SGTCid condition conc unit MTW1|YAL034W-A.score MTW1|YAL034W-A.strain.pval MTW1|YAL034W-A.strain.significant MTW1|YAL034W-A.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_1524 corynanthine 62.1 µM 8.4463850707217 2.28250552883863e-21 yes 1 1.50230751821836e-17 1 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_408 cantharidin 100 µM 6.53062415176945 1.66148160537378e-13 yes 2 3.27480848494343e-11 3 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_147 4466-0538 29.23 µM 4.57834180595221 1.68284537347301e-07 yes 3 2.34338204747219e-06 3 6742687 YHR072W ERG7
SGTC_153 4077-0274 519.67 µM 4.33347219898235 6.88054994316269e-07 yes 4 7.33879116444247e-06 5 3121976
SGTC_2583 asiatic acid 100 µM 4.25989713180458 1.03576112964109e-06 yes 5 1.02260504597092e-05 6 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_3064 1327-0027 10 µM 4.02788932029798 3.60520466338404e-06 yes 6 2.81399124461636e-05 5 16000455 YPR107C YTH1
SGTC_1394 3474-0001 65.7 µM 3.82827855208611 1.00130051999728e-05 yes 7 6.45213317227017e-05 5 5017666 YIL048W NEO1
SGTC_398 bronopol 33.3 µM 3.80256141559153 1.13819858813622e-05 yes 8 7.16038748482547e-05 11 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_2533 agelasine 13.65 µM 3.69563822952314 1.92281094458188e-05 yes 9 0.000109667553032642 16 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_985 1493-0307 8.71 µM 3.55788751141094 3.70341478181398e-05 yes 10 0.000186924669651666 4 3278274
SGTC_2692 st077426 47.7 µM 3.52097920116607 4.39756408963823e-05 yes 11 0.000214978169764951 9 25238571
SGTC_1611 st001856 99.4 µM 3.25001127081596 0.000147750887477362 yes 12 0.000577002173782383 20 647478
SGTC_33 0986-0033 35.816 µM 3.22489905914034 0.000164589142774039 yes 13 0.000630085460452001 5 2848082
SGTC_3189 9110682 49.47 µM 3.2208199614995 0.000167488206835395 yes 14 0.000639122099688885 14 17122418
SGTC_1903 st060211 78.3 µM 3.10800294983896 0.00026936641432518 yes 15 0.00094178094021486 7 688960
SGTC_1901 st060216 58.6 µM 2.99515970665218 0.000426836633247552 yes 16 0.00137150589688276 10 688792
SGTC_412 gemfibrozil 100 µM 2.96800587322921 0.000475775772663668 yes 17 0.00149869301599507 21 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_402 epigallocatechin gallate 10 µM 2.9254764737096 0.000562968242685812 yes 18 0.00171964590102021 20 65064 An antioxidant.
SGTC_1576 erythromycin ethylsuccinate 23.2 µM 2.91842830659821 0.000578770946139876 yes 19 0.00175900381457717 13 3256 An antibiotic and ribosome inhibitor.
SGTC_155 k072-0202 43.6 µM 2.87459868312114 0.000686604903655009 yes 20 0.00202270664539355 18 5857737
SGTC_1287 0971-0001 34.6 µM 2.85613834239678 0.00073734005546975 yes 21 0.00214414119766718 18 4665869
SGTC_1384 3089-0840 101 µM 2.85118684819416 0.000751524173876371 yes 22 0.00217781830602629 6 1069836
SGTC_384 k007-0144 5.16 µM 2.84169063239199 0.00077943286368883 yes 23 0.00224375071184964 40 6824886
SGTC_1173 0443-0020 122 µM 2.76726680899153 0.00103349792478051 no 24 0.00282642351838242 18 5331295
SGTC_190 3970-0790 3.722 µM 2.76333725409846 0.00104882137082624 no 25 0.00286068081288471 10 2832352
SGTC_900 1112-0045 141 µM 2.74925395606827 0.00110546722132468 no 26 0.00298655439560813 17 56211 YIL048W NEO1
SGTC_426 0988-0037 14.6 µM 2.73905503789974 0.00114822505762605 no 27 0.00308080288040426 28 5383008
SGTC_1811 st050069 61.5 µM 2.73683276352446 0.00115774042677085 no 28 0.00310169100602995 8 3877702
SGTC_987 1497-1013 404 µM 2.72484624732445 0.00121032131642518 no 29 0.00321657186345047 17 1676435
SGTC_3298 9116858 71.43 µM 2.70367371277299 0.0013085678122114 no 30 0.00342887960856093 20 2506942
SGTC_1464 k208-0027 110 µM 2.70021801887152 0.00132527839568237 no 31 0.0034647025111749 18 X1464
SGTC_751 0833-0568 350 µM 2.70019872306176 0.00132537224891403 no 32 0.00346490347844988 15 6954252
SGTC_1263 0774-1208 64.8 µM 2.68338131088761 0.00140951973265641 no 33 0.00364409198960001 24 906585
SGTC_2629 bisabolol 100 µM 2.68178208418531 0.00141777044853939 no 34 0.00366155727685245 32 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_110 0850-0284 111.64 µM 2.67983117947969 0.00142789523931769 no 35 0.00368296493777152 10 3906265
SGTC_2771 fluoxetine 41.05 µM 2.6777466574048 0.00143878639006822 no 36 0.0037059628269633 16 3386 A selective serotonin reuptake inhibitor.
SGTC_2130 NSC 7 2.4545 µM 2.66371347051888 0.00151410234358597 no 37 0.00386416796707033 18 21448
SGTC_2958 9077254 16.72 µM 2.64373817161877 0.00162752020536945 no 38 0.00409980279936065 23 16457351
SGTC_1262 0737-0114 49.6 µM 2.63339991732721 0.00168921120002395 no 39 0.004226737275745 20 765919
SGTC_1908 st060353 56.5 µM 2.56170852276682 0.00217899425077205 no 40 0.00520793466524157 34 4227716
SGTC_2180 6301957 200 µM 2.55990851328261 0.0021928008419655 no 41 0.00523498607976862 30 845462
SGTC_542 3381-0244 89.3 µM 2.55188999991564 0.00225527357234494 no 42 0.00535701695663027 32 1112843
SGTC_352 k048-0007 5.11 µM 2.51868110787608 0.00253153491233179 no 43 0.0058897643506852 47 6811911
SGTC_450 aminopyrene 156 nM 2.51274637724658 0.002584011076205 no 44 0.00598977117122076 27 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_549 1661-1316 519 µM 2.46333217371269 0.00306057572408008 no 45 0.00688261606167523 35 2857282
SGTC_2571 chrysanthemic acid 100 µM 2.45722533847721 0.00312466308761608 no 46 0.00700074154683064 27 2743 An insecticide.
SGTC_2815 7968870 71.43 µM 2.42141546399425 0.0035253739676183 no 47 0.00773009822393786 28 2977326 YHR190W ERG9
SGTC_2415 st077333 57.7 µM 2.40783749767072 0.00368899138675808 no 48 0.00802366105329786 56 2766255
SGTC_1628 st004252 77.7 µM 2.40686443203938 0.00370097456627832 no 49 0.00804507074824732 26 692968
SGTC_1678 st019265 80.2 µM 2.37662335864616 0.00409123154320136 no 50 0.00873595908842045 30 5367020
SGTC_425 3825-7017 13.1 µM 2.37258187813354 0.00414608484811492 no 51 0.00883212377370718 42 3397440
SGTC_1118 chelidonine 707.474 nM 2.36676999295926 0.00422612070798106 no 52 0.00897204032890329 21 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_534 k292-0788 63.4 µM 2.35729504132706 0.00435956642224211 no 53 0.00920430712980206 47 4146317
SGTC_1179 1021-1431 9.29 µM 2.3164921721812 0.00497825996479381 no 54 0.010265705673076 32 2840958
SGTC_965 1291-5240 308 µM 2.29775170417091 0.0052877697684733 no 55 0.0107879624795685 36 2834598
SGTC_3209 9113616 49.47 µM 2.28722834595518 0.00546897245039793 no 56 0.0110912491612296 40 16649353
SGTC_1574 spiramycin 23.7 µM 2.28586622159454 0.00549282587550373 no 57 0.0111310430496458 41 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_31 0508-1974 57.237 µM 2.26182874768479 0.00592924998220623 no 58 0.0118539929866312 24 6810525
SGTC_2337 9009472 200 µM 2.23950626320929 0.00636179242179818 no 59 0.0125614971285461 44 5742383
SGTC_1273 0849-0096 14.1 µM 2.23623022478272 0.00642756829381755 no 60 0.0126683471620168 40 5286025
SGTC_3136 9095672 49.47 µM 2.23243044246357 0.00650461296956155 no 61 0.0127932638361736 37 17217380
SGTC_535 2293-4129 48.2 µM 2.19144438947545 0.00738902172367376 no 62 0.0142098249183895 56 396118 YIL048W NEO1
SGTC_1779 st039427 55 µM 2.18250562890251 0.00759542448769202 no 63 0.014536118141822 38 1124498
SGTC_1409 3909-8004 61.9 µM 2.17849847083322 0.00768958938836127 no 64 0.0146844729774415 37 2119279
SGTC_2568 diosmetin 100 µM 2.17490077974443 0.00777500605625932 no 65 0.0148187762415485 57 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_249 wiskostatin 11.211 µM 2.16627140932263 0.00798329654007908 no 66 0.0151452265735542 29 2775510 A n-wasp and actin depolymerizer.
SGTC_348 k064-0012 10.7 µM 2.16537279616601 0.00800526624930344 no 67 0.0151795738091675 58 5066323
SGTC_1047 2043-3044 82 µM 2.16094282373041 0.00811435095650547 no 68 0.0153498781813459 54 669592
SGTC_416 estradiol valerate 100 µM 2.15752047332907 0.00819951599829446 no 69 0.0154825668363228 38 13791 A steroid.
SGTC_3329 9141233 27.5565 µM 2.14408985487652 0.0085413706830877 no 70 0.0160128438993048 41 4909101 YNL103W MET4
SGTC_724 3910-0327 137 µM 2.13649063324677 0.00874028446006124 no 71 0.016319721821938 50 2885483
SGTC_568 1193-0097 7.48 µM 2.13605435928796 0.00875182645316526 no 72 0.0163374916470045 73 3646150
SGTC_3146 9095609 49.47 µM 2.13592791291721 0.00875517419459216 no 73 0.0163426450159971 31 17173999
SGTC_491 tetrandrine 80.3 µM 2.13584186258251 0.00875745306932647 no 74 0.0163461528254433 36 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_3063 1327-0034 4 µM 2.13033163470981 0.00890446774126186 no 75 0.0165721217927109 42 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_1690 st023502 41.2 µM 2.12689609692589 0.00899721956248286 no 76 0.0167143586192508 38 24207482
SGTC_2860 9025725 38.96 µM 2.1194737045798 0.00920050133965281 no 77 0.0170252268604204 41 40546248
SGTC_296 1222-0039 74.9 µM 2.09931595457655 0.00977298865076309 no 78 0.0178945289581149 34 5984176
SGTC_2489 cantharidin 73.42 µM 2.07820118617533 0.0104057875512072 no 79 0.0188454164508704 62 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1379 2144-0755 36.5 µM 2.0762618208689 0.0104656616950325 no 80 0.0189348711787507 44 5392327
SGTC_453 enantio-paf c16 10 µM 2.0754141963514 0.0104919246045462 no 81 0.0189740817975805 72 13871343 A lipid and platelet activating factor
SGTC_749 1000-0129 128 µM 2.06362685779288 0.0108631411500176 no 82 0.01952655453988 39 708470
SGTC_1905 st060207 84.5 µM 2.06078894373932 0.0109542041467074 no 83 0.0196615898658996 47 1948547
SGTC_414 piperonyl butoxide 100 µM 2.05529049109112 0.0111325300042984 no 84 0.0199254776092991 44 5794 A potent inhibitor of cytochrome P450.
SGTC_1454 4239-0054 42.6 µM 2.05160955784965 0.0112533159568075 no 85 0.0201038112850822 51 1340767
SGTC_2181 6316240 54.2555 µM 2.04533762938264 0.0114617477532421 no 86 0.0204107916631724 41 12779990
SGTC_2182 6325192 200 µM 2.04199298580242 0.0115742635208143 no 87 0.0205761135522847 36 736248
SGTC_3289 9119912 71.43 µM 2.02878597221808 0.0120279772540858 no 88 0.0212400473494873 51 17014829
SGTC_2237 6667747 47.222 µM 2.02422368482401 0.0121882546751103 no 89 0.0214735708342961 43 729940 YDL015C TSC13
SGTC_1878 temozolomide 1 mM 2.02369736298673 0.0122068634073327 no 90 0.0215006500445709 38 5394 DNA alkylating agent.
SGTC_3168 9103419 49.47 µM 2.00818646910666 0.0127664340415805 no 91 0.0223117401597053 28 16649256
SGTC_1312 1218-2183 165 µM 2.00537461690384 0.0128702160429426 no 92 0.0224615066099377 49 6744073
SGTC_2179 6298986 200 µM 1.9816612035435 0.0137748464483782 no 93 0.0237585860741766 51 738374
SGTC_1414 3917-0015 5.4 µM 1.98035700782223 0.0138261525665978 no 94 0.0238317136083185 37 6618702
SGTC_3162 9099653 49.47 µM 1.97502122368189 0.0140377785205824 no 95 0.0241328697683686 33 25237511
SGTC_189 3970-0742 2.116 µM 1.96685513574721 0.0143670635012364 no 96 0.0245999570168526 37 2891807
SGTC_533 1222-0222 6.71 µM 1.94574768396561 0.0152491604652154 no 97 0.0258425278502305 59 3982874
SGTC_65 0798-0905 34.986 µM 1.93923062889715 0.0155307457273002 no 98 0.0262366308080299 68 3602145
SGTC_2709 st078560 56 µM 1.93642150167808 0.0156534905252308 no 99 0.0264080490721466 62 17250903
SGTC_1091 telmisartan 47.6 µM 1.93582743110174 0.0156795547900537 no 100 0.0264444200323718 52 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_932 2857-0803 154 µM 1.93328921886153 0.0157913361639746 no 101 0.0266002895943584 52 674898
SGTC_632 0781-2353 4.65 µM 1.91805427232597 0.0164767371935575 no 102 0.0275520649191573 97 6811515 YHR007C ERG11
SGTC_747 3448-8087 38.7 µM 1.91725489888437 0.0165133925851003 no 103 0.027602778320707 52 5168703
SGTC_3042 9091578 49.47 µM 1.91677553575913 0.0165354073173384 no 104 0.0276332271096433 38 25236497
SGTC_3328 9140624 29.0385 µM 1.91361038070794 0.0166813983935236 no 105 0.0278349788371116 56 4904392
SGTC_2187 6125751 200 µM 1.90888851508418 0.0169012410834362 no 106 0.028138237454751 65 874498
SGTC_378 3970-0959 8.33 µM 1.88544526114958 0.018029760380123 no 107 0.0296848740882881 59 6615653
SGTC_1861 st057647 17.4 µM 1.8837974131137 0.0181114467900106 no 108 0.0297961918086611 53 688668
SGTC_2644 guaiazulene 100 µM 1.88205646971589 0.0181980905737263 no 109 0.029914174423628 32 3515 A coloring agent.
SGTC_2255 7941087 197.44 µM 1.88086389210529 0.0182576467806985 no 110 0.0299952180586865 58 935561
SGTC_725 1497-0963 19 µM 1.87769912882195 0.0184164977800835 no 111 0.0302111679865428 52 3549977
SGTC_1689 st020265 53.493 µM 1.87484305753249 0.0185608634431229 no 112 0.0304071588416102 58 5758320 YPR016C TIF6
SGTC_3193 9111931 49.47 µM 1.87045034702902 0.0187847816244857 no 113 0.030710653007872 53 17087244
SGTC_1900 st060200 72.8 µM 1.86337538188455 0.0191502591883615 no 114 0.0312047355657867 61 688945
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 1.85779504610091 0.0194427756785935 no 115 0.031599062450336 62 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_294 k038-0071 157 µM 1.85531928913584 0.0195737633363854 no 116 0.0317753226492295 76 24152826
SGTC_639 0833-0042 114 µM 1.85464150474407 0.0196097540370485 no 117 0.0318237185254548 72 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_133 0724-0033 378.92 µM 1.8455679217604 0.0200970027959466 no 118 0.0324774839147522 67 280309
SGTC_2135 5326629 150.42 µM 1.83429977647915 0.0207163573144529 no 119 0.0333047536673256 60 5020077
SGTC_2807 7945238 51.95 µM 1.80848366626561 0.0221965069643958 no 120 0.0352656283516724 61 17148797
SGTC_936 3005-4620 401 µM 1.80379038554136 0.0224749616460084 no 121 0.0356320868204525 67 777207
SGTC_608 k048-0125 159 µM 1.80224467300942 0.0225673119905889 no 122 0.035753459505558 57 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_1256 0570-0116 285 µM 1.7952936618513 0.0229865717419545 no 123 0.0363034621723402 76 410638
SGTC_135 0933-0004 26.348 µM 1.79496368604614 0.0230066367214471 no 124 0.0363297429381323 70 21230617 YGL099W LSG1
SGTC_2281 7943571 200 µM 1.7908366188847 0.0232588415460969 no 125 0.0366597585174313 71 1244024
SGTC_286 k060-0067 22.9 µM 1.78403637624069 0.0236794790741248 no 126 0.0372088772303941 77 5985051
SGTC_2532 xanthone 78.9 µM 1.78027928379013 0.0239146098118707 no 127 0.0375151328568991 48 7020 An insecticide.
SGTC_2683 piperine 63.03 µM 1.77651016808807 0.0241524616206486 no 128 0.037824433740809 66 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_3236 9132701 49.47 µM 1.77624796956128 0.0241690814484908 no 129 0.0378460274520822 62 24282524
SGTC_1234 0326-0494 15.5 µM 1.77509237749923 0.024242444810967 no 130 0.0379413176931756 79 1547813
SGTC_2479 5617353 43.85 µM 1.76183522071348 0.0250975439671139 no 131 0.0390485710361968 75 2731746
SGTC_1586 deoxycorticosterone acetate 53.7 µM 1.75970695736322 0.0252371466814967 no 132 0.039228752783157 57 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 1.75813590572769 0.0253406162220698 no 133 0.0393621938437411 60 6312947
SGTC_1636 st007707 68.9 µM 1.75515366405457 0.0255380044718334 no 134 0.0396165135917116 62 403051
SGTC_1915 st067105 30.6 µM 1.74843287020264 0.0259875631298332 no 135 0.0401945501372251 98 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_1315 1237-0019 3.69 µM 1.74613199625603 0.0261429834374688 no 136 0.0403940090522607 65 825140
SGTC_1716 st033144 30.6155 µM 1.74107496714609 0.0264873104315121 no 137 0.0408352193147161 72 674617
SGTC_1808 st050063 61.5 µM 1.73800085133748 0.0266984692839215 no 138 0.041105331883269 61 4011993
SGTC_1304 1165-0502 251 µM 1.73374185312584 0.0269933385268075 no 139 0.0414819484338637 76 767425
SGTC_3149 9097855 49.47 µM 1.72183474316346 0.0278321745171862 no 140 0.0425497294627764 62 25236625 YMR079W SEC14
SGTC_2053 5265679 138 µM 1.72156426545594 0.0278514786754656 no 141 0.0425742405747338 79 764595
SGTC_2104 5389443 200 µM 1.72116312362944 0.027880128949052 no 142 0.0426106136948075 80 2244536
SGTC_2299 7976368 114.88 µM 1.72104683652979 0.0278884389724037 no 143 0.0426211626035936 68 2979718
SGTC_1238 0333-0287 48.8 µM 1.71020425812013 0.0286723783182782 no 144 0.0436140542931849 51 7226
SGTC_326 k292-0812 17.5 µM 1.70440743737624 0.0290989628222692 no 145 0.044152497711146 66 3579357
SGTC_1733 st037357 54.9 µM 1.69354728451604 0.0299123492439185 no 146 0.0451756712308456 86 1272339 YGL099W LSG1
SGTC_1853 st056710 91.2 µM 1.68896023757334 0.0302615225121758 no 147 0.0456135250831 82 269167
SGTC_593 1203-0218 61.7 µM 1.68728737200166 0.0303897014262037 no 148 0.0457740539910907 84 3666956
SGTC_1663 st014140 55.4 µM 1.68584539345551 0.0305005499316996 no 149 0.0459127909814165 62 4207120
SGTC_571 k831-0106 44.2 µM 1.68244700917936 0.0307631175471069 no 150 0.0462410961347842 81 4783639
SGTC_637 1181-0519 7.26 µM 1.68112094909585 0.0308660785463819 no 151 0.0463697120299905 90 6252091 YGR060W ERG25
SGTC_2711 st079103 59.1 µM 1.68067691511857 0.0309006189339586 no 152 0.0464128434596037 57 54693780
SGTC_1071 trifluoperazine 6.31 µM 1.66301300081573 0.0323008205939732 no 153 0.0481549165580845 77 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_992 3909-8734 162 µM 1.64898514970211 0.0334497402421003 no 154 0.0495753385464549 74 4288319
SGTC_284 0988-0104 32.6 µM 1.64743102813389 0.0335790721641267 no 155 0.049734741045563 76 4666532
SGTC_492 tmb-8 126 µM 1.6449923949721 0.033782841376505 no 156 0.0499856897046218 56 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_600 1495-0418 41.6 µM 1.64132618183252 0.0340910991924037 no 157 0.0503648620206958 98 5377768
SGTC_2957 9076800 11.52 µM 1.63672097626111 0.0344815814183671 no 158 0.0508443919927564 68 16459615
SGTC_1618 st003135 44.5 µM 1.63579738644982 0.0345603346799114 no 159 0.0509409996028958 78 1270615
SGTC_382 3229-0966 23.2 µM 1.6321291211789 0.0348745828038036 no 160 0.0513261441060344 81 5722370
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 1.62795318286949 0.0352351727442351 no 161 0.0517674066115493 80 7104
SGTC_1332 1480-0653 17.5 µM 1.61909132531322 0.0360105246098568 no 162 0.0527138074918413 85 5749438
SGTC_722 3534-0461 190 µM 1.61008147248545 0.0368130957012689 no 163 0.0536900356212854 63 658262
SGTC_2025 5147754 141 µM 1.6004180019453 0.0376900853953955 no 164 0.0547529420773506 64 315777 YLR208W SEC13
SGTC_3107 9121808 49.47 µM 1.59425950023764 0.0382578335153042 no 165 0.0554389623459845 61 662681
SGTC_2536 dehydroabietamide 32.04 µM 1.59115879723497 0.0385463137485923 no 166 0.0557869214675078 66 3983547
SGTC_1597 7-benzyloxygramine 47.5 µM 1.58142181740948 0.039463755550443 no 167 0.0568908111054836 129 260807
SGTC_2808 7946468 45.46 µM 1.57289775005097 0.0402814236491194 no 168 0.0578712480888291 98 2970879
SGTC_1979 st071809 45.3 µM 1.56962070457048 0.0405994123129596 no 169 0.058251689380056 86 4976333
SGTC_2487 5918373 44.05 µM 1.56488661969911 0.0410623798199602 no 170 0.0588047482900765 108 2876279
SGTC_1692 fluoroquinolonic acid 71 µM 1.5630691479208 0.0412412520451947 no 171 0.0590181657037912 68 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_988 1497-1057 103 µM 1.56097003727997 0.0414486281794329 no 172 0.0592654103104526 88 3533044
SGTC_3161 9100388 49.47 µM 1.56054162845477 0.0414910553608369 no 173 0.0593159702741381 86 25236368
SGTC_3314 9135860 59.4275 µM 1.559256930848 0.0416184955532559 no 174 0.0594677905352094 75 25252478
SGTC_3110 9122132 49.47 µM 1.55691757890401 0.0418513702869737 no 175 0.0597450276273541 68 918317
SGTC_864 0469-0573 172 µM 1.55514414279606 0.0420286121752783 no 176 0.0599558719134984 90 689425
SGTC_1587 estradiol valerate 56.1 µM 1.55120799372563 0.0424241724127144 no 177 0.0604259235530601 104 13791 A steroid.
SGTC_2254 7938975 95.19 µM 1.55110531201417 0.0424345314947225 no 178 0.0604382242018773 89 2969277
SGTC_1034 k072-0165 12.7 µM 1.54690919733842 0.042859611113508 no 179 0.060942571470006 99 5835461
SGTC_2555 cholic acid 100 µM 1.53775035956829 0.0437993854011232 no 180 0.0620548326059534 64 6708657 Influences liver metabolism.
SGTC_2791 5663188 71.43 µM 1.53757966143327 0.0438170570179145 no 181 0.062075711761739 119 54690634
SGTC_1229 0139-0193 12.2 µM 1.53577456086901 0.044004283249196 no 182 0.0622968404790277 116 3090752
SGTC_1976 st070609 63.5 µM 1.52830365548124 0.0447860413819167 no 183 0.0632185813740829 83 682556
SGTC_1572 epiandrosterone 68.9 µM 1.52711510748509 0.044911436324745 no 184 0.063366195444841 88 441302 A steroid.
SGTC_2829 7992743 58.44 µM 1.51309048285407 0.0464125161064978 no 185 0.0651283383731282 78 16462845
SGTC_297 0986-0032 24 µM 1.51082658288242 0.0466585581411143 no 186 0.0654163200036191 103 2847425
SGTC_2602 kawain 100 µM 1.50558410609033 0.047232332142138 no 187 0.0660869855564843 104 5369129
SGTC_3313 9133968 57.047 µM 1.50437738523324 0.0473652017459547 no 188 0.0662421119063798 81 1494643
SGTC_1807 st050092 58.9 µM 1.50157873115203 0.0476745088430548 no 189 0.0666029698061029 100 5008496
SGTC_2106 5357045 167.29 µM 1.50011553977222 0.0478368634448351 no 190 0.0667922381320554 101 668842
SGTC_997 3996-0078 137 µM 1.49808829028607 0.0480625366922524 no 191 0.0670551565076142 107 735687
SGTC_210 3551-0445 56.827 µM 1.49715993842735 0.0481661647725596 no 192 0.0671758233448247 90 2865180 YOR207C RET1
SGTC_222 nsc-310342 10.666 µM 1.49677050693056 0.0482096885932358 no 193 0.0672264914696288 75 432556
SGTC_1540 guanosine 70.6 µM 1.48021538367174 0.0500892111307002 no 194 0.0694078881280225 78 6802 Guanosine is a purine nucleoside
SGTC_3333 9141820 12.094 µM 1.4799128349558 0.0501240958126587 no 195 0.0694482549777337 97 1939433
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 1.47663856650763 0.0505028681235817 no 196 0.0698862739482392 117 688803
SGTC_2213 7173844 200 µM 1.47165332621937 0.0510839434210076 no 197 0.0705572587116841 96 892728
SGTC_876 0720-0963 56.8 µM 1.46871429406189 0.0514289997579954 no 198 0.0709551493840535 95 765861
SGTC_2030 5175110 200 µM 1.4673878084266 0.0515853413915141 no 199 0.0711352945406509 90 2831986
SGTC_359 0081-0058 15.9 µM 1.46734022576685 0.0515909565698862 no 200 0.0711417630862491 109 3494159
SGTC_1871 st057448 67.3 µM 1.46634699455687 0.0517082776982737 no 201 0.071276889387054 99 691747
SGTC_109 0132-0036 33.701 µM 1.46590194043194 0.0517609165468652 no 202 0.0713375016300934 92 67274 A color developer.
SGTC_634 1611-4317 11.2 µM 1.46503946665727 0.0518630470146861 no 203 0.071455075175149 113 2843522
SGTC_2435 5706476 10.6 µM 1.46282387648141 0.0521261419378075 no 204 0.0717577889807434 89 5725375
SGTC_2437 5741531 144.16 µM 1.46081916236498 0.0523651084980142 no 205 0.0720325378077892 122 2262990
SGTC_655 k060-0012 42 µM 1.46017552066884 0.0524420162719344 no 206 0.0721209206132953 114 5994525
SGTC_1487 3970-0795 2.82 µM 1.45386698395716 0.0532005688929041 no 207 0.0729915939762982 110 3765103
SGTC_830 4076-0286 57.8 µM 1.45109773208264 0.0535362853671027 no 208 0.0733763239812776 106 6866659
SGTC_1348 1493-0373 93.8 µM 1.44770875827103 0.0539494121699713 no 209 0.0738492597359779 105 3010129
SGTC_806 3966-4455 5.86 µM 1.44707028797412 0.0540275255499558 no 210 0.0739386193132252 85 714982
SGTC_968 1309-0633 340 µM 1.44111325136287 0.0547606581887071 no 211 0.0747763452273889 106 3761976
SGTC_187 1488-2104 32.728 µM 1.44033033595573 0.0548575935705223 no 212 0.0748869813347927 90 2852859
SGTC_1603 st002045 67.8 µM 1.43780684576913 0.0551709586520251 no 213 0.0752444332189506 89 5887985
SGTC_1289 0976-0073 69.1 µM 1.43593616354606 0.0554041698686992 no 214 0.0755102534427902 100 3391136
SGTC_2429 5902844 64.44 µM 1.43572001022144 0.0554311670175721 no 215 0.0755410144630785 117 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_2367 9070478 135.38 µM 1.43191323585549 0.0559083303437786 no 216 0.0760843268955186 109 572802
SGTC_2021 4019055 173 µM 1.42949859992379 0.0562126705603109 no 217 0.076430488527761 151 44827708 YER133W GLC7
SGTC_2188 6126565 140.678 µM 1.42866132441352 0.0563185050638927 no 218 0.0765507995099033 90 874518
SGTC_2967 9089538 49.85 µM 1.42616088185013 0.056635504778633 no 219 0.0769109541622105 125 728216
SGTC_2754 granisetron 64.02 µM 1.42537395396748 0.056735559783164 no 220 0.0770245664578738 123 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_2262 9014885 67.46 µM 1.42516130550053 0.0567626211411327 no 221 0.0770552893476782 75 6457424
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 1.41961591797518 0.0574719156347802 no 222 0.0778597643399159 79 1241132 A phosphatase inhibitor.
SGTC_3259 9138485 49.47 µM 1.41783887931318 0.0577006808090779 no 223 0.0781189051206639 85 17646153
SGTC_1406 3909-7906 11.9 µM 1.412212744119 0.0584296797806156 no 224 0.0789436645836549 100 X1406
SGTC_80 0159-0065 512.242 µM 1.411732106281 0.0584922916336055 no 225 0.0790144280221982 63 1548079
SGTC_2693 st077581 40.7 µM 1.41073280224819 0.0586226378544706 no 226 0.0791617075097583 102 25238761
SGTC_288 1315-0019 35.1 µM 1.4104779191162 0.0586559205168616 no 227 0.0791993059611017 146 6811474
SGTC_1357 1503-1303 39.5 µM 1.4091347071395 0.0588315623799666 no 228 0.0793976699444916 109 292895
SGTC_1809 st050081 57.6 µM 1.40818179843002 0.0589564172516678 no 229 0.0795386222499159 111 5036894
SGTC_392 N-ethylmaleimide 8.33 µM 1.40616755678933 0.0592210173673104 no 230 0.0798371877657844 124 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_3157 9099274 49.47 µM 1.40559316712337 0.059296642253813 no 231 0.0799224830962663 101 17217662
SGTC_2716 st080858 38.6235 µM 1.40384466679261 0.0595273182217966 no 232 0.0801825548889519 98 5296050
SGTC_2461 5755302 26.15 µM 1.40272229387546 0.0596757607689237 no 233 0.0803498333162835 106 2788904
SGTC_1825 st052143 62.6 µM 1.40250102636839 0.0597050593157826 no 234 0.0803828421146461 102 674173
SGTC_2133 5320837 200 µM 1.39772226347783 0.0603405806578855 no 235 0.0810982429925038 81 2841355
SGTC_1430 4049-0248 69.1 µM 1.39676185606935 0.0604689405989346 no 236 0.081242598115397 116 22774488
SGTC_2746 daunorubicin 9.88 µM 1.39310518713454 0.0609596162832299 no 237 0.0817939923892472 63 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2027 5150920 200 µM 1.39220383568238 0.061081042410099 no 238 0.0819303408002022 95 786715
SGTC_2338 7999974 200 µM 1.3880494889361 0.0616431430540008 no 239 0.0825609879679469 125 315925
SGTC_485 niflumic acid 177 µM 1.38543380136872 0.0619991235159854 no 240 0.082959930672414 95 4488 A COX2 inhibitor.
SGTC_1026 k007-1105 30.6 µM 1.38419464082012 0.0621683253660646 no 241 0.0831494319496347 140 7066794
SGTC_1115 galangin 695.678 nM 1.38030833933257 0.0627013195945533 no 242 0.0837458642014231 118 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1922 5578187 25 µM 1.37718147981072 0.0631327386074041 no 243 0.0842280731402571 116 1350412
SGTC_186 3455-3465 67.277 µM 1.37672531889217 0.0631958687907542 no 244 0.0842985938753516 107 755278
SGTC_3002 9075603 71.4286 µM 1.37656991117702 0.0632173875934315 no 245 0.0843226294310973 122 20105405
SGTC_545 4218-0007 221 µM 1.37430958769198 0.0635310126100536 no 246 0.0846727955339481 123 2840508
SGTC_3226 9131256 49.47 µM 1.37045603114362 0.0640684925378606 no 247 0.0852722958521698 92 17178073
SGTC_1114 scopoletin 1.73284 µM 1.36986334618288 0.0641514708241435 no 248 0.0853647817047498 102 5280460 A coumarin with genotoxic properties.
SGTC_1421 4029-0249 71.4 µM 1.36876781982926 0.0643050688328956 no 249 0.0855359314955437 119 2894095
SGTC_1581 himbacine 57.9 µM 1.36766315360596 0.064460237531302 no 250 0.0857087692311778 105 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_1066 ketoconazole 628 nM 1.36650911354373 0.0646226521379091 no 251 0.0858896111782412 119 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_2884 9058502 51.95 µM 1.36591874943851 0.064705860226149 no 252 0.0859822335492577 107 6471554
SGTC_1815 st051655 58.2 µM 1.36452221926029 0.0649030235202366 no 253 0.0862016330004858 133 5984156
SGTC_906 1165-0455 526 µM 1.36393110134592 0.064986618394997 no 254 0.0862946255896145 113 3252859
SGTC_564 3555-0129 330 µM 1.36342323087785 0.0650585072872088 no 255 0.0863745818868067 103 563260
SGTC_2634 4'-methoxyflavone 100 µM 1.36158748445285 0.0653188713989258 no 256 0.0866640536081194 99 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_385 1494-0393 12.4 µM 1.36113746769529 0.0653828205229663 no 257 0.0867351255336174 119 3090647
SGTC_3100 9120536 49.47 µM 1.3603671074439 0.0654924044063051 no 258 0.0868568909476834 104 16421196
SGTC_376 3970-0862 59.1 µM 1.35950427788685 0.0656153111148138 no 259 0.0869934239171616 139 3135186
SGTC_1902 st060212 70.5 µM 1.35805254675751 0.0658225080454469 no 260 0.0872235055473502 112 688944
SGTC_1717 st033143 58.0435 µM 1.35488921950396 0.0662757469694005 no 261 0.0877264274372764 106 674616
SGTC_561 1550-0330 72.9 µM 1.35369688512897 0.0664472094997329 no 262 0.08791655115471 122 6812934
SGTC_2977 9011197 71.43 µM 1.35168300244832 0.0667375936728879 no 263 0.0882383724425219 121 2704722
SGTC_490 phenamil 164 µM 1.34995245737319 0.0669879066849984 no 264 0.0885156167267796 111 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_3330 9141424 71.43 µM 1.34696666193451 0.0674214906937748 no 265 0.0889954850058855 89 27261020
SGTC_1704 st028805 70.8 µM 1.34639036116659 0.0675054277218148 no 266 0.0890883289127532 128 2876101
SGTC_1345 1488-0192 31.4 µM 1.34379532284537 0.0678843905868091 no 267 0.0895072911876767 113 658348
SGTC_2008 4012253 172 µM 1.33974189683074 0.0684796116987879 no 268 0.0901646356951662 123 603940
SGTC_1555 citronellol 128 µM 1.33848736429388 0.0686646457867084 no 269 0.090368808317412 100 8842 A terpine precursor.
SGTC_702 1488-0190 94 µM 1.33213946174494 0.0696068304894884 no 270 0.0914071825759744 79 949357
SGTC_1011 4112-3381 17.4 µM 1.33183618685302 0.0696520918378522 no 271 0.0914570119831844 121 2877139
SGTC_2253 7938677 135.83 µM 1.32872819733079 0.0701172411772053 no 272 0.0919688293016627 98 2301972
SGTC_986 1493-0483 84 µM 1.32819875034416 0.0701967171640379 no 273 0.0920562285703686 118 40079
SGTC_1654 st012436 41.8 µM 1.32694213624293 0.0703856265320818 no 274 0.0922639122264276 93 4323132
SGTC_107 0358-0022 2.6945 µM 1.32195868862578 0.0711386491040152 no 275 0.093090953848537 110 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_2275 7947463 200 µM 1.32046927108673 0.0713649036792471 no 276 0.0933391945273294 124 1225414
SGTC_478 N-arachidonylglycine 10 µM 1.31948715047546 0.0715143976625325 no 277 0.0935031515572871 65 5283389
SGTC_415 dibenzyl ketone 100 µM 1.31835839812374 0.071686507937564 no 278 0.0936918501608371 128 7593
SGTC_1655 st012546 55.1 µM 1.3156771382969 0.0720966156956042 no 279 0.0941412153219461 101 720985 YLR208W SEC13
SGTC_785 1270-0111 65.3 µM 1.31385128776226 0.0723769134533487 no 280 0.0944481270894143 130 6741994
SGTC_3045 9092950 49.47 µM 1.31023846048384 0.0729340008809529 no 281 0.0950575892764806 95 44120432
SGTC_792 4534-1957 155 µM 1.30886918456266 0.0731459948656829 no 282 0.0952893332662569 107 1717904
SGTC_129 0088-0017 176.636 µM 1.305240561305 0.0737100656628244 no 283 0.0959054732736643 109 182446
SGTC_3103 9120822 49.47 µM 1.30483371547463 0.0737735167403564 no 284 0.0959747379339728 155 17141819
SGTC_940 3232-1287 54.8 µM 1.30201482072002 0.0742142946812571 no 285 0.0964556596205028 119 1585493 YIL048W NEO1
SGTC_635 k038-0028 24.7 µM 1.30108785597674 0.0743596786105285 no 286 0.0966141920349836 150 4035102
SGTC_1125 tnp00248 1.32998 µM 1.29811029285971 0.0748281470063993 no 287 0.0971247189418937 156 24207736
SGTC_676 falcarinol 140 µM 1.2951003554005 0.0753039941075551 no 288 0.0976428061691702 131 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_427 1354-0053 47.3 µM 1.29182949947169 0.0758237019109861 no 289 0.0982080984955335 108 6813657
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 1.28936585987132 0.0762169510330511 no 290 0.0986354622342044 125 756377
SGTC_2185 6113692 200 µM 1.28914747150395 0.0762518852076844 no 291 0.0986734113070498 126 874150
SGTC_1855 st056195 39.6 µM 1.28833181363022 0.0763824684778349 no 292 0.0988152416459258 116 4028379
SGTC_1045 1348-1485 165 µM 1.28685918448737 0.0766186608003294 no 293 0.0990716868612835 124 6810614
SGTC_1977 st070720 65.3 µM 1.28648289181393 0.0766791027125684 no 294 0.0991372928850785 101 682188
SGTC_164 4100-3994 89.624 µM 1.27895864634335 0.0778953073264175 no 295 0.100455809383002 146 4615967
SGTC_2125 5246583 200 µM 1.27226740291976 0.0789891150434817 no 296 0.101639063136996 147 835267
SGTC_3177 9107506 49.47 µM 1.27184735134829 0.0790581663823493 no 297 0.10171368055602 106 8897194
SGTC_219 mitoxanthrone 164.414 µM 1.26536911057861 0.0801289071421935 no 298 0.102869521417704 135 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_1793 st048256 72.231 µM 1.26447093176126 0.0802782217223065 no 299 0.103030523827721 118 672022
SGTC_1760 st045453 10.4495 µM 1.26402973732189 0.080351643508685 no 300 0.10310967682875 134 3323419 YIL048W NEO1
SGTC_1736 st036774 51 µM 1.26392980112548 0.0803682815308547 no 301 0.103127612131389 140 1272247
SGTC_457 grayanotoxin iii 135 µM 1.25836834709702 0.0812982971625798 no 302 0.104129286856384 152 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_686 1319-0111 510 µM 1.25703681516561 0.0815221628531011 no 303 0.104370152433117 139 4562600
SGTC_1418 3966-3099 2.4 µM 1.25669251771997 0.0815801239184018 no 304 0.104432499275418 152 740335
SGTC_3109 9122853 49.47 µM 1.25507553432171 0.0818527521639307 no 305 0.104725670487168 156 1234709
SGTC_2379 9035213 200 µM 1.25213114978863 0.0823509468868235 no 306 0.105261039413307 139 646551
SGTC_3153 9100258 49.47 µM 1.25174460020221 0.0824165209108943 no 307 0.105331471392133 129 25236848
SGTC_645 0845-0943 5.41 µM 1.24883755860496 0.0829109297116316 no 308 0.105862246806493 135 1885106
SGTC_1141 3253-0389 52.6 µM 1.24446543687717 0.0836587053772328 no 309 0.106664156196338 141 5402031
SGTC_2314 7727897 200 µM 1.24420553490034 0.083703316145908 no 310 0.106711963604757 107 900724
SGTC_3142 9086498 49.47 µM 1.24400466646758 0.0837378063674743 no 311 0.106748922739922 172 25236367
SGTC_1657 st012939 43.4 µM 1.24289221411565 0.0839290139035387 no 312 0.10695377758725 105 24207257
SGTC_3227 9130768 49.47 µM 1.24117454956629 0.0842248885659249 no 313 0.107270637227216 117 17720899
SGTC_505 gw-5074 63.9 µM 1.23964480234758 0.0844890521852933 no 314 0.107553400829635 136 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_2107 5363541 170.161 µM 1.23651176713315 0.0850320181569049 no 315 0.108134197247487 132 244052
SGTC_2475 5812728 15.03 µM 1.23360473979574 0.0855381514174957 no 316 0.108675112983954 139 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_468 gf-109203x 121 µM 1.23097006850772 0.0859988114852836 no 317 0.109167029588106 87 2396 A protein kinase C inhibitor.
SGTC_1895 st058434 18.3 µM 1.2262961554655 0.0868205870718646 no 318 0.110043623794696 153 5393175
SGTC_2186 6124449 200 µM 1.22475690173629 0.0870925016637398 no 319 0.110333413894381 141 3834182 YLR033W RSC58
SGTC_3061 glucosamine 200 µM 1.22360622494479 0.0872961878476158 no 320 0.110550405095935 116 91431 and experimental redox chemotherapeutic
SGTC_2156 5649887 115 µM 1.22154501522255 0.0876619401092075 no 321 0.110939866322703 147 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_763 3453-1109 128 µM 1.22148783455244 0.0876721028322204 no 322 0.110950684482502 132 1560353
SGTC_1974 st069448 26.9 µM 1.21740313909296 0.0884003521494304 no 323 0.111725434648799 118 6323587 YNR016C ACC1
SGTC_2077 5212015 200 µM 1.21687518116779 0.0884948083380531 no 324 0.111825854930735 128 780900
SGTC_344 k064-0035 6.43 µM 1.21563410878054 0.0887171428973565 no 325 0.112062167394927 136 5088750
SGTC_1455 4262-0120 131 µM 1.21537014562974 0.0887644847416236 no 326 0.112112474598078 131 1529587
SGTC_3339 9145883 14.936 µM 1.20969752396281 0.0897864217108452 no 327 0.113197490163622 123 2030670
SGTC_1510 1123-0200 71.5 µM 1.2081421279401 0.0900681520940598 no 328 0.11349629881593 163 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_3299 9121982 43.1275 µM 1.20669090627317 0.0903316050774109 no 329 0.113775601251643 132 17594604 YPL160W CDC60
SGTC_1907 st060210 83.7 µM 1.20553436501647 0.0905419715863068 no 330 0.113998539941881 151 688793
SGTC_543 3844-1095 191 µM 1.20497440685736 0.0906439545112466 no 331 0.114106591064247 176 4230703
SGTC_1252 0493-0875 34.8 µM 1.20365644058016 0.0908843268655385 no 332 0.114361197460328 119 3960963
SGTC_2004 4023728 41.89 µM 1.19759023402538 0.0919967892113802 no 333 0.115538289948309 180 360084 YDR527W RBA50
SGTC_435 c-PAF 6.7 µM 1.19552275336737 0.0923782325990898 no 334 0.115941425916053 147 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_1167 k781-0610 148 µM 1.1936680813084 0.0927214082492018 no 335 0.116303915447183 156 4525169
SGTC_2022 5136654 200 µM 1.19322671809377 0.0928032137436611 no 336 0.116390296752152 164 1713771
SGTC_83 0170-0301 39.027 µM 1.19320680778683 0.0928069053236314 no 337 0.116394194566136 121 3089716
SGTC_2351 9026858 72.31 µM 1.18969218409879 0.0934602560621548 no 338 0.117083699237133 155 1409300
SGTC_103 0844-0104 51.839 µM 1.18895865612425 0.0935970426692278 no 339 0.117227968254651 199 5375804
SGTC_168 3970-0862 530.542 µM 1.18564996667828 0.0942158770636693 no 340 0.117880280493954 199 3135186
SGTC_570 0987-0065 62.6 µM 1.18351428783754 0.0946169192858186 no 341 0.118302693688349 136 3104428
SGTC_2719 novobiocin 32.65 µM 1.18266453346875 0.0947768373916246 no 342 0.118471062778005 143 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_1971 st069429 63.5 µM 1.17872667390705 0.0955205170066667 no 343 0.119253515313712 126 1246522 YGL099W LSG1
SGTC_54 0159-0055 9 µM 1.17783848760295 0.0956888463179395 no 344 0.119430500862222 143 3319099
SGTC_523 1934-0222 13.7 µM 1.17780327946717 0.0956955234678407 no 345 0.119437520472047 158 1361595
SGTC_2810 7959871 45.46 µM 1.17753864361635 0.0957457220799217 no 346 0.119490291469768 154 2974535
SGTC_886 0866-0150 153 µM 1.17591438636907 0.0960542508380755 no 347 0.119814544696726 149 271463
SGTC_1688 st021091 57.6 µM 1.1752952814445 0.0961720424531478 no 348 0.119938300819234 144 3656366
SGTC_465 cgp-37157 41 µM 1.17415308968949 0.0963896357792176 no 349 0.12016685591922 120 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_430 0958-0115 16.4 µM 1.17320982934932 0.0965696042382316 no 350 0.120355835641095 144 6833180
SGTC_3257 9139206 32.98 µM 1.17100873747648 0.0969905193018288 no 351 0.120797632542856 143 4910041
SGTC_1969 st069479 40.1 µM 1.17090397641411 0.0970105862949555 no 352 0.12081868830445 140 3895485
SGTC_1427 4048-4900 550 nM 1.16907618833778 0.0973611898903006 no 353 0.121186468305078 152 24132586
SGTC_370 0180-0345 38.7 µM 1.16837936208099 0.0974950985254373 no 354 0.121326887931999 125 3989527
SGTC_1325 1431-0015 227 µM 1.16726349690938 0.0977098148608999 no 355 0.121551987619975 135 1103340
SGTC_650 1328-0195 38 µM 1.16539568721409 0.0980699969214839 no 356 0.121929431123492 143 2780821
SGTC_3058 9093861 49.47 µM 1.16080184763693 0.0989599940357619 no 357 0.122861245723791 157 17217477
SGTC_70 0141-0289 43.283 µM 1.15961038355245 0.0991917868378166 no 358 0.123103735736519 163 352408
SGTC_2110 5483698 200 µM 1.15788464762763 0.0995282229124559 no 359 0.123455556717141 138 2848765 YHR062C RPP1
SGTC_2190 6049624 200 µM 1.15742293128715 0.0996183767940675 no 360 0.123549804852541 152 2265554
SGTC_3088 9117578 49.47 µM 1.15655132995181 0.099788726684292 no 361 0.123727858341055 153 678341
SGTC_856 0433-0016 11.3 µM 1.15537059563911 0.100019834242794 no 362 0.123969348913634 138 3911780
SGTC_191 3914-0123 66.505 µM 1.15400325562465 0.100287954601786 no 363 0.124249417095682 160 3144412
SGTC_1842 st055362 61.2 µM 1.1512078760831 0.100837729576063 no 364 0.124823362884876 142 676032
SGTC_1352 1496-0991 99 µM 1.15037859086357 0.101001249276423 no 365 0.124993987019044 164 3000039
SGTC_1328 1441-0025 69.2 µM 1.14981715271899 0.101112064165953 no 366 0.125109594482943 136 4562601
SGTC_2744 captopril 92.04 µM 1.14824767757564 0.101422312246858 no 367 0.125433166042279 88 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_2492 derrusnin 100 µM 1.1441341266475 0.102238753108004 no 368 0.126284008345026 171 1715307 Part of coumarin class of compounds.
SGTC_1492 4158-0558 28.5 µM 1.14091798903858 0.102880401123542 no 369 0.126952026345642 133 3967268
SGTC_1009 4106-0057 9.87 µM 1.14017902992877 0.103028242501234 no 370 0.127105861039598 178 2928005
SGTC_1746 st038117 42 µM 1.13992643539887 0.103078813720336 no 371 0.127158475284856 155 2898218
SGTC_2491 paeonol 100 µM 1.13719519468391 0.103626779266444 no 372 0.127728347671911 140 11092 Increases levels of cortical cytochrome oxidase.
SGTC_551 k048-0028 34.9 µM 1.13541617702918 0.103984836371559 no 373 0.128100492391928 173 6836383
SGTC_1954 st077032 68.9 µM 1.13262027505022 0.104549370001315 no 374 0.128686875261102 157 698907
SGTC_929 2805-0021 398 µM 1.13256718711972 0.104560110670692 no 375 0.128698027349623 171 3098024
SGTC_3237 9133362 49.47 µM 1.13236774265053 0.104600469114942 no 376 0.128739930291462 158 43845137
SGTC_394 menadione 8.33 µM 1.13121799637654 0.104833345241891 no 377 0.128981674577503 171 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_2839 9003951 25.97 µM 1.12992747082359 0.105095182506853 no 378 0.129253393715765 136 2990634
SGTC_1297 1068-0111 14.1 µM 1.12855723442373 0.105373710179404 no 379 0.129542329915454 156 767057
SGTC_2999 9069765 71.4286 µM 1.12815637218774 0.105455294232124 no 380 0.129626942647136 141 2097066
SGTC_2117 5521686 200 µM 1.12756513496906 0.105575707041394 no 381 0.129751808983132 152 803312
SGTC_2831 7999036 19.48 µM 1.12615104891782 0.105864106447419 no 382 0.130050794642659 155 2988270
SGTC_1854 st056233 32.9 µM 1.12524487935171 0.106049216626058 no 383 0.130242640067783 164 5393174
SGTC_2493 resveratrol 26.09 µM 1.12423358426691 0.106256077604993 no 384 0.13045697274169 113 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_1978 st071761 42 µM 1.12253810798601 0.106603541843203 no 385 0.130816857041565 159 5147680
SGTC_649 1123-0311 367 µM 1.12238692527829 0.106634564412909 no 386 0.1308489805948 170 693629 YIL048W NEO1
SGTC_2875 9039966 71.43 µM 1.11925333348775 0.107279042775737 no 387 0.131516039164662 135 6463691
SGTC_2284 7945075 39.21 µM 1.10790875436639 0.109635733366055 no 388 0.133950612215721 174 1245402
SGTC_1937 st074714 47.2 µM 1.10068684349858 0.111155224590003 no 389 0.13551648711741 141 17250970
SGTC_1343 1487-0095 224 µM 1.09728553244423 0.111876061010909 no 390 0.13625829662862 185 4560101 YGL055W OLE1
SGTC_1405 3909-7894 12 µM 1.0921748389175 0.112965440339481 no 391 0.137378129785964 165 7104060
SGTC_949 1165-0505 146 µM 1.09147813302389 0.113114532398119 no 392 0.137531274343262 158 6244267
SGTC_2362 9071156 126 µM 1.090349401269 0.113356374041632 no 393 0.137779630788589 155 653133
SGTC_672 1441-0018 53.7 µM 1.08889731806214 0.11366803894923 no 394 0.138099584536967 144 251141
SGTC_1344 1488-0097 29.1 µM 1.08821550732351 0.113814588559342 no 395 0.138249990197686 170 747966
SGTC_541 4513-1321 94 µM 1.08464543678185 0.114584144423648 no 396 0.139039361344205 180 747515
SGTC_2073 5212005 126 µM 1.08155586204839 0.115253108904557 no 397 0.139724962985319 172 691789
SGTC_1299 1079-1439 3.74 µM 1.08130475036144 0.115307602142001 no 398 0.139780787523314 169 323161
SGTC_2611 pyromycin 23.93 µM 1.08113115749409 0.115345283882192 no 399 0.139819387746162 156 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_3297 9117502 71.43 µM 1.08110411606358 0.1153511545434 no 400 0.139825401348428 130 7453720
SGTC_2918 7977171 22.06 µM 1.07937927370233 0.115726054565781 no 401 0.140209343298056 167 2236483
SGTC_1079 idarubicin 2.36 µM 1.07661331509488 0.116329049713762 no 402 0.140826526596817 192 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1245 0418-0076 17.2 µM 1.07637594802708 0.116380900790505 no 403 0.140879577339972 157 6790114
SGTC_2645 abamectin 100 µM 1.07520960162262 0.116635918732987 no 404 0.141140448811347 169 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_1410 3909-8106 77.9 µM 1.07499217598588 0.116683501944458 no 405 0.141189115627202 182 1039210
SGTC_2462 5162487 171.77 µM 1.07396395493429 0.116908712736418 no 406 0.141419418520669 163 2259986
SGTC_964 1287-0107 19.4 µM 1.07236095389659 0.117260431579452 no 407 0.141778969314075 163 51516812 YPR165W RHO1
SGTC_916 4466-0038 42 nM 1.07232159473899 0.117269076897044 no 408 0.14178780529593 202 5722064 YGL116W CDC20
SGTC_1607 st000305 50.6 µM 1.07106235208614 0.117545910377445 no 409 0.142070697348086 161 5457690
SGTC_3293 9120939 62.045 µM 1.06748399805121 0.118335104574152 no 410 0.14287666788626 164 934087
SGTC_1213 1315-0166 115 µM 1.06580124729153 0.118707521812346 no 411 0.143256748484606 167 768401
SGTC_621 3584-0052 32.1 µM 1.06329476594742 0.119263776606275 no 412 0.143824149020104 173 2273927
SGTC_270 tamoxifen 5.46 µM 1.05727192499447 0.120607919232085 no 413 0.145193751223608 186 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_2305 7443522 69.23 µM 1.05468415727468 0.121188705884967 no 414 0.145784899919371 175 5415886
SGTC_1434 4073-0095 163 µM 1.05289713492386 0.121590923436431 no 415 0.146194069683493 179 24133745
SGTC_2412 st077135 33.4 µM 1.05174294411634 0.121851203350326 no 416 0.146458751263293 176 13258915
SGTC_3185 9108267 49.47 µM 1.05063118521464 0.122102284358227 no 417 0.146714006248113 171 4910486
SGTC_192 3455-0609 60.9 µM 1.04944053847705 0.122371584120328 no 418 0.146987704364152 153 3769639
SGTC_112 phenothiazine 287.218 µM 1.04683590718304 0.122962150736739 no 419 0.147587633195614 168 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_2052 5265182 7.135 µM 1.04240794745457 0.123970713932476 no 420 0.148611291696606 170 1239884
SGTC_2547 epiafzelechin trimethyl ether 100 µM 1.04205333287972 0.12405173469905 no 421 0.148693476516207 139 6708630 An antioxidant.
SGTC_2935 9038016 29.96 µM 1.03893969527455 0.124764715852585 no 422 0.149416391749243 174 6463195
SGTC_10 0279-0212 42.575 µM 1.03782956203343 0.125019612614027 no 423 0.149674705640045 159 39851 YBR002C RER2
SGTC_746 1095-0025 46.6 µM 1.03598318852758 0.125444362053513 no 424 0.150104992795442 189 6749286
SGTC_513 4245-1575 41.7 µM 1.03114602874676 0.126561900016636 no 425 0.151236172822472 196 719745
SGTC_1631 benzylvanillin 81.9 µM 1.02996275772214 0.126836325745611 no 426 0.151513744231212 158 75506
SGTC_428 3448-4153 16.5 µM 1.02989928232393 0.126851058739684 no 427 0.151528643839376 159 3834874
SGTC_2708 st078559 56 µM 1.02794801075676 0.127304541088815 no 428 0.151987141901748 155 17250902
SGTC_206 4546-0025 72.014 µM 1.0252143378079 0.127941750948887 no 429 0.152631032231586 189 6620745 YIL048W NEO1
SGTC_1220 1838-0075 193 µM 1.02518447001009 0.127948725247594 no 430 0.15263807728313 172 5529645
SGTC_819 1013-0258 27.7 µM 1.02399817544725 0.128225945312759 no 431 0.152918068349201 184 5753198
SGTC_4 0960-0234 25.671 µM 1.02321543509886 0.128409088777547 no 432 0.153102998289424 172 6821112
SGTC_840 0245-0196 390 µM 1.01977057202981 0.129217266328783 no 433 0.153918641440972 173 3827528
SGTC_2236 dapsone 200 µM 1.01845508522019 0.129526812696602 no 434 0.154230867684452 163 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_3126 9127922 49.47 µM 1.01671653070013 0.12993669843719 no 435 0.154644149757055 220 45595682
SGTC_1426 4048-4480 71.7 µM 1.01487328345767 0.130372246511115 no 436 0.155083117497205 171 14224343
SGTC_1417 3966-0327 90.4 µM 1.01361965296218 0.130669048114158 no 437 0.155382138117922 175 651118
SGTC_1968 st069590 43.6 µM 1.01274576827845 0.130876219618837 no 438 0.155590805245489 200 6384066
SGTC_2215 7188065 200 µM 1.01194213112305 0.131066937829443 no 439 0.15578286166861 184 940217
SGTC_3225 9130819 49.47 µM 1.00990654019372 0.131550880646128 no 440 0.156270034477113 190 4547121
SGTC_2620 irigenin 100 µM 1.00962561150061 0.131617765558723 no 441 0.156337347153737 197 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_2407 paclitaxel 400 µM 1.00823628740603 0.131948887825864 no 442 0.156670520622921 180 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1911 st060208 74.3 µM 1.00572919939776 0.132547863423648 no 443 0.157272926570916 193 688783
SGTC_978 1416-0512 87.4 µM 1.00569490916019 0.13255606876816 no 444 0.15728117641081 175 6814003
SGTC_3276 9139060 49.47 µM 1.00458338887226 0.132822235086912 no 445 0.157548749590772 209 4870619
SGTC_706 4262-0057 46.9 µM 1.0034736703785 0.133088336855424 no 446 0.157816187246365 179 883298
SGTC_2701 st077767 14.721 µM 1.00336816412854 0.1331136555128 no 447 0.157841629336405 175 5721188
SGTC_84 0443-0269 128.823 µM 1.00256873307908 0.133305605147009 no 448 0.158034494034897 176 6150058
SGTC_1174 0739-0097 51.1 µM 1.00035182332575 0.133838898427129 no 449 0.158570137961948 195 728447
SGTC_1697 st025554 27.742 µM 1.00022196133787 0.133870183045527 no 450 0.158601551746283 180 1269519
SGTC_349 k015-0014 24 µM 0.997269949802131 0.134582698183691 no 451 0.159316747879655 182 2196908
SGTC_1144 3486-0183 12.5 µM 0.997135901143425 0.134615114637018 no 452 0.159349274455979 199 6744069
SGTC_1422 4031-0024 15.5 µM 0.995991425831642 0.134892096740644 no 453 0.159627155595534 194 782427
SGTC_1310 1188-0297 994 nM 0.993249733940822 0.135557221162815 no 454 0.160294133488702 175 1588352
SGTC_1286 0929-0070 131 µM 0.99304817656328 0.135606206759861 no 455 0.160343238600339 188 1420408
SGTC_919 tnp00227 403.569 nM 0.988677129172309 0.136671510188132 no 456 0.161410568076272 178 1269246 A methoxyflavone. YNL221C POP1
SGTC_2854 9024559 71.43 µM 0.986588306107521 0.137182609510833 no 457 0.161922252630067 175 3163529
SGTC_2288 7946289 167.31 µM 0.986480427875402 0.137209040880453 no 458 0.16194870748119 187 1246052
SGTC_1507 4075-3230 155 µM 0.985001193026015 0.13757182079165 no 459 0.162311742474868 176 659771
SGTC_3176 9106582 49.47 µM 0.983997063459232 0.137818454665399 no 460 0.162558478376701 128 17018027
SGTC_2880 9042983 58.44 µM 0.980817136294777 0.13860149659276 no 461 0.163341463086754 204 6464714
SGTC_2239 6685329 187.64 µM 0.979646150963228 0.138890608279898 no 462 0.163630407770497 159 805680
SGTC_3084 9116877 49.47 µM 0.978534349053789 0.139165487592932 no 463 0.163905055673825 168 27241325
SGTC_515 4092-1064 102 µM 0.978178735111519 0.139253486853577 no 464 0.163992965924509 203 717353
SGTC_341 1486-1430 230 µM 0.977879300951604 0.139327613376075 no 465 0.164067011859714 225 2054753 YPL210C SRP72
SGTC_2973 9094665 17.96 µM 0.976507107436474 0.139667650566235 no 466 0.164406613752653 206 25237061 YIL048W NEO1
SGTC_1153 4055-0057 267 µM 0.973969435456574 0.140297985443974 no 467 0.165035857694888 206 882706
SGTC_2593 nobiletin 86.24 µM 0.972943754737506 0.140553302708954 no 468 0.165290628510962 173 72344 An anti-infammatory.
SGTC_375 3970-0961 9.27 µM 0.970637193303672 0.141128614374719 no 469 0.165864488950176 195 2898222
SGTC_2743 auranofin 4.32 µM 0.970394176909965 0.14118932133163 no 470 0.165925025058816 145 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_1309 pyrazolanthrone 13.4 µM 0.969287300127162 0.141466049760807 no 471 0.166200931976459 199 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_2184 6075246 200 µM 0.969116871665663 0.141508690928568 no 472 0.16624344033606 195 2267320
SGTC_2976 9009005 19.48 µM 0.965493443384189 0.142417333088502 no 473 0.167148859221508 167 2993148
SGTC_1025 k007-0731 70 µM 0.965352004725872 0.142452881323463 no 474 0.167184266133732 174 6256118
SGTC_337 1315-0038 354 µM 0.964860452293078 0.142576471455832 no 475 0.167307356043613 177 1626437
SGTC_2496 diffractaic acid 79.83 µM 0.963793304549938 0.1428450319886 no 476 0.167574782074189 186 94870 An apoptosis inducer which activates caspases.
SGTC_1975 st070967 30.8 µM 0.96350093222165 0.142918670624932 no 477 0.16764809827969 225 261391
SGTC_2605 digitonin 300 nM 0.963129958868779 0.143012143104936 no 478 0.167741154457891 211 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_3291 9121177 71.43 µM 0.96232457281368 0.143215214748864 no 479 0.167943294615153 181 17015612
SGTC_2595 hexamethylquercetagetin 100 µM 0.961024992354549 0.143543304065894 no 480 0.168269800847013 209 386331
SGTC_487 nimodipine 119 µM 0.957417136045083 0.144456793435084 no 481 0.169178376315134 167 4497 L-type voltage-gated calcium channels inhibitor
SGTC_3290 9121031 71.43 µM 0.956941251309089 0.144577576614295 no 482 0.169298454267536 193 17014854
SGTC_1958 st076513 41.9 µM 0.956607277347216 0.144662382372359 no 483 0.169382757145286 201 732122 YGL099W LSG1
SGTC_1018 4259-0013 28.1 µM 0.956312592355556 0.14473723933293 no 484 0.169457164934041 192 6801262
SGTC_497 capsazepine 133 µM 0.953802335302993 0.145375961579048 no 485 0.170091853545129 186 2733484 A calcium channel blocker.
SGTC_2922 7999257 32.47 µM 0.953264948189193 0.145512943042049 no 486 0.170227923207763 210 2988377
SGTC_3111 9122088 49.47 µM 0.953171033498291 0.145536891064125 no 487 0.170251710131915 177 16876704
SGTC_1625 st003711 30.1 µM 0.949734819260903 0.146414940216611 no 488 0.171123506362954 187 24207034 YER133W GLC7
SGTC_2567 aureobasidin a 60 nM 0.948184391059437 0.146812280094769 no 489 0.171517795985353 219 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_2076 5212012 200 µM 0.945907190545486 0.147397185710589 no 490 0.172097962816652 186 604802
SGTC_1490 4089-0339 670 nM 0.945894889852127 0.147400349413987 no 491 0.172101100085756 212 742542
SGTC_2002 4023503 131 µM 0.944735146068358 0.14769883661686 no 492 0.172397054549233 224 4736863 YCR052W RSC6
SGTC_2871 9038510 12.99 µM 0.943986516363558 0.147891728834875 no 493 0.17258826931982 226 4945164
SGTC_1233 0325-0408 14.2 µM 0.94377873834594 0.147945294884832 no 494 0.172641363883617 192 12874
SGTC_2191 5911152 200 µM 0.943624276837753 0.147985124128652 no 495 0.172680840958722 182 2875902
SGTC_1090 efavirenz 20.7 µM 0.942720598886087 0.148218289169661 no 496 0.172911917126781 192 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_2183 6420625 130.508 µM 0.942264752963777 0.148335998768555 no 497 0.17302855454186 220 2897619
SGTC_502 l-744,832 89.3 µM 0.942049726975915 0.148391544980041 no 498 0.173083590691129 193 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_1403 3909-7815 62.9 µM 0.939506273130464 0.149049633689711 no 499 0.173735436491295 191 6615483
SGTC_878 0828-0289 13.7 µM 0.931434517276219 0.151150999110141 no 500 0.175814421367246 202 745350 YLR208W SEC13
SGTC_843 0310-0051 143 µM 0.930393362446719 0.15142347697831 no 501 0.176083726987138 206 2065037
SGTC_2311 7694451 200 µM 0.930247232549921 0.151461746367986 no 502 0.176121545905719 231 2163142
SGTC_1865 st057639 52.2 µM 0.930217892923623 0.151469430783618 no 503 0.176129139721416 214 688818
SGTC_1385 3091-4834 14.1 µM 0.928767181092486 0.151849713678661 no 504 0.17650487802489 166 4072814
SGTC_687 k029-0044 34.9 µM 0.92811218522147 0.152021618950627 no 505 0.176674689741434 162 5829338
SGTC_1787 fluconazole 80 µM 0.925582556624464 0.152686739333955 no 506 0.177331480952145 192 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_1640 st009078 66.4 µM 0.924761586667515 0.152903012903477 no 507 0.177544968028217 217 690618
SGTC_3309 9129340 25.759 µM 0.921965633913435 0.153641092496472 no 508 0.178273250836669 197 17158987
SGTC_1303 1160-0052 261 µM 0.920535905428855 0.154019424319512 no 509 0.178646389386485 194 3562476
SGTC_3130 9127414 49.47 µM 0.920453921336211 0.154041137452306 no 510 0.178667800952848 199 1494646
SGTC_2846 9008642 19.48 µM 0.920006812041898 0.154159588055011 no 511 0.178784599726718 220 2992898
SGTC_2678 equilin 100 µM 0.91971484097546 0.154236971111222 no 512 0.178860897534475 182 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_329 k048-0121 21.3 µM 0.918267563005796 0.154620932150179 no 513 0.179239402369666 198 6832902
SGTC_3271 9137798 49.47 µM 0.914240307871575 0.155692679649178 no 514 0.180295294210946 174 6498326
SGTC_1772 st048439 82.2 µM 0.913548678779209 0.155877230207359 no 515 0.18047702196481 206 2927068 YDL195W SEC31
SGTC_2235 salicylic acid 500 µM 0.913156539602109 0.155981930537661 no 516 0.180580108810167 195 338 A COX inhibitor and kinase inhibitor.
SGTC_777 1315-0167 517 µM 0.912666011429982 0.156112965763268 no 517 0.180709112457715 213 4221767
SGTC_2154 5570129 200 µM 0.911078582541888 0.156537514105034 no 518 0.18112698515783 218 673366
SGTC_1169 aniline yellow 25.8 µM 0.91061305424327 0.156662160873308 no 519 0.181249644912432 217 6051 A DNA damaging agent.
SGTC_452 diindolylmethane 8 µM 0.910487902765868 0.156695681742233 no 520 0.18128262932827 198 3071 Inhibits expression of several cancer promoting factors.
SGTC_333 3486-0131 40.1 µM 0.909062418741789 0.157077819861326 no 521 0.181658589319601 203 6744690
SGTC_828 2074-0507 139 µM 0.907472303443734 0.157504814288532 no 522 0.182078544694682 209 X828
SGTC_2650 prasterone 100 µM 0.907127250798658 0.157597572067669 no 523 0.182169754465084 179 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_160 3453-0671 289.699 µM 0.903471775787678 0.158582448376477 no 524 0.183137780601804 214 5322268
SGTC_611 3453-1652 23.7 µM 0.902573477165982 0.158825088937693 no 525 0.18337615417599 233 1560575
SGTC_2263 7948595 193.29 µM 0.902092778505301 0.158955030950046 no 526 0.183503792352731 196 2971371
SGTC_3077 9117319 49.47 µM 0.901879738766488 0.159012641925757 no 527 0.183560377728691 222 17154678
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.900970839045501 0.159258583546197 no 528 0.18380191226123 212 688751
SGTC_2480 5767542 37.17 µM 0.90075152632523 0.159317965253291 no 529 0.183860222907522 206 2867358
SGTC_1988 st071872 53.4 µM 0.897629467872166 0.160164874360355 no 530 0.18469156172791 189 16414116
SGTC_2147 5545932 89.7195 µM 0.897509118256162 0.160197579955757 no 531 0.184723655022669 226 797404
SGTC_2917 7979103 53.79 µM 0.897344693882787 0.160242270137683 no 532 0.184767507213034 188 2980565
SGTC_2549 cedrol 20.94 µM 0.897203942256051 0.160280532592272 no 533 0.184805050991968 211 6708665 A sedative which affects the nervous system.
SGTC_1649 st011737 51.3 µM 0.896855263129059 0.160375344561724 no 534 0.184898077315715 203 1761035
SGTC_1634 st006576 41 µM 0.894556181257324 0.161001422570596 no 535 0.185512192304574 207 3915356
SGTC_1236 0330-0013 258 µM 0.89375251199147 0.161220650756865 no 536 0.185727161187543 200 4617066
SGTC_3024 9090631 49.47 µM 0.893726778694076 0.161227673607008 no 537 0.185734046991961 195 25236383
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.892609141674923 0.161532879435884 no 538 0.186033260946618 244 5393153
SGTC_1508 1080-0625 72.9 µM 0.891192125839166 0.161920381226543 no 539 0.186413053994913 206 767111
SGTC_449 xestospongin c 11.1929 µM 0.888114454248771 0.16276409564805 no 540 0.187239594157114 215 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_1333 1482-0047 286 µM 0.887950153075564 0.162809217506181 no 541 0.187283782540978 207 3811116
SGTC_161 4065-0411 162.148 µM 0.886530036345981 0.163199561651274 no 542 0.187665987997084 211 1906281 YLR208W SEC13
SGTC_1828 st055811 49 µM 0.884277823013232 0.163819868218037 no 543 0.18827312840383 206 5877589
SGTC_3021 9087658 49.47 µM 0.88404316787031 0.163884585049075 no 544 0.188336455198421 191 25237042
SGTC_3223 9129970 49.47 µM 0.88391949120176 0.163918701192594 no 545 0.188369837324841 223 17248386
SGTC_2690 usnic acid 100 µM 0.883541571690101 0.164022978643781 no 546 0.188471865895668 206 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_591 4299-0174 154 µM 0.88345414553486 0.164047107836079 no 547 0.188495473567353 220 5509088
SGTC_2817 7995342 71.43 µM 0.883028716872646 0.164164556935528 no 548 0.188610378030727 201 18879975
SGTC_1509 1326-1131 80 µM 0.881088837741415 0.164700795077281 no 549 0.189134869170669 195 768313
SGTC_2398 5228213 48.84 µM 0.878759491548401 0.165346190789904 no 550 0.189765847205175 232 80771 YMR134W ERG29
SGTC_2324 6149169 200 µM 0.878412462962482 0.165442482429907 no 551 0.189859961689791 208 2888231
SGTC_2081 5214970 32.255 µM 0.877710343452986 0.16563741372885 no 552 0.190050464925386 182 2063512
SGTC_1571 st070080 73.4 µM 0.877666724718854 0.165649528611646 no 553 0.190062303694042 200 4315245
SGTC_1087 pterostilbene 9.05 µM 0.876984216053981 0.165839166565198 no 554 0.190247605651061 219 5281727 Similar to reservatol, lowers cholesterol.
SGTC_2292 7671323 168.05 µM 0.876647217667554 0.165932854741758 no 555 0.190339142051056 243 937504
SGTC_772 k072-0172 35.3 µM 0.875762822694544 0.16617888607432 no 556 0.190579492390212 182 5861980
SGTC_1756 st041558 35.5 µM 0.875754601364504 0.16618117428492 no 557 0.190581727559138 219 3955792
SGTC_2068 5226020 147 µM 0.872449656598245 0.167102675087505 no 558 0.191481560507747 220 1810509
SGTC_2350 9023895 38.85 µM 0.871711130687538 0.167309044000333 no 559 0.191682993250299 210 2997209
SGTC_2346 9031566 143.75 µM 0.870694508371209 0.167593390940182 no 560 0.191960488894569 208 4771086
SGTC_365 0121-0052 13.6 µM 0.870485677544548 0.167651838961367 no 561 0.192017521458044 189 3101739
SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.866465469406586 0.16877958190656 no 562 0.193117477335222 229 1273210
SGTC_1687 st020778 55.3625 µM 0.865291900911801 0.169109706715309 no 563 0.19343929749685 207 4259299
SGTC_610 4215-0184 155 µM 0.864558957796448 0.16931609381433 no 564 0.193640453663643 215 5605015
SGTC_2914 7968218 45.32 µM 0.863277413654773 0.169677348034463 no 565 0.193992479694497 177 2977111
SGTC_1396 3511-0007 98.6 µM 0.862371058469525 0.16993313856085 no 566 0.194241680717685 217 X1396
SGTC_57 miconazole 162.5 nM 0.862036470768805 0.17002762796146 no 567 0.194333724359254 218 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1105 epirubicin 18.1 µM 0.861153574200691 0.170277124432776 no 568 0.194576732883975 237 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1653 st012112 65 µM 0.860036807748814 0.170593045643695 no 569 0.194884376525166 212 720429
SGTC_285 1486-1325 46 µM 0.859770985427672 0.170668299175205 no 570 0.194957648062543 228 22310230
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.858831878163344 0.170934327846624 no 571 0.195216638641676 229 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2833 9001315 45.46 µM 0.858549374980234 0.171014406736915 no 572 0.19529458933485 208 2989378
SGTC_1620 st003704 16.5 µM 0.856128194772659 0.171701703028988 no 573 0.195963437378905 215 2834414
SGTC_2905 7799065 20.05 µM 0.855777443740055 0.171801416247586 no 574 0.196060447034329 202 1296806
SGTC_1021 4476-0760 85.3 µM 0.854862436614966 0.172061712985414 no 575 0.196313654002326 191 746768
SGTC_875 0709-0210 25.7 µM 0.854855716064543 0.172063625745422 no 576 0.196315514491604 233 6251364
SGTC_1200 1643-0193 18.4 µM 0.851025168621899 0.173156059844662 no 577 0.197377685919334 239 5403974
SGTC_2606 farnesol 9.78 µM 0.850640535550165 0.173265996903295 no 578 0.197484532396723 243 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1706 st031321 9.9705 µM 0.850252994527334 0.173376810061135 no 579 0.197592222029953 214 6103185
SGTC_1053 3366-3204 134 µM 0.849563617431222 0.173574041456643 no 580 0.197783873378366 241 3632071 YPR165W RHO1
SGTC_884 0851-0618 334 µM 0.849309704675074 0.173646722084225 no 581 0.197854491082071 236 9642473
SGTC_1764 st044502 93.5 µM 0.849234877904811 0.173668144381032 no 582 0.19787530465808 203 8407
SGTC_81 0411-0046 9.971 µM 0.847567293230508 0.174145996564801 no 583 0.198339497832154 236 12925265
SGTC_983 1491-0821 12.2 µM 0.847390322932419 0.174196757022612 no 584 0.198388798282334 207 46495113
SGTC_2430 5571206 200 µM 0.846004717615202 0.174594515698511 no 585 0.198775056256857 241 1731771
SGTC_1214 0358-0031 63.7 µM 0.845563434422415 0.174721313614324 no 586 0.198898165601676 218 4301366
SGTC_2201 6605497 169.863 µM 0.844262644841129 0.175095421367271 no 587 0.199261327651772 228 670741
SGTC_3008 9078912 71.4286 µM 0.84377879507059 0.175234706371404 no 588 0.199396513494317 228 16648731
SGTC_512 prima-1 270 µM 0.841120553606926 0.176001182719443 no 589 0.200140200855977 199 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_1859 st055998 20 µM 0.839425006602401 0.176491183194686 no 590 0.200615428026471 227 676301
SGTC_778 3456-2434 196 µM 0.839398442523423 0.176498866874928 no 591 0.200622878781206 211 5539063
SGTC_139 0099-0334 718.624 µM 0.839071211246988 0.17659353612935 no 592 0.200714674999932 241 97690
SGTC_1228 0124-0032 52.5 µM 0.838249747995414 0.176831330031296 no 593 0.200945226199467 217 X1228
SGTC_3287 9117173 37.0625 µM 0.837908538291748 0.176930161519829 no 594 0.201041036518672 189 2789709
SGTC_1452 4194-0072 190 µM 0.834765879128292 0.177842074398668 no 595 0.201924770390759 224 1343545
SGTC_3198 9112019 49.47 µM 0.83387727009329 0.178100460887491 no 596 0.20217507348738 263 45595555
SGTC_2550 chrysin dimethyl ether 71.87 µM 0.832439952867906 0.178518899443911 no 597 0.202580329266666 218 88881 An O-methylated flavonoid and antioxidant.
SGTC_75 0159-0059 199.013 µM 0.830808921500258 0.178994482341972 no 598 0.203040790958918 236 5377270
SGTC_56 0957-0365 83.25 µM 0.830276013134638 0.179150042611082 no 599 0.203191373375922 206 6752360
SGTC_67 0335-0847 266 µM 0.830010012802768 0.179227722071505 no 600 0.203266561275738 239 4552207 YOR254C SEC63
SGTC_2232 chlorophetanol 41.5365 µM 0.829552457204433 0.179361390522831 no 601 0.203395933203742 231 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_2439 5492030 7.2 µM 0.829093178441344 0.179495625390721 no 602 0.2035258417417 226 5722370
SGTC_1739 st037196 92.5 µM 0.829030624662625 0.179513913067899 no 603 0.20354353911619 210 612214
SGTC_2837 9008476 45.46 µM 0.827755260912452 0.179887022610337 no 604 0.203904558164686 214 2992805
SGTC_2155 5570423 76 µM 0.826534602974218 0.180244583704115 no 605 0.204250448703766 234 797402
SGTC_2078 5212016 200 µM 0.826475653428823 0.180261862776494 no 606 0.204267161723133 221 1899708
SGTC_1798 st045719 60.953 µM 0.82435540378298 0.18088403347068 no 607 0.204868823303197 221 3980186
SGTC_2642 cholecalciferol 100 µM 0.824195528668878 0.180931002080266 no 608 0.204914233624375 224 9821465 A vitamin D precursor, similar to steriods.
SGTC_290 2043-6722 48.1 µM 0.823072964073094 0.181261007814147 no 609 0.205233251114203 228 773758 YLR208W SEC13
SGTC_2520 obtusaquinone 4.71 µM 0.822739545170243 0.181359097139966 no 610 0.205328061008996 238 5967872
SGTC_2656 pseudo-anisatin 100 µM 0.822661120836743 0.181382173814416 no 611 0.205350365271486 261 6708809 A neurotoxin.
SGTC_25 0118-0223 35.662 µM 0.821050510738902 0.181856508807721 no 612 0.205808748817192 240 5333628
SGTC_287 k060-0039 29.6 µM 0.820265556151038 0.182087963911022 no 613 0.206032368669159 240 5861974
SGTC_3048 9093155 49.47 µM 0.819985846467388 0.182170484802227 no 614 0.206112087880619 217 25236002
SGTC_338 4055-0136 114 µM 0.817934047130504 0.18277652797642 no 615 0.206697423929168 215 2900563
SGTC_548 1436-0017 110 µM 0.816365576734189 0.183240657307305 no 616 0.207145539279968 210 9677137
SGTC_3125 9127534 49.47 µM 0.815482231401885 0.183502373107816 no 617 0.207398165691021 212 1639235
SGTC_2995 9067767 71.4286 µM 0.815222730486381 0.18357930177805 no 618 0.207472414509314 198 11673567
SGTC_2876 9059903 25.97 µM 0.814793372416592 0.183706628484796 no 619 0.207595297626224 215 6916095
SGTC_1308 1187-1617 41.4 µM 0.811484549713166 0.184689709172521 no 620 0.208543731009948 228 2882570
SGTC_865 0488-0499 301 µM 0.809797179815258 0.185192298706074 no 621 0.209028376871833 221 9634651
SGTC_712 r015-0009 80.6 µM 0.806209484178506 0.186263727131964 no 622 0.210061035532814 230 6813872 YLR060W FRS1
SGTC_532 1548-0774 215 µM 0.805986944306754 0.18633031265092 no 623 0.21012518851547 247 5932993
SGTC_2724 maprotiline 69.64 µM 0.805972471005692 0.186334643676647 no 624 0.210129361224483 237 4011 A tricyclic antidepressant.
SGTC_2643 anethole 100 µM 0.80450508099689 0.186774072693215 no 625 0.210552668057454 260 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_1983 st071813 46.9 µM 0.804435420552031 0.186794949354595 no 626 0.210572775859989 223 11838595
SGTC_1117 retinoic acid 1.10837 µM 0.803997626787256 0.186926185597293 no 627 0.210699172803245 233 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_1997 st073024 93.8 µM 0.802851221935757 0.187270110462189 no 628 0.21103036609005 237 686268
SGTC_817 1391-0715 46 µM 0.801608462619732 0.187643383602599 no 629 0.211389740412138 258 1353946
SGTC_995 3931-2021 34.6 µM 0.800364057746497 0.188017611224872 no 630 0.211749949488418 226 730143
SGTC_662 k832-1615 104 µM 0.796531083143248 0.189173186941755 no 631 0.212861708153074 241 5878478
SGTC_2564 betulinic acid 100 µM 0.796218059172929 0.189267751040816 no 632 0.212952651341323 251 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_3354 9151612 71.43 µM 0.796083052508258 0.189308545344451 no 633 0.212991881968916 217 27261949
SGTC_1281 0884-0031 11.8 µM 0.795996506900066 0.189334699254477 no 634 0.213017032860299 246 1548255
SGTC_1237 0330-0133 46.1 µM 0.795977903418333 0.189340321479942 no 635 0.213022439416912 261 X1237 YHR072W ERG7
SGTC_2 0422-0095 29 µM 0.79537936143553 0.189521263854616 no 636 0.213196430819488 217 6790840
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.793779225275773 0.190005515582326 no 637 0.213661984452129 242 688664
SGTC_2085 5307070 144.047 µM 0.79361190091283 0.190056197103368 no 638 0.213710701029241 257 2840351
SGTC_1496 4469-0713 57.4 µM 0.793607455474948 0.190057543712469 no 639 0.213711995409066 246 746691
SGTC_201 4262-0159 12.803 µM 0.793101357613201 0.190210888875012 no 640 0.213859385965324 227 1341029
SGTC_1372 2752-0194 270 µM 0.791993806775972 0.190546736431737 no 641 0.214182143707092 230 823334
SGTC_481 bay k-8644 50 µM 0.790780094861266 0.190915193473221 no 642 0.214536163715266 256 2303 A calcium channel antagonist.
SGTC_2873 9040596 71.43 µM 0.789919656536731 0.191176668760257 no 643 0.2147873455031 258 6463863
SGTC_3347 9188721 44.724 µM 0.789627067713901 0.191265632450806 no 644 0.214872797841258 254 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_1546 5-methoxyflavanone 78.7 µM 0.789492355050194 0.191306601314486 no 645 0.214912148129139 217 147795
SGTC_653 0203-0016 55.2 µM 0.7892045229436 0.191394154940093 no 646 0.214996239447639 242 295302
SGTC_1826 st055655 41.6 µM 0.788533094359133 0.191598487510869 no 647 0.215192474290359 241 676168
SGTC_3195 9113082 49.47 µM 0.788502078656782 0.191607929595259 no 648 0.215201541595284 236 17018038
SGTC_947 3447-0010 211 µM 0.788369259126077 0.191648366957699 no 649 0.215240373312213 246 748350
SGTC_3098 9119039 49.47 µM 0.788367141689471 0.191649011660873 no 650 0.215240992408458 237 17161528
SGTC_2282 7944268 200 µM 0.788238089615834 0.191688307095139 no 651 0.215278726612574 241 2970414
SGTC_1269 0831-0796 3.05 µM 0.78668613725448 0.192161251878749 no 652 0.215732810585755 243 927758
SGTC_960 1222-0186 7.7 µM 0.783696157314309 0.193074434118155 no 653 0.216609208924743 237 3126296
SGTC_2151 5563267 85.4165 µM 0.782603869155513 0.193408694083948 no 654 0.216929884351225 267 5310824
SGTC_2047 4141938 200 µM 0.782149176227527 0.19354794237143 no 655 0.217063454561518 260 3807862
SGTC_1934 st074720 32.6 µM 0.778706919895617 0.194604105140877 no 656 0.218076189439647 246 17250992
SGTC_2897 9048598 12.99 µM 0.778555877082776 0.194650528698962 no 657 0.218120689536447 240 6467404
SGTC_567 1080-0542 68.4 µM 0.778534778506493 0.194657013959466 no 658 0.218126905996469 211 5950415
SGTC_50 0929-0078 56.389 µM 0.777977043275448 0.194828497757886 no 659 0.218291273481543 219 1377751
SGTC_3092 9117248 49.47 µM 0.777838644092192 0.194871064821777 no 660 0.218332071491379 263 17141857
SGTC_609 0986-0026 86.3 µM 0.776704473780643 0.195220111579933 no 661 0.218666573393822 249 2848610
SGTC_111 0083-0039 52.457 µM 0.774761726975083 0.195818883980565 no 662 0.219240234384035 211 759313
SGTC_1346 1488-2224 62.4 µM 0.771372624582708 0.196866100885533 no 663 0.220243048286063 242 3722427
SGTC_2200 6600604 21.907 µM 0.769814548613458 0.197348674759803 no 664 0.220704954178288 275 2904777
SGTC_29 0299-0004 12.984 µM 0.769689663057882 0.197387385788743 no 665 0.220742001648789 232 16871 A napthoquinone isolated from Swertia calycina.
SGTC_331 k048-0133 24.5 µM 0.768617865698072 0.197719801779525 no 666 0.221060098208747 239 6813582
SGTC_1886 st057356 49.9 µM 0.768497657478498 0.197757105226659 no 667 0.221095790914681 228 24207747
SGTC_1211 1056-0033 32.3 µM 0.766224149627142 0.19846342893714 no 668 0.221771470668457 243 6741922
SGTC_566 0958-0068 16.5 µM 0.765329211094327 0.1987418815812 no 669 0.222037766949758 256 6815365
SGTC_765 1319-0117 244 µM 0.764615779506889 0.198964028506409 no 670 0.222250185059458 235 3487746 YGL099W LSG1
SGTC_1829 berberine 14.4 µM 0.760846199688181 0.200140274945638 no 671 0.22337446803709 254 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_254 nsc-64875 3.808 µM 0.760298990132262 0.200311371021339 no 672 0.223537942690766 243 56993
SGTC_950 1165-0508 94.1 µM 0.759686414856144 0.200503009220913 no 673 0.223721025551438 252 6148369
SGTC_2376 9072922 81.32 µM 0.759626410435485 0.200521786937712 no 674 0.223738963899502 239 17087968
SGTC_2986 9022445 71.43 µM 0.758623459279362 0.200835805685033 no 675 0.224038917622075 252 6459286
SGTC_1453 4237-0541 195 µM 0.757695396077917 0.201126640121631 no 676 0.224316677898904 241 739892
SGTC_837 0091-0265 12.5 µM 0.75660949155347 0.201467259004528 no 677 0.224641926597453 258 759367
SGTC_1621 st003705 32.4 µM 0.755333368623365 0.201867985762695 no 678 0.225024490932619 244 24207032
SGTC_2983 9022671 12.99 µM 0.753211491895056 0.202535350680501 no 679 0.225661417367251 242 6405161
SGTC_2667 digitoxin 100 µM 0.753082331596786 0.202576016246012 no 680 0.225700220484557 222 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_51 1013-0126 23.419 µM 0.752963977199472 0.20261328390482 no 681 0.225735780541838 241 1627850
SGTC_2488 5268135 45.7 µM 0.752928560029318 0.202624436927607 no 682 0.225746422389914 259 1270356 YLR208W SEC13
SGTC_3093 9117344 49.47 µM 0.752870844486344 0.202642612592317 no 683 0.225763764870187 242 24824913
SGTC_859 0439-0102 54.6 µM 0.752802468965727 0.202664146537055 no 684 0.225784311456802 265 610143
SGTC_45 0kpi-0036 14.9 µM 0.751487285941375 0.203078611705776 no 685 0.226179724775429 253 2795021
SGTC_1294 1000-1494 117 µM 0.750516899530629 0.203384742297268 no 686 0.226471724754855 239 712797 YDL207W GLE1
SGTC_1932 st074806 40.9 µM 0.749676202772154 0.203650181790554 no 687 0.226724871681597 270 17251235
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.748351322997072 0.20406891505529 no 688 0.227124137587082 232 6857784
SGTC_641 4092-0595 30 µM 0.748350747891461 0.20406909693089 no 689 0.227124310986989 248 786260
SGTC_846 0335-0850 148 µM 0.747229996892561 0.204423714840341 no 690 0.227462370007629 246 6819598
SGTC_1817 st052116 64.4 µM 0.746888499257331 0.20453184130583 no 691 0.227565434348196 247 4361398
SGTC_3265 9137266 49.47 µM 0.745240073300447 0.205054251549444 no 692 0.228063300666088 201 17224265
SGTC_807 1315-0151 48 µM 0.743702473224405 0.205542253628383 no 693 0.228528246434724 277 4011080
SGTC_898 1000-0849 28.3 µM 0.743664602985441 0.205554281543454 no 694 0.228539704506227 275 6751807
SGTC_935 2996-0153 430 µM 0.742307782822667 0.205985494975708 no 695 0.228950438717117 264 23738523
SGTC_2421 5690543 90.72 µM 0.742273686415022 0.205996338121941 no 696 0.228960765654183 264 3397993
SGTC_2946 9065502 71.43 µM 0.742096332565601 0.206052744647342 no 697 0.229014485852227 213 16489101
SGTC_2399 5884133 200 µM 0.741220189894212 0.206331531902704 no 698 0.229279971799168 250 722445
SGTC_2148 5546263 113.568 µM 0.740368433629362 0.206602773615816 no 699 0.229538233588748 243 792097
SGTC_2363 9053361 176 µM 0.738885093437169 0.207075646994519 no 700 0.229988387370239 259 6469797 YMR079W SEC14
SGTC_1956 st077085 54 µM 0.7382120272955 0.207290424475668 no 701 0.230192807650903 281 24208685
SGTC_477 mead ethanolamide 10 µM 0.737907659218441 0.2073875925043 no 702 0.230285282161712 222 16061185
SGTC_3133 9127736 49.47 µM 0.736761375851776 0.207753779486278 no 703 0.230633737643262 240 27243420
SGTC_2545 solidagenone 89.61 µM 0.735423020911845 0.20818180778367 no 704 0.231040952949014 212 6708572 An anti ulcer agent
SGTC_2942 9052777 62.25 µM 0.734237167617559 0.208561497962941 no 705 0.231402102333481 291 6469503
SGTC_367 0335-0881 7.1 µM 0.734196694127216 0.208574464091447 no 706 0.231414434011698 264 23828853
SGTC_37 0566-0070 1.56 µM 0.732600192842396 0.209086299865221 no 707 0.231901156731069 252 1626686
SGTC_834 0312-0008 75.7 µM 0.732452679440175 0.209133629725563 no 708 0.231946157654521 256 6385573 YIL048W NEO1
SGTC_2261 9010538 184.68 µM 0.73197601600431 0.209286610906878 no 709 0.232091603408696 293 6457250
SGTC_1523 st012844 44.7 µM 0.731496531908794 0.209440563787294 no 710 0.23223796104643 242 4274103
SGTC_3069 9117009 49.47 µM 0.73032621416292 0.209816609401451 no 711 0.23259540418309 240 41904981
SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.730195074909454 0.209858771682753 no 712 0.232635476306836 257 140250 A respiratory chain inhibitor.
SGTC_1272 0839-0021 27 µM 0.729949637782523 0.209937694992885 no 713 0.232710484657926 265 5027250
SGTC_2581 avocatin a 64 µM 0.729929386748099 0.20994420773961 no 714 0.232716674202415 257 6710728 A skin care supplement.
SGTC_444 curcumin 90.4 µM 0.728008931803475 0.210562366744801 no 715 0.233304059368233 249 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_2572 astragaloside iv 100 µM 0.726273043157579 0.211122035228997 no 716 0.233835700740041 259 45006101 An anti-inflammatory agent.
SGTC_108 0509-0257 621.132 µM 0.725896418081212 0.211243578050692 no 717 0.233951136264719 261 536624
SGTC_2372 9071633 200 µM 0.725896298854152 0.211243616533625 no 718 0.233951172812791 255 21321366
SGTC_277 nystatin 15.5 µM 0.725890048778114 0.211245633877196 no 719 0.23395308872651 280 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2377 9073351 62.6 µM 0.725008432786229 0.211530307063609 no 720 0.234223428538022 264 7337946 YHR072W ERG7
SGTC_1054 3429-0080 167 µM 0.724781615762762 0.21160358243218 no 721 0.234293007948428 272 1162877
SGTC_3127 9126946 49.47 µM 0.724525003221358 0.211686501435168 no 722 0.234371741357914 242 27243249
SGTC_894 0960-0238 55.9 µM 0.723583598819764 0.211990859489546 no 723 0.234660706752305 274 6741907 YDL195W SEC31
SGTC_3304 9125678 46.087 µM 0.723508049830576 0.212015295727918 no 724 0.234683905156602 259 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_1182 1222-0449 220 µM 0.720088600962394 0.213123036324288 no 725 0.235735222731319 267 658318
SGTC_1552 6-methylflavone 10.6 µM 0.719454785030767 0.213328733121219 no 726 0.235930375834951 264 689013
SGTC_1358 1509-0022 2.48 µM 0.717959536798432 0.213814455042152 no 727 0.236391118162315 277 3258434
SGTC_1494 4358-1428 177 µM 0.717136511803468 0.214082084079014 no 728 0.236644934376847 253 1564571
SGTC_2413 inermin 26.06 µM 0.713643250709974 0.215220180899316 no 729 0.237723902980398 278 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_2638 epoxomicin 18 µM 0.713316200755442 0.215326912533949 no 730 0.237825057346821 260 9915668 A protesome inhibitor.
SGTC_1791 st048313 56.1 µM 0.712946927610429 0.215447460470941 no 731 0.237939299431958 241 1204976
SGTC_933 2914-0560 114 µM 0.710577167094313 0.216221991742475 no 732 0.238673148168441 245 463887
SGTC_1506 4226-2149 212 µM 0.710482520738705 0.216252959351542 no 733 0.238702483202697 267 991114
SGTC_1143 3454-2408 5.08 µM 0.710466190033704 0.216258302900895 no 734 0.238707545000109 246 X1143
SGTC_2150 5556613 200 µM 0.71042974884681 0.216270227051233 no 735 0.238718840370606 288 743190
SGTC_1373 2887-0003 58.5 µM 0.709964991271487 0.216422336686025 no 736 0.238862923041225 280 776948
SGTC_3232 9132874 49.47 µM 0.709888674657111 0.216447320124374 no 737 0.238886587021628 245 3784940
SGTC_1130 3454-2858 15.9 µM 0.709626327556297 0.216533216283506 no 738 0.238967944442368 282 715628 YIL048W NEO1
SGTC_2286 7945697 125 µM 0.709311088801065 0.21663645600269 no 739 0.239065724323907 262 1245733
SGTC_3340 9146634 11.102 µM 0.709152719696257 0.216688332138684 no 740 0.239114855065188 240 4907387
SGTC_2784 7567673 72.73 µM 0.708663497644571 0.216848629407043 no 741 0.239266660943519 261 3471247
SGTC_2879 9041815 71.43 µM 0.707132986389944 0.217350555384827 no 742 0.239741919302352 246 4942971
SGTC_1382 3002-2117 298 µM 0.705204689851756 0.217983887746876 no 743 0.240341431574331 297 1497314
SGTC_877 0771-0151 33.1 µM 0.703610268546991 0.218508364347431 no 744 0.240837757389311 254 6166523
SGTC_2603 homopterocarpin 100 µM 0.702707973359401 0.218805491333819 no 745 0.241118878844394 268 101795 A weak amylase inhibitor.
SGTC_1202 1988-0068 29.6 µM 0.70217786803348 0.218980164073303 no 746 0.241284123005995 260 2850480
SGTC_2823 7987624 58.44 µM 0.699129833060542 0.219986064131036 no 747 0.242235448007603 293 2239440
SGTC_1296 1068-0102 11.9 µM 0.698336810608666 0.220248208120492 no 748 0.242483291844942 261 767053
SGTC_671 0560-0003 407 µM 0.696763122306915 0.220768941513026 no 749 0.24297552417271 243 3238678
SGTC_1529 apigenin 74 µM 0.696567297718733 0.220833789150694 no 750 0.243036813735182 280 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 0.696237387595091 0.220943064097588 no 751 0.243140088558015 288 442882
SGTC_58 0957-0393 9 µM 0.695621577147531 0.221147119571349 no 752 0.243332924876363 264 6997992
SGTC_3144 9087057 49.47 µM 0.693515526544204 0.22184579667546 no 753 0.243993042710141 281 17249618
SGTC_2444 5485484 36.41 µM 0.692242202487418 0.222268829631816 no 754 0.244392619914454 292 6790631
SGTC_1351 1496-0003 46.5 µM 0.691767492925688 0.222426658790082 no 755 0.244541676987818 272 3891978
SGTC_1103 duloxetine 36.1 µM 0.691080333929287 0.222655235308498 no 756 0.244757529129438 270 60835 A selective serotonin reuptake inhibitor.
SGTC_1753 st043925 64 µM 0.690872415137591 0.222724423777576 no 757 0.244822861319392 272 670181
SGTC_1306 1185-0270 9.02 µM 0.690620843685227 0.222808154782442 no 758 0.244901922585037 275 1548076
SGTC_76 0433-0009 400.328 µM 0.689613161297704 0.223143723383377 no 759 0.245218744240124 286 2841569
SGTC_1350 1495-0454 146 µM 0.688318538828973 0.223575267994854 no 760 0.24562610486956 260 1069057
SGTC_1813 st051246 8.6015 µM 0.685005942872948 0.224681634693235 no 761 0.24667008542831 257 5291959
SGTC_3018 9082602 49.47 µM 0.684325454546713 0.224909293358972 no 762 0.246884838435571 281 17332089
SGTC_569 4130-2812 160 µM 0.683871464452785 0.225061249299519 no 763 0.247028167263911 288 743552
SGTC_3166 9102297 49.47 µM 0.683053721123077 0.22533510453152 no 764 0.247286448590394 273 25237072
SGTC_2616 abietic acid 100 µM 0.682408966725182 0.22555116022643 no 765 0.247490193726382 281 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_2915 7971052 15.16 µM 0.682261708308428 0.225600522619825 no 766 0.247536740593054 253 5741558
SGTC_2012 4023501 200 µM 0.681562432996666 0.225835009641965 no 767 0.247757838130423 294 3477460
SGTC_2736 butenafine 14.65 µM 0.680858288214615 0.226071268754355 no 768 0.247980581805083 279 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_3169 9102970 49.47 µM 0.679801630720187 0.226426067137181 no 769 0.248315036996182 283 17027839
SGTC_1797 st048695 56.8 µM 0.679755819255017 0.226441456556397 no 770 0.248329542763266 294 592262 YIL048W NEO1
SGTC_2938 9059746 27.26 µM 0.679339616012823 0.226581298528847 no 771 0.248461350275354 276 6471769
SGTC_1656 st012921 11 µM 0.679091383335201 0.226664726529883 no 772 0.248539980891379 267 6732821
SGTC_1722 st034304 3.6505 µM 0.678713474525199 0.226791770391908 no 773 0.248659713396754 285 4036148 YLR033W RSC58
SGTC_2335 9018011 154.17 µM 0.67761834230904 0.227160154337724 no 774 0.24900685657784 263 6458208
SGTC_1792 st045773 43.6 µM 0.6770550658722 0.227349762278438 no 775 0.249185508522326 233 2919270
SGTC_2932 9016711 44.54 µM 0.676808403432685 0.227432820901502 no 776 0.249263762834771 280 7117328
SGTC_665 3914-0008 307 µM 0.67663121085559 0.227492497491475 no 777 0.249319985713265 280 1069549
SGTC_2472 5377652 49.4 µM 0.675961724834111 0.227718052908893 no 778 0.249532473239447 296 1610903
SGTC_3190 9110366 49.47 µM 0.67552780640811 0.227864310849415 no 779 0.249670245567539 257 17123768
SGTC_783 0848-0141 92.7 µM 0.675074826392375 0.228017050125305 no 780 0.249814113182663 291 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_2161 5662504 8.5105 µM 0.674417648376347 0.228238744790108 no 781 0.250022912826283 266 2859334
SGTC_1251 0490-5699 265 µM 0.673520737401779 0.228541507225701 no 782 0.250308030168092 282 3883818
SGTC_507 nimesulide 162 µM 0.672977218630141 0.228725087850951 no 783 0.250480892172059 271 4495 A COX2 inhibitor.
SGTC_2272 7805186 180 µM 0.670770675324624 0.229471226658165 no 784 0.251183315680184 307 2956062 YPR165W RHO1
SGTC_3308 9128332 17.569 µM 0.668644350332889 0.230191528494782 no 785 0.251861187151136 258 17332805 YDL196W YDL196W
SGTC_1082 camptothecin 424.86 nM 0.668370137951536 0.230284511110909 no 786 0.25194867618147 290 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1248 0469-0687 58.6 µM 0.6683449678392 0.230293047091134 no 787 0.251956707653518 273 4017482
SGTC_221 trifluoperazine 10.304 µM 0.667345974692566 0.230631980068042 no 788 0.252275583099609 293 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_2478 5763493 32.33 µM 0.666099608667364 0.231055230881079 no 789 0.252673717328431 281 1365576 YLR208W SEC13
SGTC_3147 9097027 49.47 µM 0.665597314892098 0.231225926251698 no 790 0.252834261566651 308 25236841
SGTC_291 SEC14.278 35.5 µM 0.664869964336058 0.231473227711857 no 791 0.253066834092045 283 1068044
SGTC_1070 indatraline 8.81 µM 0.663960399795134 0.231782689898598 no 792 0.253357828380298 292 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_3336 9143619 71.43 µM 0.663924336867828 0.231794964378311 no 793 0.253369369509712 278 45595730
SGTC_1980 st071811 45.7 µM 0.66391174749239 0.231799249418933 no 794 0.253373398521462 293 4974850
SGTC_2686 alizarin 95.37 µM 0.663825324187631 0.231828666475427 no 795 0.253401057713646 263 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_2371 9071574 200 µM 0.663141261543638 0.232061583388694 no 796 0.253620043300487 288 45596039
SGTC_1172 0370-0043 85 µM 0.662823666798809 0.232169765686477 no 797 0.25372174711128 276 376585
SGTC_1323 1348-1351 11.2 µM 0.662594518655165 0.232247837846858 no 798 0.253795140840914 275 6989654
SGTC_781 4335-2806 94.4 µM 0.661849438777879 0.232501792019107 no 799 0.254033859072652 305 845254
SGTC_2424 5537928 59.2 µM 0.661754426247004 0.232534187333782 no 800 0.254064308870475 287 5382802
SGTC_2100 5377183 190 µM 0.661211641724854 0.232719302357706 no 801 0.254238298199605 267 2844202
SGTC_2585 alliin 100 µM 0.660710912741129 0.232890147070012 no 802 0.254398862029888 301 87310 A garlic compound which reacts with lipids.
SGTC_1981 st071826 47 µM 0.660366077073357 0.23300784273477 no 803 0.254509467980499 272 11838600
SGTC_132 0417-1715 25.805 µM 0.659989372628401 0.233136453257306 no 804 0.25463032462217 290 6769098
SGTC_999 SEC7.066 22.7 µM 0.65866750490158 0.233588063251504 no 805 0.25505465204913 285 740511 YDR170C SEC7
SGTC_2093 5331342 194.4 µM 0.658167501450394 0.23375901348393 no 806 0.255215252507789 276 33839
SGTC_1610 st001799 48.1 µM 0.657571908287267 0.233962736124153 no 807 0.255406625240376 287 621897
SGTC_1814 st052110 31.539 µM 0.657138721053637 0.234110969578995 no 808 0.255545861681352 289 674163
SGTC_1098 clofazimine 15.1 µM 0.656108988232213 0.234463545171774 no 809 0.255877000821263 295 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_1738 st035555 74 µM 0.655781253337733 0.234575821630823 no 810 0.255982440022642 294 5331140
SGTC_918 glabranin 770.725 nM 0.655597987597718 0.234638618350591 no 811 0.256041410342115 276 124049 Also referred to as licorice root.
SGTC_3073 9114972 49.47 µM 0.655403605295498 0.234705234362106 no 812 0.256103965435883 263 41905075
SGTC_3137 9097352 49.47 µM 0.655137538212823 0.23479643413978 no 813 0.256189602670423 314 44120435
SGTC_3014 9081533 49.47 µM 0.655128428717839 0.234799556946927 no 814 0.256192534947053 312 21367265
SGTC_1622 st003707 19.4 µM 0.654544776571699 0.234999685385321 no 815 0.256380444573299 270 10140899
SGTC_1762 st045503 25.4615 µM 0.653717741755589 0.235283428602973 no 816 0.256646835370175 281 4645554
SGTC_1411 3909-8223 150 µM 0.651929049247774 0.23589774852869 no 817 0.257223472044029 289 X1411
SGTC_2196 6573537 42.6665 µM 0.651797928269412 0.235942816305598 no 818 0.257265769158097 305 2903087
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.651785946355034 0.235946934862951 no 819 0.257269634474258 306 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_2959 9079155 11 µM 0.650099119809213 0.236527144976363 no 820 0.257814098878487 303 16189457
SGTC_1119 parthenolide 318.541 nM 0.649335907556101 0.236789921414865 no 821 0.258060640592384 311 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_500 h-89 112 µM 0.64776274411562 0.237332072809842 no 822 0.258569207657214 302 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_1377 2944-0135 198 µM 0.646340245455483 0.237822887627025 no 823 0.259029514733277 273 1894137
SGTC_1007 4101-0031 70 µM 0.646082406715373 0.237911911116352 no 824 0.25911299424869 306 1146276
SGTC_1178 0988-0033 191 µM 0.645916331332456 0.237969261319768 no 825 0.259166771238285 278 5392207
SGTC_3201 9113999 49.47 µM 0.645266135234445 0.238193864058549 no 826 0.259377367203904 294 16649224
SGTC_1520 flindersine 88 µM 0.644966378445039 0.238297450685415 no 827 0.259474487018285 298 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_3269 9137823 49.47 µM 0.643129145278702 0.238932880107306 no 828 0.260070152138104 271 17682936
SGTC_1138 3761-0006 1.03 µM 0.643014523414734 0.238972554154642 no 829 0.260107338026516 283 12061087
SGTC_214 4373-3496 70 µM 0.642461739049415 0.239163939881761 no 830 0.260286712077533 294 3779166
SGTC_1370 2001-0092 44.6 µM 0.642440336210304 0.239171351684747 no 831 0.260293658406965 294 790957
SGTC_1720 st037298 9.481 µM 0.642320317568977 0.239212916464538 no 832 0.260332612439553 310 597396
SGTC_2316 5844804 197.44 µM 0.642291457183869 0.239222911963459 no 833 0.260341980002183 284 776813
SGTC_40 0327-0103 19.753 µM 0.6417875513507 0.239397471362967 no 834 0.260505566765115 283 409036
SGTC_224 benfluorex 43.875 µM 0.63841256729623 0.240568400164404 no 835 0.261602576157773 306 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_3342 9147791 14.508 µM 0.638205101730043 0.240640480586357 no 836 0.261670088319909 284 1838168
SGTC_2013 4024628 200 µM 0.638099832604573 0.240677059069191 no 837 0.261704347766912 308 5230760
SGTC_1880 MG-132 525 µM 0.637900312299252 0.240746395867367 no 838 0.261769287225647 282 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_2819 7996655 46.38 µM 0.637723748250346 0.240807764029842 no 839 0.261826761823109 277 6456960
SGTC_3183 9108214 49.47 µM 0.636963885573495 0.241071965733087 no 840 0.262074183879969 268 4974831
SGTC_3074 9116018 49.47 µM 0.636651058328031 0.241180780498386 no 841 0.262176079676958 336 17027303
SGTC_3219 9131112 49.47 µM 0.634508269779858 0.241926851741531 no 842 0.262874585781212 277 17612988 YMR079W SEC14
SGTC_41 0478-0632 82.643 µM 0.633683208911346 0.242214453047119 no 843 0.263143792595387 323 3750424
SGTC_2758 dehydroepiandrosterone 69.35 µM 0.633328267362555 0.242338236245857 no 844 0.263259648802481 314 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_3104 9120930 49.47 µM 0.632357808278423 0.242676851478438 no 845 0.263576548569071 301 17014836
SGTC_2696 st077691 74.316 µM 0.632150421161676 0.242749246761798 no 846 0.263644295286604 313 757133
SGTC_2301 7769476 200 µM 0.629463460262492 0.243688274734321 no 847 0.264522841616827 298 977820
SGTC_1001 4048-4355 44.4 µM 0.628521496071943 0.244017932161255 no 848 0.264831184658616 298 21824233
SGTC_1270 0831-1170 17.3 µM 0.628451095427845 0.244042579799306 no 849 0.264854236977505 291 6764716
SGTC_2233 sulbentine 40.3845 µM 0.626423616732244 0.244752986697358 no 850 0.265518561536191 285 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_739 1486-1183 203 µM 0.624904890783362 0.24528586050632 no 851 0.266016741108968 289 4346692
SGTC_3295 9122362 53.5725 µM 0.624328839392728 0.245488142086804 no 852 0.266205823948012 314 4730473
SGTC_595 3909-8003 73.7 µM 0.624154296500838 0.245549450855021 no 853 0.266263129253375 313 699517
SGTC_2115 tiliquinol 12.7705 µM 0.623702149580253 0.245708307199845 no 854 0.266411605563895 310 71208 A bioactive hydroxyquinoline.
SGTC_3067 9117431 49.47 µM 0.623508537846502 0.245776347208025 no 855 0.266475196721844 317 17150885
SGTC_1731 st035964 63 µM 0.622055036714185 0.246287466726745 no 856 0.266952839599149 310 6739575
SGTC_1796 st049173 110.4 µM 0.621752687247901 0.246393858603194 no 857 0.26705225059991 322 94134
SGTC_2348 9022543 33.42 µM 0.62119428815573 0.246590414929432 no 858 0.267235898573211 302 3162678 YDL140C RPO21
SGTC_2005 4024620 188 µM 0.620525998063544 0.246825763224042 no 859 0.267455771581737 312 236743
SGTC_2685 mycophenolic acid 18.85 µM 0.619851473839942 0.247063428835542 no 860 0.267677788149678 285 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_252 miconazole 1.30953 nM 0.619317097761202 0.247251800747704 no 861 0.267853741512198 292 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_115 0527-0192 112.043 µM 0.616775216544688 0.248148884976461 no 862 0.26869150053474 321 4233931
SGTC_2524 avocatin b 10.57 µM 0.616670852925197 0.24818575419442 no 863 0.268725925049817 282 6710748
SGTC_180 1486-1293 102.781 µM 0.616005964055591 0.248420712408881 no 864 0.268945291770229 290 4140536
SGTC_3246 9135460 32.98 µM 0.615664976519664 0.24854125644792 no 865 0.269057828620462 303 41446951
SGTC_2023 5144124 124 µM 0.615639751899157 0.248550174954881 no 866 0.269066154494933 297 2830192
SGTC_2551 apiole 73.87 µM 0.61543858794002 0.248621305304415 no 867 0.269132557181999 288 10659 A possible DNA adduct former.
SGTC_597 k018-0003 82.8 µM 0.615326551034067 0.24866092557199 no 868 0.269169543273904 315 6786234
SGTC_888 0916-0002 6.97 µM 0.613168130204869 0.24942487658391 no 869 0.269882587597842 289 2802138 YIL048W NEO1
SGTC_3080 9117754 49.47 µM 0.611758488827287 0.249924477304004 no 870 0.270348779040626 310 9550191
SGTC_1451 4152-0210 104 µM 0.610538264444278 0.250357373924499 no 871 0.270752651971162 322 659563
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.610118563131899 0.25050636235694 no 872 0.270891635353316 344 6728940
SGTC_323 4013-0906 34.3 µM 0.607362680537832 0.251485830263418 no 873 0.271805124711614 274 2910086
SGTC_2798 7813637 45.45 µM 0.605213398940707 0.252251108433617 no 874 0.27251860704486 302 956368
SGTC_1961 st076550 68.7 µM 0.60504089953209 0.252312582159243 no 875 0.27257591078192 306 1579337
SGTC_3139 9095020 49.47 µM 0.601023394040302 0.253746534293685 no 876 0.273912202414838 263 25236292
SGTC_1624 st003710 6.25 µM 0.598606908396397 0.254611097274535 no 877 0.274717524057415 324 24207033
SGTC_1104 tacrolimus 29.8 µM 0.598565308250218 0.254625994347616 no 878 0.27473139800051 305 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_1928 4'-methoxychalcone 40.3 µM 0.598207318014515 0.254754210038978 no 879 0.274850804553838 317 641818
SGTC_697 0508-1955 564 µM 0.59782469939957 0.25489128384828 no 880 0.274978454101381 298 6243113
SGTC_2699 st077704 54.6 µM 0.597697054954786 0.254937021286079 no 881 0.275021045446092 296 645852
SGTC_2293 7624732 200 µM 0.597499252004682 0.255007906337033 no 882 0.275087053121075 297 894453
SGTC_1904 st060225 78 µM 0.596371922078102 0.255412095258467 no 883 0.275463396739182 286 66595
SGTC_1277 0873-0036 22 µM 0.59636868229428 0.255413257321462 no 884 0.275464478661415 302 5965735
SGTC_740 k014-0057 261 µM 0.595772043983358 0.255627309840492 no 885 0.275663760999544 324 4012779
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.593836140526387 0.256322487494808 no 886 0.276310857096939 324 5024745
SGTC_2569 tetrandrine 100 µM 0.59219241287343 0.256913518206248 no 887 0.276860874724761 276 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1491 4138-0063 26.5 µM 0.591255012722661 0.257250893878754 no 888 0.277174783749307 313 23883227
SGTC_3261 9137475 49.47 µM 0.589566250332001 0.257859269782014 no 889 0.277740741969126 267 17027690
SGTC_2227 7312221 64.1025 µM 0.589397194692193 0.257920213085058 no 890 0.277797428974695 332 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_1482 3346-2049 8.48 µM 0.589390255251036 0.257922714861734 no 891 0.277799755998773 280 3826804
SGTC_644 1498-1197 63.3 µM 0.588204430688011 0.258350407915441 no 892 0.278197541897777 309 6741615
SGTC_2851 9015922 71.43 µM 0.586798169191972 0.258858082173422 no 893 0.278669633276105 317 2996893
SGTC_790 1575-0012 79.1 µM 0.586223898633351 0.259065547837453 no 894 0.278862531845404 324 378741 YLR208W SEC13
SGTC_2763 lisinopril 49.32 µM 0.583905837747298 0.259903862559156 no 895 0.279641832686178 310 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_2863 9028737 58.44 µM 0.583425832282526 0.260077628764091 no 896 0.279803336062064 316 6460917
SGTC_1495 4469-0029 237 µM 0.583402571654596 0.260086050837561 no 897 0.279811163517994 309 793680
SGTC_1745 st081495 74 µM 0.582778887944373 0.260311923040898 no 898 0.280021079511914 294 13842402 YBL026W LSM2
SGTC_3327 9140648 26.9345 µM 0.581480376184467 0.260782513830804 no 899 0.280458370151721 334 8029710
SGTC_391 gliotoxin 8.33 µM 0.579391964991521 0.261540287358156 no 900 0.281162362250895 316 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_2374 9071832 200 µM 0.578769869164234 0.261766231208044 no 901 0.281372232241334 301 17381698
SGTC_557 1315-0110 16.2 µM 0.575574671424877 0.262928295963975 no 902 0.282451352619356 312 6833801
SGTC_2805 7950783 58.44 µM 0.575048358192091 0.263119964051251 no 903 0.282629296162143 317 1178958 YDL195W SEC31
SGTC_1423 4048-0112 5.59 µM 0.574561973884732 0.263297154627201 no 904 0.282793787849812 310 X1423
SGTC_1795 st049545 62.3 µM 0.571217435063721 0.264517223406601 no 905 0.283926130535527 277 5291882
SGTC_1724 st037281 8.293 µM 0.571106293253993 0.264557816638426 no 906 0.283963796446981 300 574124 YDL195W SEC31
SGTC_2458 5808907 16.39 µM 0.570211521209848 0.264884736973649 no 907 0.284267121385926 330 2731747
SGTC_439 amiodarone 34.4 µM 0.56957144570265 0.265118725467712 no 908 0.28448419997578 332 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_2297 7971671 152.32 µM 0.567563804979462 0.265853326850743 no 909 0.285165595081786 319 909016
SGTC_1643 st009866 20.2 µM 0.567217157824556 0.265980270371043 no 910 0.285283326145491 293 3156273 YOR207C RET1
SGTC_2745 rifampicin 24.3 µM 0.565508030145052 0.266606608100905 no 911 0.285864131963435 296 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_2490 carminic acid 95.39 µM 0.56549305502308 0.266612099272713 no 912 0.285869223381164 284 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2386 9075165 157.42 µM 0.562696643155522 0.267638506507431 no 913 0.286820735234096 305 16452277
SGTC_1154 4088-0362 150 µM 0.562594373597984 0.267676081691083 no 914 0.286855562080259 312 6618304
SGTC_2208 7283366 200 µM 0.562564513171551 0.267687053306859 no 915 0.286865731119389 322 898663
SGTC_182 3448-4371 550.524 µM 0.561203460843646 0.268187385206778 no 916 0.287329421968451 292 3491403
SGTC_52 0329-0193 875 nM 0.559876911958387 0.268675485835802 no 917 0.287781698953957 346 3739292
SGTC_1562 morin hydrate 59.1 µM 0.557701787417092 0.26947678272116 no 918 0.288524018469785 317 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_1671 st016596 74.5 µM 0.556231885609456 0.270018959116066 no 919 0.289026172173851 323 2829167
SGTC_2608 thymoquinone 42.66 µM 0.556152130688333 0.270048392491875 no 920 0.289053430121577 316 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_229 benomyl 22.8748 µM 0.555596437257494 0.270253514460494 no 921 0.289243383773835 315 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_2157 5649910 96.377 µM 0.554938584803796 0.270496446842308 no 922 0.289468334441107 314 2858091
SGTC_2670 beta-carotene 100 µM 0.553572272513029 0.271001348333171 no 923 0.289935803192133 297 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_181 1447-1644 8.07 µM 0.553307382008729 0.271099289275824 no 924 0.290026473523187 335 534600
SGTC_1209 2323-2347 50.3 µM 0.552465752630237 0.271410591461654 no 925 0.290314646068792 313 5412760
SGTC_539 4859-0462 2.54 µM 0.55202160958805 0.271574943017224 no 926 0.290466773966154 318 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_255 tunicamycin 200.472 nM 0.551684745195141 0.271699630013542 no 927 0.290582181651955 308 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_18 0111-0177 500 nM 0.549879845517554 0.272368180622612 no 928 0.291200894391242 324 721752
SGTC_3044 9093193 49.47 µM 0.549696319316194 0.272436206073859 no 929 0.291263840909041 325 25236277
SGTC_729 4092-0585 94.1 µM 0.549171353627593 0.272630835371582 no 930 0.291443930705166 312 2169061
SGTC_3036 9090181 49.47 µM 0.54836214106346 0.272930983378418 no 931 0.291721633263823 336 25236586
SGTC_464 bw-b 70c 158 µM 0.545943937344859 0.27382890352457 no 932 0.292552237432804 339 5353454
SGTC_2483 5729050 27.16 µM 0.54577660107518 0.273891092321658 no 933 0.292609754695755 332 2865180
SGTC_2849 9019321 12.99 µM 0.545645913101636 0.273939666013402 no 934 0.292654678763402 324 16489627
SGTC_185 k048-0037 25.491 µM 0.544692186976666 0.274294272787738 no 935 0.292982619641714 301 6827589
SGTC_1953 st076800 12.1 µM 0.543310019316747 0.274808581154354 no 936 0.293458183478306 316 297591
SGTC_2278 7948257 134.34 µM 0.541383035714494 0.275526409469319 no 937 0.294121798794519 317 1247028
SGTC_1246 0422-0085 105 µM 0.540895968926389 0.275707994551182 no 938 0.294289644768093 361 264295
SGTC_3134 9127454 49.47 µM 0.540786246791687 0.275748908562902 no 939 0.294327461741594 337 24262820
SGTC_2310 7668677 200 µM 0.540309981148341 0.275926536644541 no 940 0.29449163808276 351 2197143
SGTC_673 1082-0474 110 µM 0.53952641898019 0.27621889631358 no 941 0.294761836352709 327 3098046
SGTC_2341 7987486 176.74 µM 0.538610593233345 0.27656079821623 no 942 0.295077788297552 322 1258686
SGTC_1139 k015-0024 46.9 µM 0.538179451316899 0.276721826653675 no 943 0.295226582501503 328 2766652
SGTC_2770 toltrazuril 17.5 µM 0.53786456767024 0.276839462474837 no 944 0.295335275873536 312 68591 Kills coccidiodes.
SGTC_2207 7258803 200 µM 0.536450220891163 0.277368143150074 no 945 0.295823715286762 338 3666799
SGTC_2766 oltipraz 83.91 µM 0.536333692943166 0.277411723121434 no 946 0.295863974321405 312 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_2788 5282734 71.43 µM 0.536205618418856 0.277459625226684 no 947 0.295908225464784 348 743706
SGTC_27 0485-0001 32.618 µM 0.535396471514794 0.277762353704112 no 948 0.296187864763896 331 2054479
SGTC_572 0960-0087 17.7 µM 0.534103371962624 0.278246479383255 no 949 0.296635008476043 340 6796365
SGTC_1726 st035556 14.5795 µM 0.533960706160549 0.27829991745735 no 950 0.296684360126216 304 5919439
SGTC_1642 st009582 77.7 µM 0.53147645896856 0.279231238671061 no 951 0.297544325125839 348 6739311
SGTC_2646 retinol 96.75 µM 0.530899846697021 0.279447621652604 no 952 0.297744092008007 337 445354 A vitamin A analog and teratogen.
SGTC_1924 st058459 75.1 µM 0.529384890027409 0.280016521139238 no 953 0.298269238916576 329 688683
SGTC_3012 9080433 71.4286 µM 0.528219184616723 0.280454650985832 no 954 0.298673607709026 351 17688859
SGTC_2619 obliquin 87.91 µM 0.527206236548152 0.280835636325038 no 955 0.299025189129437 340 6708593 A bioactive alkalod. YER133W GLC7
SGTC_3274 9138298 49.47 µM 0.525641065972538 0.281424812609529 no 956 0.299568809173136 327 17015756
SGTC_2334 9017922 200 µM 0.5255463558549 0.281460483415537 no 957 0.299601718559778 343 3163164
SGTC_3188 9110789 49.47 µM 0.523256103690862 0.282323727864746 no 958 0.300398021896261 337 849217
SGTC_1553 gossypol 38.6 µM 0.521920245873661 0.282827828400535 no 959 0.300862930640193 336 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_3230 9131665 49.47 µM 0.521680092293976 0.28291849880346 no 960 0.300946543922844 335 15943720
SGTC_2954 9074818 52.69 µM 0.521557489467706 0.282964793095453 no 961 0.300989234083362 346 16648742
SGTC_723 4182-0001 115 µM 0.520345509444791 0.283422627028869 no 962 0.301411390910614 338 744821 YLR208W SEC13
SGTC_626 0214-0009 33 µM 0.519814298486986 0.283623407555128 no 963 0.301596506258212 334 3437874
SGTC_1371 2421-0008 32.7 µM 0.519359149727106 0.283795493220062 no 964 0.30175515626945 331 2827552
SGTC_1499 4480-0877 67.3 µM 0.51823459384473 0.284220886984844 no 965 0.302147300535088 331 2861909
SGTC_79 0052-0007 94.094 µM 0.517922981354907 0.284338816780485 no 966 0.302256003497278 318 2801472
SGTC_2114 5491910 81.25 µM 0.514247042879364 0.285731738322984 no 967 0.303539640749393 371 2849228
SGTC_3233 9132340 49.47 µM 0.514225071709567 0.285740073596917 no 968 0.303547320393729 358 17682950
SGTC_752 1896-0090 130 µM 0.513461707181997 0.28602974546822 no 969 0.303814195186463 335 772567
SGTC_314 1671-0008 2.74 µM 0.512832158405742 0.286268743589346 no 970 0.304034366271176 332 3913060
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.510948750253556 0.286984314980085 no 971 0.304693471829096 352 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_2980 9014342 25.29 µM 0.51072991499068 0.287067512917233 no 972 0.304770095210918 343 2996599
SGTC_2038 4100038 30.985 µM 0.51012700104892 0.287296790963303 no 973 0.304981244902336 324 3596803
SGTC_2780 5215298 71.43 µM 0.509290553149656 0.287615021471031 no 974 0.305274289310366 351 2834131
SGTC_573 3702-0553 84.7 µM 0.506781186475648 0.28857072009138 no 975 0.306154179160037 323 1222756
SGTC_2366 9070441 60.58 µM 0.506228380700056 0.288781458494845 no 976 0.306348166835735 314 6837235
SGTC_594 1487-1584 10.8 µM 0.503956504949016 0.289648293726955 no 977 0.307145971040579 348 5013332
SGTC_2069 5228469 200 µM 0.502803710654984 0.290088609522232 no 978 0.307551142264956 356 2835210
SGTC_607 4491-0986 66.8 µM 0.502260394790966 0.290296240564804 no 979 0.307742182312313 322 698981 YDR232W HEM1
SGTC_220 paclitaxel 373.376 µM 0.502056808969632 0.290374059890201 no 980 0.307813780336414 339 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_12 0849-0099 9.267 µM 0.501407831033719 0.290622192560058 no 981 0.308042064803121 348 6071388
SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.501151656701984 0.290720166518085 no 982 0.308132197137287 365 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_1619 st003326 88.7 µM 0.500677642908447 0.290901493972264 no 983 0.308299004584777 316 2849032
SGTC_1773 st048542 73.5835 µM 0.498827493480572 0.291609748475168 no 984 0.308950458548254 340 3237138
SGTC_2032 5185112 25.99 µM 0.497755943661607 0.292020315070075 no 985 0.309328035887873 318 5718189
SGTC_2226 7298446 200 µM 0.497448246021236 0.292138259790159 no 986 0.309436495206065 362 3283010
SGTC_148 3253-0744 288.01 µM 0.496379392075834 0.292548138301331 no 987 0.309813380934365 337 6893655
SGTC_467 ro 31-8220 72.8 µM 0.495394970714579 0.292925875282518 no 988 0.310160672059682 350 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_1844 rapamycin 4 nM 0.494459737674098 0.293284947505866 no 989 0.310490767107178 321 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_863 0466-0191 129 µM 0.492632502585686 0.293987081932884 no 990 0.311136138980133 354 765160 YPR165W RHO1
SGTC_1691 st019933 84.6 µM 0.491830883070493 0.294295357792298 no 991 0.311419451189293 372 6176082
SGTC_179 1273-0063 6.77 µM 0.490531787159202 0.294795263083024 no 992 0.311878821062765 370 3108139
SGTC_1705 st027868 56.3335 µM 0.489601644108554 0.295153431893402 no 993 0.312207906412477 362 292948
SGTC_1004 4084-0029 199 µM 0.486981350307154 0.296163500256564 no 994 0.313135773672891 361 716894 YLR208W SEC13
SGTC_340 k038-0059 454 µM 0.48574194621887 0.296641816388843 no 995 0.313575069723435 358 23733424
SGTC_35 0133-0054 64.071 µM 0.484543602050009 0.297104622636374 no 996 0.314000063994509 348 99677
SGTC_1735 st034310 56.75 µM 0.483846768768686 0.297373894701472 no 997 0.314247310330169 350 871153
SGTC_1583 clindamycin 39.6 µM 0.483615609382825 0.297463244509719 no 998 0.314329347381288 360 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_885 0865-0106 16.8 µM 0.482505572649221 0.297892476589951 no 999 0.314723420332387 345 2793380
SGTC_483 fpl-64176 144 µM 0.482062671090618 0.298063817774513 no 1000 0.314880713284461 362 3423
SGTC_2294 7971431 200 µM 0.481578770554666 0.298251071167602 no 1001 0.315052605089285 385 5741572
SGTC_544 k015-0020 52.4 µM 0.481203925990186 0.298396160340263 no 1002 0.315185785421682 338 3008304
SGTC_2036 5160441 105 µM 0.479780944104152 0.298947238878488 no 1003 0.315691582106774 352 134534 YIL048W NEO1
SGTC_1330 1469-0054 61.8 µM 0.479452752691981 0.299074403218475 no 1004 0.315808286281824 371 7102664
SGTC_2522 biochanin a 4.94 µM 0.479283218524586 0.299140102247388 no 1005 0.315868579469116 361 5280373 A possible chelator.
SGTC_2654 protoveratrine a 100 µM 0.478507414141137 0.299440830758004 no 1006 0.316144549283258 364 5702278 A heart drug and vasodilator.
SGTC_2898 9056270 58.44 µM 0.477506094057176 0.299829179421489 no 1007 0.31650089119582 331 19154699
SGTC_1750 st081859 2.357 µM 0.477115535836469 0.299980714019681 no 1008 0.316639926196619 360 5291695
SGTC_1081 sertraline 6 µM 0.476718051344921 0.30013497154827 no 1009 0.316781453487381 358 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_1126 isoteolin 1.0172 µM 0.476688030797469 0.300146623511156 no 1010 0.316792143614693 329 133323
SGTC_1659 st012954 42.1 µM 0.476498452562968 0.30022020979015 no 1011 0.316859654759529 339 24207262
SGTC_2447 5741742 33.78 µM 0.476065271400326 0.300388383060157 no 1012 0.317013938794213 333 1776504
SGTC_1093 fluphenazine 7.97 µM 0.474846553279394 0.300861752326849 no 1013 0.317448174340995 362 6602611 An atypical antipsychotic.
SGTC_1557 sumaresinolic acid 42.3 µM 0.474798741317848 0.300880330100972 no 1014 0.317465215116706 336 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_441 propafenone 146 µM 0.474721455986362 0.300910361116064 no 1015 0.317492761384818 365 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_1521 st012942 49.4 µM 0.473975114060079 0.301200439176741 no 1016 0.317758826784619 314 24207259
SGTC_245 methotrexate 289.6 µM 0.472828644434768 0.301646278640715 no 1017 0.318167718089795 335 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_1955 wogonin 32.4 µM 0.472667665229436 0.301708904039908 no 1018 0.318225149493363 309 5281703 A flavanone.
SGTC_1996 st072960 66.8 µM 0.471934289095697 0.301994281755367 no 1019 0.318486846155793 351 1719405
SGTC_2058 5236698 133 µM 0.471634018484682 0.302111160646011 no 1020 0.318594020342584 333 766665
SGTC_1963 st076565 50.3 µM 0.471618086087079 0.302117362822469 no 1021 0.318599707442978 362 4914280
SGTC_2087 5276107 200 µM 0.471375745760806 0.302211708304741 no 1022 0.318686216562742 341 144405
SGTC_2277 7947813 106.88 µM 0.470365098175233 0.302605305863197 no 1023 0.319047097660409 371 1246798
SGTC_2987 9018338 71.43 µM 0.470280807676226 0.302638143245865 no 1024 0.319077203789661 362 5055682
SGTC_1973 st070275 50.2 µM 0.470190395771777 0.302673367143363 no 1025 0.319109497634541 339 17118334
SGTC_1786 berberine 21.6 µM 0.469959696186563 0.302763254542399 no 1026 0.31919190646178 377 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_692 k241-0027 77.8 µM 0.469384223205775 0.30298752797042 no 1027 0.319397511668779 357 3600480
SGTC_882 0843-0131 351 µM 0.469333391685673 0.303007341612071 no 1028 0.319415675444365 351 5425421
SGTC_1514 1189-1591 158 µM 0.468980205406024 0.303145026261141 no 1029 0.319541892493112 378 767698 YMR146C TIF34
SGTC_1921 5740136 50 µM 0.468286006393939 0.303415731387657 no 1030 0.319790037092297 370 1774243
SGTC_1380 2291-0730 164 µM 0.468250379015479 0.303429627311233 no 1031 0.319802774438406 331 2999191
SGTC_2079 5212404 121 µM 0.467013996768431 0.30391203565178 no 1032 0.320244932019577 331 758462
SGTC_2204 7233102 200 µM 0.465013873395744 0.304693161754571 no 1033 0.320960760786806 364 2172480
SGTC_32 0928-0142 34.1 µM 0.46444477063944 0.304915581588173 no 1034 0.321164560108748 368 2244242
SGTC_2845 9003024 42.97 µM 0.462171585723058 0.305804718627263 no 1035 0.321979138964039 332 2990173
SGTC_1040 k898-0338 155 µM 0.461461091828789 0.306082857605154 no 1036 0.32223391494138 377 20969351
SGTC_226 1,3-diallylurea 8.28947 mM 0.459795296819687 0.306735409178519 no 1037 0.322831579692807 340 74537 YKL182W FAS1
SGTC_1466 k213-0079 57.5 µM 0.456968883849815 0.307844018152662 no 1038 0.323846705486399 360 3657981
SGTC_1627 st003713 25.6 µM 0.456701188128036 0.307949108125947 no 1039 0.32394291837332 347 16195070 YER133W GLC7
SGTC_826 1683-5028 118 µM 0.455630461869301 0.308369603227583 no 1040 0.324327867136473 360 722377
SGTC_2212 7123476 200 µM 0.455358770841875 0.308476341630029 no 1041 0.324425575707543 352 1085715
SGTC_2296 7971656 126.45 µM 0.455306501248318 0.308496878478625 no 1042 0.324444374871131 348 666570
SGTC_1275 0867-0008 21.1 µM 0.453681921863307 0.309135478067187 no 1043 0.325028890258721 355 3422836
SGTC_816 0325-0417 81.3 µM 0.452524222766917 0.309590905829971 no 1044 0.325445687554362 364 68101
SGTC_2396 5342950 42.78 µM 0.452327965161251 0.309668140714177 no 1045 0.325516366299359 357 1886677
SGTC_2497 7-hydroxyflavone 100 µM 0.452058163746517 0.30977433162262 no 1046 0.32561354080292 389 5281894
SGTC_2309 7664088 163.95 µM 0.45133807938397 0.310057826727388 no 1047 0.325872951946089 378 704922
SGTC_2113 5491891 107.031 µM 0.450216862163401 0.310499471483436 no 1048 0.326277039446306 349 789979
SGTC_1208 2323-2347 50.3 µM 0.449415601664635 0.310815253555046 no 1049 0.326565939338798 375 5412760
SGTC_1758 st042942 75.2445 µM 0.449354499172427 0.310839340175135 no 1050 0.32658797452744 356 669317
SGTC_62 0180-0423 3.232 µM 0.448969918642302 0.310990960534284 no 1051 0.326726678410785 367 30102 YGL099W LSG1
SGTC_1408 3909-7976 48.8 µM 0.448969737330875 0.310991032023641 no 1052 0.326726743808718 356 24152374
SGTC_2359 9039622 200 µM 0.447887871406894 0.311417728298874 no 1053 0.327117061019022 372 6463596
SGTC_3032 9089427 49.47 µM 0.446721067809021 0.311878208740947 no 1054 0.327538234197195 350 17173707
SGTC_1399 3562-5772 25 µM 0.444859129059499 0.312613634274255 no 1055 0.328210780195042 344 23847490
SGTC_1065 prochlorperazine maleate 2.48 µM 0.442336982041485 0.313611018389401 no 1056 0.329122686679184 371 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_2857 9024691 58.44 µM 0.441986288273438 0.313749808572412 no 1057 0.329249564095418 377 16478292
SGTC_1051 3253-3903 78 µM 0.439970715050912 0.31454800029844 no 1058 0.329979158830512 353 5509239
SGTC_2913 7966556 36.57 µM 0.439780068803786 0.314623543518932 no 1059 0.330048202271557 370 2976516
SGTC_1794 st048918 76.9 µM 0.438967339041357 0.314945673202003 no 1060 0.330342601120643 364 672303
SGTC_407 eburnamonine 100 µM 0.437204772983648 0.315644759083025 no 1061 0.330981424285965 344 3195
SGTC_2514 salinomycin 42.74 µM 0.434728125079986 0.316628186233519 no 1062 0.33187989055182 375 23682228 A polyether potassium ionophore.
SGTC_2109 5483026 200 µM 0.434135283086437 0.316863784627465 no 1063 0.332095102621578 374 759335
SGTC_758 0868-0029 16 µM 0.43265156368102 0.317453747637187 no 1064 0.33263396153934 342 762687
SGTC_2011 4012611 177 µM 0.431668292520917 0.317844975974804 no 1065 0.332991257787328 373 2049887
SGTC_20 0481-0013 4.944 µM 0.431120462170281 0.318063037444731 no 1066 0.333190391507973 361 182045
SGTC_1994 st072947 40.9 µM 0.430943811532506 0.318133365911483 no 1067 0.333254613204031 383 5286565 YDL195W SEC31
SGTC_615 k087-0205 167 µM 0.430539817840858 0.318294229244288 no 1068 0.333401504300063 364 9642773
SGTC_1254 0550-0035 264 µM 0.429351087801523 0.318767759774554 no 1069 0.333833871702331 386 15121435
SGTC_2096 5468907 200 µM 0.427061526073624 0.319680640299189 no 1070 0.334667257486165 357 759785
SGTC_2031 5180455 200 µM 0.42560592725544 0.320261577064375 no 1071 0.335197510260279 359 29949
SGTC_119 0121-0043 24.815 µM 0.425224094607244 0.320414041425687 no 1072 0.335336660597993 366 1092378
SGTC_699 0375-0592 111 µM 0.425166068143327 0.320437213831786 no 1073 0.335357809018432 354 762578
SGTC_3033 9090887 49.47 µM 0.423913667905529 0.320937520370608 no 1074 0.335814387927962 354 19325384
SGTC_2820 7989630 71.43 µM 0.42162237365496 0.32185368392009 no 1075 0.336650336420394 344 2984098
SGTC_1883 5-benzylidenerhodanine 20 µM 0.42059392468475 0.322265257387199 no 1076 0.337025815398543 362 1273210
SGTC_3192 9110362 49.47 µM 0.41943879259567 0.322727787916563 no 1077 0.337447739114365 374 16649480
SGTC_2046 4110841 106 µM 0.419253538452195 0.322801991734803 no 1078 0.337515424107838 376 44119630 YMR134W ERG29
SGTC_2211 7117706 200 µM 0.418971980266969 0.322914783788275 no 1079 0.337618305092852 373 822771
SGTC_2321 7390090 138.78 µM 0.418823360204183 0.322974327472536 no 1080 0.337672615559926 369 649046
SGTC_1101 ebselen 5.29 µM 0.417696761098471 0.323425839720971 no 1081 0.338084420345921 389 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_149 3970-0822 46.1 µM 0.417580926579746 0.323472278007723 no 1082 0.33812677223279 367 3114250 YBL034C STU1
SGTC_1486 3970-0793 4.53 µM 0.416078424002932 0.324074883186313 no 1083 0.338676308779907 392 2844330
SGTC_1789 tunicamycin 25 nM 0.415903092126471 0.324145233212412 no 1084 0.338740458384369 373 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_3059 1327-0034 3 µM 0.414993271608468 0.324510389682452 no 1085 0.339073414331205 347 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_172 1112-0046 2.638 µM 0.414986243296602 0.324513211152841 no 1086 0.339075986886701 354 2802135 YIL048W NEO1
SGTC_2084 5306078 60.6385 µM 0.414973270971289 0.324518418835478 no 1087 0.339080735134348 399 679340
SGTC_2707 st078556 66.6 µM 0.414323604152375 0.324779268579215 no 1088 0.339318564730347 361 17250899
SGTC_420 mitomycin C 81.9 mM 0.414179094909061 0.324837302624375 no 1089 0.339371475285478 357 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1198 1612-1005 86.7 µM 0.41327321710225 0.325201194529274 no 1090 0.33970322512791 363 6998509
SGTC_442 cape 100 µM 0.412889923146547 0.325355214273851 no 1091 0.339843632145488 378 5281787
SGTC_156 3474-0145 5.642 µM 0.410692611816444 0.326238739177745 no 1092 0.340648972545351 369 2265471
SGTC_1120 ficusin 1.78878 µM 0.410362178339948 0.326371688924329 no 1093 0.340770143264054 377 6199 A DNA cross-linker.
SGTC_1019 4262-0212 3.4 µM 0.40936715272226 0.326772170184569 no 1094 0.341135120649395 369 4677213
SGTC_2248 tofa 1.1 µM 0.408759155064798 0.327016977431593 no 1095 0.341358208613407 376 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_511 blebbistatin 171 µM 0.408165594867087 0.327256043336446 no 1096 0.341576052640772 377 3476986 A myosin inhibitor.
SGTC_556 4058-0063 51.5 µM 0.40790017938121 0.327362966626308 no 1097 0.341673480530833 378 6615692
SGTC_694 1315-0438 43.2 µM 0.407443991261814 0.327546776239748 no 1098 0.341840961287981 380 6793154
SGTC_1028 k015-0029 4.8 µM 0.407207027692857 0.327642271295279 no 1099 0.341927970225314 365 4588309
SGTC_2741 miltefosine 3.04 µM 0.406987271521807 0.32773084193835 no 1100 0.342008668406643 379 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_1413 3910-0535 34.4 µM 0.406903253978862 0.327764706974773 no 1101 0.34203952297631 379 2876951
SGTC_44 0929-0055 61.211 µM 0.406671478808847 0.327858136171655 no 1102 0.342124645467437 349 1379590
SGTC_696 1560-0013 611 µM 0.405816215915727 0.328202988158716 no 1103 0.342438821458062 346 1650269
SGTC_2177 5811945 192 µM 0.405168703706843 0.328464170082891 no 1104 0.342676753961281 397 5343475
SGTC_2082 5219693 150 µM 0.404983197429217 0.328539011752584 no 1105 0.342744930938189 361 2834649
SGTC_917 harmaline 728.087 nM 0.404957730027637 0.328549286997813 no 1106 0.342754291077682 340 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_2055 5235184 200 µM 0.404292727512127 0.328817639156973 no 1107 0.342998736359318 408 2836034
SGTC_1951 sophoraflavanone G 9.2 µM 0.403540291154192 0.329121380430111 no 1108 0.343275400309283 371 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_1136 pergolide 1.05886 µM 0.402199131116602 0.329663055656143 no 1109 0.343768740816714 382 47811 A dopamine receptor agonist.
SGTC_3035 9091303 49.47 µM 0.401984286544063 0.329749861537089 no 1110 0.343847795313099 362 25237002
SGTC_646 4092-0839 27.3 µM 0.400189597326599 0.330475346347426 no 1111 0.344508438003611 398 877796
SGTC_562 3772-2733 112 µM 0.399868111459848 0.330605371138264 no 1112 0.344626830281925 394 2876874 YIL048W NEO1
SGTC_3096 9117468 49.47 µM 0.399804448157629 0.33063112215347 no 1113 0.344650277110285 369 41316311
SGTC_3089 9117425 49.47 µM 0.399685022202433 0.330679430631906 no 1114 0.344694262613058 388 9401657
SGTC_842 0271-0008 11.1 µM 0.39963070644929 0.330701402596291 no 1115 0.344714268219581 356 1221709
SGTC_1235 benzylparaben 21.5 µM 0.397818050818961 0.331434997443744 no 1116 0.345382155244358 401 7180
SGTC_3186 9110464 49.47 µM 0.396506130902886 0.331966344835125 no 1117 0.345865842954384 382 17018021
SGTC_117 lucigenin 22.078 µM 0.396407298210001 0.332006387277121 no 1118 0.345902291477985 390 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_2760 etidronate 98.04 µM 0.396117307996317 0.332123888989183 no 1119 0.346009245253213 377 3305 A chelator and antioxidant.
SGTC_2584 androsterone 48.74 µM 0.394741686757005 0.332681504419348 no 1120 0.346516767159485 356 2754130 A steroid.
SGTC_1776 st049249 45.9 µM 0.394592989910412 0.332741801684158 no 1121 0.346571643920309 359 1822314
SGTC_1146 3579-1023 7 µM 0.394200655337908 0.332900915947551 no 1122 0.34671645094786 386 X1146
SGTC_1681 tripelennamine 100 µM 0.393695138429014 0.333105976533665 no 1123 0.346903065537639 337 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_2950 9072895 21.46 µM 0.393129183702659 0.333335612655657 no 1124 0.347112035177483 335 17332245
SGTC_2074 5212007 75.395 µM 0.391992431370829 0.333797038613364 no 1125 0.347531903049547 399 758611
SGTC_3277 9138724 49.47 µM 0.391953925542933 0.333812673151794 no 1126 0.347546128740958 383 15943418
SGTC_1191 1487-1166 10.6 µM 0.390869119191328 0.334253256032751 no 1127 0.347946990532185 392 3955771
SGTC_372 0155-0182 15.9 µM 0.389682805982626 0.334735326393488 no 1128 0.348385556125624 362 771486
SGTC_2422 chlorphenesin carbamate 384.24 µM 0.38917851468665 0.334940332848531 no 1129 0.348572047951217 351 2724 A muscle relaxant with antifungal properties.
SGTC_1556 plumbagin 1.48 µM 0.387946735337699 0.335441287300311 no 1130 0.349027725752901 384 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_1876 myriocin 605 nM 0.387753836819085 0.335519764059717 no 1131 0.3490991053293 405 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_203 k066-0004 30.888 µM 0.387328835682403 0.335692692271184 no 1132 0.349256390284298 372 6795412
SGTC_1608 st001473 40.5 µM 0.387146977257962 0.335766699065169 no 1133 0.349323700590571 415 7292267
SGTC_1435 4092-0789 56.7 µM 0.387000704508378 0.33582622898726 no 1134 0.349377843196361 397 2248285
SGTC_1740 st038286 13.222 µM 0.386551028080045 0.336009263596855 no 1135 0.349544309340499 346 716786
SGTC_2234 tolnaftate 200 µM 0.386522151262107 0.336021018838184 no 1136 0.349555000266292 403 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_2094 5332512 191.667 µM 0.385353911299746 0.336496723030215 no 1137 0.349987612125059 391 755774
SGTC_2625 euphol 100 µM 0.384700184570988 0.336763033106988 no 1138 0.350229779218342 403 6708538 A triterpene alcohol.
SGTC_1751 st044839 27.194 µM 0.383259506833766 0.337350213996584 no 1139 0.35076368002416 353 5291326
SGTC_2669 eugenol 100 µM 0.383052201758176 0.337434738534517 no 1140 0.350840529508833 393 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_3211 9128781 49.47 µM 0.382985518459264 0.337461929072715 no 1141 0.350865250785429 394 17194361
SGTC_3253 9135987 49.47 µM 0.382130394663271 0.337810686408386 no 1142 0.351182323900696 378 4182430
SGTC_403 arphamenine a 50 µM 0.379941250482784 0.338704150489719 no 1143 0.351994512930449 404 5487158 An arginine aminopeptidase inhibitor.
SGTC_2167 5876490 200 µM 0.376619383161244 0.340061651278956 no 1144 0.353228240517183 395 686534
SGTC_2456 5770359 74.46 µM 0.374803779495253 0.34080448714812 no 1145 0.353903201605588 418 3118787
SGTC_1881 5652484 16 µM 0.374802873448662 0.340804858002357 no 1146 0.353903538548471 396 2255129
SGTC_2122 5258151 111.688 µM 0.37430730854198 0.341007720889226 no 1147 0.354087847611225 367 2173356
SGTC_2723 salbutamol 83.58 µM 0.373508341110711 0.341334880468048 no 1148 0.354385069243241 395 9884233 β2-adrenoceptor agonist
SGTC_3070 9117005 49.47 µM 0.372253456578279 0.341848968795681 no 1149 0.354852074338975 382 8779016
SGTC_218 alverine citrate 93.75 µM 0.371051365046819 0.342341704606597 no 1150 0.355299637164085 405 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_2985 9022375 71.43 µM 0.370096499723066 0.342733294102298 no 1151 0.355655295031665 374 4939335
SGTC_3099 9120367 49.47 µM 0.368394901771662 0.34343153686413 no 1152 0.356289399190168 416 24824940
SGTC_2997 9067075 71.4286 µM 0.367371585484163 0.343851707548481 no 1153 0.356670931784052 421 27209819
SGTC_734 2023-0417 80 µM 0.366578080571182 0.344177651188252 no 1154 0.356966880419843 411 3935732
SGTC_1857 st056007 79.3 µM 0.36651115293764 0.344205147981763 no 1155 0.356991845946209 371 619834
SGTC_1444 4112-3581 28 µM 0.36610745688138 0.344371021407593 no 1156 0.357142446721943 375 2877249
SGTC_2792 7535235 81.82 µM 0.364437071749786 0.345057678708401 no 1157 0.357765828382857 366 1281891
SGTC_1834 st055981 52.8 µM 0.362366984996618 0.345909352470726 no 1158 0.358538903785918 401 471719 YDL150W RPC53
SGTC_8 0354-0001 70 µM 0.361051114719999 0.346451132876171 no 1159 0.359030618263906 392 4993152
SGTC_97 0535-0701 19.132 µM 0.359839239005384 0.346950373884656 no 1160 0.359483678762009 380 2832013 YGL099W LSG1
SGTC_2048 5246248 200 µM 0.358758091946684 0.347395984655061 no 1161 0.359888033075322 380 677046
SGTC_3039 9090270 49.47 µM 0.357896219691531 0.347751369256313 no 1162 0.360210489925157 388 17173750
SGTC_1 0258-0098 57.368 µM 0.35763952785102 0.347857239504472 no 1163 0.360306546644159 357 6790032 YDR047W HEM12
SGTC_3345 9148410 3.559 µM 0.356329356379602 0.348397792627286 no 1164 0.360796963502267 397 4903596
SGTC_822 1487-0950 154 µM 0.355336363000153 0.348807689072525 no 1165 0.361168808433446 394 1958375
SGTC_2882 9058044 58.44 µM 0.354978124081823 0.348955609405473 no 1166 0.361302989920117 366 18076804
SGTC_1645 Cervolide 78 µM 0.3539097011757 0.349396907868675 no 1167 0.361703278246044 406 23173 A fragrance.
SGTC_2546 rhodinyl acetate 100 µM 0.3529836117993 0.34977958207749 no 1168 0.362050363318269 376 6708682
SGTC_1000 4048-0884 8.67 µM 0.350907807169958 0.350637890208917 no 1169 0.362828757105173 402 13040088
SGTC_963 1269-2853 151 µM 0.35032837565892 0.350877611193211 no 1170 0.363046136111068 353 3668223
SGTC_2453 5731132 22.18 µM 0.348310198145399 0.351713029645108 no 1171 0.363803617901313 400 1362040
SGTC_2740 felodipine 17.08 µM 0.347778201802691 0.351933367422429 no 1172 0.364003380706482 422 3333 L-type calcium channel blocker
SGTC_2767 sibutramine 71.45 µM 0.347688692515134 0.351970444516991 no 1173 0.364036994771559 417 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_2486 5283202 22.39 µM 0.347584149437797 0.352013750783587 no 1174 0.364076255908024 385 1377751
SGTC_640 3381-0960 37.1 µM 0.347306798880285 0.352128650686718 no 1175 0.364180421779001 393 1745025
SGTC_3239 9133757 49.47 µM 0.34719517712586 0.352174896801377 no 1176 0.364222346925629 432 17036923
SGTC_2998 9066762 71.4286 µM 0.347075784138849 0.352224365042539 no 1177 0.364267192746736 421 4945196
SGTC_851 0394-0702 453 µM 0.345828746247453 0.352741201073815 no 1178 0.364735710106543 403 762646
SGTC_1547 harmine 94.2 µM 0.345551983450957 0.352855942578356 no 1179 0.364839718474684 390 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_628 1636-0253 16 µM 0.344353020936617 0.353353168053363 no 1180 0.365290407324675 395 4456143
SGTC_3121 9125696 49.47 µM 0.342737947691248 0.354023355838175 no 1181 0.365897805901069 418 1235365
SGTC_1512 0259-0544 12.2 µM 0.34222285799184 0.354237191768075 no 1182 0.366091592219955 397 18476
SGTC_1866 st057638 64 µM 0.34156341448045 0.354511022275817 no 1183 0.366339736985349 411 688802
SGTC_522 1273-0010 11.6 µM 0.339131499208549 0.355521511702132 no 1184 0.367255335033995 425 5705015
SGTC_1699 st031318 29.054 µM 0.338959503538044 0.355593016493157 no 1185 0.367320118786873 414 5340658
SGTC_2960 9079389 5.97 µM 0.338604894071107 0.35574045645121 no 1186 0.367453697626674 386 16457355
SGTC_2103 5378138 10 µM 0.338549017403039 0.355763690889637 no 1187 0.367474747429544 410 244142
SGTC_3222 9128301 49.47 µM 0.335834790758572 0.356892954705464 no 1188 0.3684977265452 400 4911358
SGTC_705 1124-0212 310 µM 0.3328368898969 0.358141700889725 no 1189 0.369628705102729 437 9554485
SGTC_732 3970-1727 52.7 µM 0.332788499677247 0.358161869853949 no 1190 0.369646969927049 425 1275699
SGTC_3095 9117207 49.47 µM 0.332744469773173 0.358180221789714 no 1191 0.369663589211603 401 17015229
SGTC_3165 9101544 49.47 µM 0.332105095652747 0.358446753775627 no 1192 0.369904951263109 407 5002184
SGTC_1439 4092-1168 46 µM 0.330337639324709 0.35918390102499 no 1193 0.370572427802658 418 2886240
SGTC_2457 5731572 11.68 µM 0.329988628654856 0.359329523868689 no 1194 0.370704277169295 417 2865357
SGTC_128 0906-2981 13.371 µM 0.327374721935819 0.360420810886161 no 1195 0.371692241504801 402 6740226
SGTC_977 1348-1378 135 µM 0.327132926436038 0.360521816384174 no 1196 0.371783674486053 419 X977
SGTC_1133 3473-0247 50 µM 0.326764368119843 0.360675793374376 no 1197 0.371923055697098 380 711311
SGTC_1462 k081-0014 26.5 µM 0.32624496732854 0.360892827965574 no 1198 0.372119510939328 377 3270634
SGTC_2420 aureobasidin a 50 nM 0.324426779426709 0.361652920683757 no 1199 0.372807474074651 363 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_381 3461-2219 42.7 µM 0.32403999573403 0.361814686008267 no 1200 0.372953877122438 418 2883159
SGTC_419 nsc-638432 893 µM 0.32325808816242 0.36214178018442 no 1201 0.373249896119492 379 368090
SGTC_1155 4088-0394 48.2 µM 0.323140267692987 0.362191076573564 no 1202 0.3732945077515 396 2326248
SGTC_2266 7929956 200 µM 0.32258479094398 0.362423520261205 no 1203 0.373504856760976 392 2967153
SGTC_991 3996-0057 64.7 µM 0.319510393269408 0.363710941776097 no 1204 0.374669755704202 368 715343
SGTC_1489 4065-0444 182 µM 0.319033370629586 0.363910836125885 no 1205 0.374850603929219 431 2877968
SGTC_1257 0669-0121 16 µM 0.318806048596872 0.364006107511363 no 1206 0.374936795659162 406 4307855
SGTC_2228 7354201 200 µM 0.318748278037511 0.364030320676023 no 1207 0.374958701018359 425 753451
SGTC_3221 9128209 49.47 µM 0.316929333677908 0.364792965372101 no 1208 0.375648611725452 400 16460723
SGTC_2373 9071805 200 µM 0.314426332925274 0.36584329504319 no 1209 0.37659862938809 414 10149009
SGTC_887 0885-0007 9.62 µM 0.314203253144416 0.36593695456584 no 1210 0.376683336032039 425 5719458
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.3131813024676 0.366366120225901 no 1211 0.377071461443631 448 688667
SGTC_5 0352-0601 109.883 µM 0.311040680982232 0.367265610224712 no 1212 0.377884847733884 398 762456
SGTC_2765 myclobutanil 7.74 µM 0.310178712451246 0.36762801588035 no 1213 0.378212528876699 429 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_1723 st034307 2.5525 µM 0.30854315528367 0.368315992669389 no 1214 0.378834533840352 394 867466
SGTC_776 4476-4378 112 µM 0.307991760312393 0.368548025436153 no 1215 0.379044301056467 406 2892008
SGTC_2051 5263410 176 µM 0.307681510599082 0.368678602838998 no 1216 0.379162345036377 396 227584
SGTC_48 0382-0018 55 µM 0.307551388274496 0.368733373029115 no 1217 0.379211857404159 359 762596
SGTC_2955 9076254 12.21 µM 0.307171113717774 0.368893450847505 no 1218 0.379356565633181 407 16459619
SGTC_1682 st012968 530 nM 0.306325158648255 0.369249639948891 no 1219 0.379678542750611 389 24207270
SGTC_1633 st005664 67.9 µM 0.305585383682438 0.3695612139934 no 1220 0.379960175290686 400 2063822
SGTC_2404 5161160 200 µM 0.305216599587049 0.369716568311424 no 1221 0.380100595292465 438 2831543
SGTC_1361 1608-0041 5.61 µM 0.305155396448078 0.369742352858932 no 1222 0.380123900823097 415 X1361
SGTC_2258 7960471 200 µM 0.305058549757922 0.369783155036107 no 1223 0.380160779943502 435 2974708
SGTC_928 2764-0428 58.7 µM 0.305028444588251 0.369795838850036 no 1224 0.38017224418328 396 662578
SGTC_674 0498-0004 451 µM 0.304941182680681 0.369832604558555 no 1225 0.380205474666584 399 4231473
SGTC_587 k089-0003 57 µM 0.304736111069499 0.369919011238877 no 1226 0.380283572116584 433 9659696
SGTC_2612 dictamnine 15.46 µM 0.304537208373425 0.370002824928137 no 1227 0.380359324920475 429 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_295 k015-0027 31 µM 0.303459101846311 0.370457225182995 no 1228 0.380770005424404 406 3887424
SGTC_2306 7482397 179.52 µM 0.303148829680873 0.370588032203849 no 1229 0.380888221568752 435 891448
SGTC_643 k048-0106 28.4 µM 0.302527087900106 0.370850196093037 no 1230 0.381125143551591 426 6763920
SGTC_2557 derrustone 83.84 µM 0.302126446167157 0.371019162625613 no 1231 0.381277836390949 415 629853 An antioxidant.
SGTC_2049 5262831 67.185 µM 0.301277864530338 0.371377125295792 no 1232 0.381601309387416 407 763417
SGTC_74 000s-0487 160.283 µM 0.301134040724991 0.371437806457162 no 1233 0.381656142153114 343 677548
SGTC_937 3122-0005 46.7 µM 0.301015283104229 0.371487914273118 no 1234 0.381701420236545 432 759535
SGTC_1990 st072050 59.8 µM 0.300559330641692 0.371680316106825 no 1235 0.381875273827233 389 17233948
SGTC_150 3970-0969 77.2 µM 0.300323494184316 0.371779846447104 no 1236 0.381965207059484 412 6615640
SGTC_503 tyrphostin 8 294 µM 0.299708997940612 0.372039223271193 no 1237 0.38219956729386 447 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_2442 5158906 48.48 µM 0.297718765708942 0.372879691801194 no 1238 0.382958909799832 428 1893835
SGTC_2474 5321570 43.32 µM 0.296960944287584 0.373199876678692 no 1239 0.383248163372159 450 2841384
SGTC_313 3474-0040 5.03 µM 0.29526636499625 0.373916164945366 no 1240 0.383895204262691 419 1043375 YIL048W NEO1
SGTC_1667 st014849 34.6 µM 0.293454970803226 0.374682311845767 no 1241 0.384587206605147 418 5348460
SGTC_1565 sinapyl alcohol 95.1 µM 0.290629721387056 0.375878265789778 no 1242 0.385667263204133 435 5280507 A phenol propionate derived from cinnamic acid.
SGTC_2129 girgensonine 121.053 µM 0.290499230871787 0.375933532536438 no 1243 0.38571716954933 446 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_237 nikkomycin 200 µM 0.290478743420578 0.375942209833325 no 1244 0.385725005185775 422 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_2684 capsaicin 100 µM 0.29014259378095 0.376084592292769 no 1245 0.385853575730154 431 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_1498 4478-3555 97.6 µM 0.289722198246748 0.376262682413066 no 1246 0.386014386298661 432 3437919
SGTC_3256 9138902 49.47 µM 0.288806685574719 0.376650607727139 no 1247 0.386364657838496 425 17228773
SGTC_1239 0337-0584 35.4 µM 0.288688003283508 0.376700905473702 no 1248 0.386410072003134 424 914301 YML130C ERO1
SGTC_3334 9142812 21.919 µM 0.287699119340107 0.377120077385307 no 1249 0.386788532099787 422 45283678
SGTC_1255 0566-0045 221 µM 0.287369905730082 0.377259657872059 no 1250 0.386914550789294 426 2788469
SGTC_1693 xanthone 101.9 µM 0.287333906168971 0.377274921993718 no 1251 0.386928331676607 435 7020 An insecticide.
SGTC_3065 9113888 49.47 µM 0.28659482493113 0.377588341101882 no 1252 0.38721128869756 414 16648368
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.286487367649593 0.377633916782486 no 1253 0.387252433678671 400 165521
SGTC_2375 9072683 200 µM 0.2861761433921 0.377765925427446 no 1254 0.387371607399024 436 16798029
SGTC_1329 1447-1697 50.6 µM 0.285332506878479 0.378123833414714 no 1255 0.38769470530868 396 2840515
SGTC_3278 9139605 49.47 µM 0.285028552705559 0.378252809894371 no 1256 0.387811133469682 411 7958859
SGTC_3023 9089636 49.47 µM 0.284531130799982 0.378463909549107 no 1257 0.388001690257466 407 17249241
SGTC_584 0986-0246 15.4 µM 0.284032020025275 0.378675762400453 no 1258 0.388192921141455 447 53315 YDR232W HEM1
SGTC_393 acivicin 6.25 µM 0.283263491468845 0.379002043761192 no 1259 0.388487430606058 421 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_2735 sertaconazole 140 nM 0.282364688556286 0.379383742922897 no 1260 0.388831944118102 419 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_603 3794-0023 45.9 µM 0.282200145901931 0.37945363282685 no 1261 0.388895023225887 416 3802260
SGTC_1984 st072354 53.1 µM 0.281324260319008 0.379825733663394 no 1262 0.389230852170568 432 5762938
SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.279978477406536 0.380397676877541 no 1263 0.389747008671356 408 5377381
SGTC_3034 9090421 49.47 µM 0.279690576128982 0.380520065819634 no 1264 0.389857454528196 433 17173761
SGTC_1651 st011928 86.1 µM 0.278140318061376 0.381179297185069 no 1265 0.390452323492016 423 720198
SGTC_3160 9100216 49.47 µM 0.278136476594327 0.381180931158824 no 1266 0.39045379786871 437 17191039
SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.275918603236834 0.382124659696067 no 1267 0.391305292518919 433 5282309
SGTC_101 0490-5701 117.494 µM 0.275207062066378 0.382427576722176 no 1268 0.391578580821154 441 4661669
SGTC_2394 5221648 200 µM 0.27516321942367 0.38244624375011 no 1269 0.391595421628628 427 788586
SGTC_3013 9080133 71.4286 µM 0.273347733075062 0.383219468793462 no 1270 0.392292963106308 401 17050193
SGTC_862 0452-0056 10.2 µM 0.272917583036413 0.383402740246028 no 1271 0.392458285060483 408 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_3343 9148379 18.9835 µM 0.27216539537875 0.383723283027367 no 1272 0.392747424149984 426 1955036
SGTC_707 0865-0008 204 µM 0.27094103845627 0.38424520960292 no 1273 0.393218190480816 445 723043
SGTC_1672 st016598 6.51 µM 0.270940550165325 0.384245417796603 no 1274 0.393218378260323 440 4665860 YNL267W PIK1
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.270618046681987 0.384382931608131 no 1275 0.393342407170594 439 551469
SGTC_2853 9015042 58.44 µM 0.2705911454618 0.384394402806581 no 1276 0.39335275337459 415 6457456
SGTC_1404 3909-7820 48.3 µM 0.268911107748764 0.385111003461947 no 1277 0.393999044488483 429 23741373
SGTC_2515 chrysin 20.77 µM 0.267378131281823 0.38576521943071 no 1278 0.394589017702088 399 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_989 1501-0895 10.3 µM 0.266122953320737 0.386301123723726 no 1279 0.395072259006083 450 2830112
SGTC_1832 st054113 55 µM 0.265962252181988 0.386369751540098 no 1280 0.395134140334398 435 1251267
SGTC_309 k408-0051 1.48 µM 0.264592482296667 0.386954859214059 no 1281 0.395661706025836 442 3640463
SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.263629647945573 0.387366295162193 no 1282 0.396032655359784 422 77254
SGTC_2975 9084847 53.72 µM 0.262765414141053 0.387735705161635 no 1283 0.396365697259466 396 27211724
SGTC_2657 nystatin 74.44 µM 0.260901473815616 0.388532777514841 no 1284 0.397084244129274 415 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_3046 9092212 49.47 µM 0.260288176154387 0.388795143369768 no 1285 0.397320746213334 437 25236637
SGTC_2411 st077133 39.94 µM 0.258716828020904 0.389467589942457 no 1286 0.397926867318844 462 1403142 YNL221C POP1
SGTC_356 1634-0012 32.5 µM 0.258542068322882 0.389542397531673 no 1287 0.39799429318708 451 735457
SGTC_339 3091-4833 71.4 µM 0.258472887273492 0.38957201228401 no 1288 0.398020985493663 427 3240077
SGTC_730 1436-0052 41.2 µM 0.257535102605636 0.389973518661321 no 1289 0.398382860461466 409 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_799 1310-0557 151 µM 0.255362874510844 0.390903994256256 no 1290 0.399221421130433 445 5354492
SGTC_1386 3228-0095 33.8 µM 0.254815112442581 0.391138727434441 no 1291 0.399432951222676 445 870181
SGTC_2544 sphondin 68.51 µM 0.254745067060475 0.391168746933205 no 1292 0.39946000288257 411 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_1959 st077091 55.8 µM 0.254255089715664 0.391378755689815 no 1293 0.399649246557019 425 821356 YKL052C ASK1
SGTC_2648 atorvastatin 78.68 µM 0.254073670687825 0.391456521575434 no 1294 0.399719321909422 450 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_939 1165-0479 45.3 µM 0.251866971760423 0.39240277705467 no 1295 0.400571944725871 448 1377347
SGTC_1527 coumarin 137 µM 0.249505532659916 0.393416091694692 no 1296 0.401484880882427 465 323 A hepatotoxic, DNA x-linker.
SGTC_489 paxilline 115 µM 0.248938994623935 0.393659305935371 no 1297 0.401703985606183 431 105008 A toxic potassium channel blocker.
SGTC_85 0868-0259 160.055 µM 0.248063267049385 0.394035336559653 no 1298 0.402042728056621 439 83173
SGTC_759 3486-0358 89.3 µM 0.247954872415409 0.394081887253103 no 1299 0.402084661589017 451 875103
SGTC_1463 k081-0032 34.1 µM 0.246657032041173 0.394639369544843 no 1300 0.402586831331692 436 977755
SGTC_2466 5983409 37.09 µM 0.246411012038196 0.394745070850589 no 1301 0.402682041314521 442 2879657
SGTC_257 daunorubicin 18.5 µM 0.245226924578674 0.395253916570275 no 1302 0.403140364971825 440 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1187 1391-0724 117 µM 0.245217678996778 0.395257890439275 no 1303 0.4031439441753 424 6997986
SGTC_861 0443-0273 110 µM 0.2442101028956 0.395691024688462 no 1304 0.403534051467094 439 6149169
SGTC_1730 st033808 45.1 µM 0.243478603236917 0.396005560662717 no 1305 0.40381732930217 463 1045166
SGTC_130 0136-0219 337.655 µM 0.24292596967551 0.396243231304719 no 1306 0.404031373585066 465 234244
SGTC_3138 9097216 49.47 µM 0.241847195007606 0.396707290052202 no 1307 0.404449283921242 457 25237486
SGTC_2994 9053520 71.4286 µM 0.241470036814766 0.396869567535669 no 1308 0.404595418318432 449 4647384
SGTC_289 k017-0060 526 µM 0.239034183419586 0.397918055857208 no 1309 0.405539538189408 458 5512909
SGTC_1367 1812-0510 76.9 µM 0.237975375214202 0.398374039551542 no 1310 0.405950096668885 411 1142582 YDR527W RBA50
SGTC_3262 9137218 49.47 µM 0.237176693142137 0.398718089848882 no 1311 0.406259858344969 439 17650664
SGTC_2102 5377816 72.7585 µM 0.236408408429252 0.399049120088766 no 1312 0.406557886055898 451 1379702
SGTC_1305 1181-0477 144 µM 0.235392100538519 0.399487127412942 no 1313 0.406952208352036 422 6252086
SGTC_2270 7924575 90.91 µM 0.234629073975736 0.39981605901065 no 1314 0.407248320807742 435 1262135
SGTC_212 3807-4682 38.772 µM 0.233311908215274 0.400384040562882 no 1315 0.40775960616279 428 3125501 YBL034C STU1
SGTC_2256 7954252 200 µM 0.232995747819917 0.40052040505525 no 1316 0.40788235383148 441 2972920
SGTC_2160 5660466 132.927 µM 0.231913728943428 0.400987186912096 no 1317 0.40830251052568 456 2859134
SGTC_1780 st038448 24.544 µM 0.231454498678666 0.401185341163356 no 1318 0.408480865257867 439 728868 YDL195W SEC31
SGTC_2332 7982454 138.89 µM 0.231182184909259 0.401302854424573 no 1319 0.408586634773056 468 2981748
SGTC_1803 st050068 52.4 µM 0.231143390610519 0.401319596297339 no 1320 0.408601703426356 452 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_305 1682-2595 20.8 µM 0.231135902430121 0.401322827879732 no 1321 0.408604612034103 445 226033
SGTC_873 0591-4978 488 µM 0.230096153978029 0.401771604839641 no 1322 0.409008526702093 471 3305145
SGTC_2937 9044753 11.33 µM 0.230007188309555 0.401810010289797 no 1323 0.409043091996561 434 6465530 YGL099W LSG1
SGTC_2580 diallyl disulphide 81.36 µM 0.229797648820086 0.401900469810244 no 1324 0.409124505904655 436 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_1250 0485-0349 40.2 µM 0.228939760513383 0.402270880365611 no 1325 0.409457868358738 436 6842794 YDL195W SEC31
SGTC_3005 9076496 71.4286 µM 0.228244147131705 0.402571289911373 no 1326 0.409728221308565 447 21368410
SGTC_2809 7964133 12.99 µM 0.227093709119202 0.403068247492513 no 1327 0.410175437833594 456 1253665
SGTC_815 1582-0027 36.9 µM 0.226290124212043 0.403415467024115 no 1328 0.410487889465708 442 3128206
SGTC_1790 st045711 43.5 µM 0.2257648601155 0.403642468599538 no 1329 0.410692154516563 434 585119
SGTC_1446 4239-0190 62 µM 0.224692519674779 0.404105998984046 no 1330 0.411109242131066 458 1340085
SGTC_2518 prenyletin 46.28 µM 0.223514918368214 0.404615184613123 no 1331 0.411567386811771 456 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_2320 7373003 200 µM 0.223491014105519 0.404625522306183 no 1332 0.411576687993663 418 5415828
SGTC_234 nsc-17383 10.7 µM 0.223474686264973 0.404632583520363 no 1333 0.411583041207713 447 408974
SGTC_3115 9123671 49.47 µM 0.223457422492432 0.404640049525845 no 1334 0.411589758621055 452 3286988
SGTC_2014 4013930 200 µM 0.223407652497563 0.404661573581975 no 1335 0.411609124500132 461 64556
SGTC_670 4204-0025 119 µM 0.2218155243088 0.40535027399568 no 1336 0.412228746918883 470 719039
SGTC_2843 9000894 45.46 µM 0.219328244783198 0.406426772392142 no 1337 0.413197180668747 423 2242070
SGTC_2368 9071271 200 µM 0.218879786663914 0.406620941286019 no 1338 0.413371846300679 452 27209959
SGTC_2525 harmine 47.85 µM 0.217729664553447 0.407119014451993 no 1339 0.41381987457217 465 5280953 A monoamine oxidase inhibitor
SGTC_810 3825-7150 143 µM 0.217647371469844 0.407154658155558 no 1340 0.413851936022571 427 22330411 YGL099W LSG1
SGTC_966 1300-0360 30.2 µM 0.217355001937276 0.407281298743989 no 1341 0.413965848066368 456 70588
SGTC_2885 9057732 51.95 µM 0.217241921094145 0.407330282591846 no 1342 0.414009908189872 438 6471414
SGTC_2319 6033012 152.6 µM 0.216773010784856 0.407533418493512 no 1343 0.414192623059793 427 847246
SGTC_3151 9099821 49.47 µM 0.216618609893228 0.407600311706883 no 1344 0.414252790740397 426 17174189
SGTC_2397 5161689 200 µM 0.216528985484814 0.407639142153046 no 1345 0.414287716933267 437 2259942
SGTC_2751 anetholtrithion 17.25 µM 0.216064346741913 0.407840464906515 no 1346 0.41446879523446 446 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_3118 9124250 49.47 µM 0.21601482201301 0.407861924852006 no 1347 0.414488097008953 465 1504786
SGTC_446 go6976 132 µM 0.21576150338386 0.407971696639399 no 1348 0.414586828673883 474 3501 A protein kinase C inhibitor.
SGTC_3332 9141069 11.198 µM 0.215194526431425 0.408217413672558 no 1349 0.414807829120235 437 17332883
SGTC_2768 sulfasalazine 50.2 µM 0.214898085352077 0.408345899977136 no 1350 0.414923388843929 442 5384001 An antioxidant and salicylic acid derivative.
SGTC_2409 alverine citrate 63.97 µM 0.214832994049059 0.40837411378702 no 1351 0.414948763954952 378 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_1513 0337-0559 19 µM 0.213321094893239 0.409029579464911 no 1352 0.41553826043216 427 775073
SGTC_760 0568-0725 82.9 µM 0.212995034889602 0.409170972273905 no 1353 0.415665417707261 473 3916171
SGTC_1443 4112-3303 14 µM 0.211882702554009 0.409653413397722 no 1354 0.416099272792864 463 704433
SGTC_2516 gossypol 71.55 µM 0.211730688533837 0.409719355609162 no 1355 0.41615857242973 440 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1201 1889-3372 45.9 µM 0.211392449855682 0.409866089436147 no 1356 0.416290523887149 441 5392199
SGTC_332 4112-0506 40.9 µM 0.210215602943141 0.410376724358472 no 1357 0.416749701125566 468 2790355
SGTC_1288 0973-0013 65.5 µM 0.210068124718924 0.410440726024882 no 1358 0.416807251589522 436 4315430
SGTC_324 1315-0088 19.6 µM 0.209738489878961 0.410583787487709 no 1359 0.41693589151929 470 6787421
SGTC_1057 3448-5381 134 µM 0.209680067338231 0.410609144101874 no 1360 0.416958691832261 448 5497911
SGTC_1629 st005085 44.9 µM 0.209154411147135 0.410837306761004 no 1361 0.417163849959806 483 24207091
SGTC_1084 voriconazole 435 nM 0.208174003075542 0.41126293640765 no 1362 0.417546553229981 482 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_953 1188-0045 9.7 µM 0.207787902740062 0.41143058485118 no 1363 0.417697289340368 457 6144426
SGTC_3148 9097893 49.47 µM 0.207449245580893 0.411577646331136 no 1364 0.417829513279248 417 17174100
SGTC_733 4069-0007 56.1 µM 0.206808013984868 0.411856134424684 no 1365 0.418079898599341 463 5717425 YNL287W SEC21
SGTC_3337 9144342 33.5465 µM 0.20675845501963 0.411877659827151 no 1366 0.418099251551829 439 17682949
SGTC_1188 1403-0014 4.57 µM 0.206588191176486 0.411951614112575 no 1367 0.418165741699862 450 9614867
SGTC_334 1502-1024 68.5 µM 0.206455681366981 0.412009172056591 no 1368 0.418217490046764 461 3296216
SGTC_1769 st044406 64.4 µM 0.205446799937727 0.412447459265264 no 1369 0.418611529472551 479 670903
SGTC_2519 cryptotanshinone 88.04 µM 0.205299565408962 0.412511431337651 no 1370 0.418669041790097 434 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_2241 6772625 37.8075 µM 0.201918502654121 0.413981108738421 no 1371 0.41999021848553 479 2285411
SGTC_537 1334-0398 209 µM 0.199860395175947 0.414876316709814 no 1372 0.420794882769339 453 5846986
SGTC_3004 9076122 71.4286 µM 0.199427013539474 0.415064879757171 no 1373 0.42096436555672 467 44782551
SGTC_271 rotenone 740 µM 0.198844581102497 0.415318325171998 no 1374 0.421192160786641 460 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_2891 9063876 19.48 µM 0.198751591160211 0.415358793000734 no 1375 0.42122853254 463 6472478
SGTC_1887 st057648 70.8 µM 0.198619878931256 0.415416113724532 no 1376 0.42128005114036 461 688672
SGTC_1210 3013-0140 750 nM 0.198253796692401 0.415575440947998 no 1377 0.421423249511053 455 905973
SGTC_3294 9122953 26.2835 µM 0.197319135487817 0.415982289426958 no 1378 0.421788902879657 477 16459826
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.196889777732946 0.416169214687535 no 1379 0.421956896646208 454 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_1707 st032323 6.317 µM 0.196106347033414 0.4165103380432 no 1380 0.42226346425242 447 3132057 YMR211W DML1
SGTC_1801 st050089 28.441 µM 0.194379124518158 0.417262631406178 no 1381 0.422939517200884 421 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_1561 5-methoxyflavone 52.9 µM 0.193561822801007 0.417618713701675 no 1382 0.423259496880701 473 94525
SGTC_2347 9049783 174.81 µM 0.19346858689763 0.41765933905103 no 1383 0.423296002648722 462 6467988 YPL169C MEX67
SGTC_342 k048-0088 23.3 µM 0.193108720852007 0.417816150444604 no 1384 0.423436911477448 451 6820570
SGTC_3178 9107506 49.47 µM 0.192726659503067 0.417982647728474 no 1385 0.42358652179614 456 8897194
SGTC_2136 5328288 199.296 µM 0.191754000338754 0.418406586015784 no 1386 0.423967452311387 445 262395
SGTC_2287 7945887 168.79 µM 0.19134269735222 0.418585882995711 no 1387 0.424128555681838 456 1245853
SGTC_2848 9016370 25.97 µM 0.190558861551194 0.418927622899528 no 1388 0.42443561160864 471 7894410
SGTC_2861 9024595 19.48 µM 0.190005159156178 0.419169065200401 no 1389 0.424652543877999 467 16482810
SGTC_55 0767-0285 6.563 µM 0.18930663873697 0.419473698913911 no 1390 0.424926246221525 477 3116166
SGTC_930 2810-3379 265 µM 0.189203490267249 0.41951868737911 no 1391 0.424966666117186 457 1015764
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.188623942583798 0.419771478107225 no 1392 0.425193783093826 458 17037758
SGTC_2772 vinpocetine 57.06 µM 0.188294731420918 0.419915090240505 no 1393 0.425322807602873 481 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_757 1066-0008 322 µM 0.18786903593542 0.420100807640698 no 1394 0.425489658124233 445 6842497
SGTC_2176 5809774 33.9695 µM 0.187103941840506 0.420434638557432 no 1395 0.425789568798434 483 2870539
SGTC_1073 triclabendazole 3.09 µM 0.186574645769788 0.420665618030971 no 1396 0.425997073697628 438 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_265 mycophenolic acid 32.932 µM 0.184355791682449 0.421634199994968 no 1397 0.426867174230295 463 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_170 4197-0004 226 µM 0.184043451324718 0.421770582120376 no 1398 0.426989683928512 446 218692
SGTC_1291 0993-0025 5.79 µM 0.183379971908969 0.422060318780378 no 1399 0.427249944748536 461 4353356
SGTC_721 1187-1332 279 µM 0.180903103919068 0.423142320606275 no 1400 0.42822181623822 478 25730
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.180385383255804 0.423368556677208 no 1401 0.428425014288651 479 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_3202 9113761 49.47 µM 0.179223442723848 0.423876398934472 no 1402 0.428881128552927 476 4798415
SGTC_1906 st060206 94.7 µM 0.179170906614283 0.423899363565444 no 1403 0.428901753603565 466 5133468
SGTC_2588 indole-3-carbinol 100 µM 0.179138678857944 0.423913451118876 no 1404 0.428914405932784 480 3712 Induces cell cycle arrest.
SGTC_1014 4130-3005 69.3 µM 0.178916874648242 0.424010409889194 no 1405 0.429001486264601 441 743608
SGTC_1500 4488-1866 171 µM 0.178427672598182 0.42422427433404 no 1406 0.429193559197914 493 2900003
SGTC_2091 4-phenylthiadiazole 200 µM 0.177765292548908 0.424513882550519 no 1407 0.429453652846832 450 270010
SGTC_1387 3342-1166 1.8 µM 0.177038287786219 0.424831793130764 no 1408 0.429739157628271 454 3418228
SGTC_1479 0549-0158 134 µM 0.17574269911157 0.42539845981285 no 1409 0.430248044146779 443 5440202
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.175723541822796 0.425406840018308 no 1410 0.43025556969499 483 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_1424 4048-1941 275 µM 0.17570993820664 0.425412790833775 no 1411 0.430260913612134 488 X1424
SGTC_204 PMA1.184 62.41 µM 0.175478157144792 0.425514184596831 no 1412 0.430351966275462 454 2252213 YGL008C PMA1
SGTC_2934 9036370 36.88 µM 0.173350450435868 0.426445189673858 no 1413 0.431187985095993 467 6462800
SGTC_2622 2-methoxyxanthone 59.94 µM 0.171062581903649 0.427446732958081 no 1414 0.432087278730135 473 71034 A hepatoprotective.
SGTC_2872 9044037 25.97 µM 0.170038451335451 0.427895210967261 no 1415 0.432489948578145 454 6465195
SGTC_3311 9131146 2.8755 µM 0.167940931962754 0.428814027908848 no 1416 0.433314874182031 455 4900406 YPR165W RHO1
SGTC_39 0986-0283 58.349 µM 0.167009963093631 0.42922196214643 no 1417 0.433681104806898 450 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_1946 st076057 65.1 µM 0.166941078525045 0.429252149166013 no 1418 0.433708205335654 480 953009
SGTC_3320 9137005 35.139 µM 0.166799603182196 0.429314148658746 no 1419 0.433763865463726 485 4908713
SGTC_351 caspofungin 25 nM 0.166684541038419 0.429364574240492 no 1420 0.433809134911824 452 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_1775 st081588 35.1725 µM 0.165675666635795 0.429806759185624 no 1421 0.434206098296987 471 1426443 YGL099W LSG1
SGTC_2436 5633522 8.09 µM 0.165175452630286 0.430026033342912 no 1422 0.434402942913064 459 5724242
SGTC_2419 paclitaxel 166.5 µM 0.164541123111327 0.430304129501025 no 1423 0.434652588157628 479 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1321 1326-2144 215 µM 0.16426876746245 0.430423543452495 no 1424 0.434759783812578 486 3513030
SGTC_1043 0916-0009 19.3 µM 0.163822404685669 0.430619264339502 no 1425 0.434935476786231 492 3101130
SGTC_1935 st074532 41.6 µM 0.163773207143772 0.430640837492314 no 1426 0.434954842230739 497 2829742
SGTC_1230 0170-0365 3.77 µM 0.163494640540034 0.43076299302412 no 1427 0.435064496303294 474 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_589 1227-0070 34.1 µM 0.163337510755205 0.430831899656986 no 1428 0.43512635057597 471 2841384
SGTC_2384 9036245 200 µM 0.162708452853311 0.431107783523216 no 1429 0.435373995635838 491 6462766
SGTC_136 0097-0015 404.482 µM 0.161710230229929 0.43154563970102 no 1430 0.435767024011547 445 4861337
SGTC_1067 clotrimazole 1.36 µM 0.159600383961885 0.432471369974574 no 1431 0.436597938250515 472 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1431 4049-0260 9.09 µM 0.159509582254781 0.432511219098479 no 1432 0.436633704713144 478 3854841
SGTC_3022 9087993 49.47 µM 0.159185812773598 0.43265331375405 no 1433 0.436761240550567 496 17173644
SGTC_86 0417-1630 471.922 µM 0.159178785413811 0.432656397990259 no 1434 0.436764008766475 452 3634867
SGTC_23 0213-0011 39.996 µM 0.158840332848297 0.432804946207458 no 1435 0.436897335584617 460 627608
SGTC_718 1130-0073 349 µM 0.15816220652028 0.433102607185031 no 1436 0.437164491840958 472 6740020
SGTC_1837 st055472 66.5 µM 0.158060501286212 0.433147253588884 no 1437 0.437204562350215 448 676091
SGTC_397 arbidol 50 µM 0.157674232709361 0.433316824931255 no 1438 0.437356752896603 473 131410 A RNA synthesis inhibitor.
SGTC_2731 amoxapine 43.43 µM 0.157177445401642 0.433534931879758 no 1439 0.43755250165491 498 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_2511 berberine 10.47 µM 0.157137053181001 0.433552666363595 no 1440 0.437568418046157 448 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2449 5812982 45.77 µM 0.154569227385959 0.434680361128815 no 1441 0.438580465686067 482 776185
SGTC_2909 7941780 10.49 µM 0.153232860876898 0.435267455127791 no 1442 0.439107322219054 474 1243215
SGTC_3112 9123419 49.47 µM 0.152785489679356 0.435464026683547 no 1443 0.439283720469313 488 17015854
SGTC_1800 st050079 29.0735 µM 0.152468468052854 0.435603333270904 no 1444 0.439408729247373 480 3645560
SGTC_2886 9058944 51.95 µM 0.150460207241206 0.436485994171457 no 1445 0.440200771657461 479 4949929
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.15026232689197 0.4365729827603 no 1446 0.440278827130063 436 16623 A steroid.
SGTC_347 4534-1311 26.2 µM 0.14998326200958 0.436695665441131 no 1447 0.440388910429308 472 2862016
SGTC_2039 Aminomethylbenzodioxan 200 µM 0.149799415518408 0.436776491480141 no 1448 0.440461435251693 465 15053
SGTC_225 nsc-122657 1.016 µM 0.148012212041711 0.437562352397453 no 1449 0.441166565291631 486 275685
SGTC_1804 st050076 49.1 µM 0.147879604847767 0.437620671680785 no 1450 0.441218892098501 482 3895976
SGTC_1550 gossypolone 36.6 µM 0.147334083520354 0.437860600604257 no 1451 0.441434165631485 472 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2664 lyso-paf C-16 73.48 µM 0.145958022781378 0.438465915227206 no 1452 0.441977263215412 468 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_748 act1.228 77.9 µM 0.145822473427009 0.438525549772842 no 1453 0.442030767155446 450 4421505 YNR035C ARC35
SGTC_1824 st053723 68.6 µM 0.145189038012197 0.43880424632761 no 1454 0.442280810312889 470 675225
SGTC_2120 5538279 151.968 µM 0.145002779173297 0.43888620157708 no 1455 0.442354338760036 477 2058197
SGTC_1284 0929-0043 16 µM 0.144841325474285 0.438957244503961 no 1456 0.442418076616129 481 1239883
SGTC_3303 9125618 40.5795 µM 0.144095016468786 0.439285661236094 no 1457 0.442712719968165 474 22695467
SGTC_2426 5582046 32.21 µM 0.143865347088164 0.439386736730628 no 1458 0.442803399994628 458 2251934
SGTC_833 3852-0053 558 µM 0.143016494000131 0.439760343826302 no 1459 0.443138577386181 463 3123681
SGTC_2929 9013348 24.6 µM 0.142962955769422 0.439783909497373 no 1460 0.443159718812057 473 2995952
SGTC_423 5-fluorouracil 457 µM 0.142762887262184 0.439871974598408 no 1461 0.443238724227662 472 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1068 loratadine 26.9 µM 0.142614067144627 0.439937483383209 no 1462 0.443297493537495 480 3957 A H1 histamine antagonist.
SGTC_2026 5148700 152 µM 0.142213176721324 0.440113958591464 no 1463 0.443455812028784 463 79838
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.14119900593398 0.440560457822354 no 1464 0.443856365679126 476 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_2121 5257820 149.641 µM 0.140866956099687 0.440706662665823 no 1465 0.443987523504562 502 791256
SGTC_984 1492-0255 2.91 µM 0.139562584122758 0.441281068671536 no 1466 0.444502802383505 493 1585198
SGTC_2271 7849410 118.62 µM 0.139141500157916 0.441466527761753 no 1467 0.444669167391695 492 972430
SGTC_2949 9072542 2.23 µM 0.138278512273697 0.441846655790646 no 1468 0.445010153539876 457 16457352
SGTC_2747 doxorubicin 7.63 µM 0.137607676221962 0.442142181994465 no 1469 0.445275244250769 508 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_768 0384-0033 77.3 µM 0.1373898611171 0.442238143924708 no 1470 0.445361322354691 457 3965305 YMR134W ERG29
SGTC_2916 7875993 68.79 µM 0.133955196353775 0.443751784974893 no 1471 0.446719001584336 491 1299250
SGTC_2742 clothiapine 36.27 µM 0.133729583759169 0.443851240387986 no 1472 0.446808205409105 494 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_451 chloral hydrate 100 µM 0.133708046197609 0.443860734843852 no 1473 0.446816721177636 493 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_278 4092-0821 23.9 µM 0.133427767585525 0.443984293685116 no 1474 0.44692754319002 481 877900
SGTC_292 k038-0015 474 µM 0.13266823886451 0.444319153879813 no 1475 0.447227881246333 467 46368540
SGTC_354 2783-3500 4.88 µM 0.132172298085012 0.444537825176342 no 1476 0.447424005894357 475 6740761
SGTC_2795 7780010 54.55 µM 0.131543329532922 0.444815175643571 no 1477 0.447672756165943 463 953673
SGTC_617 3770-0098 35 µM 0.130311449186413 0.445358464728182 no 1478 0.448160011084102 487 5962639
SGTC_2920 7982904 15.77 µM 0.129934593725591 0.44552468766754 no 1479 0.448309087224008 485 6456808
SGTC_1134 3477-0009 42.5 µM 0.129484763801004 0.445723110628389 no 1480 0.448487040091185 496 3973534
SGTC_2598 perillyl alcohol 100 µM 0.129361833550268 0.445777338344138 no 1481 0.44853567314398 474 10819 An apoptosis inducer.
SGTC_1594 piperine 70.1 µM 0.128812482876457 0.446019683527532 no 1482 0.448753013958418 498 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_264 promethazine 12.5 mM 0.127875777531882 0.446432956076132 no 1483 0.449123640188582 499 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_1448 4255-0083 152 µM 0.126414970894908 0.447077577054388 no 1484 0.449701726080427 487 5399660
SGTC_3051 9093778 49.47 µM 0.126380878446909 0.447092622958235 no 1485 0.449715218785069 496 17217378
SGTC_3251 9135047 49.47 µM 0.126016143780887 0.447253594825703 no 1486 0.449859572779282 490 17682963
SGTC_2752 diclazuril 33.15 µM 0.125214074256624 0.447607610430838 no 1487 0.450177037645721 470 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_223 busulfan 5 mM 0.125086924865632 0.447663735177331 no 1488 0.450227367219113 494 2478 A DNA alkylator.
SGTC_2919 7978188 46.38 µM 0.124964320522566 0.447717854696107 no 1489 0.450275898483197 488 2980291
SGTC_1052 3253-3998 198 µM 0.124944334512116 0.447726676933196 no 1490 0.450283809744503 470 5450317
SGTC_839 0122-0028 230 µM 0.124856577942123 0.447765414798579 no 1491 0.450318547534238 502 759448
SGTC_1145 3546-0597 10.2 µM 0.123551174101911 0.448341710146232 no 1492 0.450835326795985 473 875334
SGTC_845 0330-0138 4.51 µM 0.121906527155949 0.449067925888045 no 1493 0.451486523131929 507 9039800
SGTC_668 1682-0499 62.6 µM 0.120965588629604 0.449483486721 no 1494 0.45185914564646 491 682214
SGTC_1910 st062352 60.4 µM 0.120853528221353 0.449532981345906 no 1495 0.451903525694098 482 2245730
SGTC_2677 mitomycin C 100 µM 0.120213754170047 0.449815570529316 no 1496 0.452156911268942 490 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_3316 9136639 10.545 µM 0.119587418277983 0.450092248712731 no 1497 0.452404993476019 502 4903665
SGTC_974 1326-0144 138 µM 0.118913400566961 0.45039001700273 no 1498 0.452671982488583 492 5411856
SGTC_2850 9015429 58.44 µM 0.118470289501306 0.450585790325424 no 1499 0.452847517414794 500 6457570
SGTC_804 1595-0054 20.9 µM 0.117481943494437 0.451022500126269 no 1500 0.453239075977793 477 761523 Stimulates phospholipase C.
SGTC_231 b-estradiol 524 µM 0.117357345107445 0.451077559292492 no 1501 0.453288442052453 500 450 A steroid.
SGTC_1324 1418-0026 34.4 µM 0.116875717454894 0.451290396066214 no 1502 0.453479270458531 482 1372513
SGTC_2257 7960413 200 µM 0.115674194862973 0.451821423569697 no 1503 0.453955379226773 491 2974689 YIL048W NEO1
SGTC_1226 3909-7979 35.4 µM 0.115580283115225 0.45186293265211 no 1504 0.453992594979229 510 6615510
SGTC_82 0054-0107 293.755 µM 0.114767306046302 0.452222291243208 no 1505 0.454314781888845 506 3104697
SGTC_274 sirtinol 40.1 µM 0.113861156635323 0.452622880732872 no 1506 0.454673928885642 472 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_1064 honokiol 6.76 µM 0.113197562131412 0.452916272442682 no 1507 0.454936964191773 499 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_2710 st078562 53.7235 µM 0.112899888443936 0.453047889778532 no 1508 0.455054962387522 504 17250908
SGTC_2824 7998404 51.95 µM 0.112566917099309 0.453195120193366 no 1509 0.455186957314028 493 837851
SGTC_897 1000-0139 31.4 µM 0.112391951976406 0.453272487351553 no 1510 0.455256318144816 501 6151020
SGTC_2414 st077232 92.9 µM 0.111359586629887 0.45372902104402 no 1511 0.455665602938336 480 729801
SGTC_701 4424-0219 185 µM 0.111043916934334 0.453868629065283 no 1512 0.455790760689077 473 2911779
SGTC_3057 9095946 49.47 µM 0.109683277234875 0.454470450350104 no 1513 0.456330281611027 502 24540043
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.109360318019511 0.454613313068984 no 1514 0.456458353276974 486 4000243
SGTC_2556 citropten 84.59 µM 0.107365603405586 0.455495815056302 no 1515 0.457249470621025 459 2775 A potential DNA crosslinker.
SGTC_1231 0242-0792 125 µM 0.107189333789403 0.455573810916586 no 1516 0.457319388540204 493 3707635
SGTC_2689 tacrolimus 100 µM 0.106119707914406 0.456047136074503 no 1517 0.457743687390704 512 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_484 loperamide 105 µM 0.105058703007262 0.456516707960882 no 1518 0.458164614063183 484 3955 An opioid-receptor agonist.
SGTC_2134 5324836 1.464 µM 0.103953240344085 0.457006020232196 no 1519 0.458603228123793 523 699272
SGTC_3031 9088762 49.47 µM 0.103072847073166 0.457395756436435 no 1520 0.45895257755825 471 205253
SGTC_1591 genipin 88.4 µM 0.102332969584536 0.457723320225393 no 1521 0.459246193360339 507 442424 A DNA cross-linking agent.
SGTC_663 1486-0733 13.9 µM 0.101987472224138 0.457876291107828 no 1522 0.459383309473713 487 722445 YPR165W RHO1
SGTC_1046 2001-0062 216 µM 0.101620268436557 0.45803887947171 no 1523 0.459529045423427 499 739778
SGTC_899 1083-0020 478 µM 0.100603979032587 0.458488902727316 no 1524 0.459932418962022 509 767123
SGTC_2153 5569715 200 µM 0.0991165110134137 0.459147664429959 no 1525 0.460522881373815 502 2054701
SGTC_1567 st069303 68.4 µM 0.0984873001970687 0.45942635974724 no 1526 0.460772677953117 505 5581319
SGTC_1752 st044819 83.042 µM 0.0981992117011015 0.459553968976329 no 1527 0.460887054205802 488 441209 YML126C ERG13
SGTC_1302 1159-0335 255 µM 0.0981107598819688 0.459593149678277 no 1528 0.460922171799612 496 649284
SGTC_1664 st014217 9.02 µM 0.0980720600513687 0.459610292315487 no 1529 0.460937536700225 506 3982782
SGTC_2910 7948405 25.97 µM 0.0973869065040674 0.459913803171681 no 1530 0.461209571198803 511 2971328
SGTC_1662 st014054 52 µM 0.0969391958203695 0.460112143686167 no 1531 0.461387340803765 503 2838777
SGTC_1939 st074455 53.6 µM 0.0929555974064291 0.46187735082454 no 1532 0.462969418281053 524 1644229
SGTC_3172 9105863 49.47 µM 0.0917872708364357 0.462395202252329 no 1533 0.463433528883605 509 2348785
SGTC_1518 st038567 90.8 µM 0.0917713230206586 0.462402271437402 no 1534 0.463439864401901 513 77966
SGTC_1950 st077106 7.18 µM 0.0910662504724533 0.462714820640095 no 1535 0.463719974701221 459 13831864
SGTC_1449 4112-4002 201 µM 0.0908243808510099 0.462822043511571 no 1536 0.463816068498146 491 2059539
SGTC_1650 st011916 45.8 µM 0.0898496796917013 0.463254164168313 no 1537 0.4642033345614 507 242528
SGTC_1609 st001574 46.4 µM 0.0886693560716566 0.463777502778951 no 1538 0.464672343446282 522 3960012
SGTC_525 k781-2675 26.7 µM 0.0881345542338588 0.464014646954475 no 1539 0.464884866460303 506 3651118 YDL195W SEC31
SGTC_440 fluspirilene 35.1 µM 0.0880531884382989 0.464050727654906 no 1540 0.464917201005976 504 3396 An atypical antipsychotic.
SGTC_1870 st057514 26.5 µM 0.086134068619062 0.46490182373794 no 1541 0.465679920705014 506 5393161
SGTC_1802 st050112 57.9 µM 0.0858019428621333 0.465049132114183 no 1542 0.465811930997952 503 4662563
SGTC_638 3970-0837 4.09 µM 0.0858006805934334 0.465049691979799 no 1543 0.465812432720098 501 4118451 YLR208W SEC13
SGTC_3305 9127027 53.8275 µM 0.0852874073263542 0.465277354502027 no 1544 0.466016451276381 496 41905295
SGTC_528 3492-0019 172 µM 0.0838081396942909 0.465933547454751 no 1545 0.466604488125409 518 2869262
SGTC_1428 4049-0204 61.7 µM 0.0833074710165619 0.466155661708129 no 1546 0.466803529967308 508 X1428
SGTC_881 0833-0569 170 µM 0.0821884323364568 0.466652144677615 no 1547 0.467248435991204 485 5418700
SGTC_1742 st038235 28.8875 µM 0.0818092241112681 0.466820399489538 no 1548 0.467399210442178 516 564103 YBR002C RER2
SGTC_938 3126-1755 342 µM 0.0806419631951738 0.467338350620863 no 1549 0.467863346528008 509 1777771
SGTC_1347 1493-0251 600 nM 0.079750307723152 0.467734044078676 no 1550 0.468217923531529 512 3986378
SGTC_3249 9135183 49.47 µM 0.0793952875097423 0.467891601692433 no 1551 0.468359108416665 509 4902779
SGTC_1398 3558-0053 112 µM 0.0793602178516142 0.46790716584483 no 1552 0.468373055178695 494 4532369
SGTC_2041 5107442 45.335 µM 0.0792779119381039 0.467943693960732 no 1553 0.468405787357904 502 793005
SGTC_26 0302-0163 425.158 µM 0.0791903530785329 0.467982553678354 no 1554 0.468440608811888 512 3100915
SGTC_1497 4476-2978 41.3 µM 0.0769126615447261 0.468993527800947 no 1555 0.469346512464707 512 1528379
SGTC_2539 epi(13)torulosol 80 µM 0.0767487678535688 0.469066281297243 no 1556 0.469411703892147 497 6708597
SGTC_2576 guaiol 23.12 µM 0.0760742708101393 0.469365705853827 no 1557 0.469680004864109 494 227829
SGTC_2782 7736369 71.43 µM 0.0759935507310344 0.469401540494363 no 1558 0.469712114566665 509 2950836 YOL077C BRX1
SGTC_728 3030-5151 22.5 µM 0.0758299081596264 0.469474188268692 no 1559 0.469777210675616 501 3125388
SGTC_912 3474-0017 2.18 µM 0.0747177803418321 0.469967935069274 no 1560 0.470219630275165 511 3360550
SGTC_2972 9093619 59.92 µM 0.0741174865247762 0.470234464278503 no 1561 0.470458450647753 456 25236256
SGTC_2054 5233173 129 µM 0.0738352725547942 0.470359771311367 no 1562 0.470570730086542 510 6889
SGTC_142 0335-0849 62.6745 µM 0.0733556125396319 0.470572753935018 no 1563 0.470761569224562 511 3889043 YPR107C YTH1
SGTC_1031 k035-0009 16 µM 0.0733256346429007 0.470586065249828 no 1564 0.47077349655423 518 5180959
SGTC_3028 9087778 49.47 µM 0.0713315520502016 0.471471586076067 no 1565 0.471566942137534 518 17217395
SGTC_1392 3455-1037 33.9 µM 0.070875583405523 0.471674090004517 no 1566 0.47174838805701 510 981132
SGTC_2867 9039098 71.43 µM 0.0706779457719849 0.471761866733078 no 1567 0.471827036828568 498 6463460
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.069023470267182 0.472496721714445 no 1568 0.472485468738885 517 6708514
SGTC_3143 9086658 49.47 µM 0.0689094330491354 0.47254737617933 no 1569 0.472530854941411 493 25236626
SGTC_2194 5927483 104.545 µM 0.0688288843516882 0.472583155565689 no 1570 0.472562913106913 490 760979
SGTC_1774 st048371 48.465 µM 0.0686167475555435 0.47267738687959 no 1571 0.472647343832587 524 4242727
SGTC_3015 9080845 49.47 µM 0.0674448720230329 0.473197962227833 no 1572 0.473113773889692 527 5296973
SGTC_703 3875-0075 71.8 µM 0.0670934033821518 0.47335410203106 no 1573 0.473253672701064 525 2850814
SGTC_3353 9151644 39.2805 µM 0.0667805743873541 0.473493079631266 no 1574 0.473378194137493 522 4909158
SGTC_330 1488-0319 80.1 µM 0.0659369610218897 0.473867879854551 no 1575 0.473714006979217 530 6846614
SGTC_920 mycophenolic acid 780.421 nM 0.0654891091936379 0.474066860714446 no 1576 0.473892288663276 516 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_2329 6138490 200 µM 0.0650283008720379 0.474271604905662 no 1577 0.474075733549888 498 720019
SGTC_2790 5423970 71.43 µM 0.0648762920210748 0.474339146258312 no 1578 0.474136248522439 502 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_3205 9113483 49.47 µM 0.0628624991252414 0.475233993913182 no 1579 0.47493799855918 520 17018033
SGTC_2195 6536160 144.242 µM 0.0625778295016471 0.475360499698682 no 1580 0.475051342151614 517 3834386
SGTC_2531 methyl deoxycholate 70.07 µM 0.0611314419639416 0.47600330533748 no 1581 0.475627264451465 521 16667744 Haematoxylin.
SGTC_2899 9053889 58.44 µM 0.061000276826673 0.476061601051034 no 1582 0.475679494295987 526 6470052
SGTC_820 1582-0060 59.9 µM 0.0605270032765634 0.47627194945189 no 1583 0.475867954883249 504 3848840
SGTC_1960 st011366 51.8 µM 0.0604682818147258 0.476298048912524 no 1584 0.475891338526307 525 3972846
SGTC_1042 0350-0096 82 µM 0.0598505873812212 0.476572596778659 no 1585 0.476137317427116 495 3122515
SGTC_2315 7733312 200 µM 0.0594555155307043 0.476748200984665 no 1586 0.476294648112319 506 726316
SGTC_1207 2099-0101 141 µM 0.058263787851185 0.477277935372657 no 1587 0.476769255800555 515 5837381
SGTC_1124 fisetin 1.16336 µM 0.0564383510604376 0.478089437077074 no 1588 0.477496302950265 500 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_315 k915-0449 187 µM 0.0553673534286689 0.478565593795509 no 1589 0.477922902057768 516 20970215 YNL149C PGA2
SGTC_69 0096-0274 206.684 µM 0.0551438524095405 0.478664964387375 no 1590 0.478011930050717 522 6741392
SGTC_3086 9117350 49.47 µM 0.0549986430132915 0.47872952652067 no 1591 0.478069772438382 522 2679265
SGTC_2738 aclarubicin 5.55 µM 0.0546150361649495 0.478900086183661 no 1592 0.478222579755352 516 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_447 ml7 120 µM 0.0542977283721756 0.479041170815156 no 1593 0.478348979690894 515 4216 Selective myosin light chain kinase inhibitor.
SGTC_2044 5102272 200 µM 0.0536255599057088 0.479340045875599 no 1594 0.478616745973917 517 592666
SGTC_802 4112-3352 742 µM 0.052864625131994 0.479678404270949 no 1595 0.478919885010146 491 704594
SGTC_2700 st077718 96.8 µM 0.0527627623333563 0.479723699852158 no 1596 0.478960465752169 513 904970
SGTC_2345 9052315 157.45 µM 0.0512548051826014 0.480394277182255 no 1597 0.479561240488222 515 6469265
SGTC_517 1365-0151 113 µM 0.051252539562828 0.48039528472874 no 1598 0.479562143153339 505 768657
SGTC_266 formosanin C 406 nM 0.0511386342988374 0.480445939836478 no 1599 0.479607525267104 530 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_2748 diazoxide 86.69 µM 0.0506210339025925 0.480676127227287 no 1600 0.479813750840386 531 3019 A potassium channel activatior.
SGTC_1641 st009299 47.1 µM 0.0493236357575705 0.481253134636404 no 1601 0.480330691914128 519 4046054
SGTC_280 3448-3607 3.04 µM 0.0471818317395409 0.482205770146564 no 1602 0.481184153782888 530 626179
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.0465124320841368 0.48250352804676 no 1603 0.481450912720521 520 6708739 YPR165W RHO1
SGTC_2674 ligustilide 100 µM 0.0459857082651691 0.482737828700099 no 1604 0.48166082050558 527 5319022 A signalling regulator.
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 0.0458006162275873 0.482820163942171 no 1605 0.481734583824615 525 279621
SGTC_2231 micatex 6.853 µM 0.0456139845638067 0.482903184804244 no 1606 0.481808961352281 514 20737 An antifungal of unknown mechanism.
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.0455514769855254 0.482930990718268 no 1607 0.481833872374772 526 2374 Ca(2+)-ATPase inhibitor.
SGTC_2164 5685496 200 µM 0.0453483347759557 0.483021357210833 no 1608 0.481914830730176 518 759046
SGTC_276 colchicine 750 µM 0.0445242937715838 0.483387935396479 no 1609 0.482243243773192 530 2833 A microtubule depolymerizer.
SGTC_282 k297-0036 65.7 µM 0.043947527607674 0.483644520678265 no 1610 0.482473115160654 529 5061378
SGTC_2007 4011539 71.82 µM 0.0437338780109226 0.483739568446787 no 1611 0.482558267147128 518 45595301
SGTC_1113 artemisinin 1.17947 µM 0.0431642866867161 0.483992970965515 no 1612 0.482785286818222 531 2240 An anti-malaria and mitochondrial poison.
SGTC_1374 2889-5571 141 µM 0.0431462073893965 0.484001014276376 no 1613 0.482792492701168 525 2853281
SGTC_516 3992-2719 87.3 µM 0.0430142028689258 0.484059742054225 no 1614 0.482845106040235 507 5350887 YDR037W KRS1
SGTC_3119 9125183 49.47 µM 0.042692783823853 0.48420274031491 no 1615 0.4829732160005 529 22695334
SGTC_386 1509-0011 3.07 µM 0.0417335080012553 0.48462953093624 no 1616 0.483355570849693 523 3107280
SGTC_1266 0828-0227 32.9 µM 0.040596995683203 0.485135198453062 no 1617 0.483808589640715 523 3913820
SGTC_2152 5568786 200 µM 0.0386386958597086 0.486006558850523 no 1618 0.48458922524036 529 5399883
SGTC_3243 9134147 49.47 µM 0.0372772272257917 0.486612394295419 no 1619 0.485131981455672 521 24282180
SGTC_1339 1486-1321 22.7 µM 0.0372266260165739 0.486634911765095 no 1620 0.48515215441554 510 3469382
SGTC_362 0310-0100 9.03 µM 0.0369613428588634 0.486752963107153 no 1621 0.485257914297207 524 790235
SGTC_1265 0819-1001 68.8 µM 0.0365414859862449 0.486939802316972 no 1622 0.485425299874961 525 3106768
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.0357929866573258 0.487272896775244 no 1623 0.485723712661064 527 616764
SGTC_1212 0520-0165 585 µM 0.0352985711685765 0.487492924647704 no 1624 0.485920831332304 535 5403258
SGTC_1728 st035614 33.7865 µM 0.0352700444186649 0.487505619917139 no 1625 0.485932204776892 510 15945546
SGTC_2460 5552655 174.22 µM 0.0344260285515269 0.487881238265419 no 1626 0.486268713993615 505 5401989
SGTC_536 3852-0578 10.6 µM 0.0341108149849103 0.488021522762381 no 1627 0.486394392196995 517 2869208
SGTC_3228 9131799 49.47 µM 0.0337374821261175 0.488187674926243 no 1628 0.48654324478018 511 17015818
SGTC_1698 5-fluorocytosine 1.055 µM 0.0329813766127734 0.488524186695092 no 1629 0.486844719435776 539 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_2499 avocadenofuran 51.48 µM 0.0328758777290588 0.488571140606362 no 1630 0.486886784589316 508 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_811 0416-0114 265 µM 0.0325453354550644 0.488718254584686 no 1631 0.48701858134821 537 6612453
SGTC_2979 9012552 45.46 µM 0.0320524453674221 0.488937627317715 no 1632 0.487215113502061 536 17100905
SGTC_475 α-linolenic acid 10 µM 0.0315650385800954 0.489154562865794 no 1633 0.487409462329793 506 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_418 lividomycin a 100 µM 0.0293318480901844 0.490148553790212 no 1634 0.488299963360578 533 72394 An antibiotic.
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.0284667021333143 0.490533646199598 no 1635 0.488644962554492 527 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_1884 5633444 25 µM 0.0281805021954584 0.490661041026375 no 1636 0.488759094021139 528 5724239
SGTC_3203 9113543 49.47 µM 0.0272536449334349 0.49107361509423 no 1637 0.48912871455243 527 17018012
SGTC_3247 9135149 49.47 µM 0.0265098937713276 0.491404689657548 no 1638 0.489425321142556 536 8934436 YOR116C RPO31
SGTC_3301 9125354 19.7965 µM 0.025131563698317 0.49201825716038 no 1639 0.489975011968791 531 41905162
SGTC_1142 3253-1408 9.78 µM 0.0247643426288809 0.492181729896668 no 1640 0.490121466395084 531 256655
SGTC_317 4495-0002 170 µM 0.0240586948321521 0.492495860894702 no 1641 0.490402895263078 534 15991618
SGTC_2589 lobaric acid 100 µM 0.0236718752281729 0.492668062141718 no 1642 0.490557170017042 530 73157 A novel microtubule depolymerizer.
SGTC_1086 cerivastatin 2.18 µM 0.023505307137438 0.492742214010363 no 1643 0.490623602586094 536 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_2075 5212009 200 µM 0.0232183691156317 0.492869952091127 no 1644 0.490738043060791 540 780898
SGTC_2477 5967686 25.23 µM 0.0230792192820703 0.492931898599078 no 1645 0.49079354094094 531 776118
SGTC_2594 a-mangostin 100 µM 0.022849389394246 0.493034214286065 no 1646 0.490885205626994 536 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_848 0368-0089 85.6 µM 0.02068851532621 0.493996213856469 no 1647 0.49174706525136 541 762535
SGTC_1846 st056244 14.8 µM 0.0204383341195545 0.494107594394785 no 1648 0.491846852012329 521 5393182
SGTC_2921 7974240 10.71 µM 0.0199576660738827 0.494321588831189 no 1649 0.492038571705844 538 2979074 YDR527W RBA50
SGTC_1821 st053465 65.6 µM 0.0197383964594684 0.494419208676401 no 1650 0.492126030397041 539 675086
SGTC_941 3237-0776 460 µM 0.0195625689030322 0.494497488158449 no 1651 0.492196161901624 539 760008
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 0.0186694111361332 0.494895130558453 no 1652 0.492552415188894 540 16725076
SGTC_2662 daunorubicin 22.37 µM 0.0176792084921833 0.495335984180206 no 1653 0.492947383638077 530 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2356 9061756 188.97 µM 0.0175354409563733 0.495399992210047 no 1654 0.493004729696771 531 20104043
SGTC_2111 5486399 200 µM 0.0174303552937279 0.495446778412347 no 1655 0.493046646404198 540 689674
SGTC_283 0987-0079 11.7 µM 0.0173019329464267 0.495503954650271 no 1656 0.493097871783317 540 411556
SGTC_1614 st002383 48.6 µM 0.0166741387446792 0.495783462689971 no 1657 0.49334828929265 540 1947235
SGTC_311 1315-0136 58 µM 0.0161186807679465 0.496030766752464 no 1658 0.49356985517657 539 6759207
SGTC_2794 7785382 27.27 µM 0.0160291254573449 0.496070639206826 no 1659 0.493605577961239 540 2205081
SGTC_2924 9010168 62.78 µM 0.0158461319963518 0.496152112982804 no 1660 0.493678572518574 538 2993929
SGTC_559 1550-0661 158 µM 0.014750050235357 0.496640122294842 no 1661 0.494115794689034 539 5830875
SGTC_1442 4112-3290 3 µM 0.0146205007733072 0.496697802046315 no 1662 0.494167471874231 539 704353
SGTC_767 0929-0023 86 µM 0.0140265816386003 0.496962235565643 no 1663 0.494404387020267 542 1204563
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.0136554306763438 0.497127485607728 no 1664 0.494552440648422 540 4330530
SGTC_586 0957-0265 8.15 µM 0.0135537458642536 0.497172759508527 no 1665 0.494593003265286 544 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_961 1252-1571 372 µM 0.0134552092356969 0.497216631754417 no 1666 0.494632310108193 539 6813498
SGTC_1022 4477-0945 21.3 µM 0.0133004639476259 0.497285530296034 no 1667 0.494694039022285 528 4648966
SGTC_616 4092-0450 108 µM 0.0123854217017445 0.497692943810774 no 1668 0.495059057945219 542 787165
SGTC_413 propylparaben 100 µM 0.0118355015220461 0.497937791519521 no 1669 0.495278428265608 536 7175 A pharmaceutical preservative.
SGTC_1982 st072467 71.9 µM 0.0109120832373487 0.498348938072524 no 1670 0.495646795021469 529 3163533
SGTC_2327 6189656 200 µM 0.0102878330761545 0.498626882800601 no 1671 0.495895820809723 543 5349088
SGTC_1048 3161-0300 24.5 µM 0.0101135956416187 0.498704461401711 no 1672 0.495965327872742 540 2165101
SGTC_2774 tamoxifen 10.92 µM 0.00898633092889959 0.499206373080269 no 1673 0.496415020897167 543 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.0083028385219117 0.499510696957546 no 1674 0.496687684723224 540 521171
SGTC_2618 avocadyne 43.43 µM 0.008302393644723 0.499510895038499 no 1675 0.496687862197427 542 3015189
SGTC_1222 0366-0074 1.18 µM 0.00764390239964327 0.499804087460756 no 1676 0.496950553841688 542 286520
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.00759943955745845 0.499823884492497 no 1677 0.496968291434146 537 4174840
SGTC_113 0099-0221 2.5 µM 0.00723528901674936 0.499986022133477 no 1678 0.497113562484199 546 89219
SGTC_2749 bexarotene 57.39 µM 0.00717250227033731 0.499986022133477 no 1679 0.497138610122041 543 82146 An retinoic acid receptor inhibitor.
SGTC_2827 7993847 71.43 µM 0.00675598391006757 0.499800567778294 no 1680 0.497304772875763 544 2985692
SGTC_2687 chenodiol 100 µM 0.00663138190732506 0.49974508887617 no 1681 0.497354480769244 546 5702181 A cholesterol synthesis inhibitor.
SGTC_261 5-fluorouridine 15.376 µM 0.00516952959069846 0.499094201424821 no 1682 0.49793766526214 544 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_727 3032-0951 202 µM 0.00491508833750524 0.498980912053497 no 1683 0.498039171345245 546 3652836
SGTC_2206 7254556 146.969 µM 0.00491399718071699 0.498980426218667 no 1684 0.498039606648565 546 4398905
SGTC_68 0986-0284 82.829 µM 0.00472224784548151 0.498895050330886 no 1685 0.498116102677606 546 423278 YIL048W NEO1
SGTC_3325 9138760 55.175 µM 0.00463478418241258 0.498856107381245 no 1686 0.498150995248917 543 43844959
SGTC_1196 1588-0294 184 µM 0.00437280494986609 0.498739461932513 no 1687 0.498255508781077 546 6144269
SGTC_1930 st074634 34.3 µM 0.00401300362028064 0.498579261673152 no 1688 0.498399047481477 543 684253 YOR116C RPO31
SGTC_3215 9129942 49.47 µM 0.00388423098921968 0.498521926172553 no 1689 0.49845041992804 547 17682944
SGTC_661 1304-0007 33.6 µM 0.00377486241165005 0.498473230273342 no 1690 0.49849405135782 544 3117130
SGTC_3197 9113331 49.47 µM 0.00292539725841709 0.498095010316519 no 1691 0.498832937011258 542 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_895 0964-0006 13.7 µM 0.00284523985324624 0.498059320730421 no 1692 0.49886491505615 542 6738897
SGTC_2349 9023730 187.07 µM 0.00253242826737539 0.497920043468621 no 1693 0.498989708371926 545 4126287
SGTC_2828 7998861 71.43 µM 0.00158451549977914 0.497497993281047 no 1694 0.4993678700377 546 2988188
SGTC_2658 polymyxin b sulfate 77.05 µM 0.000946580507656341 0.497213959638458 no 1695 0.499622369070086 548 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_1223 0764-0573 147 µM 0.000769854103052123 0.497135274365487 no 1696 0.49969287267889 547 1609797
SGTC_975 1335-0046 28.5 µM 0.000434180909714447 0.496985820285737 no 1697 0.499826786883214 546 16486740
SGTC_736 0958-0254 92.6 µM 0.000198515563150184 0.49688089363752 no 1698 0.499920803749062 547 6812352
SGTC_2641 levomentholum 100 µM 0.000194614195952803 0.496879156610985 no 1699 0.499922360169358 547 16666
SGTC_363 0455-0021 3.06 µM 4.93959551574293e-05 0.496814500361128 no 1700 0.499980293865015 548 4597466
SGTC_1755 st041960 45.185 µM -0.00013622863605003 0.496731853910127 no 1701 0.499945652637446 548 2257073
SGTC_1503 4585-0012 61.3 µM -0.000361254863765249 0.496631664684086 no 1702 0.499855880163978 551 2922052
SGTC_874 0599-0792 117 µM -0.00063442661297062 0.496510039742732 no 1703 0.499746900417253 549 765305
SGTC_2714 st079313 56.9 µM -0.000711423095796938 0.496475758464157 no 1704 0.499716183271774 548 2939799
SGTC_2814 7977482 42.97 µM -0.000950550179763674 0.496369291661818 no 1705 0.499620785400755 550 6456762
SGTC_1558 st069300 45.6 µM -0.00196862061243781 0.495916018081808 no 1706 0.499214634510905 551 24208000
SGTC_1041 0206-0046 107 µM -0.00219367745372119 0.495815817139611 no 1707 0.49912485001605 552 50494
SGTC_620 0109-0052 432 µM -0.0023082402503268 0.495764811014374 no 1708 0.499079146188534 549 493037
SGTC_599 1935-0052 86.5 µM -0.00325931237791409 0.495341373473922 no 1709 0.498699724789577 552 9557311
SGTC_1327 1436-0082 2.18 µM -0.00357006764932093 0.4952030197318 no 1710 0.498575752096224 552 15992205
SGTC_1135 dihydrocapsaicin 536.708 nM -0.00376595926377955 0.495115805616408 no 1711 0.498497603174687 553 107982 A Capsaicinoid.
SGTC_2340 7987427 183.45 µM -0.00503262965071493 0.49455186928964 no 1712 0.497992279725774 551 2239331
SGTC_105 0111-0055 734.78 µM -0.00579133108645014 0.49421409176485 no 1713 0.497689606084735 559 5179370
SGTC_1401 3807-4679 7.6 µM -0.00621545144704469 0.494025273134495 no 1714 0.49752040959119 550 3291456
SGTC_667 1498-1044 59 µM -0.00716062945498646 0.493604484215478 no 1715 0.497143346568439 555 6739982
SGTC_715 0868-0130 184 µM -0.00731849304164686 0.49353420475078 no 1716 0.497080369759618 552 2876258
SGTC_2956 9076196 2.52 µM -0.00748028473194393 0.493462176737545 no 1717 0.497015825980753 553 16423868
SGTC_684 1140-0066 328 µM -0.00816258778332503 0.493158424738522 no 1718 0.496743634776547 555 6813534
SGTC_2276 7947513 42.08 µM -0.00819378893224783 0.493144534506702 no 1719 0.496731187735298 567 2105100
SGTC_1781 st038725 66.3 µM -0.00840435533737827 0.49305079406848 no 1720 0.49664718678643 554 4270275 YIL048W NEO1
SGTC_832 4083-0019 164 µM -0.00857771178347717 0.492973619133497 no 1721 0.496578030063651 553 1990758
SGTC_2126 5251174 33.877 µM -0.00868307819163374 0.492926712175972 no 1722 0.49653599651396 552 790722
SGTC_3326 9140064 16.379 µM -0.00949346956721579 0.492565945922586 no 1723 0.496212710490872 556 1868434
SGTC_3152 9099253 49.47 µM -0.00981414849468806 0.492423189235861 no 1724 0.496084784070074 556 25236131
SGTC_2425 5628681 7.85 µM -0.00985122604820074 0.492406683477987 no 1725 0.496069992981356 553 5714958
SGTC_2381 9035592 200 µM -0.010315709594309 0.492199911157912 no 1726 0.495884700278108 560 4749657
SGTC_2260 7964312 200 µM -0.0106814406615885 0.492037101563956 no 1727 0.495738802733568 561 231951
SGTC_3003 9075612 71.4286 µM -0.0108017167622637 0.491983559496194 no 1728 0.495690822279824 556 6501993
SGTC_1433 4060-0023 7.6 µM -0.0110072595812935 0.491892060460152 no 1729 0.495608827434086 553 3840627
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.011018858947256 0.491886896921942 no 1730 0.495604200237196 554 6710655
SGTC_3266 9136860 49.47 µM -0.0111599660898587 0.491824082207845 no 1731 0.495547910093241 553 4871271 YPR165W RHO1
SGTC_2628 lathosterol 100 µM -0.0112899927491363 0.49176620021864 no 1732 0.495496040229221 556 6710616
SGTC_3052 9092717 49.47 µM -0.0128416116728124 0.491075503355788 no 1733 0.494877078956521 557 25237534
SGTC_2214 7179297 48.276 µM -0.0138919501191139 0.490607964523078 no 1734 0.494458091992864 553 769744
SGTC_169 k015-0017 16.025 µM -0.0156504926856823 0.489825210868807 no 1735 0.49375661163337 558 1840002
SGTC_482 fipronil 114 µM -0.0156672982484657 0.48981773064515 no 1736 0.493749908005748 553 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_1617 st002906 78 µM -0.01590848941295 0.489710375882582 no 1737 0.493653698644013 565 5150859
SGTC_230 MPP+ 141.667 µM -0.016006012006055 0.489666968554995 no 1738 0.493614797711407 565 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_1300 1094-0077 113 µM -0.0162761257728857 0.489546741498626 no 1739 0.493507051946265 552 5532636
SGTC_847 0342-0274 5.54 µM -0.0171799272819594 0.489144468359736 no 1740 0.49314653776778 566 18097
SGTC_2408 sulbentine 18.36 µM -0.0173768570751322 0.489056818301846 no 1741 0.493067985873567 564 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_1258 0671-0043 57.1 µM -0.0177464085304626 0.488892338746124 no 1742 0.492920578906804 559 4298767
SGTC_2906 7926292 26.41 µM -0.0179026579432544 0.488822795995734 no 1743 0.492858254311301 555 2966319
SGTC_1875 nocodazole 6 µM -0.0180305498419044 0.488765874726561 no 1744 0.492807241059818 554 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_2354 9060492 162 µM -0.0181167727395216 0.488727499346184 no 1745 0.492772848718143 552 6471895
SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.0188440691554086 0.488403804407917 no 1746 0.49248274897638 585 61125 An anti-inflammatory.
SGTC_3338 9144300 39.5675 µM -0.0190569062164617 0.488309079294468 no 1747 0.492397854519109 566 4901274
SGTC_2793 7325131 81.82 µM -0.0194033337518065 0.488154899910701 no 1748 0.49225967548035 561 4176441
SGTC_1359 1582-0056 520 nM -0.0200669552345189 0.487859556667234 no 1749 0.491994980368776 566 3661189
SGTC_1644 st010134 20.9 µM -0.0215325373759736 0.487207326460736 no 1750 0.491410424201236 556 3818134
SGTC_1185 1319-0113 81.3 µM -0.0216718463544554 0.487145331331587 no 1751 0.491354860925669 556 4672763
SGTC_304 1310-0298 97 µM -0.0220864473133001 0.4869608279104 no 1752 0.491189498658828 560 1550234
SGTC_1727 st034309 9.9045 µM -0.0222832163224862 0.486873263830501 no 1753 0.491111018496758 584 870305
SGTC_2010 4012422 159 µM -0.0230950002948997 0.486512018982144 no 1754 0.490787246905325 566 952393
SGTC_623 k072-0108 16.9 µM -0.0233168333154132 0.486413304932968 no 1755 0.490698772160112 568 5382803
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.0234740638624737 0.486343339009218 no 1756 0.490636063411255 555 688669
SGTC_2199 6590217 200 µM -0.0237969300853529 0.486199668288944 no 1757 0.490507294397168 557 703109
SGTC_2799 7812892 81.82 µM -0.0239264091049394 0.486142052531838 no 1758 0.490455654445318 556 20205235
SGTC_2655 perillic acid 100 µM -0.0249159963206441 0.485701714256159 no 1759 0.490060983988248 564 5702197 An apoptosis inducer.
SGTC_656 4090-1979 187 µM -0.0253240319985802 0.485520154984891 no 1760 0.489898252656601 560 22330961
SGTC_1831 st055328 12 µM -0.0253297157204962 0.485517625981053 no 1761 0.489895985906739 557 1103068
SGTC_1669 st015249 58.4 µM -0.0257279857502608 0.485340414961289 no 1762 0.489737150920478 562 722793
SGTC_197 4544-0043 41.561 µM -0.0267056324240881 0.48490542153144 no 1763 0.489347260355544 559 896523
SGTC_629 3448-6466 76.7 µM -0.0267251128089603 0.484896754123375 no 1764 0.489339491579206 561 573744
SGTC_2649 anisomycin 9.56 µM -0.0274387604516466 0.484579235814732 no 1765 0.489054891753614 572 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_1340 1486-1359 257 µM -0.0274901957847288 0.48455635142317 no 1766 0.489034379762075 569 4309068
SGTC_922 1866-0035 480 µM -0.0276902162553908 0.484467359642796 no 1767 0.488954613505108 571 3156169
SGTC_49 0717-0965 32.132 µM -0.0277608396632327 0.484435938529454 no 1768 0.488926449668659 573 5889349 YGL099W LSG1
SGTC_2427 5545055 42.75 µM -0.0285539604554744 0.484083077245836 no 1769 0.488610165665485 567 5372858
SGTC_3196 9111891 49.47 µM -0.0290286303547947 0.483871901449294 no 1770 0.488420878245282 558 18891510
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.0292047843383359 0.483793533486597 no 1771 0.488350632756242 567 4213774
SGTC_1709 st033179 39.1045 µM -0.029582466574868 0.483625511086916 no 1772 0.488200024420171 566 573381
SGTC_514 4466-0038 2.65 nM -0.0318304354152351 0.482625501087117 no 1773 0.487303637488409 573 5722064
SGTC_3207 9114163 49.47 µM -0.0318839565484452 0.482601693492899 no 1774 0.48728229647752 579 849233
SGTC_3135 9127742 49.47 µM -0.034392410451628 0.48148593890175 no 1775 0.486282117737723 561 3643468
SGTC_2970 9090938 41.86 µM -0.0347880021142248 0.481309993643451 no 1776 0.486124393883901 577 17217104
SGTC_581 0958-0271 211 µM -0.0349355557322896 0.481244367914073 no 1777 0.486065564267046 572 4591145
SGTC_2166 5933061 31.504 µM -0.0360663755781003 0.480741443153521 no 1778 0.485614716638394 567 2877375
SGTC_1369 1866-0067 208 µM -0.0377289982278889 0.480002058451503 no 1779 0.484951877604497 572 3531355
SGTC_771 0250-0039 27.3 µM -0.0386911718273103 0.479574201621178 no 1780 0.484568306000919 588 3005115
SGTC_2092 5303694 80.6725 µM -0.0395323750838981 0.479200156830001 no 1781 0.484232971049553 574 1963699
SGTC_480 am 92016 50 µM -0.0405547290921019 0.47874558723696 no 1782 0.483825437695918 577 2129 K+ channel blocker.
SGTC_1711 st032263 62.8 µM -0.0406249157510153 0.478714381127517 no 1783 0.483797460326488 567 3958979
SGTC_647 0140-0236 81 µM -0.0408536518109132 0.478612682328912 no 1784 0.483706283535313 574 990837
SGTC_3049 9092223 49.47 µM -0.04133608219528 0.478398192561255 no 1785 0.483513984104571 583 8623917
SGTC_154 3389-1638 511.116 µM -0.0423086218601324 0.477965818051908 no 1786 0.483126336095782 612 5238686
SGTC_1759 st043059 70 µM -0.0426849515361936 0.477798515242502 no 1787 0.482976337785428 577 669426
SGTC_327 1273-0057 3.96 µM -0.0435834290921751 0.477399099904951 no 1788 0.482618230407234 571 3108138
SGTC_495 decylubiquinone 155 µM -0.0440105207991787 0.477209245582025 no 1789 0.482448008804721 584 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_1914 st062367 72.6 µM -0.0443752184669999 0.477047131263929 no 1790 0.482302657491855 582 978205
SGTC_199 4063-0024 41.6 µM -0.0443763482631457 0.477046629056209 no 1791 0.48230220721197 561 306215
SGTC_2627 acetyl isogambogic acid 100 µM -0.0448075577114765 0.476854954036916 no 1792 0.482130350481213 581 6857789 A caspase activator and apoptosis inducer.
SGTC_2344 7990960 76.95 µM -0.0461398829738042 0.476262762008275 no 1793 0.481599378913191 579 140813
SGTC_3182 9108849 49.47 µM -0.0464233599796923 0.476136768847701 no 1794 0.481486409005333 559 17133045
SGTC_1579 chlormadinone acetate 49.4 µM -0.0472040054301629 0.475789818375095 no 1795 0.481175317605509 587 45114258 A steroidal progestin.
SGTC_827 3253-0474 693 µM -0.0472903932033744 0.475751425271169 no 1796 0.481140892315477 574 5402065
SGTC_1600 coumarin 106 71.1 µM -0.0477325763980676 0.475554910423027 no 1797 0.480964685736326 569 100336 A hepatotoxic, DNA x-linker.
SGTC_2062 5245942 200 µM -0.0479029956135696 0.47547917437999 no 1798 0.480896775989548 569 1376160
SGTC_1151 3909-8316 15.3 µM -0.0479402093618058 0.475462636327275 no 1799 0.480881946889111 571 800431
SGTC_2438 5259590 200 µM -0.0480767494316559 0.475401957317589 no 1800 0.480827538019629 570 1201127
SGTC_685 1278-0033 54.9 µM -0.0489346786153987 0.475020702912397 no 1801 0.480485676208731 571 3590572
SGTC_2895 9054447 58.44 µM -0.0510048862594582 0.474100819992858 no 1802 0.479660813473084 568 2697450
SGTC_596 1155-0152 116 µM -0.0514147199565683 0.473918729347624 no 1803 0.4794975277288 565 280313
SGTC_2764 methyldopa 94.69 µM -0.0529237229406252 0.473248320934363 no 1804 0.478896341353801 579 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_869 0564-0080 44.1 µM -0.0534658818014925 0.473007473104835 no 1805 0.478680357064395 573 6843321
SGTC_1568 digitonin 820 nM -0.0542123825867413 0.472675864894436 no 1806 0.47838297765791 575 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_72 0744-0168 198.391 µM -0.0542452546333546 0.47266126301181 no 1807 0.478369882877171 589 677577
SGTC_1604 st002052 72.4 µM -0.0554915483283542 0.472107682100524 no 1808 0.477873431516948 569 6254834 YHR062C RPP1
SGTC_972 1319-0219 195 µM -0.0562300781163317 0.471779666003125 no 1809 0.477579260094827 567 23903702
SGTC_577 r071-0003 38.6 µM -0.0572127917640315 0.471343225992974 no 1810 0.477187844248925 567 4568517 YMR134W ERG29
SGTC_405 ebelactone b 50 µM -0.0584981734986399 0.470772417910797 no 1811 0.476675908671032 564 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_3164 9100705 49.47 µM -0.0590411069728888 0.470531331773427 no 1812 0.476459683285224 571 17174235
SGTC_1896 st058441 89 µM -0.060122383165847 0.470051230254878 no 1813 0.47602908150951 574 688759
SGTC_866 0495-0101 262 µM -0.060141931724585 0.470042550824162 no 1814 0.476021296849823 592 635694
SGTC_1695 st026914 34.495 µM -0.0605615475434502 0.469856247615967 no 1815 0.4758541989497 582 3289191
SGTC_159 3970-0959 50 µM -0.0609439891694575 0.469686454945447 no 1816 0.475701908120738 581 6615653
SGTC_2149 5554786 194.827 µM -0.0610292977296698 0.469648581240995 no 1817 0.475667938161412 580 745063 YPR165W RHO1
SGTC_195 4234-0266 16.654 µM -0.0613308038585422 0.469514726372502 no 1818 0.475547879519309 583 2303354
SGTC_1314 1222-0010 41.1 µM -0.0615924363848479 0.469398576342952 no 1819 0.47544370019917 579 3526027
SGTC_357 1325-0123 420 µM -0.061960794891283 0.469235050436872 no 1820 0.475297026563616 604 1098503
SGTC_1615 st002656 86.5 µM -0.0637862239620859 0.468424762274022 no 1821 0.474570223802818 572 1584458
SGTC_183 3914-0051 30.55 µM -0.0640996463067143 0.468285650557722 no 1822 0.474445441737515 574 1596232
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.0641801230979095 0.468249931761283 no 1823 0.474413402115052 574 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_538 2922-0838 53.3 µM -0.0646317620575279 0.468049481202441 no 1824 0.474233597553051 589 777039
SGTC_1502 4534-4282 27.7 µM -0.0649862335477368 0.467892162075284 no 1825 0.474092480560791 574 3278949
SGTC_1893 st059353 36.1 µM -0.0656689471681022 0.467589178907853 no 1826 0.473820697799521 612 3112488
SGTC_406 estrone 100 µM -0.0658082512698759 0.467527359096419 no 1827 0.473765243457814 580 5870 A steroid.
SGTC_328 k915-0120 63.5 µM -0.0667532646889526 0.467108005613019 no 1828 0.473389064873925 579 6624543
SGTC_422 cantharidin 155 µM -0.0682722145238476 0.466434042242376 no 1829 0.472784471052473 571 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2968 9090663 33.37 µM -0.0684221832624537 0.466367505775497 no 1830 0.47272478175938 605 25236811
SGTC_553 k007-0256 45.7 µM -0.0687437435120542 0.46622484266075 no 1831 0.472596799125903 577 6287000
SGTC_1024 4507-0395 26 µM -0.0704735333455108 0.465457480667908 no 1832 0.471908382746141 573 4201836
SGTC_1395 3486-0190 4.35 µM -0.0723023069243805 0.464646347641429 no 1833 0.471180664421756 596 6748079
SGTC_3317 9138495 8.753 µM -0.0731452980385045 0.464272497177981 no 1834 0.470845247775644 576 17020139
SGTC_1710 st031758 61.5 µM -0.0751543704252684 0.463381639704238 no 1835 0.470045944377528 569 5394341
SGTC_2517 totarol 10 µM -0.0754045714085761 0.463270709021951 no 1836 0.469946411054496 586 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_2679 rapamycin 1 nM -0.0765534521234552 0.462761370836281 no 1837 0.469489395026266 586 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_2086 5274770 176.623 µM -0.0786205513336921 0.461845109216883 no 1838 0.468667220267674 584 689278
SGTC_2902 5787006 60.46 µM -0.0793814446050823 0.461507886672534 no 1839 0.468364613561133 591 591003
SGTC_2252 omeprazole 400 µM -0.0797484783664758 0.461345229770795 no 1840 0.468218651022163 601 4594 A proton pump inhibitor.
SGTC_1416 3966-0321 25.3 µM -0.0818619038576845 0.460408757990707 no 1841 0.467378264519621 591 582530 YLR208W SEC13
SGTC_2704 st078022 71.1 µM -0.0831983633971523 0.459816677570663 no 1842 0.466846907024767 602 54697681
SGTC_704 1310-0270 142 µM -0.0836214633881314 0.459629253649616 no 1843 0.46667870069336 593 5718033
SGTC_368 fentichlor 4.58 µM -0.0836224886220153 0.459628799504601 no 1844 0.466678293111745 584 7329 A pesticide.
SGTC_3055 9094636 49.47 µM -0.0836464830947657 0.45961817075449 no 1845 0.466668754121792 591 25236176
SGTC_1244 0416-0015 52.5 µM -0.0837969954325487 0.459551499473971 no 1846 0.466608918458429 596 96201
SGTC_1183 1254-0324 198 µM -0.0844842725873423 0.459247076137641 no 1847 0.466335703395152 593 5799357
SGTC_3302 9125395 16.351 µM -0.0855299023130695 0.45878396958907 no 1848 0.465920061978075 598 17599668
SGTC_2431 5490079 200 µM -0.0862762966145759 0.458453427768215 no 1849 0.465623390382751 605 5722345
SGTC_1860 st056228 74.6 µM -0.0866009583831495 0.458309659775424 no 1850 0.465494352042351 583 688679
SGTC_540 1187-0821 17.3 µM -0.0867390856296432 0.45824849538113 no 1851 0.465439453820671 578 847520
SGTC_1247 0448-0043 5.84 µM -0.0885482640939626 0.45744746136158 no 1852 0.464720462879313 611 3089013 YGL099W LSG1
SGTC_910 3454-3003 490 µM -0.0892892136784242 0.457119447340312 no 1853 0.464426033033883 587 820824
SGTC_319 1348-1596 45.5 µM -0.089621859606904 0.45697219643261 no 1854 0.46429385642662 594 5380505
SGTC_3341 9147222 25.867 µM -0.0898084537965276 0.456889600189743 no 1855 0.464219715091142 605 1939759
SGTC_782 0083-0095 30.5 µM -0.0900835864811035 0.456767815626538 no 1856 0.464110396137328 630 3591729 An indicator and reagent.
SGTC_2600 tangeritin 87.95 µM -0.0910438840714946 0.456342781980829 no 1857 0.463728860690782 605 68077 A bioactive flavone.
SGTC_184 1494-0393 24.714 µM -0.0913288959475786 0.456216643553997 no 1858 0.463615629141092 593 3090647
SGTC_1993 st073995 70.8 µM -0.0914131100514492 0.456179373548973 no 1859 0.463582172525317 587 3098394
SGTC_114 0364-0001 490.298 µM -0.0914211742736492 0.456175804646793 no 1860 0.463578968781126 594 4003655
SGTC_588 3970-1144 52.9 µM -0.091598095058828 0.456097507474208 no 1861 0.463508682505784 583 1888707
SGTC_1732 st034308 51.822 µM -0.0921026207313226 0.455874236503773 no 1862 0.463308253131314 575 830119
SGTC_2495 cafestol 54.53 µM -0.0923142217757333 0.455780599484557 no 1863 0.463224194638106 631 16667697 An anti-infammatory.
SGTC_2537 larixol 68.93 µM -0.0926000612771317 0.455654114600944 no 1864 0.463110647533284 584 6708759
SGTC_387 norethindrone acetate 66.7 µM -0.0926423481719888 0.455635402897534 no 1865 0.463093849709409 610 541197
SGTC_1279 0874-0590 65.2 µM -0.0929416904094019 0.455502948526287 no 1866 0.46297494245563 597 3523074
SGTC_2127 5253358 187.912 µM -0.0947085657534839 0.454721234393338 no 1867 0.46227315703848 598 20612
SGTC_2402 5553605 200 µM -0.0948138900811063 0.454674641527915 no 1868 0.462231326943955 607 6758546
SGTC_908 3448-7491 47.7 µM -0.0953105775530401 0.454454927747128 no 1869 0.462034070615694 595 1203031
SGTC_659 k018-0002 107 µM -0.0967892622895641 0.453800902169159 no 1870 0.461446875673946 604 6797879 YHR007C ERG11
SGTC_1206 3978-0017 132 µM -0.0967974124017413 0.453797297701743 no 1871 0.461443639445206 628 3873677
SGTC_831 k061-1017 217 µM -0.0976307063727731 0.453428785370848 no 1872 0.461112770408436 606 1240153
SGTC_2331 7980721 200 µM -0.0980138715903657 0.453259349476809 no 1873 0.460960639234621 600 2981221
SGTC_1080 nisoldipine 24.4 µM -0.098074693722509 0.453232454674415 no 1874 0.460936491058261 598 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_1111 tnp00062 510.699 nM -0.0983646777134414 0.453104230254484 no 1875 0.460821360862185 589 676306
SGTC_196 k015-0023 18.111 µM -0.0988502729077963 0.452889521901401 no 1876 0.460628575957604 592 5211998
SGTC_1033 k072-0102 21.3 µM -0.0996720949876119 0.45252618055438 no 1877 0.46030232758471 585 5965931
SGTC_36 0335-0881 14.2 µM -0.100355726393203 0.452223965898746 no 1878 0.460030958739476 591 23828853
SGTC_925 2064-1272 59.6 µM -0.100557008839989 0.452134989727805 no 1879 0.459951062814191 624 6815817
SGTC_198 3454-2873 16.191 µM -0.100716085922697 0.45206467198447 no 1880 0.45988792079324 610 710957
SGTC_3229 9132204 49.47 µM -0.100755402289931 0.452047292979769 no 1881 0.459872315213548 589 17682924
SGTC_2978 9011784 42.97 µM -0.101786100205888 0.451591726695967 no 1882 0.45946322938633 596 2994934
SGTC_194 1486-1323 56.904 µM -0.103332856347701 0.450908183565085 no 1883 0.458849399795626 585 5178754
SGTC_2061 5245884 80.95 µM -0.103731464850882 0.450732053834599 no 1884 0.458691228001604 609 573863
SGTC_3094 9117742 49.47 µM -0.104730248947132 0.450290772330905 no 1885 0.458294929378688 596 17149698
SGTC_443 clozapine 122 µM -0.105366731378035 0.450009594504402 no 1886 0.458042406798196 586 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_2175 5807670 165.306 µM -0.105893883329709 0.449776734420983 no 1887 0.457833273588739 592 241186
SGTC_1605 st000082 49.1 µM -0.106454834948962 0.449528962923033 no 1888 0.457610744101848 625 1114022
SGTC_3105 9121040 49.47 µM -0.106852120184663 0.449353494520865 no 1889 0.457453149097488 599 41448907
SGTC_1177 0983-0204 23.6 µM -0.107231279488397 0.449186041008813 no 1890 0.457302750521792 593 766818
SGTC_458 nppb 133 µM -0.10886598577638 0.448464186431187 no 1891 0.456654392834866 598 4549 A chloride channel blocker.
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.1093855743619 0.448234781808372 no 1892 0.456448337539995 594 2724278 An inhibitor of dopamine biosynthesis.
SGTC_1100 amiodarone 5.07 µM -0.109921212466741 0.447998309250167 no 1893 0.456235929683646 598 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_2097 5376186 200 µM -0.110102450272111 0.447918300885922 no 1894 0.456164062469044 603 742755
SGTC_1163 k060-0048 49.9 µM -0.110653205524883 0.447675180153882 no 1895 0.455945677297656 588 6809982
SGTC_1180 1193-0155 285 µM -0.111638506735116 0.447240286233736 no 1896 0.455555019445766 609 2921347
SGTC_1721 st082152 9.2685 µM -0.112180455556191 0.447001106948641 no 1897 0.455340162774693 605 5296051
SGTC_3155 9099265 49.47 µM -0.112941050535139 0.446665464674422 no 1898 0.455038645450216 611 25236499
SGTC_2443 5493264 126.67 µM -0.113336156160735 0.446491123930341 no 1899 0.454882026713352 623 5340055
SGTC_102 gallobenzophenone 83.616 µM -0.115958081666952 0.445334460353327 no 1900 0.453842881799161 597 70837
SGTC_2614 arthonioic acid 13.39 µM -0.116612515572344 0.445045828714344 no 1901 0.453583559701536 618 6710684
SGTC_2715 st079500 56.4 µM -0.116948921492524 0.444897471517509 no 1902 0.45345026518093 601 28246688
SGTC_3218 9131285 49.47 µM -0.117380679814316 0.444707074604214 no 1903 0.45327919675035 618 17156417
SGTC_852 0418-0143 439 µM -0.119911188384067 0.443591428075478 no 1904 0.452276750690464 597 5369229
SGTC_2961 9083290 32.55 µM -0.120236364187858 0.443448097314042 no 1905 0.452147956130381 614 17741490
SGTC_3279 9140807 49.47 µM -0.12040535533498 0.443373612435768 no 1906 0.452081024661685 589 45595718
SGTC_93 0109-0045 59.227 µM -0.120534201385023 0.443316823335447 no 1907 0.452029994173405 592 88733
SGTC_756 0508-1999 28.3 µM -0.120596710765361 0.443289272646558 no 1908 0.452005237128703 608 6753853
SGTC_780 0109-0199 192 µM -0.122944495800422 0.442254698107704 no 1909 0.451075525161942 599 610414
SGTC_1362 1611-0397 101 µM -0.124388175377861 0.441618721552843 no 1910 0.450503967659111 593 27816
SGTC_563 tetrahydrosecaminediol 614 µM -0.128157502248321 0.439958953283781 no 1911 0.449012165479051 610 334274 A psychoactive constituent of the cannabis plant.
SGTC_2268 7933382 153.85 µM -0.129639490968634 0.439306668321982 no 1912 0.448425828801133 595 935025 YOR257W CDC31
SGTC_2904 7225135 42.03 µM -0.129657974179109 0.439298534127803 no 1913 0.448418516779096 613 4446116
SGTC_3060 1327-0027 12.5 µM -0.130520910530959 0.438918796882876 no 1914 0.448077155720172 595 16000455 YPR107C YTH1
SGTC_3 0833-0587 95.581 µM -0.131349399056604 0.438554271374228 no 1915 0.44774945773132 599 5382644
SGTC_99 0109-0120 622.8 µM -0.13141406021168 0.438525823391588 no 1916 0.447723883339708 641 759414
SGTC_247 mechlorethamine 29.705 µM -0.13205921846732 0.4382420003668 no 1917 0.447468726140434 604 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_438 sphingosine 6.67 µM -0.132158767150375 0.438198208962862 no 1918 0.447429357015623 607 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_137 0438-0332 85.389 µM -0.132516472459865 0.438040860867852 no 1919 0.447287897392372 626 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_2830 7992007 71.43 µM -0.133573401390796 0.437575994273914 no 1920 0.446869959143985 589 1952075
SGTC_7 0192-1582 4.227 µM -0.134861558896877 0.437009543497535 no 1921 0.446360666688934 604 252616
SGTC_2391 6285546 200 µM -0.135187563394645 0.436866207618985 no 1922 0.446231789899858 591 846083
SGTC_3066 9117245 49.47 µM -0.135238891236574 0.436843640828226 no 1923 0.446211499385763 620 17176980
SGTC_1274 0865-0114 173 µM -0.135590780401305 0.436688934832441 no 1924 0.446072397156387 597 870624
SGTC_2342 7990637 118.86 µM -0.135767149401166 0.436611398883149 no 1925 0.446002680764688 640 2033102 YER133W GLC7
SGTC_2948 9070189 9.45 µM -0.136080535768039 0.436473632895376 no 1926 0.445878807294177 606 6473636 YDL196W YDL196W
SGTC_1820 st053765 18.6 µM -0.136107557548421 0.43646175436571 no 1927 0.445868126535228 612 3690829
SGTC_1192 1488-0095 21.4 µM -0.136421809813 0.436323616129979 no 1928 0.445743916559706 623 915875
SGTC_2328 6201408 200 µM -0.136949077816819 0.436091858415599 no 1929 0.445535522883363 636 2890418
SGTC_2360 9040895 200 µM -0.138082535137407 0.435593727943437 no 1930 0.44508759424416 626 4914414
SGTC_787 4152-0075 138 µM -0.138513771797888 0.435404235357746 no 1931 0.44491719310404 592 9566539
SGTC_2974 9094440 9.66 µM -0.138691713361203 0.435326049185293 no 1932 0.444846883296016 614 25236134
SGTC_2984 9022109 38.96 µM -0.138867515589307 0.435248805503369 no 1933 0.444777420504587 615 6459207
SGTC_2385 9074692 200 µM -0.139694654972804 0.434885411624906 no 1934 0.444450624855106 597 17046906
SGTC_1063 disulfiram 1.84 µM -0.141007135573055 0.434308901827293 no 1935 0.443932152648316 591 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1673 st016611 27.3 µM -0.141736169225948 0.433988732560757 no 1936 0.443644202212613 632 5226799
SGTC_3272 9137413 49.47 µM -0.142044765975388 0.433853219345603 no 1937 0.443522323009337 652 17614870
SGTC_200 k038-0079 37.545 µM -0.14239641896776 0.433698808442423 no 1938 0.443383445407134 607 3436683
SGTC_2543 pimpinellin 60.67 µM -0.143423471157392 0.433247887623627 no 1939 0.442977873647486 617 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_800 3448-7362 155 µM -0.143779065875352 0.433091786213397 no 1940 0.442837467054494 613 15991913
SGTC_1912 st060209 90.8 µM -0.144451818448547 0.432796485247419 no 1941 0.442571850317214 627 688787
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.144935538618461 0.432584182175846 no 1942 0.442380883457216 614 688788
SGTC_2273 7815444 169.05 µM -0.144963721885639 0.432571813238945 no 1943 0.442369757457251 649 2824616
SGTC_893 0958-0369 48.9 µM -0.145750970297002 0.432226336181732 no 1944 0.442058991243722 630 6819948
SGTC_2991 9074669 71.4286 µM -0.145927406402415 0.432148915843403 no 1945 0.441989347997166 618 17333109
SGTC_134 0269-0018 6.916 µM -0.146532547631869 0.431883399081559 no 1946 0.441750498958096 599 4378915
SGTC_3154 9100113 49.47 µM -0.14687405654143 0.431733569386462 no 1947 0.441615714849768 626 25237525
SGTC_2382 9035899 200 µM -0.147048959950982 0.431656838075368 no 1948 0.441546687934891 628 6462679
SGTC_479 n-linoleoylglycine 10 µM -0.147554814668803 0.431434930706127 no 1949 0.441347058655693 627 6433346 An anti-infammatory.
SGTC_1415 3966-0071 78.1 µM -0.147605555414421 0.431412673046917 no 1950 0.441327035272302 630 2893185
SGTC_761 k216-0224 480 µM -0.148033348520732 0.431225028316935 no 1951 0.441158224930585 656 1340404
SGTC_3047 9092122 49.47 µM -0.148227110306999 0.431140042856058 no 1952 0.441081768604148 637 17173831
SGTC_2720 fluspirilene 36.88 µM -0.148580276181707 0.43098514969768 no 1953 0.440942418781639 627 3396 An atypical antipsychotic.
SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.149380214756434 0.430634348143772 no 1954 0.440626811447606 609 23665772 A membrane-active detergent.
SGTC_903 1134-0042 114 µM -0.150270877641869 0.43024382515219 no 1955 0.440275454170973 613 701009
SGTC_404 fumagillin 50 µM -0.150328796246142 0.430218432327963 no 1956 0.440252607507306 612 12015870 A methionine aminopeptidase binder.
SGTC_3040 9091894 49.47 µM -0.150533361792351 0.430128748482693 no 1957 0.440171915852987 607 25236966
SGTC_3235 9132602 49.47 µM -0.151418838848436 0.429740586971423 no 1958 0.43982266477328 629 4912240
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.151637716034531 0.429644649484466 no 1959 0.439736342139367 632 390807
SGTC_476 mead acid 10 µM -0.152164693498235 0.429413683609012 no 1960 0.43952852007543 611 5312531 An omega 9 fatty acid.
SGTC_2988 9073640 71.4286 µM -0.152726962667964 0.429167276581405 no 1961 0.43930679853468 637 9102229
SGTC_3132 9126706 49.47 µM -0.153205531076141 0.428957572043927 no 1962 0.439118098000048 617 850858
SGTC_2465 5809242 33.21 µM -0.153286605698281 0.428922047830314 no 1963 0.439086131474478 611 2731748
SGTC_1267 0828-0272 9.49 µM -0.153489774936123 0.428833028330662 no 1964 0.439006026591573 631 745334
SGTC_680 0417-1641 114 µM -0.153510530894291 0.428823934219574 no 1965 0.438997843142864 612 2835990
SGTC_158 k038-0087 26.446 µM -0.153758943498007 0.428715096511242 no 1966 0.43889990356497 607 X158
SGTC_2834 9001755 58.44 µM -0.153958372816528 0.42862772390891 no 1967 0.438821278927648 659 2989575
SGTC_526 4469-0568 170 µM -0.154221304874056 0.428512535269616 no 1968 0.43871762214371 616 2901964
SGTC_786 4544-0069 423 µM -0.156676415327829 0.427437264268353 no 1969 0.43774993766903 609 748821 YLR208W SEC13
SGTC_98 0074-0023 107.663 µM -0.157063163344823 0.427267928170158 no 1970 0.437597534298798 662 3563821
SGTC_973 1325-0077 65.9 µM -0.157235005596786 0.427192692013821 no 1971 0.437529820467322 638 2835149
SGTC_558 k064-0027 21.3 µM -0.157332210635643 0.427150134773467 no 1972 0.437491517975682 626 5088526
SGTC_2757 clomiphene 4.22 µM -0.157653293161487 0.427009567983655 no 1973 0.437365003382948 615 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_1747 st037496 66.6 µM -0.158187951577664 0.426775520331536 no 1974 0.437154348733046 605 723305
SGTC_2566 crystal violet carbinol 226 nM -0.158881506961786 0.426471953675691 no 1975 0.436881115458626 656 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_1754 st042065 16.137 µM -0.158895213276294 0.42646595491023 no 1976 0.436875716018051 624 1126236 YIL048W NEO1
SGTC_1970 st070122 35.8 µM -0.160484235499773 0.425770612163166 no 1977 0.436249819461388 658 102928
SGTC_1393 3470-5649 58.2 µM -0.160725278966136 0.425665153676086 no 1978 0.436154889269809 620 4108395
SGTC_2717 st081029 62.2815 µM -0.16084821108797 0.425611371914705 no 1979 0.436106476305982 648 5292846
SGTC_3323 9138564 53.9225 µM -0.161374517898718 0.425381132803975 no 1980 0.435899217692754 615 43912313 YNL103W MET4
SGTC_1686 st019653 115.5 µM -0.161870929196641 0.4251639951529 no 1981 0.435703748005069 646 97252
SGTC_2090 5301565 104.445 µM -0.161913591228701 0.425145335206793 no 1982 0.435686949897078 638 2056344
SGTC_809 3998-0021 90 µM -0.161951409242632 0.42512879412598 no 1983 0.43567205921062 620 715485
SGTC_504 lovastatin 124 µM -0.162155887407786 0.425039360463593 no 1984 0.435591548359605 661 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_2128 5255449 168.493 µM -0.162980477701741 0.424678744375937 no 1985 0.435266902838815 618 736008
SGTC_1364 1653-0028 37.6 µM -0.163417962318307 0.424487445854617 no 1986 0.435094680551701 608 5718652
SGTC_1763 st044482 94.5 µM -0.164404687292474 0.42405604683927 no 1987 0.434706286928382 617 88505
SGTC_3292 9120825 59.784 µM -0.167725423163596 0.422604882744561 no 1988 0.433399647361866 621 24824900
SGTC_104 0074-0074 590.992 µM -0.16825220068321 0.422374776535616 no 1989 0.433192438012751 645 3943124
SGTC_669 0108-0021 26.2 µM -0.16864800807796 0.422201897936402 no 1990 0.43303675819346 706 17201
SGTC_208 k072-0098 12.366 µM -0.168650099733754 0.422200984394153 no 1991 0.433035935526468 628 5948901
SGTC_2043 5101342 149 µM -0.168707266302709 0.422176016740713 no 1992 0.4330134515143 623 678451
SGTC_3123 9126162 49.47 µM -0.168853224102637 0.422112270696122 no 1993 0.432956046272559 607 25239884
SGTC_506 n9-isopropylolomoucine 153 µM -0.169439191432461 0.421856374132857 no 1994 0.432725599417996 639 6610355
SGTC_2783 7738165 71.43 µM -0.169617351548464 0.421778576737743 no 1995 0.432655537862339 617 17201110
SGTC_1569 carminic acid 40.6 µM -0.169671552758031 0.421754909234962 no 1996 0.432634223629211 606 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2070 5230947 200 µM -0.16980983034226 0.421694530218826 no 1997 0.432579847858701 663 2835538
SGTC_3231 9132313 49.47 µM -0.170421735423603 0.421427363499136 no 1998 0.432339239886781 644 4905967
SGTC_2870 9038528 12.99 µM -0.17058032452601 0.421358127071353 no 1999 0.432276884955406 647 6463316
SGTC_1998 st075797 76.8 µM -0.170675887943441 0.421316407411061 no 2000 0.432239311622217 635 24208315
SGTC_2941 9056145 11.23 µM -0.171544639586282 0.420937181269677 no 2001 0.431897766649173 640 2119517
SGTC_1336 1486-0901 104 µM -0.171911452480071 0.420777082667869 no 2002 0.431753571426805 617 5006114
SGTC_1525 8-methoxypsoralen 92.5 µM -0.172336108407373 0.420591754348496 no 2003 0.431586649296207 678 4114 Related to psoralen; DNA damaging agent.
SGTC_1316 1272-0050 65.9 µM -0.172760382245081 0.420406610356586 no 2004 0.431419889554946 619 7340392
SGTC_2476 5806916 10.51 µM -0.17348073214727 0.420092305475841 no 2005 0.431136785886153 631 2870194
SGTC_3090 9117696 49.47 µM -0.174715083770683 0.419553848638453 no 2006 0.430651757472355 654 7923821
SGTC_1102 cgs 12066b 26.1 µM -0.174878523818 0.419482563033963 no 2007 0.430587542863027 605 6438352 A 5-HT1B full agonist.
SGTC_1967 st070177 51.4 µM -0.175080346263503 0.419394540304541 no 2008 0.430508250573517 647 5729214
SGTC_1097 itavastatin 7.23 µM -0.175366843236213 0.419269594601809 no 2009 0.4303956960476 617 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_3030 9087619 49.47 µM -0.176362582173246 0.418835401043723 no 2010 0.430004549481156 619 25236973
SGTC_2290 7904846 200 µM -0.177064531741798 0.418529374181929 no 2011 0.429728850625295 639 2962154
SGTC_2259 7964009 200 µM -0.178461753546684 0.41792037846829 no 2012 0.429180177623163 632 313134
SGTC_371 0195-0006 7.36 µM -0.179226720222829 0.417587041918384 no 2013 0.428879841852314 617 3928593
SGTC_9 0092-0002 10.449 µM -0.180050257619419 0.417228249188972 no 2014 0.428556556490451 624 759368
SGTC_1412 3909-8563 178 µM -0.181890783056795 0.416426632114743 no 2015 0.427834218948491 639 23767530
SGTC_1360 1598-0022 39.8 µM -0.182458366841201 0.416179498273072 no 2016 0.427611512163197 659 761525
SGTC_3350 9150499 3.57 µM -0.183177837694545 0.415866278333194 no 2017 0.427329241549848 625 4910996 YPR165W RHO1
SGTC_1545 lovastatin 49.4 µM -0.184167782438617 0.415435395607241 no 2018 0.426940916516301 617 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.184221348634117 0.41541208331367 no 2019 0.426919906152384 645 23847180
SGTC_3017 9080681 49.47 µM -0.184297750122327 0.415378833494322 no 2020 0.426889939419846 632 16451914
SGTC_1060 3448-7350 82 µM -0.1846302381642 0.415234142229465 no 2021 0.426759533522315 647 570178
SGTC_2847 9005661 71.43 µM -0.184828524772969 0.41514785785922 no 2022 0.426681766886308 609 2991449
SGTC_1319 1306-0155 43.7 µM -0.187204076612322 0.41411445639613 no 2023 0.425750314335166 616 3122360
SGTC_61 0978-8327 98.565 µM -0.187281534123835 0.41408077115865 no 2024 0.42571995023242 661 6150059 YHR072W ERG7
SGTC_2822 7994718 71.43 µM -0.188253894764586 0.413657958350338 no 2025 0.425338812871798 617 1018011
SGTC_1121 fusaric acid 630.51 nM -0.188446825166271 0.413574078063553 no 2026 0.425263197994983 625 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_3306 9127676 59.7925 µM -0.188512379043519 0.413545578123562 no 2027 0.425237506203474 622 41905287
SGTC_693 4161-2696 114 µM -0.189692869483778 0.41303243093985 no 2028 0.424774904344648 623 805759
SGTC_88 0180-0332 8.668 µM -0.190477215646285 0.412691565728937 no 2029 0.424467597808934 623 3101745
SGTC_1511 0906-3109 28.5 µM -0.190701101878316 0.412594280158238 no 2030 0.424379887680595 637 2882180
SGTC_2050 5263056 171 µM -0.190923563786046 0.412497618819019 no 2031 0.424292739257526 651 763468 YGL055W OLE1
SGTC_215 1287-0124 461.5 µM -0.191377098098857 0.412300571259729 no 2032 0.424115080758464 642 5560863
SGTC_1810 st050138 53 µM -0.192620986046935 0.411760251466224 no 2033 0.42362790411058 652 3444541
SGTC_726 3448-4391 34.2 µM -0.193576080064386 0.411345491390297 no 2034 0.42325391462197 664 1356692
SGTC_2170 morpholine 200 µM -0.193689536304914 0.41129622834456 no 2035 0.423209492754862 643 121171 Reacts with secondary amines.
SGTC_575 k072-0246 11.9 µM -0.193976096316943 0.411171809342203 no 2036 0.423097299389011 628 6796779
SGTC_3315 9136395 68.55 µM -0.194531576467693 0.410930655696314 no 2037 0.422879836751511 674 16876844
SGTC_273 hydroxyurea 18.1 mM -0.195391976018509 0.410557192194451 no 2038 0.422543048881823 624 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_1845 st056753 3.01 µM -0.195849022422423 0.410358840397488 no 2039 0.422364169328193 627 5375839
SGTC_896 0964-0007 44.5 µM -0.196129453765978 0.410237148432626 no 2040 0.422254421583372 626 6756758
SGTC_527 4476-4215 268 µM -0.197208441772762 0.409769006971993 no 2041 0.421832212380446 615 4418754
SGTC_2825 7998094 58.44 µM -0.197599723859378 0.409599272812995 no 2042 0.421679125436095 661 2987815
SGTC_417 st075190 100 µM -0.198263009428925 0.409311585048382 no 2043 0.421419645688145 632 222757
SGTC_1032 k061-1018 98.7 µM -0.198264235706018 0.409311053218706 no 2044 0.421419165995613 670 4005393
SGTC_1476 4112-3294 3.34 µM -0.19840755656235 0.409248896896293 no 2045 0.42136310284362 616 704369
SGTC_3079 9117512 49.47 µM -0.201793681595434 0.4077810471548 no 2046 0.420039010648563 645 7185044
SGTC_1713 st033146 12.748 µM -0.201946913678395 0.407714653090854 no 2047 0.419979112876419 675 674619
SGTC_1152 3909-8331 15.9 µM -0.20253042584383 0.40746184687087 no 2048 0.419751037422146 638 16001939
SGTC_2210 7115885 190.385 µM -0.203253097189614 0.407148803465126 no 2049 0.419468606651428 652 2927039
SGTC_2365 9042475 200 µM -0.203557590850623 0.407016922065564 no 2050 0.419349618387555 629 6464479
SGTC_791 1348-1292 225 µM -0.204927790386828 0.406423595930014 no 2051 0.418814271187443 630 5437054
SGTC_1049 3226-0134 66 µM -0.204930714948354 0.406422329760639 no 2052 0.418813128699796 616 5702385
SGTC_829 1635-0120 117 µM -0.20511532216921 0.406342407278428 no 2053 0.418741012789925 634 285054
SGTC_1313 1220-0047 237 µM -0.205719973221608 0.406080661469294 no 2054 0.418504827938791 633 3528706
SGTC_138 0850-0259 40.9225 µM -0.205962858432323 0.40597553133702 no 2055 0.418409961967394 651 6813004
SGTC_3056 9094900 49.47 µM -0.207608568991957 0.405263382995672 no 2056 0.417767306529524 647 25236784
SGTC_1162 k048-0130 20.1 µM -0.209377055687017 0.404498455282794 no 2057 0.417076951361744 661 6797406
SGTC_3114 9122766 49.47 µM -0.209636006861968 0.404386481078187 no 2058 0.416975887309039 636 17176985
SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.210035798604966 0.404213620772749 no 2059 0.416819866455256 616 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_2640 pentamidine 10.38 µM -0.21118680175472 0.40371605930506 no 2060 0.416370754590181 651 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1477 0139-0234 16 µM -0.211588297194245 0.403542535428838 no 2061 0.416214120055523 631 620880
SGTC_2647 atorvastatin 60.16 µM -0.212145301360544 0.403301833078653 no 2062 0.415996839282103 660 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_1847 st056231 15 µM -0.21220576790054 0.40327570542576 no 2063 0.415973253539746 632 5393180
SGTC_2933 9026794 32.47 µM -0.213345007165216 0.402783519816973 no 2064 0.415528935443304 664 17586027
SGTC_1805 st050013 60.3 µM -0.213798103566187 0.402587811318286 no 2065 0.415352251949283 651 4037144
SGTC_3264 9137442 49.47 µM -0.214892531354536 0.402115189692752 no 2066 0.414925553993438 659 17015726
SGTC_1559 coumarin 343 70.1 µM -0.216484099194277 0.401428136823331 no 2067 0.414305209155533 664 108770 A hepatotoxic, DNA x-linker.
SGTC_1948 st076329 66.6 µM -0.217253310863607 0.401096190239831 no 2068 0.414005470301194 635 24208413
SGTC_493 zm226600 134 µM -0.218294245207341 0.400647097808779 no 2069 0.413599929004075 681 5240098 A potassium channel opener. YCR052W RSC6
SGTC_2893 9048488 25.97 µM -0.218298304923279 0.400645346573881 no 2070 0.413598347545073 625 6467338
SGTC_3214 9129694 49.47 µM -0.218581823763387 0.400523050326211 no 2071 0.413487906482408 657 17158655
SGTC_1703 st026983 48.3 µM -0.218965085942928 0.400357745152387 no 2072 0.413338622584885 652 1104023
SGTC_1480 1070-0044 41.2 µM -0.219778222945413 0.400007089397499 no 2073 0.413021940276604 632 3124987
SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.21984298139323 0.399979166541467 no 2074 0.412996722043305 640 688801
SGTC_1157 4092-0394 27.6 µM -0.219902130276635 0.399953662891001 no 2075 0.412973688600171 643 3659885
SGTC_1322 1348-1070 12 µM -0.220286856568873 0.399787788101475 no 2076 0.41282387785178 646 6758089
SGTC_2676 harmalol 100 µM -0.220368295346546 0.399752678080193 no 2077 0.412792167572687 634 5459187 A monoamine oxidase inhibitor
SGTC_625 k213-0058 121 µM -0.220704532523388 0.39960772753361 no 2078 0.412661251022102 638 3655420
SGTC_100 0086-0128 49.5915 µM -0.221272287723605 0.39936300187721 no 2079 0.412440213193812 686 93297
SGTC_774 k060-0086 136 µM -0.221326708773849 0.399339546259291 no 2080 0.412419027507817 699 5911235
SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.224283886332821 0.398065543324171 no 2081 0.411268206846659 644 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_2926 9010726 65.15 µM -0.224556737746627 0.397948048763803 no 2082 0.411162061791784 686 2994293
SGTC_1092 toremifene 6.32 µM -0.225658163642388 0.397473849817679 no 2083 0.410733649673768 687 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2229 7354935 190 µM -0.225886083306925 0.397375742032322 no 2084 0.410645011009189 662 318112
SGTC_709 3807-1509 243 µM -0.226300409071141 0.397197412564666 no 2085 0.410483890125033 667 1886677 YPL242C IQG1
SGTC_2840 9008771 71.43 µM -0.226527847659811 0.397099530121189 no 2086 0.41039545139042 611 2992978
SGTC_193 1273-0060 1.558 µM -0.227059391424321 0.396870795620895 no 2087 0.41018878015033 675 2847393 YHR072W ERG7
SGTC_853 0419-0306 21 µM -0.228216635163224 0.396372932010432 no 2088 0.409738914829506 648 762713
SGTC_124 0136-0217 7.121 µM -0.228909799315356 0.396074803241868 no 2089 0.409469512013019 664 3976905
SGTC_2623 humulene 100 µM -0.229417584673236 0.395856444146303 no 2090 0.409272185004914 655 6187145 An anti-inflammatory.
SGTC_1788 fluconazole 20 µM -0.229678489891342 0.395744261753997 no 2091 0.409170805342235 659 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_2705 st078069 42.8 µM -0.229798770876262 0.395692546996932 no 2092 0.409124069933531 673 1530061
SGTC_1836 st055642 81 µM -0.230729851216902 0.39529229159976 no 2093 0.408762340621728 679 8571
SGTC_592 k241-0073 46.5 µM -0.231094495390229 0.395135567424049 no 2094 0.408620695716804 668 4230158
SGTC_868 0527-0199 213 µM -0.231509224552964 0.394957337323344 no 2095 0.408459609960333 643 2849450
SGTC_590 k048-0076 22.4 µM -0.232435989656764 0.394559138958868 no 2096 0.408099699266781 667 6832814
SGTC_1378 2093-0007 380 nM -0.233227106573904 0.394219310973456 no 2097 0.407792529081526 646 3618014
SGTC_927 2425-1185 123 µM -0.233623021451009 0.394049274089894 no 2098 0.407638826866515 659 730375
SGTC_2541 muurolladie-3-one 83.07 µM -0.233902494081134 0.393929258791326 no 2099 0.407530338460133 666 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_642 0335-0876 158 µM -0.235103207166098 0.393413745437218 no 2100 0.407064314749831 625 6812350
SGTC_1253 0550-0034 176 µM -0.235669258054008 0.393170782260062 no 2101 0.406844663272319 640 5969915
SGTC_2265 7929201 200 µM -0.236421545761516 0.392847945990629 no 2102 0.406552789457102 687 1265108
SGTC_253 dyclonine 31.25 µM -0.237602727827098 0.392341203039156 no 2103 0.406094617300176 638 3180 An oral anasthetic.
SGTC_1848 st056003 16.4 µM -0.238241104535092 0.392067406780955 no 2104 0.405847048978232 630 146492
SGTC_429 1112-0049 25.5 µM -0.239742907419361 0.391423502722146 no 2105 0.405264784731467 634 2836170
SGTC_2730 imipramine 71.33 µM -0.239831246460533 0.391385636245688 no 2106 0.405230541302284 657 3696 A tricyclic antidepressant.
SGTC_808 0711-0032 135 µM -0.240765446736093 0.390985254928767 no 2107 0.404868455709556 656 4252555
SGTC_695 3505-6186 243 µM -0.240923394074265 0.390917572965648 no 2108 0.404807245125102 668 1819379
SGTC_627 1391-0720 175 µM -0.241888273701523 0.390504184519249 no 2109 0.404433368300601 671 997839
SGTC_11 0438-0307 1.3 µM -0.242035135333683 0.39044127465834 no 2110 0.404376469196356 662 4011476
SGTC_1215 3852-0577 11.2 µM -0.243471143100496 0.389826295675359 no 2111 0.403820218546992 635 2884876
SGTC_1612 st002233 45.4 µM -0.244146030383498 0.389537366268416 no 2112 0.403558861929766 636 1035021
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.244478732815641 0.389394953802749 no 2113 0.403430035539523 686 6708760
SGTC_3273 9137859 49.47 µM -0.245383203550815 0.389007872436441 no 2114 0.403079866574648 641 2377234
SGTC_360 0957-0399 1.01 µM -0.246514003727294 0.388524085071212 no 2115 0.402642182726963 687 6752301 YPR165W RHO1
SGTC_3351 9150312 21.596 µM -0.247413846321627 0.38813923117563 no 2116 0.402293979707885 656 4904905
SGTC_2586 curcumin 80 µM -0.24779329125144 0.387976979179361 no 2117 0.40214717294683 667 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_2452 5863136 48.41 µM -0.248133380748724 0.387831572321621 no 2118 0.402015604481563 649 2184096
SGTC_741 4582-0002 126 µM -0.248283656132741 0.387767326386154 no 2119 0.401957471845061 626 2912688
SGTC_1420 4'-methoxyflavone 42 µM -0.248620299324253 0.38762341538662 no 2120 0.401827252426819 661 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_879 0831-1030 162 µM -0.249358538994464 0.387307880693385 no 2121 0.401541726708039 646 1549252
SGTC_1668 st014914 51.6 µM -0.249721217337925 0.387152893790723 no 2122 0.401401474439179 642 2839556
SGTC_2198 6589944 200 µM -0.250669216718527 0.386747860913078 no 2123 0.401034931213109 659 5290268
SGTC_34 0469-0683 81.75 µM -0.251374349696479 0.386446672694801 no 2124 0.40076234855904 651 3690923
SGTC_2761 levamisole 97.89 µM -0.252903145040287 0.385793903128089 no 2125 0.400171529536006 675 26879 An alkaline phosphatase inhibitor.
SGTC_3179 9107801 49.47 µM -0.253568487039675 0.38550991428012 no 2126 0.399914472380915 646 4818259
SGTC_1318 1280-3875 124 µM -0.254569002077788 0.385082978632877 no 2127 0.399528001645286 682 373245
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.255271905375836 0.38478312189473 no 2128 0.399256548769377 662 91467 include heat shock
SGTC_753 1322-0200 289 µM -0.256369003184162 0.384315240555081 no 2129 0.398832960049734 674 5403907
SGTC_1301 naphtanilide LB 4.81 µM -0.257162683151761 0.383976863388547 no 2130 0.398526594985976 678 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_1268 0828-0275 2.46 µM -0.257752957803362 0.383725263278373 no 2131 0.398298786083985 676 745337
SGTC_1232 0279-0259 161 µM -0.258183297466464 0.383541865132943 no 2132 0.398132723871323 657 1560000
SGTC_3260 9137109 49.47 µM -0.258789496123958 0.383283565307468 no 2133 0.397898831374657 679 17478346
SGTC_53 0973-0023 39.979 µM -0.259537784882297 0.382964792772968 no 2134 0.39761016618801 687 674768
SGTC_1320 1313-0481 95.3 µM -0.260101081949656 0.382724879344783 no 2135 0.39739290168369 674 6813365 YLR208W SEC13
SGTC_1354 1498-1681 81 µM -0.260633012568938 0.382498366479921 no 2136 0.39718776448399 679 5754243
SGTC_2534 helenine 20.12 µM -0.262527335567224 0.381692030846227 no 2137 0.396457456726708 631 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_162 k030-0015 37.8 µM -0.263756702506693 0.381169014049752 no 2138 0.395983699893664 664 1809920 YMR134W ERG29
SGTC_163 TUB2.036 7.546 µM -0.266512423750071 0.379997420999328 no 2139 0.39492229626834 641 15992207 YJR013W GPI14
SGTC_2471 5466956 24.79 µM -0.266639896652646 0.379943252527209 no 2140 0.394873217140243 660 724419
SGTC_1806 st050005 60.3 µM -0.266713528106945 0.379911964571035 no 2141 0.394844868600101 664 5194765
SGTC_298 1391-0729 10 µM -0.267834950847323 0.379435539592592 no 2142 0.39441318318351 655 3237558
SGTC_2852 9023854 51.95 µM -0.268533373668491 0.379138914238619 no 2143 0.394144394702098 695 19798528
SGTC_1008 4106-0037 6 µM -0.270187729700122 0.378436581111203 no 2144 0.393507916026421 714 2905394
SGTC_1217 1183-1422 255 µM -0.270460401405125 0.378320860718672 no 2145 0.393403038585459 654 2849664
SGTC_2485 5633444 17.78 µM -0.270581815665922 0.378269336675852 no 2146 0.39335634162984 641 5724239
SGTC_1778 st046819 58.9 µM -0.271348346384011 0.377944097367674 no 2147 0.393061562848921 650 671715
SGTC_2944 9067346 25.62 µM -0.271745793410134 0.377775494461467 no 2148 0.392908743849202 696 6473075
SGTC_2927 9011802 47.9 µM -0.272151594696968 0.377603371576063 no 2149 0.392752729651685 674 43912568
SGTC_3267 9137951 49.47 µM -0.272928051735471 0.377274100746359 no 2150 0.392454261336661 657 16643986
SGTC_486 niguldipine 82 µM -0.273231090825082 0.377145615657261 no 2151 0.3923377909507 650 1236 A calcium channel blocker.
SGTC_2563 tomatine 8.54 µM -0.273596730543906 0.376990606727129 no 2152 0.3921972734063 737 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_2635 hydroquinidine 100 µM -0.274013623431342 0.37681389376777 no 2153 0.392037076111714 644 442912 An experimental heart treatment.
SGTC_996 3970-0799 1.8 µM -0.275180496905117 0.376319415614622 no 2154 0.391588784989406 663 6615648 YGL040C HEM2
SGTC_841 0251-0215 91.2 µM -0.277363266558736 0.375394983332436 no 2155 0.390750592278083 689 3888614
SGTC_2680 butyl paraben 22.24 µM -0.277892659669152 0.375170885777394 no 2156 0.390547379400256 667 7184 An antifungal and steroid mimetic.
SGTC_3082 9117008 49.47 µM -0.279166667421634 0.374631757987001 no 2157 0.390058461325604 654 41448529
SGTC_1483 3453-0561 55.9 µM -0.280926995212323 0.373887235140197 no 2158 0.389383197444571 683 4546991
SGTC_1425 4048-4433 7.33 µM -0.281445654698553 0.373667959975302 no 2159 0.389184302622291 686 23734946
SGTC_3270 9137563 49.47 µM -0.281739032112474 0.373543946061659 no 2160 0.389071811509422 652 17015724
SGTC_2925 9010536 32.5 µM -0.282244837117909 0.373330167384351 no 2161 0.388877890101796 676 2994177
SGTC_1366 1683-0113 21.9 µM -0.283607045372549 0.372754623582154 no 2162 0.388355768648417 674 708623
SGTC_3171 9103192 49.47 µM -0.284109794666735 0.372542279683064 no 2163 0.388163120534552 675 13018434
SGTC_2312 7706453 155.7 µM -0.284186829920554 0.372509746079278 no 2164 0.388133603885058 680 976098
SGTC_1516 st013856 110 µM -0.284558293071334 0.372352882170381 no 2165 0.387991283997468 689 5281404 A mutagen and neurotoxin.
SGTC_529 4076-0302 30.3 µM -0.285301343951072 0.372039165311864 no 2166 0.38770664165141 674 5816522
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.286338701111728 0.371601334112055 no 2167 0.387309359614403 663 688662
SGTC_131 0141-0277 33.849 µM -0.287129926182777 0.371267498018148 no 2168 0.387006419353685 699 1547771
SGTC_2298 7976326 193.81 µM -0.291259648771829 0.369526649745898 no 2169 0.385426372915187 682 2235818
SGTC_1015 4130-4525 82 µM -0.292532841072552 0.368990483801944 no 2170 0.384939626955167 678 1363237
SGTC_2174 5790901 200 µM -0.293101137698324 0.368751245276829 no 2171 0.384722423592303 677 786020
SGTC_971 1315-0384 26.7 µM -0.293194575475602 0.368711915198236 no 2172 0.384686715070558 689 6769120
SGTC_698 k064-0052 127 µM -0.29321713566631 0.36870241930862 no 2173 0.384678093532395 682 5088751
SGTC_174 3553-0389 74.3 µM -0.295709478544015 0.367653853292979 no 2174 0.383725978963894 661 738071
SGTC_2045 5106652 78.05 µM -0.295935851219425 0.367558663632025 no 2175 0.383639535674264 667 673349
SGTC_1867 st057372 64 µM -0.296063102721437 0.367505157974982 no 2176 0.383590945609563 673 688837
SGTC_3141 9094609 49.47 µM -0.296242401366718 0.367429772331684 no 2177 0.38352248482698 691 25236309 YDL196W YDL196W
SGTC_2279 7948423 32.93 µM -0.296849671956082 0.367174484980841 no 2178 0.38329064049814 658 1247112
SGTC_2105 5350118 200 µM -0.296905460516064 0.367151035258708 no 2179 0.383269343584725 673 2133313
SGTC_1660 st012960 28.1 µM -0.296932352886277 0.367139731709484 no 2180 0.383259077726443 712 24207266
SGTC_6 0844-0013 19.835 µM -0.297551452311139 0.366879540287885 no 2181 0.383022766200572 680 1584900
SGTC_3346 9158254 43.5805 µM -0.298620603662064 0.36643034775159 no 2182 0.382614771467108 688 17639500
SGTC_2018 5133068 143 µM -0.300429213910512 0.365670896164074 no 2183 0.381924891399077 709 785362
SGTC_1450 4112-4260 37.6 µM -0.300431718446495 0.365669844851239 no 2184 0.381923936323004 659 1633175
SGTC_959 1222-0044 107 µM -0.300500610949665 0.365640926687355 no 2185 0.381897665238831 686 6083612
SGTC_499 genistein 192 µM -0.30058462528395 0.365605662050681 no 2186 0.381865628415689 683 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_380 3970-0968 6 µM -0.300617841540957 0.365591719990395 no 2187 0.381852962427052 666 2891601
SGTC_2482 5981709 142.65 µM -0.301138992204033 0.365372997532183 no 2188 0.38165425436432 698 877755
SGTC_445 e6 berbamine 66 µM -0.301629140339296 0.365167326514398 no 2189 0.381467395622087 688 6610268 A calcium/calmodulin antagonist.
SGTC_2703 st077852 53.4 µM -0.301675888017662 0.365147712749668 no 2190 0.3814495754881 705 6281836
SGTC_1531 st059297 52.4 µM -0.301925170462452 0.365043128117838 no 2191 0.381354553696101 666 7566702
SGTC_1819 st053448 58.6 µM -0.302054650847707 0.364988809527142 no 2192 0.381305201023644 671 2857616
SGTC_2205 7238770 200 µM -0.302701556537295 0.364717465352555 no 2193 0.381058655733282 681 279867
SGTC_1038 k292-0204 154 µM -0.302737399212871 0.364702433145178 no 2194 0.381044996972049 666 4454212
SGTC_2203 7227154 166.4 µM -0.302756201756966 0.364694547551926 no 2195 0.381037831844671 672 896304
SGTC_336 4111-0029 111 µM -0.302956393120077 0.364610592907011 no 2196 0.380961547005257 693 3131175
SGTC_3102 9121669 49.47 µM -0.303183547796037 0.364515338468541 no 2197 0.380874993140103 659 41905072
SGTC_19 0279-0214 38.434 µM -0.304760454966109 0.363854313299629 no 2198 0.380274300971718 662 3566274 YBR002C RER2
SGTC_871 0574-0004 149 µM -0.305549088266606 0.363523877163162 no 2199 0.379973994605621 686 9551173
SGTC_2034 5197015 53.07 µM -0.306793852541268 0.363002529484071 no 2200 0.379500143865904 730 780676
SGTC_1868 st057644 42.7 µM -0.310698883303715 0.361368626694171 no 2201 0.37801477313269 675 688665
SGTC_3319 9138450 16.7555 µM -0.311618371675878 0.360984270037192 no 2202 0.377665285216195 700 2029690
SGTC_2510 benzyl isothiocyanate 8.31 µM -0.311777369056758 0.360917821533851 no 2203 0.377604862120296 675 2346 DNA damaging agent; causes G2/M arrest.
SGTC_1830 st055982 50.3 µM -0.312257069852368 0.360717369462761 no 2204 0.377422581630657 715 455313 An antimicrobial agent.
SGTC_2249 haloperidol 116.36 µM -0.312953015946459 0.360426623225873 no 2205 0.377158179094916 692 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_78 0336-0123 156.75 µM -0.313013944340493 0.360401172936157 no 2206 0.377135034033139 661 6765896
SGTC_2512 diallyl trisulfide 49.23 µM -0.313105528863157 0.360362918493789 no 2207 0.377100244361248 697 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_1181 1222-0449 220 µM -0.314154411811302 0.359924904575206 no 2208 0.376701882590456 686 658318
SGTC_3318 9139014 38.6185 µM -0.315000314524492 0.359571789190878 no 2209 0.376380707528768 696 16643984
SGTC_565 1418-0001 44.5 µM -0.315360004638073 0.359421675706785 no 2210 0.376244165146315 714 2862145
SGTC_3173 9105693 49.47 µM -0.3168376310273 0.358805229249357 no 2211 0.375683404341434 727 17096658
SGTC_2878 9043973 25.97 µM -0.320620800157203 0.357228619072115 no 2212 0.374248886452128 678 6465167
SGTC_508 roscovitine 141 µM -0.320700034540396 0.357195624612956 no 2213 0.374218860554883 691 160355 A CDKinase inhibitor.
SGTC_1072 oxiconazole 14.9 nM -0.323176478961458 0.356164933064768 no 2214 0.373280796508493 680 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1283 0922-0125 16.4 µM -0.323369615466135 0.35608459405622 no 2215 0.37320766890188 675 3360884
SGTC_2390 9097792 176.6 µM -0.323408714857406 0.35606833065657 no 2216 0.373192865187972 679 4497149
SGTC_2395 5646831 180.19 µM -0.323881598033311 0.355871655548282 no 2217 0.373013838169186 729 6808628
SGTC_1851 st056236 18.9 µM -0.324729933936544 0.355518923418911 no 2218 0.372692738684999 694 5393171
SGTC_2080 5212524 12.4 µM -0.325109886610825 0.355360981849372 no 2219 0.372548953316525 691 260183
SGTC_2240 6690706 185.951 µM -0.325833134979401 0.355060405218558 no 2220 0.372275303763746 657 805876
SGTC_1761 st044296 37 µM -0.326111729449555 0.354944647480177 no 2221 0.372169911454823 694 1826700
SGTC_1170 0310-0127 64.8 µM -0.326173951098584 0.354918795825986 no 2222 0.372146374308098 714 774975
SGTC_2575 plumbagin 510 nM -0.327796359077367 0.354244958975796 no 2223 0.371532820201058 716 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_2561 acetosyringone 100 µM -0.328506408620585 0.353950196515112 no 2224 0.371264399768499 704 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_1493 4348-0038 111 µM -0.328729861911639 0.353857452573342 no 2225 0.371179940538799 699 800424
SGTC_576 1073-0113 22.7 µM -0.32972720970384 0.353443610714704 no 2226 0.370803046055436 711 5439563
SGTC_2336 9001819 198.65 µM -0.330895891599995 0.352958895479581 no 2227 0.370361562680229 708 2989602
SGTC_1575 cyproterone acetate 48 µM -0.331722745590176 0.352616098688864 no 2228 0.37004931190398 729 9880 An androgen receptor antagonist and liver toxin.
SGTC_2671 danthron 100 µM -0.332170639498336 0.352430460955369 no 2229 0.369880206274152 688 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_2137 5261020 140 µM -0.332334643763382 0.352362495209084 no 2230 0.369818291551899 688 763655
SGTC_421 streptovitacin 30 mM -0.333270732062238 0.351974656941233 no 2231 0.369464965097983 700 91467 include heat shock
SGTC_228 caffeine 993.056 µM -0.334199640092053 0.351589945760848 no 2232 0.369114457780886 693 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_165 k038-0023 64.381 µM -0.335286478633797 0.351140019904023 no 2233 0.368704496259247 691 46368543
SGTC_3282 9108498 15.4605 µM -0.335487340686388 0.351056890507639 no 2234 0.36862874631998 707 16459645
SGTC_2778 tioconazole 65.09 nM -0.335671554624529 0.350980657417452 no 2235 0.368559279274652 710 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1679 SEC14.276 6.7 µM -0.336811066351334 0.350509227693289 no 2236 0.368129665138005 676 1005053 YMR079W SEC14
SGTC_2777 climbazole 1.536 µM -0.336877889125397 0.350481589444206 no 2237 0.368104476996286 686 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_2864 9034755 47.6 µM -0.337539975501312 0.350207789849523 no 2238 0.367854941158517 680 4930451
SGTC_1199 1638-0010 4.46 µM -0.337615789219748 0.350176442763337 no 2239 0.367826371041514 693 3111136
SGTC_2289 7946404 165.07 µM -0.338187159393317 0.349940228261595 no 2240 0.367611075856263 681 1246120 YPR165W RHO1
SGTC_2659 sanguinarine 24.21 µM -0.339025732856039 0.349593652367487 no 2241 0.367295172457203 711 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_2912 7964298 10.93 µM -0.340806844226121 0.348857948959302 no 2242 0.366624498829387 686 2975850
SGTC_1429 4049-0205 9.46 µM -0.341035119122266 0.348763699043481 no 2243 0.366538571795363 688 22774478
SGTC_2019 4016004 108 µM -0.341955255171124 0.348383888845071 no 2244 0.366192282862551 693 45595336
SGTC_794 k038-0031 316 µM -0.343047141469507 0.347933381429706 no 2245 0.36578149788195 679 6624242
SGTC_716 1683-5115 658 µM -0.343110609620941 0.347907201346337 no 2246 0.36575762488138 729 723597
SGTC_3241 9133421 49.47 µM -0.343702331995977 0.347663155704951 no 2247 0.3655350786157 701 17018221
SGTC_2313 7726885 200 µM -0.344305231647745 0.347414565101153 no 2248 0.36530837513291 692 726423
SGTC_970 1315-0089 19.5 µM -0.344796216243049 0.347212168344124 no 2249 0.365123788924162 672 6811083 YLR033W RSC58
SGTC_1158 4092-0494 91.8 µM -0.345169595204099 0.347058280881469 no 2250 0.364983437599042 710 1148199
SGTC_1972 st070201 17.4 µM -0.345441058050925 0.346946413791608 no 2251 0.364881407397225 686 2829099
SGTC_1456 k015-0012 13 µM -0.346254289767094 0.346611369104914 no 2252 0.364575808875975 703 2989616
SGTC_1892 st058411 7.36 µM -0.347372454973175 0.34615089024151 no 2253 0.364155762100422 702 3934738
SGTC_860 0443-0016 25.1 µM -0.347832774057332 0.345961389283856 no 2254 0.363982887309521 700 5337942
SGTC_1342 1486-1464 234 µM -0.34804192504566 0.345875300202384 no 2255 0.363904348908598 701 3253938
SGTC_122 0236-0016 402.397 µM -0.350076984119645 0.345038061729123 no 2256 0.363140461665823 701 6808838
SGTC_3156 9099931 49.47 µM -0.350646644016401 0.344803835019238 no 2257 0.362926729372753 677 18111053
SGTC_1715 st032160 10.2275 µM -0.350705728908593 0.34477954452292 no 2258 0.362904563588873 719 5289825
SGTC_585 0kpi-0023 191 µM -0.351386582911514 0.34449968359859 no 2259 0.362649173370167 707 64601
SGTC_574 1315-0397 40 µM -0.352830890071845 0.343906291761096 no 2260 0.362107612147532 692 6794277
SGTC_2911 7942208 15.64 µM -0.353210020423962 0.343750590133057 no 2261 0.361965498108997 697 1243384
SGTC_2812 7970281 58.44 µM -0.353867438397896 0.343480663896694 no 2262 0.361719115256712 725 2233435
SGTC_1468 k284-1086 134 µM -0.353913439320088 0.343461779574454 no 2263 0.361701877473219 703 15996457
SGTC_1161 k007-0610 110 µM -0.356092075894382 0.342567852789444 no 2264 0.360885805665716 722 5843850
SGTC_2721 ifenprodil 61.44 µM -0.356235389085062 0.342509080099705 no 2265 0.360832145681874 685 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_2695 st077686 51.995 µM -0.356514541068137 0.342394610916492 no 2266 0.360727632178515 690 2876092
SGTC_2896 9052656 71.43 µM -0.356527413956246 0.342389332603511 no 2267 0.360722812866098 726 6469436
SGTC_3244 9134489 49.47 µM -0.357056989113854 0.342172215840168 no 2268 0.360524571320442 735 16584271
SGTC_456 gingerol 170 µM -0.357861770106712 0.341842369278191 no 2269 0.360223380800521 736 442793 A herb.
SGTC_2866 9034245 58.44 µM -0.357871508659372 0.341838378585414 no 2270 0.360219736663028 698 6462273
SGTC_227 fluconazole 33.516 µM -0.358210551398297 0.341699455674452 no 2271 0.360092875796599 709 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_1311 1190-0148 100 µM -0.358399960041117 0.341621854732163 no 2272 0.360022010775972 698 1961333
SGTC_140 0062-0056 502.533 µM -0.359323029791229 0.341243767824917 no 2273 0.359676723950376 703 3758964
SGTC_510 ag-490 170 µM -0.36024883030576 0.340864722415607 no 2274 0.359330530659806 714 5328779
SGTC_3212 9128307 49.47 µM -0.36131927023423 0.340426658285898 no 2275 0.358930394915277 712 27243542
SGTC_683 panaxydol 45 µM -0.361571855357734 0.340323322350203 no 2276 0.358835999893934 688 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_151 3013-0144 2.285 µM -0.361875956501726 0.340198926431659 no 2277 0.358722363965472 716 906558 YHR107C CDC12
SGTC_1400 3771-8998 51.5 µM -0.362351577740045 0.34000440320466 no 2278 0.358544659815607 688 670767
SGTC_2088 5278280 127.392 µM -0.362386524206611 0.33999011220921 no 2279 0.3585316041372 700 791502
SGTC_2523 spermine 47.74 µM -0.364387515200758 0.339172211715694 no 2280 0.357784328512301 699 1103 A DNA binding polyamine.
SGTC_2099 5377090 177.372 µM -0.364552264693512 0.339104904428184 no 2281 0.357722826591309 722 2243829
SGTC_2936 9038235 15.59 µM -0.366417989303428 0.338343034076659 no 2282 0.357026599115839 688 4749415
SGTC_1549 4'-methoxyflavonol 74.6 µM -0.367771470993989 0.337790752275267 no 2283 0.356521821629134 720 97141
SGTC_2816 7982706 58.44 µM -0.369251523557444 0.337187223381752 no 2284 0.355970127428683 715 2981853
SGTC_1938 st074717 56.4 µM -0.369387271894296 0.337131889504406 no 2285 0.355919541888691 675 17250979
SGTC_2343 7990716 14.84 µM -0.369540843763568 0.337069294628161 no 2286 0.35586231760879 689 6456862
SGTC_432 NS 1619 61.3 µM -0.37121009612872 0.336389209738802 no 2287 0.355240526939289 691 4552 A K+/calcium channel activator.
SGTC_3234 9132280 49.47 µM -0.371299721131624 0.336352709935989 no 2288 0.355207152821128 700 17612295
SGTC_2238 6671620 73.2395 µM -0.371493373152531 0.336273850373203 no 2289 0.355135045425789 685 729941
SGTC_1467 k284-1082 293 µM -0.372179242055112 0.335994606716772 no 2290 0.354879700103161 732 3334705
SGTC_1548 st061468 90.8 µM -0.372882383437397 0.335708424710188 no 2291 0.354617991984927 705 390799
SGTC_462 ag-879 158 µM -0.373645918630473 0.335397770006716 no 2292 0.354333883089104 728 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_2762 leflunomide 42.06 µM -0.373684220150304 0.335382189472963 no 2293 0.354319633354926 702 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_1766 st045414 44.774 µM -0.374805196970833 0.334926316951377 no 2294 0.353902674471437 697 253960
SGTC_2143 5623677 140.463 µM -0.378811941845914 0.333298868024863 no 2295 0.35241375941649 674 5375313
SGTC_1282 0886-0010 32.4 µM -0.37923845297648 0.33312581287281 no 2296 0.352255399582455 705 2836211 YNL267W PIK1
SGTC_2894 9048625 32.47 µM -0.379311102321689 0.333096339237318 no 2297 0.352228428071337 727 4092861
SGTC_946 3434-1334 87.4 µM -0.383135551330607 0.331546230381694 no 2298 0.350809630488258 702 4047976
SGTC_1186 1319-0216 26 µM -0.383358447800504 0.331455975553069 no 2299 0.350727004047379 698 4565136
SGTC_678 1218-2179 85.9 µM -0.383379902181811 0.3314472888007 no 2300 0.350719051403904 718 6820081 YOR116C RPO31
SGTC_2388 9080168 200 µM -0.383522893153862 0.331389394916234 no 2301 0.350666049625137 711 15943073
SGTC_3170 9103054 49.47 µM -0.384294270831175 0.331077150663011 no 2302 0.350380176911808 740 16432970
SGTC_188 3229-0966 278.469 µM -0.384466500829099 0.331007450096151 no 2303 0.350316360007949 722 5722370
SGTC_579 4491-1009 110 µM -0.384587781474647 0.330958371975895 no 2304 0.350271424057623 741 1271041
SGTC_2607 solasodine 47.35 µM -0.38476905482863 0.33088502227847 no 2305 0.350204263988735 698 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_1437 4092-1038 11.6 µM -0.386862242226798 0.330038514502855 no 2306 0.34942909759477 719 3977136
SGTC_2119 5528445 120.635 µM -0.387683549475468 0.329706606164189 no 2307 0.349125115569721 715 791935
SGTC_459 nigericin 15.3 µM -0.387797217865018 0.329660680821428 no 2308 0.34908305227464 764 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_3129 9127257 49.47 µM -0.389314117841604 0.329048055087149 no 2309 0.348521896986009 750 837894
SGTC_1341 1486-1360 280 µM -0.389570207304023 0.328944674252049 no 2310 0.348427193035866 739 3976547
SGTC_1771 st048882 4.1505 µM -0.389662824928733 0.328907288635455 no 2311 0.348392944616736 714 4580403
SGTC_708 3448-5400 146 µM -0.390905758541082 0.32840573735409 no 2312 0.347933448643263 732 3462195
SGTC_1919 st067113 52.3 µM -0.39266090697305 0.327698022532159 no 2313 0.347284973951509 709 1268243
SGTC_1445 4239-0156 97.7 µM -0.393710667190328 0.327275031313688 no 2314 0.346897332449361 743 4008346
SGTC_2370 9071495 200 µM -0.393799222858844 0.32723935875501 no 2315 0.346864639110088 747 21791103
SGTC_2291 7917025 104.35 µM -0.393949440594696 0.327178850698033 no 2316 0.34680918372721 705 2964612
SGTC_1638 st008370 60.6 µM -0.394254033152687 0.327056174042302 no 2317 0.346696748378073 691 24207134
SGTC_1189 1431-2119 7.28 µM -0.394453226063764 0.326975957891499 no 2318 0.346623226881756 739 3107275
SGTC_3284 9108171 64.8615 µM -0.395116740160034 0.326708814562507 no 2319 0.346378367533061 733 8687505
SGTC_63 0099-0242 26.702 µM -0.395783022661722 0.326440645991653 no 2320 0.34613255113593 731 3898502 YLR359W ADE13
SGTC_3016 9080866 49.47 µM -0.396934433899981 0.325977431937393 no 2321 0.345707905538688 742 17066299
SGTC_3078 9116413 49.47 µM -0.397236527900096 0.325855943601626 no 2322 0.345596524038003 703 17177322
SGTC_3344 9148862 3.898 µM -0.397516235938338 0.325743474355114 no 2323 0.345493408116364 751 4905352
SGTC_1147 3809-1045 12.3 µM -0.399606369124531 0.324903544524398 no 2324 0.344723232296611 700 325925
SGTC_2759 disulfiram 3.38 µM -0.400273910944382 0.32463547686805 no 2325 0.344477390694873 698 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1909 st060837 51.5 µM -0.403068573674274 0.323514199327919 no 2326 0.343448889357254 745 678937
SGTC_798 1287-0182 476 µM -0.403968439816444 0.323153494262173 no 2327 0.343117963661104 739 1649755
SGTC_470 aa-861 153 µM -0.403992702605263 0.323143770992295 no 2328 0.343109042686795 703 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_1195 1502-0147 41.1 µM -0.404395286948604 0.32298245366629 no 2329 0.342961032708557 716 817940
SGTC_945 3381-0768 11.3 µM -0.404890164218785 0.322784199775806 no 2330 0.342779124286782 732 1126236 YIL048W NEO1
SGTC_1148 3909-7663 27.7 µM -0.406129495980708 0.322287929368725 no 2331 0.342323727128378 751 4084526
SGTC_1276 0871-0068 94.2 µM -0.406501221850954 0.322139139421695 no 2332 0.342187179695042 712 3414906
SGTC_682 0kpi-0099 17 µM -0.407635606830946 0.321685257758415 no 2333 0.341770609496931 727 1714895 YML126C ERG13
SGTC_2610 ononetin 44.17 µM -0.411416300301662 0.320174478471896 no 2334 0.340383651762168 728 259632
SGTC_121 0557-0495 61.343 µM -0.411507257815358 0.320138168077372 no 2335 0.340350310238282 730 3104427
SGTC_2818 7996756 12.99 µM -0.411704904756767 0.320059273019896 no 2336 0.340277864778694 715 2241621
SGTC_1962 st076595 64.5 µM -0.412885862633823 0.3195880377543 no 2337 0.339845119698525 718 279619
SGTC_248 streptozotocin 5.23457 mM -0.413181491245497 0.319470119193015 no 2338 0.339736823827181 758 5300 DNA alkylating agent.
SGTC_622 1348-1566 26.3 µM -0.413854103888425 0.319201899533254 no 2339 0.33949047893299 721 7340407
SGTC_2064 5220758 200 µM -0.414497303934829 0.318945497305268 no 2340 0.339254970555584 723 788518
SGTC_22 0964-0034 14.468 µM -0.414834928669362 0.318810942834323 no 2341 0.339131374022556 742 138402
SGTC_2560 caryophyllene 100 µM -0.416102802802629 0.318305866968442 no 2342 0.338667389549575 715 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_1623 st003709 20.3 µM -0.416294490585205 0.318229534742546 no 2343 0.338597261789334 683 16192618
SGTC_1782 st039423 80.636 µM -0.416934787635825 0.317974617237193 no 2344 0.338363053748402 742 2068169
SGTC_2971 9092186 9.93 µM -0.417640599493802 0.317693716633442 no 2345 0.338104954123889 686 25236400
SGTC_466 geldanamycin 89.2 µM -0.41860301914651 0.317310859743868 no 2346 0.337753141366017 717 5288382 HSP90 inhibitor.
SGTC_1029 k015-0030 64.7 µM -0.419228882488398 0.317061991996933 no 2347 0.33752443287904 706 2208316
SGTC_2835 9006588 71.43 µM -0.420452916856614 0.316575507229098 no 2348 0.337077308966197 710 2345538
SGTC_379 3970-0972 5.9 µM -0.420574345817729 0.316527263329459 no 2349 0.337032965072324 717 2898042 YBL034C STU1
SGTC_2734 clemastine 41.6 µM -0.421037892334617 0.316343124344261 no 2350 0.336863706204621 739 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_2826 7992541 19.48 µM -0.423208462279514 0.315481494543995 no 2351 0.336071586615703 769 2985066
SGTC_2928 9011484 9.79 µM -0.423496595462629 0.315367192405455 no 2352 0.335966490996302 737 2994751
SGTC_258 haloperidol 50.781 µM -0.425956316688204 0.314392143624573 no 2353 0.335069838591388 722 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_967 1306-0166 352 µM -0.427793425140222 0.313664745712307 no 2354 0.334400762096898 721 4437607
SGTC_71 0417-1750 47.813 µM -0.428013891570933 0.313577501240969 no 2355 0.334320503319128 674 6811472
SGTC_2165 5727197 32.143 µM -0.431540113314964 0.312183500653806 no 2356 0.333037846099761 737 1361712
SGTC_979 1426-2828 121 µM -0.432492284181162 0.311807544029988 no 2357 0.332691829434959 740 747872
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.432710885997243 0.311721258603561 no 2358 0.332612410145188 723 279621
SGTC_2513 baicalein 25.65 µM -0.433361826953424 0.311464383636596 no 2359 0.33237596407464 750 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_1298 1079-1278 263 µM -0.434289007671453 0.31109865709222 no 2360 0.332039292571354 759 2840950
SGTC_2158 5657123 3.6195 µM -0.436749781580319 0.31012890932651 no 2361 0.331146411076672 783 2858827
SGTC_844 0330-0132 15.3 µM -0.436867517416104 0.310082544715079 no 2362 0.331103715129434 738 2828079
SGTC_1197 1601-0112 267 µM -0.437782161169126 0.309722459032891 no 2363 0.330772101813332 726 7350313
SGTC_956 1185-0240 191 µM -0.438288116152248 0.30952334823051 no 2364 0.330588719747844 735 1416193
SGTC_2264 7948757 110.76 µM -0.438318412315077 0.309511427414759 no 2365 0.330577740272454 732 2971411
SGTC_1632 st005650 90 µM -0.44000854367367 0.30884671889504 no 2366 0.329965459704149 723 2759605
SGTC_46 0329-0187a 2.197 µM -0.440244188262467 0.308754092332894 no 2367 0.329880129324123 755 46494817
SGTC_1964 st076914 61 µM -0.441007809994333 0.308454013494051 no 2368 0.329603671475575 750 24208661
SGTC_2953 9074162 66.49 µM -0.441257248553418 0.308356019850135 no 2369 0.329513386131991 721 16451992
SGTC_2140 5586273 200 µM -0.441596696985332 0.308222687145786 no 2370 0.329390537296719 737 854421
SGTC_1941 st076221 61.8 µM -0.441811257771325 0.308138422386292 no 2371 0.329312895698255 699 2828568
SGTC_944 3370-0224 231 µM -0.442161047269161 0.308001070745207 no 2372 0.329186335620046 721 4580514
SGTC_1501 4491-0275 38.4 µM -0.443164790086707 0.307607080974016 no 2373 0.328823272278786 737 5104718
SGTC_369 0957-0393 4.5 µM -0.443184975026834 0.307599160242094 no 2374 0.328815972848759 776 6997992
SGTC_2874 9043904 71.43 µM -0.443714342719316 0.307391464157047 no 2375 0.32862456223731 737 4463428
SGTC_2024 5144227 134 µM -0.444298637732396 0.307162289165709 no 2376 0.328413343009521 732 3475211
SGTC_546 peri-Naphthalide 147 µM -0.444463282729746 0.307097724910345 no 2377 0.328353834705166 727 223824 A penicillin ester.
SGTC_1850 st056238 17 µM -0.444625565952393 0.307034092658818 no 2378 0.328295184287875 749 5393177
SGTC_268 camptothecin 39.6153 µM -0.445248653962846 0.306789830017497 no 2379 0.328070034767723 753 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1560 lithocholic acid 53.1 µM -0.44726392243208 0.30600039321186 no 2380 0.327342256303316 723 9903 A bile acid which acts as a detergent.
SGTC_795 0685-0265 78 µM -0.447459373417114 0.305923877449617 no 2381 0.327271707488739 727 302754
SGTC_2441 5730946 39.09 µM -0.451397316803345 0.304384047047104 no 2382 0.325851608419414 715 1774275
SGTC_2416 tofa 880 nM -0.451470922784774 0.30435529821354 no 2383 0.325825088625981 742 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2781 5567276 71.43 µM -0.452412091889069 0.303987805432715 no 2384 0.325486068760857 757 2853274
SGTC_1242 0402-0103 60.1 µM -0.453269893451771 0.303653037114447 no 2385 0.32517720454361 734 432868
SGTC_373 0844-0104 25.9 µM -0.455958379227535 0.302604888117991 no 2386 0.324209953931071 739 5375804
SGTC_1626 st003712 1.76 µM -0.457528285162586 0.301993586097242 no 2387 0.323645688291738 771 24207035
SGTC_1991 st073000 8.92 µM -0.459514843993515 0.30122084065659 no 2388 0.322932247454412 759 4301969 YIL048W NEO1
SGTC_1292 0kpi-0043 232 µM -0.462940907355062 0.299890243870906 no 2389 0.321703362276266 766 3333905
SGTC_1563 conessine 56.1 µM -0.463400369898342 0.299712002689348 no 2390 0.321538706784597 761 441082 An anti-amoebic, histamine inhibitor.
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.464576100134983 0.299256115503956 no 2391 0.321117525396274 744 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_3175 9106517 49.47 µM -0.464931527964765 0.299118360988358 no 2392 0.320990245874467 757 41468073
SGTC_606 k015-0008 38.6 µM -0.46756538108261 0.298098446761166 no 2393 0.32004771323756 770 1970475
SGTC_612 0302-0167 22.4 µM -0.467874686398481 0.2979787776393 no 2394 0.319937103368731 747 235821
SGTC_1131 3454-3128 32.3 µM -0.468628586785242 0.297687188043447 no 2395 0.319667570081646 711 710982
SGTC_2173 5763948 167 µM -0.468661969474436 0.297674279474539 no 2396 0.319655637355207 737 2867177
SGTC_2592 piperlongumine 83.33 µM -0.470300982342198 0.297040812969029 no 2397 0.319069997873618 751 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_1227 3909-8010 46.6 µM -0.470630977451622 0.296913346867957 no 2398 0.318952141091251 741 15982272
SGTC_1184 1269-1718 139 µM -0.470707342178121 0.296883853288256 no 2399 0.318924870261269 732 5403821
SGTC_1882 5615643 20 µM -0.472210536495928 0.296303562818052 no 2400 0.318388259873736 734 2253075
SGTC_2965 9082772 38.63 µM -0.473817779319774 0.295683681653535 no 2401 0.317814927478685 717 16459634
SGTC_2722 naftopidil 47.16 µM -0.476161161851098 0.294780955798637 no 2402 0.316979783214158 771 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_1927 st060202 13.8 µM -0.476820019558644 0.294527377415793 no 2403 0.316745144392978 716 688887
SGTC_1363 1636-0063 10.4 µM -0.478108085610932 0.294031922961458 no 2404 0.316286638730855 748 6072185
SGTC_1877 wortmannin 25 µM -0.478345747908796 0.29394054830684 no 2405 0.316202070242213 753 312145 A covalent inhibitor of PI 3-kinase.
SGTC_3352 9151559 45.5865 µM -0.47855428008286 0.293860384205451 no 2406 0.316127875180158 722 17159339
SGTC_3281 9140613 49.47 µM -0.47952496757646 0.293487364925124 no 2407 0.315782605244712 724 16013766
SGTC_216 k038-0035 28.382 µM -0.480238912149204 0.29321314778741 no 2408 0.315528760346774 739 4444231 YPR107C YTH1
SGTC_1002 4049-0206 172 µM -0.480330600261017 0.293177940144631 no 2409 0.315496166697179 743 4662749
SGTC_911 3456-4043 236 µM -0.480469679752672 0.293124538260209 no 2410 0.315446728914126 744 914281
SGTC_2624 nerol 100 µM -0.480758187841034 0.293013775167459 no 2411 0.315344185146474 786 637566 A natural product oil.
SGTC_2651 TUB2.036 5 µM -0.481153757928494 0.292861940749353 no 2412 0.315203611697363 747 15992207 YFL037W TUB2
SGTC_2000 st075254 36.4 µM -0.482550217858603 0.292326220081756 no 2413 0.314707566807107 721 17234175
SGTC_118 0083-0097 135.343 µM -0.483100099679864 0.292115395333475 no 2414 0.314512331648247 770 5207356
SGTC_2468 5987765 72.9 µM -0.483868637843289 0.291820856342427 no 2415 0.314239549604464 722 26772094
SGTC_2806 7952793 58.44 µM -0.485873550945346 0.291053133900307 no 2416 0.313528411004277 753 2972490
SGTC_1799 st045822 46.1415 µM -0.486080686695874 0.290973871164714 no 2417 0.313454979800608 776 3674992
SGTC_2713 st079149 53.4 µM -0.487739010705924 0.290339659451362 no 2418 0.312867358015801 734 3103253
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.488394342061624 0.29008921219745 no 2419 0.312635274356489 726 6708561
SGTC_990 3985-0011 41.3 µM -0.489395752388279 0.289706700028449 no 2420 0.312280771337028 773 5399565 YGL099W LSG1
SGTC_3007 9078383 71.4286 µM -0.49032796473087 0.289350832532216 no 2421 0.311950920763912 740 6496995
SGTC_1402 3909-7673 35.9 µM -0.491601468598653 0.288865010900986 no 2422 0.31150055251882 733 5328014
SGTC_1862 st057513 3.81 µM -0.492028233417896 0.288702292782963 no 2423 0.311349692312191 759 5393163
SGTC_2989 9073649 71.4286 µM -0.492446315187789 0.288542927231266 no 2424 0.311201932254059 794 21367202
SGTC_1530 rhein 70.4 µM -0.492512814722269 0.288517582578286 no 2425 0.311178432537657 741 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_1027 k015-0025 8.67 µM -0.492515313641017 0.288516630197656 no 2426 0.311177549480586 746 3598955
SGTC_2923 7992654 58.14 µM -0.492558607979288 0.288500130220818 no 2427 0.311162250487599 726 2985126
SGTC_171 k064-0041 9.68 µM -0.49265288762877 0.288464200686343 no 2428 0.311128935858414 735 53325
SGTC_3268 9137683 49.47 µM -0.492886498979831 0.288375181578675 no 2429 0.311046393687825 793 1953228
SGTC_1407 3909-7909 12.3 µM -0.494176766267094 0.287883750385748 no 2430 0.310590673338007 745 4411780
SGTC_892 0929-0076 29 µM -0.494972565977543 0.287580847093705 no 2431 0.310309742943907 723 5751038
SGTC_2448 5185112 27.17 µM -0.495770591331075 0.2872772480383 no 2432 0.310028137962272 730 5718189
SGTC_689 0833-0039 98 µM -0.496007233412826 0.287187249596612 no 2433 0.309944653765446 793 5374726
SGTC_1700 st030840 7.9285 µM -0.496494028369187 0.287002156338415 no 2434 0.309772949756655 756 5499307
SGTC_688 0527-0193 473 µM -0.497598363980011 0.286582466216659 no 2435 0.309383578551338 760 4007154
SGTC_1965 Pectolinarigenin 58.4 µM -0.497836990231532 0.286491817300131 no 2436 0.309299470815319 763 5320438 An anti-inflammatory.
SGTC_3006 9075424 71.4286 µM -0.499407690308092 0.285895482299105 no 2437 0.308746101300904 758 7465181
SGTC_1338 1486-1223 76 µM -0.500842300086779 0.285351331790809 no 2438 0.308241056541887 747 3444526
SGTC_346 4513-0042 7.16 µM -0.501851897917035 0.284968685181477 no 2439 0.307885851814245 745 2827372
SGTC_2463 5473429 200 µM -0.503286474102241 0.284425389252044 no 2440 0.307381437363734 744 5399405
SGTC_2220 6782180 200 µM -0.503405718362548 0.284380251914589 no 2441 0.307339526007708 752 833803
SGTC_1757 st041620 31.8375 µM -0.503680533468969 0.284276239632198 no 2442 0.307242944995986 762 5289815
SGTC_2067 5224629 34.075 µM -0.503716792336913 0.284262517699487 no 2443 0.307230203178758 763 2835000
SGTC_2139 5578692 56.4705 µM -0.504179776266515 0.284087332282714 no 2444 0.307067525328288 770 650991 YMR113W FOL3
SGTC_1074 carmofur 3.8 µM -0.504548723796119 0.283947765658534 no 2445 0.306937916065701 778 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_720 r052-1644 49.9 µM -0.504967615359069 0.283789345835386 no 2446 0.30679079098071 777 1422863 YOR257W CDC31
SGTC_2451 5856223 45.7 µM -0.505257752042639 0.283679644393281 no 2447 0.306688906035635 771 2179896
SGTC_1355 1499-0035 1.68 µM -0.505714423843641 0.283507016741722 no 2448 0.306528570560315 763 1548538
SGTC_1708 st033234 31.827 µM -0.506274503860727 0.283295368250626 no 2449 0.306331979463772 754 674664
SGTC_580 1123-0028 41 µM -0.50918588013162 0.282196411450343 no 2450 0.305310969655736 766 1677248 YPR107C YTH1
SGTC_1122 capsaicin 818.572 nM -0.509509851403695 0.282074249043587 no 2451 0.305197447424825 780 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_2369 9071472 200 µM -0.509672096000976 0.28201307976272 no 2452 0.305140602608066 748 17296037
SGTC_2865 9030313 51.95 µM -0.509676218273703 0.282011525671184 no 2453 0.305139158369502 773 42562754
SGTC_3348 9149464 3.537 µM -0.510164084639725 0.28182762981243 no 2454 0.304968255785964 750 1951442
SGTC_1062 mesoridazine 14.2 µM -0.510823212406185 0.281579270669649 no 2455 0.304737426834628 762 4078 A neuroleptic.
SGTC_2756 carbadox 75.1 µM -0.515964688041807 0.279645595971453 no 2456 0.302939536199229 760 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_2869 9037858 32.47 µM -0.519430710067642 0.278345695470503 no 2457 0.301730210183418 739 27187042
SGTC_857 0438-0306 1.35 µM -0.52065805132681 0.277886099255348 no 2458 0.301302500834779 751 4686136
SGTC_1077 5-fluorocytosine 377 nM -0.52188467682566 0.27742714148557 no 2459 0.300875313908095 788 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_2202 7226349 200 µM -0.522311019089112 0.277267706848269 no 2460 0.30072689914035 735 844334
SGTC_66 0109-0187 42.4 µM -0.522775078635258 0.27709421843612 no 2461 0.300565392102858 737 759417
SGTC_2224 6650123 117.647 µM -0.522983859451069 0.277016183170366 no 2462 0.300492742714614 762 2908370
SGTC_1841 st054148 70 µM -0.524979737623215 0.276270734293148 no 2463 0.299798638369221 783 675442
SGTC_3191 9110352 49.47 µM -0.525177573771986 0.276196897294991 no 2464 0.29972987667465 777 17122424
SGTC_2132 5317594 122.667 µM -0.525716838194454 0.275995680610493 no 2465 0.299542481409174 786 794577
SGTC_1365 1672-3266 55.4 µM -0.526185698151166 0.275820792594244 no 2466 0.299379594978112 768 6415873
SGTC_1295 1013-0063 9.78 µM -0.528784534759109 0.274852397095106 no 2467 0.298477463605808 771 6826038
SGTC_3068 9116768 49.47 µM -0.528907691363623 0.274806547297419 no 2468 0.298434743096625 792 41904888
SGTC_175 3793-3120 23.7 µM -0.529153742266882 0.274714956647974 no 2469 0.298349401400399 815 5322297
SGTC_994 3910-0338 138 µM -0.529935360462784 0.274424104884708 no 2470 0.298078374219785 779 3479481
SGTC_2144 5628481 200 µM -0.53222979862497 0.273571189192968 no 2471 0.297283423409263 770 2818399
SGTC_2755 lomerizine 42.69 µM -0.532450985499558 0.273489036372547 no 2472 0.29720684032277 763 3949 A calcium channel blocker.
SGTC_2072 5231554 129 µM -0.533427902893881 0.273126337663412 no 2473 0.296868703264589 775 789545
SGTC_2333 9017922 200 µM -0.534356314034895 0.272781868857962 no 2474 0.296547518764728 769 3163164
SGTC_123 0083-0120 66.675 µM -0.537043495181493 0.271786059148318 no 2475 0.295618785032008 767 16001701
SGTC_2269 7935389 174.42 µM -0.53953722671274 0.270863558858103 no 2476 0.294758108710093 756 97605
SGTC_2963 9082507 9 µM -0.54020737872246 0.270615917759021 no 2477 0.294527012303331 796 16459611
SGTC_788 1182-0090 188 µM -0.541229212882026 0.27023853744451 no 2478 0.294174802234017 757 5715185
SGTC_1885 st057546 99.9 µM -0.541339501148138 0.270197821897165 no 2479 0.29413679925211 763 702008
SGTC_2962 9082311 13.18 µM -0.542491839412988 0.269772592279123 no 2480 0.293739863846291 772 16459453
SGTC_2242 6630449 61.2675 µM -0.543029774644618 0.269574201135373 no 2481 0.293554651130973 764 691249 YDR170C SEC7
SGTC_1827 berberine 7.24 µM -0.543167645275678 0.269523366056899 no 2482 0.293507190566185 768 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2844 9010103 25.97 µM -0.545243780198942 0.268758443676239 no 2483 0.292792932277622 810 2480525
SGTC_812 4251-0442 148 µM -0.545549344022883 0.26864595516142 no 2484 0.292687876499197 786 5723007
SGTC_1473 k844-0725 134 µM -0.545631793302116 0.268615606809952 no 2485 0.292659532644549 776 54682906
SGTC_2317 5986382 200 µM -0.546010842206178 0.268476106726728 no 2486 0.292529242188124 802 877883
SGTC_2582 agaric acid 100 µM -0.547007973691758 0.268109309826486 no 2487 0.292186627035326 774 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_1856 st057054 55.7 µM -0.547644115866815 0.267875435457444 no 2488 0.291968145689001 809 1266018
SGTC_2245 6637752 200 µM -0.548677744439116 0.26749564653163 no 2489 0.291613311002528 755 681890
SGTC_3199 9111318 49.47 µM -0.549136129511863 0.267327307822105 no 2490 0.291456016218677 770 8548020
SGTC_3038 9091290 49.47 µM -0.549635525558929 0.267143968974623 no 2491 0.291284693584527 795 25236843
SGTC_1249 0481-0015 10.2 µM -0.551665788841268 0.266399270549419 no 2492 0.290588676620705 801 4227577
SGTC_2804 7954240 19.48 µM -0.552205458685279 0.266201497069766 no 2493 0.290403797438131 760 828705
SGTC_2469 5655019 90.81 µM -0.553423251089975 0.265755484452279 no 2494 0.289986810639787 780 2788239
SGTC_1666 st014829 29 µM -0.553503464544239 0.265726119831739 no 2495 0.289959354443235 769 3858230
SGTC_2838 9002687 71.43 µM -0.557054613988911 0.264427762125626 no 2496 0.288745057774209 780 6457060
SGTC_1085 doxorubicin 7.67 µM -0.558372860234021 0.263946613046548 no 2497 0.288294900670745 794 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1714 st033236 13.627 µM -0.558590402169373 0.263867254939869 no 2498 0.288220645884457 791 2916566
SGTC_355 1311-2252 105 µM -0.560771531168923 0.263072263975416 no 2499 0.287476648254069 799 5338538
SGTC_1889 st059080 5.18 µM -0.561401687394271 0.262842808970958 no 2500 0.287261866990975 783 176925 Isolated from Daphnopsis sellowiana.
SGTC_2307 7538926 6.34 µM -0.562007584913668 0.262622283693451 no 2501 0.287055425658241 790 96582
SGTC_3076 9116187 49.47 µM -0.562028191966525 0.262614785119831 no 2502 0.287048405661161 777 27241210
SGTC_883 0850-0245 24.6 µM -0.564193247433307 0.26182756732858 no 2503 0.286311311422481 791 6823229 YPR165W RHO1
SGTC_658 3253-0951 102 µM -0.564481527066179 0.2617228397563 no 2504 0.286213234305455 777 1184878
SGTC_2553 4-methylesculetin 85.09 µM -0.564624153003392 0.261671033887575 no 2505 0.286164716692246 781 5319502
SGTC_2035 5154463 94.595 µM -0.566789434861144 0.260885187709881 no 2506 0.285428624725375 800 2769623
SGTC_1966 st070145 16.1 µM -0.566871193631313 0.260855538783493 no 2507 0.28540084833901 787 3748532
SGTC_880 0833-0487 87.2 µM -0.567661114799557 0.260569171782321 no 2508 0.285132550109698 785 76075
SGTC_1224 0823-0416 294 µM -0.568781072840026 0.260163435401413 no 2509 0.284752360414749 792 3598164
SGTC_1088 bifonazole 369 nM -0.570174048202211 0.259659245574804 no 2510 0.284279827997296 784 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_519 k048-0011 62.8 µM -0.570429607969223 0.259566800064283 no 2511 0.284193176379933 773 6836379
SGTC_308 4092-1169 104 µM -0.570601409612007 0.259504662548591 no 2512 0.284134931390829 791 2268590 YDL196W YDL196W
SGTC_849 0386-0493 241 µM -0.571454727503125 0.259196146929251 no 2513 0.283845720233041 798 726119
SGTC_797 k781-0471 270 µM -0.578947296630879 0.256495384899177 no 2514 0.281312367678584 765 23738129
SGTC_1822 st052468 42 µM -0.579619539104588 0.256253787909581 no 2515 0.281085606833871 782 2873678
SGTC_2779 methotrexate 400 µM -0.579920853883715 0.256145537012491 no 2516 0.280983995994107 782 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_2505 galangin 7.89 µM -0.580010824876199 0.256113218493623 no 2517 0.280953658978873 786 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_742 0kpi-0133 140 µM -0.580285420887571 0.256014593894181 no 2518 0.280861078666428 789 2728852
SGTC_1419 3993-2473 62.6 µM -0.581878838558627 0.255442689253793 no 2519 0.280324147640445 795 704026
SGTC_2681 menadione 3.18 µM -0.582200903546271 0.255327175819901 no 2520 0.280215682416133 803 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_2565 isoliquiritigenin 100 µM -0.58290760349483 0.255073803015603 no 2521 0.279977750896697 762 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_2596 sinensetin 100 µM -0.583372714969242 0.254907118607892 no 2522 0.279821210775129 774 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_3258 9138477 49.47 µM -0.583841447429387 0.254739194218087 no 2523 0.279663494923526 800 4970355
SGTC_448 monastrol 171 µM -0.584560243359977 0.254481796621508 no 2524 0.279421723286441 802 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_1768 st044301 37.178 µM -0.584829418412919 0.254385441326864 no 2525 0.279331210659556 833 3931349
SGTC_401 neomycin 50 µM -0.58580076148347 0.254037893399671 no 2526 0.279004705978296 756 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_1164 k060-0068 93.7 µM -0.58715713811452 0.253552997041506 no 2527 0.278549087942056 797 5963676
SGTC_2652 actinonin 100 µM -0.587407745040989 0.253463459845344 no 2528 0.278464946702206 792 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_923 1900-2434 73.3 µM -0.587857505550499 0.253302810452859 no 2529 0.278313970737483 825 5910570
SGTC_3180 9109287 49.47 µM -0.588733165273729 0.252990188289041 no 2530 0.278020143103412 777 18891271
SGTC_409 arachidonic acid 100 µM -0.589194753138869 0.25282547703807 no 2531 0.277865318232272 782 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_714 4296-0578 26.1 µM -0.589897766938514 0.252574724786364 no 2532 0.277629595658597 789 1589775
SGTC_358 0075-0058 9.45 µM -0.590191187118379 0.252470105904675 no 2533 0.277531239922668 850 1069125
SGTC_2665 lovastatin 100 µM -0.590972418949948 0.252191669296317 no 2534 0.277269450627737 800 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_3101 9120531 49.47 µM -0.591143342675595 0.252130772457858 no 2535 0.277212190520932 825 24824904
SGTC_235 0330-0087 5 mM -0.591224042505945 0.252102023355065 no 2536 0.277185157777243 781 46494818 YHR062C RPP1
SGTC_691 1548-0686 185 µM -0.591745949209185 0.251916137224624 no 2537 0.277010361170338 812 46495133
SGTC_2353 9059630 146.67 µM -0.591816330282687 0.25189107532039 no 2538 0.276986793322752 776 4779114
SGTC_2006 4011487 200 µM -0.593627938590885 0.251246435258335 no 2539 0.276380495142578 792 45595294
SGTC_2697 mebhydrolin 72.4 µM -0.593806410107945 0.251182975451449 no 2540 0.276320800609404 785 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_679 0422-0091 41.4 µM -0.594003211587986 0.251113007817967 no 2541 0.276254982467793 816 627384 YHR062C RPP1
SGTC_2663 amphotericin b 100 µM -0.594243622551341 0.251027549961722 no 2542 0.276174590042889 785 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1285 0929-0069 65.5 µM -0.594450438199241 0.250954046403034 no 2543 0.276105440940597 785 1206237
SGTC_3349 9149703 23.001 µM -0.594503529395801 0.250935179301296 no 2544 0.276087691195604 796 4910494
SGTC_1816 st051957 91.6 µM -0.594988378474766 0.250762912462766 no 2545 0.275925619670509 806 674121
SGTC_1596 piperlongumine 63 µM -0.595419348432889 0.250609841455868 no 2546 0.27578159767605 787 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_1652 st011932 78 µM -0.596677857204182 0.250163130408973 no 2547 0.275361239461324 806 1551076
SGTC_2066 5222451 176 µM -0.596926586613882 0.250074893250363 no 2548 0.275278197950213 799 2281147
SGTC_850 0388-0143 75.9 µM -0.597539435148855 0.249857554725661 no 2549 0.275073643205625 810 67273
SGTC_2065 5221596 34.26 µM -0.597966965951552 0.249705996046986 no 2550 0.274930987602404 779 788581
SGTC_2604 4'-hydroxychalcone 11.32 µM -0.598095819795368 0.249660327234583 no 2551 0.27488799966885 804 5282362
SGTC_2171 5739187 198.077 µM -0.59851037116793 0.249513430643826 no 2552 0.274749720435522 773 2262761
SGTC_3083 9117465 49.47 µM -0.598793100473305 0.249413271649912 no 2553 0.274655431916188 816 16420915
SGTC_550 4123-0385 25.7 µM -0.598834831866752 0.249398489798346 no 2554 0.274641516099705 803 5731123
SGTC_2786 7743617 45.45 µM -0.601432353144751 0.248479328158317 no 2555 0.273776027643203 782 583674
SGTC_1193 1488-0126 41.5 µM -0.601472904590183 0.248464992905384 no 2556 0.273762526690413 785 1384710
SGTC_2274 7947094 46.08 µM -0.602734183160559 0.248019341190234 no 2557 0.273342768709358 785 2971028
SGTC_1749 st037932 54.2 µM -0.605175156905903 0.247158076711429 no 2558 0.272531310407178 817 594497
SGTC_1089 terbinafine 2.25 µM -0.607389446287718 0.246378180518099 no 2559 0.271796245331865 812 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_3356 9151811 4.48 µM -0.608072224771382 0.246137965031379 no 2560 0.271569786414355 821 1859254 YPR165W RHO1
SGTC_377 3970-0964 33.1 µM -0.610567689726611 0.245261078772126 no 2561 0.270742909174131 800 16481235
SGTC_2145 5634607 200 µM -0.611016221275807 0.245103646656175 no 2562 0.270594420738909 810 308662
SGTC_951 1171-0579 82.7 µM -0.611664935487246 0.244876047707421 no 2563 0.270379732897651 810 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_613 3914-0030 117 µM -0.611990627377088 0.244761822830292 no 2564 0.270271979349466 790 1145395
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.613641307326086 0.244183346734392 no 2565 0.269726190453645 830 368090
SGTC_2445 5742597 35.57 µM -0.613996340422531 0.244059022792261 no 2566 0.269608872746091 808 1774255
SGTC_2326 6164455 177.58 µM -0.614047780944809 0.244041012406537 no 2567 0.26959187677784 796 2888790
SGTC_2484 5809818 12.04 µM -0.614397290978138 0.243918660734755 no 2568 0.269476412745782 800 2870548
SGTC_2302 7771753 200 µM -0.615115839411351 0.24366722517396 no 2569 0.269239111183209 793 2203047
SGTC_1680 diphenhydramine 100 µM -0.616426450933493 0.243208974641853 no 2570 0.268806550126142 803 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_1683 st010134 710 nM -0.617368011927124 0.242880049083157 no 2571 0.268496008027272 825 3818134
SGTC_2318 6029776 164 µM -0.617415569645037 0.242863441625981 no 2572 0.268480327506256 826 818325
SGTC_325 2810-4341 181 µM -0.618083031250016 0.242630424636893 no 2573 0.26826030359583 795 774970
SGTC_374 0880-0231 82.3 µM -0.618345967367982 0.242538664465394 no 2574 0.268173653511738 804 6833587
SGTC_2888 9058547 12.99 µM -0.61967086911681 0.242076582683085 no 2575 0.267737249129981 784 16476514
SGTC_1515 3460-0031 42.1 µM -0.620077011289185 0.241935029424086 no 2576 0.267603543193015 805 2876596
SGTC_3217 9129673 49.47 µM -0.620638388335576 0.241739445900202 no 2577 0.267418787865163 813 17248312
SGTC_909 3448-9333 149 µM -0.621370250937354 0.241484594200473 no 2578 0.267178020527227 812 3344074
SGTC_275 trichlorophene 5.69 µM -0.621506694013932 0.241437097669013 no 2579 0.267133145740912 802 62616
SGTC_934 2950-0684 338 µM -0.622011462303345 0.241261429370208 no 2580 0.266967165495824 813 1121253
SGTC_424 splitomicin 100 mM -0.623123886390085 0.240874531441566 no 2581 0.266601557044465 817 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.623699974143055 0.240674302498151 no 2582 0.26641232003667 797 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1331 1472-0049 76.2 µM -0.623720171846275 0.240667284092432 no 2583 0.266405686598582 817 24051409
SGTC_1588 farnesol 29.9 µM -0.624651141251308 0.240343906812696 no 2584 0.266100023352764 797 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_924 2046-0044 21.3 µM -0.624870342495712 0.24026780051361 no 2585 0.266028079304795 799 3623589
SGTC_3072 9116419 49.47 µM -0.625032932044996 0.240211358182253 no 2586 0.265974722148137 794 17170162
SGTC_2889 9059656 51.95 µM -0.625423673785346 0.240075743257096 no 2587 0.265846514259211 822 3949838
SGTC_488 nitrendipine 139 µM -0.628538410092506 0.238996204162946 no 2588 0.264825646403927 805 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_1458 k015-0034 6.33 µM -0.629154515789469 0.238782982413315 no 2589 0.264623951525007 815 3598957
SGTC_3037 9091026 49.47 µM -0.629640265836131 0.238614947516189 no 2590 0.264464986357268 816 25236398 YIL048W NEO1
SGTC_2718 lomofungin 53.02 µM -0.630885988399112 0.23818431223818 no 2591 0.264057537005205 813 5351222 A RNA synthesis inhibitor.
SGTC_2393 9031399 185.94 µM -0.631502384632949 0.237971387091431 no 2592 0.263856045262742 824 1526623 YDL150W RPC53
SGTC_1106 tegaserod maleate 11.7 µM -0.632107354254661 0.237762510609123 no 2593 0.263658364977262 811 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_1221 2958-7315 257 µM -0.633796737389977 0.237179754023122 no 2594 0.263106741348395 806 4562705
SGTC_2015 5119600 184 µM -0.633933600896545 0.237132577026701 no 2595 0.263062078006793 827 2828786
SGTC_2639 lactacystin 53 µM -0.633981746252454 0.237115982497186 no 2596 0.26304636741716 795 3870 A proteasome inhibitor.
SGTC_2617 dihydrotanshinone i 20.83 µM -0.634278273342862 0.237013790912134 no 2597 0.262949616519354 811 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_1987 st072290 61.9 µM -0.634593110768379 0.236905315568935 no 2598 0.2628469112384 817 54697379
SGTC_710 3448-4187 58 µM -0.634779651188185 0.236841057066718 no 2599 0.26278606828508 790 3946412
SGTC_1488 4013-0813 75.9 µM -0.635949156257494 0.236438410332292 no 2600 0.262404780896827 801 2910057
SGTC_2247 cerulenin 830 nM -0.635969555250505 0.236431390545673 no 2601 0.262398132838354 790 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_1469 k284-2957 126 µM -0.638101895727981 0.235698233741673 no 2602 0.26170367630893 802 23884841
SGTC_1020 4335-0961 93.3 µM -0.639669348572239 0.235160101281954 no 2603 0.261193793365972 821 669075
SGTC_675 1309-0189 238 µM -0.639694075237011 0.235151617649247 no 2604 0.261185754023263 794 4246530
SGTC_90 0870-0863 4.608 µM -0.640387955922031 0.234913618535777 no 2605 0.260960205520366 835 1738164
SGTC_648 0375-0473 33.3 µM -0.640942944518371 0.234723354870544 no 2606 0.260779876528344 809 1713139
SGTC_2142 5622915 118.518 µM -0.641187324959698 0.234639602304139 no 2607 0.26070049184786 813 5322196
SGTC_1261 0712-0010 12.7 µM -0.643171447627451 0.233960228085408 no 2608 0.260056429005429 817 2840123
SGTC_1522 st012842 45.6 µM -0.643924977065661 0.233702501372135 no 2609 0.259812042163385 815 3491067 YOR116C RPO31
SGTC_92 0063-0024 660.874 µM -0.644031500363882 0.233666080328335 no 2610 0.259777503782178 819 3594437
SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.644113818957812 0.233637937194025 no 2611 0.259750814990712 838 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_1078 idebenone 36.1 µM -0.644380260943357 0.233546858722289 no 2612 0.259664440630888 830 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_2440 5628896 157.78 µM -0.645642002425329 0.233115822264538 no 2613 0.259255614514518 833 5522048
SGTC_64 000l-0018 272.079 µM -0.645787796793277 0.233066044436169 no 2614 0.25920839606052 810 6811119
SGTC_2361 9034121 116 µM -0.646884785984622 0.232691694338995 no 2615 0.258853256534208 847 6496917
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.647263835219386 0.232562420642237 no 2616 0.258730601601793 817 688761
SGTC_2029 5175081 200 µM -0.647670702050772 0.232423704275802 no 2617 0.258598978774028 806 1380876
SGTC_120 rhodamine 6G 52.259 µM -0.64768144159197 0.232420043381524 no 2618 0.25859550496502 839 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_1271 0832-2808 169 µM -0.649201263995771 0.231902289928472 no 2619 0.258104147408188 830 3663794
SGTC_1864 st057645 30.4 µM -0.649435377235404 0.231822592390077 no 2620 0.258028501809918 825 688666
SGTC_2303 7774051 200 µM -0.65019188121346 0.231565165348727 no 2621 0.257784142342478 844 2953184
SGTC_738 1315-0003 72.4 µM -0.650215793800286 0.231557030850207 no 2622 0.257776420261246 839 6251474
SGTC_2858 9025781 8.96 µM -0.650525941858233 0.231451540221608 no 2623 0.257676275162542 805 4894980 YPL153C RAD53
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.650719698438603 0.231385651416359 no 2624 0.257613722483294 815 803109
SGTC_624 k048-0052 28 µM -0.650989151832961 0.231294038565858 no 2625 0.257526744835359 811 6835531
SGTC_2178 5812956 200 µM -0.651773930486731 0.231027332930843 no 2626 0.257273510774131 816 5403383
SGTC_902 1120-0002 2.07 µM -0.652098404391715 0.230917111229685 no 2627 0.257168846671697 809 3280475
SGTC_654 1124-0271 80.9 µM -0.652418760352751 0.230808317177899 no 2628 0.257065532599742 813 5403748
SGTC_1995 st072814 61.1 µM -0.654307846679098 0.230167359026842 no 2629 0.256456745787552 809 5769371
SGTC_2694 st077685 81.9 µM -0.655283971339547 0.229836555071738 no 2630 0.25614246937073 788 2838096
SGTC_1159 4092-0538 61.2 µM -0.655541379547794 0.229749365041087 no 2631 0.256059626825444 833 717301
SGTC_390 dec-rvkr-cmk 16.7 µM -0.656515189512434 0.229419681038254 no 2632 0.255746348797119 806 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_907 3448-6986 75.5 µM -0.656790029554948 0.229326681761374 no 2633 0.255657968027737 827 590582
SGTC_411 enrofloxacin 100 µM -0.657270394390385 0.229164188585714 no 2634 0.25550353461767 803 71188 A bacterial gyrase inhibitor.
SGTC_2003 4023581 200 µM -0.658535483507878 0.228736555574612 no 2635 0.255097052011945 817 16641307
SGTC_1264 0783-0040 158 µM -0.658904941925713 0.228611753602452 no 2636 0.254978406103031 820 2855798
SGTC_3240 9133527 49.47 µM -0.659170006574886 0.228522239105432 no 2637 0.254893302444614 835 17617455
SGTC_77 0828-0286 12.516 µM -0.659280534449873 0.228484918756845 no 2638 0.254857819922538 805 745345
SGTC_1204 4049-0315 18.3 µM -0.659996021924534 0.228243413293519 no 2639 0.254628191093438 821 588402
SGTC_2159 5658611 73.75 µM -0.660435172701217 0.228095253545356 no 2640 0.254487303557625 817 793844
SGTC_2868 9035608 32.47 µM -0.660648160352387 0.228023415708742 no 2641 0.254418987966996 813 6462614
SGTC_1637 st007924 17.4 µM -0.661076306853857 0.227879046228242 no 2642 0.254281689458892 815 683336
SGTC_501 nsc-95397 161 µM -0.661202098602374 0.227836639474138 no 2643 0.254241357801904 826 262093
SGTC_2591 skatole 100 µM -0.661386793133344 0.227774383536456 no 2644 0.254182146669573 833 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_2673 kobusone 100 µM -0.661686852667823 0.227673261337315 no 2645 0.254085966145579 839 6710676 An epoxy ketone and protein crosslinker.
SGTC_3288 9119690 36.221 µM -0.663971433312232 0.226904170659132 no 2646 0.253354297406323 835 17595618 YKL019W RAM2
SGTC_858 0438-0351 2.77 µM -0.665337318010508 0.226445054431431 no 2647 0.252917383426969 820 2799119
SGTC_2890 9046729 58.44 µM -0.665632420619162 0.226345930244448 no 2648 0.252823039252041 831 903329
SGTC_2016 5121758 140 µM -0.666328205873005 0.226112314856013 no 2649 0.252600670369456 831 2795203
SGTC_518 1021-0119 62.6 µM -0.666734903481136 0.22597582605455 no 2650 0.252470739928458 830 1097762
SGTC_2380 9035439 200 µM -0.667108697770842 0.225850420783448 no 2651 0.252351352400677 825 6462575
SGTC_1843 st055809 45.5 µM -0.667608711915292 0.225682731219215 no 2652 0.252191697593812 824 16413835
SGTC_1916 st067606 49.2 µM -0.668181050025311 0.225490872883053 no 2653 0.252009015108784 805 19590279
SGTC_1023 4482-3888 16 µM -0.66885687139302 0.225264443958534 no 2654 0.25179339212266 827 3303168
SGTC_3081 9117243 49.47 µM -0.669711598634254 0.224978258456603 no 2655 0.251520828201867 827 45595589
SGTC_152 4469-0003 551.229 µM -0.670707250206969 0.224645147702593 no 2656 0.251203521608637 819 697280
SGTC_2702 st077768 96.8 µM -0.672552656245358 0.224028478763226 no 2657 0.25061596499845 804 6484119
SGTC_690 glyoxal 20.3 µM -0.672949031452499 0.22389614986699 no 2658 0.250489858614257 823 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_38 0929-0051 58.268 µM -0.673017632408037 0.223873252115205 no 2659 0.250468036701268 828 1379719
SGTC_1891 st059073 26.2 µM -0.673207573179732 0.223809860282859 no 2660 0.250407621939598 827 688754
SGTC_1432 4049-0298 68.4 µM -0.674216329670469 0.223473363616829 no 2661 0.250086894648729 828 741646
SGTC_677 0929-0063 136 µM -0.675437324449345 0.223066454685248 no 2662 0.249698979352267 848 1539583
SGTC_463 ikarugamyin 104 µM -0.676773405934901 0.222621675768047 no 2663 0.249274866942099 842 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_814 3342-0569 96 µM -0.677248630858452 0.222463596295704 no 2664 0.249124108668441 830 4346283
SGTC_95 0471-0001 561.058 µM -0.677265689104288 0.222457923207751 no 2665 0.249118698087067 816 4015405
SGTC_2900 5328528 85.29 µM -0.677342637928514 0.222432333240429 no 2666 0.249094292024137 820 795359
SGTC_521 r062-0005 13.8 µM -0.677791936202783 0.22228294891183 no 2667 0.248951812297107 815 2832033
SGTC_1356 1502-0781 85.8 µM -0.678655022316785 0.221996147543916 no 2668 0.248678235499877 821 567702
SGTC_1175 0741-0056 27.6 µM -0.67898624647614 0.221886138704202 no 2669 0.248573288222667 830 765927
SGTC_1012 4112-3522 18 µM -0.679277052636416 0.221789579488159 no 2670 0.248481166709992 815 3112398
SGTC_998 3996-0085 177 µM -0.680003237375373 0.221548562099677 no 2671 0.248251205524616 836 715391
SGTC_2813 7971799 71.43 µM -0.680525980050353 0.221375158908319 no 2672 0.248085738683743 823 2234054
SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.681813409046796 0.220948426542547 no 2673 0.247678472153727 832 94937 An inhibitor of serotonin biosynthesis.
SGTC_582 0987-0078 156 µM -0.681951750714531 0.220902599723532 no 2674 0.247634730272727 841 1625765
SGTC_921 1561-0023 372 µM -0.684623563283152 0.220018607751336 no 2675 0.246790746993681 827 24050882
SGTC_1838 st055369 84.5 µM -0.68529115175587 0.21979804773691 no 2676 0.246580107083029 814 676036
SGTC_3322 9139058 2.11 µM -0.686281246928791 0.219471170741803 no 2677 0.246267886116769 812 4908926 YPR165W RHO1
SGTC_47 0149-0135 24.25 µM -0.687134147536782 0.219189812166953 no 2678 0.245999098714704 824 5239155
SGTC_1898 st060199 18.6 µM -0.687585883217147 0.219040875665848 no 2679 0.245856800238348 820 688866
SGTC_3307 9126885 69.2785 µM -0.688529001234449 0.218730118889067 no 2680 0.245559856896895 817 24824909
SGTC_2267 7931562 200 µM -0.688799223218954 0.218641127706679 no 2681 0.245474812271659 819 934880
SGTC_1307 1187-1599 12.2 µM -0.688915401010488 0.218602873722261 no 2682 0.24543825350645 839 1538471
SGTC_15 0266-0086 27.098 µM -0.690008384347639 0.218243174631795 no 2683 0.245094457377614 850 1712902 YIL048W NEO1
SGTC_259 usnic acid 108.925 µM -0.691247217983248 0.217835889067383 no 2684 0.244705097655052 860 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_213 1246-0773 967 nM -0.693236039062971 0.217182951295603 no 2685 0.244080717463136 833 6251622
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.693385904364959 0.217133795776955 no 2686 0.244033702857179 848 4620898
SGTC_2653 dihydrofissinolide 100 µM -0.694032631533447 0.216921744294636 no 2687 0.24383087255044 836 6857746
SGTC_618 k072-0232 33.2 µM -0.694264626103839 0.216845706171913 no 2688 0.243758135253805 834 5872756 YGL099W LSG1
SGTC_2506 ethyl hematommate 54.16 µM -0.695947836954193 0.216294481695965 no 2689 0.243230748826745 835 3940691 An allergen.
SGTC_3010 9080089 71.4286 µM -0.696022457298315 0.216270063526046 no 2690 0.243207382943357 817 17027233
SGTC_461 N-acetylfarnesylcysteine 136 µM -0.697412487879549 0.215815492783645 no 2691 0.242772344312449 871 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_1112 tnp00069 1.16933 µM -0.697610035812146 0.21575093521189 no 2692 0.242710551828547 827 145826
SGTC_604 1000-0114 314 µM -0.698991349039145 0.215299842582183 no 2693 0.242278718613698 846 1572745
SGTC_1010 4112-3296 15.2 µM -0.69960486764017 0.21509966272662 no 2694 0.242087050918219 832 704384
SGTC_2192 5915882 198.485 µM -0.700361024140697 0.214853091464539 no 2695 0.241850935260889 827 2876149
SGTC_681 1642-0006 26.6 µM -0.701057215890381 0.214626219051444 no 2696 0.24163365458699 856 4446530
SGTC_2280 7785178 200 µM -0.703535872220011 0.213819614832697 no 2697 0.240860929756655 834 2954328
SGTC_1438 4092-1045 4 µM -0.706037274748151 0.213007401024008 no 2698 0.240082478682258 847 1351342
SGTC_605 1315-0399 119 µM -0.706783043437088 0.212765596222842 no 2699 0.239850656810545 853 24020461
SGTC_2892 9047358 58.44 µM -0.707065180302278 0.212674159187511 no 2700 0.239762986535232 840 6466771
SGTC_281 1672-3440 14.9 µM -0.707770017893874 0.21244583041305 no 2701 0.239544044057526 825 6833000
SGTC_2146 5545642 200 µM -0.708090734214511 0.212341983319114 no 2702 0.239444456647418 838 825326
SGTC_2138 5575593 77.673 µM -0.709155476835763 0.211997435269347 no 2703 0.239113999672447 841 762213
SGTC_3213 9129884 49.47 µM -0.709328767815779 0.211941389696401 no 2704 0.239060240117422 838 17190742
SGTC_1471 k673-0312 37 µM -0.709764576352906 0.211800479303038 no 2705 0.238925069713356 828 24099884
SGTC_530 4358-1714 28 µM -0.710388250932173 0.211598921387538 no 2706 0.238731703488899 836 1564641
SGTC_176 1486-1328 72.834 µM -0.711581427103078 0.21121362612926 no 2707 0.238362005732026 838 22310231
SGTC_1899 st063254 59.6 µM -0.7117203390772 0.211168796009518 no 2708 0.238318985159611 827 3093813
SGTC_2626 ethyl orsellinate 100 µM -0.711767101530549 0.211153705934486 no 2709 0.238304503941501 857 75653 A natural product.
SGTC_3210 9128157 49.47 µM -0.713590425295645 0.210565818770261 no 2710 0.237740239929817 850 17590849
SGTC_619 1652-1634 108 µM -0.716278225711546 0.209700955591734 no 2711 0.236909784531 845 5400454
SGTC_1661 st013063 9.66 µM -0.716798726124487 0.209533714049806 no 2712 0.236749148930472 861 721395
SGTC_801 0866-0028 10.1 µM -0.717451970198112 0.209323931820431 no 2713 0.236547631091592 829 6849771
SGTC_1936 st074407 74.3 µM -0.719001556971439 0.208826793547285 no 2714 0.236069980181099 852 809813
SGTC_300 r073-0011 5.04 µM -0.721656835617615 0.207976546552171 no 2715 0.235252743188362 838 2735780
SGTC_2636 apigenin dimethyl ether 100 µM -0.722546239826936 0.207692207939401 no 2716 0.234979353571303 848 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_2378 9074213 121.43 µM -0.722683782785577 0.207648256573554 no 2717 0.234937090590949 839 657714
SGTC_2470 5664817 21.68 µM -0.723002528421849 0.207546423658975 no 2718 0.234839165407078 847 2859561
SGTC_3194 9111903 49.47 µM -0.72446606627288 0.207079231316683 no 2719 0.234389826356358 853 17087251
SGTC_2877 9040724 71.43 µM -0.728707672322696 0.205728739910383 no 2720 0.233090249317956 844 6463895
SGTC_2587 piperic acid 92.2 µM -0.729374398159111 0.205516936433229 no 2721 0.232886337025155 832 5370536
SGTC_260 nsc-65238 3.989 µM -0.730264176822793 0.20523447597665 no 2722 0.232614360408482 853 3246252
SGTC_1719 st032227 49.2 µM -0.731225911302899 0.204929432656004 no 2723 0.232320587898136 846 3125804
SGTC_1391 3442-0225 151 µM -0.731565063208674 0.204821924645228 no 2724 0.232217039419898 841 5227075
SGTC_1635 st007035 42.4 µM -0.733066525726897 0.204346378024702 no 2725 0.231758927676283 835 3716403
SGTC_1216 1165-0504 9.65 µM -0.733256513866691 0.204286251433765 no 2726 0.231700996238326 862 6304004
SGTC_737 1950-0117 57.9 µM -0.736618039106918 0.203224154093055 no 2727 0.230677330893395 851 5393513
SGTC_2776 terbinafine 19.92 µM -0.737218285727077 0.203034849386441 no 2728 0.230494807586251 834 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_952 1185-0122 232 µM -0.73859790825534 0.202600145826093 no 2729 0.230075597387681 845 678600
SGTC_1670 st016595 4.04 µM -0.738620256610139 0.202593108692363 no 2730 0.230068810160528 865 597879
SGTC_855 0428-0020 25 µM -0.73960224301255 0.20228404140407 no 2731 0.229770690130663 839 6812414
SGTC_211 3455-0679 143.504 µM -0.741567347407685 0.201666398194153 no 2732 0.229174756606097 828 748649
SGTC_1150 3909-7983 10.9 µM -0.742065837961181 0.201509899652633 no 2733 0.22902372333168 853 23965914
SGTC_2459 5811157 9.22 µM -0.74327815694365 0.20112960216566 no 2734 0.228656646597818 851 2870684 YBR192W RIM2
SGTC_2750 bromebric acid 70.15 µM -0.743886679010922 0.20093887465231 no 2735 0.228472517481519 855 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_2526 patulin 37.61 µM -0.743984270082425 0.200908297032549 no 2736 0.228442995725603 854 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_3280 9140961 49.47 µM -0.744522085092131 0.200739836804923 no 2737 0.228280342624614 876 4901226
SGTC_316 k060-0003 58.6 µM -0.744693327063457 0.200686216345504 no 2738 0.228228567037779 863 6152314
SGTC_838 0109-0203 71.4 µM -0.746294126046116 0.200185379197432 no 2739 0.227744879498158 833 759422
SGTC_1140 3229-1848 2.98 µM -0.74652357407826 0.200113654084916 no 2740 0.227675598203979 855 2849525
SGTC_471 1-acyl-paf 4 µM -0.748688216709688 0.199437750608405 no 2741 0.22702257370003 846 16759367
SGTC_1999 st074831 12.5 µM -0.749293104852252 0.199249121975411 no 2742 0.226840281388177 870 17112523
SGTC_2597 laccaic acid a 100 µM -0.749385294597227 0.199220382915984 no 2743 0.226812505849017 868 5491415 A textile dye.
SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.749389440989112 0.199219090386173 no 2744 0.2268112566416 877 229346 A bile salt which induces apoptosis.
SGTC_269 exalamide 29 µM -0.749666367144232 0.199132777294546 no 2745 0.226727834287474 851 3316 A derivative of salicylamide.
SGTC_2859 9028643 45.46 µM -0.749945558150642 0.199045781096678 no 2746 0.226643747190287 821 17151580
SGTC_2661 dactinomycin 12.96 µM -0.750970154627384 0.198726712087436 no 2747 0.226335308810071 849 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_1986 st071812 45 µM -0.753976234307448 0.19779237179158 no 2748 0.225431746180707 854 11838594
SGTC_167 3672-0051 66.205 µM -0.755967422785365 0.197174940738053 no 2749 0.224834363968889 841 3237971
SGTC_1505 k297-0037 20.6 µM -0.756492085893613 0.197012446650396 no 2750 0.224677107803991 852 4089396
SGTC_2123 5259487 200 µM -0.756841392692362 0.196904307350698 no 2751 0.224572445417501 837 2173474
SGTC_303 1348-1668 34.2 µM -0.757485250853832 0.196705074270656 no 2752 0.224379599451392 859 5380509
SGTC_1570 verbenone 133 µM -0.757797110185102 0.196608617585169 no 2753 0.224286226321933 861 29025 A natural terpanoid with antifungal properties.
SGTC_2498 4'-Methoxychalcone 54.63 µM -0.757891148922916 0.196579537451356 no 2754 0.224258074715888 855 641818 YHR062C RPP1
SGTC_2712 st079126 47.7 µM -0.759382729638465 0.196118636006753 no 2755 0.223811820783939 858 3152970
SGTC_2940 9060638 45.86 µM -0.759499440796503 0.196082599691829 no 2756 0.223776924224765 845 4027022
SGTC_962 1254-0300 21.5 µM -0.761528380861643 0.195456776078381 no 2757 0.223170766944691 826 7340576
SGTC_520 3584-0023 682 µM -0.761910929135142 0.195338915695454 no 2758 0.223056583319667 844 1340790
SGTC_2193 5925765 200 µM -0.764519858972233 0.194536274978838 no 2759 0.22227875341273 858 877370
SGTC_256 clotrimazole 625 nM -0.764807069540721 0.194448037078945 no 2760 0.2221932187254 821 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_2059 5238311 157 µM -0.765137368930898 0.194346591395916 no 2761 0.222094874905706 865 703021
SGTC_2101 5377231 179.231 µM -0.765354637049247 0.194279878865054 no 2762 0.22203019873025 868 2844213
SGTC_17 0960-0276 49.807 µM -0.765422777099934 0.194258959223978 no 2763 0.222009917077208 857 6821114
SGTC_3204 9114183 49.47 µM -0.766557983184969 0.193910642028694 no 2764 0.22167218250437 856 17027248
SGTC_3296 9122258 64.045 µM -0.767010703580648 0.193771839298671 no 2765 0.221537575822893 859 4730474
SGTC_764 1951-2361 146 µM -0.767330910544615 0.193673701374436 no 2766 0.22144239737861 852 5438930
SGTC_2251 lansoprazole 556 µM -0.771051906804435 0.192535503695004 no 2767 0.220338082676119 870 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_1440 4100-1550 40 µM -0.771498940020285 0.192399038511208 no 2768 0.220205625224462 864 742806
SGTC_2903 5923464 63.88 µM -0.772751467746574 0.192016996302233 no 2769 0.219834740334569 863 2876576
SGTC_166 k072-0058 166.424 µM -0.77583660695194 0.191077958470953 no 2770 0.218922733268019 870 5846229
SGTC_3252 9135871 49.47 µM -0.775847328109076 0.191074700141606 no 2771 0.218919567754857 870 17682838
SGTC_3029 9088683 49.47 µM -0.776614609359228 0.190841599709318 no 2772 0.218693089797566 840 25236615
SGTC_1475 4092-1048 11.7 µM -0.778616680567172 0.190234191531202 no 2773 0.218102775039571 883 2881759
SGTC_931 2812-0076 566 µM -0.778884745976395 0.190152953449724 no 2774 0.218023805188793 870 3450959
SGTC_2981 9013952 38.96 µM -0.780860956958552 0.189554714445449 no 2775 0.217442138714194 838 2996344
SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.780873351167011 0.189550966125885 no 2776 0.217438493504057 873 5106787 A p450 inhibitor.
SGTC_1058 3448-5425 97.3 µM -0.781607279729489 0.189329089028158 no 2777 0.217222703670687 858 7279705
SGTC_1017 4239-0030 168 µM -0.783440679944965 0.188775524829682 no 2778 0.216684187736532 851 1149593
SGTC_1472 k841-0093 193 µM -0.78458311459913 0.188431090973134 no 2779 0.216349016671304 874 X1472
SGTC_700 3453-2283 142 µM -0.786224486234692 0.187936911051904 no 2780 0.215867991599375 870 565664
SGTC_2769 toremifene 3.73 µM -0.786282624771171 0.187919421538288 no 2781 0.215850964726345 865 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_1985 st071382 65.5 µM -0.787096401596308 0.187674722776164 no 2782 0.215612717853002 889 6123237
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.788052567613707 0.187387459917472 no 2783 0.215332979077164 874 688798
SGTC_1317 1273-0028 910 nM -0.790779691778792 0.186569638791272 no 2784 0.214536281344341 864 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_42 0133-0086 60.653 µM -0.791366739193409 0.186393882138801 no 2785 0.2143650066553 890 162923 Model of phenazepam hydroxylation.
SGTC_583 1488-1091 88.9 µM -0.79227375533405 0.186122531495129 no 2786 0.214100535538098 894 4303273
SGTC_2352 9027995 87.8 µM -0.7924222225304 0.186078138120207 no 2787 0.214057263016323 869 2997347
SGTC_3184 9108758 49.47 µM -0.792850693889141 0.185950057135744 no 2788 0.213932408513547 887 902885
SGTC_3000 9075062 71.4286 µM -0.794274904910003 0.185524717214167 no 2789 0.213517705038447 841 17057871
SGTC_1109 tnp00067 928.257 nM -0.795936049540194 0.185029380709222 no 2790 0.213034603312338 871 676295
SGTC_2675 theaflavin digallate 100 µM -0.796387959804239 0.18489476794344 no 2791 0.212903287116433 872 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_2473 5854593 8.94 µM -0.796864499240564 0.184752884708681 no 2792 0.212764865354432 875 2872951
SGTC_735 3076-0345 636 µM -0.79805008294234 0.184400186803522 no 2793 0.212420713537761 866 2888990
SGTC_976 1348-1067 47.6 µM -0.798062753438752 0.18439641973602 no 2794 0.212417037297296 877 5310671 YGL099W LSG1
SGTC_2083 5306046 65.942 µM -0.799591559219093 0.183942241656311 no 2795 0.21197373975723 867 539837
SGTC_3145 9085516 49.47 µM -0.80074419007466 0.183600278739701 no 2796 0.211639877186935 881 25236195
SGTC_2246 7293507 91.5585 µM -0.803178670981878 0.182879319187574 no 2797 0.21093573581835 848 887656
SGTC_805 3852-0218 479 µM -0.803619918362477 0.182748835345891 no 2798 0.210808258057779 854 6615355
SGTC_3263 9137018 49.47 µM -0.803760846121047 0.182707173023781 no 2799 0.210767553105619 877 43844957
SGTC_2990 9074105 71.4286 µM -0.805884113888211 0.182080191537883 no 2800 0.210154835980863 891 6502001
SGTC_353 1988-1175 58.3 µM -0.809221184573984 0.181097507256567 no 2801 0.209193965787112 884 2788357
SGTC_1132 3456-3614 2.5 µM -0.809316000374507 0.181069634992059 no 2802 0.20916670253533 892 3125502
SGTC_2071 5230951 39.92 µM -0.814841671577882 0.179449940557693 no 2803 0.207581472165593 882 1799272
SGTC_236 1509-0011 5.31 µM -0.815219776137601 0.179339443826183 no 2804 0.20747325990277 889 3107280
SGTC_2020 4017018 200 µM -0.815607569507817 0.179226160101117 no 2805 0.207362309377623 897 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_474 dl-dihydrosphingosine 5 µM -0.816816247968721 0.178873365016385 no 2806 0.207016722741641 841 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_2095 5432005 200 µM -0.817433758236419 0.178693291860592 no 2807 0.206840295154261 889 783734
SGTC_1165 k072-0275 30.3 µM -0.821164409354618 0.177607819901414 no 2808 0.205776313059295 880 6153523 YGL055W OLE1
SGTC_1840 st055363 71 µM -0.821588714066566 0.177484628089072 no 2809 0.205655507344334 901 676033
SGTC_3108 9121785 49.47 µM -0.823668212704437 0.176881650670706 no 2810 0.20506405286744 855 17140271
SGTC_2406 ethylparaben 405.7 µM -0.826825409920721 0.175968658943582 no 2811 0.20416801279054 907 8434 A possible steroid mimic.
SGTC_1013 4112-3890 241 µM -0.827090218899449 0.175892217907595 no 2812 0.204092963839322 878 705171
SGTC_1992 st073643 23.3 µM -0.827574757381671 0.175752403147659 no 2813 0.203955684366497 889 3161292
SGTC_1534 6-azauridine 81.6 µM -0.828648673647343 0.175442773018889 no 2814 0.203651618527953 878 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_769 0302-0231 76 µM -0.835330114809752 0.173524163835374 no 2815 0.201765933008891 888 571869 YER009W NTF2
SGTC_263 alizarin 107.927 µM -0.835341107516844 0.173521018267777 no 2816 0.201762839206949 905 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_2939 9044578 71.43 µM -0.83643819169983 0.173207269729239 no 2817 0.201454217309397 892 2653634
SGTC_3163 9099914 49.47 µM -0.836536010563735 0.173179312650465 no 2818 0.201426713526024 908 16268368
SGTC_2108 5365811 200 µM -0.838145873194879 0.172719619437726 no 2819 0.200974390926908 867 780283
SGTC_3009 9080819 71.4286 µM -0.838398475588781 0.172647559969368 no 2820 0.200903472660701 897 17027216
SGTC_2943 9068529 45.32 µM -0.839709794107041 0.172273790375841 no 2821 0.200535560602443 894 3270634
SGTC_2528 xanthyletin 44.79 µM -0.840845994669029 0.171950353050837 no 2822 0.200217108169791 898 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_1003 4049-0218 100 µM -0.840898405305921 0.17193544290069 no 2823 0.200202425938554 886 295161
SGTC_2131 toluylene red 5.2905 µM -0.841874627131047 0.171657871280433 no 2824 0.199929067017508 861 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_2063 5246145 200 µM -0.843254470343059 0.171266025543977 no 2825 0.19954307021275 897 711240
SGTC_509 pifithrin 175 µM -0.845169893466452 0.170723035380591 no 2826 0.199007994557699 906 4817 A p53 inhibitor.
SGTC_926 2268-1401 59.4 µM -0.848535890026013 0.169771504854883 no 2827 0.19806979678134 888 2931578
SGTC_3150 9097574 49.47 µM -0.848579560665789 0.169759182032487 no 2828 0.19805764212447 870 17217476
SGTC_889 0919-1524 82.7 µM -0.849143505994511 0.169600101524671 no 2829 0.197900722171189 890 3905452
SGTC_3275 9138069 49.47 µM -0.8498052640483 0.169413551510805 no 2830 0.197716681254208 895 17617007
SGTC_3245 9134821 49.47 µM -0.850379159406841 0.169251876708832 no 2831 0.197557159523396 910 17014901
SGTC_2250 alverine citrate 130 µM -0.850394876632519 0.169247450328069 no 2832 0.197552791809596 867 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_2168 5727979 200 µM -0.851199108036864 0.16902105697933 no 2833 0.19732937910766 884 695210
SGTC_1818 st052136 56.3 µM -0.852382914897833 0.168688166138282 no 2834 0.19700079982211 869 674169
SGTC_2787 5284540 71.43 µM -0.852463204225313 0.168665603753377 no 2835 0.196978526589313 891 736958
SGTC_554 4483-2211 187 µM -0.853410907991879 0.168399432779252 no 2836 0.19671573727716 898 747107
SGTC_106 0092-0003 11.579 µM -0.85367903054345 0.168324177241012 no 2837 0.196641427976823 889 1072148
SGTC_1334 1486-0610 236 µM -0.859542801724425 0.166683769064783 no 2838 0.195020558211378 860 3742339
SGTC_2357 9067248 200 µM -0.860638371133883 0.166378427761345 no 2839 0.194718622819268 921 9150235
SGTC_2040 5100729 123 µM -0.860836743726115 0.166323178856861 no 2840 0.194663982397389 882 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_1156 4092-0367 4.88 µM -0.862465877502793 0.16586989579645 no 2841 0.194215601237072 889 1357585
SGTC_1390 3413-2614 145 µM -0.863217824393647 0.165660946963543 no 2842 0.19400885768869 920 3421432
SGTC_614 0462-0418 107 µM -0.864159668601974 0.165399470227787 no 2843 0.193750092198321 863 5188303
SGTC_1203 3992-3522 103 µM -0.864233554497586 0.165378969173795 no 2844 0.193729801440005 904 5322312
SGTC_1149 3909-7961 23.3 µM -0.866792147352141 0.164670053005897 no 2845 0.193027952727908 892 735261
SGTC_2389 9091542 195.52 µM -0.870307283839201 0.163699320310932 no 2846 0.192066249729544 877 3626624 YOL127W RPL25
SGTC_1940 st075990 51.1 µM -0.870375185824991 0.163680605288726 no 2847 0.192047701398503 926 1084979
SGTC_1219 1469-0211 33.1 µM -0.871055776462101 0.16349309886949 no 2848 0.191861849568618 904 6822282
SGTC_1293 1000-1278 195 µM -0.873170841914384 0.162911277608977 no 2849 0.191284982620244 904 678847
SGTC_3255 9139072 49.47 µM -0.876503898898781 0.16199714180444 no 2850 0.190378078874212 889 17646060
SGTC_2446 5162541 200 µM -0.876844022433254 0.161904046575865 no 2851 0.190285682130452 893 1549321
SGTC_958 1222-0007 33 µM -0.87802660619959 0.161580632844578 no 2852 0.189964640102044 891 7312461
SGTC_755 1995-0008 37.3 µM -0.87898996301131 0.161317484935836 no 2853 0.189703358981188 879 689533
SGTC_87 0100-0052 35.5 µM -0.879827644814799 0.161088893404046 no 2854 0.189476343127086 914 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_1137 ixabepilone 100 µM -0.88028471787454 0.160964253798016 no 2855 0.189352544623859 886 154225 A novel microtubule stabilizer.
SGTC_2197 6588183 93.1375 µM -0.880796832820194 0.16082467956951 no 2856 0.189213897151865 877 884136
SGTC_2217 6934799 96.0675 µM -0.881309331380918 0.16068507991789 no 2857 0.189075208417599 896 675606
SGTC_1748 st037455 53.6035 µM -0.885102121928885 0.159654421143064 no 2858 0.188050777559826 891 580690
SGTC_818 4072-2707 53.5 µM -0.886339692382133 0.159319059989875 no 2859 0.187717253130142 904 882871
SGTC_473 2-arachidonoylglycerol 10 µM -0.888829488965264 0.158645764799954 no 2860 0.18704736247232 878 5282280 An endocannabinoid.
SGTC_1718 roemerine 11.9335 µM -0.889099531563419 0.158572851717614 no 2861 0.186974795330062 860 235224 An aporphine alkaloid with mutagenic activity.
SGTC_3159 9100096 49.47 µM -0.89015983729939 0.158286775538103 no 2862 0.186690033386638 898 25236875
SGTC_2355 9061122 103.12 µM -0.890458949450329 0.158206134752118 no 2863 0.186609750647121 920 5302957
SGTC_2969 9091408 28.7 µM -0.891049326910379 0.158047047831077 no 2864 0.186451354034911 896 4286311
SGTC_980 1473-0395 201 µM -0.89156615248353 0.157907866911921 no 2865 0.186312759569205 902 768876
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.891865205211588 0.157827368901932 no 2866 0.186232593291742 899 676296 Flavone; oxidizing agent.
SGTC_364 0083-0097 67.7 µM -0.894239896523293 0.157189114298298 no 2867 0.185596775059632 930 5207356
SGTC_177 1327-0068 8.361 µM -0.894309054811539 0.15717055183809 no 2868 0.185578278292676 887 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_1474 0330-0125 5.35 µM -0.894434272309413 0.157136946449353 no 2869 0.185544791090586 920 X1474
SGTC_552 k242-0005 476 µM -0.896366420852827 0.156619002912602 no 2870 0.185028547647439 917 4088318
SGTC_2428 5615643 7.78 µM -0.896466732581053 0.156592143461375 no 2871 0.185001770126977 897 2253075
SGTC_1944 st076371 56.9 µM -0.897279842780413 0.156374537132634 no 2872 0.184784804864221 892 24208455
SGTC_1602 st001878 87.6 µM -0.89792323188455 0.156202493143921 no 2873 0.184613239061325 905 595405 YLR310C CDC25
SGTC_1069 diphenylcyclopropenone 8.49 µM -0.899300617072491 0.155834596030068 no 2874 0.184246279393314 918 65057 A dermal irritant. YDR527W RBA50
SGTC_3120 9124077 49.47 µM -0.899935371537565 0.155665246704049 no 2875 0.184077322527462 930 18774327 YGL155W CDC43
SGTC_1326 1431-2094 10.8 µM -0.902392013371716 0.155010971214444 no 2876 0.18342433109593 912 616278
SGTC_1744 st037937 38.9 µM -0.903166275255647 0.154805139566063 no 2877 0.183218826882268 915 1016152
SGTC_2089 5281248 129.67 µM -0.906831097120602 0.1538333254426 no 2878 0.182248061258246 900 2737878
SGTC_1630 st005209 31.3 µM -0.907151992803588 0.153748425048007 no 2879 0.182163213316832 875 3367314
SGTC_1684 st024538 14.6195 µM -0.907482477438917 0.153661020101933 no 2880 0.182075855776815 913 6732859
SGTC_1190 1486-1332 13 µM -0.908018566677723 0.15351930784429 no 2881 0.181934206149243 894 4150046
SGTC_3131 9127911 49.47 µM -0.909343257087424 0.153169504480124 no 2882 0.18158448189033 891 45595681
SGTC_836 0330-0104 1.35 µM -0.909465342288447 0.153137292749581 no 2883 0.181552272032593 877 46494820
SGTC_1920 st075728 45.7 µM -0.910766789106312 0.152794189845867 no 2884 0.181209132320002 868 3400306
SGTC_1240 0356-0016 42.1 µM -0.910926904305181 0.152752013617652 no 2885 0.181166944395678 862 4305613
SGTC_2907 7721985 69.9 µM -0.910927808026689 0.152751775588685 no 2886 0.181166706296241 900 3267881
SGTC_3248 9135562 49.47 µM -0.911520472094386 0.152595728251593 no 2887 0.181010601978102 902 17650701
SGTC_262 fenpropimorph 62.5 µM -0.911682310277111 0.152553134951915 no 2888 0.180967989382441 934 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_2162 5663267 200 µM -0.912028534112724 0.1524620406998 no 2889 0.180876848469738 918 6456493
SGTC_1849 st056239 19.2 µM -0.912746110346138 0.152273355632365 no 2890 0.180688043355594 878 5393181
SGTC_1675 st018485 24.5 µM -0.913427353977848 0.152094367649138 no 2891 0.180508912285806 914 3323024
SGTC_2322 7413319 38.22 µM -0.913891865862131 0.151972403285318 no 2892 0.180386834104857 879 1840400
SGTC_743 1275-0778 158 µM -0.914263194084117 0.151874952387071 no 2893 0.180289282748878 906 2849257 YMR203W TOM40
SGTC_1852 st056254 31.4 µM -0.914306709683453 0.151863534927809 no 2894 0.180277852966256 888 442583
SGTC_60 0986-0278 202 µM -0.914729960383572 0.151752513749626 no 2895 0.180166705899714 910 3110598
SGTC_472 calcifediol 10 µM -0.915955681254263 0.151431304206119 no 2896 0.179845070169481 923 5283731 A vitamin D metabolite.
SGTC_173 1273-0061 2.693 µM -0.91768644246563 0.15097851539816 no 2897 0.179391523753697 887 2847414 YPL266W DIM1
SGTC_2098 5376439 882.5 nM -0.918590186827864 0.150742443001803 no 2898 0.17915498335454 901 2844116
SGTC_1743 st037606 46.3785 µM -0.918906654150615 0.150659834837261 no 2899 0.179072199576346 891 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_1194 1488-0194 225 µM -0.922086686458246 0.149831417636205 no 2900 0.178241680434146 907 1391452
SGTC_2481 5478948 45.16 µM -0.922637571549125 0.149688218153706 no 2901 0.178098054569358 905 77792
SGTC_2141 5621638 7.665 µM -0.923803081361621 0.149385551475555 no 2902 0.177794425299421 913 2856238
SGTC_454 lyso-paf C-16 6.67 µM -0.926271810262458 0.148745806938115 no 2903 0.177152370938659 904 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_1349 flufenamic acid 69 µM -0.926852820753891 0.148595510907226 no 2904 0.177001477872203 912 3371 A non-steroidal anti-inflammatory.
SGTC_3208 9114115 49.47 µM -0.927868968903276 0.148332897432842 no 2905 0.176737771362262 909 650895
SGTC_969 1313-0238 134 µM -0.92794488904927 0.148313289091004 no 2906 0.176718078861139 916 5212874
SGTC_2308 7584454 197.62 µM -0.930155560401028 0.147743086320033 no 2907 0.176145273596679 916 893577
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.930620893336212 0.14762324936517 no 2908 0.176024851447617 896 688664
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.930887251217249 0.147554683662862 no 2909 0.175955944933585 922 6708784 An antioxidant flavonoid
SGTC_2931 9014674 55.67 µM -0.931870483196518 0.147301765367426 no 2910 0.175701731743063 923 2996810
SGTC_1923 st058458 19.1 µM -0.932650311208195 0.147101375719737 no 2911 0.175500273901416 938 3534982
SGTC_636 0kpi-0074 126 µM -0.938215862645397 0.145676524287907 no 2912 0.174066744028153 920 616434
SGTC_1096 rimcazole 32.2 µM -0.938476787137611 0.145609952794682 no 2913 0.173999720373115 900 18528119 A dopamine reuptake inhibitor.
SGTC_1777 st045864 34.765 µM -0.939020134765233 0.145471390366077 no 2914 0.173860203375274 938 4691462
SGTC_2243 6634756 200 µM -0.941470155978304 0.14484769707852 no 2915 0.173231988080998 908 885676
SGTC_3043 9092303 49.47 µM -0.942604763956056 0.14455947479939 no 2916 0.172941551091551 904 25236084
SGTC_2383 9036125 200 µM -0.943057071948686 0.144444683662396 no 2917 0.172825855822527 919 79580
SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.94309019138446 0.144436280702924 no 2918 0.172817386184067 890 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_1044 1222-0021 1.78 µM -0.943119921025016 0.144428738072244 no 2919 0.172809783643779 893 4306703
SGTC_3019 9081971 49.47 µM -0.943186150005251 0.144411936242221 no 2920 0.172792848164658 921 16451803
SGTC_2057 5236571 38.335 µM -0.94321462586671 0.144404712519871 no 2921 0.172785566898696 923 54684039 YBR257W POP4
SGTC_1290 0986-0249 10.2 µM -0.947398084104301 0.143346103210087 no 2922 0.171717983518613 915 53329
SGTC_410 α-linolenic acid 100 µM -0.947451248948238 0.143332683842944 no 2923 0.171704443467167 911 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_942 3253-1115 227 µM -0.948283340087231 0.143122765806529 no 2924 0.171492614913846 919 46497897
SGTC_399 oxolinic acid 75 µM -0.949832721661635 0.142732445038364 no 2925 0.171098628262094 893 4628 A DNA gyrase inhibitor.
SGTC_3071 9117417 49.47 µM -0.951093477178955 0.142415366560589 no 2926 0.170778462827316 919 45595590 YGL055W OLE1
SGTC_2060 5238662 140 µM -0.953543738730453 0.141800492543392 no 2927 0.170157323055787 928 790130
SGTC_2118 5526350 200 µM -0.955106153596757 0.141409356777414 no 2928 0.169762008694064 924 743594
SGTC_1665 st014639 11.4 µM -0.959355482591253 0.140349278844 no 2929 0.168689846800798 904 981133 YIL048W NEO1
SGTC_3117 9124945 49.47 µM -0.959478423077163 0.140318689480413 no 2930 0.168658892207266 901 17592065
SGTC_711 k292-0785 179 µM -0.960687060822456 0.140018204058094 no 2931 0.168354769518831 897 4146315
SGTC_43 0570-0105 72.5 µM -0.963558335904721 0.139306116314334 no 2932 0.16763370192173 913 1114046 YDL195W SEC31
SGTC_602 3130-1533 38.1 µM -0.966952203026192 0.138467606270993 no 2933 0.166783964096988 936 720941
SGTC_2467 5474540 200 µM -0.970622798188249 0.137564604990355 no 2934 0.165868074418554 889 5413519
SGTC_2401 5128683 200 µM -0.971637497319035 0.137315690165234 no 2935 0.165615460576412 942 708373
SGTC_2502 avocadyne acetate 18.59 µM -0.972880936849268 0.137011082906845 no 2936 0.165306240234299 912 3952079
SGTC_2295 7971645 200 µM -0.976410138375238 0.136149045446774 no 2937 0.164430629691222 954 2978226 YKL099C UTP11
SGTC_835 0312-0010 67.2 µM -0.977557123352085 0.135869685583607 no 2938 0.164146706151359 927 1626196
SGTC_433 pimozide 108 µM -0.977886256011529 0.135789594502807 no 2939 0.164065291723393 924 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_2521 angolensin 13.4 µM -0.979758098327955 0.135334715622939 no 2940 0.163602770032894 920 821428 A flavenoid.
SGTC_3283 9109332 35.8195 µM -0.982342116034328 0.134708487917308 no 2941 0.162965666281626 897 17027281
SGTC_366 0181-0206 4.31 µM -0.982482471285086 0.134674530341288 no 2942 0.162931107170516 944 274874
SGTC_1590 st077108 57.8 µM -0.983148262460364 0.13451352872901 no 2943 0.162767236992936 909 5489485
SGTC_233 rapamycin 362 pM -0.985141007210589 0.134032433009955 no 2944 0.16227740651428 923 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_854 0422-0053 192 µM -0.985409059830934 0.133967809090639 no 2945 0.162211590622428 924 3596728
SGTC_2930 9013230 14.89 µM -0.987369751979891 0.133495763411764 no 2946 0.161730703649232 894 2995857
SGTC_2455 5377712 9.75 µM -0.987564014005423 0.133449056295821 no 2947 0.161683108828884 892 2243908
SGTC_1037 k284-1091 78.7 µM -0.991238390545973 0.13256772937994 no 2948 0.160784594338116 917 3334711
SGTC_3167 9103034 49.47 µM -0.996467387985338 0.131320442115284 no 2949 0.159511552435343 934 5127859
SGTC_2508 celastrol 40.54 µM -0.996478343708976 0.13131783735176 no 2950 0.159508892120689 883 122724 Celastrol is a natural product and antioxidant.
SGTC_3027 9089541 49.47 µM -0.998111462732874 0.130929956291319 no 2951 0.159112656165136 938 9943819
SGTC_1765 st044815 90.4 µM -0.998933401224875 0.130735037999012 no 2952 0.158913477246753 934 645695
SGTC_2225 6654152 15.4 µM -1.00012456520767 0.130452916011913 no 2953 0.158625114675176 904 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -1.0009241975881 0.130263762948869 no 2954 0.158431728510032 932 1377
SGTC_2952 9073731 13.78 µM -1.00156819501696 0.130111563351907 no 2955 0.158276094178405 955 16457353
SGTC_2433 5607874 27.82 µM -1.00202268612203 0.130004224970811 no 2956 0.158166318087168 915 2252428
SGTC_3224 9130643 49.47 µM -1.00494522737315 0.129315464946614 no 2957 0.157461612399172 935 17644395
SGTC_1481 3346-2004 36 µM -1.00540854814295 0.129206506069383 no 2958 0.15735008271284 936 2770522
SGTC_2285 7945142 200 µM -1.00741247494602 0.128735976733068 no 2959 0.156868299452201 913 2970608
SGTC_905 2-aminofluorene 215 µM -1.00978830961847 0.128179663997668 no 2960 0.15629836110569 931 1539 An established DNA mutagen. YPR165W RHO1
SGTC_555 4296-0685 37 µM -1.0106368681846 0.127981375306463 no 2961 0.156095131615218 936 2908540 YHR072W ERG7
SGTC_2908 7930301 100 µM -1.01286471551122 0.127461793028252 no 2962 0.155562392034564 912 2223178
SGTC_299 1273-0059 1.44 µM -1.01374930082457 0.127255895976062 no 2963 0.155351196399569 903 2848077
SGTC_3140 9094243 49.47 µM -1.01612401277525 0.126704300125793 no 2964 0.154785167752343 944 19291112
SGTC_1016 4226-1401 38 µM -1.0161625067626 0.126695372513191 no 2965 0.154776003686395 925 2901613
SGTC_1436 4092-1007 8.32 µM -1.01788243864106 0.126296928995228 no 2966 0.154366914136892 907 2881121
SGTC_1929 genistein trimethyl ether 50.5 µM -1.01908173016654 0.126019615523056 no 2967 0.15408208346873 905 136420
SGTC_1696 st025591 34.7925 µM -1.02108864878069 0.125556503786671 no 2968 0.1536062202898 914 2787147
SGTC_310 1273-0058 1.06 µM -1.02429367359527 0.124819385104085 no 2969 0.152848292594249 881 2734232
SGTC_3075 9116269 49.47 µM -1.02508083147977 0.124638811350461 no 2970 0.152662524641451 921 17015205 YNL244C SUI1
SGTC_2729 fluphenazine 10.66 µM -1.02612274023083 0.12440007874931 no 2971 0.152416866326925 924 3372 An atypical antipsychotic.
SGTC_2966 9084041 48.03 µM -1.02621697598155 0.124378502286233 no 2972 0.152394660631496 948 17741380
SGTC_293 4049-0273 38.5 µM -1.02777809682408 0.124021444731934 no 2973 0.152027110826408 918 1380311
SGTC_762 1165-0429 115 µM -1.02962317868142 0.123600365584498 no 2974 0.151593465102401 924 5967793
SGTC_3242 9133940 49.47 µM -1.03101720778954 0.123282889045651 no 2975 0.15126637519032 950 17248444
SGTC_2753 fluvastatin 17.09 µM -1.03485829946979 0.122411075586188 no 2976 0.150367545832228 947 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_345 1362-0200 395 µM -1.03514335017924 0.12234655045371 no 2977 0.15030098507283 973 1419823
SGTC_1783 st039459 87.517 µM -1.03683145632374 0.121964913818685 no 2978 0.149907206371148 954 729761
SGTC_630 4356-0227 183 µM -1.03873831437175 0.121534829677095 no 2979 0.149463228416356 934 779312
SGTC_3087 9117406 49.47 µM -1.03895486245205 0.12148605561973 no 2980 0.149412864601776 913 42546093
SGTC_2621 lithochol-11-enic acid 100 µM -1.04106149014698 0.121012288746655 no 2981 0.148923505451977 962 6708711
SGTC_307 1501-1223 22.3 µM -1.04251242928315 0.120686738874119 no 2982 0.148587082973872 941 2830329
SGTC_89 0302-0250 142.109 µM -1.0435826526119 0.120447006343253 no 2983 0.1483392611567 959 4203518 YLR208W SEC13
SGTC_2529 gangaleoidin 93.61 µM -1.04474574700764 0.120186850997499 no 2984 0.148070247714662 946 4565183
SGTC_1035 k081-0041 55.2 µM -1.04821458736876 0.119413309655042 no 2985 0.14726987559305 921 731709
SGTC_2387 9077560 195.08 µM -1.05191243435466 0.11859257614734 no 2986 0.146419863250172 944 5303272
SGTC_890 0929-0006 47.2 µM -1.05730581859341 0.117402679339189 no 2987 0.145186019299374 949 1378169
SGTC_1225 1216-0074 20.6 µM -1.05784068232915 0.117285139296177 no 2988 0.145064041031941 949 4241466
SGTC_3216 9129716 49.47 µM -1.05799802445361 0.117250578136319 no 2989 0.1450281715317 925 8056934
SGTC_891 0929-0073 133 µM -1.05842338001185 0.117157182299901 no 2990 0.144931232528345 952 5603632
SGTC_2552 juarezic acid 87.02 µM -1.05943720343312 0.116934788408599 no 2991 0.144700356978785 954 1549512
SGTC_2434 5670830 169.91 µM -1.06036833314167 0.116730798073397 no 2992 0.144488531415459 974 1549830
SGTC_2881 9058953 51.95 µM -1.06068937197046 0.116660523949729 no 2993 0.14441554576728 912 17122249
SGTC_2727 riluzole 51.77 µM -1.06141109578189 0.116502651013231 no 2994 0.144251558267643 952 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_3020 9089140 49.47 µM -1.06225040171641 0.116319248309863 no 2995 0.144061012106124 959 17217859
SGTC_1658 st012944 20 µM -1.06552534704853 0.115605576098165 no 2996 0.143319130791868 945 24207260
SGTC_3355 9151058 44.0485 µM -1.06562581143254 0.115583732303438 no 2997 0.143296413211597 936 17015728
SGTC_803 4488-1585 147 µM -1.06771504709836 0.115130137857198 no 2998 0.142824534418909 934 747204
SGTC_312 4092-0653 6.84 µM -1.0687350313287 0.114909149217053 no 2999 0.142594540803047 926 1148278
SGTC_2504 purpurogallin 52.29 µM -1.06914924604189 0.114819492118892 no 3000 0.142501212138534 938 5281571 An antioxidant.
SGTC_2222 6885208 172.143 µM -1.06998451876302 0.11463884807152 no 3001 0.142313138590989 962 609514
SGTC_2982 9019404 25.97 µM -1.07020822895331 0.11459050072816 no 3002 0.1422627955819 931 22333232
SGTC_2800 7887935 81.82 µM -1.07198142994633 0.114207797000451 no 3003 0.141864186543799 978 2961002
SGTC_1725 st036284 20.55 µM -1.07226284838272 0.114147143244073 no 3004 0.141800994324207 940 707914
SGTC_1055 3448-0672 86 µM -1.07387139352385 0.113800895909108 no 3005 0.14144016308396 948 748378
SGTC_821 1114-0266 29.2 µM -1.07587936388651 0.113369721588444 no 3006 0.140990606074674 935 3123235
SGTC_2300 7976697 71.57 µM -1.07663556464953 0.113207643942816 no 3007 0.140821554590882 932 2236109
SGTC_2221 6807166 181.081 µM -1.07674585094556 0.113184019935314 no 3008 0.140796911176431 919 674925
SGTC_2739 tacrine 100.86 µM -1.08334895223104 0.111775998720779 no 3009 0.139326782392826 900 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_3220 9131269 49.47 µM -1.08341687736619 0.111761580009639 no 3010 0.139311713864655 953 17722206
SGTC_1539 benzyladenosine 56 µM -1.08676763690737 0.111051953118831 no 3011 0.138569756876248 929 92208 A nucleotide analog.
SGTC_1485 3909-9022 254 µM -1.08933115642501 0.110511231597356 no 3012 0.138003939042891 971 714516
SGTC_1949 st076024 69.1 µM -1.09342794294459 0.109651021809098 no 3013 0.137102975215725 959 2921930
SGTC_524 r073-0010 27.8 µM -1.09371087088011 0.109591792868293 no 3014 0.137040902491812 956 2772106
SGTC_745 0469-0705 296 µM -1.09552680841525 0.109212186173448 no 3015 0.136642953652097 950 3486736
SGTC_1116 jasmonic acid 1.58368 µM -1.09598360612814 0.109116845291927 no 3016 0.136542974430245 952 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_901 1112-0062 60.1 µM -1.09719050368108 0.108865234570252 no 3017 0.136279061765077 930 1908457
SGTC_91 0417-1751 58.384 µM -1.09992986079265 0.108295689330616 no 3018 0.135681341514851 982 6795624
SGTC_306 1672-3436 11.6 µM -1.10129123164491 0.10801344298324 no 3019 0.135384963076238 949 6797378
SGTC_1942 st076330 65.2 µM -1.10193309517023 0.107880552453741 no 3020 0.135245379645138 966 24208414
SGTC_1383 3049-0032 20.7 µM -1.1042452367632 0.107402826014539 no 3021 0.134743385663124 953 712864
SGTC_2163 5671233 125 µM -1.10504786750781 0.107237346394287 no 3022 0.134569424124306 924 701023
SGTC_244 nsc-207895 1.295 µM -1.1055530040776 0.107133295906352 no 3023 0.13446002030832 918 42640
SGTC_1646 st011709 75.6 µM -1.10811520027281 0.106606643428493 no 3024 0.133906033584661 959 5757843
SGTC_496 calpeptin 138 µM -1.11190527096275 0.105831035370818 no 3025 0.133089441085216 943 73364 A calpain inhibitor.
SGTC_2219 9098279 200 µM -1.11238327175527 0.10573350666696 no 3026 0.132986696986391 938 902349
SGTC_1578 josamycin 24.2 µM -1.11325902886165 0.105554990514141 no 3027 0.132798598668282 959 5282165 A P450 substrate.
SGTC_717 1532-0246 73.2 µM -1.11362590038094 0.105480271474212 no 3028 0.132719855138708 944 9561992
SGTC_1812 st052057 4.327 µM -1.11538402541941 0.105122733103961 no 3029 0.132342946039226 967 3645418
SGTC_3041 9091929 49.47 µM -1.11643573935442 0.104909272638459 no 3030 0.132117831243186 949 25236887
SGTC_1767 st044992 70.3 µM -1.1186035895692 0.104470266703018 no 3031 0.131654645713289 955 9600693
SGTC_1712 st032288 53.4 µM -1.11930368009249 0.104328777849542 no 3032 0.131505303187397 958 2883011
SGTC_1573 oleylamine 1.06 µM -1.11932503941818 0.104324463296957 no 3033 0.131500748679025 955 5356789 An amine of the fatty acid oleic acid.
SGTC_2601 securinine 100 µM -1.11970554129265 0.104247624143526 no 3034 0.131419631454137 954 442872 A GABA receptor antagonist.
SGTC_1335 1486-0900 202 µM -1.12088264600353 0.104010177504218 no 3035 0.131168909362549 950 X1335
SGTC_1368 1852-0141 284 µM -1.12103065637262 0.103980348495899 no 3036 0.131137406705506 978 2838987
SGTC_205 1486-1330 71.903 µM -1.12310549121315 0.103562853157173 no 3037 0.13069634712623 965 4118834
SGTC_1874 staurosporine 7.6 µM -1.12459196617626 0.103264495619412 no 3038 0.130380989817954 947 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_3238 9133470 49.47 µM -1.12525046018538 0.103132525777168 no 3039 0.130241457948919 929 3534688
SGTC_1205 4161-2785 76 µM -1.12559532641716 0.103063459472644 no 3040 0.130168423609642 963 3498106
SGTC_2423 st077119 87.2 µM -1.13262177017718 0.101663582480139 no 3041 0.128686561192109 942 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_3174 9107204 49.47 µM -1.13324108678248 0.10154086329799 no 3042 0.128556512194892 968 3938802
SGTC_1685 st024049 53.0905 µM -1.13536832152024 0.101120167968239 no 3043 0.128110513462441 959 1941139
SGTC_202 3594-0513 34.79 µM -1.13550846909159 0.101092496171071 no 3044 0.128081167726847 963 708429
SGTC_713 1488-1073 324 µM -1.13719151789897 0.100760613307789 no 3045 0.127729116026318 970 3312542
SGTC_1989 st071868 50.2 µM -1.1395931896407 0.100288401081508 no 3046 0.127227911980495 945 16414057
SGTC_1061 3448-9325 110 µM -1.14031261686567 0.100147263524162 no 3047 0.127078041637994 950 723482
SGTC_2323 6148992 148.28 µM -1.14180149591697 0.0998556352450757 no 3048 0.126768270211083 958 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_431 k089-0097 107 µM -1.14383129208939 0.0994590569077194 no 3049 0.126346804879716 916 5499420
SGTC_2682 pyrogallin 40.03 µM -1.14426539833738 0.0993743915586408 no 3050 0.126256794276553 958 822798 An ATP competetive kinase inhibitor.
SGTC_1564 D-Arginine 115 µM -1.14472290095941 0.0992852201640296 no 3051 0.126161980885405 975 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_2464 5717415 7.67 µM -1.14810381951205 0.0986280616705331 no 3052 0.125462853802179 962 5285744
SGTC_3106 9121286 49.47 µM -1.15239304010902 0.0977989432079518 no 3053 0.124579799844734 935 15943471
SGTC_823 0417-1665 178 µM -1.15319113177481 0.0976452352792611 no 3054 0.124415971346351 983 3429856
SGTC_3113 9123498 49.47 µM -1.15414404089033 0.097461942489964 no 3055 0.124220560047564 983 8897275
SGTC_1943 st076331 65.2 µM -1.1543435938039 0.0974235903147916 no 3056 0.12417966530527 966 24208415
SGTC_1729 st035615 45.989 µM -1.15470236349551 0.0973546660318284 no 3057 0.124106165668116 946 17385451
SGTC_1076 itraconazole 331 nM -1.15945473359649 0.096445047528237 no 3058 0.123135438796448 967 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -1.16036862542659 0.0962708440161959 no 3059 0.122949377505004 975 364106
SGTC_2698 st077697 67.5 µM -1.16494675187715 0.0954016546024001 no 3060 0.122020273724166 967 3154499
SGTC_3335 9143315 29.6265 µM -1.17400053147957 0.0936997645884514 no 3061 0.120197406372297 943 4899691
SGTC_1176 0848-0131 83.3 µM -1.17643660593282 0.0932456922229713 no 3062 0.119710225521501 971 6769040
SGTC_2856 9022925 19.48 µM -1.1799143056638 0.0926002862761997 no 3063 0.11901714975983 966 4944862
SGTC_1835 st008666 49.2 µM -1.18782350391073 0.0911447785077832 no 3064 0.1174514761723 949 690455
SGTC_1166 k206-0078 225 µM -1.18802225731152 0.0911084222636907 no 3065 0.117412320474613 965 5404595
SGTC_731 3966-0296 387 µM -1.19299094405106 0.0902030352604814 no 3066 0.116436459863644 968 660956
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -1.19386236425623 0.0900449375534837 no 3067 0.116265905824569 975 66535 A nucleotide analog.
SGTC_2728 chlorpromazine 9.18 µM -1.19525002564268 0.0897936057265832 no 3068 0.115994679287176 1008 2726 A thorazine and dopamine antagonist.
SGTC_1947 st076332 61.6 µM -1.19698538496401 0.0894800334911503 no 3069 0.115656125658237 963 24208416
SGTC_3200 9114385 49.47 µM -1.19744745651504 0.0893966765389555 no 3070 0.115566097936422 954 17018030 YLR208W SEC13
SGTC_982 1491-0518 27.5 µM -1.19852713226941 0.0892021299866457 no 3071 0.115355933394523 970 3091256
SGTC_2056 5235370 200 µM -1.19966596526267 0.0889972654892625 no 3072 0.115134548110383 984 5511916
SGTC_3097 9117246 49.47 µM -1.20058838522991 0.0888315883799752 no 3073 0.114955454348198 965 16423892
SGTC_664 1222-0054 14.9 µM -1.20169423422299 0.0886332681524729 no 3074 0.114741007930791 976 6813991
SGTC_598 3937-0236 20.2 µM -1.20355176885907 0.0883008849941047 no 3075 0.114381435399774 975 1379313
SGTC_2811 7967822 32.47 µM -1.20463242399115 0.0881079428511399 no 3076 0.11417261692343 967 2232244
SGTC_3085 9117376 49.47 µM -1.20815813470107 0.0874806414999048 no 3077 0.113493220879782 956 16480349
SGTC_1839 st053978 48 µM -1.21498953545263 0.0862746814698938 no 3078 0.112185041298258 992 3788398
SGTC_1005 4092-0690 4.4 µM -1.21821540273301 0.0857095536988949 no 3079 0.111571063966628 989 1529343
SGTC_870 0573-2213 57.6 µM -1.22203520241207 0.0850439660997713 no 3080 0.110847157534166 976 3916321
SGTC_2244 6635614 200 µM -1.22841176555266 0.0839415135824828 no 3081 0.109646216694644 991 836499
SGTC_2993 9054257 71.4286 µM -1.2294477898518 0.0837634120450474 no 3082 0.109451980839722 961 6470217 YGL055W OLE1
SGTC_3312 9133330 71.43 µM -1.23027100318457 0.0836220970528703 no 3083 0.109297819487698 994 17617324
SGTC_272 doxorubicin 8.13 µM -1.23075717705258 0.0835387233283661 no 3084 0.109206848074008 985 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_126 0417-1624 672.48 µM -1.2334769021261 0.0830734707672729 no 3085 0.108698944555611 972 41912 YDL195W SEC31
SGTC_24 0417-1663 219 µM -1.23417847636693 0.0829537720222611 no 3086 0.108568202960386 1012 4329390
SGTC_127 0180-0333 59.125 µM -1.23423247558906 0.0829445643513741 no 3087 0.10855814464665 914 771601
SGTC_2883 9059145 45.46 µM -1.23459360959737 0.0828830053919958 no 3088 0.108490894258287 999 16476510
SGTC_1278 0874-0585 172 µM -1.23487725829136 0.0828346786965686 no 3089 0.108438094207526 990 766306
SGTC_784 4579-0127 173 µM -1.23595906443712 0.0826505603935327 no 3090 0.108236890119506 982 1948547
SGTC_1648 st011736 69.8 µM -1.23728259746044 0.0824257204498524 no 3091 0.107991093132653 979 2855514
SGTC_2630 antimycin a 100 µM -1.23729577365459 0.0824234844138062 no 3092 0.107988648167354 992 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_2733 amorolfine 100 µM -1.24015141040679 0.0819399518698594 no 3093 0.107459698274208 1036 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_3187 9109394 49.47 µM -1.24200914666162 0.0816265390293319 no 3094 0.107116593668427 975 17098090
SGTC_2964 9083345 53.42 µM -1.24528125965181 0.0810767103911491 no 3095 0.106514190916603 957 17741579
SGTC_1888 azatryptophan 97.5 µM -1.24666357844604 0.0808452744123782 no 3096 0.106260439394191 977 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_3025 9087895 49.47 µM -1.24970499204248 0.0803378194541923 no 3097 0.105703666535851 988 17173641
SGTC_2216 7189485 200 µM -1.25003801906685 0.0802824009631268 no 3098 0.105642829684073 971 731273
SGTC_1353 1498-1206 8.11 µM -1.25315491836115 0.079765122542962 no 3099 0.105074666424315 903 6756808
SGTC_1601 4'-hydroxyflavanone 55.5 µM -1.25321164442842 0.0797557317383935 no 3100 0.105064346657714 989 165506
SGTC_2325 6158266 200 µM -1.25430768737438 0.0795744497564665 no 3101 0.104865095426576 976 3623240
SGTC_2540 epiandrosterone 100 µM -1.26183105875891 0.078338513788522 no 3102 0.103504791803232 981 441302 A steroid.
SGTC_14 0354-0009 295 µM -1.26256871711419 0.0782181195643183 no 3103 0.10337210811842 991 1713507
SGTC_3054 9094397 49.47 µM -1.26311738053986 0.0781286625048063 no 3104 0.103273499331271 993 2598354
SGTC_279 1273-0055 2.93 µM -1.26667763363895 0.0775500642724055 no 3105 0.102635290310464 1008 2847562
SGTC_1376 2910-0861 41.3 µM -1.26784717904381 0.0773607060764835 no 3106 0.102426265091935 998 1112859
SGTC_2507 purpurin 79.67 µM -1.27349150187088 0.0764517821199908 no 3107 0.101421843116855 985 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_400 oxethazaine 37.5 µM -1.27673616124494 0.0759329742388349 no 3108 0.100847705135081 993 4621 A local anesthetic.
SGTC_3286 9117135 37.221 µM -1.27716416458472 0.0758647388595637 no 3109 0.100772147812238 979 3438150
SGTC_3254 9136651 49.47 µM -1.27897324719811 0.0755768376076718 no 3110 0.100453238460994 1007 16454030
SGTC_2887 9044784 58.44 µM -1.28227512590687 0.0750535169363611 no 3111 0.0998730752309352 979 6465546
SGTC_3128 9127691 49.47 µM -1.28948317802431 0.0739207064890749 no 3112 0.0986150804173498 993 41316314
SGTC_2797 7859098 81.82 µM -1.28963641047273 0.0738967672426097 no 3113 0.0985884638121885 967 972681
SGTC_2773 thioridazine 9.09 µM -1.29136873443528 0.0736265411276788 no 3114 0.098287923401763 996 5452 An antipsychotic.
SGTC_2358 9037157 4 µM -1.29430318569413 0.0731705192284129 no 3115 0.0977803582664914 976 2388925
SGTC_3122 9126309 49.47 µM -1.29594779072722 0.0729158897526961 no 3116 0.0974967363529298 1022 17591206
SGTC_389 tpck 16.7 µM -1.29683452872725 0.0727788804002511 no 3117 0.0973440637115095 1010 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -1.29754441361231 0.0726693386505157 no 3118 0.0972219669274436 987 5355888
SGTC_1168 k815-0004 80.5 µM -1.30043758456925 0.0722242013924056 no 3119 0.0967255176613311 1003 642433
SGTC_775 4577-0580 57.3 µM -1.30049983671977 0.0722146464242454 no 3120 0.0967148560974397 1003 2006902
SGTC_1484 3473-2379 286 µM -1.30051781007635 0.0722118879070259 no 3121 0.0967117780657274 1027 671917
SGTC_383 2324-0395 7.37 µM -1.30338958961499 0.07177216903461 no 3122 0.0962208944069166 918 3146421
SGTC_1606 st000094 49.2 µM -1.30572904432879 0.0714154786339355 no 3123 0.0958223586296627 980 1242210
SGTC_2855 9016525 58.44 µM -1.30589683370249 0.0713899486188106 no 3124 0.0957938217516371 982 43811474
SGTC_2124 5246320 200 µM -1.30863508526443 0.0709742988824998 no 3125 0.0953289951559726 981 579342
SGTC_2033 5192550 145 µM -1.30873557999211 0.0709590798371672 no 3126 0.0953119675129707 973 182073
SGTC_1613 st002381 52.1 µM -1.31119870622379 0.0705868441069449 no 3127 0.0948953196808137 982 551167
SGTC_1833 st055984 71 µM -1.31245457018651 0.0703976324186175 no 3128 0.0946834024069178 994 676288
SGTC_2832 7992762 51.95 µM -1.31308375146379 0.0703029850935969 no 3129 0.0945773642014327 986 2985177
SGTC_1734 st037168 69.4 µM -1.31636881418568 0.0698104037539581 no 3130 0.0940251421573592 1003 708907
SGTC_3310 9130229 44.1445 µM -1.33006164157819 0.0677857902549314 no 3131 0.0917489812504929 1011 7761258
SGTC_469 w7 172 µM -1.33157749555866 0.0675644742802741 no 3132 0.0914995320170794 995 45115570 A P450 inhibitor.
SGTC_1337 1486-1011 40.3 µM -1.33365151007827 0.0672625714722147 no 3133 0.0911590466026835 998 X1337
SGTC_1785 bathophenanthroline 24 µM -1.33518177618094 0.0670404885307477 no 3134 0.0909084299286204 943 72812 An iron chelator.
SGTC_1897 st060201 15 µM -1.33643706700698 0.0668587356875464 no 3135 0.0907032287880738 1008 611878
SGTC_2403 6032726 181.2 µM -1.33738863421933 0.0667212130125309 no 3136 0.0905479062518142 995 2881040
SGTC_1129 3453-1384 223 µM -1.34069516601151 0.0662450468551478 no 3137 0.0900097223401164 1005 1084452
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -1.34112854358383 0.0661828327058814 no 3138 0.089939360680196 967 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_1957 st077035 62.4 µM -1.34532847982369 0.0655822470194367 no 3139 0.0892595901648681 1009 705593
SGTC_2450 5739737 12.93 µM -1.34594549075671 0.0654943723722076 no 3140 0.0891600482535283 988 2262825
SGTC_1741 st038134 10.228 µM -1.3467967936356 0.0653732798248792 no 3141 0.0890228438459886 1008 1272587
SGTC_1006 4099-6547 255 µM -1.34740253117529 0.0652872232219748 no 3142 0.0889253129198911 1012 3146833
SGTC_1050 3232-1156 69.3 µM -1.34871539229047 0.065101007874684 no 3143 0.0887141997931832 1002 700529
SGTC_1952 st077036 64.1 µM -1.34878730349254 0.0650908199569103 no 3144 0.0887026469863761 983 2937007
SGTC_96 0929-0093 37.281 µM -1.34901993094572 0.065057871267055 no 3145 0.0886652821803921 1001 6991579
SGTC_2691 st077356 60.2 µM -1.35609662833924 0.0640617216412167 no 3146 0.0875342127580809 1009 2839272
SGTC_1470 k295-0292 231 µM -1.3595846017775 0.063575120798628 no 3147 0.0869807068111253 1025 5045612
SGTC_232 clozapine 119 µM -1.3650185124473 0.0628227824897792 no 3148 0.086123615805196 1005 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_1243 0416-0003 5.65 µM -1.37538129628115 0.0614072784272185 no 3149 0.084506632243721 999 2141977
SGTC_793 0488-0545 106 µM -1.3827171565427 0.0604203877261178 no 3150 0.0833758046020942 1012 292548
SGTC_824 1304-0008 100 µM -1.38351841254335 0.060313351182116 no 3151 0.0832529827945784 1006 768245
SGTC_251 melphalan 456.522 µM -1.38386480170176 0.060267124429414 no 3152 0.0831999281125602 1021 460612 A DNA alkylator.
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -1.38674595371192 0.0598836992936956 no 3153 0.082759621299375 1023 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_13 0199-0087 65 µM -1.38715790822828 0.0598290326596089 no 3154 0.0826968086428629 1008 4589825
SGTC_1478 0453-0656 35.7 µM -1.38791632002735 0.0597284931581168 no 3155 0.0825812638379459 1034 5258496
SGTC_2218 6965428 192.983 µM -1.3891468274646 0.0595656515715724 no 3156 0.082394053371384 994 675684
SGTC_217 ketoconazole 989 nM -1.39191354198357 0.0592007837974561 no 3157 0.0819742902866233 944 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_3324 9138759 60.749 µM -1.39371145147341 0.0589646208748832 no 3158 0.081702378379687 1004 45595710
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -1.39428509938046 0.0588894255628541 no 3159 0.0816157643602657 1038 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -1.39495557864786 0.0588016327267583 no 3160 0.0815146177227365 989 5379071
SGTC_1543 azetidyl-2-carboxylic acid 198 µM -1.3984150983189 0.0583502730223956 no 3161 0.0809942259127726 1009 16486 A toxic proline analog.
SGTC_1059 3448-6867 171 µM -1.3987491462155 0.0583068346209194 no 3162 0.0809441104358716 1013 3934407
SGTC_2945 9067681 61.76 µM -1.40263604734618 0.0578032610832928 no 3163 0.0803626983987279 1021 16456930
SGTC_361 000s-0510 1.45 µM -1.40270310287142 0.0577946036988516 no 3164 0.0803526958342328 988 660
SGTC_1039 k821-0043 94 µM -1.40417664085737 0.0576046158253435 no 3165 0.0801331279617419 1029 15992768
SGTC_2364 9055074 200 µM -1.40547067816219 0.0574381769297435 no 3166 0.0799406812908005 1006 6470630
SGTC_657 3534-0529 86.7 µM -1.4066816210617 0.0572827685126229 no 3167 0.0797609089911502 1041 1049549
SGTC_1737 st035557 69.7 µM -1.40819870115381 0.0570885386200978 no 3168 0.0795361203851568 985 5716916
SGTC_1863 st057641 20.1 µM -1.40825544481618 0.0570812838697011 no 3169 0.0795277218803052 1040 3921635
SGTC_651 3253-0966 34.4 µM -1.41011221555829 0.0568442935122292 no 3170 0.0792532754268741 1023 781462
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -1.41025529584313 0.0568260635553602 no 3171 0.0792321567404655 1027 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_904 1141-0088 396 µM -1.41206647980011 0.0565956972082935 no 3172 0.0789651937311429 1020 1378119
SGTC_2223 6903751 107.57 µM -1.41651369749578 0.0560331722671036 no 3173 0.0783125783151453 999 5598863
SGTC_2803 7707263 71.43 µM -1.41758508067217 0.0558983152114488 no 3174 0.0781559692278895 1004 2199229
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -1.41823038125245 0.0558172136243252 no 3175 0.078061757324009 991 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_94 0334-0113 514.748 µM -1.41999994687831 0.0555952903682278 no 3176 0.0778038482591589 1002 6795178
SGTC_955 1216-0110 33 µM -1.42063710822579 0.0555155539771875 no 3177 0.0777111423662353 1009 3619719
SGTC_460 trequinsin 123 µM -1.42276655680071 0.0552497229369706 no 3178 0.0774019195980973 1052 5537 A vasodilator.
SGTC_666 0272-0154 136 µM -1.43005798747173 0.0543471010192436 no 3179 0.0763501884156835 1037 6870312
SGTC_2172 5754775 163.918 µM -1.43282805938571 0.054007261258658 no 3180 0.0759534902125001 995 2263357
SGTC_1676 st018489 23.4 µM -1.43289188913013 0.0539994503298423 no 3181 0.0759443677761751 999 3696235
SGTC_2116 5511452 16.8835 µM -1.44441982554181 0.0526033657716301 no 3182 0.0743104586266675 1015 870744
SGTC_209 4077-0173 175.592 µM -1.44492837547023 0.0525424440845132 no 3183 0.07423900252857 1016 15993494
SGTC_1945 st075991 56.6 µM -1.45060056654306 0.051866733779554 no 3184 0.0734455587309447 1014 1084980
SGTC_601 0986-0029 62.9 µM -1.45589613772753 0.0512421396084786 no 3185 0.0727106667643492 989 24747981
SGTC_1913 st060213 96.1 µM -1.45860873620086 0.0509245238253 no 3186 0.0723364138615875 1012 688959
SGTC_2947 9072639 7.68 µM -1.45887706197236 0.0508931911629706 no 3187 0.0722994737551921 1037 16488146
SGTC_146 3448-8650 53.125 µM -1.47013349920816 0.0495925364937215 no 3188 0.0707628005615009 1034 2891488 YIL048W NEO1
SGTC_872 0588-0139 234 µM -1.47099007311859 0.0494946575450995 no 3189 0.0706469007497079 1021 2047100
SGTC_3011 9081274 71.4286 µM -1.47116203425855 0.0494750264939988 no 3190 0.0706236509245663 1023 6625322
SGTC_3124 9127567 49.47 µM -1.4731282560083 0.0492510045186359 no 3191 0.0703582278455896 999 17592030
SGTC_2405 ticlatone 3.52 µM -1.47522078823003 0.049013481817977 no 3192 0.0700765971504628 1011 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_2862 9027634 71.43 µM -1.47626659713756 0.0488951158058399 no 3193 0.0699361687524235 996 5012562
SGTC_2732 terfenadine 20 µM -1.48266592638419 0.0481757983051963 no 3194 0.0690815959104368 1044 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_2775 cyproheptadine 69.59 µM -1.48510570729983 0.0479037938841771 no 3195 0.0687579122339451 1022 2913 A selective serotonin reuptake inhibitor.
SGTC_813 k007-0158 173 µM -1.48830994600466 0.0475484312987187 no 3196 0.0683345865965703 1022 6523916
SGTC_1280 0880-0253 10.1 µM -1.50708276681966 0.0455086794958355 no 3197 0.0658947217317842 1015 6836607
SGTC_2558 carylophyllene oxide 100 µM -1.50718529032321 0.0454977361665941 no 3198 0.0658815848056659 1029 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_2706 st078239 82.5 µM -1.51770882310955 0.044385666045276 no 3199 0.0645439094139793 1033 15434492
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -1.51844434698109 0.0443087660641531 no 3200 0.0644512096215974 1030 115019
SGTC_1554 st069299 38.7 µM -1.52326310000258 0.0438076116822574 no 3201 0.0638464475096302 1017 24207999
SGTC_2330 7979373 200 µM -1.52610616316361 0.043514082002214 no 3202 0.0634917137171724 1006 1863007
SGTC_125 0133-0007 11.75 µM -1.53038778262344 0.0430750274491952 no 3203 0.0629603856404791 1022 26541
SGTC_3001 9076041 71.4286 µM -1.5381549574752 0.042287688884859 no 3204 0.0620053655932374 1024 16004211
SGTC_1519 esterone 74 µM -1.53955405408314 0.0421471113009445 no 3205 0.0618345461671639 1038 698 A steroid.
SGTC_3091 9116372 49.47 µM -1.54160042515358 0.0419421786199551 no 3206 0.0615853610943406 1033 17169793
SGTC_3331 9141060 1.957 µM -1.54529973386931 0.0415737611758341 no 3207 0.0611368899108534 1021 4906567 YPR165W RHO1
SGTC_796 1234-0020 70.7 µM -1.54720344895896 0.0413851927671378 no 3208 0.0609070972905773 994 46495034
SGTC_1770 st043884 66.3 µM -1.55095843349176 0.0410152830355283 no 3209 0.0604558227674973 1037 670149
SGTC_1160 4092-0570 10.5 µM -1.55116768384756 0.040994748571644 no 3210 0.0604307521993816 1038 4994975
SGTC_531 3788-1495 174 µM -1.55421924581528 0.0406962345882045 no 3211 0.0600660641330431 1010 2896655
SGTC_350 k064-0020 19.8 µM -1.55571977440577 0.040550096173166 no 3212 0.0598873711365802 975 2790705
SGTC_773 4358-1457 44.6 µM -1.55584612527582 0.0405378101692532 no 3213 0.0598723434556759 1053 1186886
SGTC_3053 9095903 49.47 µM -1.55650305541761 0.0404739808168588 no 3214 0.0597942583368819 1059 17174018
SGTC_3300 9124615 50.48 µM -1.55743206682794 0.0403838545247048 no 3215 0.0596839688568301 1026 24824903
SGTC_2951 9072950 58.06 µM -1.5682693215694 0.0393444903944893 no 3216 0.0584091461813722 1008 16488155
SGTC_1872 amphotericin b 148 nM -1.56838723293588 0.0393333027629479 no 3217 0.0583953944066602 1019 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_2028 5153890 36.43 µM -1.58307440693226 0.0379598714133468 no 3218 0.0567022530703765 1040 2830968 YPR165W RHO1
SGTC_913 3487-1245 167 µM -1.5835759476997 0.037913670995673 no 3219 0.0566451254871293 1003 4016153
SGTC_652 0437-0092 114 µM -1.59522298201412 0.0368536237455909 no 3220 0.0553311906258978 1032 3091274
SGTC_770 0389-1121 67.2 µM -1.5989857800386 0.0365163799469384 no 3221 0.0549118811325843 1044 6753108
SGTC_3158 9100007 49.47 µM -1.60115012776143 0.0363235452229071 no 3222 0.0546718359047107 1041 19297233
SGTC_1931 st074438 57.1 µM -1.60141764693316 0.03629976832152 no 3223 0.0546422233723794 1042 2787313
SGTC_1388 3346-4487 254 µM -1.61285533858831 0.0352950518671666 no 3224 0.0533879700555769 1048 3345614
SGTC_2688 kanamycin b 96.69 µM -1.62167385535789 0.0345360804714039 no 3225 0.0524365998364194 1001 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_1616 st002734 56.1 µM -1.62574062264801 0.0341906162052425 no 3226 0.0520024222304686 1043 4026101
SGTC_547 1120-0019 610 nM -1.63441499295188 0.0334632328652898 no 3227 0.0510858711066947 982 3676939
SGTC_779 1360-0071 233 µM -1.63654597407801 0.0332865037310187 no 3228 0.0508626860332658 1022 7566
SGTC_395 anisomycin 6.25 µM -1.64333967578031 0.0327282052203563 no 3229 0.0501563368402542 1045 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_578 3460-0051 92 µM -1.64406723548234 0.032668875616565 no 3230 0.0500811574566154 1049 2876744
SGTC_2189 6047310 154.431 µM -1.65880013229078 0.0314864253305203 no 3231 0.0485780368473469 1035 711535
SGTC_2726 cimetidine 79.27 µM -1.65914080199444 0.0314595075949875 no 3232 0.0485437115241717 1054 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_301 4119-0100 24.5 µM -1.66178760112912 0.031251020391451 no 3233 0.0482776845759982 1047 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_3116 9124943 49.47 µM -1.66347049585844 0.0311190547567102 no 3234 0.0481091460033546 1026 41905195 YPL160W CDC60
SGTC_2821 7996764 71.43 µM -1.66676377770835 0.0308621429702132 no 3235 0.0477806927259861 1007 2987135
SGTC_455 paf C-16 10 µM -1.67231629635337 0.0304329627144486 no 3236 0.0472309839119904 1032 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_1128 3448-9350 235 µM -1.67790445628531 0.0300060318610835 no 3237 0.0466828762282605 1034 619386
SGTC_322 k048-0136 19.3 µM -1.68270638802619 0.0296431468229391 no 3238 0.0462159722489468 1051 6823282
SGTC_2570 licareol 100 µM -1.68553546418251 0.0294310618967694 no 3239 0.0459426542569685 1036 443158
SGTC_1218 1348-1416 30.7 µM -1.69028712601477 0.0290776837752421 no 3240 0.0454865184299147 1033 6787668
SGTC_789 1309-1135 70.6 µM -1.69081456742387 0.0290386765815596 no 3241 0.0454361120278529 1037 3092424
SGTC_2666 tannic acid 100 µM -1.69158298216253 0.0289819259107075 no 3242 0.0453627567485375 1027 16134267 A thiamine antagonist.
SGTC_1123 mangostin 811.285 nM -1.70537939671638 0.0279785873494108 no 3243 0.044061844194279 1009 5281650 An antioxidant.
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -1.70934318979138 0.0276957304542384 no 3244 0.0436936987383742 1049 689007
SGTC_2737 bleomycin 30.5 nM -1.72001133608209 0.0269462668846508 no 3245 0.0427151904991185 1038 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_59 0330-0160 1.33 µM -1.73299874065361 0.0260567948635858 no 3246 0.0415479463144333 1054 4293482
SGTC_2432 5630864 12.22 µM -1.7383701716742 0.025696166948499 no 3247 0.0410728045281682 1048 5714970
SGTC_73 0327-0325 16.231 µM -1.73951627024666 0.0256197632811711 no 3248 0.0409719964268486 972 53298
SGTC_660 4031-1742 102 µM -1.73951712146086 0.0256197066064735 no 3249 0.0409719216307222 1019 6738706
SGTC_2802 7925815 54.55 µM -1.74286272715508 0.0253977623053257 no 3250 0.0406787980583624 1042 1262923
SGTC_1694 st024011 44.9 µM -1.74833309383832 0.0250383338504022 no 3251 0.0402031829576368 1059 2787533
SGTC_1465 k213-0056 144 µM -1.75366291258889 0.0246922509934865 no 3252 0.0397441420086411 1013 24048857 YMR208W ERG12
SGTC_914 3820-6779 408 µM -1.75777874458944 0.024427750482579 no 3253 0.0393925816539174 1038 2893481
SGTC_1260 0700-1617 7.75 µM -1.7586691941229 0.0243708405271314 no 3254 0.0393168563627736 1026 2853078
SGTC_2836 9010338 19.48 µM -1.7682597579044 0.0237649184991168 no 3255 0.0385087440676139 1055 2994051
SGTC_2992 9074591 71.4286 µM -1.7691074406824 0.02371197734917 no 3256 0.0384379732187599 1044 17741321
SGTC_754 3474-0146 171 µM -1.7742438047061 0.0233933077272331 no 3257 0.0380114156737516 1039 24762078
SGTC_246 cycloheximide 667 µM -1.77597432907779 0.0232867576418343 no 3258 0.0378685742082945 1052 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_1879 gemcitabine 100 µM -1.78040950154178 0.0230155432390527 no 3259 0.0375044839584794 1056 60750 A nucleoside analog which inhibits DNA replication.
SGTC_3321 9137793 26.8275 µM -1.78760254154771 0.0225813407997059 no 3260 0.0369200775758874 1047 4904192
SGTC_1075 aripiprazole 15.2 µM -1.78859287865396 0.0225221042030352 no 3261 0.0368402027891542 1062 60795 An atypical antipschotic. YIL048W NEO1
SGTC_207 4185-0010 4.486 µM -1.79444263653449 0.0221748699939471 no 3262 0.0363712733860318 1038 3761753
SGTC_302 1094-0063 18.9 µM -1.81284868558922 0.021111643971221 no 3263 0.0349275812734152 1049 5440289
SGTC_1702 st027038 51 µM -1.82004817201499 0.0207076632621345 no 3264 0.0343758346317561 1060 5521182
SGTC_2001 4023502 57.655 µM -1.82174207957835 0.0206135711571881 no 3265 0.0342470649339249 1034 108941 YCR052W RSC6
SGTC_3285 9112818 20.8695 µM -1.84354641920454 0.0194343801252901 no 3266 0.0326246354123048 1053 17017947 YPR165W RHO1
SGTC_21 0849-0113 22.993 µM -1.84701134779764 0.0192523750214017 no 3267 0.032372747827911 1060 1560156
SGTC_343 4130-2827 29.8 µM -1.84887567466634 0.0191550468680307 no 3268 0.0322378834662683 1066 1118244
SGTC_2283 7944793 200 µM -1.85020190199246 0.0190860653723566 no 3269 0.0321422274710155 1035 2970533
SGTC_1647 st011722 22.4 µM -1.85212110884714 0.0189866151087599 no 3270 0.0320042169856995 1043 2854783
SGTC_3250 9135583 49.47 µM -1.85624087513427 0.0187746229817268 no 3271 0.0317096161532598 1061 7699353
SGTC_825 1988-2224 89.6 µM -1.85813542096015 0.0186778128571855 no 3272 0.0315748929478247 1059 1180859
SGTC_981 1488-1094 54.9 µM -1.86352039693094 0.0184049610686152 no 3273 0.0311945427824292 1053 3449522
SGTC_3206 9114350 49.47 µM -1.88166373113114 0.0175105079494382 no 3274 0.0299408435605458 1041 17087243
SGTC_1094 duloxetine 25.4 µM -1.8836142403564 0.0174165962988585 no 3275 0.0298085871088779 1058 60834 A selective serotonin reuptake inhibitor.
SGTC_1461 k072-0203 53.8 µM -1.89100784102607 0.0170645100205757 no 3276 0.0293116487705264 1040 5418714
SGTC_16 erodoxin 22.806 µM -1.89107214511526 0.017061474718084 no 3277 0.0293073571321575 1063 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_993 3909-8757 62.7 µM -1.90435766247144 0.0164441844331641 no 3278 0.028431809575312 1055 4288324 YLR208W SEC13
SGTC_1036 k216-0215 33.5 µM -1.94756934270658 0.0145669176089263 no 3279 0.0257332575173639 961 622330
SGTC_3026 9090633 49.47 µM -1.96586941410341 0.0138292972803874 no 3280 0.0246568484796376 1057 25236842
SGTC_321 4534-3890 65.3 µM -1.97542254671403 0.0134571996984972 no 3281 0.0241101081114125 1055 699746
SGTC_1241 0364-0022 50.8 µM -1.9793312049866 0.0133074664835854 no 3282 0.0238893642335087 1060 4563895
SGTC_1030 k029-0042 36.7 µM -1.98282189049969 0.0131749636189947 no 3283 0.0236936639690702 1055 6080581
SGTC_957 1187-1561 14.1 µM -1.98403581116225 0.0131291523539099 no 3284 0.0236259239410399 1054 1538454
SGTC_1381 2324-0066 62.1 µM -1.98453392719374 0.0131103941877789 no 3285 0.0235981748989317 1068 10885928
SGTC_1259 0671-0132 43 µM -1.99034293455006 0.0128933417528459 no 3286 0.0232765857356308 1060 X1259
SGTC_633 0437-0093 97.7 µM -1.99882317205854 0.0125820618250778 no 3287 0.0228137448435499 1061 2831118
SGTC_1171 0368-0077 21.4 µM -1.99932050585199 0.0125640101181697 no 3288 0.0227868434307335 1065 3239779
SGTC_766 1391-0721 126 µM -2.00438580841519 0.0123814284082014 no 3289 0.0225143741704382 1070 1020919 YIL115C NUP159
SGTC_1459 k035-0031 35.7 µM -2.00855627776532 0.0122328309303133 no 3290 0.0222921060286849 1034 3877128 YMR208W ERG12
SGTC_2304 7443016 91.4 µM -2.01272412527825 0.0120858733332112 no 3291 0.0220718299513435 1063 939854
SGTC_2037 5169046 200 µM -2.01621774892889 0.011963870384309 no 3292 0.021888605627472 1068 5718022
SGTC_320 4092-0846 5.34 µM -2.02615703454458 0.0116225991074989 no 3293 0.021374347487504 1059 1359356
SGTC_3181 9108277 49.47 µM -2.03192003991494 0.0114286195959878 no 3294 0.0210808757116097 1070 17097298
SGTC_2841 9004761 38.96 µM -2.03621795336125 0.0112857910410127 no 3295 0.0208642371221086 1056 2991039
SGTC_1873 rapamycin 2 nM -2.03660508555451 0.0112730023322321 no 3296 0.0208448163782182 1054 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_1441 4106-0040 13 µM -2.04945350041983 0.0108556481801502 no 3297 0.020208895164244 1073 2904180
SGTC_2042 p-Dimethylaminoacetophenone 200 µM -2.06834698353455 0.0102663766117483 no 3298 0.0193037033494912 1084 75037 A free radical scavenger.
SGTC_943 3253-1379 105 µM -2.07486630367044 0.0100696198287772 no 3299 0.0189994637251976 1055 668464
SGTC_1933 st074711 15.9 µM -2.07714058225721 0.0100017592338208 no 3300 0.0188942929763475 1064 17250958
SGTC_1917 st066507 28.5 µM -2.08256271892 0.00984158001998254 no 3301 0.0186455502010572 1039 3156428
SGTC_1056 3448-1962 115 µM -2.08850946495165 0.00966848320166886 no 3302 0.0183759512548502 1052 715507
SGTC_3050 9093513 49.47 µM -2.08875712444661 0.00966133244187066 no 3303 0.018364795876397 1046 25236664
SGTC_1457 k015-0032 57.3 µM -2.10690915488087 0.00914964764431234 no 3304 0.0175627274542122 1068 4302660
SGTC_250 brefeldin a 552.239 µM -2.12417205551334 0.00868519734977988 no 3305 0.016827879508914 1084 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_145 3737-0113 38.366 µM -2.13571467324614 0.00838630306197882 no 3306 0.0163513388316202 1065 6849351
SGTC_2112 5488546 200 µM -2.14805361454132 0.00807681076766713 no 3307 0.0158547482625111 1081 600757
SGTC_1108 betulinic acid 729.144 nM -2.15057354389217 0.00801485347771169 no 3308 0.0157549376876428 1071 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_1127 asiatic acid 681.4 nM -2.18331341883805 0.0072470549069687 no 3309 0.0145063685140986 1062 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_2996 9066192 71.4286 µM -2.20278065593745 0.00682193274347392 no 3310 0.0138051061088543 1060 6472854
SGTC_2725 haloperidol 53.21 µM -2.22098917444372 0.00644439405505717 no 3311 0.0131758473131863 1066 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1926 methyl fluorone black 53.6 µM -2.2236411919601 0.00639097757840876 no 3312 0.0130862973971817 1030 72721 Reacts with homocysteine.
SGTC_867 0518-0118 155 µM -2.23455521899205 0.00617525098528354 no 3313 0.012723281769603 1067 6848158
SGTC_1447 4239-0816 81.9 µM -2.23738954376741 0.00612029357265639 no 3314 0.0126304456695145 1073 1341554
SGTC_2400 5203494 178.7 µM -2.23887635338776 0.00609163805459514 no 3315 0.0125819812361012 1060 6777674
SGTC_948 3448-0295 75.3 µM -2.24244366961491 0.00602336889760977 no 3316 0.0124663560517707 1068 678569
SGTC_750 4073-0104 132 µM -2.27848892586853 0.00537069402043902 no 3317 0.0113487317775019 1019 22330957
SGTC_335 4077-0256 27.6 µM -2.28051560985737 0.00533593824419762 no 3318 0.0112885630269498 1062 3121989
SGTC_2842 9000675 19.48 µM -2.28134818795708 0.00532171834672759 no 3319 0.0112639256801233 1072 2989072
SGTC_719 2810-4230 27.3 µM -2.30709326676916 0.00489831672845722 no 3320 0.0105248106211541 1085 721079
SGTC_1397 3532-0190 20.1 µM -2.333068806099 0.00450181064611808 no 3321 0.00982226717348478 1084 5322280
SGTC_1925 st057770 10.1 µM -2.33478590654408 0.00447663910230055 no 3322 0.00977730390410908 1073 5989122
SGTC_1674 st016616 23.6 µM -2.34733693279666 0.00429643487302416 no 3323 0.0094540738523127 1068 625830
SGTC_2339 9000433 200 µM -2.39500846090641 0.00366962325745489 no 3324 0.00830999087551573 1076 2988954
SGTC_1784 st039334 36.3 µM -2.40445507561748 0.00355562669818466 no 3325 0.00809829840606644 1071 3496984
SGTC_2789 5281112 71.43 µM -2.42879951833693 0.00327636531392094 no 3326 0.0075744532633559 1076 765948
SGTC_318 1488-0629 67.2 µM -2.43616916539211 0.00319580497857272 no 3327 0.00742187042487225 1084 3662576
SGTC_560 2332-1943 155 µM -2.46307625153646 0.0029165883406807 no 3328 0.00688753084359969 1086 21177716
SGTC_1375 2910-0797 186 µM -2.476027460765 0.00279019935453246 no 3329 0.00664266796985591 1083 742508
SGTC_2017 5132927 60.65 µM -2.48118591732842 0.00274125040377221 no 3330 0.00654730271491163 1080 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -2.49384183055988 0.0026244247664117 no 3331 0.00631844206885338 1078 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_178 4092-0806 87.505 µM -2.50299333992251 0.00254277056191503 no 3332 0.00615739307206065 1060 2169044
SGTC_2009 4012297 12.05 µM -2.59310869901513 0.00185311272683584 no 3333 0.00475563520521847 1079 45595307
SGTC_1504 k297-0033 30 µM -2.63863548805345 0.00157375695029795 no 3334 0.00416202151720785 1069 4388117
SGTC_744 1594-0068 283 µM -2.64209929567729 0.00155416074826194 no 3335 0.0041196948125629 1085 668392
SGTC_631 k072-0230 41.5 µM -2.65151770096437 0.0015019965543744 no 3336 0.00400654563385813 1091 5773147
SGTC_954 1189-0853 2.85 µM -2.6776478632973 0.0013655261120555 no 3337 0.00370705598208562 1077 2828194
SGTC_1677 st019204 53.9 µM -2.67967054129236 0.00135544975278364 no 3338 0.00368473264558904 1091 3945625
SGTC_2417 cerulenin 830 nM -2.7040409474158 0.00123927123170093 no 3339 0.00342509235815605 1084 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_1460 k062-0059 9.15 µM -2.7102138066512 0.00121132731962328 no 3340 0.00336199243097418 1069 1373085
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -2.85893575791398 0.000689949687562124 yes 3341 0.00212532428553331 1091 2333 A French combination drug.
SGTC_2796 7949634 45.45 µM -2.89151456415682 0.000607823555263346 yes 3342 0.00191694911106939 1081 2971588
SGTC_157 1348-1695 65.819 µM -2.90551029601474 0.00057539692827226 yes 3343 0.0018332739297298 1079 5380510
SGTC_116 0155-0182 31.788 µM -3.02209409723688 0.000361218450008517 yes 3344 0.0012551625012958 991 771486
SGTC_396 dithiazanine 1.25 µM -3.04430186634321 0.000329967159793778 yes 3345 0.00116610498285866 1093 10578 An antihelmenthic.
SGTC_1389 3405-0187 19 µM -3.09233402573696 0.000270778105844597 yes 3346 0.000992946257221052 1090 799890
SGTC_2785 7756463 72.73 µM -3.10779455331957 0.00025393811440665 yes 3347 0.000942445245655435 1088 2201551
SGTC_2801 7907800 81.82 µM -3.15236306877204 0.000210697246063011 yes 3348 0.000809773808632522 1080 6620925
SGTC_3062 9077494 49.47 µM -3.23340352615109 0.000149158884781792 yes 3349 0.00061162321839576 972 16459633
SGTC_143 4032-1194 15.74 µM -3.26646368930386 0.000129267298395433 yes 3350 0.000544498863300309 1086 1806963
SGTC_1701 st028638 40.4 µM -3.3447162034209 9.16485623501367e-05 yes 3351 0.000411834021985358 1094 3490878
SGTC_2418 pentamidine 31.67 µM -3.61968912531879 2.58418597482088e-05 yes 3352 0.000147478582193974 1075 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_144 4161-2749 112.381 µM -4.35357076061643 5.66681260297081e-07 yes 3353 6.69689179791236e-06 1093 797501 YMR168C CEP3
SGTC_1107 amlodipine 47 µM -5.27303957498083 1.89462083666437e-09 yes 3354 6.70913070421818e-08 1086 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_1526 st051518 75 µM -5.82843755470028 3.68309215868726e-11 yes 3355 2.79743623276919e-09 1095 673993
SGTC_141 0443-0274 32.331 µM -6.27908142351367 1.14190008000433e-12 yes 3356 1.70289602173865e-10 1066 1627241