified	0.809372540362709	0.209150446072597	no	1039	0.1767151206965	607	NA	FT	PROTEIN LOCALIZATION|PROTEOLYSIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p	protein processing involved in protein targeting to mitochondrion	endopeptidase activity	mitochondrial inner membrane peptidase complex
YJL158C	YJL158C	CIS3	hom	Verified	0.807110814660623	0.209801320983199	no	1040	0.191820407234466	639	NA	FT	CELL WALL ORG/BIOGENESIS	ENDOPLASMIC RETICULUM|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Mannose-containing glycoprotein constituent of the cell wall; member of the PIR (proteins with internal repeats) family	fungal-type cell wall organization	structural constituent of cell wall	extracellular region|fungal-type cell wall|endoplasmic reticulum|plasma membrane|cellular bud tip
YGR266W	YGR266W	YGR266W	hom	Verified	0.806757700088135	0.209903046949129	no	1041	0.201561991395512	673	NA	FT		MITOCHONDRION|PLASMA MEMBRANE		Protein of unknown function; predicted to contain a single transmembrane domain; mutant has increased aneuploidy tolerance; localized to both the mitochondrial outer membrane and the plasma membrane; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	mitochondrial outer membrane|mitochondrion|plasma membrane
YHR130C_d	YHR130C	YHR130C	hom	Dubious	0.806383369981437	0.210010916377282	no	1042	0.2155845905429	726	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YGL163C	YGL163C	RAD54	hom	Verified	0.806138701753255	0.210081439184144	no	1043	0.278961850288299	927	NA	FF|FT	CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE	NUCLEUS		DNA-dependent ATPase that stimulates strand exchange; modifies the topology of double-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; member of the SWI/SNF family; forms nuclear foci upon DNA replication stress	positive regulation of endodeoxyribonuclease activity|DNA geometric change|heteroduplex formation|telomere maintenance via recombination|double-strand break repair via synthesis-dependent strand annealing|chromatin remodeling|double-strand break repair via single-strand annealing	DNA-dependent ATPase activity|DNA translocase activity	nucleus
YIL154C	YIL154C	IMP2'	hom	Verified	0.806052526116902	0.210106281634408	no	1044	0.268709191258449	962	NA	FF|FT	RESPONSE TO DNA DAMAGE|ION HOMEOSTASIS|CARBOHYDRATE METABOLISM|ION HOMEOSTASIS			Transcriptional activator involved in maintenance of ion homeostasis and protection against DNA damage caused by bleomycin and other oxidants, contains a C-terminal leucine-rich repeat	DNA repair|cellular carbohydrate metabolic process	transcription coactivator activity	cytoplasm
YJL107C_p	YJL107C	YJL107C	hom	Uncharacterized	0.805907910050372	0.210147974991937	no	1045	0.192463679221857	683	NA					Putative protein of unknown function; expression is induced by activation of the HOG1 mitogen-activated signaling pathway and this induction is Hog1p/Pbs2p dependent; YJL107C and adjacent ORF, YJL108C are merged in related fungi	biological_process	molecular_function	cellular_component
YDL114W_p	YDL114W	YDL114W	hom	Uncharacterized	0.804521746731822	0.210547857584717	no	1046	0.213951793168829	715	NA	FT	OXIDATION-REDUCTION PROCESS			Putative short-chain dehydrogenase/reductase; YDL114W is not an essential gene	biological_process	molecular_function	integral to membrane
YER095W	YER095W	RAD51	hom	Verified	0.804391924723682	0.210585331699059	no	1047	0.240558192651101	826	NA	FF|FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Strand exchange protein, forms a helical filament with DNA that searches for homology; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; homolog of Dmc1p and bacterial RecA protein	strand invasion|telomere maintenance via recombination|heteroduplex formation|meiotic joint molecule formation|reciprocal meiotic recombination|double-strand break repair via single-strand annealing	recombinase activity|single-stranded DNA binding|DNA-dependent ATPase activity	condensed nuclear chromosome|nuclear chromosome
YAL044C	YAL044C	GCV3	hom	Verified	0.803462460957085	0.210853742813214	no	1048	0.246240220661418	847	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		H subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; also required for all protein lipoylation; expression is regulated by levels of 5,10-methylene-THF	glycine catabolic process|one-carbon metabolic process|protein lipoylation	glycine dehydrogenase (decarboxylating) activity	mitochondrion|glycine cleavage complex
YGR254W	YGR254W	ENO1	hom	Verified	0.802924069384138	0.211009311582191	no	1049	0.196038096923816	659	NA	FT	MEMBRANE ORGANIZATION|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Enolase I, a phosphopyruvate hydratase; catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate during glycolysis and the reverse reaction during gluconeogenesis; expression is repressed in response to glucose; protein abundance increases in response to DNA replication stress	regulation of vacuole fusion, non-autophagic|gluconeogenesis|glycolysis	phosphopyruvate hydratase activity	mitochondrion|phosphopyruvate hydratase complex|plasma membrane|fungal-type vacuole|cytoplasm
YDL033C	YDL033C	SLM3	hom	Verified	0.802440378411761	0.211149131920826	no	1050	0.228563455201608	791	NA	FT	RNA PROCESSING|MITOCHONDRION ORGANIZATION	MITOCHONDRION		tRNA-specific 2-thiouridylase, responsible for 2-thiolation of the wobble base of mitochondrial tRNAs; human ortholog is implicated in myoclonus epilepsy associated with ragged red fibers (MERRF)	mitochondrial tRNA thio-modification	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity	mitochondrion
YDL024C	YDL024C	DIA3	hom	Verified	0.80236858865789	0.211169888779929	no	1051	0.238897566993098	836	NA					Protein of unknown function, involved in invasive and pseudohyphal growth	pseudohyphal growth|invasive growth in response to glucose limitation	acid phosphatase activity	fungal-type cell wall
YKL027W	YKL027W	YKL027W	hom	Verified	0.800557862075934	0.211693826717382	no	1052	0.215616866974719	753	NA	FT		MITOCHONDRION		Protein of unknown function, localized to the mitochondrial outer membrane	biological_process	molecular_function	mitochondrial outer membrane|mitochondrion
YPL104W	YPL104W	MSD1	hom	Verified	0.800543690489417	0.211697930297141	no	1053	0.240131378344446	843	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial aspartyl-tRNA synthetase, required for acylation of aspartyl-tRNA; yeast and bacterial aspartyl-, asparaginyl-, and lysyl-tRNA synthetases contain regions with high sequence similarity, suggesting a common ancestral gene	mitochondrial aspartyl-tRNA aminoacylation	aspartate-tRNA ligase activity	mitochondrion
YKR027W	YKR027W	BCH2	hom	Verified	0.799834724893857	0.211903280550719	no	1054	0.213233375150179	728	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	MITOCHONDRION|GOLGI APPARATUS		Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex with Chs5p to mediate export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; BCH2 has a paralog, CHS6, that arose from the whole genome duplication	Golgi to plasma membrane transport|fungal-type cell wall chitin biosynthetic process	molecular_function	trans-Golgi network transport vesicle|mitochondrion|clathrin-coated vesicle|exomer complex
YNL285W_d	YNL285W	YNL285W	hom	Dubious	0.799346046330969	0.21204489298761	no	1055	0.203241020657384	681	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YNL237W	YNL237W	YTP1	hom	Verified	0.798234300406208	0.212367268012496	no	1056	0.277115911015712	973	NA	FF|FT		MITOCHONDRION		Probable type-III integral membrane protein of unknown function, has regions of similarity to mitochondrial electron transport proteins	biological_process	molecular_function	integral to membrane|membrane
YLR419W_p	YLR419W	YLR419W	hom	Uncharacterized	0.797997817654119	0.212435878274781	no	1057	0.208307982344213	676	NA	FT		MITOCHONDRION		Putative helicase with limited sequence similarity to human Rb protein; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YLR419W is not an essential gene	biological_process	molecular_function	mitochondrion|cytoplasm
YMR031W-A_d	YMR031W-A	YMR031W-A	hom	Dubious	0.797638240161938	0.212540226577757	no	1058	0.211070751355588	694	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays shortened telomeres; partially overlaps the uncharacterized ORF YMR031C	Unknown	Unknown	Unknown
YPL115C	YPL115C	BEM3	hom	Verified	0.796645623431898	0.212828436306494	no	1059	0.240301749778599	825	NA	FT	SIGNALING	SITE OF POLARIZED GROWTH		Rho GTPase activating protein (RhoGAP) involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assembly	negative regulation of Rho protein signal transduction|establishment of cell polarity	Rho GTPase activator activity|phosphatidylinositol-3-phosphate binding	cell cortex|incipient cellular bud site|mating projection tip|cytoplasm|cellular bud tip
YNL196C_p	YNL196C	SLZ1	hom	Uncharacterized	0.796453116331624	0.212884357813925	no	1060	0.222988719366683	800	NA					Sporulation-specific protein with a leucine zipper motif	biological_process	molecular_function	cellular_component
YDR520C_p	YDR520C	URC2	hom	Uncharacterized	0.793952221383477	0.213611623346249	no	1061	0.249748645329171	822	NA	FT	TRANSCRIPTION FROM RNA POL II|NUCLEOTIDE METABOLISM	NUCLEUS		Putative Zn(II)2Cys6 motif containing transcription factor; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; similar to S. kluyveri Urc2p involved in uracil catabolism	uracil catabolic process	sequence-specific DNA binding	nucleus|cytoplasm
YIL163C_p	YIL163C	YIL163C	hom	Uncharacterized	0.793608426587737	0.213711712649399	no	1062	0.200505594146624	688	NA					Protein of unknown function; mRNA identified as translated by ribosome profiling data	biological_process	molecular_function	cellular_component
YAL012W	YAL012W	CYS3	hom	Verified	0.793352327659296	0.213786288722541	no	1063	0.249906703952012	857	NA	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM			Cystathionine gamma-lyase, catalyzes one of the two reactions involved in the transsulfuration pathway that yields cysteine from homocysteine with the intermediary formation of cystathionine; protein abundance increases in response to DNA replication stress	sulfur amino acid metabolic process|cysteine biosynthetic process|cysteine biosynthetic process via cystathionine|transsulfuration|cysteine metabolic process	cystathionine gamma-lyase activity	cytoplasm
YNR059W	YNR059W	MNT4	hom	Verified	0.792722228278168	0.213969838326689	no	1064	0.212716358535795	745	NA	FT	CARBOHYDRATE METABOLISM			Putative alpha-1,3-mannosyltransferase, not required for protein O-glycosylation	protein O-linked glycosylation	alpha-1,3-mannosyltransferase activity	cellular_component
YBL091C	YBL091C	MAP2	hom	Verified	0.791614619790832	0.214292709853996	no	1065	0.213618419667356	720	NA	FT	PROTEOLYSIS			Methionine aminopeptidase, catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map1p	protein initiator methionine removal involved in protein maturation	metalloaminopeptidase activity	cytoplasm
YLR319C	YLR319C	BUD6	hom	Verified	0.791322640122778	0.21437787006683	no	1066	0.227626173788607	722	NA	FT	CELL CYCLE|CHROMATIN ORGANIZATION|SIGNALING|CELL DIVISION|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Actin- and formin-interacting protein; stimulates actin cable nucleation by recruiting actin monomers to Bni1p; involved in polarized cell growth; isolated as bipolar budding mutant; potential Cdc28p substrate	bipolar cellular bud site selection|positive regulation of formin-nucleated actin cable assembly|cellular bud site selection|Rho protein signal transduction|extrachromosomal circular DNA localization involved in cell aging|establishment of cell polarity|response to osmotic stress|cytokinesis	cytoskeletal regulatory protein binding	polarisome|actin cap|spindle pole body|mating projection tip
YBR106W	YBR106W	PHO88	hom	Verified	0.790632849726136	0.214579135850491	no	1067	0.285012472635726	1008	NA	FF|FT	ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Probable membrane protein, involved in phosphate transport; pho88 pho86 double null mutant exhibits enhanced synthesis of repressible acid phosphatase at high inorganic phosphate concentrations	phosphate ion transport	molecular_function	mitochondrion|membrane
YLR085C	YLR085C	ARP6	hom	Verified	0.789981627605934	0.214769249011076	no	1068	0.260957000112099	913	NA	FF|FT	CHROMATIN ORGANIZATION	NUCLEUS|CHROMOSOME		Actin-related protein that binds nucleosomes; a component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A	chromatin remodeling|histone exchange	nucleosome binding	Swr1 complex|cytoplasm
YHR110W	YHR110W	ERP5	hom	Verified	0.788684015373812	0.215148356356714	no	1069	0.196257849716932	659	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport	vesicle-mediated transport	molecular_function	integral to membrane
YJR004C	YJR004C	SAG1	hom	Verified	0.788500836324227	0.215201904790392	no	1070	0.215291782256105	692	NA					Alpha-agglutinin of alpha-cells, binds to Aga1p during agglutination, N-terminal half is homologous to the immunoglobulin superfamily and contains binding site for a-agglutinin, C-terminal half is highly glycosylated and contains GPI anchor	agglutination involved in conjugation with cellular fusion	cell adhesion molecule binding	fungal-type cell wall
YBR059C	YBR059C	AKL1	hom	Verified	0.788495906784631	0.215203345941567	no	1071	0.219366581502002	743	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION	SITE OF POLARIZED GROWTH		Ser-Thr protein kinase, member (with Ark1p and Prk1p) of the Ark kinase family; involved in endocytosis and actin cytoskeleton organization	regulation of endocytosis|protein phosphorylation|actin cytoskeleton organization	protein kinase activity	cellular bud neck|cytoplasm
YNL009W	YNL009W	IDP3	hom	Verified	0.788196429342574	0.215290908695234	no	1072	0.208398528856562	710	NA	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Peroxisomal NADP-dependent isocitrate dehydrogenase; catalyzes oxidation of isocitrate to alpha-ketoglutarate with the formation of NADP(H+), required for growth on unsaturated fatty acids; IDP3 has a paralog, IDP2, that arose from the whole genome duplication	NADPH regeneration|fatty acid beta-oxidation|isocitrate metabolic process	isocitrate dehydrogenase (NADP+) activity	mitochondrion|peroxisome|cytoplasm
YDR153C	YDR153C	ENT5	hom	Verified	0.78774595486804	0.21542265966907	no	1073	0.197012574181644	650	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM		Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p, clathrin adaptor complex AP-1, and clathrin	late endosome to vacuole transport via multivesicular body sorting pathway|early endosome to Golgi transport|Golgi to endosome transport	clathrin binding|phosphatidylinositol-3,5-bisphosphate binding	endosome|clathrin vesicle coat|cytoplasm
YCR022C_d	YCR022C	YCR022C	hom	Dubious	0.785746996774272	0.216007862066221	no	1074	0.198376666503678	677	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR022C is not an essential gene	Unknown	Unknown	Unknown
YGR015C_p	YGR015C	YGR015C	hom	Uncharacterized	0.785072384661799	0.216205564916231	no	1075	0.231220690279036	782	NA	FT		MITOCHONDRION		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion	biological_process	molecular_function	mitochondrion
YDR482C	YDR482C	CWC21	hom	Verified	0.784361684353546	0.216413957116021	no	1076	0.233787479462838	797	NA	FT	RNA PROCESSING	NUCLEUS		Protein involved in RNA splicing by the spliceosome; component of a complex containing Cef1p; interacts genetically with ISY1 and BUD13; may bind RNA; has similarity to S. pombe Cwf21p	mRNA splicing, via spliceosome	molecular_function	U2-type spliceosomal complex
YBR217W	YBR217W	ATG12	hom	Verified	0.784304146428578	0.216430833524534	no	1077	0.222921868535275	757	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS			Conserved ubiquitin-like modifier involved in autophagy and the Cvt pathway; conjugated to Atg5p to form a complex involved in Atg8p lipidation; Atg12p-Atg5p also forms a complex with Atg16p that is required for autophagosome formation	C-terminal protein lipidation|piecemeal microautophagy of nucleus|mitochondrion degradation|CVT pathway|autophagic vacuole assembly	Atg8 ligase activity|protein tag	Atg12-Atg5-Atg16 complex|pre-autophagosomal structure
YOL095C	YOL095C	HMI1	hom	Verified	0.7840089385626	0.216517432714559	no	1078	0.234603818837492	783	NA	FT	RESPONSE TO DNA DAMAGE|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial inner membrane localized ATP-dependent DNA helicase, required for the maintenance of the mitochondrial genome; not required for mitochondrial transcription; has homology to E. coli helicase uvrD	mitochondrial genome maintenance|mitochondrial DNA metabolic process	ATP-dependent 3'-5' DNA helicase activity	mitochondrion|mitochondrial matrix
YFR038W	YFR038W	IRC5	hom	Verified	0.783940067225826	0.216537638996346	no	1079	0.212426606275241	744	NA	FT		NUCLEUS		Putative ATPase containing the DEAD/H helicase-related sequence motif; null mutant displays increased levels of spontaneous Rad52p foci	mitotic recombination	molecular_function	cellular_component
YLR056W	YLR056W	ERG3	hom	Verified	0.782407278446337	0.216987628840945	no	1080	0.267829649330638	939	NA	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		C-5 sterol desaturase, glycoprotein that catalyzes the introduction of a C-5(6) double bond into episterol, a precursor in ergosterol biosynthesis; mutants are viable, but cannot grow on non-fermentable carbon sources; substrate of the HRD ubiquitin ligase	ergosterol biosynthetic process	C-5 sterol desaturase activity	integral to membrane|endoplasmic reticulum|endoplasmic reticulum lumen
YBL071W-A	YBL071W-A	KTI11	hom	Verified	0.779639758231087	0.217801473444706	no	1081	0.269392383011395	917	NA	FT	RNA PROCESSING	NUCLEUS		Zn-ribbon protein that co-purifies with Dph1 and Dph2 in a complex required for synthesis of diphthamide on translation factor eEF2 and with Elongator subunits Iki3p, Elp2p, and Elp3p involved in modification of wobble nucleosides in tRNAs	peptidyl-diphthamide biosynthetic process from peptidyl-histidine|tRNA wobble uridine modification	electron carrier activity|iron ion binding|zinc ion binding	nucleus|cytoplasm
YLL052C	YLL052C	AQY2	hom	Verified	0.777957525234994	0.218297026841983	no	1082	0.225396463370248	775	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|PLASMA MEMBRANE		Water channel that mediates the transport of water across cell membranes, only expressed in proliferating cells, controlled by osmotic signals, may be involved in freeze tolerance; disrupted by a stop codon in many S. cerevisiae strains	water transport	water channel activity	plasma membrane|endoplasmic reticulum membrane
YBL068W	YBL068W	PRS4	hom	Verified	0.777311427376172	0.218487527328243	no	1083	0.175860350397526	602	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM			5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; PRS4 has a paralog, PRS2, that arose from the whole genome duplication	fungal-type cell wall organization|5-phosphoribose 1-diphosphate biosynthetic process	ribose phosphate diphosphokinase activity	cytoplasm
YJL161W_p	YJL161W	FMP33	hom	Uncharacterized	0.776384526816393	0.21876098896703	no	1084	0.195136888601666	651	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YBL090W	YBL090W	MRP21	hom	Verified	0.775857234247019	0.218916642906472	no	1085	0.249407533389338	857	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the small subunit; MRP21 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequences	mitochondrial translational initiation|mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YKL062W	YKL062W	MSN4	hom	Verified	0.775711031833527	0.218959812353972	no	1086	0.215574937648835	708	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO NUTRIENT LEVELS|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		Transcriptional activator; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression; MSN4 has a paralog, MSN2, that arose from the whole genome duplication	positive regulation of transcription from RNA polymerase II promoter in response to heat stress|positive regulation of transcription from RNA polymerase II promoter in response to a hypotonic environment|positive regulation of transcription from RNA polymerase II promoter in response to alkalinity|positive regulation of transcription from RNA polymerase II promoter in response to amino acid starvation|positive regulation of transcription from RNA polymerase II promoter in response to zinc ion starvation|positive regulation of transcription from RNA polymerase II promoter in response to acidity|chromatin remodeling|regulation of replicative cell aging by regulation of transcription from RNA polymerase II promoter in response to caloric restriction|positive regulation of transcription from RNA polymerase II promoter in response to hydrogen peroxide|positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance|positive regulation of transcription from RNA polymerase II promoter in response to increased salt|cellular response to acidity|positive regulation of transcription from RNA polymerase II promoter in response to freezing|positive regulation of transcription from RNA polymerase II promoter in response to ethanol|replicative cell aging|age-dependent response to oxidative stress involved in chronological cell aging|positive regulation of transcription from RNA polymerase II promoter in response to hydrostatic pressure|positive regulation of transcription from RNA polymerase II promoter in response to nitrosative stress|positive regulation of transcription from RNA polymerase II promoter in response to cold|positive regulation of transcription from RNA polymerase II promoter in response to glucose starvation	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity|core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding	cytosol|nucleus
YER050C	YER050C	RSM18	hom	Verified	0.774600577108178	0.219287858096825	no	1087	0.249749914417996	857	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YGL190C	YGL190C	CDC55	hom	Verified	0.774429925773243	0.219338296206159	no	1088	0.305234548340086	1049	NA	FT	CELL CYCLE|SIGNALING	NUCLEUS|SITE OF POLARIZED GROWTH		Non-essential regulatory subunit B of protein phosphatase 2A (PP2A); localization to the cytoplasm requires Zds1p and Zds2p and promotes mitotic entry; localization to the nucleus prevents mitotic exit; required for correct nuclear division and chromosome segregation in meiosis; maintains nucleolar sequestration of Cdc14p during early meiosis; limits formation of PP2A-Rts1p holocomplexes to ensure timely dissolution of sister chromosome cohesion	negative regulation of exit from mitosis|positive regulation of G2/M transition of mitotic cell cycle|cell shape checkpoint|protein dephosphorylation	protein phosphatase type 2A regulator activity	nucleus|cellular bud neck|cytoplasm|cellular bud tip
YJL073W	YJL073W	JEM1	hom	Verified	0.77428669789794	0.219380634118794	no	1089	0.226463529064528	819	NA	FT	PROTEOLYSIS	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM		DnaJ-like chaperone required for nuclear membrane fusion during mating, localizes to the ER membrane; exhibits genetic interactions with KAR2	karyogamy involved in conjugation with cellular fusion|ER-associated protein catabolic process|protein folding in endoplasmic reticulum	unfolded protein binding|chaperone binding	endoplasmic reticulum|nuclear outer membrane-endoplasmic reticulum membrane network
YGL220W	YGL220W	FRA2	hom	Verified	0.774264118890532	0.219387308862862	no	1090	0.218947319558141	732	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Protein involved in negative regulation of transcription of iron regulon; forms an iron independent complex with Fra2p, Grx3p, and Grx4p; null mutant fails to repress iron regulon and is sensitive to nickel	negative regulation of transcription from RNA polymerase II promoter in response to iron	molecular_function	cytosol|nucleus|cytoplasm
YPR073C	YPR073C	LTP1	hom	Verified	0.773884743240427	0.219499476299779	no	1091	0.20236572222686	705	NA	FT		NUCLEUS		Protein phosphotyrosine phosphatase of unknown cellular role; activated by adenine	protein dephosphorylation	protein tyrosine phosphatase activity	nucleus|cytoplasm
YDR540C	YDR540C	IRC4	hom	Verified	0.77325790882837	0.219684880363608	no	1092	0.260387481192868	908	NA	FF|FT		NUCLEUS		Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus	mitotic recombination	molecular_function	nucleus|cytoplasm
YGR233C	YGR233C	PHO81	hom	Verified	0.771531877344079	0.220195867590683	no	1093	0.231708094613986	792	NA	FT	LIPID METABOLISM	NUCLEUS		Cyclin-dependent kinase (CDK) inhibitor; regulates Pho80p-Pho85p and Pcl7p-Pho85p cyclin-CDK complexes in response to phosphate levels; inhibitory activity for Pho80p-Pho85p requires myo-D-inositol heptakisphosphate (IP7) generated by Vip1p; relative distribution to the nucleus increases upon DNA replication stress	phosphate-containing compound metabolic process	cyclin-dependent protein kinase inhibitor activity	nucleus|cytoplasm
YDL040C	YDL040C	NAT1	hom	Verified	0.770931367302546	0.220373806754649	no	1094	0.210964799991161	709	NA	FT		MITOCHONDRION	RIBOSOME	Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing	N-terminal protein amino acid acetylation	peptide alpha-N-acetyltransferase activity	mitochondrion|NatA complex|cytosolic ribosome
YCR005C	YCR005C	CIT2	hom	Verified	0.770101919712753	0.22061971867659	no	1095	0.212096327120119	684	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Citrate synthase; catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate, peroxisomal isozyme involved in glyoxylate cycle; expression is controlled by Rtg1p and Rtg2p transcription factors; CIT2 has a paralog, CIT1, that arose from the whole genome duplication	glyoxylate cycle|glutamate biosynthetic process|citrate metabolic process	citrate (Si)-synthase activity	mitochondrion|peroxisome
YMR023C	YMR023C	MSS1	hom	Verified	0.767355300332465	0.221435148706752	no	1096	0.186562494067611	631	NA	FT	RNA PROCESSING|SIGNALING|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial protein, forms a heterodimer complex with Mto1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; similar to human GTPBP3	mitochondrial tRNA wobble uridine modification|Unknown	GTP binding	mitochondrion|mitochondrial inner membrane
YPL101W	YPL101W	ELP4	hom	Verified	0.766912342387406	0.221566817436738	no	1097	0.252172981757118	866	NA	FT	TRANSCRIPTION FROM RNA POL II|RNA PROCESSING	NUCLEUS		Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity	regulation of transcription from RNA polymerase II promoter|tRNA wobble uridine modification	ATPase activity|tRNA binding	Elongator holoenzyme complex|cytoplasm
YML054C	YML054C	CYB2	hom	Verified	0.766645630399577	0.221646118841063	no	1098	0.183744253020798	599	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Cytochrome b2 (L-lactate cytochrome-c oxidoreductase), component of the mitochondrial intermembrane space, required for lactate utilization; expression is repressed by glucose and anaerobic conditions	lactate metabolic process	L-lactate dehydrogenase (cytochrome) activity	mitochondrion|mitochondrial intermembrane space
YOR154W_p	YOR154W	SLP1	hom	Uncharacterized	0.765788929373873	0.221900951219719	no	1099	0.19072269810678	648	NA					Glycosylated integral ER membrane protein of unknown function; forms an ER-membrane associated protein complex with Emp65p; member of the SUN-like family of proteins; genetic interactions suggest a role in folding of ER membrane proteins; required for nuclear envelope localization of Mps3p	protein folding in endoplasmic reticulum	molecular_function	cellular_component
YNL173C	YNL173C	MDG1	hom	Verified	0.76529738638216	0.222047240013202	no	1100	0.237956648805275	812	NA	FT	SIGNALING	PLASMA MEMBRANE		Plasma membrane protein involved in G-protein mediated pheromone signaling pathway; overproduction suppresses bem1 mutations	pheromone-dependent signal transduction involved in conjugation with cellular fusion	molecular_function	membrane raft|plasma membrane
YDL059C	YDL059C	RAD59	hom	Verified	0.764629347296679	0.222246144285609	no	1101	0.240639070963367	837	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		Protein involved DNA double-strand break repair; repairs breaks in DNA during vegetative growth via recombination and single-strand annealing; anneals complementary single-stranded DNA; forms nuclear foci upon DNA replication stress; required for loading of Rad52p to DSBs; paralog of Rad52p	DNA strand renaturation|telomere maintenance via recombination|double-strand break repair via break-induced replication|double-strand break repair via single-strand annealing	protein binding	nucleus
YMR003W	YMR003W	AIM34	hom	Verified	0.764128937435344	0.222395204628696	no	1102	0.218349058462297	736	NA	FT		MITOCHONDRION		Protein of unknown function; GFP-fusion protein localizes to the mitochondria; null mutant is viable and displays reduced frequency of mitochondrial genome loss	biological_process	molecular_function	mitochondrion
YBR291C	YBR291C	CTP1	hom	Verified	0.763924775313396	0.222456036104009	no	1103	0.230853079917832	813	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Mitochondrial inner membrane citrate transporter, member of the mitochondrial carrier family	mitochondrial citrate transport|transmembrane transport	tricarboxylate secondary active transmembrane transporter activity	mitochondrion|integral to membrane|mitochondrial inner membrane
YDR479C	YDR479C	PEX29	hom	Verified	0.763101393477981	0.222701464536803	no	1104	0.231625850702622	792	NA	FT	PEROXISOME ORGANIZATION			Peroxisomal integral membrane peroxin; involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p; forms ER foci upon DNA replication stress	peroxisome organization	molecular_function	integral to membrane|peroxisomal membrane
YGR039W_d	YGR039W	YGR039W	hom	Dubious	0.759824645545695	0.223679704537339	no	1105	0.2279921889266	781	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the Autonomously Replicating Sequence ARS722	Unknown	Unknown	Unknown
YJR125C	YJR125C	ENT3	hom	Verified	0.759314321219757	0.223832276293712	no	1106	0.221251466437467	748	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS|CYTOSKELETON		Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p	late endosome to vacuole transport via multivesicular body sorting pathway|early endosome to Golgi transport|actin filament organization|endocytosis|actin cortical patch assembly|Golgi to endosome transport	protein binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding	clathrin vesicle coat|actin cortical patch
YGR100W	YGR100W	MDR1	hom	Verified	0.759082026329384	0.223901745124634	no	1107	0.232950229655078	800	NA	FT	PROTEIN LOCALIZATION|SIGNALING|NUCLEOTIDE METABOLISM			Cytoplasmic GTPase-activating protein for Ypt/Rab transport GTPases Ypt6p, Ypt31p and Sec4p; involved in recycling of internalized proteins and regulation of Golgi secretory function	intracellular protein transport	Rab GTPase activator activity	cytoplasm
YDR030C	YDR030C	RAD28	hom	Verified	0.757998430755491	0.224225961083166	no	1108	0.224640934853163	747	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		Protein involved in DNA repair, related to the human CSA protein that is involved in transcription-coupled repair nucleotide excision repair	DNA repair	molecular_function	nucleus
YKL101W	YKL101W	HSL1	hom	Verified	0.757705834243669	0.224313552770948	no	1109	0.233234889419205	800	NA	FT	CELL CYCLE|CELL DIVISION|PROTEIN PHOSPHORYLATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Nim1p-related protein kinase that regulates the morphogenesis and septin checkpoints; associates with the assembled septin filament; required along with Hsl7p for bud neck recruitment, phosphorylation, and degradation of Swe1p	G2/M transition of mitotic cell cycle|regulation of cell cycle|cell shape checkpoint|protein autophosphorylation|protein phosphorylation|septin checkpoint	protein kinase activity	cellular bud neck|septin ring
YKL068W	YKL068W	NUP100	hom	Verified	0.757214075378649	0.224460809446383	no	1110	0.20994746736173	729	NA	FT	PROTEIN LOCALIZATION|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier and is involved in gene tethering at the nuclear periphery; homologous to Nup116p	positive regulation of transcription, DNA-dependent|mRNA export from nucleus|NLS-bearing substrate import into nucleus|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|protein import into nucleus|protein targeting to nuclear inner membrane|mRNA export from nucleus in response to heat stress	nucleocytoplasmic transporter activity|structural constituent of nuclear pore	nuclear pore central transport channel|integral to membrane|nuclear pore
YFR017C	YFR017C	IGD1	hom	Verified	0.757197293010489	0.224465835876751	no	1111	0.228795629132787	752	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY			Cytoplasmic protein that inhibits Gdb1p glycogen debranching activity; required for normal intracellular accumulation of glycogen; phosphorylated in vivo; expression increases during wine fermentation; protein abundance increases in response to DNA replication stress; IGD1 has a paralog, YOL024W, that arose from the whole genome duplication	negative regulation of glycogen catabolic process	enzyme inhibitor activity	cytoplasm
YOL064C	YOL064C	MET22	hom	Verified	0.756944513835415	0.224541552639389	no	1112	0.24585334715575	861	NA	FT	KETONE METABOLISM|LIPID METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Bisphosphate-3'-nucleotidase, involved in salt tolerance and methionine biogenesis; dephosphorylates 3'-phosphoadenosine-5'-phosphate and 3'-phosphoadenosine-5'-phosphosulfate, intermediates of the sulfate assimilation pathway	methionine biosynthetic process|hyperosmotic salinity response|sulfate assimilation	3'(2'),5'-bisphosphate nucleotidase activity	cellular_component
YER046W	YER046W	SPO73	hom	Verified	0.752869970331595	0.225764027543725	no	1113	0.213853681532736	712	NA	FT	CELL WALL ORG/BIOGENESIS			Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensible for both nuclear divisions during meiosis	ascospore wall assembly|ascospore formation	molecular_function	cytosol
YMR122C_d	YMR122C	YMR122C	hom	Dubious	0.751361476381491	0.226217570253397	no	1114	0.256805915407973	876	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YPR184W	YPR184W	GDB1	hom	Verified	0.750838572154668	0.226374906334781	no	1115	0.229587823565445	820	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS|MITOCHONDRION		Glycogen debranching enzyme; contains glucanotranferase and alpha-1,6-amyloglucosidase activities; required for glycogen degradation; phosphorylated in mitochondria; activity is inhibited by Igd1p; protein abundance increases in response to DNA replication stress	glycogen catabolic process	4-alpha-glucanotransferase activity|amylo-alpha-1,6-glucosidase activity	mitochondrion|cytoplasm
YGL224C	YGL224C	SDT1	hom	Verified	0.74951891430698	0.226772251420771	no	1116	0.223099912456478	755	NA					Pyrimidine nucleotidase; overexpression suppresses the 6-AU sensitivity of transcription elongation factor S-II, as well as resistance to other pyrimidine derivatives	pyrimidine nucleobase metabolic process	nucleotidase activity	cellular_component
YGL063W	YGL063W	PUS2	hom	Verified	0.748318714776912	0.227133969398831	no	1117	0.221993778028426	772	NA	FT	RNA PROCESSING	MITOCHONDRION		Mitochondrial tRNA:pseudouridine synthase; acts at positions 27 and 28, but not at position 72; efficiently and rapidly targeted to mitochondria, specifically dedicated to mitochondrial tRNA modification	tRNA pseudouridine synthesis	pseudouridine synthase activity	mitochondrion
YLR178C	YLR178C	TFS1	hom	Verified	0.745465683585588	0.227995124494206	no	1118	0.19211527224754	656	NA	FT	SIGNALING|PROTEOLYSIS			Protein that interacts with and inhibits carboxypeptidase Y and Ira2p; phosphatidylethanolamine-binding protein (PEBP) family member; targets to vacuolar membranes during stationary phase; acetylated by NatB N-terminal acetyltransferase; protein abundance increases in response to DNA replication stress	regulation of Ras protein signal transduction|regulation of proteolysis	lipid binding|peptidase inhibitor activity|phospholipid binding	fungal-type vacuole lumen|fungal-type vacuole membrane|cytoplasm
YDL200C	YDL200C	MGT1	hom	Verified	0.743068420257293	0.228720128894017	no	1119	0.249432587735563	835	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		DNA repair methyltransferase (6-O-methylguanine-DNA methylase) involved in protection against DNA alkylation damage	DNA dealkylation involved in DNA repair	methylated-DNA-[protein]-cysteine S-methyltransferase activity	nucleus
YKL040C	YKL040C	NFU1	hom	Verified	0.743048628904703	0.228726119775652	no	1120	0.206381562315356	682	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|COFACTOR METABOLISM	MITOCHONDRION		Protein involved in iron metabolism in mitochondria; similar to NifU, which is a protein required for the maturation of the Fe/S clusters of nitrogenase in nitrogen-fixing bacteria	cellular iron ion homeostasis|iron-sulfur cluster assembly|intracellular sequestering of iron ion	molecular_function	mitochondrion|mitochondrial matrix
YDR115W	YDR115W	YDR115W	hom	Verified	0.742952846325044	0.228755114597187	no	1121	0.230241358056958	740	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Putative mitochondrial ribosomal protein of the large subunit; similar to E. coli L34 ribosomal protein; required for respiratory growth, as are most mitochondrial ribosomal proteins; protein increases in abundance and relocalizes to the plasma membrane upon DNA replication stress	mitochondrial translation	structural constituent of ribosome	mitochondrial large ribosomal subunit
YPR092W_d	YPR092W	YPR092W	hom	Dubious	0.742815320004029	0.228796749482716	no	1122	0.2380759803442	816	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YMR253C_p	YMR253C	YMR253C	hom	Uncharacterized	0.742552687481891	0.228876270988785	no	1123	0.222584575400954	789	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YMR253C is not an essential gene	biological_process	molecular_function	integral to membrane|cytoplasm
YDR178W	YDR178W	SDH4	hom	Verified	0.742537393523122	0.228880902266512	no	1124	0.258375989632557	877	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Membrane anchor subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain	mitochondrial electron transport, succinate to ubiquinone|cellular respiration|tricarboxylic acid cycle	succinate dehydrogenase (ubiquinone) activity	mitochondrial respiratory chain complex II|mitochondrion
YGR021W_p	YGR021W	YGR021W	hom	Uncharacterized	0.741931249677475	0.229064495549557	no	1125	0.239320551115863	827	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YKR048C	YKR048C	NAP1	hom	Verified	0.741256921182974	0.229268838137351	no	1126	0.237963738457756	834	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|CHROMATIN ORGANIZATION|CELL DIVISION	NUCLEUS|SITE OF POLARIZED GROWTH|CHROMOSOME		Protein that interacts with mitotic cyclin Clb2p; required for the regulation of microtubule dynamics during mitosis; controls bud morphogenesis; involved in the transport of H2A and H2B histones to the nucleus; phosphorylated by CK2; protein abundance increases in response to DNA replication stress	budding cell bud growth|M phase of mitotic cell cycle|nucleosome disassembly|protein import into nucleus|nucleosome assembly	cyclin binding|histone binding	nucleus|nuclear nucleosome|cytoplasm
YMR204C	YMR204C	INP1	hom	Verified	0.741042420775065	0.229333859878201	no	1127	0.215247026715583	715	NA	FT	PEROXISOME ORGANIZATION			Peripheral membrane protein of peroxisomes involved in peroxisomal inheritance; recruitment to peroxisomes is mediated by interaction with Pex3p at the peroxisomal membrane	peroxisome inheritance	molecular_function	peroxisome|extrinsic to intraperoxisomal membrane
YDR025W	YDR025W	RPS11A	hom	Verified	0.740816866354662	0.229402243582806	no	1128	0.237393975597016	799	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S11 and bacterial S17; RPS11A has a paralog, RPS11B, that arose from the whole genome duplication	cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|ribosomal small subunit assembly	structural constituent of ribosome	cytosolic small ribosomal subunit|90S preribosome
YEL029C	YEL029C	BUD16	hom	Verified	0.740250088054392	0.22957413015027	no	1129	0.27070567637633	941	NA	FT	CELL CYCLE|CELL DIVISION|COFACTOR METABOLISM	NUCLEUS		Putative pyridoxal kinase, a key enzyme involved in pyridoxal 5'-phosphate synthesis, the active form of vitamin B6; required for genome integrity; involved in bud-site selection; similarity to yeast BUD17 and human pyridoxal kinase (PDXK)	pyridoxal phosphate biosynthetic process|cellular bud site selection	pyridoxal kinase activity	cytoplasm
YDR174W	YDR174W	HMO1	hom	Verified	0.739866246621575	0.229690578514637	no	1130	0.229268584681743	823	NA	FT	TRANSCRIPTION FROM RNA POL II|RIBOSOME BIOGENESIS|CHROMATIN ORGANIZATION	NUCLEUS|CHROMOSOME		Chromatin associated high mobility group (HMG) family member involved in genome maintenance; rDNA-binding component of the Pol I transcription system; associates with a 5'-3' DNA helicase and Fpr1p, a prolyl isomerase	regulation of transcription from RNA polymerase I promoter|regulation of transcription by chromatin organization|regulation of ribosomal protein gene transcription from RNA polymerase II promoter	double-stranded DNA binding|four-way junction DNA binding|DNA binding, bending	nuclear chromatin|nucleolus|cytoplasm
YOR173W	YOR173W	DCS2	hom	Verified	0.739368879522567	0.229841517060897	no	1131	0.22626447132418	796	NA					Non-essential, stress induced regulatory protein; modulates m7G-oligoribonucleotide metabolism; inhibits Dcs1p; regulated by Msn2p, Msn4p, and the Ras-cAMP-cAPK signaling pathway; mutant has increased aneuploidy tolerance	deadenylation-dependent decapping of nuclear-transcribed mRNA	m7G(5')pppN diphosphatase activity	cytoplasmic mRNA processing body|cytoplasm
YDL234C	YDL234C	GYP7	hom	Verified	0.739367637348313	0.229841894099399	no	1132	0.196479110652875	666	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING|NUCLEOTIDE METABOLISM			GTPase-activating protein for yeast Rab family members including: Ypt7p (most effective), Ypt1p, Ypt31p, and Ypt32p (in vitro); involved in vesicle mediated protein trafficking	regulation of vacuole fusion, non-autophagic|vesicle-mediated transport	Rab GTPase activator activity	cytoplasm
YPL138C	YPL138C	SPP1	hom	Verified	0.738735789379389	0.230033724480813	no	1133	0.234186752459281	799	NA	FT	CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS		Subunit of COMPASS (Set1C), a complex which methylates histone H3 on lysine 4 and is required in telomeric transcriptional silencing; interacts with Orc2p; PHD finger domain protein similar to human CGBP, an unmethylated CpG binding protein	histone H3-K4 methylation|regulation of transcription, DNA-dependent|chromatin silencing at telomere	histone methyltransferase activity (H3-K4 specific)|chromatin binding|methylated histone residue binding	Set1C/COMPASS complex
YBL087C	YBL087C	RPL23A	hom	Verified	0.738734835624309	0.230034014110581	no	1134	0.245451719294819	820	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L23A; homologous to mammalian ribosomal protein L23 and bacterial L14; RPL23A has a paralog, RPL23B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YMR144W_p	YMR144W	YMR144W	hom	Uncharacterized	0.735392608663945	0.231050211009338	no	1135	0.225881937908635	747	NA	FT		NUCLEUS		Putative protein of unknown function; localized to the nucleus; YMR144W is not an essential gene	biological_process	molecular_function	nucleus
YJR115W_p	YJR115W	YJR115W	hom	Uncharacterized	0.735086170976661	0.231143507959183	no	1136	0.210463349574668	692	NA					Putative protein of unknown function; YJR115W has a paralog, ECM13, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YLL018C-A	YLL018C-A	COX19	hom	Verified	0.734894268363815	0.231201944662458	no	1137	0.247548244253175	878	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS	MITOCHONDRION		Protein required for cytochrome c oxidase assembly, located in the cytosol and mitochondrial intermembrane space; putative copper metallochaperone that delivers copper to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs	mitochondrial respiratory chain complex IV assembly|metal ion transport	copper ion binding|copper chaperone activity	cytosol|mitochondrial intermembrane space
YKL159C	YKL159C	RCN1	hom	Verified	0.73359561672056	0.231597616598781	no	1138	0.22234117583745	753	NA	FT	SIGNALING			Protein involved in calcineurin regulation during calcium signaling; has similarity to H. sapiens DSCR1 which is found in the Down Syndrome candidate region	calcium-mediated signaling	protein phosphatase 2B binding|calcium-dependent protein serine/threonine phosphatase regulator activity	cytoplasm
YBR093C	YBR093C	PHO5	hom	Verified	0.73293971629397	0.231797599068605	no	1139	0.221003756226301	761	NA	FT	RESPONSE TO NUTRIENT LEVELS			Repressible acid phosphatase (1 of 3) that also mediates extracellular nucleotide-derived phosphate hydrolysis; secretory pathway derived cell surface glycoprotein; induced by phosphate starvation and coordinately regulated by PHO4 and PHO2	cellular response to phosphate starvation|phosphate-containing compound metabolic process|regulation of cell size	nucleoside-triphosphate diphosphatase activity|nucleoside-triphosphatase activity|acid phosphatase activity	fungal-type cell wall|cell wall-bounded periplasmic space
YPL058C	YPL058C	PDR12	hom	Verified	0.731512277801716	0.232233153957523	no	1140	0.233581642880499	788	NA	FT	KETONE METABOLISM|NUCLEOTIDE METABOLISM	PLASMA MEMBRANE		Plasma membrane ATP-binding cassette (ABC) transporter, weak-acid-inducible multidrug transporter required for weak organic acid resistance; induced by sorbate and benzoate and regulated by War1p; mutants exhibit sorbate hypersensitivity	propionate metabolic process|transport|organic acid transport	xenobiotic-transporting ATPase activity|organic acid transmembrane transporter activity	integral to membrane|plasma membrane
YLR460C_p	YLR460C	YLR460C	hom	Uncharacterized	0.730797304893291	0.23245148499774	no	1141	0.214220456557129	741	NA	FT	OXIDATION-REDUCTION PROCESS			Member of the quinone oxidoreductase family, up-regulated in response to the fungicide mancozeb; possibly up-regulated by iodine	biological_process	molecular_function	cellular_component
YHR076W	YHR076W	PTC7	hom	Verified	0.730606503004646	0.2325097693984	no	1142	0.249302600944883	835	NA	FT		ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION		Type 2C protein phosphatase (PP2C); alternatively spliced to create two mRNA isoforms; protein from spliced form localizes to the mitochondria while the one from the unspliced form is localized to the nuclear envelope	biological_process	protein serine/threonine phosphatase activity	nuclear envelope|mitochondrion
YOR227W	YOR227W	HER1	hom	Verified	0.730492278993205	0.232544665383871	no	1143	0.240966499106244	828	NA	FT		MITOCHONDRION		Protein of unknown function required for proliferation or remodeling of the ER that is caused by overexpression of Hmg2p; may interact with ribosomes, based on co-purification experiments; HER1 has a paralog, GIP3, that arose from the whole genome duplication	endoplasmic reticulum organization	molecular_function	mitochondrion|ribosome|cytoplasm
YCR046C	YCR046C	IMG1	hom	Verified	0.727947027599263	0.233323006898499	no	1144	0.237614919528006	802	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit, required for respiration and for maintenance of the mitochondrial genome	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YPL065W	YPL065W	VPS28	hom	Verified	0.727860025836326	0.233349637688804	no	1145	0.254422968481798	905	NA	FF|FT	PROTEIN LOCALIZATION|PROTEOLYSIS|VACUOLAR TRANSPORT			Component of the ESCRT-I complex (Stp22p, Srn2p, Vps28p, and Mvb12p), which is involved in ubiquitin-dependent sorting of proteins into the endosome; conserved C-terminal domain interacts with ESCRT-III subunit Vps20p	protein targeting to membrane|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|protein targeting to vacuole	protein complex binding	endosome|ESCRT I complex
YNL236W	YNL236W	SIN4	hom	Verified	0.726148336725514	0.233873919745426	no	1146	0.274576078773763	951	NA	FF|FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS	RNA POL II, HOLOENZYME	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; contributes to both postive and negative transcriptional regulation; dispensible for basal transcription	negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II transcriptional preinitiation complex assembly|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II activating transcription factor binding	core mediator complex
YPL180W	YPL180W	TCO89	hom	Verified	0.724999262188373	0.234226241529946	no	1147	0.254153860655608	897	NA	FT	SIGNALING|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	PLASMA MEMBRANE		Subunit of TORC1 (Tor1p or Tor2p-Kog1p-Lst8p-Tco89p), a complex that regulates growth in response to nutrient availability; cooperates with Ssd1p in the maintenance of cellular integrity; deletion strains are hypersensitive to rapamycin	TOR signaling cascade|fungal-type cell wall organization|response to salt stress|regulation of cell growth|glycerol metabolic process	molecular_function	TORC1 complex|fungal-type vacuole membrane|extrinsic to internal side of plasma membrane|extrinsic to vacuolar membrane
YGR146C-A_p	YGR146C-A	YGR146C-A	hom	Uncharacterized	0.724804318291887	0.234286043103255	no	1148	0.229955980278703	753	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YPR106W	YPR106W	ISR1	hom	Verified	0.724299426061842	0.234440964636973	no	1149	0.228726808268332	774	NA	FT	PROTEIN PHOSPHORYLATION			Predicted protein kinase, overexpression causes sensitivity to staurosporine, which is a potent inhibitor of protein kinase C	biological_process	protein kinase activity	cellular_component
YOR059C	YOR059C	YOR059C	hom	Verified	0.721157165080406	0.235406411488983	no	1150	0.215522020454647	773	NA	FT	LIPID METABOLISM			Lipid particle protein of unknown function; contains a putative lipase serine active site; induced by transcription factor Rpn4p; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	lipid particle
YDR506C	YDR506C	GMC1	hom	Verified	0.720163920481669	0.23571203763036	no	1151	0.220572291157302	731	NA	FT	CELL CYCLE|ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS			Protein involved in meiotic progression; mutants are delayed in meiotic nuclear division and are defective in synaptonemal complex assembly; possible membrane-localized protein	meiosis|synaptonemal complex organization	molecular_function	cellular_component
YCR024C-A	YCR024C-A	PMP1	hom	Verified	0.719870657632095	0.235802317844255	no	1152	0.261498012434326	886	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Regulatory subunit for the plasma membrane H(+)-ATPase Pma1p; small single-membrane span proteolipid; forms unique helix and positively charged cytoplasmic domain that is able to specifically segregate phosphatidylserines; PMP1 has a paralog, PMP2, that arose from the whole genome duplication	cation transport	enzyme regulator activity	plasma membrane|membrane
YHR096C	YHR096C	HXT5	hom	Verified	0.716193214301493	0.236936026241449	no	1153	0.254721118210628	844	NA	FT		PLASMA MEMBRANE		Hexose transporter with moderate affinity for glucose; induced in the presence of non-fermentable carbon sources, induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs; HXT5 has a paralog, HXT3, that arose from the whole genome duplication	glucose transport|hexose transport	mannose transmembrane transporter activity|fructose transmembrane transporter activity|glucose transmembrane transporter activity	integral to membrane|plasma membrane
YLR273C	YLR273C	PIG1	hom	Verified	0.715566178318993	0.237129631922049	no	1154	0.200133103565752	672	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY			Putative targeting subunit for the type-1 protein phosphatase Glc7p that tethers it to the Gsy2p glycogen synthase	regulation of glycogen biosynthetic process	protein phosphatase type 1 regulator activity	protein phosphatase type 1 complex
YGR008C	YGR008C	STF2	hom	Verified	0.715538129889953	0.237138294277251	no	1155	0.237155574479395	799	NA	FT		MITOCHONDRION		Protein involved in resistance to dessication stress; Stf2p exhibits antioxidant properties, and its overexpression prevents ROS accumulation and apoptosis; binds to the F0 sector of mitochondrial F1F0 ATPase in vitro and is proposed to modulate the inhibitory action of Inh1p and Stf1p; protein abundance increases in response to DNA replication stress	cellular response to desiccation	molecular_function	cytoplasm
YKR089C	YKR089C	TGL4	hom	Verified	0.7130671937473	0.237902089376732	no	1156	0.236355417439457	807	NA	FT	LIPID METABOLISM|CELL DIVISION			Multifunctional triacylglycerol lipase, steryl ester hydrolase, and Ca2+-independent phospholipase A2; catalyzes acyl-CoA dependent acylation of LPA to PA; required with Tgl3p for timely bud formation; phosphorylated and activated by Cdc28p	phospholipid metabolic process|triglyceride catabolic process|triglyceride mobilization|cell budding	lysophosphatidic acid acyltransferase activity|triglyceride lipase activity|calcium-independent phospholipase A2 activity|sterol esterase activity	lipid particle
YER135C_d	YER135C	YER135C	hom	Dubious	0.711116025778718	0.238506169950162	no	1157	0.248784146242217	810	NA					Dubious open reading frame unlikely to encode a protein; YER135C is not an essential gene	Unknown	Unknown	Unknown
YJR052W	YJR052W	RAD7	hom	Verified	0.710997303007355	0.238542953539336	no	1158	0.236984305245317	802	NA	FT	RESPONSE TO DNA DAMAGE|PROTEOLYSIS	NUCLEUS	UBIQUITIN LIGASE COMPLEX	Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad16p) during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex	nucleotide-excision repair, DNA damage recognition|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	damaged DNA binding|ubiquitin-protein ligase activity|DNA-dependent ATPase activity	nucleotide-excision repair factor 4 complex|Cul3-RING ubiquitin ligase complex
YKL044W_p	YKL044W	YKL044W	hom	Uncharacterized	0.71001979515189	0.238845930442685	no	1159	0.219467448303152	737	NA					Protein of unknown function; mRNA identified as translated by ribosome profiling data	biological_process	molecular_function	cellular_component
YLR077W	YLR077W	FMP25	hom	Verified	0.709467200001631	0.239017299451974	no	1160	0.24589625733587	846	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial inner membrane protein required for an early step in assembly of respiratory complex III (cytochrome bc1 complex); mRNA is targeted to mitochondria	mitochondrial respiratory chain complex III assembly	molecular_function	mitochondrion|integral to mitochondrial inner membrane
YDR463W	YDR463W	STP1	hom	Verified	0.70923702230086	0.239088701237725	no	1161	0.336294739874483	1091	NA	FT	TRANSCRIPTION FROM RNA POL II|RNA PROCESSING	NUCLEUS|PLASMA MEMBRANE		Transcription factor; undergoes proteolytic processing by SPS (Ssy1p-Ptr3p-Ssy5p)-sensor component Ssy5p in response to extracellular amino acids; activates transcription of amino acid permease genes and may have a role in tRNA processing; STP1 has a paralog, STP2, that arose from the whole genome duplication	positive regulation of transcription, DNA-dependent|tRNA splicing, via endonucleolytic cleavage and ligation|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	plasma membrane|nucleus|cytoplasm
YNL297C	YNL297C	MON2	hom	Verified	0.709231202423771	0.239090506731469	no	1162	0.278578054613549	925	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Peripheral membrane protein with a role in endocytosis and vacuole integrity, interacts with Arl1p and localizes to the endosome; member of the Sec7p family of proteins	transport|endocytosis|protein targeting to vacuole|Golgi to endosome transport	guanyl-nucleotide exchange factor activity	cytosol|endosome|trans-Golgi network|extrinsic to membrane
YCR094W	YCR094W	CDC50	hom	Verified	0.706923663816289	0.239806958713816	no	1163	0.286928023236795	1004	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION	GOLGI APPARATUS		Endosomal protein that interacts with phospholipid flippase Drs2p; interaction with Cdc50p is essential for Drs2p catalytic activity; mutations affect cell polarity and polarized growth; similar to Lem3p; CDC50 has a paralog, YNR048W, that arose from the whole genome duplication	intracellular protein transport|phospholipid translocation|endocytosis|actin cortical patch localization	phospholipid-translocating ATPase activity	trans-Golgi network|late endosome membrane
YML089C_d	YML089C	YML089C	hom	Dubious	0.70506014188842	0.240386404784508	no	1164	0.226293182342352	722	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; expression induced by calcium shortage	Unknown	Unknown	Unknown
YDR348C	YDR348C	PAL1	hom	Verified	0.704761173325767	0.240479437422111	no	1165	0.242667464171249	840	NA	FT		SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Protein of unknown function thought to be involved in endocytosis; Pal1p physically interacts with Ede1p and is found at endocytic sites at the cell periphery during the early stages of endocytosis; green fluorescent protein (GFP)-fusion protein also localizes to the bud neck; potential Cdc28p substrate; similar to the S. pombe Pal1 protein; relocalizes from bud neck to cytoplasm upon DNA replication stress	biological_process	molecular_function	cell cortex|cellular bud neck|mating projection tip
YBR296C	YBR296C	PHO89	hom	Verified	0.704414922945137	0.240587207652273	no	1166	0.25493687495451	874	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Na+/Pi cotransporter, active in early growth phase; similar to phosphate transporters of Neurospora crassa; transcription regulated by inorganic phosphate concentrations and Pho4p; mutations in related human transporter genes hPit1 and hPit2 are associated with hyperphosphatemia-induced calcification of vascular tissue and familial idiopathic basal ganglia calcification	phosphate ion transport|transmembrane transport	sodium:inorganic phosphate symporter activity	integral to membrane|plasma membrane
YOR123C	YOR123C	LEO1	hom	Verified	0.704040140603242	0.240703888066072	no	1167	0.245609694917212	846	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE	NUCLEUS	RNA POL II, HOLOENZYME	Component of the Paf1 complex; which associates with RNA polymerase II and is involved in histone methylation; plays a role in regulating Ty1 transposition; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay	chromatin organization|Unknown|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription-coupled nucleotide-excision repair|histone H3-K4 trimethylation|transcription elongation from RNA polymerase II promoter	RNA binding|RNA polymerase II transcription factor binding transcription factor activity	nucleus|Cdc73/Paf1 complex
YLR247C	YLR247C	IRC20	hom	Verified	0.699891929397769	0.24199739897008	no	1168	0.21435358577845	740	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS|MITOCHONDRION		Putative helicase; localizes to the mitochondrion and the nucleus; YLR247C is not an essential gene; null mutant displays increased levels of spontaneous Rad52p foci	double-strand break repair via synthesis-dependent strand annealing	helicase activity	mitochondrion|nucleus
YGR118W	YGR118W	RPS23A	hom	Verified	0.699652638991868	0.242072130249807	no	1169	0.251290170567059	860	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit, required for translational accuracy; homologous to mammalian ribosomal protein S23 and bacterial S12; RPS23A has a paralog, RPS23B, that arose from the whole genome duplication; deletion of both RPS23A and RPS23B is lethal	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|regulation of translational fidelity	structural constituent of ribosome	cytosolic small ribosomal subunit
YER170W	YER170W	ADK2	hom	Verified	0.699054929515063	0.24225885178914	no	1170	0.243056645238054	865	NA	FT	NUCLEOTIDE METABOLISM	MITOCHONDRION		Mitochondrial adenylate kinase, catalyzes the reversible synthesis of GTP and AMP from GDP and ADP; may serve as a back-up for synthesizing GTP or ADP depending on metabolic conditions; 3' sequence of ADK2 varies with strain background	nucleotide metabolic process	nucleoside triphosphate adenylate kinase activity|adenylate kinase activity	mitochondrion|mitochondrial inner membrane
YGL244W	YGL244W	RTF1	hom	Verified	0.698106028129674	0.242555444242	no	1171	0.298618986189734	1041	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION|GENE SILENCING	NUCLEUS|CHROMOSOME	RNA POL II, HOLOENZYME	Subunit of RNAPII-associated chromatin remodeling Paf1 complex; regulates gene expression by directing cotranscriptional histone modification, influences transcription and chromatin structure through several independent functional domains; directly or indirectly regulates DNA-binding properties of Spt15p and relative activities of different TATA elements; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay	mRNA 3'-end processing|snoRNA transcription from an RNA polymerase II promoter|regulation of chromatin silencing at telomere|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|regulation of histone H3-K4 methylation|regulation of transcription-coupled nucleotide-excision repair|negative regulation of transcription from RNA polymerase II promoter|recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex|global genome nucleotide-excision repair|snoRNA 3'-end processing|Unknown|transcription elongation from RNA polymerase II promoter	RNA binding|RNA polymerase II transcription factor binding transcription factor activity	nucleus|transcriptionally active chromatin|Cdc73/Paf1 complex
YCL016C	YCL016C	DCC1	hom	Verified	0.694800569804477	0.243590145529074	no	1172	0.263080739694165	905	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION	CHROMOSOME		Subunit of a complex with Ctf8p and Ctf18p that shares some components with Replication Factor C, required for sister chromatid cohesion and telomere length maintenance	maintenance of DNA trinucleotide repeats|response to DNA damage stimulus|mitotic sister chromatid cohesion	molecular_function	Ctf18 RFC-like complex
YOR346W	YOR346W	REV1	hom	Verified	0.694296696992379	0.243748080984328	no	1173	0.219330096097727	709	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS|MITOCHONDRION|CHROMOSOME		Deoxycytidyl transferase; involved in repair of abasic sites and adducted guanines in damaged DNA by translesion synthesis (TLS); forms a complex with the subunits of DNA polymerase zeta, Rev3p and Rev7p; relocalizes from nucleus to cytoplasm upon DNA replication stress	error-prone translesion synthesis|error-free translesion synthesis	deoxycytidyl transferase activity|DNA-directed DNA polymerase activity	nuclear chromatin|mitochondrion|replication fork
YOR003W	YOR003W	YSP3	hom	Verified	0.694181791420536	0.243784105081451	no	1174	0.227978124955006	771	NA	FT	PROTEOLYSIS			Putative precursor to the subtilisin-like protease III	protein catabolic process	peptidase activity	cellular_component
YGR284C	YGR284C	ERV29	hom	Verified	0.693789266441743	0.24390718743615	no	1175	0.250076088224168	845	NA	FT	VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein localized to COPII-coated vesicles; involved in vesicle formation and incorporation of specific secretory cargo; protein abundance increases in response to DNA replication stress	ER to Golgi vesicle-mediated transport	molecular_function	integral to membrane|ER to Golgi transport vesicle
YLR210W	YLR210W	CLB4	hom	Verified	0.692210956111233	0.244402429657259	no	1176	0.242676486485191	821	NA	FT	CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION	NUCLEUS|CYTOSKELETON		B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation	G2/M transition of mitotic cell cycle|S phase of mitotic cell cycle|regulation of cyclin-dependent protein kinase activity|positive regulation of spindle pole body separation	cyclin-dependent protein kinase regulator activity	nucleus|spindle pole body|cytoplasm
YPR093C	YPR093C	ASR1	hom	Verified	0.692200064503041	0.244405849107653	no	1177	0.243142901929327	825	NA	FT		NUCLEUS		Ubiquitin ligase that modifies and regulates RNA Pol II; involved in a putative alcohol-responsive signaling pathway; accumulates in the nucleus under alcohol stress; contains a Ring/PHD finger domain similar to the mammalian rA9 protein	response to ethanol|protein ubiquitination	ubiquitin-protein ligase activity	nucleus|cytoplasm
YGR262C	YGR262C	BUD32	hom	Verified	0.69219242060097	0.24440824894716	no	1178	0.287998935470194	950	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|LIPID METABOLISM|CELL DIVISION|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION	NUCLEUS|CHROMOSOME		Protein kinase, component of the EKC/KEOPS complex with Kae1p, Cgi121p, Pcc1p, and Gon7p; EKC/KEOPS complex is required for t6A tRNA modification and may have roles in telomere maintenance and transcription	threonylcarbamoyladenosine metabolic process|protein phosphorylation|telomere maintenance|cellular bud site selection|positive regulation of transcription from RNA polymerase II promoter	protein serine/threonine kinase activity	EKC/KEOPS complex|nucleus|cytoplasm
YMR013W-A_d	YMR013W-A	YMR013W-A	hom	Dubious	0.689927841313558	0.245119783214482	no	1179	0.23108890716522	758	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the characterized snoRNA gene snR73	Unknown	Unknown	Unknown
YDR513W	YDR513W	GRX2	hom	Verified	0.687763638499495	0.245800818755992	no	1180	0.229501242161418	755	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|RESPONSE TO OXIDATIVE STRESS	MITOCHONDRION		Cytoplasmic glutaredoxin; thioltransferase, glutathione-dependent disulfide oxidoreductase involved in maintaining redox state of target proteins, also exhibits glutathione peroxidase activity, expression induced in response to stress; GRX2 has a paralog, GRX1, that arose from the whole genome duplication	cellular response to oxidative stress	disulfide oxidoreductase activity|glutathione transferase activity|glutathione peroxidase activity	cytosol|mitochondrion
YKR055W	YKR055W	RHO4	hom	Verified	0.687375778903745	0.245922978408805	no	1181	0.237552969494007	853	NA	FT	SIGNALING|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely to be involved in the establishment of cell polarity	positive regulation of formin-nucleated actin cable assembly|maintenance of cell polarity|regulation of formin-nucleated actin cable assembly	GTPase activity	incipient cellular bud site|plasma membrane|cellular bud neck
YKL075C_p	YKL075C	YKL075C	hom	Uncharacterized	0.686729830601494	0.246126497568739	no	1182	0.256094149218549	871	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; proposed to be involved in resistance to streptozotocin and camptothecin	response to drug	molecular_function	cytoplasm
YMR193C-A_d	YMR193C-A	YMR193C-A	hom	Dubious	0.686223496587542	0.246286091540672	no	1183	0.218495856585002	732	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YEL038W	YEL038W	UTR4	hom	Verified	0.68486491592607	0.246714583425441	no	1184	0.205369013394124	697	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Protein with sequence similarity to 2,3-diketo-5-methylthiopentyl-1-phosphate enolase-phosphatases, involved in methionine salvage; found in both the cytoplasm and nucleus	L-methionine salvage from methylthioadenosine	acireductone synthase activity	nucleus|cytoplasm
YOL153C	YOL153C	YOL153C	hom	pseudogene	0.684487881387389	0.246833569608307	no	1185	0.21308411028011	707	NA					Hypothetical protein	biological_process	molecular_function	cellular_component
YDR266C	YDR266C	HEL2	hom	Verified	0.683541619961003	0.247132330104848	no	1186	0.254085055984609	839	NA					RING finger ubiquitin ligase (E3); involved in ubiquitylation and degradation of excess histones; interacts with Ubc4p and Rad53p; null mutant sensitive to hydroxyurea (HU); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; computational analysis suggests a role as a transcription factor	biological_process	molecular_function	ribosome|cytoplasm
YBR231C	YBR231C	SWC5	hom	Verified	0.680497118078726	0.248094873000111	no	1187	0.280758777669493	975	NA	FF|FT	CHROMATIN ORGANIZATION	NUCLEUS|CHROMOSOME		Component of the SWR1 complex; complex exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; protein abundance increases in response to DNA replication stress	chromatin remodeling|histone exchange	molecular_function	Swr1 complex|nucleus
YIL050W	YIL050W	PCL7	hom	Verified	0.679417597361972	0.248436651503851	no	1188	0.192090555963623	664	NA	FT	CELL CYCLE|OXIDATION-REDUCTION PROCESS|CELL DIVISION|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS		Pho85p cyclin of the Pho80p subfamily, forms a functional kinase complex with Pho85p which phosphorylates Mmr1p and is regulated by Pho81p; involved in glycogen metabolism, expression is cell-cycle regulated	regulation of glycogen catabolic process|regulation of cyclin-dependent protein kinase activity|regulation of protein stability|regulation of glycogen biosynthetic process	cyclin-dependent protein kinase regulator activity	cyclin-dependent protein kinase holoenzyme complex|nucleus
YBR008C	YBR008C	FLR1	hom	Verified	0.679000645265945	0.248568726549044	no	1189	0.230091314484557	798	NA	FT		PLASMA MEMBRANE		Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; involved in efflux of fluconazole, diazaborine, benomyl, methotrexate, and other drugs; expression induced in cells treated with the mycotoxin patulin; relocalizes from nucleus to plasma membrane upon DNA replication stress	drug transmembrane transport|transmembrane transport	fluconazole transporter activity|drug transmembrane transporter activity	integral to membrane|plasma membrane
YGL246C	YGL246C	RAI1	hom	Verified	0.676810692594764	0.249263036531969	no	1190	0.245643888647004	825	NA	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Nuclear protein with decapping endonuclease activity targeted toward mRNAs with unmethylated 7-methylguanosine cap structures; binds to and stabilizes the exoribonuclease Rat1p; required for pre-rRNA processing; homologous to human DOM3Z	deadenylation-dependent decapping of nuclear-transcribed mRNA|maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|termination of RNA polymerase II transcription, poly(A)-coupled|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	enzyme regulator activity|m7G(5')pppN diphosphatase activity	nucleus
YGR072W	YGR072W	UPF3	hom	Verified	0.676314281539213	0.249420563612964	no	1191	0.238399807381884	806	NA	FT		NUCLEUS		Component of the nonsense-mediated mRNA decay (NMD) pathway, along with Nam7p and Nmd2p; involved in decay of mRNA containing nonsense codons; involved in telomere maintenance	nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay|translational frameshifting|protein ubiquitination	molecular_function	nucleolus|nucleus|polysome|cytoplasm
YGL175C	YGL175C	SAE2	hom	Verified	0.675689068279495	0.249619039006974	no	1192	0.231459533692535	797	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS		Endonuclease that processes hairpin DNA structures with the MRX complex; involved in meiotic and mitotic double-strand break repair; phosphorylated in response to DNA damage and required for normal resistance to DNA-damaging agents	DNA double-strand break processing|DNA catabolic process, endonucleolytic|meiotic DNA double-strand break formation|meiotic DNA double-strand break processing|gene conversion at mating-type locus, DNA double-strand break processing	double-stranded DNA binding|single-stranded DNA specific endodeoxyribonuclease activity	nucleus|cytoplasm
YNL176C_p	YNL176C	TDA7	hom	Uncharacterized	0.675271285318763	0.249751711919281	no	1193	0.250483981876525	823	NA					Cell cycle-regulated gene of unknown function, promoter bound by Fkh2p; null mutant is sensitive to expression of the top1-T722A allele	biological_process	molecular_function	fungal-type vacuole
YBR089C-A	YBR089C-A	NHP6B	hom	Verified	0.674490759476595	0.249999679274407	no	1194	0.22122035919841	733	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		High-mobility group (HMG) protein, binds to and remodels nucleosomes; involved in recruiting FACT and other chromatin remodelling complexes to the chromosomes; functionally redundant with Nhp6Ap; homologous to mammalian HMGB1 and HMGB2; NHP6B has a paralog, NHP6A, that arose from the whole genome duplication	RNA polymerase III transcriptional preinitiation complex assembly|chromatin remodeling|transcription from RNA polymerase II promoter	nucleosome binding|DNA binding, bending|sequence-specific DNA binding	nucleus
YIL108W	YIL108W	YIL108W	hom	Verified	0.674276075564218	0.250067905684878	no	1195	0.217144103751197	719	NA	FT	PROTEOLYSIS			Putative metalloendopeptidase; forms cytoplasmic foci upon DNA replication stress	biological_process	molecular_function	cytoplasm
YCL028W	YCL028W	RNQ1	hom	Verified	0.673565757842097	0.250293714597042	no	1196	0.230419280062273	827	NA	FT		NUCLEUS		[PIN(+)] prion, an infectious protein conformation that is generally an ordered protein aggregate	biological_process	molecular_function	cytosol
YKL213C	YKL213C	DOA1	hom	Verified	0.672354303035972	0.250679083500976	no	1197	0.235011593005761	797	NA	FT	RESPONSE TO DNA DAMAGE|PROTEOLYSIS	NUCLEUS		WD repeat protein required for ubiquitin-mediated protein degradation; forms a complex with Cdc48p; plays a role in controlling cellular ubiquitin concentration; also promotes efficient NHEJ in postdiauxic/stationary phase; protein increases in abundance and relocalizes from nucleus to nuclear periphery upon DNA replication stress	double-strand break repair via nonhomologous end joining|ubiquitin-dependent protein catabolic process	ubiquitin binding	nucleus|cytoplasm
YBR163W	YBR163W	EXO5	hom	Verified	0.672272065404981	0.25070525502507	no	1198	0.252355861026522	898	NA	FT	MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial 5'-3' exonuclease and sliding exonuclease, required for mitochondrial genome maintenance; distantly related to the RecB nuclease domain of bacterial RecBCD recombinases; may be regulated by the transcription factor Ace2	mitochondrial genome maintenance	single-stranded DNA specific 5'-3' exodeoxyribonuclease activity	mitochondrion
YFR034C	YFR034C	PHO4	hom	Verified	0.67135956796499	0.250995747735254	no	1199	0.284620967995875	999	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Basic helix-loop-helix (bHLH) transcription factor of the myc-family; activates transcription cooperatively with Pho2p in response to phosphate limitation; binding to 'CACGTG' motif is regulated by chromatin restriction, competitive binding of Cbf1p to the same DNA binding motif and cooperation with Pho2p,; function is regulated by phosphorylation at multiple sites and by phosphate availability	cellular response to phosphate starvation|positive regulation of phosphate metabolic process|phosphate-containing compound metabolic process|chromatin remodeling|positive regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	nucleus|cytoplasm
YNL022C_p	YNL022C	YNL022C	hom	Uncharacterized	0.670623925930107	0.251230068303343	no	1200	0.23624586259245	840	NA	FT		NUCLEUS		Putative cytosine 5-methyltransferase, contains seven beta-strand methyltransferase motif similar to NOP2/YNL061W; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; predicted to be involved in ribosome biogenesis	biological_process	tRNA (cytosine-5-)-methyltransferase activity	nucleus
YIL125W	YIL125W	KGD1	hom	Verified	0.670046382260753	0.251414111575955	no	1201	0.265501840067408	901	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes a key step in the tricarboxylic acid (TCA) cycle, the oxidative decarboxylation of alpha-ketoglutarate to form succinyl-CoA	tricarboxylic acid cycle|2-oxoglutarate metabolic process	oxoglutarate dehydrogenase (succinyl-transferring) activity	mitochondrial nucleoid|mitochondrion|mitochondrial matrix|mitochondrial oxoglutarate dehydrogenase complex
YKR040C_d	YKR040C	YKR040C	hom	Dubious	0.669864343129369	0.25147213594299	no	1202	0.243825602369975	840	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YKR041W	Unknown	Unknown	Unknown
YLR280C_d	YLR280C	YLR280C	hom	Dubious	0.669579547722456	0.251562927724984	no	1203	0.221884788266173	722	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YKL167C	YKL167C	MRP49	hom	Verified	0.668943169466908	0.251765865458877	no	1204	0.254600880217054	879	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit, not essential for mitochondrial translation	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YMR186W	YMR186W	HSC82	hom	Verified	0.667705226550486	0.252160886549441	no	1205	0.254584402109809	862	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS	MITOCHONDRION		Cytoplasmic chaperone of the Hsp90 family; redundant in function and nearly identical with Hsp82p, and together they are essential; expressed constitutively at 10-fold higher basal levels than HSP82 and induced 2-3 fold by heat shock; contains two acid-rich unstructured regions that promote the solubility of chaperone-substrate complexes; HSC82 has a paralog, HSP82, that arose from the whole genome duplication	protein folding|proteasome assembly|protein refolding|telomere maintenance|'de novo' protein folding|box C/D snoRNP assembly|response to stress	unfolded protein binding|ATPase activity, coupled|ATPase activity	mitochondrion|plasma membrane|cytoplasm
YOL084W	YOL084W	PHM7	hom	Verified	0.667084143048039	0.252359194110187	no	1206	0.206364670754301	673	NA	FT		PLASMA MEMBRANE		Protein of unknown function; expression is regulated by phosphate levels; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	integral to membrane|fungal-type vacuole
YPL184C	YPL184C	MRN1	hom	Verified	0.666493288199618	0.252547926153147	no	1207	0.254754628369559	910	NA	FT	TRANSLATION			RNA-binding protein that may be involved in translational regulation; binds specific categories of mRNAs, including those that contain upstream open reading frames (uORFs) and internal ribosome entry sites (IRES); interacts genetically with chromatin remodelers and splicing factors, linking chromatin state, splicing and as a result mRNA maturation	biological_process	molecular_function	cytoplasm
YMR164C	YMR164C	MSS11	hom	Verified	0.666257295924862	0.252623328056716	no	1208	0.251576853816441	845	NA	FT	TRANSCRIPTION FROM RNA POL II|CARBOHYDRATE METABOLISM	NUCLEUS		Transcription factor involved in regulation of invasive growth and starch degradation; controls the activation of FLO11 and STA2 in response to nutritional signals	biofilm formation|Unknown|positive regulation of starch catabolic process by positive regulation of transcription from RNA polymerase II promoter|positive regulation of invasive growth in response to glucose limitation by positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YER084W_p	YER084W	YER084W	hom	Uncharacterized	0.666044619444276	0.25269129048703	no	1209	0.261220936314251	909	NA					Protein of unknown function; expressed at both mRNA and protein levels	biological_process	molecular_function	cellular_component
YBR204C	YBR204C	LDH1	hom	Verified	0.665720927235624	0.25279474733743	no	1210	0.248540747164676	830	NA	FT	LIPID METABOLISM			Serine hydrolase; exhibits active esterase plus weak triacylglycerol lipase activities; proposed role in lipid homeostasis, regulating phospholipid and non-polar lipid levels and required for mobilization of LD-stored lipids; localizes to the lipid droplet (LD) surface; contains a classical serine containing catalytic triad (GxSxG motif)	lipid homeostasis	hydrolase activity, acting on ester bonds|serine hydrolase activity|triglyceride lipase activity	lipid particle
YNR032W	YNR032W	PPG1	hom	Verified	0.663716442475713	0.253435906825601	no	1211	0.252873257034481	847	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS		Putative serine/threonine protein phosphatase of the type 2A-like phosphatase family, required for glycogen accumulation; interacts with Tap42p, which binds to and regulates other protein phosphatases	glycogen metabolic process|protein dephosphorylation	protein serine/threonine phosphatase activity	nucleus|cytoplasm
YJL058C	YJL058C	BIT61	hom	Verified	0.663200056982938	0.25360121750379	no	1212	0.236924246717072	797	NA	FT	SIGNALING|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION	PLASMA MEMBRANE		Subunit of TORC2 membrane-associated complex; involved in regulation of cell cycle-dependent actin cytoskeletal dynamics during polarized growth and cell wall integrity; BIT61 has a paralog, BIT2, that arose from the whole genome duplication	fungal-type cell wall organization|TOR signaling cascade|regulation of cell growth|establishment or maintenance of actin cytoskeleton polarity	molecular_function	TORC2 complex|plasma membrane|cytoplasm
YHL009C	YHL009C	YAP3	hom	Verified	0.661558091697521	0.254127236608504	no	1213	0.26672053058124	911	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Basic leucine zipper (bZIP) transcription factor	regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	nucleus
YNR040W_p	YNR040W	YNR040W	hom	Uncharacterized	0.660112674996643	0.254590762687647	no	1214	0.261002147050967	882	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YNL071W	YNL071W	LAT1	hom	Verified	0.659829853621528	0.254681511550732	no	1215	0.276124803707236	916	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Dihydrolipoamide acetyltransferase component (E2) of pyruvate dehydrogenase complex, which catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA	acetyl-CoA biosynthetic process from pyruvate	dihydrolipoyllysine-residue acetyltransferase activity	mitochondrion|mitochondrial pyruvate dehydrogenase complex
YIL128W	YIL128W	MET18	hom	Verified	0.659745037116332	0.254708729914681	no	1216	0.402219687882639	1318	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM|RESPONSE TO DNA DAMAGE	NUCLEUS		Component of cytosolic iron-sulfur protein assembly (CIA) machinery; acts at a late step of Fe-S cluster assembly; forms the CIA targeting complex with Cia1p and Cia2p that directs Fe-S cluster incorporation into a subset of proteins involved in methionine biosynthesis, DNA replication and repair, transcription, and telomere maintenance; ortholog of human MMS19	methionine metabolic process|nucleotide-excision repair|transcription from RNA polymerase II promoter	molecular_function	cytoplasm
YOR267C	YOR267C	HRK1	hom	Verified	0.658667578166218	0.255054628520498	no	1217	0.216353860178271	711	NA	FT	ION HOMEOSTASIS|PROTEIN PHOSPHORYLATION|ION HOMEOSTASIS			Protein kinase; implicated in activation of the plasma membrane H(+)-ATPase Pma1p in response to glucose metabolism; plays a role in ion homeostasis; protein abundance increases in response to DNA replication stress	protein phosphorylation|cellular ion homeostasis	protein serine/threonine kinase activity|protein kinase activity	cytoplasm
YJL181W_p	YJL181W	YJL181W	hom	Uncharacterized	0.658566793676499	0.255086996111346	no	1218	0.211824569992246	720	NA					Putative protein of unknown function; expression is cell-cycle regulated as shown by microarray analysis; potential regulatory target of Mbp1p, which binds to the YJL181W promoter region; YJL181W has a paralog, YJR030C, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YBR189W	YBR189W	RPS9B	hom	Verified	0.657666460141859	0.255376239349623	no	1219	0.248052576293856	843	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION	NUCLEUS	RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S9 and bacterial S4; RPS9B has a paralog, RPS9A, that arose from the whole genome duplication	positive regulation of translational fidelity|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome	small-subunit processome|cytosolic small ribosomal subunit|90S preribosome
YNR056C	YNR056C	BIO5	hom	Verified	0.65614625677045	0.255865012184916	no	1220	0.248389786294339	841	NA	FT	KETONE METABOLISM|COFACTOR METABOLISM	PLASMA MEMBRANE		Putative transmembrane protein involved in the biotin biosynthesis pathway; responsible for uptake of 7-keto 8-aminopelargonic acid; BIO5 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis	biotin biosynthetic process|vitamin transport	transmembrane transporter activity	integral to membrane|plasma membrane
YLR004C	YLR004C	THI73	hom	Verified	0.656086844276639	0.255884124282971	no	1221	0.233983119782688	786	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|PLASMA MEMBRANE		Putative plasma membrane permease proposed to be involved in carboxylic acid uptake and repressed by thiamine; substrate of Dbf2p/Mob1p kinase; transcription is altered if mitochondrial dysfunction occurs	transport	transporter activity	integral to membrane|endoplasmic reticulum
YBR175W	YBR175W	SWD3	hom	Verified	0.647134914178297	0.258772315238031	no	1222	0.254332000806577	870	NA	FT	CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS|CHROMOSOME		Essential subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member and ortholog of mammalian WDR5	histone H3-K4 methylation|telomere maintenance|chromatin silencing at telomere	histone methyltransferase activity (H3-K4 specific)	Set1C/COMPASS complex
YIL140W	YIL140W	AXL2	hom	Verified	0.645901184669124	0.259171676177353	no	1223	0.254766747858444	879	NA	FT	CELL CYCLE|CELL DIVISION	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON		Integral plasma membrane protein required for axial budding in haploid cells, localizes to the incipient bud site and bud neck; glycosylated by Pmt4p; potential Cdc28p substrate	axial cellular bud site selection|cellular bud site selection	molecular_function	integral to plasma membrane|cellular bud neck|septin ring
YAR015W	YAR015W	ADE1	hom	Verified	0.64426308882714	0.259702423307938	no	1224	0.256943235530265	892	NA	FT	NUCLEOTIDE METABOLISM	NUCLEUS		N-succinyl-5-aminoimidazole-4-carboxamide ribotide (SAICAR) synthetase, required for 'de novo' purine nucleotide biosynthesis; red pigment accumulates in mutant cells deprived of adenine; protein abundance increases in response to DNA replication stress	purine nucleotide biosynthetic process|'de novo' IMP biosynthetic process	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity	nucleus|cytoplasm
YHR021C	YHR021C	RPS27B	hom	Verified	0.643010846355688	0.260108530991833	no	1225	0.274449569184468	923	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S27, no bacterial homolog; RPS27B has a paralog, RPS27A, that arose from the whole genome duplication	cytoplasmic translation|ribosomal small subunit assembly|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome	cytosolic small ribosomal subunit
YGL037C	YGL037C	PNC1	hom	Verified	0.64173285675212	0.26052332587017	no	1226	0.236687653437484	804	NA	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|GENE SILENCING	NUCLEUS		Nicotinamidase that converts nicotinamide to nicotinic acid; part of the NAD(+) salvage pathway; required for life span extension by calorie restriction; PNC1 expression responds to all known stimuli that extend replicative life span; protein increases in abundance and relative distribution to cytoplasmic foci decreases upon DNA replication stress	replicative cell aging|chromatin silencing at rDNA|nicotinate nucleotide salvage|chromatin silencing at telomere	nicotinamidase activity	nucleus|peroxisome|cytoplasm
YER119C	YER119C	AVT6	hom	Verified	0.641561394156763	0.260579003090315	no	1227	0.249181452366268	857	NA	FT	VACUOLAR TRANSPORT			Vacuolar aspartate and glutamate exporter; member of a family of seven genes (AVT1-7) related to vesicular GABA-glycine transporters; involved in compartmentalizing acidic amino acids in response to nitrogen starvation; AVT6 has a paralog, AVT5, that arose from the whole genome duplication	amino acid export from vacuole|transmembrane transport	L-aspartate transmembrane transporter activity|transporter activity|L-glutamate transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane|fungal-type vacuole
YIL079C	YIL079C	AIR1	hom	Verified	0.641559629027846	0.260579576293658	no	1228	0.262007273538675	888	NA	FT	RNA PROCESSING	NUCLEUS		Zinc knuckle protein; involved in nuclear RNA processing and degradation as a component of the TRAMP complex; stimulates the poly(A) polymerase activity of Pap2p in vitro; AIR1 has a paralog, AIR2, that arose from the whole genome duplication	nuclear mRNA surveillance of mRNA 3'-end processing|nuclear polyadenylation-dependent tRNA catabolic process|nuclear polyadenylation-dependent CUT catabolic process|nuclear polyadenylation-dependent snoRNA catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|ncRNA polyadenylation|nuclear polyadenylation-dependent snRNA catabolic process	polynucleotide adenylyltransferase activity	nucleolus|TRAMP complex
YOR101W	YOR101W	RAS1	hom	Verified	0.640607699344468	0.260888797989643	no	1229	0.228772083856722	810	NA	FT	SIGNALING|NUCLEOTIDE METABOLISM	PLASMA MEMBRANE		GTPase involved in G-protein signaling in adenylate cyclase activation; plays a role in cell proliferation; localized to the plasma membrane; homolog of mammalian RAS proto-oncogenes; relative distribution to the nucleus increases upon DNA replication stress	adenylate cyclase-activating G-protein coupled receptor signaling pathway|replicative cell aging|Ras protein signal transduction	GTPase activity	plasma membrane
YGL067W	YGL067W	NPY1	hom	Verified	0.639768495130348	0.261161558764437	no	1230	0.207265023342798	654	NA	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM			NADH diphosphatase (pyrophosphatase), hydrolyzes the pyrophosphate linkage in NADH and related nucleotides; localizes to peroxisomes; nudix hydrolase family member	NADH metabolic process	NAD+ diphosphatase activity	peroxisome|cytoplasm
YDL039C	YDL039C	PRM7	hom	Verified	0.637277537919567	0.261972039708803	no	1231	0.25728176152858	844	NA					Pheromone-regulated protein, predicted to have one transmembrane segment; promoter contains Gcn4p binding elements	conjugation with cellular fusion	molecular_function	integral to membrane
YLR189C	YLR189C	ATG26	hom	Verified	0.635304417774235	0.262614946442429	no	1232	0.232642719071447	770	NA	FT	PROTEIN LOCALIZATION|LIPID METABOLISM|MEMBRANE ORGANIZATION|CARBOHYDRATE METABOLISM			UDP-glucose:sterol glucosyltransferase, conserved enzyme involved in synthesis of sterol glucoside membrane lipids; in contrast to ATG26 from P. pastoris, S. cerevisiae ATG26 is not involved in autophagy	sterol metabolic process|ascospore-type prospore membrane assembly	sterol 3-beta-glucosyltransferase activity	cytoplasm
YML053C_p	YML053C	YML053C	hom	Uncharacterized	0.635234121645688	0.26263786609357	no	1233	0.259152514015182	865	NA	FT		NUCLEUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; overexpression causes a cell cycle delay or arrest; YML053C is not an essential gene	biological_process	molecular_function	nucleus|cytoplasm
YDR346C	YDR346C	SVF1	hom	Verified	0.634653486851014	0.262827217885853	no	1234	0.289588743887122	996	NA	FT	RESPONSE TO OXIDATIVE STRESS	NUCLEUS		Protein with a potential role in cell survival pathways, required for the diauxic growth shift; expression in mammalian cells increases survival under conditions inducing apoptosis; mutant has increased aneuploidy tolerance	cellular response to oxidative stress	molecular_function	nucleus|cytoplasm
YBL104C	YBL104C	SEA4	hom	Verified	0.634042383605113	0.263026581174102	no	1235	0.355851851377353	1182	NA					Subunit of the SEA (Seh1-associated) complex, a coatomer-related complex that associates dynamically with the vacuole; has an N-terminal beta-propeller fold and a C-terminal RING motif; promoter contains multiple GCN4 binding sites	biological_process	molecular_function	Seh1-associated complex|extrinsic to fungal-type vacuolar membrane|cytoplasm
YDR522C	YDR522C	SPS2	hom	Verified	0.633287849318557	0.263272843278218	no	1236	0.241906048839636	847	NA	FT	CELL CYCLE|CELL WALL ORG/BIOGENESIS	PLASMA MEMBRANE		Protein expressed during sporulation; SPS2 has a paralog, SPS22, that arose from the whole genome duplication; redundant with Sps22p for organization of the beta-glucan layer of the spore wall; S. pombe ortholog is a spore wall component	ascospore wall assembly|ascospore formation	molecular_function	fungal-type cell wall|plasma membrane
YGR282C	YGR282C	BGL2	hom	Verified	0.631343193473899	0.263908075229435	no	1237	0.265079029013961	920	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM			Endo-beta-1,3-glucanase, major protein of the cell wall, involved in cell wall maintenance	fungal-type cell wall organization	1,3-beta-glucanosyltransferase activity|glucan endo-1,3-beta-D-glucosidase activity	fungal-type cell wall
YOL076W	YOL076W	MDM20	hom	Verified	0.630584618890548	0.264156079223448	no	1238	0.307121127395116	1062	NA	FF|FT	MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION			Non-catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes N-acetylation of proteins with specific N-terminal sequences; involved in mitochondrial inheritance and actin assembly	mitochondrion inheritance|N-terminal peptidyl-methionine acetylation|cytoskeleton organization	peptide alpha-N-acetyltransferase activity	NatB complex
YFL028C	YFL028C	CAF16	hom	Verified	0.629278598622932	0.264583339911086	no	1239	0.252871436715691	855	NA	FT	TRANSCRIPTION FROM RNA POL II|NUCLEOTIDE METABOLISM	NUCLEUS		Part of evolutionarily-conserved CCR4-NOT regulatory complex; contains single ABC-type ATPase domain but no transmembrane domain; interacts with several subunits of Mediator	regulation of transcription from RNA polymerase II promoter	ATPase activity	CCR4-NOT complex|cytoplasm
YDL130W-A	YDL130W-A	STF1	hom	Verified	0.627551225240085	0.26514898452972	no	1240	0.280407499170321	987	NA	FT	NUCLEOTIDE METABOLISM	MITOCHONDRION		Protein involved in regulation of the mitochondrial F1F0-ATP synthase; Stf1p and Stf2p act as stabilizing factors that enhance inhibitory action of the Inh1p protein; protein abundance increases in response to DNA replication stress	negative regulation of ATPase activity	molecular_function	mitochondrion|mitochondrial proton-transporting ATP synthase complex
YBL058W	YBL058W	SHP1	hom	Verified	0.627014765156434	0.265324778316028	no	1241	0.225558151532743	730	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|MEMBRANE ORGANIZATION|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|PROTEOLYSIS|CYTOSKELETON ORGANIZATION|RESPONSE TO NUTRIENT LEVELS|GEN. OF PRECURSOR METABOLITES AND ENERGY|CHROMOSOME SEGREGATION	NUCLEUS		UBX (ubiquitin regulatory X) domain-containing protein that regulates Glc7p phosphatase activity and interacts with Cdc48p; interacts with ubiquitylated proteins in vivo and is required for degradation of a ubiquitylated model substrate	glycogen metabolic process|proteasomal ubiquitin-dependent protein catabolic process|piecemeal microautophagy of nucleus|ER-associated protein catabolic process|ascospore formation|sister chromatid biorientation|autophagic vacuole assembly	protein phosphatase type 1 regulator activity	nucleus|cytoplasm
YGR243W	YGR243W	FMP43	hom	Verified	0.626894955085386	0.265364047222264	no	1242	0.264479136023746	953	NA	FT		MITOCHONDRION		Highly conserved subunit of the mitochondrial pyruvate carrier; a mitochondrial inner membrane complex comprised of Fmp37p/Mpc1p and either Mpc2p or Fmp43p/Mpc3p mediates mitochondrial pyruvate uptake; more highly expressed in glucose-containing minimal medium than in lactate-containing medium; expression regulated by osmotic and alkaline stresses; protein abundance increases in response to DNA replication stress	mitochondrial pyruvate transport	pyruvate transmembrane transporter activity	mitochondrion|mitochondrial membrane
YPL226W	YPL226W	NEW1	hom	Verified	0.624581651796798	0.266122832545677	no	1243	0.241781670460987	865	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|NUCLEOTIDE METABOLISM|RNA LOCALIZATION	NUCLEUS|MITOCHONDRION		ATP binding cassette protein that cosediments with polysomes and is required for biogenesis of the small ribosomal subunit; Asn/Gln-rich rich region supports [NU+] prion formation and susceptibility to [PSI+] prion induction	ribosomal small subunit biogenesis|poly(A)+ mRNA export from nucleus	ATPase activity|ATP binding	mitochondrion|polysome|cytoplasm
YCL040W	YCL040W	GLK1	hom	Verified	0.623915113971226	0.266341666955501	no	1244	0.271824383088477	925	NA	FT	CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY			Glucokinase; catalyzes the phosphorylation of glucose at C6 in the first irreversible step of glucose metabolism; one of three glucose phosphorylating enzymes; expression regulated by non-fermentable carbon sources; GLK1 has a paralog, EMI2, that arose from the whole genome duplication	glucose import|mannose metabolic process|glycolysis|glucose metabolic process	glucokinase activity	cytosol|plasma membrane
YPR149W	YPR149W	NCE102	hom	Verified	0.623180248252761	0.266583039938469	no	1245	0.252508115686781	885	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|PROTEIN PHOSPHORYLATION	ENDOPLASMIC RETICULUM|MITOCHONDRION|PLASMA MEMBRANE		Protein of unknown function; contains transmembrane domains; involved in secretion of proteins that lack classical secretory signal sequences; component of the detergent-insoluble glycolipid-enriched complexes (DIGs)	eisosome assembly|protein secretion|negative regulation of protein phosphorylation|plasma membrane organization|establishment of protein localization to plasma membrane	molecular_function	mitochondrion|integral to membrane|membrane raft|endoplasmic reticulum|cellular bud membrane|plasma membrane|mating projection membrane|cytoplasm
YLR130C	YLR130C	ZRT2	hom	Verified	0.622849887182634	0.266691585910101	no	1246	0.262033393823923	867	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Low-affinity zinc transporter of the plasma membrane; transcription is induced under low-zinc conditions by the Zap1p transcription factor	low-affinity zinc ion transport	low-affinity zinc ion transmembrane transporter activity	integral to membrane|plasma membrane
YPL090C	YPL090C	RPS6A	hom	Verified	0.622635838658359	0.266761927263469	no	1247	0.270488695817209	933	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S6, no bacterial homolog; RPS6A has a paralog, RPS6B, that arose from the whole genome duplication	cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome	small-subunit processome|cytosolic small ribosomal subunit|90S preribosome
YLR283W_p	YLR283W	YLR283W	hom	Uncharacterized	0.622090566108002	0.266941158938592	no	1248	0.249381805697083	853	NA	FT		MITOCHONDRION		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR283W is not an essential gene	biological_process	molecular_function	mitochondrion
YJL068C	YJL068C	YJL068C	hom	Verified	0.621990373923079	0.266974098831849	no	1249	0.250535606822593	847	NA					Non-essential intracellular esterase that can function as an S-formylglutathione hydrolase; may be involved in the detoxification of formaldehyde, which can be metabolized to S-formylglutathione; similar to human esterase D	formaldehyde catabolic process	S-formylglutathione hydrolase activity	cytosol
YHR142W	YHR142W	CHS7	hom	Verified	0.621424928030118	0.267160037312155	no	1250	0.426303900367058	1385	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein of unknown function; may be involved in chitin biosynthesis by regulation of Chs3p export from the ER; relocalizes from bud neck to ER upon DNA replication stress	protein folding|ER to Golgi vesicle-mediated transport|fungal-type cell wall chitin biosynthetic process	unfolded protein binding	integral to membrane|endoplasmic reticulum membrane
YER091C	YER091C	MET6	hom	Verified	0.620445316483072	0.267482322664887	no	1251	0.189035528364891	643	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Cobalamin-independent methionine synthase, involved in methionine biosynthesis and regeneration; requires a minimum of two glutamates on the methyltetrahydrofolate substrate, similar to bacterial metE homologs	methionine biosynthetic process	5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity	plasma membrane|cytoplasm
YER075C	YER075C	PTP3	hom	Verified	0.620085009641651	0.267600910395918	no	1252	0.24859993919103	865	NA	FT	PROTEIN LOCALIZATION|SIGNALING|PROTEIN PHOSPHORYLATION	NUCLEUS		Phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing; dephosporylates Hog1p MAPK and regulates its localization; localized to the cytoplasm	inactivation of MAPK activity involved in osmosensory signaling pathway|regulation of sporulation|regulation of protein localization|protein dephosphorylation|inactivation of MAPK activity involved in conjugation with cellular fusion	protein tyrosine phosphatase activity	nucleus|cytoplasm
YIL007C	YIL007C	NAS2	hom	Verified	0.619279790219857	0.267866027896384	no	1253	0.239225235585804	821	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS	NUCLEUS		Proteasome-interacting protein; involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); similar to mammalian proteasomal modulator subunit; non-essential gene; interacts with Rpn4p; protein abundance increases in response to DNA replication stress	proteasome regulatory particle assembly|ubiquitin-dependent protein catabolic process	molecular_function	cytosol|nucleus|cytoplasm
YLR328W	YLR328W	NMA1	hom	Verified	0.618553841363432	0.268105159013208	no	1254	0.298907559963279	997	NA	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM	NUCLEUS		Nicotinic acid mononucleotide adenylyltransferase; catalyzes the transfer of the adenylyl moiety of ATP to nicotinamide mononucleotide to form NAD; involved in pathways of NAD biosynthesis, including the de novo, NAD(+) salvage, and nicotinamide riboside salvage pathways; NMA1 has a paralog, NMA2, that arose from the whole genome duplication	NAD biosynthetic process	nicotinamide-nucleotide adenylyltransferase activity	nucleus|cytoplasm
YBR073W	YBR073W	RDH54	hom	Verified	0.617104872643466	0.268582777471947	no	1255	0.296718468151371	1032	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION	NUCLEUS		DNA-dependent ATPase; stimulates strand exchange by modifying the topology of double-stranded DNA; involved in recombinational repair of DNA double-strand breaks during mitosis and meiosis; proposed to be involved in crossover interference; interacts with Dmc1p; stimulates Dmc1p and Rad51p	DNA geometric change|heteroduplex formation|meiotic sister chromatid segregation|reciprocal meiotic recombination|double-strand break repair via break-induced replication	DNA-dependent ATPase activity|DNA translocase activity	nucleus
YDL094C_d	YDL094C	YDL094C	hom	Dubious	0.616915170477953	0.268645339973059	no	1256	0.245089774155096	867	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verfied gene PMT5/YDL093W; YDL094C is not essential	Unknown	Unknown	Unknown
YDR504C	YDR504C	SPG3	hom	Verified	0.616217691091295	0.268875426934924	no	1257	0.247337489515245	856	NA					Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources	biological_process	molecular_function	cellular_component
YMR172C-A_d	YMR172C-A	YMR172C-A	hom	Dubious	0.615851980257394	0.268996108448198	no	1258	0.265615461546151	921	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YFL047W	YFL047W	RGD2	hom	Verified	0.612995566366467	0.26993963565584	no	1259	0.2750030939004	946	NA	FT	SIGNALING	SITE OF POLARIZED GROWTH		GTPase-activating protein (RhoGAP) for Cdc42p and Rho5p; relocalizes from bud neck to cytoplasm upon DNA replication stress	small GTPase mediated signal transduction	Rho GTPase activator activity	cellular bud neck|cytoplasm
YLR371W	YLR371W	ROM2	hom	Verified	0.612398794697957	0.270136969535633	no	1260	0.362667073377205	1205	NA	FF|FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING|CELL WALL ORG/BIOGENESIS|NUCLEOTIDE METABOLISM	SITE OF POLARIZED GROWTH		GDP/GTP exchange factor (GEF) for Rho1p and Rho2p; mutations are synthetically lethal with mutations in rom1, which also encodes a GEF; Rom2p localization to the bud surface is dependent on Ack1p	regulation of fungal-type cell wall organization|positive regulation of endocytosis|establishment of cell polarity|small GTPase mediated signal transduction|negative regulation of cAMP-mediated signaling|activation of Rho GTPase activity	phosphatidylinositol-4,5-bisphosphate binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity	incipient cellular bud site|mating projection tip|cellular bud tip
YMR077C	YMR077C	VPS20	hom	Verified	0.610996874452452	0.270600824754338	no	1261	0.304631019284292	1038	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|PROTEOLYSIS|VACUOLAR TRANSPORT			Myristoylated subunit of ESCRTIII, the endosomal sorting complex required for transport of transmembrane proteins into the multivesicular body pathway to the lysosomal/vacuolar lumen; cytoplasmic protein recruited to endosomal membranes	intralumenal vesicle formation|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|late endosome to vacuole transport	protein binding	ESCRT III complex|cytoplasm
YPL008W	YPL008W	CHL1	hom	Verified	0.61089285544216	0.27063525751053	no	1262	0.277835131076422	975	NA	FT	CELL CYCLE|CHROMOSOME SEGREGATION	NUCLEUS		Probable DNA helicase; involved in sister-chromatid cohesion and genome integrity and interstrand cross-link repair; interacts with ECO1 and CTF18; mutants are defective in silencing, rDNA recombination, aging and the heat shock response; FANCJ-like helicase family member; mutations in the human homolog, DDX11/ChLR1, cause Warsaw breakage syndrome	negative regulation of DNA recombination|chromosome segregation|donor selection|DNA replication initiation|mitotic sister chromatid cohesion	DNA helicase activity	nucleus
YIL092W_p	YIL092W	YIL092W	hom	Uncharacterized	0.609813073517772	0.270992820107618	no	1263	0.268636949683466	921	NA	FT		NUCLEUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus	biological_process	molecular_function	nucleus|cytoplasm
YJR077C	YJR077C	MIR1	hom	Verified	0.609395988964823	0.271130997952446	no	1264	0.263213142432461	905	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; functionally redundant with Pic2p but more abundant than Pic2p under normal conditions; phosphorylated	phosphate ion transmembrane transport	inorganic phosphate transmembrane transporter activity	mitochondrion|integral to membrane|integral to mitochondrial inner membrane
YLR296W_d	YLR296W	YLR296W	hom	Dubious	0.609341954503352	0.271148901846127	no	1265	0.271224351127357	925	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YBL089W	YBL089W	AVT5	hom	Verified	0.609094351783236	0.271230950598588	no	1266	0.300476716586542	1004	NA					Putative transporter; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters; AVT5 has a paralog, AVT6, that arose from the whole genome duplication	transport	transporter activity	integral to membrane
YLR312W-A	YLR312W-A	MRPL15	hom	Verified	0.608619183016525	0.271388443158508	no	1267	0.27850837192525	978	NA	FT	RNA PROCESSING|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YDR441C	YDR441C	APT2	hom	Verified	0.607003727895449	0.271924219081857	no	1268	0.265833047072834	891	NA					Potential adenine phosphoribosyltransferase; encodes a protein with similarity to adenine phosphoribosyltransferase, but artificially expressed protein exhibits no enzymatic activity; APT2 has a paralog, APT1, that arose from the whole genome duplication	biological_process	adenine phosphoribosyltransferase activity|molecular_function	cytoplasm
YJL180C	YJL180C	ATP12	hom	Verified	0.604890232524244	0.27262596676065	no	1269	0.272916424245264	958	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Conserved protein required for assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase; mutation of human ATP12 reduces active ATP synthase levels and is associated with the disorder ATPAF2 deficiency	mitochondrial proton-transporting ATP synthase complex assembly	protein domain specific binding	mitochondrion
YCR045C	YCR045C	RRT12	hom	Verified	0.603185972557695	0.273192489167915	no	1270	0.279869813030824	987	NA	FT	CELL WALL ORG/BIOGENESIS|PROTEOLYSIS	ENDOMEMBRANE SYSTEM|NUCLEUS		Probable subtilisin-family protease with a role in formation of the dityrosine layer of spore walls; localizes to the spore wall and also the nuclear envelope and ER region in mature spores	ascospore wall assembly	serine-type peptidase activity	nuclear envelope|ascospore wall
YPL269W	YPL269W	KAR9	hom	Verified	0.602186312217401	0.273525062940775	no	1271	0.323649156596519	1089	NA	FT		NUCLEUS|SITE OF POLARIZED GROWTH|CYTOSKELETON		Karyogamy protein required for correct positioning of the mitotic spindle and for orienting cytoplasmic microtubules, localizes at the shmoo tip in mating cells and at the tip of the growing bud in small-budded cells through anaphase	nuclear migration along microtubule|establishment of spindle localization	molecular_function	cell cortex|spindle pole body|mating projection tip
YIL102C_p	YIL102C	YIL102C	hom	Uncharacterized	0.601776686009221	0.273661398017661	no	1272	0.259855099073919	865	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YBR255W	YBR255W	MTC4	hom	Verified	0.599748228582877	0.274337020516814	no	1273	0.2959716056224	1005	NA					Protein of unknown function, required for normal growth rate at 15 degrees C; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; mtc4 is synthetically sick with cdc13-1	biological_process	molecular_function	cytoplasm
YAR035W	YAR035W	YAT1	hom	Verified	0.599725821436431	0.274344488307244	no	1274	0.259797886484856	900	NA	FT	KETONE METABOLISM|LIPID METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		Outer mitochondrial carnitine acetyltransferase, minor ethanol-inducible enzyme involved in transport of activated acyl groups from the cytoplasm into the mitochondrial matrix; phosphorylated	carnitine metabolic process|alcohol metabolic process	carnitine O-acetyltransferase activity	mitochondrion
YGR174C	YGR174C	CBP4	hom	Verified	0.599646595852787	0.274370893190495	no	1275	0.26929195849121	910	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial protein required for assembly of cytochrome bc1 complex; interacts with the Cbp3p-Cbp6p complex and newly synthesized cytochrome b (Cobp) to promote assembly of Cobp into the cytochrome bc1 complex	mitochondrial respiratory chain complex III assembly	molecular_function	mitochondrion|integral to mitochondrial membrane
YJR118C	YJR118C	ILM1	hom	Verified	0.598870900792554	0.274629488778818	no	1276	0.305112624352922	1024	NA	FF|FT	MITOCHONDRION ORGANIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein of unknown function; may be involved in mitochondrial DNA maintenance; required for slowed DNA synthesis-induced filamentous growth	mitochondrial genome maintenance	molecular_function	integral to membrane|endoplasmic reticulum
YGL156W	YGL156W	AMS1	hom	Verified	0.598397093878479	0.274787502206357	no	1277	0.274452287999478	942	NA	FT	CARBOHYDRATE METABOLISM			Vacuolar alpha mannosidase, involved in free oligosaccharide (fOS) degradation; delivered to the vacuole in a novel pathway separate from the secretory pathway	oligosaccharide catabolic process|cellular carbohydrate metabolic process	alpha-mannosidase activity	fungal-type vacuole membrane
YML067C	YML067C	ERV41	hom	Verified	0.597384900893822	0.275125216125816	no	1278	0.276863294763763	934	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Protein localized to COPII-coated vesicles, forms a complex with Erv46p; involved in the membrane fusion stage of transport; has homology to human ERGIC2 (PTX1) protein	ER to Golgi vesicle-mediated transport	molecular_function	integral to endoplasmic reticulum membrane|integral to Golgi membrane|ER to Golgi transport vesicle
YGR242W_d	YGR242W	YGR242W	hom	Dubious	0.597246721962299	0.275171334794449	no	1279	0.27707330407427	935	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YAP1802/YGR241C	Unknown	Unknown	Unknown
YKL127W	YKL127W	PGM1	hom	Verified	0.596577930053779	0.275394604895838	no	1280	0.245486397478656	819	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY			Phosphoglucomutase, minor isoform; catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism	glucose 6-phosphate metabolic process|galactose catabolic process|glucose 1-phosphate metabolic process|UDP-glucose metabolic process|trehalose biosynthetic process|glycogen biosynthetic process	phosphoglucomutase activity	cytoplasm
YDR206W	YDR206W	EBS1	hom	Verified	0.595630924871812	0.275710906361363	no	1281	0.282979975715486	932	NA	FT	TRANSLATION	NUCLEUS|CHROMOSOME		Protein involved in inhibition of translation and nonsense-mediated decay; interacts with cap binding protein Cdc33p and with Nam7p; localizes to P-bodies upon glucose starvation; mRNA abundance regulated by mRNA decay factors	negative regulation of translation|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	molecular_function	cytoplasmic mRNA processing body|cytoplasm
YFL034W_p	YFL034W	YFL034W	hom	Uncharacterized	0.59448860162707	0.276092681873904	no	1282	0.279678746064609	996	NA					Putative integral membrane protein that interacts with Rpp0p, which is a component of the ribosomal stalk	biological_process	molecular_function	integral to membrane
YNL227C	YNL227C	JJJ1	hom	Verified	0.593607530142956	0.276387321692354	no	1283	0.227032599938808	789	NA	FT	VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS|MITOCHONDRION	RIBOSOME	Co-chaperone that stimulates the ATPase activity of Ssa1p, required for a late step of ribosome biogenesis; associated with the cytosolic large ribosomal subunit; contains a J-domain; mutation causes defects in fluid-phase endocytosis	ribosomal subunit export from nucleus|ribosomal large subunit biogenesis|endocytosis|regulation of cell size|rRNA processing	ATPase activator activity	cytosol|mitochondrion|cytosolic large ribosomal subunit|nucleolus|cytoplasm
YNL305C	YNL305C	BXI1	hom	Verified	0.593038347476895	0.276577744483346	no	1284	0.255940316129895	852	NA	FT	SIGNALING	ENDOPLASMIC RETICULUM|MITOCHONDRION		Protein involved in apoptosis; variously described as containing a BCL-2 homology (BH3) domain or as a member of the BAX inhibitor family; reported to promote apoptosis under some conditions and to inhibit it in others; localizes to ER and vacuole; may link the unfolded protein response to apoptosis via regulation of calcium-mediated signaling; translocates to mitochondria under apoptosis-inducing conditions in a process involving Mir1p and Cor1p	endoplasmic reticulum unfolded protein response|apoptotic process|calcium-mediated signaling	molecular_function	mitochondrion|integral to membrane|endoplasmic reticulum|fungal-type vacuole
YOR118W	YOR118W	RTC5	hom	Verified	0.592554129795679	0.276739792441656	no	1285	0.299201846274702	1039	NA					Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; null mutation suppresses cdc13-1 temperature sensitivity	biological_process	molecular_function	cytoplasm
YIL070C	YIL070C	MAM33	hom	Verified	0.591016685063706	0.277254620753966	no	1286	0.284457083490057	992	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Acidic protein of the mitochondrial matrix involved in oxidative phosphorylation; related to the human complement receptor gC1q-R	aerobic respiration	molecular_function	mitochondrion|mitochondrial matrix
YJL117W	YJL117W	PHO86	hom	Verified	0.589347158483782	0.277814207982959	no	1287	0.263072270303649	913	NA	FT	VESICLE-MEDIATED TRANSPORT|ION HOMEOSTASIS|ION HOMEOSTASIS	ENDOPLASMIC RETICULUM		Endoplasmic reticulum (ER) resident protein; required for ER exit of the high-affinity phosphate transporter Pho84p, specifically required for packaging of Pho84p into COPII vesicles; protein abundance increases in response to DNA replication stress	protein folding|ER to Golgi vesicle-mediated transport|regulation of phosphate transport	unfolded protein binding	endoplasmic reticulum
YDR262W_p	YDR262W	YDR262W	hom	Uncharacterized	0.589213135879171	0.277859153202165	no	1288	0.251031524621724	857	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole and is induced in response to the DNA-damaging agent MMS; gene expression increases in response to Zymoliase treatment	biological_process	molecular_function	fungal-type vacuole
YKR028W	YKR028W	SAP190	hom	Verified	0.5885568796146	0.278079283589121	no	1289	0.27760610244185	944	NA	FT	CELL CYCLE|RNA PROCESSING|SIGNALING			Protein that forms a complex with the Sit4p protein phosphatase; required for Sit4p function; member of a family of similar proteins including Sap4p, Sap155p, and Sap185p; SAP190 has a paralog, SAP185, that arose from the whole genome duplication	TOR signaling cascade|dephosphorylation|G1/S transition of mitotic cell cycle|tRNA wobble uridine modification	molecular_function	cytoplasm
YML042W	YML042W	CAT2	hom	Verified	0.588555035335996	0.278079902341951	no	1290	0.268316712547736	886	NA	FT	KETONE METABOLISM|LIPID METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		Carnitine acetyl-CoA transferase present in both mitochondria and peroxisomes, transfers activated acetyl groups to carnitine to form acetylcarnitine which can be shuttled across membranes	carnitine metabolic process	carnitine O-acetyltransferase activity	mitochondrion|peroxisomal matrix|peroxisome
YLL002W	YLL002W	RTT109	hom	Verified	0.588223526500817	0.278191133990686	no	1291	0.283250757394354	976	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE	NUCLEUS		Histone acetyltransferase critical for cell survival in the presence of DNA damage during S phase; acetylates H3-K56 and H3-K9; involved in non-homologous end joining and in regulation of Ty1 transposition; interacts physically with Vps75p	negative regulation of transposition, RNA-mediated|histone acetylation|double-strand break repair via nonhomologous end joining|response to DNA damage stimulus|regulation of transcription from RNA polymerase II promoter in response to stress	H3 histone acetyltransferase activity	nucleus
YHR109W	YHR109W	CTM1	hom	Verified	0.586887312864871	0.278639695573714	no	1292	0.25533780469492	861	NA					Cytochrome c lysine methyltransferase, trimethylates residue 72 of apo-cytochrome c (Cyc1p) in the cytosol; not required for normal respiratory growth	peptidyl-lysine methylation	[cytochrome c]-lysine N-methyltransferase activity	cytosol
YDL086W_p	YDL086W	YDL086W	hom	Uncharacterized	0.586612760292954	0.27873190537444	no	1293	0.237927935346168	815	NA	FT		MITOCHONDRION		Putative carboxymethylenebutenolidase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL086W is not an essential gene	biological_process	carboxymethylenebutenolidase activity	mitochondrion|cytoplasm
YOR150W	YOR150W	MRPL23	hom	Verified	0.586430708202474	0.278793056633467	no	1294	0.315264142646065	1043	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YPL253C	YPL253C	VIK1	hom	Verified	0.586287118387633	0.278841293027807	no	1295	0.281988382708261	979	NA	FT	CELL CYCLE|CHROMOSOME SEGREGATION	NUCLEUS|CYTOSKELETON		Protein that forms a complex with Kar3p at the spindle pole body, possible regulator of Kar3p function in microtubule-mediated processes; required for sister chromatid cohesion; has similarity to Cik1p	microtubule-based process|mitotic sister chromatid cohesion	microtubule motor activity	kinesin complex|spindle pole body
YPR128C	YPR128C	ANT1	hom	Verified	0.586098722677091	0.278904587309587	no	1296	0.281338992117665	967	NA	FT	KETONE METABOLISM|LIPID METABOLISM|ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|PEROXISOME ORGANIZATION			Peroxisomal adenine nucleotide transporter; involved in beta-oxidation of medium-chain fatty acid; required for peroxisome proliferation	ATP transport|fatty acid beta-oxidation|peroxisome organization	adenine nucleotide transmembrane transporter activity	integral to membrane|cytoplasm|integral to peroxisomal membrane
YDL023C_d	YDL023C	YDL023C	hom	Dubious	0.585503049660236	0.279104758310347	no	1297	0.29060199604705	993	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in other Saccharomyces species; overlaps the verified gene GPD1; deletion confers sensitivity to GSAO; deletion in cyr1 mutant results in loss of stress resistance	Unknown	Unknown	Unknown
YOL003C	YOL003C	PFA4	hom	Verified	0.585168894948567	0.279217078817759	no	1298	0.280575083434463	951	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases	protein palmitoylation	palmitoyltransferase activity	integral to membrane|endoplasmic reticulum
YLR405W	YLR405W	DUS4	hom	Verified	0.585089838044487	0.279243655684787	no	1299	0.268430239247947	906	NA	FT	RNA PROCESSING|OXIDATION-REDUCTION PROCESS			Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus3p	tRNA modification	tRNA dihydrouridine synthase activity	cellular_component
YCR081W	YCR081W	SRB8	hom	Verified	0.584762674910029	0.279353652457868	no	1300	0.295512464258255	1013	NA	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; involved in glucose repression	negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription by galactose|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II transcription coactivator activity	mediator complex
YGR271C-A	YGR271C-A	EFG1	hom	Verified	0.584619805119455	0.279401693860944	no	1301	0.322546495799133	1098	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Essential protein required for maturation of 18S rRNA; null mutant is sensitive to hydroxyurea and is delayed in recovering from alpha-factor arrest; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus	G1 phase of mitotic cell cycle|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	molecular_function	nucleolus
YHL047C	YHL047C	ARN2	hom	Verified	0.584428355525861	0.279466077002431	no	1302	0.27570770776519	945	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|COFACTOR METABOLISM	PLASMA MEMBRANE		Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to the siderophore triacetylfusarinine C	cellular iron ion homeostasis|siderophore transport|siderophore metabolic process	siderophore transmembrane transporter activity	endosome|integral to membrane|cytoplasmic membrane-bounded vesicle|plasma membrane
YHR160C	YHR160C	PEX18	hom	Verified	0.583997129947689	0.279611121493994	no	1303	0.290334334693299	979	NA	FT	PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION			Peroxin required for targeting of peroxisomal matrix proteins containing PTS2; interacts with Pex7p; partially redundant with Pex21p	protein import into peroxisome matrix	protein binding	cytosol|peroxisome
YIL020C	YIL020C	HIS6	hom	Verified	0.580620188215937	0.280748231489944	no	1304	0.276549169431483	951	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Phosphoribosyl-5-amino-1-phosphoribosyl-4-imidazolecarboxiamide isomerase, catalyzes the fourth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts	histidine biosynthetic process	1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity	intracellular
YLR039C	YLR039C	RIC1	hom	Verified	0.580229869313252	0.28087980674369	no	1305	0.374692144991476	1249	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|NUCLEUS|GOLGI APPARATUS		Protein involved in retrograde transport to the cis-Golgi network; forms heterodimer with Rgp1p that acts as a GTP exchange factor for Ypt6p; involved in transcription of rRNA and ribosomal protein genes	intracellular protein transport|retrograde transport, endosome to Golgi	guanyl-nucleotide exchange factor activity	nucleus|Ric1p-Rgp1p complex|Golgi membrane|guanyl-nucleotide exchange factor complex
YER064C	YER064C	VHR2	hom	Verified	0.579850951255499	0.281007567318021	no	1306	0.260936113616354	887	NA	FT		NUCLEUS		Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress	regulation of transcription, DNA-dependent	molecular_function	nucleus
YCR085W_d	YCR085W	YCR085W	hom	Dubious	0.578464466334849	0.281475290475433	no	1307	0.27312793854587	958	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YHL028W	YHL028W	WSC4	hom	Verified	0.578444423401637	0.281482054603251	no	1308	0.266762385679014	899	NA	FT	PROTEIN LOCALIZATION|CELL WALL ORG/BIOGENESIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		ER membrane protein involved in the translocation of soluble secretory proteins and insertion of membrane proteins into the ER membrane; may also have a role in the stress response but has only partial functional overlap with WSC1-3	response to heat|SRP-dependent cotranslational protein targeting to membrane, translocation|protein targeting to ER|response to stress	transmembrane signaling receptor activity	endoplasmic reticulum membrane
YJL157C	YJL157C	FAR1	hom	Verified	0.577262751861289	0.281880985941853	no	1309	0.236255923815123	808	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|SIGNALING|CELL DIVISION	NUCLEUS|SITE OF POLARIZED GROWTH		Cyclin-dependent kinase inhibitor; mediates cell cycle arrest in response to pheromone; also forms a complex with Cdc24p, Ste4p, and Ste18p that may specify the direction of polarized growth during mating; potential Cdc28p substrate; relocalizes from nucleus to cytoplasm upon DNA replication stress	maintenance of protein location in nucleus|pheromone-dependent signal transduction involved in conjugation with cellular fusion|cell cycle arrest in response to pheromone	cyclin-dependent protein kinase inhibitor activity	nucleus|mating projection tip|membrane|cytoplasm
YLR218C	YLR218C	COA4	hom	Verified	0.57535217491972	0.28252657086156	no	1310	0.264553608522352	898	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION	NUCLEUS|MITOCHONDRION		Twin Cx(9)C protein involved in cytochrome c oxidase assembly or stability; localizes to the mitochondrial intermembrane space via the Mia40p-Erv1p system; interacts genetically with CYC1 and with cytochrome c oxidase assembly factors	mitochondrial respiratory chain complex IV assembly|mitochondrial respiratory chain complex assembly	molecular_function	nucleus|mitochondrial intermembrane space|cytoplasm
YBR294W	YBR294W	SUL1	hom	Verified	0.574958756053153	0.282659595507685	no	1311	0.257391551642031	848	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		High affinity sulfate permease of the SulP anion transporter family; sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p, which control the concentration of endogenous activated sulfate intermediates	sulfate transport|transmembrane transport	sulfate transmembrane transporter activity	integral to membrane|plasma membrane
YDL219W	YDL219W	DTD1	hom	Verified	0.574156071665011	0.282931096266337	no	1312	0.26063358121264	899	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION			D-Tyr-tRNA(Tyr) deacylase, functions in protein translation, may affect nonsense suppression via alteration of the protein synthesis machinery; ubiquitous among eukaryotes	Unknown	D-leucyl-tRNA(Leu) deacylase activity|D-tyrosyl-tRNA(Tyr) deacylase activity	cytoplasm
YEL028W_d	YEL028W	YEL028W	hom	Dubious	0.573888177209452	0.283021737012198	no	1313	0.301406031045171	1047	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDR294C	YDR294C	DPL1	hom	Verified	0.573381139149956	0.283193328943899	no	1314	0.256014536109171	852	NA	FT	KETONE METABOLISM|LIPID METABOLISM|SIGNALING|RESPONSE TO NUTRIENT LEVELS	ENDOPLASMIC RETICULUM		Dihydrosphingosine phosphate lyase, regulates intracellular levels of sphingolipid long-chain base phosphates (LCBPs), degrades phosphorylated long chain bases, prefers C16 dihydrosphingosine-l-phosphate as a substrate	calcium-mediated signaling|sphingolipid metabolic process|cellular response to starvation	sphinganine-1-phosphate aldolase activity	endoplasmic reticulum|cortical endoplasmic reticulum|perinuclear endoplasmic reticulum
YOL020W	YOL020W	TAT2	hom	Verified	0.570602568639464	0.284134538471357	no	1315	0.302385395510563	1016	NA	FT		PLASMA MEMBRANE		High affinity tryptophan and tyrosine permease, overexpression confers FK506 and FTY720 resistance	aromatic amino acid transport|tryptophan transport	high-affinity tryptophan transmembrane transporter activity|aromatic amino acid transmembrane transporter activity	integral to membrane|plasma membrane
YNL339C	YNL339C	YRF1-6	hom	Verified	0.57006194786789	0.28431784138908	no	1316	0.265032321522494	892	NA	FT		NUCLEUS		Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p	telomere maintenance via recombination	DNA helicase activity	nucleus
YKL061W_p	YKL061W	BLI1	hom	Uncharacterized	0.569633858643523	0.284463029437409	no	1317	0.275108364997403	917	NA					Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to the endosome	biological_process	molecular_function	endosome
YNL117W	YNL117W	MLS1	hom	Verified	0.569499892060094	0.284508471976239	no	1318	0.294819791707628	993	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM			Malate synthase, enzyme of the glyoxylate cycle; involved in utilization of non-fermentable carbon sources; expression is subject to carbon catabolite repression; localizes in peroxisomes during growth on oleic acid, otherwise cytosolic	glyoxylate cycle	malate synthase activity	peroxisomal matrix|cytoplasm
YMR230W-A_p	YMR230W-A	YMR230W-A	hom	Uncharacterized	0.569385174754426	0.284547387761436	no	1319	0.282519753450304	982	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YLL042C	YLL042C	ATG10	hom	Verified	0.568002273895035	0.285016711958205	no	1320	0.263530321724159	907	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS			Conserved E2-like conjugating enzyme that mediates formation of the Atg12p-Atg5p conjugate, which is a critical step in autophagy	piecemeal microautophagy of nucleus|cellular protein modification process|mitochondrion degradation|macroautophagy|CVT pathway	Atg12 ligase activity	cellular_component
YBR094W	YBR094W	PBY1	hom	Verified	0.567772081931785	0.285094869544489	no	1321	0.269250870953457	907	NA					Putative tubulin tyrosine ligase associated with P-bodies; forms cytoplasmic foci upon DNA replication stress	nuclear-transcribed mRNA catabolic process|biological_process	molecular_function	cytoplasmic mRNA processing body|cytoplasm
YEL051W	YEL051W	VMA8	hom	Verified	0.566308026099611	0.285592202645668	no	1322	0.311435670881559	1052	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Subunit D of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; plays a role in the coupling of proton transport and ATP hydrolysis	vacuolar acidification	proton-transporting ATPase activity, rotational mechanism	fungal-type vacuole membrane|vacuolar proton-transporting V-type ATPase, V1 domain|integral to membrane
YLL051C	YLL051C	FRE6	hom	Verified	0.564586119569942	0.286177654289489	no	1323	0.256577585346668	880	NA	FT	ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|GEN. OF PRECURSOR METABOLITES AND ENERGY			Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels	intracellular sequestering of iron ion|copper ion import	ferric-chelate reductase activity	fungal-type vacuole membrane|integral to membrane|fungal-type vacuole
YGR106C	YGR106C	VOA1	hom	Verified	0.560816203517893	0.287461419713978	no	1324	0.346161144475522	1151	NA	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Endoplasmic reticulum protein that functions, together with other assembly factors, in assembly of the V0 sector of the vacuolar ATPase (V-ATPase); null mutation enhances the V-ATPase deficiency of a vma21 mutant impaired in ER retrieval	protein complex assembly	molecular_function	fungal-type vacuole membrane|endoplasmic reticulum membrane
YGR096W	YGR096W	TPC1	hom	Verified	0.560566285957538	0.287546620037748	no	1325	0.320636050491372	1076	NA	FT		MITOCHONDRION		Mitochondrial membrane transporter that mediates uptake of the essential cofactor thiamine pyrophosphate (ThPP) into mitochondria; expression appears to be regulated by carbon source; member of the mitochondrial carrier family	thiamine pyrophosphate transport	thiamine transmembrane transporter activity	integral to membrane|integral to mitochondrial inner membrane
YPL215W	YPL215W	CBP3	hom	Verified	0.559951651450952	0.287756208141284	no	1326	0.26095609262026	915	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex	positive regulation of mitochondrial translation|mitochondrial respiratory chain complex III assembly	ribosome binding	integral to mitochondrial membrane|mitochondrion|mitochondrial ribosome
YMR194W	YMR194W	RPL36A	hom	Verified	0.559176893575884	0.288020500503585	no	1327	0.272915022901732	918	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L36A; N-terminally acetylated; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L36, no bacterial homolog; RPL36A has a paralog, RPL36B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome|RNA binding	cytosolic large ribosomal subunit
YNL146W_p	YNL146W	YNL146W	hom	Uncharacterized	0.55897645204756	0.2880888955689	no	1328	0.294315121231917	1015	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YNL146W is not an essential gene	biological_process	molecular_function	endoplasmic reticulum
YFR032C-A	YFR032C-A	RPL29	hom	Verified	0.558868696680172	0.288125667241612	no	1329	0.28958142803034	982	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L29; not essential for translation, but required for proper joining of large and small ribosomal subunits and for normal translation rate; homologous to mammalian ribosomal protein L29, no bacterial homolog	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit|cytoplasm
YGR097W	YGR097W	ASK10	hom	Verified	0.558668120284164	0.288194120119885	no	1330	0.293755195867928	1022	NA	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO OXIDATIVE STRESS	NUCLEUS	RNA POL II, HOLOENZYME	Component of RNA polymerase II holoenzyme; phosphorylated in response to oxidative stress; has a role in destruction of Ssn8p; proposed to function in activation of the glycerol channel Fps1p; ASK10 has a paralog, RGC1, that arose from the whole genome duplication	cellular protein catabolic process|cellular response to oxidative stress|positive regulation of transcription from RNA polymerase II promoter|positive regulation of glycerol transport	molecular_function	DNA-directed RNA polymerase II, holoenzyme|cytoplasm
YOL006C	YOL006C	TOP1	hom	Verified	0.558247847715914	0.288337575963033	no	1331	0.284032092632151	951	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|CHROMOSOME SEGREGATION|GENE SILENCING	NUCLEUS|CHROMOSOME		Topoisomerase I, nuclear enzyme that relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone; relaxes both positively and negatively supercoiled DNA; functions in replication, transcription, and recombination	nuclear migration|chromatin assembly or disassembly|DNA topological change|DNA strand elongation involved in DNA replication|regulation of mitotic recombination|chromatin silencing at rDNA|regulation of transcription from RNA polymerase II promoter|mitotic chromosome condensation|transcription elongation from RNA polymerase II promoter	DNA topoisomerase type I activity	replication fork protection complex|nucleolus|nucleus
YLR300W	YLR300W	EXG1	hom	Verified	0.557713728066462	0.288519940941519	no	1332	0.271161492596143	914	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM			Major exo-1,3-beta-glucanase of the cell wall, involved in cell wall beta-glucan assembly; exists as three differentially glycosylated isoenzymes	fungal-type cell wall organization|cellular glucan metabolic process	glucan exo-1,3-beta-glucosidase activity	extracellular region|fungal-type cell wall
YOR316C	YOR316C	COT1	hom	Verified	0.557381881953102	0.288633270841441	no	1333	0.302806322650079	1011	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Vacuolar transporter that mediates zinc transport into the vacuole; overexpression confers resistance to cobalt and rhodium; protein abundance increases in response to DNA replication stress; COT1 has a paralog, ZRC1, that arose from the whole genome duplication	cellular zinc ion homeostasis|cobalt ion transport|zinc ion transport	cobalt ion transmembrane transporter activity|zinc ion transmembrane transporter activity|inorganic cation transmembrane transporter activity	mitochondrion|integral to membrane|fungal-type vacuole
YPL250C	YPL250C	ICY2	hom	Verified	0.555299162050181	0.289345025960178	no	1334	0.317850613620736	1108	NA					Protein of unknown function; mobilized into polysomes upon a shift from a fermentable to nonfermentable carbon source; potential Cdc28p substrate	mitochondrion degradation	molecular_function	cellular_component
YJL122W	YJL122W	ALB1	hom	Verified	0.555232172713098	0.289367932786177	no	1335	0.261634294281077	924	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS	NUCLEUS		Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit; interacts directly with Arx1p; responsible for Tif6p recycling defects in absence of Rei1p	ribosomal large subunit biogenesis	molecular_function	ribosome|nucleus|cytoplasm
YHL013C	YHL013C	OTU2	hom	Verified	0.555149983158702	0.289396038450085	no	1336	0.266166422082697	928	NA					Protein of unknown function; may interact with ribosomes, based on co-purification experiments; member of the ovarian tumor-like (OTU) superfamily of predicted cysteine proteases; shows cytoplasmic localization; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	ribosome|cytoplasm
YHR091C	YHR091C	MSR1	hom	Verified	0.554042494356191	0.289774882002218	no	1337	0.276939981784422	987	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial arginyl-tRNA synthetase; mutations in human ortholog are associated with pontocerebellar hypoplasia type 6	arginyl-tRNA aminoacylation|mitochondrial arginyl-tRNA aminoacylation|mitochondrial translation	arginine-tRNA ligase activity	mitochondrion
YPL267W	YPL267W	ACM1	hom	Verified	0.552340244001921	0.290357631508108	no	1338	0.294567145193477	1003	NA	FT	CELL CYCLE|CELL DIVISION	NUCLEUS		Pseudosubstrate inhibitor of the anaphase-promoting complex/cyclosome (APC/C), that suppresses APC/C [Cdh1]-mediated proteolysis of mitotic cyclins; associates with Cdh1p, Bmh1p and Bmh2p; cell cycle regulated protein	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	ubiquitin-protein ligase inhibitor activity	nucleus|cytoplasm
YKR095W	YKR095W	MLP1	hom	Verified	0.552061054592824	0.290453261751465	no	1339	0.286335184679821	941	NA	FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS|CYTOSKELETON		Myosin-like protein associated with the nuclear envelope, connects the nuclear pore complex with the nuclear interior; involved with Tel1p in telomere length control; involved with Pml1p and Pml39p in nuclear retention of unspliced mRNAs	protein localization to nuclear pore|poly(A)+ mRNA export from nucleus|protein import into nucleus|transcriptional activation by promoter-terminator looping|nuclear retention of unspliced pre-mRNA at the site of transcription|telomere tethering at nuclear periphery	ribonucleoprotein complex binding	nucleoplasm|nuclear envelope|integral to membrane|ribonucleoprotein complex|spindle pole body
YHR156C	YHR156C	LIN1	hom	Verified	0.551768579436072	0.290553458547313	no	1340	0.293654573315191	1011	NA	FT		NUCLEUS|CHROMOSOME		Non-essential component of U5 snRNP; nuclear protein; physically interacts with Irr1p of cohesin complex; may link together proteins involved in chromosome segregation, mRNA splicing and DNA replication	biological_process	protein binding	chromatin|nucleus|U4/U6 x U5 tri-snRNP complex|U5 snRNP
YDR244W	YDR244W	PEX5	hom	Verified	0.550582583186025	0.290959925481505	no	1341	0.309415676633301	1036	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|PEROXISOME ORGANIZATION			Peroxisomal membrane signal receptor for the C-terminal tripeptide signal sequence (PTS1) of peroxisomal matrix proteins, required for peroxisomal matrix protein import; also proposed to have PTS1-receptor independent functions	protein import into peroxisome matrix, docking	peroxisome matrix targeting signal-1 binding|protein binding, bridging	cytosol|peroxisomal membrane|peroxisome
YHR044C	YHR044C	DOG1	hom	Verified	0.550383120422858	0.291028311838712	no	1342	0.274761686165089	941	NA	FT	CARBOHYDRATE METABOLISM			2-deoxyglucose-6-phosphate phosphatase; paralogous to DOG2; member of a family of low molecular weight phosphatases; confers 2-deoxyglucose resistance when overexpressed, in vivo substrate has not yet been identified	glucose metabolic process	2-deoxyglucose-6-phosphatase activity	cellular_component
YLR344W	YLR344W	RPL26A	hom	Verified	0.549969321877141	0.291170207750822	no	1343	0.277764819194593	905	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L26A; binds to 5.8S rRNA; homologous to mammalian ribosomal protein L26 and bacterial L24; RPL26A has a paralog, RPL26B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome|RNA binding	cytosolic large ribosomal subunit
YOL002C	YOL002C	IZH2	hom	Verified	0.549757000038152	0.291243027700344	no	1344	0.289687268700956	997	NA	FT	KETONE METABOLISM|LIPID METABOLISM|ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Plasma membrane protein involved in zinc homeostasis and osmotin-induced apoptosis; transcription regulated by Zap1p, zinc and fatty acid levels; similar to mammalian adiponectins; deletion increases sensitivity to elevated zinc	response to zinc ion|cellular zinc ion homeostasis|response to toxin|cellular lipid metabolic process	protein binding|metal ion binding	integral to membrane|plasma membrane|membrane
YMR066W	YMR066W	SOV1	hom	Verified	0.54974060131533	0.291248652318429	no	1345	0.306793407798867	1046	NA	FT		MITOCHONDRION		Mitochondrial protein of unknown function	biological_process	molecular_function	mitochondrion
YKL155C	YKL155C	RSM22	hom	Verified	0.549289237826628	0.291403485937338	no	1346	0.292776546406285	998	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the small subunit; also predicted to be an S-adenosylmethionine-dependent methyltransferase	mitochondrial translation	structural constituent of ribosome|S-adenosylmethionine-dependent methyltransferase activity	mitochondrion|mitochondrial small ribosomal subunit
YDR079C-A	YDR079C-A	TFB5	hom	Verified	0.547958815557731	0.291860091044918	no	1347	0.290621429781227	1018	NA	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION	NUCLEUS	RNA POL II, HOLOENZYME	Component of the RNA polymerase II general transcription and DNA repair factor TFIIH; involved in transcription initiation and in nucleotide-excision repair; homolog of Chlamydomonas reinhardtii REX1-S protein involved in DNA repair	phosphorylation of RNA polymerase II C-terminal domain|nucleotide-excision repair|transcription from RNA polymerase II promoter	core RNA polymerase binding transcription factor activity	core TFIIH complex|holo TFIIH complex|nucleus
YOL037C_d	YOL037C	YOL037C	hom	Dubious	0.547950380985116	0.291862986879613	no	1348	0.305818949072949	1019	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOL036W	Unknown	Unknown	Unknown
YPL189C-A	YPL189C-A	COA2	hom	Verified	0.547248555695606	0.292103990838741	no	1349	0.289172938332253	965	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Cytochrome oxidase assembly factor; null mutation results in respiratory deficiency with specific loss of cytochrome oxidase activity; functions downstream of assembly factors Mss51p and Coa1p and interacts with assembly factor Shy1p	mitochondrial respiratory chain complex IV assembly	molecular_function	mitochondrial matrix
YPL213W	YPL213W	LEA1	hom	Verified	0.546091608633703	0.292501483833165	no	1350	0.293680052671935	1039	NA	FT	RNA PROCESSING	NUCLEUS		Component of U2 snRNP; disruption causes reduced U2 snRNP levels; physically interacts with Msl1p; putative homolog of human U2A' snRNP protein	mRNA splicing, via spliceosome	molecular_function	U2 snRNP|U2-type prespliceosome|cytoplasm
YIL100W_d	YIL100W	YIL100W	hom	Dubious	0.545974208998877	0.292541832941432	no	1351	0.300098959630033	1016	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the dubious ORF YIL100C-A	Unknown	Unknown	Unknown
YBR101C	YBR101C	FES1	hom	Verified	0.54410143762777	0.293185835615922	no	1352	0.291953478898339	1022	NA	FT	TRANSLATION		RIBOSOME	Hsp70 (Ssa1p) nucleotide exchange factor; cytosolic homolog of Sil1p, which is the nucleotide exchange factor for BiP (Kar2p) in the endoplasmic reticulum; protein abundance increases in response to DNA replication stress	cytoplasmic translation	adenyl-nucleotide exchange factor activity	cytosol|cytosolic ribosome
YDR535C_d	YDR535C	YDR535C	hom	Dubious	0.543903700436534	0.293253871202488	no	1353	0.326970692626252	1120	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YDR535C is not an essential gene.	Unknown	Unknown	Unknown
YEL072W	YEL072W	RMD6	hom	Verified	0.543814177985076	0.293284675667327	no	1354	0.288632825415095	1001	NA	FT	CELL CYCLE			Protein required for sporulation	biological_process	molecular_function	cellular_component
YNR037C	YNR037C	RSM19	hom	Verified	0.543226307973434	0.293486997605935	no	1355	0.3120975742175	1074	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S19 ribosomal protein	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YHR140W_p	YHR140W	YHR140W	hom	Uncharacterized	0.542935264061663	0.293587187492351	no	1356	0.273949440650776	944	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Putative integral membrane protein of unknown function	biological_process	molecular_function	integral to membrane
YPL152W-A_p	YPL152W-A	YPL152W-A	hom	Uncharacterized	0.542731315008469	0.29365740500156	no	1357	0.282759010994035	985	NA					Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching	biological_process	molecular_function	cellular_component
YNL052W	YNL052W	COX5A	hom	Verified	0.54242985701836	0.293761208044751	no	1358	0.277050358142187	940	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Subunit Va of cytochrome c oxidase; cytochrome c oxidase is the terminal member of the mitochondrial inner membrane electron transport chain; Cox5Ap is predominantly expressed during aerobic growth while its isoform Vb (Cox5Bp) is expressed during anaerobic growth; COX5A has a paralog, COX5B, that arose from the whole genome duplication	mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity	mitochondrion|integral to membrane|mitochondrial respiratory chain complex IV
YOR279C	YOR279C	RFM1	hom	Verified	0.542134920646848	0.29386278188386	no	1359	0.324522382561916	1121	NA	FT	GENE SILENCING	NUCLEUS		DNA-binding protein required for vegetative repression of middle sporulation genes; specificity factor that directs the Hst1p histone deacetylase to some of the promoters regulated by Sum1p; involved in telomere maintenance	chromatin silencing|chromatin silencing at silent mating-type cassette	unfolded protein binding	histone deacetylase complex|nucleus
YNL154C	YNL154C	YCK2	hom	Verified	0.541871395715518	0.293953551602295	no	1360	0.301226023542554	1049	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CELL DIVISION|PROTEIN PHOSPHORYLATION	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Palmitoylated plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck1p in morphogenesis, proper septin assembly, endocytic trafficking; YCK2 has a paralog, YCK1, that arose from the whole genome duplication	endocytosis|cell morphogenesis|protein phosphorylation|cytokinesis|response to glucose stimulus	protein serine/threonine kinase activity|protein kinase activity	plasma membrane|cellular bud neck|mating projection
YBR229C	YBR229C	ROT2	hom	Verified	0.541720476172903	0.294005540849489	no	1361	0.292118447738069	981	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	ENDOPLASMIC RETICULUM|MITOCHONDRION		Glucosidase II catalytic subunit required for normal cell wall synthesis; mutations in rot2 suppress tor2 mutations, and are synthetically lethal with rot1 mutations	fungal-type cell wall biogenesis	alpha-glucosidase activity	glucosidase II complex|mitochondrion|endoplasmic reticulum|endoplasmic reticulum lumen
YLR025W	YLR025W	SNF7	hom	Verified	0.541612599984047	0.294042704989466	no	1362	0.352972119206778	1196	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|PROTEOLYSIS|VACUOLAR TRANSPORT			One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; recruited from the cytoplasm to endosomal membranes	cellular response to anoxia|intralumenal vesicle formation|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|late endosome to vacuole transport	protein binding	ESCRT III complex|cytoplasm
YHR181W	YHR181W	SVP26	hom	Verified	0.539185695438353	0.294879364799644	no	1363	0.285576731604639	991	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Integral membrane protein of the early Golgi apparatus and endoplasmic reticulum, involved in COP II vesicle transport; may also function to promote retention of proteins in the early Golgi compartment	protein retention in Golgi apparatus|fungal-type cell wall organization|protein glycosylation|ER to Golgi vesicle-mediated transport	COPII adaptor activity	integral to endoplasmic reticulum membrane|integral to membrane|endoplasmic reticulum|integral to Golgi membrane|ER to Golgi transport vesicle
YNL322C	YNL322C	KRE1	hom	Verified	0.538679798443251	0.295053907652734	no	1364	0.313729291216642	1085	NA	FT	CELL WALL ORG/BIOGENESIS	PLASMA MEMBRANE		Cell wall glycoprotein involved in beta-glucan assembly; serves as a K1 killer toxin membrane receptor	fungal-type cell wall organization	structural constituent of cell wall	fungal-type cell wall|integral to membrane
YJL212C	YJL212C	OPT1	hom	Verified	0.536923555067817	0.295660209775814	no	1365	0.292404567796788	997	NA	FT	PROTEIN LOCALIZATION	PLASMA MEMBRANE		Proton-coupled oligopeptide transporter of the plasma membrane; also transports glutathione and phytochelatin; member of the OPT family	oligopeptide transport|sulfur compound metabolic process	oligopeptide transporter activity|proton-dependent oligopeptide secondary active transmembrane transporter activity	integral to membrane|integral to plasma membrane
YDL090C	YDL090C	RAM1	hom	Verified	0.536256505380819	0.295890643101182	no	1366	0.347408810201876	1170	NA	FF|FT	PROTEIN PRENYLATION			Beta subunit of the CAAX farnesyltransferase (FTase) that prenylates the a-factor mating pheromone and Ras proteins; required for the membrane localization of Ras proteins and a-factor; homolog of the mammalian FTase beta subunit	protein farnesylation	protein farnesyltransferase activity	protein farnesyltransferase complex
YGL019W	YGL019W	CKB1	hom	Verified	0.535579454311791	0.296124615725167	no	1367	0.32641964925264	1095	NA	FF|FT	RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION	NUCLEUS		Beta regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases	regulation of transcription from RNA polymerase I promoter|protein phosphorylation|regulation of transcription from RNA polymerase III promoter|response to DNA damage stimulus	protein kinase regulator activity|protein serine/threonine kinase inhibitor activity	protein kinase CK2 complex|UTP-C complex
YBR180W	YBR180W	DTR1	hom	Verified	0.534153155120646	0.296617788128173	no	1368	0.29321001951138	977	NA	FT	CELL WALL ORG/BIOGENESIS			Putative dityrosine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; required for spore wall synthesis; expressed during sporulation	ascospore wall assembly|amine transport|transmembrane transport	amine transmembrane transporter activity	integral to membrane|prospore membrane
YKL105C	YKL105C	SEG2	hom	Verified	0.534072209172406	0.296645788139487	no	1369	0.283810377938671	962	NA					Eisosome component and paralog of Seg1p; likely plays only minor role in eisosome assembly; shown to interact with Seg1p; similar to A. gossypii SEG gene which is important for stabilizing eisosomes	biological_process	molecular_function	cellular_component
YMR312W	YMR312W	ELP6	hom	Verified	0.533869761259332	0.296715822192342	no	1370	0.299696798789162	1021	NA	FT	TRANSCRIPTION FROM RNA POL II|RNA PROCESSING	NUCLEUS		Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity	protein urmylation|regulation of transcription from RNA polymerase II promoter|tRNA wobble uridine modification	ATPase activity|tRNA binding	Elongator holoenzyme complex
YER142C	YER142C	MAG1	hom	Verified	0.532923731960888	0.297043188232893	no	1371	0.275393022664533	943	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		3-methyl-adenine DNA glycosylase; involved in protecting DNA against alkylating agents; initiates base excision repair by removing damaged bases to create abasic sites that are subsequently repaired; protein abundance increases in response to DNA replication stress	base-excision repair, AP site formation|DNA dealkylation involved in DNA repair	alkylbase DNA N-glycosylase activity	nucleus
YMR258C	YMR258C	ROY1	hom	Verified	0.532537879217971	0.297176756967108	no	1372	0.303774287186137	1061	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|NUCLEOTIDE METABOLISM|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM|NUCLEUS		GTPase inhibitor with similarity to F-box proteins; inhibits Ypt52p GTPase activity by preventing Ypt52p from binding GTP; involved in regulating intracellular trafficking; physically interacts with Skp1p	endocytosis|protein targeting to vacuole|negative regulation of GTPase activity	GTPase inhibitor activity	nucleus|cytoplasm
YHR017W	YHR017W	YSC83	hom	Verified	0.532037974864606	0.297349847198549	no	1373	0.319411762608118	1111	NA	FT		MITOCHONDRION		Non-essential mitochondrial protein of unknown function; mRNA induced during meiosis, peaking between mid to late prophase of meiosis I; similar to S. douglasii YSD83	biological_process	molecular_function	mitochondrial outer membrane|mitochondrion
YOR248W_d	YOR248W	YOR248W	hom	Dubious	0.530042693350279	0.29804116515587	no	1374	0.292052025466415	986	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDR467C_d	YDR467C	YDR467C	hom	Dubious	0.527840383609023	0.298805062731353	no	1375	0.302420851665136	1013	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YOR138C	YOR138C	RUP1	hom	Verified	0.525850302372191	0.299496110588569	no	1376	0.312780481608882	1047	NA	FT		NUCLEUS		Protein that regulates Rsp5p, which is a HECT ubiquitin ligase; has a WW domain consensus motif of PPPSY (residues 131-135) that mediates binding of Rsp5p to Ubp2p; contains an UBA domain; relative distribution to the nucleus increases upon DNA replication stress	protein deubiquitination	protein binding	nucleus|cytoplasm
YOL035C_d	YOL035C	YOL035C	hom	Dubious	0.525149381422129	0.299739675022524	no	1377	0.290276275943613	992	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YER060W	YER060W	FCY21	hom	Verified	0.524843327932483	0.29984605429679	no	1378	0.293685696715966	1008	NA					Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function	transmembrane transport	nucleobase transmembrane transporter activity	integral to membrane
YBR085W	YBR085W	AAC3	hom	Verified	0.524287928391022	0.300039145890981	no	1379	0.286870306244569	971	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Mitochondrial inner membrane ADP/ATP translocator; exchanges cytosolic ADP for mitochondrially synthesized ATP; expressed under anaerobic conditions; similar to Aac1p; has roles in maintenance of viability and in respiration; AAC3 has a paralog, PET9, that arose from the whole genome duplication	heme biosynthetic process|heme transport|anaerobic respiration|transmembrane transport	ATP:ADP antiporter activity	mitochondrion|integral to membrane|mitochondrial inner membrane
YDR020C_p	YDR020C	DAS2	hom	Uncharacterized	0.524239274523548	0.300056063695787	no	1380	0.277923214739085	948	NA	FT	NUCLEOTIDE METABOLISM	NUCLEUS		Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; weak similarity with uridine kinases and with phosphoribokinases	biological_process	molecular_function	nucleus|cytoplasm
YNL288W	YNL288W	CAF40	hom	Verified	0.522648308013913	0.300609508301512	no	1381	0.302487841899483	1023	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Evolutionarily conserved subunit of the CCR4-NOT complex involved in controlling mRNA initiation, elongation and degradation; binds Cdc39p	positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter	molecular_function	CCR4-NOT core complex
YCR063W	YCR063W	BUD31	hom	Verified	0.522415248451086	0.300690620696951	no	1382	0.272710294997739	924	NA	FT	CELL CYCLE|RNA PROCESSING|CELL DIVISION	NUCLEUS		Component of the SF3b subcomplex of the U2 snRNP; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; facilitates passage through G1/S Start, but is not required for G2/M transition or exit from mitosis	RNA splicing|mRNA splicing, via spliceosome|cellular bud site selection	molecular_function	U2 snRNP|nucleus
YER162C	YER162C	RAD4	hom	Verified	0.522146774238134	0.300784070797083	no	1383	0.301559623077628	1040	NA	FT	RESPONSE TO DNA DAMAGE|PROTEOLYSIS	NUCLEUS		Protein that recognizes and binds damaged DNA (with Rad23p) during nucleotide excision repair; subunit of Nuclear Excision Repair Factor 2 (NEF2); also involved, with Rad23p, in turnover of ubiquitylated proteins	proteasomal ubiquitin-dependent protein catabolic process|nucleotide-excision repair	damaged DNA binding	cytosol|nucleotide-excision repair factor 2 complex|nucleus
YPL145C	YPL145C	KES1	hom	Verified	0.520510160716078	0.301354023944745	no	1384	0.307241404002948	1015	NA	FT	VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|MEMBRANE ORGANIZATION	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		One of seven members of the yeast oxysterol binding protein family; involved in negative regulation of Sec14p-dependent Golgi complex secretory functions, peripheral membrane protein that localizes to the Golgi complex; KES1 has a paralog, HES1, that arose from the whole genome duplication	post-Golgi vesicle-mediated transport|positive regulation of phosphatase activity|maintenance of cell polarity|endocytosis|exocytosis|sterol transport	phosphatidic acid binding|lipid binding|phosphatidylinositol-4,5-bisphosphate binding|oxysterol binding|sterol transporter activity|phosphatidylinositol-4-phosphate binding	Golgi membrane|extrinsic to membrane|cytoplasm
YLR043C	YLR043C	TRX1	hom	Verified	0.520146956823451	0.301480576151229	no	1385	0.298697563971959	1032	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|RESPONSE TO OXIDATIVE STRESS	ENDOMEMBRANE SYSTEM|NUCLEUS|GOLGI APPARATUS		Cytoplasmic thioredoxin isoenzyme; part of the thioredoxin system which protects cells against oxidative and reductive stress; forms LMA1 complex with Pbi2p; acts as a cofactor for Tsa1p, required for ER-Golgi transport and vacuole inheritance; protein abundance increases in response to DNA replication stress	vacuole inheritance|regulation of DNA replication|cell redox homeostasis|protein deglutathionylation|retrograde vesicle-mediated transport, Golgi to ER|cellular response to oxidative stress|ER to Golgi vesicle-mediated transport|vacuole fusion, non-autophagic	disulfide oxidoreductase activity	cytosol|fungal-type vacuole
YBR208C	YBR208C	DUR1,2	hom	Verified	0.518157846343206	0.302174071519715	no	1386	0.292546041097034	978	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Urea amidolyase; contains both urea carboxylase and allophanate hydrolase activities, degrades urea to CO2 and NH3; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation; protein abundance increases in response to DNA replication stress	allantoin catabolic process|urea catabolic process	urea carboxylase activity|allophanate hydrolase activity	cytoplasm
YKL217W	YKL217W	JEN1	hom	Verified	0.517004513161432	0.302576504162355	no	1387	0.289788594311779	1008	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION|PLASMA MEMBRANE		Monocarboxylate/proton symporter of the plasma membrane; transport activity is dependent on the pH gradient across the membrane; mediates high-affinity uptake of carbon sources lactate, pyuvate, and acetate, and also of the micronutrient selenite, whose structure mimics that of monocarboxylates; expression and localization are tightly regulated, with transcription repression, mRNA degradation, and protein endocytosis and degradation all occurring in the presence of glucose	plasma membrane lactate transport|plasma membrane selenite transport|plasma membrane pyruvate transport	selenite:hydrogen symporter activity|secondary active monocarboxylate transmembrane transporter activity	mitochondrion|integral to membrane|plasma membrane
YGL219C	YGL219C	MDM34	hom	Verified	0.516880092522058	0.30261993261738	no	1388	0.341693621866197	1129	NA	FT	MITOCHONDRION ORGANIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION		Mitochondrial component of the ERMES complex that links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth	mitochondrion organization|phospholipid transport	molecular_function	mitochondrial outer membrane|ERMES complex|mitochondrion|cytoplasm
YDL107W	YDL107W	MSS2	hom	Verified	0.516715007903369	0.302677558959694	no	1389	0.30918659788915	1067	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Peripherally bound inner membrane protein of the mitochondrial matrix involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18p	protein insertion into mitochondrial membrane from inner side	molecular_function	extrinsic to mitochondrial inner membrane|mitochondrial matrix
YNL084C	YNL084C	END3	hom	Verified	0.516512096565943	0.302748396267374	no	1390	0.330982080197558	1153	NA	FF|FT	VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS|CELL DIVISION|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON		EH domain-containing protein involved in endocytosis, actin cytoskeletal organization and cell wall morphogenesis; forms a complex with Sla1p and Pan1p	bipolar cellular bud site selection|ascospore wall assembly|endocytosis|actin filament organization|cytokinesis|actin cortical patch assembly	protein binding, bridging	mating projection tip|actin cortical patch
YKL098W	YKL098W	MTC2	hom	Verified	0.516290640401304	0.302825716135301	no	1391	0.342525917596506	1154	NA					Protein of unknown function; mtc2 is synthetically sick with cdc13-1	biological_process	molecular_function	cellular_component
YOL030W	YOL030W	GAS5	hom	Verified	0.515655855503857	0.303047395814962	no	1392	0.301994109205698	1034	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM			1,3-beta-glucanosyltransferase, has similarity to Gas1p; localizes to the cell wall	(1->3)-beta-D-glucan metabolic process	1,3-beta-glucanosyltransferase activity	fungal-type cell wall|integral to membrane
YNL187W	YNL187W	SWT21	hom	Verified	0.515425857110389	0.303127733804315	no	1393	0.298447641630065	1051	NA	FT	RNA PROCESSING	NUCLEUS		Protein involved in mRNA splicing; contains a consensus nuclear export signal (NES) sequence similar to the consensus sequence recognized by Crm1p; interacts genetically with Prp40p and Tgs1p; contains WD40 repeats	mRNA splicing, via spliceosome	molecular_function	small nuclear ribonucleoprotein complex|nucleus
YER077C_p	YER077C	YER077C	hom	Uncharacterized	0.514671989665933	0.303391124983931	no	1394	0.334324188085479	1138	NA	FT		MITOCHONDRION		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; null mutation results in a decrease in plasma membrane electron transport	biological_process	molecular_function	mitochondrion
YDL169C	YDL169C	UGX2	hom	Verified	0.513794983199892	0.30369766790117	no	1395	0.305632431244515	1048	NA					Protein of unknown function, transcript accumulates in response to any combination of stress conditions	biological_process	molecular_function	cellular_component
YER101C	YER101C	AST2	hom	Verified	0.513614167763114	0.303760886092364	no	1396	0.310048264500133	1057	NA	FT	PROTEIN LOCALIZATION|OXIDATION-REDUCTION PROCESS			Lipid raft associated protein; overexpression restores Pma1p localization to lipid rafts which is required for targeting of Pma1p to the plasma membrane; sometimes classified in the medium-chain dehydrogenase/reductases (MDRs) superfamily; AST2 has a paralog, AST1, that arose from the whole genome duplication	protein targeting to membrane	molecular_function	cytoplasm
YJR054W	YJR054W	KCH1	hom	Verified	0.511817962698976	0.304389208804007	no	1397	0.291544627114593	973	NA					Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate	biological_process	molecular_function	integral to membrane|fungal-type vacuole
YMR306W	YMR306W	FKS3	hom	Verified	0.511283257853111	0.304576363279734	no	1398	0.314453818246077	1071	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	MITOCHONDRION|PLASMA MEMBRANE		Protein involved in spore wall assembly, has similarity to 1,3-beta-D-glucan synthase catalytic subunits Fks1p and Gsc2p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	ascospore wall assembly	1,3-beta-D-glucan synthase activity	mitochondrion|integral to membrane
YJL121C	YJL121C	RPE1	hom	Verified	0.510904201100142	0.304709069657281	no	1399	0.327132737688146	1127	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS			D-ribulose-5-phosphate 3-epimerase, catalyzes a reaction in the non-oxidative part of the pentose-phosphate pathway; mutants are sensitive to oxidative stress	pentose-phosphate shunt	ribulose-phosphate 3-epimerase activity	cytosol
YPR192W	YPR192W	AQY1	hom	Verified	0.508597042478727	0.305517351220227	no	1400	0.283725162394741	982	NA	FT		PLASMA MEMBRANE		Spore-specific water channel that mediates the transport of water across cell membranes, developmentally controlled; may play a role in spore maturation, probably by allowing water outflow, may be involved in freeze tolerance	ascospore formation|water transport	water channel activity	integral to membrane|plasma membrane
YOL029C_p	YOL029C	YOL029C	hom	Uncharacterized	0.507513086296759	0.30589742835368	no	1401	0.290988576527889	1011	NA					Putative protein of unknown function; identified as interacting with Hsc82p and Hsp82p in high-throughput two-hybrid screens	biological_process	molecular_function	cellular_component
YIL093C	YIL093C	RSM25	hom	Verified	0.507022729017644	0.306069435385861	no	1402	0.312419920633914	1073	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the small subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YNL082W	YNL082W	PMS1	hom	Verified	0.506306599767744	0.306320715315979	no	1403	0.30841984364144	1029	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS		ATP-binding protein required for mismatch repair in mitosis and meiosis; functions as a heterodimer with Mlh1p, binds double- and single-stranded DNA via its N-terminal domain, similar to E. coli MutL	mismatch repair|meiotic mismatch repair	double-stranded DNA binding|DNA insertion or deletion binding|loop DNA binding|single-stranded DNA binding|dinucleotide insertion or deletion binding|ATPase activity|ATP binding	nucleus|MutLalpha complex|cytoplasm
YER062C	YER062C	HOR2	hom	Verified	0.503705661591791	0.307234114636297	no	1404	0.284734425511224	952	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS		Glycerol-1-phosphatase involved in glycerol biosynthesis; induced in response to hyperosmotic or oxidative stress, and during diauxic shift; HOR2 has a paralog, RHR2, that arose from the whole genome duplication	cellular carbohydrate metabolic process|glycerol biosynthetic process|response to osmotic stress	glycerol-1-phosphatase activity	nucleus|cytoplasm
YJL115W	YJL115W	ASF1	hom	Verified	0.503647342140502	0.307254609045691	no	1405	0.276143859317045	940	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS		Nucleosome assembly factor, involved in chromatin assembly and disassembly, anti-silencing protein that causes derepression of silent loci when overexpressed; plays a role in regulating Ty1 transposition	DNA replication-independent nucleosome assembly|histone acetylation|nucleosome disassembly|histone exchange|positive regulation of histone acetylation|chromatin silencing at silent mating-type cassette|chromatin silencing at telomere|DNA replication-dependent nucleosome assembly|regulation of transcription from RNA polymerase II promoter in response to stress	histone binding	chromatin assembly complex
YDL069C	YDL069C	CBS1	hom	Verified	0.503525433413434	0.307297451711353	no	1406	0.314261063018239	1079	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial translational activator of the COB mRNA; membrane protein that interacts with translating ribosomes, acts on the COB mRNA 5'-untranslated leader	mitochondrial respiratory chain complex III biogenesis|positive regulation of mitochondrial translation	translation regulator activity	extrinsic to mitochondrial inner membrane|mitochondrion|mitochondrial ribosome
YGR057C	YGR057C	LST7	hom	Verified	0.502793313424464	0.307554797636602	no	1407	0.362668231672909	1194	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM		Protein possibly involved in a post-Golgi secretory pathway; required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface	intracellular protein transport|vesicle-mediated transport|protein transport|Golgi to plasma membrane transport	protein transporter activity	vesicle coat
YIL096C_p	YIL096C	YIL096C	hom	Uncharacterized	0.502122451870119	0.307790693931296	no	1408	0.301927777952224	1011	NA	FT		NUCLEUS		Putative S-adenosylmethionine-dependent methyltransferase; associates with precursors of the 60S ribosomal subunit; predicted to be involved in ribosome biogenesis	biological_process	S-adenosylmethionine-dependent methyltransferase activity	nucleolus|nucleus
YIL014C-A_p	YIL014C-A	YIL014C-A	hom	Uncharacterized	0.501917665185586	0.307862719290634	no	1409	0.315929954199764	1072	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YEL025C_p	YEL025C	YEL025C	hom	Uncharacterized	0.501755967042252	0.307919595244894	no	1410	0.274194958017263	921	NA	FT		NUCLEUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus	biological_process	molecular_function	nucleus|cytoplasm
YKR041W	YKR041W	YKR041W	hom	Verified	0.501327388396192	0.308070366480654	no	1411	0.293167508668184	966	NA	FT		NUCLEUS|CYTOSKELETON		Protein of unknown function; localizes to the mitotic spindle; overexpression of YKR041W affects endocytic protein trafficking	biological_process	molecular_function	nucleus|mitotic spindle|cytoplasm
YDL072C	YDL072C	YET3	hom	Verified	0.500975581143007	0.308194154243231	no	1412	0.305965388625034	1053	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein of unknown function; YET3 null mutant decreases the level of secreted invertase; homolog of human BAP31 protein; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	integral to membrane|endoplasmic reticulum
YEL050C	YEL050C	RML2	hom	Verified	0.500395506289497	0.308398308445634	no	1413	0.340020551012421	1127	NA	FF|FT	KETONE METABOLISM|LIPID METABOLISM|TRANSLATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L2 ribosomal protein; fat21 mutant allele causes inability to utilize oleate and may interfere with activity of the Adr1p transcription factor	cytoplasmic translation|fatty acid metabolic process	structural constituent of ribosome	mitochondrial large ribosomal subunit
YDR270W	YDR270W	CCC2	hom	Verified	0.50033471467266	0.308419707157848	no	1414	0.338288048921321	1146	NA	FF|FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Cu(+2)-transporting P-type ATPase; required for export of copper from the cytosol into an extracytosolic compartment; has similarity to human proteins involved in Menkes and Wilsons diseases; protein abundance increases in response to DNA replication stress; affects TBSV model (+)RNA virus replication by regulating copper metabolism	cellular iron ion homeostasis|copper ion export|transmembrane transport	copper ion binding|cation-transporting ATPase activity	integral to membrane|trans-Golgi network transport vesicle membrane
YLR180W	YLR180W	SAM1	hom	Verified	0.499770114070252	0.308618478241874	no	1415	0.295776895520566	975	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM			S-adenosylmethionine synthetase; catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; SAM1 has a paralog, SAM2, that arose from the whole genome duplication	methionine metabolic process|S-adenosylmethionine biosynthetic process	methionine adenosyltransferase activity	cytoplasm
YMR116C	YMR116C	ASC1	hom	Verified	0.499693518343397	0.308645448556762	no	1416	0.309678080353448	1050	NA	FT	SIGNALING|TRANSLATION		RIBOSOME	G-protein beta subunit and guanine nucleotide dissociation inhibitor for Gpa2p; ortholog of RACK1 that inhibits translation; core component of the small (40S) ribosomal subunit; regulates P-body formation induced by replication stress; represses Gcn4p in the absence of amino acid starvation	negative regulation of translation|glucose mediated signaling pathway|G-protein coupled receptor signaling pathway|invasive growth in response to glucose limitation	G-protein alpha-subunit binding|GDP-dissociation inhibitor activity|signal transducer activity	cytosolic small ribosomal subunit|cytoplasm
YGL161C	YGL161C	YIP5	hom	Verified	0.499692550897565	0.308645789213159	no	1417	0.311364546323592	1052	NA	FT		GOLGI APPARATUS		Protein that interacts with Rab GTPases, localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport	biological_process	Rab GTPase binding	integral to membrane|Golgi apparatus
YJL077W-B_p	YJL077W-B	YJL077W-B	hom	Uncharacterized	0.498407277785017	0.309098504091778	no	1418	0.359808518125107	1205	NA					Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching	biological_process	molecular_function	cellular_component
YGR285C	YGR285C	ZUO1	hom	Verified	0.498064278703883	0.309219368555832	no	1419	0.30485860568025	1049	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION	NUCLEUS|MITOCHONDRION	RIBOSOME	Ribosome-associated chaperone, functions in ribosome biogenesis and, in partnership with Ssz1p and SSb1/2, as a chaperone for nascent polypeptide chains; contains a DnaJ domain and functions as a J-protein partner for Ssb1p and Ssb2p	protein folding|ribosomal subunit export from nucleus|rRNA processing|regulation of translational fidelity	unfolded protein binding	mitochondrion|ribosome|nucleolus|polysome|cytoplasm
YPL003W	YPL003W	ULA1	hom	Verified	0.496523752404485	0.3097624667355	no	1420	0.313386192148094	1069	NA					Protein that acts together with Uba3p to activate Rub1p before its conjugation to proteins (neddylation), which may play a role in protein degradation	protein neddylation	NEDD8 activating enzyme activity	cellular_component
YGL076C	YGL076C	RPL7A	hom	Verified	0.496183081693725	0.309882623163313	no	1421	0.289764630278489	971	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L7A; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2); homologous to mammalian ribosomal protein L7 and bacterial L30; RPL7A has a paralog, RPL7B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit|cytoplasm
YDR511W	YDR511W	ACN9	hom	Verified	0.493737353884176	0.31074584050199	no	1422	0.27090310344518	941	NA	FT	KETONE METABOLISM|CARBOHYDRATE METABOLISM	MITOCHONDRION		Protein of the mitochondrial intermembrane space, required for acetate utilization and gluconeogenesis; has orthologs in higher eukaryotes	carbon utilization|regulation of gluconeogenesis	molecular_function	mitochondrion|mitochondrial intermembrane space
YCR099C_p	YCR099C	YCR099C	hom	Uncharacterized	0.493268507666121	0.310911438592299	no	1423	0.346309012246986	1169	NA					Putative protein of unknown function	biological_process	molecular_function	integral to membrane
YPR057W	YPR057W	BRR1	hom	Verified	0.492958331389788	0.311021014969051	no	1424	0.251998570685488	876	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING	NUCLEUS		snRNP protein component of spliceosomal snRNPs, required for pre-mRNA splicing and snRNP biogenesis; in null mutant newly-synthesized snRNAs are destabilized and 3'-end processing is slowed	spliceosomal complex assembly	RNA binding	small nuclear ribonucleoprotein complex
YGL086W	YGL086W	MAD1	hom	Verified	0.492940612270456	0.31102727513141	no	1425	0.303524799893233	1019	NA	FT	CELL CYCLE|CELL DIVISION	ENDOMEMBRANE SYSTEM|NUCLEUS|CHROMOSOME	NUCLEAR PORE|KINETOCHORE	Coiled-coil protein involved in the spindle-assembly checkpoint; required for inhibition of karyopherin/importin Pse1p (aka Kap121p) upon spindle assembly checkpoint arrest; phosphorylated by Mps1p upon checkpoint activation which leads to inhibition of the activity of the anaphase promoting complex; forms a complex with Mad2p	nucleocytoplasmic transport|mitotic cell cycle spindle assembly checkpoint|mitotic cell cycle G2/M transition decatenation checkpoint	molecular_function	nucleus|nuclear pore|kinetochore
YPR064W_d	YPR064W	YPR064W	hom	Dubious	0.490993055091208	0.311715679769585	no	1426	0.304757220190829	1034	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YMR243C	YMR243C	ZRC1	hom	Verified	0.490805343942987	0.311782065012684	no	1427	0.314715082269539	1062	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Vacuolar membrane zinc transporter; transports zinc from cytosol to vacuole for storage; also has role in resistance to zinc shock resulting from sudden influx of zinc into cytoplasm; human ortholog SLC30A10 functions as a Mn transporter and mutations in SLC30A10 cause neurotoxic accumulation of Mn in liver and brain; ZRC1 has a paralog, COT1, that arose from the whole genome duplication	cobalt ion transport|cellular zinc ion homeostasis|zinc ion transport|glutathione metabolic process	zinc ion transmembrane transporter activity|inorganic cation transmembrane transporter activity	integral to membrane|fungal-type vacuole
YML012C-A_d	YML012C-A	YML012C-A	hom	Dubious	0.490607332783301	0.311852099549359	no	1428	0.319388478349093	1082	NA	FF				Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene SEL1	Unknown	Unknown	Unknown
YMR038C	YMR038C	CCS1	hom	Verified	0.490367325165544	0.31193699692813	no	1429	0.373048584570424	1252	NA	FF|FT	ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|RESPONSE TO OXIDATIVE STRESS	NUCLEUS|MITOCHONDRION		Copper chaperone for superoxide dismutase Sod1p; involved in oxidative stress protection; Met-X-Cys-X2-Cys motif within the N-terminal portion is involved in insertion of copper into Sod1p under conditions of copper deprivation; protein abundance increases in response to DNA replication stress	intracellular copper ion transport	superoxide dismutase copper chaperone activity	cytosol|mitochondrial inner membrane|nucleus
YGL078C	YGL078C	DBP3	hom	Verified	0.488672259046532	0.312536873301531	no	1430	0.319061406811892	1112	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		RNA-Dependent ATPase, member of DExD/H-box family; involved in cleavage of site A3 within the ITS1 spacer during rRNA processing; not essential for growth, but deletion causes severe slow-growth phenotype	endonucleolytic cleavage in ITS1 upstream of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	RNA-dependent ATPase activity	nucleolus|preribosome, large subunit precursor
YOR270C	YOR270C	VPH1	hom	Verified	0.488636281366012	0.312549611035023	no	1431	0.304248796620873	1011	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|ION HOMEOSTASIS			Subunit a of vacuolar-ATPase V0 domain; one of two isoforms (Vph1p and Stv1p); Vph1p is located in V-ATPase complexes of the vacuole while Stv1p is located in V-ATPase complexes of the Golgi and endosomes; relative distribution to the vacuolar membrane decreases upon DNA replication stress	polyphosphate metabolic process|proton transport|protein complex assembly|vacuolar acidification	proton-transporting ATPase activity, rotational mechanism	vacuolar proton-transporting V-type ATPase, V0 domain|fungal-type vacuole membrane|integral to membrane|fungal-type vacuole
YML051W	YML051W	GAL80	hom	Verified	0.48856248967704	0.312575737346172	no	1432	0.310443757824682	1035	NA	FT	TRANSCRIPTION FROM RNA POL II|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM	NUCLEUS		Transcriptional regulator involved in the repression of GAL genes in the absence of galactose; inhibits transcriptional activation by Gal4p; inhibition relieved by Gal3p or Gal1p binding	negative regulation of kinase activity|galactose metabolic process|negative regulation of transcription from RNA polymerase II promoter|negative regulation of sequence-specific DNA binding transcription factor activity	RNA polymerase II activating transcription factor binding|kinase inhibitor activity	nucleus|cytoplasm
YDL081C	YDL081C	RPP1A	hom	Verified	0.487198078970059	0.313058983287659	no	1433	0.308906204313328	1028	NA	FT	TRANSLATION		RIBOSOME	Ribosomal stalk protein P1 alpha, involved in the interaction between translational elongation factors and the ribosome; accumulation of P1 in the cytoplasm is regulated by phosphorylation and interaction with the P2 stalk component	cytoplasmic translation|translational elongation	structural constituent of ribosome	cytosolic large ribosomal subunit
YJR034W	YJR034W	PET191	hom	Verified	0.487037380337113	0.31311592057218	no	1434	0.322935350494576	1088	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Protein required for assembly of cytochrome c oxidase; exists as an oligomer; described as both an integral mitochondrial inner membrane protein facing the intermembrane space (IMS) and as a soluble IMS protein; contains a twin Cx9C motif; imported into the IMS via the MIA import machinery	mitochondrial respiratory chain complex IV assembly	molecular_function	mitochondrion|integral to mitochondrial inner membrane
YEL054C	YEL054C	RPL12A	hom	Verified	0.487036903745724	0.313116089440354	no	1435	0.302893236788856	1020	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L12A; rpl12a rpl12b double mutant exhibits slow growth and slow translation; homologous to mammalian ribosomal protein L12 and bacterial L11; RPL12A has a paralog, RPL12B, that arose from the whole genome duplication	cytoplasmic translation|ribosomal large subunit assembly	structural constituent of ribosome	cytosolic large ribosomal subunit
YER048C	YER048C	CAJ1	hom	Verified	0.48688418367554	0.313170203975385	no	1436	0.302154115376092	1001	NA	FT		NUCLEUS		Nuclear type II J heat shock protein of the E. coli dnaJ family, contains a leucine zipper-like motif, binds to non-native substrates for presentation to Ssa3p, may function during protein translocation, assembly and disassembly	protein folding	chaperone binding	nucleus
YFL053W	YFL053W	DAK2	hom	Verified	0.486018486390939	0.313477029506611	no	1437	0.30216135774385	1013	NA	FT	CARBOHYDRATE METABOLISM			Dihydroxyacetone kinase, required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation	response to stress|glycerol catabolic process	glycerone kinase activity	cellular_component
YHR116W	YHR116W	COX23	hom	Verified	0.485627067642862	0.313615800844924	no	1438	0.313993698175766	1027	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial intermembrane space protein that functions in mitochondrial copper homeostasis, essential for functional cytochrome oxidase expression; homologous to Cox17p; contains twin cysteine-x9-cysteine motifs	mitochondrial respiratory chain complex assembly	molecular_function	mitochondrion|cytoplasm
YBL107C	YBL107C	MIC23	hom	Verified	0.485123344022047	0.313794426920876	no	1439	0.314881243214283	1078	NA					Mitochondrial intermembrane space protein of unknown function; imported via the MIA import machinery; contains an unusual twin cysteine motif (CX13C CX14C)	biological_process	molecular_function	cytoplasm
YMR075W	YMR075W	RCO1	hom	Verified	0.485122926581696	0.31379457496804	no	1440	0.320566226390588	1106	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION	NUCLEUS|CHROMOSOME		Essential subunit of the histone deacetylase Rpd3S complex; interacts with Eaf3p	regulation of DNA-dependent DNA replication initiation|negative regulation of antisense RNA transcription|transcription elongation from RNA polymerase II promoter|histone deacetylation	molecular_function	Rpd3S complex|histone deacetylase complex|nucleus|Rpd3L complex
YPL183C	YPL183C	RTT10	hom	Verified	0.483149563134804	0.314494772224381	no	1441	0.320608122979019	1082	NA	FT	VESICLE-MEDIATED TRANSPORT			WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rrt2p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; evidence it interacts with Trm7p for 2'-O-methylation of N34 of substrate tRNAs; has a role in regulation of Ty1 transposition; human ortholog is WDR6	endocytic recycling	molecular_function	endosome|cytoplasm
YJR053W	YJR053W	BFA1	hom	Verified	0.482616233724524	0.314684125182121	no	1442	0.289191752531301	972	NA	FT	CELL CYCLE|CELL DIVISION	CYTOSKELETON		Component of the GTPase-activating Bfa1p-Bub2p complex involved in multiple cell cycle checkpoint pathways that control exit from mitosis	regulation of exit from mitosis|mitotic cell cycle spindle orientation checkpoint	GTPase activator activity	spindle pole body
YER187W_p	YER187W	YER187W	hom	Uncharacterized	0.482469191572438	0.314736339514607	no	1443	0.297486368238825	991	NA					Putative protein of unknown function; induced in respiratory-deficient cells	biological_process	molecular_function	cellular_component
YHR179W	YHR179W	OYE2	hom	Verified	0.482439774601438	0.314746785858551	no	1444	0.325432762602398	1092	NA	FT	OXIDATION-REDUCTION PROCESS	NUCLEUS|MITOCHONDRION		Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN); responsible for geraniol reduction into citronellol during fermentation; homologous to Oye3p with different ligand binding and catalytic properties; may be involved in sterol metabolism, oxidative stress response, and programmed cell death; protein abundance increases in response to DNA replication stress	apoptotic process	NADPH dehydrogenase activity	mitochondrion|nucleus|cytoplasm
YKL047W_p	YKL047W	ANR2	hom	Uncharacterized	0.482338420821678	0.314782779021848	no	1445	0.313998280632892	1073	NA					Putative protein of unknown function, predicted to be palmitoylated; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	biological_process	molecular_function	cytoplasm
YNL049C	YNL049C	SFB2	hom	Verified	0.48221191023797	0.314827708439824	no	1446	0.302253111161204	1003	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Component of the Sec23p-Sfb2p heterodimer of the COPII vesicle coat, required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sec24p and Sfb3p	cargo loading into COPII-coated vesicle	signal sequence binding	COPII vesicle coat
YLR187W	YLR187W	SKG3	hom	Verified	0.481614634151506	0.315039864198853	no	1447	0.315337820475666	1038	NA	FT		SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; potential Cdc28p substrate; similar to Skg4p; relocalizes from bud neck to cytoplasm upon DNA replication stress; SKG3 has a paralog, CAF120, that arose from the whole genome duplication	biological_process	molecular_function	cellular bud|cellular bud neck|cytoplasm
YGR204W	YGR204W	ADE3	hom	Verified	0.480360227967162	0.315485634830844	no	1448	0.300661641225432	1009	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM	NUCLEUS		Cytoplasmic trifunctional enzyme C1-tetrahydrofolate synthase, involved in single carbon metabolism and required for biosynthesis of purines, thymidylate, methionine, and histidine; null mutation causes auxotrophy for adenine and histidine	purine nucleobase biosynthetic process|folic acid-containing compound metabolic process	methylenetetrahydrofolate dehydrogenase (NADP+) activity|formate-tetrahydrofolate ligase activity|methenyltetrahydrofolate cyclohydrolase activity	nucleus|cytoplasm
YOR363C	YOR363C	PIP2	hom	Verified	0.478984182188827	0.315974940791862	no	1449	0.306024837907633	1030	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS	NUCLEUS		Autoregulatory oleate-specific transcriptional activator of peroxisome proliferation, contains Zn(2)-Cys(6) cluster domain, forms heterodimer with Oaf1p, binds oleate response elements (OREs), activates beta-oxidation genes; PIP2 has a paralog, OAF1, that arose from the whole genome duplication	cellular response to oleic acid|positive regulation of fatty acid beta-oxidation|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	integral to membrane|nucleus
YCL049C_p	YCL049C	YCL049C	hom	Uncharacterized	0.478274094693337	0.316227565929371	no	1450	0.319356484789568	1085	NA					Protein of unknown function; localizes to membrane fraction; YCL049C is not an essential gene	biological_process	molecular_function	membrane
YLR357W	YLR357W	RSC2	hom	Verified	0.477764996896096	0.31640873854413	no	1451	0.325314555493439	1089	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION	NUCLEUS	RSC COMPLEX	Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; involved in telomere maintenance	ATP-dependent chromatin remodeling|chromosome segregation|nucleosome disassembly|plasmid maintenance|sister chromatid cohesion|double-strand break repair via nonhomologous end joining|transcription elongation from RNA polymerase II promoter|double-strand break repair via homologous recombination	DNA translocase activity	RSC complex
YMR205C	YMR205C	PFK2	hom	Verified	0.477303760135663	0.316572916906111	no	1452	0.436601050039874	1417	NA	FT	CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Beta subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes	proton transport|glycolysis	mRNA binding|6-phosphofructokinase activity	mitochondrion|6-phosphofructokinase complex|cytoplasm
YER161C	YER161C	SPT2	hom	Verified	0.477232611074896	0.31659824580848	no	1453	0.331972632081829	1128	NA	FT	TRANSCRIPTION FROM RNA POL II|RNA PROCESSING|CHROMATIN ORGANIZATION	NUCLEUS		Protein involved in negative regulation of transcription; required for RNA polyadenylation; exhibits regulated interactions with both histones and SWI-SNF components, has similarity to mammalian HMG1 proteins	negative regulation of transcription from RNA polymerase II promoter|chromatin organization|RNA polyadenylation|transcription elongation from RNA polymerase II promoter	DNA binding|DNA secondary structure binding	nucleus
YKL138C	YKL138C	MRPL31	hom	Verified	0.476139155557569	0.316987621580688	no	1454	0.322532930968317	1112	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation	structural constituent of ribosome	mitochondrial large ribosomal subunit
YPL080C_d	YPL080C	YPL080C	hom	Dubious	0.476100249984126	0.317001479460323	no	1455	0.280281762107967	933	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDL054C	YDL054C	MCH1	hom	Verified	0.475141612290098	0.31734302021429	no	1456	0.32193223247028	1115	NA					Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport	transport	monocarboxylic acid transmembrane transporter activity|transporter activity	integral to membrane|membrane
YNL275W	YNL275W	BOR1	hom	Verified	0.474704814191961	0.317498693035009	no	1457	0.309424583141756	1039	NA	FT	PROTEIN LOCALIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS|VACUOLAR TRANSPORT	PLASMA MEMBRANE		Boron efflux transporter of the plasma membrane; binds HCO3-, I-, Br-, NO3- and Cl-; has similarity to the characterized boron efflux transporter A. thaliana BOR1	borate transport|protein targeting to vacuole	borate efflux transmembrane transporter activity	integral to membrane|plasma membrane|fungal-type vacuole
YGR215W	YGR215W	RSM27	hom	Verified	0.474472771070251	0.317581405261107	no	1458	0.321716142804672	1091	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the small subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YNR012W	YNR012W	URK1	hom	Verified	0.473949022399163	0.31776812997324	no	1459	0.33236025876202	1146	NA	FT	NUCLEOTIDE METABOLISM	NUCLEUS		Uridine/cytidine kinase, component of the pyrimidine ribonucleotide salvage pathway that converts uridine into UMP and cytidine into CMP; involved in the pyrimidine deoxyribonucleotide salvage pathway, converting deoxycytidine into dCMP	pyrimidine-containing compound salvage	uridine kinase activity	nucleus|cytoplasm
YKL124W	YKL124W	SSH4	hom	Verified	0.473872023027782	0.317795585380456	no	1460	0.273981671169884	947	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEOLYSIS|VACUOLAR TRANSPORT			Specificity factor required for Rsp5p-dependent ubiquitination and sorting of cargo proteins at the multivesicular body; identified as a high-copy suppressor of a SHR3 deletion, increasing steady-state levels of amino acid permeases	protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|vesicle-mediated transport	molecular_function	fungal-type vacuole
YLR433C	YLR433C	CNA1	hom	Verified	0.47342524204248	0.317954912342455	no	1461	0.295084839165941	1032	NA	FT	SIGNALING|ION HOMEOSTASIS|CELL WALL ORG/BIOGENESIS|ION HOMEOSTASIS			Calcineurin A; one isoform (the other is CMP2) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1	adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion|fungal-type cell wall organization|cellular ion homeostasis	calcium-dependent protein serine/threonine phosphatase activity	calcineurin complex|cytoplasm
YOR068C	YOR068C	VAM10	hom	Verified	0.472135872016109	0.318414904624822	no	1462	0.323515549332274	1099	NA	FT	MEMBRANE ORGANIZATION			Protein involved in vacuole morphogenesis; acts at an early step of homotypic vacuole fusion that is required for vacuole tethering	vacuole fusion, non-autophagic	molecular_function	fungal-type vacuole membrane
YDL001W	YDL001W	RMD1	hom	Verified	0.471886522158919	0.318503894369874	no	1463	0.312043765681442	1081	NA	FT	CELL CYCLE			Cytoplasmic protein required for sporulation	biological_process	molecular_function	cytoplasm
YIL095W	YIL095W	PRK1	hom	Verified	0.471222358243561	0.318740976977777	no	1464	0.310646628783029	1048	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Protein serine/threonine kinase; regulates the organization and function of the actin cytoskeleton and reduces endocytic ability of cell through the phosphorylation of the Pan1p-Sla1p-End3p protein complex; PRK1 has a paralog, ARK1, that arose from the whole genome duplication	regulation of endocytosis|actin filament organization|protein phosphorylation|actin cortical patch assembly|cytokinesis	protein serine/threonine kinase activity|protein kinase activity	mating projection tip|actin cortical patch
YKL048C	YKL048C	ELM1	hom	Verified	0.470332952488132	0.319058579029658	no	1465	0.327790778997453	1119	NA	FT	CELL CYCLE|CELL DIVISION|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Serine/threonine protein kinase that regulates cellular morphogenesis, septin behavior, and cytokinesis; required for the regulation of other kinases, such as Kin4p; forms part of the bud neck ring	positive regulation of protein autophosphorylation|protein autophosphorylation|cell morphogenesis|budding cell bud growth|protein phosphorylation|response to drug|septin checkpoint|pseudohyphal growth|glucose metabolic process|axial cellular bud site selection|response to osmotic stress|cytokinesis	protein serine/threonine kinase activity|protein kinase activity	cellular bud neck contractile ring
YJL098W	YJL098W	SAP185	hom	Verified	0.469458900177786	0.319370827914214	no	1466	0.322217286131518	1078	NA	FT	CELL CYCLE|RNA PROCESSING	MITOCHONDRION		Protein that forms a complex with the Sit4p protein phosphatase; required for Sit4p function; member of a family of similar proteins including Sap4p, Sap155p, and Sap190p; SAP185 has a paralog, SAP190, that arose from the whole genome duplication	tRNA wobble uridine modification|G1/S transition of mitotic cell cycle	protein serine/threonine phosphatase activity	mitochondrion|cytoplasm
YKR067W	YKR067W	GPT2	hom	Verified	0.469201381826007	0.319462848937104	no	1467	0.332265506503538	1151	NA	FT	LIPID METABOLISM	ENDOPLASMIC RETICULUM		Glycerol-3-phosphate/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase located in lipid particles and the ER; involved in the stepwise acylation of glycerol-3-phosphate and dihydroxyacetone in lipid biosynthesis; the most conserved motifs and functionally relevant residues are oriented towards the ER lumen	phospholipid biosynthetic process	glycerol-3-phosphate O-acyltransferase activity|glycerone-phosphate O-acyltransferase activity	integral to membrane|lipid particle|endoplasmic reticulum|cytoplasm
YNL278W	YNL278W	CAF120	hom	Verified	0.468420879010457	0.319741819943392	no	1468	0.308019177717069	1017	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS|SITE OF POLARIZED GROWTH		Part of the CCR4-NOT transcriptional regulatory complex; involved in controlling mRNA initiation, elongation, and degradation; CAF120 has a paralog, SKG3, that arose from the whole genome duplication	regulation of transcription from RNA polymerase II promoter	molecular_function	CCR4-NOT complex
YLR113W	YLR113W	HOG1	hom	Verified	0.468276142554617	0.319793563548157	no	1469	0.350069962109024	1174	NA	FT	TRANSCRIPTION FROM RNA POL II|SIGNALING|PROTEIN PHOSPHORYLATION	NUCLEUS		Mitogen-activated protein kinase involved in osmoregulation; controls global reallocation of RNA Pol II in response to osmotic shock; acts via three independent osmosensors; mitophagy-specific regulator; mediates the recruitment and activation of RNA Pol II at Hot1p-dependent promoters; localization regulated by Ptp2p and Ptp3p; protein abundance increases in response to DNA replication stress	negative regulation of transcription from RNA polymerase II promoter by pheromones|protein phosphorylation|hyperosmotic response|response to arsenic-containing substance|osmosensory signaling pathway|positive regulation of transcription from RNA polymerase II promoter|cellular response to heat	MAP kinase activity	nucleus|cytoplasm
YOL119C	YOL119C	MCH4	hom	Verified	0.466508306197765	0.320425851746278	no	1470	0.297274023553478	974	NA					Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport	transport	monocarboxylic acid transmembrane transporter activity|transporter activity	fungal-type vacuole membrane|integral to membrane
YDR466W	YDR466W	PKH3	hom	Verified	0.466180628627406	0.320543106973697	no	1471	0.360191126596742	1226	NA	FF|FT	SIGNALING|CELL WALL ORG/BIOGENESIS|PROTEIN PHOSPHORYLATION			Protein kinase with similarity to mammalian phosphoinositide-dependent kinase 1 (PDK1) and yeast Pkh1p and Pkh2p, two redundant upstream activators of Pkc1p; identified as a multicopy suppressor of a pkh1 pkh2 double mutant	MAPK cascade involved in cell wall biogenesis|protein phosphorylation	protein kinase activity	cellular_component
YPR087W_d	YPR087W	VPS69	hom	Dubious	0.465206483998578	0.320891797914633	no	1472	0.338695764462269	1128	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 85% of ORF overlaps the verified gene SRP54; deletion causes a vacuolar protein sorting defect	Unknown	Unknown	Unknown
YDL037C	YDL037C	BSC1	hom	Verified	0.464214261102017	0.321247122375247	no	1473	0.316695966873281	1082	NA					Protein of unconfirmed function, similar to cell surface flocculin Flo11p; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression	biological_process	molecular_function	cellular_component
YHR168W	YHR168W	MTG2	hom	Verified	0.463523580343216	0.321494558379911	no	1474	0.314486216324914	1073	NA	FT	TRANSLATION|NUCLEOTIDE METABOLISM	MITOCHONDRION		Putative GTPase, member of the Obg family; peripheral protein of the mitochondrial inner membrane that associates with the large ribosomal subunit; required for mitochondrial translation, possibly via a role in ribosome assembly	cytoplasmic translation	ribosome binding|GTPase activity	mitochondrial inner membrane|extrinsic to membrane
YGR055W	YGR055W	MUP1	hom	Verified	0.463333091954424	0.321562814683885	no	1475	0.323115014885357	1070	NA	FT		PLASMA MEMBRANE		High affinity methionine permease, integral membrane protein with 13 putative membrane-spanning regions; also involved in cysteine uptake	cysteine transport|sulfur amino acid transport|methionine transport	L-methionine secondary active transmembrane transporter activity	integral to membrane|integral to plasma membrane
YDR186C	YDR186C	YDR186C	hom	Verified	0.462697787308852	0.321790502268311	no	1476	0.304783186297916	1046	NA					Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	biological_process	molecular_function	ribosome|cytoplasm
YNL242W	YNL242W	ATG2	hom	Verified	0.462612659525843	0.321821016402608	no	1477	0.314289960414853	1056	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS|PEROXISOME ORGANIZATION			Peripheral membrane protein required for autophagic vesicle formation; also required for vesicle formation during pexophagy and the cytoplasm-to-vaucole targeting (Cvt) pathway; involved in Atg9p cycling between the phagophore assembly site and mitochondria; forms cytoplasmic foci upon DNA replication stress	mitochondrion degradation|piecemeal microautophagy of nucleus|peroxisome degradation|CVT pathway|autophagic vacuole assembly	molecular_function	pre-autophagosomal structure|cytoplasm|extrinsic to membrane
YOL072W	YOL072W	THP1	hom	Verified	0.461863870584279	0.322089472260669	no	1478	0.370724052828879	1233	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|RNA PROCESSING|RESPONSE TO DNA DAMAGE|CELL DIVISION|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	Nuclear pore-associated protein; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; contains a PAM domain implicated in protein-protein binding	mRNA export from nucleus|mRNA 3'-end processing|transcription-coupled nucleotide-excision repair|cellular bud site selection|nuclear retention of pre-mRNA at the site of transcription|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|transcription elongation from RNA polymerase II promoter	double-stranded DNA binding|RNA binding	nuclear envelope|nucleus|transcription export complex 2|nuclear pore
YFL023W	YFL023W	BUD27	hom	Verified	0.46178247183922	0.322118660941804	no	1479	0.321315230242937	1088	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION		RIBOSOME	Unconventional prefoldin protein involved in translation initiation; mutants have inappropriate expression of nutrient sensitive genes due to translational derepression of Gcn4p transcription factor; diploid mutants show random budding; ortholog of human URI/RMP	formation of translation preinitiation complex	molecular_function	cytosolic ribosome|cytoplasm
YCR026C	YCR026C	NPP1	hom	Verified	0.461623478563663	0.322175677319613	no	1480	0.349643678479831	1188	NA	FT	NUCLEOTIDE METABOLISM|RESPONSE TO NUTRIENT LEVELS			Nucleotide pyrophosphatase/phosphodiesterase; mediates extracellular nucleotide phosphate hydrolysis along with Npp2p and Pho5p; activity and expression enhanced during conditions of phosphate starvation; NPP1 has a paralog, NPP2, that arose from the whole genome duplication	cellular response to phosphate starvation|phosphate-containing compound metabolic process|nucleoside triphosphate metabolic process	nucleotide diphosphatase activity|nucleoside-triphosphate diphosphatase activity|nucleoside-triphosphatase activity|phosphodiesterase I activity	cellular_component
YNL140C_p	YNL140C	YNL140C	hom	Uncharacterized	0.461143586218399	0.322347796281274	no	1481	0.367785830866264	1229	NA					Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps THO2/YNL139C	biological_process	molecular_function	cellular_component
YMR292W	YMR292W	GOT1	hom	Verified	0.460184494699949	0.322691899703768	no	1482	0.305089774886895	1042	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Homodimeric protein that is packaged into COPII vesicles and cycles between the ER and Golgi; involved in secretory transport but not directly required for aspects of transport assayed in vitro; may influence membrane composition	ER to Golgi vesicle-mediated transport|Golgi to endosome transport	molecular_function	integral to membrane|endoplasmic reticulum|Golgi apparatus|ER to Golgi transport vesicle|Golgi membrane
YOR364W_d	YOR364W	YOR364W	hom	Dubious	0.4578616450271	0.323525922068466	no	1483	0.305623627087408	988	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR365C	Unknown	Unknown	Unknown
YLR455W	YLR455W	YLR455W	hom	Verified	0.457445787017378	0.323675330226784	no	1484	0.335542337879845	1107	NA	FT		NUCLEUS		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO); protein abundance increases in response to DNA replication stress	biological_process	molecular_function	nucleus
YBL007C	YBL007C	SLA1	hom	Verified	0.457260619783372	0.323741865675809	no	1485	0.363952908513888	1202	NA	FF|FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION	NUCLEUS|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON		Cytoskeletal protein binding protein required for assembly of the cortical actin cytoskeleton; interacts with proteins regulating actin dynamics and proteins required for endocytosis; found in the nucleus and cell cortex; has 3 SH3 domains	fungal-type cell wall organization|endocytosis|actin cortical patch assembly	ubiquitin binding|protein binding, bridging	cell cortex|nucleus|mating projection tip|actin cortical patch
YNL043C_d	YNL043C	YNL043C	hom	Dubious	0.45719895611037	0.323764024303142	no	1486	0.328194971350896	1102	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YIP3/YNL044W	Unknown	Unknown	Unknown
YIR009W	YIR009W	MSL1	hom	Verified	0.457110282629457	0.32379588990649	no	1487	0.343247903947267	1153	NA	FT	RNA PROCESSING	NUCLEUS		U2B component of U2 snRNP, involved in splicing, binds the U2 snRNA stem-loop IV in vitro but requires association of Lea1p for in vivo binding; does not contain the conserved C-terminal RNA binding domain found in other family members	mRNA splicing, via spliceosome	U2 snRNA binding	U2 snRNP|U2-type prespliceosome
YER030W	YER030W	CHZ1	hom	Verified	0.456988090161158	0.323839802972084	no	1488	0.29518105491358	1000	NA	FT	CHROMATIN ORGANIZATION	NUCLEUS		Histone chaperone for Htz1p/H2A-H2B dimer; required for the stabilization of the Chz1p-Htz1-H2B complex; has overlapping function with Nap1p; null mutant displays weak sensitivity to MMS and benomyl; contains a highly conserved CHZ motif; protein abundance increases in response to DNA replication stress	chromatin remodeling	histone binding	chromatin assembly complex|nucleus
YDR217C	YDR217C	RAD9	hom	Verified	0.456240366555965	0.32410857043873	no	1489	0.315955687206074	1083	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		DNA damage-dependent checkpoint protein; required for cell-cycle arrest in G1/S, intra-S, and G2/M; transmits checkpoint signal by activating Rad53p and Chk1p; hyperphosphorylated by Mec1p and Tel1p; multiple cyclin dependent kinase consensus sites and the C-terminal BRCT domain contribute to DNA damage checkpoint activation; potential Cdc28p substrate	DNA repair|mitotic cell cycle G1/S transition DNA damage checkpoint|regulation of cell cycle|intra-S DNA damage checkpoint|nucleotide-excision repair|DNA damage checkpoint|positive regulation of transcription from RNA polymerase II promoter	double-stranded DNA binding|histone binding	chromatin|nucleus
YLR354C	YLR354C	TAL1	hom	Verified	0.456234565087479	0.324110656121411	no	1490	0.352041885132742	1188	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		Transaldolase, enzyme in the non-oxidative pentose phosphate pathway; converts sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate to erythrose 4-phosphate and fructose 6-phosphate	pentose-phosphate shunt	sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity	nucleus|cytoplasm
YFL025C	YFL025C	BST1	hom	Verified	0.453818436951494	0.324979756222425	no	1491	0.394468072351551	1299	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|PROTEOLYSIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		GPI inositol deacylase of the ER that negatively regulates COPII vesicle formation, prevents production of vesicles with defective subunits, required for proper discrimination between resident ER proteins and Golgi-bound cargo molecules	protein retention in ER lumen|vesicle organization|ER-associated protein catabolic process|ER to Golgi vesicle-mediated transport|GPI anchor metabolic process	phosphatidylinositol deacylase activity	integral to membrane|endoplasmic reticulum
YLR287C-A	YLR287C-A	RPS30A	hom	Verified	0.453283721665642	0.325172226472328	no	1492	0.315921751681069	1084	NA	FT	TRANSLATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S30, no bacterial homolog; RPS30A has a paralog, RPS30B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic small ribosomal subunit|cytoplasmic stress granule
YDL162C_d	YDL162C	YDL162C	hom	Dubious	0.452863158401704	0.325323640593507	no	1493	0.328588939499688	1090	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps ENT1/YDL161W, a verified gene involved in endocytosis and actin cortical patch assembly	Unknown	Unknown	Unknown
YNL316C	YNL316C	PHA2	hom	Verified	0.452398021566365	0.325491135989785	no	1494	0.304969050705247	1035	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Prephenate dehydratase, catalyzes the conversion of prephanate to phenylpyruvate, which is a step in the phenylalanine biosynthesis pathway	L-phenylalanine biosynthetic process	prephenate dehydratase activity	cytoplasm
YPL246C	YPL246C	RBD2	hom	Verified	0.452377030401255	0.32549869572277	no	1495	0.312080976409976	1062	NA	FT	PROTEOLYSIS	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Possible rhomboid protease, has similarity to eukaryotic rhomboid proteases including Pcp1p	biological_process	molecular_function	COPI-coated vesicle|integral to membrane|Golgi apparatus
YDL022W	YDL022W	GPD1	hom	Verified	0.451687057720735	0.325747221599032	no	1496	0.319648311430454	1092	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM	NUCLEUS		NAD-dependent glycerol-3-phosphate dehydrogenase; key enzyme of glycerol synthesis, essential for growth under osmotic stress; expression regulated by high-osmolarity glycerol response pathway; homolog of Gpd2p; protein abundance increases in response to DNA replication stress; constitutively inactivated via phosphorylation by the protein kinases YPK1 and YPK2, dephosphorylation increases catalytic activity	NADH oxidation|intracellular accumulation of glycerol	glycerol-3-phosphate dehydrogenase [NAD+] activity	cytosol|peroxisome|nucleus
YHL027W	YHL027W	RIM101	hom	Verified	0.451121635113512	0.325950942707501	no	1497	0.351560792639258	1203	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|ION HOMEOSTASIS|CELL WALL ORG/BIOGENESIS|CELL DIVISION|ION HOMEOSTASIS	NUCLEUS		Cys2His2 zinc-finger transcriptional repressor; involved in alkaline responsive gene repression as part of adaptation to a alkaline conditions; involved in cell wall assembly; required for alkaline pH-stimulated haploid invasive growth and sporulation; activated by alkaline-dependent proteolytic processing which results in removal of the C-terminal tail; similar to A. nidulans PacC	meiosis|negative regulation of transcription from RNA polymerase II promoter|fungal-type cell wall biogenesis|cellular response to anoxia|response to pH|ascospore formation|barrier septum assembly|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|sequence-specific DNA binding	nucleus
YPR130C_d	YPR130C	YPR130C	hom	Dubious	0.450177013684552	0.326291404623936	no	1498	0.329164288507534	1103	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDR514C	YDR514C	YDR514C	hom	Verified	0.449832841321867	0.32641548776479	no	1499	0.319352589286441	1065	NA	FT		NUCLEUS|MITOCHONDRION		Protein of unknown function that localizes to mitochondria; overexpression affects endocytic protein trafficking; YDR514C has a paralog, GFD2, that arose from the whole genome duplication	biological_process	molecular_function	mitochondrion|nucleus
YHR161C	YHR161C	YAP1801	hom	Verified	0.448325256702468	0.326959237695166	no	1500	0.328125019467066	1108	NA	FT	VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON		Protein of the AP180 family, involved in clathrin cage assembly; binds Pan1p and clathrin; YAP1801 has a paralog, YAP1802, that arose from the whole genome duplication	endocytosis	clathrin binding	actin cortical patch
YML082W_p	YML082W	YML082W	hom	Uncharacterized	0.447768139335682	0.327160269768619	no	1501	0.353121281260708	1202	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Putative protein predicted to have carbon-sulfur lyase activity; transcriptionally regulated by Upc2p via an upstream sterol response element; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and the cytoplasm; YML082W is not an essential gene	sulfur compound metabolic process	carbon-sulfur lyase activity	nucleus|cytoplasm
YOR187W	YOR187W	TUF1	hom	Verified	0.44729175055861	0.327332211253172	no	1502	0.401632744749856	1305	NA	FT	TRANSLATION|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial translation elongation factor Tu; comprises both GTPase and guanine nucleotide exchange factor activities, while these activities are found in separate proteins in S. pombe and humans	mitochondrial translational elongation|mitochondrial translation	GTPase activity|translation elongation factor activity	mitochondrion|mitochondrial matrix
YDL041W_d	YDL041W	YDL041W	hom	Dubious	0.447044617160172	0.327421422760566	no	1503	0.354086916265796	1210	NA	FF				Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene SIR2/YDL042C	Unknown	Unknown	Unknown
YBR001C	YBR001C	NTH2	hom	Verified	0.446934291437137	0.327461251899924	no	1504	0.389880577640867	1305	NA	FF|FT	CARBOHYDRATE METABOLISM	MITOCHONDRION		Putative neutral trehalase, required for thermotolerance; may mediate resistance to other cellular stresses; NTH2 has a paralog, NTH1, that arose from the whole genome duplication	trehalose catabolic process	alpha,alpha-trehalase activity	mitochondrion|cytoplasm
YNL276C_d	YNL276C	YNL276C	hom	Dubious	0.445284317974551	0.328057149656838	no	1505	0.333920568523719	1148	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene MET2/YNL277W	Unknown	Unknown	Unknown
YKR045C_p	YKR045C	YKR045C	hom	Uncharacterized	0.445107107691924	0.328121176275869	no	1506	0.329065446733344	1091	NA					Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm	biological_process	molecular_function	cytoplasm
YOR306C	YOR306C	MCH5	hom	Verified	0.444503643397259	0.328339247651114	no	1507	0.317728071914489	1066	NA	FT		PLASMA MEMBRANE		Plasma membrane riboflavin transporter; facilitates the uptake of vitamin B2; required for FAD-dependent processes; sequence similarity to mammalian monocarboxylate permeases, however mutants are not deficient in monocarboxylate transport	riboflavin transport	monocarboxylic acid transmembrane transporter activity|riboflavin transporter activity	integral to membrane|plasma membrane
YDR503C	YDR503C	LPP1	hom	Verified	0.443585276234561	0.32867122640331	no	1508	0.315565415322429	1058	NA	FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Lipid phosphate phosphatase, catalyzes Mg(2+)-independent dephosphorylation of phosphatidic acid (PA), lysophosphatidic acid, and diacylglycerol pyrophosphate; involved in control of the cellular levels of phosphatidylinositol and PA	phospholipid metabolic process	phosphatidate phosphatase activity	integral to membrane|membrane
YKL053C-A	YKL053C-A	MDM35	hom	Verified	0.44323238786107	0.32879882731949	no	1509	0.341562706036243	1178	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION	NUCLEUS|MITOCHONDRION		Mitochondrial intermembrane space protein; mutation affects mitochondrial distribution and morphology; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress	mitochondrion organization|mitochondrial respiratory chain complex assembly	molecular_function	nucleus|cytoplasm|mitochondrial intermembrane space
YPL105C	YPL105C	SYH1	hom	Verified	0.4431450096947	0.328830425476422	no	1510	0.324341100266322	1110	NA	FT	PROTEIN LOCALIZATION	MITOCHONDRION		Protein of unknown function that influences nuclear pore distribution; co-purifies with ribosomes; contains a GYF domain, which bind proline-rich sequences; deletion extends chronological lifespan; SYH1 has a paralog, SMY2, that arose from the whole genome duplication	nuclear pore distribution	molecular_function	mitochondrion|ribosome|cytoplasmic mRNA processing body|extrinsic to membrane|cytoplasm
YDL048C	YDL048C	STP4	hom	Verified	0.442589798971907	0.329031232308183	no	1511	0.332730604466571	1121	NA	FT		NUCLEUS|MITOCHONDRION		Protein containing a Kruppel-type zinc-finger domain; has similarity to Stp1p, Stp2p, and Stp3p; predicted to be a transcription factor; relative distribution to the nucleus increases upon DNA replication stress	biological_process	sequence-specific DNA binding	mitochondrion|nucleus|cytoplasm
YCR043C_p	YCR043C	YCR043C	hom	Uncharacterized	0.442429127823374	0.329089352542701	no	1512	0.339489867480988	1131	NA	FT		GOLGI APPARATUS|SITE OF POLARIZED GROWTH		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi apparatus; YCR043C is not an essential gene	biological_process	molecular_function	Golgi apparatus|mating projection tip
YNL175C	YNL175C	NOP13	hom	Verified	0.44020809303939	0.329893199362595	no	1513	0.344605281431076	1137	NA	FT		NUCLEUS		Nucleolar protein found in preribosomal complexes; contains an RNA recognition motif (RRM); relative distribution to the nucleolus increases upon DNA replication stress	biological_process	RNA binding	nucleolus|preribosome
YLR237W	YLR237W	THI7	hom	Verified	0.440195563661011	0.329897736284551	no	1514	0.346617701334061	1153	NA	FT		PLASMA MEMBRANE		Plasma membrane transporter responsible for the uptake of thiamine, member of the major facilitator superfamily of transporters; mutation of human ortholog causes thiamine-responsive megaloblastic anemia	thiamine transport	thiamine transmembrane transporter activity	integral to membrane|plasma membrane
YLR084C	YLR084C	RAX2	hom	Verified	0.439759054312883	0.330055813123194	no	1515	0.362079690291318	1220	NA	FT	CELL CYCLE|CELL DIVISION	MITOCHONDRION|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		N-glycosylated protein involved in the maintenance of bud site selection during bipolar budding; localization requires Rax1p; RAX2 mRNA stability is regulated by Mpt5p	cellular bud site selection	molecular_function	mitochondrion|cellular bud scar|cellular bud neck|membrane
YBR058C-A	YBR058C-A	TSC3	hom	Verified	0.43945497290399	0.330165950642276	no	1516	0.436192027723747	1452	NA	FF|FT	KETONE METABOLISM|LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein that stimulates the activity of serine palmitoyltransferase (Lcb1p, Lcb2p) several-fold; involved in sphingolipid biosynthesis	3-keto-sphinganine metabolic process|sphingolipid biosynthetic process	enzyme activator activity	SPOTS complex
YKR090W	YKR090W	PXL1	hom	Verified	0.437280106482187	0.330954110381471	no	1517	0.334505924197981	1132	NA	FT	SIGNALING	SITE OF POLARIZED GROWTH		Protein that localizes to sites of polarized growth; required for selection and/or maintenance of polarized growth sites, may modulate signaling by the GTPases Cdc42p and Rho1p; contains LIM domains and has similarity to metazoan paxillin; relocalizes from bud neck to cytoplasm upon DNA replication stress	maintenance of cell polarity|regulation of Rho protein signal transduction	Rho GDP-dissociation inhibitor activity	incipient cellular bud site|cellular bud|mating projection tip|cellular bud neck|cytoplasm|cellular bud tip
YIL054W_p	YIL054W	YIL054W	hom	Uncharacterized	0.436593908138018	0.331202940695431	no	1518	0.335076963296253	1156	NA					Protein of unknown function; expressed at both mRNA and protein levels	biological_process	molecular_function	cellular_component
YER051W	YER051W	JHD1	hom	Verified	0.436449646830154	0.331255262444041	no	1519	0.325012101841078	1071	NA	FT	CHROMATIN ORGANIZATION|OXIDATION-REDUCTION PROCESS	NUCLEUS		JmjC domain family histone demethylase specific for H3-K36, similar to proteins found in human, mouse, drosophila, X. laevis, C. elegans, and S. pombe	histone demethylation	methylated histone residue binding|histone demethylase activity (H3-K36 specific)	cellular_component
YHR134W	YHR134W	WSS1	hom	Verified	0.436329288898495	0.331298917261835	no	1520	0.27504916099381	952	NA	FT	RESPONSE TO DNA DAMAGE	ENDOMEMBRANE SYSTEM|NUCLEUS		Sumoylated protein that localizes to a single spot on the nuclear periphery of mother cells but not daughters; interacts genetically with SMT3; UV-sensitive mutant phenotype and genetic interactions suggest a role in the DNA damage response	protein sumoylation|response to UV-B|response to UV-C|response to DNA damage stimulus	molecular_function	nuclear envelope
YMR241W	YMR241W	YHM2	hom	Verified	0.435694146284954	0.33152932670321	no	1521	0.337355735512834	1139	NA	FT	ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS	MITOCHONDRION		Carrier protein that exports citrate from and imports oxoglutarate into the mitochondrion, causing net export of NADPH reducing equivalents; also associates with mt nucleoids and has a role in replication and segregation of the mt genome	tricarboxylic acid transport|mitochondrial citrate transport|alpha-ketoglutarate transport|mitochondrial genome maintenance	tricarboxylate secondary active transmembrane transporter activity|DNA binding	mitochondrial nucleoid|mitochondrion|integral to membrane|mitochondrial inner membrane
YLR091W	YLR091W	GEP5	hom	Verified	0.435318770281377	0.331665531106702	no	1522	0.353260192088142	1185	NA	FT	MITOCHONDRION ORGANIZATION	MITOCHONDRION		Protein of unknown function, required for mitochondrial genome maintenance; detected in highly purified mitochondria in high-throughput studies; null mutant has decreased levels of cardiolipin and phosphatidylethanolamine	mitochondrial genome maintenance	molecular_function	mitochondrion
YNL041C	YNL041C	COG6	hom	Verified	0.434970929817794	0.331791764166474	no	1523	0.417099515166256	1372	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments	intra-Golgi vesicle-mediated transport|CVT pathway	molecular_function	Golgi transport complex
YLR193C	YLR193C	UPS1	hom	Verified	0.434215905493688	0.332065832013956	no	1524	0.300947750815012	1040	NA	FT	LIPID METABOLISM	MITOCHONDRION		Phosphatidic acid transfer protein; plays a role in phospholipid metabolism by transporting phosphatidic acid from the outer to the inner mitochondrial membrane; localizes to the mitochondrial intermembrane space; null mutant has altered cardiolipin and phosphatidic acid levels; ortholog of human PRELI	Unknown|cardiolipin metabolic process	molecular_function	mitochondrion|extrinsic to mitochondrial inner membrane|mitochondrial intermembrane space
YGR061C	YGR061C	ADE6	hom	Verified	0.433499593561598	0.332325930644535	no	1525	0.319307012641685	1066	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEOTIDE METABOLISM			Formylglycinamidine-ribonucleotide (FGAM)-synthetase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway	'de novo' IMP biosynthetic process|purine nucleotide biosynthetic process	phosphoribosylformylglycinamidine synthase activity	cytoplasm
YMR070W	YMR070W	MOT3	hom	Verified	0.432649105241207	0.332634854685746	no	1526	0.359658361879038	1215	NA	FT	TRANSCRIPTION FROM RNA POL II|LIPID METABOLISM	NUCLEUS		Transcriptional repressor and activator with two C2-H2 zinc fingers; involved in repression of a subset of hypoxic genes by Rox1p, repression of several DAN/TIR genes during aerobic growth, and repression of ergosterol biosynthetic genes in response to hyperosmotic stress; contributes to recruitment of the Tup1p-Cyc8p general repressor to promoters; involved in positive transcriptional regulation of CWP2 and other genes; can form the [MOT3+] prion	cellular hyperosmotic response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of ergosterol biosynthetic process|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II repressing transcription factor binding|RNA polymerase II activating transcription factor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding	nucleus
YLR131C	YLR131C	ACE2	hom	Verified	0.432306207513704	0.332759438068577	no	1527	0.466010224547097	1539	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CELL DIVISION	NUCLEUS		Transcription factor required for septum destruction after cytokinesis; phosphorylation by Cbk1p blocks nuclear exit during M/G1 transition, causing localization to daughter cell nuclei, and also increases Ace2p activity; phosphorylation by Cdc28p and Pho85p prevents nuclear import during cell cycle phases other than cytokinesis; part of RAM network that regulates cellular polarity and morphogenesis; ACE2 has a paralog, SWI5, that arose from the whole genome duplication	Unknown|regulation of transcription involved in G1 phase of mitotic cell cycle	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity|core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding	cytosol|nucleus
YKR049C	YKR049C	FMP46	hom	Verified	0.432287143085327	0.332766365197767	no	1528	0.314337488237937	1062	NA	FT	OXIDATION-REDUCTION PROCESS	MITOCHONDRION		Putative redox protein containing a thioredoxin fold; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	oxidoreductase activity	mitochondrion
YFR010W	YFR010W	UBP6	hom	Verified	0.43115628397198	0.333177369016024	no	1529	0.363673348198301	1205	NA	FT	PROTEOLYSIS			Ubiquitin-specific protease situated in the base subcomplex of the 26S proteasome, releases free ubiquitin from branched polyubiquitin chains; works in opposition to Hul5p polyubiquitin elongation activity; mutant has aneuploidy tolerance	protein deubiquitination	ubiquitin-specific protease activity	proteasome complex|proteasome regulatory particle
YLR154C	YLR154C	RNH203	hom	Verified	0.430623189054765	0.333371188642091	no	1530	0.316618768246395	1075	NA	FT		NUCLEUS		Ribonuclease H2 subunit, required for RNase H2 activity; related to human AGS3 that causes Aicardi-Goutieres syndrome	RNA catabolic process|DNA replication, removal of RNA primer	ribonuclease H activity	ribonuclease H2 complex|nucleus|cytoplasm
YGL200C	YGL200C	EMP24	hom	Verified	0.429605892725762	0.333741174913901	no	1531	0.343474142826813	1178	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Component of the p24 complex; binds to GPI anchor proteins and mediates their efficient transport from the ER to the Golgi; integral membrane protein that associates with endoplasmic reticulum-derived COPII-coated vesicles	protein retention in ER lumen|vesicle organization|ER to Golgi vesicle-mediated transport	molecular_function	integral to membrane|endoplasmic reticulum|ER to Golgi transport vesicle
YAL022C	YAL022C	FUN26	hom	Verified	0.429288993025932	0.333856463015843	no	1532	0.335799909680954	1121	NA					Vacuolar membrane transporter with broad nucleoside selectivity; may regulate balance of nicotinamide riboside (NmR) levels between cytosol and vacuole, contributing to salvage of NmR for use in cytosolic NAD+ synthesis	nucleoside transport|nicotinamide riboside transport|transmembrane transport	nicotinamide riboside transporter activity|nucleoside transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane|intracellular|membrane
YKL198C	YKL198C	PTK1	hom	Verified	0.428768036277085	0.334046021148674	no	1533	0.330412807288593	1113	NA	FT	PROTEIN PHOSPHORYLATION			Putative serine/threonine protein kinase that regulates spermine uptake; involved in polyamine transport; possible mitochondrial protein	polyamine transport	protein kinase activity	cellular_component
YAL042W	YAL042W	ERV46	hom	Verified	0.428715689261401	0.33406507075818	no	1534	0.345458900715744	1151	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Protein localized to COPII-coated vesicles, forms a complex with Erv41p; involved in the membrane fusion stage of transport	ER to Golgi vesicle-mediated transport	molecular_function	integral to endoplasmic reticulum membrane|integral to Golgi membrane|ER to Golgi transport vesicle
YLR441C	YLR441C	RPS1A	hom	Verified	0.428309536591796	0.334212888354134	no	1535	0.352994533680744	1184	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Ribosomal protein 10 (rp10) of the small (40S) subunit; homologous to mammalian ribosomal protein S3A, no bacterial homolog; RPS1A has a paralog, RPS1B, that arose from the whole genome duplication	cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome	cytosolic small ribosomal subunit|90S preribosome
YGL226W	YGL226W	MTC3	hom	Verified	0.427927935075482	0.334351794090716	no	1536	0.327614587584408	1109	NA	FT		MITOCHONDRION		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; mtc3 is synthetically sick with cdc13-1	biological_process	molecular_function	mitochondrion
YKL184W	YKL184W	SPE1	hom	Verified	0.426994337161455	0.334691726150101	no	1537	0.337207670403433	1154	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM			Ornithine decarboxylase, catalyzes the first step in polyamine biosynthesis; degraded in a proteasome-dependent manner in the presence of excess polyamines; deletion decreases lifespan, and increases necrotic cell death and ROS generation	pantothenate biosynthetic process|putrescine biosynthetic process	ornithine decarboxylase activity	cytoplasm
YPL270W	YPL270W	MDL2	hom	Verified	0.425650745279343	0.335181178819956	no	1538	0.338547479749313	1153	NA	FT	NUCLEOTIDE METABOLISM	MITOCHONDRION		Mitochondrial inner membrane half-type ATP-binding cassette (ABC) transporter, required for respiratory growth at high temperature; similar to human TAP1 and TAP2 implicated in bare lymphocyte syndrome and Wegener-like granulomatosis	oligopeptide transport|oligopeptide export from mitochondrion	oligopeptide-transporting ATPase activity	mitochondrion|integral to membrane|mitochondrial inner membrane
YIL161W_p	YIL161W	YIL161W	hom	Uncharacterized	0.425573537686206	0.3352093130343	no	1539	0.319819944268286	1055	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; mRNA is enriched in Scp160p-associated mRNPs; YIL161W is a non-essential gene	biological_process	molecular_function	cytoplasm
YHR191C	YHR191C	CTF8	hom	Verified	0.421993380425588	0.336514924576283	no	1540	0.390584640413096	1280	NA	FT	CELL CYCLE|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME		Subunit of a complex with Ctf18p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion	maintenance of DNA trinucleotide repeats|mitotic sister chromatid cohesion	molecular_function	Ctf18 RFC-like complex
YNR051C	YNR051C	BRE5	hom	Verified	0.421051749022239	0.336858647097178	no	1541	0.333948762932623	1145	NA	FT	VESICLE-MEDIATED TRANSPORT			Ubiquitin protease cofactor, forms deubiquitination complex with Ubp3p that coregulates anterograde and retrograde transport between the endoplasmic reticulum and Golgi compartments; null is sensitive to brefeldin A	protein deubiquitination|ribophagy|regulation of ER to Golgi vesicle-mediated transport|Unknown	molecular_function	cytoplasm
YIL057C	YIL057C	RGI2	hom	Verified	0.420748774854876	0.336969270370414	no	1542	0.35203447870259	1188	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY			Protein of unknown function involved in energy metabolism under respiratory conditions; expression induced under carbon limitation and repressed under high glucose	energy reserve metabolic process	molecular_function	cytoplasm
YBR206W_d	YBR206W	YBR206W	hom	Dubious	0.420657816910507	0.337002484091785	no	1543	0.341143107883218	1156	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene KTR3	Unknown	Unknown	Unknown
YMR244C-A	YMR244C-A	COA6	hom	Verified	0.419744805871264	0.337335944732266	no	1544	0.328976901491385	1092	NA	FT		NUCLEUS|MITOCHONDRION		Protein involved in cytochrome c oxidase assembly; also required for efficient formation of respiratory supercomplexes comprised of Complexes III and IV; localizes to the mitochondrial intermembrane space; has a human homolog; transcription is induced in response to the DNA-damaging agent MMS; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	nucleus|cytoplasm
YPR097W	YPR097W	YPR097W	hom	Verified	0.419611492330606	0.337384645772706	no	1545	0.354820448069637	1198	NA	FT		MITOCHONDRION		Protein that contains a Phox homology (PX) domain and binds phosphoinositides; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	phosphatidylinositol binding	mitochondrion
YLR165C	YLR165C	PUS5	hom	Verified	0.418065338977575	0.337949673041366	no	1546	0.344545188368826	1147	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	MITOCHONDRION		Pseudouridine synthase, catalyzes only the formation of pseudouridine (Psi)-2819 in mitochondrial 21S rRNA; not essential for viability	rRNA modification|pseudouridine synthesis	pseudouridylate synthase activity	mitochondrion
YML123C	YML123C	PHO84	hom	Verified	0.416861039532305	0.338390026167024	no	1547	0.364514219340157	1209	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		High-affinity inorganic phosphate (Pi) transporter and low-affinity manganese transporter; regulated by Pho4p and Spt7p; mutation confers resistance to arsenate; exit from the ER during maturation requires Pho86p; cells overexpressing Pho84p accumulate heavy metals but do not develop symptoms of metal toxicity	phosphate ion transport|manganese ion transport|polyphosphate metabolic process	manganese ion transmembrane transporter activity|inorganic phosphate transmembrane transporter activity	integral to membrane|integral to plasma membrane
YPR123C_d	YPR123C	YPR123C	hom	Dubious	0.416707164723959	0.338446306565421	no	1548	0.427714013638836	1399	NA	FF				Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially/completely overlaps the verified ORF CTR	Unknown	Unknown	Unknown
YLR126C	YLR126C	YLR126C	hom	Verified	0.41667844846303	0.338456810065731	no	1549	0.330412305672484	1128	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|ION HOMEOSTASIS|ION HOMEOSTASIS			Putative glutamine amidotransferase; has Aft1p-binding motif in the promoter; may be involved in copper and iron homeostasis; YLR126C is not an essential protein; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress	cellular copper ion homeostasis|cellular iron ion homeostasis	molecular_function	cytoplasm
YOL041C	YOL041C	NOP12	hom	Verified	0.416359102103559	0.338573625335753	no	1550	0.330135854994626	1089	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Nucleolar protein involved in pre-25S rRNA processing and biogenesis of large 60S ribosomal subunit; contains an RNA recognition motif (RRM); binds to Ebp2; similar to Nop13p and Nsr1p	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	RNA binding	nucleolus|preribosome
YGL250W	YGL250W	RMR1	hom	Verified	0.416215470098343	0.338626170255769	no	1551	0.331227850670456	1136	NA	FT	CELL CYCLE	NUCLEUS		Protein required for meiotic recombination and gene conversion; null mutant displays reduced PIS1 expression and growth defects on non-fermentable carbon sources and minimal media; GFP-fusion protein localizes to both cytoplasm and nucleus	meiotic gene conversion|reciprocal meiotic recombination	molecular_function	nucleus|cytoplasm
YAL015C	YAL015C	NTG1	hom	Verified	0.414949620499359	0.339089391959421	no	1552	0.323427576741678	1090	NA	FT	RESPONSE TO DNA DAMAGE|MITOCHONDRION ORGANIZATION|RESPONSE TO OXIDATIVE STRESS	NUCLEUS|MITOCHONDRION		DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; NTG1 has a paralog, NTG2, that arose from the whole genome duplication	DNA repair|cellular response to oxidative stress|base-excision repair|base-excision repair, AP site formation|positive regulation of mitochondrial DNA replication	oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity|oxidized purine nucleobase lesion DNA N-glycosylase activity|DNA-(apurinic or apyrimidinic site) lyase activity	mitochondrion|nucleus
YDR286C_p	YDR286C	YDR286C	hom	Uncharacterized	0.413732099288872	0.339535158123033	no	1553	0.32188690326429	1086	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY			Putative protein of unknown function; predicted to have thiol-disulfide oxidoreductase active site	biological_process	molecular_function	cellular_component
YOL147C	YOL147C	PEX11	hom	Verified	0.413076326041249	0.339775346855719	no	1554	0.326820627549155	1073	NA	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|PEROXISOME ORGANIZATION	ENDOPLASMIC RETICULUM		Peroxisomal membrane protein required for medium-chain fatty acid oxidation and peroxisome proliferation, possibly by inducing membrane curvature; localization regulated by phosphorylation; transcription regulated by Adr1p and Pip2p-Oaf1p	peroxisome fission|fatty acid oxidation	molecular_function	endoplasmic reticulum|peroxisomal membrane
YLR061W	YLR061W	RPL22A	hom	Verified	0.413012815704818	0.339798612114978	no	1555	0.331564535570589	1116	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L22A; required for the oxidative stress response in yeast; homologous to mammalian ribosomal protein L22, no bacterial homolog; RPL22A has a paralog, RPL22B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YML004C	YML004C	GLO1	hom	Verified	0.412926236196278	0.339830329111894	no	1556	0.342951490508194	1137	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Monomeric glyoxalase I, catalyzes the detoxification of methylglyoxal (a by-product of glycolysis) via condensation with glutathione to produce S-D-lactoylglutathione; expression regulated by methylglyoxal levels and osmotic stress	methylglyoxal catabolic process to D-lactate|glutathione metabolic process	lactoylglutathione lyase activity	nucleus|cytoplasm
YPR173C	YPR173C	VPS4	hom	Verified	0.411859461893451	0.340221217552214	no	1557	0.363253090899088	1206	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|LIPID METABOLISM|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT	ENDOPLASMIC RETICULUM		AAA-ATPase involved in multivesicular body (MVB) protein sorting, ATP-bound Vps4p localizes to endosomes and catalyzes ESCRT-III disassembly and membrane release; ATPase activity is activated by Vta1p; regulates cellular sterol metabolism	late endosome to vacuole transport via multivesicular body sorting pathway|protein retention in Golgi apparatus|intralumenal vesicle formation|protein homooligomerization|sterol metabolic process|late endosome to vacuole transport	ATPase activity|protein homodimerization activity|ATP binding	endosome|endoplasmic reticulum|membrane|cytoplasm
YER129W	YER129W	SAK1	hom	Verified	0.411612119293463	0.340311873604836	no	1558	0.351179494544675	1189	NA	FT	CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION			Upstream serine/threonine kinase for the SNF1 complex; partially redundant with Elm1p and Tos3p; members of this family have functional orthology with LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome	protein phosphorylation|glucose metabolic process|DNA-dependent DNA replication	protein serine/threonine kinase activity|protein kinase activity	cytoplasm
YMR022W	YMR022W	UBC7	hom	Verified	0.411042728419895	0.340520601919675	no	1559	0.359297660922294	1218	NA	FT	CHROMATIN ORGANIZATION|CELL WALL ORG/BIOGENESIS|PROTEOLYSIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly	fungal-type cell wall organization|chromatin assembly or disassembly|ER-associated protein catabolic process	ubiquitin-protein ligase activity	endoplasmic reticulum membrane
YER156C_p	YER156C	YER156C	hom	Uncharacterized	0.410568353787277	0.340694536323112	no	1560	0.310994031411691	1048	NA	FT		NUCLEUS		Putative protein of unknown function; interacts with Hsp82p and copurifies with Ipl1p; expression is copper responsive and downregulated in strains deleted for MAC1, a copper-responsive transcription factor; similarity to mammalian MYG1	biological_process	molecular_function	nucleus|cytoplasm
YGR121W-A_p	YGR121W-A	YGR121W-A	hom	Uncharacterized	0.410234268047837	0.340817052675489	no	1561	0.337872991478314	1111	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YBR076W	YBR076W	ECM8	hom	Verified	0.410130280433741	0.340855190574568	no	1562	0.351154194543285	1154	NA	FT	CELL WALL ORG/BIOGENESIS			Non-essential protein of unknown function	fungal-type cell wall organization	molecular_function	cellular_component
YPL108W_p	YPL108W	YPL108W	hom	Uncharacterized	0.409704970316971	0.341011191793374	no	1563	0.348250095548306	1185	NA					Cytoplasmic protein of unknown function; non-essential gene that is induced in a GDH1 deleted strain with altered redox metabolism; GFP-fusion protein is induced in response to the DNA-damaging agent MMS	biological_process	molecular_function	cytoplasm
YNR036C	YNR036C	MRPS12	hom	Verified	0.409661630139291	0.341027090239225	no	1564	0.350795581696103	1178	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial protein; may interact with ribosomes based on co-purification experiments; similar to E. coli and human mitochondrial S12 ribosomal proteins	mitochondrial translation	structural constituent of ribosome	mitochondrion|ribosome|mitochondrial small ribosomal subunit
YJL154C	YJL154C	VPS35	hom	Verified	0.409417427702915	0.341116676116732	no	1565	0.368725511062522	1210	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM		Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p	protein retention in Golgi apparatus|retrograde transport, endosome to Golgi	protein transporter activity	endosome|retromer complex, inner shell|retromer complex
YBL052C	YBL052C	SAS3	hom	Verified	0.408916246880446	0.341300562790931	no	1566	0.331410924811256	1095	NA	FT	CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS	HISTONE ACETYLTRANSFERASE	Histone acetyltransferase catalytic subunit of NuA3 complex that acetylates histone H3, involved in transcriptional silencing; homolog of the mammalian MOZ proto-oncogene; mutant has aneuploidy tolerance; sas3gcn5 double mutation is lethal	histone acetylation|chromatin modification|chromatin silencing at telomere|chromatin silencing at silent mating-type cassette	histone acetyltransferase activity	NuA3 histone acetyltransferase complex
YBR120C	YBR120C	CBP6	hom	Verified	0.408902311269405	0.341305676400748	no	1567	0.337231120659217	1118	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial protein required for translation of the COB mRNA; forms a complex with Cbp3p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex	positive regulation of mitochondrial translation|mitochondrial respiratory chain complex III assembly	ribosome binding	mitochondrion|mitochondrial ribosome
YPL139C	YPL139C	UME1	hom	Verified	0.408530276949179	0.341442203492069	no	1568	0.343604482825337	1146	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS|CHROMOSOME		Negative regulator of meiosis, required for repression of a subset of meiotic genes during vegetative growth, binding of histone deacetylase Rpd3p required for activity, contains a NEE box and a WD repeat motif; homologous with Wtm1p, Wtm2p	positive regulation of transcription from RNA polymerase II promoter in response to heat stress|negative regulation of transcription from RNA polymerase I promoter|negative regulation of chromatin silencing at telomere|positive regulation of transcription from RNA polymerase II promoter|regulation of meiosis	transcription corepressor activity	Rpd3S complex|Rpd3L-Expanded complex|nucleus|Rpd3L complex
YJR088C	YJR088C	EMC2	hom	Verified	0.40796313013634	0.341650371809219	no	1569	0.32446163114561	1081	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm Y57G7A.10/EMC-2, fly CG17556, human TTC35	protein folding in endoplasmic reticulum	molecular_function	ER membrane protein complex|endoplasmic reticulum
YBR249C	YBR249C	ARO4	hom	Verified	0.407451234875951	0.341838301690043	no	1570	0.339081567540349	1130	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase; catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by tyrosine or high concentrations of phenylalanine or tryptophan; relative distribution to the nucleus increases upon DNA replication stress	aromatic amino acid family biosynthetic process	3-deoxy-7-phosphoheptulonate synthase activity	nucleus|cytoplasm
YOL150C_d	YOL150C	YOL150C	hom	Dubious	0.407307343677968	0.341891134899915	no	1571	0.334204015120598	1120	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YGR257C	YGR257C	MTM1	hom	Verified	0.407235378365224	0.341917559904925	no	1572	0.363206227225962	1228	NA	FF|FT	ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Mitochondrial protein of the mitochondrial carrier family, involved in activating mitochondrial Sod2p probably by facilitating insertion of an essential manganese cofactor	manganese ion transport|transport	transporter activity|metallochaperone activity	mitochondrion|integral to membrane|mitochondrial inner membrane
YPR116W	YPR116W	RRG8	hom	Verified	0.406487304464174	0.342192291648332	no	1573	0.334601005598486	1126	NA	FT	MITOCHONDRION ORGANIZATION	MITOCHONDRION		Putative protein of unknown function, required for mitochondrial genome maintenance; null mutation results in a decrease in plasma membrane electron transport	mitochondrial genome maintenance	molecular_function	mitochondrion
YOR025W	YOR025W	HST3	hom	Verified	0.405554396630123	0.342535021105879	no	1574	0.33519776773034	1112	NA	FT	KETONE METABOLISM|LIPID METABOLISM|CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS		Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst4p in telomeric silencing, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism	short-chain fatty acid metabolic process|histone deacetylation|chromatin silencing at telomere	histone deacetylase activity|DNA binding	nucleus
YDL034W_d	YDL034W	YDL034W	hom	Dubious	0.405360105672262	0.342606415581387	no	1575	0.336950797660457	1123	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps with verified gene GPR1/YDL035C; YDL034W is not an essential gene	Unknown	Unknown	Unknown
YIL066C	YIL066C	RNR3	hom	Verified	0.40526909477155	0.342639860530978	no	1576	0.342546760660623	1161	NA	FT	OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM	MITOCHONDRION		Minor isoform of the large subunit of ribonucleotide-diphosphate reductase; the RNR complex catalyzes rate-limiting step in dNTP synthesis, regulated by DNA replication and DNA damage checkpoint pathways via localization of small subunits	deoxyribonucleotide biosynthetic process	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	mitochondrion|ribonucleoside-diphosphate reductase complex|cytoplasm
YPR021C	YPR021C	AGC1	hom	Verified	0.404709632586638	0.342845480406909	no	1577	0.350840927728473	1211	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Mitochondrial amino acid transporter, acts both as a glutamate uniporter and as an aspartate-glutamate exchanger; involved in nitrogen metabolism and nitrogen compound biosynthesis	L-glutamate transport|aspartate transport|cellular nitrogen compound biosynthetic process	antiporter activity|L-aspartate transmembrane transporter activity|L-glutamate transmembrane transporter activity|uniporter activity	mitochondrion|integral to membrane|mitochondrial inner membrane
YDR448W	YDR448W	ADA2	hom	Verified	0.401691211099154	0.343955646755042	no	1578	0.397304415228154	1316	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS	HISTONE ACETYLTRANSFERASE	Transcription coactivator, component of the ADA and SAGA transcriptional adaptor/HAT (histone acetyltransferase) complexes	chromatin silencing at rDNA|chromatin modification|regulation of transcription from RNA polymerase II promoter|positive regulation of histone acetylation|chromatin silencing at telomere	chromatin binding|transcription coactivator activity|histone acetyltransferase activity|phosphatidylserine binding	SLIK (SAGA-like) complex|Ada2/Gcn5/Ada3 transcription activator complex|SAGA complex
YPL224C	YPL224C	MMT2	hom	Verified	0.401000153964515	0.344210005277113	no	1579	0.331057328204031	1084	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Putative metal transporter involved in mitochondrial iron accumulation; closely related to Mmt1p	cellular iron ion homeostasis	molecular_function	mitochondrion|integral to membrane
YDR406W	YDR406W	PDR15	hom	Verified	0.400797034837084	0.344284781074286	no	1580	0.346441226613753	1136	NA	FT	NUCLEOTIDE METABOLISM			Plasma membrane ATP binding cassette (ABC) transporter, multidrug transporter and general stress response factor implicated in cellular detoxification; regulated by Pdr1p, Pdr3p and Pdr8p; promoter contains a PDR responsive element	transport|response to drug	ATPase activity, coupled to transmembrane movement of substances	integral to membrane
YPL262W	YPL262W	FUM1	hom	Verified	0.39965707537785	0.344704555947824	no	1581	0.332040533876284	1125	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Fumarase, converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial distribution determined by the N-terminal targeting sequence, protein conformation, and status of glyoxylate shunt; phosphorylated in mitochondria	fumarate metabolic process|tricarboxylic acid cycle	fumarate hydratase activity	cytosol|mitochondrion|mitochondrial matrix
YOL001W	YOL001W	PHO80	hom	Verified	0.39922486481909	0.34486376176137	no	1582	0.366020937688016	1244	NA	FF|FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|CELL CYCLE|SIGNALING|ION HOMEOSTASIS|PROTEIN PHOSPHORYLATION|ION HOMEOSTASIS|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Cyclin, interacts with cyclin-dependent kinase Pho85p; regulates the response to nutrient levels and environmental conditions, including the response to phosphate limitation and stress-dependent calcium signaling	negative regulation of phosphate metabolic process|regulation of cyclin-dependent protein kinase activity|negative regulation of calcium-mediated signaling|negative regulation of transcription from RNA polymerase II promoter|cellular metal ion homeostasis|regulation of protein localization|negative regulation of macroautophagy	cyclin-dependent protein kinase regulator activity	cyclin-dependent protein kinase holoenzyme complex|nucleus
YJL198W	YJL198W	PHO90	hom	Verified	0.399070687958162	0.344920559833473	no	1583	0.344639663394171	1146	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Low-affinity phosphate transporter; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth; PHO90 has a paralog, PHO87, that arose from the whole genome duplication	phosphate ion transport	phosphate ion transmembrane transporter activity	integral to membrane|membrane
YLR068W	YLR068W	FYV7	hom	Verified	0.398070060380629	0.345289271489943	no	1584	0.353216064284805	1186	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Essential protein required for maturation of 18S rRNA; required for survival upon exposure to K1 killer toxin	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	molecular_function	nucleolus|nucleus
YOR243C	YOR243C	PUS7	hom	Verified	0.397762137350666	0.345402764664792	no	1585	0.3634075245818	1217	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Pseudouridine synthase, catalyzes pseudouridylation at positions 35 and 56 in U2 snRNA, position 50 in 5S rRNA, position 13 in cytoplasmic tRNAs, and position 35 in pre-tRNA(Tyr); conserved in archaea, vertebrates, and some bacteria	snRNA pseudouridine synthesis|tRNA pseudouridine synthesis|enzyme-directed rRNA pseudouridine synthesis	pseudouridine synthase activity	nucleus
YJL146W	YJL146W	IDS2	hom	Verified	0.396765687397664	0.345770127877677	no	1586	0.332808860616407	1107	NA	FT	CELL CYCLE	NUCLEUS		Protein involved in modulation of Ime2p activity during meiosis, appears to act indirectly to promote Ime2p-mediated late meiotic functions; found in growing cells and degraded during sporulation	meiosis	molecular_function	nucleus|cytoplasm
YKL037W	YKL037W	AIM26	hom	Verified	0.396738943032554	0.345779989779849	no	1587	0.385585587470884	1291	NA	FF|FT		MITOCHONDRION		Putative protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss; null mutation confers sensitivity to tunicamycin and DTT	mitochondrion degradation	molecular_function	mitochondrion|integral to membrane
YJR073C	YJR073C	OPI3	hom	Verified	0.396614574169574	0.345825851789239	no	1588	0.369668992744659	1250	NA	FF|FT	LIPID METABOLISM	MITOCHONDRION		Phospholipid methyltransferase (methylene-fatty-acyl-phospholipid synthase), catalyzes the last two steps in phosphatidylcholine biosynthesis	phosphatidylcholine biosynthetic process	phosphatidyl-N-dimethylethanolamine N-methyltransferase activity|phosphatidyl-N-methylethanolamine N-methyltransferase activity	mitochondrion|integral to membrane
YMR151W_d	YMR151W	YIM2	hom	Dubious	0.395692508444664	0.346165941394901	no	1589	0.338646302667329	1127	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1	Unknown	Unknown	Unknown
YIR007W_p	YIR007W	YIR007W	hom	Uncharacterized	0.394682302372815	0.346538682655929	no	1590	0.33759026245047	1089	NA	FT	CARBOHYDRATE METABOLISM			Putative glycosidase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YIR007W is a non-essential gene	biological_process	molecular_function	cytoplasm
YCR095W-A_p	YCR095W-A	YCR095W-A	hom	Uncharacterized	0.39327415721392	0.347058501618176	no	1591	0.345190363556052	1133	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YDR451C	YDR451C	YHP1	hom	Verified	0.390590887225859	0.348049831281674	no	1592	0.398430977772078	1331	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE	NUCLEUS|CHROMOSOME		Homeobox transcriptional repressor; binds Mcm1p and early cell cycle box (ECB) elements of cell cycle regulated genes, thereby restricting ECB-mediated transcription to the M/G1 interval; YHP1 has a paralog, YOX1, that arose from the whole genome duplication	negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription involved in G1 phase of mitotic cell cycle	RNA polymerase II regulatory region sequence-specific DNA binding|RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription	nuclear chromatin|nucleus
YFR044C	YFR044C	DUG1	hom	Verified	0.387684952827169	0.349124596244325	no	1593	0.352118704010504	1187	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|PROTEOLYSIS	MITOCHONDRION		Cys-Gly metallo-di-peptidase; forms a complex with Dug2p and Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p)	glutathione catabolic process	metallodipeptidase activity|omega peptidase activity	mitochondrion|ribosome|cytoplasm
YGL045W	YGL045W	RIM8	hom	Verified	0.387452065667805	0.349210782509812	no	1594	0.371100188098787	1223	NA	FF|FT	VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Protein involved in proteolytic activation of Rim101p in response to alkaline pH; interacts with ESCRT-1 subunits Stp22p and Vps28p; essential for anaerobic growth; member of the arrestin-related trafficking adaptor family	meiosis|protein processing|invasive growth in response to glucose limitation|ubiquitin-dependent endocytosis	molecular_function	internal side of plasma membrane
YDR477W	YDR477W	SNF1	hom	Verified	0.387241238416703	0.349288811609792	no	1595	0.347817368876347	1174	NA	FT	KETONE METABOLISM|SIGNALING|TRANSLATION|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS	ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION		AMP-activated serine/threonine protein kinase; found in a complex containing Snf4p and members of the Sip1p/Sip2p/Gal83p family; required for transcription of glucose-repressed genes, thermotolerance, sporulation, and peroxisome biogenesis; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p; regulates filamentous growth in response to starvation	negative regulation of translation|protein phosphorylation|replicative cell aging|signal transduction|biofilm formation|positive regulation of gluconeogenesis|pseudohyphal growth|cell adhesion|regulation of carbohydrate metabolic process|invasive growth in response to glucose limitation|cellular response to nitrogen starvation	AMP-activated protein kinase activity|protein kinase activity	mitochondrion|AMP-activated protein kinase complex|nucleus|nuclear envelope lumen|fungal-type vacuole|cytoplasm
YBR010W	YBR010W	HHT1	hom	Verified	0.387118365024249	0.349334291118318	no	1596	0.361251654747786	1225	NA	FT	CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Histone H3, core histone protein required for chromatin assembly, part of heterochromatin-mediated telomeric and HM silencing; one of two identical histone H3 proteins (see HHT2); regulated by acetylation, methylation, and phosphorylation	chromatin assembly or disassembly|global genome nucleotide-excision repair|rRNA transcription|sexual sporulation resulting in formation of a cellular spore|mitotic cell cycle spindle assembly checkpoint	DNA binding	replication fork protection complex|nucleus|nuclear nucleosome
YOR352W	YOR352W	TFB6	hom	Verified	0.387051162889079	0.349359165767501	no	1597	0.34764988621804	1162	NA	FT		NUCLEUS		Subunit of TFIIH complex; facilities dissociation of the Ssl2p helices from TFIIH; expression levels regulated by Arg5,6p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus	biological_process	molecular_function	nucleus|holo TFIIH complex|cytoplasm
YLR320W	YLR320W	MMS22	hom	Verified	0.385713044183641	0.349854600583763	no	1598	0.351850324271103	1194	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION	NUCLEUS	UBIQUITIN LIGASE COMPLEX	Subunit of an E3 ubiquitin ligase complex involved in replication repair; stabilizes protein components of the replication fork, such as the fork-pausing complex and leading strand polymerase, preventing fork collapse and promoting efficient recovery during replication stress; required for accurate meiotic chromosome segregation	replication fork processing|double-strand break repair|recombinational repair|meiotic sister chromatid segregation|response to DNA damage stimulus	molecular_function	Cul8-RING ubiquitin ligase complex|nucleus
YDL241W_p	YDL241W	YDL241W	hom	Uncharacterized	0.385442504973351	0.349954798099642	no	1599	0.339537211216084	1119	NA					Putative protein of unknown function; YDL241W is not an essential gene	biological_process	molecular_function	cellular_component
YLL007C_p	YLL007C	YLL007C	hom	Uncharacterized	0.38427602086948	0.35038693937304	no	1600	0.354644292082242	1217	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL007C is not an essential gene	biological_process	molecular_function	cytoplasm
YBL056W	YBL056W	PTC3	hom	Verified	0.383199195615165	0.350786037197664	no	1601	0.340919866214703	1149	NA	FT	CELL CYCLE|SIGNALING|PROTEIN PHOSPHORYLATION	NUCLEUS		Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p (see also Ptc2p) to limit maximal kinase activity induced by osmotic stress; dephosphorylates T169 phosphorylated Cdc28p (see also Ptc2p); role in DNA damage checkpoint inactivation; PTC3 has a paralog, PTC2, that arose from the whole genome duplication	inactivation of MAPK activity involved in osmosensory signaling pathway|regulation of cyclin-dependent protein kinase activity|protein dephosphorylation	protein serine/threonine phosphatase activity	nucleus|cytoplasm
YCR107W	YCR107W	AAD3	hom	Verified	0.382821735221543	0.350925972277422	no	1602	0.362485240801296	1201	NA	FT	OXIDATION-REDUCTION PROCESS			Putative aryl-alcohol dehydrogenase; similar to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role	cellular aldehyde metabolic process	aryl-alcohol dehydrogenase (NAD+) activity	cellular_component
YGR078C	YGR078C	PAC10	hom	Verified	0.38263280624691	0.350996021104774	no	1603	0.376386932835891	1233	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS			Part of the heteromeric co-chaperone GimC/prefoldin complex, which promotes efficient protein folding	tubulin complex assembly	tubulin binding	prefoldin complex|polysome|cytoplasm
YNL051W	YNL051W	COG5	hom	Verified	0.382354846705831	0.351099088826825	no	1604	0.395749969897562	1309	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments	intra-Golgi vesicle-mediated transport|CVT pathway	molecular_function	Golgi transport complex
YLR426W_p	YLR426W	TDA5	hom	Uncharacterized	0.382279578452036	0.351127000268221	no	1605	0.395081185384205	1287	NA	FT	OXIDATION-REDUCTION PROCESS	MITOCHONDRION		Putative protein of unknown function; detected in highly purified mitochondria in high-throughput studies; proposed to be involved in resistance to mechlorethamine and streptozotocin; null mutant sensitive to expression of top1-T722A allele	response to drug	molecular_function	mitochondrion|integral to membrane
YEL041W	YEL041W	YEF1	hom	Verified	0.381489226893983	0.351420131808947	no	1606	0.371015881519908	1202	NA	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM			ATP-NADH kinase; phosphorylates both NAD and NADH; homooctameric structure consisting of 60-kDa subunits; similar to Pos5p; overexpression complements certain pos5 phenotypes; YEF1 has a paralog, UTR1, that arose from the whole genome duplication	NADP biosynthetic process	NAD+ kinase activity|NADH kinase activity	cellular_component
YKL174C	YKL174C	TPO5	hom	Verified	0.380894211755228	0.351640873839965	no	1607	0.338792838807246	1112	NA	FT		ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Protein involved in excretion of putrescine and spermidine; putative polyamine transporter in the Golgi or post-Golgi vesicles	polyamine transport	polyamine transmembrane transporter activity	integral to membrane|Golgi apparatus
YDR277C	YDR277C	MTH1	hom	Verified	0.379425262707917	0.352186046835479	no	1608	0.350735952866856	1151	NA	FT	SIGNALING			Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation	glucose transport|signal transduction	molecular_function	cellular_component
YDR271C_d	YDR271C	YDR271C	hom	Dubious	0.379210655600531	0.352265719723853	no	1609	0.3714843875098	1225	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CCC2/YDR270W	Unknown	Unknown	Unknown
YLR334C_d	YLR334C	YLR334C	hom	Dubious	0.379074571190114	0.352316244420716	no	1610	0.329119695590644	1109	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps a stand-alone long terminal repeat sequence whose presence indicates a retrotransposition event occurred here	Unknown	Unknown	Unknown
YFR006W_p	YFR006W	YFR006W	hom	Uncharacterized	0.378958983511112	0.352359161247214	no	1611	0.347913269781006	1215	NA					Putative X-Pro aminopeptidase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YFR006W is not an essential gene	biological_process	molecular_function	cytoplasm
YIL027C	YIL027C	EMC5	hom	Verified	0.378847990015651	0.352400374057626	no	1612	0.377200723851841	1282	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response, and also shows K1 killer toxin resistance; homologous to worm B0334.15/EMC-5, fly CG15168, human MMGT	protein folding in endoplasmic reticulum	molecular_function	ER membrane protein complex|endoplasmic reticulum
YBR197C	YBR197C	YBR197C	hom	Verified	0.37779756358324	0.352790491899638	no	1613	0.355494549989231	1194	NA	FT		NUCLEUS		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YBR197C is not an essential gene; relative distribution to the nucleus increases upon DNA replication stress; YBR197C has a paralog, YPL077C, that arose from the whole genome duplication	biological_process	molecular_function	nucleus|cytoplasm
YPL039W_p	YPL039W	YPL039W	hom	Uncharacterized	0.377639869656973	0.352849071219459	no	1614	0.361987963404739	1220	NA					Putative protein of unknown function; YPL039W is not an essential gene	biological_process	molecular_function	cellular_component
YOR285W	YOR285W	RDL1	hom	Verified	0.37543636111124	0.353667983505715	no	1615	0.33877545954637	1124	NA	FT		ENDOPLASMIC RETICULUM|MITOCHONDRION		Protein of unknown function containing a rhodanese-like domain; localized to the mitochondrial outer membrane; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	mitochondrial outer membrane|mitochondrion|endoplasmic reticulum
YLR192C	YLR192C	HCR1	hom	Verified	0.375131301609966	0.353781409356927	no	1616	0.389691810930739	1277	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION			Dual function protein involved in translation initiation as a substoichiometric component (eIF3j) of translation initiation factor 3 (eIF3) and required for processing of 20S pre-rRNA; binds to eIF3 subunits Rpg1p and Prt1p and 18S rRNA	cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	translation initiation factor activity	eukaryotic translation initiation factor 3 complex
YMR055C	YMR055C	BUB2	hom	Verified	0.37499161345765	0.353833351910673	no	1617	0.347887205856949	1187	NA	FT	CELL CYCLE|SIGNALING|CELL DIVISION|NUCLEOTIDE METABOLISM	CYTOSKELETON		Mitotic exit network regulator, forms GTPase-activating Bfa1p-Bub2p complex that binds Tem1p and spindle pole bodies, blocks cell cycle progression before anaphase in response to spindle and kinetochore damage	regulation of exit from mitosis|mitotic cell cycle spindle orientation checkpoint	GTPase activator activity	spindle pole body
YBL049W	YBL049W	MOH1	hom	Verified	0.374753621464394	0.353921854672307	no	1618	0.371039509396378	1243	NA					Protein of unknown function, has homology to kinase Snf7p; not required for growth on nonfermentable carbon sources; essential for survival in stationary phase	biological_process	molecular_function	cellular_component
YBR067C	YBR067C	TIP1	hom	Verified	0.37408099102007	0.354172030342758	no	1619	0.361035939157941	1197	NA	FT	CELL WALL ORG/BIOGENESIS			Major cell wall mannoprotein with possible lipase activity; transcription is induced by heat- and cold-shock; member of the Srp1p/Tip1p family of serine-alanine-rich proteins	fungal-type cell wall organization	structural constituent of cell wall|lipase activity	fungal-type cell wall
YML047C	YML047C	PRM6	hom	Verified	0.374024002629699	0.354193229287431	no	1620	0.348232715769887	1147	NA					Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; regulated by Ste12p during mating; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family	biological_process	molecular_function	integral to membrane
YDL155W	YDL155W	CLB3	hom	Verified	0.373858286898293	0.354254875964915	no	1621	0.355798103982402	1182	NA	FT	CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION	NUCLEUS		B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation; relative distribution to the nucleus increases upon DNA replication stress	G2/M transition of mitotic cell cycle|S phase of mitotic cell cycle|regulation of cyclin-dependent protein kinase activity|positive regulation of spindle pole body separation	cyclin-dependent protein kinase regulator activity	nucleus|cytoplasm
YOL159C	YOL159C	YOL159C	hom	Verified	0.373388931222351	0.35442949820457	no	1622	0.338658427554827	1130	NA					Soluble protein of unknown function; deletion mutants are viable and have elevated levels of Ty1 retrotransposition and Ty1 cDNA	biological_process	molecular_function	cellular_component
YJR111C_p	YJR111C	YJR111C	hom	Uncharacterized	0.372955995300601	0.354590597730381	no	1623	0.346567896591515	1173	NA	FT	OXIDATION-REDUCTION PROCESS	MITOCHONDRION		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondria	biological_process	molecular_function	mitochondrion
YMR251W-A	YMR251W-A	HOR7	hom	Verified	0.372866006714461	0.354624086595558	no	1624	0.33728529079313	1120	NA	FT		ENDOPLASMIC RETICULUM|PLASMA MEMBRANE		Protein of unknown function; overexpression suppresses Ca2+ sensitivity of mutants lacking inositol phosphorylceramide mannosyltransferases Csg1p and Csh1p; transcription is induced under hyperosmotic stress and repressed by alpha factor; HOR7 has a paralog, DDR2, that arose from the whole genome duplication	plasma membrane organization	molecular_function	endoplasmic reticulum|plasma membrane
YCR077C	YCR077C	PAT1	hom	Verified	0.372635508175263	0.354709870760028	no	1625	0.366566682368131	1246	NA	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|TRANSLATION|CELL DIVISION|CHROMOSOME SEGREGATION	NUCLEUS	RIBOSOME	Deadenylation-dependent mRNA-decapping factor; also required for faithful chromosome transmission, maintenance of rDNA locus stability, and protection of mRNA 3'-UTRs from trimming; associated with topoisomerase II; functionally linked to Pab1p; forms cytoplasmic foci upon DNA replication stress	deadenylation-dependent decapping of nuclear-transcribed mRNA|chromosome segregation|regulation of translational initiation|formation of translation preinitiation complex|negative regulation of translational initiation|cytoplasmic mRNA processing body assembly	molecular_function	cytosolic small ribosomal subunit|cytoplasmic mRNA processing body
YLR065C	YLR065C	ENV10	hom	Verified	0.371673722809605	0.355067895903761	no	1626	0.365919840274838	1223	NA	FF|FT	VACUOLAR PROTEIN PROCESSING			Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing; YLR065C is not an essential gene	vacuolar protein processing	molecular_function	integral to membrane
YHR117W	YHR117W	TOM71	hom	Verified	0.371141870464586	0.35526593322119	no	1627	0.350429387537202	1161	NA	FT		MITOCHONDRION		Mitochondrial outer membrane protein; probable minor component of the TOM (translocase of outer membrane) complex responsible for recognition and import of mitochondrially directed proteins; TOM71 has a paralog, TOM70, that arose from the whole genome duplication	biological_process	protein transporter activity	mitochondrial outer membrane|mitochondrion|integral to membrane|integral to mitochondrial outer membrane
YPL164C	YPL164C	MLH3	hom	Verified	0.371013921623646	0.35531358131225	no	1628	0.356342634887628	1180	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Protein involved in DNA mismatch repair and crossing-over during meiotic recombination; forms a complex with Mlh1p; mammalian homolog is implicated mammalian microsatellite instability	mismatch repair|reciprocal meiotic recombination	molecular_function	nucleus|MutLbeta complex
YIL119C	YIL119C	RPI1	hom	Verified	0.370956007447041	0.355335149269351	no	1629	0.336698973342576	1118	NA	FT	SIGNALING	NUCLEUS		Transcription factor with allelic differences between S288C and Sigma1278b; mediates fermentation stress tolerance by modulating cell wall integrity; overexpression suppresses heat shock sensitivity of wild-type RAS2 overexpression and also suppresses cell lysis defect of mpk1 mutation; allele from S288c can confer fMAPK pathway independent transcription of FLO11; S288C and Sigma1278b alleles differ in number of tandem repeats within ORF	fungal-type cell wall biogenesis|Ras protein signal transduction|positive regulation of transcription from RNA polymerase II promoter	small GTPase regulator activity	nucleus
YPL272C_p	YPL272C	YPL272C	hom	Uncharacterized	0.370126573455223	0.355644091575724	no	1630	0.381917818894899	1273	NA					Putative protein of unknown function; gene expression induced in response to ketoconazole; YPL272C is not an essential gene	biological_process	molecular_function	cellular_component
YKL137W	YKL137W	CMC1	hom	Verified	0.369202436750183	0.35598841986197	no	1631	0.356088583381595	1198	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Evolutionarily conserved copper-binding protein of the mitochondrial intermembrane space, may be involved in delivering copper from the matrix to the cytochrome c oxidase complex; contains a twin CX9C motif	mitochondrial respiratory chain complex IV assembly	copper ion binding	extrinsic to mitochondrial inner membrane|mitochondrial intermembrane space
YML120C	YML120C	NDI1	hom	Verified	0.368994299551964	0.356065986866052	no	1632	0.340939258083391	1137	NA	FT	OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		NADH:ubiquinone oxidoreductase; transfers electrons from NADH to ubiquinone in the respiratory chain but does not pump protons, in contrast to the higher eukaryotic multisubunit respiratory complex I; phosphorylated; involved in Mn and H2O2 induced apoptosis; upon apoptotic stress, Ndip is activated in the mitochondria by N-terminal cleavage, and the truncated protein translocates to the cytoplasm to induce apoptosis; homolog of human AMID	mitochondrial electron transport, NADH to ubiquinone|NADH oxidation|chronological cell aging|positive regulation of apoptotic process	NADH dehydrogenase (ubiquinone) activity	mitochondrion|mitochondrial matrix
YLR041W_d	YLR041W	YLR041W	hom	Dubious	0.368838212445406	0.356124160143024	no	1633	0.342621284523723	1142	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YLR040C	Unknown	Unknown	Unknown
YJL024C	YJL024C	APS3	hom	Verified	0.368252596576792	0.356342447567914	no	1634	0.368723404598545	1220	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Small subunit of the clathrin-associated adaptor complex AP-3; involved in vacuolar protein sorting; related to the sigma subunit of the mammalian clathrin AP-3 complex; suppressor of loss of casein kinase 1 function; protein abundance increases in response to DNA replication stress	Golgi to vacuole transport|vesicle-mediated transport	molecular_function	AP-3 adaptor complex
YDR215C_d	YDR215C	YDR215C	hom	Dubious	0.368150329051804	0.356380572462942	no	1635	0.360274182017667	1168	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays elevated sensitivity to expression of a mutant huntingtin fragment or of alpha-synuclein	Unknown	Unknown	Unknown
YCR076C	YCR076C	FUB1	hom	Verified	0.367242828333641	0.356718947686167	no	1636	0.400086022167255	1300	NA					Putative protein of unknown function; interacts physically with multiple subunits of the 20S proteasome and genetically with genes encoding 20S core particle and 19S regulatory particle subunits; exhibits boundary activity which blocks the propagation of heterochromatic silencing; contains a PI31 proteasome regulator domain and sequence similarity with human PSMF1, a proteasome inhibitor; not an essential gene	biological_process	proteasome binding	cellular_component
YML034C-A_d	YML034C-A	YML034C-A	hom	Dubious	0.366408028553273	0.357030314880939	no	1637	0.37864578406895	1255	NA					Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YML073C	YML073C	RPL6A	hom	Verified	0.36531099017478	0.357439637759068	no	1638	0.331452997490876	1092	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L6A; N-terminally acetylated; binds 5.8S rRNA; homologous to mammalian ribosomal protein L6, no bacterial homolog; RPL6A has a paralog, RPL6B, that arose from the whole genome duplication	cytoplasmic translation|ribosomal large subunit assembly	structural constituent of ribosome|RNA binding	cytosolic large ribosomal subunit
YKL118W_d	YKL118W	YKL118W	hom	Dubious	0.365134116873626	0.357505647437384	no	1639	0.442733041514731	1455	NA	FF				Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene VPH2	Unknown	Unknown	Unknown
YMR119W	YMR119W	ASI1	hom	Verified	0.364875743218167	0.35760208096896	no	1640	0.405928175037217	1347	NA	FT	PROTEOLYSIS	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM		Putative integral membrane E3 ubiquitin ligase; acts with Asi2p and Asi3p to ensure the fidelity of SPS-sensor signalling by maintaining the dormant repressed state of gene expression in the absence of inducing signals; ASI1 has a paralog, ASI3, that arose from the whole genome duplication	ubiquitin-dependent protein catabolic process	ubiquitin-protein ligase activity	integral to membrane|nuclear inner membrane|endoplasmic reticulum membrane
YJR001W	YJR001W	AVT1	hom	Verified	0.364151935474928	0.357872278175623	no	1641	0.380567064465497	1256	NA	FT	VACUOLAR TRANSPORT			Vacuolar transporter, imports large neutral amino acids into the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters	amino acid transport|vacuolar transport	transporter activity|L-glutamine transmembrane transporter activity|L-isoleucine transmembrane transporter activity|L-tyrosine transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane|fungal-type vacuole
YHR043C	YHR043C	DOG2	hom	Verified	0.362795043396802	0.358378997393036	no	1642	0.347569242407295	1158	NA	FT	CARBOHYDRATE METABOLISM	NUCLEUS		2-deoxyglucose-6-phosphate phosphatase; member of a family of low molecular weight phosphatases, paralogous to DOG1, induced by oxidative and osmotic stress, confers 2-deoxyglucose resistance when overexpressed	glucose metabolic process	2-deoxyglucose-6-phosphatase activity	nucleus|cytoplasm
YGL139W	YGL139W	FLC3	hom	Verified	0.362261496968206	0.35857831392552	no	1643	0.350705398294397	1149	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION		Putative FAD transporter, similar to Flc1p and Flc2p; localized to the ER	FAD transport|transmembrane transport	FAD transmembrane transporter activity	mitochondrion|integral to membrane|endoplasmic reticulum
YLR432W	YLR432W	IMD3	hom	Verified	0.361738737511107	0.35877363814535	no	1644	0.388067801727543	1293	NA	FT	OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM			Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, member of a four-gene family in S. cerevisiae, constitutively expressed	GTP biosynthetic process	IMP dehydrogenase activity	plasma membrane|cytoplasm
YDR368W	YDR368W	YPR1	hom	Verified	0.360846584049026	0.359107068297659	no	1645	0.358810689431656	1213	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		NADPH-dependent aldo-keto reductase; reduces multiple substrates including 2-methylbutyraldehyde and D,L-glyceraldehyde, expression is induced by osmotic and oxidative stress; functionally redundant with other aldo-keto reductases; protein abundance increases in response to DNA replication stress; YPR1 has a paralog, GCY1, that arose from the whole genome duplication	cellular response to oxidative stress|D-xylose catabolic process|arabinose catabolic process	glucose 1-dehydrogenase (NADP+) activity|alditol:NADP+ 1-oxidoreductase activity|carbonyl reductase (NADPH) activity	nucleus|cytoplasm
YNL248C	YNL248C	RPA49	hom	Verified	0.357962879969967	0.360185546408497	no	1646	0.335371614778631	1136	NA	FT		NUCLEUS		RNA polymerase I subunit A49	transcription elongation from RNA polymerase I promoter|transcription of nuclear large rRNA transcript from RNA polymerase I promoter|regulation of cell size	molecular_function	DNA-directed RNA polymerase I complex
YNL095C_p	YNL095C	YNL095C	hom	Uncharacterized	0.357566026597267	0.360334053191388	no	1647	0.355698439371136	1207	NA					Putative protein of unknown function; predicted to contain a transmembrane domain; not an essential gene; YNL095C has a paralog, ECM3, that arose from the whole genome duplication	biological_process	molecular_function	integral to membrane
YPR115W	YPR115W	RGC1	hom	Verified	0.357380210305875	0.360403594883226	no	1648	0.366909609331113	1199	NA	FT	CELL CYCLE			Pleckstrin homology domain containing protein; proposed to function as a glycerol channel activator; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; RGC1 has a paralog, ASK10, that arose from the whole genome duplication	positive regulation of glycerol transport	molecular_function	cytoplasm
YML099C	YML099C	ARG81	hom	Verified	0.357280304681062	0.360440986442776	no	1649	0.352955853412477	1205	NA	FT	VESICLE-MEDIATED TRANSPORT|TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type, involved in the regulation of arginine-responsive genes; acts with Arg80p and Arg82p	arginine metabolic process|negative regulation of calcium ion-dependent exocytosis	transcription cofactor activity	nucleus
YGR077C	YGR077C	PEX8	hom	Verified	0.356623065065082	0.360687003989791	no	1650	0.303460020317374	1037	NA	FT	PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION			Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p	protein targeting to peroxisome|peroxisome organization	peroxisome targeting sequence binding	peroxisomal matrix|peroxisomal membrane|extrinsic to intraperoxisomal membrane
YBL095W_p	YBL095W	YBL095W	hom	Uncharacterized	0.356237112365083	0.36083150046011	no	1651	0.327690334999685	1131	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YDR006C	YDR006C	SOK1	hom	Verified	0.355179178731295	0.361227681059406	no	1652	0.348378203484983	1172	NA	FT	SIGNALING	NUCLEUS		Protein whose overexpression suppresses the growth defect of mutants lacking protein kinase A activity; involved in cAMP-mediated signaling; localized to the nucleus; similar to the mouse testis-specific protein PBS13	cAMP-mediated signaling	molecular_function	nucleus
YOL052C-A	YOL052C-A	DDR2	hom	Verified	0.354909780346175	0.361328590596438	no	1653	0.361020760771085	1207	NA					Multi-stress response protein; expression is activated by a variety of xenobiotic agents and environmental or physiological stresses; DDR2 has a paralog, HOR7, that arose from the whole genome duplication	response to stress	molecular_function	fungal-type vacuole|cytoplasm
YLR374C_d	YLR374C	YLR374C	hom	Dubious	0.354794920722573	0.36137161691936	no	1654	0.406708264512032	1333	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF STP3/YLR375W	Unknown	Unknown	Unknown
YER014W	YER014W	HEM14	hom	Verified	0.354603824896728	0.361443205147655	no	1655	0.376109709445845	1233	NA	FT	OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM	MITOCHONDRION		Protoporphyrinogen oxidase, a mitochondrial enzyme that catalyzes the seventh step in the heme biosynthetic pathway, converting protoporphyrinogen IX to protoporphyrin IX; inhibited by diphenyl ether-type herbicides	heme biosynthetic process	oxygen-dependent protoporphyrinogen oxidase activity	mitochondrion|mitochondrial inner membrane
YHR060W	YHR060W	VMA22	hom	Verified	0.354582874801374	0.361451053757629	no	1656	0.370398882644574	1225	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|ION HOMEOSTASIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Peripheral membrane protein that is required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the yeast endoplasmic reticulum (ER)	vacuolar proton-transporting V-type ATPase complex assembly|vacuolar acidification	unfolded protein binding	extrinsic to endoplasmic reticulum membrane
YMR295C	YMR295C	YMR295C	hom	Verified	0.354105406821186	0.361629945113995	no	1657	0.350459617552325	1167	NA	FT		SITE OF POLARIZED GROWTH		Protein of unknown function that associates with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and bud; YMR295C is not an essential gene; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	ribosome|cellular bud|mating projection tip
YNR025C_d	YNR025C	YNR025C	hom	Dubious	0.353821097257085	0.361736480813002	no	1658	0.366341694767859	1230	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion reduces expression of PIS1 gene encoding phosphatidylinositol synthase	Unknown	Unknown	Unknown
YDR033W	YDR033W	MRH1	hom	Verified	0.353295995387483	0.361933273714631	no	1659	0.362347477770894	1209	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION|PLASMA MEMBRANE		Protein that localizes primarily to the plasma membrane; also found at the nuclear envelope; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; MRH1 has a paralog, YRO2, that arose from the whole genome duplication	biological_process	molecular_function	mitochondrion|integral to membrane|plasma membrane
YCR028C-A	YCR028C-A	RIM1	hom	Verified	0.353046119214911	0.362026932857491	no	1660	0.391333294883559	1296	NA	FT	MITOCHONDRION ORGANIZATION	MITOCHONDRION		Single-stranded DNA-binding protein essential for mitochondrial genome maintenance; involved in mitochondrial DNA replication	mitochondrial DNA replication|mitochondrial genome maintenance	single-stranded DNA binding	mitochondrial nucleoid|mitochondrion
YMR194C-B	YMR194C-B	CMC4	hom	Verified	0.35276192357526	0.362133465742051	no	1661	0.351902845641255	1137	NA	FT		MITOCHONDRION		Protein that localizes to the mitochondrial intermembrane space via the Mia40p-Erv1p system; contains twin cysteine-x(9)-cysteine motifs	biological_process	molecular_function	mitochondrial intermembrane space
YDR536W	YDR536W	STL1	hom	Verified	0.350125980157544	0.363122077028671	no	1662	0.349363865084759	1177	NA	FT		PLASMA MEMBRANE		Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock	transport|glycerol transport|transmembrane transport	solute:hydrogen symporter activity|transporter activity	integral to membrane|plasma membrane|membrane
YGR167W	YGR167W	CLC1	hom	Verified	0.348353480369136	0.363787367201958	no	1663	0.385591157198553	1274	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS|PLASMA MEMBRANE		Clathrin light chain; subunit of the major coat protein involved in intracellular protein transport and endocytosis; thought to regulate clathrin function; two Clathrin heavy chains (CHC1) form the clathrin triskelion structural component; YGR167W	endocytosis|vesicle-mediated transport	structural molecule activity	clathrin vesicle coat
YLR185W	YLR185W	RPL37A	hom	Verified	0.348328637344641	0.363796694708513	no	1664	0.353366165770727	1169	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L37A; homologous to mammalian ribosomal protein L37, no bacterial homolog; RPL37A has a paralog, RPL37B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YDR329C	YDR329C	PEX3	hom	Verified	0.346106201321776	0.364631451569934	no	1665	0.370475417125212	1232	NA	FT	PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION	ENDOPLASMIC RETICULUM		Peroxisomal membrane protein (PMP) required for proper localization and stability of PMPs; anchors peroxisome retention factor Inp1p at the peroxisomal membrane; interacts with Pex19p	protein import into peroxisome membrane|peroxisome inheritance|ER-dependent peroxisome organization	protein binding	peroxisomal membrane|endoplasmic reticulum
YJR056C	YJR056C	YJR056C	hom	Verified	0.345280387105115	0.364941794944346	no	1666	0.324570087500646	1102	NA	FT		NUCLEUS		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; relative distribution to the nucleus increases upon DNA replication stress	biological_process	molecular_function	nucleus|cytoplasm
YER032W	YER032W	FIR1	hom	Verified	0.345244025492885	0.364955461779145	no	1667	0.390707792162286	1304	NA	FT	RNA PROCESSING	SITE OF POLARIZED GROWTH		Protein involved in 3' mRNA processing, interacts with Ref2p; potential Cdc28p substrate	mRNA polyadenylation|RNA polyadenylation	molecular_function	cellular bud neck
YPL195W	YPL195W	APL5	hom	Verified	0.344043576369398	0.365406757477201	no	1668	0.382519373193842	1254	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Delta adaptin-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway, suppressor of loss of casein kinase 1 function	vesicle-mediated transport|Golgi to vacuole transport	protein binding	AP-3 adaptor complex
YLR089C	YLR089C	ALT1	hom	Verified	0.343190512003447	0.365727571025032	no	1669	0.3699328630704	1211	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		Alanine transaminase (glutamic pyruvic transaminase); involved in alanine biosynthetic and catabolic processes; expression is induced in the presence of alanine; repression is mediated by Nrg1p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; paralogous gene ALT2 is catalytically inactive	alanine catabolic process|alanine biosynthetic process	L-alanine:2-oxoglutarate aminotransferase activity	mitochondrion
YDL151C_d	YDL151C	BUD30	hom	Dubious	0.341267268447922	0.366451193212439	no	1670	0.379235327100621	1244	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 96% of ORF overlaps the verified gene RPC53; diploid mutant displays a weak budding pattern phenotype in a systematic assay	Unknown	Unknown	Unknown
YPL141C	YPL141C	FRK1	hom	Verified	0.339567665506173	0.36709106592731	no	1671	0.368340230725701	1232	NA	FT	PROTEIN PHOSPHORYLATION			Protein kinase of unknown cellular role; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; interacts with rRNA transcription and ribosome biogenesis factors and the long chain fatty acyl-CoA synthetase Faa3p; FRK1 has a paralog, KIN4, that arose from the whole genome duplication	protein phosphorylation	protein kinase activity	cytoplasm
YHR151C	YHR151C	MTC6	hom	Verified	0.338773176933089	0.367390304680244	no	1672	0.373758907079556	1247	NA					Protein of unknown function; mtc6 is synthetically sick with cdc13-1	biological_process	molecular_function	cellular_component
YDR173C	YDR173C	ARG82	hom	Verified	0.338395232111698	0.367532683327624	no	1673	0.349997911428776	1158	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|LIPID METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Inositol polyphosphate multikinase (IPMK), sequentially phosphorylates Ins(1,4,5)P3 to form Ins(1,3,4,5,6)P5; also has diphosphoinositol polyphosphate synthase activity; regulates arginine-, phosphate-, and nitrogen-responsive genes	protein stabilization|negative regulation of transcription from RNA polymerase II promoter|phosphatidylinositol phosphorylation|regulation of arginine metabolic process|inositol phosphate biosynthetic process|positive regulation of transcription from RNA polymerase II promoter	inositol-1,4,5-trisphosphate 3-kinase activity|inositol-1,4,5-trisphosphate 6-kinase activity|phosphatidylinositol 3-kinase activity|protein binding, bridging|inositol tetrakisphosphate 6-kinase activity|inositol tetrakisphosphate 3-kinase activity|inositol-1,3,4,5,6-pentakisphosphate kinase activity	nucleus
YPL219W	YPL219W	PCL8	hom	Verified	0.337036057261986	0.368044859440681	no	1674	0.379282750777919	1265	NA	FT	CELL CYCLE|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS		Cyclin, interacts with Pho85p cyclin-dependent kinase (Cdk) to phosphorylate and regulate glycogen synthase, also activates Pho85p for Glc8p phosphorylation	negative regulation of glycogen biosynthetic process	cyclin-dependent protein kinase regulator activity	cyclin-dependent protein kinase holoenzyme complex
YHR194W	YHR194W	MDM31	hom	Verified	0.336556048303993	0.368225796717431	no	1675	0.398075465816824	1329	NA	FT	ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS	NUCLEUS|MITOCHONDRION		Mitochondrial protein that may have a role in phospholipid metabolism; inner membrane protein with similarity to Mdm32p; required for normal mitochondrial morphology and inheritance; interacts genetically with MMM1, MMM2, MDM10, MDM12, and MDM34	mitochondrion inheritance|cellular ion homeostasis|mitochondrion organization|Unknown	molecular_function	mitochondrial inner membrane|nucleus
YDR135C	YDR135C	YCF1	hom	Verified	0.336525415327685	0.368237344676536	no	1676	0.347286636780918	1164	NA	FT	NUCLEOTIDE METABOLISM			Vacuolar glutathione S-conjugate transporter; member of the ATP-binding cassette family; has a role in detoxifying metals such as cadmium, mercury, and arsenite; also transports unconjugated bilirubin, selenodigluthatione, and oxidized glutathione; similar to human cystic fibrosis protein CFTR	bilirubin transport|response to metal ion|transmembrane transport	bilirubin transmembrane transporter activity|glutathione S-conjugate-exporting ATPase activity	fungal-type vacuole membrane|integral to membrane
YNL141W	YNL141W	AAH1	hom	Verified	0.336293240332002	0.368324873419107	no	1677	0.372902088764186	1235	NA	FT	NUCLEOTIDE METABOLISM	NUCLEUS		Adenine deaminase (adenine aminohydrolase), converts adenine to hypoxanthine; involved in purine salvage; transcriptionally regulated by nutrient levels and growth phase; Aah1p degraded upon entry into quiescence via SCF and the proteasome	adenine catabolic process|hypoxanthine salvage|purine-containing compound salvage	adenine deaminase activity	nucleus|cytoplasm
YJL160C_p	YJL160C	YJL160C	hom	Uncharacterized	0.336169177194055	0.36837164736641	no	1678	0.393539243680258	1313	NA					Putative protein of unknown function; member of the PIR (proteins with internal repeats) family of cell wall proteins; non-essential gene that is required for sporulation; mRNA is weakly cell cycle regulated, peaking in mitosis; YJL160C has a paralog, PIR1, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YPR046W	YPR046W	MCM16	hom	Verified	0.336136603315256	0.36838392860509	no	1679	0.402502329300918	1338	NA	FT	CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME	KINETOCHORE	Component of the Ctf19 complex and the COMA subcomplex; involved in kinetochore-microtubule mediated chromosome segregation; binds to centromere DNA; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-H and fission yeast fta3	chromosome segregation|establishment of mitotic sister chromatid cohesion	molecular_function	condensed nuclear chromosome kinetochore
YDR076W	YDR076W	RAD55	hom	Verified	0.335609349405751	0.368582736372039	no	1680	0.395572192940166	1323	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS		Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad57p	DNA recombinase assembly|heteroduplex formation|meiotic DNA recombinase assembly|double-strand break repair via single-strand annealing	DNA-dependent ATPase activity|protein heterodimerization activity	nucleus|Rhp55-Rhp57 complex
YJL187C	YJL187C	SWE1	hom	Verified	0.335393708784926	0.368664056540199	no	1681	0.35339236545623	1173	NA	FT	CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION	NUCLEUS|SITE OF POLARIZED GROWTH		Protein kinase that regulates the G2/M transition by inhibition of Cdc28p kinase activity; localizes to the nucleus and to the daughter side of the mother-bud neck; homolog of S. pombe Wee1p; potential Cdc28p substrate	negative regulation of spindle pole body separation|G2/M transition size control checkpoint|protein phosphorylation|re-entry into mitotic cell cycle|G2/M transition of mitotic cell cycle|cell shape checkpoint|regulation of cyclin-dependent protein kinase activity|regulation of cell size|regulation of meiosis	protein tyrosine kinase activity|protein kinase activity	nucleus|cellular bud neck
YDR185C	YDR185C	UPS3	hom	Verified	0.334718449953585	0.368918741220708	no	1682	0.370908521386944	1225	NA	FT	MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial protein of unknown function; similar to Ups1p and Ups2p which are involved in regulation of mitochondrial cardiolipin and phosphatidylethanolamine levels; null is viable but interacts synthetically with ups1 and ups2 mutations	mitochondrion morphogenesis	molecular_function	extrinsic to mitochondrial inner membrane|mitochondrion|mitochondrial intermembrane space
YDR335W	YDR335W	MSN5	hom	Verified	0.334617045868015	0.368956992369654	no	1683	0.383436246970538	1276	NA	FT	PROTEIN LOCALIZATION|RNA LOCALIZATION	NUCLEUS		Karyopherin involved in nuclear import and export of proteins, including import of replication protein A and export of Swi6p, Far1p, and Pho4p; required for re-export of mature tRNAs after their retrograde import from the cytoplasm	tRNA re-export from nucleus|protein export from nucleus	protein binding|importin-alpha export receptor activity	integral to membrane|nucleus|cytoplasm
YDL177C_p	YDL177C	YDL177C	hom	Uncharacterized	0.333466640384456	0.369391033454401	no	1684	0.353059343628049	1184	NA					Putative protein of unknown function; similar to the mouse IMPACT gene; YDL177C is not an essential gene	biological_process	molecular_function	cellular_component
YGR035W-A_p	YGR035W-A	YGR035W-A	hom	Uncharacterized	0.333323841155618	0.369444922376095	no	1685	0.354950540165935	1190	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YHR086W	YHR086W	NAM8	hom	Verified	0.333204262259322	0.369490050487982	no	1686	0.37726158974704	1227	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING	NUCLEUS|MITOCHONDRION		RNA binding protein, component of the U1 snRNP protein; mutants are defective in meiotic recombination and in formation of viable spores, involved in the formation of DSBs through meiosis-specific splicing of REC107 pre-mRNA; Nam8p regulon embraces the meiotic pre-mRNAs of REC107, HFM1, AMA1 SPO22 and PCH2; the putative RNA binding domains RRM2 and RRM3 are required for Nam8p meiotic function	mRNA splicing, via spliceosome|positive regulation of mRNA splicing, via spliceosome|mRNA splice site selection	mRNA binding|RNA binding	commitment complex|U1 snRNP|U2-type prespliceosome
YNL054W	YNL054W	VAC7	hom	Verified	0.332168577138257	0.369880984875696	no	1687	0.306164621157671	1056	NA	FT	LIPID METABOLISM			Integral vacuolar membrane protein involved in vacuole inheritance and morphology; activates Fab1p kinase activity under basal conditions and also after hyperosmotic shock	positive regulation of phosphatidylinositol biosynthetic process|positive regulation of kinase activity	molecular_function	fungal-type vacuole membrane|integral to membrane|PAS complex|vacuolar membrane|cytoplasm
YGL216W	YGL216W	KIP3	hom	Verified	0.330336362216801	0.370572910241207	no	1688	0.344857133483921	1169	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CYTOSKELETON ORGANIZATION	NUCLEUS|CYTOSKELETON		Kinesin-related motor protein involved in mitotic spindle positioning	nuclear migration along microtubule|mitotic spindle disassembly|establishment of mitotic spindle orientation|plus-end specific microtubule depolymerization|mitotic spindle organization in nucleus	plus-end-directed microtubule motor activity|tubulin-dependent ATPase activity	kinesin complex|cytoplasmic microtubule|nuclear microtubule
YDL006W	YDL006W	PTC1	hom	Verified	0.330192813271765	0.370627138392736	no	1689	0.406654698243819	1356	NA	FF|FT	RNA PROCESSING|SIGNALING|MITOCHONDRION ORGANIZATION|PROTEIN PHOSPHORYLATION	NUCLEUS		Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p, inactivating osmosensing MAPK cascade; involved in Fus3p activation during pheromone response; deletion affects precursor tRNA splicing, mitochondrial inheritance, and sporulation	mitochondrion inheritance|inactivation of MAPK activity involved in osmosensory signaling pathway|pheromone-dependent signal transduction involved in conjugation with cellular fusion|tRNA splicing, via endonucleolytic cleavage and ligation|protein dephosphorylation	protein serine/threonine phosphatase activity	nucleus|cytoplasm
YBR266C_d	YBR266C	SLM6	hom	Dubious	0.329937808869608	0.370723477151573	no	1690	0.378356816708735	1234	NA					Protein with a potential role in actin cytoskeleton organization; gene exhibits synthetic genetic interaction with MSS4 encoding phosphatidylinositol 4-phosphate kinase	Unknown	Unknown	Unknown
YMR247W-A_p	YMR247W-A	YMR247W-A	hom	Uncharacterized	0.329857346399409	0.37075387695456	no	1691	0.363871498748766	1195	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YDL080C	YDL080C	THI3	hom	Verified	0.327443540834009	0.371666219526839	no	1692	0.366073720994777	1202	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Probable alpha-ketoisocaproate decarboxylase, may have a role in catabolism of amino acids to long-chain and complex alcohols; required for expression of enzymes involved in thiamine biosynthesis	regulation of thiamine biosynthetic process|branched-chain amino acid catabolic process to alcohol via Ehrlich pathway|positive regulation of transcription from RNA polymerase II promoter|leucine catabolic process	carboxy-lyase activity	cytosol|nucleus
YOL086W-A	YOL086W-A	MHF1	hom	Verified	0.327257477879279	0.371736575477765	no	1693	0.353158741021217	1201	NA	FT	RESPONSE TO DNA DAMAGE			Component of the heterotetrameric MHF histone-fold complex; in humans the MMF complex interacts with both DNA and Mph1p ortholog FANCM, a Fanconi anemia complementation group protein, to stabilize and remodel blocked replication forks and repair damaged DNA; mhf1 srs2 double mutants are MMS hypersensitive; ortholog of human centromere constitutive-associated network (CCAN) subunit CENP-S, also known as MHF1	response to DNA damage stimulus	molecular_function	cellular_component
YOR027W	YOR027W	STI1	hom	Verified	0.327188670645155	0.371762594629785	no	1694	0.381014938116315	1276	NA					Hsp90 cochaperone, interacts with the Ssa group of the cytosolic Hsp70 chaperones and activates Ssa1p ATPase activity; interacts with Hsp90 chaperones and inhibits their ATPase activity; homolog of mammalian Hop	protein folding	Hsp70 protein binding|Hsp90 protein binding|mRNA binding|ATPase inhibitor activity	cytoplasm
YMR272W-B_p	YMR272W-B	YMR272W-B	hom	Uncharacterized	0.32689294899981	0.371874427132724	no	1695	0.333858478681017	1130	NA					Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching	biological_process	molecular_function	cellular_component
YER176W	YER176W	ECM32	hom	Verified	0.326786949936775	0.371914515233234	no	1696	0.353090502940954	1204	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION			DNA dependent ATPase/DNA helicase belonging to the Dna2p- and Nam7p-like family of helicases that is involved in modulating translation termination; interacts with the translation termination factors, localized to polysomes	regulation of translational termination	RNA helicase activity|DNA helicase activity	polysome
YOR273C	YOR273C	TPO4	hom	Verified	0.32610890226929	0.372170980929252	no	1697	0.468172940190643	1573	NA	FF|FT		PLASMA MEMBRANE		Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; recognizes spermine, putrescine, and spermidine; localizes to the plasma membrane	spermidine transport|spermine transport	spermidine transmembrane transporter activity|spermine transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane|plasma membrane
YPL225W	YPL225W	YPL225W	hom	Verified	0.326033009048048	0.372199690418422	no	1698	0.373486900757089	1237	NA					Protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	ribosome|cytoplasm
YGL226C-A	YGL226C-A	OST5	hom	Verified	0.325788042600059	0.372292363114021	no	1699	0.371819766278087	1253	NA	FT	CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Zeta subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins	protein N-linked glycosylation	dolichyl-diphosphooligosaccharide-protein glycotransferase activity	oligosaccharyltransferase complex
YER010C	YER010C	YER010C	hom	Verified	0.324777546270295	0.372674719792136	no	1700	0.371155733258576	1235	NA					Protein of unknown function, forms a ring-shaped homotrimer; has similarity to members of the prokaryotic rraA family; possibly involved in a phosphotransfer reaction	biological_process	molecular_function	cellular_component
YBL022C	YBL022C	PIM1	hom	Verified	0.324526858075952	0.372769595894194	no	1701	0.408760339425327	1346	NA	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS|MITOCHONDRION ORGANIZATION|RESPONSE TO OXIDATIVE STRESS	MITOCHONDRION		ATP-dependent Lon protease, involved in degradation of misfolded proteins in mitochondria; required for biogenesis and maintenance of mitochondria	chaperone-mediated protein complex assembly|misfolded or incompletely synthesized protein catabolic process	ATP-dependent peptidase activity	mitochondrion|mitochondrial matrix
YLR326W_p	YLR326W	YLR326W	hom	Uncharacterized	0.324276103846998	0.372864504709896	no	1702	0.358215445826198	1168	NA					Putative protein of unknown function, predicted to be palmitoylated	biological_process	molecular_function	cellular_component
YKL085W	YKL085W	MDH1	hom	Verified	0.323927879212383	0.372996318228398	no	1703	0.37717859547957	1219	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Mitochondrial malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the tricarboxylic acid (TCA) cycle; phosphorylated	chronological cell aging|replicative cell aging|tricarboxylic acid cycle|aerobic respiration	L-malate dehydrogenase activity|mRNA binding	mitochondrion|mitochondrial matrix
YIR043C	YIR043C	YIR043C	hom	pseudogene	0.32367085535759	0.373093619041908	no	1704	0.373639221373147	1245	NA					Possible pseudogene in strain S288C; YIR043C and the adjacent ORF, YIR044C, together may encode a non-functional member of the conserved, often subtelomerically-encoded Cos protein family	biological_process	molecular_function	cellular_component
YEL012W	YEL012W	UBC8	hom	Verified	0.32308383644308	0.373315875524428	no	1705	0.369032894597543	1206	NA	FT	KETONE METABOLISM|CARBOHYDRATE METABOLISM|PROTEOLYSIS			Ubiquitin-conjugating enzyme that negatively regulates gluconeogenesis by mediating the glucose-induced ubiquitination of fructose-1,6-bisphosphatase (FBPase); cytoplasmic enzyme that catalyzes the ubiquitination of histones in vitro	negative regulation of gluconeogenesis|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein polyubiquitination|protein monoubiquitination	ubiquitin-protein ligase activity	cytoplasm
YNL047C	YNL047C	SLM2	hom	Verified	0.322176851747165	0.373659359975095	no	1706	0.350088664237551	1165	NA	FT	VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|SIGNALING|CYTOSKELETON ORGANIZATION	PLASMA MEMBRANE		Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm1p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; phosphorylated by the TORC2 complex; SLM2 has a paralog, SLM1, that arose from the whole genome duplication	eisosome assembly|TOR signaling cascade|regulation of cell growth|actin filament bundle assembly|endosomal transport|establishment or maintenance of actin cytoskeleton polarity|actin cytoskeleton organization	phosphatidylinositol binding	plasma membrane
YGL177W_d	YGL177W	YGL177W	hom	Dubious	0.32158184830548	0.37388474845381	no	1707	0.404474300325723	1349	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDL213C	YDL213C	NOP6	hom	Verified	0.321170740464573	0.37404050211526	no	1708	0.37595430330996	1237	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		rRNA-binding protein required for 40S ribosomal subunit biogenesis; contains an RNA recognition motif (RRM); hydrophilin essential to overcome the stress of the desiccation-rehydration process; NOP6 may be a fungal-specific gene as no homologs have been yet identified in higher eukaryotes	ribosomal small subunit biogenesis	RNA binding|rRNA binding	nucleolus|90S preribosome
YKL181W	YKL181W	PRS1	hom	Verified	0.321067551305522	0.374079599927521	no	1709	0.374010428281543	1250	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM			5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes	fungal-type cell wall organization|5-phosphoribose 1-diphosphate biosynthetic process	ribose phosphate diphosphokinase activity	cytoplasm
YDR222W_p	YDR222W	YDR222W	hom	Uncharacterized	0.320202069473989	0.374407577254359	no	1710	0.401111375078317	1316	NA	FT	RESPONSE TO OXIDATIVE STRESS			Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern	biological_process	molecular_function	cytoplasm
YLR168C	YLR168C	UPS2	hom	Verified	0.320046559431373	0.37446651796238	no	1711	0.378381420679802	1274	NA	FT	LIPID METABOLISM|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial protein involved in phospholipid metabolism; localizes to the intermembrane space; has a role in regulation of phospholipid metabolism by inhibiting conversion of phosphatidylethanolamine to phosphatidylcholine; null mutant has defects in mitochondrial morphology; similar to Ups1p, Ups3p and to human PRELI	cristae formation|Unknown|phosphatidylethanolamine metabolic process|cardiolipin metabolic process	molecular_function	extrinsic to mitochondrial inner membrane|mitochondrion|mitochondrial intermembrane space
YML007C-A_p	YML007C-A	YML007C-A	hom	Uncharacterized	0.319777747217906	0.374568408860626	no	1712	0.384855880953959	1299	NA	FF|FT		MITOCHONDRION		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria	biological_process	molecular_function	mitochondrion
YNL123W	YNL123W	NMA111	hom	Verified	0.317929804955938	0.375269091796354	no	1713	0.415198058150511	1365	NA	FT	LIPID METABOLISM|PROTEOLYSIS	NUCLEUS		Serine protease and general molecular chaperone; involved in response to heat stress and promotion of apoptosis; may contribute to lipid homeostasis; sequence similarity to the mammalian Omi/HtrA2 family of serine proteases	apoptotic process|cellular lipid metabolic process|protein catabolic process|cellular response to heat	serine-type peptidase activity	nucleus
YJR032W	YJR032W	CPR7	hom	Verified	0.317473681576741	0.375442103215942	no	1714	0.386405135134926	1288	NA					Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity	protein refolding|response to stress	unfolded protein binding|peptidyl-prolyl cis-trans isomerase activity	cytosol
YBL062W_d	YBL062W	YBL062W	hom	Dubious	0.315647814166896	0.376134920589629	no	1715	0.402855670530811	1347	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YPL202C	YPL202C	AFT2	hom	Verified	0.315377503205727	0.376237522889613	no	1716	0.335991295630887	1131	NA	FT	TRANSCRIPTION FROM RNA POL II|ION HOMEOSTASIS|ION HOMEOSTASIS|RESPONSE TO NUTRIENT LEVELS|RESPONSE TO OXIDATIVE STRESS	NUCLEUS|MITOCHONDRION		Iron-regulated transcriptional activator; activates genes involved in intracellular iron use and required for iron homeostasis and resistance to oxidative stress; AFT2 has a paralog, AFT1, that arose from the whole genome duplication	cellular response to oxidative stress|cellular iron ion homeostasis|positive regulation of transcription from RNA polymerase II promoter in response to iron ion starvation|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	mitochondrion|nucleus
YNL121C	YNL121C	TOM70	hom	Verified	0.315268126289346	0.376279041721027	no	1717	0.399818289138636	1312	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Component of the TOM (translocase of outer membrane) complex; involved in the recognition and initial import steps for all mitochondrially directed proteins; acts as a receptor for incoming precursor proteins; TOM70 has a paralog, TOM71, that arose from the whole genome duplication	protein import into mitochondrial matrix|protein import into mitochondrial inner membrane	mitochondrion targeting sequence binding|protein channel activity	mitochondrial outer membrane|mitochondrion|integral to membrane|integral to mitochondrial outer membrane|mitochondrial outer membrane translocase complex
YGR142W	YGR142W	BTN2	hom	Verified	0.31418677840937	0.376689591964522	no	1718	0.377588085338534	1258	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|ION HOMEOSTASIS|ION HOMEOSTASIS			v-SNARE binding protein; facilitates specific protein retrieval from a late endosome to the Golgi; modulates arginine uptake, possible role in mediating pH homeostasis between the vacuole and plasma membrane H(+)-ATPase; BTN2 has a paralog, CUR1, that arose from the whole genome duplication	intracellular protein transport|amino acid transport|retrograde transport, endosome to Golgi|regulation of pH	SNARE binding	cytosol|late endosome|perinuclear region of cytoplasm
YHR159W_p	YHR159W	TDA11	hom	Uncharacterized	0.314043075064278	0.376744161645962	no	1719	0.390214194926957	1282	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; potential Cdc28p substrate; null mutant is sensitive to expression of the top1-T722A allele	biological_process	molecular_function	cytoplasm
YKR082W	YKR082W	NUP133	hom	Verified	0.313272362255313	0.377036872909597	no	1720	0.376420700833716	1234	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport and NPC biogenesis and is involved in establishment of a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p; also plays roles in several processes that may require localization of genes or chromosomes at the nuclear periphery, including double-strand break repair, transcription and chromatin silencing; homologous to human NUP133	poly(A)+ mRNA export from nucleus|double-strand break repair|maintenance of chromatin silencing at telomere|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|tRNA export from nucleus|telomere tethering at nuclear periphery|nuclear pore distribution|mRNA export from nucleus in response to heat stress|positive regulation of transcription, DNA-dependent|negative regulation of transcription from RNA polymerase II promoter|protein import into nucleus|positive regulation of transcription from RNA polymerase II promoter|chromatin silencing at silent mating-type cassette	structural constituent of nuclear pore	integral to membrane|nuclear pore|nuclear pore outer ring
YNL066W	YNL066W	SUN4	hom	Verified	0.313009833113218	0.377136595764162	no	1721	0.401990227869235	1332	NA	FT	CELL CYCLE|CELL WALL ORG/BIOGENESIS|CELL DIVISION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Cell wall protein related to glucanases, possibly involved in cell wall septation; member of the SUN family	mitochondrion organization	glucosidase activity	fungal-type cell wall|mitochondrial matrix
YMR072W	YMR072W	ABF2	hom	Verified	0.312891646138598	0.377181492284094	no	1722	0.383593590215423	1261	NA	FT	MITOCHONDRION ORGANIZATION	NUCLEUS|MITOCHONDRION|CHROMOSOME		Mitochondrial DNA-binding protein involved in mitochondrial DNA replication and recombination, member of HMG1 DNA-binding protein family; activity may be regulated by protein kinase A phosphorylation	mitochondrion inheritance|mitochondrial DNA packaging|mitochondrial genome maintenance	DNA binding, bending|DNA binding	mitochondrial nucleoid|mitochondrial chromosome|mitochondrion
YLR412W	YLR412W	BER1	hom	Verified	0.312243870362769	0.377427596911652	no	1723	0.372150910997166	1284	NA	FT		CYTOSKELETON		Protein involved in microtubule-related processes, N-acetylation; GFP-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YLR412W is not an essential gene; similar to Arabidopsis SRR1 gene	biological_process	molecular_function	cytoplasm
YGL007W_d	YGL007W	BRP1	hom	Dubious	0.311555793964466	0.377689067177823	no	1724	0.411691117533268	1333	NA	FF				Dubious ORF located in the upstream region of PMA1, deletion leads to polyamine resistance due to downregulation of PMA1	Unknown	Unknown	Unknown
YGL143C	YGL143C	MRF1	hom	Verified	0.310912479972987	0.37793357835809	no	1725	0.417897245236853	1371	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial translation release factor, involved in stop codon recognition and hydrolysis of the peptidyl-tRNA bond during mitochondrial translation; lack of MRF1 causes mitochondrial genome instability	translational termination|mitochondrial translational termination|mitochondrial translation	translation release factor activity	mitochondrion
YFR045W_p	YFR045W	YFR045W	hom	Uncharacterized	0.310858116195225	0.377954243218944	no	1726	0.354087484517864	1191	NA	FT		MITOCHONDRION		Putative mitochondrial transport protein; null mutant is viable, exhibits decreased levels of chitin and normal resistance to calcofluor white	transport	transporter activity	integral to membrane|mitochondrial inner membrane
YNL010W_p	YNL010W	YNL010W	hom	Uncharacterized	0.310483476959467	0.378096661278624	no	1727	0.403943938800106	1340	NA	FT		NUCLEUS		Putative protein of unknown function with similarity to phosphoserine phosphatases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; homozygous diploid mutant shows an increase in glycogen accumulation	biological_process	molecular_function	nucleus|cytoplasm
YBR026C	YBR026C	ETR1	hom	Verified	0.310021500770937	0.378272303045468	no	1728	0.406166960536949	1312	NA	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		2-enoyl thioester reductase, member of the medium chain dehydrogenase/reductase family; localized to in mitochondria, where it has a probable role in fatty acid synthesis	fatty acid biosynthetic process|aerobic respiration	enoyl-[acyl-carrier-protein] reductase activity	mitochondrion
YPR050C_d	YPR050C	YPR050C	hom	Dubious	0.309729832321721	0.37838320735004	no	1729	0.400272103503899	1331	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene MAK3/YPR051W	Unknown	Unknown	Unknown
YEL027W	YEL027W	VMA3	hom	Verified	0.308635831445485	0.378799280544855	no	1730	0.390371941719431	1292	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS|VACUOLAR TRANSPORT			Proteolipid subunit of the vacuolar H(+)-ATPase V0 sector (subunit c; dicyclohexylcarbodiimide binding subunit); required for vacuolar acidification and important for copper and iron metal ion homeostasis	cellular copper ion homeostasis|cellular iron ion homeostasis|endocytosis|vacuole organization|proton transport|vacuolar acidification|protein targeting to vacuole	hydrogen ion transmembrane transporter activity	vacuolar proton-transporting V-type ATPase, V0 domain|integral to membrane
YJL127C	YJL127C	SPT10	hom	Verified	0.308486754669188	0.378855988691519	no	1731	0.383931002618164	1255	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING	NUCLEUS		Putative histone acetylase with a role in transcriptional silencing, sequence-specific activator of histone genes, binds specifically and cooperatively to pairs of UAS elements in core histone promoters, functions at or near the TATA box	DNA repair|negative regulation of transcription from RNA polymerase II promoter|chromatin silencing at rDNA|chromatin remodeling|chromatin silencing at telomere|chromatin silencing at silent mating-type cassette	histone acetyltransferase activity|sequence-specific DNA binding	nucleus
YLL059C_d	YLL059C	YLL059C	hom	Dubious	0.308453949815314	0.378868467863039	no	1732	0.3900078521611	1296	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YJR116W_p	YJR116W	TDA4	hom	Uncharacterized	0.308287761828425	0.378931688752257	no	1733	0.341825765013178	1119	NA					Putative protein of unknown function; null mutant is sensitive to expression of the top1-T722A allele	biological_process	molecular_function	integral to membrane
YER178W	YER178W	PDA1	hom	Verified	0.307638318952333	0.379178779511489	no	1734	0.39260543428308	1318	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex, catalyzes the direct oxidative decarboxylation of pyruvate to acetyl-CoA; phosphorylated; regulated by glucose	acetyl-CoA biosynthetic process from pyruvate	pyruvate dehydrogenase (acetyl-transferring) activity	mitochondrial nucleoid|mitochondrion|mitochondrial pyruvate dehydrogenase complex
YDR409W	YDR409W	SIZ1	hom	Verified	0.305885791472354	0.379845802273199	no	1735	0.377005143833865	1230	NA	FT	CHROMOSOME SEGREGATION	NUCLEUS|SITE OF POLARIZED GROWTH|CHROMOSOME|CYTOSKELETON		SUMO/Smt3 ligase that promotes the attachment of sumo (Smt3p; small ubiquitin-related modifier) to proteins; binds Ubc9p and may bind septins; specifically required for sumoylation of septins in vivo; localized to the septin ring	protein sumoylation|chromosome segregation	SUMO ligase activity	nuclear chromatin|septin ring
YNR061C	YNR061C	YNR061C	hom	Verified	0.305723316453064	0.379907659412143	no	1736	0.367509284064285	1230	NA					Protein of unknown function; relocalizes from vacuole to cytoplasm upon DNA replication stress	biological_process	molecular_function	integral to membrane|fungal-type vacuole
YCR102W-A_d	YCR102W-A	YCR102W-A	hom	Dubious	0.305506587173338	0.379990176898892	no	1737	0.353485649347673	1167	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YOL096C	YOL096C	COQ3	hom	Verified	0.305387207100308	0.380035631991241	no	1738	0.379276616881891	1282	NA	FT	KETONE METABOLISM|COFACTOR METABOLISM	MITOCHONDRION		O-methyltransferase, catalyzes two different O-methylation steps in ubiquinone (Coenzyme Q) biosynthesis; component of a mitochondrial ubiquinone-synthesizing complex; phosphoprotein	ubiquinone biosynthetic process	hexaprenyldihydroxybenzoate methyltransferase activity	mitochondrion|mitochondrial inner membrane|extrinsic to membrane
YLR006C	YLR006C	SSK1	hom	Verified	0.30533065262281	0.380057166222181	no	1739	0.356818744985767	1183	NA	FT	SIGNALING|PROTEIN PHOSPHORYLATION			Cytoplasmic response regulator; part of a two-component signal transducer that mediates osmosensing via a phosphorelay mechanism; required for mitophagy; dephosphorylated form is degraded by the ubiquitin-proteasome system; potential Cdc28p substrate	activation of MAPKKK activity involved in osmosensory signaling pathway|positive regulation of protein autophosphorylation|osmosensory signaling pathway via two-component system	protein kinase activator activity|two-component response regulator activity|protein homodimerization activity|mitogen-activated protein kinase kinase kinase binding	cytoplasm
YLR122C_d	YLR122C	YLR122C	hom	Dubious	0.304747129149156	0.380279375975691	no	1740	0.391061063634133	1256	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR123C	Unknown	Unknown	Unknown
YGL166W	YGL166W	CUP2	hom	Verified	0.304519647740437	0.380366013170905	no	1741	0.388986324134569	1272	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Copper-binding transcription factor; activates transcription of the metallothionein genes CUP1-1 and CUP1-2 in response to elevated copper concentrations; CUP2 has a paralog, HAA1, that arose from the whole genome duplication	regulation of transcription from RNA polymerase II promoter|response to copper ion	RNA polymerase II core promoter proximal region sequence-specific DNA binding|copper ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity|copper ion binding	nucleus
YCR059C	YCR059C	YIH1	hom	Verified	0.304326695634865	0.380439504448876	no	1742	0.363591447606171	1232	NA	FT	TRANSLATION|PROTEIN PHOSPHORYLATION	NUCLEUS		Negative regulator of eIF2 kinase Gcn2p; competes with Gcn2p for binding to Gcn1p; may contribute to regulation of translation in response to starvation via regulation of Gcn2p; binds to monomeric actin and to ribosomes and polyribosomes; ortholog of mammalian IMPACT	negative regulation of protein phosphorylation	protein kinase inhibitor activity|ribosome binding|actin monomer binding	ribosome|nucleus|polysome|cytoplasm
YNL111C	YNL111C	CYB5	hom	Verified	0.304072582134788	0.380536297361229	no	1743	0.403568855205589	1350	NA	FF|FT	LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Cytochrome b5, involved in the sterol and lipid biosynthesis pathways; acts as an electron donor to support sterol C5-6 desaturation	sterol biosynthetic process	electron carrier activity	endoplasmic reticulum membrane
YBR241C_p	YBR241C	YBR241C	hom	Uncharacterized	0.303931109007453	0.380590188318284	no	1744	0.346249125947003	1134	NA					Putative transporter, member of the sugar porter family; green fluorescent protein (GFP)-fusion protein localizes to the vacuolar membrane; YBR241C is not an essential gene	transport|transmembrane transport	substrate-specific transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane|membrane
YMR101C	YMR101C	SRT1	hom	Verified	0.303562809244757	0.38073049456824	no	1745	0.366625444868617	1195	NA	FT	CARBOHYDRATE METABOLISM			Cis-prenyltransferase involved in synthesis of long-chain dolichols (19-22 isoprene units; as opposed to Rer2p which synthesizes shorter-chain dolichols); localizes to lipid bodies; transcription is induced during stationary phase	protein glycosylation	dehydrodolichyl diphosphate synthase activity|prenyltransferase activity	lipid particle
YJR126C	YJR126C	VPS70	hom	Verified	0.303422168690663	0.380784076664879	no	1746	0.371985134013943	1237	NA	FT	PROTEIN LOCALIZATION|PROTEOLYSIS|VACUOLAR TRANSPORT			Protein of unknown function involved in vacuolar protein sorting	protein targeting to vacuole	molecular_function	cellular_component
YNR020C	YNR020C	ATP23	hom	Verified	0.303370924964511	0.380803600380814	no	1747	0.390218310274695	1300	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Putative metalloprotease of the mitochondrial inner membrane, required for processing of Atp6p; has an additional role in assembly of the F0 sector of the F1F0 ATP synthase complex; substrate of the Mia40p-Erv1p disulfide relay system, and folding is assisted by Mia40p	protein processing|mitochondrial proton-transporting ATP synthase complex assembly	metalloendopeptidase activity	mitochondrial inner membrane|mitochondrial intermembrane space
YGR184C	YGR184C	UBR1	hom	Verified	0.303035913392793	0.380931246326182	no	1748	0.391323909230932	1294	NA	FT	PROTEOLYSIS			E3 ubiquitin ligase (N-recognin); forms heterodimer with Rad6p to ubiquitinate substrates in the N-end rule pathway; regulates peptide transport via Cup9p ubiquitination; plays a major role in targeting cytosolic misfolded proteins for degradation; mutation in human UBR1 causes Johansson-Blizzard Syndrome (JBS)	regulation of dipeptide transport|ubiquitin-dependent protein catabolic process via the N-end rule pathway|cytoplasm-associated proteasomal ubiquitin-dependent protein catabolic process|protein polyubiquitination	ubiquitin-protein ligase activity	proteasome regulatory particle, base subcomplex|cytoplasm
YGR066C_p	YGR066C	YGR066C	hom	Uncharacterized	0.302446448169691	0.381155875531565	no	1749	0.39922706685034	1303	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YNL116W	YNL116W	DMA2	hom	Verified	0.302199591984693	0.381249957629214	no	1750	0.418404985953319	1383	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION			Ubiquitin-protein ligase (E3); controls septin dynamics and the spindle position checkpoint (SPOC) along with functionally redundant ligase Dma1p by regulating the recruitment of Elm1p to the bud neck; regulates levels of the translation initiation factor eIF2 subunit Gcd11p, as well as abundance, localization, and ubiquitination of Cdk inhibitory kinase Swe1p; ortholog of human RNF8 protein, with sequence similarity to human Chfr; contains FHA and RING finger domains	establishment of mitotic spindle orientation|protein autoubiquitination|septin ring assembly|mitotic cell cycle spindle assembly checkpoint	ubiquitin-protein ligase activity	cytoplasm
YLR128W	YLR128W	DCN1	hom	Verified	0.301848210931584	0.381383888462822	no	1751	0.402101921661571	1318	NA					Scaffold-type E3 ligase required for cullin neddylation and ubiquitin ligase activation; contains a ubiquitin-binding domain (UBA) for ubiquitin and Nedd8 (Rub1p) interaction and a PONY domain involved in cullin binding and neddylation	protein neddylation|positive regulation of ubiquitin-protein ligase activity	ubiquitin binding|NEDD8 ligase activity|small conjugating protein binding	cellular_component
YNL109W_d	YNL109W	YNL109W	hom	Dubious	0.301001460509512	0.381706690408539	no	1752	0.387962645901008	1255	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YNL108C	Unknown	Unknown	Unknown
YBR213W	YBR213W	MET8	hom	Verified	0.300552993550101	0.381877690313157	no	1753	0.405197562638482	1341	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM			Bifunctional dehydrogenase and ferrochelatase, involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis	siroheme biosynthetic process|sulfate assimilation	precorrin-2 dehydrogenase activity|ferrochelatase activity	cellular_component
YDR198C	YDR198C	RKM2	hom	Verified	0.299658927814952	0.382218665239362	no	1754	0.399938622887377	1330	NA					Ribosomal protein lysine methyltransferase, responsible for trimethylation of the lysine residue at position 3 of Rpl12Ap and Rpl12Bp	peptidyl-lysine trimethylation|peptidyl-lysine monomethylation	protein-lysine N-methyltransferase activity	cellular_component
YCL021W-A_p	YCL021W-A	YCL021W-A	hom	Uncharacterized	0.299288607797294	0.382359923060191	no	1755	0.370866902346584	1232	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YEL056W	YEL056W	HAT2	hom	Verified	0.299150611419115	0.382412565504397	no	1756	0.367922892188443	1198	NA	FT	CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING	NUCLEUS	HISTONE ACETYLTRANSFERASE	Subunit of the Hat1p-Hat2p histone acetyltransferase complex; required for high affinity binding of the complex to free histone H4, thereby enhancing Hat1p activity; similar to human RbAp46 and 48; has a role in telomeric silencing	histone acetylation|chromatin assembly or disassembly|chromatin silencing at telomere	histone acetyltransferase activity|histone binding	histone acetyltransferase complex|nucleus|cytoplasm
YNR007C	YNR007C	ATG3	hom	Verified	0.298686017836171	0.382589813239515	no	1757	0.393673651678795	1306	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS			E2-like enzyme involved in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; plays a role in formation of Atg8p-phosphatidylethanolamine conjugates, which are involved in membrane dynamics during autophagy and Cvt; interaction with Atg8p is regulated by its acetylation by Esa1p (catalytic subunit of NuA4 histone acetyltransferase complex) while attenuation of Atg3 acetylation is mediated by histone deacetylase Rpd3p	C-terminal protein lipidation|piecemeal microautophagy of nucleus|mitochondrion degradation|CVT pathway|autophagic vacuole assembly	Atg8 ligase activity	cytosol|cytoplasm
YCR004C	YCR004C	YCP4	hom	Verified	0.298625968746609	0.382612724445898	no	1758	0.37381583509741	1223	NA	FT	OXIDATION-REDUCTION PROCESS	MITOCHONDRION		Protein of unknown function, has sequence and structural similarity to flavodoxins; predicted to be palmitoylated; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	electron carrier activity	mitochondrion|membrane raft|plasma membrane|cytoplasm
YOR082C_d	YOR082C	YOR082C	hom	Dubious	0.298530978018087	0.382648968168852	no	1759	0.382044659163328	1233	NA					Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene YOR083W	Unknown	Unknown	Unknown
YNL318C	YNL318C	HXT14	hom	Verified	0.298374646237864	0.382708618814382	no	1760	0.360396880087447	1181	NA	FT		MITOCHONDRION|PLASMA MEMBRANE		Protein with similarity to hexose transporter family members, expression is induced in low glucose and repressed in high glucose; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	hexose transport	galactose transmembrane transporter activity	mitochondrion|integral to membrane|plasma membrane
YMR271C	YMR271C	URA10	hom	Verified	0.298107476382002	0.382810567766561	no	1761	0.365033422425056	1212	NA	FT	NUCLEOTIDE METABOLISM			Minor orotate phosphoribosyltransferase (OPRTase) isozyme; catalyzes the fifth enzymatic step in the de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; URA10 has a paralog, URA5, that arose from the whole genome duplication	'de novo' pyrimidine nucleobase biosynthetic process|pyrimidine ribonucleoside biosynthetic process	orotate phosphoribosyltransferase activity	cytoplasm
YOR108W	YOR108W	LEU9	hom	Verified	0.298002686626337	0.382850556552624	no	1762	0.36730953617409	1243	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		Alpha-isopropylmalate synthase II (2-isopropylmalate synthase); catalyzes the first step in the leucine biosynthesis pathway; the minor isozyme, responsible for the residual alpha-IPMS activity detected in a leu4 null mutant; LEU9 has a paralog, LEU4, that arose from the whole genome duplication	leucine biosynthetic process	2-isopropylmalate synthase activity	mitochondrion
YPL257W_p	YPL257W	YPL257W	hom	Uncharacterized	0.297041343586472	0.383217472598331	no	1763	0.360034467381549	1186	NA	FT	CELL CYCLE			Putative protein of unknown function; homozygous diploid deletion strain exhibits low budding index; physically interacts with Hsp82p; YPL257W is not an essential gene	biological_process	molecular_function	integral to membrane
YDL178W	YDL178W	DLD2	hom	Verified	0.296802404108774	0.383308684961916	no	1764	0.415204232095284	1361	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS	MITOCHONDRION		D-lactate dehydrogenase, located in the mitochondrial matrix	lactate metabolic process	actin binding|D-lactate dehydrogenase (cytochrome) activity	mitochondrion|mitochondrial matrix
YMR316W	YMR316W	DIA1	hom	Verified	0.296578315090352	0.383394234213903	no	1765	0.398509100189585	1321	NA					Protein of unknown function, involved in invasive and pseudohyphal growth; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern	pseudohyphal growth|invasive growth in response to glucose limitation	molecular_function	cytoplasm
YOR366W_d	YOR366W	YOR366W	hom	Dubious	0.296157546049159	0.383554884292104	no	1766	0.392083245904901	1304	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR365C	Unknown	Unknown	Unknown
YPR015C_p	YPR015C	YPR015C	hom	Uncharacterized	0.296048222095019	0.383596627574518	no	1767	0.38624566466813	1261	NA					Putative protein of unknown function; overexpression causes a cell cycle delay or arrest	biological_process	sequence-specific DNA binding	cellular_component
YPR172W_p	YPR172W	YPR172W	hom	Uncharacterized	0.295666172972679	0.383742516407454	no	1768	0.38630042992785	1268	NA	FT	OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM	NUCLEUS		Putative pyridoxal 5'-phosphate synthase; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance; YPR172W has a paralog, YLR456W, that arose from the whole genome duplication	biological_process	molecular_function	nucleus|cytoplasm
YOL097W-A_p	YOL097W-A	YOL097W-A	hom	Uncharacterized	0.295554334291093	0.383785226115338	no	1769	0.387031534772256	1259	NA					Putative protein of unknown function; identified by expression profiling and mass spectrometry	biological_process	molecular_function	cellular_component
YGL043W	YGL043W	DST1	hom	Verified	0.29497266906041	0.384007379099734	no	1770	0.386499823678528	1264	NA	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|TRANSLATION	NUCLEUS		General transcription elongation factor TFIIS, enables RNA polymerase II to read through blocks to elongation by stimulating cleavage of nascent transcripts stalled at transcription arrest sites; maintains RNAPII elongation activity on ribosomal protein genes during conditions of transcriptional stress	transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|mRNA cleavage|maintenance of transcriptional fidelity during DNA-dependent transcription elongation from RNA polymerase II promoter|tRNA transcription from RNA polymerase III promoter|regulation of mRNA 3'-end processing|positive regulation of transcription elongation from RNA polymerase II promoter|transcription from RNA polymerase III promoter|transcription antitermination|positive regulation of RNA polymerase II transcriptional preinitiation complex assembly|transcription elongation from RNA polymerase II promoter	RNA polymerase II regulatory region DNA binding|RNA polymerase II core binding|core RNA polymerase II recruiting transcription factor activity	nucleus
YOR344C	YOR344C	TYE7	hom	Verified	0.294697916929793	0.384112327298877	no	1771	0.37965778603559	1262	NA	FT	CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS|CHROMOSOME		Serine-rich protein that contains a basic-helix-loop-helix (bHLH) DNA binding motif; binds E-boxes of glycolytic genes and contributes to their activation; may function as a transcriptional activator in Ty1-mediated gene expression	positive regulation of glycolysis|transcription, DNA-dependent	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	nuclear chromatin|nucleus
YHL034C	YHL034C	SBP1	hom	Verified	0.294578865186428	0.38415780462125	no	1772	0.371123629452459	1233	NA	FT	TRANSLATION	NUCLEUS		Protein that binds eIF4G and has a role in repression of translation; has an RGG motif; found in cytoplasmic P bodies; found associated with small nucleolar RNAs snR10 and snR11	negative regulation of translation|negative regulation of translation in response to stress	RNA binding|eukaryotic initiation factor 4G binding	nucleolus|cytoplasmic mRNA processing body|cytoplasm
YDR263C	YDR263C	DIN7	hom	Verified	0.294251456527037	0.384282881731961	no	1773	0.393462983501754	1303	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS|MITOCHONDRION		Mitochondrial nuclease functioning in DNA repair and replication, modulates the stability of the mitochondrial genome, induced by exposure to mutagens, also induced during meiosis at a time nearly coincident with commitment to recombination	DNA repair	nuclease activity	mitochondrion
YGR011W_d	YGR011W	YGR011W	hom	Dubious	0.294058748698601	0.384356505878711	no	1774	0.380007274815353	1228	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YJR011C_p	YJR011C	YJR011C	hom	Uncharacterized	0.294010900764813	0.3843747868585	no	1775	0.379242044312322	1244	NA					Putative protein of unknown function; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS	biological_process	molecular_function	cellular_component
YHL019C	YHL019C	APM2	hom	Verified	0.293919198036287	0.384409823901565	no	1776	0.38237810964468	1273	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Protein of unknown function, homologous to the medium chain of mammalian clathrin-associated protein complex; involved in vesicular transport	Golgi to vacuole transport|vesicle-mediated transport	clathrin binding	AP-1 adaptor complex
YLR315W	YLR315W	NKP2	hom	Verified	0.292727751368051	0.384865128033586	no	1777	0.427433059717694	1424	NA	FT	CELL CYCLE|CELL DIVISION	NUCLEUS|CHROMOSOME|CYTOSKELETON	KINETOCHORE	Central kinetochore protein and subunit of the Ctf19 complex; mutants have elevated rates of chromosome loss; orthologous to fission yeast kinetochore protein cnl2	biological_process	molecular_function	spindle pole body|kinetochore
YGL259W_p	YGL259W	YPS5	hom	Uncharacterized	0.29270207737685	0.38487494094412	no	1778	0.377646058179649	1252	NA	FT	PROTEOLYSIS			Protein with similarity to GPI-anchored aspartic proteases such as Yap1p and Yap3p	biological_process	aspartic-type endopeptidase activity	cellular_component
YKR105C_p	YKR105C	VBA5	hom	Uncharacterized	0.292370879328581	0.385001535460802	no	1779	0.379171217227303	1261	NA					Plasma membrane protein of the Major Facilitator Superfamily (MFS); involved in amino acid uptake and drug sensitivity; similar to Vba3p	biological_process	molecular_function	integral to membrane
YER040W	YER040W	GLN3	hom	Verified	0.291176781134696	0.385458059773913	no	1780	0.373032719842128	1257	NA	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Transcriptional activator of genes regulated by nitrogen catabolite repression (NCR), localization and activity regulated by quality of nitrogen source	nitrogen catabolite activation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	cytosol|nucleus
YJL205C	YJL205C	NCE101	hom	Verified	0.290458607259924	0.385732706512973	no	1781	0.361514238273396	1233	NA	FT	PROTEIN LOCALIZATION			Protein of unknown function, involved in secretion of proteins that lack classical secretory signal sequences	protein secretion	molecular_function	cellular_component
YKL091C	YKL091C	YKL091C	hom	Verified	0.290246575930027	0.385813803288219	no	1782	0.390654321287385	1299	NA	FT		NUCLEUS		Putative homolog of Sec14p, which is a phosphatidylinositol/phosphatidylcholine transfer protein involved in lipid metabolism; localizes to the nucleus; contains a CRAL/TRIO domain and binds several lipids in a large-scale study	biological_process	phosphatidylcholine binding|phosphatidylinositol transporter activity|phosphatidylinositol binding|phosphatidylcholine transporter activity	nucleus
YDR092W	YDR092W	UBC13	hom	Verified	0.289905904627669	0.385944112143103	no	1783	0.389748420719275	1284	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RESPONSE TO DNA DAMAGE	NUCLEUS		Ubiquitin-conjugating enzyme involved in the error-free DNA postreplication repair pathway; interacts with Mms2p to assemble ubiquitin chains at the Ub Lys-63 residue; DNA damage triggers redistribution from the cytoplasm to the nucleus	postreplication repair|protein monoubiquitination|protein polyubiquitination|free ubiquitin chain polymerization	ubiquitin-protein ligase activity	ubiquitin conjugating enzyme complex|nucleus|cytoplasm
YOR012W_p	YOR012W	YOR012W	hom	Uncharacterized	0.288515887315872	0.386475935502195	no	1784	0.348119745002677	1161	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YBR015C	YBR015C	MNN2	hom	Verified	0.288122512513715	0.386626480244763	no	1785	0.473125390681217	1583	NA	FF|FT	CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Alpha-1,2-mannosyltransferase, responsible for addition of the first alpha-1,2-linked mannose to form the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment	protein glycosylation	alpha-1,2-mannosyltransferase activity	Golgi apparatus
YJL179W	YJL179W	PFD1	hom	Verified	0.288020479462476	0.386665531134693	no	1786	0.391039742010878	1288	NA	FT	CYTOSKELETON ORGANIZATION			Subunit of heterohexameric prefoldin, which binds cytosolic chaperonin and transfers target proteins to it; involved in the biogenesis of actin and of alpha- and gamma-tubulin	protein folding|cytoskeleton organization	unfolded protein binding	prefoldin complex
YGR283C	YGR283C	YGR283C	hom	Verified	0.286453250924415	0.387265497106879	no	1787	0.384352110212876	1282	NA	FT		NUCLEUS		Putative S-adenosylmethionine-dependent methyltransferase; may interact with ribosomes, based on co-purification experiments; predicted to be involved in ribosome biogenesis; null mutant is resistant to fluconazole; GFP-fusion protein localizes to the nucleolus	biological_process	S-adenosylmethionine-dependent methyltransferase activity	ribosome|nucleolus
YPL031C	YPL031C	PHO85	hom	Verified	0.285933962932171	0.387464350273018	no	1788	0.424847156347177	1408	NA	FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|CELL CYCLE|SIGNALING|RESPONSE TO DNA DAMAGE|CELL WALL ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS|GEN. OF PRECURSOR METABOLITES A	NUCLEUS		Cyclin-dependent kinase, with ten cyclin partners; involved in regulating the cellular response to nutrient levels and environmental conditions and progression through the cell cycle	regulation of transcription involved in G1/S phase of mitotic cell cycle|negative regulation of calcium-mediated signaling|regulation of protein stability|regulation of protein localization|protein phosphorylation|response to DNA damage stimulus|negative regulation of phosphate metabolic process|fungal-type cell wall organization|regulation of establishment or maintenance of cell polarity|negative regulation of glycogen biosynthetic process|negative regulation of transcription from RNA polymerase II promoter|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of macroautophagy|negative regulation of macroautophagy	protein kinase activity|cyclin-dependent protein kinase activity	cyclin-dependent protein kinase holoenzyme complex|nucleus
YOR026W	YOR026W	BUB3	hom	Verified	0.285758781936099	0.387531439742501	no	1789	0.386550591186616	1289	NA	FT	CELL CYCLE	NUCLEUS|CHROMOSOME	KINETOCHORE	Kinetochore checkpoint WD40 repeat protein that localizes to kinetochores during prophase and metaphase, delays anaphase in the presence of unattached kinetochores; forms complexes with Mad1p-Bub1p and with Cdc20p, binds Mad2p and Mad3p	mitotic cell cycle G2/M transition decatenation checkpoint|mitotic cell cycle spindle assembly checkpoint	ubiquitin binding	mitotic checkpoint complex|condensed nuclear chromosome kinetochore
YGR223C	YGR223C	HSV2	hom	Verified	0.285460838658176	0.387645551478348	no	1790	0.390223224163662	1269	NA	FT	MEMBRANE ORGANIZATION|RESPONSE TO NUTRIENT LEVELS			Phosphatidylinositol 3,5-bisphosphate-binding protein, plays a role in micronucleophagy; belongs to the PROPPIN family of proteins; predicted to fold as a seven-bladed beta-propeller; displays punctate cytoplasmic localization	piecemeal microautophagy of nucleus	phosphatidylinositol binding	endosome|fungal-type vacuole|extrinsic to membrane|cytoplasm
YLL006W	YLL006W	MMM1	hom	Verified	0.285264978304102	0.387720570927102	no	1791	0.410818234719388	1343	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION		ER integral membrane protein, component of the ERMES complex that links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth	mitochondrion organization|mitochondrial genome maintenance|protein import into mitochondrial outer membrane|phospholipid transport	molecular_function	mitochondrial outer membrane|mitochondrion|integral to endoplasmic reticulum membrane|ERMES complex
YPL127C	YPL127C	HHO1	hom	Verified	0.285078657359734	0.387791940432062	no	1792	0.384177149340492	1280	NA	FT	CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS|CHROMOSOME		Histone H1, linker histone with roles in meiosis and sporulation; decreasing levels early in sporulation may promote meiosis, and increasing levels during sporulation facilitate compaction of spore chromatin; binds to promoters and within genes in mature spores; may be recruited by Ume6p to promoter regions, contributing to transcriptional repression outside of meiosis; suppresses DNA repair involving homologous recombination	negative regulation of DNA recombination|negative regulation of chromatin silencing|regulation of transcription, DNA-dependent	DNA binding	nucleus|nuclear nucleosome
YAL056C-A_d	YAL056C-A	YAL056C-A	hom	Dubious	0.284692739540057	0.387939776790367	no	1793	0.406307879850842	1347	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YHR037W	YHR037W	PUT2	hom	Verified	0.284451053081146	0.388032369660681	no	1794	0.39951659848089	1314	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS	MITOCHONDRION		Delta-1-pyrroline-5-carboxylate dehydrogenase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; deficiency of the human homolog causes HPII, an autosomal recessive inborn error of metabolism	glutamate biosynthetic process|proline catabolic process to glutamate	1-pyrroline-5-carboxylate dehydrogenase activity	mitochondrion|mitochondrial matrix
YPR111W	YPR111W	DBF20	hom	Verified	0.283407347811219	0.388432298228105	no	1795	0.370107200285755	1231	NA	FT	CELL CYCLE|CELL DIVISION|PROTEIN PHOSPHORYLATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Ser/Thr kinase involved in late nuclear division, one of the mitotic exit network (MEN) proteins; necessary for the execution of cytokinesis; also plays a role in regulating the stability of SWI5 and CLB2 mRNAs	cytokinesis after mitosis|protein phosphorylation|barrier septum assembly involved in cell cycle cytokinesis|regulation of mRNA catabolic process|exit from mitosis	protein serine/threonine kinase activity	spindle pole body|cellular bud neck|cytoplasm
YNL321W	YNL321W	VNX1	hom	Verified	0.281537303477009	0.389149160292321	no	1796	0.394691096974619	1286	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Calcium/H+ antiporter localized to the endoplasmic reticulum membrane; member of the calcium exchanger (CAX) family; potential Cdc28p substrate	potassium ion transport|sodium ion transport|hydrogen transport	potassium:hydrogen antiporter activity|sodium:hydrogen antiporter activity|calcium:hydrogen antiporter activity	fungal-type vacuole membrane|integral to membrane|endoplasmic reticulum membrane|fungal-type vacuole
YML003W_p	YML003W	YML003W	hom	Uncharacterized	0.28048052750599	0.389554431476705	no	1797	0.375940180279586	1254	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YOR265W	YOR265W	RBL2	hom	Verified	0.27855376741202	0.3902936485151	no	1798	0.40404659768707	1345	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION	CYTOSKELETON		Protein involved in microtubule morphogenesis; required for protection from excess free beta-tubulin; proposed to be involved the folding of beta-tubulin; similar to mouse beta-tubulin cofactor A; protein abundance increases in response to DNA replication stress	tubulin complex assembly|tubulin complex biogenesis	tubulin binding|beta-tubulin binding	cytoplasm
YGL031C	YGL031C	RPL24A	hom	Verified	0.277661713284367	0.390636026823473	no	1799	0.397997604735699	1322	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L24A; not essential for translation but may be required for normal translation rate; homologous to mammalian ribosomal protein L24, no bacterial homolog; RPL24A has a paralog, RPL24B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome|RNA binding	cytosolic large ribosomal subunit
YHR171W	YHR171W	ATG7	hom	Verified	0.277181966607304	0.390820192952935	no	1800	0.428731141050526	1400	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS	MITOCHONDRION		Autophagy-related protein and dual specificity member of the E1 family of ubiquitin-activating enzymes; mediates the conjugation of Atg12p with Atg5p and Atg8p with phosphatidylethanolamine, required steps in autophagosome formation	C-terminal protein lipidation|protein modification by small protein conjugation|piecemeal microautophagy of nucleus|mitochondrion degradation|macroautophagy|CVT pathway	APG8 activating enzyme activity|APG12 activating enzyme activity	cytosol|mitochondrion|membrane|pre-autophagosomal structure
YJL028W	YJL028W	YJL028W	hom	Verified	0.276770999948025	0.390977975147153	no	1801	0.354821098346738	1178	NA					Protein of unknown function; may interact with ribosomes, based on co-purification experiments	biological_process	molecular_function	ribosome
YKL071W_p	YKL071W	YKL071W	hom	Uncharacterized	0.276521610927589	0.391073731682844	no	1802	0.394042072623672	1306	NA	FT	OXIDATION-REDUCTION PROCESS			Putative protein of unknown function; expression induced in cells treated with the mycotoxin patulin, and also the quinone methide triterpene celastrol; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	biological_process	molecular_function	integral to membrane|cytoplasm
YER130C_p	YER130C	YER130C	hom	Uncharacterized	0.276275680459917	0.391168166724007	no	1803	0.433960777393379	1433	NA	FT		NUCLEUS		Protein of unknown function; transcription is regulated by Haa1p, Sok2p and Zap1p transcriptional activators; computational analysis suggests a role as a transcription factor; C. albicans homolog (MNL1) plays a role in adaptation to stress	biological_process	sequence-specific DNA binding	cellular_component
YAL068C	YAL068C	PAU8	hom	Verified	0.276107195756937	0.39123286700682	no	1804	0.380396335727422	1278	NA	FT	TRANSCRIPTION FROM RNA POL II			Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions	ascospore formation|positive regulation of transcription from RNA polymerase II promoter	molecular_function	cellular_component
YIL146C	YIL146C	ATG32	hom	Verified	0.275903455234212	0.391311109996148	no	1805	0.367322662315771	1221	NA	FT	CELL WALL ORG/BIOGENESIS	MITOCHONDRION		Mitochondrial outer membrane protein required to initiate mitophagy; recruits the autophagy adaptor protein Atg11p and the ubiquitin-like protein Atg8p to the mitochondrial surface to initiate mitophagy, the selective vacuolar degradation of mitochondria in response to starvation; can promote pexophagy when placed ectopically in the peroxisomal membrane	fungal-type cell wall organization|mitochondrion degradation	molecular_function	integral to mitochondrial outer membrane
YHR178W	YHR178W	STB5	hom	Verified	0.275869885319079	0.391324002357881	no	1806	0.381081544510406	1261	NA	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		Transcription factor, involved in regulating multidrug resistance and oxidative stress response; forms a heterodimer with Pdr1p; contains a Zn(II)2Cys6 zinc finger domain that interacts with a pleiotropic drug resistance element in vitro	response to xenobiotic stimulus|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|transcription, DNA-dependent	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	nucleus
YKL146W	YKL146W	AVT3	hom	Verified	0.274877375482305	0.391705224796942	no	1807	0.390548519554214	1293	NA	FT	VACUOLAR TRANSPORT			Vacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters	amino acid export from vacuole	transporter activity|L-glutamine transmembrane transporter activity|L-isoleucine transmembrane transporter activity|L-tyrosine transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane
YLR428C_d	YLR428C	YLR428C	hom	Dubious	0.274095518721985	0.392005608777444	no	1808	0.401049308302947	1334	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CRN1	Unknown	Unknown	Unknown
YDR446W	YDR446W	ECM11	hom	Verified	0.273099268147673	0.392388454642957	no	1809	0.368095110681228	1208	NA	FT	CELL CYCLE|CELL WALL ORG/BIOGENESIS	NUCLEUS		Non-essential protein apparently involved in meiosis, GFP fusion protein is present in discrete clusters in the nucleus throughout mitosis; may be involved in maintaining chromatin structure	fungal-type cell wall organization|reciprocal meiotic recombination	molecular_function	nucleus
YJR043C	YJR043C	POL32	hom	Verified	0.273080428256948	0.392395695567541	no	1810	0.404560567040653	1322	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Third subunit of DNA polymerase delta, involved in chromosomal DNA replication; required for error-prone DNA synthesis in the presence of DNA damage and processivity; interacts with Hys2p, PCNA (Pol30p), and Pol1p	RNA-dependent DNA replication|lagging strand elongation|postreplication repair|base-excision repair|DNA replication, removal of RNA primer|nucleotide-excision repair|mismatch repair|double-strand break repair via break-induced replication|leading strand elongation	DNA-directed DNA polymerase activity|single-stranded DNA specific 3'-5' exodeoxyribonuclease activity	delta DNA polymerase complex|nucleus
YPL212C	YPL212C	PUS1	hom	Verified	0.271951801943955	0.392829539740502	no	1811	0.376882009295237	1249	NA	FT	RNA PROCESSING	NUCLEUS		tRNA:pseudouridine synthase, introduces pseudouridines at positions 26-28, 34-36, 65, and 67 of tRNA; nuclear protein that appears to be involved in tRNA export; also acts on U2 snRNA	snRNA pseudouridine synthesis|tRNA pseudouridine synthesis	pseudouridine synthase activity	nucleus
YER188W_d	YER188W	YER188W	hom	Dubious	0.271945020388912	0.39283214697461	no	1812	0.449576828466734	1466	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; large-scale analyses show mRNA expression increases under anaerobic conditions and two-hybrid interactions with Sst2p	Unknown	Unknown	Unknown
YIL015W	YIL015W	BAR1	hom	Verified	0.271648062985674	0.392946319820075	no	1813	0.390709123547553	1294	NA	FT	SIGNALING|PROTEOLYSIS			Aspartyl protease secreted into the periplasmic space of mating type a cells, helps cells find mating partners, cleaves and inactivates alpha factor allowing cells to recover from alpha-factor-induced cell cycle arrest	adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion|peptide catabolic process	aspartic-type endopeptidase activity	cell wall-bounded periplasmic space
YJL047C	YJL047C	RTT101	hom	Verified	0.27040580497202	0.393424037337049	no	1814	0.407635447324221	1342	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|PROTEOLYSIS	NUCLEUS	UBIQUITIN LIGASE COMPLEX	Cullin subunit of a Roc1p-dependent E3 ubiquitin ligase complex with a role in anaphase progression; implicated in Mms22-dependent DNA repair; involved with Mms1p in nonfunctional rRNA decay; modified by the ubiquitin-like protein, Rub1p	replication fork processing|negative regulation of transposition, RNA-mediated|regulation of mitosis|nonfunctional rRNA decay|ubiquitin-dependent protein catabolic process	ubiquitin-protein ligase activity	Cul8-RING ubiquitin ligase complex|nucleus|cytoplasm
YDR295C	YDR295C	HDA2	hom	Verified	0.270348400656804	0.393446116383984	no	1815	0.375702101693734	1252	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS|CHROMOSOME		Subunit of a possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex containing an Hda1p homodimer and an Hda2p-Hda3p heterodimer; involved in telomere maintenance	negative regulation of transcription from RNA polymerase II promoter|gene silencing by RNA|histone deacetylation|gene silencing involved in chronological cell aging	histone deacetylase activity|chromatin binding|DNA binding	nucleus|HDA1 complex
YBR233W	YBR233W	PBP2	hom	Verified	0.269649662453451	0.393714894946048	no	1816	0.405547190475495	1327	NA	FT		NUCLEUS		RNA binding protein; has similarity to mammalian heterogeneous nuclear RNP K protein, involved in the regulation of telomere position effect and telomere length; relative distribution to the nucleus increases upon DNA replication stress	telomere maintenance via telomere shortening	mRNA binding	cytoplasm
YAL061W_p	YAL061W	BDH2	hom	Uncharacterized	0.268590995089356	0.394122221309647	no	1817	0.360746712754409	1210	NA	FT	OXIDATION-REDUCTION PROCESS	NUCLEUS		Putative medium-chain alcohol dehydrogenase with similarity to BDH1; transcription induced by constitutively active PDR1 and PDR3	biological_process	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	nucleus|cytoplasm
YOR162C	YOR162C	YRR1	hom	Verified	0.268496207921869	0.394158696695377	no	1818	0.443661035152649	1476	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		Zn2-Cys6 zinc-finger transcription factor; activates genes involved in multidrug resistance; paralog of Yrm1p, acting on an overlapping set of target genes; YRR1 has a paralog, PDR8, that arose from the whole genome duplication	regulation of transcription from RNA polymerase II promoter in response to oxidative stress|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity	nucleus
YDL062W_d	YDL062W	YDL062W	hom	Dubious	0.268472600737062	0.3941677812042	no	1819	0.400203745769487	1337	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized ORF YDL063C; YDL062W is not essential	Unknown	Unknown	Unknown
YMR222C	YMR222C	FSH2	hom	Verified	0.268409450851629	0.394192082804619	no	1820	0.39526080120543	1304	NA					Putative serine hydrolase that localizes to the cytoplasm; sequence is similar to S. cerevisiae Fsh1p and Fsh3p and the human candidate tumor suppressor OVCA2	biological_process	molecular_function	cytoplasm
YNL279W	YNL279W	PRM1	hom	Verified	0.268385666734238	0.394201235613955	no	1821	0.399901753143803	1307	NA	FT	MEMBRANE ORGANIZATION	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Pheromone-regulated multispanning membrane protein involved in membrane fusion during mating; predicted to have 5 transmembrane segments and a coiled coil domain; localizes to the shmoo tip; regulated by Ste12p	plasma membrane fusion involved in cytogamy|response to pheromone	molecular_function	integral to membrane|mating projection tip
YMR001C-A_p	YMR001C-A	YMR001C-A	hom	Uncharacterized	0.267731312078601	0.39445307291916	no	1822	0.389177499429269	1269	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YOR200W_d	YOR200W	YOR200W	hom	Dubious	0.267695424266959	0.394466886109705	no	1823	0.419944793188362	1404	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MRM1/YOR201c	Unknown	Unknown	Unknown
YNL180C	YNL180C	RHO5	hom	Verified	0.267060626794322	0.394711241077516	no	1824	0.388171871141651	1235	NA	FT	SIGNALING	NUCLEUS|PLASMA MEMBRANE		Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely involved in protein kinase C (Pkc1p)-dependent signal transduction pathway that controls cell integrity	Rho protein signal transduction	GTPase activity	endomembrane system|fungal-type vacuole membrane|plasma membrane|nucleus|cytoplasm
YCL001W-A_p	YCL001W-A	YCL001W-A	hom	Uncharacterized	0.266537757285554	0.394912542314879	no	1825	0.404127125924023	1347	NA					Putative protein of unknown function; YCL001W-A gene has similarity to DOM34 and is present in a region duplicated between chromosomes XIV and III	biological_process	molecular_function	cellular_component
YFR041C	YFR041C	ERJ5	hom	Verified	0.266201327585434	0.395042080319253	no	1826	0.379011537990146	1230	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Type I membrane protein with a J domain is required to preserve the folding capacity of the endoplasmic reticulum; loss of the non-essential ERJ5 gene leads to a constitutively induced unfolded protein response	protein folding	molecular_function	endoplasmic reticulum
YBR039W	YBR039W	ATP3	hom	Verified	0.265953904265459	0.395137354946208	no	1827	0.411945094788437	1359	NA	FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS	MITOCHONDRION		Gamma subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis	ATP synthesis coupled proton transport	proton-transporting ATPase activity, rotational mechanism	mitochondrion|integral to membrane|mitochondrial proton-transporting ATP synthase, central stalk
YJL044C	YJL044C	GYP6	hom	Verified	0.265826145150827	0.395186553256906	no	1828	0.390629726352331	1319	NA	FT	PROTEIN LOCALIZATION|SIGNALING|NUCLEOTIDE METABOLISM			GTPase-activating protein (GAP) for the yeast Rab family member, Ypt6p; involved in vesicle mediated protein transport	intracellular protein transport	GTPase activator activity	endosome|clathrin-coated vesicle
YGR040W	YGR040W	KSS1	hom	Verified	0.264886504458635	0.395548447492722	no	1829	0.409173918560105	1376	NA	FT	CELL CYCLE|SIGNALING|PROTEIN PHOSPHORYLATION	NUCLEUS		Mitogen-activated protein kinase (MAPK) involved in signal transduction pathways that control filamentous growth and pheromone response; the KSS1 gene is nonfunctional in S288C strains and functional in W303 strains	pheromone-dependent signal transduction involved in conjugation with cellular fusion|signal transduction involved in filamentous growth|negative regulation of sequence-specific DNA binding transcription factor activity|protein phosphorylation|invasive growth in response to glucose limitation	MAP kinase activity|protein kinase activity|transcription factor binding	nucleus
YLR385C	YLR385C	SWC7	hom	Verified	0.26432583648203	0.395764426697775	no	1830	0.387432942887052	1288	NA	FT	CHROMATIN ORGANIZATION	NUCLEUS|CHROMOSOME		Protein of unknown function, component of the Swr1p complex that incorporates Htz1p into chromatin	chromatin remodeling	molecular_function	Swr1 complex|nucleus
YJL077C	YJL077C	ICS3	hom	Verified	0.264070500446462	0.395862797259746	no	1831	0.40039029274098	1347	NA					Protein of unknown function; may play a role in vacuolar sorting, null mutants are hypersensitive to sortin2	biological_process	molecular_function	cellular_component
YJR018W_d	YJR018W	YJR018W	hom	Dubious	0.264023438978956	0.395880928848137	no	1832	0.380546728048148	1269	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YCR047C	YCR047C	BUD23	hom	Verified	0.26356804279231	0.396056393067222	no	1833	0.374734721165093	1264	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|RIBOSOME BIOGENESIS|CELL DIVISION	NUCLEUS		Methyltransferase, methylates residue G1575 of 18S rRNA; required for rRNA processing and nuclear export of 40S ribosomal subunits independently of methylation activity; diploid mutant displays random budding pattern	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|rRNA (guanine-N7)-methylation|cellular bud site selection|ribosomal small subunit export from nucleus	S-adenosylmethionine-dependent methyltransferase activity|rRNA (guanine) methyltransferase activity	nucleolus|nucleus|cytoplasm
YIR036C_p	YIR036C	IRC24	hom	Uncharacterized	0.262989679763078	0.396279266785251	no	1834	0.397760053771894	1305	NA	FT	OXIDATION-REDUCTION PROCESS			Putative benzil reductase;(GFP)-fusion protein localizes to the cytoplasm and is induced by the DNA-damaging agent MMS; sequence similarity with short-chain dehydrogenase/reductases; null mutant has increased spontaneous Rad52p foci	biological_process	molecular_function	integral to membrane|cytoplasm
YJL201W	YJL201W	ECM25	hom	Verified	0.262792386882135	0.396355301875503	no	1835	0.423913565094695	1406	NA	FT	SIGNALING|CELL WALL ORG/BIOGENESIS			Non-essential protein of unknown function; promoter contains a consensus binding sequence for factor Abf1p	fungal-type cell wall organization|filamentous growth	molecular_function	cytoplasm
YIR027C	YIR027C	DAL1	hom	Verified	0.262739923001822	0.396375521696876	no	1836	0.405261593905652	1337	NA					Allantoinase, converts allantoin to allantoate in the first step of allantoin degradation; expression sensitive to nitrogen catabolite repression	allantoin assimilation pathway	allantoinase activity	cellular_component
YNR071C_p	YNR071C	YNR071C	hom	Uncharacterized	0.262130413187888	0.396610450004594	no	1837	0.397319576718328	1317	NA	FT	CARBOHYDRATE METABOLISM			Putative aldose 1-epimerase	biological_process	molecular_function	cellular_component
YPL234C	YPL234C	VMA11	hom	Verified	0.261464577758892	0.396867131249183	no	1838	0.407744191227731	1346	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Vacuolar ATPase V0 domain subunit c', involved in proton transport activity; hydrophobic integral membrane protein (proteolipid) containing four transmembrane segments; N and C termini are in the vacuolar lumen	vacuolar acidification	proton-transporting ATPase activity, rotational mechanism	vacuolar proton-transporting V-type ATPase, V0 domain|integral to membrane|fungal-type vacuole
YBR138C_p	YBR138C	YBR138C	hom	Uncharacterized	0.261177436107458	0.396977838881387	no	1839	0.35170976911321	1175	NA					Cytoplasmic protein of unknown function, potentially phosphorylated by Cdc28p; YBR138C is not an essential gene	biological_process	molecular_function	cytoplasm
YDL036C	YDL036C	PUS9	hom	Verified	0.261122836824899	0.396998890606555	no	1840	0.385298054440727	1255	NA	FT	RNA PROCESSING	NUCLEUS|MITOCHONDRION		Mitochondrial tRNA:pseudouridine synthase, catalyzes the formation of pseudouridine at position 32 in mitochondrial tRNAs; contains an N-terminal mitochondrial targeting sequence	tRNA pseudouridine synthesis	pseudouridine synthase activity	mitochondrion|nucleus|cytoplasm
YHR146W	YHR146W	CRP1	hom	Verified	0.260545776684539	0.397221404752428	no	1841	0.415536217701823	1386	NA	FT		NUCLEUS		Protein that binds to cruciform DNA structures	biological_process	DNA binding	nucleus
YBR200W	YBR200W	BEM1	hom	Verified	0.25878806476115	0.397899383600961	no	1842	0.377044079941399	1285	NA	FT		SITE OF POLARIZED GROWTH|CYTOSKELETON		Protein containing SH3-domains, involved in establishing cell polarity and morphogenesis; functions as a scaffold protein for complexes that include Cdc24p, Ste5p, Ste20p, and Rsr1p	establishment of cell polarity|cell morphogenesis involved in conjugation with cellular fusion	protein complex scaffold|phosphatidylinositol-3-phosphate binding	incipient cellular bud site|mating projection tip|cellular bud neck|cellular bud tip
YKR020W	YKR020W	VPS51	hom	Verified	0.257935640071018	0.398228289234141	no	1843	0.413225991604749	1365	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL DIVISION|VACUOLAR TRANSPORT	GOLGI APPARATUS		Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; links the (VFT/GARP) complex to the SNARE Tlg1p	vesicle organization|retrograde transport, endosome to Golgi|budding cell apical bud growth|regulation of cell size|protein targeting to vacuole	protein binding	Golgi apparatus|GARP complex
YNR070W_p	YNR070W	PDR18	hom	Uncharacterized	0.257255511898947	0.398490766632586	no	1844	0.377325243970948	1270	NA	FT	NUCLEOTIDE METABOLISM	MITOCHONDRION		Putative transporter of the ATP-binding cassette (ABC) family, implicated in pleiotropic drug resistance; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	transport	ATPase activity, coupled to transmembrane movement of substances	mitochondrion|integral to membrane|membrane
YML115C	YML115C	VAN1	hom	Verified	0.257010264422309	0.39858542465311	no	1845	0.44691485753063	1459	NA	FT	CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Component of the mannan polymerase I, which contains Van1p and Mnn9p and is involved in the first steps of mannan synthesis; mutants are vanadate-resistant	protein N-linked glycosylation	alpha-1,6-mannosyltransferase activity	alpha-1,6-mannosyltransferase complex
YCR100C_p	YCR100C	YCR100C	hom	Uncharacterized	0.256191518137491	0.398901478841557	no	1846	0.418459993463142	1364	NA					Putative protein of unknown function	biological_process	molecular_function	integral to membrane
YOL152W	YOL152W	FRE7	hom	Verified	0.256070643849994	0.398948144613454	no	1847	0.403565806677065	1352	NA	FT	ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|GEN. OF PRECURSOR METABOLITES AND ENERGY	PLASMA MEMBRANE		Putative ferric reductase with similarity to Fre2p; expression induced by low copper levels	iron ion transport|copper ion import	ferric-chelate reductase activity	integral to membrane|plasma membrane
YHL026C_p	YHL026C	YHL026C	hom	Uncharacterized	0.255381217885057	0.399214337953993	no	1848	0.407746820423211	1334	NA					Putative protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; YHL026C is not an essential gene; in 2005 the start site was moved 141 nt upstream (see Locus History)	biological_process	molecular_function	cellular_component
YJL136C	YJL136C	RPS21B	hom	Verified	0.255340353866918	0.399230117378185	no	1849	0.409548474401478	1350	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21B has a paralog, RPS21A, that arose from the whole genome duplication	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|cytoplasmic translation|endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome	cytosolic small ribosomal subunit
YKR096W	YKR096W	ESL2	hom	Verified	0.255310722108793	0.399241559627641	no	1850	0.401103654517306	1318	NA	FT		NUCLEUS		Protein of unknown function that interacts with Pex14p; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; predicted to contain a PINc domain	biological_process	molecular_function	ribosome|nucleus|cytoplasm
YER167W	YER167W	BCK2	hom	Verified	0.255218702524586	0.399277093374334	no	1851	0.427203976287195	1410	NA	FT	CELL CYCLE	NUCLEUS		Protein rich in serine and threonine residues involved in protein kinase C signaling pathway, which controls cell integrity; overproduction suppresses pkc1 mutations	regulation of cell cycle|positive regulation of gene expression|G1/S transition of mitotic cell cycle	molecular_function	nucleus|cytoplasm
YCL022C_d	YCL022C	YCL022C	hom	Dubious	0.255005618174511	0.399359379989099	no	1852	0.365021927916153	1205	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene KCC4/YCL024W	Unknown	Unknown	Unknown
YNR029C_p	YNR029C	YNR029C	hom	Uncharacterized	0.254690641968031	0.399481022290113	no	1853	0.381278961503594	1283	NA					Putative protein of unknown function, deletion confers reduced fitness in saline	biological_process	molecular_function	cytoplasm
YDR315C	YDR315C	IPK1	hom	Verified	0.254383914341608	0.399599488407868	no	1854	0.436751326344018	1444	NA	FT		NUCLEUS		Inositol 1,3,4,5,6-pentakisphosphate 2-kinase, nuclear protein required for synthesis of 1,2,3,4,5,6-hexakisphosphate (phytate), which is integral to cell function; has 2 motifs conserved in other fungi; ipk1 gle1 double mutant is inviable	nuclear-transcribed mRNA catabolic process, non-stop decay|inositol phosphate biosynthetic process	inositol pentakisphosphate 2-kinase activity	nucleus
YNL094W	YNL094W	APP1	hom	Verified	0.253866684548279	0.399799276821108	no	1855	0.429217448311794	1422	NA	FT	CYTOSKELETON ORGANIZATION	CYTOSKELETON		Phosphatidate phosphatase, converts phosphatidate to diacylglycerol; App1p, Pah1p, Dpp1p, and Lpp1p are responsible for all the phosphatidate phosphatase activity; component of cortical actin patches; interacts with components of endocytic pathway	actin cytoskeleton organization	molecular_function	actin cytoskeleton|actin cortical patch
YDR337W	YDR337W	MRPS28	hom	Verified	0.253152737361578	0.40007509361403	no	1856	0.411942404237906	1363	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the small subunit	mitochondrial translation	structural constituent of ribosome|RNA binding	mitochondrion|mitochondrial small ribosomal subunit
YLR415C_p	YLR415C	YLR415C	hom	Uncharacterized	0.252824953036252	0.400201742126614	no	1857	0.400967983129771	1341	NA	FT		MITOCHONDRION		Putative protein of unknown function; YLR415C is not an essential gene	biological_process	molecular_function	cellular_component
YFR043C	YFR043C	IRC6	hom	Verified	0.252363081275118	0.4003802168292	no	1858	0.399204842107825	1319	NA					Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci	biological_process	molecular_function	cellular_component
YGL234W	YGL234W	ADE5,7	hom	Verified	0.25227652403663	0.400413666258891	no	1859	0.399929983250313	1321	NA	FT	NUCLEOTIDE METABOLISM			Bifunctional enzyme of the 'de novo' purine nucleotide biosynthetic pathway, contains aminoimidazole ribotide synthetase and glycinamide ribotide synthetase activities	purine nucleobase metabolic process|purine nucleotide biosynthetic process|'de novo' IMP biosynthetic process	phosphoribosylamine-glycine ligase activity|phosphoribosylformylglycinamidine cyclo-ligase activity	cytoplasm
YKL051W	YKL051W	SFK1	hom	Verified	0.252189923685862	0.400447133079984	no	1860	0.379430194176718	1234	NA	FT	LIPID METABOLISM|SIGNALING|CYTOSKELETON ORGANIZATION	PLASMA MEMBRANE		Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane	vacuole organization|inositol lipid-mediated signaling|actin cytoskeleton organization	molecular_function	integral to membrane|plasma membrane
YDL226C	YDL226C	GCS1	hom	Verified	0.252151346696067	0.400462041444487	no	1861	0.420008807947596	1397	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL CYCLE|SIGNALING|NUCLEOTIDE METABOLISM|CYTOSKELETON ORGANIZATION	MITOCHONDRION|GOLGI APPARATUS|CYTOSKELETON		ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Glo3p	retrograde vesicle-mediated transport, Golgi to ER|Golgi to plasma membrane protein transport|actin filament reorganization involved in cell cycle|ER to Golgi vesicle-mediated transport	actin binding|ARF GTPase activator activity|GTPase activator activity	endosome|trans-Golgi network|endoplasmic reticulum-Golgi intermediate compartment|cytoskeleton
YNL328C	YNL328C	MDJ2	hom	Verified	0.251085492569289	0.40087400597786	no	1862	0.41718065197584	1387	NA	FT	PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Constituent of the mitochondrial import motor associated with the presequence translocase; function overlaps with that of Pam18p; stimulates the ATPase activity of Ssc1p to drive mitochondrial import; contains a J domain	protein import into mitochondrial matrix	protein transporter activity|ATPase activator activity	mitochondrial inner membrane|presequence translocase-associated import motor
YOR321W	YOR321W	PMT3	hom	Verified	0.251033406670441	0.400894140589367	no	1863	0.389833450113474	1303	NA	FT	CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein O-mannosyltransferase; transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt5p, can instead interact with Pmt1p in some conditions; antifungal drug target; PMT3 has a paralog, PMT2, that arose from the whole genome duplication	protein O-linked glycosylation|protein O-linked mannosylation	dolichyl-phosphate-mannose-protein mannosyltransferase activity	integral to membrane|dolichyl-phosphate-mannose-protein mannosyltransferase complex
YMR088C	YMR088C	VBA1	hom	Verified	0.250889044400754	0.400949947438137	no	1864	0.401736809063583	1331	NA					Permease of basic amino acids in the vacuolar membrane	basic amino acid transport	basic amino acid transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane
YGL026C	YGL026C	TRP5	hom	Verified	0.250125617158414	0.401245102929801	no	1865	0.46092418507389	1511	NA	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Tryptophan synthase, catalyzes the last step of tryptophan biosynthesis; regulated by the general control system of amino acid biosynthesis	tryptophan biosynthetic process	tryptophan synthase activity	nucleus|cytoplasm
YJL218W_p	YJL218W	YJL218W	hom	Uncharacterized	0.249874051868823	0.401342375210364	no	1866	0.403955106782142	1339	NA					Putative acetyltransferase; similar to bacterial galactoside O-acetyltransferases; induced by oleate in an OAF1/PIP2-dependent manner; promoter contains an oleate response element consensus sequence; non-essential gene	biological_process	acetyltransferase activity	cellular_component
YPR138C	YPR138C	MEP3	hom	Verified	0.249817499839938	0.401364242919727	no	1867	0.399201540805855	1314	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Ammonium permease of high capacity and low affinity; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation ammonia permease	nitrogen utilization|ammonium transport	ammonium transmembrane transporter activity	integral to membrane|plasma membrane
YBR148W	YBR148W	YSW1	hom	Verified	0.249707475163137	0.401406788479288	no	1868	0.383857708704088	1289	NA	FT	MEMBRANE ORGANIZATION			Protein required for normal prospore membrane formation; interacts with Gip1p, which is the meiosis-specific regulatory subunit of the Glc7p protein phosphatase; expressed specifically in spores and localizes to the prospore membrane	ascospore-type prospore membrane assembly	molecular_function	prospore membrane
YHR204W	YHR204W	MNL1	hom	Verified	0.249153115665315	0.401621172116644	no	1869	0.402053686662593	1325	NA	FT	PROTEOLYSIS	ENDOPLASMIC RETICULUM		Alpha-1,2-specific exomannosidase of the endoplasmic reticulum; in complex with Pdi1p, generates a Man7GlcNac2 oligosaccharide signal on glycoproteins destined for ubiquitin-proteasome degradation	ER-associated protein catabolic process	carbohydrate binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	endoplasmic reticulum lumen
YHR001W	YHR001W	OSH7	hom	Verified	0.248702773684884	0.401795351576938	no	1870	0.391971717404624	1315	NA	FT	VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT	ENDOPLASMIC RETICULUM		Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability	maintenance of cell polarity|endocytosis|exocytosis|sterol transport|sterol metabolic process|late endosome to vacuole transport	lipid binding|oxysterol binding	integral to membrane|cortical endoplasmic reticulum|cytoplasm
YPR022C_p	YPR022C	YPR022C	hom	Uncharacterized	0.247634397762023	0.402208646957288	no	1871	0.41110888381134	1362	NA	FT		NUCLEUS		Putative transcription factor, as suggested by computational analysis; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS	biological_process	sequence-specific DNA binding	nucleus|cytoplasm
YDR320C	YDR320C	SWA2	hom	Verified	0.246824225723399	0.402522130509386	no	1872	0.425866976283072	1369	NA	FF|FT	VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|NUCLEOTIDE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Auxilin-like protein involved in vesicular transport; clathrin-binding protein required for uncoating of clathrin-coated vesicles	positive regulation of ATPase activity|endoplasmic reticulum inheritance|clathrin coat disassembly	ubiquitin binding|clathrin binding	endoplasmic reticulum membrane
YCR007C_p	YCR007C	YCR007C	hom	Uncharacterized	0.246590426457112	0.402612607188044	no	1873	0.408714565199065	1350	NA					Putative integral membrane protein, member of DUP240 gene family; YCR007C is not an essential gene	biological_process	molecular_function	cellular_component
YNL080C	YNL080C	EOS1	hom	Verified	0.24582529171233	0.402908738875141	no	1874	0.415031646203126	1372	NA	FT	CARBOHYDRATE METABOLISM|RESPONSE TO OXIDATIVE STRESS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein involved in N-glycosylation; deletion mutation confers sensitivity to exidative stress and shows synthetic lethality with mutations in the spindle checkpoint genes BUB3 and MAD1; YNL080C is not an essential gene	cellular response to oxidative stress|protein N-linked glycosylation	molecular_function	integral to membrane|endoplasmic reticulum membrane
YDR530C	YDR530C	APA2	hom	Verified	0.245440268798886	0.403057776170281	no	1875	0.378715585604838	1263	NA	FT	NUCLEOTIDE METABOLISM	NUCLEUS		Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase II; AP4A phosphorylase involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; APA2 has a paralog, APA1, that arose from the whole genome duplication	nucleoside catabolic process	bis(5'-nucleosyl)-tetraphosphatase activity	nucleus|cytoplasm
YBR134W_d	YBR134W	YBR134W	hom	Dubious	0.244798157385994	0.403306360356399	no	1876	0.399956840199866	1321	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YEL037C	YEL037C	RAD23	hom	Verified	0.244108665815233	0.403573330594649	no	1877	0.388500217672755	1270	NA	FT	RESPONSE TO DNA DAMAGE|PROTEOLYSIS	NUCLEUS|MITOCHONDRION		Protein with ubiquitin-like N terminus, subunit of Nuclear Excision Repair Factor 2 (NEF2) with Rad4p that binds damaged DNA; enhances protein deglycosylation activity of Png1p; also involved, with Rad4p, in ubiquitylated protein turnover	proteasomal ubiquitin-dependent protein catabolic process|nucleotide-excision repair, DNA damage recognition|ER-associated protein catabolic process|protein deglycosylation	damaged DNA binding|ubiquitin binding|peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity|protein binding, bridging	proteasome complex|mitochondrion|nucleotide-excision repair factor 2 complex
YBR218C	YBR218C	PYC2	hom	Verified	0.243905586425821	0.403651971242172	no	1878	0.412102148777175	1378	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM			Pyruvate carboxylase isoform; cytoplasmic enzyme that converts pyruvate to oxaloacetate; differentially regulated than isoform Pyc1p; mutations in the human homolog are associated with lactic acidosis; PYC2 has a paralog, PYC1, that arose from the whole genome duplication	NADPH regeneration|gluconeogenesis	pyruvate carboxylase activity	cytosol
YOR201C	YOR201C	MRM1	hom	Verified	0.243618038397992	0.403763328263997	no	1879	0.40031438374556	1305	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	MITOCHONDRION		Ribose methyltransferase that modifies a functionally critical, conserved nucleotide in mitochondrial 21S rRNA	rRNA modification	rRNA (guanine-N1-)-methyltransferase activity	mitochondrion
YJL059W	YJL059W	YHC3	hom	Verified	0.243085389116054	0.403969624799685	no	1880	0.399565410728725	1331	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|VACUOLAR TRANSPORT			Vacuolar membrane protein involved in the ATP-dependent transport of arginine into the vacuole and possibly in balancing ion homeostasis; homolog of human CLN3 involved in Batten disease (juvenile onset neuronal ceroid lipofuscinosis)	basic amino acid transport|regulation of intracellular pH|arginine transport	molecular_function	integral to membrane|fungal-type vacuole
YDR445C_d	YDR445C	YDR445C	hom	Dubious	0.242307874936956	0.404270806125935	no	1881	0.42337689664417	1402	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YIR035C_p	YIR035C	YIR035C	hom	Uncharacterized	0.24129708216919	0.404662436091243	no	1882	0.383743056925478	1249	NA	FT	OXIDATION-REDUCTION PROCESS			Putative cytoplasmic short-chain dehydrogenase/reductase	biological_process	molecular_function	integral to membrane|cytoplasm
YKL043W	YKL043W	PHD1	hom	Verified	0.240675138000435	0.404903454816071	no	1883	0.384045710777214	1246	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Transcriptional activator that enhances pseudohyphal growth; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; regulates expression of FLO11, an adhesin required for pseudohyphal filament formation; similar to StuA, an A. nidulans developmental regulator; potential Cdc28p substrate; PHD1 has a paralog, SOK2, that arose from the whole genome duplication	pseudohyphal growth|positive regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	nucleus
YER150W	YER150W	SPI1	hom	Verified	0.239185155732717	0.40548100632995	no	1884	0.40492792973661	1330	NA					GPI-anchored cell wall protein involved in weak acid resistance; basal expression requires Msn2p/Msn4p; expression is induced under conditions of stress and during the diauxic shift; similar to Sed1p	response to acid	molecular_function	fungal-type cell wall
YKR050W	YKR050W	TRK2	hom	Verified	0.23914089273656	0.405498166843443	no	1885	0.420503785713307	1392	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Component of the Trk1p-Trk2p potassium transport system; TRK2 has a paralog, TRK1, that arose from the whole genome duplication	cellular potassium ion homeostasis	potassium ion transmembrane transporter activity	integral to membrane|plasma membrane
YOR264W	YOR264W	DSE3	hom	Verified	0.237256668190028	0.406228838093189	no	1886	0.39410874390016	1307	NA	FT	CELL CYCLE	SITE OF POLARIZED GROWTH		Daughter cell-specific protein, may help establish daughter fate; relocalizes from bud neck to cytoplasm upon DNA replication stress	biological_process	molecular_function	cellular bud neck
YPL177C	YPL177C	CUP9	hom	Verified	0.237108157003815	0.406286442207891	no	1887	0.409441322804371	1362	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Homeodomain-containing transcriptional repressor; regulates expression of PTR2, which encodes a major peptide transporter; imported peptides activate ubiquitin-dependent proteolysis, resulting in degradation of Cup9p and de-repression of PTR2 transcription; CUP9 has a paralog, TOS8, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress	negative regulation of dipeptide transport by negative regulation of transcription from RNA polymerase II promoter|negative regulation of oligopeptide transport by negative regulation of transcription from RNA polymerase II promoter	RNA polymerase II repressing transcription factor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity	nucleus
YMR141C_d	YMR141C	YMR141C	hom	Dubious	0.236950530972351	0.406347583982961	no	1888	0.408587000727533	1351	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YBL060W	YBL060W	YEL1	hom	Verified	0.236415744192035	0.406555040161111	no	1889	0.416766717634067	1362	NA	FT	PROTEIN LOCALIZATION|LIPID METABOLISM|SIGNALING	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Guanine nucleotide exchange factor specific for Arf3p; localized to the bud neck and tip; required for localization of Arf3p to the bud neck and tip	positive regulation of phosphatidylinositol biosynthetic process|protein localization|actin cortical patch localization	ARF guanyl-nucleotide exchange factor activity	cellular bud neck|cellular bud tip|cytoplasm
YLR304C	YLR304C	ACO1	hom	Verified	0.236194879741352	0.406640726253735	no	1890	0.45876729730925	1507	NA	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Aconitase, required for the tricarboxylic acid (TCA) cycle and also independently required for mitochondrial genome maintenance; phosphorylated; component of the mitochondrial nucleoid; mutation leads to glutamate auxotrophy	propionate metabolic process|glutamate biosynthetic process|tricarboxylic acid cycle|mitochondrial genome maintenance|citrate metabolic process	double-stranded DNA binding|aconitate hydratase activity|single-stranded DNA binding	mitochondrial nucleoid|cytosol|mitochondrion|mitochondrial matrix
YGR126W_p	YGR126W	YGR126W	hom	Uncharacterized	0.236134563994718	0.406664126997029	no	1891	0.399181337498122	1310	NA	FT		NUCLEUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS	biological_process	molecular_function	nucleus|cytoplasm
YDR176W	YDR176W	NGG1	hom	Verified	0.23612580004033	0.406667527182405	no	1892	0.42697573093248	1404	NA	FF|FT	CHROMATIN ORGANIZATION	NUCLEUS	HISTONE ACETYLTRANSFERASE	Transcriptional regulator involved in glucose repression of Gal4p-regulated genes; component of transcriptional adaptor and histone acetyltransferase complexes, the ADA complex, the SAGA complex, and the SLIK complex	histone acetylation|chromatin modification	histone acetyltransferase activity|transcription cofactor activity	SLIK (SAGA-like) complex|Ada2/Gcn5/Ada3 transcription activator complex|SAGA complex
YHL021C	YHL021C	AIM17	hom	Verified	0.235590520860166	0.406875214851951	no	1893	0.402300484865354	1316	NA	FT	OXIDATION-REDUCTION PROCESS	MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays reduced frequency of mitochondrial genome loss	biological_process	molecular_function	mitochondrion
YBR041W	YBR041W	FAT1	hom	Verified	0.235346922002626	0.406969739587397	no	1894	0.449704191581973	1503	NA	FT	KETONE METABOLISM|LIPID METABOLISM	ENDOPLASMIC RETICULUM|PLASMA MEMBRANE		Very long chain fatty acyl-CoA synthetase and long chain fatty acid transporter; activates imported fatty acids with a preference for very long lengths (C20-C26); has a separate function in the transport of long chain fatty acids	very long-chain fatty acid metabolic process|long-chain fatty acid transport	very long-chain fatty acid-CoA ligase activity|long-chain fatty acid transporter activity	intrinsic to internal side of plasma membrane|integral to membrane|endoplasmic reticulum|lipid particle|peroxisome
YMR039C	YMR039C	SUB1	hom	Verified	0.2353315511186	0.406975704200909	no	1895	0.390723788163796	1286	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Transcriptional coactivator; facilitates elongation through factors that modify RNAP II; role in peroxide resistance involving Rad2p; role in the hyperosmotic stress response through polymerase recruitment at RNAP II and RNAP III genes; protein abundance increases in response to DNA replication stress	termination of RNA polymerase II transcription|hyperosmotic response|RNA polymerase III transcriptional preinitiation complex assembly|positive regulation of transcription elongation from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter in response to stress|positive regulation of transcription from RNA polymerase III promoter	transcription coactivator activity	nucleus
YDL009C_p	YDL009C	YDL009C	hom	Uncharacterized	0.235242928196527	0.407010094411988	no	1896	0.405781798115806	1339	NA					Protein of unknown function; mRNA identified as translated by ribosome profiling data; partially overlaps the verified ORF YDL010W; YDL009C is not an essential gene	biological_process	molecular_function	cellular_component
YDR074W	YDR074W	TPS2	hom	Verified	0.235174588808466	0.40703661406759	no	1897	0.499570558754747	1674	NA	FT	CARBOHYDRATE METABOLISM	MITOCHONDRION		Phosphatase subunit of the trehalose-6-P synthase/phosphatase complex; involved in synthesis of the storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway; protein abundance increases in response to DNA replication stress	trehalose biosynthetic process|response to stress	trehalose-phosphatase activity	mitochondrion|alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)
YBL078C	YBL078C	ATG8	hom	Verified	0.235115006750562	0.407059735717764	no	1898	0.44819381408065	1471	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS	ENDOMEMBRANE SYSTEM		Component of autophagosomes and Cvt vesicles; unique ubiquitin-like protein whose &#65532;conjugation target is the lipid phosphatidylethanolamine (PE); Atg8p-PE is anchored to membranes, is involved in phagophore expansion, and may mediate membrane fusion during autophagosome formation; deconjugation of Atg8p-PE is required for efficient autophagosome biogenesis	piecemeal microautophagy of nucleus|mitochondrion degradation|cellular membrane fusion|ER to Golgi vesicle-mediated transport|CVT pathway|autophagic vacuole assembly	molecular_function	cytosol|fungal-type vacuole membrane|pre-autophagosomal structure|extrinsic to membrane|autophagic vacuole
YBL032W	YBL032W	HEK2	hom	Verified	0.234676369302737	0.407229965073609	no	1899	0.404729040888092	1338	NA	FT	CHROMATIN ORGANIZATION|TRANSLATION|RNA LOCALIZATION	NUCLEUS|CHROMOSOME		RNA binding protein involved in the asymmetric localization of ASH1 mRNA; represses translation of ASH1 mRNA, an effect reversed by Yck1p-dependent phosphoryation; regulates telomere position effect and length; similarity to hnRNP-K	telomere maintenance via telomerase|intracellular mRNA localization|mRNA stabilization	mRNA binding	nuclear chromosome, telomeric region|cytoplasmic mRNA processing body|cytoplasm
YBR144C_d	YBR144C	YBR144C	hom	Dubious	0.234566806183512	0.407272487798488	no	1900	0.394469146085679	1271	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR144C is not an essential gene	Unknown	Unknown	Unknown
YMR121C	YMR121C	RPL15B	hom	Verified	0.234245074145484	0.40739736207077	no	1901	0.374071625679168	1243	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L15B; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15B has a paralog, RPL15A, that arose from the whole genome duplication; relocalizes from nucleus to nucleolus upon DNA replication stress	cytoplasmic translation	structural constituent of ribosome|RNA binding	cytosolic large ribosomal subunit
YLL028W	YLL028W	TPO1	hom	Verified	0.234046637144805	0.407474386373907	no	1902	0.372592851272695	1210	NA	FT		PLASMA MEMBRANE		Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; recognizes spermine, putrescine, and spermidine; catalyzes uptake of polyamines at alkaline pH and excretion at acidic pH; phosphorylation enhances activity and sorting to the plasma membrane	spermidine transport|putrescine transport|spermine transport	spermidine transmembrane transporter activity|spermine transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane|cellular bud membrane|plasma membrane
YLR097C	YLR097C	HRT3	hom	Verified	0.233617780344457	0.407640861477973	no	1903	0.376129485103062	1237	NA	FT	PROTEOLYSIS		UBIQUITIN LIGASE COMPLEX	Putative SCF-ubiquitin ligase F-box protein, based on both genetic and physical interactions and sequence similarity; identified in association with Cdc53p, Skp1p and Ubi4 in large and small-scale studies	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|cellular response to methylmercury	ubiquitin-protein ligase activity|protein binding, bridging	SCF ubiquitin ligase complex
YLR351C	YLR351C	NIT3	hom	Verified	0.233444609128449	0.407708088403794	no	1904	0.4009661296742	1333	NA	FT		MITOCHONDRION		Nit protein, one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member	biological_process	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	mitochondrion|cytoplasm
YKR019C	YKR019C	IRS4	hom	Verified	0.233214081338199	0.407797585984462	no	1905	0.459055016984165	1498	NA	FF|FT	LIPID METABOLISM|SIGNALING|CELL WALL ORG/BIOGENESIS|RESPONSE TO NUTRIENT LEVELS|GENE SILENCING	MITOCHONDRION		EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; IRS4 has a paralog, TAX4, that arose from the whole genome duplication	autophagy|fungal-type cell wall organization|chromatin silencing at rDNA|inositol lipid-mediated signaling|CVT pathway|cellular response to starvation	molecular_function	mitochondrion|pre-autophagosomal structure
YCR050C_p	YCR050C	YCR050C	hom	Uncharacterized	0.233133124025418	0.40782901710541	no	1906	0.362420490986109	1201	NA					Non-essential protein of unknown function; deletion mutant is synthetically sick or lethal with alpha-synuclein	biological_process	molecular_function	cellular_component
YML094W	YML094W	GIM5	hom	Verified	0.232694225922929	0.407999426601755	no	1907	0.385014988389557	1282	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS			Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it	tubulin complex assembly	tubulin binding	prefoldin complex|cytoplasm
YBR285W_p	YBR285W	YBR285W	hom	Uncharacterized	0.231762882861693	0.40836109366654	no	1908	0.421110715306982	1406	NA					Putative protein of unknown function; YBR285W is not an essential gene	biological_process	molecular_function	cellular_component
YPL196W	YPL196W	OXR1	hom	Verified	0.231208553379963	0.408576392692049	no	1909	0.401513874826607	1348	NA	FT	RESPONSE TO OXIDATIVE STRESS	MITOCHONDRION		Protein of unknown function required for normal levels of resistance to oxidative damage, null mutants are sensitive to hydrogen peroxide; member of a conserved family of proteins found in eukaryotes	cellular response to oxidative stress	molecular_function	mitochondrion
YPR007C	YPR007C	REC8	hom	Verified	0.230689645881487	0.408777958990098	no	1910	0.414395199506798	1345	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME		Meiosis-specific component of sister chromatid cohesion complex; maintains cohesion between sister chromatids during meiosis I; maintains cohesion between centromeres of sister chromatids until meiosis II; homolog of S. pombe Rec8p	synaptonemal complex assembly|protein localization to chromosome, centromeric region|reciprocal meiotic recombination|meiotic sister chromatid cohesion	molecular_function	condensed nuclear chromosome|condensed nuclear chromosome, centromeric region
YKR065C	YKR065C	PAM17	hom	Verified	0.230643437860081	0.408795909371209	no	1911	0.403499762155751	1343	NA	FT	PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Constituent of the TIM23 complex; proposed alternatively to be a component of the import motor (PAM complex) or to interact with and modulate the core TIM23 (Translocase of the Inner mitochondrial Membrane) complex; protein abundance increases in response to DNA replication stress	protein import into mitochondrial matrix	molecular_function	mitochondrion|presequence translocase-associated import motor
YER045C	YER045C	ACA1	hom	Verified	0.229917327021342	0.409078005978787	no	1912	0.405256866871073	1335	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		ATF/CREB family basic leucine zipper (bZIP) transcription factor; binds as a homodimer to the ATF/CREB consensus sequence TGACGTCA; important for carbon source utilization; target genes include GRE2 and COS8; ACA1 has a paralog, CST6, that arose from the whole genome duplication	positive regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YHR051W	YHR051W	COX6	hom	Verified	0.22954236164068	0.409223699794074	no	1913	0.406818729861245	1348	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Subunit VI of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; expression is regulated by oxygen levels	mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity	mitochondrion|integral to membrane|mitochondrial respiratory chain complex IV
YOL118C_d	YOL118C	YOL118C	hom	Dubious	0.229504867987413	0.409238268744694	no	1914	0.427770652976569	1397	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDR380W	YDR380W	ARO10	hom	Verified	0.22894065684559	0.409457520023352	no	1915	0.40271067420235	1318	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Phenylpyruvate decarboxylase, catalyzes decarboxylation of phenylpyruvate to phenylacetaldehyde, which is the first specific step in the Ehrlich pathway	L-phenylalanine catabolic process|methionine catabolic process to 3-methylthiopropanol|tryptophan catabolic process|branched-chain amino acid catabolic process to alcohol via Ehrlich pathway|aromatic amino acid family catabolic process to alcohol via Ehrlich pathway|leucine catabolic process	pyruvate decarboxylase activity|carboxy-lyase activity|phenylpyruvate decarboxylase activity	cytoplasm
YGL258W	YGL258W	VEL1	hom	Verified	0.228411698739314	0.409663097770322	no	1916	0.424148659298315	1400	NA					Protein of unknown function; highly induced in zinc-depleted conditions and has increased expression in NAP1 deletion mutants; VEL1 has paralog YOR387C	biological_process	molecular_function	cytosol
YHR135C	YHR135C	YCK1	hom	Verified	0.227124823508429	0.41016334101435	no	1917	0.407501159886984	1330	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CELL DIVISION|PROTEIN PHOSPHORYLATION	ENDOPLASMIC RETICULUM|MITOCHONDRION|PLASMA MEMBRANE		Palmitoylated plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck2p in morphogenesis, proper septin assembly, endocytic trafficking; YCK1 has a paralog, YCK2, that arose from the whole genome duplication	cell morphogenesis|endocytosis|protein phosphorylation|cytokinesis|response to glucose stimulus	protein serine/threonine kinase activity|protein kinase activity	mitochondrion|endoplasmic reticulum|plasma membrane
YOR293C-A_p	YOR293C-A	YOR293C-A	hom	Uncharacterized	0.226909424380171	0.410247086795517	no	1918	0.40112290487874	1301	NA					Putative protein of unknown function; identified by expression profiling and mass spectrometry	biological_process	molecular_function	cellular_component
YNL284C	YNL284C	MRPL10	hom	Verified	0.226875322217931	0.410260345869982	no	1919	0.411724975757314	1367	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL10 and YmL18) on two-dimensional SDS gels	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YPR054W	YPR054W	SMK1	hom	Verified	0.226789834981407	0.410293584143925	no	1920	0.400608836212956	1339	NA	FT	SIGNALING|CELL WALL ORG/BIOGENESIS|PROTEIN PHOSPHORYLATION	MITOCHONDRION		Middle sporulation-specific mitogen-activated protein kinase (MAPK) required for production of the outer spore wall layers; negatively regulates activity of the glucan synthase subunit Gsc2p	ascospore wall assembly|protein phosphorylation|negative regulation of sporulation resulting in formation of a cellular spore	MAP kinase activity	mitochondrion
YMR269W	YMR269W	TMA23	hom	Verified	0.225757606215158	0.410694975587851	no	1921	0.410845807836971	1355	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS	NUCLEUS		Nucleolar protein implicated in ribosome biogenesis; deletion extends chronological lifespan	ribosomal small subunit biogenesis	molecular_function	ribosome|nucleolus
YLR239C	YLR239C	LIP2	hom	Verified	0.225242661259552	0.410895251567535	no	1922	0.475441730745889	1575	NA	FF|FT	KETONE METABOLISM|LIPID METABOLISM|COFACTOR METABOLISM	MITOCHONDRION		Lipoyl ligase, involved in the modification of mitochondrial enzymes by the attachment of lipoic acid groups	protein lipoylation	ligase activity	mitochondrion
YLR260W	YLR260W	LCB5	hom	Verified	0.22508388095478	0.410957010198115	no	1923	0.424633510688516	1419	NA	FT	LIPID METABOLISM|SIGNALING|PROTEIN PHOSPHORYLATION	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Minor sphingoid long-chain base kinase, paralog of Lcb4p responsible for few percent of the total activity, possibly involved in synthesis of long-chain base phosphates, which function as signaling molecules	response to heat|calcium-mediated signaling|sphingolipid metabolic process	D-erythro-sphingosine kinase activity	Golgi apparatus|membrane
YKL053W_d	YKL053W	YKL053W	hom	Dubious	0.224922138209091	0.411019923358698	no	1924	0.392434794577203	1307	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF ASK1	Unknown	Unknown	Unknown
YKR033C_d	YKR033C	YKR033C	hom	Dubious	0.224213290138031	0.411295671339386	no	1925	0.410346932948758	1346	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene DAL80	Unknown	Unknown	Unknown
YMR226C	YMR226C	YMR226C	hom	Verified	0.22412283671412	0.411330861653286	no	1926	0.410500960389004	1343	NA	FT	OXIDATION-REDUCTION PROCESS	NUCLEUS		NADP(+)-dependent dehydrogenase; acts on serine, L-allo-threonine, and other 3-hydroxy acids; green fluorescent protein fusion protein localizes to the cytoplasm and nucleus; may interact with ribosomes, based on co-purification experiments	metabolic process	oxidoreductase activity|oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor|carbonyl reductase (NADPH) activity	integral to membrane|ribosome|nucleus|cytoplasm
YJL084C	YJL084C	ALY2	hom	Verified	0.224008841295048	0.411375211842724	no	1927	0.398525062042606	1336	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION			Alpha arrestin that controls nutrient-mediated intracellular sorting of permease Gap1p; interacts with AP-1 subunit Apl4p; phosphorylated by Npr1p and also by cyclin-CDK complex Pcl7p-Pho85p; promotes endocytosis of plasma membrane proteins; ALY2 has a paralog, ALY1, that arose from the whole genome duplication	Unknown|regulation of intracellular transport|ubiquitin-dependent endocytosis	protein binding, bridging|ubiquitin protein ligase binding	late endosome|cytoplasm|early endosome
YDR443C	YDR443C	SSN2	hom	Verified	0.223898048684207	0.411418317057251	no	1928	0.395139437806179	1284	NA	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for stable association of Srb10p-Srb11p kinase; essential for transcriptional regulation	negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter by galactose	RNA polymerase II transcription coactivator activity|RNA polymerase II transcription factor recruiting transcription factor activity	mediator complex
YMR057C_d	YMR057C	YMR057C	hom	Dubious	0.223576423195942	0.411543455426121	no	1929	0.41143372951055	1346	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF AAC1	Unknown	Unknown	Unknown
YFR012W	YFR012W	DCV1	hom	Verified	0.223096696949659	0.411730124514627	no	1930	0.40778649442901	1311	NA					Protein of unknown function; deletion mutant shows strong genetic interaction with cdc28-as1 mutant in the presence of 1-NM-PP1; DCV1 has a paralog, YOL019W, that arose from the whole genome duplication	biological_process	molecular_function	integral to membrane
YMR305C	YMR305C	SCW10	hom	Verified	0.22293182345267	0.411794284021685	no	1931	0.418055291855821	1389	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	ENDOPLASMIC RETICULUM		Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on mutant phenotype and its regulation by Ste12p	conjugation with cellular fusion	glucosidase activity	fungal-type cell wall|extracellular region|endoplasmic reticulum|cytoplasm
YPR061C	YPR061C	JID1	hom	Verified	0.222609309719831	0.411919795073603	no	1932	0.402712814321998	1335	NA	FT		MITOCHONDRION		Probable Hsp40p co-chaperone, has a DnaJ-like domain and appears to be involved in ER-associated degradation of misfolded proteins containing a tightly folded cytoplasmic domain; inhibits replication of Brome mosaic virus in S. cerevisiae	biological_process	molecular_function	mitochondrion
YDR075W	YDR075W	PPH3	hom	Verified	0.222332808350163	0.41202740689998	no	1933	0.397266418907699	1302	NA	FT	CELL CYCLE|SIGNALING|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Catalytic subunit of protein phosphatase PP4 complex; active complex is composed of Pph3p and Psy2p, with Psy4p apparently providing additional substrate specificity in some cases; regulates recovery from the DNA damage checkpoint and also the gene conversion- and single-strand annealing-mediated pathways of meiotic double-strand break repair; involved in activation of Gln3p to alleviate nitrogen catabolite repression; Pph3p and Psy2p localize to foci on meiotic chromosomes	Unknown|signal transduction involved in meiotic recombination checkpoint|double-strand break repair via homologous recombination|protein dephosphorylation|positive regulation of nitrogen compound metabolic process	protein serine/threonine phosphatase activity	condensed nuclear chromosome|nucleus|cytoplasm
YGL176C_p	YGL176C	YGL176C	hom	Uncharacterized	0.222320292887741	0.412032277961053	no	1934	0.420196275763368	1362	NA					Putative protein of unknown function; deletion mutant is viable and has no detectable phenotype	biological_process	molecular_function	cellular_component
YDL068W_d	YDL068W	YDL068W	hom	Dubious	0.222129583947759	0.412106504213566	no	1935	0.422442534007869	1394	NA					Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YNL239W	YNL239W	LAP3	hom	Verified	0.222063199164715	0.412132342721177	no	1936	0.406624905650083	1334	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM|PROTEOLYSIS	MITOCHONDRION		Cysteine aminopeptidase with homocysteine-thiolactonase activity; protects cells against homocysteine toxicity; has bleomycin hydrolase activity in vitro; transcription is regulated by galactose via Gal4p; orthologous to human BLMH	response to antibiotic|negative regulation of transcription from RNA polymerase II promoter|homocysteine catabolic process	double-stranded DNA binding|cysteine-type peptidase activity|mRNA binding|single-stranded DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding	mitochondrion|cytoplasm
YJL131C	YJL131C	AIM23	hom	Verified	0.22204575630484	0.412139131952717	no	1937	0.406726886969246	1316	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial translation initiation factor 3 (IF3, mIF3); evolutionarily conserved; binds to E. coli ribosomes in vitro; null mutant displays severe respiratory growth defect and elevated frequency of mitochondrial genome loss	positive regulation of mitochondrial translational initiation	ribosome binding|translation initiation factor activity	mitochondrion
YKL205W	YKL205W	LOS1	hom	Verified	0.221695790984609	0.412275353448496	no	1938	0.423583166474573	1395	NA	FT	RNA PROCESSING|RNA LOCALIZATION	NUCLEUS|MITOCHONDRION		Nuclear pore protein involved in nuclear export of pre-tRNA and in re-export of mature tRNAs after their retrograde import from the cytoplasm	tRNA re-export from nucleus|tRNA splicing, via endonucleolytic cleavage and ligation|tRNA export from nucleus	tRNA binding|Ran GTPase binding	mitochondrion|integral to membrane|nuclear matrix|cytoplasm
YBR182C	YBR182C	SMP1	hom	Verified	0.221514352348153	0.412345981300216	no	1939	0.398204123612928	1296	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Putative transcription factor of the MADS-box family; involved in regulating the response to osmotic stress; SMP1 has a paralog, RLM1, that arose from the whole genome duplication	positive regulation of transcription from RNA polymerase II promoter in response to osmotic stress	DNA binding, bending|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	nucleus|cytoplasm
YER180C-A	YER180C-A	SLO1	hom	Verified	0.221233820534687	0.412455188321217	no	1940	0.42096299682091	1366	NA	FT	PROTEIN LOCALIZATION			Protein interacting with Arl3p, which is a GTPase of the Ras superfamily involved in vesicle-tethering at the Golgi; putative ortholog of human SCOCO	intracellular protein transport	small GTPase regulator activity	cytoplasm
YHR210C_p	YHR210C	YHR210C	hom	Uncharacterized	0.219796075604985	0.413014988058474	no	1941	0.416639148308389	1380	NA	FT	CARBOHYDRATE METABOLISM			Putative aldose 1-epimerase superfamily protein; non-essential gene; highly expressed under anaeorbic conditions	biological_process	molecular_function	cellular_component
YIR028W	YIR028W	DAL4	hom	Verified	0.219526375290973	0.413120018195826	no	1942	0.413069153932821	1373	NA					Allantoin permease; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation	allantoin catabolic process|allantoin transport	allantoin uptake transmembrane transporter activity	integral to membrane|membrane
YBR288C	YBR288C	APM3	hom	Verified	0.219320041215914	0.413200375642975	no	1943	0.422742965836437	1398	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Mu3-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway	Golgi to vacuole transport|vesicle-mediated transport	molecular_function	AP-3 adaptor complex
YCR084C	YCR084C	TUP1	hom	Verified	0.219098874498565	0.413286513746734	no	1944	0.409082037569615	1361	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|LIPID METABOLISM|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		General repressor of transcription, forms complex with Cyc8p, involved in the establishment of repressive chromatin structure through interactions with histones H3 and H4, appears to enhance expression of some genes	nucleosome positioning|regulation of transcription from RNA polymerase II promoter in response to osmotic stress|histone exchange|negative regulation of mating-type specific transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter by glucose|negative regulation of dipeptide transport by negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter in response to hypoxia|negative regulation of transcription from RNA polymerase II promoter during mitosis|Unknown	ubiquitin binding|histone deacetylase binding|histone binding|phosphatidylinositol-3,5-bisphosphate binding|RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription|mediator complex binding	nucleus|transcriptional repressor complex
YNL016W	YNL016W	PUB1	hom	Verified	0.219093036752141	0.413288787438374	no	1945	0.387753468423095	1299	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS	NUCLEUS		Poly (A)+ RNA-binding protein; abundant mRNP-component protein that binds mRNA and is required for stability of many mRNAs; component of glucose deprivation induced stress granules, involved in P-body-dependent granule assembly; protein abundance increases in response to DNA replication stress	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|stress granule assembly|regulation of mRNA stability	mRNA binding|poly(U) RNA binding	nucleus|cytoplasmic stress granule|cytoplasm
YBR133C	YBR133C	HSL7	hom	Verified	0.218621847686459	0.413472316236793	no	1946	0.414544452408987	1395	NA	FT	CELL CYCLE|CHROMATIN ORGANIZATION|CELL DIVISION	SITE OF POLARIZED GROWTH		Protein arginine N-methyltransferase; exhibits septin and Hsl1p-dependent bud neck localization and periodic Hsl1p-dependent phosphorylation; required along with Hsl1p for bud neck recruitment, phosphorylation, and degradation of Swe1p; relocalizes away from bud neck upon DNA replication stress	G2/M transition of mitotic cell cycle|regulation of cell cycle	protein-arginine omega-N symmetric methyltransferase activity|protein-arginine omega-N monomethyltransferase activity	cellular bud neck
YGR109C	YGR109C	CLB6	hom	Verified	0.218226227175892	0.413626425580672	no	1947	0.410924813954806	1359	NA	FT	CELL CYCLE|CELL DIVISION|PROTEIN PHOSPHORYLATION	NUCLEUS		B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1	regulation of cyclin-dependent protein kinase activity|G1/S transition of mitotic cell cycle|regulation of S phase of mitotic cell cycle|premeiotic DNA replication	cyclin-dependent protein kinase regulator activity	cellular_component
YGL151W	YGL151W	NUT1	hom	Verified	0.218029831231427	0.41370293426791	no	1948	0.415933584965399	1372	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS|MITOCHONDRION		Component of the RNA polymerase II mediator complex, which is required for transcriptional activation and also has a role in basal transcription	regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	molecular_function	mitochondrion|mediator complex|nucleus
YGR214W	YGR214W	RPS0A	hom	Verified	0.217461392911204	0.413924395531026	no	1949	0.417421832451935	1374	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION		RIBOSOME	Ribosomal 40S subunit protein S0A; required for maturation of 18S rRNA along with Rps0Bp; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2; RPS0A has a paralog, RPS0B, that arose from the whole genome duplication;	cytoplasmic translation|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|rRNA export from nucleus|ribosomal small subunit assembly|endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome	cytosolic small ribosomal subunit|90S preribosome
YHL035C	YHL035C	VMR1	hom	Verified	0.217179671414319	0.41403416323382	no	1950	0.421432350006112	1398	NA	FT	NUCLEOTIDE METABOLISM	MITOCHONDRION		Vacuolar membrane protein involved in multiple drug resistance and metal sensitivity; ATP-binding cassette (ABC) family member involved in drug transport; potential Cdc28p substrate; induced under respiratory conditions	transport|response to drug|response to metal ion|drug transport	ATPase activity, coupled to transmembrane movement of substances	fungal-type vacuole membrane|mitochondrion|integral to membrane|ribosome
YER103W	YER103W	SSA4	hom	Verified	0.217003661003586	0.414102745926868	no	1951	0.408997511806084	1365	NA	FT	PROTEIN LOCALIZATION	NUCLEUS		Heat shock protein that is highly induced upon stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the HSP70 family; cytoplasmic protein that concentrates in nuclei upon starvation; SSA4 has a paralog, SSA3, that arose from the whole genome duplication	protein folding|SRP-dependent cotranslational protein targeting to membrane, translocation|response to stress	unfolded protein binding|ATPase activity	nucleus|cytoplasm
YOR165W	YOR165W	SEY1	hom	Verified	0.216707526970328	0.414218140861129	no	1952	0.42192057164303	1390	NA	FT	MEMBRANE ORGANIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Dynamin-like GTPase that mediates homotypic ER fusion; has a role in ER morphology; interacts physically and genetically with Yop1p and Rtn1p; functional ortholog of the human atlastin ATL1, defects in which cause a form of the human disease hereditary spastic paraplegia; homolog of Arabidopsis RHD3	cellular membrane organization|endoplasmic reticulum organization|endoplasmic reticulum membrane fusion|endoplasmic reticulum inheritance	GTPase activity	integral to membrane|endoplasmic reticulum|cortical endoplasmic reticulum|cytoplasm
YLR376C	YLR376C	PSY3	hom	Verified	0.215632597147793	0.414637072322601	no	1953	0.403133073350973	1341	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function; structural analysis reveals a similar DNA-binding region in both Psy3p and Csm2p and that both regions work together to form a single DNA binding site; deletion of PSY3 results in a mutator phenotype; deletion increases sensitivity to anticancer drugs oxaliplatin and cisplatin but not mitomycin C	recombinational repair|error-free translesion synthesis	molecular_function	nucleus|Shu complex|cytoplasm
YHL004W	YHL004W	MRP4	hom	Verified	0.214335381242165	0.415142764418519	no	1954	0.420379790866289	1369	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the small subunit	mitochondrial translation	structural constituent of ribosome|tRNA binding	mitochondrion|mitochondrial small ribosomal subunit
YBL098W	YBL098W	BNA4	hom	Verified	0.214176663605599	0.415204646792984	no	1955	0.405732920621985	1331	NA	FT	OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM	MITOCHONDRION		Kynurenine 3-mono oxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p; putative therapeutic target for Huntington disease	de novo NAD biosynthetic process from tryptophan	kynurenine 3-monooxygenase activity	mitochondrial outer membrane|mitochondrion
YGR124W	YGR124W	ASN2	hom	Verified	0.213980837094745	0.415281000434697	no	1956	0.407449538889174	1366	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Asparagine synthetase; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway; ASN2 has a paralog, ASN1, that arose from the whole genome duplication	asparagine biosynthetic process	asparagine synthase (glutamine-hydrolyzing) activity	cytoplasm
YCL033C	YCL033C	MXR2	hom	Verified	0.213969823027893	0.415285294964209	no	1957	0.413380024926875	1384	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|RESPONSE TO OXIDATIVE STRESS	MITOCHONDRION		Methionine-R-sulfoxide reductase, involved in the response to oxidative stress; protects iron-sulfur clusters from oxidative inactivation along with MXR1; involved in the regulation of lifespan	cellular response to oxidative stress	peptide-methionine (R)-S-oxide reductase activity	mitochondrion
YER052C	YER052C	HOM3	hom	Verified	0.21395260480858	0.415292008594636	no	1958	0.418224502664632	1384	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis	threonine biosynthetic process|methionine biosynthetic process|homoserine biosynthetic process	aspartate kinase activity	cytoplasm
YOR045W	YOR045W	TOM6	hom	Verified	0.212747709335976	0.41576187591687	no	1959	0.417552600443024	1391	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex	mitochondrial outer membrane translocase complex assembly|protein import into mitochondrial matrix	protein channel activity	mitochondrion|integral to membrane|mitochondrial outer membrane translocase complex
YOR166C	YOR166C	SWT1	hom	Verified	0.212617728213952	0.415812571243093	no	1960	0.409754763771116	1345	NA	FT		NUCLEUS		RNA endoribonuclease involved in perinuclear mRNP quality control via the turnover of aberrant, unprocessed pre-mRNAs; interacts with subunits of THO/TREX, TREX-2, and RNA polymerase II; contains a PIN (PilT N terminus) domain	nuclear mRNA surveillance of mRNP export|transcription, DNA-dependent	endoribonuclease activity	nucleus|cytoplasm
YBR072C-A_p	YBR072C-A	YBR072C-A	hom	Uncharacterized	0.21228363841863	0.415942879600401	no	1961	0.416187993754873	1367	NA					Putative protein of unknown function; identified by fungal homology and RT-PCR	biological_process	molecular_function	cellular_component
YBR024W	YBR024W	SCO2	hom	Verified	0.210726640748411	0.416550292526717	no	1962	0.413895453271517	1341	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Protein anchored to mitochondrial inner membrane; may have a redundant function with Sco1p in delivery of copper to cytochrome c oxidase; interacts with Cox2p; SCO2 has a paralog, SCO1, that arose from the whole genome duplication	copper ion transport	thioredoxin peroxidase activity	mitochondrial envelope|mitochondrion
YDR203W_d	YDR203W	YDR203W	hom	Dubious	0.2106155245137	0.416593648614504	no	1963	0.433429701046577	1436	NA	FF				Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YLR294C_d	YLR294C	YLR294C	hom	Dubious	0.209287395034212	0.417111945602418	no	1964	0.423357405755744	1399	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene ATP14	Unknown	Unknown	Unknown
YML122C_d	YML122C	YML122C	hom	Dubious	0.209097865407928	0.417185920516632	no	1965	0.460571926334536	1521	NA	FF				Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDR524W-C_p	YDR524W-C	YDR524W-C	hom	Uncharacterized	0.208964070236974	0.41723814359695	no	1966	0.419362117164462	1377	NA					Putative protein of unknown function; small ORF identified by SAGE; deletion strains are moderately sensitive to the radiomimetic drug bleomycin	biological_process	molecular_function	cellular_component
YPL245W_p	YPL245W	YPL245W	hom	Uncharacterized	0.208533088035819	0.417406374972512	no	1967	0.402545257990675	1332	NA	FT		NUCLEUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm	biological_process	molecular_function	nucleus|cytoplasm
YDL161W	YDL161W	ENT1	hom	Verified	0.208515461274223	0.417413255797616	no	1968	0.407339628107797	1359	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Epsin-like protein involved in endocytosis and actin patch assembly; functionally redundant with Ent2p; binds clathrin via a clathrin-binding domain motif at C-terminus; relocalizes from bud neck to cytoplasm upon DNA replication stress	actin filament organization|endocytosis|actin cortical patch assembly	clathrin binding	mating projection tip|actin cortical patch
YOR299W	YOR299W	BUD7	hom	Verified	0.208403745508984	0.417456866020749	no	1969	0.416388789840417	1346	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL CYCLE|CELL WALL ORG/BIOGENESIS|CELL DIVISION|CARBOHYDRATE METABOLISM	GOLGI APPARATUS		Member of the ChAPs family (Chs5p-Arf1p-binding proteins); members include Bch1p, Bch2p, Bud7p, and Chs6p; ChAPs family proteins form the exomer complex with Chs5p to mediate export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; BUD7 has a paralog, BCH1, that arose from the whole genome duplication	Golgi to plasma membrane transport|fungal-type cell wall chitin biosynthetic process|cellular bud site selection	molecular_function	trans-Golgi network transport vesicle|clathrin-coated vesicle|exomer complex
YNL206C	YNL206C	RTT106	hom	Verified	0.208136136487047	0.417561336059704	no	1970	0.422705786541243	1392	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS|CHROMOSOME		Histone chaperone, involved in regulation of chromatin structure in both transcribed and silenced chromosomal regions; affects transcriptional elongation; has a role in regulation of Ty1 transposition	DNA replication-independent nucleosome assembly|negative regulation of transcription from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|DNA replication-dependent nucleosome assembly|heterochromatin assembly involved in chromatin silencing	double-stranded DNA binding|histone binding	nucleus
YIL105C	YIL105C	SLM1	hom	Verified	0.207292112523071	0.417890866834207	no	1971	0.400060997735605	1309	NA	FT	VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|SIGNALING|CYTOSKELETON ORGANIZATION	MITOCHONDRION|PLASMA MEMBRANE		Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm2p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; phosphorylated by the TORC2 complex; protein abundance increases in response to DNA replication stress; SLM1 has a paralog, SLM2, that arose from the whole genome duplication	eisosome assembly|TOR signaling cascade|regulation of cell growth|actin filament bundle assembly|endosomal transport|establishment or maintenance of actin cytoskeleton polarity|actin cytoskeleton organization	phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol binding|sphingolipid binding	eisosome|mitochondrion|membrane raft|plasma membrane|cytoplasm
YPR118W	YPR118W	MRI1	hom	Verified	0.207072297414164	0.417976698328955	no	1972	0.423190021394658	1387	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		5'-methylthioribose-1-phosphate isomerase; catalyzes the isomerization of 5-methylthioribose-1-phosphate to 5-methylthioribulose-1-phosphate in the methionine salvage pathway	L-methionine salvage from methylthioadenosine	S-methyl-5-thioribose-1-phosphate isomerase activity	nucleus|cytoplasm
YMR175W	YMR175W	SIP18	hom	Verified	0.206980352973709	0.418012601154677	no	1973	0.406251136106489	1353	NA					Phospholipid-binding hydrophilin; essential to overcome desiccation-rehydration process; expression is induced by osmotic stress	cellular response to water deprivation	phospholipid binding	cytoplasm
YEL013W	YEL013W	VAC8	hom	Verified	0.206968062922804	0.418017400273732	no	1974	0.410944082204402	1359	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS			Phosphorylated and palmitoylated vacuolar membrane protein that interacts with Atg13p, required for the cytoplasm-to-vacuole targeting (Cvt) pathway; interacts with Nvj1p to form nucleus-vacuole junctions	piecemeal microautophagy of nucleus|vacuole inheritance|CVT vesicle assembly|vacuole fusion, non-autophagic|macroautophagy|nucleus-vacuole junction assembly	protein anchor	fungal-type vacuole membrane|nucleus-vacuole junction|Myo2p-Vac17p-Vac8p transport complex
YNL215W	YNL215W	IES2	hom	Verified	0.206944981756988	0.418026413228113	no	1975	0.422143961338229	1396	NA	FT		NUCLEUS		Protein that associates with the INO80 chromatin remodeling complex; associates with the INO80 complex under low-salt conditions; essential for growth under anaerobic conditions; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	nucleus
YIL065C	YIL065C	FIS1	hom	Verified	0.206943948704025	0.418026816625521	no	1976	0.412780341796319	1355	NA	FT	MITOCHONDRION ORGANIZATION|PEROXISOME ORGANIZATION	MITOCHONDRION		Protein involved in mitochondrial membrane fission and peroxisome abundance; required for localization of Dnm1p and Mdv1p during mitochondrial division; mediates ethanol-induced apoptosis and ethanol-induced mitochondrial fragmentation	peroxisome fission|mitochondrial fission|chronological cell aging|peroxisome organization	molecular_function	mitochondrial outer membrane|mitochondrion|peroxisome
YGR135W	YGR135W	PRE9	hom	Verified	0.206411903478613	0.418234586702434	no	1977	0.421953510743455	1353	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS	ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION		Alpha 3 subunit of the 20S proteasome, the only nonessential 20S subunit; may be replaced by the alpha 4 subunit (Pre6p) under stress conditions to create a more active proteasomal isoform	proteasomal ubiquitin-dependent protein catabolic process|proteasome core complex assembly|proteasomal ubiquitin-independent protein catabolic process	molecular_function	mitochondrion|proteasome core complex, alpha-subunit complex|proteasome storage granule|nucleus|nuclear outer membrane-endoplasmic reticulum membrane network
YGL015C_p	YGL015C	YGL015C	hom	Uncharacterized	0.20575941176452	0.418489423731993	no	1978	0.411302245607887	1345	NA					Putative protein of unknown function; null mutants accumulate cargo in the Golgi	biological_process	molecular_function	cellular_component
YGR151C_d	YGR151C	YGR151C	hom	Dubious	0.205572853905874	0.41856229202537	no	1979	0.415824705792404	1367	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF RSR1/BUD1/YGR152C; relative distribution to the nucleus increases upon DNA replication stress	Unknown	Unknown	Unknown
YKL023W_p	YKL023W	YKL023W	hom	Uncharacterized	0.205496472512819	0.418592126910112	no	1980	0.417081124261961	1363	NA					Putative protein of unknown function, predicted by computational methods to be involved in mRNA degradation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	biological_process	molecular_function	cytoplasm
YGR063C	YGR063C	SPT4	hom	Verified	0.205128282220769	0.418735950111587	no	1981	0.45875075394302	1529	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|RNA LOCALIZATION|CHROMOSOME SEGREGATION|GENE SILENCING	NUCLEUS|CHROMOSOME		Component of the universally conserved Spt4/5 complex (DSIF complex); the complex has multiple roles in concert with RNA polymerases I and II, including regulation of transcription elongation, RNA processing, quality control, and transcription-coupled DNA repair; Spt4p also localizes to kinetochores and heterochromatin and affects chromosome dynamics and silencing; required for transcription through lengthy trinucleotide repeats in ORFs or non-protein coding regions	7-methylguanosine mRNA capping|chromosome segregation|chromatin organization|intracellular mRNA localization|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription, DNA-dependent|regulation of transcription-coupled nucleotide-excision repair|chromatin silencing|mRNA splicing, via spliceosome|Unknown	core RNA polymerase I binding transcription factor activity|core RNA polymerase II binding transcription factor activity|rDNA binding	DSIF complex|nuclear telomeric heterochromatin|rDNA heterochromatin|mating-type region heterochromatin|kinetochore
YGR200C	YGR200C	ELP2	hom	Verified	0.204357259743995	0.419037163567062	no	1982	0.425355556026825	1414	NA	FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|RNA PROCESSING	NUCLEUS		Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; target of Kluyveromyces lactis zymocin	regulation of transcription from RNA polymerase II promoter|protein urmylation|tRNA wobble uridine modification	molecular_function	Elongator holoenzyme complex|nucleus|cytoplasm
YMR097C	YMR097C	MTG1	hom	Verified	0.204243314423128	0.419081682335123	no	1983	0.427737047956474	1387	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Putative GTPase peripheral to the mitochondrial inner membrane, essential for respiratory competence, likely functions in assembly of the large ribosomal subunit, has homologs in plants and animals	mitochondrial translation	GTPase activity	mitochondrion|mitochondrial inner membrane
YBL042C	YBL042C	FUI1	hom	Verified	0.204106197761705	0.419135255586779	no	1984	0.457717328009192	1529	NA	FF|FT		PLASMA MEMBRANE		High affinity uridine permease, localizes to the plasma membrane; also mediates low but significant transport of the cytotoxic nucleoside analog 5-fluorouridine; not involved in uracil transport; relative distribution to the vacuole increases upon DNA replication stress	uridine transport|transmembrane transport	uridine transmembrane transporter activity	integral to membrane|plasma membrane
YLR266C	YLR266C	PDR8	hom	Verified	0.20332736847918	0.419439582668901	no	1985	0.406044856081449	1346	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Transcription factor; targets include ATP-binding cassette (ABC) transporters, major facilitator superfamily transporters, and other genes involved in the pleiotropic drug resistance (PDR) phenomenon; PDR8 has a paralog, YRR1, that arose from the whole genome duplication	positive regulation of transcription from RNA polymerase II promoter in response to stress	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|sequence-specific DNA binding	nucleus
YBL029W_p	YBL029W	YBL029W	hom	Uncharacterized	0.202136896262325	0.41990485206287	no	1986	0.427582224405044	1431	NA	FT		NUCLEUS		Non-essential protein of unknown function	biological_process	molecular_function	nucleus|cytoplasm
YDR505C	YDR505C	PSP1	hom	Verified	0.201830217641658	0.420024728694649	no	1987	0.416837980086721	1383	NA	FT		MITOCHONDRION		Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication	biological_process	molecular_function	mitochondrion|cytoplasm
YCR020W-B	YCR020W-B	HTL1	hom	Verified	0.201762761092253	0.420051097566901	no	1988	0.431723410142219	1431	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE	NUCLEUS	RSC COMPLEX	Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance	regulation of cell cycle|nucleosome disassembly|response to DNA damage stimulus|chromatin remodeling|transcription elongation from RNA polymerase II promoter	chromatin binding	RSC complex
YLR034C	YLR034C	SMF3	hom	Verified	0.201309271410091	0.420228376714154	no	1989	0.416955935072041	1385	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Putative divalent metal ion transporter involved in iron homeostasis; transcriptionally regulated by metal ions; member of the Nramp family of metal transport proteins; protein abundance increases in response to DNA replication stress	cellular iron ion homeostasis|iron ion transport	metal ion transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane
YKL222C	YKL222C	YKL222C	hom	Verified	0.199814135792155	0.420812972751921	no	1990	0.418639080731784	1375	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS|CYTOSKELETON		Protein of unknown function that may interact with ribosomes, based on co-purification experiments; similar to transcriptional regulators from the zinc cluster (binuclear cluster) family; null mutant is sensitive to caffeine	biological_process	sequence-specific DNA binding	ribosome|nucleus|mitotic spindle
YOR327C	YOR327C	SNC2	hom	Verified	0.199676657323728	0.420866735438359	no	1991	0.404816403755645	1314	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Vesicle membrane receptor protein (v-SNARE); involved in the fusion between Golgi-derived secretory vesicles with the plasma membrane; member of the synaptobrevin/VAMP family of R-type v-SNARE proteins; SNC2 has a paralog, SNC1, that arose from the whole genome duplication	endocytosis|exocytosis|Golgi to plasma membrane transport|vesicle fusion	SNAP receptor activity	SNARE complex|trans-Golgi network|endosome|transport vesicle membrane
YKL109W	YKL109W	HAP4	hom	Verified	0.198413630472997	0.4213607269331	no	1992	0.417848525482362	1390	NA	FT	TRANSCRIPTION FROM RNA POL II|OXIDATION-REDUCTION PROCESS|RESPONSE TO NUTRIENT LEVELS|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS		Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex	regulation of cellular respiration|carbon catabolite activation of transcription from RNA polymerase II promoter	RNA polymerase II activating transcription factor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II transcription factor binding transcription factor activity	CCAAT-binding factor complex
YBR027C_d	YBR027C	YBR027C	hom	Dubious	0.198372476154147	0.421376825181006	no	1993	0.382479027932705	1267	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YML035C	YML035C	AMD1	hom	Verified	0.197599334851786	0.421679277627282	no	1994	0.416550397968123	1390	NA	FT	NUCLEOTIDE METABOLISM			AMP deaminase; tetrameric enzyme that catalyzes the deamination of AMP to form IMP and ammonia; thought to be involved in regulation of intracellular purine (adenine, guanine, and inosine) nucleotide pools	guanine salvage|purine nucleotide metabolic process	AMP deaminase activity	cytoplasm
YLR281C_p	YLR281C	YLR281C	hom	Uncharacterized	0.197321565990045	0.421787951943432	no	1995	0.413502969006119	1378	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION	MITOCHONDRION		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR281C is not an essential gene	biological_process	molecular_function	mitochondrion
YBR299W	YBR299W	MAL32	hom	Verified	0.197243000583805	0.421818690961525	no	1996	0.420892476052937	1394	NA	FT	CARBOHYDRATE METABOLISM			Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL3 complex locus; functional in genomic reference strain S288C; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose	sucrose catabolic process|maltose catabolic process	sucrose alpha-glucosidase activity|alpha-glucosidase activity|maltose alpha-glucosidase activity	plasma membrane
YER011W	YER011W	TIR1	hom	Verified	0.196412108643752	0.422143809759048	no	1997	0.397099207609352	1317	NA					Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expression is downregulated at acidic pH and induced by cold shock and anaerobiosis; abundance is increased in cells cultured without shaking	response to stress	structural constituent of cell wall	fungal-type cell wall
YOR197W	YOR197W	MCA1	hom	Verified	0.196066173905451	0.422279185841516	no	1998	0.417583283839101	1361	NA	FT	PROTEOLYSIS	NUCLEUS		Ca2+-dependent cysteine protease; may cleave specific substrates during the stress response; regulates apoptosis upon H2O2 treatment; required for clearance of insoluble protein aggregates during normal growth; implicated in cell cycle dynamics; undergoes autocatalytic processing; similar to mammalian metacaspases, but exists as a monomer due to an extra pair of anti-parallel beta-strands that form a continuous beta-sheet, blocking potential dimerization	misfolded or incompletely synthesized protein catabolic process|apoptotic process	cysteine-type peptidase activity	nucleus
YDL159W-A_p	YDL159W-A	YDL159W-A	hom	Uncharacterized	0.195374191695065	0.422550009661954	no	1999	0.426029192506075	1377	NA					Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species	biological_process	molecular_function	cellular_component
YJL049W_p	YJL049W	YJL049W	hom	Uncharacterized	0.194840441197644	0.422758930730754	no	2000	0.384778401062397	1273	NA	FT	PROTEIN LOCALIZATION			Putative protein of unknown function; YJL049W is a non-essential gene	biological_process	molecular_function	cellular_component
YPR038W_d	YPR038W	IRC16	hom	Dubious	0.194334756109408	0.422956886458817	no	2001	0.415432585993466	1377	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene YPR037C; null mutant displays increased levels of spontaneous Rad52p foci	Unknown	Unknown	Unknown
YPL265W	YPL265W	DIP5	hom	Verified	0.194271155466512	0.422981784975383	no	2002	0.400693323694812	1344	NA	FT		PLASMA MEMBRANE		Dicarboxylic amino acid permease; mediates high-affinity and high-capacity transport of L-glutamate and L-aspartate; also a transporter for Gln, Asn, Ser, Ala, and Gly; relocalizes from plasma membrane to vacuole upon DNA replication stress	amino acid transport	amino acid transmembrane transporter activity	integral to membrane|plasma membrane
YHR079C-A	YHR079C-A	SAE3	hom	Verified	0.193994282552043	0.423090179363313	no	2003	0.416474745980915	1385	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Meiosis specific protein involved in DMC1-dependent meiotic recombination, forms heterodimer with Mei5p; proposed to be an assembly factor for Dmc1p	double-strand break repair|reciprocal meiotic recombination|meiotic DNA recombinase assembly	molecular_function	condensed nuclear chromosome
YNR069C	YNR069C	BSC5	hom	Verified	0.19387278814761	0.423137745665145	no	2004	0.422871963523743	1385	NA					Protein of unknown function; shows homology with N-terminal end of Bul1p; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; readthrough expression includes YNR068C and the locus for this readthrough is termed BUL3; Bul3p is involved in ubiquitin-mediated sorting of plasma membrane proteins; readthrough and shortened forms of Bul3p interact with Rsp5p differently in vitro	biological_process	molecular_function	cellular_component
YMR316C-A_p	YMR316C-A	YMR316C-A	hom	Uncharacterized	0.193870265232734	0.423138733423997	no	2005	0.426425259440697	1438	NA					Protein of unknown function; mRNA identified as translated by ribosome profiling data; overlaps the verified gene DIA1/YMR316W	biological_process	molecular_function	cellular_component
YDR323C	YDR323C	PEP7	hom	Verified	0.193703933898947	0.423203855690844	no	2006	0.440200384908485	1429	NA	FF|FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT			Multivalent adaptor protein that facilitates vesicle-mediated vacuolar protein sorting by ensuring high-fidelity vesicle docking and fusion, which are essential for targeting of vesicles to the endosome; required for vacuole inheritance	Golgi to vacuole transport|vacuole inheritance|vesicle fusion|vesicle docking involved in exocytosis|Golgi to endosome transport	phosphatidylinositol-3-phosphate binding	external side of endosome membrane|cytoplasm
YJL071W	YJL071W	ARG2	hom	Verified	0.1918867257229	0.423915467782494	no	2007	0.416631977643204	1379	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		Acetylglutamate synthase (glutamate N-acetyltransferase), mitochondrial enzyme that catalyzes the first step in the biosynthesis of the arginine precursor ornithine; forms a complex with Arg5,6p	arginine biosynthetic process|ornithine biosynthetic process	acetyl-CoA:L-glutamate N-acetyltransferase activity	mitochondrial matrix
YHR079C	YHR079C	IRE1	hom	Verified	0.191122313838877	0.424214882974411	no	2008	0.443833839081471	1484	NA	FF|FT	RNA PROCESSING|SIGNALING|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM		Serine-threonine kinase and endoribonuclease; transmembrane protein that mediates the unfolded protein response (UPR) by regulating Hac1p synthesis through HAC1 mRNA splicing; Kar2p binds inactive Ire1p and releases from it upon ER stress	endoplasmic reticulum unfolded protein response|fungal-type cell wall organization|inositol metabolic process|protein phosphorylation	unfolded protein binding|protein serine/threonine kinase activity|endoribonuclease activity|protein kinase activity|protein homodimerization activity	nucleus
YKR001C	YKR001C	VPS1	hom	Verified	0.191045756294502	0.424244872482329	no	2009	0.457782097437491	1500	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CELL DIVISION|NUCLEOTIDE METABOLISM|CYTOSKELETON ORGANIZATION|VACUOLAR TRANSPORT|PEROXISOME ORGANIZATION	MITOCHONDRION|CYTOSKELETON		Dynamin-like GTPase required for vacuolar sorting; also involved in actin cytoskeleton organization, endocytosis, late Golgi-retention of some proteins, regulation of peroxisome biogenesis	vacuolar transport|peroxisome fission|endocytosis|actin cytoskeleton organization|protein retention in Golgi apparatus|peroxisome organization|lipid tube assembly|protein targeting to vacuole	GTPase activity	mitochondrial outer membrane|fungal-type vacuole membrane|peroxisome|actin cortical patch
YIL124W	YIL124W	AYR1	hom	Verified	0.191011702986238	0.424258212157176	no	2010	0.426293738014854	1402	NA	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS	ENDOPLASMIC RETICULUM|MITOCHONDRION		NADPH-dependent 1-acyl dihydroxyacetone phosphate reductase found in lipid particles, ER, and mitochondrial outer membrane; involved in phosphatidic acid biosynthesis; required for spore germination; capable of metabolizing steroid hormones	phosphatidic acid biosynthetic process	acylglycerone-phosphate reductase activity	mitochondrial outer membrane|mitochondrion|integral to membrane|endoplasmic reticulum|lipid particle|cytoplasm
YOR268C_p	YOR268C	YOR268C	hom	Uncharacterized	0.190908038467299	0.424298821109216	no	2011	0.401862028291254	1311	NA					Putative protein of unknown function; sporulation is abnormal in homozygous diploid; YOR268C is not an essential gene	biological_process	molecular_function	cellular_component
YNL130C-A_p	YNL130C-A	DGR1	hom	Uncharacterized	0.19072826317098	0.424369247171632	no	2012	0.417617379967508	1358	NA	FT		MITOCHONDRION		Protein of unknown function; dgr1 null mutant is resistant to 2-deoxy-D-glucose	biological_process	molecular_function	cellular_component
YDR385W	YDR385W	EFT2	hom	Verified	0.189668835333706	0.424784321638708	no	2013	0.422217389894613	1398	NA	FT	TRANSLATION|NUCLEOTIDE METABOLISM		RIBOSOME	Elongation factor 2 (EF-2), also encoded by EFT1; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin; EFT2 has a paralog, EFT1, that arose from the whole genome duplication	translational elongation|positive regulation of translational elongation	translation elongation factor activity	ribosome
YGL042C_d	YGL042C	YGL042C	hom	Dubious	0.189578888792358	0.424819565746863	no	2014	0.425928735026645	1418	NA					Dubious open reading frame, not conserved in closely related Saccharomyces species; deletion mutation blocks replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene DST1	Unknown	Unknown	Unknown
YGL004C	YGL004C	RPN14	hom	Verified	0.189575128153432	0.424821039305941	no	2015	0.442918570140277	1473	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS	NUCLEUS		Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasome regulatory particle (RP); null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; interacts with Rpt5p	proteasome regulatory particle assembly|ubiquitin-dependent protein catabolic process	molecular_function	cytosol|nucleus|cytoplasm
YOR192C	YOR192C	THI72	hom	Verified	0.18849284387171	0.425245162369755	no	2016	0.447233839060869	1476	NA					Transporter of thiamine or related compound; shares sequence similarity with Thi7p	thiamine transport	transporter activity	integral to membrane|membrane
YPR012W_d	YPR012W	YPR012W	hom	Dubious	0.186493487420674	0.42602889277926	no	2017	0.427835220662137	1417	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPR012W is not an essential gene	Unknown	Unknown	Unknown
YER113C	YER113C	TMN3	hom	Verified	0.18630142911686	0.426104193405451	no	2018	0.427659368881295	1421	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Protein with a role in cellular adhesion and filamentous growth; similar to Emp70p and Tmn2p; member of Transmembrane Nine family with 9 transmembrane segments; localizes to Golgi; induced by 8-methoxypsoralen plus UVA irradiation	cellular copper ion homeostasis|vacuolar transport|pseudohyphal growth|invasive growth in response to glucose limitation	molecular_function	COPI-coated vesicle|integral to membrane|Golgi apparatus
YPR147C_p	YPR147C	YPR147C	hom	Uncharacterized	0.186023992746647	0.426212973112028	no	2019	0.425793666245789	1424	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS	biological_process	molecular_function	cytoplasm
YOL028C	YOL028C	YAP7	hom	Verified	0.185642861143803	0.426362419715174	no	2020	0.430750757644526	1419	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Putative basic leucine zipper (bZIP) transcription factor; YAP7 has a paralog, YAP5, that arose from the whole genome duplication	positive regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding	nucleus
YGR210C_p	YGR210C	YGR210C	hom	Uncharacterized	0.185487773589599	0.426423234567791	no	2021	0.417972092749141	1354	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	biological_process	molecular_function	cytoplasm
YBL096C_d	YBL096C	YBL096C	hom	Dubious	0.185299839753414	0.426496931855688	no	2022	0.422466157489394	1399	NA					Non-essential protein of unknown function	Unknown	Unknown	Unknown
YOR014W	YOR014W	RTS1	hom	Verified	0.184716465948988	0.426725715231717	no	2023	0.429679105928535	1431	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|SIGNALING|CHROMOSOME SEGREGATION	NUCLEUS|SITE OF POLARIZED GROWTH|CHROMOSOME|CYTOSKELETON		B-type regulatory subunit of protein phosphatase 2A (PP2A); Rts1p and Cdc55p are alternative regulatory subunits for PP2A catalytic subunits, Pph21p and Pph22p; PP2A-Rts1p protects cohesin when recruited by Sgo1p to the pericentromere; highly enriched at centromeres in the absence of Cdc55p; required for maintenance of septin ring organization during cytokinesis, for ring disassembly in G1 and for dephosphorylation of septin, Shs1p; homolog of the mammalian B' subunit of PP2A	mitotic cell cycle spindle orientation checkpoint|cellular protein localization|meiotic sister chromatid cohesion, centromeric|protein dephosphorylation	protein serine/threonine phosphatase activity	nucleus|spindle pole body|condensed nuclear chromosome, centromeric region|cellular bud neck|cytoplasm
YHR138C	YHR138C	YHR138C	hom	Verified	0.184369767216413	0.426861692751726	no	2024	0.432482299521892	1404	NA	FT	MEMBRANE ORGANIZATION			Protein of unknown function; similar to Pbi2p; double null mutant lacking Pbi2p and Yhr138cp exhibits highly fragmented vacuoles; protein abundance increases in response to DNA replication stress	vacuole fusion, non-autophagic	endopeptidase inhibitor activity	cellular_component
YDL045W-A	YDL045W-A	MRP10	hom	Verified	0.184094447711949	0.426969681062394	no	2025	0.439965949048725	1466	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the small subunit; contains twin cysteine-x9-cysteine motifs	mitochondrial translation|mitochondrial respiratory chain complex assembly	structural constituent of ribosome	mitochondrial small ribosomal subunit
YBR300C_d	YBR300C	YBR300C	hom	Dubious	0.183536008680094	0.42718873388145	no	2026	0.413672670328607	1365	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR301W; YBR300C is not an essential gene	Unknown	Unknown	Unknown
YNL097C-B_p	YNL097C-B	YNL097C-B	hom	Uncharacterized	0.182801050167922	0.42747706229104	no	2027	0.412373011668456	1374	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YLR271W_p	YLR271W	YLR271W	hom	Uncharacterized	0.182657431009747	0.42753340943411	no	2028	0.410967584458226	1340	NA	FT		NUCLEUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS	biological_process	molecular_function	nucleus|cytoplasm
YGR004W	YGR004W	PEX31	hom	Verified	0.182651211110566	0.427535849765545	no	2029	0.396641917022506	1294	NA	FT	PEROXISOME ORGANIZATION			Peroxisomal integral membrane protein, involved in negative regulation of peroxisome size; partially functionally redundant with Pex30p and Pex32p; probably acts at a step downstream of steps mediated by Pex28p and Pex29p	peroxisome organization	molecular_function	integral to membrane|integral to peroxisomal membrane
YHL022C	YHL022C	SPO11	hom	Verified	0.18192244190279	0.427821796141425	no	2030	0.395527154199969	1290	NA	FT	CELL CYCLE	NUCLEUS|CHROMOSOME		Meiosis-specific protein that initiates meiotic recombination by catalyzing the formation of double-strand breaks in DNA via a transesterification reaction; required for homologous chromosome pairing and synaptonemal complex formation	meiotic DNA double-strand break formation	endodeoxyribonuclease activity, producing 3'-phosphomonoesters	nuclear chromosome
YPL200W	YPL200W	CSM4	hom	Verified	0.181838277034636	0.427854822263463	no	2031	0.439754656737721	1445	NA	FT	CELL CYCLE|CHROMOSOME SEGREGATION	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|CHROMOSOME		Protein required for accurate chromosome segregation during meiosis; involved in meiotic telomere clustering (bouquet formation) and telomere-led rapid prophase movements	meiotic telomere clustering|meiotic chromosome segregation|synapsis|regulation of reciprocal meiotic recombination	molecular_function	nuclear chromosome, telomeric region|endoplasmic reticulum membrane
YNR027W	YNR027W	BUD17	hom	Verified	0.181542426099714	0.427970917574497	no	2032	0.434469029209332	1461	NA	FT	CELL CYCLE|CELL DIVISION|COFACTOR METABOLISM	NUCLEUS		Putative pyridoxal kinase, a key enzyme in vitamin B6 metabolism; involved in bud-site selection; diploid mutants display a random rather than a bipolar budding pattern; similarity to yeast BUD16 and human pyridoxal kinase (PDXK)	pyridoxal phosphate biosynthetic process|cellular bud site selection	pyridoxal kinase activity	nucleus|cytoplasm
YDR444W_p	YDR444W	YDR444W	hom	Uncharacterized	0.181092959786514	0.428147305256999	no	2033	0.430111604481374	1407	NA	FT	LIPID METABOLISM			Putative hydrolase acting on ester bonds	biological_process	molecular_function	cytoplasm
YJR049C	YJR049C	UTR1	hom	Verified	0.180804185342255	0.428260638913925	no	2034	0.440785849887723	1459	NA	FF|FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS|COFACTOR METABOLISM	NUCLEUS		ATP-NADH kinase; phosphorylates both NAD and NADH; active as a hexamer; enhances the activity of ferric reductase (Fre1p); UTR1 has a paralog, YEF1, that arose from the whole genome duplication	cellular iron ion homeostasis|NADP biosynthetic process	NAD+ kinase activity|NADH kinase activity	nucleus|cytoplasm
YMR165C	YMR165C	PAH1	hom	Verified	0.180718323370457	0.428294337813349	no	2035	0.420247270555876	1387	NA	FT	LIPID METABOLISM|MEMBRANE ORGANIZATION|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM		Mg2+-dependent phosphatidate (PA) phosphatase; dephosphorylates PA to yield diacylglycerol; responsible for de novo lipid synthesis and formation of lipid droplets; phosphorylation by Pho80p-Pho85p decreases catalytic activity and alters Pah1p localization and abundance; phosphorylation by protein kinase A decreases catalytic efficiency; dephosphorylation by Nem1p-Spo7p anchors Pah1p to the membrane increasing substrate catalysis; homologous to mammalian lipins 1 and 2	plasmid maintenance|vacuole fusion, non-autophagic|lipid particle organization|aerobic respiration|phospholipid biosynthetic process	phosphatidate phosphatase activity	cytosol|nuclear membrane|vacuole|cytoplasm|extrinsic to membrane
YGL256W	YGL256W	ADH4	hom	Verified	0.180586833739398	0.428345945559801	no	2036	0.423982653787017	1390	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Alcohol dehydrogenase isoenzyme type IV, dimeric enzyme demonstrated to be zinc-dependent despite sequence similarity to iron-activated alcohol dehydrogenases; transcription is induced in response to zinc deficiency	fermentation|amino acid catabolic process to alcohol via Ehrlich pathway	alcohol dehydrogenase (NAD) activity	mitochondrion
YMR106C	YMR106C	YKU80	hom	Verified	0.180446267193068	0.428401117217256	no	2037	0.424536425586748	1406	NA	FT	PROTEIN LOCALIZATION|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING	NUCLEUS|CHROMOSOME		Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair	chromatin assembly or disassembly|protein localization to chromosome|chromatin silencing|double-strand break repair via nonhomologous end joining|donor selection|telomere maintenance|double-strand break repair via homologous recombination	damaged DNA binding|RNA binding|DNA binding|telomeric DNA binding	nuclear chromatin|nuclear telomeric heterochromatin|Ku70:Ku80 complex
YHR132W-A	YHR132W-A	IGO2	hom	Verified	0.180243527634297	0.428480693931684	no	2038	0.429586285067714	1416	NA	FT		NUCLEUS		Protein required for initiation of G0 program; prevents degradation of nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway; phosphorylated by Rim15p; GFP protein localizes to the cytoplasm and nucleus; similar to Igo1p	mRNA stabilization	molecular_function	nucleus|cytoplasm
YFR048W	YFR048W	RMD8	hom	Verified	0.178448968134479	0.429185197689552	no	2039	0.424160284355093	1387	NA	FT	CELL CYCLE			Cytosolic protein required for sporulation	biological_process	molecular_function	cytoplasm
YMR182C	YMR182C	RGM1	hom	Verified	0.177705321692404	0.42947720283378	no	2040	0.428832542241329	1438	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS|CHROMOSOME		Putative zinc finger DNA binding transcription factor; contains two N-terminal C2H2 zinc fingers and C-terminal proline rich domain; overproduction impairs cell growth and induces expression of genes involved in monosaccharide catabolism and aldehyde metabolism; regulates expression of of Y-prime telomeric elements and subtelomeric COS genes; RGM1 has a paralog, USV1, that arose from the whole genome duplication	positive regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity	nuclear chromatin
YOR246C	YOR246C	ENV9	hom	Verified	0.17756650942119	0.429531714059679	no	2041	0.432246641665083	1431	NA	FF|FT	OXIDATION-REDUCTION PROCESS|VACUOLAR PROTEIN PROCESSING			Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and defects in vacuolar morphology; has similarity to oxidoreductases, found in lipid particles; required for replication of Brome mosaic virus in S. cerevisiae, a model system for studying replication of positive-strand RNA viruses in their natural hosts	vacuole organization|vacuolar protein processing	oxidoreductase activity	lipid particle
YKL081W	YKL081W	TEF4	hom	Verified	0.177362961380775	0.429611649286887	no	2042	0.436142420785858	1432	NA	FT	TRANSLATION	MITOCHONDRION	RIBOSOME	Gamma subunit of translational elongation factor eEF1B, stimulates the binding of aminoacyl-tRNA (AA-tRNA) to ribosomes by releasing eEF1A (Tef1p/Tef2p) from the ribosomal complex	translational elongation	translation elongation factor activity	mitochondrion|ribosome|eukaryotic translation elongation factor 1 complex
YLR191W	YLR191W	PEX13	hom	Verified	0.176938943374922	0.429778174403828	no	2043	0.432673310242045	1454	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|PEROXISOME ORGANIZATION			Integral peroxisomal membrane protein required for translocation of peroxisomal matrix proteins, interacts with the PTS1 signal recognition factor Pex5p and the PTS2 signal recognition factor Pex7p, forms a complex with Pex14p and Pex17p	protein import into peroxisome matrix, docking	protein binding, bridging	peroxisomal membrane
YDR241W_d	YDR241W	BUD26	hom	Dubious	0.176442863813308	0.429973016202318	no	2044	0.4317755055795	1443	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 1% of ORF overlaps the verified gene SNU56; diploid mutant displays a weak budding pattern phenotype in a systematic assay	Unknown	Unknown	Unknown
YMR027W_p	YMR027W	YMR027W	hom	Uncharacterized	0.176196654795966	0.430069724380804	no	2045	0.423527081877626	1425	NA	FT		NUCLEUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; YMR027W is not an essential gene	biological_process	molecular_function	nucleus|cytoplasm
YBL061C	YBL061C	SKT5	hom	Verified	0.175567038015343	0.430317049956383	no	2046	0.434257929024703	1445	NA	FT	CELL WALL ORG/BIOGENESIS|CELL DIVISION|CARBOHYDRATE METABOLISM	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON		Activator of Chs3p (chitin synthase III) during vegetative growth; recruits Chs3p to the bud neck via interaction with Bni4p; SKT5 has a paralog, SHC1, that arose from the whole genome duplication	fungal-type cell wall chitin biosynthetic process|response to osmotic stress|cytokinesis	enzyme activator activity	incipient cellular bud site|cellular bud neck septin ring|cellular bud neck
YAL049C	YAL049C	AIM2	hom	Verified	0.174319623758537	0.430807138910027	no	2047	0.430724419856456	1426	NA					Cytoplasmic protein involved in mitochondrial function or organization; null mutant displays reduced frequency of mitochondrial genome loss; potential Hsp82p interactor	biological_process	molecular_function	cytoplasm
YGR192C	YGR192C	TDH3	hom	Verified	0.173433694602092	0.431155270965422	no	2048	0.434636368958658	1427	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Glyceraldehyde-3-phosphate dehydrogenase, isozyme 3; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; TDH3 has a paralog, TDH2, that arose from the whole genome duplication	gluconeogenesis|reactive oxygen species metabolic process|glycolysis|apoptotic process	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity	mitochondrion|fungal-type cell wall|lipid particle|plasma membrane|cytoplasm
YKR106W	YKR106W	GEX2	hom	Verified	0.173337643139254	0.431193018278273	no	2049	0.419799823954933	1375	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Proton:glutathione antiporter localized to the vacuolar and plasma membranes; expressed at a very low level; almost identical to paralog Gex1p; potential role in resistance to oxidative stress and modulation of the PKA pathway	glutathione transmembrane transport	solute:hydrogen antiporter activity	integral to membrane|plasma membrane|vacuolar membrane
YJR105W	YJR105W	ADO1	hom	Verified	0.173051997628987	0.43130527796378	no	2050	0.450493715003391	1477	NA	FF|FT	NUCLEOTIDE METABOLISM	NUCLEUS		Adenosine kinase, required for the utilization of S-adenosylmethionine (AdoMet); may be involved in recycling adenosine produced through the methyl cycle	purine nucleobase metabolic process	adenosine kinase activity	nucleus|cytoplasm
YHL045W_d	YHL045W	YHL045W	hom	Dubious	0.172352519991288	0.43158019853844	no	2051	0.429026490875093	1407	NA					Putative protein of unknown function; not an essential gene	Unknown	Unknown	Unknown
YHR039C	YHR039C	MSC7	hom	Verified	0.172194697564937	0.431642233175095	no	2052	0.440783193812362	1471	NA	FT	CELL CYCLE|OXIDATION-REDUCTION PROCESS	ENDOPLASMIC RETICULUM		Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; msc7 mutants are defective in directing meiotic recombination events to homologous chromatids	reciprocal meiotic recombination	molecular_function	integral to membrane|endoplasmic reticulum
YKL162C-A_d	YKL162C-A	YKL162C-A	hom	Dubious	0.171945587231209	0.431740153418352	no	2053	0.42991432510497	1426	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YIL157C	YIL157C	COA1	hom	Verified	0.171900701335277	0.431757797604044	no	2054	0.438693067712573	1430	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial inner membrane protein required for assembly of the cytochrome c oxidase complex (complex IV); interacts with complex IV assembly factor Shy1p during the early stages of assembly	mitochondrial respiratory chain complex IV assembly	molecular_function	integral to mitochondrial membrane|mitochondrion|integral to mitochondrial inner membrane
YGL203C	YGL203C	KEX1	hom	Verified	0.171541328435054	0.431899068313765	no	2055	0.435776045838814	1442	NA	FT	PROTEOLYSIS	GOLGI APPARATUS		Protease involved in the processing of killer toxin and alpha factor precursor; cleaves Lys and Arg residues from the C-terminus of peptides and proteins	protein processing	serine-type carboxypeptidase activity	trans-Golgi network
YJL063C	YJL063C	MRPL8	hom	Verified	0.171426136380234	0.431944352546485	no	2056	0.438720199953384	1479	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit	mitochondrial genome maintenance|mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YIL046W-A_p	YIL046W-A	YIL046W-A	hom	Uncharacterized	0.171340302777167	0.431978095983395	no	2057	0.430589197532938	1407	NA					Putative protein of unknown function; identified by expression profiling and mass spectrometry	biological_process	molecular_function	cellular_component
YOR080W	YOR080W	DIA2	hom	Verified	0.171312182581142	0.431989150876711	no	2058	0.436819699450711	1451	NA	FT	CELL CYCLE|PROTEOLYSIS	NUCLEUS|CHROMOSOME	UBIQUITIN LIGASE COMPLEX	Origin-binding F-box protein; forms an SCF ubiquitin ligase complex with Skp1p and Cdc53p; plays a role in DNA replication; plays a role in transcription; required for correct assembly of RSC complex, correct RSC-mediated transcription regulation, and correct nucleosome positioning; involved in invasive and pseudohyphal growth; required to target Cdc6p for ubiquitin-mediated destruction during G1 phase	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|regulation of DNA replication|invasive growth in response to glucose limitation|protein ubiquitination	ubiquitin-protein ligase activity|DNA replication origin binding	SCF ubiquitin ligase complex|nucleus|nuclear replication fork
YOL007C	YOL007C	CSI2	hom	Verified	0.171099661079959	0.432072701180948	no	2059	0.426324863383985	1415	NA	FT		SITE OF POLARIZED GROWTH		Protein of unknown function; green fluorescent protein (GFP)- fusion protein localizes to the mother side of the bud neck and the vacuole; YOL007C is not an essential gene	biological_process	molecular_function	fungal-type vacuole|cellular bud neck
YGL006W	YGL006W	PMC1	hom	Verified	0.170600031575158	0.432269136547747	no	2060	0.42966845562569	1414	NA	FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS			Vacuolar Ca2+ ATPase involved in depleting cytosol of Ca2+ ions; prevents growth inhibition by activation of calcineurin in the presence of elevated concentrations of calcium; similar to mammalian PMCA1a	cellular calcium ion homeostasis|calcium ion transport|transmembrane transport	calcium-transporting ATPase activity	fungal-type vacuole membrane|integral to membrane
YNR030W	YNR030W	ALG12	hom	Verified	0.170355171245305	0.432365412456985	no	2061	0.459066694715202	1526	NA	FT	LIPID METABOLISM|CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Alpha-1,6-mannosyltransferase localized to the ER; responsible for the addition of the alpha-1,6 mannose to dolichol-linked Man7GlcNAc2, acts in the dolichol pathway for N-glycosylation	dolichol-linked oligosaccharide biosynthetic process|protein glycosylation	alpha-1,6-mannosyltransferase activity	integral to membrane|endoplasmic reticulum
YIL006W	YIL006W	YIA6	hom	Verified	0.169874801067106	0.43255429944977	no	2062	0.443565264375488	1465	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Mitochondrial NAD+ transporter, involved in the transport of NAD+ into the mitochondria (see also YEA6); member of the mitochondrial carrier subfamily; disputed role as a pyruvate transporter; has putative mouse and human orthologs	transport|mitochondrial pyruvate transport|NAD transmembrane transport	pyruvate secondary active transmembrane transporter activity|transporter activity|NAD transporter activity	mitochondrion|integral to membrane|mitochondrial inner membrane
YDL239C	YDL239C	ADY3	hom	Verified	0.169819940181425	0.43257587235267	no	2063	0.43854059777514	1428	NA	FT	CELL CYCLE|CELL WALL ORG/BIOGENESIS|CELL DIVISION|MITOCHONDRION ORGANIZATION	NUCLEUS|CYTOSKELETON		Protein required for spore wall formation; thought to mediate assembly of a Don1p-containing structure at the leading edge of the prospore membrane via interaction with spindle pole body components; potentially phosphorylated by Cdc28p; ADY3 has a paralog, CNM67, that arose from the whole genome duplication	mitochondrion inheritance|ascospore wall assembly|sporulation resulting in formation of a cellular spore	molecular_function	spindle pole body|prospore membrane
YHR097C_p	YHR097C	YHR097C	hom	Uncharacterized	0.169264803045855	0.432794179787488	no	2064	0.425666169058425	1405	NA	FT		NUCLEUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus	biological_process	molecular_function	nucleus|cytoplasm
YOL141W	YOL141W	PPM2	hom	Verified	0.168771052418505	0.432988364243938	no	2065	0.405984019698396	1338	NA	FT	RNA PROCESSING	MITOCHONDRION		AdoMet-dependent tRNA methyltransferase also involved in methoxycarbonylation; required for the synthesis of wybutosine (yW), a modified guanosine found at the 3'-position adjacent to the anticodon of phe-tRNA; similarity to Ppm1p	tRNA methylation|wybutosine biosynthetic process	tRNA methyltransferase activity	mitochondrion|cytoplasm
YBL047C	YBL047C	EDE1	hom	Verified	0.168325062316639	0.433163779138422	no	2066	0.37050263140447	1246	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING	SITE OF POLARIZED GROWTH|CYTOSKELETON		Endocytic protein; involved in a network of interactions with other endocytic proteins, binds membranes in a ubiquitin-dependent manner, may also bind ubiquitinated membrane-associated proteins; interacts with Cmk2 and functions upstream of CMK2 in regulating non-apoptotic cell death	endoplasmic reticulum unfolded protein response|endocytosis	ubiquitin binding	cellular bud neck|mating projection tip|actin cortical patch|cellular bud tip
YLR366W_d	YLR366W	YLR366W	hom	Dubious	0.168248465689578	0.433193907117929	no	2067	0.426479448416914	1431	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR364C-A	Unknown	Unknown	Unknown
YLR285W	YLR285W	NNT1	hom	Verified	0.167896451911028	0.433332370735834	no	2068	0.426953480266473	1403	NA	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|GENE SILENCING			S-adenosylmethionine-dependent methyltransferase; has a role in rDNA silencing and in lifespan determination	chromatin silencing at rDNA|nicotinamide metabolic process	S-adenosylmethionine-dependent methyltransferase activity|nicotinamide N-methyltransferase activity	cytoplasm
YLR352W_p	YLR352W	YLR352W	hom	Uncharacterized	0.167833807340579	0.433357012657579	no	2069	0.441910915544913	1447	NA					Putative protein of unknown function with similarity to F-box proteins; interacts with Skp1p and Cdc53p; YLR352W is not an essential gene	biological_process	molecular_function	SCF ubiquitin ligase complex
YMR120C	YMR120C	ADE17	hom	Verified	0.16762060377973	0.433440880533203	no	2070	0.406352279092395	1342	NA	FT	NUCLEOTIDE METABOLISM			Enzyme of 'de novo' purine biosynthesis; contains both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities; ADE17 has a paralog, ADE16, that arose from the whole genome duplication; ade16 ade17 mutants require adenine and histidine	purine nucleotide biosynthetic process|'de novo' IMP biosynthetic process	phosphoribosylaminoimidazolecarboxamide formyltransferase activity|IMP cyclohydrolase activity	cytosol|plasma membrane
YBR047W_p	YBR047W	FMP23	hom	Uncharacterized	0.166983063991757	0.433691687399538	no	2071	0.431496534655765	1439	NA	FT		MITOCHONDRION		Putative protein of unknown function; proposed to be involved in iron or copper homeostasis; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YLR024C	YLR024C	UBR2	hom	Verified	0.165311946587991	0.434349228085944	no	2072	0.423398701315695	1396	NA					Cytoplasmic ubiquitin-protein ligase (E3); required for ubiquitylation of Rpn4p; mediates formation of a Mub1p-Ubr2p-Rad6p complex	protein monoubiquitination	ubiquitin-protein ligase activity	cytoplasm
YER061C	YER061C	CEM1	hom	Verified	0.163823029470083	0.434935230855682	no	2073	0.446126855091652	1464	NA	FT	KETONE METABOLISM|LIPID METABOLISM	MITOCHONDRION		Mitochondrial beta-keto-acyl synthase with possible role in fatty acid synthesis; required for mitochondrial respiration	fatty acid biosynthetic process	fatty acid synthase activity	mitochondrion
YKR103W	YKR103W	NFT1	hom	Verified	0.163424511294572	0.435092102543828	no	2074	0.442362324124585	1453	NA	FT	NUCLEOTIDE METABOLISM			Putative transporter of the multidrug resistance-associated protein (MRP) subfamily; adjacent ORFs YKR103W and YKR104W are merged in different strain backgrounds.	transport	ATPase activity, coupled to transmembrane movement of substances	integral to membrane|membrane
YDR488C	YDR488C	PAC11	hom	Verified	0.163407915439612	0.435098635516026	no	2075	0.404958494242862	1337	NA	FT		CYTOSKELETON		Dynein intermediate chain, acts in the cytoplasmic dynein pathway, forms cortical cytoplasmic microtubule capture site with Num1p; null mutant is defective in nuclear migration, essential in the absence of CIN8	nuclear migration along microtubule|microtubule-based process	plus-end-directed microtubule motor activity|microtubule motor activity	cytoplasmic dynein complex|cytoplasmic microtubule
YHR184W	YHR184W	SSP1	hom	Verified	0.162697203520834	0.435378424460135	no	2076	0.438417048287525	1481	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL WALL ORG/BIOGENESIS|CELL DIVISION			Protein involved in the control of meiotic nuclear division and coordination of meiosis with spore formation; transcription is induced midway through meiosis	ascospore wall assembly|protein complex assembly	molecular_function	prospore membrane
YBR212W	YBR212W	NGR1	hom	Verified	0.161667972870048	0.435783663327416	no	2077	0.445358588078156	1477	NA	FT	MITOCHONDRION ORGANIZATION			RNA binding protein that negatively regulates growth rate; interacts with the 3' UTR of the mitochondrial porin (POR1) mRNA and enhances its degradation; overexpression impairs mitochondrial function; interacts with Dhh1p to mediate POR1 mRNA decay; expressed in stationary phase	3'-UTR-mediated mRNA destabilization|mitochondrion organization	mRNA binding	cytoplasmic mRNA processing body|cytoplasmic stress granule|perinuclear region of cytoplasm|cytoplasm
YMR017W	YMR017W	SPO20	hom	Verified	0.161519905079622	0.435841967600048	no	2078	0.417861701764834	1388	NA	FT		PLASMA MEMBRANE		Meiosis-specific subunit of the t-SNARE complex, required for prospore membrane formation during sporulation; similar to but not functionally redundant with Sec9p; SNAP-25 homolog	ascospore-type prospore assembly	SNAP receptor activity	SNARE complex|prospore membrane
YBR014C	YBR014C	GRX7	hom	Verified	0.161324701052876	0.435918834717824	no	2079	0.421300892684592	1399	NA	FT	RESPONSE TO OXIDATIVE STRESS	GOLGI APPARATUS		Cis-golgi localized monothiol glutaredoxin; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; does not bind metal ions; GRX7 has a paralog, GRX6, that arose from the whole genome duplication	cellular response to oxidative stress	glutathione-disulfide reductase activity|protein homodimerization activity	integral to membrane|Golgi apparatus|Golgi lumen|fungal-type vacuole|cis-Golgi network
YPL114W_d	YPL114W	YPL114W	hom	Dubious	0.161006168489919	0.436044271138528	no	2080	0.426009455417707	1425	NA					Dubious open reading frame, unlikely to encode a functional protein; largely overlaps ORF YPL113C; diploid deletion in BY4743 strain background exhibits high budding index	Unknown	Unknown	Unknown
YOR205C	YOR205C	GEP3	hom	Verified	0.160771595606952	0.436136648799915	no	2081	0.42044573807024	1404	NA	FT		MITOCHONDRION		Protein required for mitochondrial ribosome small subunit biogenesis; null mutant is defective in respiration and in maturation of 15S rRNA; protein is localized to the mitochondrial inner membrane; null mutant interacts synthetically with prohibitin (phb1)	maturation of SSU-rRNA	molecular_function	mitochondrion|mitochondrial inner membrane
YJL126W	YJL126W	NIT2	hom	Verified	0.159729406548546	0.436547117613824	no	2082	0.442202739296715	1473	NA					Nit protein, one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member	biological_process	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	cellular_component
YAL056W	YAL056W	GPB2	hom	Verified	0.159675127580831	0.436568497399406	no	2083	0.437507917080943	1469	NA	FT	TRANSCRIPTION FROM RNA POL II|SIGNALING	MITOCHONDRION|PLASMA MEMBRANE		Multistep regulator of cAMP-PKA signaling; inhibits PKA downstream of Gpa2p and Cyr1p, thereby increasing cAMP dependency; inhibits Ras activity through direct interactions with Ira1p/2p; regulated by G-alpha protein Gpa2p; GPB2 has a paralog, GPB1, that arose from the whole genome duplication	signal transduction|glucose mediated signaling pathway|pseudohyphal growth|ascospore formation|negative regulation of Ras protein signal transduction|invasive growth in response to glucose limitation|positive regulation of transcription from RNA polymerase II promoter	cAMP-dependent protein kinase inhibitor activity|signal transducer activity|GTPase activating protein binding	mitochondrion|plasma membrane|cytoplasm
YLR016C	YLR016C	PML1	hom	Verified	0.159627039588055	0.436587438794582	no	2084	0.417407921618406	1365	NA	FT	RNA PROCESSING|RNA LOCALIZATION	NUCLEUS		Subunit of the RES complex, which is required for nuclear retention of unspliced pre-mRNAs; acts in the same pathway as Pml39p and Mlp1p	mRNA export from nucleus|mRNA splicing, via spliceosome|maintenance of RNA location	molecular_function	RES complex|nucleus|cytoplasm
YLL040C	YLL040C	VPS13	hom	Verified	0.159267768532667	0.436728956785989	no	2085	0.419280857872796	1395	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT	MITOCHONDRION|GOLGI APPARATUS		Protein of unknown function; heterooligomeric or homooligomeric complex; peripherally associated with membranes; involved in sporulation, vacuolar protein sorting, prospore membrane formation and protein-Golgi retention; homologous to human CHAC and COH1 which are involved in chorea acanthocytosis and Cohen syndrome, respectively	protein retention in Golgi apparatus|late endosome to vacuole transport|protein targeting to vacuole|ascospore-type prospore membrane assembly	molecular_function	endosome|mitochondrion|prospore membrane|extrinsic to membrane
YDR205W	YDR205W	MSC2	hom	Verified	0.159115917957483	0.436788773637776	no	2086	0.433658908549815	1430	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM		Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids	cellular zinc ion homeostasis|zinc ion transport|transmembrane transport	zinc ion transmembrane transporter activity|metal ion transmembrane transporter activity	integral to membrane|endoplasmic reticulum
YDR306C_p	YDR306C	YDR306C	hom	Uncharacterized	0.159075622815995	0.436804646908971	no	2087	0.444107974929847	1477	NA	FT	PROTEOLYSIS			F-box protein of unknown function; interacts with Sgt1p via a Leucine-Rich Repeat (LRR) domain	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	ubiquitin-protein ligase activity|protein binding, bridging	SCF ubiquitin ligase complex
YGL002W	YGL002W	ERP6	hom	Verified	0.159004899743958	0.436832506754424	no	2088	0.458258611433738	1516	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION		Member of the p24 family involved in ER to Golgi transport; similar to Emp24p and Erv25p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; ERP6 has a paralog, ERP1, that arose from the whole genome duplication	ER to Golgi vesicle-mediated transport	molecular_function	mitochondrion|integral to membrane
YOR052C	YOR052C	YOR052C	hom	Verified	0.158923611563143	0.436864528886073	no	2089	0.440525543299314	1446	NA