SGTCid condition conc unit PTA1|YAL043C.score PTA1|YAL043C.strain.pval PTA1|YAL043C.strain.significant PTA1|YAL043C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_773 4358-1457 44.6 µM 8.05457339460895 1.95108526466001e-21 yes 1 3.98782438930081e-16 4 1186886 SGTC_767 0929-0023 86 µM 4.50977382643968 6.78024388794114e-08 yes 2 3.24483890383151e-06 9 1204563 SGTC_163 TUB2.036 7.546 µM 3.81672303107805 4.15625690222699e-06 yes 3 6.7617915995376e-05 48 15992207 YJR013W GPI14 SGTC_122 0236-0016 402.397 µM 3.73712220359111 6.40091833391329e-06 yes 4 9.30692349327251e-05 17 6808838 SGTC_234 nsc-17383 10.7 µM 3.33778816369605 4.92282934526043e-05 yes 5 0.000422240525001515 9 408974 SGTC_3336 9143619 71.43 µM 3.16319930174251 0.000112447712949884 yes 6 0.000780227315628465 2 45595730 SGTC_18 0111-0177 500 nM 3.07012903299316 0.000171834552848815 yes 7 0.00106983154414508 12 721752 SGTC_2708 st078559 56 µM 2.95324599582968 0.000288033194488207 yes 8 0.00157225635441608 6 17250902 SGTC_1319 1306-0155 43.7 µM 2.8862965950418 0.000384116552998009 yes 9 0.00194902310754288 17 3122360 SGTC_826 1683-5028 118 µM 2.88319187975648 0.000389223848713637 yes 10 0.00196833781875408 11 722377 SGTC_3344 9148862 3.898 µM 2.84515300864159 0.000457131732804583 yes 11 0.00221950471341505 13 4905352 SGTC_1892 st058411 7.36 µM 2.7720483869194 0.000619415852281641 yes 12 0.00278523777762346 18 3934738 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 2.74989134893188 0.000678233748252445 yes 13 0.00298075140795235 21 1609 A potent and irreversible inhibitor of serine proteases. SGTC_1846 st056244 14.8 µM 2.73243973046809 0.0007281419780444 yes 14 0.00314335861830852 19 5393182 SGTC_2555 cholic acid 100 µM 2.6984722257687 0.000835115987759057 yes 15 0.00348292751434774 8 6708657 Influences liver metabolism. SGTC_457 grayanotoxin iii 135 µM 2.68398848269387 0.000884981720688347 yes 16 0.00363748061862188 38 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_1026 k007-1105 30.6 µM 2.64291486721426 0.00104165558644162 no 17 0.00410978496531106 42 7066794 SGTC_902 1120-0002 2.07 µM 2.64266044543872 0.00104270078978442 no 18 0.00411287410183018 34 3280475 SGTC_1861 st057647 17.4 µM 2.63769142891516 0.00106330809547148 no 19 0.00417362490703565 17 688668 SGTC_632 0781-2353 4.65 µM 2.60905393754375 0.00118952744180731 no 20 0.00453964650952122 42 6811515 YHR007C ERG11 SGTC_1223 0764-0573 147 µM 2.5875269531004 0.00129328109935956 no 21 0.00483338162897744 12 1609797 SGTC_2431 5490079 200 µM 2.58319313565087 0.00131514409012927 no 22 0.00489452532070496 37 5722345 SGTC_1345 1488-0192 31.4 µM 2.5566734326366 0.00145645166830293 no 23 0.00528391881816997 17 658348 SGTC_2711 st079103 59.1 µM 2.53561949045272 0.00157835634871579 no 24 0.00561243133002033 17 54693780 SGTC_409 arachidonic acid 100 µM 2.530318256797 0.00161048261449503 no 25 0.0056979553257976 18 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_807 1315-0151 48 µM 2.51623827654421 0.0016987232585417 no 26 0.00593074804018513 42 4011080 SGTC_797 k781-0471 270 µM 2.47418568596462 0.0019891090620055 no 27 0.00667701346511548 31 23738129 SGTC_7 0192-1582 4.227 µM 2.46473857788233 0.0020602513087314 no 28 0.00685566242553801 29 252616 SGTC_833 3852-0053 558 µM 2.46185767891283 0.00208240109419174 no 29 0.00691097509858298 32 3123681 SGTC_631 k072-0230 41.5 µM 2.45698499125734 0.00212035696250059 no 30 0.00700542700267942 24 5773147 SGTC_958 1222-0007 33 µM 2.39249782483926 0.00268527755457386 no 31 0.00836706364252214 38 7312461 SGTC_951 1171-0579 82.7 µM 2.38716891224101 0.00273755607050509 no 32 0.00848934416350794 59 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_183 3914-0051 30.55 µM 2.35083197827406 0.00311921087927081 no 33 0.00936574502331601 15 1596232 SGTC_967 1306-0166 352 µM 2.34671663177928 0.00316532493719606 no 34 0.00946982635183952 25 4437607 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 2.34353592152637 0.00320138542108489 no 35 0.00955096136024893 60 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1916 st067606 49.2 µM 2.33634105350922 0.00328432267650861 no 36 0.0097367367445033 48 19590279 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 2.32009933557995 0.0034786908454224 no 37 0.0101677521396479 26 756377 SGTC_1113 artemisinin 1.17947 µM 2.29237689413713 0.00383442927318844 no 38 0.0109419520760025 69 2240 An anti-malaria and mitochondrial poison. SGTC_622 1348-1566 26.3 µM 2.29030905354578 0.00386222747972651 no 39 0.0110017036815376 34 7340407 SGTC_762 1165-0429 115 µM 2.28386293683356 0.00395004599898793 no 40 0.0111897937217287 37 5967793 SGTC_3314 9135860 59.4275 µM 2.27947783108461 0.0040108042614062 no 41 0.0113193381615322 20 25252478 SGTC_2650 prasterone 100 µM 2.27003281057203 0.00414452115999534 no 42 0.0116027961859846 16 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_438 sphingosine 6.67 µM 2.26907091153835 0.00415836047823562 no 43 0.0116320069798056 15 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_149 3970-0822 46.1 µM 2.26191116788111 0.00426267708990172 no 44 0.0118514461192579 53 3114250 YBL034C STU1 SGTC_1416 3966-0321 25.3 µM 2.26126883257091 0.00427214925589945 no 45 0.0118713075029869 42 582530 YLR208W SEC13 SGTC_2398 5228213 48.84 µM 2.25462502619262 0.00437123137201048 no 46 0.0120784376166688 57 80771 YMR134W ERG29 SGTC_2288 7946289 167.31 µM 2.25297066424233 0.0043962207730104 no 47 0.0121304993530995 40 1246052 SGTC_139 0099-0334 718.624 µM 2.23536855650981 0.00467011390920145 no 48 0.0126965813192758 36 97690 SGTC_1494 4358-1428 177 µM 2.22276399941959 0.00487549559070207 no 49 0.013115858908302 31 1564571 SGTC_2863 9028737 58.44 µM 2.21936522575062 0.0049322365860396 no 50 0.0132309437158126 17 6460917 SGTC_1284 0929-0043 16 µM 2.21489242847936 0.00500780424827617 no 51 0.0133837244666239 41 1239883 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 2.20927810654031 0.0051041164295621 no 52 0.0135776515182438 40 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_1313 1220-0047 237 µM 2.17918759085402 0.00564894916987653 no 53 0.0146588676990883 51 3528706 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 2.1681542207058 0.00586130652459321 no 54 0.0150734773039076 40 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1913 st060213 96.1 µM 2.1599576511186 0.00602361868406001 no 55 0.0153879740509591 30 688959 SGTC_563 tetrahydrosecaminediol 614 µM 2.14817330025916 0.00626395834441833 no 56 0.0158499954571543 29 334274 A psychoactive constituent of the cannabis plant. SGTC_1192 1488-0095 21.4 µM 2.14219174893354 0.00638916956797946 no 57 0.0160890276011754 30 915875 SGTC_641 4092-0595 30 µM 2.13209599256939 0.00660553259113679 no 58 0.0164994780068738 59 786260 SGTC_3236 9132701 49.47 µM 2.11316491405327 0.00702876677175399 no 59 0.0172933275957336 39 24282524 SGTC_1242 0402-0103 60.1 µM 2.09441871962709 0.00747127311947608 no 60 0.0181113483204657 42 432868 SGTC_2756 carbadox 75.1 µM 2.09344341160301 0.0074949527174107 no 61 0.0181547952981321 78 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_3342 9147791 14.508 µM 2.09004941935816 0.00757787192316414 no 62 0.018306680307066 33 1838168 SGTC_991 3996-0057 64.7 µM 2.06717576416045 0.00815806996663206 no 63 0.0193587975132464 47 715343 SGTC_1491 4138-0063 26.5 µM 2.05809089631234 0.00839912624551912 no 64 0.019790704374346 37 23883227 SGTC_2268 7933382 153.85 µM 2.05149690194445 0.00857798478686803 no 65 0.0201092905131488 55 935025 YOR257W CDC31 SGTC_2084 5306078 60.6385 µM 2.03279583845642 0.00910353964206822 no 66 0.0210365768818978 45 679340 SGTC_2754 granisetron 64.02 µM 2.02820780300418 0.00923670563799412 no 67 0.0212695219319969 55 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_198 3454-2873 16.191 µM 2.02639691106863 0.00928973348833933 no 68 0.0213620636226982 46 710957 SGTC_2862 9027634 71.43 µM 2.02611969627028 0.0092978745593742 no 69 0.0213762600845921 49 5012562 SGTC_2123 5259487 200 µM 2.0231523394048 0.00938540984007838 no 70 0.0215287218723755 41 2173474 SGTC_2612 dictamnine 15.46 µM 2.02130666365555 0.00944021907970194 no 71 0.0216240148933724 89 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_1343 1487-0095 224 µM 2.01941084712715 0.00949680853257489 no 72 0.0217222675302153 44 4560101 YGL055W OLE1 SGTC_1001 4048-4355 44.4 µM 2.01470555533533 0.00963854321992394 no 73 0.0219677548932189 66 21824233 SGTC_3149 9097855 49.47 µM 2.00956655616929 0.00979545105748923 no 74 0.0222385419362299 46 25236625 YMR079W SEC14 SGTC_3355 9151058 44.0485 µM 2.00681294398417 0.00988044096600054 no 75 0.0223847920464005 46 17015728 SGTC_749 1000-0129 128 µM 1.97294120955595 0.0109797411788584 no 76 0.0242511304117965 47 708470 SGTC_296 1222-0039 74.9 µM 1.97089856202919 0.0110493113373339 no 77 0.024367739825259 43 5984176 SGTC_2292 7671323 168.05 µM 1.96933868656648 0.0111026967494059 no 78 0.0244571057386488 94 937504 SGTC_595 3909-8003 73.7 µM 1.9565639985756 0.0115484039446702 no 79 0.0251993756002888 57 699517 SGTC_511 blebbistatin 171 µM 1.95295773948124 0.0116770050414191 no 80 0.025412301500751 51 3476986 A myosin inhibitor. SGTC_2221 6807166 181.081 µM 1.94695188836525 0.0118939366629415 no 81 0.0257702514783721 31 674925 SGTC_2758 dehydroepiandrosterone 69.35 µM 1.94050742619827 0.012130590909538 no 82 0.0261590262746467 62 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_813 k007-0158 173 µM 1.9346050760144 0.0123509079374287 no 83 0.0265193883310614 49 6523916 SGTC_1230 0170-0365 3.77 µM 1.93437411274274 0.0123595991234334 no 84 0.0265335734744718 74 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_1161 k007-0610 110 µM 1.93383988472268 0.0123797225131392 no 85 0.0265664086153397 93 5843850 SGTC_829 1635-0120 117 µM 1.93040476163401 0.0125097964603993 no 86 0.0267783527051117 102 285054 SGTC_803 4488-1585 147 µM 1.93029979031115 0.0125137898542843 no 87 0.0267848515126901 50 747204 SGTC_2435 5706476 10.6 µM 1.92940075571716 0.0125480367988187 no 88 0.0268405649874669 46 5725375 SGTC_1237 0330-0133 46.1 µM 1.92384308952297 0.012761551507423 no 89 0.027187127249344 70 X1237 YHR072W ERG7 SGTC_643 k048-0106 28.4 µM 1.92257871862558 0.0128105627413894 no 90 0.0272664893965331 69 6763920 SGTC_3093 9117344 49.47 µM 1.90105218677917 0.0136703307957089 no 91 0.0286475887008656 56 24824913 SGTC_2363 9053361 176 µM 1.8977329907669 0.0138072343425911 no 92 0.0288656321668805 65 6469797 YMR079W SEC14 SGTC_1041 0206-0046 107 µM 1.8936974665635 0.0139752749842991 no 93 0.0291325889005454 60 50494 SGTC_568 1193-0097 7.48 µM 1.88800558374551 0.0142152823198016 no 94 0.0295126004212747 89 3646150 SGTC_481 bay k-8644 50 µM 1.88492984208944 0.0143464475551443 no 95 0.0297196552434392 51 2303 A calcium channel antagonist. SGTC_1679 SEC14.276 6.7 µM 1.86772816748769 0.0150993879347426 no 96 0.0308999851902919 92 1005053 YMR079W SEC14 SGTC_1202 1988-0068 29.6 µM 1.86771039240411 0.0151001832081778 no 97 0.0309012246449489 56 2850480 SGTC_512 prima-1 270 µM 1.86535726653223 0.0152057824770078 no 98 0.0310656715336643 44 322968 A re-activator of the apoptotic function of mutant p53. SGTC_1567 st069303 68.4 µM 1.85655316017401 0.015606522764605 no 99 0.0316873765886385 77 5581319 SGTC_3354 9151612 71.43 µM 1.85543978725908 0.0156578404627813 no 100 0.0317667250841665 54 27261949 SGTC_798 1287-0182 476 µM 1.85387945941561 0.0157300028360361 no 101 0.0318782035888615 59 1649755 SGTC_330 1488-0319 80.1 µM 1.84675543319057 0.0160631120447211 no 102 0.0323912968332493 75 6846614 SGTC_1266 0828-0227 32.9 µM 1.83831241276622 0.0164657069083611 no 103 0.0330081915335045 71 3913820 SGTC_2174 5790901 200 µM 1.83230710891006 0.0167572923307441 no 104 0.033452839285543 77 786020 SGTC_83 0170-0301 39.027 µM 1.82695681257702 0.0170207837017583 no 105 0.0338531315488698 29 3089716 SGTC_1291 0993-0025 5.79 µM 1.81559894243227 0.0175918943124836 no 106 0.0347159579857471 58 4353356 SGTC_3013 9080133 71.4286 µM 1.8136078248818 0.0176936809499342 no 107 0.0348690624511455 57 17050193 SGTC_1002 4049-0206 172 µM 1.80719318552018 0.0180250238156806 no 108 0.0353660815404749 72 4662749 SGTC_619 1652-1634 108 µM 1.80467795803889 0.018156382119446 no 109 0.0355625454890073 51 5400454 SGTC_2791 5663188 71.43 µM 1.8027436132592 0.0182579579017302 no 110 0.0357142446646091 87 54690634 SGTC_1101 ebselen 5.29 µM 1.79803335092194 0.0185073288707083 no 111 0.0360858614137648 83 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_1982 st072467 71.9 µM 1.79663211889024 0.018582070406188 no 112 0.036197020937519 80 3163533 SGTC_2094 5332512 191.667 µM 1.79097570853966 0.0188864004654573 no 113 0.0366485966000574 59 755774 SGTC_304 1310-0298 97 µM 1.78835322925487 0.0190289292890704 no 114 0.0368595185339883 79 1550234 SGTC_764 1951-2361 146 µM 1.77117398278978 0.0199854046568644 no 115 0.0382658871439346 92 5438930 SGTC_2970 9090938 41.86 µM 1.76788231465738 0.0201732540208942 no 116 0.0385402899825992 81 17217104 SGTC_91 0417-1751 58.384 µM 1.75582819783836 0.0208739910138977 no 117 0.0395588740359779 81 6795624 SGTC_2220 6782180 200 µM 1.75156444153083 0.021126738167988 no 118 0.0399243656960781 30 833803 SGTC_2415 st077333 57.7 µM 1.75052650915366 0.0211886551247482 no 119 0.0400137519888342 107 2766255 SGTC_2628 lathosterol 100 µM 1.7453628230301 0.0214989763320103 no 120 0.0404608663667199 72 6710616 SGTC_1174 0739-0097 51.1 µM 1.74397444696271 0.021583065681363 no 121 0.0405817728467287 68 728447 SGTC_658 3253-0951 102 µM 1.73773699230049 0.0219642849058863 no 122 0.0411285836772074 88 1184878 SGTC_1757 st041620 31.8375 µM 1.73663819088654 0.0220320267329108 no 123 0.0412255269940397 53 5289815 SGTC_404 fumagillin 50 µM 1.72820629571586 0.0225577509639653 no 124 0.0419756227096139 72 12015870 A methionine aminopeptidase binder. SGTC_2986 9022445 71.43 µM 1.72696155077698 0.0226362489752905 no 125 0.0420872844815207 71 6459286 SGTC_608 k048-0125 159 µM 1.71885833677227 0.0231529147055826 no 126 0.0428200850342938 65 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_249 wiskostatin 11.211 µM 1.71548122527283 0.0233711540134979 no 127 0.0431285173439202 57 2775510 A n-wasp and actin depolymerizer. SGTC_1424 4048-1941 275 µM 1.71432014044075 0.0234465856655721 no 128 0.0432349730982932 68 X1424 SGTC_858 0438-0351 2.77 µM 1.71111745934858 0.0236557152295331 no 129 0.0435297158738293 79 2799119 SGTC_2879 9041815 71.43 µM 1.70958332969388 0.023756445604721 no 130 0.0436714752262353 36 4942971 SGTC_634 1611-4317 11.2 µM 1.69553531418998 0.0246957138433994 no 131 0.0449869584877607 85 2843522 SGTC_2646 retinol 96.75 µM 1.69141941790788 0.0249767388407797 no 132 0.045378363119438 82 445354 A vitamin A analog and teratogen. SGTC_2108 5365811 200 µM 1.682365490908 0.025604367684174 no 133 0.0462489944008954 80 780283 SGTC_19 0279-0214 38.434 µM 1.67738852887563 0.0259549650598255 no 134 0.0467332655199765 80 3566274 YBR002C RER2 SGTC_1258 0671-0043 57.1 µM 1.67729368858433 0.0259616847958777 no 135 0.0467425330713804 79 4298767 SGTC_2807 7945238 51.95 µM 1.67598753530885 0.026054378047599 no 136 0.0468703170779901 74 17148797 SGTC_2103 5378138 10 µM 1.67012262008848 0.0264740097642077 no 137 0.0474475527949076 62 244142 SGTC_3205 9113483 49.47 µM 1.66449354854641 0.0268820637669214 no 138 0.0480069196273361 70 17018033 SGTC_2402 5553605 200 µM 1.65964206489477 0.0272379505115865 no 139 0.0484932403565495 81 6758546 SGTC_517 1365-0151 113 µM 1.65515927879842 0.0275702763174785 no 140 0.0489460964790448 77 768657 SGTC_1837 st055472 66.5 µM 1.64692441651394 0.0281895652976011 no 141 0.0497867912610528 67 676091 SGTC_2038 4100038 30.985 µM 1.64390625255838 0.0284194221549217 no 142 0.0500977842184905 94 3596803 SGTC_2717 st081029 62.2815 µM 1.64328991043698 0.0284665526805704 no 143 0.0501614824225353 70 5292846 SGTC_326 k292-0812 17.5 µM 1.64062736070981 0.0286709007064677 no 144 0.0504373959123872 75 3579357 SGTC_2021 4019055 173 µM 1.63954046872205 0.0287546684920755 no 145 0.0505503748536936 134 44827708 YER133W GLC7 SGTC_450 aminopyrene 156 nM 1.63405050458166 0.029180900865255 no 146 0.0511241231807433 83 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_444 curcumin 90.4 µM 1.63375749847734 0.0292037961634719 no 147 0.051154889906466 96 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_576 1073-0113 22.7 µM 1.63161147900401 0.0293719399252001 no 148 0.0513806792517158 125 5439563 SGTC_1967 st070177 51.4 µM 1.62973580419659 0.0295195594024452 no 149 0.0515786733489379 85 5729214 SGTC_1355 1499-0035 1.68 µM 1.62920703638342 0.029561285626169 no 150 0.0516345989553329 78 1548538 SGTC_464 bw-b 70c 158 µM 1.62456304903954 0.0299298599760123 no 151 0.0521278479432494 88 5353454 SGTC_2445 5742597 35.57 µM 1.61787657362246 0.0304672256817242 no 152 0.0528445998984866 95 1774255 SGTC_2504 purpurogallin 52.29 µM 1.61510112319213 0.0306926130654744 no 153 0.0531443988883377 72 5281571 An antioxidant. SGTC_2269 7935389 174.42 µM 1.61475376353692 0.0307209182354656 no 154 0.0531820147895186 90 97605 SGTC_2567 aureobasidin a 60 nM 1.60526781498138 0.0315022892748609 no 155 0.0542174394780309 149 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_1330 1469-0054 61.8 µM 1.60429952733759 0.0315829644549407 no 156 0.0543240226255626 87 7102664 SGTC_1909 st060837 51.5 µM 1.59998799741975 0.0319442653980672 no 157 0.054800623048561 86 678937 SGTC_1360 1598-0022 39.8 µM 1.59301771583032 0.0325355819506214 no 158 0.0555781084127678 104 761525 SGTC_2393 9031399 185.94 µM 1.5911139248678 0.0326986487381814 no 159 0.0557919696394293 97 1526623 YDL150W RPC53 SGTC_2595 hexamethylquercetagetin 100 µM 1.58803559323773 0.0329637447381029 no 160 0.0561391453988332 95 386331 SGTC_1453 4237-0541 195 µM 1.58037459509649 0.0336311812129771 no 161 0.057010552992864 92 739892 SGTC_1404 3909-7820 48.3 µM 1.57873816900729 0.0337751809655655 no 162 0.057198063030969 83 23741373 SGTC_584 0986-0246 15.4 µM 1.57466387118537 0.0341359097196696 no 163 0.0576670256859623 126 53315 YDR232W HEM1 SGTC_2114 5491910 81.25 µM 1.57295557629314 0.0342880977103921 no 164 0.057864552459246 90 2849228 SGTC_1435 4092-0789 56.7 µM 1.56633364531421 0.034883309287569 no 165 0.0586352641288131 104 2248285 SGTC_1371 2421-0008 32.7 µM 1.56504623147804 0.0350000075261446 no 166 0.0587860347749506 115 2827552 SGTC_2200 6600604 21.907 µM 1.5592961676541 0.0355251424187909 no 167 0.059463149186353 97 2904777 SGTC_1983 st071813 46.9 µM 1.55674947801221 0.0357597786629195 no 168 0.0597649882306639 87 11838595 SGTC_1755 st041960 45.185 µM 1.55301181879067 0.0361064417310989 no 169 0.0602101555430877 108 2257073 SGTC_159 3970-0959 50 µM 1.55262345513318 0.0361426192557523 no 170 0.0602565593885015 123 6615653 SGTC_3338 9144300 39.5675 µM 1.54853207936659 0.0365255525505823 no 171 0.0607471221896791 67 4901274 SGTC_2550 chrysin dimethyl ether 71.87 µM 1.54488912654452 0.0368693034382865 no 172 0.0611865419977154 52 88881 An O-methylated flavonoid and antioxidant. SGTC_3234 9132280 49.47 µM 1.53336095468228 0.037974573885338 no 173 0.0625934717765716 91 17612295 SGTC_2237 6667747 47.222 µM 1.53011100252008 0.0382910038456797 no 174 0.0629946276489986 78 729940 YDL015C TSC13 SGTC_2008 4012253 172 µM 1.5232034200822 0.0389706991460524 no 175 0.0638539103590909 99 603940 SGTC_3176 9106582 49.47 µM 1.52107068541118 0.0391825308515383 no 176 0.0641210499758778 40 17018027 SGTC_1882 5615643 20 µM 1.51994870296883 0.0392943462661868 no 177 0.06426193429304 82 2253075 SGTC_2861 9024595 19.48 µM 1.51643684178474 0.0396460134184451 no 178 0.0647044645848273 50 16482810 SGTC_1211 1056-0033 32.3 µM 1.51540888507908 0.0397494327386508 no 179 0.0648344443505448 86 6741922 SGTC_863 0466-0191 129 µM 1.51159386793827 0.04013516803132 no 180 0.0653186063100767 116 765160 YPR165W RHO1 SGTC_734 2023-0417 80 µM 1.50937317150394 0.0403610987456365 no 181 0.0656017225721375 112 3935732 SGTC_269 exalamide 29 µM 1.50668212170238 0.0406362655124909 no 182 0.0659460781627298 102 3316 A derivative of salicylamide. SGTC_884 0851-0618 334 µM 1.50619757817935 0.040685972723602 no 183 0.0660082304877191 97 9642473 SGTC_2543 pimpinellin 60.67 µM 1.50330670065095 0.0409835615812624 no 184 0.0663799865098288 92 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_1530 rhein 70.4 µM 1.4978681134261 0.04154819716855 no 185 0.0670837598407726 98 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_2770 toltrazuril 17.5 µM 1.49657693208745 0.0416831695903636 no 186 0.0672516880826403 77 68591 Kills coccidiodes. SGTC_3299 9121982 43.1275 µM 1.49528842597478 0.0418182161929169 no 187 0.067419592191597 81 17594604 YPL160W CDC60 SGTC_23 0213-0011 39.996 µM 1.49345227585262 0.042011272588616 no 188 0.0676594188968054 104 627608 SGTC_1340 1486-1359 257 µM 1.49134642282925 0.042233573592819 no 189 0.067935283364324 102 4309068 SGTC_2707 st078556 66.6 µM 1.49103641601084 0.0422663791908645 no 190 0.0679759671586411 81 17250899 SGTC_420 mitomycin C 81.9 mM 1.49023544008191 0.0423512356706583 no 191 0.0680811704577121 109 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2765 myclobutanil 7.74 µM 1.48833303134023 0.0425533318854193 no 192 0.0683315440080742 111 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_1381 2324-0066 62.1 µM 1.48781576912494 0.0426084161956622 no 193 0.0683997429262497 110 10885928 SGTC_2716 st080858 38.6235 µM 1.48663294781823 0.0427345939194689 no 194 0.0685558904449053 79 5296050 SGTC_2780 5215298 71.43 µM 1.48224234704689 0.0432056060101007 no 195 0.0691379112621948 123 2834131 SGTC_206 4546-0025 72.014 µM 1.47474401004103 0.0440196952614041 no 196 0.0701406895836014 102 6620745 YIL048W NEO1 SGTC_1031 k035-0009 16 µM 1.47038201670871 0.0444989361353564 no 197 0.0707291595534609 103 5180959 SGTC_103 0844-0104 51.839 µM 1.46854147280099 0.0447024088952322 no 198 0.07097859973416 167 5375804 SGTC_1499 4480-0877 67.3 µM 1.46712603480929 0.0448593951787544 no 199 0.0711708865126675 85 2861909 SGTC_933 2914-0560 114 µM 1.46417617248504 0.0451879909214099 no 200 0.071572909424966 95 463887 SGTC_822 1487-0950 154 µM 1.46257231665309 0.0453674612798766 no 201 0.0717922214315173 81 1958375 SGTC_1415 3966-0071 78.1 µM 1.46086133523506 0.045559550496136 no 202 0.0720267496650144 98 2893185 SGTC_2327 6189656 200 µM 1.45809463874249 0.0458715463522564 no 203 0.0724072294755259 97 5349088 SGTC_939 1165-0479 45.3 µM 1.45681731648667 0.0460161660542295 no 204 0.0725834072835438 95 1377347 SGTC_1527 coumarin 137 µM 1.45106331959451 0.0466721866291842 no 205 0.0733811146195148 110 323 A hepatotoxic, DNA x-linker. SGTC_3291 9121177 71.43 µM 1.44944106356224 0.046858492021299 no 206 0.0736072240188787 83 17015612 SGTC_2322 7413319 38.22 µM 1.44934956493508 0.0468690177796983 no 207 0.0736199929127534 127 1840400 SGTC_2476 5806916 10.51 µM 1.44718208277376 0.0471189141654449 no 208 0.0739229666760254 91 2870194 SGTC_1459 k035-0031 35.7 µM 1.44631987989404 0.0472186169572062 no 209 0.0740437511682862 84 3877128 YMR208W ERG12 SGTC_2289 7946404 165.07 µM 1.44485723265025 0.0473881401872951 no 210 0.0742489956126836 129 1246120 YPR165W RHO1 SGTC_2125 5246583 200 µM 1.44339964035554 0.047557562349904 no 211 0.0744539626827748 118 835267 SGTC_309 k408-0051 1.48 µM 1.44226001197181 0.047690363910171 no 212 0.0746145182475705 142 3640463 SGTC_1922 5578187 25 µM 1.43925387440465 0.0480420961137224 no 213 0.0750393031465057 108 1350412 SGTC_3142 9086498 49.47 µM 1.43617533372814 0.0484044484685147 no 214 0.0754762279929204 148 25236367 SGTC_3073 9114972 49.47 µM 1.43496659584028 0.0485473163336245 no 215 0.0756483083500357 81 41905075 SGTC_185 k048-0037 25.491 µM 1.43453488855508 0.0485984240049508 no 216 0.0757098401680399 81 6827589 SGTC_192 3455-0609 60.9 µM 1.42675920286712 0.0495263341345884 no 217 0.0768246571666452 100 3769639 SGTC_1862 st057513 3.81 µM 1.42202580429353 0.0500980822125036 no 218 0.0775093800202832 111 5393163 SGTC_2137 5261020 140 µM 1.41782723189639 0.0506096214035467 no 219 0.0781206057877883 100 763655 SGTC_1988 st071872 53.4 µM 1.4168769547366 0.0507259752417014 no 220 0.0782594526639745 86 16414116 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 1.41534135732107 0.0509144470183999 no 221 0.0784842172959946 73 4000243 SGTC_971 1315-0384 26.7 µM 1.41491604142232 0.0509667466936155 no 222 0.0785465570320539 114 6769120 SGTC_766 1391-0721 126 µM 1.41249752694009 0.0512649567849522 no 223 0.0789017591787388 117 1020919 YIL115C NUP159 SGTC_968 1309-0633 340 µM 1.41089820066542 0.0514629198509871 no 224 0.0791373164053706 110 3761976 SGTC_2219 9098279 200 µM 1.41072846773501 0.0514839648651182 no 225 0.0791623467917047 63 902349 SGTC_3219 9131112 49.47 µM 1.40969078161888 0.0516127753776246 no 226 0.079315503945534 114 17612988 YMR079W SEC14 SGTC_1418 3966-3099 2.4 µM 1.40622176936171 0.0520452532803405 no 227 0.0798291409006124 130 740335 SGTC_2536 dehydroabietamide 32.04 µM 1.40252014342761 0.0525099006610221 no 228 0.0803799898177857 88 3983547 SGTC_2703 st077852 53.4 µM 1.40143586018485 0.0526466272753974 no 229 0.0805418875409314 122 6281836 SGTC_519 k048-0011 62.8 µM 1.39920662871697 0.0529286177086908 no 230 0.0808755146881553 103 6836379 SGTC_1654 st012436 41.8 µM 1.39490545954085 0.0534760860757153 no 231 0.0815221752813504 79 4323132 SGTC_2544 sphondin 68.51 µM 1.39376745609317 0.0536216833724439 no 232 0.0816939192963307 130 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_127 0180-0333 59.125 µM 1.39059804329035 0.0540288367174556 no 233 0.0821736750218536 80 771601 SGTC_3235 9132602 49.47 µM 1.38085516952591 0.0552957771356759 no 234 0.08366174820052 127 4912240 SGTC_352 k048-0007 5.11 µM 1.38021151652717 0.0553802955990655 no 235 0.0837607645602098 149 6811911 SGTC_3177 9107506 49.47 µM 1.37708997703383 0.0557916346928086 no 236 0.0842422155685818 91 8897194 SGTC_3186 9110464 49.47 µM 1.37706005396961 0.0557955894211438 no 237 0.0842468407853079 89 17018021 SGTC_1305 1181-0477 144 µM 1.36831007919947 0.0569615341559935 no 238 0.0856075185861877 120 6252086 SGTC_384 k007-0144 5.16 µM 1.36505289413969 0.0574004262793576 no 239 0.0861182129667372 122 6824886 SGTC_1151 3909-8316 15.3 µM 1.35958389781403 0.0581433298758566 no 240 0.0869808182585848 111 800431 SGTC_3347 9188721 44.724 µM 1.35473836379072 0.0588078359495655 no 241 0.0877504651774157 131 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_1332 1480-0653 17.5 µM 1.35304127466927 0.0590419752839705 no 242 0.0880212223904251 114 5749438 SGTC_1561 5-methoxyflavone 52.9 µM 1.35171623890245 0.059225292048904 no 243 0.0882330540940143 106 94525 SGTC_2852 9023854 51.95 µM 1.34964818991085 0.0595122951952034 no 244 0.0885644293102711 143 19798528 SGTC_1968 st069590 43.6 µM 1.34846312683617 0.0596772484926255 no 245 0.0887547360537683 131 6384066 SGTC_262 fenpropimorph 62.5 µM 1.34537326347464 0.0601090228829928 no 246 0.0892523624702521 122 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_3202 9113761 49.47 µM 1.34504211699385 0.0601554417024752 no 247 0.0893058169487866 129 4798415 SGTC_2585 alliin 100 µM 1.34461926621195 0.0602147560648622 no 248 0.0893741091812687 106 87310 A garlic compound which reacts with lipids. SGTC_770 0389-1121 67.2 µM 1.34345804134066 0.0603778795628294 no 249 0.089561851844248 115 6753108 SGTC_1472 k841-0093 193 µM 1.34297283237406 0.0604461418292438 no 250 0.0896403855006509 108 X1472 SGTC_620 0109-0052 432 µM 1.34155262522673 0.0606462926516336 no 251 0.0898705478521432 127 493037 SGTC_3323 9138564 53.9225 µM 1.34004711760112 0.0608590305854988 no 252 0.0901150135019893 122 43912313 YNL103W MET4 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 1.33937851962989 0.0609536946996227 no 253 0.0902237393114021 92 4174840 SGTC_2130 NSC 7 2.4545 µM 1.33322145769484 0.061830868240738 no 254 0.0912295698262379 120 21448 SGTC_1976 st070609 63.5 µM 1.32718731445775 0.062700059674081 no 255 0.0922233638220775 119 682556 SGTC_3231 9132313 49.47 µM 1.32636637771438 0.0628190442701952 no 256 0.0923591849992371 116 4905967 SGTC_3341 9147222 25.867 µM 1.3261137150724 0.0628556999710734 no 257 0.0924010169452565 131 1939759 SGTC_556 4058-0063 51.5 µM 1.32349258841394 0.0632369507204128 no 258 0.09283580970977 122 6615692 SGTC_1220 1838-0075 193 µM 1.32179799121355 0.0634843917167919 no 259 0.0931177137208674 108 5529645 SGTC_1460 k062-0059 9.15 µM 1.3209974152554 0.0636015516678299 no 260 0.0932511130304573 117 1373085 SGTC_2802 7925815 54.55 µM 1.31997631976796 0.0637512275131122 no 261 0.093421462163139 123 1262923 SGTC_1270 0831-1170 17.3 µM 1.31397294950947 0.0646367708389792 no 262 0.0944276537490517 132 6764716 SGTC_2347 9049783 174.81 µM 1.31110594376349 0.0650630330820261 no 263 0.0949109864724942 129 6467988 YPL169C MEX67 SGTC_3018 9082602 49.47 µM 1.3105532390692 0.0651454586850704 no 264 0.0950043731054845 133 17332089 SGTC_2815 7968870 71.43 µM 1.30908546167759 0.0653647436535494 no 265 0.0952527016691498 121 2977326 YHR190W ERG9 SGTC_1849 st056239 19.2 µM 1.30711473994299 0.0656600681103285 no 266 0.0955868729780489 114 5393181 SGTC_422 cantharidin 155 µM 1.30580705418706 0.0658566029084393 no 267 0.0958090902786725 124 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1399 3562-5772 25 µM 1.30445359954552 0.0660604962284994 no 268 0.096039485118491 117 23847490 SGTC_2433 5607874 27.82 µM 1.2999046548312 0.0667493646309873 no 269 0.0968168247655732 107 2252428 SGTC_2045 5106652 78.05 µM 1.2987659622404 0.0669226691288289 no 270 0.0970121295655532 104 673349 SGTC_2602 kawain 100 µM 1.2986678665598 0.0669376151718411 no 271 0.0970289681339008 131 5369129 SGTC_1263 0774-1208 64.8 µM 1.29700206028193 0.0671918149573361 no 272 0.0973152389539338 150 906585 SGTC_2176 5809774 33.9695 µM 1.29629583030868 0.0672998097319724 no 273 0.0974367922919992 99 2870539 SGTC_577 r071-0003 38.6 µM 1.29501118592104 0.0674965980464507 no 274 0.0976581853632926 131 4568517 YMR134W ERG29 SGTC_600 1495-0418 41.6 µM 1.29479262806828 0.0675301220594584 no 275 0.0976958878761253 148 5377768 SGTC_1204 4049-0315 18.3 µM 1.29440308115448 0.0675899055355859 no 276 0.097763113465732 118 588402 SGTC_15 0266-0086 27.098 µM 1.29438090703841 0.0675933098104839 no 277 0.0977669411569849 143 1712902 YIL048W NEO1 SGTC_2688 kanamycin b 96.69 µM 1.29245083440913 0.0678901315912519 no 278 0.098100530984469 155 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_133 0724-0033 378.92 µM 1.28920013067918 0.0683923244373648 no 279 0.0986642598105858 128 280309 SGTC_2522 biochanin a 4.94 µM 1.28553030782 0.0689627049380351 no 280 0.099303516388654 116 5280373 A possible chelator. SGTC_1541 2',3',6-trimethoxyflavone 64 µM 1.28517538469001 0.0690180625780629 no 281 0.0993655016558729 138 688801 SGTC_2866 9034245 58.44 µM 1.27851498990951 0.0700632527566568 no 282 0.10053395140862 101 6462273 SGTC_1338 1486-1223 76 µM 1.27844911019911 0.0700736514876771 no 283 0.100545558703857 137 3444526 SGTC_1489 4065-0444 182 µM 1.27768004142196 0.0701951323923419 no 284 0.100681132668386 124 2877968 SGTC_802 4112-3352 742 µM 1.27366588400558 0.0708318332097576 no 285 0.101390926024191 121 704594 SGTC_219 mitoxanthrone 164.414 µM 1.27347803266326 0.0708617373477957 no 286 0.101424231426619 134 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_1191 1487-1166 10.6 µM 1.27331605514774 0.0708875304063031 no 287 0.101452955885459 107 3955771 SGTC_3230 9131665 49.47 µM 1.27236973279884 0.0710383655454201 no 288 0.101620891428591 88 15943720 SGTC_2860 9025725 38.96 µM 1.27175017267549 0.0711372512061497 no 289 0.101730948929281 135 40546248 SGTC_1587 estradiol valerate 56.1 µM 1.26721394085948 0.0718644849167893 no 290 0.102539401161152 147 13791 A steroid. SGTC_1447 4239-0816 81.9 µM 1.26555959714612 0.0721311180260601 no 291 0.102835399390577 144 1341554 SGTC_668 1682-0499 62.6 µM 1.26465669541476 0.07227695960286 no 292 0.102997209890854 129 682214 SGTC_1306 1185-0270 9.02 µM 1.26431864600644 0.0723316212776283 no 293 0.103057839841025 136 1548076 SGTC_1079 idarubicin 2.36 µM 1.26163385570867 0.0727668700164098 no 294 0.103540283933195 145 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_3001 9076041 71.4286 µM 1.26067559165522 0.0729227050901792 no 295 0.10371287572835 114 16004211 SGTC_176 1486-1328 72.834 µM 1.25363577657605 0.0740753781277887 no 296 0.104987210584434 144 22310231 SGTC_1877 wortmannin 25 µM 1.25169132068306 0.07439619650022 no 297 0.105341181957851 134 312145 A covalent inhibitor of PI 3-kinase. SGTC_2505 galangin 7.89 µM 1.25128021841928 0.0744641604660389 no 298 0.10541613000401 150 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_71 0417-1750 47.813 µM 1.25044796863899 0.0746018941850153 no 299 0.105567975511415 130 6811472 SGTC_1117 retinoic acid 1.10837 µM 1.24914942347295 0.0748171860210382 no 300 0.105805213291503 118 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_2667 digitoxin 100 µM 1.24853539678805 0.0749191532791218 no 301 0.105917527028781 93 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_1715 st032160 10.2275 µM 1.2454331252366 0.0754359479595593 no 302 0.10648629166071 120 5289825 SGTC_3183 9108214 49.47 µM 1.24298318847265 0.0758459893558156 no 303 0.106937014285492 72 4974831 SGTC_2890 9046729 58.44 µM 1.23826899802702 0.076639767191345 no 304 0.107808167525507 144 903329 SGTC_350 k064-0020 19.8 µM 1.23820895084187 0.0766499185623723 no 305 0.10781929674749 135 2790705 SGTC_729 4092-0585 94.1 µM 1.23664653882408 0.076914414183048 no 306 0.108109167134115 123 2169061 SGTC_1282 0886-0010 32.4 µM 1.23637895674082 0.0769597817811482 no 307 0.108158867184816 154 2836211 YNL267W PIK1 SGTC_2443 5493264 126.67 µM 1.23602154949309 0.0770204106437183 no 308 0.108225276797695 129 5340055 SGTC_3152 9099253 49.47 µM 1.23531018114278 0.0771411918021843 no 309 0.108357543027224 169 25236131 SGTC_1251 0490-5699 265 µM 1.23332486772375 0.0774790336893446 no 310 0.108727291788562 135 3883818 SGTC_987 1497-1013 404 µM 1.23106561436184 0.0778648576388033 no 311 0.109149162412148 135 1676435 SGTC_1524 corynanthine 62.1 µM 1.23085584674604 0.0779007545435425 no 312 0.109188391936448 133 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_666 0272-0154 136 µM 1.23032751406113 0.0779912221826879 no 313 0.109287242544532 157 6870312 SGTC_2914 7968218 45.32 µM 1.22960752151234 0.0781146364948885 no 314 0.109422056038019 98 2977111 SGTC_2436 5633522 8.09 µM 1.22813276930488 0.0783678869793212 no 315 0.109698565725267 139 5724242 SGTC_351 caspofungin 25 nM 1.22745935780332 0.0784837347912903 no 316 0.109824994167739 156 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_3225 9130819 49.47 µM 1.22668055132506 0.0786178756714695 no 317 0.109971340175579 142 4547121 SGTC_150 3970-0969 77.2 µM 1.225680019444 0.078790461245728 no 318 0.110159556028926 183 6615640 SGTC_1058 3448-5425 97.3 µM 1.22437035905271 0.0790168031891468 no 319 0.110406272869538 150 7279705 SGTC_879 0831-1030 162 µM 1.22266801128619 0.0793117469530137 no 320 0.110727556894533 170 1549252 SGTC_2321 7390090 138.78 µM 1.22053827769695 0.0796819109148069 no 321 0.111130444091272 111 649046 SGTC_265 mycophenolic acid 32.932 µM 1.21748303584349 0.0802152155977263 no 322 0.111710243501949 127 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_399 oxolinic acid 75 µM 1.21315231827978 0.0809757759357492 no 323 0.112535795158791 128 4628 A DNA gyrase inhibitor. SGTC_2073 5212005 126 µM 1.21205106096639 0.0811700439686026 no 324 0.112746417753222 147 691789 SGTC_2129 girgensonine 121.053 µM 1.20853096159442 0.0817933682001565 no 325 0.113421546926001 170 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_945 3381-0768 11.3 µM 1.20684347810254 0.0820934569252075 no 326 0.113746214221171 140 1126236 YIL048W NEO1 SGTC_4 0960-0234 25.671 µM 1.202569589095 0.0828572012733485 no 327 0.11457146091178 134 6821112 SGTC_3112 9123419 49.47 µM 1.20228553621897 0.0829081503682116 no 328 0.114626459408397 153 17015854 SGTC_1863 st057641 20.1 µM 1.19950840227673 0.0834075127329093 no 329 0.115165159803091 149 3921635 SGTC_2324 6149169 200 µM 1.19847547628957 0.0835938210211039 no 330 0.115365982310278 144 2888231 SGTC_1012 4112-3522 18 µM 1.1981022904 0.0836612091929273 no 331 0.115438598653105 136 3112398 SGTC_1972 st070201 17.4 µM 1.19700986130853 0.0838587095585057 no 332 0.115651355559839 139 2829099 SGTC_1257 0669-0121 16 µM 1.19478618470681 0.0842618097845347 no 333 0.116085289689066 145 4307855 SGTC_371 0195-0006 7.36 µM 1.19411093638642 0.084384503802151 no 334 0.11621728789067 132 3928593 SGTC_3094 9117742 49.47 µM 1.19273031781282 0.084635782227172 no 335 0.116487503994484 177 17149698 SGTC_1762 st045503 25.4615 µM 1.19150061104001 0.0848600662427632 no 336 0.116728558453004 123 4645554 SGTC_2175 5807670 165.306 µM 1.18764472969434 0.0855662227690938 no 337 0.117486703740019 106 241186 SGTC_1479 0549-0158 134 µM 1.18563275264028 0.085936433832647 no 338 0.117883680964995 141 5440202 SGTC_2384 9036245 200 µM 1.17984435345355 0.0870082040665727 no 339 0.119031062655398 111 6462766 SGTC_1851 st056236 18.9 µM 1.17941240836714 0.0870885808337014 no 340 0.119116998272428 144 5393171 SGTC_1283 0922-0125 16.4 µM 1.17890387899173 0.0871832795384937 no 341 0.11921822648412 130 3360884 SGTC_3289 9119912 71.43 µM 1.17016489978897 0.0888226936960841 no 342 0.120967307550989 142 17014829 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 1.16733642806298 0.0893581957608094 no 343 0.121537266506407 156 6728940 SGTC_1891 st059073 26.2 µM 1.16631574823961 0.089552025111515 no 344 0.121743404146252 167 688754 SGTC_179 1273-0063 6.77 µM 1.16529693291519 0.0897458120212552 no 345 0.121949410096916 122 3108139 SGTC_491 tetrandrine 80.3 µM 1.16468155002796 0.0898630137393819 no 346 0.122073959962315 134 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_2050 5263056 171 µM 1.16450614792452 0.0898964404778075 no 347 0.122109476666379 157 763468 YGL055W OLE1 SGTC_1584 6-fluoro-dl-tryptophan 90 µM 1.16340913978571 0.0901057092227795 no 348 0.122331771519008 145 94937 An inhibitor of serotonin biosynthesis. SGTC_288 1315-0019 35.1 µM 1.16123124543632 0.0905222433843299 no 349 0.122773935678777 181 6811474 SGTC_2983 9022671 12.99 µM 1.15896858561722 0.0909565016773932 no 350 0.123234495128203 139 6405161 SGTC_2551 apiole 73.87 µM 1.15429756090049 0.0918578674787186 no 351 0.124189098076258 128 10659 A possible DNA adduct former. SGTC_1841 st054148 70 µM 1.15425518714153 0.0918660744983839 no 352 0.124197781481589 166 675442 SGTC_1089 terbinafine 2.25 µM 1.15169760265624 0.0923624378903828 no 353 0.124722678876157 144 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_337 1315-0038 354 µM 1.15105773964066 0.0924869291611372 no 354 0.124854241151573 123 1626437 SGTC_2121 5257820 149.641 µM 1.14561904813232 0.0935500926963815 no 355 0.125976406119469 140 791256 SGTC_2032 5185112 25.99 µM 1.1445566641501 0.0937588186391952 no 356 0.126196426258656 135 5718189 SGTC_3128 9127691 49.47 µM 1.14432970415582 0.0938034538669908 no 357 0.126243464463094 139 41316314 SGTC_956 1185-0240 191 µM 1.14369201956772 0.0939289484475019 no 358 0.126375692083044 148 1416193 SGTC_737 1950-0117 57.9 µM 1.14153605270122 0.094354154431928 no 359 0.126823458932694 153 5393513 SGTC_509 pifithrin 175 µM 1.14026957854443 0.0946045930425999 no 360 0.127087003880572 167 4817 A p53 inhibitor. SGTC_3026 9090633 49.47 µM 1.13961620168125 0.0947339863285567 no 361 0.127223116232854 146 25236842 SGTC_732 3970-1727 52.7 µM 1.13917621866377 0.0948211930333395 no 362 0.12731483121397 166 1275699 SGTC_1642 st009582 77.7 µM 1.13708638181844 0.0952362163816589 no 363 0.127751088148746 170 6739311 SGTC_735 3076-0345 636 µM 1.13372393820677 0.0959067731673949 no 364 0.128455182534835 153 2888990 SGTC_2463 5473429 200 µM 1.13297821412518 0.0960559588437561 no 365 0.128611701128209 146 5399405 SGTC_2776 terbinafine 19.92 µM 1.12913898063566 0.0968267170931504 no 366 0.129419604834893 146 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_196 k015-0023 18.111 µM 1.12425676958298 0.0978134087400001 no 367 0.130452056142804 131 5211998 SGTC_1194 1488-0194 225 µM 1.11846466300643 0.098993524329434 no 368 0.131684295283778 154 1391452 SGTC_1423 4048-0112 5.59 µM 1.11811899053806 0.0990642814610496 no 369 0.131758088356869 163 X1423 SGTC_2985 9022375 71.43 µM 1.11672845436404 0.0993492897928343 no 370 0.132055223863944 156 4939335 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 1.1147318125073 0.0997595749526338 no 371 0.132482682112253 161 688751 SGTC_207 4185-0010 4.486 µM 1.11391711097347 0.099927341122288 no 372 0.132657374003448 166 3761753 SGTC_3166 9102297 49.47 µM 1.11263489237986 0.100191797217286 no 373 0.13293263421883 161 25237072 SGTC_780 0109-0199 192 µM 1.11066357425716 0.100599375260776 no 374 0.133356593405103 176 610414 SGTC_334 1502-1024 68.5 µM 1.10973914102438 0.100790921623571 no 375 0.133555725575322 140 3296216 SGTC_305 1682-2595 20.8 µM 1.10626878693493 0.101512366447189 no 376 0.134305098757318 166 226033 SGTC_1759 st043059 70 µM 1.10593948212076 0.101581019829264 no 377 0.134376357113945 169 669426 SGTC_1568 digitonin 820 nM 1.10380028861069 0.102027821702471 no 378 0.134839889821799 180 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_3047 9092122 49.47 µM 1.10180296943893 0.102446280360129 no 379 0.135273669578607 158 17173831 SGTC_2515 chrysin 20.77 µM 1.09719355360547 0.103416759991358 no 380 0.136278395279584 139 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_3197 9113331 49.47 µM 1.09479326610167 0.103924757800692 no 381 0.136803608618708 154 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_1279 0874-0590 65.2 µM 1.0910686268453 0.104716620911627 no 382 0.137621343219083 157 3523074 SGTC_2246 7293507 91.5585 µM 1.090319601104 0.104876391099212 no 383 0.137786191904749 175 887656 SGTC_3330 9141424 71.43 µM 1.08996378567984 0.104952349756648 no 384 0.137864548421241 144 27261020 SGTC_72 0744-0168 198.391 µM 1.08913241414679 0.105129984259827 no 385 0.138047748838094 169 677577 SGTC_725 1497-0963 19 µM 1.08572061431163 0.105861243048771 no 386 0.138801308794402 159 3549977 SGTC_2685 mycophenolic acid 18.85 µM 1.08183616422757 0.106698273357135 no 387 0.139662667025857 152 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_13 0199-0087 65 µM 1.08163094725453 0.10674262644713 no 388 0.139708273767506 178 4589825 SGTC_1314 1222-0010 41.1 µM 1.08058223449864 0.106969490144516 no 389 0.139941494297922 158 3526027 SGTC_565 1418-0001 44.5 µM 1.07798016578205 0.107533886553978 no 390 0.140521303812629 168 2862145 SGTC_277 nystatin 15.5 µM 1.07654570069658 0.107845942361969 no 391 0.140841636807228 155 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1807 st050092 58.9 µM 1.07329549187684 0.108555409852846 no 392 0.141569278623528 168 5008496 SGTC_1780 st038448 24.544 µM 1.07091324393727 0.109077543648336 no 393 0.142104220151601 160 728868 YDL195W SEC31 SGTC_1411 3909-8223 150 µM 1.06925471599426 0.109442118846598 no 394 0.142477454808178 178 X1411 SGTC_1885 st057546 99.9 µM 1.0672464811138 0.10988473651668 no 395 0.14293027416094 163 702008 SGTC_393 acivicin 6.25 µM 1.06723817695072 0.109886569428572 no 396 0.142932148611042 164 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_451 chloral hydrate 100 µM 1.06354020080955 0.110704976021191 no 397 0.143768522243453 189 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_2651 TUB2.036 5 µM 1.06272392524868 0.110886214613114 no 398 0.143953583812206 180 15992207 YFL037W TUB2 SGTC_2201 6605497 169.863 µM 1.05871034462888 0.111780446653643 no 399 0.144865857622068 172 670741 SGTC_2973 9094665 17.96 µM 1.05712592773936 0.112134873446523 no 400 0.145227059786335 193 25237061 YIL048W NEO1 SGTC_1736 st036774 51 µM 1.05275910748692 0.113115867078173 no 401 0.146225705516192 188 1272247 SGTC_601 0986-0029 62.9 µM 1.0515872668351 0.113380156781628 no 402 0.146494476125771 171 24747981 SGTC_3321 9137793 26.8275 µM 1.04996063028558 0.113747747884153 no 403 0.14686810695719 184 4904192 SGTC_2851 9015922 71.43 µM 1.04867134655801 0.114039706085712 no 404 0.147164703135674 186 2996893 SGTC_370 0180-0345 38.7 µM 1.04722461352933 0.114367953837042 no 405 0.14749799787469 154 3989527 SGTC_140 0062-0056 502.533 µM 1.04492291646665 0.11489156896406 no 406 0.14802929865911 146 3758964 SGTC_349 k015-0014 24 µM 1.04486672454656 0.114904373402496 no 407 0.148042285438237 171 2196908 SGTC_402 epigallocatechin gallate 10 µM 1.04420449346209 0.115055352305301 no 408 0.148195394228232 203 65064 An antioxidant. SGTC_2910 7948405 25.97 µM 1.03594514947372 0.116950220383738 no 409 0.150113866247927 154 2971328 SGTC_2249 haloperidol 116.36 µM 1.03567966608562 0.117011492612349 no 410 0.150175805869521 204 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1812 st052057 4.327 µM 1.03500014476509 0.117168426328527 no 411 0.150334421795186 166 3645418 SGTC_2348 9022543 33.42 µM 1.03406862772071 0.117383800033441 no 412 0.150552040671466 207 3162678 YDL140C RPO21 SGTC_1523 st012844 44.7 µM 1.02973923000351 0.118388468318734 no 413 0.15156621731557 141 4274103 SGTC_2027 5150920 200 µM 1.02684515698233 0.119063439614287 no 414 0.152246691039199 166 786715 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 1.02528685168495 0.11942799922846 no 415 0.152613928955537 170 17037758 SGTC_1764 st044502 93.5 µM 1.02262246029082 0.12005314664626 no 416 0.153243192936967 166 8407 SGTC_1039 k821-0043 94 µM 1.02169232634678 0.120271926552231 no 417 0.153463272075369 161 15992768 SGTC_2052 5265182 7.135 µM 1.02114793088129 0.120400105856652 no 418 0.153592178644175 174 1239884 SGTC_2286 7945697 125 µM 1.02035401611364 0.120587207545445 no 419 0.153780296997348 175 1245733 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 1.01919420196979 0.120860908488592 no 420 0.15405538935925 183 279621 SGTC_2556 citropten 84.59 µM 1.01794973545184 0.121155072186877 no 421 0.154350921990775 156 2775 A potential DNA crosslinker. SGTC_1611 st001856 99.4 µM 1.01790485497175 0.12116569031613 no 422 0.154361587087656 195 647478 SGTC_1136 pergolide 1.05886 µM 1.01697731888473 0.1213852796725 no 423 0.154582109644207 195 47811 A dopamine receptor agonist. SGTC_2605 digitonin 300 nM 1.01667116958658 0.121457820311995 no 424 0.154654942602787 198 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2634 4'-methoxyflavone 100 µM 1.01265038029583 0.122413356701164 no 425 0.155613593274944 159 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_3044 9093193 49.47 µM 1.01242304468292 0.122467539910401 no 426 0.15566791224739 179 25236277 SGTC_1368 1852-0141 284 µM 1.01228443593695 0.122500584200341 no 427 0.155701037191797 179 2838987 SGTC_2308 7584454 197.62 µM 1.01093006161778 0.122823795944067 no 428 0.156024952382776 181 893577 SGTC_493 zm226600 134 µM 1.01043588718621 0.122941875917146 no 429 0.156143250751887 187 5240098 A potassium channel opener. YCR052W RSC6 SGTC_1482 3346-2049 8.48 µM 1.01007114777008 0.123029079217091 no 430 0.156230602107199 163 3826804 SGTC_2789 5281112 71.43 µM 1.00910094851805 0.123261249216926 no 431 0.156463111573183 172 765948 SGTC_237 nikkomycin 200 µM 1.00871897447968 0.123352740300043 no 432 0.156554714612882 176 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_2396 5342950 42.78 µM 1.00667250299682 0.123843724962402 no 433 0.157046090053184 228 1886677 SGTC_488 nitrendipine 139 µM 1.00439405314459 0.124391972817672 no 434 0.157594357650422 166 4507 Dihydropyridine L-type calcium channel blocker. SGTC_2309 7664088 163.95 µM 1.00405870524472 0.124472808359211 no 435 0.157675159079867 183 704922 SGTC_2362 9071156 126 µM 1.00354852763816 0.124595856995375 no 436 0.157798137578217 172 653133 SGTC_2619 obliquin 87.91 µM 1.00343120921747 0.12462416479297 no 437 0.157826426132804 180 6708593 A bioactive alkalod. YER133W GLC7 SGTC_899 1083-0020 478 µM 1.00228950678817 0.124899881283632 no 438 0.158101894500652 206 767123 SGTC_2164 5685496 200 µM 0.999681774522777 0.125531235573018 no 439 0.158732267432621 151 759046 SGTC_637 1181-0519 7.26 µM 0.993867974570189 0.126946814377126 no 440 0.160143573798569 191 6252091 YGR060W ERG25 SGTC_12 0849-0099 9.267 µM 0.993481233626377 0.127041372962653 no 441 0.160237745707493 186 6071388 SGTC_655 k060-0012 42 µM 0.987851851826865 0.128423314287383 no 442 0.161612604424044 199 5994525 SGTC_1054 3429-0080 167 µM 0.983651475808466 0.129461227678999 no 443 0.162643453000929 182 1162877 SGTC_1738 st035555 74 µM 0.979312487125407 0.130539480257331 no 444 0.163712801193099 192 5331140 SGTC_2469 5655019 90.81 µM 0.976233247371436 0.131308438490948 no 445 0.164474445434479 176 2788239 SGTC_834 0312-0008 75.7 µM 0.975721354419362 0.131436572732759 no 446 0.164601283493319 179 6385573 YIL048W NEO1 SGTC_2647 atorvastatin 60.16 µM 0.974578373828118 0.131722988860052 no 447 0.164884722659419 173 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_1507 4075-3230 155 µM 0.974125167515652 0.131836675638883 no 448 0.164997197351558 182 659771 SGTC_372 0155-0182 15.9 µM 0.973498486657307 0.131993989983904 no 449 0.165152805992283 185 771486 SGTC_1250 0485-0349 40.2 µM 0.973450548510909 0.132006029121621 no 450 0.165164713233395 179 6842794 YDL195W SEC31 SGTC_449 xestospongin c 11.1929 µM 0.972343831566793 0.132284179466746 no 451 0.165439762489988 186 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.972256338564205 0.132306186236797 no 452 0.16546151951205 221 5393153 SGTC_3095 9117207 49.47 µM 0.972251653959789 0.132307364608049 no 453 0.165462684492174 146 17015229 SGTC_3160 9100216 49.47 µM 0.972092500118829 0.132347402661915 no 454 0.165502266453036 186 17191039 SGTC_1779 st039427 55 µM 0.968078380046993 0.133359989857696 no 455 0.166502613223034 192 1124498 SGTC_121 0557-0495 61.343 µM 0.966951334676344 0.133645249960184 no 456 0.166784181153618 220 3104427 SGTC_397 arbidol 50 µM 0.965955984612629 0.133897526043293 no 457 0.167033103161007 184 131410 A RNA synthesis inhibitor. SGTC_1835 st008666 49.2 µM 0.964001761615216 0.134393784498838 no 458 0.167522521338492 157 690455 SGTC_3054 9094397 49.47 µM 0.960176042394924 0.135368946096334 no 459 0.168483311137751 196 2598354 SGTC_2639 lactacystin 53 µM 0.958404874001593 0.135822048686959 no 460 0.168929319223703 188 3870 A proteasome inhibitor. SGTC_1952 st077036 64.1 µM 0.957847853285956 0.13596476088133 no 461 0.169069742439425 179 2937007 SGTC_616 4092-0450 108 µM 0.956349483877358 0.136349161881941 no 462 0.169447848697871 210 787165 SGTC_1400 3771-8998 51.5 µM 0.956103201543056 0.136412415761821 no 463 0.16951004873742 159 670767 SGTC_2284 7945075 39.21 µM 0.95503673921668 0.136686552065822 no 464 0.169779559059718 210 1245402 SGTC_1547 harmine 94.2 µM 0.954828809466939 0.136740044678343 no 465 0.169832137883338 195 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_3157 9099274 49.47 µM 0.954757292597493 0.13675844662369 no 466 0.169850224639013 188 17217662 SGTC_2376 9072922 81.32 µM 0.953238446315927 0.137149659479894 no 467 0.170234635446166 184 17087968 SGTC_2204 7233102 200 µM 0.950962286798566 0.137737365410533 no 468 0.170811760383425 176 2172480 SGTC_975 1335-0046 28.5 µM 0.949107669853188 0.138217497600768 no 469 0.171282926950965 200 16486740 SGTC_2669 eugenol 100 µM 0.948929864407114 0.138263588602722 no 470 0.171328142141738 166 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_346 4513-0042 7.16 µM 0.947909481934183 0.138528296313236 no 471 0.171587768712855 196 2827372 SGTC_2178 5812956 200 µM 0.94760163797307 0.138608224981712 no 472 0.171666146001561 211 5403383 SGTC_1088 bifonazole 369 nM 0.944114959140064 0.139515700201036 no 473 0.172555452898007 195 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_264 promethazine 12.5 mM 0.943727336221364 0.139616835538554 no 474 0.172654500534156 236 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_1021 4476-0760 85.3 µM 0.939332837062193 0.140766898017458 no 475 0.17377994213319 173 746768 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.936588118835439 0.14148845686832 no 476 0.17448523293246 203 4213774 SGTC_1666 st014829 29 µM 0.930648822759026 0.143058405003564 no 477 0.176017625332514 187 3858230 SGTC_1728 st035614 33.7865 µM 0.930555970833967 0.143083041846976 no 478 0.176041649422513 204 15945546 SGTC_477 mead ethanolamide 10 µM 0.929042297467449 0.143485076267646 no 479 0.176433583206682 144 16061185 SGTC_669 0108-0021 26.2 µM 0.928155485126676 0.143720969186429 no 480 0.176663460786496 239 17201 SGTC_3155 9099265 49.47 µM 0.926570982003957 0.144143099688095 no 481 0.177074663502253 195 25236499 SGTC_2710 st078562 53.7235 µM 0.92631644335262 0.144210989669902 no 482 0.177140776488166 207 17250908 SGTC_3232 9132874 49.47 µM 0.92404766839938 0.144817064584116 no 483 0.177730748922459 191 3784940 SGTC_3308 9128332 17.569 µM 0.922544376561692 0.145219593690495 no 484 0.178122347086136 194 17332805 YDL196W YDL196W SGTC_697 0508-1955 564 µM 0.921631098977172 0.145464504838751 no 485 0.178360515592604 191 6243113 SGTC_1636 st007707 68.9 µM 0.920754032868473 0.145699966602552 no 486 0.17858942949487 214 403051 SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.919522177049906 0.14603110951134 no 487 0.178911255646463 200 23665772 A membrane-active detergent. SGTC_2759 disulfiram 3.38 µM 0.919458417550239 0.146048262855382 no 488 0.17892792294204 208 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_375 3970-0961 9.27 µM 0.919041656827606 0.146160418155827 no 489 0.179036891937965 209 2898222 SGTC_1379 2144-0755 36.5 µM 0.9186808305933 0.146257567528708 no 490 0.179131269652496 220 5392327 SGTC_486 niguldipine 82 µM 0.918615252577774 0.14627522850337 no 491 0.179148425599287 208 1236 A calcium channel blocker. SGTC_848 0368-0089 85.6 µM 0.918416133578385 0.146328862500412 no 492 0.179200523703478 205 762535 SGTC_59 0330-0160 1.33 µM 0.915897558279106 0.147008396907158 no 493 0.179860313799432 188 4293482 SGTC_2545 solidagenone 89.61 µM 0.915199094352533 0.147197223010417 no 494 0.180043560003825 160 6708572 An anti ulcer agent SGTC_1073 triclabendazole 3.09 µM 0.914166211669853 0.147476755360962 no 495 0.18031475773084 204 50248 An antihelmetic and likely tubulin inhibitor. SGTC_2625 euphol 100 µM 0.91313320130854 0.147756677771971 no 496 0.180586245222139 218 6708538 A triterpene alcohol. SGTC_873 0591-4978 488 µM 0.912699800664147 0.147874225411669 no 497 0.180700224398993 226 3305145 SGTC_2391 6285546 200 µM 0.912526905167276 0.147921135879287 no 498 0.180745706426509 197 846083 SGTC_527 4476-4215 268 µM 0.911067008742949 0.14831763604913 no 499 0.181130034050539 178 4418754 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.910256225866321 0.148538147182248 no 500 0.181343699071658 209 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2518 prenyletin 46.28 µM 0.907481687006318 0.149294405014676 no 501 0.182076064681896 173 3873459 A coumarin with calcium channel inhibitory activity. SGTC_1721 st082152 9.2685 µM 0.905741070357242 0.149770156054165 no 502 0.182536459339878 197 5296051 SGTC_1634 st006576 41 µM 0.905549860027158 0.149822479869115 no 503 0.182587078929041 205 3915356 SGTC_2566 crystal violet carbinol 226 nM 0.905039463374712 0.149962207236535 no 504 0.182722240437984 243 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_992 3909-8734 162 µM 0.903439827813826 0.15040068994856 no 505 0.183146255037245 190 4288319 SGTC_1508 1080-0625 72.9 µM 0.90329562604127 0.150440259623087 no 506 0.183184508663458 201 767111 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.90233406806223 0.150704293161401 no 507 0.183439716689113 198 2724278 An inhibitor of dopamine biosynthesis. SGTC_2080 5212524 12.4 µM 0.900856251639691 0.151110686945291 no 508 0.183832377208715 222 260183 SGTC_2886 9058944 51.95 µM 0.899398002966177 0.151512413772335 no 509 0.184220351269335 160 4949929 SGTC_564 3555-0129 330 µM 0.898615051807262 0.151728398406454 no 510 0.184428869278195 214 563260 SGTC_1169 aniline yellow 25.8 µM 0.896659584390248 0.152268726254454 no 511 0.184950296437979 224 6051 A DNA damaging agent. SGTC_2010 4012422 159 µM 0.895139566799182 0.152689613486547 no 512 0.185356242626351 205 952393 SGTC_2223 6903751 107.57 µM 0.894938379154993 0.152745379374771 no 513 0.18541001458468 211 5598863 SGTC_342 k048-0088 23.3 µM 0.894747556616032 0.152798284708408 no 514 0.185461025180824 230 6820570 SGTC_2564 betulinic acid 100 µM 0.894096439411829 0.152978897688472 no 515 0.185635147105643 199 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_1703 st026983 48.3 µM 0.888891608599849 0.154427748470419 no 516 0.187030667843419 197 1104023 SGTC_55 0767-0285 6.563 µM 0.888665957735166 0.15449076662639 no 517 0.187091315837543 223 3116166 SGTC_452 diindolylmethane 8 µM 0.887622090454184 0.154782511580697 no 518 0.187372033439371 203 3071 Inhibits expression of several cancer promoting factors. SGTC_682 0kpi-0099 17 µM 0.887482393464984 0.154821582351045 no 519 0.187409620606397 243 1714895 YML126C ERG13 SGTC_2532 xanthone 78.9 µM 0.886344578758929 0.155140051563699 no 520 0.187715936979411 188 7020 An insecticide. SGTC_1066 ketoconazole 628 nM 0.885340996745905 0.155421308364725 no 521 0.187986372480708 222 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_1977 st070720 65.3 µM 0.884977079723771 0.155523380246274 no 522 0.188084496686732 180 682188 SGTC_1422 4031-0024 15.5 µM 0.884567672427663 0.155638264143239 no 523 0.188194924372698 235 782427 SGTC_80 0159-0065 512.242 µM 0.881992341628712 0.156362211580767 no 524 0.188890474366852 201 1548079 SGTC_938 3126-1755 342 µM 0.881488613572004 0.156504072747621 no 525 0.189026707125289 198 1777771 SGTC_1501 4491-0275 38.4 µM 0.877893938906225 0.157518873564528 no 526 0.190000639376599 217 5104718 SGTC_299 1273-0059 1.44 µM 0.877343927362864 0.1576745260948 no 527 0.190149929751447 210 2848077 SGTC_259 usnic acid 108.925 µM 0.875846035293411 0.15809893967034 no 528 0.190556869923091 244 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1138 3761-0006 1.03 µM 0.874173404416896 0.15857374919954 no 529 0.191011913630931 197 12061087 SGTC_694 1315-0438 43.2 µM 0.873471823461734 0.15877318499493 no 530 0.191202978839796 206 6793154 SGTC_860 0443-0016 25.1 µM 0.871107769389103 0.15944641576449 no 531 0.191847656163486 237 5337942 SGTC_700 3453-2283 142 µM 0.870261983223669 0.159687730366219 no 532 0.192078624805118 220 565664 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.868938445352565 0.160065833540898 no 533 0.192440399930527 225 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_2588 indole-3-carbinol 100 µM 0.867434973327022 0.160496049185826 no 534 0.192851863201009 218 3712 Induces cell cycle arrest. SGTC_3233 9132340 49.47 µM 0.86492075657921 0.16121717383342 no 535 0.193541142085321 249 17682950 SGTC_2954 9074818 52.69 µM 0.864652613066977 0.161294206982377 no 536 0.193614742877686 222 16648742 SGTC_893 0958-0369 48.9 µM 0.863572608709055 0.161604717234873 no 537 0.19391135832438 224 6819948 SGTC_2358 9037157 4 µM 0.863428434594718 0.161646197956278 no 538 0.193950975651957 235 2388925 SGTC_308 4092-1169 104 µM 0.862969869099534 0.161778179203462 no 539 0.194077016772197 222 2268590 YDL196W YDL196W SGTC_2458 5808907 16.39 µM 0.861853565974261 0.162099759543565 no 540 0.194384051908614 237 2731747 SGTC_1296 1068-0102 11.9 µM 0.861236707842386 0.16227764013414 no 541 0.194553843290243 207 767053 SGTC_2320 7373003 200 µM 0.860498546515168 0.162490667330981 no 542 0.194757142193605 220 5415828 SGTC_932 2857-0803 154 µM 0.859894948493655 0.16266499585964 no 543 0.194923476671753 213 674898 SGTC_1621 st003705 32.4 µM 0.859098689713606 0.162895153864229 no 544 0.195143035081873 219 24207032 SGTC_580 1123-0028 41 µM 0.858948703989268 0.162938530813047 no 545 0.195184408588075 235 1677248 YPR107C YTH1 SGTC_2420 aureobasidin a 50 nM 0.858724190371602 0.163003475796969 no 546 0.195246350547472 198 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_1235 benzylparaben 21.5 µM 0.85583172019857 0.16384168440521 no 547 0.196045433511549 229 7180 SGTC_1019 4262-0212 3.4 µM 0.855629501849744 0.163900389674364 no 548 0.196101373085715 231 4677213 SGTC_805 3852-0218 479 µM 0.854810703852177 0.164138231433017 no 549 0.196327975761141 219 6615355 SGTC_1550 gossypolone 36.6 µM 0.854218625633499 0.164310355766874 no 550 0.196491932492367 223 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2488 5268135 45.7 µM 0.852905702981422 0.16469245567556 no 551 0.196855799423283 230 1270356 YLR208W SEC13 SGTC_977 1348-1378 135 µM 0.852692163677785 0.164754656411404 no 552 0.196915018833512 227 X977 SGTC_255 tunicamycin 200.472 nM 0.852561758702388 0.164792648871376 no 553 0.196951188466634 217 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_315 k915-0449 187 µM 0.852487905875995 0.16481416782613 no 554 0.196971674358596 221 20970215 YNL149C PGA2 SGTC_1895 st058434 18.3 µM 0.851164799036786 0.165199998026474 no 555 0.197338906907463 248 5393175 SGTC_3214 9129694 49.47 µM 0.850692487838218 0.165337869819147 no 556 0.197470098628603 236 17158655 SGTC_3039 9090270 49.47 µM 0.849243697334142 0.165761248824973 no 557 0.197872851404956 198 17173750 SGTC_153 4077-0274 519.67 µM 0.848327042958675 0.166029483773158 no 558 0.198127930493454 236 3121976 SGTC_41 0478-0632 82.643 µM 0.845959901635157 0.1667234623491 no 559 0.198787556938896 235 3750424 SGTC_2225 6654152 15.4 µM 0.844821718220718 0.167057810772166 no 560 0.199105193365126 229 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_3096 9117468 49.47 µM 0.844650385236874 0.167108178311491 no 561 0.199153034264298 216 41316311 SGTC_2881 9058953 51.95 µM 0.844205336066186 0.167239057191125 no 562 0.199277336629995 196 17122249 SGTC_1938 st074717 56.4 µM 0.842721564789669 0.167675877916685 no 563 0.199692091814677 219 17250979 SGTC_1631 benzylvanillin 81.9 µM 0.840844169978279 0.168229633069898 no 564 0.200217619347369 206 75506 SGTC_1480 1070-0044 41.2 µM 0.839780794899324 0.16854380679192 no 565 0.200515651711305 225 3124987 SGTC_1531 st059297 52.4 µM 0.839113979438859 0.168741009445743 no 566 0.200702676064634 229 7566702 SGTC_2809 7964133 12.99 µM 0.838169235895381 0.169020659742512 no 567 0.200967831205206 238 1253665 SGTC_2899 9053889 58.44 µM 0.837606854256921 0.169187269657596 no 568 0.201125771008125 211 6470052 SGTC_979 1426-2828 121 µM 0.83731403204044 0.169274062238694 no 569 0.201208036944318 216 747872 SGTC_1789 tunicamycin 25 nM 0.836814355964077 0.169422232345319 no 570 0.201348463311225 231 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_157 1348-1695 65.819 µM 0.834527672806248 0.170101369436599 no 571 0.201991850062489 238 5380510 SGTC_1822 st052468 42 µM 0.834424502425502 0.170132051765556 no 572 0.202020907314755 231 2873678 SGTC_147 4466-0538 29.23 µM 0.833416848166942 0.170431909306104 no 573 0.202304837959558 247 6742687 YHR072W ERG7 SGTC_969 1313-0238 134 µM 0.833273139617352 0.170474701627377 no 574 0.202345350712603 248 5212874 SGTC_1129 3453-1384 223 µM 0.832286633142789 0.17076864092459 no 575 0.202623586851434 236 1084452 SGTC_2919 7978188 46.38 µM 0.832240827606599 0.170782297009753 no 576 0.202636511483714 209 2980291 SGTC_1006 4099-6547 255 µM 0.83215985861814 0.170806438146424 no 577 0.202659359150086 239 3146833 SGTC_1949 st076024 69.1 µM 0.832144357111881 0.170811060214136 no 578 0.202663733509541 251 2921930 SGTC_56 0957-0365 83.25 µM 0.83131645076283 0.17105803246198 no 579 0.20289744181235 205 6752360 SGTC_1436 4092-1007 8.32 µM 0.830223238739581 0.171384497623705 no 580 0.203206289314987 195 2881121 SGTC_1677 st019204 53.9 µM 0.827232507342136 0.172279651240262 no 581 0.204052644961561 209 3945625 SGTC_892 0929-0076 29 µM 0.825925498719355 0.172671786034423 no 582 0.204423177524893 231 5751038 SGTC_964 1287-0107 19.4 µM 0.825853313145108 0.172693460054138 no 583 0.204443653556958 208 51516812 YPR165W RHO1 SGTC_539 4859-0462 2.54 µM 0.825752761585757 0.172723653969573 no 584 0.204472177868572 223 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_394 menadione 8.33 µM 0.825082519405099 0.172925002213598 no 585 0.204662371645489 235 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_1118 chelidonine 707.474 nM 0.823781965879405 0.173316129507256 no 586 0.205031728190693 227 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_2829 7992743 58.44 µM 0.822651394838278 0.173656593684336 no 587 0.20535313149313 218 16462845 SGTC_2746 daunorubicin 9.88 µM 0.822483266659799 0.173707260721706 no 588 0.205400953198096 202 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1867 st057372 64 µM 0.82209596451449 0.17382401371465 no 589 0.205511141031338 204 688837 SGTC_3137 9097352 49.47 µM 0.821739992931993 0.173931366054234 no 590 0.205612446235777 254 44120435 SGTC_1356 1502-0781 85.8 µM 0.821469490431094 0.174012971189313 no 591 0.205689447792107 227 567702 SGTC_2831 7999036 19.48 µM 0.819280410155685 0.174674267793704 no 592 0.206313223362601 230 2988270 SGTC_1705 st027868 56.3335 µM 0.818592147619343 0.174882513452474 no 593 0.206509574290062 223 292948 SGTC_1834 st055981 52.8 µM 0.817747825761398 0.175138192644402 no 594 0.206750597723656 225 471719 YDL150W RPC53 SGTC_1086 cerivastatin 2.18 µM 0.816333046977266 0.175567149931017 no 595 0.207154839179855 217 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_2243 6634756 200 µM 0.815723566277116 0.175752147935229 no 596 0.207329128668812 196 885676 SGTC_1685 st024049 53.0905 µM 0.815397747478267 0.175851095594295 no 597 0.207422336642057 237 1941139 SGTC_2336 9001819 198.65 µM 0.811148795862683 0.177144685268683 no 598 0.208640113292817 250 2989602 SGTC_3119 9125183 49.47 µM 0.808786045453922 0.177866616491158 no 599 0.209319112135017 194 22695334 SGTC_1445 4239-0156 97.7 µM 0.808593199828078 0.177925621685616 no 600 0.209374588774178 243 4008346 SGTC_1098 clofazimine 15.1 µM 0.807667194152463 0.178209124613614 no 601 0.209641096867093 240 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_3071 9117417 49.47 µM 0.80763842267511 0.178217937754922 no 602 0.209649380606321 233 45595590 YGL055W OLE1 SGTC_2030 5175110 200 µM 0.804439943684021 0.179199392829411 no 603 0.210571470203271 239 2831986 SGTC_328 k915-0120 63.5 µM 0.802370948647565 0.179836072342972 no 604 0.211169206407654 211 6624543 SGTC_2935 9038016 29.96 µM 0.802074257518718 0.179927487681703 no 605 0.211255002420963 231 6463195 SGTC_1745 st081495 74 µM 0.80143358253408 0.180124989541881 no 606 0.211440340029068 233 13842402 YBL026W LSM2 SGTC_245 methotrexate 289.6 µM 0.800804043167986 0.180319191118677 no 607 0.211622548991147 219 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_453 enantio-paf c16 10 µM 0.800716944918642 0.180346069705127 no 608 0.211647765264814 267 13871343 A lipid and platelet activating factor SGTC_2065 5221596 34.26 µM 0.799521064560568 0.18071537348965 no 609 0.211994168712289 232 788581 SGTC_1906 st060206 94.7 µM 0.799379641467274 0.180759078154534 no 610 0.212035155800362 248 5133468 SGTC_2439 5492030 7.2 µM 0.79850086408583 0.181030799485652 no 611 0.212289945957599 235 5722370 SGTC_2211 7117706 200 µM 0.797709886910034 0.181275591381914 no 612 0.212519432519645 229 822771 SGTC_683 panaxydol 45 µM 0.794607665911925 0.182237667273367 no 613 0.213420878849229 210 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_1096 rimcazole 32.2 µM 0.7944055168968 0.182300469260194 no 614 0.213479696749111 235 18528119 A dopamine reuptake inhibitor. SGTC_2337 9009472 200 µM 0.794342134848264 0.182320163056294 no 615 0.213498140530367 229 5742383 SGTC_2163 5671233 125 µM 0.794036472818113 0.182415155703983 no 616 0.213587099313814 242 701023 SGTC_1650 st011916 45.8 µM 0.793903213483053 0.182456579281843 no 617 0.213625889393197 258 242528 SGTC_2466 5983409 37.09 µM 0.793489437160739 0.182585238828858 no 618 0.213746360515985 224 2879657 SGTC_405 ebelactone b 50 µM 0.793173110838202 0.182683635491804 no 619 0.213838485719268 233 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_3317 9138495 8.753 µM 0.793113946903451 0.182702042736887 no 620 0.21385571887667 251 17020139 SGTC_3310 9130229 44.1445 µM 0.790023464917223 0.183665171596079 no 621 0.214757032382629 230 7761258 SGTC_790 1575-0012 79.1 µM 0.789540771039198 0.183815885174282 no 622 0.214898005078598 252 378741 YLR208W SEC13 SGTC_960 1222-0186 7.7 µM 0.788091249126811 0.184268938444378 no 623 0.215321666732374 234 3126296 SGTC_2055 5235184 200 µM 0.787855218877132 0.184342776276683 no 624 0.215390698757596 253 2836034 SGTC_2960 9079389 5.97 µM 0.787533977359363 0.184443300499311 no 625 0.215484673242407 216 16457355 SGTC_369 0957-0393 4.5 µM 0.786533074466911 0.184756725744438 no 626 0.215777625112469 252 6997992 SGTC_1403 3909-7815 62.9 µM 0.786207579852205 0.184858723245893 no 627 0.215872943071117 235 6615483 SGTC_2074 5212007 75.395 µM 0.785005844461112 0.185235603963479 no 628 0.216225070963769 238 758611 SGTC_3335 9143315 29.6265 µM 0.781583464525745 0.186311521169087 no 629 0.2172297038796 235 4899691 SGTC_878 0828-0289 13.7 µM 0.781565026919605 0.186317327992677 no 630 0.217235123494205 240 745350 YLR208W SEC13 SGTC_903 1134-0042 114 µM 0.780984535201463 0.186500208033031 no 631 0.217405795198593 251 701009 SGTC_2481 5478948 45.16 µM 0.779399761866423 0.187000046079742 no 632 0.217872132036591 232 77792 SGTC_2235 salicylic acid 500 µM 0.779053938286757 0.187109229011945 no 633 0.217973971021079 241 338 A COX inhibitor and kinase inhibitor. SGTC_1015 4130-4525 82 µM 0.778860062792308 0.187170456354337 no 634 0.218031075961414 244 1363237 SGTC_1898 st060199 18.6 µM 0.777751291413293 0.187520852721245 no 635 0.218357824015989 236 688866 SGTC_1994 st072947 40.9 µM 0.776617933553073 0.187879437613241 no 636 0.218692108890696 253 5286565 YDL195W SEC31 SGTC_230 MPP+ 141.667 µM 0.776223701927533 0.188004268374427 no 637 0.218808456860408 248 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_572 0960-0087 17.7 µM 0.775541675726556 0.188220348205926 no 638 0.219009824554481 277 6796365 SGTC_3086 9117350 49.47 µM 0.77295080608111 0.1890425845134 no 639 0.219775747524053 221 2679265 SGTC_2891 9063876 19.48 µM 0.772667538827186 0.189132615956492 no 640 0.219859581240357 220 6472478 SGTC_116 0155-0182 31.788 µM 0.771406742461559 0.189533657811661 no 641 0.220232939934211 216 771486 SGTC_876 0720-0963 56.8 µM 0.77118367527142 0.189604666831367 no 642 0.220299034487573 241 765861 SGTC_2479 5617353 43.85 µM 0.769992964102604 0.189983982918212 no 643 0.220652033158567 250 2731746 SGTC_913 3487-1245 167 µM 0.769042950577172 0.190286956028634 no 644 0.220933906754736 240 4016153 SGTC_911 3456-4043 236 µM 0.768473762425067 0.190468620497033 no 645 0.221102886322521 250 914281 SGTC_2764 methyldopa 94.69 µM 0.767316861793797 0.190838189802426 no 646 0.221446572744428 246 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_1341 1486-1360 280 µM 0.766548201297937 0.191083979767854 no 647 0.221675091453985 267 3976547 SGTC_2009 4012297 12.05 µM 0.765906620233786 0.191289282869546 no 648 0.221865933247736 228 45595307 SGTC_2915 7971052 15.16 µM 0.764817972383102 0.191637954571064 no 649 0.222189972100725 217 5741558 SGTC_702 1488-0190 94 µM 0.764728437668292 0.191666648027165 no 650 0.222216634354907 223 949357 SGTC_1215 3852-0577 11.2 µM 0.76286174479526 0.192265471770587 no 651 0.222772926480877 239 2884876 SGTC_1133 3473-0247 50 µM 0.762698347843279 0.192317942932307 no 652 0.222821658061629 242 711311 SGTC_916 4466-0038 42 nM 0.762600730513738 0.192349294664248 no 653 0.222850774396174 265 5722064 YGL116W CDC20 SGTC_1770 st043884 66.3 µM 0.760281262060191 0.193095156882478 no 654 0.223543239953939 278 670149 SGTC_1620 st003704 16.5 µM 0.759895799925473 0.193219279289754 no 655 0.223658436197652 247 2834414 SGTC_670 4204-0025 119 µM 0.759869588638596 0.1932277213369 no 656 0.223666270726401 231 719039 SGTC_679 0422-0091 41.4 µM 0.759133567970485 0.193464868420031 no 657 0.223886330307646 263 627384 YHR062C RPP1 SGTC_366 0181-0206 4.31 µM 0.757627703409413 0.193950613411589 no 658 0.224336945301966 240 274874 SGTC_2407 paclitaxel 400 µM 0.756674743379778 0.194258392255786 no 659 0.224622374904965 265 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_3075 9116269 49.47 µM 0.75558161295735 0.194611808167869 no 660 0.224950041738521 247 17015205 YNL244C SUI1 SGTC_2014 4013930 200 µM 0.755577519477459 0.194613132350432 no 661 0.224951269271766 250 64556 SGTC_2859 9028643 45.46 µM 0.755557874063482 0.194619487438922 no 662 0.224957160497736 219 17151580 SGTC_1778 st046819 58.9 µM 0.755114274547074 0.19476302091628 no 663 0.22509020947839 269 671715 SGTC_263 alizarin 107.927 µM 0.754982332318657 0.194805725284392 no 664 0.225129791565076 260 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_942 3253-1115 227 µM 0.752982050922685 0.195453832987809 no 665 0.225730350013581 274 46497897 SGTC_865 0488-0499 301 µM 0.752817390422284 0.195507242627954 no 666 0.225779827525044 237 9634651 SGTC_365 0121-0052 13.6 µM 0.752226617885126 0.195698939835477 no 667 0.225957394496643 218 3101739 SGTC_1475 4092-1048 11.7 µM 0.752180247015959 0.195713991344762 no 668 0.22597133540977 257 2881759 SGTC_2741 miltefosine 3.04 µM 0.751637384512438 0.195890251217125 no 669 0.226134577464783 230 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_1243 0416-0003 5.65 µM 0.751213824847824 0.196027841995859 no 670 0.226261990700987 256 2141977 SGTC_1255 0566-0045 221 µM 0.750542332613284 0.196246092262695 no 671 0.22646406894431 247 2788469 SGTC_2278 7948257 134.34 µM 0.749873347689055 0.196463674035394 no 672 0.226665493939951 252 1247028 SGTC_3297 9117502 71.43 µM 0.745931340117365 0.197748745399136 no 673 0.227854446066158 229 7453720 SGTC_1000 4048-0884 8.67 µM 0.745675263612451 0.197832400166344 no 674 0.227931802707186 262 13040088 SGTC_2638 epoxomicin 18 µM 0.744900091936373 0.19808576261615 no 675 0.228166059780605 248 9915668 A protesome inhibitor. SGTC_548 1436-0017 110 µM 0.744443729809662 0.198235014742445 no 676 0.228304035809635 249 9677137 SGTC_1616 st002734 56.1 µM 0.743250950514984 0.198625430760867 no 677 0.228664880776814 246 4026101 SGTC_2089 5281248 129.67 µM 0.743103689699773 0.198673663754677 no 678 0.228709452982311 243 2737878 SGTC_699 0375-0592 111 µM 0.742559974426692 0.198851810424268 no 679 0.228874064393179 221 762578 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.741627279967765 0.199157629121772 no 680 0.229156595212497 272 7104 SGTC_1248 0469-0687 58.6 µM 0.739173431175812 0.199963567158917 no 681 0.229900845969162 246 4017482 SGTC_786 4544-0069 423 µM 0.737588130383033 0.200485281887488 no 682 0.230382385233309 258 748821 YLR208W SEC13 SGTC_1828 st055811 49 µM 0.737212793124509 0.200608923125732 no 683 0.230496477413689 258 5877589 SGTC_428 3448-4153 16.5 µM 0.736575329887879 0.20081901713123 no 684 0.230690321011576 247 3834874 SGTC_376 3970-0862 59.1 µM 0.73639963273194 0.200876946293347 no 685 0.230743764049189 272 3135186 SGTC_996 3970-0799 1.8 µM 0.735129489615945 0.201296023740516 no 686 0.231130318041623 272 6615648 YGL040C HEM2 SGTC_3024 9090631 49.47 µM 0.734058666201562 0.201649743514273 no 687 0.23145649184967 246 25236383 SGTC_2803 7707263 71.43 µM 0.732151523965856 0.202280641609799 no 688 0.232038044229736 246 2199229 SGTC_3199 9111318 49.47 µM 0.731989445575075 0.202334312832692 no 689 0.232087504908271 236 8548020 SGTC_2642 cholecalciferol 100 µM 0.731653428448914 0.202445609884008 no 690 0.232190064322961 253 9821465 A vitamin D precursor, similar to steriods. SGTC_1171 0368-0077 21.4 µM 0.731045211976479 0.202647159055893 no 691 0.232375768767923 268 3239779 SGTC_2740 felodipine 17.08 µM 0.730046641545283 0.202978322646206 no 692 0.232680837608894 223 3333 L-type calcium channel blocker SGTC_2820 7989630 71.43 µM 0.72935649007781 0.203207391645926 no 693 0.232891812760474 210 2984098 SGTC_1421 4029-0249 71.4 µM 0.727611364814744 0.203787306229101 no 694 0.233425760841143 265 2894095 SGTC_306 1672-3436 11.6 µM 0.727296278399065 0.203892116193727 no 695 0.23352223873185 274 6797378 SGTC_2926 9010726 65.15 µM 0.726322698391254 0.204216169595422 no 696 0.233820483774422 267 2994293 SGTC_855 0428-0020 25 µM 0.726074640733678 0.204298783900175 no 697 0.233896507116149 245 6812414 SGTC_214 4373-3496 70 µM 0.725565999381997 0.204468246462604 no 698 0.234052435534901 270 3779166 SGTC_1726 st035556 14.5795 µM 0.725089339262585 0.204627129842031 no 699 0.23419861207169 234 5919439 SGTC_606 k015-0008 38.6 µM 0.724189152830038 0.204927385976123 no 700 0.234474808503341 268 1970475 SGTC_3318 9139014 38.6185 µM 0.724150477374812 0.204940291995168 no 701 0.234486678995536 283 16643984 SGTC_961 1252-1571 372 µM 0.723703792744118 0.205089385900691 no 702 0.234623802091876 274 6813498 SGTC_799 1310-0557 151 µM 0.723370841565529 0.205200559901053 no 703 0.234726040171591 270 5354492 SGTC_1597 7-benzyloxygramine 47.5 µM 0.722863001592772 0.205370199054914 no 704 0.234882028128384 263 260807 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.722784362624929 0.205396475106294 no 705 0.234906187969087 257 688664 SGTC_1596 piperlongumine 63 µM 0.721447309293614 0.205843537256031 no 706 0.235317174012372 242 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_1144 3486-0183 12.5 µM 0.720289748209292 0.206231049576007 no 707 0.23567330773273 282 6744069 SGTC_612 0302-0167 22.4 µM 0.719877686562291 0.206369098184025 no 708 0.235800153783205 288 235821 SGTC_2252 omeprazole 400 µM 0.719864395817227 0.206373551751647 no 709 0.235804245735713 246 4594 A proton pump inhibitor. SGTC_1875 nocodazole 6 µM 0.717304958894602 0.207232249123751 no 710 0.23659297405552 263 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_1699 st031318 29.054 µM 0.717277580934899 0.207241445904051 no 711 0.236601418817652 260 5340658 SGTC_1574 spiramycin 23.7 µM 0.716549917913556 0.207485970280484 no 712 0.236825928054916 277 6419898 An antibiotic and protein synthesis inhibitor. SGTC_3124 9127567 49.47 µM 0.716405477321739 0.207534528471627 no 713 0.236870506908625 236 17592030 SGTC_3173 9105693 49.47 µM 0.715559700965061 0.207818997235269 no 714 0.237131632344512 287 17096658 SGTC_2508 celastrol 40.54 µM 0.714541588619341 0.208161734828868 no 715 0.237446174555608 236 122724 Celastrol is a natural product and antioxidant. SGTC_2196 6573537 42.6665 µM 0.714366118720439 0.208220838740262 no 716 0.237500408490829 276 2903087 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.714167314506566 0.208287814363366 no 717 0.237561862770927 258 521171 SGTC_687 k029-0044 34.9 µM 0.712802737322522 0.20874787290873 no 718 0.237983915768138 252 5829338 SGTC_1201 1889-3372 45.9 µM 0.712669863269157 0.208792702525921 no 719 0.238025034618471 258 5392199 SGTC_1324 1418-0026 34.4 µM 0.712374015919822 0.208892537146756 no 720 0.238116600736927 256 1372513 SGTC_2192 5915882 198.485 µM 0.711598094223316 0.209154507933472 no 721 0.238356843756274 256 2876149 SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.710769317129651 0.209434537571073 no 722 0.238613598558932 270 1273210 SGTC_3188 9110789 49.47 µM 0.710111049752155 0.209657111991577 no 723 0.238817637329644 273 849217 SGTC_3211 9128781 49.47 µM 0.709767625378511 0.209773286386035 no 724 0.238924124174624 253 17194361 SGTC_3312 9133330 71.43 µM 0.709289674888128 0.209935031559937 no 725 0.239072367225128 278 17617324 SGTC_107 0358-0022 2.6945 µM 0.708187014063121 0.210308466985034 no 726 0.239414564668686 284 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_2138 5575593 77.673 µM 0.707896317805444 0.210406981300771 no 727 0.239504823270053 268 762213 SGTC_2946 9065502 71.43 µM 0.707824994528951 0.210431156248065 no 728 0.239526971350808 223 16489101 SGTC_809 3998-0021 90 µM 0.707454182965656 0.21055686869754 no 729 0.239642137814038 271 715485 SGTC_1388 3346-4487 254 µM 0.705846917499967 0.211102272744121 no 730 0.240141670712279 271 3345614 SGTC_2691 st077356 60.2 µM 0.705019655494787 0.211383315505675 no 731 0.240399002138552 283 2839272 SGTC_1575 cyproterone acetate 48 µM 0.700069928426838 0.213069440934709 no 732 0.241941817331169 276 9880 An androgen receptor antagonist and liver toxin. SGTC_3254 9136651 49.47 µM 0.698320080955524 0.213667398873137 no 733 0.242488521853633 290 16454030 SGTC_2199 6590217 200 µM 0.698054172760297 0.213758350518048 no 734 0.242571658030768 242 703109 SGTC_1506 4226-2149 212 µM 0.697740624138778 0.213865626132059 no 735 0.242669708811571 272 991114 SGTC_2834 9001755 58.44 µM 0.697396779036843 0.213983303229035 no 736 0.242777258363381 263 2989575 SGTC_761 k216-0224 480 µM 0.693575438056574 0.215293648884099 no 737 0.243974250780965 298 1340404 SGTC_3281 9140613 49.47 µM 0.691594519918075 0.215974738217464 no 738 0.244596002052445 247 16013766 SGTC_1731 st035964 63 µM 0.691372705537991 0.216051081202395 no 739 0.244665676077378 278 6739575 SGTC_132 0417-1715 25.805 µM 0.690004955051799 0.216522172088472 no 740 0.245095535651825 275 6769098 SGTC_3282 9108498 15.4605 µM 0.686999382046733 0.217559459473732 no 741 0.246041558918412 278 16459645 SGTC_2063 5246145 200 µM 0.686953154164628 0.217575436065573 no 742 0.246056124719577 272 711240 SGTC_164 4100-3994 89.624 µM 0.686218140126545 0.217829551622464 no 743 0.246287780167137 298 4615967 SGTC_161 4065-0411 162.148 µM 0.685912098720781 0.217935409421267 no 744 0.246384270149809 271 1906281 YLR208W SEC13 SGTC_1644 st010134 20.9 µM 0.685398653622629 0.21811307346719 no 745 0.246546196713231 282 3818134 SGTC_646 4092-0839 27.3 µM 0.685167544794145 0.218193069778429 no 746 0.246619100728829 283 877796 SGTC_2085 5307070 144.047 µM 0.684426799338523 0.218449586290572 no 747 0.246852849035235 296 2840351 SGTC_3136 9095672 49.47 µM 0.684300302582151 0.218493408851182 no 748 0.246892777976183 262 17217380 SGTC_2215 7188065 200 µM 0.68331968355695 0.218833298633361 no 749 0.247202429461079 274 940217 SGTC_2640 pentamidine 10.38 µM 0.683093160088367 0.218911856569621 no 750 0.247273988620484 271 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1455 4262-0120 131 µM 0.682932822281397 0.218967471240216 no 751 0.247324646306982 272 1529587 SGTC_329 k048-0121 21.3 µM 0.682242378774118 0.219207050865785 no 752 0.247542850806721 262 6832902 SGTC_1115 galangin 695.678 nM 0.681191190532809 0.219572095879634 no 753 0.247875260763456 296 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1027 k015-0025 8.67 µM 0.680630776618346 0.219766852819758 no 754 0.248052573885311 275 3598955 SGTC_1969 st069479 40.1 µM 0.679923293704019 0.220012861239492 no 755 0.24827651575619 281 3895485 SGTC_2953 9074162 66.49 µM 0.679574141859031 0.220134327736515 no 756 0.248387073639858 259 16451992 SGTC_503 tyrphostin 8 294 µM 0.678949177067302 0.220351842859841 no 757 0.248585032369326 298 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_325 2810-4341 181 µM 0.677891080604043 0.220720387515199 no 758 0.248920377851129 268 774970 SGTC_657 3534-0529 86.7 µM 0.676714795702499 0.221130512366222 no 759 0.249293463555212 282 1049549 SGTC_2994 9053520 71.4286 µM 0.676587163203769 0.221175039067467 no 760 0.249333962998302 271 4647384 SGTC_2989 9073649 71.4286 µM 0.676375509757484 0.221248889166088 no 761 0.249401131083782 291 21367202 SGTC_1156 4092-0367 4.88 µM 0.67625337064175 0.221291512351117 no 762 0.249439896229762 288 1357585 SGTC_2506 ethyl hematommate 54.16 µM 0.675882874304582 0.221420834087061 no 763 0.24955750586555 273 3940691 An allergen. SGTC_184 1494-0393 24.714 µM 0.675192317863836 0.221661988082806 no 764 0.249776793362992 287 3090647 SGTC_3261 9137475 49.47 µM 0.675182183391679 0.221665528329074 no 765 0.249780012345288 226 17027690 SGTC_2745 rifampicin 24.3 µM 0.675048224099041 0.221712326982873 no 766 0.249822563507332 249 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_1456 k015-0012 13 µM 0.674774639489447 0.22180792125011 no 767 0.249909477555429 285 2989616 SGTC_3114 9122766 49.47 µM 0.674595608222909 0.221870490006646 no 768 0.249966362 248 17176985 SGTC_283 0987-0079 11.7 µM 0.674537339745991 0.221890856144037 no 769 0.249984877398649 267 411556 SGTC_2441 5730946 39.09 µM 0.673332447778721 0.222312232095771 no 770 0.250367907086999 267 1774275 SGTC_3248 9135562 49.47 µM 0.673275273503792 0.222332238475841 no 771 0.250386090257719 280 17650701 SGTC_1830 st055982 50.3 µM 0.67319018090397 0.222362015917318 no 772 0.250413153606996 309 455313 An antimicrobial agent. SGTC_190 3970-0790 3.722 µM 0.672510058487945 0.222600100795636 no 773 0.250629519434296 275 2832352 SGTC_2568 diosmetin 100 µM 0.67121473354266 0.223053946314713 no 774 0.251041872011999 295 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_2298 7976326 193.81 µM 0.667869630770523 0.224228410723432 no 775 0.252108407208155 259 2235818 SGTC_3322 9139058 2.11 µM 0.667239777257623 0.22444994423802 no 776 0.252309493492108 263 4908926 YPR165W RHO1 SGTC_1213 1315-0166 115 µM 0.666239391321835 0.224802057440396 no 777 0.252629049241256 270 768401 SGTC_408 cantharidin 100 µM 0.66433526613833 0.225473131075493 no 778 0.253237877199203 267 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_300 r073-0011 5.04 µM 0.664037326419378 0.225578236910582 no 779 0.253333210666494 282 2735780 SGTC_412 gemfibrozil 100 µM 0.663296162909709 0.225839821486163 no 780 0.253570446788792 269 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_1119 parthenolide 318.541 nM 0.663181982542627 0.225880135291433 no 781 0.253607004706817 304 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_2531 methyl deoxycholate 70.07 µM 0.662598995477561 0.226086034685689 no 782 0.253793706855252 291 16667744 Haematoxylin. SGTC_1510 1123-0200 71.5 µM 0.662276051885894 0.226200137557077 no 783 0.25389716088915 302 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_3040 9091894 49.47 µM 0.66218078207996 0.226233804629442 no 784 0.253927684519743 249 25236966 SGTC_2078 5212016 200 µM 0.66167475756024 0.226412674358148 no 785 0.254089842719531 288 1899708 SGTC_2049 5262831 67.185 µM 0.659904302047536 0.227039123752243 no 786 0.254657621650056 283 763417 SGTC_2644 guaiazulene 100 µM 0.65983472293795 0.227063763229645 no 787 0.254679948990415 271 3515 A coloring agent. SGTC_1520 flindersine 88 µM 0.658223032710502 0.227634919571752 no 788 0.255197413329442 292 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_77 0828-0286 12.516 µM 0.656845803556881 0.228123627034679 no 789 0.25564003463619 275 745345 SGTC_1678 st019265 80.2 µM 0.656734745710303 0.228163061414975 no 790 0.255675744464011 284 5367020 SGTC_1870 st057514 26.5 µM 0.65549515769962 0.228603473929433 no 791 0.256074501528029 287 5393161 SGTC_561 1550-0330 72.9 µM 0.654811437405788 0.22884659667395 no 792 0.256294582919876 288 6812934 SGTC_1997 st073024 93.8 µM 0.653111134876656 0.229451832652988 no 793 0.256842317150389 281 686268 SGTC_2076 5212012 200 µM 0.652638585034081 0.229620199626172 no 794 0.256994652128345 281 604802 SGTC_1923 st058458 19.1 µM 0.652605631560034 0.229631943352971 no 795 0.257005277028823 315 3534982 SGTC_1277 0873-0036 22 µM 0.652256850343321 0.229756260167847 no 796 0.25711774551294 285 5965735 SGTC_3226 9131256 49.47 µM 0.651578507136843 0.229998151344896 no 797 0.257336558295479 254 17178073 SGTC_114 0364-0001 490.298 µM 0.651520359755869 0.230018892815818 no 798 0.257355319365389 288 4003655 SGTC_2171 5739187 198.077 µM 0.651515893846263 0.230020485872109 no 799 0.257356760306493 273 2262761 SGTC_1004 4084-0029 199 µM 0.650427934530038 0.230408761039562 no 800 0.257707919005563 279 716894 YLR208W SEC13 SGTC_3103 9120822 49.47 µM 0.644893521890039 0.232389566328527 no 801 0.259498095042287 306 17141819 SGTC_644 1498-1197 63.3 µM 0.64476913428092 0.232434194099415 no 802 0.259538403459693 284 6741615 SGTC_480 am 92016 50 µM 0.643535337660585 0.232877113523018 no 803 0.259938396343182 322 2129 K+ channel blocker. SGTC_3293 9120939 62.045 µM 0.641644861962744 0.233556682230449 no 804 0.260551898714608 299 934087 SGTC_319 1348-1596 45.5 µM 0.640063591182896 0.234125944759622 no 805 0.261065629019622 305 5380505 SGTC_869 0564-0080 44.1 µM 0.639934018232857 0.234172625469713 no 806 0.261107748328329 275 6843321 SGTC_2626 ethyl orsellinate 100 µM 0.639620518741194 0.234285589947987 no 807 0.261209669707774 307 75653 A natural product. SGTC_731 3966-0296 387 µM 0.639183558203322 0.234443091928561 no 808 0.261351763431676 274 660956 SGTC_814 3342-0569 96 µM 0.638382488499492 0.234731988776449 no 809 0.261612363659729 299 4346283 SGTC_2608 thymoquinone 42.66 µM 0.637213130747545 0.235154057729538 no 810 0.26199301291342 291 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_2597 laccaic acid a 100 µM 0.636766987298655 0.23531519950678 no 811 0.26213831629288 296 5491415 A textile dye. SGTC_109 0132-0036 33.701 µM 0.636109688500078 0.235552719140859 no 812 0.262352465560596 262 67274 A color developer. SGTC_2140 5586273 200 µM 0.633656719450655 0.236440283869142 no 813 0.263152438100962 288 854421 SGTC_1655 st012546 55.1 µM 0.633149319941039 0.236624107167007 no 814 0.263318068773989 301 720985 YLR208W SEC13 SGTC_2035 5154463 94.595 µM 0.631814392240439 0.237108106955501 no 815 0.263754084009085 301 2769623 SGTC_152 4469-0003 551.229 µM 0.631810253365151 0.237109608417573 no 816 0.263755436424435 286 697280 SGTC_1579 chlormadinone acetate 49.4 µM 0.629568434501103 0.237923641581069 no 817 0.264488490611823 316 45114258 A steroidal progestin. SGTC_2389 9091542 195.52 µM 0.629027892206965 0.238120148439675 no 818 0.264665397980413 290 3626624 YOL127W RPL25 SGTC_285 1486-1325 46 µM 0.628964505145685 0.238143197775573 no 819 0.264686147085503 300 22310230 SGTC_1043 0916-0009 19.3 µM 0.628354539098411 0.238365061230952 no 820 0.264885855496052 316 3101130 SGTC_1948 st076329 66.6 µM 0.627690003619663 0.238606902054649 no 821 0.265103517569294 295 24208413 SGTC_484 loperamide 105 µM 0.62604693179486 0.239205432420391 no 822 0.26564207933703 272 3955 An opioid-receptor agonist. SGTC_525 k781-2675 26.7 µM 0.625663327279617 0.239345288076813 no 823 0.265767896058328 291 3651118 YDL195W SEC31 SGTC_598 3937-0236 20.2 µM 0.624797145958037 0.239661247221206 no 824 0.266052102047228 309 1379313 SGTC_2670 beta-carotene 100 µM 0.621851279723996 0.240737519882132 no 825 0.267019831830283 262 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_2978 9011784 42.97 µM 0.620609316751879 0.241192058235017 no 826 0.267428354061557 290 2994934 SGTC_875 0709-0210 25.7 µM 0.620517176144089 0.241225798784492 no 827 0.267458674676763 298 6251364 SGTC_3034 9090421 49.47 µM 0.619464135607587 0.241611589032073 no 828 0.267805320729785 282 17173761 SGTC_2763 lisinopril 49.32 µM 0.619099114121321 0.241745395863267 no 829 0.267925533446915 297 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_2918 7977171 22.06 µM 0.617813128478841 0.242217123086893 no 830 0.268349264174703 298 2236483 SGTC_3311 9131146 2.8755 µM 0.615739684687456 0.242978756549207 no 831 0.269033170501545 308 4900406 YPR165W RHO1 SGTC_3058 9093861 49.47 µM 0.611360004231575 0.244591784104703 no 832 0.270480637352139 309 17217477 SGTC_1231 0242-0792 125 µM 0.61119186897488 0.244653822728315 no 833 0.270536282845109 305 3707635 SGTC_1871 st057448 67.3 µM 0.608058147832661 0.2458116537751 no 834 0.271574454400462 326 691747 SGTC_524 r073-0010 27.8 µM 0.607087837483743 0.246170754477386 no 835 0.271896310625264 320 2772106 SGTC_2144 5628481 200 µM 0.605572539396333 0.246732111127711 no 836 0.272399320958723 294 2818399 SGTC_1714 st033236 13.627 µM 0.604092408730864 0.247281100727264 no 837 0.272891103140455 308 2916566 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.603360832992634 0.247552687659922 no 838 0.273134336008605 312 689007 SGTC_2412 st077135 33.4 µM 0.603018320949253 0.247679895059276 no 839 0.273248250654876 323 13258915 SGTC_2357 9067248 200 µM 0.600955571640155 0.248446728303766 no 840 0.273934789082674 318 9150235 SGTC_1512 0259-0544 12.2 µM 0.600205402684504 0.248725919279839 no 841 0.274184676740055 294 18476 SGTC_3012 9080433 71.4286 µM 0.600069119260708 0.248776657916862 no 842 0.274230085989475 323 17688859 SGTC_545 4218-0007 221 µM 0.598160816039943 0.249487702135177 no 843 0.274866317022857 320 2840508 SGTC_817 1391-0715 46 µM 0.597005092966181 0.2499188553674 no 844 0.275251990154777 333 1353946 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.596891265594516 0.24996134110852 no 845 0.27528998957564 324 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_2888 9058547 12.99 µM 0.596685852760104 0.250038020560278 no 846 0.275358569850437 286 16476514 SGTC_2226 7298446 200 µM 0.595923145825631 0.250322843922193 no 847 0.275613284980674 310 3283010 SGTC_2748 diazoxide 86.69 µM 0.595820850180063 0.250361058028958 no 848 0.275647456647805 266 3019 A potassium channel activatior. SGTC_3175 9106517 49.47 µM 0.594910504223657 0.250701267887017 no 849 0.275951647710243 326 41468073 SGTC_1402 3909-7673 35.9 µM 0.594700068523085 0.250779945670792 no 850 0.276021988014127 292 5328014 SGTC_671 0560-0003 407 µM 0.594604031287169 0.250815856455111 no 851 0.276054092376703 289 3238678 SGTC_1323 1348-1351 11.2 µM 0.594364381574363 0.250905479497604 no 852 0.276134213061397 304 6989654 SGTC_2255 7941087 197.44 µM 0.594029565942819 0.251030720608685 no 853 0.276246169120927 303 935561 SGTC_756 0508-1999 28.3 µM 0.592521487524581 0.251595242086354 no 854 0.276750718155151 319 6753853 SGTC_2360 9040895 200 µM 0.592325226880974 0.251668757942236 no 855 0.276816413123599 289 4914414 SGTC_3003 9075612 71.4286 µM 0.591073130611865 0.252138038585201 no 856 0.277235711132794 324 6501993 SGTC_10 0279-0212 42.575 µM 0.590924879193023 0.252193633164662 no 857 0.277285377657686 288 39851 YBR002C RER2 SGTC_3153 9100258 49.47 µM 0.590476159619611 0.252361943292704 no 858 0.277435732188492 328 25236848 SGTC_2492 derrusnin 100 µM 0.590311125309765 0.252423860866414 no 859 0.277491041016279 323 1715307 Part of coumarin class of compounds. SGTC_2928 9011484 9.79 µM 0.589830257168303 0.252604318621629 no 860 0.27765222764021 301 2994751 SGTC_934 2950-0684 338 µM 0.589161471837685 0.252855409923399 no 861 0.277876479971124 314 1121253 SGTC_3348 9149464 3.537 µM 0.588519431067978 0.253096583694458 no 862 0.278091847654525 294 1951442 SGTC_2661 dactinomycin 12.96 µM 0.588245093140621 0.253199671844209 no 863 0.278183897044409 301 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_2742 clothiapine 36.27 µM 0.58690858924523 0.253702206472893 no 864 0.27863255041933 303 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_1505 k297-0037 20.6 µM 0.586328393976909 0.253920526800287 no 865 0.27882742682619 294 4089396 SGTC_2004 4023728 41.89 µM 0.585644358211306 0.254178047616745 no 866 0.279057266418911 327 360084 YDR527W RBA50 SGTC_2150 5556613 200 µM 0.585414024505617 0.254264792791876 no 867 0.279134680477535 329 743190 SGTC_323 4013-0906 34.3 µM 0.585005759085505 0.25441858633983 no 868 0.279271922184522 281 2910086 SGTC_3240 9133527 49.47 µM 0.583907455294171 0.254832559131984 no 869 0.279641288520375 332 17617455 SGTC_312 4092-0653 6.84 µM 0.583252077522912 0.255079752063476 no 870 0.279861809007457 306 1148278 SGTC_1157 4092-0394 27.6 µM 0.580820838121948 0.255997852337357 no 871 0.280680604650546 298 3659885 SGTC_1610 st001799 48.1 µM 0.580513242694738 0.256114131234114 no 872 0.280784279518219 304 621897 SGTC_1744 st037937 38.9 µM 0.580041511301751 0.256292511201147 no 873 0.280943312288672 311 1016152 SGTC_2330 7979373 200 µM 0.579973649961138 0.256318177537728 no 874 0.280966193671079 285 1863007 SGTC_2015 5119600 184 µM 0.579940026292862 0.256330895088856 no 875 0.280977531181467 324 2828786 SGTC_1162 k048-0130 20.1 µM 0.575797919025576 0.257900085233468 no 876 0.282375890139083 328 6797406 SGTC_530 4358-1714 28 µM 0.574418342232324 0.258423826457787 no 877 0.282842371839598 305 1564641 SGTC_839 0122-0028 230 µM 0.573194173284622 0.258889029772518 no 878 0.283256614565681 336 759448 SGTC_3306 9127676 59.7925 µM 0.572627284024827 0.259104603220655 no 879 0.283448540988087 292 41905287 SGTC_1034 k072-0165 12.7 µM 0.572210727771084 0.25926306801648 no 880 0.283589610282342 338 5835461 SGTC_1160 4092-0570 10.5 µM 0.572120965369122 0.259297221656845 no 881 0.283620013267203 306 4994975 SGTC_1185 1319-0113 81.3 µM 0.571830654767746 0.2594076976736 no 882 0.283718353643635 322 4672763 SGTC_69 0096-0274 206.684 µM 0.570634701169609 0.259863067154772 no 883 0.284123645393041 333 6741392 SGTC_1382 3002-2117 298 µM 0.569581366699605 0.260264474470716 no 884 0.284480834712364 344 1497314 SGTC_347 4534-1311 26.2 µM 0.56804845692806 0.260849209824669 no 885 0.285001032561497 305 2862016 SGTC_1085 doxorubicin 7.67 µM 0.567685429482166 0.260987787187186 no 886 0.285124293489017 332 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.567400910242668 0.261096422304989 no 887 0.285220915803817 290 6708739 YPR165W RHO1 SGTC_3014 9081533 49.47 µM 0.566746089198019 0.261346534312053 no 888 0.285443351323774 355 21367265 SGTC_1980 st071811 45.7 µM 0.566434613994838 0.261465546920821 no 889 0.285549185011822 327 4974850 SGTC_1984 st072354 53.1 µM 0.566214996316468 0.261549478103525 no 890 0.285623818385981 320 5762938 SGTC_895 0964-0006 13.7 µM 0.56552913339326 0.261811683019283 no 891 0.285856957106617 333 6738897 SGTC_1737 st035557 69.7 µM 0.564799291397231 0.262090849107891 no 892 0.286105144536189 322 5716916 SGTC_950 1165-0508 94.1 µM 0.564262020484233 0.262296453802476 no 893 0.286287912335078 321 6148369 SGTC_478 N-arachidonylglycine 10 µM 0.562166744407523 0.263099069890383 no 894 0.287001208508126 282 5283389 SGTC_1848 st056003 16.4 µM 0.562166295720621 0.263099241898612 no 895 0.287001361345003 295 146492 SGTC_745 0469-0705 296 µM 0.561429694685212 0.263381702105779 no 896 0.28725232280143 333 3486736 SGTC_2630 antimycin a 100 µM 0.559499587124596 0.264122563104189 no 897 0.287910406460518 326 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_2616 abietic acid 100 µM 0.559186269429763 0.264242928427957 no 898 0.288017301443336 323 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_1121 fusaric acid 630.51 nM 0.559086158895247 0.264281393161364 no 899 0.288051460226077 292 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_2752 diclazuril 33.15 µM 0.55828835836537 0.264588028040851 no 900 0.288323746591278 327 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_101 0490-5701 117.494 µM 0.558174717100716 0.264631720817871 no 901 0.288362541806775 324 4661669 SGTC_226 1,3-diallylurea 8.28947 mM 0.55769203566518 0.26481734299622 no 902 0.288527348547017 311 74537 YKL182W FAS1 SGTC_1691 st019933 84.6 µM 0.557593630458688 0.264855194273221 no 903 0.288560953464706 341 6176082 SGTC_2461 5755302 26.15 µM 0.556520304950016 0.265268224317826 no 904 0.288927608798146 348 2788904 SGTC_593 1203-0218 61.7 µM 0.556015432975612 0.265462618841782 no 905 0.289100152296585 336 3666956 SGTC_908 3448-7491 47.7 µM 0.555659375298429 0.265599757765062 no 906 0.289221866607584 280 1203031 SGTC_38 0929-0051 58.268 µM 0.554225121050852 0.266152537756032 no 907 0.289712394068543 335 1379719 SGTC_1047 2043-3044 82 µM 0.553632834453241 0.266380982438253 no 908 0.28991507509313 358 669592 SGTC_2283 7944793 200 µM 0.553185415731895 0.266553617399601 no 909 0.290068226270981 317 2970533 SGTC_1398 3558-0053 112 µM 0.552569079703416 0.26679152113525 no 910 0.290279259825263 313 4532369 SGTC_3284 9108171 64.8615 µM 0.552410780672906 0.266852641369001 no 911 0.290333473042928 319 8687505 SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.551490085127707 0.267208267785963 no 912 0.29064888078272 298 6708630 An antioxidant. SGTC_898 1000-0849 28.3 µM 0.550793076962746 0.267477652061657 no 913 0.290887765255278 324 6751807 SGTC_2592 piperlongumine 83.33 µM 0.548767588886324 0.268261252425543 no 914 0.291582477772829 333 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_44 0929-0055 61.211 µM 0.548211818127228 0.268476465148443 no 915 0.29177323410882 303 1379590 SGTC_1351 1496-0003 46.5 µM 0.547561551851626 0.268728379793419 no 916 0.291996497785242 312 3891978 SGTC_413 propylparaben 100 µM 0.547309208259795 0.268826170251256 no 917 0.292083159338155 307 7175 A pharmaceutical preservative. SGTC_1981 st071826 47 µM 0.547075923953721 0.268916590578839 no 918 0.292163286069293 307 11838600 SGTC_1618 st003135 44.5 µM 0.546690916943208 0.269065851579935 no 919 0.292295547733887 337 1270615 SGTC_1175 0741-0056 27.6 µM 0.546311059460004 0.269213156927789 no 920 0.292426067663925 340 765927 SGTC_2312 7706453 155.7 µM 0.545967074664002 0.269346586061799 no 921 0.292544285026038 323 976098 SGTC_1946 st076057 65.1 µM 0.545743031392995 0.269433508602298 no 922 0.292621293987924 324 953009 SGTC_3263 9137018 49.47 µM 0.541235753165928 0.271185188329271 no 923 0.294172548528538 314 43844957 SGTC_2247 cerulenin 830 nM 0.540735908460639 0.271379793952422 no 924 0.294344812167097 295 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_2189 6047310 154.431 µM 0.540706624800481 0.271391197180742 no 925 0.29435490576558 321 711535 SGTC_1771 st048882 4.1505 µM 0.540407007264668 0.271507883715482 no 926 0.294458188209483 310 4580403 SGTC_730 1436-0052 41.2 µM 0.539912731664176 0.271700434747952 no 927 0.294628608617853 303 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_2083 5306046 65.942 µM 0.539042673399116 0.272039541513258 no 928 0.294928704949741 314 539837 SGTC_3194 9111903 49.47 µM 0.539022189303986 0.272047527761033 no 929 0.294935771922617 359 17087251 SGTC_1256 0570-0116 285 µM 0.538843337479991 0.272117262665867 no 930 0.294997478767829 327 410638 SGTC_779 1360-0071 233 µM 0.538271851894651 0.272340146290438 no 931 0.295194690626607 313 7566 SGTC_2657 nystatin 74.44 µM 0.537026449084114 0.27282617659938 no 932 0.295624672225934 317 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1932 st074806 40.9 µM 0.536957164471873 0.272853228207918 no 933 0.295648601539163 340 17251235 SGTC_922 1866-0035 480 µM 0.535903493527367 0.273264789272059 no 934 0.296012624945396 334 3156169 SGTC_3216 9129716 49.47 µM 0.53524548525038 0.273521961439498 no 935 0.296240058686333 296 8056934 SGTC_2023 5144124 124 µM 0.53269587247537 0.274519567339366 no 936 0.297122061903789 329 2830192 SGTC_2929 9013348 24.6 µM 0.529559253402364 0.275749313228498 no 937 0.298208775855856 334 2995952 SGTC_3033 9090887 49.47 µM 0.529025189795561 0.275958968147337 no 938 0.298393987885698 321 19325384 SGTC_1606 st000094 49.2 µM 0.527880514334159 0.276408591743255 no 939 0.298791134951536 324 1242210 SGTC_1761 st044296 37 µM 0.527532685813263 0.276545288430837 no 940 0.298911862209815 320 1826700 SGTC_2447 5741742 33.78 µM 0.527050767765636 0.276734737083924 no 941 0.299079167001885 319 1776504 SGTC_2737 bleomycin 30.5 nM 0.525856485391419 0.277204499872238 no 942 0.299493962438001 323 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_387 norethindrone acetate 66.7 µM 0.525763061178359 0.277241264091638 no 943 0.299526421318076 336 541197 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.52497526654988 0.277551371199861 no 944 0.299800192457841 338 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_476 mead acid 10 µM 0.523794647265203 0.278016426737542 no 945 0.300210688394565 344 5312531 An omega 9 fatty acid. SGTC_2425 5628681 7.85 µM 0.521906082238703 0.278761137483394 no 946 0.300867861643869 341 5714958 SGTC_1268 0828-0275 2.46 µM 0.520877074535762 0.279167310474337 no 947 0.301226203367829 344 745337 SGTC_2497 7-hydroxyflavone 100 µM 0.518823153385745 0.279978899547211 no 948 0.301942035200841 362 5281894 SGTC_1366 1683-0113 21.9 µM 0.517028440515394 0.280688999927313 no 949 0.302568152749157 326 708623 SGTC_3150 9097574 49.47 µM 0.516364648352682 0.280951858033802 no 950 0.302799875794003 342 17217476 SGTC_1950 st077106 7.18 µM 0.515454719607565 0.281312378099072 no 951 0.303117651667778 313 13831864 SGTC_3019 9081971 49.47 µM 0.512694138653561 0.282407503832626 no 952 0.30408264520195 342 16451803 SGTC_1141 3253-0389 52.6 µM 0.51104416043702 0.283063029740894 no 953 0.304660067413475 351 5402031 SGTC_793 0488-0545 106 µM 0.510441120042526 0.283302795973842 no 954 0.30487122751421 343 292548 SGTC_166 k072-0058 166.424 µM 0.508800770620356 0.283955484092422 no 955 0.305445939597259 346 5846229 SGTC_1944 st076371 56.9 µM 0.508131401504293 0.284222029809409 no 956 0.30568059738339 326 24208455 SGTC_1013 4112-3890 241 µM 0.507317920796103 0.284546122331276 no 957 0.305965883185543 319 705171 SGTC_1511 0906-3109 28.5 µM 0.507317303972372 0.284546368142171 no 958 0.305966099548896 327 2882180 SGTC_2784 7567673 72.73 µM 0.506626923337237 0.284821555813765 no 959 0.306208306899662 346 3471247 SGTC_298 1391-0729 10 µM 0.505891400756989 0.285114876831197 no 960 0.306466444691841 344 3237558 SGTC_2241 6772625 37.8075 µM 0.504842541715736 0.28553340303345 no 961 0.306834716682354 327 2285411 SGTC_3028 9087778 49.47 µM 0.503676960175238 0.285998847799887 no 962 0.307244200708449 331 17217395 SGTC_1500 4488-1866 171 µM 0.502941115444795 0.2862928738724 no 963 0.307502836429327 385 2900003 SGTC_142 0335-0849 62.6745 µM 0.501975609347636 0.286678884729703 no 964 0.307842339045071 319 3889043 YPR107C YTH1 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 0.501525989252733 0.286858727734641 no 965 0.30800049593599 334 390807 SGTC_2906 7926292 26.41 µM 0.50143488327743 0.286895175618191 no 966 0.308032547421923 353 2966319 SGTC_2902 5787006 60.46 µM 0.501091661610404 0.287032504681087 no 967 0.308153307472897 335 591003 SGTC_2814 7977482 42.97 µM 0.50076081650526 0.287164911124477 no 968 0.308269732581357 333 6456762 SGTC_917 harmaline 728.087 nM 0.500610016641282 0.287225271839126 no 969 0.308322805780493 319 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_231 b-estradiol 524 µM 0.499899651495617 0.287509690685126 no 970 0.308572868841237 313 450 A steroid. SGTC_2924 9010168 62.78 µM 0.497080517503858 0.288639737785411 no 971 0.309566136384886 340 2993929 SGTC_2351 9026858 72.31 µM 0.496576904625093 0.288841830554045 no 972 0.309743721488326 357 1409300 SGTC_739 1486-1183 203 µM 0.495376709638494 0.289323720234568 no 973 0.310167115932356 340 4346692 SGTC_2788 5282734 71.43 µM 0.495371093522503 0.28932597604624 no 974 0.310169097729607 357 743706 SGTC_2777 climbazole 1.536 µM 0.495274050674288 0.289364956316642 no 975 0.310203342773707 326 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_1878 temozolomide 1 mM 0.494135032960293 0.289822662458088 no 976 0.310605408932698 341 5394 DNA alkylating agent. SGTC_3213 9129884 49.47 µM 0.494106948217869 0.289833952400547 no 977 0.310615325532937 327 17190742 SGTC_728 3030-5151 22.5 µM 0.493728742359166 0.289986009577968 no 978 0.310748881776667 344 3125388 SGTC_3143 9086658 49.47 µM 0.493196701533381 0.290199979199361 no 979 0.310936804147319 346 25236626 SGTC_2801 7907800 81.82 µM 0.491526223561116 0.290872271689991 no 980 0.311527154718692 348 6620925 SGTC_2186 6124449 200 µM 0.490579801326484 0.29125348698611 no 981 0.311861837684915 343 3834182 YLR033W RSC58 SGTC_2491 paeonol 100 µM 0.49045920532877 0.291302079345223 no 982 0.311904495174833 342 11092 Increases levels of cortical cytochrome oxidase. SGTC_1443 4112-3303 14 µM 0.490186848156382 0.291411835526624 no 983 0.312000843254883 343 704433 SGTC_3076 9116187 49.47 µM 0.489782788589841 0.291574701488882 no 984 0.312143805590681 363 27241210 SGTC_1600 coumarin 106 71.1 µM 0.489266339515642 0.29178293052544 no 985 0.312326574213148 367 100336 A hepatotoxic, DNA x-linker. SGTC_1996 st072960 66.8 µM 0.48855321634576 0.292070571165398 no 986 0.312579020681439 347 1719405 SGTC_1106 tegaserod maleate 11.7 µM 0.487071708258147 0.292668564004162 no 987 0.313103757439689 358 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_1061 3448-9325 110 µM 0.486413127225239 0.292934574753282 no 988 0.313337142552269 361 723482 SGTC_2704 st078022 71.1 µM 0.486255862061447 0.292998113101661 no 989 0.313392884567064 351 54697681 SGTC_2329 6138490 200 µM 0.485832464060505 0.293169206341808 no 990 0.313542977496842 374 720019 SGTC_1200 1643-0193 18.4 µM 0.485782556596057 0.293189376776929 no 991 0.313560671531855 361 5403974 SGTC_3303 9125618 40.5795 µM 0.485675302352102 0.293232726473139 no 992 0.313598698564707 351 22695467 SGTC_1238 0333-0287 48.8 µM 0.485325230140701 0.293374238273912 no 993 0.313722830582655 338 7226 SGTC_3004 9076122 71.4286 µM 0.485151571762834 0.293444448987083 no 994 0.313784415890722 374 44782551 SGTC_2519 cryptotanshinone 88.04 µM 0.484822844908526 0.293577375757042 no 995 0.313901008086849 326 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_324 1315-0088 19.6 µM 0.484180390042897 0.293837244695642 no 996 0.314128926359457 371 6787421 SGTC_861 0443-0273 110 µM 0.48413894571243 0.293854012318826 no 997 0.314143631649073 349 6149169 SGTC_2936 9038235 15.59 µM 0.483357215478693 0.294170369044814 no 998 0.31442106065222 325 4749415 SGTC_3237 9133362 49.47 µM 0.482971193171302 0.294326645600712 no 999 0.314558095162893 363 43845137 SGTC_2390 9097792 176.6 µM 0.482612543790415 0.294471874899875 no 1000 0.314685435423978 329 4497149 SGTC_973 1325-0077 65.9 µM 0.481529153363985 0.294910777165505 no 1001 0.315070232440068 357 2835149 SGTC_2082 5219693 150 µM 0.480760344345253 0.295222419218785 no 1002 0.315343418718671 330 2834649 SGTC_48 0382-0018 55 µM 0.480731850252439 0.29523397240928 no 1003 0.315353545665338 309 762596 SGTC_2920 7982904 15.77 µM 0.480606409353785 0.295284836043391 no 1004 0.315398129653319 348 6456808 SGTC_2020 4017018 200 µM 0.480317594619961 0.295401959645403 no 1005 0.315500789906113 357 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_2884 9058502 51.95 µM 0.476236797895328 0.297059132460184 no 1006 0.316952843227453 334 6471554 SGTC_93 0109-0045 59.227 µM 0.476194933860942 0.29707615505843 no 1007 0.31696775420637 337 88733 SGTC_2693 st077581 40.7 µM 0.475860428702548 0.297212186322837 no 1008 0.317086907707481 354 25238761 SGTC_501 nsc-95397 161 µM 0.475533469964663 0.29734517623574 no 1009 0.317203391442379 358 262093 SGTC_935 2996-0153 430 µM 0.473281502748619 0.298261897621962 no 1010 0.318006178506175 353 23738523 SGTC_2291 7917025 104.35 µM 0.473033889328677 0.298362773538733 no 1011 0.318094500671725 337 2964612 SGTC_3265 9137266 49.47 µM 0.472492656044638 0.298583322116223 no 1012 0.318287591230665 336 17224265 SGTC_692 k241-0027 77.8 µM 0.472330566612721 0.298649386791137 no 1013 0.318345427919687 356 3600480 SGTC_778 3456-2434 196 µM 0.47221458561225 0.298696662595453 no 1014 0.318386814933761 319 5539063 SGTC_1978 st071761 42 µM 0.470817492553866 0.299266408322918 no 1015 0.318885535866383 332 5147680 SGTC_2743 auranofin 4.32 µM 0.47050439221253 0.299394160745102 no 1016 0.318997348473669 304 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_1216 1165-0504 9.65 µM 0.469676351651661 0.299732140208477 no 1017 0.319293132960879 354 6304004 SGTC_2767 sibutramine 71.45 µM 0.468747046428361 0.30011165829891 no 1018 0.319625227227661 368 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_625 k213-0058 121 µM 0.468592030079866 0.300174986425658 no 1019 0.31968063758232 346 3655420 SGTC_2701 st077767 14.721 µM 0.464563648531945 0.301822797017466 no 1020 0.321121984725047 353 5721188 SGTC_2678 equilin 100 µM 0.463840080758776 0.302119202802116 no 1021 0.321381162438787 333 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_2575 plumbagin 510 nM 0.463754891558433 0.302154108713215 no 1022 0.321411682434982 337 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_581 0958-0271 211 µM 0.462878803439647 0.302513187067753 no 1023 0.32172562086037 332 4591145 SGTC_1687 st020778 55.3625 µM 0.462754432089059 0.302564178104616 no 1024 0.321770198559234 337 4259299 SGTC_846 0335-0850 148 µM 0.461586691518925 0.303043128075306 no 1025 0.322188870071476 351 6819598 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.460948489376256 0.303305030597615 no 1026 0.322417780922207 363 6710655 SGTC_2411 st077133 39.94 µM 0.459176324504731 0.304032813565789 no 1027 0.323053775363981 377 1403142 YNL221C POP1 SGTC_1866 st057638 64 µM 0.458858137762226 0.304163567143565 no 1028 0.323168021076882 346 688802 SGTC_212 3807-4682 38.772 µM 0.458589861006103 0.304273830501223 no 1029 0.323264359451563 351 3125501 YBL034C STU1 SGTC_3061 glucosamine 200 µM 0.456564514931185 0.305106833709782 no 1030 0.323992044811091 346 91431 and experimental redox chemotherapeutic SGTC_3180 9109287 49.47 µM 0.454660894757677 0.305890694018154 no 1031 0.324676609116561 345 18891271 SGTC_2263 7948595 193.29 µM 0.453612305013196 0.306322855863166 no 1032 0.325053947685259 371 2971371 SGTC_1182 1222-0449 220 µM 0.453412100301614 0.306405398148528 no 1033 0.325126012448738 354 658318 SGTC_447 ml7 120 µM 0.453061239100126 0.306550078205295 no 1034 0.325252322603904 379 4216 Selective myosin light chain kinase inhibitor. SGTC_3283 9109332 35.8195 µM 0.452614447938487 0.306734359296449 no 1035 0.325413196642443 326 17027281 SGTC_2444 5485484 36.41 µM 0.452169003152929 0.306918133710288 no 1036 0.325573618286547 374 6790631 SGTC_2843 9000894 45.46 µM 0.450497046382233 0.307608355258755 no 1037 0.32617604171217 318 2242070 SGTC_469 w7 172 µM 0.450041705844998 0.30779644832251 no 1038 0.326340184347405 360 45115570 A P450 inhibitor. SGTC_1787 fluconazole 80 µM 0.449727380305987 0.307926320081436 no 1039 0.326453513065992 335 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_1886 st057356 49.9 µM 0.44967757679197 0.307946899905247 no 1040 0.326471470978952 349 24207747 SGTC_3270 9137563 49.47 µM 0.449461010580753 0.308036396486909 no 1041 0.326549564064257 351 17015724 SGTC_791 1348-1292 225 µM 0.448345962682153 0.308497373724754 no 1042 0.326951767048308 355 5437054 SGTC_547 1120-0019 610 nM 0.446690996841241 0.309182117710254 no 1043 0.327549091614922 348 3676939 SGTC_2738 aclarubicin 5.55 µM 0.445885556151068 0.309515609856825 no 1044 0.327839958115531 332 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_1370 2001-0092 44.6 µM 0.445128464850653 0.309829226058339 no 1045 0.328113459601176 374 790957 SGTC_1481 3346-2004 36 µM 0.444337640459623 0.310156963653455 no 1046 0.328399245703244 386 2770522 SGTC_3164 9100705 49.47 µM 0.443472224856151 0.310515786606643 no 1047 0.328712102480481 366 17174235 SGTC_3162 9099653 49.47 µM 0.442524229211638 0.310909056331122 no 1048 0.329054950627806 336 25237511 SGTC_1094 duloxetine 25.4 µM 0.442035638541601 0.311111829348882 no 1049 0.32923170848406 331 60834 A selective serotonin reuptake inhibitor. SGTC_2369 9071472 200 µM 0.441302343361773 0.311416266300352 no 1050 0.329497064935466 350 17296037 SGTC_1927 st060202 13.8 µM 0.44129986519859 0.311417295360586 no 1051 0.329497961850421 355 688887 SGTC_1630 st005209 31.3 µM 0.439846339946043 0.312021127115635 no 1052 0.330024201207102 364 3367314 SGTC_2428 5615643 7.78 µM 0.439272679526788 0.312259579609234 no 1053 0.330231983900771 393 2253075 SGTC_1317 1273-0028 910 nM 0.439176652314386 0.312299502772653 no 1054 0.330266770558919 357 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_1657 st012939 43.4 µM 0.438988403465972 0.312377773331519 no 1055 0.330334969530262 355 24207257 SGTC_2453 5731132 22.18 µM 0.438333004593545 0.312650342681959 no 1056 0.330572452012449 372 1362040 SGTC_3055 9094636 49.47 µM 0.437484621781004 0.313003323000889 no 1057 0.330879963160998 349 25236176 SGTC_2997 9067075 71.4286 µM 0.437052334467073 0.313183247531859 no 1058 0.331036697152268 392 27209819 SGTC_3118 9124250 49.47 µM 0.436322275425717 0.313487210158242 no 1059 0.331301461177144 384 1504786 SGTC_2099 5377090 177.372 µM 0.436111928406372 0.313574812394668 no 1060 0.331377761519501 363 2243829 SGTC_250 brefeldin a 552.239 µM 0.434107168947807 0.314410252255065 no 1061 0.332105309924647 373 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_1809 st050081 57.6 µM 0.432790738872206 0.314959363642585 no 1062 0.332583401012163 383 5036894 SGTC_831 k061-1017 217 µM 0.432143075079643 0.315229668471269 no 1063 0.332818714675751 385 1240153 SGTC_3064 1327-0027 10 µM 0.428052692917847 0.31693908527979 no 1064 0.334306378829025 374 16000455 YPR107C YTH1 SGTC_483 fpl-64176 144 µM 0.428031471562052 0.316947964162259 no 1065 0.334314103810913 384 3423 SGTC_1667 st014849 34.6 µM 0.427457346206888 0.317188214607778 no 1066 0.334523123107772 349 5348460 SGTC_1287 0971-0001 34.6 µM 0.427205785140322 0.317293507994018 no 1067 0.334614724008106 349 4665869 SGTC_167 3672-0051 66.205 µM 0.427124753953437 0.317327427552719 no 1068 0.334644231980771 377 3237971 SGTC_2827 7993847 71.43 µM 0.426893606332845 0.317424194102375 no 1069 0.334728411327391 370 2985692 SGTC_526 4469-0568 170 µM 0.426223865230579 0.317704641801059 no 1070 0.334972364550208 368 2901964 SGTC_926 2268-1401 59.4 µM 0.426023532045912 0.317788549747144 no 1071 0.335045349457177 359 2931578 SGTC_2898 9056270 58.44 µM 0.424685404884214 0.318349253405284 no 1072 0.335533012396243 358 19154699 SGTC_57 miconazole 162.5 nM 0.424344149915196 0.318492313161123 no 1073 0.335657422695996 369 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_66 0109-0187 42.4 µM 0.422629951746978 0.319211342629957 no 1074 0.336282635097918 338 759417 SGTC_154 3389-1638 511.116 µM 0.421018163352037 0.31988803673171 no 1075 0.336870909350932 396 5238686 SGTC_2927 9011802 47.9 µM 0.419414595129519 0.320561874994444 no 1076 0.337456579672518 356 43912568 SGTC_2867 9039098 71.43 µM 0.418461001991117 0.320962866850912 no 1077 0.337805046868587 374 6463460 SGTC_2077 5212015 200 µM 0.417136564448217 0.321520147611884 no 1078 0.338289260718214 368 780900 SGTC_2848 9016370 25.97 µM 0.417103536323157 0.321534049927128 no 1079 0.338301339210471 361 7894410 SGTC_2366 9070441 60.58 µM 0.416942062246239 0.321602021764869 no 1080 0.338360393198313 353 6837235 SGTC_1959 st077091 55.8 µM 0.416301826965026 0.321871584900224 no 1081 0.338594577932447 368 821356 YKL052C ASK1 SGTC_3269 9137823 49.47 µM 0.416140871726086 0.321939367865759 no 1082 0.338653461830019 358 17682936 SGTC_515 4092-1064 102 µM 0.414697003454337 0.322547687829612 no 1083 0.339181863133139 393 717353 SGTC_684 1140-0066 328 µM 0.414657320780939 0.322564413360668 no 1084 0.339196389966944 355 6813534 SGTC_1717 st033143 58.0435 µM 0.412467242963135 0.323488047614665 no 1085 0.339998492764419 403 674616 SGTC_1805 st050013 60.3 µM 0.411586079147101 0.323859973412408 no 1086 0.340321418380897 378 4037144 SGTC_1441 4106-0040 13 µM 0.410094830639521 0.324489807342019 no 1087 0.340868192308927 362 2904180 SGTC_3082 9117008 49.47 µM 0.409354529941443 0.324802662595544 no 1088 0.341139751666405 361 41448529 SGTC_204 PMA1.184 62.41 µM 0.409071038662849 0.324922500356198 no 1089 0.341243764601981 364 2252213 YGL008C PMA1 SGTC_2896 9052656 71.43 µM 0.408222218972112 0.325281422697425 no 1090 0.34155526860643 372 6469436 SGTC_2452 5863136 48.41 µM 0.407434526693434 0.325614642452069 no 1091 0.341844436353294 362 2184096 SGTC_1440 4100-1550 40 µM 0.407432973905961 0.325615299470025 no 1092 0.341845006484945 388 742806 SGTC_2262 9014885 67.46 µM 0.404769800326416 0.326742941607175 no 1093 0.342823364642581 379 6457424 SGTC_1103 duloxetine 36.1 µM 0.404007933169238 0.327065823660493 no 1094 0.343103442737545 376 60835 A selective serotonin reuptake inhibitor. SGTC_3340 9146634 11.102 µM 0.403713893486399 0.32719047338456 no 1095 0.3432115608625 382 4907387 SGTC_39 0986-0283 58.349 µM 0.40241840266468 0.327739889109685 no 1096 0.343688064407915 347 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_2128 5255449 168.493 µM 0.402280595932907 0.327798354716017 no 1097 0.343738766699855 335 736008 SGTC_232 clozapine 119 µM 0.401429354569797 0.3281595941876 no 1098 0.344052020411395 380 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_3204 9114183 49.47 µM 0.39887068291996 0.329246378980653 no 1099 0.344994246010088 346 17027248 SGTC_1217 1183-1422 255 µM 0.398459155714049 0.3294213084712 no 1100 0.345145880011813 374 2849664 SGTC_2172 5754775 163.918 µM 0.398347399176493 0.329468819711321 no 1101 0.345187062849725 367 2263357 SGTC_130 0136-0219 337.655 µM 0.398002830839352 0.329615323940783 no 1102 0.345314049528378 404 234244 SGTC_286 k060-0067 22.9 µM 0.397693683499107 0.329746790060912 no 1103 0.345427997030896 347 5985051 SGTC_3133 9127736 49.47 µM 0.396800988192698 0.330126530279113 no 1104 0.345757110978577 381 27243420 SGTC_2977 9011197 71.43 µM 0.395458959882414 0.330697739877663 no 1105 0.346252101858629 413 2704722 SGTC_842 0271-0008 11.1 µM 0.395420752130913 0.330714008084148 no 1106 0.346266198175393 358 1221709 SGTC_1896 st058441 89 µM 0.394499154811534 0.3311065052633 no 1107 0.346606275540371 352 688759 SGTC_3313 9133968 57.047 µM 0.394162272585085 0.331250025699552 no 1108 0.346730618866627 384 1494643 SGTC_1698 5-fluorocytosine 1.055 µM 0.393360885082102 0.331591536853095 no 1109 0.347026477561396 383 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2952 9073731 13.78 µM 0.390132435180882 0.33296875628583 no 1110 0.34821930977593 344 16457353 SGTC_1649 st011737 51.3 µM 0.389796043791048 0.333112387069789 no 1111 0.348343684719467 373 1761035 SGTC_374 0880-0231 82.3 µM 0.388827468551051 0.333526081358663 no 1112 0.348701889837905 393 6833587 SGTC_2972 9093619 59.92 µM 0.388176817716168 0.333804098703576 no 1113 0.348942593760335 336 25236256 SGTC_2749 bexarotene 57.39 µM 0.385352799882072 0.335011832547162 no 1114 0.349988023787841 364 82146 An retinoic acid receptor inhibitor. SGTC_575 k072-0246 11.9 µM 0.3853299312938 0.335021619632175 no 1115 0.349996494221956 381 6796779 SGTC_1378 2093-0007 380 nM 0.385293579765086 0.335037177250794 no 1116 0.350009958837192 417 3618014 SGTC_1825 st052143 62.6 µM 0.38503100807173 0.33514956030394 no 1117 0.35010722105721 383 674173 SGTC_881 0833-0569 170 µM 0.384898570714295 0.335206250287442 no 1118 0.3501562824428 354 5418700 SGTC_2968 9090663 33.37 µM 0.383646553450914 0.335742363226373 no 1119 0.350620215398772 418 25236811 SGTC_2570 licareol 100 µM 0.382739277440085 0.336131067282109 no 1120 0.350956544365275 369 443158 SGTC_2467 5474540 200 µM 0.381684246479829 0.336583294375675 no 1121 0.351347793254729 358 5413519 SGTC_345 1362-0200 395 µM 0.380955869288414 0.336895643041267 no 1122 0.351617997459939 363 1419823 SGTC_727 3032-0951 202 µM 0.380704634743018 0.337003405602845 no 1123 0.351711214689462 397 3652836 SGTC_14 0354-0009 295 µM 0.380636621047388 0.337032581161844 no 1124 0.351736451798555 397 1713507 SGTC_2107 5363541 170.161 µM 0.379778030341309 0.337400971586778 no 1125 0.352055095949702 385 244052 SGTC_2676 harmalol 100 µM 0.379441811616273 0.33754527346424 no 1126 0.352179903322644 374 5459187 A monoamine oxidase inhibitor SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.378143658900976 0.338102652300546 no 1127 0.352661938446838 373 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_2198 6589944 200 µM 0.374750201149382 0.33956135241647 no 1128 0.353923126652159 366 5290268 SGTC_3030 9087619 49.47 µM 0.373479317981063 0.340108270544618 no 1129 0.354395867727011 380 25236973 SGTC_392 N-ethylmaleimide 8.33 µM 0.37333245992577 0.340171491881334 no 1130 0.354450510228587 357 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_2405 ticlatone 3.52 µM 0.370836063074375 0.341246858923923 no 1131 0.355379819513724 324 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_1889 st059080 5.18 µM 0.369728976492723 0.341724169623166 no 1132 0.355792219613064 374 176925 Isolated from Daphnopsis sellowiana. SGTC_117 lucigenin 22.078 µM 0.368546818345111 0.342234126272452 no 1133 0.356232770962107 400 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_2025 5147754 141 µM 0.368530818007217 0.342241030437544 no 1134 0.356238735078287 388 315777 YLR208W SEC13 SGTC_86 0417-1630 471.922 µM 0.364749123580935 0.343874310746086 no 1135 0.357649342894786 381 3634867 SGTC_621 3584-0052 32.1 µM 0.364364425537325 0.344040622434078 no 1136 0.357792948309778 411 2273927 SGTC_2523 spermine 47.74 µM 0.363990883096604 0.344202140235865 no 1137 0.357932408670408 369 1103 A DNA binding polyamine. SGTC_504 lovastatin 124 µM 0.363493896817355 0.344417078571718 no 1138 0.358117985619013 407 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_1177 0983-0204 23.6 µM 0.363290502071184 0.344505057926811 no 1139 0.358193943817817 387 766818 SGTC_382 3229-0966 23.2 µM 0.361424267025611 0.345312698877594 no 1140 0.358891154921338 397 5722370 SGTC_711 k292-0785 179 µM 0.361160083821318 0.345427085125064 no 1141 0.35898988979998 379 4146315 SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.360678063116479 0.345635827195495 no 1142 0.359170062752842 402 5282309 SGTC_2583 asiatic acid 100 µM 0.359963497062029 0.345945360842022 no 1143 0.359437215707321 417 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_771 0250-0039 27.3 µM 0.359243515209932 0.346257344644409 no 1144 0.359706462960288 415 3005115 SGTC_765 1319-0117 244 µM 0.358102725695445 0.346751887169675 no 1145 0.36013321966563 378 3487746 YGL099W LSG1 SGTC_24 0417-1663 219 µM 0.35728844376228 0.347105045557045 no 1146 0.360437940188573 396 4329390 SGTC_1357 1503-1303 39.5 µM 0.356408336553275 0.347486902083023 no 1147 0.360767393543366 372 292895 SGTC_407 eburnamonine 100 µM 0.355403088905055 0.347923243320914 no 1148 0.361143817554843 371 3195 SGTC_1273 0849-0096 14.1 µM 0.355187373306837 0.348016903846751 no 1149 0.361224611738594 403 5286025 SGTC_1186 1319-0216 26 µM 0.354660324660256 0.348245779577246 no 1150 0.36142203872762 384 4565136 SGTC_2177 5811945 192 µM 0.354322996237116 0.348392296570312 no 1151 0.361548417850269 416 5343475 SGTC_2999 9069765 71.4286 µM 0.353489409771509 0.348754457874719 no 1152 0.36186078338134 398 2097066 SGTC_3101 9120531 49.47 µM 0.353224585363602 0.348869542780334 no 1153 0.361960038935078 427 24824904 SGTC_471 1-acyl-paf 4 µM 0.352405302109175 0.349225667218496 no 1154 0.362267163105002 369 16759367 SGTC_27 0485-0001 32.618 µM 0.351944397289512 0.349426070811746 no 1155 0.362439981180315 399 2054479 SGTC_88 0180-0332 8.668 µM 0.351752987278024 0.349509309129463 no 1156 0.36251175935805 367 3101745 SGTC_1746 st038117 42 µM 0.350608504372841 0.350007160363816 no 1157 0.362941037759818 395 2898218 SGTC_2847 9005661 71.43 µM 0.349641793042147 0.350427881780795 no 1158 0.363303770950878 401 2991449 SGTC_461 N-acetylfarnesylcysteine 136 µM 0.349574652312808 0.350457108849983 no 1159 0.363328968314387 414 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.347662910544948 0.35128968117507 no 1160 0.364046677053904 376 2333 A French combination drug. SGTC_3315 9136395 68.55 µM 0.347578304411357 0.351326544065841 no 1161 0.364078451048913 436 16876844 SGTC_3252 9135871 49.47 µM 0.346028559740343 0.352002014911522 no 1162 0.36466062572677 405 17682838 SGTC_1016 4226-1401 38 µM 0.344898153821194 0.352495007882412 no 1163 0.365085469293191 380 2901613 SGTC_1832 st054113 55 µM 0.344717393657987 0.352573864069234 no 1164 0.365153420258904 407 1251267 SGTC_1735 st034310 56.75 µM 0.344545947993095 0.352648662683268 no 1165 0.365217873651363 439 871153 SGTC_746 1095-0025 46.6 µM 0.343803705199099 0.352972555356358 no 1166 0.365496956781857 422 6749286 SGTC_1430 4049-0248 69.1 µM 0.343018952013033 0.353315114197945 no 1167 0.365792101270826 410 22774488 SGTC_3052 9092717 49.47 µM 0.342625429885092 0.353486938434331 no 1168 0.365940134272579 393 25237534 SGTC_3139 9095020 49.47 µM 0.341507361512868 0.353975285374797 no 1169 0.366360831970663 391 25236292 SGTC_550 4123-0385 25.7 µM 0.340903209251841 0.354239265463125 no 1170 0.366588224376225 391 5731123 SGTC_1553 gossypol 38.6 µM 0.339356569674706 0.354915377741238 no 1171 0.367170565878559 426 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2817 7995342 71.43 µM 0.338751541499225 0.355179989853317 no 1172 0.367398454647634 380 18879975 SGTC_1267 0828-0272 9.49 µM 0.336111286891887 0.356335534478296 no 1173 0.368393473678457 398 745334 SGTC_2617 dihydrotanshinone i 20.83 µM 0.335714352754685 0.356509372725765 no 1174 0.368543140721732 370 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_2813 7971799 71.43 µM 0.334198734481207 0.357173415337159 no 1175 0.369114799444477 397 2234054 SGTC_1346 1488-2224 62.4 µM 0.332593339205001 0.357877264291639 no 1176 0.369720635973691 402 3722427 SGTC_1070 indatraline 8.81 µM 0.332143418406603 0.358074608642281 no 1177 0.369890483079265 426 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_2071 5230951 39.92 µM 0.331740028866684 0.358251575692042 no 1178 0.370042786009896 423 1799272 SGTC_2088 5278280 127.392 µM 0.330940705556637 0.35860232887289 no 1179 0.370344637074119 379 791502 SGTC_2022 5136654 200 µM 0.330315841956413 0.358876610029825 no 1180 0.370580661974814 420 1713771 SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.330095173349186 0.358973488951028 no 1181 0.370664025068332 370 3256 An antibiotic and ribosome inhibitor. SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.329923655089613 0.359048795932184 no 1182 0.37072882458145 419 551469 SGTC_3262 9137218 49.47 µM 0.329667225781481 0.359161394260356 no 1183 0.370825710285296 383 17650664 SGTC_2489 cantharidin 73.42 µM 0.329249229555578 0.359344962982669 no 1184 0.370983657754123 395 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1793 st048256 72.231 µM 0.328944115266071 0.359478978572573 no 1185 0.371098964459275 419 672022 SGTC_3238 9133470 49.47 µM 0.32856463197293 0.359645683436595 no 1186 0.371242392337039 402 3534688 SGTC_1137 ixabepilone 100 µM 0.328486392098958 0.359680057092883 no 1187 0.371271965768589 378 154225 A novel microtubule stabilizer. SGTC_297 0986-0032 24 µM 0.327760830161638 0.35999887719906 no 1188 0.371546252859725 408 2847425 SGTC_959 1222-0044 107 µM 0.327489073814331 0.360118315094826 no 1189 0.37164900280208 408 6083612 SGTC_2449 5812982 45.77 µM 0.327045287080448 0.360313390321565 no 1190 0.371816816374239 404 776185 SGTC_2955 9076254 12.21 µM 0.326156281254227 0.360704279760371 no 1191 0.372153058391599 396 16459619 SGTC_3127 9126946 49.47 µM 0.325061790254765 0.361185719458385 no 1192 0.372567153423689 421 27243249 SGTC_1333 1482-0047 286 µM 0.324853022112528 0.361277576436744 no 1193 0.372646156522419 428 3811116 SGTC_844 0330-0132 15.3 µM 0.323442611368025 0.361898359689035 no 1194 0.373180031527233 425 2828079 SGTC_268 camptothecin 39.6153 µM 0.321206959718319 0.362883111749805 no 1195 0.374026779143809 416 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1820 st053765 18.6 µM 0.319466589447159 0.363650332538177 no 1196 0.374686361405668 399 3690829 SGTC_3253 9135987 49.47 µM 0.318915751383135 0.363893276842654 no 1197 0.374895199821941 399 4182430 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.317804206252647 0.364383684664024 no 1198 0.375316729935332 425 91467 include heat shock SGTC_733 4069-0007 56.1 µM 0.314988180221066 0.365627092830783 no 1199 0.376385314115669 399 5717425 YNL287W SEC21 SGTC_2507 purpurin 79.67 µM 0.312719315532575 0.366629932273339 no 1200 0.37724695970258 384 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_74 000s-0487 160.283 µM 0.312536655906107 0.366710707648735 no 1201 0.377316354908983 335 677548 SGTC_2127 5253358 187.912 µM 0.312280406001987 0.366824035918708 no 1202 0.37741371487265 406 20612 SGTC_1693 xanthone 101.9 µM 0.312226001749947 0.366848098064956 no 1203 0.377434386306674 429 7020 An insecticide. SGTC_2472 5377652 49.4 µM 0.312042709938883 0.366929169004389 no 1204 0.377504032428395 416 1610903 SGTC_2340 7987427 183.45 µM 0.312020976317044 0.366938782294175 no 1205 0.377512290903729 386 2239331 SGTC_2474 5321570 43.32 µM 0.310879131052346 0.367443964405979 no 1206 0.377946254970752 442 2841384 SGTC_2736 butenafine 14.65 µM 0.308522934511899 0.368487131717342 no 1207 0.37884222579959 407 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2525 harmine 47.85 µM 0.308234165663684 0.368615046262279 no 1208 0.378952078384902 443 5280953 A monoamine oxidase inhibitor SGTC_3125 9127534 49.47 µM 0.30715005282497 0.369095400328993 no 1209 0.379364580559186 408 1639235 SGTC_3111 9122088 49.47 µM 0.30596654315717 0.369620029112604 no 1210 0.379815059809443 416 16876704 SGTC_1680 diphenhydramine 100 µM 0.305738747025683 0.369721034981782 no 1211 0.37990178458574 429 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_1176 0848-0131 83.3 µM 0.304597988785529 0.37022698762126 no 1212 0.380336175995935 434 6769040 SGTC_1975 st070967 30.8 µM 0.303383398573448 0.370765933347108 no 1213 0.380798847942845 449 261391 SGTC_2212 7123476 200 µM 0.302816030274186 0.371017776620743 no 1214 0.381015033129675 415 1085715 SGTC_1700 st030840 7.9285 µM 0.302291417340524 0.371250690824387 no 1215 0.381214960229644 422 5499307 SGTC_1573 oleylamine 1.06 µM 0.302110729934083 0.37133092215529 no 1216 0.381283826548884 436 5356789 An amine of the fatty acid oleic acid. SGTC_2641 levomentholum 100 µM 0.302040036019536 0.371362314170731 no 1217 0.381310771506893 426 16666 SGTC_1836 st055642 81 µM 0.301881897990175 0.37143253931654 no 1218 0.381371047838033 440 8571 SGTC_2837 9008476 45.46 µM 0.301521783819165 0.371592472984597 no 1219 0.381508320692603 424 2992805 SGTC_1729 st035615 45.989 µM 0.300887989186255 0.371874007264944 no 1220 0.381749954705705 391 17385451 SGTC_2991 9074669 71.4286 µM 0.300545784533539 0.372026044529801 no 1221 0.381880439290705 437 17333109 SGTC_252 miconazole 1.30953 nM 0.300148869837363 0.372202413780424 no 1222 0.382031801937039 421 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_1298 1079-1278 263 µM 0.29966371894532 0.372418027242552 no 1223 0.382216837775056 417 2840950 SGTC_102 gallobenzophenone 83.616 µM 0.299536793519873 0.372474442750382 no 1224 0.38226525138746 420 70837 SGTC_2840 9008771 71.43 µM 0.299198997799172 0.372624598708995 no 1225 0.382394106965889 386 2992978 SGTC_651 3253-0966 34.4 µM 0.298346276719235 0.373003733847032 no 1226 0.382719443911715 405 781462 SGTC_1814 st052110 31.539 µM 0.298026109726384 0.373146117641867 no 1227 0.382841617962318 421 674163 SGTC_604 1000-0114 314 µM 0.297849512715312 0.373224660799934 no 1228 0.382909011447829 422 1572745 SGTC_1845 st056753 3.01 µM 0.297836371429112 0.37323050571946 no 1229 0.382914026606952 386 5375839 SGTC_2056 5235370 200 µM 0.29741358959901 0.373418564194633 no 1230 0.383075384917483 396 5511916 SGTC_112 phenothiazine 287.218 µM 0.29669864307605 0.373736649647494 no 1231 0.383348296542826 449 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_50 0929-0078 56.389 µM 0.29610373209214 0.374001395905937 no 1232 0.383575431964038 426 1377751 SGTC_1173 0443-0020 122 µM 0.29604393324971 0.374028010773514 no 1233 0.383598265216456 417 5331295 SGTC_2683 piperine 63.03 µM 0.296020814313657 0.374038300555431 no 1234 0.38360709292884 432 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.295331898541273 0.374344964518146 no 1235 0.383870175571178 429 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_2698 st077697 67.5 µM 0.295184433606535 0.374410617396653 no 1236 0.383926496330305 404 3154499 SGTC_551 k048-0028 34.9 µM 0.293230601639121 0.375280826209968 no 1237 0.384672947441797 414 6836383 SGTC_976 1348-1067 47.6 µM 0.292024502198188 0.375818322975093 no 1238 0.385133945024026 400 5310671 YGL099W LSG1 SGTC_2208 7283366 200 µM 0.291505319599998 0.376049770351962 no 1239 0.38533243800182 420 898663 SGTC_3116 9124943 49.47 µM 0.291438181796618 0.376079703095967 no 1240 0.385358108203459 374 41905195 YPL160W CDC60 SGTC_2156 5649887 115 µM 0.290131304409252 0.376662510101654 no 1241 0.385857893907781 424 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_2187 6125751 200 µM 0.288766774873841 0.377271327411633 no 1242 0.386379929624275 412 874498 SGTC_1647 st011722 22.4 µM 0.28859425031615 0.377348325109057 no 1243 0.386445947981047 397 2854783 SGTC_1908 st060353 56.5 µM 0.288444978086438 0.377414949228775 no 1244 0.386503071239721 416 4227716 SGTC_723 4182-0001 115 µM 0.28775219506704 0.37772420422822 no 1245 0.386768216518482 425 744821 YLR208W SEC13 SGTC_1375 2910-0797 186 µM 0.287695637347305 0.377749454785509 no 1246 0.386789864898931 445 742508 SGTC_1939 st074455 53.6 µM 0.287404849717513 0.377879287036333 no 1247 0.386901174119429 450 1644229 SGTC_1570 verbenone 133 µM 0.285773290396398 0.378608008909788 no 1248 0.387525883276465 449 29025 A natural terpanoid with antifungal properties. SGTC_3105 9121040 49.47 µM 0.28575270627696 0.378617205392774 no 1249 0.387533766611945 411 41448907 SGTC_2845 9003024 42.97 µM 0.284612225684146 0.379126851605888 no 1250 0.387970621869906 391 2990173 SGTC_2873 9040596 71.43 µM 0.284214583776145 0.379304595183915 no 1251 0.388122969940339 450 6463863 SGTC_2295 7971645 200 µM 0.283658536113656 0.379553187976613 no 1252 0.388336036687674 436 2978226 YKL099C UTP11 SGTC_3345 9148410 3.559 µM 0.281823184795369 0.380374073289571 no 1253 0.389039546157053 435 4903596 SGTC_2696 st077691 74.316 µM 0.28179874513012 0.380385007899984 no 1254 0.389048916598371 449 757133 SGTC_3053 9095903 49.47 µM 0.281038677998901 0.38072511906273 no 1255 0.389340367033932 445 17174018 SGTC_957 1187-1561 14.1 µM 0.280968478000338 0.380756536473276 no 1256 0.389367288615447 437 1538454 SGTC_1912 st060209 90.8 µM 0.28096257355775 0.380759178992043 no 1257 0.389369552983471 456 688787 SGTC_997 3996-0078 137 µM 0.279676716382982 0.381334793523212 no 1258 0.38986277168467 411 735687 SGTC_2307 7538926 6.34 µM 0.279072030132201 0.381605572450851 no 1259 0.390094773724106 412 96582 SGTC_247 mechlorethamine 29.705 µM 0.278587283690126 0.381822684104045 no 1260 0.390280786325968 419 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_1776 st049249 45.9 µM 0.278544544412259 0.381841828257495 no 1261 0.390297187949672 394 1822314 SGTC_562 3772-2733 112 µM 0.278281800765979 0.381959525050789 no 1262 0.390398022730564 451 2876874 YIL048W NEO1 SGTC_1397 3532-0190 20.1 µM 0.278241173869034 0.381977724963648 no 1263 0.390413615028537 394 5322280 SGTC_607 4491-0986 66.8 µM 0.2770056922051 0.382531316651831 no 1264 0.390887867683541 411 698981 YDR232W HEM1 SGTC_2046 4110841 106 µM 0.27668776910937 0.382673809769707 no 1265 0.391009932101687 447 44119630 YMR134W ERG29 SGTC_674 0498-0004 451 µM 0.276008637653613 0.38297824964242 no 1266 0.391270715975633 410 4231473 SGTC_199 4063-0024 41.6 µM 0.275439419149806 0.383233473633658 no 1267 0.391489331361852 438 306215 SGTC_2856 9022925 19.48 µM 0.274831738937691 0.383505998878548 no 1268 0.39172275627069 407 4944862 SGTC_1615 st002656 86.5 µM 0.273776838608115 0.383979224939518 no 1269 0.39212806195951 393 1584458 SGTC_251 melphalan 456.522 µM 0.273540311506914 0.384085354272129 no 1270 0.392218954665059 437 460612 A DNA alkylator. SGTC_722 3534-0461 190 µM 0.272439726360489 0.384579299275946 no 1271 0.392641965127868 397 658262 SGTC_1696 st025591 34.7925 µM 0.272334636006997 0.384626473870697 no 1272 0.392682363301132 405 2787147 SGTC_2382 9035899 200 µM 0.272274024915167 0.384653682698532 no 1273 0.3927056635619 453 6462679 SGTC_3159 9100096 49.47 µM 0.270053667201544 0.385650810520146 no 1274 0.393559483182965 400 25236875 SGTC_3144 9087057 49.47 µM 0.269896708668019 0.385721326828317 no 1275 0.393619859674584 460 17249618 SGTC_1537 2',6'-dihydroxyflavanone 78 µM 0.268849955064674 0.386191695283476 no 1276 0.394022574739044 427 5106787 A p450 inhibitor. SGTC_3002 9075603 71.4286 µM 0.267936205556979 0.386602433924564 no 1277 0.394374212122515 432 20105405 SGTC_487 nimodipine 119 µM 0.267594246103424 0.386756180481857 no 1278 0.394505830219875 444 4497 L-type voltage-gated calcium channels inhibitor SGTC_2325 6158266 200 µM 0.265749116522043 0.387586065429937 no 1279 0.395216216749655 412 3623240 SGTC_918 glabranin 770.725 nM 0.265501564242507 0.387697446333823 no 1280 0.395311552497021 426 124049 Also referred to as licorice root. SGTC_691 1548-0686 185 µM 0.264763163655458 0.388029728898486 no 1281 0.395595957798501 452 46495133 SGTC_885 0865-0106 16.8 µM 0.263681727378979 0.388516526513793 no 1282 0.396012588404942 409 2793380 SGTC_1038 k292-0204 154 µM 0.262396873217386 0.38909511825448 no 1283 0.396507741532823 401 4454212 SGTC_1050 3232-1156 69.3 µM 0.262344281131593 0.389118806617437 no 1284 0.396528012870577 439 700529 SGTC_1811 st050069 61.5 µM 0.261891602785186 0.389322717615882 no 1285 0.396702506873228 456 3877702 SGTC_1275 0867-0008 21.1 µM 0.261633124924543 0.389439163806178 no 1286 0.396802151661149 433 3422836 SGTC_2275 7947463 200 µM 0.261255540671397 0.389609286149953 no 1287 0.396947724798513 437 1225414 SGTC_2395 5646831 180.19 µM 0.260062295620577 0.390147047182688 no 1288 0.397407860608 432 6808628 SGTC_1064 honokiol 6.76 µM 0.25991065808638 0.390215400914429 no 1289 0.397466344888659 421 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_2965 9082772 38.63 µM 0.25788185817137 0.391130249828525 no 1290 0.398249043254456 392 16459634 SGTC_3074 9116018 49.47 µM 0.256682212048259 0.391671491439043 no 1291 0.398712052157474 435 17027303 SGTC_3320 9137005 35.139 µM 0.255658293583267 0.392133616366592 no 1292 0.399107350985356 447 4908713 SGTC_1690 st023502 41.2 µM 0.255654664874095 0.392135254382224 no 1293 0.399108752086325 458 24207482 SGTC_652 0437-0092 114 µM 0.25496786855598 0.39244531171369 no 1294 0.399373958195738 417 3091274 SGTC_1637 st007924 17.4 µM 0.254777989689548 0.392531045451565 no 1295 0.399447288040428 418 683336 SGTC_3350 9150499 3.57 µM 0.253689054772171 0.393022819837992 no 1296 0.399867895263407 443 4910996 YPR165W RHO1 SGTC_373 0844-0104 25.9 µM 0.251892673134904 0.393834457468923 no 1297 0.400562011510628 426 5375804 SGTC_974 1326-0144 138 µM 0.250283566240457 0.394561872878554 no 1298 0.401184032180756 436 5411856 SGTC_1924 st058459 75.1 µM 0.249341253487106 0.394988027203247 no 1299 0.401548411547576 449 688683 SGTC_1694 st024011 44.9 µM 0.248913784287565 0.395181388607238 no 1300 0.401713736250601 442 2787533 SGTC_2825 7998094 58.44 µM 0.248426123875546 0.395402008421731 no 1301 0.401902361524859 448 2987815 SGTC_379 3970-0972 5.9 µM 0.248172995027844 0.395516538299924 no 1302 0.402000279855187 414 2898042 YBL034C STU1 SGTC_5 0352-0601 109.883 µM 0.24750744246729 0.395817715139332 no 1303 0.402257766196748 421 762456 SGTC_386 1509-0011 3.07 µM 0.246301540759448 0.396363569949037 no 1304 0.402724408662859 437 3107280 SGTC_443 clozapine 122 µM 0.245847752616999 0.396569031113044 no 1305 0.402900044990214 458 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_3027 9089541 49.47 µM 0.24578970884444 0.396595313601972 no 1306 0.402922511943072 431 9943819 SGTC_2584 androsterone 48.74 µM 0.244594642308876 0.397136549515393 no 1307 0.403385156447655 422 2754130 A steroid. SGTC_3244 9134489 49.47 µM 0.244540797390415 0.397160940113975 no 1308 0.403406004547642 439 16584271 SGTC_862 0452-0056 10.2 µM 0.244452396729384 0.397200984598414 no 1309 0.403440232807717 424 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_508 roscovitine 141 µM 0.243983717112131 0.397413309177405 no 1310 0.403621715382915 463 160355 A CDKinase inhibitor. SGTC_931 2812-0076 566 µM 0.240944762249653 0.398790773139593 no 1311 0.404798964325487 424 3450959 SGTC_331 k048-0133 24.5 µM 0.240456736682952 0.399012098001509 no 1312 0.404988099284165 415 6813582 SGTC_322 k048-0136 19.3 µM 0.240223618754501 0.399117830962642 no 1313 0.405078452284135 427 6823282 SGTC_1347 1493-0251 600 nM 0.240126610344994 0.399161832275567 no 1314 0.405116052774589 431 3986378 SGTC_431 k089-0097 107 µM 0.239893003811033 0.399267797358274 no 1315 0.405206602335229 427 5499420 SGTC_2539 epi(13)torulosol 80 µM 0.239865844021209 0.39928011765546 no 1316 0.405217130225606 420 6708597 SGTC_1226 3909-7979 35.4 µM 0.239183633826779 0.399589616561637 no 1317 0.405481596361266 453 6615510 SGTC_2695 st077686 51.995 µM 0.238871249821569 0.399731357167154 no 1318 0.405602709800524 410 2876092 SGTC_3260 9137109 49.47 µM 0.238233192962129 0.400020909079201 no 1319 0.405850116928326 445 17478346 SGTC_35 0133-0054 64.071 µM 0.238191839067245 0.400039677486172 no 1320 0.405866153237514 420 99677 SGTC_3060 1327-0027 12.5 µM 0.238149151859104 0.40005905125767 no 1321 0.405882706747689 440 16000455 YPR107C YTH1 SGTC_89 0302-0250 142.109 µM 0.238023911800647 0.40011589341175 no 1322 0.405931274084898 464 4203518 YLR208W SEC13 SGTC_181 1447-1644 8.07 µM 0.237737276825 0.400245995128646 no 1323 0.406042434842402 444 534600 SGTC_894 0960-0238 55.9 µM 0.235844382451959 0.401105444660274 no 1324 0.406776713594899 456 6741907 YDL195W SEC31 SGTC_1134 3477-0009 42.5 µM 0.235691812185816 0.401174738551245 no 1325 0.40683591193008 458 3973534 SGTC_135 0933-0004 26.348 µM 0.235587570785955 0.4012220843751 no 1326 0.406876359549777 467 21230617 YGL099W LSG1 SGTC_208 k072-0098 12.366 µM 0.234640795748985 0.401652170298896 no 1327 0.407243771465027 431 5948901 SGTC_2430 5571206 200 µM 0.233916750346909 0.401981158575127 no 1328 0.407524804514126 453 1731771 SGTC_3190 9110366 49.47 µM 0.233090205910837 0.402356804768901 no 1329 0.4078456800094 457 17123768 SGTC_2687 chenodiol 100 µM 0.231724704856349 0.40297759226671 no 1330 0.408375920942387 423 5702181 A cholesterol synthesis inhibitor. SGTC_742 0kpi-0133 140 µM 0.230537624091047 0.403517464736771 no 1331 0.408837015454517 459 2728852 SGTC_2533 agelasine 13.65 µM 0.230506282987347 0.403531720853831 no 1332 0.408849190905798 462 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_2499 avocadenofuran 51.48 µM 0.229940138340279 0.403789264927701 no 1333 0.409069142984057 434 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_1438 4092-1045 4 µM 0.229706452958838 0.403895582589681 no 1334 0.409159940123207 435 1351342 SGTC_1850 st056238 17 µM 0.228520374712692 0.404435310882698 no 1335 0.409620859198196 469 5393177 SGTC_290 2043-6722 48.1 µM 0.228238514318658 0.404563599050411 no 1336 0.409730410699482 447 773758 YLR208W SEC13 SGTC_1158 4092-0494 91.8 µM 0.228182461058162 0.404589112798061 no 1337 0.409752197924122 449 1148199 SGTC_2379 9035213 200 µM 0.227977150276859 0.4046825675153 no 1338 0.409832002121658 469 646551 SGTC_602 3130-1533 38.1 µM 0.227539779310794 0.404881671043818 no 1339 0.410002020447053 460 720941 SGTC_253 dyclonine 31.25 µM 0.226608879439234 0.405305524698118 no 1340 0.410363943554598 416 3180 An oral anasthetic. SGTC_1053 3366-3204 134 µM 0.225357598144311 0.405875428084034 no 1341 0.410850547497864 420 3632071 YPR165W RHO1 SGTC_3356 9151811 4.48 µM 0.224795634055603 0.406131442918965 no 1342 0.411069131340808 469 1859254 YPR165W RHO1 SGTC_952 1185-0122 232 µM 0.22445292202126 0.406287592474265 no 1343 0.411202447570584 458 678600 SGTC_696 1560-0013 611 µM 0.223513046746398 0.40671590336702 no 1344 0.411568115060632 411 1650269 SGTC_3016 9080866 49.47 µM 0.222625861597464 0.407120305238633 no 1345 0.411913353442921 464 17066299 SGTC_270 tamoxifen 5.46 µM 0.221583108695861 0.407595745483198 no 1346 0.412319216472974 455 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_2302 7771753 200 µM 0.221568736818147 0.407602299252984 no 1347 0.412324810989256 442 2203047 SGTC_583 1488-1091 88.9 µM 0.221252410056493 0.407746555061608 no 1348 0.412447951476586 460 4303273 SGTC_2110 5483698 200 µM 0.218443187217632 0.409028203281087 no 1349 0.413541909684261 416 2848765 YHR062C RPP1 SGTC_1091 telmisartan 47.6 µM 0.217816707069277 0.409314154736572 no 1350 0.413785963364372 448 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_1487 3970-0795 2.82 µM 0.216321756084669 0.409996706918212 no 1351 0.414368475810227 422 3765103 SGTC_2729 fluphenazine 10.66 µM 0.215973716679337 0.410155651053855 no 1352 0.41450411756404 453 3372 An atypical antipsychotic. SGTC_1254 0550-0035 264 µM 0.215772176313673 0.410247698127157 no 1353 0.414582668759829 461 15121435 SGTC_291 SEC14.278 35.5 µM 0.215265429510244 0.410479160251566 no 1354 0.414780190520072 443 1068044 SGTC_1766 st045414 44.774 µM 0.214429773978735 0.410860923098858 no 1355 0.415105962659306 441 253960 SGTC_1773 st048542 73.5835 µM 0.21442416352397 0.410863486478067 no 1356 0.415108150037782 450 3237138 SGTC_1310 1188-0297 994 nM 0.21422720342006 0.410953478642292 no 1357 0.415184941610658 447 1588352 SGTC_2658 polymyxin b sulfate 77.05 µM 0.214123736351416 0.411000755198052 no 1358 0.415225283052945 435 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_54 0159-0055 9 µM 0.213752780118032 0.411170264513682 no 1359 0.415369924913294 453 3319099 SGTC_2941 9056145 11.23 µM 0.213335796387625 0.411360826000977 no 1360 0.415532527333852 476 2119517 SGTC_1044 1222-0021 1.78 µM 0.212501385353037 0.411742214443914 no 1361 0.415857948553658 430 4306703 SGTC_2066 5222451 176 µM 0.211921839547163 0.412007159455917 no 1362 0.416084006026746 466 2281147 SGTC_2593 nobiletin 86.24 µM 0.211123875267984 0.412372022219512 no 1363 0.416395305166911 414 72344 An anti-infammatory. SGTC_1843 st055809 45.5 µM 0.21074009186609 0.41254753109494 no 1364 0.416545044147059 433 16413835 SGTC_2231 micatex 6.853 µM 0.210612905215093 0.412605698976184 no 1365 0.416594670642483 451 20737 An antifungal of unknown mechanism. SGTC_2844 9010103 25.97 µM 0.210522310703856 0.412647132881455 no 1366 0.416630020195104 458 2480525 SGTC_529 4076-0302 30.3 µM 0.210150872869992 0.412817022219274 no 1367 0.416774960538419 446 5816522 SGTC_2557 derrustone 83.84 µM 0.209670265356046 0.413036868141507 no 1368 0.416962517236933 460 629853 An antioxidant. SGTC_1274 0865-0114 173 µM 0.20927761931381 0.413216497797367 no 1369 0.417115761071767 415 870624 SGTC_1132 3456-3614 2.5 µM 0.207028810963247 0.414245642691349 no 1370 0.41799367900369 426 3125502 SGTC_2959 9079155 11 µM 0.20547287393068 0.414958047117479 no 1371 0.418601344707579 466 16189457 SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.204381090479974 0.415458100420592 no 1372 0.419027852960302 471 140250 A respiratory chain inhibitor. SGTC_2908 7930301 100 µM 0.203032455578631 0.41607598456261 no 1373 0.419554832300503 418 2223178 SGTC_2607 solasodine 47.35 µM 0.202731466921967 0.416213912467043 no 1374 0.419672463405247 434 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.20159435163584 0.416735087985468 no 1375 0.420116930656957 439 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_2620 irigenin 100 µM 0.201361555241314 0.416841803939928 no 1376 0.420207936982001 487 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_1234 0326-0494 15.5 µM 0.201076108375798 0.416972663705316 no 1377 0.420319531603675 463 1547813 SGTC_1902 st060212 70.5 µM 0.200672774720777 0.417157582965312 no 1378 0.420477224640298 437 688944 SGTC_258 haloperidol 50.781 µM 0.200173964620984 0.417386301336556 no 1379 0.42067226415062 482 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_828 2074-0507 139 µM 0.198418470394665 0.418191466323058 no 1380 0.421358833719811 466 X828 SGTC_111 0083-0039 52.457 µM 0.198074661497401 0.418349196021235 no 1381 0.421493324625815 471 759313 SGTC_3031 9088762 49.47 µM 0.197893072137864 0.418432509331475 no 1382 0.421564362312267 432 205253 SGTC_2400 5203494 178.7 µM 0.196889249400537 0.418893129751891 no 1383 0.421957103374302 447 6777674 SGTC_787 4152-0075 138 µM 0.196849595613534 0.418911327825636 no 1384 0.421972619333754 427 9566539 SGTC_2576 guaiol 23.12 µM 0.196706029558211 0.418977215182077 no 1385 0.422028795689793 426 227829 SGTC_1365 1672-3266 55.4 µM 0.194410983256297 0.420030797479079 no 1386 0.422927045296746 473 6415873 SGTC_1020 4335-0961 93.3 µM 0.193987036447179 0.420225480851161 no 1387 0.423093016256041 457 669075 SGTC_769 0302-0231 76 µM 0.192855822537478 0.42074504835311 no 1388 0.423535941976578 464 571869 YER009W NTF2 SGTC_2933 9026794 32.47 µM 0.192497607394544 0.420909605700645 no 1389 0.423676220944394 470 17586027 SGTC_1048 3161-0300 24.5 µM 0.190794708699928 0.421692074086932 no 1390 0.424343217190535 435 2165101 SGTC_2167 5876490 200 µM 0.190712340133747 0.421729929653488 no 1391 0.424375485057322 464 686534 SGTC_665 3914-0008 307 µM 0.190542520950379 0.421807978716414 no 1392 0.424442013282791 444 1069549 SGTC_1312 1218-2183 165 µM 0.190483037311799 0.421835318181463 no 1393 0.424465317053956 470 6744073 SGTC_1496 4469-0713 57.4 µM 0.188918820687297 0.422554387599286 no 1394 0.42507822120638 466 746691 SGTC_2378 9074213 121.43 µM 0.188517728086827 0.422738811301814 no 1395 0.425235409827289 472 657714 SGTC_1962 st076595 64.5 µM 0.18848560174411 0.422753583833412 no 1396 0.42524800068997 446 279619 SGTC_1168 k815-0004 80.5 µM 0.188307948680879 0.422835275313336 no 1397 0.425317627337332 458 642433 SGTC_2044 5102272 200 µM 0.188218806154369 0.422876267610024 no 1398 0.425352565385024 444 592666 SGTC_1297 1068-0111 14.1 µM 0.188006884690383 0.422973723298614 no 1399 0.425435627109253 466 767057 SGTC_202 3594-0513 34.79 µM 0.187223608441046 0.423333967064087 no 1400 0.425742657625587 446 708429 SGTC_1495 4469-0029 237 µM 0.187125357288569 0.423379159183666 no 1401 0.425781173531771 449 793680 SGTC_1075 aripiprazole 15.2 µM 0.186230260751693 0.423790918870394 no 1402 0.426132097191891 436 60795 An atypical antipschotic. YIL048W NEO1 SGTC_490 phenamil 164 µM 0.186173159925613 0.423817189053687 no 1403 0.426154485626469 462 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_2839 9003951 25.97 µM 0.185503079607317 0.424125495900589 no 1404 0.426417232504715 483 2990634 SGTC_2158 5657123 3.6195 µM 0.184115771458123 0.424763949766952 no 1405 0.42696131707381 474 2858827 SGTC_986 1493-0483 84 µM 0.183830543585628 0.424895239169216 no 1406 0.427073197067908 475 40079 SGTC_2874 9043904 71.43 µM 0.183037110896403 0.425260497266978 no 1407 0.427384450092605 445 4463428 SGTC_31 0508-1974 57.237 µM 0.182715792142112 0.425408435176773 no 1408 0.42751051201059 462 6810525 SGTC_1439 4092-1168 46 µM 0.180946056911197 0.426223424125135 no 1409 0.428204958649472 480 2886240 SGTC_3351 9150312 21.596 µM 0.179890373591146 0.426709732036043 no 1410 0.428619316340441 482 4904905 SGTC_514 4466-0038 2.65 nM 0.179443074289189 0.426915817243289 no 1411 0.428794905920918 458 5722064 SGTC_1813 st051246 8.6015 µM 0.178690047319266 0.427262806079565 no 1412 0.429090542247081 469 5291959 SGTC_193 1273-0060 1.558 µM 0.178576475124838 0.427315144133891 no 1413 0.429135133836101 477 2847393 YHR072W ERG7 SGTC_2161 5662504 8.5105 µM 0.177627732559523 0.427752407910508 no 1414 0.42950767172327 423 2859334 SGTC_110 0850-0284 111.64 µM 0.177571153678172 0.427778487230257 no 1415 0.429529890250042 458 3906265 SGTC_1164 k060-0068 93.7 µM 0.177166023689318 0.427965235986271 no 1416 0.429688991314814 475 5963676 SGTC_1847 st056231 15 µM 0.175426338090908 0.428767344528817 no 1417 0.430372323332568 433 5393180 SGTC_2971 9092186 9.93 µM 0.174481888156961 0.429202921022737 no 1418 0.430743381797443 400 25236400 SGTC_978 1416-0512 87.4 µM 0.173648523236661 0.429587337180844 no 1419 0.431070847628391 459 6814003 SGTC_2296 7971656 126.45 µM 0.172439776085849 0.430145028942122 no 1420 0.431545901854859 455 666570 SGTC_1921 5740136 50 µM 0.171403707843342 0.430623161094603 no 1421 0.431953169743718 489 1774243 SGTC_2456 5770359 74.46 µM 0.170889842646216 0.430860341046865 no 1422 0.432155191786763 487 3118787 SGTC_1304 1165-0502 251 µM 0.169931976721221 0.431302520769681 no 1423 0.432531816526251 449 767425 SGTC_2041 5107442 45.335 µM 0.169132249078868 0.431671765089023 no 1424 0.432846309613229 461 793005 SGTC_1390 3413-2614 145 µM 0.168952736282342 0.431754656623911 no 1425 0.432916908916696 485 3421432 SGTC_1105 epirubicin 18.1 µM 0.165189378054878 0.433493105115296 no 1426 0.434397462748512 463 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1559 coumarin 343 70.1 µM 0.16469801599589 0.433720181015063 no 1427 0.434590839331021 465 108770 A hepatotoxic, DNA x-linker. SGTC_718 1130-0073 349 µM 0.164590341218293 0.433769944287944 no 1428 0.434633217060621 469 6740020 SGTC_2124 5246320 200 µM 0.163550018891276 0.43425079648626 no 1429 0.435042696947119 469 579342 SGTC_3065 9113888 49.47 µM 0.162828803388551 0.434584209993231 no 1430 0.435326614542963 458 16648368 SGTC_2857 9024691 58.44 µM 0.162561608705655 0.434707744282662 no 1431 0.435431808319587 481 16478292 SGTC_1434 4073-0095 163 µM 0.161050052740866 0.435406713927981 no 1432 0.43602698937269 478 24133745 SGTC_2145 5634607 200 µM 0.160971324177084 0.435443124928205 no 1433 0.436057993033257 458 308662 SGTC_9 0092-0002 10.449 µM 0.160860455283576 0.435494401366814 no 1434 0.436101654365652 466 759368 SGTC_2931 9014674 55.67 µM 0.160298299359561 0.435754413002304 no 1435 0.436323049234049 462 2996810 SGTC_3223 9129970 49.47 µM 0.159521841652887 0.436113590397247 no 1436 0.436628875750502 461 17248386 SGTC_1638 st008370 60.6 µM 0.159270489684336 0.43622987325651 no 1437 0.436727884885386 457 24207134 SGTC_3042 9091578 49.47 µM 0.15916985016886 0.436276433620592 no 1438 0.436767528540528 455 25236497 SGTC_1383 3049-0032 20.7 µM 0.157280593649155 0.437150651799103 no 1439 0.437511856963545 493 712864 SGTC_1429 4049-0205 9.46 µM 0.156989673792785 0.43728529691109 no 1440 0.437626493154842 451 22774478 SGTC_1671 st016596 74.5 µM 0.156278032954234 0.437614692984557 no 1441 0.437906935373065 475 2829167 SGTC_825 1988-2224 89.6 µM 0.15619707870909 0.437652166891877 no 1442 0.437938839663588 468 1180859 SGTC_928 2764-0428 58.7 µM 0.155931499287993 0.43777510814507 no 1443 0.438043508074992 494 662578 SGTC_415 dibenzyl ketone 100 µM 0.152332543964634 0.439441713520635 no 1444 0.439462329032753 491 7593 SGTC_2828 7998861 71.43 µM 0.151586679744284 0.439787243882816 no 1445 0.439756470006724 486 2988188 SGTC_333 3486-0131 40.1 µM 0.151217696677424 0.43995819659889 no 1446 0.439901995444831 501 6744690 SGTC_3287 9117173 37.0625 µM 0.150799974286005 0.440151744130969 no 1447 0.44006675327536 481 2789709 SGTC_2709 st078560 56 µM 0.150591204703642 0.44024848081189 no 1448 0.440149099948084 479 17250903 SGTC_2310 7668677 200 µM 0.149968224140264 0.440537169867592 no 1449 0.440394842579516 488 2197143 SGTC_1955 wogonin 32.4 µM 0.149541591257197 0.440734889696137 no 1450 0.440563146614859 432 5281703 A flavanone. SGTC_2726 cimetidine 79.27 µM 0.147817085576028 0.441534249064545 no 1451 0.441243562562956 493 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_3271 9137798 49.47 µM 0.14772704294524 0.441575993057446 no 1452 0.441279094303917 480 6498326 SGTC_801 0866-0028 10.1 µM 0.147421697561284 0.44171755678398 no 1453 0.441399590225666 498 6849771 SGTC_2387 9077560 195.08 µM 0.14707096263614 0.441880173121459 no 1454 0.441538004539301 449 5303272 SGTC_1643 st009866 20.2 µM 0.145671997364134 0.442528892941748 no 1455 0.442090164193364 487 3156273 YOR207C RET1 SGTC_537 1334-0398 209 µM 0.145314938716397 0.442694490803515 no 1456 0.442231110263321 466 5846986 SGTC_2406 ethylparaben 405.7 µM 0.145042078187002 0.442821045729034 no 1457 0.442338824724443 430 8434 A possible steroid mimic. SGTC_1560 lithocholic acid 53.1 µM 0.143444223117718 0.443562260565149 no 1458 0.442969679537939 493 9903 A bile acid which acts as a detergent. SGTC_2346 9031566 143.75 µM 0.14330081384275 0.443628795120311 no 1459 0.443026306556526 480 4771086 SGTC_3069 9117009 49.47 µM 0.143214595898953 0.443668796593348 no 1460 0.443060351393902 492 41904981 SGTC_1765 st044815 90.4 µM 0.141656114322691 0.444391964580202 no 1461 0.443675820487044 488 645695 SGTC_1335 1486-0900 202 µM 0.141412072270275 0.444505222015687 no 1462 0.443772208907148 479 X1335 SGTC_2206 7254556 146.969 µM 0.140706106945454 0.444832878826897 no 1463 0.444051060226537 485 4398905 SGTC_662 k832-1615 104 µM 0.138911356357274 0.445666038339152 no 1464 0.444760098450558 501 5878478 SGTC_910 3454-3003 490 µM 0.137256989977752 0.4464342413341 no 1465 0.445413832814591 499 820824 SGTC_3277 9138724 49.47 µM 0.136990955687205 0.446557792872352 no 1466 0.445518972014358 493 15943418 SGTC_1791 st048313 56.1 µM 0.136981670442755 0.446562105215613 no 1467 0.445522641697656 501 1204976 SGTC_852 0418-0143 439 µM 0.136477157632534 0.446796425433542 no 1468 0.445722040573824 482 5369229 SGTC_3181 9108277 49.47 µM 0.136234744376001 0.446909020519024 no 1469 0.445817854585416 495 17097298 SGTC_2778 tioconazole 65.09 nM 0.13551849487827 0.447241726029727 no 1470 0.446100971173466 484 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_274 sirtinol 40.1 µM 0.134060503780658 0.447919092875696 no 1471 0.446677365535035 451 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_2244 6635614 200 µM 0.133509920849662 0.448174927350094 no 1472 0.446895059403846 466 836499 SGTC_2424 5537928 59.2 µM 0.133187026891855 0.448324973649021 no 1473 0.44702273523981 496 5382802 SGTC_774 k060-0086 136 µM 0.132002870625637 0.448875304921565 no 1474 0.44749101059445 493 5911235 SGTC_1172 0370-0043 85 µM 0.131819416693455 0.448960573135283 no 1475 0.447563564134714 476 376585 SGTC_1446 4239-0190 62 µM 0.131779186377848 0.448979272243837 no 1476 0.447579474913168 497 1340085 SGTC_1625 st003711 30.1 µM 0.131194338458588 0.449251123175786 no 1477 0.447810787252326 484 24207034 YER133W GLC7 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.129391738375493 0.450089162995666 no 1478 0.448523842274933 477 803109 SGTC_2473 5854593 8.94 µM 0.128472843218922 0.450516448882989 no 1479 0.44888739404066 469 2872951 SGTC_1795 st049545 62.3 µM 0.128344493684159 0.45057613594304 no 1480 0.448938177685745 483 5291882 SGTC_2381 9035592 200 µM 0.127600545512897 0.450922120052798 no 1481 0.449232549702735 473 4749657 SGTC_261 5-fluorouridine 15.376 µM 0.126928093618893 0.451234885856869 no 1482 0.449498655488503 474 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1153 4055-0057 267 µM 0.126709631756241 0.451336501732502 no 1483 0.449585111125089 477 882706 SGTC_2183 6420625 130.508 µM 0.126257022569039 0.4515470395972 no 1484 0.449764237484283 460 2897619 SGTC_3307 9126885 69.2785 µM 0.125629228794378 0.451839089717451 no 1485 0.450012712510763 467 24824909 SGTC_2524 avocatin b 10.57 µM 0.12549519512425 0.45190144566008 no 1486 0.450065764351867 501 6710748 SGTC_2350 9023895 38.85 µM 0.125243498568924 0.452018544636347 no 1487 0.450165390727392 502 2997209 SGTC_1751 st044839 27.194 µM 0.125216822223223 0.452030955749367 no 1488 0.450175949926297 493 5291326 SGTC_1673 st016611 27.3 µM 0.124367675815353 0.452426043737993 no 1489 0.450512082787949 494 5226799 SGTC_2122 5258151 111.688 µM 0.122606018962443 0.453245851332429 no 1490 0.451209543982863 462 2173356 SGTC_840 0245-0196 390 µM 0.122504225133275 0.45329322840415 no 1491 0.451249850012336 476 3827528 SGTC_1767 st044992 70.3 µM 0.122001733324314 0.453527108796449 no 1492 0.45144882276622 508 9600693 SGTC_2944 9067346 25.62 µM 0.12140774807496 0.453803594788303 no 1493 0.451684040101251 477 6473075 SGTC_2397 5161689 200 µM 0.120467922642123 0.454241106840114 no 1494 0.45205624429023 495 2259942 SGTC_820 1582-0060 59.9 µM 0.120391328761946 0.454276765645522 no 1495 0.452086580043703 475 3848840 SGTC_2048 5246248 200 µM 0.119591847527588 0.45464899155441 no 1496 0.452403239051652 507 677046 SGTC_788 1182-0090 188 µM 0.119024342644882 0.454913237105253 no 1497 0.452628035112736 431 5715185 SGTC_2804 7954240 19.48 µM 0.118793660805421 0.455020654489776 no 1498 0.452719415532712 479 828705 SGTC_857 0438-0306 1.35 µM 0.11828815398439 0.455256056076315 no 1499 0.45291967162621 473 4686136 SGTC_3100 9120536 49.47 µM 0.118138094655415 0.455325937892507 no 1500 0.452979119807885 491 16421196 SGTC_2254 7938975 95.19 µM 0.116662118735501 0.456013365208729 no 1501 0.453563905051766 483 2969277 SGTC_1240 0356-0016 42.1 µM 0.115842964908403 0.456394938361492 no 1502 0.453888499321551 508 4305613 SGTC_2194 5927483 104.545 µM 0.115618381143906 0.456499559616082 no 1503 0.453977497279384 442 760979 SGTC_2900 5328528 85.29 µM 0.11473555915441 0.456910847105137 no 1504 0.454327363953357 506 795359 SGTC_1359 1582-0056 520 nM 0.113622327737639 0.45742954306632 no 1505 0.454768593498942 488 3661189 SGTC_3352 9151559 45.5865 µM 0.11283797736548 0.45779504470738 no 1506 0.455079504509501 477 17159339 SGTC_1998 st075797 76.8 µM 0.112014160559114 0.458178975852932 no 1507 0.455406089365628 507 24208315 SGTC_3089 9117425 49.47 µM 0.111976334657847 0.458196605155531 no 1508 0.455421085374428 499 9401657 SGTC_2949 9072542 2.23 µM 0.111458667883113 0.458437879413104 no 1509 0.455626319786411 473 16457352 SGTC_2143 5623677 140.463 µM 0.109596238123184 0.459306047156688 no 1510 0.456364797114722 505 5375313 SGTC_2699 st077704 54.6 µM 0.109435260881541 0.45938109553424 no 1511 0.456428633773528 474 645852 SGTC_1367 1812-0510 76.9 µM 0.109120953146162 0.459527631507788 no 1512 0.456553277959411 487 1142582 YDR527W RBA50 SGTC_2932 9016711 44.54 µM 0.108728989587846 0.4597103797377 no 1513 0.456708723897752 488 7117328 SGTC_2057 5236571 38.335 µM 0.107883940512582 0.4601044024751 no 1514 0.457043878188472 494 54684039 YBR257W POP4 SGTC_2681 menadione 3.18 µM 0.1076590090834 0.46020928832507 no 1515 0.457133093235667 508 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_143 4032-1194 15.74 µM 0.106751025642264 0.460632710386733 no 1516 0.457493250620773 472 1806963 SGTC_136 0097-0015 404.482 µM 0.10567848586528 0.461132927865892 no 1517 0.457918725271274 481 4861337 SGTC_3148 9097893 49.47 µM 0.103366382392428 0.462211468597511 no 1518 0.45883609607841 501 17174100 SGTC_1594 piperine 70.1 µM 0.101898775063228 0.462896216858058 no 1519 0.459418511130428 503 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1147 3809-1045 12.3 µM 0.100660276780947 0.463474154297205 no 1520 0.459910072844466 479 325925 SGTC_1788 fluconazole 20 µM 0.100516881066401 0.463541074009146 no 1521 0.459966990778577 504 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_3115 9123671 49.47 µM 0.100442580049968 0.463575749109678 no 1522 0.459996483338047 512 3286988 SGTC_3179 9107801 49.47 µM 0.0997328011311459 0.463907005531947 no 1523 0.460278229410422 472 4818259 SGTC_2744 captopril 92.04 µM 0.0992198228649243 0.464146429959346 no 1524 0.460481868073899 504 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_1244 0416-0015 52.5 µM 0.0982617167825055 0.464593645404387 no 1525 0.460862238302484 498 96201 SGTC_1 0258-0098 57.368 µM 0.098034537358243 0.464699692589821 no 1526 0.460952434300461 471 6790032 YDR047W HEM12 SGTC_2502 avocadyne acetate 18.59 µM 0.097869557212379 0.464776706770706 no 1527 0.461017936865479 510 3952079 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 0.0969521879215676 0.465204966800057 no 1528 0.461382182004737 515 676296 Flavone; oxidizing agent. SGTC_2195 6536160 144.242 µM 0.0957321570629934 0.465774582182544 no 1529 0.461866650270174 478 3834386 SGTC_1349 flufenamic acid 69 µM 0.0936885356315592 0.466728877038532 no 1530 0.462678288729592 494 3371 A non-steroidal anti-inflammatory. SGTC_2993 9054257 71.4286 µM 0.0936618357397487 0.466741346168357 no 1531 0.462688893813074 509 6470217 YGL055W OLE1 SGTC_1519 esterone 74 µM 0.0928342401766597 0.467127858112131 no 1532 0.46301762436526 483 698 A steroid. SGTC_1684 st024538 14.6195 µM 0.0914985648024105 0.467751723791974 no 1533 0.463548223288005 505 6732859 SGTC_872 0588-0139 234 µM 0.0913292305955813 0.467830821903594 no 1534 0.463615496191479 499 2047100 SGTC_886 0866-0150 153 µM 0.0888294625436296 0.468998640726612 no 1535 0.464608721258076 510 271463 SGTC_182 3448-4371 550.524 µM 0.0883392716087997 0.46922767525514 no 1536 0.46480351335885 513 3491403 SGTC_1193 1488-0126 41.5 µM 0.0883302047059961 0.469231911728715 no 1537 0.464807116444785 500 1384710 SGTC_1311 1190-0148 100 µM 0.088146232071992 0.469317872947841 no 1538 0.46488022573824 505 1961333 SGTC_531 3788-1495 174 µM 0.0873081361237407 0.469709491344633 no 1539 0.465213293513635 474 2896655 SGTC_1964 st076914 61 µM 0.0864695568255883 0.470101364925719 no 1540 0.465546577770519 512 24208661 SGTC_518 1021-0119 62.6 µM 0.0855438085664341 0.470534006747071 no 1541 0.465914534443928 488 1097762 SGTC_1627 st003713 25.6 µM 0.0850403990271865 0.470769286224013 no 1542 0.466114636620107 503 16195070 YER133W GLC7 SGTC_794 k038-0031 316 µM 0.0850301088262033 0.470774095681581 no 1543 0.466118727000827 517 6624242 SGTC_380 3970-0968 6 µM 0.0842064281783594 0.471159083185683 no 1544 0.46644615369798 513 2891601 SGTC_1484 3473-2379 286 µM 0.0838747239586449 0.471314129036653 no 1545 0.466578018045041 522 671917 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.0837837748547014 0.471356641409535 no 1546 0.466614174223569 480 6312947 SGTC_2549 cedrol 20.94 µM 0.0835207855929483 0.471479572410939 no 1547 0.466718725309596 502 6708665 A sedative which affects the nervous system. SGTC_3215 9129942 49.47 µM 0.0811829300059331 0.47257249150956 no 1548 0.467648237292401 516 17682944 SGTC_2047 4141938 200 µM 0.0806692864418322 0.472812641598159 no 1549 0.467852481527421 520 3807862 SGTC_2779 methotrexate 400 µM 0.0804258308356893 0.472926470847485 no 1550 0.467949291704126 521 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_1622 st003707 19.4 µM 0.0803585028170528 0.472957950890396 no 1551 0.467976065040768 506 10140899 SGTC_1032 k061-1018 98.7 µM 0.0799420404897019 0.47315267671792 no 1552 0.468141676664908 493 4005393 SGTC_3245 9134821 49.47 µM 0.0786811634438189 0.473742265550453 no 1553 0.468643114209193 511 17014901 SGTC_3259 9138485 49.47 µM 0.0785307509343874 0.473812602630524 no 1554 0.468702935019573 463 17646153 SGTC_1116 jasmonic acid  1.58368 µM 0.0783734794639178 0.473886148024914 no 1555 0.468765484474458 516 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_2002 4023503 131 µM 0.0779939896914197 0.474063613782194 no 1556 0.468916416980825 513 4736863 YCR052W RSC6 SGTC_2582 agaric acid 100 µM 0.0769945714507154 0.474531009318763 no 1557 0.469313931752188 501 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_440 fluspirilene 35.1 µM 0.076846215915686 0.474600393400477 no 1558 0.469372942214119 508 3396 An atypical antipsychotic. SGTC_33 0986-0033 35.816 µM 0.0760239464119806 0.474984972769955 no 1559 0.469700023422154 514 2848082 SGTC_84 0443-0269 128.823 µM 0.0757197820944047 0.475127237797049 no 1560 0.469821018669512 523 6150058 SGTC_1036 k216-0215 33.5 µM 0.0757003116883543 0.475136344686293 no 1561 0.469828764007679 503 622330 SGTC_3090 9117696 49.47 µM 0.0756687379259 0.475151112703691 no 1562 0.469841324091903 518 7923821 SGTC_1471 k673-0312 37 µM 0.0748159348815973 0.475550007699506 no 1563 0.470180581574664 508 24099884 SGTC_633 0437-0093 97.7 µM 0.0746136615071695 0.475644623820449 no 1564 0.470261052056812 505 2831118 SGTC_1790 st045711 43.5 µM 0.0745844008871393 0.475658310987119 no 1565 0.470272692919396 509 585119 SGTC_1483 3453-0561 55.9 µM 0.0742210811038029 0.475828262556209 no 1566 0.470417235909068 510 4546991 SGTC_180 1486-1293 102.781 µM 0.0741146387076019 0.475878054382019 no 1567 0.470459583646265 504 4140536 SGTC_455 paf C-16 10 µM 0.0739752944207987 0.475943237685768 no 1568 0.470515021791094 502 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_510 ag-490 170 µM 0.0737575016133352 0.476045119396466 no 1569 0.470601671835516 516 5328779 SGTC_2282 7944268 200 µM 0.0733942671015668 0.476215041038779 no 1570 0.470746189741909 504 2970414 SGTC_3140 9094243 49.47 µM 0.0732805657955189 0.476268231568393 no 1571 0.470791428181797 518 19291112 SGTC_1432 4049-0298 68.4 µM 0.0730556297941538 0.476373459969024 no 1572 0.470880924778849 522 741646 SGTC_1665 st014639 11.4 µM 0.0727806068897963 0.476502122004529 no 1573 0.470990351741663 514 981133 YIL048W NEO1 SGTC_1525 8-methoxypsoralen 92.5 µM 0.0727171402512699 0.476531813505065 no 1574 0.471015604355221 523 4114 Related to psoralen; DNA damaging agent. SGTC_460 trequinsin 123 µM 0.0725973409781321 0.476587859370946 no 1575 0.471063271365359 515 5537 A vasodilator. SGTC_1513 0337-0559 19 µM 0.0714827774607796 0.477109309272351 no 1576 0.4715067655429 513 775073 SGTC_1364 1653-0028 37.6 µM 0.0706805814309711 0.477484641973366 no 1577 0.471825987975838 525 5718652 SGTC_754 3474-0146 171 µM 0.07043852787742 0.477597898296588 no 1578 0.471922313288492 521 24762078 SGTC_2666 tannic acid 100 µM 0.069626878418682 0.477977680439145 no 1579 0.472245321483879 517 16134267 A thiamine antagonist. SGTC_1069 diphenylcyclopropenone 8.49 µM 0.0696021551777324 0.477989249105262 no 1580 0.472255160759639 517 65057 A dermal irritant. YDR527W RBA50 SGTC_2361 9034121 116 µM 0.068345636525547 0.47857723202285 no 1581 0.472755248169867 517 6496917 SGTC_354 2783-3500 4.88 µM 0.0678167929244968 0.478824716303817 no 1582 0.472965737858594 520 6740761 SGTC_1241 0364-0022 50.8 µM 0.0665107802104773 0.479435929163756 no 1583 0.473485587674246 514 4563895 SGTC_2730 imipramine 71.33 µM 0.066299023099779 0.479535035908694 no 1584 0.473569880484441 523 3696 A tricyclic antidepressant. SGTC_3084 9116877 49.47 µM 0.064930222862655 0.480175693225059 no 1585 0.474114778497692 522 27241325 SGTC_2368 9071271 200 µM 0.0645266537702712 0.480364590747836 no 1586 0.474275442345489 518 27209959 SGTC_660 4031-1742 102 µM 0.0641750854712402 0.480529151991433 no 1587 0.474415407702795 516 6738706 SGTC_1739 st037196 92.5 µM 0.0640071742861559 0.480607748627595 no 1588 0.474482257134908 507 612214 SGTC_784 4579-0127 173 µM 0.0639720677491215 0.480624181551548 no 1589 0.474496233972256 521 1948547 SGTC_2649 anisomycin 9.56 µM 0.0636528409328594 0.480773609075946 no 1590 0.47462332801682 519 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2819 7996655 46.38 µM 0.0635267666673032 0.480832624178573 no 1591 0.474673522783761 522 6456960 SGTC_1695 st026914 34.495 µM 0.0629343948743572 0.481109917790837 no 1592 0.474909372985581 494 3289191 SGTC_1308 1187-1617 41.4 µM 0.0624513393325841 0.481336046430246 no 1593 0.475101705919215 531 2882570 SGTC_3135 9127742 49.47 µM 0.061559814800551 0.481753403863481 no 1594 0.47545668967946 531 3643468 SGTC_1792 st045773 43.6 µM 0.0615587663392274 0.481753894701015 no 1595 0.475457107163224 518 2919270 SGTC_1159 4092-0538 61.2 µM 0.0606560428625586 0.482176515196214 no 1596 0.475816569948808 522 717301 SGTC_1557 sumaresinolic acid 42.3 µM 0.0596630301370771 0.482641428769934 no 1597 0.476212008466343 508 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_645 0845-0943 5.41 µM 0.0585285680225768 0.483172595664871 no 1598 0.476663803750591 512 1885106 SGTC_1008 4106-0037 6 µM 0.0578259944740161 0.483501562902528 no 1599 0.476943616111652 532 2905394 SGTC_2245 6637752 200 µM 0.0576049204970734 0.483605079089892 no 1600 0.477031665096935 506 681890 SGTC_2273 7815444 169.05 µM 0.0575514464698291 0.483630118057627 no 1601 0.477052962814428 536 2824616 SGTC_2798 7813637 45.45 µM 0.0568774326300074 0.483945727445826 no 1602 0.477321415678691 527 956368 SGTC_1801 st050089 28.441 µM 0.0565409380668362 0.484103296003861 no 1603 0.477455441903482 497 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_3110 9122132 49.47 µM 0.0564740573578608 0.484134614181943 no 1604 0.477482080881637 521 918317 SGTC_1603 st002045 67.8 µM 0.0563011481321744 0.484215582705042 no 1605 0.477550952105117 521 5887985 SGTC_1035 k081-0041 55.2 µM 0.0558065053881418 0.484447213561005 no 1606 0.477747976236123 529 731709 SGTC_1236 0330-0013 258 µM 0.0541007392321372 0.485246027958941 no 1607 0.478427451644906 516 4617066 SGTC_3250 9135583 49.47 µM 0.0538301888970577 0.485372732855397 no 1608 0.478535228560092 499 7699353 SGTC_1280 0880-0253 10.1 µM 0.0536468103992331 0.485458614031518 no 1609 0.478608280439328 519 6836607 SGTC_358 0075-0058 9.45 µM 0.0526462296220857 0.485927225207216 no 1610 0.479006891053657 526 1069125 SGTC_2810 7959871 45.46 µM 0.0525763338058843 0.485959960889806 no 1611 0.479034736885385 514 2974535 SGTC_1325 1431-0015 227 µM 0.0524286713610399 0.486029118858216 no 1612 0.479093564542313 495 1103340 SGTC_1049 3226-0134 66 µM 0.0507025235326736 0.486837593877238 no 1613 0.479781282874686 520 5702385 SGTC_2692 st077426 47.7 µM 0.0505243978605098 0.486921025647574 no 1614 0.479852253774329 530 25238571 SGTC_108 0509-0257 621.132 µM 0.0503448673306812 0.487005116014365 no 1615 0.479923785059972 499 536624 SGTC_1372 2752-0194 270 µM 0.0501709875409304 0.487086560179877 no 1616 0.479993065508119 524 823334 SGTC_439 amiodarone 34.4 µM 0.0501189187983868 0.487110948946041 no 1617 0.480013811831117 513 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_2260 7964312 200 µM 0.0499593498594541 0.487185690623299 no 1618 0.480077390979191 501 231951 SGTC_574 1315-0397 40 µM 0.0498911518777047 0.487217634518566 no 1619 0.48010456415145 531 6794277 SGTC_635 k038-0028 24.7 µM 0.0482571815511666 0.487983009328255 no 1620 0.480755639471255 523 4035102 SGTC_546 peri-Naphthalide 147 µM 0.0475331796289314 0.488322156385687 no 1621 0.481044143346499 517 223824 A penicillin ester. SGTC_1261 0712-0010 12.7 µM 0.0470600566660684 0.488543787806685 no 1622 0.48123268110382 528 2840123 SGTC_2581 avocatin a 64 µM 0.046879838384276 0.488628210840419 no 1623 0.48130449853138 522 6710728 A skin care supplement. SGTC_2482 5981709 142.65 µM 0.04629861272173 0.48890048874376 no 1624 0.481536122506514 517 877755 SGTC_1328 1441-0025 69.2 µM 0.0457493259764131 0.489157809467202 no 1625 0.481755024248257 501 4562601 SGTC_768 0384-0033 77.3 µM 0.0450565870557388 0.489482338702678 no 1626 0.482031102383117 511 3965305 YMR134W ERG29 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.0449643148590742 0.489525566233055 no 1627 0.482067876393804 530 6708514 SGTC_1207 2099-0101 141 µM 0.0446299817069393 0.489682195117589 no 1628 0.482201122258345 523 5837381 SGTC_3 0833-0587 95.581 µM 0.0444730396383794 0.489755720117847 no 1629 0.482263670979679 514 5382644 SGTC_2795 7780010 54.55 µM 0.0437392165882712 0.490099509765987 no 1630 0.48255613939895 527 953673 SGTC_3174 9107204 49.47 µM 0.0432799160954986 0.490314691768119 no 1631 0.482739200426485 505 3938802 SGTC_1633 st005664 67.9 µM 0.0430434146343683 0.490425493662538 no 1632 0.48283346301531 523 2063822 SGTC_905 2-aminofluorene 215 µM 0.0427300337629079 0.490572315009461 no 1633 0.482958368973499 527 1539 An established DNA mutagen. YPR165W RHO1 SGTC_2131 toluylene red 5.2905 µM 0.0422156068334807 0.490813330740097 no 1634 0.483163410598693 518 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_676 falcarinol 140 µM 0.0415855469521734 0.491108526578794 no 1635 0.483414547568233 534 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_2115 tiliquinol 12.7705 µM 0.040424915871375 0.491652318419429 no 1636 0.483877183244304 530 71208 A bioactive hydroxyquinoline. SGTC_1534 6-azauridine 81.6 µM 0.0403036521711789 0.491709135155605 no 1637 0.483925521067503 530 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_882 0843-0131 351 µM 0.0400531463151991 0.491826507374522 no 1638 0.484025377812584 519 5425421 SGTC_2096 5468907 200 µM 0.0395329372290627 0.492070248814854 no 1639 0.484232746961254 534 759785 SGTC_2648 atorvastatin 78.68 µM 0.0393337514911389 0.49216357711364 no 1640 0.484312148815138 531 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_1840 st055363 71 µM 0.0389517110401583 0.492342583020245 no 1641 0.484464444188294 511 676033 SGTC_2126 5251174 33.877 µM 0.0384904655946084 0.492558702655424 no 1642 0.484648316602816 518 790722 SGTC_2276 7947513 42.08 µM 0.0378597025702339 0.492854254408226 no 1643 0.484899771344061 513 2105100 SGTC_1120 ficusin 1.78878 µM 0.0377566576678684 0.492902537738375 no 1644 0.484940850941092 516 6199 A DNA cross-linker. SGTC_3062 9077494 49.47 µM 0.0377405412735307 0.492910089341042 no 1645 0.484947275872945 513 16459633 SGTC_2480 5767542 37.17 µM 0.0368579391265899 0.493323650955517 no 1646 0.485299138328184 531 2867358 SGTC_716 1683-5115 658 µM 0.0368167730428973 0.493342940359842 no 1647 0.48531555008041 539 723597 SGTC_421 streptovitacin 30 mM 0.0362363867443217 0.493614896599419 no 1648 0.485546936302423 510 91467 include heat shock SGTC_2561 acetosyringone 100 µM 0.0362202533392512 0.493622456400762 no 1649 0.485553368377426 533 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_3295 9122362 53.5725 µM 0.035627535642348 0.49390019400649 no 1650 0.485789675993816 521 4730473 SGTC_1935 st074532 41.6 µM 0.0350076300746099 0.494190674555322 no 1651 0.486036828342138 531 2829742 SGTC_1457 k015-0032 57.3 µM 0.0345886139024116 0.494387022420929 no 1652 0.486203890429035 522 4302660 SGTC_613 3914-0030 117 µM 0.0344306034848516 0.494461065284455 no 1653 0.486266889940635 530 1145395 SGTC_1369 1866-0067 208 µM 0.034384605397817 0.494482619785845 no 1654 0.48628522966311 528 3531355 SGTC_1003 4049-0218 100 µM 0.0333984033647099 0.494944753495313 no 1655 0.486678441442125 528 295161 SGTC_1578 josamycin 24.2 µM 0.0327944244006866 0.495227781082249 no 1656 0.486919262253303 516 5282165 A P450 substrate. SGTC_506 n9-isopropylolomoucine 153 µM 0.0325658132179984 0.495334910069183 no 1657 0.487010416230877 538 6610355 SGTC_1010 4112-3296 15.2 µM 0.032544864520879 0.495344726809323 no 1658 0.487018769124297 525 704384 SGTC_880 0833-0487 87.2 µM 0.0324038112377361 0.4954108256674 no 1659 0.487075011578708 535 76075 SGTC_1652 st011932 78 µM 0.0309839656828183 0.496076184987285 no 1660 0.487641163532708 532 1551076 SGTC_284 0988-0104 32.6 µM 0.0307599453082065 0.496181165086345 no 1661 0.487730492152926 529 4666532 SGTC_2849 9019321 12.99 µM 0.0304927590814643 0.496306373848846 no 1662 0.48783703405674 541 16489627 SGTC_2558 carylophyllene oxide 100 µM 0.0300208541253079 0.496527518747401 no 1663 0.488025210739157 538 6708694 An oxygenated terpenoid and antifungal agent. SGTC_2719 novobiocin 32.65 µM 0.0299278781413696 0.496571089438194 no 1664 0.48806228613103 525 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_1888 azatryptophan 97.5 µM 0.0298327656175648 0.496615661403171 no 1665 0.488100213602916 497 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_744 1594-0068 283 µM 0.0283590973484947 0.497306262058321 no 1666 0.488687873328432 528 668392 SGTC_2713 st079149 53.4 µM 0.0272287851806856 0.497835962372816 no 1667 0.489138628479717 536 3103253 SGTC_3117 9124945 49.47 µM 0.0272127812504473 0.497843462354302 no 1668 0.489145010759161 542 17592065 SGTC_781 4335-2806 94.4 µM 0.0270425342770575 0.497923245874732 no 1669 0.489212904488448 529 845254 SGTC_3091 9116372 49.47 µM 0.0265587905197765 0.498149945090163 no 1670 0.489405821028172 527 17169793 SGTC_1295 1013-0063 9.78 µM 0.0265547407910676 0.498151842937063 no 1671 0.489407436066565 531 6826038 SGTC_138 0850-0259 40.9225 µM 0.0261932050206569 0.498321271620416 no 1672 0.489551617816318 530 6813004 SGTC_2462 5162487 171.77 µM 0.0260257362806109 0.498399753608145 no 1673 0.48961840540871 536 2259986 SGTC_1653 st012112 65 µM 0.0255493532114301 0.498623004497734 no 1674 0.489808391574215 535 720429 SGTC_489 paxilline 115 µM 0.0242526455829426 0.499230692079635 no 1675 0.490325542679163 516 105008 A toxic potassium channel blocker. SGTC_559 1550-0661 158 µM 0.024093641085914 0.49930520791675 no 1676 0.490388957765015 534 5830875 SGTC_1748 st037455 53.6035 µM 0.0233872714428695 0.499636241108311 no 1677 0.490670679073805 536 580690 SGTC_2331 7980721 200 µM 0.023094616061526 0.499773391263205 no 1678 0.49078740015139 533 2981221 SGTC_695 3505-6186 243 µM 0.0221275263572544 0.499773391263205 no 1679 0.491173114495471 534 1819379 SGTC_3212 9128307 49.47 µM 0.0220169156228355 0.49972155459283 no 1680 0.49121723104635 520 27243542 SGTC_1307 1187-1599 12.2 µM 0.021712904828802 0.499579082847804 no 1681 0.491338484817702 540 1538471 SGTC_2514 salinomycin 42.74 µM 0.0214019096675379 0.499433338001703 no 1682 0.491462525110567 537 23682228 A polyether potassium ionophore. SGTC_2034 5197015 53.07 µM 0.0202067235627915 0.49887322657762 no 1683 0.491939232177089 541 780676 SGTC_2846 9008642 19.48 µM 0.0189623358031556 0.498290059690584 no 1684 0.492435575839226 538 2992898 SGTC_1502 4534-4282 27.7 µM 0.018917338124421 0.498268972147588 no 1685 0.492453524096327 543 3278949 SGTC_2909 7941780 10.49 µM 0.0165786893346757 0.497173004606747 no 1686 0.493386362835082 533 1243215 SGTC_2271 7849410 118.62 µM 0.0165581919254109 0.497163398930598 no 1687 0.493394538995967 541 972430 SGTC_191 3914-0123 66.505 µM 0.016390952626989 0.497085025842102 no 1688 0.493461248769459 541 3144412 SGTC_990 3985-0011 41.3 µM 0.0150316826881724 0.496448037755455 no 1689 0.494003452052445 543 5399565 YGL099W LSG1 SGTC_1380 2291-0730 164 µM 0.0143934945729486 0.496148969775575 no 1690 0.494258024716214 536 2999191 SGTC_1884 5633444 25 µM 0.0138054622801218 0.495873407749997 no 1691 0.494492592340056 541 5724239 SGTC_2887 9044784 58.44 µM 0.0114136585753515 0.494752589157637 no 1692 0.495446707881217 544 6465546 SGTC_796 1234-0020 70.7 µM 0.0112731631571571 0.494686753068223 no 1693 0.495502753837776 546 46495034 SGTC_2058 5236698 133 µM 0.0111906217297715 0.494648074260058 no 1694 0.495535681025998 542 766665 SGTC_883 0850-0245 24.6 µM 0.0104310136242243 0.494292125274137 no 1695 0.495838703100367 547 6823229 YPR165W RHO1 SGTC_115 0527-0192 112.043 µM 0.00960967813790101 0.493907256233682 no 1696 0.496166352093453 546 4233931 SGTC_1454 4239-0054 42.6 µM 0.00937365095854452 0.493796657450529 no 1697 0.496260509072927 545 1340767 SGTC_1827 berberine 7.24 µM 0.00894364544309255 0.493595164570885 no 1698 0.496432049257907 541 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2477 5967686 25.23 µM 0.00876058477568886 0.493509386115169 no 1699 0.496505077036628 540 776118 SGTC_1209 2323-2347 50.3 µM 0.00814363228866963 0.493220297128889 no 1700 0.496751196673475 546 5412760 SGTC_1076 itraconazole 331 nM 0.0077797996017722 0.493049815607036 no 1701 0.496896340314147 545 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_2344 7990960 76.95 µM 0.00642716653015637 0.492416022073719 no 1702 0.497435949180788 540 140813 SGTC_294 k038-0071 157 µM 0.00642453038206047 0.492414786890971 no 1703 0.497437000830008 545 24152826 SGTC_2629 bisabolol 100 µM 0.00550577378950652 0.491984302580695 no 1704 0.497803525146202 545 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_1377 2944-0135 198 µM 0.00530869152064054 0.491891960687647 no 1705 0.497882148446434 546 1894137 SGTC_124 0136-0217 7.121 µM 0.0046152801005381 0.491567069786214 no 1706 0.498158776168596 543 3976905 SGTC_2313 7726885 200 µM 0.00441095266675545 0.49147133529301 no 1707 0.498240290190684 547 726423 SGTC_3278 9139605 49.47 µM 0.00425514016810927 0.491398332060323 no 1708 0.498302449800611 539 7958859 SGTC_2229 7354935 190 µM 0.00412768399565961 0.491338614904568 no 1709 0.498353297010022 546 318112 SGTC_2418 pentamidine 31.67 µM 0.00355424952458454 0.491069945553998 no 1710 0.498582062574941 544 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1326 1431-2094 10.8 µM 0.00340287684156517 0.490999024083859 no 1711 0.498642451172873 544 616278 SGTC_1385 3091-4834 14.1 µM 0.0018360897484956 0.490264966594523 no 1712 0.49926750658028 546 4072814 SGTC_1683 st010134 710 nM 0.00115410417296652 0.489945458785246 no 1713 0.499539579151626 546 3818134 SGTC_2967 9089538 49.85 µM 0.00025800210541088 0.489525648004062 no 1714 0.499897072052861 547 728216 SGTC_1011 4112-3381 17.4 µM 1.92357078450843e-05 0.489413791359291 no 1715 0.499992326062848 547 2877139 SGTC_1720 st037298 9.481 µM 8.26105057084975e-06 0.489408650001085 no 1716 0.499996704317647 548 597396 SGTC_904 1141-0088 396 µM -7.35412930900253e-06 0.4894013346747 no 1717 0.499997066126883 549 1378119 SGTC_1569 carminic acid 40.6 µM -1.72132007365678e-05 0.489396715944899 no 1718 0.499993132926445 548 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_1214 0358-0031 63.7 µM -2.01676014584831e-05 0.489395331881903 no 1719 0.499991954291084 549 4301366 SGTC_51 1013-0126 23.419 µM -0.000646790185113965 0.489101777754564 no 1720 0.4997419680666 551 1627850 SGTC_1127 asiatic acid 681.4 nM -0.000796632706442336 0.489031581838551 no 1721 0.499682189565065 550 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_2097 5376186 200 µM -0.000847320361583765 0.489007836543528 no 1722 0.499661968123168 549 742755 SGTC_2139 5578692 56.4705 µM -0.00172632584270082 0.488596061198086 no 1723 0.499311295973676 549 650991 YMR113W FOL3 SGTC_1727 st034309 9.9045 µM -0.00179775766304845 0.488562599065156 no 1724 0.499282798844619 550 870305 SGTC_1920 st075728 45.7 µM -0.00223118444904595 0.488359562648979 no 1725 0.499109886926426 550 3400306 SGTC_336 4111-0029 111 µM -0.0036497421883662 0.487695068378289 no 1726 0.49854396676104 553 3131175 SGTC_423 5-fluorouracil 457 µM -0.005117459994346 0.487007582059652 no 1727 0.49795843775087 550 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_738 1315-0003 72.4 µM -0.0057305514552632 0.48672041828543 no 1728 0.497713853247032 551 6251474 SGTC_3129 9127257 49.47 µM -0.00599206551995021 0.486597930709657 no 1729 0.497609526022099 556 837894 SGTC_396 dithiazanine 1.25 µM -0.00695442947468908 0.486147191061719 no 1730 0.497225606409998 550 10578 An antihelmenthic. SGTC_1090 efavirenz 20.7 µM -0.00850971436158301 0.485418784396382 no 1731 0.496605156120146 549 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_398 bronopol 33.3 µM -0.00890399164513233 0.485234135055929 no 1732 0.496447868204611 554 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_20 0481-0013 4.944 µM -0.00892655760678284 0.485223566979882 no 1733 0.496438866046173 554 182045 SGTC_941 3237-0776 460 µM -0.0114030187753683 0.484063857044436 no 1734 0.495450952271072 558 760008 SGTC_2808 7946468 45.46 µM -0.0115295633789921 0.484004600603241 no 1735 0.495400471596967 558 2970879 SGTC_2885 9057732 51.95 µM -0.0119309416957532 0.483816651426612 no 1736 0.495240355833299 561 6471414 SGTC_1405 3909-7894 12 µM -0.0128229707318703 0.483398963366811 no 1737 0.494884515003745 552 7104060 SGTC_998 3996-0085 177 µM -0.01539943391757 0.482192651501323 no 1738 0.49385675752104 551 715391 SGTC_867 0518-0118 155 µM -0.0156447578790132 0.482077798025114 no 1739 0.493758899210148 554 6848158 SGTC_2239 6685329 187.64 µM -0.017824403433637 0.481057418384019 no 1740 0.492889468363123 569 805680 SGTC_1701 st028638 40.4 µM -0.0186686883293159 0.480662207685806 no 1741 0.492552703496847 556 3490878 SGTC_2610 ononetin 44.17 µM -0.0189085953008639 0.480549910416578 no 1742 0.492457011354541 566 259632 SGTC_1772 st048439 82.2 µM -0.0195015002742487 0.480272386107791 no 1743 0.492220520112872 559 2927068 YDL195W SEC31 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.0197678389686834 0.480147722587035 no 1744 0.492114286826584 558 6708561 SGTC_3207 9114163 49.47 µM -0.0201903638337744 0.479949957950786 no 1745 0.491945757433463 561 849233 SGTC_3021 9087658 49.47 µM -0.021020370414783 0.479561484106179 no 1746 0.491614703011983 555 25237042 SGTC_2911 7942208 15.64 µM -0.0213018027014971 0.47942976775327 no 1747 0.491502452909252 558 1243384 SGTC_2375 9072683 200 µM -0.0216986028535296 0.479244060581849 no 1748 0.491344189136407 559 16798029 SGTC_3294 9122953 26.2835 µM -0.0235465517395962 0.478379258611838 no 1749 0.490607152923278 553 16459826 SGTC_2217 6934799 96.0675 µM -0.0244197033216025 0.477970676837763 no 1750 0.490258916016742 563 675606 SGTC_1140 3229-1848 2.98 µM -0.0256139417342909 0.477411883551855 no 1751 0.489782632911502 559 2849525 SGTC_1799 st045822 46.1415 µM -0.0259063762899243 0.477275057913354 no 1752 0.489666007105459 561 3674992 SGTC_1334 1486-0610 236 µM -0.0259329001065181 0.477262647959083 no 1753 0.489655429187448 557 3742339 SGTC_2981 9013952 38.96 µM -0.0270512740984909 0.476739403732349 no 1754 0.489209419079237 557 2996344 SGTC_2958 9077254 16.72 µM -0.0270994159775547 0.476716880890403 no 1755 0.489190220286583 565 16457351 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.027161146995107 0.476688000573754 no 1756 0.489165602235426 569 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_2586 curcumin 80 µM -0.0280740893267872 0.476260902865959 no 1757 0.488801529823858 574 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_2116 5511452 16.8835 µM -0.0281325383876764 0.476233559828166 no 1758 0.488778221228562 571 870744 SGTC_1987 st072290 61.9 µM -0.0285389194287286 0.476043453935156 no 1759 0.48861616372259 564 54697379 SGTC_2299 7976368 114.88 µM -0.0285880452258429 0.476020473154055 no 1760 0.488596573358315 562 2979718 SGTC_3337 9144342 33.5465 µM -0.0294372308224894 0.475623241415034 no 1761 0.488257939879585 560 17682949 SGTC_500 h-89 112 µM -0.0300795618492179 0.475322788106092 no 1762 0.488001800318274 561 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_1135 dihydrocapsaicin 536.708 nM -0.0302501018745745 0.47524301957069 no 1763 0.48793379563809 578 107982 A Capsaicinoid. SGTC_3097 9117246 49.47 µM -0.0307681651581739 0.475000706312285 no 1764 0.487727214458652 565 16423892 SGTC_2853 9015042 58.44 µM -0.0316909627990675 0.474569109990842 no 1765 0.487359250955017 558 6457456 SGTC_2460 5552655 174.22 µM -0.0326309241287305 0.474129516824435 no 1766 0.486984454533487 572 5401989 SGTC_1609 st001574 46.4 µM -0.0330994611239001 0.473910407134308 no 1767 0.48679763623831 568 3960012 SGTC_1632 st005650 90 µM -0.0331488316741365 0.473887319627313 no 1768 0.486777951040767 568 2759605 SGTC_3048 9093155 49.47 µM -0.0336405734196553 0.473657367682997 no 1769 0.486581883827584 554 25236002 SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.0337726782915992 0.473595593309596 no 1770 0.486529211538716 571 77254 SGTC_188 3229-0966 278.469 µM -0.0337846154705482 0.47359001132303 no 1771 0.486524452009403 561 5722370 SGTC_2270 7924575 90.91 µM -0.0352604001576455 0.472899954707026 no 1772 0.485936049888673 587 1262135 SGTC_3050 9093513 49.47 µM -0.0363338739786845 0.47239806408917 no 1773 0.485508070117093 561 25236664 SGTC_295 k015-0027 31 µM -0.0365265113437157 0.472308003269178 no 1774 0.48543126990747 564 3887424 SGTC_1203 3992-3522 103 µM -0.0377952936385193 0.471714864347556 no 1775 0.484925448412669 566 5322312 SGTC_2957 9076800 11.52 µM -0.0380860453347089 0.471578950566654 no 1776 0.484809538724072 573 16459615 SGTC_3290 9121031 71.43 µM -0.0387071005693099 0.47128864534347 no 1777 0.484561956108915 564 17014854 SGTC_712 r015-0009 80.6 µM -0.0393549467998585 0.470985833232226 no 1778 0.484303699652433 579 6813872 YLR060W FRS1 SGTC_1363 1636-0063 10.4 µM -0.0395644252861672 0.470887923728198 no 1779 0.484220194864143 562 6072185 SGTC_3161 9100388 49.47 µM -0.0419315356950074 0.469781668388187 no 1780 0.483276638324694 569 25236368 SGTC_2011 4012611 177 µM -0.0428535139356757 0.469350849833898 no 1781 0.482909152593397 564 2049887 SGTC_2747 doxorubicin 7.63 µM -0.0428714486904015 0.469342469702734 no 1782 0.482902004230924 565 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_3305 9127027 53.8275 µM -0.0440240741563628 0.468803926580214 no 1783 0.482442607033061 576 41905295 SGTC_617 3770-0098 35 µM -0.0443112098821144 0.468669776517194 no 1784 0.48232816812929 567 5962639 SGTC_3158 9100007 49.47 µM -0.0445175507759342 0.468573376066263 no 1785 0.482245931174567 570 19297233 SGTC_3098 9119039 49.47 µM -0.0450839843958315 0.468308753298118 no 1786 0.482020183521327 557 17161528 SGTC_2794 7785382 27.27 µM -0.0452646297306571 0.468224363526704 no 1787 0.481948189956379 569 2205081 SGTC_628 1636-0253 16 µM -0.0467360768822139 0.467537019893359 no 1788 0.481361788277923 572 4456143 SGTC_482 fipronil 114 µM -0.0470291918069555 0.467400111296991 no 1789 0.48124498078276 562 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_1315 1237-0019 3.69 µM -0.0473034365833293 0.467272020091934 no 1790 0.481135694576653 565 825140 SGTC_954 1189-0853 2.85 µM -0.0474619118568238 0.467198002765025 no 1791 0.48107254302087 574 2828194 SGTC_3217 9129673 49.47 µM -0.0478382836554473 0.467022219422112 no 1792 0.480922562762293 584 17248312 SGTC_3209 9113616 49.47 µM -0.0485085911359089 0.466709170231944 no 1793 0.480655458883668 574 16649353 SGTC_2680 butyl paraben 22.24 µM -0.0488690624062708 0.466540830263822 no 1794 0.48051182200769 575 7184 An antifungal and steroid mimetic. SGTC_3011 9081274 71.4286 µM -0.0495064334253238 0.466243192868278 no 1795 0.480257855178146 570 6625322 SGTC_609 0986-0026 86.3 µM -0.0503901461921347 0.465830550892346 no 1796 0.479905744305917 576 2848610 SGTC_2541 muurolladie-3-one 83.07 µM -0.0509455825152368 0.465571213512631 no 1797 0.47968444152564 585 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_540 1187-0821 17.3 µM -0.0512872281780186 0.46541170384899 no 1798 0.479548322574427 567 847520 SGTC_2702 st077768 96.8 µM -0.0523877194703198 0.46489793750036 no 1799 0.47910987956202 567 6484119 SGTC_2912 7964298 10.93 µM -0.0524703673031832 0.464859355561762 no 1800 0.47907695313239 574 2975850 SGTC_1123 mangostin 811.285 nM -0.052637591820754 0.464781292262342 no 1801 0.479010332266419 571 5281650 An antioxidant. SGTC_1624 st003710 6.25 µM -0.0534929170374073 0.464382032907462 no 1802 0.478669586978217 570 24207033 SGTC_2399 5884133 200 µM -0.0542313539521733 0.464037364960461 no 1803 0.478375420295656 577 722445 SGTC_3309 9129340 25.759 µM -0.054864125664188 0.46374203806823 no 1804 0.478123356191994 574 17158987 SGTC_1276 0871-0068 94.2 µM -0.0556327476688272 0.463383334084368 no 1805 0.477817188013283 578 3414906 SGTC_26 0302-0163 425.158 µM -0.0571104446904053 0.462693799650005 no 1806 0.477228608172369 581 3100915 SGTC_2484 5809818 12.04 µM -0.0587976210356511 0.461906653512524 no 1807 0.476556651661429 575 2870548 SGTC_1078 idebenone 36.1 µM -0.0589674875673754 0.461827411099761 no 1808 0.476489002097461 572 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.0592246512620598 0.46170744761165 no 1809 0.476386587616549 569 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_3043 9092303 49.47 µM -0.0603518849434007 0.461181649143027 no 1810 0.475937689506222 583 25236084 SGTC_2432 5630864 12.22 µM -0.0604615620770683 0.4611304938204 no 1811 0.47589401441776 593 5714970 SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.0606545076084374 0.461040502230389 no 1812 0.475817181300952 586 75037 A free radical scavenger. SGTC_151 3013-0144 2.285 µM -0.0610734599895923 0.460845105819299 no 1813 0.475650352772044 568 906558 YHR107C CDC12 SGTC_2311 7694451 200 µM -0.0614154314190549 0.460685619781727 no 1814 0.475514181531567 571 2163142 SGTC_1872 amphotericin b 148 nM -0.0614835247329493 0.4606538636934 no 1815 0.475487067469871 571 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_782 0083-0095 30.5 µM -0.061779570589932 0.46051580227392 no 1816 0.47536918635637 614 3591729 An indicator and reagent. SGTC_2028 5153890 36.43 µM -0.0629864911558817 0.45995300252965 no 1817 0.474888630728334 592 2830968 YPR165W RHO1 SGTC_2422 chlorphenesin carbamate 384.24 µM -0.0639949225023156 0.459482821868567 no 1818 0.474487134889286 570 2724 A muscle relaxant with antifungal properties. SGTC_2238 6671620 73.2395 µM -0.0640608285552403 0.459452095166578 no 1819 0.474460896017436 579 729941 SGTC_70 0141-0289 43.283 µM -0.0651417415290702 0.458948186909434 no 1820 0.474030573028212 573 352408 SGTC_2342 7990637 118.86 µM -0.0657403155590168 0.458669167423604 no 1821 0.473792287322557 598 2033102 YER133W GLC7 SGTC_1473 k844-0725 134 µM -0.066978467584807 0.458092079623962 no 1822 0.473299422538867 567 54682906 SGTC_2483 5729050 27.16 µM -0.0672286047438923 0.457975504381874 no 1823 0.473199856669814 586 2865180 SGTC_704 1310-0270 142 µM -0.0687825854781386 0.457251360374141 no 1824 0.472581340014837 586 5718033 SGTC_783 0848-0141 92.7 µM -0.0688025896730846 0.4572420394811 no 1825 0.472573378356949 574 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_2627 acetyl isogambogic acid 100 µM -0.0688099464623985 0.457238611613686 no 1826 0.47257045036186 598 6857789 A caspase activator and apoptosis inducer. SGTC_1071 trifluoperazine 6.31 µM -0.0690703096313254 0.45711729845668 no 1827 0.472466827026079 600 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_2031 5180455 200 µM -0.0698934014961046 0.456733814817986 no 1828 0.472139252565143 573 29949 SGTC_335 4077-0256 27.6 µM -0.0700355539589791 0.456667589168121 no 1829 0.472082680567826 594 3121989 SGTC_1936 st074407 74.3 µM -0.0705478232985143 0.456428944348449 no 1830 0.471878818926353 569 809813 SGTC_3099 9120367 49.47 µM -0.0714330919766593 0.456016571860765 no 1831 0.471526536640792 567 24824940 SGTC_3067 9117431 49.47 µM -0.0719672223009416 0.455767788191119 no 1832 0.471313996501599 587 17150885 SGTC_2659 sanguinarine 24.21 µM -0.0720553079986696 0.455726761883969 no 1833 0.471278946388729 583 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_1565 sinapyl alcohol 95.1 µM -0.0723712853028958 0.455579597930347 no 1834 0.471153217932572 580 5280507 A phenol propionate derived from cinnamic acid. SGTC_459 nigericin 15.3 µM -0.072538621636064 0.45550166481153 no 1835 0.471086635393728 603 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_686 1319-0111 510 µM -0.0728342235849372 0.455363999064244 no 1836 0.470969018393221 585 4562600 SGTC_3066 9117245 49.47 µM -0.0731442782719523 0.455219608244608 no 1837 0.470845653516794 595 17176980 SGTC_806 3966-4455 5.86 µM -0.073735950821805 0.454944085914119 no 1838 0.470610246010038 617 714982 SGTC_60 0986-0278 202 µM -0.0739079726668991 0.454863985093098 no 1839 0.470541805965509 579 3110598 SGTC_46 0329-0187a 2.197 µM -0.07431358089787 0.454675123605606 no 1840 0.470380435459323 583 46494817 SGTC_1361 1608-0041 5.61 µM -0.0757483845854812 0.454007125101241 no 1841 0.469809640603641 577 X1361 SGTC_2475 5812728 15.03 µM -0.0760685765137229 0.453858071712392 no 1842 0.469682269996213 582 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.0762052079126881 0.453794470046594 no 1843 0.469627919712469 582 165521 SGTC_1167 k781-0610 148 µM -0.0762383183258752 0.453779057388251 no 1844 0.469614748884009 594 4525169 SGTC_1794 st048918 76.9 µM -0.0766051289314391 0.453608314361493 no 1845 0.469468839324403 580 672303 SGTC_281 1672-3440 14.9 µM -0.0768072058570302 0.453514255240875 no 1846 0.469388459115198 580 6833000 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.0769301863527409 0.453457013775071 no 1847 0.469339541730956 582 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_955 1216-0110 33 µM -0.0772040070845479 0.453329566958372 no 1848 0.469230626985568 579 3619719 SGTC_2373 9071805 200 µM -0.0775765084084038 0.453156198076384 no 1849 0.469082464814128 627 10149009 SGTC_1444 4112-3581 28 µM -0.0785362424997101 0.452709561612198 no 1850 0.468700750947518 569 2877249 SGTC_1783 st039459 87.517 µM -0.0797716473213879 0.4521347229703 no 1851 0.468209437300434 576 729761 SGTC_53 0973-0023 39.979 µM -0.0800764978459242 0.451992890228481 no 1852 0.468088207356262 602 674768 SGTC_1713 st033146 12.748 µM -0.0802870239765375 0.451894945806685 no 1853 0.468004489131832 600 674619 SGTC_2248 tofa 1.1 µM -0.0813864769895999 0.451383487937205 no 1854 0.467567301616074 578 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_2304 7443016 91.4 µM -0.081664377400384 0.451254223347958 no 1855 0.467456803211692 582 939854 SGTC_3178 9107506 49.47 µM -0.0819901771053368 0.451102685120754 no 1856 0.467327262345383 588 8897194 SGTC_410 α-linolenic acid 100 µM -0.0822004890449957 0.451004867150511 no 1857 0.467243642280771 574 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_126 0417-1624 672.48 µM -0.0824508904658346 0.450888407083543 no 1858 0.467144084516804 590 41912 YDL195W SEC31 SGTC_2470 5664817 21.68 µM -0.0845635402996033 0.449905996719264 no 1859 0.466304192914566 589 2859561 SGTC_2956 9076196 2.52 µM -0.0874432418556128 0.448567392506932 no 1860 0.465159599480449 598 16423868 SGTC_3187 9109394 49.47 µM -0.0876150796458369 0.448487533560832 no 1861 0.465091308224083 579 17098090 SGTC_1219 1469-0211 33.1 µM -0.0892146079678254 0.447744278164182 no 1862 0.464455678095885 597 6822282 SGTC_706 4262-0057 46.9 µM -0.0899571807329812 0.447399287873158 no 1863 0.464160620819758 598 883298 SGTC_2655 perillic acid 100 µM -0.0901252197533858 0.44732122449641 no 1864 0.464093854151789 591 5702197 An apoptosis inducer. SGTC_1060 3448-7350 82 µM -0.0901320447408777 0.44731805395706 no 1865 0.464091142412075 604 570178 SGTC_78 0336-0123 156.75 µM -0.0902077881364163 0.447282867684026 no 1866 0.464061047762149 577 6765896 SGTC_492 tmb-8 126 µM -0.0907732969627317 0.44702017608985 no 1867 0.463836364185173 611 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_43 0570-0105 72.5 µM -0.0920432492442298 0.446430339511451 no 1868 0.463331838742954 584 1114046 YDL195W SEC31 SGTC_2012 4023501 200 µM -0.0925992139067277 0.446172155772696 no 1869 0.463110984138922 595 3477460 SGTC_751 0833-0568 350 µM -0.0936028106268176 0.445706154588096 no 1870 0.462712338431026 582 6954252 SGTC_1971 st069429 63.5 µM -0.0937739492482386 0.445626697068159 no 1871 0.462644362982493 584 1246522 YGL099W LSG1 SGTC_528 3492-0019 172 µM -0.0965918232887095 0.444318709774941 no 1872 0.461525275100648 580 2869262 SGTC_656 4090-1979 187 µM -0.0976827822729842 0.443812475643562 no 1873 0.461092093959487 592 22330961 SGTC_3242 9133940 49.47 µM -0.0995457854368943 0.442948204750751 no 1874 0.46035246843954 618 17248444 SGTC_587 k089-0003 57 µM -0.0998743018381977 0.442795829839234 no 1875 0.460222059241975 592 9659696 SGTC_1196 1588-0294 184 µM -0.0999619695136311 0.442755168597645 no 1876 0.460187259050119 608 6144269 SGTC_3196 9111891 49.47 µM -0.101974840821614 0.441821743225827 no 1877 0.459388322538018 595 18891510 SGTC_2950 9072895 21.46 µM -0.102401523902157 0.44162391952389 no 1878 0.459218987066736 606 17332245 SGTC_1521 st012942 49.4 µM -0.102433027581877 0.441609314003321 no 1879 0.459206484659895 580 24207259 SGTC_2805 7950783 58.44 µM -0.102881239643417 0.441401525601912 no 1880 0.459028613638801 603 1178958 YDL195W SEC31 SGTC_1802 st050112 57.9 µM -0.102935488911085 0.441376377062462 no 1881 0.459007085606926 586 4662563 SGTC_65 0798-0905 34.986 µM -0.104027299591608 0.440870292612497 no 1882 0.458573842079037 667 3602145 SGTC_3227 9130768 49.47 µM -0.104154208348298 0.440811473141519 no 1883 0.458523486349816 593 17720899 SGTC_615 k087-0205 167 µM -0.104487702230887 0.44065691214872 no 1884 0.458391163528432 585 9642773 SGTC_119 0121-0043 24.815 µM -0.104563930352271 0.440621584750826 no 1885 0.458360918582767 595 1092378 SGTC_1490 4089-0339 670 nM -0.104807356486964 0.440508773750728 no 1886 0.458264336285086 601 742542 SGTC_2988 9073640 71.4286 µM -0.105519370245723 0.440178832886093 no 1887 0.457981850278618 605 9102229 SGTC_1750 st081859 2.357 µM -0.106232823761574 0.439848266511515 no 1888 0.457698814346786 613 5291695 SGTC_2998 9066762 71.4286 µM -0.106812504322166 0.439579712390694 no 1889 0.457468863607677 600 4945196 SGTC_567 1080-0542 68.4 µM -0.107496745256916 0.439262753377411 no 1890 0.457197453635528 585 5950415 SGTC_642 0335-0876 158 µM -0.107868816466697 0.439090416201931 no 1891 0.457049876804198 590 6812350 SGTC_2341 7987486 176.74 µM -0.108103273501971 0.438981825543235 no 1892 0.456956885747477 589 1258686 SGTC_317 4495-0002 170 µM -0.108147557149891 0.438961315731441 no 1893 0.456939322097898 606 15991618 SGTC_357 1325-0123 420 µM -0.108404148258017 0.438842479712843 no 1894 0.4568375553476 637 1098503 SGTC_2652 actinonin 100 µM -0.110091908683957 0.438060958660729 no 1895 0.456168242543182 591 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.110300016322011 0.437964610641116 no 1896 0.456085722160435 588 688664 SGTC_906 1165-0455 526 µM -0.111029099752876 0.437627094437845 no 1897 0.455796635561417 623 3252859 SGTC_2903 5923464 63.88 µM -0.111089609911044 0.437599084372661 no 1898 0.455772643916746 617 2876576 SGTC_1087 pterostilbene 9.05 µM -0.112589688856429 0.43690480030159 no 1899 0.45517793008394 591 5281727 Similar to reservatol, lowers cholesterol. SGTC_2202 7226349 200 µM -0.112713138427084 0.436847672551823 no 1900 0.455128992336324 592 844334 SGTC_2882 9058044 58.44 µM -0.112785999494452 0.436813955848572 no 1901 0.455100109148924 611 18076804 SGTC_963 1269-2853 151 µM -0.113014084189155 0.436708411859721 no 1902 0.455009694591951 578 3668223 SGTC_1868 st057644 42.7 µM -0.113147865595588 0.436646507902182 no 1903 0.454956663680138 599 688665 SGTC_3072 9116419 49.47 µM -0.113879422526623 0.436308025937576 no 1904 0.454666688939969 603 17170162 SGTC_1245 0418-0076 17.2 µM -0.114065275196577 0.436222041721429 no 1905 0.454593024448854 625 6790114 SGTC_1108 betulinic acid 729.144 nM -0.114291153362819 0.436117543879591 no 1906 0.454503497570332 589 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_2335 9018011 154.17 µM -0.116809192033625 0.434952929156041 no 1907 0.453505629715893 614 6458208 SGTC_1617 st002906 78 µM -0.117354668944164 0.434700715343409 no 1908 0.453289502360428 623 5150859 SGTC_1125 tnp00248 1.32998 µM -0.117712325137627 0.434535359181229 no 1909 0.453147800316406 618 24207736 SGTC_588 3970-1144 52.9 µM -0.11807872428882 0.434365972738607 no 1910 0.45300264053157 603 1888707 SGTC_936 3005-4620 401 µM -0.118910198973045 0.433981626474185 no 1911 0.452673250741432 594 777207 SGTC_3045 9092950 49.47 µM -0.118923781023185 0.433975348736059 no 1912 0.452667870464109 631 44120432 SGTC_2303 7774051 200 µM -0.119492505110314 0.43371249463335 no 1913 0.452442588774955 612 2953184 SGTC_1458 k015-0034 6.33 µM -0.119547061894423 0.43368728100239 no 1914 0.452420978669578 632 3598957 SGTC_2185 6113692 200 µM -0.119647979244148 0.433640642366177 no 1915 0.452381005377014 609 874150 SGTC_100 0086-0128 49.5915 µM -0.120149156440787 0.433409038599377 no 1916 0.452182496593686 652 93297 SGTC_2053 5265679 138 µM -0.120167111406171 0.433400741683142 no 1917 0.452175385122232 590 764595 SGTC_1112 tnp00069 1.16933 µM -0.120358617042789 0.433312249536686 no 1918 0.452099535924458 612 145826 SGTC_2769 toremifene 3.73 µM -0.121479392462363 0.43279442166092 no 1919 0.451655668121948 602 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_3184 9108758 49.47 µM -0.121489878213731 0.432789577510009 no 1920 0.451651515667753 587 902885 SGTC_505 gw-5074 63.9 µM -0.12219378411927 0.432464413986509 no 1921 0.451372774560268 594 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_2907 7721985 69.9 µM -0.122332273392222 0.432400445387016 no 1922 0.45131793673418 611 3267881 SGTC_3165 9101544 49.47 µM -0.122592341499807 0.432280323958121 no 1923 0.451214959647444 611 5002184 SGTC_3010 9080089 71.4286 µM -0.122767304778344 0.432199514652372 no 1924 0.45114568268553 608 17027233 SGTC_949 1165-0505 146 µM -0.122830344715214 0.432170399446071 no 1925 0.451120722296362 597 6244267 SGTC_2850 9015429 58.44 µM -0.123588641900055 0.43182020625787 no 1926 0.450820492993124 593 6457570 SGTC_2771 fluoxetine 41.05 µM -0.124358546995578 0.431464707167289 no 1927 0.450515696605809 597 3386 A selective serotonin reuptake inhibitor. SGTC_2517 totarol 10 µM -0.124682464331625 0.431315156839511 no 1928 0.450387470246792 601 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_1961 st076550 68.7 µM -0.124859496305943 0.431233426597085 no 1929 0.450317392315366 607 1579337 SGTC_217 ketoconazole 989 nM -0.125629474632603 0.430877985474747 no 1930 0.450012615206403 595 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_1910 st062352 60.4 µM -0.125749214564086 0.430822715570539 no 1931 0.44996522172416 602 2245730 SGTC_2109 5483026 200 µM -0.126550393059784 0.430452940194109 no 1932 0.449648130876884 597 759335 SGTC_2495 cafestol 54.53 µM -0.126594048917448 0.43043279304822 no 1933 0.449630853660307 646 16667697 An anti-infammatory. SGTC_1342 1486-1464 234 µM -0.12749343883114 0.430017765641807 no 1934 0.449274932930494 612 3253938 SGTC_1448 4255-0083 152 µM -0.128162165573664 0.429709228850622 no 1935 0.449010320297302 651 5399660 SGTC_2679 rapamycin 1 nM -0.128586850027692 0.429513310435918 no 1936 0.448842286037781 619 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_937 3122-0005 46.7 µM -0.128605757756287 0.429504588193067 no 1937 0.448834805058369 599 759535 SGTC_2880 9042983 58.44 µM -0.129649862757204 0.429022990148046 no 1938 0.448421725683519 634 6464714 SGTC_1716 st033144 30.6155 µM -0.130270810887447 0.42873662512942 no 1939 0.448176086393606 611 674617 SGTC_254 nsc-64875 3.808 µM -0.13078191579168 0.428500945068783 no 1940 0.447973914609674 629 56993 SGTC_1504 k297-0033 30 µM -0.131009177251763 0.428396158729633 no 1941 0.447884023791379 610 4388117 SGTC_123 0083-0120 66.675 µM -0.131928137395511 0.427972493610311 no 1942 0.447520566360707 605 16001701 SGTC_887 0885-0007 9.62 µM -0.132938520215031 0.427506776037059 no 1943 0.447121001263367 617 5719458 SGTC_1074 carmofur 3.8 µM -0.133401341129404 0.427293480846881 no 1944 0.446937992410488 613 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2257 7960413 200 µM -0.133837528032259 0.427092479632233 no 1945 0.446765525531852 603 2974689 YIL048W NEO1 SGTC_2173 5763948 167 µM -0.134152649684335 0.426947278804126 no 1946 0.446640933720818 590 2867177 SGTC_3009 9080819 71.4286 µM -0.134290681769555 0.426883679901989 no 1947 0.446586360685727 628 17027216 SGTC_2739 tacrine 100.86 µM -0.135554378719311 0.426301514424904 no 1948 0.446086786479582 612 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_1327 1436-0082 2.18 µM -0.136362791413646 0.425929175429635 no 1949 0.44576724350833 611 15992205 SGTC_2266 7929956 200 µM -0.1366034365126 0.425818351765596 no 1950 0.445672130012269 606 2967153 SGTC_1985 st071382 65.5 µM -0.139323298044302 0.424566190370909 no 1951 0.444597340123013 641 6123237 SGTC_1022 4477-0945 21.3 µM -0.139579623412806 0.424448223131564 no 1952 0.444496070578726 605 4648966 SGTC_462 ag-879 158 µM -0.141313561800544 0.423650400284919 no 1953 0.443811118179171 625 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_17 0960-0276 49.807 µM -0.141655053936051 0.423493309085923 no 1954 0.443676239296975 607 6821114 SGTC_1640 st009078 66.4 µM -0.142487220720268 0.423110551596004 no 1955 0.443347586384362 619 690618 SGTC_224 benfluorex 43.875 µM -0.143373723265467 0.422702882046923 no 1956 0.442997517176606 605 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_854 0422-0053 192 µM -0.144337524515793 0.422259759622507 no 1957 0.442616974127133 609 3596728 SGTC_1344 1488-0097 29.1 µM -0.14624572513063 0.421382725822471 no 1958 0.441863705067653 600 747966 SGTC_1210 3013-0140 750 nM -0.147054342261773 0.421011192246454 no 1959 0.441544563794562 620 905973 SGTC_1730 st033808 45.1 µM -0.147200148619913 0.420944206387329 no 1960 0.44148702164702 601 1045166 SGTC_236 1509-0011 5.31 µM -0.147337680801691 0.420881023919535 no 1961 0.441432746016197 631 3107280 SGTC_2102 5377816 72.7585 µM -0.147765426165469 0.420684530160934 no 1962 0.441263947835716 614 1379702 SGTC_610 4215-0184 155 µM -0.147843179168874 0.42064881481731 no 1963 0.441233265853312 606 5605015 SGTC_1619 st003326 88.7 µM -0.147871611666753 0.42063575469478 no 1964 0.441222046241019 600 2849032 SGTC_378 3970-0959 8.33 µM -0.148893380717552 0.420166475579211 no 1965 0.440818882207902 640 6615653 SGTC_467 ro 31-8220 72.8 µM -0.151013263614387 0.419193216284946 no 1966 0.43998262651996 620 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_3302 9125395 16.351 µM -0.152072264664923 0.418707203127301 no 1967 0.439564969673424 630 17599668 SGTC_3126 9127922 49.47 µM -0.15294819713699 0.418305300342242 no 1968 0.439219563599208 625 45595682 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.154270641098819 0.417698687050984 no 1969 0.4386981725895 637 23847180 SGTC_364 0083-0097 67.7 µM -0.154381392454394 0.417647893578662 no 1970 0.438654512218203 632 5207356 SGTC_578 3460-0051 92 µM -0.154819891590852 0.417446799886952 no 1971 0.438481654533838 635 2876744 SGTC_62 0180-0423 3.232 µM -0.156077970884033 0.416869970497857 no 1972 0.437985781118198 617 30102 YGL099W LSG1 SGTC_2774 tamoxifen 10.92 µM -0.156765674768537 0.416554733802001 no 1973 0.437714762939391 614 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_497 capsazepine 133 µM -0.157192931653974 0.416358910459631 no 1974 0.437546399386582 611 2733484 A calcium channel blocker. SGTC_1498 4478-3555 97.6 µM -0.157762360453289 0.416097958175174 no 1975 0.437322029582645 626 3437919 SGTC_2947 9072639 7.68 µM -0.158097091326097 0.415944578223325 no 1976 0.437190146287043 639 16488146 SGTC_923 1900-2434 73.3 µM -0.160112890711976 0.415021172703541 no 1977 0.436396073430463 627 5910570 SGTC_1265 0819-1001 68.8 µM -0.1606193077112 0.414789264714639 no 1978 0.436196623495448 632 3106768 SGTC_1742 st038235 28.8875 µM -0.160636647918693 0.414781324486284 no 1979 0.436189794423876 614 564103 YBR002C RER2 SGTC_785 1270-0111 65.3 µM -0.161437004817265 0.414414872202839 no 1980 0.435874611631911 612 6741994 SGTC_1449 4112-4002 201 µM -0.161976407185734 0.414167942840168 no 1981 0.435662216424054 613 2059539 SGTC_552 k242-0005 476 µM -0.162262902431027 0.414036803907671 no 1982 0.435549413528064 634 4088318 SGTC_2401 5128683 200 µM -0.1624843909671 0.413935427396695 no 1983 0.435462209572095 660 708373 SGTC_1339 1486-1321 22.7 µM -0.162953383739177 0.413720785783577 no 1984 0.43527756918188 631 3469382 SGTC_1662 st014054 52 µM -0.16320321864902 0.413606455589021 no 1985 0.43517921603538 615 2838777 SGTC_664 1222-0054 14.9 µM -0.163249369677364 0.41358533661929 no 1986 0.435161048080914 608 6813991 SGTC_2068 5226020 147 µM -0.163497484630314 0.41347180210949 no 1987 0.435063376739386 648 1810509 SGTC_2600 tangeritin 87.95 µM -0.163860895210779 0.413305522725071 no 1988 0.434920326013537 646 68077 A bioactive flavone. SGTC_2416 tofa 880 nM -0.164855261292648 0.41285062769647 no 1989 0.434528953405382 624 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_3298 9116858 71.43 µM -0.165599822694942 0.412510087982124 no 1990 0.434235943417353 656 2506942 SGTC_85 0868-0259 160.055 µM -0.165937614473493 0.412355614006017 no 1991 0.434103022878957 622 83173 SGTC_1656 st012921 11 µM -0.166854768394298 0.411936263180051 no 1992 0.433742161859268 610 6732821 SGTC_1957 st077035 62.4 µM -0.166963753413776 0.41188643857024 no 1993 0.433699284559094 624 705593 SGTC_470 aa-861 153 µM -0.167767495158168 0.411519036402561 no 1994 0.433383097556577 617 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_1084 voriconazole 435 nM -0.167808803630113 0.411500155785869 no 1995 0.433366848210834 632 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_360 0957-0399 1.01 µM -0.168504059190016 0.411182410262571 no 1996 0.433093375279782 650 6752301 YPR165W RHO1 SGTC_3151 9099821 49.47 µM -0.169382410052104 0.410781069883307 no 1997 0.432747929169073 661 17174189 SGTC_472 calcifediol 10 µM -0.169482859977302 0.41073517775423 no 1998 0.432708426544915 606 5283731 A vitamin D metabolite. SGTC_1989 st071868 50.2 µM -0.169540775722712 0.410708718589869 no 1999 0.432685651085211 620 16414057 SGTC_426 0988-0037 14.6 µM -0.170451268648005 0.410292807779582 no 2000 0.432327627724206 617 5383008 SGTC_2112 5488546 200 µM -0.170888816761913 0.410092972792683 no 2001 0.432155595122835 649 600757 SGTC_3108 9121785 49.47 µM -0.170913700663001 0.410081608631559 no 2002 0.432145811802799 597 17140271 SGTC_390 dec-rvkr-cmk 16.7 µM -0.171558798011642 0.409787027259773 no 2003 0.431892200762237 633 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_348 k064-0012 10.7 µM -0.171643977545172 0.409748134135496 no 2004 0.431858715710028 616 5066323 SGTC_2000 st075254 36.4 µM -0.172315860009494 0.409441382583179 no 2005 0.431594608182027 619 17234175 SGTC_134 0269-0018 6.916 µM -0.173046610308583 0.409107817541915 no 2006 0.431307395252903 610 4378915 SGTC_148 3253-0744 288.01 µM -0.173449123160471 0.408924110893681 no 2007 0.431149207747084 610 6893655 SGTC_2976 9009005 19.48 µM -0.173651302780192 0.408831843769653 no 2008 0.431069755344259 612 2993148 SGTC_2113 5491891 107.031 µM -0.173761926734712 0.408781361323041 no 2009 0.431026283601951 646 789979 SGTC_175 3793-3120 23.7 µM -0.174412976235367 0.408484290249494 no 2010 0.430770458527888 670 5322297 SGTC_3132 9126706 49.47 µM -0.174427121572742 0.408477836376191 no 2011 0.430764900544482 628 850858 SGTC_2188 6126565 140.678 µM -0.174906661648997 0.408259058771894 no 2012 0.430576487863993 646 874518 SGTC_3041 9091929 49.47 µM -0.175019857419002 0.408207420334474 no 2013 0.430532015222917 627 25236887 SGTC_2675 theaflavin digallate 100 µM -0.177232425027861 0.407198396950084 no 2014 0.429662913657682 625 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_1646 st011709 75.6 µM -0.177265655231997 0.407183247262143 no 2015 0.429649863345165 615 5757843 SGTC_792 4534-1957 155 µM -0.177296431621751 0.407169216394826 no 2016 0.429637776774037 616 1717904 SGTC_81 0411-0046 9.971 µM -0.177744818953324 0.406964811422768 no 2017 0.42946169260555 632 12925265 SGTC_2277 7947813 106.88 µM -0.178639802471643 0.406556893818012 no 2018 0.429110269654252 661 1246798 SGTC_1724 st037281 8.293 µM -0.180294625074668 0.405802922371331 no 2019 0.428460637549789 624 574124 YDL195W SEC31 SGTC_901 1112-0062 60.1 µM -0.180745925296035 0.405597361146152 no 2020 0.428283504619187 613 1908457 SGTC_2281 7943571 200 µM -0.181256567528822 0.405364801820799 no 2021 0.428083097690249 628 1244024 SGTC_1509 1326-1131 80 µM -0.181496421884545 0.405255577636227 no 2022 0.427988970718317 595 768313 SGTC_1979 st071809 45.3 µM -0.181609044685052 0.405204294335403 no 2023 0.427944775130755 662 4976333 SGTC_3195 9113082 49.47 µM -0.184640520199585 0.403824512548207 no 2024 0.426755500909165 615 17018038 SGTC_289 k017-0060 526 µM -0.185000507422963 0.403660742792005 no 2025 0.426614318788815 630 5512909 SGTC_2540 epiandrosterone 100 µM -0.185343633052239 0.403504659637538 no 2026 0.426479758309208 633 441302 A steroid. SGTC_1583 clindamycin 39.6 µM -0.185505882252089 0.403430860046301 no 2027 0.426416133484528 648 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_827 3253-0474 693 µM -0.186824676263119 0.402831129969847 no 2028 0.425899049342813 648 5402065 SGTC_2870 9038528 12.99 µM -0.186857432395856 0.402816236810487 no 2029 0.425886207653184 652 6463316 SGTC_1063 disulfiram 1.84 µM -0.187442699311029 0.402550158567871 no 2030 0.425656773313292 607 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_2374 9071832 200 µM -0.187443678343625 0.402549713510832 no 2031 0.425656389537338 619 17381698 SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.188095674594692 0.402253351536329 no 2032 0.42540082587762 639 229346 A bile salt which induces apoptosis. SGTC_2731 amoxapine 43.43 µM -0.18851837515038 0.402061244899239 no 2033 0.425235156232809 615 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_800 3448-7362 155 µM -0.188858820902599 0.401906538172886 no 2034 0.42510173442946 630 15991913 SGTC_3141 9094609 49.47 µM -0.190735852236658 0.401053846642149 no 2035 0.42436627414473 655 25236309 YDL196W YDL196W SGTC_741 4582-0002 126 µM -0.19169125920195 0.400620008221179 no 2036 0.423992026582481 607 2912688 SGTC_2560 caryophyllene 100 µM -0.19231355435331 0.400337497610916 no 2037 0.423748300863809 622 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_1082 camptothecin 424.86 nM -0.193262468476854 0.399906808375566 no 2038 0.423376708995052 600 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1433 4060-0023 7.6 µM -0.193950849854049 0.399594444825251 no 2039 0.423107183580038 619 3840627 SGTC_3275 9138069 49.47 µM -0.194558386597453 0.39931881913079 no 2040 0.422869341558077 623 17617007 SGTC_1808 st050063 61.5 µM -0.194818017726447 0.399201045649431 no 2041 0.422767708220703 649 4011993 SGTC_2553 4-methylesculetin 85.09 µM -0.196472620305985 0.398450703283231 no 2042 0.422120130422884 637 5319502 SGTC_3171 9103192 49.47 µM -0.197695384542132 0.397896435384003 no 2043 0.42164170052465 621 13018434 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.197917740554673 0.397795665532384 no 2044 0.421554711887366 626 5711223 A potent inhibitor of glutathione S-transferases. SGTC_42 0133-0086 60.653 µM -0.198805551962045 0.397393384988451 no 2045 0.421207426423131 654 162923 Model of phenazepam hydroxylation. SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.199214722018402 0.397208020660384 no 2046 0.421047391862137 627 279621 SGTC_1966 st070145 16.1 µM -0.199388073926847 0.397129494884222 no 2047 0.42097959440945 630 3748532 SGTC_2645 abamectin 100 µM -0.199450990219493 0.397100995792448 no 2048 0.420954988600617 620 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_205 1486-1330 71.903 µM -0.199909224288189 0.396893446826995 no 2049 0.420775788061973 629 4118834 SGTC_2328 6201408 200 µM -0.200139187226255 0.396789300208287 no 2050 0.420685863170714 666 2890418 SGTC_3200 9114385 49.47 µM -0.200331497820676 0.396702211399141 no 2051 0.420610665059532 648 17018030 YLR208W SEC13 SGTC_1190 1486-1332 13 µM -0.200424524734506 0.396660085547283 no 2052 0.420574290317263 638 4150046 SGTC_920 mycophenolic acid 780.421 nM -0.200536269678463 0.396609485108958 no 2053 0.42053059747659 629 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_256 clotrimazole 625 nM -0.203191365991666 0.395407716161378 no 2054 0.419492730508514 628 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_2594 a-mangostin 100 µM -0.205533625731303 0.394348370295139 no 2055 0.418577614652407 660 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_2974 9094440 9.66 µM -0.206455909191831 0.393931458269529 no 2056 0.418217401074329 640 25236134 SGTC_1689 st020265 53.493 µM -0.206860336487354 0.393748677936946 no 2057 0.418059466690962 669 5758320 YPR016C TIF6 SGTC_1562 morin hydrate 59.1 µM -0.206908327310853 0.393726990106298 no 2058 0.418040726495278 659 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_1876 myriocin 605 nM -0.207291758860232 0.393553723020864 no 2059 0.417891004926261 648 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_542 3381-0244 89.3 µM -0.208100718946241 0.393188235018102 no 2060 0.417575162905185 636 1112843 SGTC_1929 genistein trimethyl ether 50.5 µM -0.209048031469155 0.392760359074111 no 2061 0.417205371584488 628 136420 SGTC_1710 st031758 61.5 µM -0.210117522224787 0.392277454184238 no 2062 0.416787974989932 628 5394341 SGTC_811 0416-0114 265 µM -0.212486866572347 0.391208220827249 no 2063 0.415863611405483 633 6612453 SGTC_868 0527-0199 213 µM -0.212659171610162 0.391130495280323 no 2064 0.415796407309142 625 2849450 SGTC_639 0833-0042 114 µM -0.213202823207648 0.390885286521125 no 2065 0.415584383145823 645 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_3038 9091290 49.47 µM -0.213301298385369 0.390840874888487 no 2066 0.415545980446221 653 25236843 SGTC_2323 6148992 148.28 µM -0.213480237502743 0.390760178212951 no 2067 0.415476201015524 642 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_1264 0783-0040 158 µM -0.213971464648353 0.390538672322576 no 2068 0.415284654874161 632 2855798 SGTC_710 3448-4187 58 µM -0.214636699959632 0.390238758686772 no 2069 0.415025289141987 635 3946412 SGTC_1540 guanosine 70.6 µM -0.215670663016639 0.389772738123714 no 2070 0.414622235283389 636 6802 Guanosine is a purine nucleoside SGTC_2160 5660466 132.927 µM -0.216025293149611 0.389612938173897 no 2071 0.414484015969552 715 2859134 SGTC_1462 k081-0014 26.5 µM -0.216726724491133 0.389296921048025 no 2072 0.414210659913618 663 3270634 SGTC_3256 9138902 49.47 µM -0.21737810598435 0.389003518518758 no 2073 0.413956846080927 645 17228773 SGTC_1919 st067113 52.3 µM -0.21902196747972 0.388263353798384 no 2074 0.413316467806812 654 1268243 SGTC_463 ikarugamyin 104 µM -0.219665347059243 0.387973776143965 no 2075 0.413065897259643 650 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_2147 5545932 89.7195 µM -0.220307032177038 0.387685023182193 no 2076 0.412816021907698 675 797404 SGTC_61 0978-8327 98.565 µM -0.220706697182886 0.387505208633013 no 2077 0.412660408226609 673 6150059 YHR072W ERG7 SGTC_1059 3448-6867 171 µM -0.220722113130217 0.387498273278356 no 2078 0.41265440614372 645 3934407 SGTC_2146 5545642 200 µM -0.221372322612296 0.387205788559968 no 2079 0.41240127059654 643 825326 SGTC_454 lyso-paf C-16 6.67 µM -0.222284591443328 0.386795529249029 no 2080 0.412046173160633 670 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_3246 9135460 32.98 µM -0.222627031737414 0.386641561958774 no 2081 0.411912898050807 635 41446951 SGTC_2133 5320837 200 µM -0.223717422699059 0.386151421615208 no 2082 0.411488594088957 670 2841355 SGTC_630 4356-0227 183 µM -0.225124629297623 0.385519138418828 no 2083 0.410941160654969 673 779312 SGTC_1139 k015-0024 46.9 µM -0.225891830553402 0.385174549106469 no 2084 0.410642775946172 684 2766652 SGTC_2059 5238311 157 µM -0.226240656148415 0.385017903656678 no 2085 0.410507125604438 635 703021 SGTC_200 k038-0079 37.545 µM -0.22706477758187 0.384647893938844 no 2086 0.410186686068653 644 3436683 SGTC_1907 st060210 83.7 µM -0.228658732988971 0.383932546548152 no 2087 0.409567085664912 667 688793 SGTC_1995 st072814 61.1 µM -0.23072033791093 0.383007910400693 no 2088 0.408766036195698 644 5769371 SGTC_1668 st014914 51.6 µM -0.23297182919763 0.38199887081177 no 2089 0.407891640483242 628 2839556 SGTC_1526 st051518 75 µM -0.233000206556344 0.381986158170395 no 2090 0.407880622686805 655 673993 SGTC_446 go6976 132 µM -0.233033258297093 0.381971351634697 no 2091 0.407867790106119 668 3501 A protein kinase C inhibitor. SGTC_2006 4011487 200 µM -0.23380479665334 0.381625766582614 no 2092 0.407568262792984 648 45595294 SGTC_980 1473-0395 201 µM -0.234488594924342 0.381319560637895 no 2093 0.40730284316922 635 768876 SGTC_1188 1403-0014 4.57 µM -0.234790172975962 0.381184537102825 no 2094 0.407185797697871 640 9614867 SGTC_73 0327-0325 16.231 µM -0.235049486138571 0.38106844810939 no 2095 0.407085162280774 662 53298 SGTC_292 k038-0015 474 µM -0.235518549336369 0.380858485678461 no 2096 0.406903141714335 669 46368540 SGTC_3247 9135149 49.47 µM -0.235885891969113 0.380694079974832 no 2097 0.406760607979154 649 8934436 YOR116C RPO31 SGTC_2621 lithochol-11-enic acid 100 µM -0.235952842538682 0.38066411829251 no 2098 0.406734631614517 682 6708711 SGTC_448 monastrol 171 µM -0.236440390506842 0.380445952686249 no 2099 0.406545478707759 652 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_2766 oltipraz 83.91 µM -0.236502733628477 0.380418058428056 no 2100 0.406521293156142 656 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_1413 3910-0535 34.4 µM -0.236976513314457 0.380206094938889 no 2101 0.406337505499824 652 2876951 SGTC_698 k064-0052 127 µM -0.238216493623951 0.379651512671074 no 2102 0.405856592617366 653 5088751 SGTC_2105 5350118 200 µM -0.238364926285423 0.379585142597514 no 2103 0.405799034128298 654 2133313 SGTC_1931 st074438 57.1 µM -0.23849432845774 0.37952728469774 no 2104 0.405748856850432 680 2787313 SGTC_1318 1280-3875 124 µM -0.238813356360653 0.379384653452656 no 2105 0.405625156488726 680 373245 SGTC_2732 terfenadine 20 µM -0.240705281172431 0.378539148139085 no 2106 0.404891772759853 652 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_141 0443-0274 32.331 µM -0.242195390400758 0.377873623936479 no 2107 0.404314383335431 659 1627241 SGTC_1205 4161-2785 76 µM -0.242944987734215 0.377538969778669 no 2108 0.404024007092917 696 3498106 SGTC_2598 perillyl alcohol 100 µM -0.242983120158047 0.377521948194542 no 2109 0.404009236907643 645 10819 An apoptosis inducer. SGTC_2714 st079313 56.9 µM -0.243452577276136 0.37731241102431 no 2110 0.403827408949263 640 2939799 SGTC_2982 9019404 25.97 µM -0.244777209735845 0.376721370370313 no 2111 0.403314470596207 642 22333232 SGTC_2664 lyso-paf C-16 73.48 µM -0.245118235288004 0.376569254129489 no 2112 0.403182441915594 654 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2293 7624732 200 µM -0.247326261567094 0.375584817102407 no 2113 0.402327868096686 648 894453 SGTC_1290 0986-0249 10.2 µM -0.247347142911286 0.375575511117577 no 2114 0.40231978859755 667 53329 SGTC_203 k066-0004 30.888 µM -0.248581285197646 0.375025631717043 no 2115 0.401842343208776 653 6795412 SGTC_2151 5563267 85.4165 µM -0.248798249564014 0.374928988171914 no 2116 0.401758422593604 674 5310824 SGTC_1419 3993-2473 62.6 µM -0.248889823354715 0.374888200347273 no 2117 0.401723003717821 653 704026 SGTC_1051 3253-3903 78 µM -0.249572952404347 0.374583972450946 no 2118 0.401458808816533 628 5509239 SGTC_1782 st039423 80.636 µM -0.251177116846505 0.373869873475925 no 2119 0.400838587832414 683 2068169 SGTC_3266 9136860 49.47 µM -0.25200881920536 0.373499808656367 no 2120 0.400517123510377 669 4871271 YPR165W RHO1 SGTC_1903 st060211 78.3 µM -0.25287581086229 0.373114166063096 no 2121 0.400182091114896 643 688960 SGTC_1629 st005085 44.9 µM -0.252877463961065 0.373113430877064 no 2122 0.400181452376471 672 24207091 SGTC_233 rapamycin 362 pM -0.253074778287989 0.373025682188397 no 2123 0.400105214299805 650 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_1692 fluoroquinolonic acid 71 µM -0.253977766159747 0.372624193825999 no 2124 0.399756367529605 697 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_2471 5466956 24.79 µM -0.253989504915987 0.37261897542564 no 2125 0.399751833080998 654 724419 SGTC_1614 st002383 48.6 µM -0.255540714279858 0.371929599754807 no 2126 0.399152750841736 662 1947235 SGTC_653 0203-0016 55.2 µM -0.255786868471702 0.371820243609899 no 2127 0.399057707063117 679 295302 SGTC_2061 5245884 80.95 µM -0.258091986400845 0.370796677820429 no 2128 0.398167958026381 671 573863 SGTC_2081 5214970 32.255 µM -0.259362493463912 0.370232911273929 no 2129 0.397677782828584 663 2063512 SGTC_278 4092-0821 23.9 µM -0.259964394191691 0.369965924958444 no 2130 0.397445619429913 690 877900 SGTC_1669 st015249 58.4 µM -0.260519244341341 0.3697198644597 no 2131 0.397231636417794 667 722793 SGTC_705 1124-0212 310 µM -0.261540450870818 0.36926712745683 no 2132 0.396837879714236 653 9554485 SGTC_1281 0884-0031 11.8 µM -0.262867039566714 0.368679274474335 no 2133 0.396326530867226 649 1548255 SGTC_2434 5670830 169.91 µM -0.264105856748939 0.368130593094412 no 2134 0.39584917552244 674 1549830 SGTC_703 3875-0075 71.8 µM -0.264147556235999 0.368112128751873 no 2135 0.395833110107257 674 2850814 SGTC_2520 obtusaquinone 4.71 µM -0.264245248295968 0.368068872346692 no 2136 0.395795473322763 638 5967872 SGTC_624 k048-0052 28 µM -0.26442183669631 0.36799068621055 no 2137 0.395727443447042 650 6835531 SGTC_2526 patulin 37.61 µM -0.264531128355499 0.36794229906404 no 2138 0.395685340925099 667 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_988 1497-1057 103 µM -0.264984643896107 0.367741534656211 no 2139 0.395510645745062 684 3533044 SGTC_145 3737-0113 38.366 µM -0.265422125190818 0.367547902601339 no 2140 0.395342146883792 665 6849351 SGTC_2700 st077718 96.8 µM -0.265630041020112 0.367455889508024 no 2141 0.395262073561332 655 904970 SGTC_3168 9103419 49.47 µM -0.265741330037223 0.367406641710119 no 2142 0.395219215335284 667 16649256 SGTC_3243 9134147 49.47 µM -0.266607929808345 0.36702322722756 no 2143 0.394885524735363 679 24282180 SGTC_2092 5303694 80.6725 µM -0.266888175330113 0.366899265020691 no 2144 0.394777630625234 681 1963699 SGTC_1018 4259-0013 28.1 µM -0.267327409267463 0.366705004708877 no 2145 0.394608542449119 674 6801262 SGTC_2718 lomofungin 53.02 µM -0.268778636229871 0.366063412468447 no 2146 0.394050017196578 680 5351222 A RNA synthesis inhibitor. SGTC_2451 5856223 45.7 µM -0.269728558247578 0.365643651378308 no 2147 0.393684544133841 645 2179896 SGTC_2674 ligustilide 100 µM -0.270512616085737 0.365297305153713 no 2148 0.393382956187979 646 5319022 A signalling regulator. SGTC_3274 9138298 49.47 µM -0.270753076655963 0.365191107164013 no 2149 0.393290475807162 668 17015756 SGTC_2193 5925765 200 µM -0.270867874913149 0.365140410837328 no 2150 0.393246326880665 676 877370 SGTC_293 4049-0273 38.5 µM -0.27259557953437 0.364377720273212 no 2151 0.39258205515991 658 1380311 SGTC_590 k048-0076 22.4 µM -0.272633528225342 0.364360973938009 no 2152 0.392567468066438 682 6832814 SGTC_1329 1447-1697 50.6 µM -0.273501250377226 0.363978128507872 no 2153 0.392233965653637 665 2840515 SGTC_2728 chlorpromazine 9.18 µM -0.273592205813689 0.363938006149402 no 2154 0.392199012201492 675 2726 A thorazine and dopamine antagonist. SGTC_1247 0448-0043 5.84 µM -0.27371051521535 0.363885819612843 no 2155 0.392153548139226 696 3089013 YGL099W LSG1 SGTC_406 estrone 100 µM -0.27526012894321 0.363202515017063 no 2156 0.391558197078676 687 5870 A steroid. SGTC_87 0100-0052 35.5 µM -0.276023200588264 0.36286619713823 no 2157 0.391265123351272 669 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_3046 9092212 49.47 µM -0.27642430375116 0.362689456430491 no 2158 0.391111095977517 647 25236637 SGTC_2878 9043973 25.97 µM -0.276828009148575 0.362511598619381 no 2159 0.390956086564698 661 6465167 SGTC_2824 7998404 51.95 µM -0.278052003572951 0.361972532981382 no 2160 0.390486219488349 654 837851 SGTC_1072 oxiconazole 14.9 nM -0.278244265955628 0.361887882569505 no 2161 0.390412428302724 664 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2136 5328288 199.296 µM -0.278504663653615 0.361773243913687 no 2162 0.390312492764251 664 262395 SGTC_2724 maprotiline 69.64 µM -0.279060594611678 0.361528539882591 no 2163 0.390099161606806 652 4011 A tricyclic antidepressant. SGTC_2712 st079126 47.7 µM -0.281401385253052 0.360498816712044 no 2164 0.389201277875488 683 3152970 SGTC_64 000l-0018 272.079 µM -0.281995806818762 0.360237488933873 no 2165 0.388973362778503 679 6811119 SGTC_1990 st072050 59.8 µM -0.282539455162435 0.359998539934732 no 2166 0.388764948763425 663 17233948 SGTC_2285 7945142 200 µM -0.285127070442146 0.358861960175719 no 2167 0.387773395626612 706 2970608 SGTC_2705 st078069 42.8 µM -0.285468298948345 0.358712172503393 no 2168 0.387642694082216 689 1530061 SGTC_2261 9010538 184.68 µM -0.286394695199751 0.358305625782523 no 2169 0.387287918621671 738 6457250 SGTC_2179 6298986 200 µM -0.286877257851617 0.358093917923672 no 2170 0.387103152258134 678 738374 SGTC_2222 6885208 172.143 µM -0.287741135139417 0.357715030304978 no 2171 0.386772449856651 646 609514 SGTC_1608 st001473 40.5 µM -0.288578497041912 0.357347905820539 no 2172 0.386451976302771 699 7292267 SGTC_45 0kpi-0036 14.9 µM -0.289686945542319 0.356862131919096 no 2173 0.386027872126509 684 2795021 SGTC_2205 7238770 200 µM -0.289763529222576 0.356828577933519 no 2174 0.385998575419745 675 279867 SGTC_3257 9139206 32.98 µM -0.289825040350266 0.356801628561848 no 2175 0.385975045113932 690 4910041 SGTC_3017 9080681 49.47 µM -0.290423570896435 0.356539436555836 no 2176 0.385746106716998 689 16451914 SGTC_2440 5628896 157.78 µM -0.290684135378567 0.356425314972858 no 2177 0.385646453028934 669 5522048 SGTC_1974 st069448 26.9 µM -0.290720533607006 0.356409374362541 no 2178 0.385632533015119 662 6323587 YNR016C ACC1 SGTC_353 1988-1175 58.3 µM -0.291519421178351 0.356059564638959 no 2179 0.385327046314044 696 2788357 SGTC_332 4112-0506 40.9 µM -0.294582767871341 0.354719338848466 no 2180 0.384156313784866 669 2790355 SGTC_3203 9113543 49.47 µM -0.294786487508856 0.354630274254768 no 2181 0.384078494702713 667 17018012 SGTC_1752 st044819 83.042 µM -0.295409408234966 0.35435798762038 no 2182 0.383840573552323 668 441209 YML126C ERG13 SGTC_795 0685-0265 78 µM -0.295888326297275 0.354148696995247 no 2183 0.383657683191045 669 302754 SGTC_3255 9139072 49.47 µM -0.296545597123579 0.353861536655081 no 2184 0.383406725250808 675 17646060 SGTC_1470 k295-0292 231 µM -0.298241336577951 0.353121055582778 no 2185 0.382759487235933 668 5045612 SGTC_2119 5528445 120.635 µM -0.299423045510878 0.352605365415851 no 2186 0.382308640255418 687 791935 SGTC_228 caffeine 993.056 µM -0.29971108040943 0.352479709846492 no 2187 0.382198772996569 676 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_1942 st076330 65.2 µM -0.300459867563592 0.352153125901393 no 2188 0.381913202029472 718 24208414 SGTC_1817 st052116 64.4 µM -0.300495138101864 0.352137745322419 no 2189 0.381899752204302 679 4361398 SGTC_536 3852-0578 10.6 µM -0.301606003066796 0.351653449435834 no 2190 0.381476215603233 681 2869208 SGTC_1391 3442-0225 151 µM -0.301765143396563 0.351584089849011 no 2191 0.381415552190335 656 5227075 SGTC_1493 4348-0038 111 µM -0.302263330185676 0.351366992491496 no 2192 0.381225664984377 688 800424 SGTC_2216 7189485 200 µM -0.302759705115064 0.351150732914154 no 2193 0.381036496816701 676 731273 SGTC_266 formosanin C 406 nM -0.303600194188148 0.350784660335562 no 2194 0.38071625180916 682 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_2775 cyproheptadine 69.59 µM -0.303738089470174 0.350724613660555 no 2195 0.380663718440384 684 2913 A selective serotonin reuptake inhibitor. SGTC_2534 helenine 20.12 µM -0.303818787395249 0.350689475376472 no 2196 0.380632976321649 651 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.304896114425166 0.350220497500886 no 2197 0.380222637597957 675 6857784 SGTC_2614 arthonioic acid 13.39 µM -0.306758646885641 0.349410245864549 no 2198 0.379513543298654 691 6710684 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.307189380830949 0.349222962524569 no 2199 0.379349613948964 672 66535 A nucleotide analog. SGTC_953 1188-0045 9.7 µM -0.307772583978058 0.348969444005692 no 2200 0.379127692218628 688 6144426 SGTC_1917 st066507 28.5 µM -0.30899201804285 0.34843957369922 no 2201 0.378663799304199 672 3156428 SGTC_736 0958-0254 92.6 µM -0.309703341520713 0.34813062480297 no 2202 0.378393280735326 725 6812352 SGTC_3198 9112019 49.47 µM -0.310004692501866 0.34799976950388 no 2203 0.378278693966399 725 45595555 SGTC_1212 0520-0165 585 µM -0.310800689087192 0.347654211874089 no 2204 0.377976072897927 762 5403258 SGTC_2054 5233173 129 µM -0.310862904676423 0.347627208202371 no 2205 0.377952422998492 660 6889 SGTC_2459 5811157 9.22 µM -0.311511425375458 0.347345774319495 no 2206 0.377705929246393 677 2870684 YBR192W RIM2 SGTC_169 k015-0017 16.025 µM -0.312264278006939 0.347019169797084 no 2207 0.377419842827374 739 1840002 SGTC_2913 7966556 36.57 µM -0.312944976073239 0.346723965348394 no 2208 0.37716123325995 695 2976516 SGTC_383 2324-0395 7.37 µM -0.313987130893773 0.346272185004813 no 2209 0.376765406463019 703 3146421 SGTC_474 dl-dihydrosphingosine 5 µM -0.314587904952996 0.346011845171238 no 2210 0.376537281844123 674 3058739 A sphingolipid protein kinase C inhibitor. SGTC_1704 st028805 70.8 µM -0.315516106118111 0.345609760958087 no 2211 0.376184912100118 688 2876101 SGTC_832 4083-0019 164 µM -0.315986374074731 0.345406113652137 no 2212 0.376006425293068 672 1990758 SGTC_2948 9070189 9.45 µM -0.316490096519328 0.345188028670444 no 2213 0.375815270495598 703 6473636 YDL196W YDL196W SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.316923116288295 0.34500059526182 no 2214 0.375650970613857 700 1377 SGTC_1839 st053978 48 µM -0.318592158391824 0.344278503390829 no 2215 0.375017900263139 682 3788398 SGTC_2868 9035608 32.47 µM -0.318993728044267 0.344104853466861 no 2216 0.374865634415717 659 6462614 SGTC_1303 1160-0052 261 µM -0.319617175702814 0.343835322439582 no 2217 0.374629276256062 686 3562476 SGTC_1286 0929-0070 131 µM -0.319773000957818 0.343767967921027 no 2218 0.374570207967355 689 1420408 SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.320042828447574 0.343651348358387 no 2219 0.374467932098906 659 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_2191 5911152 200 µM -0.320907461826978 0.343277753693142 no 2220 0.374140259525572 684 2875902 SGTC_3154 9100113 49.47 µM -0.321036560695472 0.343221985203308 no 2221 0.374091342354407 692 25237525 SGTC_197 4544-0043 41.561 µM -0.321226243242847 0.343140051800164 no 2222 0.374019472949716 686 896523 SGTC_1409 3909-8004 61.9 µM -0.321650183596838 0.342956957365909 no 2223 0.373858860716857 666 2119279 SGTC_1769 st044406 64.4 µM -0.322882651052149 0.342424879926296 no 2224 0.373392057828318 707 670903 SGTC_843 0310-0051 143 µM -0.323663790996553 0.342087810116897 no 2225 0.373096293491958 699 2065037 SGTC_416 estradiol valerate 100 µM -0.324456677868926 0.341745800032481 no 2226 0.372796157859929 699 13791 A steroid. SGTC_6 0844-0013 19.835 µM -0.32449615695044 0.341728774205351 no 2227 0.372781215652171 691 1584900 SGTC_2622 2-methoxyxanthone 59.94 µM -0.32455850050085 0.341701888457591 no 2228 0.372757619994498 671 71034 A hepatoprotective. SGTC_1686 st019653 115.5 µM -0.325635673732904 0.341237482815653 no 2229 0.372350009162281 714 97252 SGTC_3049 9092223 49.47 µM -0.325743522332769 0.341190998879458 no 2230 0.372309206268711 712 8623917 SGTC_1670 st016595 4.04 µM -0.326973900565112 0.34066086300942 no 2231 0.371843812755241 696 597879 SGTC_557 1315-0110 16.2 µM -0.327197245540995 0.340564663557658 no 2232 0.371759352038801 671 6833801 SGTC_1187 1391-0724 117 µM -0.327224649772168 0.340552860684142 no 2233 0.371748989208563 684 6997986 SGTC_177 1327-0068 8.361 µM -0.32744066165432 0.340459830849198 no 2234 0.371667308197882 668 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_3286 9117135 37.221 µM -0.327539360080725 0.340417327629431 no 2235 0.371629989084597 676 3438150 SGTC_2755 lomerizine 42.69 µM -0.329820576744787 0.339435516537815 no 2236 0.370767769293028 686 3949 A calcium channel blocker. SGTC_984 1492-0255 2.91 µM -0.330327906055288 0.339217315235486 no 2237 0.370576104634433 712 1585198 SGTC_395 anisomycin 6.25 µM -0.330442002354166 0.339168250072749 no 2238 0.370533004454316 709 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2876 9059903 25.97 µM -0.33083954621932 0.338997314441033 no 2239 0.37038284390046 677 6916095 SGTC_1285 0929-0069 65.5 µM -0.332267551636064 0.338383575225339 no 2240 0.369843619695337 682 1206237 SGTC_1963 st076565 50.3 µM -0.332503805238322 0.338282077649045 no 2241 0.369754433420427 688 4914280 SGTC_3239 9133757 49.47 µM -0.333962193655272 0.337655795671784 no 2242 0.369204043731266 704 17036923 SGTC_1464 k208-0027 110 µM -0.334891703038703 0.337256866801865 no 2243 0.368853390550787 688 X1464 SGTC_1973 st070275 50.2 µM -0.335989549784959 0.336785926136479 no 2244 0.368439373461157 683 17118334 SGTC_1753 st043925 64 µM -0.336120854381574 0.336729617833435 no 2245 0.368389866429859 712 670181 SGTC_1883 5-benzylidenerhodanine 20 µM -0.336473028913615 0.336578610348495 no 2246 0.36825709347965 682 1273210 SGTC_1760 st045453 10.4495 µM -0.336506700041703 0.336564174022187 no 2247 0.368244399986787 714 3323419 YIL048W NEO1 SGTC_1806 st050005 60.3 µM -0.337508132795655 0.336134924982501 no 2248 0.367866941181406 689 5194765 SGTC_985 1493-0307 8.71 µM -0.338321210914446 0.33578656838221 no 2249 0.367560570584037 705 3278274 SGTC_129 0088-0017 176.636 µM -0.338321534811093 0.335786429639455 no 2250 0.367560448555459 722 182446 SGTC_468 gf-109203x 121 µM -0.338470811034205 0.335722488802421 no 2251 0.367504209923782 694 2396 A protein kinase C inhibitor. SGTC_1246 0422-0085 105 µM -0.339126953217058 0.335441493891621 no 2252 0.367257047274937 716 264295 SGTC_1331 1472-0049 76.2 µM -0.339171488515836 0.335422424846051 no 2253 0.367240273234564 689 24051409 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.339734176760972 0.335181530519934 no 2254 0.36702836081407 680 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_772 k072-0172 35.3 µM -0.339837324708458 0.335137378858196 no 2255 0.366989518950258 680 5861980 SGTC_1970 st070122 35.8 µM -0.340009137611789 0.335063840763187 no 2256 0.366924823318908 728 102928 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.343793501287253 0.333445692813425 no 2257 0.365500793947147 686 4330530 SGTC_1552 6-methylflavone 10.6 µM -0.344164905830444 0.333287051005243 no 2258 0.365361136516934 692 689013 SGTC_2757 clomiphene 4.22 µM -0.344581693859887 0.333109059593678 no 2259 0.365204435013216 712 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_2552 juarezic acid 87.02 µM -0.346729445246153 0.332192448263573 no 2260 0.364397293412745 688 1549512 SGTC_672 1441-0018 53.7 µM -0.348961044429366 0.331241114967129 no 2261 0.363559277694482 691 251141 SGTC_891 0929-0073 133 µM -0.34966339893596 0.330941925270827 no 2262 0.363295662562427 723 5603632 SGTC_1658 st012944 20 µM -0.350106223879676 0.330753345711348 no 2263 0.363129490079941 717 24207260 SGTC_1954 st077032 68.9 µM -0.350365697703499 0.330642867236794 no 2264 0.363032133075909 746 698907 SGTC_168 3970-0862 530.542 µM -0.350615690917646 0.330536439359922 no 2265 0.362938341656417 687 3135186 SGTC_2962 9082311 13.18 µM -0.350714372079045 0.330494432285076 no 2266 0.36290132112932 689 16459453 SGTC_2601 securinine 100 µM -0.350881439170814 0.330423319224393 no 2267 0.36283864834075 691 442872 A GABA receptor antagonist. SGTC_2101 5377231 179.231 µM -0.351952149245088 0.329967710834752 no 2268 0.362437074322185 726 2844213 SGTC_2725 haloperidol 53.21 µM -0.351966476275237 0.329961616106796 no 2269 0.362431701938168 693 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_90 0870-0863 4.608 µM -0.351997620699075 0.329948367404312 no 2270 0.362420023421115 719 1738164 SGTC_2367 9070478 135.38 µM -0.352549925707004 0.329713454699293 no 2271 0.362212941701876 669 572802 SGTC_995 3931-2021 34.6 µM -0.352719382058141 0.329641393039108 no 2272 0.362149413670694 706 730143 SGTC_368 fentichlor 4.58 µM -0.353281966266354 0.329402198317447 no 2273 0.361938531922002 743 7329 A pesticide. SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.35407068373668 0.32906697572487 no 2274 0.361642955878064 686 1241132 A phosphatase inhibitor. SGTC_79 0052-0007 94.094 µM -0.35460266986017 0.328840947286258 no 2275 0.361443637861658 692 2801472 SGTC_849 0386-0493 241 µM -0.355347015099183 0.32852479749192 no 2276 0.361164818858986 699 726119 SGTC_1437 4092-1038 11.6 µM -0.355665575559694 0.328389531063583 no 2277 0.361045514080102 700 3977136 SGTC_1581 himbacine 57.9 µM -0.356475482765126 0.328045731397949 no 2278 0.360742254841709 733 5281825 An alkaloid muscarinic receptor antagonist. SGTC_187 1488-2104 32.728 µM -0.357602566666262 0.327567534949368 no 2279 0.360320378624975 678 2852859 SGTC_3292 9120825 59.784 µM -0.358783009194889 0.327067002731168 no 2280 0.359878712134451 724 24824900 SGTC_2987 9018338 71.43 µM -0.359230294783183 0.326877425496609 no 2281 0.359711407574787 705 5055682 SGTC_2858 9025781 8.96 µM -0.359807460750587 0.326632865868984 no 2282 0.359495561743975 702 4894980 YPL153C RAD53 SGTC_1785 bathophenanthroline 24 µM -0.360754434759339 0.326231770727313 no 2283 0.359141513955204 703 72812 An iron chelator. SGTC_1719 st032227 49.2 µM -0.36204078880833 0.325687251482056 no 2284 0.358660774972594 682 3125804 SGTC_1009 4106-0057 9.87 µM -0.362730962291551 0.325395251193259 no 2285 0.358402934085212 732 2928005 SGTC_21 0849-0113 22.993 µM -0.364498019216871 0.32464812911482 no 2286 0.357743076327911 702 1560156 SGTC_1503 4585-0012 61.3 µM -0.364745408154794 0.324543587807619 no 2287 0.357650729744196 714 2922052 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.36500413899942 0.324434268440211 no 2288 0.357554158310931 690 688662 SGTC_144 4161-2749 112.381 µM -0.367049797890195 0.32357046669058 no 2289 0.356790936530872 694 797501 YMR168C CEP3 SGTC_823 0417-1665 178 µM -0.36719757234737 0.323508104046654 no 2290 0.356735825012493 738 3429856 SGTC_2799 7812892 81.82 µM -0.367546281817644 0.323360964000856 no 2291 0.356605787949714 718 20205235 SGTC_1227 3909-8010 46.6 µM -0.367609838424493 0.323334148886048 no 2292 0.356582088884457 699 15982272 SGTC_818 4072-2707 53.5 µM -0.368478801491104 0.322967617503118 no 2293 0.356258124445907 688 882871 SGTC_690 glyoxal 20.3 µM -0.368745389649161 0.322855204204748 no 2294 0.356158756556815 708 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_338 4055-0136 114 µM -0.368781625692241 0.322839925656197 no 2295 0.356145250712647 698 2900563 SGTC_2855 9016525 58.44 µM -0.369697603225321 0.322453812680071 no 2296 0.355803908910593 699 43811474 SGTC_2690 usnic acid 100 µM -0.371158666822532 0.321838325317902 no 2297 0.355259678433006 746 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2450 5739737 12.93 µM -0.372447906746419 0.32129562597767 no 2298 0.354779695434979 700 2262825 SGTC_2408 sulbentine 18.36 µM -0.372526386946368 0.321262602417203 no 2299 0.35475048475216 700 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_1708 st033234 31.827 µM -0.372690243499383 0.321193658030338 no 2300 0.354689499360417 698 674664 SGTC_186 3455-3465 67.277 µM -0.372949497309535 0.321084586821904 no 2301 0.354593015892154 717 755278 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.37432596583568 0.320505748590015 no 2302 0.354080908025027 749 6708760 SGTC_2319 6033012 152.6 µM -0.375479652467678 0.320020931528955 no 2303 0.353651888160646 689 847246 SGTC_2333 9017922 200 µM -0.376999318310616 0.319382786859909 no 2304 0.353087055755825 693 3163164 SGTC_2170 morpholine 200 µM -0.377671695612787 0.319100609750094 no 2305 0.35283724839784 713 121171 Reacts with secondary amines. SGTC_3138 9097216 49.47 µM -0.3779814226523 0.318970661602367 no 2306 0.352722197295151 723 25237486 SGTC_708 3448-5400 146 µM -0.378246676165371 0.318859390318312 no 2307 0.352623677019725 722 3462195 SGTC_8 0354-0001 70 µM -0.379479677527121 0.318342372621152 no 2308 0.352165846364766 716 4993152 SGTC_2785 7756463 72.73 µM -0.381174279810657 0.317632375191988 no 2309 0.351536966395636 707 2201551 SGTC_1529 apigenin 74 µM -0.383607789816269 0.316613965883557 no 2310 0.350634582760955 748 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_95 0471-0001 561.058 µM -0.383963611463101 0.316465172846455 no 2311 0.350502708969013 691 4015405 SGTC_2963 9082507 9 µM -0.385225062087858 0.315937914662972 no 2312 0.350035338314518 742 16459611 SGTC_605 1315-0399 119 µM -0.385236663983212 0.315933067065063 no 2313 0.350031040835675 708 24020461 SGTC_2154 5570129 200 µM -0.385793327258706 0.315700514711849 no 2314 0.349824868773245 742 673366 SGTC_1937 st074714 47.2 µM -0.386145475125947 0.31555343863766 no 2315 0.349694466192817 722 17250970 SGTC_1697 st025554 27.742 µM -0.38648746567918 0.315410632768695 no 2316 0.349567841901031 693 1269519 SGTC_3343 9148379 18.9835 µM -0.387167731980467 0.315126654205927 no 2317 0.349316018514215 728 1955036 SGTC_1831 st055328 12 µM -0.388718727248772 0.314479596650773 no 2318 0.348742113719682 726 1103068 SGTC_2067 5224629 34.075 µM -0.388734530413331 0.314473006678114 no 2319 0.348736267954613 719 2835000 SGTC_614 0462-0418 107 µM -0.389415677781466 0.31418902214738 no 2320 0.348484338170446 706 5188303 SGTC_425 3825-7017 13.1 µM -0.390245412235908 0.313843237135319 no 2321 0.348177542109347 731 3397440 SGTC_2684 capsaicin 100 µM -0.392004405137152 0.313110732050573 no 2322 0.347527479474498 738 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_2528 xanthyletin 44.79 µM -0.392417002841329 0.312939018787337 no 2323 0.347375062521232 717 65188 An natural product with antifungal activity of unknown mechanism. SGTC_1784 st039334 36.3 µM -0.393647041172515 0.312427347236687 no 2324 0.34692082286325 709 3496984 SGTC_2485 5633444 17.78 µM -0.39430401533506 0.312154207021962 no 2325 0.346678299564164 699 5724239 SGTC_1229 0139-0193 12.2 µM -0.394990339640244 0.311868974582942 no 2326 0.34642500869294 711 3090752 SGTC_2624 nerol 100 µM -0.395370999569481 0.311710823120049 no 2327 0.346284554138116 751 637566 A natural product oil. SGTC_2318 6029776 164 µM -0.396044396478049 0.311431134290492 no 2328 0.346036138308173 759 818325 SGTC_626 0214-0009 33 µM -0.397601948687099 0.310784637223946 no 2329 0.3454618119301 729 3437874 SGTC_2925 9010536 32.5 µM -0.398076052186169 0.310587965695401 no 2330 0.34528706318952 717 2994177 SGTC_1097 itavastatin 7.23 µM -0.399831914152233 0.309860056292634 no 2331 0.344640161469107 697 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_1804 st050076 49.1 µM -0.400234038661795 0.309693456442155 no 2332 0.344492072973854 720 3895976 SGTC_2917 7979103 53.79 µM -0.400473670484276 0.309594195761365 no 2333 0.344403836224745 733 2980565 SGTC_1465 k213-0056 144 µM -0.401418845145858 0.30920281944222 no 2334 0.344055888510447 732 24048857 YMR208W ERG12 SGTC_1407 3909-7909 12.3 µM -0.40166293974895 0.309101780307052 no 2335 0.343966051252514 706 4411780 SGTC_2007 4011539 71.82 µM -0.40236162792803 0.308812649120147 no 2336 0.34370895280944 721 45595301 SGTC_2835 9006588 71.43 µM -0.404046890806983 0.308115741202666 no 2337 0.343089119012794 706 2345538 SGTC_2841 9004761 38.96 µM -0.404752961117192 0.307823964786244 no 2338 0.342829554150756 701 2991039 SGTC_888 0916-0002 6.97 µM -0.405181093636373 0.307647102499376 no 2339 0.342672200616291 714 2802138 YIL048W NEO1 SGTC_1401 3807-4679 7.6 µM -0.405210818157115 0.307634824907114 no 2340 0.342661276838033 722 3291456 SGTC_2213 7173844 200 µM -0.405504385241905 0.307513579791335 no 2341 0.342553397835452 717 892728 SGTC_3170 9103054 49.47 µM -0.406356009725783 0.307161972347596 no 2342 0.342240518545206 746 16432970 SGTC_1354 1498-1681 81 µM -0.406425093120845 0.307133457876904 no 2343 0.342215142662445 733 5754243 SGTC_2565 isoliquiritigenin 100 µM -0.406772836931977 0.306989942824863 no 2344 0.342087419371145 687 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_2190 6049624 200 µM -0.407957915411146 0.30650107909779 no 2345 0.341652286070826 743 2265554 SGTC_276 colchicine 750 µM -0.408496331726469 0.306279087440384 no 2346 0.341454661554965 761 2833 A microtubule depolymerizer. SGTC_1833 st055984 71 µM -0.409211824665709 0.305984196254396 no 2347 0.341192108716528 701 676288 SGTC_2589 lobaric acid 100 µM -0.41188788107462 0.304882372247609 no 2348 0.340210801940399 721 73157 A novel microtubule depolymerizer. SGTC_3334 9142812 21.919 µM -0.413054284590561 0.304402676299385 no 2349 0.33978342106382 709 45283678 SGTC_3051 9093778 49.47 µM -0.41313830198088 0.304368136222066 no 2350 0.339752644268793 737 17217378 SGTC_993 3909-8757 62.7 µM -0.413438849256704 0.304244593634769 no 2351 0.339642558166714 699 4288324 YLR208W SEC13 SGTC_693 4161-2696 114 µM -0.415035479292476 0.303588659741124 no 2352 0.339057965315532 725 805759 SGTC_11 0438-0307 1.3 µM -0.415696861172852 0.303317133285939 no 2353 0.338815919185409 731 4011476 SGTC_1648 st011736 69.8 µM -0.416384857254397 0.303034795767696 no 2354 0.338564203656911 716 2855514 SGTC_3106 9121286 49.47 µM -0.4164889778644 0.30299207734821 no 2355 0.338526115570065 711 15943471 SGTC_994 3910-0338 138 µM -0.416755125232173 0.30288289512746 no 2356 0.338428764408169 729 3479481 SGTC_173 1273-0061 2.693 µM -0.417382287230303 0.302625682761812 no 2357 0.338199404326446 728 2847414 YPL266W DIM1 SGTC_1150 3909-7983 10.9 µM -0.417691431124017 0.302498932354743 no 2358 0.338086369067843 715 23965914 SGTC_499 genistein 192 µM -0.41808825403219 0.302336268044061 no 2359 0.337941296279194 744 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_3025 9087895 49.47 µM -0.418243165973847 0.302272777712979 no 2360 0.33788466921581 717 17173641 SGTC_2635 hydroquinidine 100 µM -0.418484437642622 0.302173904947255 no 2361 0.337796481217126 731 442912 An experimental heart treatment. SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.419271986189194 0.301851269817627 no 2362 0.33750868375319 681 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_2513 baicalein 25.65 µM -0.419648711825658 0.301696991328586 no 2363 0.337371048769173 740 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_1467 k284-1082 293 µM -0.419825574325274 0.301624573982103 no 2364 0.33730644036981 749 3334705 SGTC_522 1273-0010 11.6 µM -0.419934291745576 0.301580062902493 no 2365 0.33726672795204 739 5705015 SGTC_2003 4023581 200 µM -0.420269335633194 0.30144290784302 no 2366 0.337144354160338 718 16641307 SGTC_2877 9040724 71.43 µM -0.421113224948469 0.30109757402457 no 2367 0.336836202455873 730 6463895 SGTC_3229 9132204 49.47 µM -0.423788409098784 0.30000402362673 no 2368 0.335860066014025 719 17682924 SGTC_2086 5274770 176.623 µM -0.425173695461994 0.299438459279609 no 2369 0.335355029123546 729 689278 SGTC_2904 7225135 42.03 µM -0.425350310771033 0.299366388136192 no 2370 0.335290661449444 756 4446116 SGTC_871 0574-0004 149 µM -0.425779115046845 0.299191439366244 no 2371 0.335134403310052 732 9551173 SGTC_579 4491-1009 110 µM -0.426504095008313 0.298895758831744 no 2372 0.334870282363208 758 1271041 SGTC_1178 0988-0033 191 µM -0.426741020631421 0.298799158335748 no 2373 0.334783984544093 708 5392207 SGTC_2596 sinensetin 100 µM -0.427183224454144 0.298618898753239 no 2374 0.33462293950911 709 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_2812 7970281 58.44 µM -0.42883616704385 0.29794553301202 no 2375 0.334021228312572 745 2233435 SGTC_2606 farnesol 9.78 µM -0.428924101008332 0.297909730404721 no 2376 0.333989230149056 734 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_989 1501-0895 10.3 µM -0.429367204894919 0.297729349029993 no 2377 0.33382800808187 757 2830112 SGTC_1463 k081-0032 34.1 µM -0.429376677608031 0.297725493365455 no 2378 0.333824561797362 732 977755 SGTC_1179 1021-1431 9.29 µM -0.430171160596396 0.297402197229322 no 2379 0.333535569449845 759 2840958 SGTC_3285 9112818 20.8695 µM -0.431362929304603 0.296917535943944 no 2380 0.333102250055595 741 17017947 YPR165W RHO1 SGTC_2823 7987624 58.44 µM -0.432890783416379 0.296296726671195 no 2381 0.332547058018723 788 2239440 SGTC_2478 5763493 32.33 µM -0.433065923381028 0.296225600515548 no 2382 0.332483439042715 709 1365576 YLR208W SEC13 SGTC_1198 1612-1005 86.7 µM -0.433122543482228 0.296202608180652 no 2383 0.332462873022161 727 6998509 SGTC_189 3970-0742 2.116 µM -0.433335364195942 0.296116193101565 no 2384 0.332385575036723 752 2891807 SGTC_1269 0831-0796 3.05 µM -0.433876695846294 0.295896439501801 no 2385 0.332188991692436 757 927758 SGTC_2921 7974240 10.71 µM -0.434460691402958 0.295659450502699 no 2386 0.331976966817509 751 2979074 YDR527W RBA50 SGTC_2210 7115885 190.385 µM -0.435428163314487 0.295267036530236 no 2387 0.33162583577292 753 2927039 SGTC_2218 6965428 192.983 µM -0.436584634044045 0.294798277991675 no 2388 0.331206304192711 724 675684 SGTC_661 1304-0007 33.6 µM -0.438878064882076 0.293869685576571 no 2389 0.330374945717113 710 3117130 SGTC_1899 st063254 59.6 µM -0.439594693412733 0.293579805897687 no 2390 0.330115342398284 733 3093813 SGTC_1810 st050138 53 µM -0.440238781779452 0.293319382091312 no 2391 0.329882086992137 773 3444541 SGTC_1222 0366-0074 1.18 µM -0.440261513199019 0.293310193068273 no 2392 0.329873856058429 744 286520 SGTC_222 nsc-310342 10.666 µM -0.442744611194934 0.292307221749657 no 2393 0.328975235356393 756 432556 SGTC_592 k241-0073 46.5 µM -0.443128475589131 0.292152313958436 no 2394 0.328836404765228 763 4230158 SGTC_3131 9127911 49.47 µM -0.443245844921455 0.292104957400799 no 2395 0.328793961014532 748 45595681 SGTC_1515 3460-0031 42.1 µM -0.443742713883491 0.29190451869273 no 2396 0.328614304961932 748 2876596 SGTC_273 hydroxyurea 18.1 mM -0.443992643919916 0.291803720246871 no 2397 0.328523951147828 742 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_1901 st060216 58.6 µM -0.444141170721923 0.291743826083044 no 2398 0.328470261017931 720 688792 SGTC_2753 fluvastatin 17.09 µM -0.445966830005244 0.291008088424213 no 2399 0.327810603178344 737 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_2142 5622915 118.518 µM -0.447895087067836 0.290231946636001 no 2400 0.327114457114981 713 5322196 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.449240389539034 0.289691024539327 no 2401 0.326629127125122 725 688761 SGTC_2184 6075246 200 µM -0.450923551652302 0.289014922197398 no 2402 0.326022324243665 736 2267320 SGTC_2224 6650123 117.647 µM -0.451259905687953 0.288879902593825 no 2403 0.325901119177601 734 2908370 SGTC_2760 etidronate 98.04 µM -0.45182204554271 0.288654314090866 no 2404 0.325698593334066 737 3305 A chelator and antioxidant. SGTC_681 1642-0006 26.6 µM -0.452514646271663 0.288376485372421 no 2405 0.325449136216028 754 4446530 SGTC_2033 5192550 145 µM -0.455194560799711 0.287302658252784 no 2406 0.324484636624258 710 182073 SGTC_1067 clotrimazole 1.36 µM -0.455353174156994 0.287239162096389 no 2407 0.324427588577157 749 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_2822 7994718 71.43 µM -0.456305548935687 0.286858046812197 no 2408 0.324085137137424 774 1018011 SGTC_1854 st056233 32.9 µM -0.456425162228051 0.28681019766863 no 2409 0.32404213753916 769 5393174 SGTC_2671 danthron 100 µM -0.458200991325122 0.286100254596272 no 2410 0.323404023873016 745 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_1796 st049173 110.4 µM -0.45871581470241 0.285894594110817 no 2411 0.323219127912824 777 94134 SGTC_2437 5741531 144.16 µM -0.460141524951473 0.285325421721278 no 2412 0.322707319972774 753 2262990 SGTC_3264 9137442 49.47 µM -0.460618078044104 0.285135292514763 no 2413 0.32253631958614 752 17015726 SGTC_1933 st074711 15.9 µM -0.462607912658838 0.284342066314473 no 2414 0.321822717956947 752 17250958 SGTC_1623 st003709 20.3 µM -0.463584481560749 0.283953153786805 no 2415 0.321472737365621 718 16192618 SGTC_2394 5221648 200 µM -0.465611338637771 0.283146783874822 no 2416 0.320746862703734 747 788586 SGTC_125 0133-0007 11.75 µM -0.465640933657228 0.283135017861245 no 2417 0.320736268959047 756 26541 SGTC_2604 4'-hydroxychalcone 11.32 µM -0.466321656652044 0.28286444940017 no 2418 0.320492639702601 744 5282362 SGTC_543 3844-1095 191 µM -0.467316398065168 0.2824692908067 no 2419 0.320136763028605 757 4230703 SGTC_2316 5844804 197.44 µM -0.468365791677024 0.282052709723112 no 2420 0.319761513374127 748 776813 SGTC_433 pimozide 108 µM -0.469247539369229 0.281702908455574 no 2421 0.319446354287412 739 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_3349 9149703 23.001 µM -0.470495603458275 0.2812081423274 no 2422 0.319000487301166 751 4910494 SGTC_3228 9131799 49.47 µM -0.47116673897461 0.280942259788797 no 2423 0.318760834423187 750 17015818 SGTC_1681 tripelennamine 100 µM -0.471319338677932 0.280881821599767 no 2424 0.318706353825098 708 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_808 0711-0032 135 µM -0.471493264945069 0.280812944539786 no 2425 0.318644264071778 761 4252555 SGTC_3122 9126309 49.47 µM -0.471966800498406 0.280625459708317 no 2426 0.318475242923691 769 17591206 SGTC_907 3448-6986 75.5 µM -0.474382033816911 0.279670150404199 no 2427 0.317613751210161 767 590582 SGTC_3328 9140624 29.0385 µM -0.474704753142437 0.279542623250501 no 2428 0.317498714795033 767 4904392 SGTC_2315 7733312 200 µM -0.474758337486893 0.279521451364459 no 2429 0.317479615844436 730 726316 SGTC_3087 9117406 49.47 µM -0.475757137587007 0.27912695476111 no 2430 0.317123704689573 732 42546093 SGTC_171 k064-0041 9.68 µM -0.476035367531054 0.279017110357048 no 2431 0.31702459068476 728 53325 SGTC_1374 2889-5571 141 µM -0.478779966364169 0.277934678430086 no 2432 0.316047585085684 751 2853281 SGTC_3191 9110352 49.47 µM -0.480714237834077 0.277173061604161 no 2433 0.315359805278489 757 17122424 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.481105316633785 0.27701919903059 no 2434 0.315220824807269 761 688667 SGTC_2233 sulbentine 40.3845 µM -0.48119328591835 0.276984594936424 no 2435 0.315189566134821 752 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_851 0394-0702 453 µM -0.48142453451663 0.276893639777031 no 2436 0.315107401444927 762 762646 SGTC_3279 9140807 49.47 µM -0.48298994321817 0.27627831500581 no 2437 0.314551438471294 756 45595718 SGTC_2037 5169046 200 µM -0.484761105563884 0.275582923370594 no 2438 0.313922907749689 745 5718022 SGTC_689 0833-0039 98 µM -0.486127319826811 0.275047110631954 no 2439 0.313438449019436 789 5374726 SGTC_3319 9138450 16.7555 µM -0.486393940688062 0.274942605024256 no 2440 0.313343942916079 758 2029690 SGTC_3079 9117512 49.47 µM -0.48988444960128 0.27357626097787 no 2441 0.312107833735201 786 7185044 SGTC_1558 st069300 45.6 µM -0.490681077267132 0.273264896273759 no 2442 0.311826016078963 759 24208000 SGTC_824 1304-0008 100 µM -0.491031453993439 0.273128005911163 no 2443 0.311702100506973 740 768245 SGTC_1934 st074720 32.6 µM -0.491734065318679 0.272853601766334 no 2444 0.311453676547231 750 17250992 SGTC_1732 st034308 51.822 µM -0.491870270491329 0.272800422800901 no 2445 0.311405528087375 723 830119 SGTC_1607 st000305 50.6 µM -0.492882375502971 0.27240542494447 no 2446 0.31104785055832 779 5457690 SGTC_685 1278-0033 54.9 µM -0.494617904933181 0.271728755531858 no 2447 0.310434930470903 760 3590572 SGTC_835 0312-0010 67.2 µM -0.494669223139112 0.271708759705261 no 2448 0.31041681491666 759 1626196 SGTC_1260 0700-1617 7.75 µM -0.494791841998291 0.271660984979135 no 2449 0.310373531777862 733 2853078 SGTC_654 1124-0271 80.9 µM -0.494890984227448 0.271622360269009 no 2450 0.310338537556927 762 5403748 SGTC_521 r062-0005 13.8 µM -0.495276739850149 0.271472100189906 no 2451 0.31020239377953 750 2832033 SGTC_3077 9117319 49.47 µM -0.495714330953213 0.271301699222217 no 2452 0.310047987320831 778 17154678 SGTC_2207 7258803 200 µM -0.496220555181534 0.27110463857507 no 2453 0.309869405064196 788 3666799 SGTC_1554 st069299 38.7 µM -0.49788879155084 0.270455740814673 no 2454 0.309281213910479 740 24207999 SGTC_1881 5652484 16 µM -0.498103531656646 0.270372269276339 no 2455 0.309205535731405 770 2255129 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.500089906489116 0.269600757319173 no 2456 0.308505886480002 762 616764 SGTC_2663 amphotericin b 100 µM -0.500113038520048 0.269591779293661 no 2457 0.3084977429072 758 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1855 st056195 39.6 µM -0.502082995502414 0.268827747771925 no 2458 0.307804570522584 727 4028379 SGTC_3222 9128301 49.47 µM -0.502855555829609 0.268528413776527 no 2459 0.307532915255812 759 4911358 SGTC_1965 Pectolinarigenin 58.4 µM -0.50327411753364 0.268366309071815 no 2460 0.30738578053041 768 5320438 An anti-inflammatory. SGTC_2334 9017922 200 µM -0.504103869255309 0.268045100198614 no 2461 0.30709419404 759 3163164 SGTC_1516 st013856 110 µM -0.504118620414771 0.268039391563247 no 2462 0.30708901137667 764 5281404 A mutagen and neurotoxin. SGTC_1518 st038567 90.8 µM -0.505493990392757 0.26750739833236 no 2463 0.306605959161438 776 77966 SGTC_2934 9036370 36.88 µM -0.505608089165407 0.26746328884553 no 2464 0.306565900895628 741 6462800 SGTC_2029 5175081 200 µM -0.507005549535344 0.266923341876797 no 2465 0.306075462362993 750 1380876 SGTC_128 0906-2981 13.371 µM -0.507339456168599 0.266794409481101 no 2466 0.305958329262148 779 6740226 SGTC_3220 9131269 49.47 µM -0.509146157287416 0.266097328702934 no 2467 0.305324890160171 776 17722206 SGTC_1033 k072-0102 21.3 µM -0.509724442240546 0.265874403626473 no 2468 0.305122263324424 790 5965931 SGTC_162 k030-0015 37.8 µM -0.509742074091937 0.265867608149866 no 2469 0.305116086190027 771 1809920 YMR134W ERG29 SGTC_16 erodoxin 22.806 µM -0.511185800193643 0.265311481751924 no 2470 0.304610480393095 774 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_3146 9095609 49.47 µM -0.512444197139547 0.264827226663827 no 2471 0.304170082752931 749 17173999 SGTC_759 3486-0358 89.3 µM -0.513569405616693 0.264394605860452 no 2472 0.303776537111593 800 875103 SGTC_2117 5521686 200 µM -0.513652283587848 0.264362755120258 no 2473 0.303747559233467 753 803312 SGTC_2995 9067767 71.4286 µM -0.51870839876638 0.262423346645679 no 2474 0.301982051970399 772 11673567 SGTC_2800 7887935 81.82 µM -0.518921869679903 0.262341624723582 no 2475 0.301907613157794 788 2961002 SGTC_1057 3448-5381 134 µM -0.519325557401349 0.262187118759892 no 2476 0.301766866945018 755 5497911 SGTC_1486 3970-0793 4.53 µM -0.519747589576132 0.262025641571891 no 2477 0.301619756461876 777 2844330 SGTC_2349 9023730 187.07 µM -0.520533840273002 0.261724943770543 no 2478 0.301345774037237 778 4126287 SGTC_1420 4'-methoxyflavone 42 µM -0.521536042384958 0.261341913222665 no 2479 0.30099670221301 769 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_558 k064-0027 21.3 µM -0.522974923674363 0.260792492620662 no 2480 0.300495851931278 749 5088526 SGTC_940 3232-1287 54.8 µM -0.523099962589559 0.260744775999935 no 2481 0.300452345777542 789 1585493 YIL048W NEO1 SGTC_2961 9083290 32.55 µM -0.523136002048125 0.260731023666249 no 2482 0.300439806703846 784 17741490 SGTC_864 0469-0573 172 µM -0.524021392820821 0.260393283758134 no 2483 0.300131830285724 785 689425 SGTC_2060 5238662 140 µM -0.524119120810568 0.260356018392134 no 2484 0.30009784510209 781 790130 SGTC_3332 9141069 11.198 µM -0.524646476086358 0.260154976163135 no 2485 0.299914485865925 762 17332883 SGTC_2895 9054447 58.44 µM -0.524966371534417 0.260033062288328 no 2486 0.299803284263716 757 2697450 SGTC_3251 9135047 49.47 µM -0.526355863927311 0.259503861350325 no 2487 0.299320487697152 754 17682963 SGTC_1860 st056228 74.6 µM -0.526518032934308 0.259442134059736 no 2488 0.299264163029815 804 688679 SGTC_2864 9034755 47.6 µM -0.527613947304109 0.259025188972852 no 2489 0.298883655302126 750 4930451 SGTC_1170 0310-0127 64.8 µM -0.527775839903306 0.25896362566323 no 2490 0.29882746390534 792 774975 SGTC_513 4245-1575 41.7 µM -0.528440007624016 0.258711140156047 no 2491 0.29859698780452 770 719745 SGTC_3327 9140648 26.9345 µM -0.52994386903773 0.258139913647404 no 2492 0.298075424477099 775 8029710 SGTC_2403 6032726 181.2 µM -0.53142812890406 0.257576774479536 no 2493 0.297561066690294 754 2881040 SGTC_2487 5918373 44.05 µM -0.532494987376805 0.257172394947656 no 2494 0.297191606318933 784 2876279 SGTC_3020 9089140 49.47 µM -0.532541842799845 0.257154642547981 no 2495 0.297175384774033 766 17217859 SGTC_2529 gangaleoidin 93.61 µM -0.533120853785421 0.256935321726532 no 2496 0.296974962144494 788 4565183 SGTC_611 3453-1652 23.7 µM -0.53330548091958 0.256865408161101 no 2497 0.296911067111652 786 1560575 SGTC_2787 5284540 71.43 µM -0.533862319571413 0.256654607602519 no 2498 0.296718396685508 781 736958 SGTC_1023 4482-3888 16 µM -0.534805555628494 0.256297735505088 no 2499 0.296392160492056 770 3303168 SGTC_2727 riluzole 51.77 µM -0.535227375305108 0.256138224338202 no 2500 0.296246319334361 773 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_2897 9048598 12.99 µM -0.536278928725728 0.255740804783867 no 2501 0.29588289558318 772 6467404 SGTC_1166 k206-0078 225 µM -0.537142265303567 0.255414759910324 no 2502 0.295584673952753 754 5404595 SGTC_900 1112-0045 141 µM -0.539101557766177 0.254675626578745 no 2503 0.294908390392505 772 56211 YIL048W NEO1 SGTC_1262 0737-0114 49.6 µM -0.539370453946453 0.254574274316721 no 2504 0.294815631916035 792 765919 SGTC_2836 9010338 19.48 µM -0.540717046429271 0.254067035128047 no 2505 0.294351313582349 743 2994051 SGTC_2203 7227154 166.4 µM -0.541169010026897 0.253896906807323 no 2506 0.294195547809748 756 896304 SGTC_1065 prochlorperazine maleate 2.48 µM -0.541315866970254 0.253841639730251 no 2507 0.294144942894238 803 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_1414 3917-0015 5.4 µM -0.544105668195448 0.252792946789693 no 2508 0.293184380081235 783 6618702 SGTC_2796 7949634 45.45 µM -0.545950485153874 0.252100730650691 no 2509 0.292549986909475 766 2971588 SGTC_2240 6690706 185.951 µM -0.547159591807931 0.251647590101067 no 2510 0.292134547290443 752 805876 SGTC_1661 st013063 9.66 µM -0.547583393574748 0.251488862517975 no 2511 0.291988997315089 793 721395 SGTC_367 0335-0881 7.1 µM -0.547937289981454 0.251356357318002 no 2512 0.291867481429355 796 23828853 SGTC_2091 4-phenylthiadiazole 200 µM -0.548039606251656 0.251318055138885 no 2513 0.291832353922271 783 270010 SGTC_1824 st053723 68.6 µM -0.548067874155352 0.25130747357015 no 2514 0.29182264925403 788 675225 SGTC_2510 benzyl isothiocyanate 8.31 µM -0.548649078403128 0.251089962691852 no 2515 0.291623149064172 792 2346 DNA damaging agent; causes G2/M arrest. SGTC_2793 7325131 81.82 µM -0.549098422100733 0.250921867820929 no 2516 0.291468954018329 759 4176441 SGTC_2264 7948757 110.76 µM -0.54913343427935 0.250908772625498 no 2517 0.291456940971716 783 2971411 SGTC_257 daunorubicin 18.5 µM -0.549267916598352 0.250858477140733 no 2518 0.291410800821496 776 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2677 mitomycin C 100 µM -0.549382867826693 0.250815490383772 no 2519 0.291371364383539 788 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_618 k072-0232 33.2 µM -0.550202491163881 0.250509099994253 no 2520 0.291090247555272 786 5872756 YGL099W LSG1 SGTC_3192 9110362 49.47 µM -0.55044338280316 0.250419087960558 no 2521 0.291007649924213 785 16649480 SGTC_1005 4092-0690 4.4 µM -0.550918277461435 0.250241688128206 no 2522 0.29084484873158 797 1529343 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -0.550970348438052 0.250222240748215 no 2523 0.290827000590322 797 364106 SGTC_361 000s-0510 1.45 µM -0.552359980064067 0.249703539724393 no 2524 0.290350871908412 772 660 SGTC_3113 9123498 49.47 µM -0.552504957922382 0.249649457460015 no 2525 0.290301219262554 794 8897275 SGTC_3035 9091303 49.47 µM -0.554142235510267 0.249039122669369 no 2526 0.289740753575573 784 25237002 SGTC_1239 0337-0584 35.4 µM -0.554373024481419 0.248953154387666 no 2527 0.289661791754883 780 914301 YML130C ERO1 SGTC_120 rhodamine 6G 52.259 µM -0.55439563362672 0.248944733390252 no 2528 0.289654056836299 810 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_649 1123-0311 367 µM -0.554564542706917 0.248881826347425 no 2529 0.28959627364271 789 693629 YIL048W NEO1 SGTC_2871 9038510 12.99 µM -0.554848794118317 0.248775981304366 no 2530 0.289499044467934 815 4945164 SGTC_2930 9013230 14.89 µM -0.555086369710712 0.248687535054714 no 2531 0.289417792681059 773 2995857 SGTC_720 r052-1644 49.9 µM -0.5559760394978 0.248356471598274 no 2532 0.289113617328577 794 1422863 YOR257W CDC31 SGTC_1128 3448-9350 235 µM -0.556172347355264 0.248283453272216 no 2533 0.289046520529458 736 619386 SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.556613101620458 0.24811955279723 no 2534 0.288895900165113 767 5377381 SGTC_3032 9089427 49.47 µM -0.556962654473275 0.24798960785614 no 2535 0.288776472620407 774 17173707 SGTC_2072 5231554 129 µM -0.557347188745489 0.24784670066337 no 2536 0.28864512024787 788 789545 SGTC_1102 cgs 12066b 26.1 µM -0.557897577053821 0.247642232476314 no 2537 0.288457163073419 754 6438352 A 5-HT1B full agonist. SGTC_68 0986-0284 82.829 µM -0.558380215062174 0.247463007563159 no 2538 0.288292390059426 767 423278 YIL048W NEO1 SGTC_82 0054-0107 293.755 µM -0.558462341101949 0.247432517421823 no 2539 0.288264356581328 784 3104697 SGTC_596 1155-0152 116 µM -0.559303961635113 0.247120172840793 no 2540 0.287977146052286 784 280313 SGTC_1461 k072-0203 53.8 µM -0.560030697475934 0.246850634362206 no 2541 0.287729249694126 784 5418714 SGTC_1197 1601-0112 267 µM -0.560271969234348 0.24676118407868 no 2542 0.287646971951143 781 7350313 SGTC_2182 6325192 200 µM -0.560480715781909 0.246683806357692 no 2543 0.287575794827625 773 736248 SGTC_1259 0671-0132 43 µM -0.560559339640651 0.246654665603986 no 2544 0.287548988302958 763 X1259 SGTC_1626 st003712 1.76 µM -0.560702811619138 0.246601494619538 no 2545 0.287500075087781 805 24207035 SGTC_321 4534-3890 65.3 µM -0.561139724292213 0.246439611786717 no 2546 0.287351144779143 781 699746 SGTC_3267 9137951 49.47 µM -0.56182492241798 0.246185850121905 no 2547 0.287117655004418 793 16643986 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.56185128791654 0.246176088516132 no 2548 0.287108672428235 782 5024745 SGTC_748 act1.228 77.9 µM -0.562025770701925 0.246111492953699 no 2549 0.287049230484762 766 4421505 YNR035C ARC35 SGTC_1548 st061468 90.8 µM -0.563658715092469 0.245507398810809 no 2550 0.286493209667578 781 390799 SGTC_2721 ifenprodil 61.44 µM -0.563958284263823 0.245396662237775 no 2551 0.28639126126797 770 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_160 3453-0671 289.699 µM -0.564997920550035 0.245012566120383 no 2552 0.286037589286259 814 5322268 SGTC_2070 5230947 200 µM -0.566577762110264 0.244429509583972 no 2553 0.285500543530009 809 2835538 SGTC_47 0149-0135 24.25 µM -0.566719245906822 0.244377330054769 no 2554 0.285452471457218 762 5239155 SGTC_2781 5567276 71.43 µM -0.566796978116938 0.244348664803275 no 2555 0.285426061956953 797 2853274 SGTC_830 4076-0286 57.8 µM -0.567169838726436 0.244211190460528 no 2556 0.285299398829959 781 6866659 SGTC_2572 astragaloside iv 100 µM -0.568454791767874 0.24373774572798 no 2557 0.284863097355084 775 45006101 An anti-inflammatory agent. SGTC_2512 diallyl trisulfide 49.23 µM -0.569429558585087 0.243378920800824 no 2558 0.284532331042674 805 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_2111 5486399 200 µM -0.569870353201765 0.243216752080537 no 2559 0.28438281705218 767 689674 SGTC_2792 7535235 81.82 µM -0.570878133149889 0.242846208517715 no 2560 0.28404112729966 755 1281891 SGTC_2893 9048488 25.97 µM -0.57105429214439 0.242781469229709 no 2561 0.283981420421668 770 6467338 SGTC_1293 1000-1278 195 µM -0.571246599560935 0.242710805983931 no 2562 0.283916247096027 800 678847 SGTC_1781 st038725 66.3 µM -0.572902600290836 0.242102770492829 no 2563 0.283355321936193 766 4270275 YIL048W NEO1 SGTC_2686 alizarin 95.37 µM -0.573124220201585 0.242021460791699 no 2564 0.283280294558559 751 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_507 nimesulide 162 µM -0.573947285571046 0.241719617607058 no 2565 0.283001736796027 789 4495 A COX2 inhibitor. SGTC_165 k038-0023 64.381 µM -0.574746869123258 0.241426581701156 no 2566 0.282731252186925 774 46368543 SGTC_1991 st073000 8.92 µM -0.576148298880705 0.240913443641473 no 2567 0.28225747378737 806 4301969 YIL048W NEO1 SGTC_287 k060-0039 29.6 µM -0.577012597893156 0.240597273754982 no 2568 0.281965472641217 788 5861974 SGTC_2883 9059145 45.46 µM -0.57743707076063 0.240442079761554 no 2569 0.281822118899438 810 16476510 SGTC_1945 st075991 56.6 µM -0.577494949157218 0.240420922729148 no 2570 0.281802574824478 775 1084980 SGTC_3059 1327-0034 3 µM -0.579542037020358 0.239673276996554 no 2571 0.281111745334596 775 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2168 5727979 200 µM -0.580617321518202 0.239281066113767 no 2572 0.280749197735914 778 695210 SGTC_3167 9103034 49.47 µM -0.581018047726518 0.239134990644648 no 2573 0.280614145006179 781 5127859 SGTC_2894 9048625 32.47 µM -0.581386859831818 0.239000591804779 no 2574 0.280489875750093 811 4092861 SGTC_1864 st057645 30.4 µM -0.581890059077022 0.238817287569304 no 2575 0.280320368446243 805 688666 SGTC_1322 1348-1070 12 µM -0.582299659286078 0.238668136162904 no 2576 0.280182427477109 786 6758089 SGTC_2446 5162541 200 µM -0.582387897211764 0.23863601196828 no 2577 0.280152715917111 787 1549321 SGTC_272 doxorubicin 8.13 µM -0.582717150348918 0.238516163859509 no 2578 0.280041862960145 773 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1803 st050068 52.4 µM -0.583128554534792 0.238366459096138 no 2579 0.279903381273837 795 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_2385 9074692 200 µM -0.584236736500603 0.237963461849249 no 2580 0.279530524336293 770 17046906 SGTC_2388 9080168 200 µM -0.584373563179665 0.237913729898142 no 2581 0.279484504606145 807 15943073 SGTC_2782 7736369 71.43 µM -0.584567389926825 0.237843290071685 no 2582 0.279419320002479 792 2950836 YOL077C BRX1 SGTC_554 4483-2211 187 µM -0.584598181194549 0.237832101071636 no 2583 0.279408965472693 778 747107 SGTC_841 0251-0215 91.2 µM -0.584690959173754 0.237798388946469 no 2584 0.279377767093378 796 3888614 SGTC_3193 9111931 49.47 µM -0.585047224113467 0.237668959652893 no 2585 0.279257981885705 821 17087244 SGTC_1253 0550-0034 176 µM -0.585903820646907 0.23735792060653 no 2586 0.278970074839635 783 5969915 SGTC_1442 4112-3290 3 µM -0.586663347388817 0.237082315667511 no 2587 0.278714914338881 807 704353 SGTC_275 trichlorophene 5.69 µM -0.587742361520408 0.236691082786545 no 2588 0.278352618576652 787 62616 SGTC_327 1273-0057 3.96 µM -0.588651920142428 0.236361567744179 no 2589 0.278047398537265 801 3108138 SGTC_341 1486-1430 230 µM -0.588789059752328 0.236311906704019 no 2590 0.278001392850418 808 2054753 YPL210C SRP72 SGTC_2251 lansoprazole 556 µM -0.590094165780565 0.235839588892905 no 2591 0.277563760017768 800 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.590414520188243 0.235723732249829 no 2592 0.277456389109114 823 688798 SGTC_1800 st050079 29.0735 µM -0.593241438325765 0.23470273481245 no 2593 0.276509792086767 796 3645560 SGTC_3296 9122258 64.045 µM -0.593443344070066 0.234629906231813 no 2594 0.276442244330685 797 4730474 SGTC_1925 st057770 10.1 µM -0.593955691999004 0.23444515544988 no 2595 0.276270874179513 786 5989122 SGTC_1887 st057648 70.8 µM -0.596128921501985 0.233662392368761 no 2596 0.275544552314597 813 688672 SGTC_1941 st076221 61.8 µM -0.597805670518897 0.233059445336707 no 2597 0.274984803295088 782 2828568 SGTC_874 0599-0792 117 µM -0.598920001851278 0.232659218048763 no 2598 0.274613116261054 810 765305 SGTC_1452 4194-0072 190 µM -0.598989141764088 0.23263439810021 no 2599 0.274590062697684 806 1343545 SGTC_3210 9128157 49.47 µM -0.5990791592972 0.232602085678274 no 2600 0.274560049266922 795 17590849 SGTC_235 0330-0087 5 mM -0.599145511934042 0.232578269533555 no 2601 0.274537927165509 787 46494818 YHR062C RPP1 SGTC_2380 9035439 200 µM -0.600738097459832 0.232007045141611 no 2602 0.274007219992427 787 6462575 SGTC_2832 7992762 51.95 µM -0.602276050721741 0.231456158311474 no 2603 0.273495199942372 769 2985177 SGTC_3189 9110682 49.47 µM -0.603164186796498 0.231138365096279 no 2604 0.273199734866388 801 17122418 SGTC_1081 sertraline 6 µM -0.603315558016082 0.231084225680535 no 2605 0.273149392473552 802 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_2830 7992007 71.43 µM -0.603348325110946 0.231072507136447 no 2606 0.273138495538548 804 1952075 SGTC_2682 pyrogallin 40.03 µM -0.605983351656513 0.230131225207867 no 2607 0.272262904237849 795 822798 An ATP competetive kinase inhibitor. SGTC_870 0573-2213 57.6 µM -0.60624428013839 0.230038133428769 no 2608 0.272176276432664 796 3916321 SGTC_2490 carminic acid 95.39 µM -0.606894519249405 0.229806238525651 no 2609 0.271960457799071 785 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2 0422-0095 29 µM -0.607027796931928 0.229758723848057 no 2610 0.271916232573841 768 6790840 SGTC_2818 7996756 12.99 µM -0.60743494689493 0.229613605348937 no 2611 0.271781151104914 826 2241621 SGTC_1497 4476-2978 41.3 µM -0.608771150464026 0.229137709701157 no 2612 0.271338069272808 802 1528379 SGTC_2272 7805186 180 µM -0.609800591946547 0.228771446515853 no 2613 0.270996954674318 826 2956062 YPR165W RHO1 SGTC_1873 rapamycin 2 nM -0.609809745781185 0.228768191163959 no 2614 0.270993922429612 778 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_1080 nisoldipine 24.4 µM -0.611431226868944 0.22819195895885 no 2615 0.270457067466245 818 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_2024 5144227 134 µM -0.613060537650589 0.227613767131559 no 2616 0.269918156023353 781 3475211 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.614397187725573 0.227140048063496 no 2617 0.269476446852608 788 6708784 An antioxidant flavonoid SGTC_441 propafenone 146 µM -0.618233988680139 0.225783348161616 no 2618 0.268210554147642 815 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_688 0527-0193 473 µM -0.618901229575133 0.225547879292298 no 2619 0.267990714225597 823 4007154 SGTC_401 neomycin 50 µM -0.619251254088945 0.225424411471503 no 2620 0.26787542580906 775 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_2643 anethole 100 µM -0.619453853670259 0.225352963881527 no 2621 0.267808706513624 833 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.619603255697356 0.225300284846744 no 2622 0.267759511390649 832 368090 SGTC_2723 salbutamol 83.58 µM -0.620699182889491 0.224914075064009 no 2623 0.267398783574031 814 9884233 β2-adrenoceptor agonist SGTC_389 tpck 16.7 µM -0.621010688357672 0.224804367637123 no 2624 0.267296295347261 789 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_52 0329-0193 875 nM -0.62221862466231 0.224379238148068 no 2625 0.266899060489096 828 3739292 SGTC_2892 9047358 58.44 µM -0.622957293029292 0.224119491084351 no 2626 0.266656293368908 807 6466771 SGTC_363 0455-0021 3.06 µM -0.62343445692081 0.223951790896597 no 2627 0.266499530396971 800 4597466 SGTC_673 1082-0474 110 µM -0.623473779992594 0.223937973906476 no 2628 0.266486613641236 814 3098046 SGTC_1951 sophoraflavanone G 9.2 µM -0.624348479821952 0.223630754933207 no 2629 0.266199376062541 794 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_1300 1094-0077 113 µM -0.625148181273341 0.223350087330635 no 2630 0.265936903990396 812 5532636 SGTC_2521 angolensin 13.4 µM -0.625959259140385 0.223065631856524 no 2631 0.265670832034044 814 821428 A flavenoid. SGTC_2421 5690543 90.72 µM -0.626184526998016 0.222986664132974 no 2632 0.265596957465868 822 3397993 SGTC_1897 st060201 15 µM -0.628045988986909 0.222334737705699 no 2633 0.264986906759268 799 611878 SGTC_569 4130-2812 160 µM -0.628612996984251 0.222136374832677 no 2634 0.264801224692799 818 743552 SGTC_209 4077-0173 175.592 µM -0.6292449125109 0.221915423681663 no 2635 0.264594364872647 790 15993494 SGTC_1062 mesoridazine 14.2 µM -0.629970140621053 0.22166200024772 no 2636 0.264357060195078 804 4078 A neuroleptic. SGTC_627 1391-0720 175 µM -0.630054645757143 0.221632481566434 no 2637 0.264329415994182 838 997839 SGTC_442 cape 100 µM -0.631356972909502 0.221177846873406 no 2638 0.263903571358161 797 5281787 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.632321026742916 0.220841645327346 no 2639 0.263588563268638 797 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1126 isoteolin 1.0172 µM -0.632322712145186 0.22084105782102 no 2640 0.263588012725374 802 133323 SGTC_2654 protoveratrine a 100 µM -0.632637324407897 0.220731404311258 no 2641 0.263485253673441 836 5702278 A heart drug and vasodilator. SGTC_1450 4112-4260 37.6 µM -0.634816661296484 0.219972684907909 no 2642 0.262773997740051 817 1633175 SGTC_516 3992-2719 87.3 µM -0.635176270644365 0.219847633663281 no 2643 0.262656728849809 785 5350887 YDR037W KRS1 SGTC_475 α-linolenic acid 10 µM -0.635751471261683 0.219647697149164 no 2644 0.262469211162634 803 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2242 6630449 61.2675 µM -0.636661122908424 0.219331720556645 no 2645 0.26217280107091 791 691249 YDR170C SEC7 SGTC_740 k014-0057 261 µM -0.6379834728431 0.218872855287716 no 2646 0.261742219298139 814 4012779 SGTC_943 3253-1379 105 µM -0.638069760777886 0.218842931940199 no 2647 0.261714134954153 825 668464 SGTC_2975 9084847 53.72 µM -0.641437577382242 0.217676864267054 no 2648 0.260619212599691 778 27211724 SGTC_1838 st055369 84.5 µM -0.643636383477731 0.216917491272674 no 2649 0.259905625665722 790 676036 SGTC_137 0438-0332 85.389 µM -0.645830322437377 0.216161327638895 no 2650 0.259194624108239 838 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_2493 resveratrol 26.09 µM -0.64665326360114 0.215878086646945 no 2651 0.258928188676725 793 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_1224 0823-0416 294 µM -0.647429578672909 0.215611090728903 no 2652 0.258676978835679 815 3598164 SGTC_339 3091-4833 71.4 µM -0.647717880911872 0.215511984509007 no 2653 0.258583718492822 817 3240077 SGTC_2005 4024620 188 µM -0.647730158340335 0.215507764630571 no 2654 0.258579747362555 825 236743 SGTC_1271 0832-2808 169 µM -0.649321403134603 0.214961243177379 no 2655 0.258065327163217 831 3663794 SGTC_853 0419-0306 21 µM -0.649440583584293 0.214920342446745 no 2656 0.258026819689009 820 762713 SGTC_3088 9117578 49.47 µM -0.650183445440014 0.214665506633277 no 2657 0.257786866531765 832 678341 SGTC_1408 3909-7976 48.8 µM -0.65049522115048 0.214558605551288 no 2658 0.257686193808395 819 24152374 SGTC_227 fluconazole 33.516 µM -0.650794930203043 0.214455871042056 no 2659 0.257589436667522 830 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_1040 k898-0338 155 µM -0.651016632372145 0.214379894202858 no 2660 0.257517875169079 829 20969351 SGTC_3068 9116768 49.47 µM -0.651309729053152 0.21427947465448 no 2661 0.257423284650493 822 41904888 SGTC_1664 st014217 9.02 µM -0.651669902338488 0.214156111082615 no 2662 0.257307071357256 822 3982782 SGTC_343 4130-2827 29.8 µM -0.65178956334439 0.214115134932937 no 2663 0.257268467645229 802 1118244 SGTC_3201 9113999 49.47 µM -0.652345873628551 0.213924694588229 no 2664 0.257089036506106 815 16649224 SGTC_2984 9022109 38.96 µM -0.65332154970408 0.21359093202137 no 2665 0.256774501254389 842 6459207 SGTC_1928 4'-methoxychalcone 40.3 µM -0.654102176639536 0.213324111145607 no 2666 0.256522989629052 811 641818 SGTC_1394 3474-0001 65.7 µM -0.655264702868798 0.212927116230623 no 2667 0.256148671169402 795 5017666 YIL048W NEO1 SGTC_2345 9052315 157.45 µM -0.65536626281623 0.212892454679327 no 2668 0.256115983709512 816 6469265 SGTC_3107 9121808 49.47 µM -0.655678136318564 0.212786035475066 no 2669 0.256015619621738 759 662681 SGTC_2106 5357045 167.29 µM -0.655740327742055 0.212764817887331 no 2670 0.255995608238521 815 668842 SGTC_2992 9074591 71.4286 µM -0.655843334622593 0.212729678178035 no 2671 0.255962465428828 826 17741321 SGTC_1879 gemcitabine 100 µM -0.657056827104859 0.212315963190849 no 2672 0.255572188755025 841 60750 A nucleoside analog which inhibits DNA replication. SGTC_743 1275-0778 158 µM -0.657166037493506 0.212278753260744 no 2673 0.255537080371733 822 2849257 YMR203W TOM40 SGTC_1758 st042942 75.2445 µM -0.658217329794172 0.211920754185386 no 2674 0.25519924533673 819 669317 SGTC_1488 4013-0813 75.9 µM -0.659979500352224 0.211321470824697 no 2675 0.254633492310794 813 2910057 SGTC_2826 7992541 19.48 µM -0.661280027025133 0.210879821853922 no 2676 0.254216373883763 873 2985066 SGTC_1395 3486-0190 4.35 µM -0.661834798264973 0.210691590567092 no 2677 0.254038550967476 831 6748079 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.663625305848609 0.210084752533753 no 2678 0.253465078311716 819 5379071 SGTC_37 0566-0070 1.56 µM -0.664205561786482 0.209888312970706 no 2679 0.253279377120008 817 1626686 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.665835018156668 0.20933725518847 no 2680 0.252758279635306 832 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_1956 st077085 54 µM -0.666642972657295 0.209064333119236 no 2681 0.252500106610739 844 24208685 SGTC_1659 st012954 42.1 µM -0.667318919701746 0.208836163423474 no 2682 0.252284221925325 820 24207262 SGTC_2734 clemastine 41.6 µM -0.668075292789294 0.208581019497419 no 2683 0.252042766109951 854 26987 Clemastine is a selective histamine H1 antagonist. SGTC_1114 scopoletin 1.73284 µM -0.668629860618175 0.208394066452618 no 2684 0.251865809776226 821 5280460 A coumarin with genotoxic properties. SGTC_1555 citronellol 128 µM -0.672307702052707 0.207156714891711 no 2685 0.250693913745126 821 8842 A terpine precursor. SGTC_2359 9039622 200 µM -0.672504113840048 0.207090757718197 no 2686 0.25063141102833 828 6463596 SGTC_965 1291-5240 308 µM -0.672565102353418 0.207070279652843 no 2687 0.250612004770004 842 2834598 SGTC_603 3794-0023 45.9 µM -0.673859809078031 0.206635839720043 no 2688 0.250200223049502 837 3802260 SGTC_982 1491-0518 27.5 µM -0.674457622528793 0.206435425209537 no 2689 0.250010209530616 830 3091256 SGTC_3272 9137413 49.47 µM -0.674552011216877 0.206403792319331 no 2690 0.249980215321638 838 17614870 SGTC_2064 5220758 200 µM -0.674581609000511 0.206393873677348 no 2691 0.249970810328272 815 788518 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.676468643263761 0.205762084615293 no 2692 0.249371574040437 817 16623 A steroid. SGTC_2326 6164455 177.58 µM -0.676775059466366 0.205659603262608 no 2693 0.249274342298934 827 2888790 SGTC_3182 9108849 49.47 µM -0.676823326371176 0.205643463087233 no 2694 0.249259028121666 811 17133045 SGTC_1007 4101-0031 70 µM -0.676845472434142 0.205636057822781 no 2695 0.249252001761593 842 1146276 SGTC_211 3455-0679 143.504 µM -0.67799990771804 0.205250253649288 no 2696 0.248885875863566 797 748649 SGTC_715 0868-0130 184 µM -0.678451644443981 0.205099403540908 no 2697 0.248742686796267 837 2876258 SGTC_314 1671-0008 2.74 µM -0.679292336052057 0.204818843773709 no 2698 0.248476325736118 838 3913060 SGTC_709 3807-1509 243 µM -0.679301275523256 0.204815861675997 no 2699 0.248473494210004 860 1886677 YPL242C IQG1 SGTC_594 1487-1584 10.8 µM -0.679723380757492 0.204675081954369 no 2700 0.248339814379825 844 5013332 SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.679824763259801 0.204641277633576 no 2701 0.248307712467984 839 165506 SGTC_804 1595-0054 20.9 µM -0.68042007019328 0.204442849394686 no 2702 0.248119258206063 833 761523 Stimulates phospholipase C. SGTC_1733 st037357 54.9 µM -0.680837724921295 0.204303704729371 no 2703 0.247987088242583 833 1272339 YGL099W LSG1 SGTC_2019 4016004 108 µM -0.682145585227644 0.203868346586424 no 2704 0.247573449199238 835 45595336 SGTC_2733 amorolfine 100 µM -0.682441630882642 0.203769876249153 no 2705 0.24747986955691 853 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2816 7982706 58.44 µM -0.682556672564752 0.203731618878954 no 2706 0.247443510132594 835 2981853 SGTC_1362 1611-0397 101 µM -0.683285658821367 0.203489292416655 no 2707 0.247213177227668 828 27816 SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.683296065929728 0.203485834175904 no 2708 0.247209889793624 855 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_2751 anetholtrithion 17.25 µM -0.683850384993359 0.203301686821799 no 2709 0.247034823323553 829 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_929 2805-0021 398 µM -0.683877166858524 0.203292792281663 no 2710 0.247026366686185 857 3098024 SGTC_118 0083-0097 135.343 µM -0.684276425924428 0.203160221669803 no 2711 0.246900315076249 864 5207356 SGTC_1492 4158-0558 28.5 µM -0.684462190979429 0.203098557542991 no 2712 0.246841678215552 801 3967268 SGTC_311 1315-0136 58 µM -0.685068194145746 0.202897474394773 no 2713 0.246650444755573 827 6759207 SGTC_2694 st077685 81.9 µM -0.686254213260454 0.20250427542037 no 2714 0.246276408217139 807 2838096 SGTC_1663 st014140 55.4 µM -0.687826046495582 0.201983870650659 no 2715 0.245781165873808 820 4207120 SGTC_981 1488-1094 54.9 µM -0.688557942905745 0.201741826743741 no 2716 0.24555074757858 832 3449522 SGTC_2783 7738165 71.43 µM -0.689071865871609 0.201571972227317 no 2717 0.245389021851594 835 17201110 SGTC_244 nsc-207895 1.295 µM -0.689097012132293 0.201563663441781 no 2718 0.245381110077911 803 42640 SGTC_105 0111-0055 734.78 µM -0.689229315540269 0.201519951350213 no 2719 0.245339485685 819 5179370 SGTC_1859 st055998 20 µM -0.690612658876952 0.201063244957419 no 2720 0.244904495052408 842 676301 SGTC_650 1328-0195 38 µM -0.690830679998842 0.200991322653202 no 2721 0.24483597645517 842 2780821 SGTC_1522 st012842 45.6 µM -0.691081217682743 0.200908692623314 no 2722 0.244757251456684 832 3491067 YOR116C RPO31 SGTC_1546 5-methoxyflavanone 78.7 µM -0.691085963903324 0.200907127465331 no 2723 0.244755760210947 819 147795 SGTC_1425 4048-4433 7.33 µM -0.691204340296809 0.200868092928132 no 2724 0.244718568348754 870 23734946 SGTC_2090 5301565 104.445 µM -0.691898665295502 0.200639231364263 no 2725 0.244500484445834 832 2056344 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.692316892658088 0.200501451952177 no 2726 0.244369171931414 840 688788 SGTC_1612 st002233 45.4 µM -0.695106101009047 0.199584038522856 no 2727 0.243494405804073 820 1035021 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.695767615619028 0.199366827403043 no 2728 0.24328718657409 831 115019 SGTC_2095 5432005 200 µM -0.696180648341421 0.19923127856882 no 2729 0.243157852563464 853 783734 SGTC_1874 staurosporine 7.6 µM -0.696900271646095 0.198995245659353 no 2730 0.242932603883394 832 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_914 3820-6779 408 µM -0.69915415914979 0.198257072739457 no 2731 0.242227847529851 824 2893481 SGTC_1109 tnp00067 928.257 nM -0.700204682885657 0.197913580126852 no 2732 0.241899743765828 837 676295 SGTC_1426 4048-4480 71.7 µM -0.703680662767258 0.196779594668474 no 2733 0.240815832682685 838 14224343 SGTC_1672 st016598 6.51 µM -0.704898720699669 0.196383154671284 no 2734 0.240436633179053 843 4665860 YNL267W PIK1 SGTC_3241 9133421 49.47 µM -0.704953591707722 0.196365307266092 no 2735 0.240419558678643 866 17018221 SGTC_1628 st004252 77.7 µM -0.705919003790243 0.196051457100455 no 2736 0.240119254376541 835 692968 SGTC_2980 9014342 25.29 µM -0.707280763759469 0.195609274051668 no 2737 0.239696008631727 833 2996599 SGTC_1816 st051957 91.6 µM -0.707503557114991 0.195536987526705 no 2738 0.239626801472353 852 674121 SGTC_414 piperonyl butoxide 100 µM -0.708497022781677 0.195214849638166 no 2739 0.239318330192024 831 5794 A potent inhibitor of cytochrome P450. SGTC_2386 9075165 157.42 µM -0.709326940680867 0.194945990600248 no 2740 0.239060806909687 836 16452277 SGTC_2938 9059746 27.26 µM -0.709735529580877 0.194813707464891 no 2741 0.238934077561896 847 6471769 SGTC_458 nppb 133 µM -0.710605184417145 0.194532333262498 no 2742 0.238664464756357 836 4549 A chloride channel blocker. SGTC_94 0334-0113 514.748 µM -0.711745225355267 0.194163851314385 no 2743 0.238311278411986 843 6795178 SGTC_427 1354-0053 47.3 µM -0.711817363522266 0.194140549258562 no 2744 0.238288939537141 849 6813657 SGTC_1953 st076800 12.1 µM -0.712607205931244 0.193885525973062 no 2745 0.238044425742289 831 297591 SGTC_2181 6316240 54.2555 µM -0.713400785997604 0.19362950160832 no 2746 0.237798893433544 849 12779990 SGTC_1749 st037932 54.2 µM -0.713667703576695 0.193543435160068 no 2747 0.237716340820471 875 594497 SGTC_2079 5212404 121 µM -0.715103633138001 0.193080826256987 no 2748 0.23727250457427 824 758462 SGTC_465 cgp-37157 41 µM -0.715709370386578 0.19288588042888 no 2749 0.237085411814243 819 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_815 1582-0027 36.9 µM -0.718116418527953 0.192112403328827 no 2750 0.236342753743065 865 3128206 SGTC_845 0330-0138 4.51 µM -0.718174697137976 0.19209369973179 no 2751 0.236324788659418 843 9039800 SGTC_3005 9076496 71.4286 µM -0.718309376335804 0.19205048083868 no 2752 0.236283275050761 838 21368410 SGTC_726 3448-4391 34.2 µM -0.718590700516263 0.191960222400013 no 2753 0.236196572447638 844 1356692 SGTC_538 2922-0838 53.3 µM -0.718859504062138 0.191874005269557 no 2754 0.236113745009989 848 777039 SGTC_1316 1272-0050 65.9 µM -0.719873262924196 0.1915490615139 no 2755 0.235801515727862 852 7340392 SGTC_1768 st044301 37.178 µM -0.721080205647638 0.191162635740657 no 2756 0.235430084457383 877 3931349 SGTC_2611 pyromycin 23.93 µM -0.722543801863758 0.190694679196379 no 2757 0.234980102724891 848 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_944 3370-0224 231 µM -0.724003800814967 0.190228573945449 no 2758 0.234531700826476 837 4580514 SGTC_2979 9012552 45.46 µM -0.725221366571459 0.189840401327459 no 2759 0.234158118424184 858 17100905 SGTC_419 nsc-638432 893 µM -0.725367370059762 0.189793886623423 no 2760 0.234113342704555 837 368090 SGTC_946 3434-1334 87.4 µM -0.726626182983795 0.189393136898126 no 2761 0.233727492119996 835 4047976 SGTC_1741 st038134 10.228 µM -0.726949557644998 0.189290273011163 no 2762 0.233628428452115 841 1272587 SGTC_1930 st074634 34.3 µM -0.72711943945188 0.189236248227821 no 2763 0.233576395624129 855 684253 YOR116C RPO31 SGTC_1709 st033179 39.1045 µM -0.727599878157921 0.18908351341539 no 2764 0.233429277609832 848 573381 SGTC_1865 st057639 52.2 µM -0.728178124239731 0.188899785670398 no 2765 0.233252277600313 859 688818 SGTC_1844 rapamycin 4 nM -0.72916119990595 0.188587682856023 no 2766 0.232951531074913 837 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_1337 1486-1011 40.3 µM -0.730545765335136 0.188148656299639 no 2767 0.232528324686355 838 X1337 SGTC_2990 9074105 71.4286 µM -0.730656756154449 0.188113489973797 no 2768 0.232494417741565 859 6502001 SGTC_667 1498-1044 59 µM -0.731310936030218 0.187906302080982 no 2769 0.232294626082303 870 6739982 SGTC_2889 9059656 51.95 µM -0.731523905659594 0.187838882041994 no 2770 0.232229604105682 867 3949838 SGTC_1635 st007035 42.4 µM -0.731588303025628 0.187818498636063 no 2771 0.232209944874033 833 3716403 SGTC_1386 3228-0095 33.8 µM -0.731661920609863 0.187795198469791 no 2772 0.232187472028211 837 870181 SGTC_1068 loratadine 26.9 µM -0.733605262707344 0.187180771110686 no 2773 0.231594676278202 866 3957 A H1 histamine antagonist. SGTC_2259 7964009 200 µM -0.733998229459988 0.187056677912415 no 2774 0.231474908585548 835 313134 SGTC_362 0310-0100 9.03 µM -0.735597460781968 0.186552189032749 no 2775 0.230987854171404 832 790235 SGTC_2842 9000675 19.48 µM -0.73796177301425 0.185807895248869 no 2776 0.230268839540745 839 2989072 SGTC_3346 9158254 43.5805 µM -0.738514757966073 0.185634079777443 no 2777 0.230100851232712 862 17639500 SGTC_2516 gossypol 71.55 µM -0.738549943075066 0.185623023729893 no 2778 0.230090164859444 865 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_623 k072-0108 16.9 µM -0.738627794118129 0.1855985624233 no 2779 0.230066521033892 847 5382803 SGTC_1893 st059353 36.1 µM -0.741540089573645 0.184684937573355 no 2780 0.229183016828195 886 3112488 SGTC_1734 st037168 69.4 µM -0.742475864112486 0.184391967553553 no 2781 0.228899534977699 861 708907 SGTC_925 2064-1272 59.6 µM -0.743300321383968 0.184134088197633 no 2782 0.228649938528099 861 6815817 SGTC_3057 9095946 49.47 µM -0.745113874275942 0.183567623296508 no 2783 0.228101441189582 863 24540043 SGTC_2141 5621638 7.665 µM -0.745192704722835 0.183543025189348 no 2784 0.228077616222727 843 2856238 SGTC_146 3448-8650 53.125 µM -0.745618982100139 0.18341004597573 no 2785 0.227948806437563 871 2891488 YIL048W NEO1 SGTC_1392 3455-1037 33.9 µM -0.747210020510423 0.182914244783475 no 2786 0.227468398176403 828 981132 SGTC_2665 lovastatin 100 µM -0.747782261078843 0.182736127237511 no 2787 0.227295751754742 851 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_763 3453-1109 128 µM -0.748461961229013 0.182524702204804 no 2788 0.227090780477767 841 1560353 SGTC_1155 4088-0394 48.2 µM -0.749396172293801 0.182234359366848 no 2789 0.226809228670847 859 2326248 SGTC_589 1227-0070 34.1 µM -0.749561910011801 0.1821828800139 no 2790 0.226759299342301 838 2841384 SGTC_3130 9127414 49.47 µM -0.7498651535083 0.182088713888402 no 2791 0.226667961756468 853 1494646 SGTC_310 1273-0058 1.06 µM -0.752322610819585 0.181326723152779 no 2792 0.225928536777793 822 2734232 SGTC_155 k072-0202 43.6 µM -0.753548643698052 0.180947311341441 no 2793 0.225560145973052 854 5857737 SGTC_282 k297-0036 65.7 µM -0.753550197976233 0.180946830665825 no 2794 0.225559679168979 866 5061378 SGTC_1777 st045864 34.765 µM -0.753626478861187 0.180923241044952 no 2795 0.225536770024414 879 4691462 SGTC_2051 5263410 176 µM -0.754510517739572 0.180649995448321 no 2796 0.225271366117026 851 227584 SGTC_2720 fluspirilene 36.88 µM -0.754746922856116 0.180576969395852 no 2797 0.225200423159292 863 3396 An atypical antipsychotic. SGTC_1798 st045719 60.953 µM -0.755234634233104 0.180426372800662 no 2798 0.225054105542695 840 3980186 SGTC_2134 5324836 1.464 µM -0.755783960247091 0.180256845083686 no 2799 0.224889367530034 871 699272 SGTC_172 1112-0046 2.638 µM -0.758505653038254 0.179418377768555 no 2800 0.224074165052258 869 2802135 YIL048W NEO1 SGTC_1842 st055362 61.2 µM -0.758862647500767 0.179308581270909 no 2801 0.22396736259705 838 676032 SGTC_1092 toremifene 6.32 µM -0.760394549692544 0.178837912319714 no 2802 0.223509390102699 868 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_75 0159-0059 199.013 µM -0.761065378203389 0.17863204881932 no 2803 0.223309009223462 874 5377270 SGTC_2383 9036125 200 µM -0.762499228364999 0.178192530232684 no 2804 0.222881051754982 852 79580 SGTC_2297 7971671 152.32 µM -0.763373187512132 0.177924969868225 no 2805 0.222620432836751 855 909016 SGTC_640 3381-0960 37.1 µM -0.764140146323896 0.177690376228732 no 2806 0.22239186513986 869 1745025 SGTC_1046 2001-0062 216 µM -0.766434702622133 0.176989694503703 no 2807 0.221708845424778 865 739778 SGTC_747 3448-8087 38.7 µM -0.766861030858013 0.176859700520947 no 2808 0.22158207262018 876 5168703 SGTC_479 n-linoleoylglycine 10 µM -0.769028381858847 0.176199775681352 no 2809 0.220938230967866 863 6433346 An anti-infammatory. SGTC_1302 1159-0335 255 µM -0.770201829891057 0.175843130090064 no 2810 0.220590089307249 860 649284 SGTC_2735 sertaconazole 140 nM -0.770896742428515 0.175632141312164 no 2811 0.220384069080993 894 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_58 0957-0393 9 µM -0.772977089141942 0.175001467577753 no 2812 0.219767969910954 860 6997992 SGTC_1104 tacrolimus 29.8 µM -0.773117516747879 0.174958947659201 no 2813 0.219726417626696 847 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_2945 9067681 61.76 µM -0.773304450583022 0.174902356343518 no 2814 0.219671111229414 888 16456930 SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.773722579634004 0.174775816322691 no 2815 0.219547432166993 856 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_1702 st027038 51 µM -0.775655295481523 0.17419166639474 no 2816 0.218976271015163 855 5521182 SGTC_3221 9128209 49.47 µM -0.777389412201972 0.173668599065447 no 2817 0.218464528600569 879 16460723 SGTC_3208 9114115 49.47 µM -0.777753248982938 0.173558980737763 no 2818 0.218357246883893 852 650895 SGTC_1711 st032263 62.8 µM -0.778123005101681 0.173447624127107 no 2819 0.21824825087678 872 3958979 SGTC_2922 7999257 32.47 µM -0.778169722416461 0.173433557868786 no 2820 0.218234481866333 886 2988377 SGTC_1272 0839-0021 27 µM -0.778674799490344 0.173281529040864 no 2821 0.218085652286237 879 5027250 SGTC_1992 st073643 23.3 µM -0.779372608240729 0.173071627384564 no 2822 0.21788012731073 876 3161292 SGTC_1712 st032288 53.4 µM -0.779452864723613 0.173047496533724 no 2823 0.217856496606287 868 2883011 SGTC_2996 9066192 71.4286 µM -0.782258065519688 0.172205399051756 no 2824 0.217031463008102 853 6472854 SGTC_3333 9141820 12.094 µM -0.782429981915465 0.172153876388536 no 2825 0.216980959708734 859 1939433 SGTC_2673 kobusone 100 µM -0.78305187710301 0.171967579036069 no 2826 0.216798324393986 887 6710676 An epoxy ketone and protein crosslinker. SGTC_819 1013-0258 27.7 µM -0.783514171530917 0.171829175744859 no 2827 0.216662617510244 863 5753198 SGTC_2227 7312221 64.1025 µM -0.784265223652349 0.17160447489313 no 2828 0.216442250368658 892 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_1707 st032323 6.317 µM -0.784507977586405 0.171531887587751 no 2829 0.216371051380327 861 3132057 YMR211W DML1 SGTC_495 decylubiquinone 155 µM -0.786538914239677 0.170925373962382 no 2830 0.215775915214131 870 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_435 c-PAF 6.7 µM -0.787060574150929 0.170769808552095 no 2831 0.21562320373126 849 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_303 1348-1668 34.2 µM -0.787722957430578 0.170572408322384 no 2832 0.215429387020202 870 5380509 SGTC_3036 9090181 49.47 µM -0.788709992075885 0.170278528247186 no 2833 0.215140763255902 877 25236586 SGTC_752 1896-0090 130 µM -0.79045632667857 0.169759369077239 no 2834 0.214630659068557 860 772567 SGTC_3085 9117376 49.47 µM -0.791362301517891 0.169490436643581 no 2835 0.214366301076017 865 16480349 SGTC_2511 berberine 10.47 µM -0.795484206899486 0.168270330862976 no 2836 0.213165947089472 876 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1485 3909-9022 254 µM -0.796815382763853 0.167877505706145 no 2837 0.212779129927763 889 714516 SGTC_3249 9135183 49.47 µM -0.796920432284587 0.167846531126866 no 2838 0.212748621770453 843 4902779 SGTC_1743 st037606 46.3785 µM -0.797608983533859 0.167643598120471 no 2839 0.212548718079791 853 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_680 0417-1641 114 µM -0.798552510760328 0.167365774163001 no 2840 0.212274966723633 868 2835990 SGTC_3145 9085516 49.47 µM -0.800858508020178 0.166688016991479 no 2841 0.211606781478203 882 25236195 SGTC_2773 thioridazine 9.09 µM -0.801240261187768 0.166575986776075 no 2842 0.211496283674148 879 5452 An antipsychotic. SGTC_2821 7996764 71.43 µM -0.801504805651494 0.166498381427268 no 2843 0.211419731552384 826 2987135 SGTC_707 0865-0008 204 µM -0.801675976943209 0.166448179971548 no 2844 0.211370207787664 886 723043 SGTC_1706 st031321 9.9705 µM -0.802698431583412 0.16614851599882 no 2845 0.211074529847735 868 6103185 SGTC_3172 9105863 49.47 µM -0.803049791543344 0.166045618913669 no 2846 0.210972978021619 878 2348785 SGTC_2537 larixol 68.93 µM -0.804122228810694 0.165731806324604 no 2847 0.210663193994163 871 6708759 SGTC_1206 3978-0017 132 µM -0.804260865764924 0.165691266903794 no 2848 0.210623166838298 872 3873677 SGTC_2448 5185112 27.17 µM -0.805691174282159 0.165273398667188 no 2849 0.210210469830392 859 5718189 SGTC_2306 7482397 179.52 µM -0.806981313781669 0.164897066691926 no 2850 0.209838624494541 916 891448 SGTC_2148 5546263 113.568 µM -0.80860329690017 0.16442472444855 no 2851 0.209371683896177 887 792097 SGTC_320 4092-0846 5.34 µM -0.809124010951599 0.164273272018305 no 2852 0.209221909175499 855 1359356 SGTC_1514 1189-1591 158 µM -0.810715618053965 0.163810905695926 no 2853 0.208764501108318 889 767698 YMR146C TIF34 SGTC_1556 plumbagin 1.48 µM -0.811587130016582 0.163558087250411 no 2854 0.208514289305237 851 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_636 0kpi-0074 126 µM -0.81249302061106 0.163295564553373 no 2855 0.20825439488948 881 616434 SGTC_301 4119-0100 24.5 µM -0.813263331599358 0.163072547657621 no 2856 0.208033547855478 893 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_2371 9071574 200 µM -0.814384852171463 0.162748204290409 no 2857 0.20771225683444 889 45596039 SGTC_3078 9116413 49.47 µM -0.814391643814273 0.162746241428613 no 2858 0.207710312071252 877 17177322 SGTC_2256 7954252 200 µM -0.815358466448124 0.162466975834588 no 2859 0.2074335755586 909 2972920 SGTC_2865 9030313 51.95 µM -0.817233066386943 0.161926388888936 no 2860 0.206897624644621 886 42562754 SGTC_1613 st002381 52.1 µM -0.81725795409018 0.161919219799187 no 2861 0.206890514730321 876 551167 SGTC_1417 3966-0327 90.4 µM -0.821225768368172 0.160778905642686 no 2862 0.205758840652878 902 651118 SGTC_2426 5582046 32.21 µM -0.821527606144683 0.160692375314874 no 2863 0.205672903062155 880 2251934 SGTC_2377 9073351 62.6 µM -0.821932132603117 0.1605764540768 no 2864 0.205557761929079 904 7337946 YHR072W ERG7 SGTC_76 0433-0009 400.328 µM -0.823033465365786 0.16026113265591 no 2865 0.205244481477453 919 2841569 SGTC_2075 5212009 200 µM -0.823362025046134 0.160167141511878 no 2866 0.205151075746905 870 780898 SGTC_571 k831-0106 44.2 µM -0.823489588344768 0.160130659163084 no 2867 0.205114817779839 870 4783639 SGTC_1030 k029-0042 36.7 µM -0.824803775684775 0.159755125677715 no 2868 0.204741501375841 892 6080581 SGTC_535 2293-4129 48.2 µM -0.825497154153091 0.15955722282374 no 2869 0.204544698854552 921 396118 YIL048W NEO1 SGTC_2423 st077119 87.2 µM -0.82660216968672 0.159242163020201 no 2870 0.204231293598737 865 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_356 1634-0012 32.5 µM -0.828820009700375 0.158611047302014 no 2871 0.203603131901714 883 735457 SGTC_97 0535-0701 19.132 µM -0.829407824704192 0.158444052104439 no 2872 0.203436837653718 864 2832013 YGL099W LSG1 SGTC_2603 homopterocarpin 100 µM -0.830825636445829 0.158041733878287 no 2873 0.203036068941843 886 101795 A weak amylase inhibitor. SGTC_3273 9137859 49.47 µM -0.830972158689048 0.158000194996964 no 2874 0.202994678821002 922 2377234 SGTC_1688 st021091 57.6 µM -0.831020516344215 0.157986487232695 no 2875 0.20298101968574 897 3656366 SGTC_2301 7769476 200 µM -0.831043686052797 0.157979919678445 no 2876 0.20297447534903 872 977820 SGTC_213 1246-0773 967 nM -0.831495587635079 0.157851862059607 no 2877 0.202846859920428 889 6251622 SGTC_821 1114-0266 29.2 µM -0.831501104252638 0.157850299209293 no 2878 0.202845302343086 872 3123235 SGTC_3008 9078912 71.4286 µM -0.831989229038084 0.157712054344 no 2879 0.202707512102414 900 16648731 SGTC_2152 5568786 200 µM -0.832242537421645 0.157640344651683 no 2880 0.20263602902814 884 5399883 SGTC_1288 0973-0013 65.5 µM -0.832412746449692 0.157592171794774 no 2881 0.202588004875078 879 4315430 SGTC_1056 3448-1962 115 µM -0.832627192107185 0.15753149278082 no 2882 0.202527509127304 888 715507 SGTC_3070 9117005 49.47 µM -0.834484648813706 0.157006553908388 no 2883 0.202003967180043 891 8779016 SGTC_1545 lovastatin 49.4 µM -0.836128992176539 0.156542804640119 no 2884 0.201541169907214 866 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_2546 rhodinyl acetate 100 µM -0.836552240834635 0.156423583170703 no 2885 0.201422150269574 879 6708682 SGTC_1660 st012960 28.1 µM -0.837259553281418 0.156224479578213 no 2886 0.201223344518694 872 24207266 SGTC_1451 4152-0210 104 µM -0.837506786560464 0.1561549245055 no 2887 0.2011538819158 887 659563 SGTC_3331 9141060 1.957 µM -0.838569454311098 0.155856192540642 no 2888 0.200855478809412 882 4906567 YPR165W RHO1 SGTC_1604 st002052 72.4 µM -0.840787677839126 0.155233831242636 no 2889 0.200233445712938 878 6254834 YHR062C RPP1 SGTC_1572 epiandrosterone 68.9 µM -0.842509341658877 0.154751920672407 no 2890 0.199751456485976 877 441302 A steroid. SGTC_1641 st009299 47.1 µM -0.842588652794866 0.154729744549675 no 2891 0.199729269728346 858 4046054 SGTC_816 0325-0417 81.3 µM -0.843267588795577 0.154539993726146 no 2892 0.199539402615626 872 68101 SGTC_1037 k284-1091 78.7 µM -0.845344998057262 0.153960349588931 no 2893 0.198959122058545 878 3334711 SGTC_1591 genipin 88.4 µM -0.846635784757007 0.153600916502645 no 2894 0.198599080763935 908 442424 A DNA cross-linking agent. SGTC_2157 5649910 96.377 µM -0.847024946040273 0.153492659566048 no 2895 0.198490608501042 899 2858091 SGTC_2457 5731572 11.68 µM -0.847553573524097 0.153345686865966 no 2896 0.198343319608575 880 2865357 SGTC_246 cycloheximide 667 µM -0.847706807477769 0.153303101128892 no 2897 0.198300637114598 874 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_2166 5933061 31.504 µM -0.848417442155636 0.153105708817062 no 2898 0.198102766123082 897 2877375 SGTC_2149 5554786 194.827 µM -0.850525785922695 0.152521067898934 no 2899 0.1975164152456 896 745063 YPR165W RHO1 SGTC_2563 tomatine 8.54 µM -0.850758125821972 0.152456731092697 no 2900 0.197451863511577 896 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_2253 7938677 135.83 µM -0.851919137301299 0.152135507471902 no 2901 0.19712948718228 892 2301972 SGTC_2942 9052777 62.25 µM -0.852237960929605 0.152047375445488 no 2902 0.197041015670512 901 6469503 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.852651767401483 0.151933038003465 no 2903 0.19692622287249 906 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2069 5228469 200 µM -0.854738159125889 0.151357424458696 no 2904 0.196348060195165 902 2835210 SGTC_248 streptozotocin 5.23457 mM -0.857238684924979 0.150669468771593 no 2905 0.195656493486321 895 5300 DNA alkylating agent. SGTC_1384 3089-0840 101 µM -0.857491927492234 0.150599911864214 no 2906 0.195586537125892 883 1069836 SGTC_3324 9138759 60.749 µM -0.858084028450443 0.150437365835492 no 2907 0.195423032952848 895 45595710 SGTC_523 1934-0222 13.7 µM -0.858266460926886 0.150387307272681 no 2908 0.195372672348805 916 1361595 SGTC_485 niflumic acid 177 µM -0.858404707982766 0.150349380361842 no 2909 0.195334514410275 902 4488 A COX2 inhibitor. SGTC_1427 4048-4900 550 nM -0.858506829238558 0.15032136835199 no 2910 0.195306330557907 884 24132586 SGTC_174 3553-0389 74.3 µM -0.858691949499398 0.150270598460401 no 2911 0.195255246591288 886 738071 SGTC_3056 9094900 49.47 µM -0.85938455832163 0.150080749389369 no 2912 0.195064193095699 893 25236784 SGTC_2159 5658611 73.75 µM -0.859912530847189 0.149936135765848 no 2913 0.194918630253125 905 793844 SGTC_663 1486-0733 13.9 µM -0.861818139384643 0.149414955726677 no 2914 0.194393800702815 888 722445 YPR165W RHO1 SGTC_49 0717-0965 32.132 µM -0.862438292930788 0.149245606125698 no 2915 0.194223188009783 903 5889349 YGL099W LSG1 SGTC_131 0141-0277 33.849 µM -0.86417516659119 0.148771988464716 no 2916 0.193745835988327 906 1547771 SGTC_3092 9117248 49.47 µM -0.864239667554439 0.148754419449925 no 2917 0.193728122712685 918 17141857 SGTC_3218 9131285 49.47 µM -0.864737147390166 0.148618960617098 no 2918 0.193591537814579 888 17156417 SGTC_2132 5317594 122.667 µM -0.865710400766703 0.148354191908932 no 2919 0.193324497450557 905 794577 SGTC_1564 D-Arginine 115 µM -0.865802249190626 0.148329221307683 no 2920 0.193299307777484 903 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_1477 0139-0234 16 µM -0.86612261141357 0.148242147237209 no 2921 0.193211463268985 888 620880 SGTC_1722 st034304 3.6505 µM -0.866858270141966 0.148042325522682 no 2922 0.19300983516198 909 4036148 YLR033W RSC58 SGTC_318 1488-0629 67.2 µM -0.867358748898111 0.147906487143538 no 2923 0.192872738254018 914 3662576 SGTC_856 0433-0016 11.3 µM -0.869031352233538 0.147453119939233 no 2924 0.192414991226305 884 3911780 SGTC_3023 9089636 49.47 µM -0.870025693900171 0.147184040597589 no 2925 0.192143181467037 916 17249241 SGTC_1468 k284-1086 134 µM -0.871881795146756 0.146682641242763 no 2926 0.191636433039441 888 15996457 SGTC_775 4577-0580 57.3 µM -0.874026191388082 0.146104791677334 no 2927 0.191051995213914 903 2006902 SGTC_260 nsc-65238 3.989 µM -0.874243411778836 0.146046342801777 no 2928 0.190992854587619 907 3246252 SGTC_223 busulfan 5 mM -0.875193056589576 0.145791000292604 no 2929 0.190734435278551 878 2478 A DNA alkylator. SGTC_1826 st055655 41.6 µM -0.876563106200473 0.145423147475976 no 2930 0.190361992849738 893 676168 SGTC_1410 3909-8106 77.9 µM -0.87687576719905 0.145339286821822 no 2931 0.190277059866547 886 1039210 SGTC_1042 0350-0096 82 µM -0.879009881768286 0.144767752305954 no 2932 0.189697958959962 899 3122515 SGTC_2653 dihydrofissinolide 100 µM -0.879026275311837 0.144763367838052 no 2933 0.189693514703201 908 6857746 SGTC_2969 9091408 28.7 µM -0.879808236798678 0.144554335402822 no 2934 0.189481600901622 891 4286311 SGTC_418 lividomycin a 100 µM -0.88042649073175 0.144389208973904 no 2935 0.189314155482159 886 72394 An antibiotic. SGTC_2797 7859098 81.82 µM -0.880810976113459 0.144286582782036 no 2936 0.189210068953678 880 972681 SGTC_2258 7960471 200 µM -0.881772674412124 0.14403010322921 no 2937 0.188949875709918 901 2974708 SGTC_1431 4049-0260 9.09 µM -0.882043438296219 0.143957947519736 no 2938 0.188876658703589 902 3854841 SGTC_850 0388-0143 75.9 µM -0.883548407168205 0.143557333668161 no 2939 0.188470020189392 892 67273 SGTC_3280 9140961 49.47 µM -0.883880360776894 0.14346907096744 no 2940 0.188380399954005 920 4901226 SGTC_586 0957-0265 8.15 µM -0.885707689668943 0.14298386092372 no 2941 0.187887531771124 879 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_1602 st001878 87.6 µM -0.887862032162639 0.142413244858209 no 2942 0.18730748509327 900 595405 YLR310C CDC25 SGTC_2722 naftopidil 47.16 µM -0.888126365108337 0.142343337804532 no 2943 0.187236391012278 908 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_2854 9024559 71.43 µM -0.888969976608237 0.142120386618056 no 2944 0.187009607785065 916 3163529 SGTC_3329 9141233 27.5565 µM -0.890360177483377 0.141753497703362 no 2945 0.186636259021584 890 4909101 YNL103W MET4 SGTC_1999 st074831 12.5 µM -0.890588961125166 0.141693180773622 no 2946 0.186574861728455 908 17112523 SGTC_1389 3405-0187 19 µM -0.894009152430016 0.140793547886757 no 2947 0.185658497119963 885 799890 SGTC_3000 9075062 71.4286 µM -0.894946284606487 0.140547726458115 no 2948 0.185407901490811 869 17057871 SGTC_2339 9000433 200 µM -0.895732325041847 0.140341763075653 no 2949 0.185197870843029 904 2988954 SGTC_218 alverine citrate 93.75 µM -0.89739103495283 0.139907810103934 no 2950 0.184755147335613 890 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1358 1509-0022 2.48 µM -0.899614615643412 0.139327507255007 no 2951 0.18416268822278 908 3258434 SGTC_3120 9124077 49.47 µM -0.899650884645028 0.139318055482478 no 2952 0.184153034386767 929 18774327 YGL155W CDC43 SGTC_3268 9137683 49.47 µM -0.902295701091348 0.138629986832052 no 2953 0.183449904299841 951 1953228 SGTC_271 rotenone 740 µM -0.902486329853828 0.13858048294342 no 2954 0.183399289977884 911 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_2250 alverine citrate 130 µM -0.904674635729077 0.138013070147579 no 2955 0.182818891129846 874 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_1111 tnp00062 510.699 nM -0.908347650404026 0.137064248639465 no 2956 0.181847287258602 889 676306 SGTC_2838 9002687 71.43 µM -0.90839234107076 0.137052731555309 no 2957 0.18183548538706 913 6457060 SGTC_2417 cerulenin 830 nM -0.908798436816066 0.13694810826449 no 2958 0.181728265940907 897 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_947 3447-0010 211 µM -0.914063748468159 0.135596536147272 no 2959 0.180341674839513 910 748350 SGTC_2155 5570423 76 µM -0.915118508178773 0.135326888490949 no 2960 0.180064709810068 926 797402 SGTC_2923 7992654 58.14 µM -0.917014278045635 0.134843162425038 no 2961 0.179567579133812 876 2985126 SGTC_1900 st060200 72.8 µM -0.918060282841137 0.134576771490116 no 2962 0.179293653308744 910 688945 SGTC_221 trifluoperazine 10.304 µM -0.9208671859202 0.133863710485802 no 2963 0.178559886202667 922 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_1225 1216-0074 20.6 µM -0.921419712002911 0.133723654129302 no 2964 0.178415670591589 913 4241466 SGTC_280 3448-3607 3.04 µM -0.925304526178316 0.132741761409527 no 2965 0.177403762524445 894 626179 SGTC_838 0109-0203 71.4 µM -0.926370483851711 0.13247320935237 no 2966 0.177126738892864 893 759422 SGTC_1590 st077108 57.8 µM -0.930500859843878 0.131436160115199 no 2967 0.17605590957423 890 5489485 SGTC_1725 st036284 20.55 µM -0.931370230033405 0.131218595768541 no 2968 0.175831042376062 902 707914 SGTC_3063 1327-0034 4 µM -0.93182308858866 0.131105364173684 no 2969 0.175713980209184 891 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2697 mebhydrolin 72.4 µM -0.932451560472766 0.130948334534812 no 2970 0.175551604513265 919 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_1747 st037496 66.6 µM -0.932528399998709 0.13092914437317 no 2971 0.175531758327146 921 723305 SGTC_3081 9117243 49.47 µM -0.933459967848618 0.130696646076621 no 2972 0.175291265223205 912 45595589 SGTC_98 0074-0023 107.663 µM -0.933844999545448 0.13060063427305 no 2973 0.175191926679867 909 3563821 SGTC_3288 9119690 36.221 µM -0.934332774910226 0.130479072268545 no 2974 0.175066131450309 942 17595618 YKL019W RAM2 SGTC_1645 Cervolide 78 µM -0.934710471283331 0.130384997612513 no 2975 0.174968764507082 911 23173 A fragrance. SGTC_2372 9071633 200 µM -0.935986244526333 0.13006758155268 no 2976 0.174640135024998 924 21321366 SGTC_2317 5986382 200 µM -0.936394309320266 0.129966166840486 no 2977 0.174535103418504 947 877883 SGTC_1563 conessine 56.1 µM -0.937420954933518 0.129711260848845 no 2978 0.174271033057557 918 441082 An anti-amoebic, histamine inhibitor. SGTC_3029 9088683 49.47 µM -0.938277709341068 0.129498802377152 no 2979 0.174050855988174 903 25236615 SGTC_582 0987-0078 156 µM -0.940417991561544 0.128969107770628 no 2980 0.173501598562783 924 1625765 SGTC_3080 9117754 49.47 µM -0.941275499134563 0.128757306941346 no 2981 0.173281847543557 906 9550191 SGTC_2104 5389443 200 µM -0.94365823542342 0.128170048238241 no 2982 0.172672161373255 927 2244536 SGTC_2026 5148700 152 µM -0.944333064433909 0.128004065744135 no 2983 0.172499737312476 926 79838 SGTC_810 3825-7150 143 µM -0.944390285053548 0.127989998500106 no 2984 0.172485122050887 877 22330411 YGL099W LSG1 SGTC_1474 0330-0125 5.35 µM -0.946959851501764 0.127359397392248 no 2985 0.171829618816906 941 X1474 SGTC_721 1187-1332 279 µM -0.947993792765937 0.1271062670622 no 2986 0.171566307104936 940 25730 SGTC_2905 7799065 20.05 µM -0.948432678824598 0.126998924538285 no 2987 0.171454614876578 895 1296806 SGTC_1466 k213-0079 57.5 µM -0.951576948342732 0.126231745852672 no 2988 0.170655788414571 935 3657981 SGTC_2036 5160441 105 µM -0.951618540202794 0.126221619436551 no 2989 0.170645237666023 899 134534 YIL048W NEO1 SGTC_2353 9059630 146.67 µM -0.951631987436108 0.126218345544924 no 2990 0.17064182654996 931 4779114 SGTC_1926 methyl fluorone black 53.6 µM -0.952231923952557 0.126072343961501 no 2991 0.170489687016211 857 72721 Reacts with homocysteine. SGTC_417 st075190 100 µM -0.955740951254549 0.125220739477729 no 2992 0.169601563777925 921 222757 SGTC_2280 7785178 200 µM -0.957611387167208 0.124768448883434 no 2993 0.169129377483579 903 2954328 SGTC_2587 piperic acid 92.2 µM -0.958114654086814 0.12464694892951 no 2994 0.169002473423641 906 5370536 SGTC_170 4197-0004 226 µM -0.963295156095796 0.123401065263544 no 2995 0.167699711734006 928 218692 SGTC_812 4251-0442 148 µM -0.963386801936841 0.123379103730158 no 2996 0.167676723554704 943 5723007 SGTC_3316 9136639 10.545 µM -0.965060108431605 0.12297860259812 no 2997 0.167257353000051 904 4903665 SGTC_2636 apigenin dimethyl ether 100 µM -0.968841329156105 0.12207693757385 no 2998 0.166312181151529 931 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_1904 st060225 78 µM -0.970632135500411 0.12165152809033 no 2999 0.165865748718573 910 66595 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.975589550101779 0.120479322088256 no 3000 0.164633952540693 948 442882 SGTC_1029 k015-0030 64.7 µM -0.976585451415947 0.120244798864835 no 3001 0.164387212274177 909 2208316 SGTC_2939 9044578 71.43 µM -0.980779395495748 0.119260703437378 no 3002 0.163350770587056 932 2653634 SGTC_2162 5663267 200 µM -0.981091150356823 0.119187778805435 no 3003 0.163273897054356 942 6456493 SGTC_520 3584-0023 682 µM -0.983875072676513 0.118537968531613 no 3004 0.162588470712155 916 1340790 SGTC_750 4073-0104 132 µM -0.984169289224514 0.118469440428798 no 3005 0.162516141528499 884 22330957 SGTC_1958 st076513 41.9 µM -0.984184346105148 0.118465934175203 no 3006 0.162512440560028 937 732122 YGL099W LSG1 SGTC_2569 tetrandrine 100 µM -0.984892837940543 0.118301032582917 no 3007 0.16233835587405 921 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1093 fluphenazine 7.97 µM -0.988028952618703 0.117573050569016 no 3008 0.161569234449821 949 6602611 An atypical antipsychotic. SGTC_553 k007-0256 45.7 µM -0.989680703161755 0.117190909525174 no 3009 0.161165104910424 928 6287000 SGTC_3083 9117465 49.47 µM -0.991818308902326 0.116697670672256 no 3010 0.160643082332174 938 16420915 SGTC_2951 9072950 58.06 µM -0.993791447752475 0.116243689537407 no 3011 0.160162205303423 922 16488155 SGTC_847 0342-0274 5.54 µM -0.993840190613396 0.116232490630592 no 3012 0.160150338020617 934 18097 SGTC_2370 9071495 200 µM -0.994335407506242 0.116118755567943 no 3013 0.160029801591385 955 21791103 SGTC_2352 9027995 87.8 µM -0.995928733922004 0.115753356788627 no 3014 0.159642386485997 932 2997347 SGTC_96 0929-0093 37.281 µM -0.997733684484786 0.115340413483755 no 3015 0.159204257341456 938 6991579 SGTC_2571 chrysanthemic acid 100 µM -0.998287201815449 0.115213987763066 no 3016 0.159070055881004 958 2743 An insecticide. SGTC_1077 5-fluorocytosine 377 nM -0.998952500661698 0.115062161072392 no 3017 0.158908850857032 941 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_3163 9099914 49.47 µM -1.00094244483579 0.114608888726078 no 3018 0.158427317331178 951 16268368 SGTC_2916 7875993 68.79 µM -1.00213315243893 0.114338276078515 no 3019 0.158139644014335 907 1299250 SGTC_866 0495-0101 262 µM -1.00323483635857 0.114088301367382 no 3020 0.157873784242812 919 635694 SGTC_156 3474-0145 5.642 µM -1.00335692683943 0.114060622726322 no 3021 0.157844339288347 888 2265471 SGTC_3224 9130643 49.47 µM -1.00481333059821 0.113730816129259 no 3022 0.157493371835641 934 17644395 SGTC_1299 1079-1439 3.74 µM -1.00643324183291 0.113364781954091 no 3023 0.157103604882498 940 323161 SGTC_2118 5526350 200 µM -1.00699828532183 0.113237302938201 no 3024 0.156967799092236 936 743594 SGTC_3109 9122853 49.47 µM -1.00847433719906 0.112904774641522 no 3025 0.156613400805872 960 1234709 SGTC_2833 9001315 45.46 µM -1.01278795703963 0.111936989355397 no 3026 0.15558072712314 926 2989378 SGTC_2465 5809242 33.21 µM -1.01279815368884 0.111934708728169 no 3027 0.155578291395011 973 2731748 SGTC_3147 9097027 49.47 µM -1.01589102316164 0.111244476776802 no 3028 0.15484064204424 944 25236841 SGTC_178 4092-0806 87.505 µM -1.0178158048366 0.110816466808441 no 3029 0.154382749808196 907 2169044 SGTC_836 0330-0104 1.35 µM -1.01801717324673 0.110771757173596 no 3030 0.154334897440701 906 46494820 SGTC_2496 diffractaic acid 79.83 µM -1.01846261840921 0.110672901334524 no 3031 0.154229078516444 935 94870 An apoptosis inducer which activates caspases. SGTC_2135 5326629 150.42 µM -1.01898214655784 0.110557684449984 no 3032 0.154105721242145 942 5020077 SGTC_1055 3448-0672 86 µM -1.01960811824046 0.110418975591179 no 3033 0.153957176631931 930 748378 SGTC_377 3970-0964 33.1 µM -1.02028697510646 0.110268689003751 no 3034 0.153796189365278 923 16481235 SGTC_2290 7904846 200 µM -1.02032606271422 0.11026004018556 no 3035 0.153786923342453 932 2962154 SGTC_983 1491-0821 12.2 µM -1.02190506827603 0.109911064233534 no 3036 0.15341291671834 926 46495113 SGTC_1940 st075990 51.1 µM -1.02262474272137 0.109752272246151 no 3037 0.153242653148068 966 1084979 SGTC_2287 7945887 168.79 µM -1.02461981987622 0.109312931270706 no 3038 0.152771304433824 911 1245853 SGTC_2093 5331342 194.4 µM -1.02480054291727 0.109273196289313 no 3039 0.152728655098543 926 33839 SGTC_897 1000-0139 31.4 µM -1.02535445518645 0.109151474063362 no 3040 0.152597984996326 942 6151020 SGTC_1476 4112-3294 3.34 µM -1.02664563691669 0.108868115209294 no 3041 0.152293678145156 898 704369 SGTC_3339 9145883 14.936 µM -1.02765983226602 0.108645914092708 no 3042 0.152054934367497 902 2030670 SGTC_2236 dapsone 200 µM -1.0285805855941 0.108444467940508 no 3043 0.151838402429397 923 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_1145 3546-0597 10.2 µM -1.0298143302859 0.108174965755472 no 3044 0.151548586192839 936 875334 SGTC_220 paclitaxel 373.376 µM -1.03228629478806 0.107636435246778 no 3045 0.150969009748799 930 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2468 5987765 72.9 µM -1.03432749366879 0.107193207526688 no 3046 0.150491543960137 926 26772094 SGTC_1052 3253-3998 198 µM -1.03700393297546 0.106614039365946 no 3047 0.149867012111561 941 5450317 SGTC_2662 daunorubicin 22.37 µM -1.03712537049166 0.106587814563212 no 3048 0.149838716413491 898 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1815 st051655 58.2 µM -1.0379860306182 0.106402085816607 no 3049 0.149638279362545 942 5984156 SGTC_3258 9138477 49.47 µM -1.03833865880454 0.106326056880446 no 3050 0.149556208328134 960 4970355 SGTC_2618 avocadyne 43.43 µM -1.03926163667756 0.106127242587453 no 3051 0.149341535775223 947 3015189 SGTC_1740 st038286 13.222 µM -1.04028044800567 0.10590809726281 no 3052 0.149104812599822 922 716786 SGTC_2214 7179297 48.276 µM -1.04204320265416 0.105529703236486 no 3053 0.148695824724843 941 769744 SGTC_456 gingerol 170 µM -1.04221091377112 0.105493753262702 no 3054 0.148656952109711 942 442793 A herb. SGTC_1350 1495-0454 146 µM -1.04452073209741 0.104999529397807 no 3055 0.148122266183845 929 1069057 SGTC_877 0771-0151 33.1 µM -1.04522342132714 0.104849510426204 no 3056 0.147959860508887 951 6166523 SGTC_1309 pyrazolanthrone 13.4 µM -1.0469929644984 0.104472413637683 no 3057 0.147551411533035 947 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_1252 0493-0875 34.8 µM -1.04869507311044 0.104110615549616 no 3058 0.147159241283239 927 3960963 SGTC_25 0118-0223 35.662 µM -1.0491998014795 0.104003505938585 no 3059 0.147043085005503 941 5333628 SGTC_1947 st076332 61.6 µM -1.04967449352487 0.103902843343111 no 3060 0.146933897288787 944 24208416 SGTC_541 4513-1321 94 µM -1.05089461063778 0.103644431119668 no 3061 0.146653497954689 911 747515 SGTC_2305 7443522 69.23 µM -1.05332600132139 0.10313087085314 no 3062 0.146095803011788 910 5415886 SGTC_1028 k015-0029 4.8 µM -1.05517161680682 0.10274227414396 no 3063 0.145673421355463 949 4588309 SGTC_3304 9125678 46.087 µM -1.0588909328292 0.101962402523936 no 3064 0.144824727063054 946 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_2786 7743617 45.45 µM -1.06038048803722 0.101651281553274 no 3065 0.144485767643121 938 583674 SGTC_1718 roemerine 11.9335 µM -1.06976889232847 0.099706238183643 no 3066 0.142361673864637 887 235224 An aporphine alkaloid with mutagenic activity. SGTC_753 1322-0200 289 µM -1.07007152659354 0.0996439954542812 no 3067 0.142293557201432 954 5403907 SGTC_859 0439-0102 54.6 µM -1.07127209497807 0.0993973545117287 no 3068 0.14202355157706 939 610143 SGTC_2232 chlorophetanol 41.5365 µM -1.07158357695196 0.0993334376205729 no 3069 0.14195355655463 953 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_1336 1486-0901 104 µM -1.0720437771997 0.0992390583642412 no 3070 0.141850184888265 937 5006114 SGTC_215 1287-0124 461.5 µM -1.07319377241094 0.0990035005561458 no 3071 0.141592092138827 959 5560863 SGTC_714 4296-0578 26.1 µM -1.0755883039745 0.0985143327031316 no 3072 0.141055710267677 945 1589775 SGTC_1819 st053448 58.6 µM -1.07647101385817 0.0983344550708579 no 3073 0.140858328818352 964 2857616 SGTC_2964 9083345 53.42 µM -1.07667768279291 0.098292375079585 no 3074 0.14081214296867 921 17741579 SGTC_1651 st011928 86.1 µM -1.07670270674494 0.098287280832314 no 3075 0.14080655137675 962 720198 SGTC_889 0919-1524 82.7 µM -1.07820872291812 0.0979810497369598 no 3076 0.140470310021682 941 3905452 SGTC_1024 4507-0395 26 µM -1.07929633556941 0.0977603313922675 no 3077 0.140227822970884 953 4201836 SGTC_2001 4023502 57.655 µM -1.07966167613412 0.0976862716167907 no 3078 0.14014643284368 936 108941 YCR052W RSC6 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -1.08024658063713 0.0975677887411545 no 3079 0.140016195357497 943 2374 Ca(2+)-ATPase inhibitor. SGTC_1154 4088-0362 150 µM -1.09957437008549 0.0937116657564047 no 3080 0.135758807056909 949 6618304 SGTC_599 1935-0052 86.5 µM -1.0997148129985 0.09368406357156 no 3081 0.135728199300747 952 9557311 SGTC_1406 3909-7906 11.9 µM -1.10630215856503 0.0923961430831053 no 3082 0.134297878909793 944 X1406 SGTC_2039 Aminomethylbenzodioxan 200 µM -1.10632712313298 0.0923912871991885 no 3083 0.134292478078084 956 15053 SGTC_29 0299-0004 12.984 µM -1.10852290108958 0.0919649225914958 no 3084 0.133818027186124 962 16871 A napthoquinone isolated from Swertia calycina. SGTC_3300 9124615 50.48 µM -1.10934550862634 0.0918055687350491 no 3085 0.133640579976199 960 24824903 SGTC_385 1494-0393 12.4 µM -1.10975881581364 0.0917255809503263 no 3086 0.133551485300208 970 3090647 SGTC_2413 inermin 26.06 µM -1.11016454024091 0.0916471108950665 no 3087 0.133464064942295 942 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_40 0327-0103 19.753 µM -1.11047835124296 0.0915864516870543 no 3088 0.133396475924465 931 409036 SGTC_3123 9126162 49.47 µM -1.11225168704239 0.0912442274741715 no 3089 0.133014975074361 938 25239884 SGTC_1412 3909-8563 178 µM -1.11501095451604 0.0907136217353761 no 3090 0.132422863729899 965 23767530 SGTC_919 tnp00227 403.569 nM -1.1163165951 0.0904633473343417 no 3091 0.132143320283663 969 1269246 A methoxyflavone. YNL221C POP1 SGTC_1786 berberine 21.6 µM -1.11822008915772 0.0900993912384366 no 3092 0.131736503189569 924 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_3134 9127454 49.47 µM -1.12244031273165 0.0892963483100293 no 3093 0.130837636117282 972 24262820 SGTC_195 4234-0266 16.654 µM -1.12352692271998 0.0890904479730689 no 3094 0.130606886456536 960 2303354 SGTC_1352 1496-0991 99 µM -1.12374021151224 0.0890500736713352 no 3095 0.130561626062315 974 3000039 SGTC_1353 1498-1206 8.11 µM -1.12823183854 0.088202995631147 no 3096 0.129611010524087 892 6756808 SGTC_1232 0279-0259 161 µM -1.12929307917688 0.0880037358084377 no 3097 0.129387109734469 943 1560000 SGTC_1278 0874-0585 172 µM -1.13055948095825 0.0877663941746076 no 3098 0.129120274944879 969 766306 SGTC_1143 3454-2408 5.08 µM -1.13078454916485 0.0877242632222953 no 3099 0.129072892331206 921 X1143 SGTC_2016 5121758 140 µM -1.13218821196804 0.0874618492836833 no 3100 0.128777657475049 945 2795203 SGTC_2294 7971431 200 µM -1.13360263256979 0.0871980172508041 no 3101 0.128480634132837 993 5741572 SGTC_429 1112-0049 25.5 µM -1.1340006215289 0.0871238875669747 no 3102 0.128397143648285 964 2836170 SGTC_2464 5717415 7.67 µM -1.1360238330395 0.0867477704802714 no 3103 0.127973294960733 952 5285744 SGTC_1539 benzyladenosine 56 µM -1.13641224731311 0.0866757029084395 no 3104 0.127892036232753 940 92208 A nucleotide analog. SGTC_1478 0453-0656 35.7 µM -1.13676093515323 0.0866110444247026 no 3105 0.127819119072217 995 5258496 SGTC_1396 3511-0007 98.6 µM -1.13824726326065 0.0863358334187118 no 3106 0.127508624100849 953 X1396 SGTC_1124 fisetin 1.16336 µM -1.13863333027214 0.0862644557109663 no 3107 0.127428060312435 956 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_2153 5569715 200 µM -1.13898531110273 0.0861994184713715 no 3108 0.127354640424668 968 2054701 SGTC_2332 7982454 138.89 µM -1.13925475223726 0.0861496572891397 no 3109 0.12729845742657 968 2981748 SGTC_1880 MG-132 525 µM -1.14051440810657 0.0859173053690754 no 3110 0.127036026764781 951 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_638 3970-0837 4.09 µM -1.14187044902599 0.0856676991033323 no 3111 0.126753936796911 947 4118451 YLR208W SEC13 SGTC_411 enrofloxacin 100 µM -1.1456032848335 0.084983401152893 no 3112 0.125979668748668 960 71188 A bacterial gyrase inhibitor. SGTC_2768 sulfasalazine 50.2 µM -1.14569896652683 0.0849659149404634 no 3113 0.125959865812779 984 5384001 An antioxidant and salicylic acid derivative. SGTC_3121 9125696 49.47 µM -1.15034386093859 0.0841202817732224 no 3114 0.125001136199284 989 1235365 SGTC_3037 9091026 49.47 µM -1.15223936260025 0.0837770144294558 no 3115 0.124611363346984 956 25236398 YIL048W NEO1 SGTC_225 nsc-122657 1.016 µM -1.15640823276721 0.0830257530769539 no 3116 0.12375710784858 971 275685 SGTC_701 4424-0219 185 µM -1.15810701763628 0.0827210766753676 no 3117 0.12341018327344 977 2911779 SGTC_113 0099-0221 2.5 µM -1.16213613001166 0.0820018221822086 no 3118 0.122590086750561 948 89219 SGTC_63 0099-0242 26.702 µM -1.16443414541738 0.0815937090990792 no 3119 0.122124058362405 962 3898502 YLR359W ADE13 SGTC_313 3474-0040 5.03 µM -1.16596705185338 0.0813223272922733 no 3120 0.121813883525652 967 1043375 YIL048W NEO1 SGTC_1387 3342-1166 1.8 µM -1.16793727973229 0.0809745239128256 no 3121 0.121416032615975 942 3418228 SGTC_2087 5276107 200 µM -1.17137715350732 0.0803699778467121 no 3122 0.120723605695514 962 144405 SGTC_36 0335-0881 14.2 µM -1.17139639642698 0.0803666055881597 no 3123 0.12071974004042 936 23828853 SGTC_1911 st060208 74.3 µM -1.17147568479809 0.0803527116890548 no 3124 0.1207038129455 979 688783 SGTC_104 0074-0074 590.992 µM -1.17405880723164 0.0799010568507619 no 3125 0.120185735750518 966 3943124 SGTC_216 k038-0035 28.382 µM -1.17418082270871 0.0798797702202541 no 3126 0.120161302847825 968 4444231 YPR107C YTH1 SGTC_424 splitomicin 100 mM -1.17576836874563 0.0796032001876544 no 3127 0.119843724806862 989 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_3015 9080845 49.47 µM -1.17864705818939 0.0791035460141019 no 3128 0.119269372481654 981 5296973 SGTC_659 k018-0002 107 µM -1.1813922233757 0.0786292834098698 no 3129 0.118723472954285 985 6797879 YHR007C ERG11 SGTC_3325 9138760 55.175 µM -1.18715522115613 0.07764066655912 no 3130 0.117583199978162 947 43844959 SGTC_2365 9042475 200 µM -1.18941582375189 0.0772554574297472 no 3131 0.117138038537176 959 6464479 SGTC_2338 7999974 200 µM -1.19295108853923 0.0766559577284026 no 3132 0.116444264611547 960 315925 SGTC_3276 9139060 49.47 µM -1.19376057419036 0.076519186667563 no 3133 0.116285818989544 986 4870619 SGTC_1228 0124-0032 52.5 µM -1.19531327887177 0.0762573606180151 no 3134 0.115982326786434 960 X1228 SGTC_3007 9078383 71.4286 µM -1.19664674442227 0.0760330486157216 no 3135 0.115722136323144 976 6496995 SGTC_2623 humulene 100 µM -1.19877811010125 0.075675559627725 no 3136 0.115307118180322 986 6187145 An anti-inflammatory. SGTC_2772 vinpocetine 57.06 µM -1.20186071000484 0.0751607894631717 no 3137 0.114708749585917 976 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_757 1066-0008 322 µM -1.2070465049912 0.074300832059121 no 3138 0.113707117375593 941 6842497 SGTC_776 4476-4378 112 µM -1.21271760894212 0.0733690194968415 no 3139 0.112618902536249 1004 2892008 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -1.21291365130906 0.0733369685695017 no 3140 0.112581417891154 976 688803 SGTC_1571 st070080 73.4 µM -1.21533152210526 0.0729425514630834 no 3141 0.112119836984893 957 4315245 SGTC_2715 st079500 56.4 µM -1.21944492407703 0.0722752831277396 no 3142 0.111337683917895 972 28246688 SGTC_570 0987-0065 62.6 µM -1.21952293651685 0.072262673448193 no 3143 0.111322887882923 931 3104428 SGTC_2761 levamisole 97.89 µM -1.2236269679721 0.071601685550494 no 3144 0.110546490732045 978 26879 An alkaline phosphatase inhibitor. SGTC_2043 5101342 149 µM -1.22745777361827 0.0709888980386974 no 3145 0.109825291710988 995 678451 SGTC_1301 naphtanilide LB 4.81 µM -1.22823558986278 0.0708649695551284 no 3146 0.10967927106109 962 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_717 1532-0246 73.2 µM -1.23064001366203 0.0704829266377112 no 3147 0.109228766363213 968 9561992 SGTC_555 4296-0685 37 µM -1.23257231743345 0.0701770487857401 no 3148 0.10886768514736 995 2908540 YHR072W ERG7 SGTC_1107 amlodipine 47 µM -1.23864398867094 0.0692225641134646 no 3149 0.107738684999049 879 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_713 1488-1073 324 µM -1.24184817033652 0.0687229054938683 no 3150 0.107146293024845 994 3312542 SGTC_400 oxethazaine 37.5 µM -1.24288834487823 0.068561300521005 no 3151 0.106954490590557 984 4621 A local anesthetic. SGTC_2013 4024628 200 µM -1.24457324341417 0.0683001512551886 no 3152 0.106644330367591 1001 5230760 SGTC_1993 st073995 70.8 µM -1.25362306264611 0.0669105974276641 no 3153 0.104989522245504 975 3098394 SGTC_106 0092-0003 11.579 µM -1.25549945447526 0.0666252433858622 no 3154 0.104648753000565 973 1072148 SGTC_22 0964-0034 14.468 µM -1.25605186944949 0.0665414140780466 no 3155 0.104548582399174 998 138402 SGTC_648 0375-0473 33.3 µM -1.25732767128906 0.0663481224157505 no 3156 0.104317503993761 996 1713139 SGTC_355 1311-2252 105 µM -1.25762487190622 0.0663031572320641 no 3157 0.104263727009621 1006 5338538 SGTC_34 0469-0683 81.75 µM -1.2578501163149 0.0662690944383788 no 3158 0.104222983533184 983 3690923 SGTC_591 4299-0174 154 µM -1.25785875638702 0.0662677881054461 no 3159 0.104221420898175 1018 5509088 SGTC_466 geldanamycin 89.2 µM -1.26005472128847 0.0659364161098487 no 3160 0.10382481131911 986 5288382 HSP90 inhibitor. SGTC_3022 9087993 49.47 µM -1.26436228541882 0.0652901342940349 no 3161 0.103050011553683 996 17173644 SGTC_2062 5245942 200 µM -1.26793693310294 0.0647575553707431 no 3162 0.102410236732989 1009 1376160 SGTC_2438 5259590 200 µM -1.26799318451872 0.0647492016371816 no 3163 0.102400192235391 983 1201127 SGTC_2409 alverine citrate 63.97 µM -1.2707733036437 0.0643373760443037 no 3164 0.101904654349894 968 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1775 st081588 35.1725 µM -1.27509882296503 0.0637006775162512 no 3165 0.101137132977188 966 1426443 YGL099W LSG1 SGTC_1675 st018485 24.5 µM -1.27690100792459 0.0634368544330417 no 3166 0.100818599131944 1000 3323024 SGTC_316 k060-0003 58.6 µM -1.27748749217677 0.0633511822639189 no 3167 0.100715096740634 1001 6152314 SGTC_2943 9068529 45.32 µM -1.27824617608083 0.0632404892466951 no 3168 0.10058131965348 981 3270634 SGTC_67 0335-0847 266 µM -1.27974423437228 0.0630223628039804 no 3169 0.100317551045225 1002 4552207 YOR254C SEC63 SGTC_1122 capsaicin 818.572 nM -1.28833233088803 0.0617831740629564 no 3170 0.0988151516555138 1001 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_2165 5727197 32.143 µM -1.28921932873044 0.0616562791951233 no 3171 0.0986609235874136 989 1361712 SGTC_2940 9060638 45.86 µM -1.29100470769384 0.0614014780786706 no 3172 0.0983510225472078 971 4027022 SGTC_1146 3579-1023 7 µM -1.29268997553292 0.0611617197356979 no 3173 0.0980591531144941 1001 X1146 SGTC_473 2-arachidonoylglycerol 10 µM -1.29473454221741 0.0608718279006804 no 3174 0.0977059098212383 956 5282280 An endocannabinoid. SGTC_1818 st052136 56.3 µM -1.29637332808349 0.0606402468615052 no 3175 0.0974234482629832 947 674169 SGTC_573 3702-0553 84.7 µM -1.29675648815933 0.0605862010552192 no 3176 0.0973574931737041 982 1222756 SGTC_1682 st012968 530 nM -1.29976210311067 0.0601635567782283 no 3177 0.0968412589449384 973 24207270 SGTC_647 0140-0236 81 µM -1.30181495408328 0.0598762175942034 no 3178 0.0964898252655624 1011 990837 SGTC_719 2810-4230 27.3 µM -1.30677376238677 0.0591865635642785 no 3179 0.0956447792955957 1011 721079 SGTC_1543 azetidyl-2-carboxylic acid 198 µM -1.31062445193861 0.0586553323430132 no 3180 0.0949923369694835 995 16486 A toxic proline analog. SGTC_970 1315-0089 19.5 µM -1.31094014112561 0.0586119472154273 no 3181 0.0949389938767056 983 6811083 YLR033W RSC58 SGTC_2404 5161160 200 µM -1.31803521862076 0.0576435019900681 no 3182 0.0937459292702056 984 2831543 SGTC_1149 3909-7961 23.3 µM -1.31901095895826 0.0575113079655023 no 3183 0.0935827243759118 993 735261 SGTC_1163 k060-0048 49.9 µM -1.3199992427509 0.0573776577488665 no 3184 0.0934176354064602 1005 6809982 SGTC_3353 9151644 39.2805 µM -1.32196205109812 0.0571129427682641 no 3185 0.0930903939790743 1000 4909158 SGTC_1605 st000082 49.1 µM -1.32631372338704 0.0565294813655219 no 3186 0.0923679015266657 967 1114022 SGTC_1130 3454-2858 15.9 µM -1.32720840664147 0.056410108578677 no 3187 0.0922198761415199 992 715628 YIL048W NEO1 SGTC_1142 3253-1408 9.78 µM -1.33386114497249 0.0555286901265793 no 3188 0.0911246837568997 1007 256655 SGTC_1045 1348-1485 165 µM -1.33638990599766 0.0551965212726814 no 3189 0.090710931931178 1008 6810614 SGTC_403 arphamenine a 50 µM -1.34143912505661 0.0545379713427079 no 3190 0.0898889609124383 1005 5487158 An arginine aminopeptidase inhibitor. SGTC_2869 9037858 32.47 µM -1.34360374338007 0.0542575584281848 no 3191 0.0895382791846566 999 27187042 SGTC_1856 st057054 55.7 µM -1.34760378062718 0.0537423812764907 no 3192 0.0888929269829553 1002 1266018 SGTC_597 k018-0003 82.8 µM -1.34931085762969 0.0535237043907345 no 3193 0.0886185698048993 1015 6786234 SGTC_1249 0481-0015 10.2 µM -1.35008229767944 0.0534251143324944 no 3194 0.088494792994955 981 4227577 SGTC_194 1486-1323 56.904 µM -1.35081134676394 0.0533320741570948 no 3195 0.0883779361969793 1006 5178754 SGTC_3206 9114350 49.47 µM -1.35397837834438 0.0529293919871826 no 3196 0.0878716379587278 992 17087243 SGTC_2343 7990716 14.84 µM -1.35498228217906 0.0528022520642309 no 3197 0.0877116010396612 1006 6456862 SGTC_1549 4'-methoxyflavonol 74.6 µM -1.35680818261217 0.0525716311381197 no 3198 0.087421083435204 1002 97141 SGTC_921 1561-0023 372 µM -1.35863434332153 0.052341777669242 no 3199 0.0871312434084148 991 24050882 SGTC_3006 9075424 71.4286 µM -1.3599741454534 0.0521736487484711 no 3200 0.0869190528492224 1000 7465181 SGTC_3102 9121669 49.47 µM -1.36141915206541 0.0519927990191654 no 3201 0.0866906335361716 1031 41905072 SGTC_3301 9125354 19.7965 µM -1.36543430752739 0.0514928963455751 no 3202 0.0860582935730023 981 41905162 SGTC_2937 9044753 11.33 µM -1.38089478990204 0.0496036073525625 no 3203 0.0836556560743429 968 6465530 YGL099W LSG1 SGTC_1208 2323-2347 50.3 µM -1.38460105477124 0.0491590186456017 no 3204 0.0830872443885722 1009 5412760 SGTC_1393 3470-5649 58.2 µM -1.38621102916655 0.0489668866934899 no 3205 0.0828412373445288 994 4108395 SGTC_2591 skatole 100 µM -1.38979608170622 0.0485412071966273 no 3206 0.0822954041435397 1007 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_2354 9060492 162 µM -1.39867780829038 0.047499354540325 no 3207 0.0809548109294193 1016 6471895 SGTC_912 3474-0017 2.18 µM -1.40104950765264 0.0472241991128353 no 3208 0.0805996345289033 1018 3360550 SGTC_1960 st011366 51.8 µM -1.40247416071881 0.0470595315148768 no 3209 0.0803868506432615 997 3972846 SGTC_675 1309-0189 238 µM -1.40335346960482 0.0469581271427814 no 3210 0.0802557304833898 1006 4246530 SGTC_210 3551-0445 56.827 µM -1.40526270793628 0.0467385517038268 no 3211 0.079971586619609 1015 2865180 YOR207C RET1 SGTC_2966 9084041 48.03 µM -1.40644245112247 0.0466032854379021 no 3212 0.0797963910587373 1007 17741380 SGTC_629 3448-6466 76.7 µM -1.40679182546961 0.046563287437274 no 3213 0.079744563627994 1018 573744 SGTC_2265 7929201 200 µM -1.41255200534989 0.0459077982925639 no 3214 0.0788937446752837 1008 1265108 SGTC_1763 st044482 94.5 µM -1.41347209098101 0.0458037857226448 no 3215 0.0787584809057121 1000 88505 SGTC_1183 1254-0324 198 µM -1.41534306004607 0.0455928631514175 no 3216 0.0784839677982514 1001 5799357 SGTC_1233 0325-0408 14.2 µM -1.41536771294075 0.0455900891436012 no 3217 0.0784803555138984 1008 12874 SGTC_2806 7952793 58.44 µM -1.4165765103334 0.0454542384840362 no 3218 0.0783033901071282 995 2972490 SGTC_1797 st048695 56.8 µM -1.418854620159 0.0451990981900632 no 3219 0.0779707023687466 992 592262 YIL048W NEO1 SGTC_1588 farnesol 29.9 µM -1.42410161691125 0.0446158354827904 no 3220 0.0772085292182287 1010 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_229 benomyl 22.8748 µM -1.4265566087235 0.0443450251694914 no 3221 0.076853869464026 1001 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_972 1319-0219 195 µM -1.4286336550734 0.0441169419246059 no 3222 0.0765547778695565 1022 23903702 SGTC_560 2332-1943 155 µM -1.44118706181703 0.0427584957533339 no 3223 0.0747659212887107 1002 21177716 SGTC_1321 1326-2144 215 µM -1.44469730303448 0.0423847504585257 no 3224 0.0742714638942863 1024 3513030 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -1.44971489256169 0.0418551064355103 no 3225 0.0735690205188604 1015 16725076 SGTC_1676 st018489 23.4 µM -1.4618196759521 0.0405993976815389 no 3226 0.0718953153997285 1005 3696235 SGTC_2442 5158906 48.48 µM -1.46605879380988 0.040166942959174 no 3227 0.0713161351419483 1010 1893835 SGTC_1014 4130-3005 69.3 µM -1.46696241516294 0.0400752453581532 no 3228 0.0711931399524517 1028 743608 SGTC_32 0928-0142 34.1 µM -1.46934662085018 0.0398341173979785 no 3229 0.070869398827692 1015 2244242 SGTC_1294 1000-1494 117 µM -1.46948031809993 0.0398206308502883 no 3230 0.0708512781915146 1026 712797 YDL207W GLE1 SGTC_3156 9099931 49.47 µM -1.47128940131377 0.0396385064389804 no 3231 0.0706064341869538 1025 18111053 SGTC_430 0958-0115 16.4 µM -1.4712904668423 0.0396383993698025 no 3232 0.0706062901686128 1007 6833180 SGTC_1528 arabinosylhypoxanthine 74.6 µM -1.4714650725095 0.0396208573708361 no 3233 0.0705826932697609 1005 804 An inhibitor of viral and cellular DNA polymerases. SGTC_1821 st053465 65.6 µM -1.47206709510346 0.0395604227457296 no 3234 0.0705013800378231 1030 675086 SGTC_340 k038-0059 454 µM -1.47739710097168 0.0390286289608847 no 3235 0.0697846114090067 1020 23733424 SGTC_2234 tolnaftate 200 µM -1.48493345343758 0.0382866475359375 no 3236 0.068780726572521 1048 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_1754 st042065 16.137 µM -1.48632711176888 0.0381507050053317 no 3237 0.0685963094138841 972 1126236 YIL048W NEO1 SGTC_890 0929-0006 47.2 µM -1.48771546922916 0.0380156712216716 no 3238 0.0684129731362946 1017 1378169 SGTC_677 0929-0063 136 µM -1.48914092311673 0.0378774353149859 no 3239 0.0682251317565946 1055 1539583 SGTC_1221 2958-7315 257 µM -1.49448327305846 0.0373629965540597 no 3240 0.0675246753336756 1027 4562705 SGTC_789 1309-1135 70.6 µM -1.49907332653893 0.0369255711289503 no 3241 0.0669273052238428 1008 3092424 SGTC_502 l-744,832 89.3 µM -1.49965205391455 0.0368707176845508 no 3242 0.0668522781705829 1025 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_2364 9055074 200 µM -1.50484766061447 0.0363812413717172 no 3243 0.0661816235737713 1015 6470630 SGTC_1915 st067105 30.6 µM -1.50980800166426 0.0359189044205028 no 3244 0.065546211354156 1008 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_2180 6301957 200 µM -1.52122422544384 0.0348731067245288 no 3245 0.0641017890590173 1017 845462 SGTC_2018 5133068 143 µM -1.52595057312511 0.0344475228523947 no 3246 0.063511087190337 1018 785362 SGTC_1181 1222-0449 220 µM -1.52701503983416 0.0343522641062195 no 3247 0.0633786357804394 1027 658318 SGTC_2098 5376439 882.5 nM -1.53063194260575 0.0340302049592762 no 3248 0.0629301912873028 1022 2844116 SGTC_2040 5100729 123 µM -1.53102056434882 0.0339957491994701 no 3249 0.0628821551564532 1041 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_2300 7976697 71.57 µM -1.54288981678252 0.0329571469872724 no 3250 0.0614287559964892 1005 2236109 SGTC_1829 berberine 14.4 µM -1.54304896824034 0.0329434003582323 no 3251 0.061409447591189 972 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2455 5377712 9.75 µM -1.54967959597944 0.0323748693539438 no 3252 0.0606092189172868 1006 2243908 SGTC_532 1548-0774 215 µM -1.55109142317288 0.0322548662199873 no 3253 0.0604398881515979 1051 5932993 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -1.55114503576083 0.0322503164776329 no 3254 0.0604334653046053 1059 4620898 SGTC_896 0964-0007 44.5 µM -1.55927773234229 0.0315662580388116 no 3255 0.0594653298767367 1011 6756758 SGTC_1218 1348-1416 30.7 µM -1.5608698344011 0.0314337565495953 no 3256 0.0592772330276136 1014 6787668 SGTC_1986 st071812 45 µM -1.56372796816204 0.0311970442962184 no 3257 0.0589407333508815 1041 11838594 SGTC_2811 7967822 32.47 µM -1.5662844664405 0.0309865647526171 no 3258 0.0586410179464577 1007 2232244 SGTC_1100 amiodarone 5.07 µM -1.56683291146114 0.0309415640529307 no 3259 0.0585768761975523 1018 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_1943 st076331 65.2 µM -1.57236947030074 0.030490303300412 no 3260 0.0579324451532494 1047 24208415 SGTC_777 1315-0167 517 µM -1.58256494060814 0.0296735795549213 no 3261 0.0567603298648706 1009 4221767 SGTC_930 2810-3379 265 µM -1.59021302045794 0.0290729062405392 no 3262 0.0558933982833313 1047 1015764 SGTC_3185 9108267 49.47 µM -1.59505033802108 0.0286982293204083 no 3263 0.0553504898060747 1031 4910486 SGTC_1756 st041558 35.5 µM -1.59550057009295 0.0286635615462831 no 3264 0.055300171308337 1032 3955792 SGTC_2429 5902844 64.44 µM -1.60169857221595 0.0281898462739392 no 3265 0.0546111405286243 1023 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_496 calpeptin 138 µM -1.60258335975788 0.0281227562956366 no 3266 0.0545133349877072 1030 73364 A calpain inhibitor. SGTC_837 0091-0265 12.5 µM -1.60436609293045 0.0279879823560237 no 3267 0.0543166901924147 1051 759367 SGTC_966 1300-0360 30.2 µM -1.61211685617044 0.0274082656989703 no 3268 0.0534682566842405 986 70588 SGTC_2427 5545055 42.75 µM -1.61768780864483 0.0269978013555855 no 3269 0.0528649473281387 1031 5372858 SGTC_962 1254-0300 21.5 µM -1.62328864574159 0.0265903199116144 no 3270 0.0522638577980808 1026 7340576 SGTC_432 NS 1619 61.3 µM -1.62439524511499 0.0265104216264874 no 3271 0.0521457406180677 1016 4552 A K+/calcium channel activator. SGTC_302 1094-0063 18.9 µM -1.6348174643069 0.0257677157589396 no 3272 0.051043659285821 1035 5440289 SGTC_1428 4049-0204 61.7 µM -1.63572197955073 0.0257040878326903 no 3273 0.0509488936217655 1041 X1428 SGTC_279 1273-0055 2.93 µM -1.63795864045915 0.0255473148956943 no 3274 0.0507151609384356 1045 2847562 SGTC_533 1222-0222 6.71 µM -1.64312431590723 0.0251882982022423 no 3275 0.0501786074137105 1046 3982874 SGTC_201 4262-0159 12.803 µM -1.65614862123594 0.0243018317161586 no 3276 0.0488458625189206 1061 1341029 SGTC_2656 pseudo-anisatin 100 µM -1.66360703717294 0.0238060948797489 no 3277 0.0480954923368567 1067 6708809 A neurotoxin. SGTC_2120 5538279 151.968 µM -1.6671443366393 0.0235739705461788 no 3278 0.0477428539420703 1043 2058197 SGTC_758 0868-0029 16 µM -1.67002915265159 0.0233860755431419 no 3279 0.0474567979333675 1019 762687 SGTC_1723 st034307 2.5525 µM -1.67080599389015 0.0233356939144571 no 3280 0.0473800021234281 1025 867466 SGTC_3169 9102970 49.47 µM -1.67425859358084 0.0231128811872714 no 3281 0.0470398942022344 1068 17027839 SGTC_99 0109-0120 622.8 µM -1.68237604297738 0.0225960718274483 no 3282 0.0462479719549331 1038 759414 SGTC_2689 tacrolimus 100 µM -1.68635347005125 0.0223464205653752 no 3283 0.0458638689392497 1010 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_1152 3909-8331 15.9 µM -1.69273538591733 0.0219507099258 no 3284 0.0452529232598981 1021 16001939 SGTC_1320 1313-0481 95.3 µM -1.71562238643122 0.0205799144372848 no 3285 0.0431155892253391 1040 6813365 YLR208W SEC13 SGTC_1195 1502-0147 41.1 µM -1.72456754154317 0.0200642224211805 no 3286 0.0423027185784362 1039 817940 SGTC_2414 st077232 92.9 µM -1.73069874704778 0.0197171220062137 no 3287 0.0417527544247465 1041 729801 SGTC_381 3461-2219 42.7 µM -1.73643378933182 0.0193970765952937 no 3288 0.0412435810309692 1058 2883159 SGTC_2279 7948423 32.93 µM -1.74577661123077 0.0188851520258819 no 3289 0.0404248883209377 1039 1247112 SGTC_534 k292-0788 63.4 µM -1.75650354815811 0.0183116049515298 no 3290 0.0395012330562625 1054 4146317 SGTC_1148 3909-7663 27.7 µM -1.76143738652389 0.0180528262245508 no 3291 0.0390822009363563 1064 4084526 SGTC_2750 bromebric acid 70.15 µM -1.76170436206282 0.018038912782164 no 3292 0.0390596302378184 1048 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_948 3448-0295 75.3 µM -1.77759684682845 0.0172269844839066 no 3293 0.0377350460232551 1028 678569 SGTC_585 0kpi-0023 191 µM -1.78008457789035 0.0171027586921575 no 3294 0.0375310600487936 1040 64601 SGTC_1189 1431-2119 7.28 µM -1.78795996685456 0.0167145340121362 no 3295 0.036891233432203 1049 3107275 SGTC_1774 st048371 48.465 µM -1.79307990470491 0.0164662064421558 no 3296 0.036480074171374 1059 4242727 SGTC_2790 5423970 71.43 µM -1.80553335730129 0.0158753380774454 no 3297 0.0354956302551903 1036 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_445 e6 berbamine 66 µM -1.81056587518641 0.0156417742566666 no 3298 0.0351040392796669 1035 6610268 A calcium/calmodulin antagonist. SGTC_909 3448-9333 149 µM -1.81121209910464 0.0156119970820325 no 3299 0.0350540130174966 1053 3344074 SGTC_2580 diallyl disulphide 81.36 µM -1.81395384697786 0.01548620121197 no 3300 0.0348424157954666 1043 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_1199 1638-0010 4.46 µM -1.81681680560635 0.0153557736018445 no 3301 0.0346225843350074 1049 3111136 SGTC_158 k038-0087 26.446 µM -1.86065648088399 0.0134733500823906 no 3302 0.031396351609229 1043 X158 SGTC_391 gliotoxin 8.33 µM -1.86138343816503 0.0134438942295625 no 3303 0.0313450238566743 1056 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_1674 st016616 23.6 µM -1.8709034917749 0.0130632499145111 no 3304 0.0306792294764197 1039 625830 SGTC_2355 9061122 103.12 µM -1.87322757382211 0.0129717524222948 no 3305 0.0305184831078064 1069 5302957 SGTC_1025 k007-0731 70 µM -1.88038384867564 0.0126934863896956 no 3306 0.030027891579815 1062 6256118 SGTC_1905 st060207 84.5 µM -1.89053302763962 0.0123077084829998 no 3307 0.0293433538508158 1043 1948547 SGTC_724 3910-0327 137 µM -1.89731542647856 0.0120556032041665 no 3308 0.0288931600917986 1062 2885483 SGTC_2419 paclitaxel 166.5 µM -1.9019383003027 0.011886345480326 no 3309 0.0285896106477398 1041 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_344 k064-0035 6.43 µM -1.90326169201041 0.0118382731505061 no 3310 0.0285032034066723 1026 5088750 SGTC_307 1501-1223 22.3 µM -1.90933470836878 0.0116198272823534 no 3311 0.0281094638015968 1064 2830329 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -1.92047435814804 0.0112282215890116 no 3312 0.0273990045140662 1022 688669 SGTC_2762 leflunomide 42.06 µM -1.92230575784342 0.0111649505871452 no 3313 0.0272836479625528 1066 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_2197 6588183 93.1375 µM -1.93154470885093 0.0108504691209154 no 3314 0.0267078629670486 1061 884136 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -1.94746124104002 0.0103267524627319 no 3315 0.0257397310742202 1049 5355888 SGTC_678 1218-2179 85.9 µM -1.95077514283864 0.0102205273242534 no 3316 0.0255419000111299 1077 6820081 YOR116C RPO31 SGTC_3104 9120930 49.47 µM -1.96594211726103 0.00974643144623816 no 3317 0.024652648609754 1056 17014836 SGTC_2872 9044037 25.97 µM -1.97742506448235 0.00940038253453408 no 3318 0.0239968015617288 1075 6465195 SGTC_2706 st078239 82.5 µM -1.97957955024155 0.0093366663197462 no 3319 0.0238753963646078 1064 15434492 SGTC_999 SEC7.066 22.7 µM -1.98489410786055 0.00918110798837436 no 3320 0.0235781270397352 1073 740511 YDR170C SEC7 SGTC_2486 5283202 22.39 µM -1.98847116974719 0.00907768828674157 no 3321 0.0233798022330152 1053 1377751 SGTC_2875 9039966 71.43 µM -1.99655389292459 0.00884775056653557 no 3322 0.0229368328833421 1071 6463691 SGTC_1289 0976-0073 69.1 µM -1.99934067907335 0.00876966381677715 no 3323 0.0227857528000833 1070 3391136 SGTC_2498 4'-Methoxychalcone 54.63 µM -2.00723541922046 0.00855172122091545 no 3324 0.0223623009550843 1059 641818 YHR062C RPP1 SGTC_1857 st056007 79.3 µM -2.01985190580865 0.00821328943246694 no 3325 0.0216993756110234 1072 619834 SGTC_92 0063-0024 660.874 µM -2.02172422996349 0.00816408099468294 no 3326 0.0216024246289595 1078 3594437 SGTC_1852 st056254 31.4 µM -2.02208573043908 0.0081546099288503 no 3327 0.0215837479624154 1069 442583 SGTC_566 0958-0068 16.5 µM -2.02597227354836 0.00805339341134416 no 3328 0.0213838130059435 1047 6815365 SGTC_2228 7354201 200 µM -2.02985846134074 0.00795329196722713 no 3329 0.0211854642230606 1084 753451 SGTC_2356 9061756 188.97 µM -2.05755260548692 0.00727108295928797 no 3330 0.0198165501018871 1069 20104043 SGTC_549 1661-1316 519 µM -2.0835884782973 0.00667732558505262 no 3331 0.0185988079676502 1070 2857282 SGTC_927 2425-1185 123 µM -2.11013133532704 0.00611652948570469 no 3332 0.0174235224479141 1070 730375 SGTC_2314 7727897 200 µM -2.15462675154476 0.00526958671672885 no 3333 0.015595526951787 1049 900724 SGTC_755 1995-0008 37.3 µM -2.19733781666973 0.00455642587306346 no 3334 0.0139981643697562 1077 689533 SGTC_3326 9140064 16.379 µM -2.22588509107475 0.0041291116385986 no 3335 0.0130109396236591 1078 1868434 SGTC_2274 7947094 46.08 µM -2.25263008132639 0.0037616878782163 no 3336 0.0121412413965341 1077 2971028 SGTC_1017 4239-0030 168 µM -2.30983920595707 0.00307245017756548 no 3337 0.0104485289197633 1074 1149593 SGTC_2100 5377183 190 µM -2.32370237530393 0.00292356956887732 no 3338 0.0100707255378011 1060 2844202 SGTC_1914 st062367 72.6 µM -2.34064230067175 0.00275049254654565 no 3339 0.00962530039772856 1071 978205 SGTC_924 2046-0044 21.3 µM -2.37155773469159 0.00245829318126236 no 3340 0.00885663952844905 1076 3623589 SGTC_1292 0kpi-0043 232 µM -2.38946859213122 0.00230214653832419 no 3341 0.00843638323273978 1086 3333905 SGTC_1853 st056710 91.2 µM -2.40604413460801 0.00216570261573386 no 3342 0.00806315818305972 1080 269167 SGTC_2503 beta-caryophyllene alcohol 24.72 µM -2.40946890707595 0.00213844196504385 no 3343 0.00798787864227027 1087 61125 An anti-inflammatory. SGTC_2267 7931562 200 µM -2.48879547767604 0.00158800178704995 no 3344 0.00640883388494868 1079 934880 SGTC_544 k015-0020 52.4 µM -2.49670227108842 0.00154090867869603 no 3345 0.00626770773550954 1086 3008304 SGTC_1165 k072-0275 30.3 µM -2.75573560992225 0.000549749506938014 yes 3346 0.00292801557148493 1090 6153523 YGL055W OLE1 SGTC_2017 5132927 60.65 µM -2.83591784099857 0.000392633765293902 yes 3347 0.0022847099565508 1087 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_1131 3454-3128 32.3 µM -2.92951570016045 0.000262284620243066 yes 3348 0.00169745331159163 1079 710982 SGTC_1348 1493-0373 93.8 µM -2.93534997381126 0.000255674509549476 yes 3349 0.00166585839853796 1091 3010129 SGTC_1180 1193-0155 285 µM -3.02353926890984 0.000172894045237536 yes 3350 0.00124918301163388 1091 2921347 SGTC_359 0081-0058 15.9 µM -3.3569792938235 3.59316287102112e-05 yes 3351 0.000393995068086453 1087 3494159 SGTC_1376 2910-0861 41.3 µM -3.48524196990871 1.88859666138958e-05 yes 3352 0.000245846094411677 1094 1112859 SGTC_1469 k284-2957 126 µM -3.49652431035983 1.78286121290056e-05 yes 3353 0.000235680771264983 1067 23884841 SGTC_1184 1269-1718 139 µM -3.71609448907247 5.6185682303933e-06 yes 3354 0.000101162972214129 1095 5403821 SGTC_760 0568-0725 82.9 µM -3.92816902593003 1.73353411593525e-06 yes 3355 4.27975229774628e-05 1094 3916171 SGTC_1373 2887-0003 58.5 µM -3.9680661620517 1.38025186159737e-06 yes 3356 3.62291098551261e-05 1094 776948