SGTCid condition conc unit YAL065C|YAL065C.score YAL065C|YAL065C.strain.pval YAL065C|YAL065C.strain.significant YAL065C|YAL065C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_2038 4100038 30.985 µM 6.14679034600498 3.3816343789897e-10 yes 1 3.9533262375551e-10 21 3596803 SGTC_3280 9140961 49.47 µM 6.09634278918496 4.6431463351102e-10 yes 2 5.42612863952226e-10 3 4901226 SGTC_2336 9001819 198.65 µM 5.90669753528284 1.495564377774e-09 yes 3 1.74516861567047e-09 9 2989602 SGTC_2830 7992007 71.43 µM 5.61644208522015 8.37445678434384e-09 yes 4 9.74647721142481e-09 3 1952075 SGTC_173 1273-0061 2.693 µM 5.28080828801708 5.54524206787007e-08 yes 5 6.43076070866986e-08 136 2847414 YPL266W DIM1 SGTC_1738 st035555 74 µM 5.00840282017753 2.37414356779419e-07 yes 6 2.74417874027341e-07 14 5331140 SGTC_309 k408-0051 1.48 µM 4.99838760219235 2.5011289664936e-07 yes 7 2.89058443173198e-07 27 3640463 SGTC_2887 9044784 58.44 µM 4.8889703982724 4.39168675474928e-07 yes 8 5.06823675295467e-07 12 6465546 SGTC_512 prima-1 270 µM 4.63338448479904 1.56417125725265e-06 yes 9 1.79867763048922e-06 13 322968 A re-activator of the apoptotic function of mutant p53. SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 4.40350269371215 4.64768461256472e-06 yes 10 5.32584803632372e-06 61 6708739 YPR165W RHO1 SGTC_2869 9037858 32.47 µM 4.0062278003908 2.70990149371892e-05 yes 11 3.08480748629597e-05 11 27187042 SGTC_2832 7992762 51.95 µM 3.95443955800469 3.37264127255714e-05 yes 12 3.83571306841016e-05 31 2985177 SGTC_341 1486-1430 230 µM 3.78858865756233 6.68089742748178e-05 yes 13 7.5752763285507e-05 28 2054753 YPL210C SRP72 SGTC_1980 st071811 45.7 µM 3.73511041254837 8.28227901458113e-05 yes 14 9.38164231126998e-05 23 4974850 SGTC_829 1635-0120 117 µM 3.67331151832425 0.000105809307145583 yes 15 0.000119713649436669 51 285054 SGTC_2028 5153890 36.43 µM 3.60019444144262 0.000140721693011109 yes 16 0.000158989652696575 41 2830968 YPR165W RHO1 SGTC_2047 4141938 200 µM 3.55373713011129 0.000168232444298906 yes 17 0.000189899314586234 11 3807862 SGTC_3263 9137018 49.47 µM 3.54444755377331 0.000174305310414762 yes 18 0.000196718385021713 28 43844957 SGTC_409 arachidonic acid 100 µM 3.4711003786678 0.000229971560418882 yes 19 0.000259165100530618 27 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_2136 5328288 199.296 µM 3.43766254172543 0.000260506414487925 yes 20 0.000293379221536599 32 262395 SGTC_988 1497-1057 103 µM 3.31636420196171 0.000405895175448268 yes 21 0.000455984481869755 24 3533044 SGTC_1030 k029-0042 36.7 µM 3.30608306499774 0.000421175774371364 yes 22 0.000473050180279344 56 6080581 SGTC_2037 5169046 200 µM 3.28751888656322 0.000450126538463476 yes 23 0.000505372045665726 26 5718022 SGTC_1327 1436-0082 2.18 µM 3.28140207273124 0.00046006262622242 yes 24 0.000516461926195779 42 15992205 SGTC_3038 9091290 49.47 µM 3.25988778286167 0.000496647340138502 yes 25 0.000557281511194558 40 25236843 SGTC_3259 9138485 49.47 µM 3.25329201672028 0.000508391674768854 yes 26 0.000570381000155427 31 17646153 SGTC_866 0495-0101 262 µM 3.2070509151825 0.000598225438059558 yes 27 0.000670516294345545 42 635694 SGTC_507 nimesulide 162 µM 3.20578904209762 0.000600870888586033 yes 28 0.000673463477980295 42 4495 A COX2 inhibitor. SGTC_2556 citropten 84.59 µM 3.20563411619916 0.000601196426401476 yes 29 0.000673826139634971 64 2775 A potential DNA crosslinker. SGTC_3221 9128209 49.47 µM 3.19627436133342 0.000621168568443675 yes 30 0.000696073326706528 38 16460723 SGTC_1741 st038134 10.228 µM 3.1895211400347 0.000635957389881754 yes 31 0.000712543578219178 66 1272587 SGTC_1221 2958-7315 257 µM 3.05951622870123 0.000992095592090689 yes 32 0.00110847388076382 51 4562705 SGTC_1222 0366-0074 1.18 µM 3.04930004793123 0.00102669420462868 no 33 0.00114687633014833 50 286520 SGTC_1855 st056195 39.6 µM 3.02055301898461 0.00113007555830899 no 34 0.00126156764815524 62 4028379 SGTC_1967 st070177 51.4 µM 3.0154430883539 0.00114942090458728 no 35 0.0012830204502436 57 5729214 SGTC_938 3126-1755 342 µM 2.8977473037523 0.00168797145244667 no 36 0.00187926643206285 48 1777771 SGTC_985 1493-0307 8.71 µM 2.83249254740038 0.00207730590687609 no 37 0.00230933214073112 58 3278274 SGTC_1748 st037455 53.6035 µM 2.82763238951255 0.0021093351152705 no 38 0.0023446810586464 98 580690 SGTC_2294 7971431 200 µM 2.80925909791927 0.00223450585046904 no 39 0.00248278329729617 69 5741572 SGTC_3147 9097027 49.47 µM 2.80722333597656 0.00224878109484442 no 40 0.0024985291771812 76 25236841 SGTC_2206 7254556 146.969 µM 2.80436290491493 0.00226897873815248 no 41 0.00252080615823706 29 4398905 SGTC_634 1611-4317 11.2 µM 2.78694277316251 0.00239557092793664 no 42 0.00266039371594169 75 2843522 SGTC_155 k072-0202 43.6 µM 2.77901200631482 0.00245529359717733 no 43 0.00272622548797433 62 5857737 SGTC_3097 9117246 49.47 µM 2.77592806017422 0.00247887863956378 no 44 0.00275221932585021 75 16423892 SGTC_495 decylubiquinone 155 µM 2.76134220655998 0.00259322639391884 no 45 0.002878216276653 103 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_2019 4016004 108 µM 2.74695218256492 0.0027106882198194 no 46 0.00300759518417559 91 45595336 SGTC_636 0kpi-0074 126 µM 2.74035680068083 0.00276611274978864 no 47 0.00306862596140627 68 616434 SGTC_1010 4112-3296 15.2 µM 2.70663027892359 0.00306584261129237 no 48 0.00339849537329271 92 704384 SGTC_314 1671-0008 2.74 µM 2.69767714687536 0.00315017529408594 no 49 0.00349125614847449 140 3913060 SGTC_1818 st052136 56.3 µM 2.64080660034466 0.0037363621597443 no 50 0.00413544590568476 145 674169 SGTC_2347 9049783 174.81 µM 2.57030183183949 0.0045978099297758 no 51 0.00508049710401765 134 6467988 YPL169C MEX67 SGTC_3085 9117376 49.47 µM 2.56995072812675 0.00460251047909635 no 52 0.00508564901961296 88 16480349 SGTC_310 1273-0058 1.06 µM 2.5628703386142 0.00469822199390533 no 53 0.00519054045054331 430 2734232 SGTC_3254 9136651 49.47 µM 2.55185180983085 0.00485070245653355 no 54 0.00535760415935054 94 16454030 SGTC_2529 gangaleoidin 93.61 µM 2.53927826367706 0.00503007819186375 no 55 0.00555407170583262 84 4565183 SGTC_3000 9075062 71.4286 µM 2.52876565689944 0.00518456151012122 no 56 0.00572322125739979 101 17057871 SGTC_73 0327-0325 16.231 µM 2.50182605324828 0.00559987857269616 no 57 0.00617773068190203 191 53298 SGTC_4 0960-0234 25.671 µM 2.49482660680125 0.00571251113974424 no 58 0.00630093465342757 92 6821112 SGTC_2791 5663188 71.43 µM 2.48105700579924 0.00593997077318725 no 59 0.00654967109441056 113 54690634 SGTC_3102 9121669 49.47 µM 2.47932046569334 0.00596921954373715 no 60 0.00658164896115767 72 41905072 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 2.47606684154598 0.00602436468684152 no 61 0.00664193530387984 130 115019 SGTC_2945 9067681 61.76 µM 2.42400065561041 0.00697034013471976 no 62 0.00767528888699285 88 16456930 SGTC_622 1348-1566 26.3 µM 2.40047793912101 0.00743912629912073 no 63 0.00818683883911857 135 7340407 SGTC_1655 st012546 55.1 µM 2.38742663712108 0.00771103069170839 no 64 0.00848339435635982 117 720985 YLR208W SEC13 SGTC_1375 2910-0797 186 µM 2.38464906082951 0.00777001361738437 no 65 0.00854771037064021 129 742508 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 2.37807331121789 0.00791123735440982 no 66 0.00870168274406806 103 17037758 SGTC_2817 7995342 71.43 µM 2.36884659706963 0.00811319883206065 no 67 0.0089218263509732 125 18879975 SGTC_2040 5100729 123 µM 2.36725452938932 0.0081485018807059 no 68 0.00896030175176732 140 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_831 k061-1017 217 µM 2.36633857446152 0.00816887368348018 no 69 0.00898250338436403 253 1240153 SGTC_934 2950-0684 338 µM 2.31767083820663 0.00931769239909625 no 70 0.0102336085321036 151 1121253 SGTC_1239 0337-0584 35.4 µM 2.31050764457304 0.00949819968647881 no 71 0.0104300329013332 215 914301 YML130C ERO1 SGTC_1883 5-benzylidenerhodanine 20 µM 2.29536453670462 0.00988988614606269 no 72 0.0108561209650962 227 1273210 SGTC_1650 st011916 45.8 µM 2.29235699694187 0.00996933536836812 no 73 0.0109425256703414 101 242528 SGTC_2371 9071574 200 µM 2.28837870625286 0.0100752841909322 no 74 0.0110577382971262 110 45596039 SGTC_3275 9138069 49.47 µM 2.27861227286679 0.010339557764689 no 75 0.0113450618696253 105 17617007 SGTC_1267 0828-0272 9.49 µM 2.26781712473878 0.0106386807040613 no 76 0.011670177606956 154 745334 SGTC_2911 7942208 15.64 µM 2.25602110313066 0.010974128032605 no 77 0.012034654769187 133 1243384 SGTC_2255 7941087 197.44 µM 2.22875632986683 0.0117848748572876 no 78 0.0129150610144199 187 935561 SGTC_2485 5633444 17.78 µM 2.22038809682072 0.0120439190428182 no 79 0.0131962171781364 209 5724239 SGTC_1491 4138-0063 26.5 µM 2.21867591897894 0.012097524860002 no 80 0.013254390229365 107 23883227 SGTC_2225 6654152 15.4 µM 2.21024075907949 0.012364647634251 no 81 0.0135442288026252 104 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_404 fumagillin 50 µM 2.20178544869025 0.0126375209871008 no 82 0.0138402337145546 180 12015870 A methionine aminopeptidase binder. SGTC_1959 st077091 55.8 µM 2.19764195750818 0.0127731338570986 no 83 0.013987315385506 202 821356 YKL052C ASK1 SGTC_3207 9114163 49.47 µM 2.19350203959892 0.0129098853206574 no 84 0.0141356139000667 218 849233 SGTC_2884 9058502 51.95 µM 2.19160984401174 0.0129728095222923 no 85 0.0142038452663954 180 6471554 SGTC_3197 9113331 49.47 µM 2.18724273378658 0.013119049087654 no 86 0.014362404389113 215 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_1508 1080-0625 72.9 µM 2.18362380412817 0.0132413120177618 no 87 0.0144949514590952 136 767111 SGTC_2229 7354935 190 µM 2.18255001595537 0.013277778025178 no 88 0.0145344820744081 102 318112 SGTC_130 0136-0219 337.655 µM 2.16042855022196 0.0140485617363094 no 89 0.0153697546276877 178 234244 SGTC_3006 9075424 71.4286 µM 2.15023295329571 0.014416600510775 no 90 0.0157683963854968 172 7465181 SGTC_2363 9053361 176 µM 2.14500565334903 0.0146084928581192 no 91 0.0159761974922326 203 6469797 YMR079W SEC14 SGTC_1764 st044502 93.5 µM 2.12456759533096 0.0153800081876613 no 92 0.0168113550875239 205 8407 SGTC_3055 9094636 49.47 µM 2.12247921173961 0.0154607777912829 no 93 0.0168987582902369 164 25236176 SGTC_1320 1313-0481 95.3 µM 2.1107032209706 0.0159230696703102 no 94 0.0173989144866931 166 6813365 YLR208W SEC13 SGTC_2097 5376186 200 µM 2.10831962339966 0.0160180714600113 no 95 0.0175016758329522 207 742755 SGTC_1097 itavastatin 7.23 µM 2.0819089950774 0.0171036304079578 no 96 0.0186753915042594 213 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_1270 0831-1170 17.3 µM 2.07965992317692 0.0171989131948951 no 97 0.018778368241153 192 6764716 SGTC_1638 st008370 60.6 µM 2.07837554082306 0.0172535297265315 no 98 0.0188373918523406 227 24207134 SGTC_3112 9123419 49.47 µM 2.07517572661341 0.0173902420376533 no 99 0.0189851257093342 202 17015854 SGTC_1565 sinapyl alcohol 95.1 µM 2.05582186730042 0.018237007897265 no 100 0.0198998447225858 216 5280507 A phenol propionate derived from cinnamic acid. SGTC_1831 st055328 12 µM 2.049785664532 0.0185081879238217 no 101 0.0201926755636251 211 1103068 SGTC_2263 7948595 193.29 µM 2.0472799141555 0.0186217646930698 no 102 0.0203153044399627 139 2971371 SGTC_565 1418-0001 44.5 µM 2.04082898336854 0.018916895664674 no 103 0.0206339143143934 239 2862145 SGTC_1784 st039334 36.3 µM 2.01983761827736 0.0199049398696327 no 104 0.0217001168458898 215 3496984 SGTC_3349 9149703 23.001 µM 2.01170535028185 0.0202993163326582 no 105 0.022125503146821 184 4910494 SGTC_1152 3909-8331 15.9 µM 2.0066921115862 0.0205457197107296 no 106 0.022391228244827 194 16001939 SGTC_53 0973-0023 39.979 µM 1.9936719304349 0.02119753227691 no 107 0.0230939594274589 197 674768 SGTC_1968 st069590 43.6 µM 1.98737162881209 0.0215191638997204 no 108 0.0234406146448759 199 6384066 SGTC_2560 caryophyllene 100 µM 1.98716228218732 0.021529921506388 no 109 0.0234522080668481 242 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_5 0352-0601 109.883 µM 1.9837215969193 0.0217073788009897 no 110 0.0236434422958638 164 762456 SGTC_2942 9052777 62.25 µM 1.97994774110202 0.0219034391472172 no 111 0.0238547005624949 272 6469503 SGTC_670 4204-0025 119 µM 1.97980810539695 0.0219107221327924 no 112 0.0238625476315887 248 719039 SGTC_1644 st010134 20.9 µM 1.9760891677879 0.0221054447086804 no 113 0.0240723395255157 183 3818134 SGTC_1718 roemerine 11.9335 µM 1.96209081584667 0.0228515403501182 no 114 0.0248759560085374 295 235224 An aporphine alkaloid with mutagenic activity. SGTC_3041 9091929 49.47 µM 1.95723666720795 0.023115166428142 no 115 0.0251598248407653 244 25236887 SGTC_323 4013-0906 34.3 µM 1.94596071699973 0.0237374540847793 no 116 0.0258297292676269 193 2910086 SGTC_2357 9067248 200 µM 1.93354186557841 0.0244390545895799 no 117 0.0265847404473628 202 9150235 SGTC_12 0849-0099 9.267 µM 1.92803920935306 0.0247554465668368 no 118 0.0269251246758672 216 6071388 SGTC_2017 5132927 60.65 µM 1.92708453431316 0.0248106867895374 no 119 0.0269845479039601 273 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_1464 k208-0027 110 µM 1.92461524507026 0.0249540466339073 no 120 0.0271387553716412 235 X1464 SGTC_2290 7904846 200 µM 1.92291687406398 0.0250530517901678 no 121 0.0272452451182434 261 2962154 SGTC_1198 1612-1005 86.7 µM 1.9199701560924 0.0252256095543375 no 122 0.027430834596422 219 6998509 SGTC_47 0149-0135 24.25 µM 1.90717865795013 0.0259862576742587 no 123 0.0282487280938679 238 5239155 SGTC_2966 9084041 48.03 µM 1.90582249460544 0.0260680154556693 no 124 0.0283366197052914 256 17741380 SGTC_3328 9140624 29.0385 µM 1.90506093675947 0.0261140210488111 no 125 0.0283860752212029 241 4904392 SGTC_1107 amlodipine 47 µM 1.89932866299346 0.0264624903471456 no 126 0.0287606382432935 272 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_1058 3448-5425 97.3 µM 1.89929536306065 0.0264645259722678 no 127 0.0287628261030477 243 7279705 SGTC_974 1326-0144 138 µM 1.89903079092783 0.0264807039188464 no 128 0.0287802138403648 286 5411856 SGTC_2528 xanthyletin 44.79 µM 1.88952679887571 0.0270673536722269 no 129 0.0294106376688928 233 65188 An natural product with antifungal activity of unknown mechanism. SGTC_25 0118-0223 35.662 µM 1.88607961033261 0.0272828001801601 no 130 0.0296421137459429 251 5333628 SGTC_814 3342-0569 96 µM 1.88539410420867 0.0273258138265576 no 131 0.0296883247153014 279 4346283 SGTC_1652 st011932 78 µM 1.8825664413674 0.0275038402695349 no 132 0.0298795739135043 226 1551076 SGTC_2692 st077426 47.7 µM 1.87395761266027 0.0280518053504998 no 133 0.0304681338108714 272 25238571 SGTC_2006 4011487 200 µM 1.86814952614382 0.0284266110029765 no 134 0.0308706159433855 353 45595294 SGTC_1217 1183-1422 255 µM 1.86814324569442 0.0284270185352417 no 135 0.0308710535291961 260 2849664 SGTC_2679 rapamycin 1 nM 1.86749686492618 0.0284689875597632 no 136 0.0309161171093673 419 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_2117 5521686 200 µM 1.8648758645622 0.0286396958378282 no 137 0.0310994031040937 256 803312 SGTC_2696 st077691 74.316 µM 1.86208709301851 0.0288222651345447 no 138 0.0312954075080346 246 757133 SGTC_933 2914-0560 114 µM 1.86106104233317 0.0288896794311311 no 139 0.0313677784594733 289 463887 SGTC_185 k048-0037 25.491 µM 1.85664092511782 0.0291815932485218 no 140 0.0316811286766518 226 6827589 SGTC_2851 9015922 71.43 µM 1.855392160706 0.0292645067814926 no 141 0.031770123018481 273 2996893 SGTC_1041 0206-0046 107 µM 1.85355804417608 0.0293866402772728 no 142 0.03190120737323 253 50494 SGTC_3348 9149464 3.537 µM 1.8526868651862 0.0294448000214432 no 143 0.0319636268642557 263 1951442 SGTC_3295 9122362 53.5725 µM 1.85080221462641 0.0295709459638998 no 144 0.0320990061832865 238 4730473 SGTC_1160 4092-0570 10.5 µM 1.83942014738108 0.0303423544258653 no 145 0.0329267065043597 304 4994975 SGTC_3005 9076496 71.4286 µM 1.82851988460617 0.0310966677799708 no 146 0.033735782081569 222 21368410 SGTC_253 dyclonine 31.25 µM 1.82094864763791 0.0316296862221951 no 147 0.0343073316407568 319 3180 An oral anasthetic. SGTC_2546 rhodinyl acetate 100 µM 1.82034249124712 0.0316726843801036 no 148 0.0343534321677223 263 6708682 SGTC_1930 st074634 34.3 µM 1.82018464408003 0.0316838893105373 no 149 0.0343654454033301 298 684253 YOR116C RPO31 SGTC_1104 tacrolimus 29.8 µM 1.81900353651801 0.0317678353400355 no 150 0.0344554452677167 293 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_396 dithiazanine 1.25 µM 1.81670396111209 0.0319318025126116 no 151 0.0346312274498908 217 10578 An antihelmenthic. SGTC_1081 sertraline 6 µM 1.81584192708129 0.0319934481736637 no 152 0.0346973118413041 322 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_2806 7952793 58.44 µM 1.81199063223306 0.0322700629543714 no 153 0.0349938219888795 283 2972490 SGTC_1634 st006576 41 µM 1.81167661061362 0.0322927039584966 no 154 0.0350180898472874 273 3915356 SGTC_1619 st003326 88.7 µM 1.8099852078794 0.032414879919988 no 155 0.0351490405492426 221 2849032 SGTC_2658 polymyxin b sulfate 77.05 µM 1.80593863112014 0.0327087266018546 no 156 0.0354639630003569 288 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_1269 0831-0796 3.05 µM 1.79727936099647 0.0333449112013535 no 157 0.0361456405279637 275 927758 SGTC_551 k048-0028 34.9 µM 1.79065219567246 0.0338386537513526 no 158 0.0366745627316811 311 6836383 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 1.78746271243946 0.034078414347651 no 159 0.0369313667705523 377 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_2836 9010338 19.48 µM 1.78525166045181 0.0342454425158201 no 160 0.0371102529273732 297 2994051 SGTC_1297 1068-0111 14.1 µM 1.78112368582267 0.0345590804063581 no 161 0.0374461235508794 264 767057 SGTC_1342 1486-1464 234 µM 1.77739955234428 0.0348440559667538 no 162 0.0377512621950236 282 3253938 SGTC_397 arbidol 50 µM 1.76687510842842 0.035659844296136 no 163 0.0386245732594495 308 131410 A RNA synthesis inhibitor. SGTC_2091 4-phenylthiadiazole 200 µM 1.76586588584862 0.0357388887219787 no 164 0.038709175840977 312 270010 SGTC_1821 st053465 65.6 µM 1.76402920958554 0.0358831094651605 no 165 0.0388635307692058 255 675086 SGTC_11 0438-0307 1.3 µM 1.76156154105254 0.0360776277070072 no 166 0.0390717033193854 260 4011476 SGTC_2118 5526350 200 µM 1.76073042411195 0.0361433360158553 no 167 0.0391420203797624 304 743594 SGTC_2792 7535235 81.82 µM 1.75812312008742 0.0363501062747655 no 168 0.0393632813361049 292 1281891 SGTC_3268 9137683 49.47 µM 1.75762574995792 0.0363896595874116 no 169 0.0394056045065172 215 1953228 SGTC_1656 st012921 11 µM 1.75699167114619 0.0364401357154851 no 170 0.0394596144303914 256 6732821 SGTC_2656 pseudo-anisatin 100 µM 1.74987652547587 0.0370104783267409 no 171 0.0400698110657163 210 6708809 A neurotoxin. SGTC_1674 st016616 23.6 µM 1.74543141770068 0.0373704822370649 no 172 0.0404549004020942 323 625830 SGTC_535 2293-4129 48.2 µM 1.74172865623009 0.0376725436107175 no 173 0.0407779678515379 388 396118 YIL048W NEO1 SGTC_3334 9142812 21.919 µM 1.7388856988873 0.0379058146319846 no 174 0.0410274351207589 301 45283678 SGTC_1815 st051655 58.2 µM 1.73732110224037 0.0380346952685253 no 175 0.0411652544051495 258 5984156 SGTC_3314 9135860 59.4275 µM 1.73694142224862 0.0380660245156917 no 176 0.0411987554872139 293 25252478 SGTC_1612 st002233 45.4 µM 1.72858025392702 0.0387612975536826 no 177 0.0419421230968847 303 1035021 SGTC_2536 dehydroabietamide 32.04 µM 1.724997367266 0.0390623820505166 no 178 0.0422639734877707 339 3983547 SGTC_3329 9141233 27.5565 µM 1.72262532838913 0.0392627596188358 no 179 0.0424781508136364 283 4909101 YNL103W MET4 SGTC_2067 5224629 34.075 µM 1.71592239623217 0.0398335136824577 no 180 0.0430881234919642 337 2835000 SGTC_1274 0865-0114 173 µM 1.71068894032768 0.0402838152804492 no 181 0.043569275210087 330 870624 SGTC_3123 9126162 49.47 µM 1.71039258558116 0.0403094376832314 no 182 0.0435966505834725 298 25239884 SGTC_884 0851-0618 334 µM 1.7097815265922 0.0403623107405418 no 183 0.0436531401595249 345 9642473 SGTC_1012 4112-3522 18 µM 1.70782413948648 0.0405320566808524 no 184 0.0438344892709105 324 3112398 SGTC_2230 bromochlorosalicylanilide 954.5 nM 1.70658533833938 0.0406397854835492 no 185 0.0439495761085144 202 77254 SGTC_3007 9078383 71.4286 µM 1.70612636871476 0.0406797574179285 no 186 0.0439922770242034 319 6496995 SGTC_3018 9082602 49.47 µM 1.69895555518659 0.0413084212722342 no 187 0.0446637790689855 336 17332089 SGTC_1733 st037357 54.9 µM 1.69255810540759 0.0418759099780975 no 188 0.0452698056022639 367 1272339 YGL099W LSG1 SGTC_1186 1319-0216 26 µM 1.6859631836812 0.0424675064933584 no 189 0.0459014453800192 345 4565136 SGTC_1451 4152-0210 104 µM 1.68487561736611 0.0425657126381333 no 190 0.0460062858666576 347 659563 SGTC_1802 st050112 57.9 µM 1.68404735882305 0.0426406266666936 no 191 0.0460862582704525 318 4662563 SGTC_2765 myclobutanil 7.74 µM 1.67943204456153 0.0430600250465988 no 192 0.0465339362228303 342 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_1516 st013856 110 µM 1.67757779818117 0.0432294579599348 no 193 0.046714775012604 302 5281404 A mutagen and neurotoxin. SGTC_537 1334-0398 209 µM 1.67720119731767 0.0432639357924053 no 194 0.0467515725021142 343 5846986 SGTC_2973 9094665 17.96 µM 1.67499308160476 0.0434665359568182 no 195 0.0469677945407068 386 25237061 YIL048W NEO1 SGTC_2813 7971799 71.43 µM 1.67365313940988 0.0435898519449873 no 196 0.0470993941982175 315 2234054 SGTC_760 0568-0725 82.9 µM 1.66706440225286 0.0442003322226866 no 197 0.0477507997867211 312 3916171 SGTC_1692 fluoroquinolonic acid 71 µM 1.65758516774117 0.0450907028234726 no 198 0.048700612733893 291 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_859 0439-0102 54.6 µM 1.65644659134649 0.0451986118314321 no 199 0.048815706221403 361 610143 SGTC_1716 st033144 30.6155 µM 1.64109612715156 0.0466738384864157 no 200 0.0503887312813905 349 674617 SGTC_1096 rimcazole 32.2 µM 1.64065848069623 0.0467164574404112 no 201 0.0504341640546172 303 18528119 A dopamine reuptake inhibitor. SGTC_2998 9066762 71.4286 µM 1.63322841067651 0.0474447894349746 no 202 0.0512104834050862 406 4945196 SGTC_1190 1486-1332 13 µM 1.62513131646786 0.0482488364326454 no 203 0.0520672906787735 337 4150046 SGTC_952 1185-0122 232 µM 1.62253242556927 0.0485092067701509 no 204 0.0523446980306439 371 678600 SGTC_2062 5245942 200 µM 1.62078625003043 0.0486847778452208 no 205 0.0525317441920761 386 1376160 SGTC_2923 7992654 58.14 µM 1.62056121914727 0.0487074407162983 no 206 0.0525558875050079 365 2985126 SGTC_2424 5537928 59.2 µM 1.61645743033933 0.049122214474806 no 207 0.0529977250687122 405 5382802 SGTC_989 1501-0895 10.3 µM 1.61375046115805 0.0493973511633751 no 208 0.0532907818798409 328 2830112 SGTC_889 0919-1524 82.7 µM 1.61207374302721 0.0495683891009759 no 209 0.0534729468303599 346 3905452 SGTC_1956 st077085 54 µM 1.611932149828 0.0495828542930894 no 210 0.0534883526120037 400 24208685 SGTC_2822 7994718 71.43 µM 1.6053240500672 0.0502616946235285 no 211 0.0542112545534222 294 1018011 SGTC_1724 st037281 8.293 µM 1.5966924921511 0.051159536102765 no 212 0.0551671350183433 398 574124 YDL195W SEC31 SGTC_2461 5755302 26.15 µM 1.59402945521857 0.0514391026964177 no 213 0.0554647188759829 405 2788904 SGTC_1363 1636-0063 10.4 µM 1.59352279254389 0.0514924296499153 no 214 0.0555214796655583 397 6072185 SGTC_94 0334-0113 514.748 µM 1.59060350214723 0.0518005459776611 no 215 0.0558494179160821 377 6795178 SGTC_2302 7771753 200 µM 1.5880439827384 0.0520718942615557 no 216 0.0561381969170669 435 2203047 SGTC_2598 perillyl alcohol 100 µM 1.58355379934527 0.0525506493505253 no 217 0.056647647319616 390 10819 An apoptosis inducer. SGTC_2277 7947813 106.88 µM 1.58079301370489 0.0528467416591704 no 218 0.0569626862345166 385 1246798 SGTC_403 arphamenine a 50 µM 1.5689967110708 0.0541268222574805 no 219 0.0583243526864987 399 5487158 An arginine aminopeptidase inhibitor. SGTC_776 4476-4378 112 µM 1.56608577103787 0.0544464492080964 no 220 0.0586642693748916 343 2892008 SGTC_23 0213-0011 39.996 µM 1.56541343001884 0.0545204853910611 no 221 0.0587430007126645 369 627608 SGTC_1693 xanthone 101.9 µM 1.56353715825417 0.0547275159976035 no 222 0.0589631513856457 400 7020 An insecticide. SGTC_2655 perillic acid 100 µM 1.55911504488559 0.0552179171989797 no 223 0.0594845766937249 308 5702197 An apoptosis inducer. SGTC_1844 rapamycin 4 nM 1.55171896382232 0.0560458741006816 no 224 0.0603647415494009 556 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_735 3076-0345 636 µM 1.5514694456811 0.0560739763041632 no 225 0.0603946120324913 455 2888990 SGTC_2309 7664088 163.95 µM 1.55137403629386 0.0560847248081431 no 226 0.0604060368016365 442 704922 SGTC_2683 piperine 63.03 µM 1.55037279389347 0.0561976194633617 no 227 0.0605260323036554 341 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_848 0368-0089 85.6 µM 1.55015187047705 0.0562225537012771 no 228 0.0605525343229471 404 762535 SGTC_549 1661-1316 519 µM 1.5483590415998 0.0564252217677258 no 229 0.0607679383477911 394 2857282 SGTC_801 0866-0028 10.1 µM 1.54188076646287 0.0571623529695379 no 230 0.0615512853009319 428 6849771 SGTC_1196 1588-0294 184 µM 1.53431947386421 0.0580322783426975 no 231 0.0624755385966942 370 6144269 SGTC_967 1306-0166 352 µM 1.53393738828184 0.0580765118640103 no 232 0.0625225284210235 418 4437607 SGTC_2564 betulinic acid 100 µM 1.53000545650202 0.0585332468048588 no 233 0.0630076891548867 456 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_2621 lithochol-11-enic acid 100 µM 1.52714932342971 0.0588667812895273 no 234 0.0633619421802911 453 6708711 SGTC_2495 cafestol 54.53 µM 1.52344549530688 0.0593015270440979 no 235 0.0638236435624274 397 16667697 An anti-infammatory. SGTC_2029 5175081 200 µM 1.51936310272595 0.0597836199984061 no 236 0.064335562031162 453 1380876 SGTC_862 0452-0056 10.2 µM 1.51830407051782 0.0599091821609682 no 237 0.0644688810047829 381 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_922 1866-0035 480 µM 1.51372883317303 0.0604540117552323 no 238 0.0650473144616822 490 3156169 SGTC_3035 9091303 49.47 µM 1.50691846315884 0.0612721773855616 no 239 0.0659157791382114 371 25237002 SGTC_181 1447-1644 8.07 µM 1.50610039365408 0.0613710356703974 no 240 0.0660207017948618 413 534600 SGTC_2293 7624732 200 µM 1.50521760950522 0.0614778540220927 no 241 0.0661340696302052 386 894453 SGTC_632 0781-2353 4.65 µM 1.4954674990684 0.062667314294268 no 242 0.0673962379666004 462 6811515 YHR007C ERG11 SGTC_2818 7996756 12.99 µM 1.49364559724408 0.062891552314482 no 243 0.0676341374373197 311 2241621 SGTC_3291 9121177 71.43 µM 1.49291446758512 0.0629817146606315 no 244 0.067729788775162 354 17015612 SGTC_737 1950-0117 57.9 µM 1.49150621910652 0.0631556624876229 no 245 0.0679143198194769 424 5393513 SGTC_3290 9121031 71.43 µM 1.48589258324366 0.0638527830271956 no 246 0.0686537678496469 384 17014854 SGTC_2068 5226020 147 µM 1.48550097139633 0.0639016371644587 no 247 0.0687055831345598 477 1810509 SGTC_2445 5742597 35.57 µM 1.48432253602786 0.064048824022256 no 248 0.0688616872134307 412 1774255 SGTC_3159 9100096 49.47 µM 1.48366504492116 0.0641310593010417 no 249 0.0689489020047193 417 25236875 SGTC_2594 a-mangostin 100 µM 1.48150423453729 0.0644018995028077 no 250 0.0692361286764266 467 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_1125 tnp00248 1.32998 µM 1.4800930831478 0.0645792551624323 no 251 0.0694242036107399 539 24207736 SGTC_872 0588-0139 234 µM 1.47998226538763 0.0645931989582915 no 252 0.0694389897877804 460 2047100 SGTC_1955 wogonin 32.4 µM 1.47952086241664 0.0646512807567678 no 253 0.0695005798738219 403 5281703 A flavanone. SGTC_1654 st012436 41.8 µM 1.47504402821736 0.0652169365561426 no 254 0.0701003534231637 375 4323132 SGTC_1774 st048371 48.465 µM 1.47384904907473 0.0653685716741678 no 255 0.0702611193199095 466 4242727 SGTC_991 3996-0057 64.7 µM 1.47110661312015 0.0657176029634815 no 256 0.0706311434390126 434 715343 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 1.46848355674827 0.0660527908254442 no 257 0.0709864597730871 519 688664 SGTC_1687 st020778 55.3625 µM 1.46789108225385 0.0661286833733897 no 258 0.0710669054636879 607 4259299 SGTC_941 3237-0776 460 µM 1.46726012768333 0.0662095792486032 no 259 0.0711526529071484 414 760008 SGTC_469 w7 172 µM 1.46689391283264 0.0662565674876406 no 260 0.0712024583447302 340 45115570 A P450 inhibitor. SGTC_2620 irigenin 100 µM 1.46501717747908 0.0664977727741851 no 261 0.0714581156349451 466 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_1309 pyrazolanthrone 13.4 µM 1.46433706303342 0.0665853513298468 no 262 0.0715509375756638 457 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_1333 1482-0047 286 µM 1.46113522069787 0.0669988535794701 no 263 0.0719891681057017 481 3811116 SGTC_152 4469-0003 551.229 µM 1.46081125640964 0.0670408023843857 no 264 0.0720336229241702 416 697280 SGTC_2385 9074692 200 µM 1.4601495854243 0.0671265425513885 no 265 0.0721244836990797 449 17046906 SGTC_2370 9071495 200 µM 1.45180650996772 0.0682149375051398 no 266 0.0732777066461862 442 21791103 SGTC_2728 chlorpromazine 9.18 µM 1.4376577323638 0.070091784041997 no 267 0.0752655957354334 344 2726 A thorazine and dopamine antagonist. SGTC_699 0375-0592 111 µM 1.43476240749231 0.0704807021104463 no 268 0.0756774068388435 449 762578 SGTC_1803 st050068 52.4 µM 1.43114715271075 0.0709686520983255 no 269 0.076194022889841 675 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_1182 1222-0449 220 µM 1.42774693481815 0.0714299425161459 no 270 0.0766823557864852 447 658318 SGTC_615 k087-0205 167 µM 1.42742349014025 0.0714739422077542 no 271 0.0767289319915618 445 9642773 SGTC_1251 0490-5699 265 µM 1.4185988734952 0.0726824375877518 no 272 0.0780079972482486 528 3883818 SGTC_3239 9133757 49.47 µM 1.41212148118161 0.073579403197873 no 273 0.0789570973671989 425 17036923 SGTC_2464 5717415 7.67 µM 1.41202847380168 0.0735923438782464 no 274 0.078970788692467 500 5285744 SGTC_2308 7584454 197.62 µM 1.41189762022989 0.0736105532748565 no 275 0.0789900542818269 538 893577 SGTC_786 4544-0069 423 µM 1.41151558254871 0.0736637368048321 no 276 0.0790463221110152 500 748821 YLR208W SEC13 SGTC_3002 9075603 71.4286 µM 1.40959262741359 0.0739318778557866 no 277 0.0793300026074709 490 20105405 SGTC_1939 st074455 53.6 µM 1.40954581641647 0.073938414569706 no 278 0.0793369179114801 501 1644229 SGTC_2864 9034755 47.6 µM 1.40817677204061 0.0741297840808056 no 279 0.0795393662448383 468 4930451 SGTC_3321 9137793 26.8275 µM 1.40710037426635 0.074280511986799 no 280 0.0796988135813276 503 4904192 SGTC_2299 7976368 114.88 µM 1.40702512684876 0.0742910576235546 no 281 0.0797099690546716 451 2979718 SGTC_627 1391-0720 175 µM 1.40298847411476 0.0748584563821018 no 282 0.0803101379871726 462 997839 SGTC_799 1310-0557 151 µM 1.39975593912244 0.0753152059505893 no 283 0.080793208093813 491 5354492 SGTC_1734 st037168 69.4 µM 1.39836200016949 0.0755128205471973 no 284 0.0810021941100298 471 708907 SGTC_198 3454-2873 16.191 µM 1.39782350414722 0.0755892672468241 no 285 0.0810830371839376 466 710957 SGTC_1162 k048-0130 20.1 µM 1.39475935739144 0.0760253865983765 no 286 0.0815442093267263 476 6797406 SGTC_3198 9112019 49.47 µM 1.39228641690322 0.0763787545029301 no 287 0.0819178415266697 469 45595555 SGTC_2130 NSC 7 2.4545 µM 1.39218346026272 0.0763934934223584 no 288 0.0819334249904605 514 21448 SGTC_290 2043-6722 48.1 µM 1.38825441046861 0.0769575812113033 no 289 0.0825297945943265 483 773758 YLR208W SEC13 SGTC_1338 1486-1223 76 µM 1.3867293710362 0.0771773797600324 no 290 0.082762150489932 520 3444526 SGTC_377 3970-0964 33.1 µM 1.38493473910398 0.0774366442657845 no 291 0.0830362117274767 593 16481235 SGTC_161 4065-0411 162.148 µM 1.37820686598783 0.0784144879600184 no 292 0.0840697140040047 566 1906281 YLR208W SEC13 SGTC_1382 3002-2117 298 µM 1.37806405741837 0.0784353450713572 no 293 0.0840917557422851 506 1497314 SGTC_182 3448-4371 550.524 µM 1.37791257619701 0.078457473415248 no 294 0.0841151407993832 514 3491403 SGTC_1610 st001799 48.1 µM 1.37513023394699 0.0788647596597871 no 295 0.0845455362996596 415 621897 SGTC_762 1165-0429 115 µM 1.3740718889092 0.0790201026830447 no 296 0.0847096827716629 500 5967793 SGTC_702 1488-0190 94 µM 1.37299491578544 0.0791784177117975 no 297 0.0848769636369963 475 949357 SGTC_964 1287-0107 19.4 µM 1.37002469685198 0.0796162843135113 no 298 0.0853395962100396 545 51516812 YPR165W RHO1 SGTC_29 0299-0004 12.984 µM 1.36953799290851 0.0796882080690681 no 299 0.0854155835713815 396 16871 A napthoquinone isolated from Swertia calycina. SGTC_2601 securinine 100 µM 1.36856306532454 0.0798324279853736 no 300 0.0855679479715339 486 442872 A GABA receptor antagonist. SGTC_2265 7929201 200 µM 1.36296698670779 0.0806640704072278 no 301 0.0864464576522553 509 1265108 SGTC_3264 9137442 49.47 µM 1.35551854242245 0.0817811243816135 no 302 0.0876262024822298 470 17015726 SGTC_2211 7117706 200 µM 1.35406516370392 0.0820004428098243 no 303 0.0878577945124549 474 822771 SGTC_990 3985-0011 41.3 µM 1.35194545012856 0.0823211069087138 no 304 0.0881963832456957 450 5399565 YGL099W LSG1 SGTC_2872 9044037 25.97 µM 1.34807394214442 0.0829092133256901 no 305 0.0888173007692253 435 6465195 SGTC_935 2996-0153 430 µM 1.34676209501718 0.0831092064305539 no 306 0.0890284331451303 500 23738523 SGTC_916 4466-0038 42 nM 1.34374041424457 0.0835712462160096 no 307 0.0895161718436378 658 5722064 YGL116W CDC20 SGTC_3078 9116413 49.47 µM 1.34162434253632 0.0838959582570363 no 308 0.0898589146440798 469 17177322 SGTC_827 3253-0474 693 µM 1.34080726750168 0.0840215919881085 no 309 0.0899915180155781 542 5402065 SGTC_671 0560-0003 407 µM 1.33809883412444 0.0844390518295038 no 310 0.0904321103908958 491 3238678 SGTC_1039 k821-0043 94 µM 1.33690848065856 0.0846230164671303 no 311 0.0906262561220858 525 15992768 SGTC_97 0535-0701 19.132 µM 1.335690103845 0.0848116231556144 no 312 0.0908252926543939 483 2832013 YGL099W LSG1 SGTC_1502 4534-4282 27.7 µM 1.3356566932121 0.0848167996117764 no 313 0.0908307552494004 483 3278949 SGTC_1117 retinoic acid 1.10837 µM 1.33527015344042 0.084876705142502 no 314 0.0908939717251265 570 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_2652 actinonin 100 µM 1.33423903772105 0.0850366615455539 no 315 0.0910627647574921 473 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_51 1013-0126 23.419 µM 1.33254315810171 0.0853002336260317 no 316 0.0913408847044992 494 1627850 SGTC_111 0083-0039 52.457 µM 1.33187444852037 0.0854043319436927 no 317 0.0914507243122861 360 759313 SGTC_1394 3474-0001 65.7 µM 1.32996374509541 0.0857022963509171 no 318 0.0917651084169419 468 5017666 YIL048W NEO1 SGTC_154 3389-1638 511.116 µM 1.32909175424472 0.0858385372047209 no 319 0.0919088501838094 464 5238686 SGTC_2421 5690543 90.72 µM 1.32891167747279 0.0858666927905907 no 320 0.0919385553791597 517 3397993 SGTC_3016 9080866 49.47 µM 1.32575084183743 0.0863620257112225 no 321 0.0924611203701046 559 17066299 SGTC_875 0709-0210 25.7 µM 1.32037039259281 0.0872101024839939 no 322 0.0933556918641508 578 6251364 SGTC_1089 terbinafine 2.25 µM 1.31938718814882 0.0873657467838199 no 323 0.0935198513720385 510 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_110 0850-0284 111.64 µM 1.31920632516673 0.0873944005187285 no 324 0.0935500721361441 397 3906265 SGTC_1822 st052468 42 µM 1.31753895270808 0.0876588892698155 no 325 0.0938290165791675 501 2873678 SGTC_347 4534-1311 26.2 µM 1.30979936350314 0.0888944135284716 no 326 0.0951318592688613 529 2862016 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 1.30898166751045 0.0890257014829105 no 327 0.0952702803491911 520 803109 SGTC_190 3970-0790 3.722 µM 1.30676825734889 0.0893818070779995 no 328 0.0956457143971713 493 2832352 SGTC_1780 st038448 24.544 µM 1.30598763228164 0.0895076507461694 no 329 0.0957783817361686 537 728868 YDL195W SEC31 SGTC_27 0485-0001 32.618 µM 1.30385905237883 0.0898514661223628 no 330 0.0961408219230074 417 2054479 SGTC_1433 4060-0023 7.6 µM 1.30186934885573 0.090173736443007 no 331 0.0964805260222956 563 3840627 SGTC_2282 7944268 200 µM 1.30172124909363 0.0901977583060695 no 332 0.0965058464650158 575 2970414 SGTC_1951 sophoraflavanone G 9.2 µM 1.3016577248858 0.0902080634242124 no 333 0.0965167086204085 594 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_299 1273-0059 1.44 µM 1.29708684434644 0.0909518650035954 no 334 0.0973006537597373 533 2848077 SGTC_672 1441-0018 53.7 µM 1.29568145115548 0.0911814711500029 no 335 0.0975426272044089 519 251141 SGTC_378 3970-0959 8.33 µM 1.29464208272097 0.0913515542801625 no 336 0.0977218640389252 551 6615653 SGTC_2487 5918373 44.05 µM 1.29197715260866 0.0917887201237367 no 337 0.098182528484534 563 2876279 SGTC_1455 4262-0120 131 µM 1.29179786743869 0.0918181863247519 no 338 0.0982135770456029 567 1529587 SGTC_2306 7482397 179.52 µM 1.29039234378602 0.0920494323112411 no 339 0.0984572345222126 562 891448 SGTC_2467 5474540 200 µM 1.28805524802249 0.0924349008690617 no 340 0.098863365994412 554 5413519 SGTC_712 r015-0009 80.6 µM 1.28476337885707 0.0929798689944923 no 341 0.0994374915552121 491 6813872 YLR060W FRS1 SGTC_1266 0828-0227 32.9 µM 1.28098631339144 0.0936080830621297 no 342 0.100099236743915 519 3913820 SGTC_2758 dehydroepiandrosterone 69.35 µM 1.28067245663467 0.0936604254614048 no 343 0.100154369068976 606 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_1995 st072814 61.1 µM 1.28066837470412 0.0936611063538969 no 344 0.100155086250113 535 5769371 SGTC_1773 st048542 73.5835 µM 1.27989219367104 0.0937906448154863 no 345 0.100291526728374 577 3237138 SGTC_1257 0669-0121 16 µM 1.27924647328513 0.0938985111678049 no 346 0.100405137600746 624 4307855 SGTC_1246 0422-0085 105 µM 1.27785080890948 0.0941319669881543 no 347 0.100651017706049 612 264295 SGTC_1156 4092-0367 4.88 µM 1.27580916157716 0.0944742487529737 no 348 0.101011494090738 576 1357585 SGTC_123 0083-0120 66.675 µM 1.27565028925451 0.0945009220983879 no 349 0.101039584246289 588 16001701 SGTC_2858 9025781 8.96 µM 1.2750452353207 0.0946025564747177 no 350 0.101146615739456 691 4894980 YPL153C RAD53 SGTC_2673 kobusone 100 µM 1.2739886191036 0.094780235532423 no 351 0.101333724794694 535 6710676 An epoxy ketone and protein crosslinker. SGTC_1722 st034304 3.6505 µM 1.27340888143398 0.0948778278012455 no 352 0.101436493710283 581 4036148 YLR033W RSC58 SGTC_1450 4112-4260 37.6 µM 1.27226311754035 0.0950709218945899 no 353 0.101639824184967 582 1633175 SGTC_1707 st032323 6.317 µM 1.26997896774515 0.0954567300873746 no 354 0.102046061050181 600 3132057 YMR211W DML1 SGTC_1423 4048-0112 5.59 µM 1.26854812227833 0.0956989957967198 no 355 0.102301138526994 568 X1423 SGTC_2722 naftopidil 47.16 µM 1.26850431377753 0.0957064204283508 no 356 0.102308955598251 591 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_2924 9010168 62.78 µM 1.26709819767956 0.0959449530756881 no 357 0.102560089971383 586 2993929 SGTC_2187 6125751 200 µM 1.26429903413355 0.0964211023755639 no 358 0.103061358071607 584 874498 SGTC_2952 9073731 13.78 µM 1.26300649173556 0.096641554267049 no 359 0.103293423363962 612 16457353 SGTC_2120 5538279 151.968 µM 1.26225077182209 0.0967706188258783 no 360 0.103429282253852 568 2058197 SGTC_1885 st057546 99.9 µM 1.26129663501826 0.0969337504682628 no 361 0.103600996564517 601 702008 SGTC_1625 st003711 30.1 µM 1.26027913079972 0.0971079385822024 no 362 0.103784342827544 556 24207034 YER133W GLC7 SGTC_773 4358-1457 44.6 µM 1.25909730052552 0.0973105461755521 no 363 0.103997594684927 635 1186886 SGTC_461 N-acetylfarnesylcysteine 136 µM 1.25848812633586 0.0974151012732782 no 364 0.104107639333623 506 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_2379 9035213 200 µM 1.25513845831447 0.0979914913487009 no 365 0.104714250761125 627 646551 SGTC_2190 6049624 200 µM 1.25452917543476 0.0980966010459437 no 366 0.104824864044007 501 2265554 SGTC_2001 4023502 57.655 µM 1.25167130742577 0.0985907252223137 no 367 0.105344829681551 589 108941 YCR052W RSC6 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 1.24894506789515 0.0990637866295182 no 368 0.105842583112811 470 1241132 A phosphatase inhibitor. SGTC_1537 2',6'-dihydroxyflavanone 78 µM 1.24835230641455 0.0991668629162119 no 369 0.105951033390319 625 5106787 A p450 inhibitor. SGTC_1392 3455-1037 33.9 µM 1.24826848476941 0.0991814451299018 no 370 0.105966375684105 588 981132 SGTC_2511 berberine 10.47 µM 1.24436995617879 0.0998613945875427 no 371 0.10668171750097 576 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_502 l-744,832 89.3 µM 1.24409454391131 0.0999095581890359 no 372 0.106732384442243 595 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_2729 fluphenazine 10.66 µM 1.23585194194449 0.101358870904078 no 373 0.108256801734533 591 3372 An atypical antipsychotic. SGTC_450 aminopyrene 156 nM 1.23578375658498 0.101370923607312 no 374 0.108269477202389 605 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_915 methyl methanesulfonate (MMS) 110 mM 1.22567331658168 0.103169656890229 no 375 0.110160817721923 600 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_2918 7977171 22.06 µM 1.22316606043098 0.103619284111104 no 376 0.110633490845004 567 2236483 SGTC_3133 9127736 49.47 µM 1.2226820296765 0.103706249032175 no 377 0.110724908471384 622 27243420 SGTC_2628 lathosterol 100 µM 1.22185234279874 0.103855440513052 no 378 0.110881735162531 611 6710616 SGTC_3079 9117512 49.47 µM 1.21948192460798 0.104282538656441 no 379 0.11133066612892 614 7185044 SGTC_886 0866-0150 153 µM 1.21152630128857 0.105725273412001 no 380 0.112846880398493 646 271463 SGTC_1024 4507-0395 26 µM 1.21066329637863 0.10588264078968 no 381 0.113012237362592 584 4201836 SGTC_2699 st077704 54.6 µM 1.2101126760548 0.105983133828367 no 382 0.11311782987233 589 645852 SGTC_1849 st056239 19.2 µM 1.20669690307982 0.106608082545571 no 383 0.113774446097862 625 5393181 SGTC_1052 3253-3998 198 µM 1.20463440957194 0.106986721305252 no 384 0.114172233493316 659 5450317 SGTC_1914 st062367 72.6 µM 1.20342384900824 0.107209410927664 no 385 0.114406171752116 588 978205 SGTC_2795 7780010 54.55 µM 1.20285954655711 0.107313331765046 no 386 0.114515338539137 574 953673 SGTC_641 4092-0595 30 µM 1.20232508335887 0.107411824407857 no 387 0.114618801140667 646 786260 SGTC_3050 9093513 49.47 µM 1.20025950597745 0.10779308833099 no 388 0.115019285625737 610 25236664 SGTC_2734 clemastine 41.6 µM 1.20014848396231 0.107813608326187 no 389 0.115040839275582 461 26987 Clemastine is a selective histamine H1 antagonist. SGTC_2375 9072683 200 µM 1.19767468756694 0.108271565599138 no 390 0.115521843635768 691 16798029 SGTC_375 3970-0961 9.27 µM 1.19743540139543 0.108315937185391 no 391 0.115568446063242 621 2898222 SGTC_2799 7812892 81.82 µM 1.19690218386848 0.108414860453912 no 392 0.115672341437075 663 20205235 SGTC_298 1391-0729 10 µM 1.18938110980082 0.109817110743069 no 393 0.117144865424027 596 3237558 SGTC_2469 5655019 90.81 µM 1.18762561762735 0.110146275205524 no 394 0.11749047022699 664 2788239 SGTC_54 0159-0055 9 µM 1.1870021755609 0.110263344164191 no 395 0.117613381184807 622 3319099 SGTC_45 0kpi-0036 14.9 µM 1.18227354247725 0.111154185305279 no 396 0.118548590027159 587 2795021 SGTC_2179 6298986 200 µM 1.18107120812459 0.11138151615042 no 397 0.118787218283785 612 738374 SGTC_2934 9036370 36.88 µM 1.17656878857398 0.112235765131073 no 398 0.11968383072786 672 6462800 SGTC_1294 1000-1494 117 µM 1.17356980180402 0.112807358130825 no 399 0.120283691422406 619 712797 YDL207W GLE1 SGTC_3331 9141060 1.957 µM 1.17337655076139 0.112844262033236 no 400 0.120322418223781 598 4906567 YPR165W RHO1 SGTC_2552 juarezic acid 87.02 µM 1.17300217077407 0.112915779479568 no 401 0.12039746759061 743 1549512 SGTC_3249 9135183 49.47 µM 1.17173867873322 0.113157381976077 no 402 0.120650994485795 671 4902779 SGTC_167 3672-0051 66.205 µM 1.17083040519033 0.113331288009383 no 403 0.120833476813232 593 3237971 SGTC_1284 0929-0043 16 µM 1.170313830161 0.113430281007452 no 404 0.120937349135299 658 1239883 SGTC_2905 7799065 20.05 µM 1.16851319468216 0.113775824862855 no 405 0.121299910035345 613 1296806 SGTC_2603 homopterocarpin 100 µM 1.16703953602485 0.114059179265847 no 406 0.12159720183596 656 101795 A weak amylase inhibitor. SGTC_3140 9094243 49.47 µM 1.16589697540761 0.114279216004222 no 407 0.121828051009447 663 19291112 SGTC_3195 9113082 49.47 µM 1.1655816779258 0.114339989840649 no 408 0.121891809601947 631 17018038 SGTC_1832 st054113 55 µM 1.16301337016396 0.114835890447777 no 409 0.122412038917002 619 1251267 SGTC_1140 3229-1848 2.98 µM 1.16193224780415 0.115045095426752 no 410 0.122631493427735 659 2849525 SGTC_2867 9039098 71.43 µM 1.15594832247243 0.116207930019815 no 411 0.123851147716961 655 6463460 SGTC_3256 9138902 49.47 µM 1.15456978746677 0.116476993735853 no 412 0.124133322414912 676 17228773 SGTC_1395 3486-0190 4.35 µM 1.15443205517263 0.116503900710757 no 413 0.124161539769004 697 6748079 SGTC_2583 asiatic acid 100 µM 1.15428219535853 0.116533181889871 no 414 0.124192246797364 634 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 1.15340684764417 0.116704320774625 no 415 0.12437171608302 717 6708784 An antioxidant flavonoid SGTC_1127 asiatic acid 681.4 nM 1.15333651558546 0.116718079097666 no 416 0.124386143871044 636 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_230 MPP+ 141.667 µM 1.15314405173894 0.116755734660649 no 417 0.12442563153101 627 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_1404 3909-7820 48.3 µM 1.15163974121493 0.117050349858622 no 418 0.124734571784814 648 23741373 SGTC_2420 aureobasidin a 50 nM 1.15104588428754 0.117166800053476 no 419 0.124856679646061 707 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_2164 5685496 200 µM 1.15010856466328 0.117350767267588 no 420 0.12504957963112 695 759046 SGTC_2 0422-0095 29 µM 1.14957237808466 0.117456096250581 no 421 0.125160020152808 544 6790840 SGTC_1136 pergolide 1.05886 µM 1.1484132622707 0.117684022748981 no 422 0.125399000662314 761 47811 A dopamine receptor agonist. SGTC_2142 5622915 118.518 µM 1.14740154053989 0.117883221652996 no 423 0.125607852402206 624 5322196 SGTC_2643 anethole 100 µM 1.14732068764061 0.117899151149305 no 424 0.125624553494918 697 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 1.1456952167139 0.118219721696753 no 425 0.125960641858772 650 6710655 SGTC_1982 st072467 71.9 µM 1.14126209839834 0.119097139259316 no 426 0.12688043474644 726 3163533 SGTC_946 3434-1334 87.4 µM 1.14108159623245 0.119132962001253 no 427 0.126917984531413 637 4047976 SGTC_3258 9138477 49.47 µM 1.13939308401145 0.119468435195857 no 428 0.127269619629287 664 4970355 SGTC_19 0279-0214 38.434 µM 1.13868908096466 0.119608503037107 no 429 0.127416429281253 764 3566274 YBR002C RER2 SGTC_2776 terbinafine 19.92 µM 1.13747784680051 0.119849760146467 no 430 0.127669290194768 644 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_887 0885-0007 9.62 µM 1.13685004295524 0.119974942837744 no 431 0.127800489597248 693 5719458 SGTC_2275 7947463 200 µM 1.13450234122859 0.120443886000102 no 432 0.128291946114713 638 1225414 SGTC_1304 1165-0502 251 µM 1.13361472054635 0.120621520214763 no 433 0.128478097751393 720 767425 SGTC_132 0417-1715 25.805 µM 1.13343831551443 0.120656845058197 no 434 0.128515115702218 708 6769098 SGTC_716 1683-5115 658 µM 1.12860891282363 0.121626755868379 no 435 0.129531424587346 768 723597 SGTC_2115 tiliquinol 12.7705 µM 1.12538090797564 0.122278098199922 no 436 0.130213828924082 669 71208 A bioactive hydroxyquinoline. SGTC_2219 9098279 200 µM 1.12510739356332 0.122333399869021 no 437 0.130271764323378 658 902349 SGTC_3243 9134147 49.47 µM 1.12447669798255 0.122460986629225 no 438 0.130405425251351 717 24282180 SGTC_930 2810-3379 265 µM 1.11871451070826 0.123630974670528 no 439 0.13163097634058 779 1015764 SGTC_3167 9103034 49.47 µM 1.11721129288583 0.123937479919757 no 440 0.131951996611295 637 5127859 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 1.11657776297053 0.124066815471691 no 441 0.1320874519522 632 279621 SGTC_1453 4237-0541 195 µM 1.11641086150094 0.124100904228596 no 442 0.132123153188851 714 739892 SGTC_1082 camptothecin 424.86 nM 1.11480196848634 0.124429848341467 no 443 0.132467646374385 606 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_3022 9087993 49.47 µM 1.11212219235538 0.124979090947507 no 444 0.133042808048166 669 17173644 SGTC_1723 st034307 2.5525 µM 1.11120364536773 0.12516774402033 no 445 0.133240351251759 685 867466 SGTC_806 3966-4455 5.86 µM 1.11053731514482 0.125304720684063 no 446 0.133383778831502 615 714982 SGTC_883 0850-0245 24.6 µM 1.10984757624163 0.125446619634569 no 447 0.133532356963751 728 6823229 YPR165W RHO1 SGTC_2730 imipramine 71.33 µM 1.10821105051708 0.125783748253021 no 448 0.133885339751756 818 3696 A tricyclic antidepressant. SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 1.10274767812331 0.126913791758414 no 449 0.135068377725667 685 1609 A potent and irreversible inhibitor of serine proteases. SGTC_227 fluconazole 33.516 µM 1.10262779038906 0.126938668316031 no 450 0.135094418332066 747 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_940 3232-1287 54.8 µM 1.10055699067509 0.12736889240268 no 451 0.135544756486295 725 1585493 YIL048W NEO1 SGTC_2314 7727897 200 µM 1.09937339615538 0.127615247975676 no 452 0.135802615004642 680 900724 SGTC_103 0844-0104 51.839 µM 1.0988432877167 0.127725693076555 no 453 0.135918213562685 802 5375804 SGTC_2625 euphol 100 µM 1.09817341413997 0.127865352454454 no 454 0.136064386463803 751 6708538 A triterpene alcohol. SGTC_1048 3161-0300 24.5 µM 1.09478107944341 0.128574236566721 no 455 0.136806278739623 725 2165101 SGTC_3322 9139058 2.11 µM 1.09052595210075 0.129467265345284 no 456 0.137740763882818 735 4908926 YPR165W RHO1 SGTC_1765 st044815 90.4 µM 1.09046249031387 0.129480616593757 no 457 0.137754733860657 693 645695 SGTC_2627 acetyl isogambogic acid 100 µM 1.08848943500395 0.129896188813511 no 458 0.138189549054708 660 6857789 A caspase activator and apoptosis inducer. SGTC_705 1124-0212 310 µM 1.08301015360246 0.131055094850917 no 459 0.139401958120655 735 9554485 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 1.08221091795003 0.131224733844658 no 460 0.13957940912195 764 5393153 SGTC_418 lividomycin a 100 µM 1.08043805531363 0.131601567780498 no 461 0.139973578611807 769 72394 An antibiotic. SGTC_1702 st027038 51 µM 1.08030986608962 0.13162884419094 no 462 0.140002108863987 736 5521182 SGTC_1583 clindamycin 39.6 µM 1.07590670155888 0.132568129377709 no 463 0.140984492239591 659 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_464 bw-b 70c 158 µM 1.07294015699373 0.133203551640762 no 464 0.141648983535332 772 5353454 SGTC_654 1124-0271 80.9 µM 1.07085102692339 0.133652290885542 no 465 0.142118209492709 744 5403748 SGTC_2349 9023730 187.07 µM 1.07055987214796 0.133714912537123 no 466 0.142183687308013 719 4126287 SGTC_562 3772-2733 112 µM 1.06619439727883 0.134656259034181 no 467 0.14316788716256 821 2876874 YIL048W NEO1 SGTC_2085 5307070 144.047 µM 1.06477499911585 0.134963307538557 no 468 0.143488880667458 678 2840351 SGTC_1315 1237-0019 3.69 µM 1.06196583317847 0.135572409674399 no 469 0.144125598177351 774 825140 SGTC_2664 lyso-paf C-16 73.48 µM 1.0618391037667 0.135599932321192 no 470 0.14415436714339 784 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_1367 1812-0510 76.9 µM 1.06096681645339 0.1357894764537 no 471 0.144352490966866 735 1142582 YDR527W RBA50 SGTC_798 1287-0182 476 µM 1.06090843137297 0.135802169746489 no 472 0.144365758600804 809 1649755 SGTC_754 3474-0146 171 µM 1.05997105695271 0.136006072242184 no 473 0.144578883429231 686 24762078 SGTC_1884 5633444 25 µM 1.0575031802259 0.136543899343773 no 474 0.145141001989794 757 5724239 SGTC_559 1550-0661 158 µM 1.05737203466625 0.136572520685287 no 475 0.145170914660762 744 5830875 SGTC_2330 7979373 200 µM 1.05737160681127 0.136572614067511 no 476 0.14517101225595 736 1863007 SGTC_349 k015-0014 24 µM 1.05549738007249 0.136982095734319 no 477 0.145598953545264 689 2196908 SGTC_546 peri-Naphthalide 147 µM 1.05151953255771 0.137853954775807 no 478 0.146510021631177 748 223824 A penicillin ester. SGTC_1807 st050092 58.9 µM 1.05088764529507 0.13799279863364 no 479 0.146655097664421 714 5008496 SGTC_187 1488-2104 32.728 µM 1.05088610314612 0.137993137604879 no 480 0.146655451846808 777 2852859 SGTC_2249 haloperidol 116.36 µM 1.04869474348931 0.138475382113281 no 481 0.147159317161092 862 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_3032 9089427 49.47 µM 1.04464403772251 0.139369826605808 no 482 0.148093759136903 724 17173707 SGTC_1847 st056231 15 µM 1.04452213018283 0.139396806041518 no 483 0.148121942939676 807 5393180 SGTC_1785 bathophenanthroline 24 µM 1.04313254012936 0.139704588174968 no 484 0.148443455875352 738 72812 An iron chelator. SGTC_2947 9072639 7.68 µM 1.04224002596553 0.139902515816608 no 485 0.148650205084893 806 16488146 SGTC_976 1348-1067 47.6 µM 1.04169093720726 0.140024378662964 no 486 0.148777496050854 817 5310671 YGL099W LSG1 SGTC_1993 st073995 70.8 µM 1.03871709934866 0.140685634834809 no 487 0.149468163123899 783 3098394 SGTC_1307 1187-1599 12.2 µM 1.03695167444375 0.141079191808297 no 488 0.149879189771833 766 1538471 SGTC_863 0466-0191 129 µM 1.0358476914303 0.141325676049951 no 489 0.150136602092412 811 765160 YPR165W RHO1 SGTC_2055 5235184 200 µM 1.033571522543 0.141834792940349 no 490 0.150668259064835 753 2836034 SGTC_910 3454-3003 490 µM 1.03257310888273 0.142058502239328 no 491 0.150901858993253 782 820824 SGTC_2709 st078560 56 µM 1.0317456152515 0.142244095302554 no 492 0.151095651184371 790 17250903 SGTC_2984 9022109 38.96 µM 1.02833100321184 0.143011670852774 no 493 0.151897076027948 755 6459207 SGTC_2403 6032726 181.2 µM 1.02584179312182 0.14357298456651 no 494 0.152483081397461 737 2881040 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 1.02461141808032 0.143850981016282 no 495 0.152773287389235 781 2333 A French combination drug. SGTC_605 1315-0399 119 µM 1.02439868666705 0.14389908330079 no 496 0.152823501022317 815 24020461 SGTC_2475 5812728 15.03 µM 1.02294940742322 0.14422707936539 no 497 0.153165883624742 805 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_1553 gossypol 38.6 µM 1.02193362010396 0.1444572691684 no 498 0.153406159422046 689 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2990 9074105 71.4286 µM 1.02147533166193 0.144561203920361 no 499 0.153514645323187 749 6502001 SGTC_2192 5915882 198.485 µM 1.01914614457002 0.145090216368582 no 500 0.154066794950216 739 2876149 SGTC_114 0364-0001 490.298 µM 1.01646453016009 0.145700884900356 no 501 0.15470411496606 780 4003655 SGTC_1800 st050079 29.0735 µM 1.01263702272887 0.146575490167285 no 502 0.155616784551055 890 3645560 SGTC_663 1486-0733 13.9 µM 1.01259304669933 0.146585559349309 no 503 0.155627291234411 821 722445 YPR165W RHO1 SGTC_3172 9105863 49.47 µM 1.01234616423757 0.146642096592152 no 504 0.155686284687662 744 2348785 SGTC_1534 6-azauridine 81.6 µM 1.0106150669697 0.147038936992956 no 505 0.15610035081839 843 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_540 1187-0821 17.3 µM 1.0091290566239 0.147380167045577 no 506 0.156456372226954 778 847520 SGTC_1312 1218-2183 165 µM 1.00786998661304 0.147669700137252 no 507 0.156758440924304 826 6744073 SGTC_1841 st054148 70 µM 1.00717417309595 0.147829871280685 no 508 0.156925540982791 732 675442 SGTC_326 k292-0812 17.5 µM 1.00571378329597 0.148166420392705 no 509 0.157276635473902 784 3579357 SGTC_1384 3089-0840 101 µM 1.00449146314384 0.148448499803778 no 510 0.157570891999084 763 1069836 SGTC_821 1114-0266 29.2 µM 1.00403712077609 0.148553441595318 no 511 0.157680360748016 774 3123235 SGTC_3180 9109287 49.47 µM 1.00203764440582 0.149015860290859 no 512 0.158162705968507 745 18891271 SGTC_452 diindolylmethane 8 µM 1.00063791933272 0.149340146160956 no 513 0.158500945362244 733 3071 Inhibits expression of several cancer promoting factors. SGTC_1281 0884-0031 11.8 µM 1.00037028693545 0.149402204383258 no 514 0.158565671922 816 1548255 SGTC_510 ag-490 170 µM 0.999573346610816 0.149587099719084 no 515 0.158758513584498 873 5328779 SGTC_1735 st034310 56.75 µM 0.998268440776429 0.149890175922799 no 516 0.159074603321241 790 871153 SGTC_564 3555-0129 330 µM 0.996448183032454 0.150313630892013 no 517 0.159516215932437 730 563260 SGTC_145 3737-0113 38.366 µM 0.990564632092244 0.151687796568192 no 518 0.160949107443219 928 6849351 SGTC_1202 1988-0068 29.6 µM 0.990218328503415 0.151768938802299 no 519 0.161033707897748 807 2850480 SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.98948002981673 0.151942025506044 no 520 0.161214167913675 828 94937 An inhibitor of serotonin biosynthesis. SGTC_920 mycophenolic acid 780.421 nM 0.988824450471269 0.152095829365638 no 521 0.161374519646228 783 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_774 k060-0086 136 µM 0.988778180469432 0.15210668856189 no 522 0.161385841007154 897 5911235 SGTC_1113 artemisinin 1.17947 µM 0.988145734205572 0.152255170214354 no 523 0.16154064011603 862 2240 An anti-malaria and mitochondrial poison. SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.986382308912244 0.152669683872815 no 524 0.161972771523278 853 6708561 SGTC_2138 5575593 77.673 µM 0.983821599302596 0.153272940115996 no 525 0.162601618671174 799 762213 SGTC_662 k832-1615 104 µM 0.983729543924764 0.153294656045163 no 526 0.162624254740186 793 5878478 SGTC_2814 7977482 42.97 µM 0.981030127610797 0.153932356608776 no 527 0.163288942392096 872 6456762 SGTC_425 3825-7017 13.1 µM 0.979089008393042 0.154392003258368 no 528 0.163768001066887 852 3397440 SGTC_3194 9111903 49.47 µM 0.971298389892424 0.156245900945397 no 529 0.165699855177688 802 17087251 SGTC_3225 9130819 49.47 µM 0.968514687136894 0.156911867498024 no 530 0.166393693763268 842 4547121 SGTC_794 k038-0031 316 µM 0.968113701627663 0.157007951992807 no 531 0.166493793851417 901 6624242 SGTC_1922 5578187 25 µM 0.967691390175348 0.157109188464926 no 532 0.166599259667013 792 1350412 SGTC_3340 9146634 11.102 µM 0.965886492425468 0.157542342136586 no 533 0.167050491049124 834 4907387 SGTC_2753 fluvastatin 17.09 µM 0.964659408235485 0.157837275217554 no 534 0.167357716419906 844 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_1361 1608-0041 5.61 µM 0.964231659336829 0.157940171026124 no 535 0.167464897550276 845 X1361 SGTC_761 k216-0224 480 µM 0.963618728812353 0.158087689381408 no 536 0.167618556751087 911 1340404 SGTC_1038 k292-0204 154 µM 0.961784715553435 0.158529634436207 no 537 0.168078878655013 776 4454212 SGTC_1904 st060225 78 µM 0.960225064208454 0.158906102984331 no 538 0.168470977450882 834 66595 SGTC_2592 piperlongumine 83.33 µM 0.959083090369346 0.159182123810614 no 539 0.168758444134502 781 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_3253 9135987 49.47 µM 0.958076921743954 0.159425579918963 no 540 0.169011985910339 794 4182430 SGTC_1408 3909-7976 48.8 µM 0.957957653386419 0.159454454663349 no 541 0.169042056240137 882 24152374 SGTC_2131 toluylene red 5.2905 µM 0.955286169293719 0.1601021152846 no 542 0.169716499896255 818 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_193 1273-0060 1.558 µM 0.953869133688475 0.160446351117358 no 543 0.170074944662666 736 2847393 YHR072W ERG7 SGTC_3294 9122953 26.2835 µM 0.953162274692937 0.160618246711238 no 544 0.170253928690396 865 16459826 SGTC_259 usnic acid 108.925 µM 0.95263515633729 0.160746510829386 no 545 0.170387479044605 868 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_597 k018-0003 82.8 µM 0.952468537008236 0.160787068348214 no 546 0.170429707559452 940 6786234 SGTC_100 0086-0128 49.5915 µM 0.952281549506503 0.160832591726311 no 547 0.170477106227788 887 93297 SGTC_1574 spiramycin 23.7 µM 0.952117009790346 0.16087265699798 no 548 0.170518821683857 846 6419898 An antibiotic and protein synthesis inhibitor. SGTC_3350 9150499 3.57 µM 0.950333660854754 0.161307318816234 no 549 0.17097137018173 891 4910996 YPR165W RHO1 SGTC_1788 fluconazole 20 µM 0.948602167648756 0.161730073908535 no 550 0.171411494062488 798 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_856 0433-0016 11.3 µM 0.947100446519822 0.162097312856021 no 551 0.17179379861761 861 3911780 SGTC_1359 1582-0056 520 nM 0.945930984953604 0.162383675093874 no 552 0.172091894200446 905 3661189 SGTC_472 calcifediol 10 µM 0.945508573069996 0.162487190610236 no 553 0.172199648042056 791 5283731 A vitamin D metabolite. SGTC_1663 st014140 55.4 µM 0.945384011033909 0.162517723761183 no 554 0.172231431024229 998 4207120 SGTC_3106 9121286 49.47 µM 0.944067536831579 0.162840651473178 no 555 0.172567568573211 814 15943471 SGTC_2719 novobiocin 32.65 µM 0.943852756168586 0.162893376177908 no 556 0.172622448542443 816 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_1616 st002734 56.1 µM 0.943605948671307 0.162953976586343 no 557 0.172685525630021 885 4026101 SGTC_1772 st048439 82.2 µM 0.941700381387932 0.163422357519857 no 558 0.173173029868613 844 2927068 YDL195W SEC31 SGTC_998 3996-0085 177 µM 0.941346478472419 0.163509441650072 no 559 0.173263665816234 924 715391 SGTC_1507 4075-3230 155 µM 0.939067203495687 0.164071019849182 no 560 0.173848120745757 801 659771 SGTC_1391 3442-0225 151 µM 0.938980642412544 0.164092371796518 no 561 0.173870341546732 838 5227075 SGTC_1249 0481-0015 10.2 µM 0.937764108279058 0.164392643877628 no 562 0.174182824938873 818 4227577 SGTC_2269 7935389 174.42 µM 0.936410403009302 0.164727191789911 no 563 0.174530961893865 822 97605 SGTC_2875 9039966 71.43 µM 0.936256114108617 0.164765349953596 no 564 0.174570668926028 878 6463691 SGTC_2733 amorolfine 100 µM 0.934319689428972 0.165244746235543 no 565 0.175069505393096 826 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_219 mitoxanthrone 164.414 µM 0.932232862273937 0.165762386875419 no 566 0.175608097876072 825 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_2607 solasodine 47.35 µM 0.931354535109275 0.165980570394948 no 567 0.17583510033807 868 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_1752 st044819 83.042 µM 0.924834095410006 0.167606099310413 no 568 0.177526106145766 829 441209 YML126C ERG13 SGTC_987 1497-1013 404 µM 0.924751060398966 0.167626865628818 no 569 0.177547706358195 878 1676435 SGTC_445 e6 berbamine 66 µM 0.924501840711295 0.167689203208818 no 570 0.177612546780973 949 6610268 A calcium/calmodulin antagonist. SGTC_3053 9095903 49.47 µM 0.924289040015337 0.167742443083355 no 571 0.17766792376349 921 17174018 SGTC_1354 1498-1681 81 µM 0.923668878518524 0.167897661230626 no 572 0.177829370103704 936 5754243 SGTC_584 0986-0246 15.4 µM 0.923434123589664 0.167956441372995 no 573 0.177890507876813 971 53315 YDR232W HEM1 SGTC_897 1000-0139 31.4 µM 0.923189656025878 0.168017667533285 no 574 0.177954189222935 889 6151020 SGTC_2433 5607874 27.82 µM 0.923054275053311 0.168051579466508 no 575 0.177989460791209 882 2252428 SGTC_2235 salicylic acid 500 µM 0.921207332246291 0.168514664892412 no 576 0.178471095446653 877 338 A COX inhibitor and kinase inhibitor. SGTC_3057 9095946 49.47 µM 0.920757687109493 0.1686275288377 no 577 0.178588475355753 903 24540043 SGTC_2759 disulfiram 3.38 µM 0.919354746372 0.168979988601527 no 578 0.178955025588482 846 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.919280167297407 0.168998738284047 no 579 0.178974524314675 887 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_1812 st052057 4.327 µM 0.914609011071339 0.170175760929203 no 580 0.18019846320807 923 3645418 SGTC_2180 6301957 200 µM 0.912267823628088 0.170767657005291 no 581 0.180813874057025 926 845462 SGTC_2762 leflunomide 42.06 µM 0.911727127786143 0.17090454211267 no 582 0.180956189877115 918 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_1303 1160-0052 261 µM 0.90829378476961 0.171775381030557 no 583 0.181861512684191 935 3562476 SGTC_538 2922-0838 53.3 µM 0.90700618374077 0.172102699776289 no 584 0.182201763590821 975 777039 SGTC_3020 9089140 49.47 µM 0.906584501836959 0.172209981253285 no 585 0.18231328023066 916 17217859 SGTC_2399 5884133 200 µM 0.906094833413313 0.172334612941082 no 586 0.182442829872721 871 722445 SGTC_3134 9127454 49.47 µM 0.905677111274525 0.172440978142632 no 587 0.18255339041223 947 24262820 SGTC_2238 6671620 73.2395 µM 0.905129925029317 0.172580372314691 no 588 0.182698280136169 927 729941 SGTC_1793 st048256 72.231 µM 0.904384845226003 0.17277029481074 no 589 0.182895685604978 882 672022 SGTC_1838 st055369 84.5 µM 0.904006856716661 0.172866695836569 no 590 0.182995882799937 906 676036 SGTC_2283 7944793 200 µM 0.903764710248889 0.172928470136032 no 591 0.183060088981582 916 2970533 SGTC_2641 levomentholum 100 µM 0.903048869109535 0.173111171540163 no 592 0.183249979525019 879 16666 SGTC_1448 4255-0083 152 µM 0.902360541224392 0.173286966747568 no 593 0.183432687456022 956 5399660 SGTC_371 0195-0006 7.36 µM 0.899718752619829 0.17396272004488 no 594 0.184134970597323 811 3928593 SGTC_102 gallobenzophenone 83.616 µM 0.899167274298657 0.174103995925026 no 595 0.184281784398646 913 70837 SGTC_22 0964-0034 14.468 µM 0.898147413034283 0.174365452669696 no 596 0.184553482310115 934 138402 SGTC_1346 1488-2224 62.4 µM 0.898107934664572 0.174375578554722 no 597 0.184564004619717 927 3722427 SGTC_2899 9053889 58.44 µM 0.894097826176644 0.175406085077633 no 598 0.185634776148897 920 6470052 SGTC_2109 5483026 200 µM 0.891831093225137 0.175990288184104 no 599 0.18624173652195 917 759335 SGTC_346 4513-0042 7.16 µM 0.890694470186744 0.176283692280794 no 600 0.186546551109147 918 2827372 SGTC_3109 9122853 49.47 µM 0.885547754986758 0.177616119178255 no 601 0.187930637621644 1001 1234709 SGTC_2396 5342950 42.78 µM 0.885422331926883 0.177648668929036 no 602 0.187964446116141 920 1886677 SGTC_1736 st036774 51 µM 0.884853683180272 0.177796291676797 no 603 0.188117775699498 974 1272247 SGTC_993 3909-8757 62.7 µM 0.884199117385544 0.177966314496215 no 604 0.188294367365119 848 4288324 YLR208W SEC13 SGTC_1973 st070275 50.2 µM 0.884048872840904 0.17800535483131 no 605 0.188334915432182 911 17118334 SGTC_1682 st012968 530 nM 0.882201282126289 0.178485883983193 no 606 0.1888339843695 830 24207270 SGTC_2960 9079389 5.97 µM 0.882073719144517 0.178519091227557 no 607 0.188868471574957 938 16457355 SGTC_2507 purpurin 79.67 µM 0.882033980395788 0.178529436828784 no 608 0.188879215910829 960 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_2486 5283202 22.39 µM 0.881413302703516 0.178691073307534 no 609 0.189047080075097 863 1377751 SGTC_3135 9127742 49.47 µM 0.881324637470653 0.178714170968763 no 610 0.189071067354987 873 3643468 SGTC_1620 st003704 16.5 µM 0.874322545413452 0.180544178330914 no 611 0.190971312381111 954 2834414 SGTC_296 1222-0039 74.9 µM 0.874277594044239 0.180555964279015 no 612 0.190983549114752 897 5984176 SGTC_869 0564-0080 44.1 µM 0.870693591926209 0.181497218284864 no 613 0.191960739156841 900 6843321 SGTC_2448 5185112 27.17 µM 0.869915899960848 0.181701865643632 no 614 0.192173182811708 859 5718189 SGTC_3241 9133421 49.47 µM 0.868491398554769 0.182077093260286 no 615 0.192562689522804 971 17018221 SGTC_2007 4011539 71.82 µM 0.86578862937669 0.182790359514925 no 616 0.193303042920972 925 45595301 SGTC_2462 5162487 171.77 µM 0.865153503462177 0.182958223286782 no 617 0.193477270897049 972 2259986 SGTC_1472 k841-0093 193 µM 0.863763580215814 0.183325915461055 no 618 0.193858889224881 1006 X1472 SGTC_782 0083-0095 30.5 µM 0.863266713090809 0.183457469080468 no 619 0.19399542066193 1003 3591729 An indicator and reagent. SGTC_3301 9125354 19.7965 µM 0.862715802888411 0.18360340025634 no 620 0.194146870782216 881 41905162 SGTC_24 0417-1663 219 µM 0.862310888366244 0.183710704593997 no 621 0.194258231296837 965 4329390 SGTC_2195 6536160 144.242 µM 0.862307347110901 0.183711643216374 no 622 0.194259205392503 893 3834386 SGTC_638 3970-0837 4.09 µM 0.861739356636153 0.18386222978999 no 623 0.194415481440597 940 4118451 YLR208W SEC13 SGTC_382 3229-0966 23.2 µM 0.85826753838536 0.184784354238477 no 624 0.195372374939111 993 5722370 SGTC_1909 st060837 51.5 µM 0.856991935153084 0.18512387885392 no 625 0.195724670870028 902 678937 SGTC_160 3453-0671 289.699 µM 0.856612433366525 0.185224964786682 no 626 0.19582955600285 1017 5322268 SGTC_561 1550-0330 72.9 µM 0.856037602522929 0.185378144781874 no 627 0.195988490318447 924 6812934 SGTC_136 0097-0015 404.482 µM 0.855888370171811 0.185417924832924 no 628 0.196029764189779 1061 4861337 SGTC_3255 9139072 49.47 µM 0.85548158884375 0.185526385210833 no 629 0.196142296326032 996 17646060 SGTC_166 k072-0058 166.424 µM 0.85496411036566 0.185664417735783 no 630 0.196285508367377 1021 5846229 SGTC_2767 sibutramine 71.45 µM 0.852434554779409 0.186340069520682 no 631 0.196986474118001 970 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_2903 5923464 63.88 µM 0.851187195606503 0.186673802913141 no 632 0.197332687224176 982 2876576 SGTC_603 3794-0023 45.9 µM 0.850544447022211 0.18684591593156 no 633 0.197511230101713 974 3802260 SGTC_484 loperamide 105 µM 0.84988585151871 0.187022374216598 no 634 0.197694276214643 914 3955 An opioid-receptor agonist. SGTC_1093 fluphenazine 7.97 µM 0.849808050168126 0.187043226432575 no 635 0.197715906627727 992 6602611 An atypical antipsychotic. SGTC_611 3453-1652 23.7 µM 0.848536593560406 0.187384204343819 no 636 0.19806960096614 1010 1560575 SGTC_2521 angolensin 13.4 µM 0.848407262206365 0.187418909809145 no 637 0.198105599813042 946 821428 A flavenoid. SGTC_2566 crystal violet carbinol 226 nM 0.84836325284398 0.187430720422124 no 638 0.19811785053765 851 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_1770 st043884 66.3 µM 0.847717392574796 0.187604100216815 no 639 0.198297688897436 1011 670149 SGTC_1138 3761-0006 1.03 µM 0.847554027690937 0.18764797086466 no 640 0.198343193094652 984 12061087 SGTC_1863 st057641 20.1 µM 0.847012217362426 0.187793516102125 no 641 0.198494155843692 1024 3921635 SGTC_1648 st011736 69.8 µM 0.844625278453853 0.188435543696365 no 642 0.199160045352907 965 2855514 SGTC_864 0469-0573 172 µM 0.84438675713308 0.18849977435223 no 643 0.199226660032041 928 689425 SGTC_957 1187-1561 14.1 µM 0.842788741719468 0.188930447042804 no 644 0.199673302784006 981 1538454 SGTC_2194 5927483 104.545 µM 0.842302177168934 0.189061698782134 no 645 0.199809416354534 1028 760979 SGTC_3355 9151058 44.0485 µM 0.842286653493355 0.189065887248258 no 646 0.199813759929965 1008 17015728 SGTC_2882 9058044 58.44 µM 0.841603784139041 0.189250189798088 no 647 0.200004885212889 986 18076804 SGTC_335 4077-0256 27.6 µM 0.840854331566825 0.189452590045141 no 648 0.200214772641419 1059 3121989 SGTC_1754 st042065 16.137 µM 0.840182682959094 0.189634091373375 no 649 0.200402983153097 1020 1126236 YIL048W NEO1 SGTC_1191 1487-1166 10.6 µM 0.839181163344894 0.18990493318144 no 650 0.200683827988086 1066 3955771 SGTC_3142 9086498 49.47 µM 0.839038373477695 0.18994356732888 no 651 0.200723888173324 933 25236367 SGTC_2982 9019404 25.97 µM 0.838053871167143 0.190210072105441 no 652 0.201000224279321 919 22333232 SGTC_3333 9141820 12.094 µM 0.83519458198534 0.19098538329115 no 653 0.201804079879616 941 1939433 SGTC_3092 9117248 49.47 µM 0.833509356273147 0.191443247591072 no 654 0.202278761646134 1052 17141857 SGTC_2617 dihydrotanshinone i 20.83 µM 0.833435499493296 0.191463329345488 no 655 0.202299580335973 1021 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_2553 4-methylesculetin 85.09 µM 0.832230094737626 0.191791262872344 no 656 0.20263953997459 1034 5319502 SGTC_117 lucigenin 22.078 µM 0.831978037971701 0.191859879026439 no 657 0.202710670544512 1041 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_1766 st045414 44.774 µM 0.831086044470636 0.192102822631634 no 658 0.202962511443658 1062 253960 SGTC_718 1130-0073 349 µM 0.830120710057081 0.192365953360114 no 659 0.203235269470463 1014 6740020 SGTC_2432 5630864 12.22 µM 0.82986840861902 0.192434761966232 no 660 0.20330659401684 952 5714970 SGTC_3213 9129884 49.47 µM 0.829835475819169 0.192443744634656 no 661 0.203315905081682 951 17190742 SGTC_431 k089-0097 107 µM 0.828081466199375 0.192922534296431 no 662 0.203812182464902 1023 5499420 SGTC_1892 st058411 7.36 µM 0.823891360416855 0.194069243290204 no 663 0.205000644943465 1032 3934738 SGTC_2979 9012552 45.46 µM 0.821942591075349 0.194603976036571 no 664 0.205554785621862 975 17100905 SGTC_2848 9016370 25.97 µM 0.821584341222881 0.194702375508856 no 665 0.205656752141729 1042 7894410 SGTC_1454 4239-0054 42.6 µM 0.820777286856204 0.194924157723194 no 666 0.205886569184958 1056 1340767 SGTC_2070 5230947 200 µM 0.820446954453313 0.195014978860334 no 667 0.205980678663321 1096 2835538 SGTC_1891 st059073 26.2 µM 0.820238185316252 0.195072390825318 no 668 0.206040168740842 1085 688754 SGTC_1690 st023502 41.2 µM 0.819160393614197 0.195368949285341 no 669 0.206347454305981 997 24207482 SGTC_1919 st067113 52.3 µM 0.818805559017942 0.195466643260666 no 670 0.20644867939711 978 1268243 SGTC_608 k048-0125 159 µM 0.816234661247888 0.196175355337672 no 671 0.207182968081282 1037 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_3298 9116858 71.43 µM 0.815282110425223 0.19643833744109 no 672 0.207455423239843 1025 2506942 SGTC_1479 0549-0158 134 µM 0.814941546030949 0.196532412953807 no 673 0.20755288518965 1073 5440202 SGTC_1905 st060207 84.5 µM 0.814342797344723 0.196697873954497 no 674 0.207724299326651 988 1948547 SGTC_2779 methotrexate 400 µM 0.813287375649905 0.196989739470008 no 675 0.20802665668705 1117 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_1900 st060200 72.8 µM 0.812362530577156 0.197245710803504 no 676 0.208291819887469 1006 688945 SGTC_1086 cerivastatin 2.18 µM 0.811449225093108 0.19749868566619 no 677 0.208553870141868 1013 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_617 3770-0098 35 µM 0.811071848434942 0.19760327180462 no 678 0.208662205698637 981 5962639 SGTC_3089 9117425 49.47 µM 0.80803980431236 0.198444786742475 no 679 0.209533834211465 991 9401657 SGTC_2490 carminic acid 95.39 µM 0.806247799192672 0.1989431556868 no 680 0.210049991381559 986 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_491 tetrandrine 80.3 µM 0.803704956870838 0.199651630789652 no 681 0.210783695358486 1011 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1603 st002045 67.8 µM 0.802098312966369 0.200100048169229 no 682 0.211248045397311 1055 5887985 SGTC_1422 4031-0024 15.5 µM 0.801239718639715 0.200339931493698 no 683 0.21149644068978 1030 782427 SGTC_2175 5807670 165.306 µM 0.799976767140673 0.200693102291832 no 684 0.211862129009036 1035 241186 SGTC_3248 9135562 49.47 µM 0.799470696790375 0.20083472424049 no 685 0.212008765713708 1047 17650701 SGTC_639 0833-0042 114 µM 0.797658777660885 0.201342274775847 no 686 0.212534265851511 1040 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_217 ketoconazole 989 nM 0.797516747097738 0.20138209251431 no 687 0.212575490263917 1017 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_2895 9054447 58.44 µM 0.797394432735648 0.201416386671468 no 688 0.212610995785669 1043 2697450 SGTC_69 0096-0274 206.684 µM 0.797055387769181 0.201511465442246 no 689 0.212709432163517 1189 6741392 SGTC_738 1315-0003 72.4 µM 0.796858671239352 0.20156664321174 no 690 0.212766557913068 1056 6251474 SGTC_138 0850-0259 40.9225 µM 0.796731540907302 0.20160230729805 no 691 0.212803480853244 1078 6813004 SGTC_1523 st012844 44.7 µM 0.796542222552236 0.201655424101008 no 692 0.21285847222644 1018 4274103 SGTC_3220 9131269 49.47 µM 0.795746355701198 0.201878811097782 no 693 0.213089738672478 1064 17722206 SGTC_1480 1070-0044 41.2 µM 0.79573689610201 0.201881467145419 no 694 0.213092488365046 1073 3124987 SGTC_646 4092-0839 27.3 µM 0.792189445969428 0.202878987586376 no 695 0.214125110766445 1088 877796 SGTC_2516 gossypol 71.55 µM 0.791441596828695 0.203089653158019 no 696 0.214343172198664 1070 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1873 rapamycin 2 nM 0.791225792664282 0.203150468445499 no 697 0.214406121414787 1054 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_2580 diallyl disulphide 81.36 µM 0.790587989258957 0.203330269926748 no 698 0.214592228958587 998 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_1353 1498-1206 8.11 µM 0.789891604537855 0.20352669431682 no 699 0.214795537403458 1079 6756808 SGTC_1360 1598-0022 39.8 µM 0.788580090373344 0.203896931136375 no 700 0.21517873563373 1089 761525 SGTC_306 1672-3436 11.6 µM 0.788488582152268 0.203922778624793 no 701 0.215205487308591 1085 6797378 SGTC_1614 st002383 48.6 µM 0.788326779646059 0.203968486273901 no 702 0.215252793662793 1089 1947235 SGTC_1763 st044482 94.5 µM 0.788297211846435 0.203976839552072 no 703 0.215261439080919 1056 88505 SGTC_2176 5809774 33.9695 µM 0.78800656995725 0.2040589604186 no 704 0.215346431464867 1076 2870539 SGTC_3115 9123671 49.47 µM 0.787183864629809 0.204291522570079 no 705 0.215587120654757 1161 3286988 SGTC_1677 st019204 53.9 µM 0.786943835431366 0.204359403694846 no 706 0.215657372550253 976 3945625 SGTC_861 0443-0273 110 µM 0.786838523958934 0.20438919039738 no 707 0.215688199366404 1062 6149169 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.783853524030372 0.205234553639932 no 708 0.216563031602422 962 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.781026478599715 0.206037095774358 no 709 0.217393460729424 1013 279621 SGTC_1851 st056236 18.9 µM 0.779903218768107 0.206356482891831 no 710 0.21772392186414 1109 5393171 SGTC_2323 6148992 148.28 µM 0.779761885828241 0.206396690196554 no 711 0.217765522291665 980 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_1938 st074717 56.4 µM 0.779049718121794 0.206599362868702 no 712 0.217975213955198 990 17250979 SGTC_1889 st059080 5.18 µM 0.778286396610432 0.206816723997665 no 713 0.218200096626635 1103 176925 Isolated from Daphnopsis sellowiana. SGTC_3063 1327-0034 4 µM 0.776078506838294 0.207446197625158 no 714 0.218851316667072 1024 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_892 0929-0076 29 µM 0.775169626817483 0.207705649769941 no 715 0.219119716612486 1110 5751038 SGTC_127 0180-0333 59.125 µM 0.773641224694749 0.208142384883889 no 716 0.219571493140509 1090 771601 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.772327013598413 0.208518348705814 no 717 0.219960384899916 1076 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2005 4024620 188 µM 0.769560147257467 0.209311189558108 no 718 0.220780426449533 1079 236743 SGTC_1928 4'-methoxychalcone 40.3 µM 0.767883329899564 0.209792540955181 no 719 0.221278251001202 1128 641818 SGTC_1357 1503-1303 39.5 µM 0.767599632109068 0.209874044271944 no 720 0.221362540520262 1126 292895 SGTC_2411 st077133 39.94 µM 0.765935447324679 0.210352521282023 no 721 0.22185735645915 1106 1403142 YNL221C POP1 SGTC_1236 0330-0013 258 µM 0.7655470959415 0.210464269975245 no 722 0.22197291672466 1053 4617066 SGTC_3210 9128157 49.47 µM 0.765296078109361 0.210536519270134 no 723 0.222047629443538 985 17590849 SGTC_1008 4106-0037 6 µM 0.76509236008656 0.210595165179358 no 724 0.222108274441983 1075 2905394 SGTC_3182 9108849 49.47 µM 0.763452571458992 0.211067573030702 no 725 0.222596768763023 1135 17133045 SGTC_3262 9137218 49.47 µM 0.761231376254415 0.211708468225893 no 726 0.223259440300325 969 17650664 SGTC_694 1315-0438 43.2 µM 0.76075871578179 0.211844994695921 no 727 0.223400598613179 1006 6793154 SGTC_1119 parthenolide 318.541 nM 0.760250467754612 0.211991857976434 no 728 0.223552441662346 1147 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_1953 st076800 12.1 µM 0.758795003713753 0.21241275795295 no 729 0.22398759744742 1017 297591 SGTC_2036 5160441 105 µM 0.758245140978889 0.212571897605239 no 730 0.224152121008019 1116 134534 YIL048W NEO1 SGTC_1689 st020265 53.493 µM 0.756151665120234 0.213178422132428 no 731 0.224779134295093 1095 5758320 YPR016C TIF6 SGTC_2988 9073640 71.4286 µM 0.755150255261086 0.213468908401374 no 732 0.225079416107156 1094 9102229 SGTC_845 0330-0138 4.51 µM 0.754683765248037 0.21360430529142 no 733 0.225219374926041 1095 9039800 SGTC_2156 5649887 115 µM 0.75348996424527 0.213951029114586 no 734 0.225577769864035 1161 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_2076 5212012 200 µM 0.753078102945238 0.214070724794648 no 735 0.225701490945421 1005 604802 SGTC_600 1495-0418 41.6 µM 0.752266171525246 0.21430680349682 no 736 0.225945503495875 1112 5377768 SGTC_2397 5161689 200 µM 0.751831524950654 0.214433244357196 no 737 0.22607619060117 1113 2259942 SGTC_1419 3993-2473 62.6 µM 0.7515104296993 0.214526680424169 no 738 0.226172763161678 1134 704026 SGTC_2760 etidronate 98.04 µM 0.750718370728974 0.214757264222754 no 739 0.226411082344818 1120 3305 A chelator and antioxidant. SGTC_588 3970-1144 52.9 µM 0.75026269290939 0.214889986144232 no 740 0.226548253501872 1057 1888707 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.749884086119418 0.215000296383713 no 741 0.226662259902467 1091 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_1340 1486-1359 257 µM 0.748931984136634 0.215277844498003 no 742 0.226949100715228 1100 4309068 SGTC_3307 9126885 69.2785 µM 0.748564374497722 0.215385062331278 no 743 0.22705990563301 1110 24824909 SGTC_1164 k060-0068 93.7 µM 0.746679157861853 0.215935395356685 no 744 0.227628626797008 1159 5963676 SGTC_2276 7947513 42.08 µM 0.746532783753961 0.215978158990009 no 745 0.227672817611731 1054 2105100 SGTC_2318 6029776 164 µM 0.743014541950515 0.21700749917373 no 746 0.22873643817075 1110 818325 SGTC_414 piperonyl butoxide 100 µM 0.742519573813067 0.21715254029895 no 747 0.228886298452165 1133 5794 A potent inhibitor of cytochrome P450. SGTC_1322 1348-1070 12 µM 0.741275897424233 0.217517223375578 no 748 0.229263086346501 1102 6758089 SGTC_3129 9127257 49.47 µM 0.740707319543 0.217684065079126 no 749 0.229435460164141 1051 837894 SGTC_3227 9130768 49.47 µM 0.740608095031769 0.217713188772597 no 750 0.229465549163036 1127 17720899 SGTC_2514 salinomycin 42.74 µM 0.735420623416805 0.219238907649975 no 751 0.231041682784084 1171 23682228 A polyether potassium ionophore. SGTC_687 k029-0044 34.9 µM 0.734627547283991 0.219472704531607 no 752 0.231283178196045 1160 5829338 SGTC_300 r073-0011 5.04 µM 0.732912652337207 0.219978740726573 no 753 0.231805852870292 1181 2735780 SGTC_1443 4112-3303 14 µM 0.731126933098278 0.220506386756539 no 754 0.232350812361964 1153 704433 SGTC_676 falcarinol 140 µM 0.729632579686767 0.220948496593163 no 755 0.232807401077975 1178 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_1184 1269-1718 139 µM 0.729589792212094 0.220961162889275 no 756 0.232820481814287 1158 5403821 SGTC_984 1492-0255 2.91 µM 0.729538661362701 0.220976299604092 no 757 0.232836113773836 1079 1585198 SGTC_451 chloral hydrate 100 µM 0.72649863877887 0.22187733029448 no 758 0.233766570837437 1209 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_2083 5306046 65.942 µM 0.726369532899012 0.221915642308693 no 759 0.233806131729959 1157 539837 SGTC_2604 4'-hydroxychalcone 11.32 µM 0.724965453892927 0.222332544939958 no 760 0.23423661205815 1153 5282362 SGTC_1850 st056238 17 µM 0.723361305412512 0.222809399080329 no 761 0.234728968765418 1179 5393177 SGTC_765 1319-0117 244 µM 0.721194429384841 0.223454455682334 no 762 0.235394949341487 1144 3487746 YGL099W LSG1 SGTC_2992 9074591 71.4286 µM 0.720748825372426 0.223587238975402 no 763 0.23553203309961 1146 17741321 SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.720373651594904 0.22369906990492 no 764 0.235647484139164 1144 75037 A free radical scavenger. SGTC_2962 9082311 13.18 µM 0.719738913277191 0.223888343627693 no 765 0.235842881210147 1157 16459453 SGTC_1501 4491-0275 38.4 µM 0.71775825698446 0.224479543692145 no 766 0.236453177861841 1151 5104718 SGTC_2106 5357045 167.29 µM 0.716857874986366 0.224748588584943 no 767 0.23673089834045 1162 668842 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.713079758809403 0.225879526196222 no 768 0.237898201960656 1133 688803 SGTC_183 3914-0051 30.55 µM 0.71201938833512 0.226197513846127 no 769 0.238226385041647 1163 1596232 SGTC_1129 3453-1384 223 µM 0.711416662815405 0.226378373997326 no 770 0.238413038192683 1215 1084452 SGTC_1843 st055809 45.5 µM 0.710442502532158 0.226670863372037 no 771 0.238714887183961 1149 16413835 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.70909001549575 0.22707729786153 no 772 0.239134309272265 1188 688761 SGTC_201 4262-0159 12.803 µM 0.708890482460042 0.22713729408894 no 773 0.239196220880523 1132 1341029 SGTC_1324 1418-0026 34.4 µM 0.708849395259939 0.22714964942822 no 774 0.239208970606911 1174 1372513 SGTC_1377 2944-0135 198 µM 0.708837607224932 0.227153194280268 no 775 0.239212628608363 1208 1894137 SGTC_2063 5246145 200 µM 0.70754606843812 0.227541769625567 no 776 0.239613597255285 1212 711240 SGTC_2350 9023895 38.85 µM 0.707425568046325 0.22757804273339 no 777 0.239651026276781 1174 2997209 SGTC_1292 0kpi-0043 232 µM 0.70741674795044 0.227580697892378 no 778 0.239653766040987 1159 3333905 SGTC_189 3970-0742 2.116 µM 0.707271397629297 0.227624455961912 no 779 0.239698918307768 1193 2891807 SGTC_134 0269-0018 6.916 µM 0.707077539397339 0.227682824828002 no 780 0.239759146510731 1097 4378915 SGTC_1651 st011928 86.1 µM 0.706316893636743 0.227911929387497 no 781 0.239995544962027 1174 720198 SGTC_3043 9092303 49.47 µM 0.70398241081909 0.228615878914584 no 782 0.240721863728554 1149 25236084 SGTC_925 2064-1272 59.6 µM 0.702228808309353 0.229145469558113 no 783 0.241268241257002 1159 6815817 SGTC_697 0508-1955 564 µM 0.701342884619961 0.229413281261138 no 784 0.241544528367538 1183 6243113 SGTC_2972 9093619 59.92 µM 0.701131378290853 0.229477244832528 no 785 0.24161051483163 1188 25236256 SGTC_2231 micatex 6.853 µM 0.701129159897916 0.229477915770065 no 786 0.241611206985267 1178 20737 An antifungal of unknown mechanism. SGTC_3181 9108277 49.47 µM 0.69875417943848 0.230196842377507 no 787 0.242352834166165 1167 17097298 SGTC_1460 k062-0059 9.15 µM 0.698473735611987 0.230281818176349 no 788 0.242440488773676 1174 1373085 SGTC_370 0180-0345 38.7 µM 0.697969186877208 0.230434742978654 no 789 0.242598232115307 1133 3989527 SGTC_1291 0993-0025 5.79 µM 0.69533939550563 0.23123273073521 no 790 0.243421315499902 1204 4353356 SGTC_1558 st069300 45.6 µM 0.693767779238101 0.231710359291108 no 791 0.243913926053251 1135 24208000 SGTC_251 melphalan 456.522 µM 0.693734425556228 0.231720501733619 no 792 0.243924386323952 1259 460612 A DNA alkylator. SGTC_104 0074-0074 590.992 µM 0.693217108807065 0.231877843032762 no 793 0.244086656466937 1068 3943124 SGTC_1605 st000082 49.1 µM 0.693179349211871 0.23188932990027 no 794 0.244098503046662 1202 1114022 SGTC_1379 2144-0755 36.5 µM 0.693165751170306 0.231893466645692 no 795 0.244102769330507 1232 5392327 SGTC_367 0335-0881 7.1 µM 0.692264473879089 0.232167741479813 no 796 0.244385627981182 1167 23828853 SGTC_888 0916-0002 6.97 µM 0.69153086262304 0.232391125758918 no 797 0.244615996326171 1235 2802138 YIL048W NEO1 SGTC_1853 st056710 91.2 µM 0.691258275153905 0.232474158967895 no 798 0.244701623937252 1259 269167 SGTC_1047 2043-3044 82 µM 0.690759816116621 0.23262603785761 no 799 0.244858246072869 1204 669592 SGTC_683 panaxydol 45 µM 0.687018144052926 0.233767872802465 no 800 0.246035647387566 1196 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_10 0279-0212 42.575 µM 0.68506871867318 0.234364001794813 no 801 0.246650279267388 1234 39851 YBR002C RER2 SGTC_2050 5263056 171 µM 0.684249297033555 0.234614829618829 no 802 0.246908878952142 1226 763468 YGL055W OLE1 SGTC_2400 5203494 178.7 µM 0.684004135398457 0.234689903295212 no 803 0.246986277228545 1193 6777674 SGTC_1559 coumarin 343 70.1 µM 0.683877364336512 0.234728728484349 no 804 0.247026304331144 1237 108770 A hepatotoxic, DNA x-linker. SGTC_2155 5570423 76 µM 0.682833606629629 0.235048527001402 no 805 0.247355995624781 1177 797402 SGTC_1678 st019265 80.2 µM 0.681539439259042 0.235445382930673 no 806 0.247765110102588 1237 5367020 SGTC_992 3909-8734 162 µM 0.681443192651446 0.235474911681272 no 807 0.247795550177273 1220 4288319 SGTC_2878 9043973 25.97 µM 0.68069438647024 0.23570471746888 no 808 0.248032444533196 1247 6465167 SGTC_3045 9092950 49.47 µM 0.680218340199357 0.235850878555614 no 809 0.248183110626819 1244 44120432 SGTC_1710 st031758 61.5 µM 0.678474704705752 0.236386655577871 no 810 0.248735378456034 1237 5394341 SGTC_60 0986-0278 202 µM 0.677859551105708 0.236575837170352 no 811 0.248930374276414 1061 3110598 SGTC_844 0330-0132 15.3 µM 0.677332923157138 0.236737860142844 no 812 0.249097373213816 1222 2828079 SGTC_1255 0566-0045 221 µM 0.675901084883828 0.237178689569416 no 813 0.249551724446371 1246 2788469 SGTC_401 neomycin 50 µM 0.675816031645784 0.237204889648465 no 814 0.249578727405614 1190 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_2892 9047358 58.44 µM 0.675543541300772 0.237288839175071 no 815 0.249665248916217 1205 6466771 SGTC_1631 benzylvanillin 81.9 µM 0.675513560834563 0.237298076630535 no 816 0.249674769327962 1233 75506 SGTC_657 3534-0529 86.7 µM 0.674768329034336 0.237527757782494 no 817 0.249911482489119 1254 1049549 SGTC_1840 st055363 71 µM 0.674342841165776 0.237658948249206 no 818 0.250046686560995 1180 676033 SGTC_1857 st056007 79.3 µM 0.674239404993116 0.237690846679782 no 819 0.250079560556676 1244 619834 SGTC_2720 fluspirilene 36.88 µM 0.671773272202437 0.238452066573077 no 820 0.250864023310271 1208 3396 An atypical antipsychotic. SGTC_1886 st057356 49.9 µM 0.669488556645938 0.239158477933468 no 821 0.251591939012662 1200 24207747 SGTC_1864 st057645 30.4 µM 0.668903166096212 0.239339658760975 no 822 0.251778625213947 1267 688666 SGTC_490 phenamil 164 µM 0.668287785339515 0.23953020249028 no 823 0.251974954385219 1175 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_2268 7933382 153.85 µM 0.666830753575117 0.23998168125629 no 824 0.252440123178411 1277 935025 YOR257W CDC31 SGTC_142 0335-0849 62.6745 µM 0.666549201261236 0.240068977084781 no 825 0.252530063105618 1271 3889043 YPR107C YTH1 SGTC_2732 terfenadine 20 µM 0.663999352512745 0.240860350311681 no 826 0.253345362748887 1241 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_121 0557-0495 61.343 µM 0.663699862234901 0.240953393415354 no 827 0.253441213784106 1353 3104427 SGTC_2413 inermin 26.06 µM 0.662787231527008 0.241237042306373 no 828 0.253733416198718 1337 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_890 0929-0006 47.2 µM 0.662671257053451 0.241273100579304 no 829 0.253770561101384 1236 1378169 SGTC_855 0428-0020 25 µM 0.662655052069608 0.241278139194775 no 830 0.25377575154453 1237 6812414 SGTC_3066 9117245 49.47 µM 0.662186662078586 0.241423800399453 no 831 0.253925800562739 1294 17176980 SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.662005759164331 0.241480070868808 no 832 0.253983765382577 1254 5377381 SGTC_790 1575-0012 79.1 µM 0.661767249389051 0.241554271034799 no 833 0.254060199173593 1268 378741 YLR208W SEC13 SGTC_50 0929-0078 56.389 µM 0.660601413831076 0.241917139473438 no 834 0.254433981046895 1177 1377751 SGTC_1247 0448-0043 5.84 µM 0.660549912895049 0.241933176050871 no 835 0.25445049955319 1287 3089013 YGL099W LSG1 SGTC_1645 Cervolide 78 µM 0.659478811243297 0.242266830854752 no 836 0.254794174036395 1198 23173 A fragrance. SGTC_3285 9112818 20.8695 µM 0.657740119094681 0.242808974811698 no 837 0.25535256906726 1290 17017947 YPR165W RHO1 SGTC_2488 5268135 45.7 µM 0.656727515326424 0.243125018454407 no 838 0.255678069430691 1266 1270356 YLR208W SEC13 SGTC_2251 lansoprazole 556 µM 0.6561370068455 0.243309424617828 no 839 0.255867987696497 1180 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_1385 3091-4834 14.1 µM 0.653945806191939 0.243994361029993 no 840 0.256573360630018 1238 4072814 SGTC_1588 farnesol 29.9 µM 0.653890736983521 0.244011588226402 no 841 0.256591101085338 1283 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_1172 0370-0043 85 µM 0.653709064183804 0.244068425237483 no 842 0.256649631210185 1296 376585 SGTC_162 k030-0015 37.8 µM 0.652462480332985 0.24445861615469 no 843 0.257051434679352 1312 1809920 YMR134W ERG29 SGTC_630 4356-0227 183 µM 0.649433055799125 0.245408249918844 no 844 0.258029251845333 1289 779312 SGTC_800 3448-7362 155 µM 0.64937570461591 0.245426246895782 no 845 0.258047781861579 1334 15991913 SGTC_2985 9022375 71.43 µM 0.64808581387674 0.245831205850137 no 846 0.25846472440348 1303 4939335 SGTC_2351 9026858 72.31 µM 0.648016314252464 0.245853035314871 no 847 0.258487199271821 1213 1409300 SGTC_953 1188-0045 9.7 µM 0.647242470246849 0.246096165899759 no 848 0.258737514202452 1266 6144426 SGTC_1044 1222-0021 1.78 µM 0.646426920152624 0.246352539449256 no 849 0.25900145550432 1264 4306703 SGTC_258 haloperidol 50.781 µM 0.645877278663692 0.246525403594209 no 850 0.259179417748965 1233 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_44 0929-0055 61.211 µM 0.645808774644942 0.246546952898032 no 851 0.259201602324919 1225 1379590 SGTC_1137 ixabepilone 100 µM 0.645495778491626 0.246645424910751 no 852 0.259302976556662 1279 154225 A novel microtubule stabilizer. SGTC_2533 agelasine 13.65 µM 0.644548898711882 0.246943451851476 no 853 0.259609779809814 1310 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_802 4112-3352 742 µM 0.642550422807102 0.247573096881806 no 854 0.260257930624379 1354 704594 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.642314615782047 0.247647447385637 no 855 0.260334463123413 1233 4620898 SGTC_2328 6201408 200 µM 0.639983426548844 0.248383118061606 no 856 0.26109168712499 1258 2890418 SGTC_245 methotrexate 289.6 µM 0.639939352313015 0.24839703810618 no 857 0.261106014349897 1288 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_881 0833-0569 170 µM 0.63909778926137 0.248662910216181 no 858 0.261379659005313 1259 5418700 SGTC_2808 7946468 45.46 µM 0.638376492653269 0.248890907532244 no 859 0.261614314702947 1297 2970879 SGTC_2771 fluoxetine 41.05 µM 0.637763190625183 0.249084855934878 no 860 0.261813922098602 1307 3386 A selective serotonin reuptake inhibitor. SGTC_468 gf-109203x 121 µM 0.63694511954795 0.24934368485346 no 861 0.262080295879839 1216 2396 A protein kinase C inhibitor. SGTC_2242 6630449 61.2675 µM 0.635541458784595 0.249788120981545 no 862 0.262537668120476 1304 691249 YDR170C SEC7 SGTC_700 3453-2283 142 µM 0.634855260252331 0.250005542557556 no 863 0.262761409307464 1352 565664 SGTC_518 1021-0119 62.6 µM 0.634035311854897 0.250265474323737 no 864 0.263028888679072 1235 1097762 SGTC_2119 5528445 120.635 µM 0.633346878703943 0.250483825068759 no 865 0.263253573241223 1328 791935 SGTC_1529 apigenin 74 µM 0.632583524593778 0.250726056517027 no 866 0.263502824386833 1385 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_264 promethazine 12.5 mM 0.629332271186266 0.251759148714072 no 867 0.264565774165228 1326 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_2472 5377652 49.4 µM 0.626487257264577 0.252664998092533 no 868 0.265497696208325 1290 1610903 SGTC_164 4100-3994 89.624 µM 0.624543022780164 0.253285026225953 no 869 0.266135512547979 1343 4615967 SGTC_2167 5876490 200 µM 0.623331277603368 0.253671863352934 no 870 0.266533424016681 1427 686534 SGTC_2084 5306078 60.6385 µM 0.623201375032171 0.253713351813203 no 871 0.266576099121579 1283 679340 SGTC_423 5-fluorouracil 457 µM 0.62310611543646 0.253743778217111 no 872 0.266607395642002 1264 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_246 cycloheximide 667 µM 0.621917465554337 0.25412360014113 no 873 0.266998069994639 1215 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_3319 9138450 16.7555 µM 0.620533455829074 0.254566222932629 no 874 0.267453317411443 1290 2029690 SGTC_1428 4049-0204 61.7 µM 0.620493218178512 0.254579097451108 no 875 0.267466558783893 1366 X1428 SGTC_2635 hydroquinidine 100 µM 0.619946648294277 0.25475401281231 no 876 0.267646456285249 1336 442912 An experimental heart treatment. SGTC_3281 9140613 49.47 µM 0.619026104867152 0.255048750768721 no 877 0.267949580883693 1218 16013766 SGTC_1757 st041620 31.8375 µM 0.619023465970557 0.25504959594228 no 878 0.267950450091106 1293 5289815 SGTC_809 3998-0021 90 µM 0.616496603118533 0.255859559745534 no 879 0.268783406578694 1266 715485 SGTC_1573 oleylamine 1.06 µM 0.615930381590989 0.256041241046955 no 880 0.268970234375049 1322 5356789 An amine of the fatty acid oleic acid. SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.61380804781497 0.256722824416567 no 881 0.269671089274218 1347 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2768 sulfasalazine 50.2 µM 0.611390162014196 0.257500473248562 no 882 0.270470657036264 1408 5384001 An antioxidant and salicylic acid derivative. SGTC_2708 st078559 56 µM 0.611351147849899 0.257513031143293 no 883 0.27048356828847 1261 17250902 SGTC_1003 4049-0218 100 µM 0.611153264931738 0.257576730674053 no 884 0.270549059919847 1361 295161 SGTC_2071 5230951 39.92 µM 0.60830448267644 0.258494674437729 no 885 0.271492774253502 1341 1799272 SGTC_1169 aniline yellow 25.8 µM 0.607933919508478 0.258614202906405 no 886 0.271615650891115 1315 6051 A DNA damaging agent. SGTC_2589 lobaric acid 100 µM 0.607596285613937 0.258723134653623 no 887 0.271727632472971 1309 73157 A novel microtubule depolymerizer. SGTC_513 4245-1575 41.7 µM 0.605817373441781 0.25929746191706 no 888 0.272318015846902 1303 719745 SGTC_1591 genipin 88.4 µM 0.605397275579028 0.25943318790042 no 889 0.272457530416459 1364 442424 A DNA cross-linking agent. SGTC_780 0109-0199 192 µM 0.60454361278784 0.259709103838891 no 890 0.272741141276119 1408 610414 SGTC_2549 cedrol 20.94 µM 0.603886883594112 0.259921471070035 no 891 0.272959424883749 1355 6708665 A sedative which affects the nervous system. SGTC_2682 pyrogallin 40.03 µM 0.602976121566504 0.260216133348359 no 892 0.273262287199185 1331 822798 An ATP competetive kinase inhibitor. SGTC_3070 9117005 49.47 µM 0.601591606955089 0.260664400128256 no 893 0.273723008536311 1396 8779016 SGTC_1388 3346-4487 254 µM 0.601437139539505 0.260714436953761 no 894 0.273774434072766 1395 3345614 SGTC_199 4063-0024 41.6 µM 0.601287157305974 0.260763025617706 no 895 0.27382437096702 1374 306215 SGTC_907 3448-6986 75.5 µM 0.6006562758681 0.260967458739712 no 896 0.274034473550334 1409 590582 SGTC_1901 st060216 58.6 µM 0.599266937004957 0.261417955588315 no 897 0.27449744608209 1328 688792 SGTC_867 0518-0118 155 µM 0.594684525542362 0.262906640484637 no 898 0.276027183764934 1367 6848158 SGTC_727 3032-0951 202 µM 0.593929204754539 0.263152436479367 no 899 0.276279732355979 1354 3652836 SGTC_717 1532-0246 73.2 µM 0.593535519525579 0.263280595796408 no 900 0.276411409636221 1327 9561992 SGTC_2227 7312221 64.1025 µM 0.592423441748131 0.263642790968602 no 901 0.276783536384443 1359 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_983 1491-0821 12.2 µM 0.591994374175945 0.263782602901223 no 902 0.276927177822943 1357 46495113 SGTC_1647 st011722 22.4 µM 0.591248371827265 0.264025778209513 no 903 0.277177008219982 1355 2854783 SGTC_395 anisomycin 6.25 µM 0.589526918423742 0.264587358122034 no 904 0.277753930070125 1309 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2515 chrysin 20.77 µM 0.589466295970012 0.264607145709498 no 905 0.277774257550625 1396 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_1381 2324-0066 62.1 µM 0.588191819391318 0.265023317858466 no 906 0.278201773860664 1368 10885928 SGTC_2702 st077768 96.8 µM 0.588187177640945 0.265024834199833 no 907 0.27820333149708 1303 6484119 SGTC_996 3970-0799 1.8 µM 0.587814993746529 0.265146431522239 no 908 0.278328239425915 1444 6615648 YGL040C HEM2 SGTC_986 1493-0483 84 µM 0.586296308043515 0.265642899427239 no 909 0.278838205807926 1316 40079 SGTC_1628 st004252 77.7 µM 0.585708141920182 0.265835301190579 no 910 0.279035830864966 1422 692968 SGTC_533 1222-0222 6.71 µM 0.585435926293386 0.26592437266679 no 911 0.279127318942079 1458 3982874 SGTC_2352 9027995 87.8 µM 0.585230094255282 0.265991732855816 no 912 0.279196506052964 1368 2997347 SGTC_1187 1391-0724 117 µM 0.583727308970445 0.266483793202449 no 913 0.279701895467669 1375 6997986 SGTC_3211 9128781 49.47 µM 0.583566775876279 0.266536384119103 no 914 0.27975590927183 1359 17194361 SGTC_1819 st053448 58.6 µM 0.581099447940896 0.267345344726093 no 915 0.280586715350859 1373 2857616 SGTC_2787 5284540 71.43 µM 0.579347404498258 0.267920536780053 no 916 0.281177392646375 1396 736958 SGTC_593 1203-0218 61.7 µM 0.577183631803524 0.268631757753907 no 917 0.281907706535812 1427 3666956 SGTC_1014 4130-3005 69.3 µM 0.576713846112986 0.268786299160449 no 918 0.282066388686648 1354 743608 SGTC_1234 0326-0494 15.5 µM 0.576479905654352 0.268863273217385 no 919 0.282145424107669 1441 1547813 SGTC_2319 6033012 152.6 µM 0.574538280467164 0.269502558253121 no 920 0.282801801968421 1325 847246 SGTC_2045 5106652 78.05 µM 0.570373523763951 0.270876379626457 no 921 0.284212191543065 1390 673349 SGTC_610 4215-0184 155 µM 0.569772711401593 0.271074856684302 no 922 0.284415933128682 1426 5605015 SGTC_1878 temozolomide 1 mM 0.569236913017241 0.271251917679022 no 923 0.284597686658018 1411 5394 DNA alkylating agent. SGTC_1554 st069299 38.7 µM 0.568529146536329 0.271485895931984 no 924 0.284837860189993 1385 24207999 SGTC_1525 8-methoxypsoralen 92.5 µM 0.568262334530963 0.271574126543345 no 925 0.284928425288851 1473 4114 Related to psoralen; DNA damaging agent. SGTC_1167 k781-0610 148 µM 0.566585152818832 0.272129071424049 no 926 0.285498032287121 1415 4525169 SGTC_927 2425-1185 123 µM 0.566221391565872 0.272249506879559 no 927 0.285621644936823 1353 730375 SGTC_1641 st009299 47.1 µM 0.565399469543307 0.272521729439966 no 928 0.285901042647616 1355 4046054 SGTC_1911 st060208 74.3 µM 0.564972293404532 0.272663264563019 no 929 0.286046304842844 1458 688783 SGTC_686 1319-0111 510 µM 0.564605678218446 0.272784763270697 no 930 0.286171001110595 1470 4562600 SGTC_1725 st036284 20.55 µM 0.563499087371895 0.273151657635522 no 931 0.286547540682162 1518 707914 SGTC_1494 4358-1428 177 µM 0.563080132099254 0.273290627621761 no 932 0.286690159867139 1485 1564571 SGTC_560 2332-1943 155 µM 0.560758626116318 0.274061319215507 no 933 0.287481047581354 1396 21177716 SGTC_2561 acetosyringone 100 µM 0.558924765416107 0.27467088101631 no 934 0.288106533429183 1370 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_960 1222-0186 7.7 µM 0.55784842186049 0.275028960807393 no 935 0.288473947187168 1458 3126296 SGTC_266 formosanin C 406 nM 0.557556696416194 0.275126052114939 no 936 0.288573566743378 1407 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_2100 5377183 190 µM 0.554977034339525 0.275985342394396 no 937 0.289455184477347 1458 2844202 SGTC_76 0433-0009 400.328 µM 0.554005686880008 0.276309241297993 no 938 0.289787476891284 1411 2841569 SGTC_98 0074-0023 107.663 µM 0.551804607698384 0.277043887541606 no 939 0.290541115030893 1351 3563821 SGTC_1181 1222-0449 220 µM 0.551391493365375 0.277181877700965 no 940 0.290682665403968 1452 658318 SGTC_447 ml7 120 µM 0.548185173589485 0.278254007700298 no 941 0.291782380732717 1489 4216 Selective myosin light chain kinase inhibitor. SGTC_3013 9080133 71.4286 µM 0.547292717119077 0.27855278681925 no 942 0.292088823254606 1477 17050193 SGTC_339 3091-4833 71.4 µM 0.546192937654776 0.27892118891941 no 943 0.292466660117759 1416 3240077 SGTC_2215 7188065 200 µM 0.543377198415844 0.279865478987447 no 944 0.293435060831885 1449 940217 SGTC_2721 ifenprodil 61.44 µM 0.543194073216927 0.279926945758095 no 945 0.293498093421668 1468 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_1032 k061-1018 98.7 µM 0.542615556746907 0.280121170326822 no 946 0.293697262808811 1564 4005393 SGTC_1007 4101-0031 70 µM 0.541550311541939 0.280478974434638 no 947 0.294064164804514 1485 1146276 SGTC_261 5-fluorouridine 15.376 µM 0.541452406834666 0.280511870642495 no 948 0.294097896713257 1473 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_515 4092-1064 102 µM 0.541228786162909 0.280587014707721 no 949 0.29417494927672 1533 717353 SGTC_2698 st077697 67.5 µM 0.541188974712775 0.280600393714999 no 950 0.294188668012906 1367 3154499 SGTC_2342 7990637 118.86 µM 0.540533240616845 0.280820803643941 no 951 0.294414671730898 1460 2033102 YER133W GLC7 SGTC_1602 st001878 87.6 µM 0.540301080202951 0.280898859085495 no 952 0.294494706782481 1454 595405 YLR310C CDC25 SGTC_1489 4065-0444 182 µM 0.539973267118813 0.281009092091973 no 953 0.294607734260895 1460 2877968 SGTC_1941 st076221 61.8 µM 0.538281042676886 0.281578465016172 no 954 0.2951915185332 1415 2828568 SGTC_2090 5301565 104.445 µM 0.53713510571956 0.281964347470798 no 955 0.295587146513524 1447 2056344 SGTC_2476 5806916 10.51 µM 0.53666422515449 0.282122985454247 no 956 0.295749785887367 1433 2870194 SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.535824972923999 0.282405833033969 no 957 0.296039760566103 1531 165506 SGTC_222 nsc-310342 10.666 µM 0.535543262715829 0.282500806512727 no 958 0.296137125063331 1455 432556 SGTC_302 1094-0063 18.9 µM 0.535169583117124 0.282626809492893 no 959 0.29626629862704 1385 5440289 SGTC_1991 st073000 8.92 µM 0.534366446701305 0.282897714647303 no 960 0.296544014239951 1479 4301969 YIL048W NEO1 SGTC_2412 st077135 33.4 µM 0.533951116500537 0.283037858167901 no 961 0.296687677563044 1510 13258915 SGTC_2065 5221596 34.26 µM 0.533417178698759 0.283218072007633 no 962 0.296872414237485 1467 788581 SGTC_186 3455-3465 67.277 µM 0.531396162517024 0.283900700205403 no 963 0.297572140102941 1401 755278 SGTC_3059 1327-0034 3 µM 0.531137876191327 0.283987996961857 no 964 0.297661619455496 1388 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1486 3970-0793 4.53 µM 0.530197508981804 0.284305934894911 no 965 0.297987498990242 1476 2844330 SGTC_2523 spermine 47.74 µM 0.529866821124857 0.284417780801474 no 966 0.298102135841363 1462 1103 A DNA binding polyamine. SGTC_39 0986-0283 58.349 µM 0.529046920757686 0.284695179781865 no 967 0.298386450616338 1544 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_715 0868-0130 184 µM 0.528383231252121 0.28491982208444 no 968 0.298616686891694 1580 2876258 SGTC_1924 st058459 75.1 µM 0.526764100648528 0.285468211764077 no 969 0.299178707782348 1421 688683 SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.524262282804369 0.286316549051402 no 970 0.300048063258395 1452 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_2166 5933061 31.504 µM 0.523852712837375 0.286455543382334 no 971 0.300190493319431 1603 2877375 SGTC_3175 9106517 49.47 µM 0.523225855934656 0.286668339607518 no 972 0.300408545207476 1408 41468073 SGTC_1481 3346-2004 36 µM 0.52160564760352 0.287218691242867 no 973 0.300972465151298 1444 2770522 SGTC_2232 chlorophetanol 41.5365 µM 0.520908005122772 0.287455820053232 no 974 0.301215429295765 1529 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_1989 st071868 50.2 µM 0.520683146234145 0.287532269357161 no 975 0.301293758498515 1536 16414057 SGTC_2665 lovastatin 100 µM 0.520088397929903 0.287734522916494 no 976 0.30150098223831 1430 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_2496 diffractaic acid 79.83 µM 0.519594795260057 0.287902431330961 no 977 0.301673013239167 1574 94870 An apoptosis inducer which activates caspases. SGTC_1795 st049545 62.3 µM 0.519044882547233 0.288089549155718 no 978 0.301864721448258 1461 5291882 SGTC_2492 derrusnin 100 µM 0.513370540080716 0.290023690838505 no 979 0.303846074505994 1398 1715307 Part of coumarin class of compounds. SGTC_3019 9081971 49.47 µM 0.511015775572717 0.290828113122988 no 980 0.304670005174126 1562 16451803 SGTC_1950 st077106 7.18 µM 0.51048781262351 0.291008616100216 no 981 0.304854875357988 1432 13831864 SGTC_2160 5660466 132.927 µM 0.509115710200041 0.291477962881072 no 982 0.305335560251768 1488 2859134 SGTC_252 miconazole 1.30953 nM 0.504859521755522 0.292936093151834 no 983 0.306828753151632 1456 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_1276 0871-0068 94.2 µM 0.503848728169199 0.29328287833767 no 984 0.307183841250217 1539 3414906 SGTC_433 pimozide 108 µM 0.502789066475211 0.293646633466447 no 985 0.307556290749119 1414 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_758 0868-0029 16 µM 0.501162604872592 0.294205362621516 no 986 0.308128344898022 1568 762687 SGTC_1061 3448-9325 110 µM 0.501065036994798 0.294238895172415 no 987 0.308162676018796 1465 723482 SGTC_3171 9103192 49.47 µM 0.499643077073261 0.294727800755446 no 988 0.308663210123568 1517 13018434 SGTC_2663 amphotericin b 100 µM 0.497875743542755 0.295335976073579 no 989 0.309285812518141 1481 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_585 0kpi-0023 191 µM 0.497591600577109 0.295433809292316 no 990 0.309385962569184 1545 64601 SGTC_936 3005-4620 401 µM 0.497589158302334 0.295434650256164 no 991 0.30938682344352 1580 777207 SGTC_2938 9059746 27.26 µM 0.496800763561257 0.295706180711245 no 992 0.309664778362221 1520 6471769 SGTC_851 0394-0702 453 µM 0.496425299361658 0.295835534362063 no 993 0.309797189576102 1560 762646 SGTC_280 3448-3607 3.04 µM 0.496320004733903 0.29587181477551 no 994 0.30983432721426 1489 626179 SGTC_2252 omeprazole 400 µM 0.495314500349328 0.296218375169471 no 995 0.310189068457301 1539 4594 A proton pump inhibitor. SGTC_295 k015-0027 31 µM 0.495222945722743 0.296249939930177 no 996 0.31022137764758 1482 3887424 SGTC_304 1310-0298 97 µM 0.494569923260011 0.296475123448269 no 997 0.310451868630245 1435 1550234 SGTC_1994 st072947 40.9 µM 0.494526012404596 0.296490268162631 no 998 0.310467370089825 1514 5286565 YDL195W SEC31 SGTC_1488 4013-0813 75.9 µM 0.493050047625805 0.29699952981315 no 999 0.310988612509873 1473 2910057 SGTC_1946 st076057 65.1 µM 0.492625484819149 0.297146093523661 no 1000 0.311138618747654 1429 953009 SGTC_1220 1838-0075 193 µM 0.491991380508933 0.297365054796675 no 1001 0.311362718466391 1506 5529645 SGTC_442 cape 100 µM 0.490226152375346 0.297974989983328 no 1002 0.31198693834334 1603 5281787 SGTC_402 epigallocatechin gallate 10 µM 0.490179693536577 0.297991050497275 no 1003 0.312003374420518 1471 65064 An antioxidant. SGTC_649 1123-0311 367 µM 0.489644765639526 0.29817599995846 no 1004 0.312192646665327 1479 693629 YIL048W NEO1 SGTC_1686 st019653 115.5 µM 0.488723901615091 0.298494507907007 no 1005 0.312518589877397 1578 97252 SGTC_1462 k081-0014 26.5 µM 0.48638975756802 0.299302532955775 no 1006 0.313345425565061 1366 3270634 SGTC_470 aa-861 153 µM 0.485778337292921 0.299514355967461 no 1007 0.313562167449946 1466 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_1434 4073-0095 163 µM 0.485554031083593 0.299592082587387 no 1008 0.313641697725063 1508 24133745 SGTC_1178 0988-0033 191 µM 0.484511153897458 0.299953580515818 no 1009 0.314011575207305 1528 5392207 SGTC_3289 9119912 71.43 µM 0.484432101732764 0.299980990824679 no 1010 0.314039620282233 1512 17014829 SGTC_174 3553-0389 74.3 µM 0.483980075004935 0.300137746972427 no 1011 0.314200004933856 1525 738071 SGTC_2287 7945887 168.79 µM 0.483964225449254 0.300143244034829 no 1012 0.314205629188395 1537 1245853 SGTC_1084 voriconazole 435 nM 0.483231050484164 0.300397579054174 no 1013 0.314465845299566 1525 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_3108 9121785 49.47 µM 0.482615644466474 0.300611135705235 no 1014 0.314684334418915 1594 17140271 SGTC_693 4161-2696 114 µM 0.48242427150066 0.300677559439606 no 1015 0.31475229126826 1596 805759 SGTC_1555 citronellol 128 µM 0.480273334485613 0.301424584380682 no 1016 0.315516523591345 1588 8842 A terpine precursor. SGTC_1540 guanosine 70.6 µM 0.477715821106658 0.302313899620702 no 1017 0.316426241065264 1508 6802 Guanosine is a purine nucleoside SGTC_1524 corynanthine 62.1 µM 0.47713722507951 0.302515255967862 no 1018 0.316632204353353 1566 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_294 k038-0071 157 µM 0.476723632032179 0.302659226710021 no 1019 0.316779466256765 1519 24152826 SGTC_488 nitrendipine 139 µM 0.476130586894824 0.302865717842303 no 1020 0.316990673653408 1556 4507 Dihydropyridine L-type calcium channel blocker. SGTC_2162 5663267 200 µM 0.47591908729063 0.302939374697229 no 1021 0.317066011662002 1604 6456493 SGTC_49 0717-0965 32.132 µM 0.475675475750674 0.303024224789971 no 1022 0.317152797620976 1588 5889349 YGL099W LSG1 SGTC_982 1491-0518 27.5 µM 0.475118447132882 0.303218278243022 no 1023 0.317351275358114 1518 3091256 SGTC_763 3453-1109 128 µM 0.474257837163298 0.303518200275106 no 1024 0.3176580269986 1534 1560353 SGTC_2278 7948257 134.34 µM 0.473898987468883 0.303643298296699 no 1025 0.317785970646274 1608 1247028 SGTC_2335 9018011 154.17 µM 0.473126938950892 0.303912518900414 no 1026 0.318061309237065 1625 6458208 SGTC_2021 4019055 173 µM 0.472366560140069 0.304177774165864 no 1027 0.318332584340523 1516 44827708 YER133W GLC7 SGTC_1739 st037196 92.5 µM 0.471626676073686 0.30443597888153 no 1028 0.318596641225198 1635 612214 SGTC_412 gemfibrozil 100 µM 0.469893301521241 0.305041273496207 no 1029 0.319215625136986 1518 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_3073 9114972 49.47 µM 0.469787608024839 0.305078198960114 no 1030 0.319253384361435 1615 41905075 SGTC_1376 2910-0861 41.3 µM 0.463697921761885 0.307209055301502 no 1031 0.321432093182859 1561 1112859 SGTC_2105 5350118 200 µM 0.46361742423886 0.307237266232932 no 1032 0.321460934202353 1511 2133313 SGTC_1929 genistein trimethyl ether 50.5 µM 0.463335652528228 0.307336024124361 no 1033 0.321561897132347 1692 136420 SGTC_2491 paeonol 100 µM 0.463289153511227 0.307352322862618 no 1034 0.321578559678375 1502 11092 Increases levels of cortical cytochrome oxidase. SGTC_1059 3448-6867 171 µM 0.46323817050272 0.307370193757475 no 1035 0.32159682943898 1565 3934407 SGTC_722 3534-0461 190 µM 0.462549568617876 0.307611611747359 no 1036 0.321843632173568 1509 658262 SGTC_598 3937-0236 20.2 µM 0.461572920243459 0.307954159312515 no 1037 0.322193808851999 1575 1379313 SGTC_291 SEC14.278 35.5 µM 0.461287187946831 0.308054408113863 no 1038 0.322296287858544 1621 1068044 SGTC_1031 k035-0009 16 µM 0.461121128678263 0.308112676371994 no 1039 0.322355851872098 1659 5180959 SGTC_2051 5263410 176 µM 0.460986414783323 0.308159949458084 no 1040 0.322404175924149 1547 227584 SGTC_587 k089-0003 57 µM 0.460749645591476 0.308243042959909 no 1041 0.322489116133271 1540 9659696 SGTC_2428 5615643 7.78 µM 0.460502128801548 0.308329918808599 no 1042 0.32257792191688 1569 2253075 SGTC_3074 9116018 49.47 µM 0.460038356468915 0.308492727029966 no 1043 0.3227443446075 1575 17027303 SGTC_321 4534-3890 65.3 µM 0.458764216706779 0.308940210193165 no 1044 0.323201746846158 1605 699746 SGTC_67 0335-0847 266 µM 0.458138663682768 0.309160010892985 no 1045 0.323426411460971 1767 4552207 YOR254C SEC63 SGTC_3196 9111891 49.47 µM 0.456940252502602 0.30958128767673 no 1046 0.323856995356255 1516 18891510 SGTC_968 1309-0633 340 µM 0.456224193661486 0.309833122926822 no 1047 0.32411438476071 1582 3761976 SGTC_7 0192-1582 4.227 µM 0.455787308977587 0.309986817514064 no 1048 0.324271465528393 1563 252616 SGTC_1417 3966-0327 90.4 µM 0.454854188758485 0.310315197312595 no 1049 0.324607071239017 1591 651118 SGTC_2103 5378138 10 µM 0.453986490541685 0.310620689826251 no 1050 0.324919275138102 1597 244142 SGTC_2880 9042983 58.44 µM 0.453203177624666 0.310896584822876 no 1051 0.32520122226624 1555 6464714 SGTC_1643 st009866 20.2 µM 0.452193273895384 0.311252445546479 no 1052 0.325564876634559 1605 3156273 YOR207C RET1 SGTC_3025 9087895 49.47 µM 0.451557250160752 0.311476652420859 no 1053 0.325793986513324 1624 17173641 SGTC_779 1360-0071 233 µM 0.451386043129363 0.311537017138713 no 1054 0.325855670334319 1710 7566 SGTC_1719 st032227 49.2 µM 0.449732922433931 0.312120140094236 no 1055 0.326451514736865 1512 3125804 SGTC_2320 7373003 200 µM 0.449511707052586 0.312198207529507 no 1056 0.326531282396562 1477 5415828 SGTC_1978 st071761 42 µM 0.449495486789218 0.312203932030994 no 1057 0.326537131544569 1497 5147680 SGTC_2674 ligustilide 100 µM 0.44838628046614 0.312595503783195 no 1058 0.326937220728334 1560 5319022 A signalling regulator. SGTC_2186 6124449 200 µM 0.448245150432989 0.312645340660039 no 1059 0.326988140417132 1593 3834182 YLR033W RSC58 SGTC_1306 1185-0270 9.02 µM 0.44787262261492 0.312776906881006 no 1060 0.327122563853912 1640 1548076 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.447812914532725 0.312797996294492 no 1061 0.327144111084244 1563 6857784 SGTC_1301 naphtanilide LB 4.81 µM 0.445279263731869 0.313693467731871 no 1062 0.328058975700249 1657 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_2513 baicalein 25.65 µM 0.444711307339307 0.313894352231235 no 1063 0.328264198393087 1479 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_2449 5812982 45.77 µM 0.443840727161797 0.314202380959671 no 1064 0.328578870356994 1549 776185 SGTC_1386 3228-0095 33.8 µM 0.442399489237973 0.314712604323665 no 1065 0.329100074281349 1652 870181 SGTC_948 3448-0295 75.3 µM 0.441757868187358 0.314939863293199 no 1066 0.329332214722774 1550 678569 SGTC_2859 9028643 45.46 µM 0.440748131811506 0.315297648784596 no 1067 0.329697673646592 1597 17151580 SGTC_487 nimodipine 119 µM 0.4405740517776 0.315359349050828 no 1068 0.3297606957508 1621 4497 L-type voltage-gated calcium channels inhibitor SGTC_458 nppb 133 µM 0.435162429651377 0.317279984979618 no 1069 0.331722265546405 1697 4549 A chloride channel blocker. SGTC_2233 sulbentine 40.3845 µM 0.434675102341337 0.317453184832274 no 1070 0.33189913648111 1556 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_2493 resveratrol 26.09 µM 0.432269829634295 0.318308622089156 no 1071 0.332772656152453 1530 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_1971 st069429 63.5 µM 0.432241400247833 0.318318738832028 no 1072 0.332782986256477 1649 1246522 YGL099W LSG1 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.43136536388836 0.318630547249811 no 1073 0.333101365084457 1586 165521 SGTC_197 4544-0043 41.561 µM 0.431288524430874 0.318657902919354 no 1074 0.333129296673659 1565 896523 SGTC_1199 1638-0010 4.46 µM 0.430896480870757 0.318797490006793 no 1075 0.333271821192225 1551 3111136 SGTC_1088 bifonazole 369 nM 0.430869291417002 0.318807171763875 no 1076 0.333281706608866 1559 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_3028 9087778 49.47 µM 0.42955624882577 0.319274873638285 no 1077 0.333759234326839 1509 17217395 SGTC_607 4491-0986 66.8 µM 0.429398783719593 0.319330981579042 no 1078 0.333816519388349 1687 698981 YDR232W HEM1 SGTC_1927 st060202 13.8 µM 0.429347685284803 0.31934918985418 no 1079 0.333835109589943 1682 688887 SGTC_3010 9080089 71.4286 µM 0.428637404203478 0.319602334554513 no 1080 0.334093560281856 1671 17027233 SGTC_1212 0520-0165 585 µM 0.425037199622459 0.320886741224503 no 1081 0.335404778517413 1783 5403258 SGTC_2373 9071805 200 µM 0.422522167753686 0.321785277092247 no 1082 0.3363219618643 1735 10149009 SGTC_759 3486-0358 89.3 µM 0.421700098488626 0.322079201138443 no 1083 0.336621966280397 1753 875103 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 0.421184822291274 0.322263490636499 no 1084 0.336810063253916 1699 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2149 5554786 194.827 µM 0.420016234220795 0.322681600223357 no 1085 0.33723679711359 1614 745063 YPR165W RHO1 SGTC_2885 9057732 51.95 µM 0.419599879866853 0.322830622032368 no 1086 0.337388888074439 1600 6471414 SGTC_1561 5-methoxyflavone 52.9 µM 0.418881784933147 0.323087709864388 no 1087 0.337651264914514 1623 94525 SGTC_1103 duloxetine 36.1 µM 0.418645041270712 0.323172485876195 no 1088 0.337737783394233 1702 60835 A selective serotonin reuptake inhibitor. SGTC_2250 alverine citrate 130 µM 0.417757685954723 0.323490322416769 no 1089 0.338062145574979 1570 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_3138 9097216 49.47 µM 0.416443323384044 0.323961342849661 no 1090 0.33854281611229 1590 25237486 SGTC_1827 berberine 7.24 µM 0.416194712945115 0.324050467657111 no 1091 0.338633764108349 1476 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_532 1548-0774 215 µM 0.415898622397133 0.324156626853885 no 1092 0.338742093809127 1714 5932993 SGTC_1875 nocodazole 6 µM 0.415735436517117 0.324215141020929 no 1093 0.338801803807551 1662 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_224 benfluorex 43.875 µM 0.415424091754022 0.324326793112918 no 1094 0.338915736636439 1688 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_2334 9017922 200 µM 0.41519095211013 0.324410410223612 no 1095 0.339001060903098 1754 3163164 SGTC_2123 5259487 200 µM 0.414324715984642 0.324721169209069 no 1096 0.339318157656815 1707 2173474 SGTC_1826 st055655 41.6 µM 0.414303980574738 0.324728609456673 no 1097 0.339325749513161 1607 676168 SGTC_2881 9058953 51.95 µM 0.414048464897669 0.324820298935046 no 1098 0.339419306829641 1524 17122249 SGTC_939 1165-0479 45.3 µM 0.413316642185463 0.325082965583199 no 1099 0.339687319192343 1637 1377347 SGTC_380 3970-0968 6 µM 0.413098627883466 0.325161232343417 no 1100 0.339767177336005 1568 2891601 SGTC_509 pifithrin 175 µM 0.410822710974917 0.32597874268222 no 1101 0.340601269394314 1657 4817 A p53 inhibitor. SGTC_2016 5121758 140 µM 0.408533829608747 0.326801754391736 no 1102 0.341440899658604 1568 2795203 SGTC_40 0327-0103 19.753 µM 0.406584710542052 0.327503263099291 no 1103 0.342156514323303 1562 409036 SGTC_3313 9133968 57.047 µM 0.406209028589962 0.327638545167407 no 1104 0.342294510387912 1613 1494643 SGTC_1135 dihydrocapsaicin 536.708 nM 0.40524626388184 0.327985337442062 no 1105 0.342648250686059 1526 107982 A Capsaicinoid. SGTC_2904 7225135 42.03 µM 0.405207131025822 0.327999436416331 no 1106 0.34266263185373 1657 4446116 SGTC_849 0386-0493 241 µM 0.404920570702824 0.328102687220711 no 1107 0.342767948571287 1596 726119 SGTC_2910 7948405 25.97 µM 0.404879115544498 0.328117625053419 no 1108 0.342783185192889 1728 2971328 SGTC_315 k915-0449 187 µM 0.40384881151715 0.328488970112975 no 1109 0.343161950030834 1679 20970215 YNL149C PGA2 SGTC_685 1278-0033 54.9 µM 0.402666214042011 0.328915414102354 no 1110 0.343596895930847 1696 3590572 SGTC_893 0958-0369 48.9 µM 0.402332561587297 0.329035769312855 no 1111 0.343719647000509 1752 6819948 SGTC_1482 3346-2049 8.48 µM 0.402238400902068 0.329069738190173 no 1112 0.343754291792203 1668 3826804 SGTC_2570 licareol 100 µM 0.401189953736728 0.329448065374688 no 1113 0.344140138340294 1588 443158 SGTC_651 3253-0966 34.4 µM 0.401097717329149 0.329481356808529 no 1114 0.344174090694905 1604 781462 SGTC_2340 7987427 183.45 µM 0.400519523876422 0.329690078385045 no 1115 0.344386953145638 1657 2239331 SGTC_463 ikarugamyin 104 µM 0.400484605902392 0.329702685094996 no 1116 0.344399809809001 1659 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_567 1080-0542 68.4 µM 0.400390350345062 0.329736715883941 no 1117 0.344434515239313 1698 5950415 SGTC_1854 st056233 32.9 µM 0.395321202998615 0.331568992027151 no 1118 0.34630292669946 1747 5393174 SGTC_1471 k673-0312 37 µM 0.394837250142541 0.331744131743543 no 1119 0.346481501070351 1647 24099884 SGTC_1091 telmisartan 47.6 µM 0.394384840712732 0.331907889343768 no 1120 0.346648467055344 1707 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_2816 7982706 58.44 µM 0.392564249616151 0.332567208921896 no 1121 0.347320674336396 1613 2981853 SGTC_3326 9140064 16.379 µM 0.391398244522072 0.332989745284017 no 1122 0.347751444853579 1573 1868434 SGTC_1597 7-benzyloxygramine 47.5 µM 0.391026724860715 0.33312442098982 no 1123 0.347888740917528 1604 260807 SGTC_386 1509-0011 3.07 µM 0.390321901013574 0.333379978446307 no 1124 0.348149265220198 1628 3107280 SGTC_428 3448-4153 16.5 µM 0.389165877596824 0.333799300850294 no 1125 0.34857672174023 1570 3834874 SGTC_411 enrofloxacin 100 µM 0.388521420016836 0.334033154031446 no 1126 0.348815102866143 1792 71188 A bacterial gyrase inhibitor. SGTC_1033 k072-0102 21.3 µM 0.387758655813364 0.334310020215817 no 1127 0.349097322058397 1749 5965931 SGTC_2313 7726885 200 µM 0.38689681880749 0.334622956077726 no 1128 0.349416298170699 1654 726423 SGTC_2715 st079500 56.4 µM 0.385260736902303 0.335217338820221 no 1129 0.350022124003861 1597 28246688 SGTC_1173 0443-0020 122 µM 0.382502576284976 0.336220302781625 no 1130 0.351044309162241 1633 5331295 SGTC_1787 fluconazole 80 µM 0.382375325854915 0.336266603715472 no 1131 0.351091494760559 1601 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_2201 6605497 169.863 µM 0.380933905620682 0.336791247523941 no 1132 0.351626146430311 1719 670741 SGTC_586 0957-0265 8.15 µM 0.378037584510983 0.337846401686234 no 1133 0.352701336872104 1710 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_955 1216-0110 33 µM 0.377283397041212 0.338121368186439 no 1134 0.352981504667817 1585 3619719 SGTC_1248 0469-0687 58.6 µM 0.376553244298827 0.338387654246998 no 1135 0.353252819933278 1726 4017482 SGTC_1783 st039459 87.517 µM 0.376062035692833 0.338566843087969 no 1136 0.353435388650565 1792 729761 SGTC_1917 st066507 28.5 µM 0.376038080271671 0.338575582762779 no 1137 0.353444293084034 1635 3156428 SGTC_1949 st076024 69.1 µM 0.375168437067379 0.338892914194099 no 1138 0.353767601124139 1588 2921930 SGTC_708 3448-5400 146 µM 0.374020867283936 0.339311835601543 no 1139 0.354194395608647 1663 3462195 SGTC_381 3461-2219 42.7 µM 0.370012261427161 0.340776737206425 no 1140 0.355686677235733 1778 2883159 SGTC_2724 maprotiline 69.64 µM 0.369705765278453 0.340888842128422 no 1141 0.355800867815904 1726 4011 A tricyclic antidepressant. SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.368673497851932 0.341266510569321 no 1142 0.356185552494901 1691 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_3081 9117243 49.47 µM 0.367201817855773 0.341805218750677 no 1143 0.356734241722056 1788 45595589 SGTC_1550 gossypolone 36.6 µM 0.366936015192724 0.341902550157983 no 1144 0.356833373081603 1685 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_516 3992-2719 87.3 µM 0.366334246004522 0.342122944338162 no 1145 0.357057839196008 1572 5350887 YDR037W KRS1 SGTC_1769 st044406 64.4 µM 0.365644160226224 0.342375750129312 no 1146 0.357315309221494 1681 670903 SGTC_93 0109-0045 59.227 µM 0.363798662251219 0.343052176052869 no 1147 0.358004180834207 1721 88733 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.363681389939534 0.343095176619389 no 1148 0.358047970889512 1650 688664 SGTC_891 0929-0073 133 µM 0.363476293043864 0.343170384955864 no 1149 0.35812455956357 1751 5603632 SGTC_2406 ethylparaben 405.7 µM 0.363460934906712 0.343176016982754 no 1150 0.35813029493315 1458 8434 A possible steroid mimic. SGTC_41 0478-0632 82.643 µM 0.362890343479418 0.343385284893781 no 1151 0.3583434002731 1831 3750424 SGTC_2833 9001315 45.46 µM 0.361634174425886 0.343846161776449 no 1152 0.358812711606586 1679 2989378 SGTC_732 3970-1727 52.7 µM 0.360111976492316 0.344404953265308 no 1153 0.359381698427961 1827 1275699 SGTC_3353 9151644 39.2805 µM 0.359450205134544 0.344647992371067 no 1154 0.359629161248215 1698 4909158 SGTC_2248 tofa 1.1 µM 0.35928613010726 0.344708259736976 no 1155 0.359690524584784 1711 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1621 st003705 32.4 µM 0.359161281017737 0.344754121432981 no 1156 0.359737220017297 1797 24207032 SGTC_1642 st009582 77.7 µM 0.35860969765904 0.344956765733 no 1157 0.359943545520598 1809 6739311 SGTC_2690 usnic acid 100 µM 0.357652501220746 0.345308532356785 no 1158 0.360301691664535 1817 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_283 0987-0079 11.7 µM 0.356874663063886 0.345594483853003 no 1159 0.360592819156859 1784 411556 SGTC_124 0136-0217 7.121 µM 0.356679426822054 0.345666271103336 no 1160 0.360665904428008 1801 3976905 SGTC_175 3793-3120 23.7 µM 0.355790913830089 0.345993042320974 no 1161 0.36099857707341 1682 5322297 SGTC_2786 7743617 45.45 µM 0.35572914767878 0.346015762520274 no 1162 0.361021707163424 1597 583674 SGTC_2861 9024595 19.48 µM 0.355367952048004 0.34614863662662 no 1163 0.361156977301446 1708 16482810 SGTC_3206 9114350 49.47 µM 0.354800613612069 0.346357383336558 no 1164 0.361369484326215 1678 17087243 SGTC_2360 9040895 200 µM 0.352616678736933 0.347161376322344 no 1165 0.362187915992723 1678 4914414 SGTC_2497 7-hydroxyflavone 100 µM 0.352465715358889 0.347216977402356 no 1166 0.362244512999275 1774 5281894 SGTC_180 1486-1293 102.781 µM 0.350527863969402 0.347930996023996 no 1167 0.362971291270942 1881 4140536 SGTC_2681 menadione 3.18 µM 0.350179493535352 0.348059413507225 no 1168 0.36310199772388 1712 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_3122 9126309 49.47 µM 0.349947043869284 0.348145109580492 no 1169 0.363189220285387 1800 17591206 SGTC_2983 9022671 12.99 µM 0.347071970008941 0.349205688803581 no 1170 0.364268625422552 1854 6405161 SGTC_2066 5222451 176 µM 0.346221757265114 0.3495195479798 no 1171 0.364588032380918 1679 2281147 SGTC_1837 st055472 66.5 µM 0.345192207870624 0.349899747679995 no 1172 0.364974938188999 1764 676091 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.344365945553821 0.350204984923468 no 1173 0.36528554798022 1842 6728940 SGTC_570 0987-0065 62.6 µM 0.34370850013446 0.35044792710585 no 1174 0.365532759022448 1809 3104428 SGTC_2429 5902844 64.44 µM 0.343638093163851 0.350473947834754 no 1175 0.365559236595421 1843 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_2358 9037157 4 µM 0.3410183195099 0.351442651253099 no 1176 0.366544895262578 1746 2388925 SGTC_3040 9091894 49.47 µM 0.340149012159435 0.35176430531823 no 1177 0.36687215676991 1789 25236966 SGTC_2377 9073351 62.6 µM 0.338148856027153 0.352504789612959 no 1178 0.367625507459163 1672 7337946 YHR072W ERG7 SGTC_1256 0570-0116 285 µM 0.338015946902005 0.352554014179924 no 1179 0.367675585231123 1670 410638 SGTC_2443 5493264 126.67 µM 0.337018520280899 0.35292350242651 no 1180 0.36805146941406 1816 5340055 SGTC_3160 9100216 49.47 µM 0.335874706221452 0.353347389432516 no 1181 0.368482675821892 1757 17191039 SGTC_539 4859-0462 2.54 µM 0.333399884843786 0.354265157802763 no 1182 0.369416225036536 1858 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_2089 5281248 129.67 µM 0.331966857019284 0.354796972703515 no 1183 0.369957142726296 1692 2737878 SGTC_823 0417-1665 178 µM 0.329790590361943 0.355605154160084 no 1184 0.370779098895393 1743 3429856 SGTC_2273 7815444 169.05 µM 0.32896013416238 0.355913724982511 no 1185 0.371092910419617 1867 2824616 SGTC_753 1322-0200 289 µM 0.328475919041946 0.356093687341128 no 1186 0.37127592447573 1755 5403907 SGTC_1564 D-Arginine 115 µM 0.327916710789609 0.356301561382213 no 1187 0.371487319173754 1646 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_2218 6965428 192.983 µM 0.326804658676709 0.356715070493985 no 1188 0.371907817815647 1810 675684 SGTC_2676 harmalol 100 µM 0.326136997511298 0.356963416775032 no 1189 0.372160353018653 1813 5459187 A monoamine oxidase inhibitor SGTC_1337 1486-1011 40.3 µM 0.326111084432239 0.356973056744482 no 1190 0.372170155453866 1724 X1337 SGTC_913 3487-1245 167 µM 0.325677171794487 0.357134490899923 no 1191 0.372334308826002 1642 4016153 SGTC_1539 benzyladenosine 56 µM 0.325644072264269 0.35714680639851 no 1192 0.372346831652964 1732 92208 A nucleotide analog. SGTC_2431 5490079 200 µM 0.325169274245971 0.357323483114479 no 1193 0.372526480877291 1697 5722345 SGTC_256 clotrimazole 625 nM 0.324488687283311 0.357576789135072 no 1194 0.37278404278832 1733 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_1617 st002906 78 µM 0.321342510519861 0.358748571042341 no 1195 0.373975422247492 1727 5150859 SGTC_2846 9008642 19.48 µM 0.321295620424471 0.358766045176295 no 1196 0.373993187509239 1708 2992898 SGTC_486 niguldipine 82 µM 0.321191678614185 0.358804781342611 no 1197 0.374032568922143 1777 1236 A calcium channel blocker. SGTC_2695 st077686 51.995 µM 0.314910495152133 0.361148282523966 no 1198 0.376414806379909 1703 2876092 SGTC_3146 9095609 49.47 µM 0.314879710459863 0.36115978117933 no 1199 0.376426493642322 1812 17173999 SGTC_2801 7907800 81.82 µM 0.313762205638521 0.361577274881529 no 1200 0.376850825668098 1724 6620925 SGTC_421 streptovitacin 30 mM 0.313609542547913 0.361634321788309 no 1201 0.37690880551734 1731 91467 include heat shock SGTC_626 0214-0009 33 µM 0.312469421221964 0.362060457729763 no 1202 0.377341899399026 1838 3437874 SGTC_2423 st077119 87.2 µM 0.312036756903444 0.362222216737042 no 1203 0.377506294493856 1755 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_153 4077-0274 519.67 µM 0.311016911370039 0.36260360086949 no 1204 0.377893882680153 1904 3121976 SGTC_86 0417-1630 471.922 µM 0.310586871832054 0.362764460489276 no 1205 0.378057354350486 1822 3634867 SGTC_1416 3966-0321 25.3 µM 0.309737780539987 0.36308214076665 no 1206 0.378380184978694 1776 582530 YLR208W SEC13 SGTC_1188 1403-0014 4.57 µM 0.308836839379756 0.363419323263758 no 1207 0.378722822146226 1766 9614867 SGTC_2835 9006588 71.43 µM 0.30861008438914 0.363504204327584 no 1208 0.378809074424901 1725 2345538 SGTC_1105 epirubicin 18.1 µM 0.30803311647153 0.363720210603271 no 1209 0.379028566694243 1717 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_3192 9110362 49.47 µM 0.307492419588515 0.363922676990152 no 1210 0.379234296014768 1793 16649480 SGTC_1679 SEC14.276 6.7 µM 0.307077945879739 0.364077904269509 no 1211 0.379392021945677 1916 1005053 YMR079W SEC14 SGTC_1954 st077032 68.9 µM 0.306728609179516 0.364208753980986 no 1212 0.37952497590071 1675 698907 SGTC_1218 1348-1416 30.7 µM 0.305201848749264 0.364780812389529 no 1213 0.38010621222112 1742 6787668 SGTC_1143 3454-2408 5.08 µM 0.304726131603552 0.364959119371425 no 1214 0.380287372722537 1785 X1143 SGTC_2723 salbutamol 83.58 µM 0.303662339410027 0.3653579526427 no 1215 0.38069257634065 1854 9884233 β2-adrenoceptor agonist SGTC_2994 9053520 71.4286 µM 0.302483450864441 0.365800107569745 no 1216 0.381141773629521 1878 4647384 SGTC_157 1348-1695 65.819 µM 0.300979410923703 0.366364472887573 no 1217 0.381715097349446 1761 5380510 SGTC_1490 4089-0339 670 nM 0.30060425518945 0.366505288776491 no 1218 0.381858143145218 1898 742542 SGTC_3139 9095020 49.47 µM 0.298812548228378 0.367178059235317 no 1219 0.382541538017221 1754 25236292 SGTC_2216 7189485 200 µM 0.29691084811972 0.367892577530157 no 1220 0.383267286921376 1865 731273 SGTC_1331 1472-0049 76.2 µM 0.296560795662765 0.368024151278224 no 1221 0.38340092275066 1731 24051409 SGTC_352 k048-0007 5.11 µM 0.29534830113029 0.368480009590144 no 1222 0.383863911140137 1816 6811911 SGTC_188 3229-0966 278.469 µM 0.29427618606022 0.368883244099162 no 1223 0.384273434100478 1910 5722370 SGTC_2689 tacrolimus 100 µM 0.293894899273198 0.369026685163733 no 1224 0.384419107936372 1786 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_2950 9072895 21.46 µM 0.293448000079325 0.369194833003794 no 1225 0.384589870325191 1734 17332245 SGTC_1633 st005664 67.9 µM 0.292664537049077 0.369489674896838 no 1226 0.384889289445022 1741 2063822 SGTC_1122 capsaicin 818.572 nM 0.292119493279685 0.369694837380856 no 1227 0.38509763145591 1857 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_15 0266-0086 27.098 µM 0.29205380115231 0.369719567369357 no 1228 0.385122744395965 1892 1712902 YIL048W NEO1 SGTC_2368 9071271 200 µM 0.29103574498976 0.370102886339427 no 1229 0.385511990816556 1728 27209959 SGTC_713 1488-1073 324 µM 0.290344643429872 0.370363173783093 no 1230 0.38577629425794 1917 3312542 SGTC_2452 5863136 48.41 µM 0.287160161019417 0.371563300875975 no 1231 0.386994844556021 1773 2184096 SGTC_3046 9092212 49.47 µM 0.28658631419862 0.371779698148803 no 1232 0.38721454737821 1790 25236637 SGTC_286 k060-0067 22.9 µM 0.286016339669067 0.371994675292437 no 1233 0.38743280342591 1793 5985051 SGTC_1921 5740136 50 µM 0.283957497941285 0.372771540095873 no 1234 0.38822147609616 1950 1774243 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.282625787936473 0.373274311539986 no 1235 0.388731855018409 1770 2374 Ca(2+)-ATPase inhibitor. SGTC_1966 st070145 16.1 µM 0.281383693736974 0.373743444162521 no 1236 0.38920806180015 1757 3748532 SGTC_2518 prenyletin 46.28 µM 0.281260884814232 0.373789838640687 no 1237 0.389255154595523 1921 3873459 A coumarin with calcium channel inhibitory activity. SGTC_2678 equilin 100 µM 0.28122586090152 0.373803070230701 no 1238 0.38926858530179 1923 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_1887 st057648 70.8 µM 0.280795312774203 0.373965737999807 no 1239 0.389433699458965 1940 688672 SGTC_2362 9071156 126 µM 0.279888135622897 0.374308557063691 no 1240 0.389781664995088 1876 653133 SGTC_2286 7945697 125 µM 0.278640655662489 0.374780137652894 no 1241 0.390260304574023 1739 1245733 SGTC_1916 st067606 49.2 µM 0.278493430075444 0.37483580520982 no 1242 0.390316803842089 1903 19590279 SGTC_355 1311-2252 105 µM 0.276492267263515 0.375592724306129 no 1243 0.391084999043079 1768 5338538 SGTC_2369 9071472 200 µM 0.27236526268512 0.377155230954853 no 1244 0.392670589866601 1853 17296037 SGTC_74 000s-0487 160.283 µM 0.271795822039882 0.377370982970254 no 1245 0.392889508932277 1966 677548 SGTC_489 paxilline 115 µM 0.271414116585016 0.377515626537683 no 1246 0.393036272965684 1803 105008 A toxic potassium channel blocker. SGTC_1229 0139-0193 12.2 µM 0.271168171472873 0.377608834147277 no 1247 0.393130845813295 1947 3090752 SGTC_366 0181-0206 4.31 µM 0.270705584860288 0.377784163270542 no 1248 0.393308740525787 1982 274874 SGTC_2824 7998404 51.95 µM 0.270438279760132 0.377885488469027 no 1249 0.393411546923124 1847 837851 SGTC_3120 9124077 49.47 µM 0.270227078054096 0.377965552946496 no 1250 0.393492781031759 1946 18774327 YGL155W CDC43 SGTC_885 0865-0106 16.8 µM 0.268807943668251 0.37850366854322 no 1251 0.394038740053916 1764 2793380 SGTC_2049 5262831 67.185 µM 0.268380562280605 0.378665771717517 no 1252 0.394203199961474 1813 763417 SGTC_101 0490-5701 117.494 µM 0.267303292156872 0.379074468430047 no 1253 0.394617826094492 1934 4661669 SGTC_192 3455-0609 60.9 µM 0.266679483822524 0.379311191828417 no 1254 0.394857975779341 1858 3769639 SGTC_994 3910-0338 138 µM 0.266621540967359 0.379333182338401 no 1255 0.394880284273008 1913 3479481 SGTC_3121 9125696 49.47 µM 0.266581907669531 0.379348224218167 no 1256 0.39489554362936 1991 1235365 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.266266464784851 0.379467949606028 no 1257 0.395016999157702 1792 6708514 SGTC_2837 9008476 45.46 µM 0.265906850166303 0.379604454340835 no 1258 0.395155474650293 1872 2992805 SGTC_3184 9108758 49.47 µM 0.262903601991826 0.380745030270602 no 1259 0.396312439981337 1842 902885 SGTC_2212 7123476 200 µM 0.26146371329573 0.381292240800329 no 1260 0.396867464530994 1914 1085715 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.260697566833923 0.381583501406161 no 1261 0.39716287128937 1941 23847180 SGTC_1475 4092-1048 11.7 µM 0.257391570226918 0.382841086416823 no 1262 0.39843825485709 1856 2881759 SGTC_1560 lithocholic acid 53.1 µM 0.256619952376662 0.383134784502566 no 1263 0.39873608545986 1968 9903 A bile acid which acts as a detergent. SGTC_1133 3473-0247 50 µM 0.256461062685647 0.383195270453334 no 1264 0.398797421349321 1741 711311 SGTC_2752 diclazuril 33.15 µM 0.256165426039803 0.383307820660161 no 1265 0.398911552059971 1969 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_1962 st076595 64.5 µM 0.255063822789045 0.383727292653752 no 1266 0.399336902715163 1839 279619 SGTC_3219 9131112 49.47 µM 0.253953737469405 0.38415013235015 no 1267 0.399765649378047 1930 17612988 YMR079W SEC14 SGTC_2731 amoxapine 43.43 µM 0.253312018092458 0.384394630944543 no 1268 0.400013554904772 1968 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_1279 0874-0590 65.2 µM 0.252307200768905 0.384777564217773 no 1269 0.400401811370135 1904 3523074 SGTC_2608 thymoquinone 42.66 µM 0.250654906869063 0.385407493422606 no 1270 0.401040463458693 1954 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_485 niflumic acid 177 µM 0.250628279281639 0.385417647544498 no 1271 0.401050757844323 1917 4488 A COX2 inhibitor. SGTC_465 cgp-37157 41 µM 0.249921936194341 0.385687031951493 no 1272 0.401323859396315 1978 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_956 1185-0240 191 µM 0.249811973349759 0.385728974433109 no 1273 0.401366379936216 1870 1416193 SGTC_3296 9122258 64.045 µM 0.248670600594111 0.386164400356994 no 1274 0.401807795959802 1876 4730474 SGTC_1390 3413-2614 145 µM 0.248436847854177 0.386253593145211 no 1275 0.401898213283013 1845 3421432 SGTC_2567 aureobasidin a 60 nM 0.246620049514918 0.386947031572735 no 1276 0.402601143236851 1883 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_2684 capsaicin 100 µM 0.246509796826961 0.386989124631903 no 1277 0.402643810810407 1901 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1997 st073024 93.8 µM 0.246478879328068 0.387000928774239 no 1278 0.40265577602993 1980 686268 SGTC_1437 4092-1038 11.6 µM 0.245361377926682 0.387427655148586 no 1279 0.403088315526434 1869 3977136 SGTC_1201 1889-3372 45.9 µM 0.244292803867769 0.387835825500327 no 1280 0.403502028177509 1866 5392199 SGTC_2437 5741531 144.16 µM 0.244218902506591 0.387864058683853 no 1281 0.403530644070219 1995 2262990 SGTC_2761 levamisole 97.89 µM 0.244046438385461 0.387929948966609 no 1282 0.403597427187056 1981 26879 An alkaline phosphatase inhibitor. SGTC_1664 st014217 9.02 µM 0.243900943971865 0.387985537924905 no 1283 0.403653769035819 1989 3982782 SGTC_2221 6807166 181.081 µM 0.243079469752842 0.38829944109465 no 1284 0.403971917535562 1946 674925 SGTC_858 0438-0351 2.77 µM 0.242734485371976 0.388431288902682 no 1285 0.404105545386624 1849 2799119 SGTC_2804 7954240 19.48 µM 0.242362699779792 0.388573394121442 no 1286 0.404249567071047 1958 828705 SGTC_3077 9117319 49.47 µM 0.241929174651715 0.388739116479959 no 1287 0.404417521702504 1939 17154678 SGTC_210 3551-0445 56.827 µM 0.241381923797796 0.388948341344503 no 1288 0.404629560666368 1938 2865180 YOR207C RET1 SGTC_2439 5492030 7.2 µM 0.237931980112029 0.390268062556052 no 1289 0.405966925559214 2001 5722370 SGTC_1630 st005209 31.3 µM 0.236785684076945 0.390706840772027 no 1290 0.406411529111692 2041 3367314 SGTC_2693 st077581 40.7 µM 0.235370080411151 0.391248896382876 no 1291 0.40696075309515 2021 25238761 SGTC_2586 curcumin 80 µM 0.235002318377961 0.391389752530989 no 1292 0.407103466901023 1962 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_1499 4480-0877 67.3 µM 0.234932794127657 0.391416382542137 no 1293 0.40713044788194 1978 2861909 SGTC_575 k072-0246 11.9 µM 0.234849179210611 0.391448410403344 no 1294 0.407162897754519 1890 6796779 SGTC_3228 9131799 49.47 µM 0.233198109440448 0.392080986710288 no 1295 0.40780378691714 1909 17015818 SGTC_1427 4048-4900 550 nM 0.233137086142024 0.392104372116635 no 1296 0.407827478827029 2014 24132586 SGTC_208 k072-0098 12.366 µM 0.233038086470316 0.392142311693775 no 1297 0.407865915540738 1987 5948901 SGTC_2044 5102272 200 µM 0.232727545911033 0.392261326593347 no 1298 0.407986488950672 1898 592666 SGTC_2339 9000433 200 µM 0.231690184751476 0.392658969035866 no 1299 0.408389327704312 1815 2988954 SGTC_3098 9119039 49.47 µM 0.230688962399942 0.393042865001044 no 1300 0.408778224500056 1899 17161528 SGTC_1366 1683-0113 21.9 µM 0.230159447985808 0.39324593736132 no 1301 0.408983935893834 1862 708623 SGTC_357 1325-0123 420 µM 0.229910406212272 0.393341456613922 no 1302 0.409080694964204 2030 1098503 SGTC_1268 0828-0275 2.46 µM 0.229302704144079 0.39357456592347 no 1303 0.409316825934406 1955 745337 SGTC_2087 5276107 200 µM 0.22894149334813 0.393713141374078 no 1304 0.40945719493922 1892 144405 SGTC_80 0159-0065 512.242 µM 0.228887398565469 0.393733895536875 no 1305 0.40947821754443 2014 1548079 SGTC_589 1227-0070 34.1 µM 0.228740658417338 0.393790195811899 no 1306 0.409535245800121 1939 2841384 SGTC_3154 9100113 49.47 µM 0.22655592530561 0.394628681525197 no 1307 0.410384533807624 1854 25237525 SGTC_1334 1486-0610 236 µM 0.224015876012455 0.395604148968602 no 1308 0.41137247493636 1960 3742339 SGTC_2447 5741742 33.78 µM 0.223749069893708 0.395706649896221 no 1309 0.411476280755552 1944 1776504 SGTC_3162 9099653 49.47 µM 0.223196016560164 0.395919143550858 no 1310 0.411691476038098 2011 25237511 SGTC_2782 7736369 71.43 µM 0.222689948665655 0.39611361160828 no 1311 0.411888412374111 1876 2950836 YOL077C BRX1 SGTC_2828 7998861 71.43 µM 0.222420222080321 0.396217270727302 no 1312 0.411993385553162 2033 2988188 SGTC_3339 9145883 14.936 µM 0.222215078854696 0.396296114610027 no 1313 0.412073228160863 1997 2030670 SGTC_1139 k015-0024 46.9 µM 0.220467195139369 0.396968060588649 no 1314 0.412753659164227 2041 2766652 SGTC_2013 4024628 200 µM 0.220102415670961 0.397108332889784 no 1315 0.412895696753905 1949 5230760 SGTC_1101 ebselen 5.29 µM 0.217721115087528 0.398024364543937 no 1316 0.413823205424111 2038 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_2929 9013348 24.6 µM 0.217567739373708 0.398083383990636 no 1317 0.413882961296856 1925 2995952 SGTC_2310 7668677 200 µM 0.217049192923911 0.398282939522824 no 1318 0.414085004101676 1955 2197143 SGTC_48 0382-0018 55 µM 0.216023253056967 0.398677836840222 no 1319 0.414484811078164 2035 762596 SGTC_792 4534-1957 155 µM 0.215680905467893 0.398809633894264 no 1320 0.41461824307557 1925 1717904 SGTC_3273 9137859 49.47 µM 0.214270291045035 0.399352814134867 no 1321 0.415168142162533 2074 2377234 SGTC_669 0108-0021 26.2 µM 0.210502682224867 0.400804546523656 no 1322 0.41663767922425 2142 17201 SGTC_1075 aripiprazole 15.2 µM 0.210279844298799 0.400890453415916 no 1323 0.416724632763229 1903 60795 An atypical antipschotic. YIL048W NEO1 SGTC_482 fipronil 114 µM 0.210258333571581 0.4008987463322 no 1324 0.41673302667516 2042 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_1473 k844-0725 134 µM 0.210136038264553 0.400945895040211 no 1325 0.416780749448241 2021 54682906 SGTC_1412 3909-8563 178 µM 0.209794791360207 0.401077464140406 no 1326 0.416913919247405 2049 23767530 SGTC_1463 k081-0032 34.1 µM 0.209786687813335 0.401080588631544 no 1327 0.416917081729653 1988 977755 SGTC_3037 9091026 49.47 µM 0.209566189404549 0.401165608809348 no 1328 0.417003135284987 2002 25236398 YIL048W NEO1 SGTC_3145 9085516 49.47 µM 0.20790850206281 0.401804932501973 no 1329 0.417650205271784 1837 25236195 SGTC_1865 st057639 52.2 µM 0.207463686607562 0.401976530199177 no 1330 0.417823874793168 2032 688818 SGTC_439 amiodarone 34.4 µM 0.2060213747693 0.402533064670826 no 1331 0.418387107398009 1988 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_268 camptothecin 39.6153 µM 0.204544942627933 0.403102969558755 no 1332 0.418963837578989 2008 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2057 5236571 38.335 µM 0.202881530821008 0.403745295469066 no 1333 0.41961381517353 2037 54684039 YBR257W POP4 SGTC_1420 4'-methoxyflavone 42 µM 0.201382306751227 0.404324442895782 no 1334 0.420199824489559 2050 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_1587 estradiol valerate 56.1 µM 0.200796903076405 0.404550640234794 no 1335 0.420428692300065 2060 13791 A steroid. SGTC_830 4076-0286 57.8 µM 0.200087962418712 0.404824614415733 no 1336 0.420705893802323 1950 6866659 SGTC_2168 5727979 200 µM 0.198604947183309 0.405397884909134 no 1337 0.421285891706316 2030 695210 SGTC_2172 5754775 163.918 µM 0.19811762152241 0.405586308617766 no 1338 0.421476519054482 1896 2263357 SGTC_3157 9099274 49.47 µM 0.197833343347565 0.405696234439032 no 1339 0.421587728749719 2066 17217662 SGTC_1512 0259-0544 12.2 µM 0.19759652305818 0.405787814734216 no 1340 0.421680377683813 1959 18476 SGTC_1511 0906-3109 28.5 µM 0.196189467510624 0.406332040508503 no 1341 0.422230935787368 2045 2882180 SGTC_2789 5281112 71.43 µM 0.195916124411861 0.406437786120463 no 1342 0.422337908191141 1880 765948 SGTC_184 1494-0393 24.714 µM 0.195864107082613 0.406457910336733 no 1343 0.422358265742471 1892 3090647 SGTC_319 1348-1596 45.5 µM 0.19407648612089 0.407149646409606 no 1344 0.423057996461269 2068 5380505 SGTC_1670 st016595 4.04 µM 0.193668011225462 0.407307750198812 no 1345 0.423217920459707 2096 597879 SGTC_1810 st050138 53 µM 0.192294710484762 0.407839408888059 no 1346 0.423755680752914 2071 3444541 SGTC_1316 1272-0050 65.9 µM 0.192189256881918 0.407880241152685 no 1347 0.423796980403887 1974 7340392 SGTC_2565 isoliquiritigenin 100 µM 0.19215615224636 0.407893059671601 no 1348 0.423809945613834 1803 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_270 tamoxifen 5.46 µM 0.190801746090756 0.40841758664771 no 1349 0.424340460317813 2086 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_2512 diallyl trisulfide 49.23 µM 0.189813261811487 0.408800505064934 no 1350 0.424727731700061 2088 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_789 1309-1135 70.6 µM 0.189756877389746 0.408822349854991 no 1351 0.424749824354842 2058 3092424 SGTC_704 1310-0270 142 µM 0.188917185205664 0.409147701906604 no 1352 0.425078862129221 1925 5718033 SGTC_2374 9071832 200 µM 0.188868506681927 0.409166565094306 no 1353 0.425097938666303 2069 17381698 SGTC_2781 5567276 71.43 µM 0.188477612021634 0.409318046483652 no 1354 0.425251132010575 2021 2853274 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.188303528584978 0.409385512498492 no 1355 0.425319359712392 2060 91467 include heat shock SGTC_1219 1469-0211 33.1 µM 0.186869459381258 0.40994138778658 no 1356 0.425881492622604 2072 6822282 SGTC_2680 butyl paraben 22.24 µM 0.18682113300807 0.409960123261408 no 1357 0.425900438442566 2078 7184 An antifungal and steroid mimetic. SGTC_1022 4477-0945 21.3 µM 0.186657396740556 0.410023603103815 no 1358 0.425964630706097 1903 4648966 SGTC_234 nsc-17383 10.7 µM 0.185204310864558 0.410587061349315 no 1359 0.426534394002454 2066 408974 SGTC_644 1498-1197 63.3 µM 0.184596854977412 0.410822667265028 no 1360 0.426772626457287 2036 6741615 SGTC_2128 5255449 168.493 µM 0.18231354181959 0.411708552993662 no 1361 0.427668335972398 2000 736008 SGTC_3274 9138298 49.47 µM 0.182287808016594 0.411718539835125 no 1362 0.427678433091221 2094 17015756 SGTC_1077 5-fluorocytosine 377 nM 0.182276232985439 0.411723031922088 no 1363 0.427682974777594 1984 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_350 k064-0020 19.8 µM 0.182116134210882 0.411785164916945 no 1364 0.427745793597389 2098 2790705 SGTC_3110 9122132 49.47 µM 0.181341164167457 0.412085955546235 no 1365 0.428049898636948 2054 918317 SGTC_511 blebbistatin 171 µM 0.180192244342234 0.412531983039423 no 1366 0.428500823448413 2066 3476986 A myosin inhibitor. SGTC_1426 4048-4480 71.7 µM 0.179533098588805 0.412787924106202 no 1367 0.428759565297422 2069 14224343 SGTC_3052 9092717 49.47 µM 0.178559128268538 0.41316617690048 no 1368 0.429141944771952 1976 25237534 SGTC_215 1287-0124 461.5 µM 0.178466636879308 0.413202101212912 no 1369 0.429178260233647 2105 5560863 SGTC_2584 androsterone 48.74 µM 0.17657876955246 0.413935520686468 no 1370 0.429919635730499 2098 2754130 A steroid. SGTC_2893 9048488 25.97 µM 0.176354557554987 0.414022645029652 no 1371 0.430007701440877 1934 6467338 SGTC_3149 9097855 49.47 µM 0.176338932743367 0.414028716679874 no 1372 0.430013838664853 2081 25236625 YMR079W SEC14 SGTC_1700 st030840 7.9285 µM 0.175622515299278 0.414307131598029 no 1373 0.430295256312934 2112 5499307 SGTC_2612 dictamnine 15.46 µM 0.175396441666656 0.414394997522076 no 1374 0.430384068193435 1996 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_1660 st012960 28.1 µM 0.175002261607608 0.414548210043044 no 1375 0.430538928252084 1997 24207266 SGTC_2718 lomofungin 53.02 µM 0.173487541953067 0.41513708210736 no 1376 0.431134109742839 2080 5351222 A RNA synthesis inhibitor. SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.172866413295291 0.415378611250328 no 1377 0.431378216231071 2147 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_2154 5570129 200 µM 0.172180911060334 0.415645209516393 no 1378 0.431647652261998 2086 673366 SGTC_3230 9131665 49.47 µM 0.172051633602567 0.415695491091385 no 1379 0.43169846821753 2038 15943720 SGTC_2955 9076254 12.21 µM 0.171708635886984 0.415828904372929 no 1380 0.431833298100642 2098 16459619 SGTC_928 2764-0428 58.7 µM 0.171363127991873 0.415963303828802 no 1381 0.431969122745371 2013 662578 SGTC_1142 3253-1408 9.78 µM 0.171360801331854 0.415964208911905 no 1382 0.43197003741968 2122 256655 SGTC_751 0833-0568 350 µM 0.171216624446194 0.416020295355439 no 1383 0.432026718046447 1999 6954252 SGTC_3308 9128332 17.569 µM 0.170925578332817 0.416133520804287 no 1384 0.43214114200928 2102 17332805 YDL196W YDL196W SGTC_84 0443-0269 128.823 µM 0.17084831667209 0.416163579019146 no 1385 0.432171518170927 2083 6150058 SGTC_2716 st080858 38.6235 µM 0.170658970617256 0.416237245110625 no 1386 0.432245963080331 2093 5296050 SGTC_419 nsc-638432 893 µM 0.170176476736142 0.416424975222793 no 1387 0.432435675357967 2005 368090 SGTC_340 k038-0059 454 µM 0.169886490451212 0.416537813099234 no 1388 0.432549702868438 2024 23733424 SGTC_1750 st081859 2.357 µM 0.168328636635402 0.417144114150255 no 1389 0.433162373250459 2008 5291695 SGTC_2868 9035608 32.47 µM 0.16695157169203 0.417680218149812 no 1390 0.433704077099596 2079 6462614 SGTC_3229 9132204 49.47 µM 0.166804016376591 0.417737671880948 no 1391 0.4337621291769 2029 17682924 SGTC_517 1365-0151 113 µM 0.166115758106116 0.418005682731697 no 1392 0.434032926636851 2018 768657 SGTC_2941 9056145 11.23 µM 0.164968550718621 0.418452495004183 no 1393 0.434484367876855 2147 2119517 SGTC_1976 st070609 63.5 µM 0.163701601240198 0.418946066485096 no 1394 0.434983028473697 2112 682556 SGTC_2482 5981709 142.65 µM 0.16313345361767 0.419167443920581 no 1395 0.435206680210002 2048 877755 SGTC_838 0109-0203 71.4 µM 0.162713260453837 0.419331187703633 no 1396 0.43537210290218 2044 759422 SGTC_2883 9059145 45.46 µM 0.161033563506914 0.41998588292634 no 1397 0.436033482874237 2028 16476510 SGTC_3217 9129673 49.47 µM 0.160649251738117 0.420135707266246 no 1398 0.436184830689852 2039 17248312 SGTC_1235 benzylparaben 21.5 µM 0.160139429234053 0.420334479953449 no 1399 0.43638562095733 2061 7180 SGTC_2526 patulin 37.61 µM 0.159904452288184 0.420426101032622 no 1400 0.436478170616878 2029 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_2129 girgensonine 121.053 µM 0.158303027558906 0.42105063542306 no 1401 0.437109011289228 2038 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1882 5615643 20 µM 0.157033427481298 0.421545903906862 no 1402 0.437609251796171 2148 2253075 SGTC_1964 st076914 61 µM 0.156772589452989 0.421647671704297 no 1403 0.437712038069943 2140 24208661 SGTC_563 tetrahydrosecaminediol 614 µM 0.155707786698745 0.422063166230577 no 1404 0.438131679570313 2128 334274 A psychoactive constituent of the cannabis plant. SGTC_2773 thioridazine 9.09 µM 0.155205021123089 0.422259379549775 no 1405 0.438329844986826 2163 5452 An antipsychotic. SGTC_1519 esterone 74 µM 0.154987551068796 0.422344257135409 no 1406 0.438415565760446 1909 698 A steroid. SGTC_1215 3852-0577 11.2 µM 0.15447977530552 0.422542453769731 no 1407 0.438615728381676 2107 2884876 SGTC_680 0417-1641 114 µM 0.153981968182706 0.422736778451663 no 1408 0.438811976658131 2016 2835990 SGTC_2931 9014674 55.67 µM 0.152884178868162 0.423165379407881 no 1409 0.439244806331378 2063 2996810 SGTC_317 4495-0002 170 µM 0.15240330014037 0.42335315365467 no 1410 0.439434427174323 2002 15991618 SGTC_813 k007-0158 173 µM 0.151308079777479 0.42378088185906 no 1411 0.439866347961897 2109 6523916 SGTC_2677 mitomycin C 100 µM 0.15007006195512 0.424264486414955 no 1412 0.44035466978183 2069 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2457 5731572 11.68 µM 0.149925398173877 0.424321003609787 no 1413 0.440411736672843 2150 2865357 SGTC_455 paf C-16 10 µM 0.149889414657471 0.424335061878966 no 1414 0.44042593162341 2066 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_1442 4112-3290 3 µM 0.149575421769489 0.424457738701762 no 1415 0.440549800294489 2136 704353 SGTC_3316 9136639 10.545 µM 0.148824433706196 0.424751178925738 no 1416 0.440846085016838 2081 4903665 SGTC_1409 3909-8004 61.9 µM 0.148397005749237 0.424918210274619 no 1417 0.441014731488258 2047 2119279 SGTC_1903 st060211 78.3 µM 0.148096791902873 0.425035536641568 no 1418 0.441133190609607 2145 688960 SGTC_642 0335-0876 158 µM 0.147402277781234 0.425306984660859 no 1419 0.441407253876317 2044 6812350 SGTC_318 1488-0629 67.2 µM 0.147124332444718 0.425415628393883 no 1420 0.441516942174032 2028 3662576 SGTC_1370 2001-0092 44.6 µM 0.146634585128851 0.425607075411797 no 1421 0.441710226876738 2130 790957 SGTC_1055 3448-0672 86 µM 0.14550993360051 0.426046779013851 no 1422 0.442154136671486 2066 748378 SGTC_1768 st044301 37.178 µM 0.144816022249813 0.426318122575855 no 1423 0.442428065827338 2022 3931349 SGTC_2228 7354201 200 µM 0.143578243651214 0.426802223745224 no 1424 0.442916760839066 2108 753451 SGTC_640 3381-0960 37.1 µM 0.140952008010966 0.427829721488455 no 1425 0.443953927890774 2140 1745025 SGTC_2288 7946289 167.31 µM 0.138549196855619 0.428770234946901 no 1426 0.444903195510905 2152 1246052 SGTC_1203 3992-3522 103 µM 0.137497250730477 0.429182117604878 no 1427 0.445318882853157 2199 5322312 SGTC_207 4185-0010 4.486 µM 0.137373198966601 0.429230694357513 no 1428 0.445367907157138 2157 3761753 SGTC_1629 st005085 44.9 µM 0.135265178658089 0.430056325777177 no 1429 0.446201107705974 2032 24207091 SGTC_1848 st056003 16.4 µM 0.135067999375586 0.430133569108427 no 1430 0.446279055542475 2212 146492 SGTC_2948 9070189 9.45 µM 0.134591306214362 0.430320320699551 no 1431 0.446467507848396 2190 6473636 YDL196W YDL196W SGTC_1510 1123-0200 71.5 µM 0.133125918634243 0.430894505371589 no 1432 0.447046898737866 2149 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_435 c-PAF 6.7 µM 0.132333043771016 0.431205239524217 no 1433 0.447360436024906 2171 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_1697 st025554 27.742 µM 0.130678845980629 0.431853670073509 no 1434 0.448014683642177 2147 1269519 SGTC_2857 9024691 58.44 µM 0.129824460579206 0.432188653444071 no 1435 0.448352654973061 2063 16478292 SGTC_736 0958-0254 92.6 µM 0.129335552841942 0.432380364015768 no 1436 0.448546070287125 2124 6812352 SGTC_1159 4092-0538 61.2 µM 0.129186471511115 0.432438824978109 no 1437 0.44860505033781 2172 717301 SGTC_768 0384-0033 77.3 µM 0.128962355975469 0.432526712741588 no 1438 0.448693717806515 1988 3965305 YMR134W ERG29 SGTC_3099 9120367 49.47 µM 0.128815231080998 0.432584410146415 no 1439 0.448751926641883 2170 24824940 SGTC_635 k038-0028 24.7 µM 0.128305618207533 0.432784274175307 no 1440 0.448953559584886 2104 4035102 SGTC_3174 9107204 49.47 µM 0.12814732022549 0.432846360239487 no 1441 0.449016194299515 2138 3938802 SGTC_547 1120-0019 610 nM 0.127379314249302 0.433147603429677 no 1442 0.44932009385117 2090 3676939 SGTC_914 3820-6779 408 µM 0.127074678807035 0.433267104615143 no 1443 0.449440646177143 2132 2893481 SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.125953416414866 0.433707001466765 no 1444 0.449884399566408 2106 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_3257 9139206 32.98 µM 0.125209651591905 0.433998842738909 no 1445 0.450178788256692 2164 4910041 SGTC_369 0957-0393 4.5 µM 0.124698706339934 0.434199350240252 no 1446 0.450381040799434 2065 6997992 SGTC_3266 9136860 49.47 µM 0.124271174495862 0.434367137277677 no 1447 0.450550284887968 2176 4871271 YPR165W RHO1 SGTC_2954 9074818 52.69 µM 0.124130971060774 0.434422163401766 no 1448 0.450605788216272 2119 16648742 SGTC_923 1900-2434 73.3 µM 0.123795974179547 0.434553645921793 no 1449 0.45073840971714 2186 5910570 SGTC_1074 carmofur 3.8 µM 0.123609305963953 0.434626914245238 no 1450 0.45081231195329 2182 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1666 st014829 29 µM 0.12132266348912 0.435524615722432 no 1451 0.451717734870129 2159 3858230 SGTC_2571 chrysanthemic acid 100 µM 0.120930750524152 0.435678508354531 no 1452 0.451872942754514 2025 2743 An insecticide. SGTC_1155 4088-0394 48.2 µM 0.120441506075885 0.435870633848955 no 1453 0.452066706797389 2030 2326248 SGTC_1520 flindersine 88 µM 0.119958882343868 0.436060174228366 no 1454 0.452257859909539 2182 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_3352 9151559 45.5865 µM 0.118958278166862 0.436453187333506 no 1455 0.452654205099361 2102 17159339 SGTC_3201 9113999 49.47 µM 0.117573319938826 0.4369972688503 no 1456 0.4532028729477 2150 16649224 SGTC_1000 4048-0884 8.67 µM 0.117115657159952 0.437177088147399 no 1457 0.45338420125051 2112 13040088 SGTC_1811 st050069 61.5 µM 0.116499869199489 0.437419056542552 no 1458 0.453628194878141 2225 3877702 SGTC_2666 tannic acid 100 µM 0.115568429538212 0.437785101915001 no 1459 0.453997292394572 2197 16134267 A thiamine antagonist. SGTC_1310 1188-0297 994 nM 0.114309005441709 0.438280126120046 no 1460 0.454496421992033 2133 1588352 SGTC_846 0335-0850 148 µM 0.114108287465896 0.438359028469104 no 1461 0.454575976345149 2206 6819598 SGTC_467 ro 31-8220 72.8 µM 0.112669739108591 0.438924594160778 no 1462 0.455146196570467 2216 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_2704 st078022 71.1 µM 0.111915504772905 0.439221171513062 no 1463 0.455445201403328 2217 54697681 SGTC_178 4092-0806 87.505 µM 0.111670868942946 0.439317373683489 no 1464 0.45554218901954 2214 2169044 SGTC_1023 4482-3888 16 µM 0.111250401942003 0.439482729207605 no 1465 0.455708892342523 2208 3303168 SGTC_1996 st072960 66.8 µM 0.110671861082953 0.439710267115785 no 1466 0.455938280238646 2234 1719405 SGTC_2717 st081029 62.2815 µM 0.110007852983782 0.439971443506405 no 1467 0.456201573468518 2219 5292846 SGTC_3161 9100388 49.47 µM 0.108639205642037 0.440509860157503 no 1468 0.456744331584415 2142 25236368 SGTC_1990 st072050 59.8 µM 0.107457364167064 0.440974877186411 no 1469 0.457213073938743 2165 17233948 SGTC_2957 9076800 11.52 µM 0.105779035312744 0.441635385927794 no 1470 0.457878835425404 2120 16459615 SGTC_833 3852-0053 558 µM 0.103727714265645 0.442442906572819 no 1471 0.458692716240459 2178 3123681 SGTC_1383 3049-0032 20.7 µM 0.102676110065893 0.442856972809729 no 1472 0.459110017410068 2203 712864 SGTC_3260 9137109 49.47 µM 0.102580622010738 0.442894574064587 no 1473 0.4591479115446 2224 17478346 SGTC_3170 9103054 49.47 µM 0.102274176296179 0.443015249629224 no 1474 0.459269526068524 2134 16432970 SGTC_1870 st057514 26.5 µM 0.101624080103489 0.443271269147873 no 1475 0.459527532619942 2181 5393161 SGTC_3150 9097574 49.47 µM 0.100712101914887 0.443630462378248 no 1476 0.459889502141959 2214 17217476 SGTC_2197 6588183 93.1375 µM 0.100001406823276 0.443910410043763 no 1477 0.460171604280927 2226 884136 SGTC_2920 7982904 15.77 µM 0.099705929955676 0.444026808652027 no 1478 0.460288896290904 2140 6456808 SGTC_749 1000-0129 128 µM 0.0985407750173831 0.444485850646128 no 1479 0.460751447855927 2224 708470 SGTC_2345 9052315 157.45 µM 0.0984617816570652 0.444516974762997 no 1480 0.460782809136146 2125 6469265 SGTC_273 hydroxyurea 18.1 mM 0.0962709047993133 0.445380336226045 no 1481 0.461652709169312 2242 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_1778 st046819 58.9 µM 0.0948050558921177 0.445958129990659 no 1482 0.462234835471179 2228 671715 SGTC_788 1182-0090 188 µM 0.0931641064952396 0.446605079241554 no 1483 0.462886594599575 2222 5715185 SGTC_944 3370-0224 231 µM 0.0917632131117732 0.447157498224829 no 1484 0.463443086193121 2166 4580514 SGTC_2629 bisabolol 100 µM 0.0913500119674736 0.447320456847142 no 1485 0.463607240135353 2184 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_882 0843-0131 351 µM 0.0901975757268899 0.447775002549057 no 1486 0.464065105383006 2259 5425421 SGTC_460 trequinsin 123 µM 0.0900637875091337 0.447827775961761 no 1487 0.464118262807334 2251 5537 A vasodilator. SGTC_2751 anetholtrithion 17.25 µM 0.0897440594466089 0.447953897988787 no 1488 0.464245301401929 2212 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_288 1315-0019 35.1 µM 0.0888312132687802 0.448314014188163 no 1489 0.464608025569992 2197 6811474 SGTC_2023 5144124 124 µM 0.0872058615403639 0.448955317819734 no 1490 0.465253940136927 2196 2830192 SGTC_2300 7976697 71.57 µM 0.0869152674568898 0.449069989592775 no 1491 0.465369431885166 2170 2236109 SGTC_725 1497-0963 19 µM 0.0836444599379192 0.450360979111578 no 1492 0.466669558425987 2256 3549977 SGTC_2870 9038528 12.99 µM 0.0834069189399457 0.450454757302345 no 1493 0.466763993582612 2158 6463316 SGTC_2735 sertaconazole 140 nM 0.0798639842926193 0.451853788686843 no 1494 0.468172717334393 2282 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_1515 3460-0031 42.1 µM 0.0790883151870085 0.452160164736113 no 1495 0.468481188765006 2219 2876596 SGTC_338 4055-0136 114 µM 0.0788577207421095 0.452251251105636 no 1496 0.468572896214496 2258 2900563 SGTC_2203 7227154 166.4 µM 0.078647803896869 0.452334171868454 no 1497 0.468656381629287 2277 896304 SGTC_778 3456-2434 196 µM 0.0767984947547669 0.453064770209516 no 1498 0.469391924107678 2265 5539063 SGTC_220 paclitaxel 373.376 µM 0.0759492122805718 0.453400345855999 no 1499 0.469729752076912 2259 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_3318 9139014 38.6185 µM 0.0756124399746302 0.453533423394354 no 1500 0.469863719565397 2237 16643984 SGTC_2157 5649910 96.377 µM 0.0749648477605696 0.453789337880897 no 1501 0.470121340293812 2230 2858091 SGTC_438 sphingosine 6.67 µM 0.0746956111437364 0.453895740042728 no 1502 0.470228449859786 2218 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_1227 3909-8010 46.6 µM 0.0731254797030842 0.454516320796637 no 1503 0.470853133031077 2195 15982272 SGTC_255 tunicamycin 200.472 nM 0.0727687265291085 0.454657339911642 no 1504 0.470995078785687 2273 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_1013 4112-3890 241 µM 0.0717200852173984 0.455071884928696 no 1505 0.471412335815558 2135 705171 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.0710526336524419 0.455335764932079 no 1506 0.471677932854227 2211 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_1046 2001-0062 216 µM 0.0709501877756786 0.455376269121539 no 1507 0.471718699958719 2232 739778 SGTC_1341 1486-1360 280 µM 0.0700721864435297 0.455723424886797 no 1508 0.472068102136979 2263 3976547 SGTC_1760 st045453 10.4495 µM 0.0699883408543647 0.455756578636046 no 1509 0.472101469765719 2276 3323419 YIL048W NEO1 SGTC_2079 5212404 121 µM 0.069316164919277 0.456022377763255 no 1510 0.472368979470255 2287 758462 SGTC_1461 k072-0203 53.8 µM 0.0688820694295433 0.456194042995891 no 1511 0.472541745568656 2274 5418714 SGTC_1672 st016598 6.51 µM 0.067720007469122 0.456653626367549 no 1512 0.473004261107124 2147 4665860 YNL267W PIK1 SGTC_1258 0671-0043 57.1 µM 0.0664565401465315 0.457153380281447 no 1513 0.473507178559588 2221 4298767 SGTC_2165 5727197 32.143 µM 0.0659206665334506 0.457365361111145 no 1514 0.473720493427238 2184 1361712 SGTC_407 eburnamonine 100 µM 0.063920637545329 0.458156639020266 no 1515 0.474516709748094 2261 3195 SGTC_2796 7949634 45.45 µM 0.0633194755567519 0.458394511235593 no 1516 0.47475605381471 2260 2971588 SGTC_1732 st034308 51.822 µM 0.0631301952296856 0.458469410161652 no 1517 0.474831414965716 2248 830119 SGTC_3231 9132313 49.47 µM 0.0619188532030722 0.458948777487237 no 1518 0.475313726810011 2207 4905967 SGTC_1405 3909-7894 12 µM 0.061889799160165 0.45896027585017 no 1519 0.475325295508424 2295 7104060 SGTC_72 0744-0168 198.391 µM 0.0602001796910575 0.459629014610014 no 1520 0.475998101301673 2168 677577 SGTC_568 1193-0097 7.48 µM 0.0595344913349038 0.459892520561682 no 1521 0.476263197037174 2284 3646150 SGTC_2963 9082507 9 µM 0.0590753119189844 0.460074292328303 no 1522 0.476446061262691 2266 16459611 SGTC_1415 3966-0071 78.1 µM 0.0589470587947316 0.460125064382736 no 1523 0.476497137846541 2291 2893185 SGTC_2189 6047310 154.431 µM 0.05889055448733 0.46014743316522 no 1524 0.476519640711357 2270 711535 SGTC_643 k048-0106 28.4 µM 0.0587814629286609 0.460190620412675 no 1525 0.47656308668347 2266 6763920 SGTC_2407 paclitaxel 400 µM 0.0572874668135686 0.460782111748509 no 1526 0.477158101995608 2202 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2726 cimetidine 79.27 µM 0.0562982866453712 0.461173788108197 no 1527 0.47755209186543 2305 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_1372 2752-0194 270 µM 0.0549746530433877 0.461697953701451 no 1528 0.478079328594087 2306 823334 SGTC_1816 st051957 91.6 µM 0.0534433560009919 0.462304438022827 no 1529 0.478689330728793 2313 674121 SGTC_2384 9036245 200 µM 0.0532795436013239 0.462369322649669 no 1530 0.478754589444552 2271 6462766 SGTC_2143 5623677 140.463 µM 0.0531253891500643 0.462430382764086 no 1531 0.478816001198221 2307 5375313 SGTC_387 norethindrone acetate 66.7 µM 0.0528563625078698 0.462536945527687 no 1532 0.478923176718145 2242 541197 SGTC_975 1335-0046 28.5 µM 0.0524516350278996 0.462697265117164 no 1533 0.479084415952514 2261 16486740 SGTC_1389 3405-0187 19 µM 0.0522506902246623 0.462776865099175 no 1534 0.47916447155326 2250 799890 SGTC_3061 glucosamine 200 µM 0.0522341028280657 0.46278343590788 no 1535 0.479171079942895 2311 91431 and experimental redox chemotherapeutic SGTC_2531 methyl deoxycholate 70.07 µM 0.0518351692435696 0.462941469564805 no 1536 0.479330016102019 2272 16667744 Haematoxylin. SGTC_71 0417-1750 47.813 µM 0.0498756864301596 0.463717784063171 no 1537 0.48011072630078 2322 6811472 SGTC_247 mechlorethamine 29.705 µM 0.0489150711383507 0.46409841451956 no 1538 0.480493489104097 2297 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_196 k015-0023 18.111 µM 0.0488234372076008 0.464134724913185 no 1539 0.480530002127064 2272 5211998 SGTC_2505 galangin 7.89 µM 0.0479462299563834 0.464482337654496 no 1540 0.480879547778207 2300 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2725 haloperidol 53.21 µM 0.0467167867104866 0.464969577252778 no 1541 0.481369475546404 2319 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2478 5763493 32.33 µM 0.0467065796323706 0.464973622632018 no 1542 0.481373543141294 2288 1365576 YLR208W SEC13 SGTC_1273 0849-0096 14.1 µM 0.0463836775629241 0.465101600527936 no 1543 0.481502222964008 2270 5286025 SGTC_1665 st014639 11.4 µM 0.0452821108960387 0.465538218756504 no 1544 0.481941223123939 2326 981133 YIL048W NEO1 SGTC_710 3448-4187 58 µM 0.045019727876962 0.465642223328736 no 1545 0.482045792161759 2314 3946412 SGTC_3288 9119690 36.221 µM 0.0448227299053679 0.465720311821838 no 1546 0.482124303726775 2286 17595618 YKL019W RAM2 SGTC_2046 4110841 106 µM 0.0447385626750863 0.46575367547244 no 1547 0.482157847943468 2335 44119630 YMR134W ERG29 SGTC_1476 4112-3294 3.34 µM 0.0427579608842508 0.466538849357074 no 1548 0.48294723783724 2300 704369 SGTC_3015 9080845 49.47 µM 0.0425008688863526 0.466640778461517 no 1549 0.483049709553324 2310 5296973 SGTC_1285 0929-0069 65.5 µM 0.0423213607981541 0.466711949219105 no 1550 0.483121258542661 2297 1206237 SGTC_581 0958-0271 211 µM 0.0418539588761212 0.466897268135023 no 1551 0.483307559852135 2331 4591145 SGTC_3088 9117578 49.47 µM 0.0412851533900958 0.467122801950622 no 1552 0.483534284428921 2332 678341 SGTC_1356 1502-0781 85.8 µM 0.0407641789269663 0.467329379823816 no 1553 0.483741948341783 2311 567702 SGTC_1073 triclabendazole 3.09 µM 0.0405665864660292 0.467407731900364 no 1554 0.483820711177679 2263 50248 An antihelmetic and likely tubulin inhibitor. SGTC_135 0933-0004 26.348 µM 0.040174347053677 0.467563271798146 no 1555 0.483977064599961 2295 21230617 YGL099W LSG1 SGTC_1264 0783-0040 158 µM 0.0397679505786588 0.467724430807446 no 1556 0.484139063871105 2312 2855798 SGTC_363 0455-0021 3.06 µM 0.0397154917242929 0.467745234073262 no 1557 0.484159975405683 2334 4597466 SGTC_2927 9011802 47.9 µM 0.0374037484546631 0.468662073697953 no 1558 0.485081541964596 2283 43912568 SGTC_112 phenothiazine 287.218 µM 0.0370299769467023 0.468810327578923 no 1559 0.485230551989211 2339 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_1087 pterostilbene 9.05 µM 0.0366648790051833 0.468955145325607 no 1560 0.485376106148376 2321 5281727 Similar to reservatol, lowers cholesterol. SGTC_2321 7390090 138.78 µM 0.0361322398566016 0.469166426410598 no 1561 0.485588457708306 2294 649046 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.0358383552639778 0.469283004844014 no 1562 0.485705624810597 2332 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2088 5278280 127.392 µM 0.0355582024256806 0.469394138603317 no 1563 0.485817318430386 2310 791502 SGTC_1893 st059353 36.1 µM 0.0348339789041025 0.469681441679191 no 1564 0.486106062908653 2202 3112488 SGTC_3208 9114115 49.47 µM 0.0348140536154864 0.469689346364177 no 1565 0.486114007130244 2251 650895 SGTC_1493 4348-0038 111 µM 0.0342892702346995 0.469897540729265 no 1566 0.486323240476011 2339 800424 SGTC_2951 9072950 58.06 µM 0.034217444043348 0.469926036572556 no 1567 0.486351878175448 2351 16488155 SGTC_1037 k284-1091 78.7 µM 0.0336288632521029 0.470159551972653 no 1568 0.486586552866756 2330 3334711 SGTC_2555 cholic acid 100 µM 0.033299643704694 0.470290172055293 no 1569 0.486717818943009 2287 6708657 Influences liver metabolism. SGTC_3080 9117754 49.47 µM 0.0332928702422781 0.47029285950594 no 1570 0.486720519666071 2362 9550191 SGTC_2009 4012297 12.05 µM 0.0329123246819849 0.470443847589607 no 1571 0.486872252223099 2290 45595307 SGTC_1380 2291-0730 164 µM 0.0317766258079013 0.470894481091454 no 1572 0.48732509356209 2313 2999191 SGTC_91 0417-1751 58.384 µM 0.031663682767647 0.470939297762262 no 1573 0.487370128653963 2348 6795624 SGTC_2220 6782180 200 µM 0.0310376701031808 0.471187711081267 no 1574 0.487619748868189 2345 833803 SGTC_1145 3546-0597 10.2 µM 0.0287833092870516 0.472082375030331 no 1575 0.488518706312325 2267 875334 SGTC_679 0422-0091 41.4 µM 0.0287265569989586 0.472104899537852 no 1576 0.48854133784122 2357 627384 YHR062C RPP1 SGTC_3105 9121040 49.47 µM 0.028563825259466 0.472169486895879 no 1577 0.48860623178267 2368 41448907 SGTC_1960 st011366 51.8 µM 0.0274369826091307 0.472616744711265 no 1578 0.489055600743235 2358 3972846 SGTC_2159 5658611 73.75 µM 0.027295952622988 0.472672723703554 no 1579 0.489111842503132 2367 793844 SGTC_3200 9114385 49.47 µM 0.026456219764895 0.473006049765287 no 1580 0.489446726465426 2310 17018030 YLR208W SEC13 SGTC_1144 3486-0183 12.5 µM 0.0263253899624782 0.473057983444597 no 1581 0.489498901832537 2286 6744069 SGTC_1881 5652484 16 µM 0.0253082827097001 0.473461745856393 no 1582 0.489904533700714 2352 2255129 SGTC_2999 9069765 71.4286 µM 0.0251815807943122 0.473512044801637 no 1583 0.489955064347414 2350 2097066 SGTC_2376 9072922 81.32 µM 0.0248091720667527 0.473659888467011 no 1584 0.490103587529994 2327 17087968 SGTC_384 k007-0144 5.16 µM 0.0247849656254489 0.473669498381039 no 1585 0.490113241534333 2328 6824886 SGTC_1547 harmine 94.2 µM 0.0246750017131544 0.473713154050942 no 1586 0.490157097375689 2358 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_631 k072-0230 41.5 µM 0.0243061629486638 0.473859585331736 no 1587 0.490304198631217 2345 5773147 SGTC_541 4513-1321 94 µM 0.0235683404793925 0.474152516015115 no 1588 0.490598462885354 2334 747515 SGTC_3247 9135149 49.47 µM 0.022686036302916 0.474502827240419 no 1589 0.490950357193231 2365 8934436 YOR116C RPO31 SGTC_204 PMA1.184 62.41 µM 0.0226206245532011 0.474528799196938 no 1590 0.49097644601092 2372 2252213 YGL008C PMA1 SGTC_3311 9131146 2.8755 µM 0.0220278898512584 0.47476415143687 no 1591 0.491212854024164 2272 4900406 YPR165W RHO1 SGTC_2257 7960413 200 µM 0.0211474375341823 0.475113761549986 no 1592 0.49156402183157 2308 2974689 YIL048W NEO1 SGTC_2466 5983409 37.09 µM 0.0208111461571173 0.475247301242935 no 1593 0.491698153158879 2261 2879657 SGTC_1121 fusaric acid 630.51 nM 0.0200641931144184 0.475543922639278 no 1594 0.491996082073457 2353 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_77 0828-0286 12.516 µM 0.0199929436412248 0.475572217120834 no 1595 0.492024500800198 2366 745345 SGTC_1846 st056244 14.8 µM 0.019203161624301 0.475885862363124 no 1596 0.492339517728626 2314 5393182 SGTC_1265 0819-1001 68.8 µM 0.0184173263741653 0.476197955060872 no 1597 0.492652965169552 2373 3106768 SGTC_2853 9015042 58.44 µM 0.0180261022888805 0.476353334280491 no 1598 0.492809015088442 2368 6457456 SGTC_505 gw-5074 63.9 µM 0.0161855762809906 0.477084368560164 no 1599 0.493543171209086 2363 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_536 3852-0578 10.6 µM 0.0150447696191869 0.477537521799612 no 1600 0.493998231712662 2377 2869208 SGTC_2025 5147754 141 µM 0.0138408484413309 0.478015776987052 no 1601 0.494478476652884 2373 315777 YLR208W SEC13 SGTC_1132 3456-3614 2.5 µM 0.00904235978168744 0.479922274416715 no 1602 0.496392669527008 2384 3125502 SGTC_3029 9088683 49.47 µM 0.0087013914482739 0.480057763244285 no 1603 0.496528690857589 2370 25236615 SGTC_345 1362-0200 395 µM 0.00786747877550284 0.480389140497536 no 1604 0.496861362455149 2386 1419823 SGTC_2158 5657123 3.6195 µM 0.00755338112281804 0.480513959032242 no 1605 0.496986665563728 2392 2858827 SGTC_2124 5246320 200 µM 0.00668667576612743 0.48085838692776 no 1606 0.497332422200197 2388 579342 SGTC_2262 9014885 67.46 µM 0.0065155007080744 0.480926413433215 no 1607 0.497400709680314 2368 6457424 SGTC_1036 k216-0215 33.5 µM 0.0055146275636346 0.481324180464585 no 1608 0.497799993054983 2392 622330 SGTC_1509 1326-1131 80 µM 0.00430446084277205 0.481805149750606 no 1609 0.498282773878391 2384 768313 SGTC_572 0960-0087 17.7 µM 0.00426071021354149 0.481822538523518 no 1610 0.498300227694127 2395 6796365 SGTC_6 0844-0013 19.835 µM 0.00416079707263475 0.481862249325838 no 1611 0.498340086917024 2395 1584900 SGTC_456 gingerol 170 µM 0.00314660229543933 0.482265354450549 no 1612 0.498744689376235 2392 442793 A herb. SGTC_1913 st060213 96.1 µM 0.00298684007079702 0.482328855722823 no 1613 0.498808424982678 2398 688959 SGTC_810 3825-7150 143 µM 0.00235191946471427 0.482581224339875 no 1614 0.499061720750446 2402 22330411 YGL099W LSG1 SGTC_2387 9077560 195.08 µM 0.00179896884216929 0.48280101716922 no 1615 0.49928231565484 2401 5303272 SGTC_793 0488-0545 106 µM 0.000865221490152608 0.483172185056849 no 1616 0.499654826608733 2400 292548 SGTC_2170 morpholine 200 µM 0.00024139273462789 0.483420167348399 no 1617 0.49990369823291 2405 121171 Reacts with secondary amines. SGTC_981 1488-1094 54.9 µM -0.00112496014123947 0.483963337585847 no 1618 0.499551205930554 2407 3449522 SGTC_1613 st002381 52.1 µM -0.00192452600986462 0.484281205202243 no 1619 0.49923222567888 2407 551167 SGTC_542 3381-0244 89.3 µM -0.0020291171957329 0.484322786198217 no 1620 0.499190499914227 2411 1112843 SGTC_1923 st058458 19.1 µM -0.00323677270951161 0.484802910772649 no 1621 0.498708716768857 2413 3534982 SGTC_2126 5251174 33.877 µM -0.00368341336532359 0.484980486196649 no 1622 0.498530533995216 2417 790722 SGTC_2372 9071633 200 µM -0.0037039778436495 0.484988662295417 no 1623 0.498522330011303 2415 21321366 SGTC_116 0155-0182 31.788 µM -0.00439429818706908 0.485263125964111 no 1624 0.498246934302396 2410 771486 SGTC_1398 3558-0053 112 µM -0.00445933585235535 0.485288984576291 no 1625 0.498220988282129 2417 4532369 SGTC_911 3456-4043 236 µM -0.00561112936153044 0.485746941385954 no 1626 0.49776149500336 2424 914281 SGTC_13 0199-0087 65 µM -0.00649409130725819 0.486098022660918 no 1627 0.497409250614802 2416 4589825 SGTC_2052 5265182 7.135 µM -0.00776973620113238 0.486605260574549 no 1628 0.49690035490881 2417 1239884 SGTC_734 2023-0417 80 µM -0.0083547666681746 0.486837895020441 no 1629 0.496666969108662 2428 3935732 SGTC_2127 5253358 187.912 µM -0.00891575668566414 0.487060974109209 no 1630 0.49644317481881 2426 20612 SGTC_740 k014-0057 261 µM -0.00936819131412858 0.487240888827589 no 1631 0.496262687060289 2432 4012779 SGTC_163 TUB2.036 7.546 µM -0.0103538873554495 0.487632868707341 no 1632 0.495869470368379 2417 15992207 YJR013W GPI14 SGTC_1896 st058441 89 µM -0.0108646855657327 0.487836001588837 no 1633 0.495665702835809 2432 688759 SGTC_1514 1189-1591 158 µM -0.0109110918536784 0.487854456475871 no 1634 0.495647190502787 2426 767698 YMR146C TIF34 SGTC_2619 obliquin 87.91 µM -0.0110334075787348 0.487903099208704 no 1635 0.495598396525783 2434 6708593 A bioactive alkalod. YER133W GLC7 SGTC_1708 st033234 31.827 µM -0.0121812511112836 0.488359584314692 no 1636 0.495140504081485 2457 674664 SGTC_2540 epiandrosterone 100 µM -0.0136958118140287 0.488961932158869 no 1637 0.494536332411642 2432 441302 A steroid. SGTC_1556 plumbagin 1.48 µM -0.0145621572398617 0.489306493176796 no 1638 0.494190745098861 2435 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1298 1079-1278 263 µM -0.0156782788281427 0.489750406354243 no 1639 0.493745527926238 2439 2840950 SGTC_1897 st060201 15 µM -0.0158265648420069 0.489809384870607 no 1640 0.493686377704957 2447 611878 SGTC_726 3448-4391 34.2 µM -0.0158577512986478 0.489821788839849 no 1641 0.493673937669988 2439 1356692 SGTC_645 0845-0943 5.41 µM -0.0164971498094219 0.490076102649389 no 1642 0.493418887951061 2452 1885106 SGTC_2246 7293507 91.5585 µM -0.0165981880933548 0.490116289900667 no 1643 0.493378585026038 2427 887656 SGTC_2744 captopril 92.04 µM -0.0170258709404916 0.490286398785743 no 1644 0.493207988367805 2441 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_3193 9111931 49.47 µM -0.0174332907422904 0.490448449781433 no 1645 0.493045475507568 2454 17087244 SGTC_57 miconazole 162.5 nM -0.0185394051981716 0.490888414054156 no 1646 0.492604271079153 2427 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_1254 0550-0035 264 µM -0.0185580769385127 0.490895840957876 no 1647 0.492596823413798 2443 15121435 SGTC_2440 5628896 157.78 µM -0.0186997147207609 0.490952179149629 no 1648 0.492540327917834 2449 5522048 SGTC_3212 9128307 49.47 µM -0.0196529466806086 0.491331343671945 no 1649 0.492160113315314 2466 27243542 SGTC_2121 5257820 149.641 µM -0.0199959847642529 0.491467794945781 no 1650 0.49202328781013 2441 791256 SGTC_2059 5238311 157 µM -0.0202820544530323 0.491581586496764 no 1651 0.491909185657652 2441 703021 SGTC_2805 7950783 58.44 µM -0.0203970912557629 0.491627345527232 no 1652 0.49186330210522 2456 1178958 YDL195W SEC31 SGTC_2595 hexamethylquercetagetin 100 µM -0.0210258749518143 0.491877463348573 no 1653 0.491612507504657 2471 386331 SGTC_569 4130-2812 160 µM -0.0210987681456076 0.491906459039787 no 1654 0.491583433777285 2442 743552 SGTC_2539 epi(13)torulosol 80 µM -0.0219378938851199 0.492240252241197 no 1655 0.491248748546093 2466 6708597 SGTC_3091 9116372 49.47 µM -0.0227987483668124 0.492582694495472 no 1656 0.490905403212426 2540 17169793 SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.0260457286437553 0.493874369002494 no 1657 0.489610432312543 2529 61125 An anti-inflammatory. SGTC_681 1642-0006 26.6 µM -0.0265543503532937 0.494076708915975 no 1658 0.489407591773793 2450 4446530 SGTC_1701 st028638 40.4 µM -0.0267418065240374 0.49415128312613 no 1659 0.489332834129836 2460 3490878 SGTC_1272 0839-0021 27 µM -0.0276097512532652 0.494496573356341 no 1660 0.488986702127972 2487 5027250 SGTC_1775 st081588 35.1725 µM -0.0282437878161019 0.494748811659255 no 1661 0.488733856756812 2456 1426443 YGL099W LSG1 SGTC_906 1165-0455 526 µM -0.0283268686859581 0.494781863818798 no 1662 0.488700725541271 2446 3252859 SGTC_1090 efavirenz 20.7 µM -0.0292114456097668 0.495133778265988 no 1663 0.488347976426745 2474 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_895 0964-0006 13.7 µM -0.0319895575501381 0.496239027971882 no 1664 0.487240189252356 2452 6738897 SGTC_2317 5986382 200 µM -0.0329899786755817 0.496637045060661 no 1665 0.486841289575669 2476 877883 SGTC_109 0132-0036 33.701 µM -0.0332995997181545 0.496760228348147 no 1666 0.486717836481373 2452 67274 A color developer. SGTC_68 0986-0284 82.829 µM -0.0337950391361948 0.496957340447535 no 1667 0.486520295941737 2629 423278 YIL048W NEO1 SGTC_2256 7954252 200 µM -0.0347317166666863 0.497330002480521 no 1668 0.486146834967402 2526 2972920 SGTC_1729 st035615 45.989 µM -0.0356969061579337 0.497714010579467 no 1669 0.485762018754889 2575 17385451 SGTC_860 0443-0016 25.1 µM -0.0358183367083557 0.497762322819822 no 1670 0.485713605934616 2472 5337942 SGTC_973 1325-0077 65.9 µM -0.0358834052842786 0.497788210953524 no 1671 0.485687664005303 2507 2835149 SGTC_1079 idarubicin 2.36 µM -0.0360596265864922 0.497858322272098 no 1672 0.485617407346241 2467 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2925 9010536 32.5 µM -0.039571843826003 0.499255702201848 no 1673 0.484217237610844 2508 2994177 SGTC_1344 1488-0097 29.1 µM -0.0397551674502097 0.499328640217577 no 1674 0.484144159571822 2524 747966 SGTC_1604 st002052 72.4 µM -0.0402919544904508 0.499542209002075 no 1675 0.483930183979309 2573 6254834 YHR062C RPP1 SGTC_3113 9123498 49.47 µM -0.040595989851819 0.499663174098195 no 1676 0.483808990578857 2465 8897275 SGTC_1151 3909-8316 15.3 µM -0.0407009230829405 0.499704923389095 no 1677 0.483767162846559 2559 800431 SGTC_623 k072-0108 16.9 µM -0.0413978496518571 0.499982206343848 no 1678 0.483489363529291 2537 5382803 SGTC_2237 6667747 47.222 µM -0.0414872952547611 0.499982206343848 no 1679 0.483453710526439 2527 729940 YDL015C TSC13 SGTC_360 0957-0399 1.01 µM -0.041577008095421 0.499946512707025 no 1680 0.483417951135558 2510 6752301 YPR165W RHO1 SGTC_2777 climbazole 1.536 µM -0.0439996836512653 0.498982614983473 no 1681 0.48245232801723 2480 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_2389 9091542 195.52 µM -0.0441036363402993 0.498941255943282 no 1682 0.482410897113284 2523 3626624 YOL127W RPL25 SGTC_1497 4476-2978 41.3 µM -0.0442253941380023 0.49889281290455 no 1683 0.482362370128975 2548 1528379 SGTC_1746 st038117 42 µM -0.0453462490365578 0.498446866002251 no 1684 0.481915661964702 2535 2898218 SGTC_1183 1254-0324 198 µM -0.0456265596089343 0.498335341026113 no 1685 0.481803949852806 2520 5799357 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.0458295479934477 0.498254579705118 no 1686 0.481723053827177 2537 5379071 SGTC_351 caspofungin 25 nM -0.0459093111464246 0.49822284501409 no 1687 0.481691266391096 2508 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_2474 5321570 43.32 µM -0.0461818699592338 0.498114404430667 no 1688 0.481582646366056 2608 2841384 SGTC_322 k048-0136 19.3 µM -0.0463553016836701 0.498045402744179 no 1689 0.481513531138429 2556 6823282 SGTC_854 0422-0053 192 µM -0.0473909837701605 0.497633346718039 no 1690 0.481100807428507 2496 3596728 SGTC_1673 st016611 27.3 µM -0.0474144440793585 0.497624012837173 no 1691 0.481091458628617 2621 5226799 SGTC_115 0527-0192 112.043 µM -0.0481479785224462 0.497332170686133 no 1692 0.480799154593713 2538 4233931 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.0489516153451822 0.497012439424945 no 1693 0.480478927518984 2554 521171 SGTC_118 0083-0097 135.343 µM -0.0493555616941715 0.49685172789471 no 1694 0.480317970801717 2495 5207356 SGTC_2996 9066192 71.4286 µM -0.0494215508594098 0.496825473912175 no 1695 0.480291677021505 2520 6472854 SGTC_1098 clofazimine 15.1 µM -0.0497553061686596 0.496692688598491 no 1696 0.480158691524993 2587 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_745 0469-0705 296 µM -0.049878788507123 0.496643560959585 no 1697 0.480109490289515 2514 3486736 SGTC_2409 alverine citrate 63.97 µM -0.0511482291490599 0.496138515126334 no 1698 0.479603702478486 2772 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_972 1319-0219 195 µM -0.0515104000962225 0.495994426835671 no 1699 0.47945940738801 2528 23903702 SGTC_1305 1181-0477 144 µM -0.0519140415738083 0.495833840273728 no 1700 0.479298592902714 2533 6252086 SGTC_2541 muurolladie-3-one 83.07 µM -0.0519185245074217 0.495832056766765 no 1701 0.479296806879512 2639 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_969 1313-0238 134 µM -0.0519622701622022 0.495814652837329 no 1702 0.479279378413402 2510 5212874 SGTC_2510 benzyl isothiocyanate 8.31 µM -0.0524648191894691 0.495614717495345 no 1703 0.479079163465077 2478 2346 DNA damaging agent; causes G2/M arrest. SGTC_2755 lomerizine 42.69 µM -0.0530960894204686 0.49536357295976 no 1704 0.478827673625043 2524 3949 A calcium channel blocker. SGTC_1288 0973-0013 65.5 µM -0.0535692256998876 0.495175341631499 no 1705 0.478639187813171 2567 4315430 SGTC_874 0599-0792 117 µM -0.0535771070870805 0.495172206129539 no 1706 0.478636048103441 2493 765305 SGTC_1064 honokiol 6.76 µM -0.0553755367649417 0.49445673369399 no 1707 0.477919642379847 2550 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_2026 5148700 152 µM -0.0561351140112506 0.494154554967619 no 1708 0.477617085546598 2515 79838 SGTC_2889 9059656 51.95 µM -0.0564807466793187 0.494017054793092 no 1709 0.477479416481186 2565 3949838 SGTC_1280 0880-0253 10.1 µM -0.0568287772221079 0.493878601410253 no 1710 0.477340795033042 2530 6836607 SGTC_673 1082-0474 110 µM -0.0574000937424398 0.493651322088289 no 1711 0.477113244165664 2511 3098046 SGTC_2498 4'-Methoxychalcone 54.63 µM -0.0575394526508045 0.493595883080212 no 1712 0.477057739740045 2513 641818 YHR062C RPP1 SGTC_818 4072-2707 53.5 µM -0.0575416418951771 0.493595012167826 no 1713 0.477056867802554 2519 882871 SGTC_618 k072-0232 33.2 µM -0.0584644790482453 0.493227897262414 no 1714 0.47668932784505 2548 5872756 YGL099W LSG1 SGTC_2108 5365811 200 µM -0.0588900435256468 0.493058604883522 no 1715 0.476519844202409 2567 780283 SGTC_1120 ficusin 1.78878 µM -0.0591270094876604 0.492964338788079 no 1716 0.476425472905194 2640 6199 A DNA cross-linker. SGTC_391 gliotoxin 8.33 µM -0.0599371468298065 0.492642065612168 no 1717 0.4761028470861 2596 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_2874 9043904 71.43 µM -0.0600350613108269 0.492603115487334 no 1718 0.476063855076032 2582 4463428 SGTC_3132 9126706 49.47 µM -0.0616756481897539 0.491950505092025 no 1719 0.475410566485212 2664 850858 SGTC_3067 9117431 49.47 µM -0.0618809304673638 0.491868847167848 no 1720 0.475328826836339 2538 17150885 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.0619450705321678 0.491843333371432 no 1721 0.475303287648222 2504 66535 A nucleotide analog. SGTC_2940 9060638 45.86 µM -0.0623097231891701 0.491698281556971 no 1722 0.475158092769624 2567 4027022 SGTC_1362 1611-0397 101 µM -0.0627903855081836 0.49150708501021 no 1723 0.474966711007715 2521 27816 SGTC_1468 k284-1086 134 µM -0.0654190897963145 0.490461481859126 no 1724 0.473920162588034 2549 15996457 SGTC_327 1273-0057 3.96 µM -0.0660181983011299 0.490223187154623 no 1725 0.473681668455905 2525 3108138 SGTC_3306 9127676 59.7925 µM -0.0664289950708638 0.490059795233238 no 1726 0.473518143225623 2565 41905287 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.067031316750444 0.489820228465228 no 1727 0.473278386048555 2620 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_1195 1502-0147 41.1 µM -0.0671918788844453 0.489756367273542 no 1728 0.473214475113278 2518 817940 SGTC_1123 mangostin 811.285 nM -0.0675182604073375 0.489626554706703 no 1729 0.473084562746378 2594 5281650 An antioxidant. SGTC_977 1348-1378 135 µM -0.069403174511844 0.488876884872548 no 1730 0.4723343510598 2519 X977 SGTC_1756 st041558 35.5 µM -0.0696237131784185 0.4887891745408 no 1731 0.472246581175054 2557 3955792 SGTC_108 0509-0257 621.132 µM -0.0704394473985119 0.488464754003692 no 1732 0.471921947361579 2536 536624 SGTC_1070 indatraline 8.81 µM -0.0704618324314777 0.488455851499335 no 1733 0.47191303915994 2553 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_2544 sphondin 68.51 µM -0.0708421016844735 0.488304619694835 no 1734 0.47176171183994 2676 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_1829 berberine 14.4 µM -0.0710901129152312 0.488205987366154 no 1735 0.471663018506499 2679 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1228 0124-0032 52.5 µM -0.0719460393678919 0.487865596991524 no 1736 0.471322425419501 2575 X1228 SGTC_1977 st070720 65.3 µM -0.0729653960414099 0.48746022418074 no 1737 0.470916827021215 2634 682188 SGTC_3049 9092223 49.47 µM -0.073034290886242 0.487432826876181 no 1738 0.470889415090882 2624 8623917 SGTC_2667 digitoxin 100 µM -0.0738372091303091 0.487113536048364 no 1739 0.470569959607799 2556 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2234 tolnaftate 200 µM -0.0739099181964298 0.48708462275232 no 1740 0.470541031928512 2527 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_3126 9127922 49.47 µM -0.0750639332759385 0.486625729340512 no 1741 0.470081921955166 2721 45595682 SGTC_257 daunorubicin 18.5 µM -0.0751846935290729 0.486577710110514 no 1742 0.470033881338388 2665 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2964 9083345 53.42 µM -0.0757222107048971 0.486363973604145 no 1743 0.469820052567732 2574 17741579 SGTC_811 0416-0114 265 µM -0.0762079046562852 0.486170847275994 no 1744 0.46962684698685 2619 6612453 SGTC_655 k060-0012 42 µM -0.0778015734572677 0.485537180290914 no 1745 0.468992947403579 2547 5994525 SGTC_2736 butenafine 14.65 µM -0.0778333661144428 0.485524539412467 no 1746 0.46898030231299 2579 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_493 zm226600 134 µM -0.0785934545041605 0.485222329808543 no 1747 0.468677996992134 2679 5240098 A potassium channel opener. YCR052W RSC6 SGTC_38 0929-0051 58.268 µM -0.0787788375040536 0.485148623184216 no 1748 0.468604268474586 2599 1379719 SGTC_2031 5180455 200 µM -0.0799628074392935 0.484677899392129 no 1749 0.468133418288291 2547 29949 SGTC_1431 4049-0260 9.09 µM -0.0802872645706434 0.484548905144628 no 1750 0.468004393457528 2526 3854841 SGTC_1740 st038286 13.222 µM -0.0827793628934984 0.48355817786095 no 1751 0.467013489412089 2652 716786 SGTC_1606 st000094 49.2 µM -0.0835432459159629 0.48325451817092 no 1752 0.466709796143583 2539 1242210 SGTC_398 bronopol 33.3 µM -0.0840016178318233 0.483072310271829 no 1753 0.466527572736475 2567 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_226 1,3-diallylurea 8.28947 mM -0.0843954223067699 0.482915771465578 no 1754 0.466371023386648 2650 74537 YKL182W FAS1 SGTC_2622 2-methoxyxanthone 59.94 µM -0.0851171772025358 0.482628877948896 no 1755 0.466084117215709 2628 71034 A hepatoprotective. SGTC_1157 4092-0394 27.6 µM -0.0852650955410959 0.48257008234597 no 1756 0.466025320085013 2709 3659885 SGTC_405 ebelactone b 50 µM -0.0856798321195143 0.482405232011581 no 1757 0.465860467400076 2587 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_771 0250-0039 27.3 µM -0.0865423078553444 0.48206242307575 no 1758 0.465517662701196 2554 3005115 SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.0872859072149092 0.481766874667325 no 1759 0.46522212783882 2839 5282309 SGTC_1506 4226-2149 212 µM -0.0886140444009169 0.481239022930562 no 1760 0.464694323089606 2643 991114 SGTC_2930 9013230 14.89 µM -0.0887721478510991 0.481176188837769 no 1761 0.464631496536776 2614 2995857 SGTC_2865 9030313 51.95 µM -0.0907864734483815 0.48037568913231 no 1762 0.4638311291434 2565 42562754 SGTC_1445 4239-0156 97.7 µM -0.092604321411813 0.479653338134457 no 1763 0.463108955256792 2753 4008346 SGTC_3265 9137266 49.47 µM -0.0927111997771173 0.479610870361096 no 1764 0.463066499600451 2541 17224265 SGTC_2532 xanthone 78.9 µM -0.0942765274010258 0.478988919252513 no 1765 0.462444747637545 2637 7020 An insecticide. SGTC_2380 9035439 200 µM -0.0946549184210476 0.478838580893885 no 1766 0.462294463510916 2703 6462575 SGTC_1596 piperlongumine 63 µM -0.0956217016779501 0.478454482415039 no 1767 0.461910514365576 2672 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_3176 9106582 49.47 µM -0.096476830309758 0.478114760463455 no 1768 0.461570937404752 2556 17018027 SGTC_1934 st074720 32.6 µM -0.0974772524083382 0.477717337127847 no 1769 0.461173699069709 2581 17250992 SGTC_1197 1601-0112 267 µM -0.0988541318785978 0.477170400287609 no 1770 0.46062704395449 2564 7350313 SGTC_534 k292-0788 63.4 µM -0.0996547245772608 0.476852401130787 no 1771 0.46030922304505 2567 4146317 SGTC_1842 st055362 61.2 µM -0.0998262820583667 0.476784259609342 no 1772 0.460241121101062 2588 676032 SGTC_3158 9100007 49.47 µM -0.100368926423336 0.476568729257566 no 1773 0.46002571914408 2609 19297233 SGTC_2095 5432005 200 µM -0.100576094576296 0.476486446922151 no 1774 0.459943487112974 2621 783734 SGTC_1177 0983-0204 23.6 µM -0.101767355823903 0.476013325436496 no 1775 0.459470668682887 2641 766818 SGTC_3323 9138564 53.9225 µM -0.10206427313982 0.475895406951892 no 1776 0.459352829392654 2615 43912313 YNL103W MET4 SGTC_3214 9129694 49.47 µM -0.10279480053705 0.475605292484136 no 1777 0.459062915987626 2638 17158655 SGTC_2671 danthron 100 µM -0.102895742468501 0.475565206411444 no 1778 0.459022858392093 2623 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_747 3448-8087 38.7 µM -0.103062587320552 0.475498949504947 no 1779 0.458956648924851 2633 5168703 SGTC_926 2268-1401 59.4 µM -0.104484282629442 0.474934397973521 no 1780 0.458392520325483 2589 2931578 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -0.105024226794361 0.474720000665884 no 1781 0.458178292412175 2599 364106 SGTC_2301 7769476 200 µM -0.106422273365121 0.474164908138067 no 1782 0.457623660918355 2659 977820 SGTC_1658 st012944 20 µM -0.106895725155737 0.473976936049991 no 1783 0.457435852295844 2644 24207260 SGTC_606 k015-0008 38.6 µM -0.107310499436662 0.473812265146273 no 1784 0.45727132764827 2663 1970475 SGTC_912 3474-0017 2.18 µM -0.1075698620672 0.473709297005881 no 1785 0.457168452410715 2732 3360550 SGTC_46 0329-0187a 2.197 µM -0.108114351368935 0.47349313800657 no 1786 0.45695249206873 2656 46494817 SGTC_249 wiskostatin 11.211 µM -0.108205908346267 0.473456791198434 no 1787 0.456916179147264 2583 2775510 A n-wasp and actin depolymerizer. SGTC_720 r052-1644 49.9 µM -0.109196049503838 0.473063733525897 no 1788 0.456523496806663 2686 1422863 YOR257W CDC31 SGTC_1699 st031318 29.054 µM -0.109754994591066 0.472841859896217 no 1789 0.456301842222413 2693 5340658 SGTC_857 0438-0306 1.35 µM -0.110170072071643 0.472677100058209 no 1790 0.456137248395607 2666 4686136 SGTC_3324 9138759 60.749 µM -0.110533582891648 0.472532812802802 no 1791 0.455993108869588 2705 45595710 SGTC_2534 helenine 20.12 µM -0.111778063141044 0.472038872410526 no 1792 0.455499690790172 2610 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_2968 9090663 33.37 µM -0.111994158523864 0.471953107440109 no 1793 0.455414019127701 2715 25236811 SGTC_2811 7967822 32.47 µM -0.112088464678723 0.47191567916912 no 1794 0.455376631819455 2701 2232244 SGTC_901 1112-0062 60.1 µM -0.112313790699043 0.471826252677292 no 1795 0.455287303796028 2604 1908457 SGTC_1712 st032288 53.4 µM -0.112684226415082 0.471679238717499 no 1796 0.455140453544363 2612 2883011 SGTC_847 0342-0274 5.54 µM -0.113865531983861 0.471210442599004 no 1797 0.45467219465268 2717 18097 SGTC_475 α-linolenic acid 10 µM -0.114682595688727 0.470886217621057 no 1798 0.454348354763497 2819 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_32 0928-0142 34.1 µM -0.114705239227736 0.470877232547839 no 1799 0.454339380519674 2613 2244242 SGTC_3267 9137951 49.47 µM -0.115701554006707 0.470481904439799 no 1800 0.45394453730332 2589 16643986 SGTC_3302 9125395 16.351 µM -0.116201619939481 0.470283494034316 no 1801 0.453746376462852 2652 17599668 SGTC_2304 7443016 91.4 µM -0.116636463299786 0.470110967885519 no 1802 0.453574070691764 2588 939854 SGTC_633 0437-0093 97.7 µM -0.116931393784575 0.469993956019507 no 1803 0.453457210076273 2597 2831118 SGTC_3 0833-0587 95.581 µM -0.117385049693583 0.469813975873742 no 1804 0.453277465389913 2590 5382644 SGTC_850 0388-0143 75.9 µM -0.118199781481173 0.469490760617845 no 1805 0.452954681548671 2628 67273 SGTC_1263 0774-1208 64.8 µM -0.119102776975574 0.469132553437789 no 1806 0.452596965348852 2655 906585 SGTC_3315 9136395 68.55 µM -0.119723313844847 0.468886408578081 no 1807 0.452351165708292 2626 16876844 SGTC_1286 0929-0070 131 µM -0.121467207921506 0.468194731924309 no 1808 0.451660493319082 2718 1420408 SGTC_1115 galangin 695.678 nM -0.121796027136867 0.468064323817391 no 1809 0.451530280206013 2624 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2264 7948757 110.76 µM -0.122535160700984 0.46777119955944 no 1810 0.451237600789296 2612 2971411 SGTC_3336 9143619 71.43 µM -0.123975188641112 0.467200166201192 no 1811 0.450667460040585 2608 45595730 SGTC_1698 5-fluorocytosine 1.055 µM -0.124203723724609 0.467109548332426 no 1812 0.450576986982568 2635 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_3277 9138724 49.47 µM -0.124406013221335 0.467029338686782 no 1813 0.450496906237542 2694 15943418 SGTC_1972 st070201 17.4 µM -0.125600416257672 0.466555774297971 no 1814 0.450024116720012 2691 2829099 SGTC_3343 9148379 18.9835 µM -0.126122692571273 0.466348713755039 no 1815 0.449817402414282 2734 1955036 SGTC_1365 1672-3266 55.4 µM -0.127661520044561 0.46573868668996 no 1816 0.4492084217052 2677 6415873 SGTC_1590 st077108 57.8 µM -0.127871423344912 0.46565548233789 no 1817 0.449125363113779 2605 5489485 SGTC_2094 5332512 191.667 µM -0.128351691946628 0.465465112528876 no 1818 0.448935329550377 2749 755774 SGTC_446 go6976 132 µM -0.129663359099716 0.4649452317271 no 1819 0.448416386489162 2705 3501 A protein kinase C inhibitor. SGTC_824 1304-0008 100 µM -0.129790727701502 0.464894752206485 no 1820 0.448365999541216 2656 768245 SGTC_3347 9188721 44.724 µM -0.129912197853642 0.464846610922632 no 1821 0.44831794679264 2725 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_2809 7964133 12.99 µM -0.130270331718164 0.464704677619626 no 1822 0.448176275939314 2679 1253665 SGTC_254 nsc-64875 3.808 µM -0.130848448365785 0.464475571642488 no 1823 0.447947598091102 2784 56993 SGTC_1399 3562-5772 25 µM -0.131002852961696 0.464414383531644 no 1824 0.447886525259893 2626 23847490 SGTC_766 1391-0721 126 µM -0.131153861754834 0.464354541937987 no 1825 0.447826796791407 2811 1020919 YIL115C NUP159 SGTC_1715 st032160 10.2275 µM -0.133047270277567 0.463604293026185 no 1826 0.447077998251519 2705 5289825 SGTC_2324 6149169 200 µM -0.133103190950562 0.463582136833835 no 1827 0.447055885795047 2717 2888231 SGTC_1252 0493-0875 34.8 µM -0.133386282201002 0.463469975680257 no 1828 0.446943946841063 2635 3960963 SGTC_3189 9110682 49.47 µM -0.133553351862702 0.463403783806017 no 1829 0.446877886721426 2729 17122418 SGTC_545 4218-0007 221 µM -0.134027020438924 0.463216125021755 no 1830 0.446690603987431 2725 2840508 SGTC_688 0527-0193 473 µM -0.134668846233727 0.462961858505515 no 1831 0.446436852933047 2702 4007154 SGTC_1432 4049-0298 68.4 µM -0.136025480943059 0.462424462308572 no 1832 0.445900568650753 2727 741646 SGTC_1571 st070080 73.4 µM -0.136338382621783 0.46230052399626 no 1833 0.445776891107707 2772 4315245 SGTC_329 k048-0121 21.3 µM -0.136709690431784 0.462153456146389 no 1834 0.445630134798592 2728 6832902 SGTC_1714 st033236 13.627 µM -0.137701814111971 0.461760520561995 no 1835 0.445238042803173 2771 2916566 SGTC_146 3448-8650 53.125 µM -0.138227575249054 0.461552305318897 no 1836 0.445030281191522 2682 2891488 YIL048W NEO1 SGTC_2876 9059903 25.97 µM -0.138914271048007 0.461280371594106 no 1837 0.444758946822319 2640 6916095 SGTC_159 3970-0959 50 µM -0.140576039271996 0.460622381238904 no 1838 0.4441024390653 2743 6615653 SGTC_1798 st045719 60.953 µM -0.14227694750395 0.459949004741096 no 1839 0.443430627250626 2652 3980186 SGTC_3325 9138760 55.175 µM -0.143221641826669 0.459575057007802 no 1840 0.443057569156087 2687 43844959 SGTC_176 1486-1328 72.834 µM -0.143581713585106 0.459432535623219 no 1841 0.442915390731292 2729 22310231 SGTC_2199 6590217 200 µM -0.143688065071054 0.459390441229885 no 1842 0.442873398044068 2697 703109 SGTC_2986 9022445 71.43 µM -0.14420638793391 0.459185293249741 no 1843 0.442668748415231 2797 6459286 SGTC_3242 9133940 49.47 µM -0.14432378320955 0.459138830660494 no 1844 0.442622399312939 2815 17248444 SGTC_1925 st057770 10.1 µM -0.145197176731927 0.4587931773776 no 1845 0.442277597477539 2657 5989122 SGTC_1314 1222-0010 41.1 µM -0.147422186104958 0.457912751431255 no 1846 0.441399397431384 2720 3526027 SGTC_1657 st012939 43.4 µM -0.147606967795706 0.457839643394824 no 1847 0.441326477918586 2787 24207257 SGTC_3178 9107506 49.47 µM -0.148069155745857 0.457656787083621 no 1848 0.441144095617631 2791 8897194 SGTC_2793 7325131 81.82 µM -0.148260148615466 0.457581226820708 no 1849 0.441068732260387 2749 4176441 SGTC_2727 riluzole 51.77 µM -0.149024635305405 0.457278797319852 no 1850 0.44076709692842 2673 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.149501528683 0.457090151712221 no 1851 0.440578951604733 2771 616764 SGTC_324 1315-0088 19.6 µM -0.149619580761317 0.457043455121559 no 1852 0.440532379434602 2748 6787421 SGTC_2398 5228213 48.84 µM -0.150518119575867 0.456688049272909 no 1853 0.440177928117363 2756 80771 YMR134W ERG29 SGTC_2092 5303694 80.6725 µM -0.150685853061456 0.456621708208232 no 1854 0.440111766710771 2705 1963699 SGTC_1034 k072-0165 12.7 µM -0.152549295716942 0.455884770928494 no 1855 0.439376856501883 2833 5835461 SGTC_2416 tofa 880 nM -0.152809392598433 0.455781922200117 no 1856 0.439274295254486 2709 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_2039 Aminomethylbenzodioxan 200 µM -0.153990660983182 0.455314856905488 no 1857 0.438808549605071 2674 15053 SGTC_1688 st021091 57.6 µM -0.154314808892242 0.455186701850519 no 1858 0.438680760683726 2669 3656366 SGTC_2909 7941780 10.49 µM -0.154339881658682 0.455176789280543 no 1859 0.438670876506122 2692 1243215 SGTC_2213 7173844 200 µM -0.154711927836971 0.455029703338668 no 1860 0.438524213084118 2695 892728 SGTC_2855 9016525 58.44 µM -0.155041273538615 0.454899503885116 no 1861 0.438394389556857 2663 43811474 SGTC_55 0767-0285 6.563 µM -0.155848512722486 0.454580400455619 no 1862 0.438076215082534 2769 3116166 SGTC_1568 digitonin 820 nM -0.156858567683323 0.454181164807327 no 1863 0.437678156878619 2747 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_919 tnp00227 403.569 nM -0.157025870985407 0.454115040742518 no 1864 0.437612229462515 2741 1269246 A methoxyflavone. YNL221C POP1 SGTC_574 1315-0397 40 µM -0.157201674046084 0.454045558648813 no 1865 0.437542954504002 2678 6794277 SGTC_596 1155-0152 116 µM -0.158545672990981 0.453514420778002 no 1866 0.437013416952645 2670 280313 SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.158577110136179 0.4535019980555 no 1867 0.437001032018184 2851 1273210 SGTC_260 nsc-65238 3.989 µM -0.160005119514437 0.452937753113045 no 1868 0.43643852069463 2802 3246252 SGTC_647 0140-0236 81 µM -0.1610586108197 0.452521551178443 no 1869 0.43602361918665 2723 990837 SGTC_659 k018-0002 107 µM -0.162656863362402 0.451890230617751 no 1870 0.435394306311251 2778 6797879 YHR007C ERG11 SGTC_2597 laccaic acid a 100 µM -0.164071363505543 0.45133159490919 no 1871 0.434837482450863 2810 5491415 A textile dye. SGTC_2783 7738165 71.43 µM -0.164318892877084 0.451233846756938 no 1872 0.434740054738427 2757 17201110 SGTC_3137 9097352 49.47 µM -0.165863977595132 0.450623767337623 no 1873 0.434131998241298 2999 44120435 SGTC_3124 9127567 49.47 µM -0.167714091207854 0.449893400298324 no 1874 0.433404105018389 2890 17592030 SGTC_2140 5586273 200 µM -0.168143193814731 0.449724028150746 no 1875 0.433235314651549 2690 854421 SGTC_1209 2323-2347 50.3 µM -0.170432908515888 0.448820404784718 no 1876 0.432334846733995 2693 5412760 SGTC_2353 9059630 146.67 µM -0.172598431052444 0.447966037304485 no 1877 0.431483542614153 2823 4779114 SGTC_3036 9090181 49.47 µM -0.172607785711165 0.447962347114898 no 1878 0.431479865824376 2691 25236586 SGTC_156 3474-0145 5.642 µM -0.173022484853148 0.447798762731013 no 1879 0.431316876904447 2653 2265471 SGTC_2694 st077685 81.9 µM -0.173727743683714 0.44752058306074 no 1880 0.431039716379007 2700 2838096 SGTC_519 k048-0011 62.8 µM -0.17377368308959 0.4475024637863 no 1881 0.431021663772556 2835 6836379 SGTC_1071 trifluoperazine 6.31 µM -0.174758662021079 0.447113997944908 no 1882 0.430634635661127 2841 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_1755 st041960 45.185 µM -0.175156080032154 0.446957274598789 no 1883 0.430478496905518 2840 2257073 SGTC_2797 7859098 81.82 µM -0.177146961465621 0.446172287892548 no 1884 0.429696477638257 2755 972681 SGTC_2843 9000894 45.46 µM -0.178092973396697 0.445799357599948 no 1885 0.429324980119418 2688 2242070 SGTC_3222 9128301 49.47 µM -0.178292502168415 0.445720706856915 no 1886 0.429246633440169 2759 4911358 SGTC_2970 9090938 41.86 µM -0.178635744352782 0.445585411806136 no 1887 0.429111862982827 2947 17217104 SGTC_1717 st033143 58.0435 µM -0.178794090047706 0.445522999151147 no 1888 0.429049692984554 2853 674616 SGTC_63 0099-0242 26.702 µM -0.179060887154424 0.445417842947761 no 1889 0.428944946561535 2833 3898502 YLR359W ADE13 SGTC_2863 9028737 58.44 µM -0.181649945498096 0.444397584354007 no 1890 0.427928725003605 2840 6460917 SGTC_2821 7996764 71.43 µM -0.182276113592557 0.444150888159847 no 1891 0.42768302162374 2915 2987135 SGTC_99 0109-0120 622.8 µM -0.183574120609304 0.44363957150965 no 1892 0.427173783413929 2754 759414 SGTC_312 4092-0653 6.84 µM -0.184318054806746 0.443346559907392 no 1893 0.426881975443753 2828 1148278 SGTC_191 3914-0123 66.505 µM -0.184526044229364 0.443264645139326 no 1894 0.426800398803915 2739 3144412 SGTC_172 1112-0046 2.638 µM -0.185225595229482 0.442989151065556 no 1895 0.426526047171507 2788 2802135 YIL048W NEO1 SGTC_2081 5214970 32.255 µM -0.185422557215549 0.442911589335759 no 1896 0.426448808542733 2791 2063512 SGTC_757 1066-0008 322 µM -0.186680508620377 0.44241627193767 no 1897 0.425955569650898 2889 6842497 SGTC_92 0063-0024 660.874 µM -0.18724188556181 0.442195259196762 no 1898 0.425735492801837 2673 3594437 SGTC_3312 9133330 71.43 µM -0.187398249339489 0.442133702357169 no 1899 0.425674197557319 2891 17617324 SGTC_1206 3978-0017 132 µM -0.187894154762323 0.441938484994928 no 1900 0.425479812477902 3023 3873677 SGTC_79 0052-0007 94.094 µM -0.18837191412088 0.441750424320172 no 1901 0.425292557424398 2912 2801472 SGTC_3096 9117468 49.47 µM -0.188380781884079 0.44174693382173 no 1902 0.425289081914397 2865 41316311 SGTC_1920 st075728 45.7 µM -0.188428384294593 0.441728196801997 no 1903 0.425270425374968 2916 3400306 SGTC_1277 0873-0036 22 µM -0.188734046255489 0.441607886797597 no 1904 0.425150633026547 2807 5965735 SGTC_209 4077-0173 175.592 µM -0.189177611137068 0.441433307130608 no 1905 0.42497680727114 2838 15993494 SGTC_2074 5212007 75.395 µM -0.190014673025884 0.441103884691847 no 1906 0.424648816294062 2758 758611 SGTC_131 0141-0277 33.849 µM -0.190078271768321 0.441078857317675 no 1907 0.424623898147068 2906 1547771 SGTC_406 estrone 100 µM -0.190293622639359 0.44099411420084 no 1908 0.424539525372453 2920 5870 A steroid. SGTC_746 1095-0025 46.6 µM -0.190336486836839 0.440977246954037 no 1909 0.424522731930057 2911 6749286 SGTC_2471 5466956 24.79 µM -0.190550313113695 0.440893106990609 no 1910 0.424438960584076 2782 724419 SGTC_1814 st052110 31.539 µM -0.191710007136924 0.440436817634365 no 1911 0.423984683413344 2849 674163 SGTC_9 0092-0002 10.449 µM -0.193446498922638 0.439753731390561 no 1912 0.423304651114156 2785 759368 SGTC_2395 5646831 180.19 µM -0.194293991277762 0.439420417103419 no 1913 0.422972845127441 2904 6808628 SGTC_3293 9120939 62.045 µM -0.194400275125989 0.439378619250339 no 1914 0.422931237254995 2907 934087 SGTC_1418 3966-3099 2.4 µM -0.194493518462844 0.439341950347114 no 1915 0.422894735174094 2821 740335 SGTC_2205 7238770 200 µM -0.194535094524321 0.439325600300195 no 1916 0.422878459556816 2874 279867 SGTC_17 0960-0276 49.807 µM -0.194603797520383 0.439298582642978 no 1917 0.42285156495364 2734 6821114 SGTC_2976 9009005 19.48 µM -0.196328921214099 0.438620265645755 no 1918 0.422176363003104 2972 2993148 SGTC_2980 9014342 25.29 µM -0.197241742296042 0.438261418058361 no 1919 0.42181918327534 2929 2996599 SGTC_444 curcumin 90.4 µM -0.197414275567276 0.438193597593523 no 1920 0.421751679576862 2884 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_113 0099-0221 2.5 µM -0.19815980064065 0.437900562795534 no 1921 0.421460019105936 2899 89219 SGTC_374 0880-0231 82.3 µM -0.198982712473629 0.437577150033638 no 1922 0.421138133817866 2829 6833587 SGTC_999 SEC7.066 22.7 µM -0.199135611518889 0.437517063733285 no 1923 0.421078332538215 2776 740511 YDR170C SEC7 SGTC_3304 9125678 46.087 µM -0.200357383965143 0.437036983202765 no 1924 0.420600543169766 2788 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_2756 carbadox 75.1 µM -0.200820945504396 0.436854856589821 no 1925 0.420419292208245 2797 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_876 0720-0963 56.8 µM -0.200887121420026 0.436828858122004 no 1926 0.420393419029052 2960 765861 SGTC_904 1141-0088 396 µM -0.201783766690483 0.436476620902664 no 1927 0.420042886406723 2799 1378119 SGTC_604 1000-0114 314 µM -0.202293100692497 0.436276557062065 no 1928 0.419843796665101 2923 1572745 SGTC_1706 st031321 9.9705 µM -0.202729411365892 0.436105189380005 no 1929 0.419673266773606 2864 6103185 SGTC_1002 4049-0206 172 µM -0.203531842210007 0.435790053744316 no 1930 0.419359680006444 2760 4662749 SGTC_2152 5568786 200 µM -0.204732207525942 0.435318714967296 no 1931 0.4188906776997 2750 5399883 SGTC_525 k781-2675 26.7 µM -0.204872733350528 0.435263541701974 no 1932 0.418835779491151 2775 3651118 YDL195W SEC31 SGTC_205 1486-1330 71.903 µM -0.206573971295841 0.434595701756869 no 1933 0.418171294845929 2758 4118834 SGTC_2114 5491910 81.25 µM -0.206581163630649 0.434592878720303 no 1934 0.418168486094172 2892 2849228 SGTC_1200 1643-0193 18.4 µM -0.206624851363554 0.434575731082527 no 1935 0.418151425243293 2756 5403974 SGTC_2173 5763948 167 µM -0.20677338673457 0.434517431181312 no 1936 0.418093420643073 2751 2867177 SGTC_997 3996-0078 137 µM -0.206922132527896 0.43445905011666 no 1937 0.418035335656027 2831 735687 SGTC_225 nsc-122657 1.016 µM -0.207073898060417 0.434399485311134 no 1938 0.417976073308381 2896 275685 SGTC_784 4579-0127 173 µM -0.207928763598693 0.434063996278203 no 1939 0.417642294932354 2984 1948547 SGTC_2465 5809242 33.21 µM -0.20825154750608 0.433937333184228 no 1940 0.417516280834531 2756 2731748 SGTC_2688 kanamycin b 96.69 µM -0.208504688646516 0.433838003237134 no 1941 0.417417461038961 2894 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_1548 st061468 90.8 µM -0.208716313384597 0.433754967100019 no 1942 0.417334852182385 2895 390799 SGTC_1318 1280-3875 124 µM -0.209249208468081 0.433545885650325 no 1943 0.417126849885659 2838 373245 SGTC_417 st075190 100 µM -0.209280041219394 0.433533788985183 no 1944 0.417114815799884 2921 222757 SGTC_1325 1431-0015 227 µM -0.210416119941675 0.433088112815325 no 1945 0.416671456189831 2780 1103340 SGTC_282 k297-0036 65.7 µM -0.210461413269369 0.433070346302435 no 1946 0.416653782466843 2921 5061378 SGTC_2331 7980721 200 µM -0.211302309810577 0.432740525433081 no 1947 0.41632569032391 2853 2981221 SGTC_951 1171-0579 82.7 µM -0.211647321366572 0.432605216726108 no 1948 0.416191094205969 2732 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_1874 staurosporine 7.6 µM -0.211649464195373 0.432604376363299 no 1949 0.416190258274988 2910 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_358 0075-0058 9.45 µM -0.214148754086083 0.43162442712237 no 1950 0.415215528645182 2694 1069125 SGTC_658 3253-0951 102 µM -0.21422716861875 0.4315936882591 no 1951 0.415184955179415 2836 1184878 SGTC_501 nsc-95397 161 µM -0.216330720868225 0.430769241135097 no 1952 0.414364982090791 2967 262093 SGTC_333 3486-0131 40.1 µM -0.217241383243039 0.430412417755812 no 1953 0.414010117757452 2939 6744690 SGTC_1791 st048313 56.1 µM -0.217733891450458 0.430219462707166 no 1954 0.413818227785263 2933 1204976 SGTC_909 3448-9333 149 µM -0.218643971625001 0.429862955033161 no 1955 0.413463698508538 2784 3344074 SGTC_2163 5671233 125 µM -0.218720119057268 0.429833128223225 no 1956 0.413434037839082 2965 701023 SGTC_289 k017-0060 526 µM -0.220237294894862 0.429238936918351 no 1957 0.412843176240556 2802 5512909 SGTC_2004 4023728 41.89 µM -0.221265442915273 0.428836360975806 no 1958 0.412442877841818 2938 360084 YDR527W RBA50 SGTC_3300 9124615 50.48 µM -0.221378909113618 0.428791937307678 no 1959 0.412398706566678 2988 24824903 SGTC_772 k072-0172 35.3 µM -0.221577046450839 0.428714365819621 no 1960 0.412321576310563 2821 5861980 SGTC_56 0957-0365 83.25 µM -0.22206134744224 0.428524771817381 no 1961 0.412133063460262 2852 6752360 SGTC_2913 7966556 36.57 µM -0.222378023373338 0.42840080853809 no 1962 0.412009809170199 2870 2976516 SGTC_2763 lisinopril 49.32 µM -0.22253778111036 0.428338273806843 no 1963 0.411947632725167 2803 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_637 1181-0519 7.26 µM -0.222943758400866 0.42817936828413 no 1964 0.411789639530821 2805 6252091 YGR060W ERG25 SGTC_1335 1486-0900 202 µM -0.22315538197865 0.428096540298104 no 1965 0.411707288166024 2773 X1335 SGTC_2506 ethyl hematommate 54.16 µM -0.223240802005049 0.42806310839531 no 1966 0.411674048851531 2855 3940691 An allergen. SGTC_26 0302-0163 425.158 µM -0.22484280466222 0.427436208513072 no 1967 0.41105078260675 2808 3100915 SGTC_2266 7929956 200 µM -0.225238648989552 0.427281333834219 no 1968 0.41089681213881 2779 2967153 SGTC_979 1426-2828 121 µM -0.225985849028474 0.426989021274154 no 1969 0.410606213246245 2942 747872 SGTC_590 k048-0076 22.4 µM -0.226900035281937 0.426631436482623 no 1970 0.410250737309017 2925 6832814 SGTC_1833 st055984 71 µM -0.227084086261699 0.426559452055198 no 1971 0.410179179077089 2848 676288 SGTC_1425 4048-4433 7.33 µM -0.227333656306723 0.426461846285506 no 1972 0.410082152091078 2869 23734946 SGTC_3330 9141424 71.43 µM -0.227622395359898 0.426348927305226 no 1973 0.409969903981263 2939 27261020 SGTC_2706 st078239 82.5 µM -0.229105272816164 0.425769104498563 no 1974 0.40939354766965 2802 15434492 SGTC_1742 st038235 28.8875 µM -0.230676609623991 0.425154868159967 no 1975 0.408783023151859 2939 564103 YBR002C RER2 SGTC_2473 5854593 8.94 µM -0.232503600636966 0.424440924927425 no 1976 0.408073445466198 2769 2872951 SGTC_1296 1068-0102 11.9 µM -0.233720443876115 0.423965549823543 no 1977 0.407601007676412 2915 767053 SGTC_852 0418-0143 439 µM -0.234054619245508 0.423835019346758 no 1978 0.407471288012971 2927 5369229 SGTC_943 3253-1379 105 µM -0.234231015741257 0.423766121411522 no 1979 0.40740281879209 2985 668464 SGTC_2274 7947094 46.08 µM -0.235286074680798 0.423354079281969 no 1980 0.40699335128724 2806 2971028 SGTC_1705 st027868 56.3335 µM -0.236107989670741 0.423033147111674 no 1981 0.406674437162255 2900 292948 SGTC_2332 7982454 138.89 µM -0.237899646073152 0.42233373843744 no 1982 0.405979465013423 2892 2981748 SGTC_548 1436-0017 110 µM -0.23861607252533 0.422054135535138 no 1983 0.405701650510272 2953 9677137 SGTC_2208 7283366 200 µM -0.238896871696642 0.421944557515206 no 1984 0.405592775681966 2918 898663 SGTC_1988 st071872 53.4 µM -0.239724137237014 0.42162176365626 no 1985 0.405272060831081 2950 16414116 SGTC_1441 4106-0040 13 µM -0.239780733773327 0.421599681962589 no 1986 0.405250121770441 2818 2904180 SGTC_1940 st075990 51.1 µM -0.241088699135695 0.421089435272731 no 1987 0.404743185638328 3075 1084979 SGTC_555 4296-0685 37 µM -0.241477221230674 0.420937895498714 no 1988 0.404592634507207 2854 2908540 YHR072W ERG7 SGTC_612 0302-0167 22.4 µM -0.241724410251079 0.420841487596763 no 1989 0.404496856863255 2906 235821 SGTC_2993 9054257 71.4286 µM -0.242103976038316 0.420693459758104 no 1990 0.40434979870294 2812 6470217 YGL055W OLE1 SGTC_1868 st057644 42.7 µM -0.242496624809995 0.420540341452529 no 1991 0.404197685919124 2807 688665 SGTC_1469 k284-2957 126 µM -0.242716727487388 0.420454514914098 no 1992 0.404112424111013 2878 23884841 SGTC_2223 6903751 107.57 µM -0.243777405955821 0.420040968488629 no 1993 0.403701609969467 2936 5598863 SGTC_3278 9139605 49.47 µM -0.244588216180448 0.419724902339451 no 1994 0.403387644552289 3041 7958859 SGTC_1293 1000-1278 195 µM -0.244883854475471 0.419609670909021 no 1995 0.403273181700629 2982 678847 SGTC_1435 4092-0789 56.7 µM -0.245739156303317 0.419276337343587 no 1996 0.402942079532604 2934 2248285 SGTC_2572 astragaloside iv 100 µM -0.245743786961521 0.419274532812023 no 1997 0.402940287113701 3022 45006101 An anti-inflammatory agent. SGTC_81 0411-0046 9.971 µM -0.245780990658052 0.419260034881847 no 1998 0.402925886511628 2826 12925265 SGTC_1424 4048-1941 275 µM -0.246527903510834 0.418968993194979 no 1999 0.402636803479736 2961 X1424 SGTC_1578 josamycin 24.2 µM -0.247336061365691 0.418654136756928 no 2000 0.402324076311441 2849 5282165 A P450 substrate. SGTC_2182 6325192 200 µM -0.248454670719272 0.418218415142914 no 2001 0.401891319079362 2845 736248 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.249958409693087 0.417632835734449 no 2002 0.401309756046328 2897 676296 Flavone; oxidizing agent. SGTC_1323 1348-1351 11.2 µM -0.250837022305199 0.417290774710203 no 2003 0.400970058376794 2868 6989654 SGTC_1275 0867-0008 21.1 µM -0.253291394369632 0.416335572206513 no 2004 0.400021522817731 2835 3422836 SGTC_2611 pyromycin 23.93 µM -0.253625192082134 0.416205701483271 no 2005 0.399892566197883 2889 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_1552 6-methylflavone 10.6 µM -0.253753553712726 0.416155762240147 no 2006 0.399842978943302 2875 689013 SGTC_2258 7960471 200 µM -0.254668225439467 0.415799947365451 no 2007 0.39948967981809 2922 2974708 SGTC_868 0527-0199 213 µM -0.255025479243116 0.415660991404411 no 2008 0.399351710066946 2880 2849450 SGTC_1049 3226-0134 66 µM -0.256007525172367 0.415279073269667 no 2009 0.398972513329646 2853 5702385 SGTC_1824 st053723 68.6 µM -0.256045284411026 0.415264390279105 no 2010 0.398957935280923 2910 675225 SGTC_1694 st024011 44.9 µM -0.256090219832506 0.415246916925034 no 2011 0.398940586842451 2875 2787533 SGTC_3004 9076122 71.4286 µM -0.257325677986771 0.414766568875205 no 2012 0.398463685768495 3021 44782551 SGTC_1607 st000305 50.6 µM -0.258020179275769 0.414496601591779 no 2013 0.398195666788962 3013 5457690 SGTC_1839 st053978 48 µM -0.25888130715162 0.414161919138027 no 2014 0.397863410688601 2946 3788398 SGTC_601 0986-0029 62.9 µM -0.259112357807836 0.41407213052542 no 2015 0.39777427509245 2876 24747981 SGTC_3186 9110464 49.47 µM -0.259529686717355 0.413909963692442 no 2016 0.397613289893869 2987 17018021 SGTC_1369 1866-0067 208 µM -0.25991374080241 0.413760739853301 no 2017 0.397465155909217 3000 3531355 SGTC_2365 9042475 200 µM -0.260746896640758 0.41343706080415 no 2018 0.397143849180544 2984 6464479 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.261181306090011 0.413268317087914 no 2019 0.396976346752126 3068 688751 SGTC_1141 3253-0389 52.6 µM -0.262385131527572 0.412800782199665 no 2020 0.396512267280012 2963 5402031 SGTC_3069 9117009 49.47 µM -0.262537885728344 0.412741465218798 no 2021 0.396453390396545 2916 41904981 SGTC_628 1636-0253 16 µM -0.262586329420574 0.412722654148511 no 2022 0.39643471897351 2959 4456143 SGTC_853 0419-0306 21 µM -0.263208289580673 0.412481159901403 no 2023 0.396195020926559 2847 762713 SGTC_2520 obtusaquinone 4.71 µM -0.263921481630873 0.412204282979024 no 2024 0.395920211198046 3035 5967872 SGTC_1035 k081-0041 55.2 µM -0.264090596222154 0.412138635359163 no 2025 0.395855054936317 3014 731709 SGTC_3128 9127691 49.47 µM -0.264306808122331 0.41205470888706 no 2026 0.395771757319926 3014 41316314 SGTC_212 3807-4682 38.772 µM -0.264696165387498 0.411903583125886 no 2027 0.395621765871159 2946 3125501 YBL034C STU1 SGTC_1747 st037496 66.6 µM -0.26510809040529 0.411743712104169 no 2028 0.395463097512603 2901 723305 SGTC_2177 5811945 192 µM -0.265770005239677 0.411486848954768 no 2029 0.395208172507448 3036 5343475 SGTC_1926 methyl fluorone black 53.6 µM -0.267215387419363 0.410926084896609 no 2030 0.394651664668308 2879 72721 Reacts with homocysteine. SGTC_14 0354-0009 295 µM -0.268426241794613 0.410456450485254 no 2031 0.394185621204203 2857 1713507 SGTC_945 3381-0768 11.3 µM -0.268761734650301 0.410326351004973 no 2032 0.394056520757387 3020 1126236 YIL048W NEO1 SGTC_1343 1487-0095 224 µM -0.269097562897941 0.410196131347184 no 2033 0.393927302906576 2986 4560101 YGL055W OLE1 SGTC_2401 5128683 200 µM -0.269515129772588 0.41003423079946 no 2034 0.393766650475816 2905 708373 SGTC_3130 9127414 49.47 µM -0.269998871973443 0.409846691688038 no 2035 0.393580560711724 2853 1494646 SGTC_1671 st016596 74.5 µM -0.271342775769861 0.409325790042767 no 2036 0.393063704875903 2926 2829167 SGTC_1250 0485-0349 40.2 µM -0.271607714760106 0.409223117654443 no 2037 0.392961833435137 2907 6842794 YDL195W SEC31 SGTC_1 0258-0098 57.368 µM -0.272117638552672 0.409025523300072 no 2038 0.392765783756902 2938 6790032 YDR047W HEM12 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.272138645333758 0.409017383713764 no 2039 0.392757707892594 2942 4213774 SGTC_265 mycophenolic acid 32.932 µM -0.273417436152183 0.408521959243296 no 2040 0.392266175564737 3131 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_1608 st001473 40.5 µM -0.273818318918419 0.408366680759354 no 2041 0.39211212249986 2892 7292267 SGTC_293 4049-0273 38.5 µM -0.273849578703212 0.408354573155511 no 2042 0.39210011055702 2935 1380311 SGTC_2916 7875993 68.79 µM -0.273921570569683 0.408326689451175 no 2043 0.392072447220101 2919 1299250 SGTC_1563 conessine 56.1 µM -0.274129102073104 0.408246311481753 no 2044 0.39199270496083 3006 441082 An anti-amoebic, histamine inhibitor. SGTC_3250 9135583 49.47 µM -0.274453087444407 0.408120838076732 no 2045 0.391868225338693 3026 7699353 SGTC_2831 7999036 19.48 µM -0.274974076816201 0.407919088509739 no 2046 0.391668077292805 3164 2988270 SGTC_1237 0330-0133 46.1 µM -0.27663553375459 0.407275864001288 no 2047 0.391029988539543 2871 X1237 YHR072W ERG7 SGTC_2636 apigenin dimethyl ether 100 µM -0.276762335082981 0.407226783763795 no 2048 0.39098130203711 3038 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_980 1473-0395 201 µM -0.276867072788115 0.407186244660415 no 2049 0.390941088348325 2879 768876 SGTC_2035 5154463 94.595 µM -0.277008218352971 0.407131615337452 no 2050 0.390886897829215 3038 2769623 SGTC_2794 7785382 27.27 µM -0.277324750503577 0.407009110533455 no 2051 0.390765378218962 2939 2205081 SGTC_2341 7987486 176.74 µM -0.27877298154485 0.40644872992877 no 2052 0.390209525191994 3056 1258686 SGTC_552 k242-0005 476 µM -0.279194932945249 0.406285495429614 no 2053 0.390047616009164 3027 4088318 SGTC_1609 st001574 46.4 µM -0.280213430835618 0.405891550399692 no 2054 0.389656881479697 2892 3960012 SGTC_453 enantio-paf c16 10 µM -0.280389172882135 0.405823584721133 no 2055 0.389589471415254 2997 13871343 A lipid and platelet activating factor SGTC_1436 4092-1007 8.32 µM -0.281617802837332 0.405348509370886 no 2056 0.389118293906773 2924 2881121 SGTC_514 4466-0038 2.65 nM -0.28196683662632 0.405213573588672 no 2057 0.388984469741275 2941 5722064 SGTC_424 splitomicin 100 mM -0.28276081809111 0.404906663891809 no 2058 0.388680095836972 2985 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_3345 9148410 3.559 µM -0.283207754090824 0.404733928655373 no 2059 0.388508792341095 3039 4903596 SGTC_1015 4130-4525 82 µM -0.285205892057951 0.403961900510437 no 2060 0.387743203270695 2938 1363237 SGTC_128 0906-2981 13.371 µM -0.286387536063637 0.403505519994409 no 2061 0.387290659945219 3074 6740226 SGTC_898 1000-0849 28.3 µM -0.288224050616308 0.402796473025028 no 2062 0.386587619925123 3017 6751807 SGTC_3238 9133470 49.47 µM -0.288257943371596 0.402783390606007 no 2063 0.386574648857447 3043 3534688 SGTC_344 k064-0035 6.43 µM -0.288612979111726 0.402646355287954 no 2064 0.386438781049159 2913 5088750 SGTC_394 menadione 8.33 µM -0.288809753257702 0.402570410316511 no 2065 0.386363484000262 3064 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_1271 0832-2808 169 µM -0.291565884070403 0.401507069420316 no 2066 0.385309281551175 3073 3663794 SGTC_1193 1488-0126 41.5 µM -0.292106749988288 0.40129848363064 no 2067 0.38510250295347 2946 1384710 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.292330043279717 0.401212378421658 no 2068 0.385017145157627 2944 689007 SGTC_1009 4106-0057 9.87 µM -0.293313497946325 0.400833200849457 no 2069 0.384641268640294 3074 2928005 SGTC_609 0986-0026 86.3 µM -0.293823117202288 0.400636750432403 no 2070 0.384446534709131 2940 2848610 SGTC_1278 0874-0585 172 µM -0.294995696024285 0.400184834763991 no 2071 0.383998583781998 2996 766306 SGTC_3261 9137475 49.47 µM -0.2951231088724 0.40013573747826 no 2072 0.383949918590185 2982 17027690 SGTC_165 k038-0023 64.381 µM -0.29617916723129 0.399728856619914 no 2073 0.383546628813052 2941 46368543 SGTC_836 0330-0104 1.35 µM -0.296381839996315 0.399650782776838 no 2074 0.383469246125522 2934 46494820 SGTC_1805 st050013 60.3 µM -0.297275134265708 0.399306714752038 no 2075 0.383128231994396 2986 4037144 SGTC_2125 5246583 200 µM -0.297525112771156 0.399210445119202 no 2076 0.383032819171278 3075 835267 SGTC_1040 k898-0338 155 µM -0.299237934418654 0.398550982732719 no 2077 0.38237925353605 3139 20969351 SGTC_1575 cyproterone acetate 48 µM -0.300520814671508 0.398057243879274 no 2078 0.38188996096699 2998 9880 An androgen receptor antagonist and liver toxin. SGTC_1685 st024049 53.0905 µM -0.300762485643431 0.397964250832039 no 2079 0.381797808362753 3009 1941139 SGTC_3056 9094900 49.47 µM -0.301660495629978 0.397618754633121 no 2080 0.381455443011864 2984 25236784 SGTC_1483 3453-0561 55.9 µM -0.302232617434886 0.397398680997284 no 2081 0.381237370526923 3024 4546991 SGTC_2524 avocatin b 10.57 µM -0.302348299579551 0.397354186415205 no 2082 0.381193281188085 3039 6710748 SGTC_301 4119-0100 24.5 µM -0.302405893744955 0.397332034589462 no 2083 0.38117133119598 2958 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_3338 9144300 39.5675 µM -0.302469413949718 0.397307603878805 no 2084 0.381147123145557 3014 4901274 SGTC_2912 7964298 10.93 µM -0.303093361541718 0.397067646814489 no 2085 0.380909356539586 3013 2975850 SGTC_808 0711-0032 135 µM -0.304071082996987 0.396691714185813 no 2086 0.380536868411388 3048 4252555 SGTC_1680 diphenhydramine 100 µM -0.304915527689745 0.396367103548338 no 2087 0.380215244593123 2983 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_1026 k007-1105 30.6 µM -0.305406566741259 0.39617837760352 no 2088 0.380028260512177 2937 7066794 SGTC_305 1682-2595 20.8 µM -0.305910234774385 0.395984823111566 no 2089 0.379836496537961 2995 226033 SGTC_2436 5633522 8.09 µM -0.306562698385766 0.39573412612513 no 2090 0.37958812483319 3128 5724242 SGTC_2415 st077333 57.7 µM -0.307196451853334 0.39549065945292 no 2091 0.379346923029883 3192 2766255 SGTC_689 0833-0039 98 µM -0.308063507512164 0.395157632041241 no 2092 0.379017004248221 2988 5374726 SGTC_682 0kpi-0099 17 µM -0.309207807278436 0.394718235177056 no 2093 0.378581727686129 3040 1714895 YML126C ERG13 SGTC_2489 cantharidin 73.42 µM -0.312763472705518 0.393353760663553 no 2094 0.377230184307097 2923 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2928 9011484 9.79 µM -0.313226581158515 0.393176140351024 no 2095 0.377054262471285 3082 2994751 SGTC_3276 9139060 49.47 µM -0.313872107824759 0.392928592580633 no 2096 0.376809087683467 2927 4870619 SGTC_1109 tnp00067 928.257 nM -0.315097571938549 0.392458768506076 no 2097 0.376343786001903 2977 676295 SGTC_2010 4012422 159 µM -0.316390716319164 0.391963166772988 no 2098 0.375852981317309 3027 952393 SGTC_755 1995-0008 37.3 µM -0.317462567724541 0.39155250906471 no 2099 0.375446319106018 3072 689533 SGTC_1945 st075991 56.6 µM -0.317969244717862 0.391358428278388 no 2100 0.375254133142135 3001 1084980 SGTC_2284 7945075 39.21 µM -0.318267168739372 0.391244322184576 no 2101 0.375141143024609 3097 1245402 SGTC_764 1951-2361 146 µM -0.318818124177106 0.391033328710539 no 2102 0.374932216908662 2975 5438930 SGTC_1908 st060353 56.5 µM -0.319056475389613 0.390942059846028 no 2103 0.374841843846975 3180 4227716 SGTC_1063 disulfiram 1.84 µM -0.319179291014635 0.390895033931225 no 2104 0.374795279852034 2976 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_1185 1319-0113 81.3 µM -0.320291512362661 0.390469238803929 no 2105 0.374373678347455 3065 4672763 SGTC_3292 9120825 59.784 µM -0.321212722872539 0.390116668354775 no 2106 0.37402459557956 3134 24824900 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.321786267976289 0.38989720383486 no 2107 0.373807309011672 3115 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1149 3909-7961 23.3 µM -0.322518826531779 0.389616944561703 no 2108 0.373529838797298 3007 735261 SGTC_3008 9078912 71.4286 µM -0.322829709679651 0.389498025488652 no 2109 0.373412105810956 3006 16648731 SGTC_1557 sumaresinolic acid 42.3 µM -0.323406721432989 0.389277334288035 no 2110 0.37319361992882 2980 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_2714 st079313 56.9 µM -0.323878742095767 0.389096825856592 no 2111 0.373014919305316 2971 2939799 SGTC_2849 9019321 12.99 µM -0.324346287614067 0.388918052387567 no 2112 0.37283793984068 3110 16489627 SGTC_937 3122-0005 46.7 µM -0.326477285283055 0.388103529923507 no 2113 0.372031636181048 3135 759535 SGTC_1146 3579-1023 7 µM -0.326620926145566 0.388048644327285 no 2114 0.371977307054654 3098 X1146 SGTC_2585 alliin 100 µM -0.327383238428847 0.387757400009538 no 2115 0.371689021194866 3171 87310 A garlic compound which reacts with lipids. SGTC_1066 ketoconazole 628 nM -0.327901228503677 0.387559535940205 no 2116 0.371493172416644 3137 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_248 streptozotocin 5.23457 mM -0.328092623375958 0.387486433491541 no 2117 0.371420815636501 3079 5300 DNA alkylating agent. SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.329286776239207 0.387030422119051 no 2118 0.37096946916848 2983 229346 A bile salt which induces apoptosis. SGTC_364 0083-0097 67.7 µM -0.334429031995126 0.38506853624636 no 2119 0.369027917469309 3119 5207356 SGTC_2098 5376439 882.5 nM -0.336041128034363 0.384454088076061 no 2120 0.368419926158625 3095 2844116 SGTC_1623 st003709 20.3 µM -0.33738065239331 0.383943750888734 no 2121 0.367914983859981 2988 16192618 SGTC_150 3970-0969 77.2 µM -0.338351288601353 0.383574079794818 no 2122 0.367549238824568 3113 6615640 SGTC_1527 coumarin 137 µM -0.340817713672658 0.382635208272103 no 2123 0.366620407210346 3178 323 A hepatotoxic, DNA x-linker. SGTC_2850 9015429 58.44 µM -0.343054258465818 0.381784438928422 no 2124 0.365778820858978 3065 6457570 SGTC_2703 st077852 53.4 µM -0.343212210487963 0.381724376374875 no 2125 0.365719409669293 3124 6281836 SGTC_120 rhodamine 6G 52.259 µM -0.344079886340568 0.381394486325052 no 2126 0.365393104404252 2981 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_2419 paclitaxel 166.5 µM -0.345593056281012 0.380819385905613 no 2127 0.364824282541468 2921 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_865 0488-0499 301 µM -0.346296950549172 0.380551951119662 no 2128 0.364559780059855 3179 9634651 SGTC_2303 7774051 200 µM -0.346360647539491 0.380527753152925 no 2129 0.364535847808895 3207 2953184 SGTC_1043 0916-0009 19.3 µM -0.347226596259052 0.380198832712615 no 2130 0.364210545730464 3191 3101130 SGTC_2018 5133068 143 µM -0.347859533363638 0.379958473772953 no 2131 0.363972838589095 2965 785362 SGTC_2470 5664817 21.68 µM -0.347951999607824 0.379923363438832 no 2132 0.363938116158065 3000 2859561 SGTC_1134 3477-0009 42.5 µM -0.34837207629415 0.379763868692372 no 2133 0.363780385270263 3253 3973534 SGTC_661 1304-0007 33.6 µM -0.348495565887711 0.379716986043334 no 2134 0.363734021641349 3039 3117130 SGTC_2178 5812956 200 µM -0.349052623771308 0.379505521794308 no 2135 0.363524901500034 2967 5403383 SGTC_558 k064-0027 21.3 µM -0.349932461753307 0.379171600710903 no 2136 0.363194692199018 3114 5088526 SGTC_1189 1431-2119 7.28 µM -0.350728956986746 0.378869388062212 no 2137 0.36289584966709 3044 3107275 SGTC_2593 nobiletin 86.24 µM -0.351464945711251 0.378590199092736 no 2138 0.362619783185778 3081 72344 An anti-infammatory. SGTC_2239 6685329 187.64 µM -0.35154812620188 0.378558649499782 no 2139 0.362588586998746 3152 805680 SGTC_3021 9087658 49.47 µM -0.35192752894836 0.378414755805791 no 2140 0.362446306563189 3135 25237042 SGTC_3048 9093155 49.47 µM -0.353286608813623 0.377899444617369 no 2141 0.3619367918617 3140 25236002 SGTC_2618 avocadyne 43.43 µM -0.353550704307519 0.377799334865011 no 2142 0.361837811659942 2965 3015189 SGTC_1912 st060209 90.8 µM -0.356183304544414 0.376801854008538 no 2143 0.360851647098246 3082 688787 SGTC_1915 st067105 30.6 µM -0.356840529069819 0.376552962408163 no 2144 0.360605596602738 3045 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_1720 st037298 9.481 µM -0.358753550533965 0.3758287916009 no 2145 0.359889731917135 3133 597396 SGTC_262 fenpropimorph 62.5 µM -0.3602220113621 0.375273204820653 no 2146 0.359340557697145 3070 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2829 7992743 58.44 µM -0.361218518086132 0.374896327379649 no 2147 0.35896804997679 3179 16462845 SGTC_1387 3342-1166 1.8 µM -0.36165183845861 0.374732483462119 no 2148 0.358806110751775 3093 3418228 SGTC_1332 1480-0653 17.5 µM -0.362493774093952 0.374414201609715 no 2149 0.358491537598367 3184 5749438 SGTC_443 clozapine 122 µM -0.363493481420124 0.374036387527662 no 2150 0.358118140744267 3109 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1880 MG-132 525 µM -0.363705779904431 0.373956170248889 no 2151 0.358038863403374 3167 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_2965 9082772 38.63 µM -0.364915739481603 0.373499089634316 no 2152 0.357587152455319 3240 16459634 SGTC_666 0272-0154 136 µM -0.365109516661873 0.373425903871388 no 2153 0.357514828652367 3079 6870312 SGTC_2649 anisomycin 9.56 µM -0.365277182722179 0.373362583439793 no 2154 0.357452254478221 3107 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_591 4299-0174 154 µM -0.367239995397201 0.37262156624564 no 2155 0.356720004165636 3101 5509088 SGTC_1600 coumarin 106 71.1 µM -0.370455686639751 0.371408571453011 no 2156 0.355521494224293 3213 100336 A hepatotoxic, DNA x-linker. SGTC_812 4251-0442 148 µM -0.371718496356171 0.370932573721528 no 2157 0.355051226082836 3193 5723007 SGTC_719 2810-4230 27.3 µM -0.371758939658786 0.370917332466528 no 2158 0.355036168711104 3084 721079 SGTC_2298 7976326 193.81 µM -0.371803646359357 0.370900484764961 no 2159 0.355019524304952 3023 2235818 SGTC_840 0245-0196 390 µM -0.372710220788274 0.370558896002326 no 2160 0.35468206431411 3197 3827528 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.372840304698381 0.370509889965704 no 2161 0.35463365169658 3218 688798 SGTC_709 3807-1509 243 µM -0.373169378605469 0.37038592853643 no 2162 0.354511192544238 3115 1886677 YPL242C IQG1 SGTC_2749 bexarotene 57.39 µM -0.373371507135799 0.370309793827404 no 2163 0.354435981368204 3130 82146 An retinoic acid receptor inhibitor. SGTC_839 0122-0028 230 µM -0.373496365336916 0.370262766672185 no 2164 0.35438952499246 3067 759448 SGTC_1817 st052116 64.4 µM -0.373642031191721 0.370207904879464 no 2165 0.354335329386946 3194 4361398 SGTC_2181 6316240 54.2555 µM -0.373796846544862 0.37014960002682 no 2166 0.354277732904731 3142 12779990 SGTC_2827 7993847 71.43 µM -0.374472483359413 0.36989518407426 no 2167 0.354026412471397 3139 2985692 SGTC_2116 5511452 16.8835 µM -0.374903842708578 0.36973278234652 no 2168 0.35386599055053 3188 870744 SGTC_2151 5563267 85.4165 µM -0.375253477255032 0.369601166092813 no 2169 0.353735980999422 3098 5310824 SGTC_33 0986-0033 35.816 µM -0.375911096496493 0.369353653636977 no 2170 0.353491495371018 3121 2848082 SGTC_506 n9-isopropylolomoucine 153 µM -0.376396921238559 0.369170835368803 no 2171 0.353310917250465 3191 6610355 SGTC_1992 st073643 23.3 µM -0.376526616157988 0.369122035527155 no 2172 0.35326271601497 3045 3161292 SGTC_777 1315-0167 517 µM -0.376699760384776 0.369056890458386 no 2173 0.353198370473439 3131 4221767 SGTC_2329 6138490 200 µM -0.37952710769887 0.367993641718513 no 2174 0.352148239152337 3247 720019 SGTC_1637 st007924 17.4 µM -0.379784120562267 0.367897039763486 no 2175 0.352052835352567 3043 683336 SGTC_1861 st057647 17.4 µM -0.380862994881572 0.367491620653399 no 2176 0.351652456231601 3244 688668 SGTC_232 clozapine 119 µM -0.381152951853544 0.367382685851747 no 2177 0.351544878844845 3106 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1287 0971-0001 34.6 µM -0.381576544252228 0.367223564342281 no 2178 0.351387742542913 3110 4665869 SGTC_1782 st039423 80.636 µM -0.3820864818344 0.367032037711614 no 2179 0.351198609228118 3104 2068169 SGTC_2430 5571206 200 µM -0.384399642767642 0.366163657450992 no 2180 0.35034113262668 3233 1731771 SGTC_2769 toremifene 3.73 µM -0.385822349693357 0.365629901102129 no 2181 0.3498141209122 3282 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.386349300238614 0.365432271235779 no 2182 0.349618996566235 3185 368090 SGTC_2483 5729050 27.16 µM -0.386580353372276 0.365345627307861 no 2183 0.34953345250035 3261 2865180 SGTC_2311 7694451 200 µM -0.38753091037373 0.364989244868768 no 2184 0.34918160299808 3122 2163142 SGTC_1446 4239-0190 62 µM -0.388742504834298 0.36453516342337 no 2185 0.348733318141876 3094 1340085 SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.39000079825264 0.364063781275275 no 2186 0.348267978327964 3049 23665772 A membrane-active detergent. SGTC_1759 st043059 70 µM -0.390145184094901 0.364009704556538 no 2187 0.348214596404689 3062 669426 SGTC_330 1488-0319 80.1 µM -0.391901556247144 0.363352108953478 no 2188 0.347565476531925 3166 6846614 SGTC_202 3594-0513 34.79 µM -0.392764992360418 0.363028981070878 no 2189 0.347246531539456 3112 708429 SGTC_3234 9132280 49.47 µM -0.392956901174499 0.362957175337862 no 2190 0.347175656952354 3164 17612295 SGTC_648 0375-0473 33.3 µM -0.393748592825335 0.362661002280719 no 2191 0.346883330770727 3100 1713139 SGTC_1799 st045822 46.1415 µM -0.395839467101829 0.361879198425362 no 2192 0.346111729659196 3235 3674992 SGTC_2591 skatole 100 µM -0.396805655837421 0.361518122854969 no 2193 0.345755389833811 3207 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_87 0100-0052 35.5 µM -0.39711222266548 0.361403581142733 no 2194 0.34564235353094 3223 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_795 0685-0265 78 µM -0.39821366435574 0.360992155093607 no 2195 0.345236347203587 3112 302754 SGTC_2183 6420625 130.508 µM -0.398232597297049 0.360985084398378 no 2196 0.345229369820245 3173 2897619 SGTC_3279 9140807 49.47 µM -0.399795390655583 0.360401607680831 no 2197 0.344653612984735 3153 45595718 SGTC_566 0958-0068 16.5 µM -0.399915382576221 0.360356821512532 no 2198 0.344609420987543 3261 6815365 SGTC_1727 st034309 9.9045 µM -0.400228821851557 0.360239841475466 no 2199 0.3444939939914 3320 870305 SGTC_2481 5478948 45.16 µM -0.400324012336372 0.360204317609683 no 2200 0.344458942055348 3248 77792 SGTC_2146 5545642 200 µM -0.403329920724233 0.35908317353195 no 2201 0.343352766622173 3198 825326 SGTC_1421 4029-0249 71.4 µM -0.40375954999827 0.358923029171166 no 2202 0.343194772162499 3266 2894095 SGTC_3034 9090421 49.47 µM -0.404054868229961 0.358812963642939 no 2203 0.343086185946671 3170 17173761 SGTC_2798 7813637 45.45 µM -0.404264459679744 0.358734855720683 no 2204 0.343009128661626 3239 956368 SGTC_1902 st060212 70.5 µM -0.405592985050761 0.358239895008478 no 2205 0.342520842010757 3230 688944 SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.408742317354086 0.357067519812501 no 2206 0.341364387536137 3231 688801 SGTC_2943 9068529 45.32 µM -0.410833251475912 0.356289889521754 no 2207 0.340597404645359 3156 3270634 SGTC_1965 Pectolinarigenin 58.4 µM -0.41175749494429 0.355946348261842 no 2208 0.340258589377575 3133 5320438 An anti-inflammatory. SGTC_1345 1488-0192 31.4 µM -0.411820405500112 0.355922968658243 no 2209 0.340235531894418 3260 658348 SGTC_21 0849-0113 22.993 µM -0.411845638408213 0.35591359144318 no 2210 0.34022628389483 3148 1560156 SGTC_557 1315-0110 16.2 µM -0.412005219130173 0.355854289051411 no 2211 0.340167798908669 3099 6833801 SGTC_1487 3970-0795 2.82 µM -0.412412274944457 0.355703037308711 no 2212 0.340018633808494 3220 3765103 SGTC_822 1487-0950 154 µM -0.41458197160179 0.354897216129631 no 2213 0.339223974073909 3282 1958375 SGTC_1350 1495-0454 146 µM -0.415159461386295 0.354682846689375 no 2214 0.339012586487117 3283 1069057 SGTC_2654 protoveratrine a 100 µM -0.415621503538602 0.354511365585911 no 2215 0.338843494484893 3138 5702278 A heart drug and vasodilator. SGTC_1485 3909-9022 254 µM -0.41674463280046 0.354094653365134 no 2216 0.33843260211667 3220 714516 SGTC_807 1315-0151 48 µM -0.417194148998923 0.353927919260589 no 2217 0.338268202259594 3332 4011080 SGTC_1745 st081495 74 µM -0.417249365243222 0.353907440436682 no 2218 0.338248010357045 3204 13842402 YBL026W LSM2 SGTC_2444 5485484 36.41 µM -0.417372044780232 0.353861942066837 no 2219 0.338203149621774 3241 6790631 SGTC_483 fpl-64176 144 µM -0.417543075970129 0.353798514919738 no 2220 0.338140611770403 3213 3423 SGTC_1478 0453-0656 35.7 µM -0.417610572060248 0.353773485020414 no 2221 0.33811593293681 3215 5258496 SGTC_550 4123-0385 25.7 µM -0.417915948185782 0.353660248825338 no 2222 0.338004285880997 3136 5731123 SGTC_870 0573-2213 57.6 µM -0.418209505500771 0.353551407356111 no 2223 0.337896973273187 3216 3916321 SGTC_177 1327-0068 8.361 µM -0.41848129602504 0.353450646976019 no 2224 0.337797629462864 3246 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_2014 4013930 200 µM -0.420370284289038 0.352750630040051 no 2225 0.33710748633883 3248 64556 SGTC_2102 5377816 72.7585 µM -0.421200144040276 0.352443259896521 no 2226 0.33680446959715 3310 1379702 SGTC_1311 1190-0148 100 µM -0.422394705079374 0.35200097792914 no 2227 0.336368471033128 3283 1961333 SGTC_3156 9099931 49.47 µM -0.423068185350092 0.351751712450735 no 2228 0.336122756797811 3097 18111053 SGTC_629 3448-6466 76.7 µM -0.423169755132006 0.351714125427935 no 2229 0.336085705895558 3188 573744 SGTC_966 1300-0360 30.2 µM -0.42317274133607 0.351713020371977 no 2230 0.336084616603985 3138 70588 SGTC_62 0180-0423 3.232 µM -0.425655922341112 0.350794544469561 no 2231 0.335179292347318 3174 30102 YGL099W LSG1 SGTC_2845 9003024 42.97 µM -0.426114567170371 0.350624996658234 no 2232 0.335012182985908 3348 2990173 SGTC_2285 7945142 200 µM -0.426571314596444 0.350456179827007 no 2233 0.334845797405572 3254 2970608 SGTC_949 1165-0505 146 µM -0.42661376875208 0.350440489993521 no 2234 0.334830333700479 3150 6244267 SGTC_1948 st076329 66.6 µM -0.426734055458015 0.350396036876406 no 2235 0.334786521415285 3167 24208413 SGTC_3064 1327-0027 10 µM -0.427676698599155 0.350047744965097 no 2236 0.334443258386476 3156 16000455 YPR107C YTH1 SGTC_2058 5236698 133 µM -0.427960658186309 0.349942851037152 no 2237 0.33433988175012 3164 766665 SGTC_285 1486-1325 46 µM -0.429010421905911 0.349555170531399 no 2238 0.333957820135975 3269 22310230 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.432547409611512 0.348250108281694 no 2239 0.332671801342754 3281 1377 SGTC_931 2812-0076 566 µM -0.43351576255035 0.347893121948347 no 2240 0.332320058663001 3139 3450959 SGTC_522 1273-0010 11.6 µM -0.434490802683958 0.347533806538897 no 2241 0.331966036101978 3356 5705015 SGTC_106 0092-0003 11.579 µM -0.435824758114748 0.347042447891175 no 2242 0.331481939694693 3208 1072148 SGTC_1952 st077036 64.1 µM -0.436434244705031 0.346818030763466 no 2243 0.33126084879434 3230 2937007 SGTC_3297 9117502 71.43 µM -0.437829103245505 0.346304636616464 no 2244 0.330755086069809 3262 7453720 SGTC_2522 biochanin a 4.94 µM -0.440813226535735 0.345207243724694 no 2245 0.329674108679403 3295 5280373 A possible chelator. SGTC_1243 0416-0003 5.65 µM -0.44239085304154 0.344627606129045 no 2246 0.329103198446142 3181 2141977 SGTC_2519 cryptotanshinone 88.04 µM -0.443286235517523 0.344298794697629 no 2247 0.328779355253198 3316 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_653 0203-0016 55.2 µM -0.443296490831944 0.34429502931813 no 2248 0.328775646840645 3226 295302 SGTC_2202 7226349 200 µM -0.44336650980629 0.344269321302752 no 2249 0.328750327809694 3152 844334 SGTC_2012 4023501 200 µM -0.44517982562552 0.343603799106218 no 2250 0.328094902452162 3223 3477460 SGTC_1067 clotrimazole 1.36 µM -0.445223256154965 0.343587865189572 no 2251 0.328079210909269 3192 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1171 0368-0077 21.4 µM -0.448104717636388 0.342531328480829 no 2252 0.327038811740611 3159 3239779 SGTC_2134 5324836 1.464 µM -0.448771158937855 0.342287141441883 no 2253 0.32679837302756 3163 699272 SGTC_544 k015-0020 52.4 µM -0.448788663710751 0.342280728503798 no 2254 0.326792058623748 3233 3008304 SGTC_1804 st050076 49.1 µM -0.449846522034212 0.34189326269128 no 2255 0.326410555143344 3283 3895976 SGTC_144 4161-2749 112.381 µM -0.449853700601905 0.341890633938066 no 2256 0.326407966901597 3214 797501 YMR168C CEP3 SGTC_1779 st039427 55 µM -0.450900833462012 0.341507261637089 no 2257 0.326030511398987 3386 1124498 SGTC_1020 4335-0961 93.3 µM -0.451568085063502 0.341263055258142 no 2258 0.325790082989442 3134 669075 SGTC_1214 0358-0031 63.7 µM -0.451797147521106 0.34117923636356 no 2259 0.325707562420801 3386 4301366 SGTC_3235 9132602 49.47 µM -0.451816074342865 0.341172310981616 no 2260 0.325700744347555 3323 4912240 SGTC_1856 st057054 55.7 µM -0.452017384750722 0.34109865419907 no 2261 0.325628229224444 3382 1266018 SGTC_1611 st001856 99.4 µM -0.452278959667611 0.34100295648511 no 2262 0.325534015750086 3231 647478 SGTC_449 xestospongin c 11.1929 µM -0.452317952609857 0.340988691713954 no 2263 0.32551997231291 3289 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_2826 7992541 19.48 µM -0.452393583481299 0.340961024353072 no 2264 0.325492734310424 3266 2985066 SGTC_2204 7233102 200 µM -0.45245012676796 0.340940340190229 no 2265 0.325472371195352 3204 2172480 SGTC_2602 kawain 100 µM -0.45248339549061 0.340928170345044 no 2266 0.325460390267046 3276 5369129 SGTC_1662 st014054 52 µM -0.456512288479594 0.339455610609486 no 2267 0.324010818134839 3227 2838777 SGTC_1667 st014849 34.6 µM -0.457002759084434 0.339276510382701 no 2268 0.323834531180568 3254 5348460 SGTC_1762 st045503 25.4615 µM -0.457175480717398 0.33921344799951 no 2269 0.323772460268493 3274 4645554 SGTC_3042 9091578 49.47 µM -0.459165453730398 0.338487214338452 no 2270 0.323057678266252 3298 25236497 SGTC_691 1548-0686 185 µM -0.46031091433501 0.33806945453133 no 2271 0.322646534095001 3226 46495133 SGTC_2766 oltipraz 83.91 µM -0.460842291116879 0.337875724278346 no 2272 0.322455878736188 3314 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_2810 7959871 45.46 µM -0.46117442873938 0.337754654781323 no 2273 0.32233673310721 3262 2974535 SGTC_313 3474-0040 5.03 µM -0.461211063761669 0.337741301755062 no 2274 0.322323592374567 3177 1043375 YIL048W NEO1 SGTC_2956 9076196 2.52 µM -0.461672763194733 0.337573035359955 no 2275 0.322158002972681 3345 16423868 SGTC_1232 0279-0259 161 µM -0.463435849867225 0.33693077725821 no 2276 0.321525993447915 3244 1560000 SGTC_2291 7917025 104.35 µM -0.46412509037756 0.336679829454723 no 2277 0.321279063281217 3157 2964612 SGTC_1330 1469-0054 61.8 µM -0.465391371557694 0.336218974607761 no 2278 0.32082560603632 3327 7102664 SGTC_3082 9117008 49.47 µM -0.466149376338231 0.335943221336685 no 2279 0.320554291141498 3236 41448529 SGTC_1947 st076332 61.6 µM -0.466576996440744 0.335787697086915 no 2280 0.320401274093426 3328 24208416 SGTC_579 4491-1009 110 µM -0.467966627011502 0.335282486569599 no 2281 0.319904227811051 3366 1271041 SGTC_2061 5245884 80.95 µM -0.468253272925518 0.335178311334625 no 2282 0.319801739812288 3199 573863 SGTC_332 4112-0506 40.9 µM -0.46956607136085 0.334701365311068 no 2283 0.319332534884911 3232 2790355 SGTC_1834 st055981 52.8 µM -0.469781461909585 0.334623138318099 no 2284 0.319255580131756 3375 471719 YDL150W RPC53 SGTC_1983 st071813 46.9 µM -0.469851846844623 0.334597576998336 no 2285 0.319230434684121 3267 11838595 SGTC_1371 2421-0008 32.7 µM -0.470292604333729 0.33443752689743 no 2286 0.319072990292836 3219 2827552 SGTC_2675 theaflavin digallate 100 µM -0.470715139468503 0.334284122036628 no 2287 0.318922085803334 3303 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_785 1270-0111 65.3 µM -0.470773353222176 0.334262989222275 no 2288 0.318901297654885 3205 6741994 SGTC_1888 azatryptophan 97.5 µM -0.471280708751961 0.334078830763305 no 2289 0.318720144972186 3303 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_1862 st057513 3.81 µM -0.472196175946317 0.333746638179649 no 2290 0.318393384503589 3192 5393163 SGTC_650 1328-0195 38 µM -0.472648896152644 0.333582409204553 no 2291 0.318231845887586 3320 2780821 SGTC_2582 agaric acid 100 µM -0.473003649257757 0.333453741096741 no 2292 0.318105287825763 3324 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_1935 st074532 41.6 µM -0.473132386331565 0.333407053310155 no 2293 0.318059366164512 3321 2829742 SGTC_2686 alizarin 95.37 µM -0.473548628244371 0.333256116683871 no 2294 0.317910908110217 3247 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_206 4546-0025 72.014 µM -0.47419318590691 0.333022442039719 no 2295 0.317681076037851 3327 6620745 YIL048W NEO1 SGTC_769 0302-0231 76 µM -0.474514289711873 0.332906054889886 no 2296 0.317566605190765 3329 571869 YER009W NTF2 SGTC_137 0438-0332 85.389 µM -0.474702839419681 0.332837720742512 no 2297 0.317499396908031 3342 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_1632 st005650 90 µM -0.474722597814356 0.332830560230417 no 2298 0.317492354403727 3294 2759605 SGTC_2241 6772625 37.8075 µM -0.474793954883503 0.332804700683963 no 2299 0.317466921082535 3316 2285411 SGTC_1713 st033146 12.748 µM -0.477102031500155 0.331968691486209 no 2300 0.316644734075056 3381 674619 SGTC_2427 5545055 42.75 µM -0.477839160101252 0.331701871784078 no 2301 0.316382343343659 3247 5372858 SGTC_616 4092-0450 108 µM -0.478364034752974 0.331511934027193 no 2302 0.316195563547064 3302 787165 SGTC_2921 7974240 10.71 µM -0.478884065581013 0.331323791837924 no 2303 0.316010553697987 3336 2979074 YDR527W RBA50 SGTC_3017 9080681 49.47 µM -0.481495875114745 0.330379508622982 no 2304 0.315082055340008 3300 16451914 SGTC_695 3505-6186 243 µM -0.482624961119787 0.329971628414493 no 2305 0.314681026220466 3335 1819379 SGTC_1876 myriocin 605 nM -0.482991811283572 0.329839147943534 no 2306 0.31455077526904 3389 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_2605 digitonin 300 nM -0.484350125158779 0.329348806448465 no 2307 0.314068703974518 3434 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_1813 st051246 8.6015 µM -0.485006841668625 0.329111841675847 no 2308 0.31383574618637 3311 5291959 SGTC_478 N-arachidonylglycine 10 µM -0.486254188184073 0.328661947380274 no 2309 0.313393477889203 3290 5283389 SGTC_372 0155-0182 15.9 µM -0.488211250148094 0.327956572571857 no 2310 0.312700108342534 3272 771486 SGTC_614 0462-0418 107 µM -0.488268298021239 0.327936020257032 no 2311 0.312679906713968 3257 5188303 SGTC_2326 6164455 177.58 µM -0.488855319571822 0.327724567596965 no 2312 0.312472065027406 3290 2888790 SGTC_1711 st032263 62.8 µM -0.488866439374031 0.32772056263501 no 2313 0.31246812850975 3299 3958979 SGTC_2871 9038510 12.99 µM -0.491575240749667 0.326745538967746 no 2314 0.311509825024994 3417 4945164 SGTC_158 k038-0087 26.446 µM -0.492636311352676 0.32636393208073 no 2315 0.311134793134351 3210 X158 SGTC_1895 st058434 18.3 µM -0.495172854949329 0.325452418146119 no 2316 0.310239055062193 3402 5393175 SGTC_2032 5185112 25.99 µM -0.495482836853451 0.325341096707452 no 2317 0.310129667132909 3280 5718189 SGTC_2839 9003951 25.97 µM -0.495730139425288 0.325252295993921 no 2318 0.310042409840041 3369 2990634 SGTC_3051 9093778 49.47 µM -0.496549715644515 0.324958075817179 no 2319 0.30975331019168 3321 17217378 SGTC_1358 1509-0022 2.48 µM -0.496709196663551 0.324900836306063 no 2320 0.309697068070134 3338 3258434 SGTC_1751 st044839 27.194 µM -0.49766857428533 0.324556592271749 no 2321 0.309358830740564 3375 5291326 SGTC_1794 st048918 76.9 µM -0.49767382919462 0.324554707116698 no 2322 0.309356978518755 3326 672303 SGTC_2043 5101342 149 µM -0.498806448528162 0.324148494306777 no 2323 0.308957872125058 3286 678451 SGTC_706 4262-0057 46.9 µM -0.498955992358424 0.32409487618728 no 2324 0.308905193500934 3290 883298 SGTC_1028 k015-0029 4.8 µM -0.500935973582262 0.323385309102791 no 2325 0.308208092023378 3315 4588309 SGTC_474 dl-dihydrosphingosine 5 µM -0.501032124847674 0.323350867637069 no 2326 0.308174257164781 3405 3058739 A sphingolipid protein kinase C inhibitor. SGTC_523 1934-0222 13.7 µM -0.501234710736741 0.323278306152779 no 2327 0.308102974151619 3265 1361595 SGTC_3342 9147791 14.508 µM -0.501419182855329 0.323212238440978 no 2328 0.308038071047927 3322 1838168 SGTC_1728 st035614 33.7865 µM -0.503178206511105 0.322582533752976 no 2329 0.307419492875537 3320 15945546 SGTC_308 4092-1169 104 µM -0.50440594386339 0.322143322992381 no 2330 0.306988071019487 3303 2268590 YDL196W YDL196W SGTC_675 1309-0189 238 µM -0.505491253983237 0.321755270838747 no 2331 0.306606919899706 3313 4246530 SGTC_2139 5578692 56.4705 µM -0.507712785636461 0.320961569575508 no 2332 0.305827390283555 3343 650991 YMR113W FOL3 SGTC_2458 5808907 16.39 µM -0.508283261684159 0.320757883598839 no 2333 0.305627353424592 3437 2731747 SGTC_66 0109-0187 42.4 µM -0.508316772519569 0.32074592037871 no 2334 0.305615604686427 3409 759417 SGTC_2576 guaiol 23.12 µM -0.511279667118127 0.319688917171817 no 2335 0.30457762026224 3320 227829 SGTC_3011 9081274 71.4286 µM -0.512618895499216 0.319211631200111 no 2336 0.304108966489957 3305 6625322 SGTC_959 1222-0044 107 µM -0.512958516533323 0.31909064164637 no 2337 0.303990169540913 3392 6083612 SGTC_2305 7443522 69.23 µM -0.513619440385525 0.318855243625795 no 2338 0.303759042551314 3353 5415886 SGTC_894 0960-0238 55.9 µM -0.513788866208627 0.318794911818564 no 2339 0.30369980647837 3408 6741907 YDL195W SEC31 SGTC_2077 5212015 200 µM -0.514280485493272 0.318619875492298 no 2340 0.303527951625713 3315 780900 SGTC_728 3030-5151 22.5 µM -0.51699448398737 0.317654311562847 no 2341 0.302580004696179 3355 3125388 SGTC_1474 0330-0125 5.35 µM -0.517030841683958 0.317641384918237 no 2342 0.302567314670095 3407 X1474 SGTC_143 4032-1194 15.74 µM -0.52005730588733 0.316566134136695 no 2343 0.301511817171856 3359 1806963 SGTC_244 nsc-207895 1.295 µM -0.520882039533756 0.316273388508973 no 2344 0.30122447389506 3296 42640 SGTC_2879 9041815 71.43 µM -0.521507739973822 0.316051368050235 no 2345 0.301006557577502 3361 4942971 SGTC_1396 3511-0007 98.6 µM -0.523044954851106 0.315506192057254 no 2346 0.300471484869497 3373 X1396 SGTC_2971 9092186 9.93 µM -0.523534696962156 0.31533258838653 no 2347 0.30030110605354 3267 25236400 SGTC_2113 5491891 107.031 µM -0.523824469038152 0.315229889240078 no 2348 0.30020031637242 3355 789979 SGTC_775 4577-0580 57.3 µM -0.523889289203405 0.315206918049829 no 2349 0.300177772457102 3491 2006902 SGTC_2939 9044578 71.43 µM -0.524354721959673 0.315041997397333 no 2350 0.300015921296156 3330 2653634 SGTC_1224 0823-0416 294 µM -0.525040011904474 0.314799240027106 no 2351 0.299777688146403 3429 3598164 SGTC_1347 1493-0251 600 nM -0.529116802778888 0.313356732707725 no 2352 0.298362212994021 3430 3986378 SGTC_816 0325-0417 81.3 µM -0.529904375797075 0.313078390440946 no 2353 0.298089116059403 3395 68101 SGTC_1969 st069479 40.1 µM -0.530490633573522 0.312871265674419 no 2354 0.29788590069117 3425 3895485 SGTC_1767 st044992 70.3 µM -0.530999053588784 0.312691688787935 no 2355 0.29770971749831 3370 9600693 SGTC_1118 chelidonine 707.474 nM -0.531297418304037 0.312586325341478 no 2356 0.297606347077579 3434 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_711 k292-0785 179 µM -0.531668093920816 0.312455447615911 no 2357 0.297477946892266 3385 4146315 SGTC_1447 4239-0816 81.9 µM -0.53212979535065 0.312292463678707 no 2358 0.297318051205777 3351 1341554 SGTC_2502 avocadyne acetate 18.59 µM -0.533866516731136 0.311679717566458 no 2359 0.29671694465359 3352 3952079 SGTC_2896 9052656 71.43 µM -0.534008172411744 0.31162976189023 no 2360 0.296667939951681 3379 6469436 SGTC_2034 5197015 53.07 µM -0.534981972447015 0.311286439675703 no 2361 0.296331161625766 3445 780676 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.53626675354063 0.310833729287689 no 2362 0.295887102235083 3419 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2338 7999974 200 µM -0.536836646984261 0.310633011036944 no 2363 0.295690227631509 3430 315925 SGTC_3095 9117207 49.47 µM -0.537982758610065 0.310229517620951 no 2364 0.295294475877531 3395 17015229 SGTC_3030 9087619 49.47 µM -0.53870808765665 0.309974280426513 no 2365 0.295044146148952 3367 25236973 SGTC_119 0121-0043 24.815 µM -0.539000849321124 0.309871285984419 no 2366 0.294943134258079 3473 1092378 SGTC_2623 humulene 100 µM -0.539535778952281 0.309683134660282 no 2367 0.29475860804887 3398 6187145 An anti-inflammatory. SGTC_1970 st070122 35.8 µM -0.539835258106196 0.309577820329635 no 2368 0.294655324712838 3494 102928 SGTC_2008 4012253 172 µM -0.54022738247821 0.309439950175472 no 2369 0.294520115458052 3355 603940 SGTC_303 1348-1668 34.2 µM -0.54261971755325 0.30859939137687 no 2370 0.293695830119372 3402 5380509 SGTC_684 1140-0066 328 µM -0.542716745093033 0.308565321384102 no 2371 0.293662421567363 3420 6813534 SGTC_1498 4478-3555 97.6 µM -0.543703910893521 0.30821878432988 no 2372 0.293322620375232 3426 3437919 SGTC_1080 nisoldipine 24.4 µM -0.543825088316861 0.308176257684361 no 2373 0.293280921367586 3326 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_2315 7733312 200 µM -0.544911258077275 0.307795186559514 no 2374 0.292907276466659 3334 726316 SGTC_214 4373-3496 70 µM -0.546668521369931 0.307179108339999 no 2375 0.292303242154164 3507 3779166 SGTC_250 brefeldin a 552.239 µM -0.547389631632057 0.306926451863787 no 2376 0.292055538496876 3367 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_2936 9038235 15.59 µM -0.548220719368618 0.30663537612508 no 2377 0.291770178491389 3402 4749415 SGTC_2778 tioconazole 65.09 nM -0.550113186377059 0.305973023658865 no 2378 0.291120871424134 3411 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_1223 0764-0573 147 µM -0.551360135768308 0.305536944927545 no 2379 0.290693411154647 3434 1609797 SGTC_2710 st078562 53.7235 µM -0.552685176346233 0.305073858567862 no 2380 0.290239502819663 3392 17250908 SGTC_2434 5670830 169.91 µM -0.55376033778858 0.304698331271418 no 2381 0.289871437716933 3423 1549830 SGTC_3054 9094397 49.47 µM -0.554836287609648 0.304322734518156 no 2382 0.289503322039881 3383 2598354 SGTC_3012 9080433 71.4286 µM -0.555769207831051 0.303997234068896 no 2383 0.28918431902286 3473 17688859 SGTC_422 cantharidin 155 µM -0.556314636855267 0.303807003130592 no 2384 0.28899789144636 3421 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1072 oxiconazole 14.9 nM -0.557259453134052 0.30347760243105 no 2385 0.288675087220038 3468 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_1094 duloxetine 25.4 µM -0.558587866679603 0.303014734450643 no 2386 0.288221511285174 3406 60834 A selective serotonin reuptake inhibitor. SGTC_3168 9103419 49.47 µM -0.558908456925262 0.302903076390064 no 2387 0.28811209874348 3417 16649256 SGTC_1238 0333-0287 48.8 µM -0.559235260089309 0.302789273399374 no 2388 0.288000586004302 3411 7226 SGTC_1321 1326-2144 215 µM -0.559778314837454 0.30260020726354 no 2389 0.287815328332619 3441 3513030 SGTC_2111 5486399 200 µM -0.560130534575762 0.302477609200164 no 2390 0.287695202208908 3452 689674 SGTC_3244 9134489 49.47 µM -0.562811727824562 0.301545090077883 no 2391 0.286781546730046 3435 16584271 SGTC_2557 derrustone 83.84 µM -0.563634422757758 0.30125921628824 no 2392 0.286501477510109 3481 629853 An antioxidant. SGTC_1348 1493-0373 93.8 µM -0.563723987210346 0.30122810139241 no 2393 0.286470995007006 3414 3010129 SGTC_1899 st063254 59.6 µM -0.564177600533417 0.301070537321412 no 2394 0.286316635192368 3398 3093813 SGTC_1943 st076331 65.2 µM -0.565037475009275 0.300771959102812 no 2395 0.286024137426015 3514 24208415 SGTC_3240 9133527 49.47 µM -0.565183909541723 0.300721125274212 no 2396 0.28597433992163 3431 17617455 SGTC_2743 auranofin 4.32 µM -0.566982550708157 0.300097054837083 no 2397 0.28536301841712 3387 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_1898 st060199 18.6 µM -0.56838416687788 0.299611145748461 no 2398 0.284887069529209 3460 688866 SGTC_1495 4469-0029 237 µM -0.568439957920292 0.299591811616987 no 2399 0.284868132321349 3462 793680 SGTC_1001 4048-4355 44.4 µM -0.569846833040798 0.299104452461169 no 2400 0.284390793953462 3450 21824233 SGTC_2188 6126565 140.678 µM -0.570400311009655 0.298912819456431 no 2401 0.284203109340679 3456 874518 SGTC_1319 1306-0155 43.7 µM -0.573482735235196 0.29784660052381 no 2402 0.28315894277638 3471 3122360 SGTC_2626 ethyl orsellinate 100 µM -0.573517302360362 0.297834653500498 no 2403 0.283147243658762 3417 75653 A natural product. SGTC_652 0437-0092 114 µM -0.574870367634619 0.297367181488832 no 2404 0.282689485957908 3483 3091274 SGTC_228 caffeine 993.056 µM -0.575404884606843 0.297182603034649 no 2405 0.28250875069987 3500 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_2642 cholecalciferol 100 µM -0.577263643240602 0.296541147892154 no 2406 0.28188068491029 3462 9821465 A vitamin D precursor, similar to steriods. SGTC_1051 3253-3903 78 µM -0.577997484726557 0.296288074946989 no 2407 0.281632908699304 3405 5509239 SGTC_52 0329-0193 875 nM -0.579778671870096 0.295674226183461 no 2408 0.281031941094539 3557 3739292 SGTC_1624 st003710 6.25 µM -0.580275139630236 0.295503233210912 no 2409 0.280864544736563 3499 24207033 SGTC_1326 1431-2094 10.8 µM -0.580424268313775 0.295451879328956 no 2410 0.280814271736353 3436 616278 SGTC_263 alizarin 107.927 µM -0.581282168085169 0.295156533138614 no 2411 0.280525148363692 3487 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_1351 1496-0003 46.5 µM -0.58206142479895 0.294888379001313 no 2412 0.280262653649617 3494 3891978 SGTC_1400 3771-8998 51.5 µM -0.582091137140084 0.294878156753469 no 2413 0.280252647323004 3449 670767 SGTC_1942 st076330 65.2 µM -0.583708254214283 0.29432204954333 no 2414 0.279708306465843 3558 24208414 SGTC_2953 9074162 66.49 µM -0.584002335780414 0.294220970481717 no 2415 0.279609370272926 3474 16451992 SGTC_471 1-acyl-paf 4 µM -0.584433044801653 0.294072960014562 no 2416 0.279464499946143 3426 16759367 SGTC_1403 3909-7815 62.9 µM -0.586643887441697 0.293313760019708 no 2417 0.278721450425387 3436 6615483 SGTC_2922 7999257 32.47 µM -0.586974096940871 0.293200444593944 no 2418 0.278610551814754 3500 2988377 SGTC_168 3970-0862 530.542 µM -0.588428662068378 0.292701534576257 no 2419 0.278122301991946 3481 3135186 SGTC_1459 k035-0031 35.7 µM -0.58900534121207 0.292503845144398 no 2420 0.277928845306655 3437 3877128 YMR208W ERG12 SGTC_1106 tegaserod maleate 11.7 µM -0.589506802432114 0.292331991373881 no 2421 0.277760675137676 3459 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_2685 mycophenolic acid 18.85 µM -0.59027740929173 0.292067991337633 no 2422 0.277502341108003 3441 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_3205 9113483 49.47 µM -0.591024399798177 0.291812187938222 no 2423 0.277252036231149 3510 17018033 SGTC_1730 st033808 45.1 µM -0.591453867766771 0.291665165916586 no 2424 0.277108178222016 3423 1045166 SGTC_379 3970-0972 5.9 µM -0.591723811885928 0.29157277220632 no 2425 0.277017774290325 3479 2898042 YBL034C STU1 SGTC_2388 9080168 200 µM -0.592688981727508 0.291242535432992 no 2426 0.276694658313267 3449 15943073 SGTC_877 0771-0151 33.1 µM -0.594954897194998 0.290467930189598 no 2427 0.275936810026236 3465 6166523 SGTC_731 3966-0296 387 µM -0.597253012996566 0.289683303606998 no 2428 0.275169235013032 3518 660956 SGTC_2537 larixol 68.93 µM -0.600687703891973 0.288512483539735 no 2429 0.274024005183557 3532 6708759 SGTC_2292 7671323 168.05 µM -0.601826378112677 0.288124824160456 no 2430 0.273644857301936 3513 937504 SGTC_832 4083-0019 164 µM -0.601869064317878 0.288110296507336 no 2431 0.273630648992972 3581 1990758 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.602045101947836 0.288050388213582 no 2432 0.273572057877044 3648 16725076 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.602513478116789 0.287891021289105 no 2433 0.273416197117407 3540 5024745 SGTC_804 1595-0054 20.9 µM -0.603191276533184 0.287660471332866 no 2434 0.273190725139898 3463 761523 Stimulates phospholipase C. SGTC_1957 st077035 62.4 µM -0.604180601347764 0.287324113845768 no 2435 0.272861788289119 3578 705593 SGTC_2914 7968218 45.32 µM -0.604311139503417 0.28727974648175 no 2436 0.272818400827574 3493 2977111 SGTC_1056 3448-1962 115 µM -0.604691300879798 0.287150555543136 no 2437 0.272692064649029 3499 715507 SGTC_1470 k295-0292 231 µM -0.605278479649631 0.286951067569816 no 2438 0.272496989001244 3538 5045612 SGTC_2742 clothiapine 36.27 µM -0.606902155515082 0.286399782375015 no 2439 0.271957923778072 3487 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_1546 5-methoxyflavanone 78.7 µM -0.607408555828199 0.286227947631259 no 2440 0.271789905942777 3564 147795 SGTC_752 1896-0090 130 µM -0.607610121051713 0.286159564954868 no 2441 0.271723043281328 3533 772567 SGTC_1452 4194-0072 190 µM -0.60797531576897 0.286035689384368 no 2442 0.271601922752929 3564 1343545 SGTC_580 1123-0028 41 µM -0.608472408244859 0.28586711450579 no 2443 0.271437100208948 3587 1677248 YPR107C YTH1 SGTC_3199 9111318 49.47 µM -0.608998467738425 0.28568876774494 no 2444 0.271262727266175 3482 8548020 SGTC_1944 st076371 56.9 µM -0.609561551459362 0.285497927560832 no 2445 0.271076143793137 3421 24208455 SGTC_592 k241-0073 46.5 µM -0.611546097801738 0.28482580996535 no 2446 0.270419055103245 3551 4230158 SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.612338607072469 0.284557617449348 no 2447 0.270156875721446 3531 140250 A respiratory chain inhibitor. SGTC_2661 dactinomycin 12.96 µM -0.612706076339702 0.284433303365499 no 2448 0.270035352016971 3546 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_420 mitomycin C 81.9 mM -0.613348205395884 0.284216134756128 no 2449 0.269823062789815 3528 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.613580162570341 0.284137706131996 no 2450 0.269746397805626 3521 6312947 SGTC_1703 st026983 48.3 µM -0.61380108222771 0.284063019102528 no 2451 0.269673391014231 3561 1104023 SGTC_1640 st009078 66.4 µM -0.615548978798908 0.283472433330509 no 2452 0.269096116984279 3552 690618 SGTC_3287 9117173 37.0625 µM -0.617246635103397 0.282899386908049 no 2453 0.268536029945216 3492 2789709 SGTC_797 k781-0471 270 µM -0.617337613429424 0.282868692749534 no 2454 0.268506031127067 3490 23738129 SGTC_896 0964-0007 44.5 µM -0.619264405889793 0.282219009733538 no 2455 0.267871094455764 3536 6756758 SGTC_783 0848-0141 92.7 µM -0.620235328578247 0.281891902773515 no 2456 0.267551432727271 3547 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_3305 9127027 53.8275 µM -0.620574219068651 0.281777772505263 no 2457 0.267439903415722 3478 41905295 SGTC_3141 9094609 49.47 µM -0.621848334303889 0.281348880143217 no 2458 0.267020800302322 3465 25236309 YDL196W YDL196W SGTC_2644 guaiazulene 100 µM -0.623426535285679 0.280818063775239 no 2459 0.266502132516498 3551 3515 A coloring agent. SGTC_1852 st056254 31.4 µM -0.626052299491454 0.279935981666043 no 2460 0.265640319024648 3500 442583 SGTC_1131 3454-3128 32.3 µM -0.626225031659023 0.279878002278766 no 2461 0.265583675431695 3543 710982 SGTC_3356 9151811 4.48 µM -0.629304949044943 0.278845174200628 no 2462 0.264574715974259 3519 1859254 YPR165W RHO1 SGTC_1449 4112-4002 201 µM -0.629694800688455 0.278714572625385 no 2463 0.264447142472581 3543 2059539 SGTC_2417 cerulenin 830 nM -0.629800282743259 0.278679240911503 no 2464 0.264412630326404 3625 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_16 erodoxin 22.806 µM -0.630892995082939 0.278313360097291 no 2465 0.264055246172869 3597 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_2860 9025725 38.96 µM -0.631210462778018 0.278207103996767 no 2466 0.263951460868184 3478 40546248 SGTC_1691 st019933 84.6 µM -0.631229121873476 0.278200859432875 no 2467 0.263945361556214 3550 6176082 SGTC_1567 st069303 68.4 µM -0.632489788215041 0.277779115717395 no 2468 0.263533439583738 3584 5581319 SGTC_660 4031-1742 102 µM -0.632634630898072 0.277730680003011 no 2469 0.263486133344215 3514 6738706 SGTC_2634 4'-methoxyflavone 100 µM -0.63364745780972 0.277392103746013 no 2470 0.263155460906003 3524 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.634160114790167 0.277220805435556 no 2471 0.262988167127016 3570 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_1726 st035556 14.5795 µM -0.634229970628098 0.277197467934081 no 2472 0.262965375495019 3612 5919439 SGTC_1777 st045864 34.765 µM -0.63657660522068 0.276414061055924 no 2473 0.262200333939501 3579 4691462 SGTC_1336 1486-0901 104 µM -0.636577494556028 0.276413764363751 no 2474 0.262200044217838 3530 5006114 SGTC_3117 9124945 49.47 µM -0.637957136702606 0.275953688536371 no 2475 0.261750791293797 3505 17592065 SGTC_1790 st045711 43.5 µM -0.640441924786467 0.275126024334367 no 2476 0.26094266693881 3610 585119 SGTC_3111 9122088 49.47 µM -0.640928157552503 0.274964206991123 no 2477 0.260784680333692 3501 16876704 SGTC_1581 himbacine 57.9 µM -0.641234150979761 0.274862397004833 no 2478 0.26068528227696 3572 5281825 An alkaloid muscarinic receptor antagonist. SGTC_571 k831-0106 44.2 µM -0.643156982208167 0.274223059049589 no 2479 0.260061121631179 3560 4783639 SGTC_526 4469-0568 170 µM -0.643279860870459 0.274182227093624 no 2480 0.260021260811419 3595 2901964 SGTC_2348 9022543 33.42 µM -0.644628866483003 0.273734156927363 no 2481 0.259583861808846 3596 3162678 YDL140C RPO21 SGTC_1244 0416-0015 52.5 µM -0.644744489071125 0.273695769918453 no 2482 0.259546390245058 3596 96201 SGTC_2361 9034121 116 µM -0.644876051223156 0.273652094170842 no 2483 0.25950375630278 3561 6496917 SGTC_1430 4049-0248 69.1 µM -0.645298687203254 0.273511811634988 no 2484 0.259366821647006 3626 22774488 SGTC_742 0kpi-0133 140 µM -0.645788317449702 0.273349336690039 no 2485 0.259208227443375 3597 2728852 SGTC_1241 0364-0022 50.8 µM -0.645855792401864 0.273326950094895 no 2486 0.259186375827907 3568 4563895 SGTC_1806 st050005 60.3 µM -0.647673273756233 0.272724294562545 no 2487 0.258598146928695 3548 5194765 SGTC_1176 0848-0131 83.3 µM -0.64788399082817 0.272654465925648 no 2488 0.258529992970991 3632 6769040 SGTC_3086 9117350 49.47 µM -0.648724885131556 0.272375893919637 no 2489 0.258258108265394 3534 2679265 SGTC_18 0111-0177 500 nM -0.652664168452029 0.271072771104361 no 2490 0.25698640364817 3664 721752 SGTC_466 geldanamycin 89.2 µM -0.655404686324366 0.27016804005206 no 2491 0.256103617522799 3508 5288382 HSP90 inhibitor. SGTC_2987 9018338 71.43 µM -0.656385353755694 0.269844658230368 no 2492 0.255788105844175 3655 5055682 SGTC_1492 4158-0558 28.5 µM -0.659384022102542 0.268857030547726 no 2493 0.254824599851332 3594 3967268 SGTC_1021 4476-0760 85.3 µM -0.659394595083311 0.268853551493229 no 2494 0.2548212059975 3575 746768 SGTC_3269 9137823 49.47 µM -0.659813569799199 0.268715705462777 no 2495 0.254686737054671 3553 17682936 SGTC_1065 prochlorperazine maleate 2.48 µM -0.659893552147564 0.268689394667587 no 2496 0.254661071133935 3648 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_3351 9150312 21.596 µM -0.65998215210449 0.268660250556368 no 2497 0.254632641448708 3589 4904905 SGTC_528 3492-0019 172 µM -0.660033831818548 0.268643251740592 no 2498 0.254616059386545 3644 2869262 SGTC_1530 rhein 70.4 µM -0.661232064395821 0.268249273165627 no 2499 0.254231750590878 3644 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_958 1222-0007 33 µM -0.661824930004931 0.268054446653841 no 2500 0.254041713507888 3680 7312461 SGTC_2442 5158906 48.48 µM -0.66308762075621 0.267639740869914 no 2501 0.25363721926207 3622 1893835 SGTC_3114 9122766 49.47 µM -0.666305476065617 0.26658436423718 no 2502 0.252607933054233 3568 17176985 SGTC_756 0508-1999 28.3 µM -0.667577265276631 0.266167829943142 no 2503 0.252201736953802 3599 6753853 SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.668860621185307 0.265747841629269 no 2504 0.25179219601113 3631 16486 A toxic proline analog. SGTC_1797 st048695 56.8 µM -0.669400584209077 0.265571234948963 no 2505 0.251619989527837 3606 592262 YIL048W NEO1 SGTC_1300 1094-0077 113 µM -0.671883474627067 0.264759918454258 no 2506 0.250828940766321 3595 5532636 SGTC_668 1682-0499 62.6 µM -0.672664407888981 0.264504999204903 no 2507 0.250580407918568 3649 682214 SGTC_1998 st075797 76.8 µM -0.673586032789236 0.264204314881454 no 2508 0.250287267723983 3634 24208315 SGTC_1242 0402-0103 60.1 µM -0.674490759476595 0.263909313098302 no 2509 0.249999679274407 3602 432868 SGTC_2653 dihydrofissinolide 100 µM -0.677743270508235 0.26285016426152 no 2510 0.248967242878769 3662 6857746 SGTC_237 nikkomycin 200 µM -0.679440413524146 0.26229837029912 no 2511 0.248429425264671 3681 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_1932 st074806 40.9 µM -0.679804014490584 0.262180229540703 no 2512 0.2483142822102 3736 17251235 SGTC_3236 9132701 49.47 µM -0.682017265255996 0.261461691497183 no 2513 0.247614016845315 3614 24282524 SGTC_200 k038-0079 37.545 µM -0.682751685153471 0.261223483656143 no 2514 0.247381882076926 3614 3436683 SGTC_1006 4099-6547 255 µM -0.683017436573789 0.261137315120707 no 2515 0.247297912280716 3654 3146833 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.684706944051519 0.260589842852776 no 2516 0.246764433130973 3674 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_1078 idebenone 36.1 µM -0.684787902429076 0.260563623738528 no 2517 0.24673888518004 3663 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_1704 st028805 70.8 µM -0.685075069097945 0.260470633128812 no 2518 0.24664827571576 3656 2876101 SGTC_1153 4055-0057 267 µM -0.688221640595928 0.259452827816303 no 2519 0.245656609085216 3676 882706 SGTC_3060 1327-0027 12.5 µM -0.688948354372549 0.259218053788131 no 2520 0.245427884292783 3588 16000455 YPR107C YTH1 SGTC_2917 7979103 53.79 µM -0.690129881804585 0.258836581010628 no 2521 0.245056256553298 3666 2980565 SGTC_2391 6285546 200 µM -0.691600522026561 0.258362170217889 no 2522 0.244594116881087 3653 846083 SGTC_527 4476-4215 268 µM -0.693408345527828 0.257779606116165 no 2523 0.244026663206278 3652 4418754 SGTC_3327 9140648 26.9345 µM -0.697306098653389 0.25652589390829 no 2524 0.242805626115359 3653 8029710 SGTC_139 0099-0334 718.624 µM -0.697578562837076 0.256438374735553 no 2525 0.242720395923782 3715 97690 SGTC_147 4466-0538 29.23 µM -0.697936332953733 0.25632347777726 no 2526 0.24260850557266 3739 6742687 YHR072W ERG7 SGTC_2191 5911152 200 µM -0.698065474965684 0.256282010741963 no 2527 0.242568124083043 3678 2875902 SGTC_826 1683-5028 118 µM -0.698723107384764 0.256070901595752 no 2528 0.242362545099917 3706 722377 SGTC_499 genistein 192 µM -0.700043891442653 0.255647185737391 no 2529 0.241949947158006 3673 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_1302 1159-0335 255 µM -0.702584714679993 0.254833104461081 no 2530 0.24115729548657 3678 649284 SGTC_2610 ononetin 44.17 µM -0.703774884252378 0.254452240633892 no 2531 0.240786488529617 3685 259632 SGTC_1562 morin hydrate 59.1 µM -0.704134559757559 0.25433720030188 no 2532 0.240674489793201 3714 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_2907 7721985 69.9 µM -0.705109290486319 0.25402557487889 no 2533 0.240371112666123 3651 3267881 SGTC_1676 st018489 23.4 µM -0.706942206655955 0.253440127004626 no 2534 0.239801196809146 3721 3696235 SGTC_3165 9101544 49.47 µM -0.7072836441621 0.25333114757274 no 2535 0.239695113811554 3677 5002184 SGTC_2919 7978188 46.38 µM -0.711424651327778 0.252011391700239 no 2536 0.238410563771885 3671 2980291 SGTC_3101 9120531 49.47 µM -0.712281004796635 0.25173892174966 no 2537 0.238145392096168 3739 24824904 SGTC_376 3970-0862 59.1 µM -0.713046822357244 0.251495389851949 no 2538 0.237908392011648 3691 3135186 SGTC_2101 5377231 179.231 µM -0.714640558152341 0.250988977279222 no 2539 0.237415588221213 3707 2844213 SGTC_2455 5377712 9.75 µM -0.716652868992403 0.250350333300621 no 2540 0.236794156969873 3669 2243908 SGTC_1675 st018485 24.5 µM -0.717777406754494 0.249993816064225 no 2541 0.236447273113426 3746 3323024 SGTC_3337 9144342 33.5465 µM -0.717821336888248 0.249979894167337 no 2542 0.236433727754142 3724 17682949 SGTC_3332 9141069 11.198 µM -0.720243651645431 0.249212875710823 no 2543 0.235687495892784 3662 17332883 SGTC_2997 9067075 71.4286 µM -0.720328171352048 0.249186135422895 no 2544 0.23566148175136 3730 27209819 SGTC_1339 1486-1321 22.7 µM -0.721584185892965 0.248788938283605 no 2545 0.23527508238843 3746 3469382 SGTC_791 1348-1292 225 µM -0.722342598611216 0.248549264127254 no 2546 0.235041934350883 3710 5437054 SGTC_2775 cyproheptadine 69.59 µM -0.723148589423222 0.248294689200433 no 2547 0.234794300016493 3706 2913 A selective serotonin reuptake inhibitor. SGTC_2295 7971645 200 µM -0.725692909608442 0.24749196999342 no 2548 0.234013524714476 3741 2978226 YKL099C UTP11 SGTC_961 1252-1571 372 µM -0.726424961125581 0.247261268861497 no 2549 0.233789146842845 3718 6813498 SGTC_714 4296-0578 26.1 µM -0.728887346677103 0.246486109140364 no 2550 0.233035287724996 3741 1589775 SGTC_599 1935-0052 86.5 µM -0.729696201790241 0.246231765703654 no 2551 0.232787951655944 3711 9557311 SGTC_707 0865-0008 204 µM -0.730250106296351 0.246057672366332 no 2552 0.232618659939739 3711 723043 SGTC_2110 5483698 200 µM -0.730883476904479 0.245858683615442 no 2553 0.232425164630561 3735 2848765 YHR062C RPP1 SGTC_2705 st078069 42.8 µM -0.731192214456126 0.245761717541371 no 2554 0.232330877484852 3733 1530061 SGTC_1820 st053765 18.6 µM -0.731231799152714 0.245749286549182 no 2555 0.232318790024737 3714 3690829 SGTC_2104 5389443 200 µM -0.731639479141672 0.245621280284577 no 2556 0.232194322486815 3762 2244536 SGTC_520 3584-0023 682 µM -0.731987555785431 0.245512017048839 no 2557 0.232088081640847 3749 1340790 SGTC_703 3875-0075 71.8 µM -0.732227355098052 0.245436757876807 no 2558 0.232014905225185 3772 2850814 SGTC_1397 3532-0190 20.1 µM -0.732305480632561 0.24541224145556 no 2559 0.231991067453623 3648 5322280 SGTC_503 tyrphostin 8 294 µM -0.732948845353482 0.245210398481707 no 2560 0.231794814980229 3689 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_1011 4112-3381 17.4 µM -0.733162566445347 0.24514336746661 no 2561 0.231729641803275 3778 2877139 SGTC_1545 lovastatin 49.4 µM -0.735336784595831 0.244462010838101 no 2562 0.231067205444598 3795 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_1646 st011709 75.6 µM -0.735767593094231 0.244327125260443 no 2563 0.230936073159435 3692 5757843 SGTC_690 glyoxal 20.3 µM -0.735851523251137 0.244300851507521 no 2564 0.230910530790472 3629 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_125 0133-0007 11.75 µM -0.736837881012327 0.243992193204642 no 2565 0.230610471881742 3806 26541 SGTC_2479 5617353 43.85 µM -0.738805070062151 0.243377234685566 no 2566 0.230012686346469 3751 2731746 SGTC_2856 9022925 19.48 µM -0.740779764960913 0.242760773093087 no 2567 0.22941349309684 3744 4944862 SGTC_2056 5235370 200 µM -0.740970847394207 0.242701165730386 no 2568 0.229355558294579 3730 5511916 SGTC_1653 st012112 65 µM -0.742708727749481 0.242159405153951 no 2569 0.228829022277371 3751 720429 SGTC_954 1189-0853 2.85 µM -0.742912153022502 0.242096032981418 no 2570 0.228767433693934 3713 2828194 SGTC_963 1269-2853 151 µM -0.742997504874258 0.242069446376108 no 2571 0.228741595528668 3752 3668223 SGTC_2802 7925815 54.55 µM -0.746759866390718 0.240899067249676 no 2572 0.227604262697735 3765 1262923 SGTC_2041 5107442 45.335 µM -0.747725116111427 0.240599298471909 no 2573 0.227312989216154 3741 793005 SGTC_828 2074-0507 139 µM -0.747838513751199 0.240564094939121 no 2574 0.227278784168583 3799 X828 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.749071803953342 0.240181409478851 no 2575 0.22690696422494 3819 688788 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.751351222833534 0.239474988255457 no 2576 0.226220654838231 3724 390807 SGTC_2807 7945238 51.95 µM -0.752842452971322 0.239013451463174 no 2577 0.225772296285194 3802 17148797 SGTC_1975 st070967 30.8 µM -0.754429793012264 0.238522703394457 no 2578 0.225295593748968 3734 261391 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.755130037156604 0.238306388721441 no 2579 0.225085481028728 3725 5355888 SGTC_2587 piperic acid 92.2 µM -0.756210536231824 0.237972819195867 no 2580 0.224761488331896 3777 5370536 SGTC_390 dec-rvkr-cmk 16.7 µM -0.756775203413919 0.237798598156882 no 2581 0.224592275509055 3824 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_2854 9024559 71.43 µM -0.757372766502222 0.237614303708224 no 2582 0.224413283561976 3777 3163529 SGTC_1749 st037932 54.2 µM -0.757445555411612 0.237591860234714 no 2583 0.224391486160852 3796 594497 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.75767866751297 0.237519991107353 no 2584 0.22432168638845 3765 442882 SGTC_1402 3909-7673 35.9 µM -0.760204129729525 0.236742149255963 no 2585 0.22356628842683 3775 5328014 SGTC_1636 st007707 68.9 µM -0.760940268911251 0.236515682523104 no 2586 0.223346372432705 3781 403051 SGTC_2981 9013952 38.96 µM -0.76130250059433 0.236404288918062 no 2587 0.223238203672835 3683 2996344 SGTC_698 k064-0052 127 µM -0.761826511018179 0.236243196182606 no 2588 0.223081777714131 3829 5088751 SGTC_1027 k015-0025 8.67 µM -0.763438976453476 0.235747867026431 no 2589 0.222600821284303 3762 3598955 SGTC_2408 sulbentine 18.36 µM -0.764069489922711 0.235554337057148 no 2590 0.22241291643509 3779 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_2207 7258803 200 µM -0.764273662394216 0.235491687097219 no 2591 0.222352088602787 3725 3666799 SGTC_83 0170-0301 39.027 µM -0.768218041930021 0.234283167525655 no 2592 0.221178828238509 3720 3089716 SGTC_2245 6637752 200 µM -0.771244167759317 0.233358324044929 no 2593 0.220281109508828 3838 681890 SGTC_1683 st010134 710 nM -0.771386429556667 0.233314895956034 no 2594 0.220238958154084 3801 3818134 SGTC_148 3253-0744 288.01 µM -0.771758607799164 0.233201302765398 no 2595 0.220128705754978 3748 6893655 SGTC_1029 k015-0030 64.7 µM -0.772607694778051 0.23294226634468 no 2596 0.219877294597941 3883 2208316 SGTC_2662 daunorubicin 22.37 µM -0.774553692119919 0.232349191755449 no 2597 0.219301714869883 3684 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_3003 9075612 71.4286 µM -0.774731501451613 0.232295043360806 no 2598 0.219249166309812 3815 6501993 SGTC_1179 1021-1431 9.29 µM -0.775105927696861 0.232181042048003 no 2599 0.21913853459515 3815 2840958 SGTC_1393 3470-5649 58.2 µM -0.775296182792182 0.232123127136529 no 2600 0.219082332226276 3757 4108395 SGTC_229 benomyl 22.8748 µM -0.776622037895112 0.231719751409484 no 2601 0.218690897780311 3807 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_2616 abietic acid 100 µM -0.777085232604385 0.231578922014014 no 2602 0.218554242960628 3793 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_729 4092-0585 94.1 µM -0.77746759195787 0.231462705697902 no 2603 0.218441473784981 3790 2169061 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.778808601541045 0.231055369307201 no 2604 0.218046235032891 3790 688667 SGTC_20 0481-0013 4.944 µM -0.780915032912418 0.230416341934468 no 2605 0.217426234914616 3814 182045 SGTC_841 0251-0215 91.2 µM -0.781270545770153 0.230308587653287 no 2606 0.217321694900472 3841 3888614 SGTC_2394 5221648 200 µM -0.782939371637189 0.229803151132249 no 2607 0.216831357893992 3887 788586 SGTC_1933 st074711 15.9 µM -0.78408385957771 0.229456879935073 no 2608 0.216495452746067 3796 17250958 SGTC_1786 berberine 21.6 µM -0.784798162239295 0.229240911973855 no 2609 0.216285958897367 3754 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_236 1509-0011 5.31 µM -0.784851545389989 0.229224776265184 no 2610 0.216270307164968 3869 3107280 SGTC_2296 7971656 126.45 µM -0.785901591049343 0.228907516650751 no 2611 0.215962571187438 3880 666570 SGTC_416 estradiol valerate 100 µM -0.786346158823629 0.228773269730821 no 2612 0.215832358573452 3845 13791 A steroid. SGTC_1262 0737-0114 49.6 µM -0.786452525579415 0.228741156526577 no 2613 0.215801210805546 3846 765919 SGTC_1789 tunicamycin 25 nM -0.786553083277703 0.228710799463214 no 2614 0.215771766521209 3755 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_195 4234-0266 16.654 µM -0.787927088334393 0.228296231868715 no 2615 0.215369677659355 3808 2303354 SGTC_2015 5119600 184 µM -0.788818035050931 0.228027639507311 no 2616 0.215109183502594 3837 2828786 SGTC_2422 chlorphenesin carbamate 384.24 µM -0.789830140123279 0.227722737466838 no 2617 0.214813487217417 3821 2724 A muscle relaxant with antifungal properties. SGTC_2080 5212524 12.4 µM -0.789963991748015 0.227682431140838 no 2618 0.214774398858861 3751 260183 SGTC_2713 st079149 53.4 µM -0.79044852352421 0.227536559171321 no 2619 0.214632936804645 3852 3103253 SGTC_815 1582-0027 36.9 µM -0.790506822112607 0.227519011486557 no 2620 0.214615919821201 3872 3128206 SGTC_3071 9117417 49.47 µM -0.791908282292605 0.227097405988624 no 2621 0.214207078669423 3756 45595590 YGL055W OLE1 SGTC_825 1988-2224 89.6 µM -0.793386217209863 0.226653271909726 no 2622 0.213776419206789 3811 1180859 SGTC_723 4182-0001 115 µM -0.795322903450004 0.2260720213062 no 2623 0.213212846984114 3800 744821 YLR208W SEC13 SGTC_479 n-linoleoylglycine 10 µM -0.795631088117169 0.225979604726185 no 2624 0.213123245775225 3852 6433346 An anti-infammatory. SGTC_393 acivicin 6.25 µM -0.7963377131027 0.225767786888491 no 2625 0.212917885480714 3698 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_1226 3909-7979 35.4 µM -0.796857982156971 0.225611902897134 no 2626 0.212766758035773 3847 6615510 SGTC_942 3253-1115 227 µM -0.796945918807233 0.225585561171198 no 2627 0.212741220438244 3875 46497897 SGTC_3303 9125618 40.5795 µM -0.796965320148971 0.225579749666942 no 2628 0.212735586354335 3866 22695467 SGTC_2200 6600604 21.907 µM -0.798169915458304 0.225219089526879 no 2629 0.212385946604245 3786 2904777 SGTC_2289 7946404 165.07 µM -0.800020768600058 0.224665574456599 no 2630 0.211849382145379 3861 1246120 YPR165W RHO1 SGTC_1521 st012942 49.4 µM -0.800599916606894 0.22449253341265 no 2631 0.211681649517756 3878 24207259 SGTC_1085 doxorubicin 7.67 µM -0.80131454247798 0.224279117815058 no 2632 0.211474787008537 3830 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_3233 9132340 49.47 µM -0.801416719218639 0.224248613207022 no 2633 0.211445219617649 3840 17682950 SGTC_3127 9126946 49.47 µM -0.802392662134558 0.223957366647998 no 2634 0.21116292818594 3840 27243249 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.802625325836026 0.223887965533599 no 2635 0.21109566283946 3813 2724278 An inhibitor of dopamine biosynthesis. SGTC_1761 st044296 37 µM -0.80341895229165 0.223651327148653 no 2636 0.210866312185777 3837 1826700 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.804496654073969 0.223330212837187 no 2637 0.210555100466964 3831 6708760 SGTC_1872 amphotericin b 148 nM -0.805173498098921 0.223128673163505 no 2638 0.210359783723723 3866 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_216 k038-0035 28.382 µM -0.806504619082065 0.222732615710193 no 2639 0.209975972872065 3755 4444231 YPR107C YTH1 SGTC_1836 st055642 81 µM -0.808110832419996 0.222255242011331 no 2640 0.20951339113456 3856 8571 SGTC_1549 4'-methoxyflavonol 74.6 µM -0.808555145812292 0.22212329326176 no 2641 0.209385536940562 3790 97141 SGTC_1245 0418-0076 17.2 µM -0.808624847732882 0.222102597783326 no 2642 0.209365483906888 3902 6790114 SGTC_2651 TUB2.036 5 µM -0.810237381189918 0.221624121335417 no 2643 0.208901878459349 3894 15992207 YFL037W TUB2 SGTC_1060 3448-7350 82 µM -0.811061681706786 0.221379759766184 no 2644 0.208665124775026 3774 570178 SGTC_3039 9090270 49.47 µM -0.812773485659925 0.220872792790759 no 2645 0.208173969961482 3808 17173750 SGTC_1068 loratadine 26.9 µM -0.81430979938295 0.220418365413579 no 2646 0.207733748654405 3904 3957 A H1 histamine antagonist. SGTC_107 0358-0022 2.6945 µM -0.814509117825318 0.220359448160416 no 2647 0.207676675500789 3887 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_481 bay k-8644 50 µM -0.815415136704606 0.220091748602391 no 2648 0.207417361427621 3829 2303 A calcium channel antagonist. SGTC_492 tmb-8 126 µM -0.815621331014711 0.220030850857043 no 2649 0.207358372754264 3779 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_3024 9090631 49.47 µM -0.819280066022978 0.218951883159834 no 2650 0.20631332151082 3790 25236383 SGTC_1295 1013-0063 9.78 µM -0.819376581126369 0.218923461939337 no 2651 0.206285796047266 3834 6826038 SGTC_529 4076-0302 30.3 µM -0.820604165531873 0.218562155047513 no 2652 0.205935887103672 3820 5816522 SGTC_2581 avocatin a 64 µM -0.823041794855478 0.217845722193819 no 2653 0.205242113187421 3874 6710728 A skin care supplement. SGTC_1440 4100-1550 40 µM -0.823804347160999 0.217621882254086 no 2654 0.205025368569271 3870 742806 SGTC_1963 st076565 50.3 µM -0.824283863934669 0.217481192687371 no 2655 0.204889142470666 3881 4914280 SGTC_2977 9011197 71.43 µM -0.827813739190476 0.216447149181557 no 2656 0.203887996291678 3957 2704722 SGTC_149 3970-0822 46.1 µM -0.827908381097561 0.216419463952825 no 2657 0.203861194067665 3879 3114250 YBL034C STU1 SGTC_233 rapamycin 362 pM -0.828515866931154 0.216241807288453 no 2658 0.203689206420309 3876 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_70 0141-0289 43.283 µM -0.829174153842602 0.216049389420907 no 2659 0.20350293398511 3898 352408 SGTC_1859 st055998 20 µM -0.829652789636831 0.215909546032996 no 2660 0.203367560424536 3821 676301 SGTC_978 1416-0512 87.4 µM -0.830152190605281 0.215763691595698 no 2661 0.203226371101109 3938 6814003 SGTC_1180 1193-0155 285 µM -0.830817048984427 0.215569602526393 no 2662 0.203038494914593 3910 2921347 SGTC_924 2046-0044 21.3 µM -0.831185839460813 0.21546198687868 no 2663 0.202934326554945 3870 3623589 SGTC_2935 9038016 29.96 µM -0.832258435395426 0.215149173038408 no 2664 0.202631543157063 3900 6463195 SGTC_1406 3909-7906 11.9 µM -0.836769639623452 0.21383640668857 no 2665 0.201361033022336 3885 X1406 SGTC_2989 9073649 71.4286 µM -0.837484967749176 0.213628674555013 no 2666 0.201160011545225 3803 21367202 SGTC_2107 5363541 170.161 µM -0.839105868786555 0.213158398254934 no 2667 0.20070495153556 3876 244052 SGTC_1076 itraconazole 331 nM -0.840324932391774 0.212805106283541 no 2668 0.200363112907525 3884 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_297 0986-0032 24 µM -0.840711070394381 0.212693272487171 no 2669 0.200254908615308 3850 2847425 SGTC_1401 3807-4679 7.6 µM -0.841063390710894 0.212591262959641 no 2670 0.200156211418003 3835 3291456 SGTC_1937 st074714 47.2 µM -0.841290757927428 0.212525447065393 no 2671 0.20009253346249 3847 17250970 SGTC_383 2324-0395 7.37 µM -0.844586463182832 0.211572778036295 no 2672 0.199170884840019 3914 3146421 SGTC_2659 sanguinarine 24.21 µM -0.844978115760136 0.211459731903845 no 2673 0.199061528899532 3830 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_2297 7971671 152.32 µM -0.845666804000526 0.211261035557941 no 2674 0.19886932339843 3883 909016 SGTC_1161 k007-0610 110 µM -0.845709299294263 0.211248778645737 no 2675 0.19885746708315 3888 5843850 SGTC_1518 st038567 90.8 µM -0.846686292919295 0.210967099416253 no 2676 0.198585000431483 3862 77966 SGTC_1503 4585-0012 61.3 µM -0.847136288773459 0.210837434202859 no 2677 0.19845958013527 3943 2922052 SGTC_701 4424-0219 185 µM -0.847870907617049 0.210625856024126 no 2678 0.198254934050678 3932 2911779 SGTC_1526 st051518 75 µM -0.849453675916236 0.210170425204465 no 2679 0.197814448221123 3910 673993 SGTC_1004 4084-0029 199 µM -0.849665209892371 0.210109601589505 no 2680 0.19775562295421 3931 716894 YLR208W SEC13 SGTC_2402 5553605 200 µM -0.85080347325797 0.209782487566802 no 2681 0.197439265977089 3964 6758546 SGTC_2141 5621638 7.665 µM -0.853238064384375 0.209083840864274 no 2682 0.19676364934016 3945 2856238 SGTC_1661 st013063 9.66 µM -0.854097031945647 0.208837673090043 no 2683 0.196525614160851 3940 721395 SGTC_820 1582-0060 59.9 µM -0.854221198156101 0.208802102968273 no 2684 0.196491219936805 3934 3848840 SGTC_582 0987-0078 156 µM -0.855611190558613 0.208404153032111 no 2685 0.196106439008197 3947 1625765 SGTC_1413 3910-0535 34.4 µM -0.856787164189353 0.208067825495283 no 2686 0.195781260385023 3908 2876951 SGTC_2991 9074669 71.4286 µM -0.856807304848092 0.208062068074556 no 2687 0.195775693969518 3885 17333109 SGTC_3144 9087057 49.47 µM -0.857508873263791 0.20786157600311 no 2688 0.195581856525758 3764 17249618 SGTC_3245 9134821 49.47 µM -0.858139198265003 0.207681540993959 no 2689 0.195407802457934 3921 17014901 SGTC_133 0724-0033 378.92 µM -0.858394859673807 0.207608544609022 no 2690 0.195337232518502 3766 280309 SGTC_2354 9060492 162 µM -0.858715079547028 0.207517136895831 no 2691 0.195248864421451 3985 6471895 SGTC_1659 st012954 42.1 µM -0.859251258166878 0.207364136385349 no 2692 0.195100954600078 3913 24207262 SGTC_3218 9131285 49.47 µM -0.860930223267462 0.206885469207382 no 2693 0.194638237308559 3866 17156417 SGTC_962 1254-0300 21.5 µM -0.864008287861739 0.206009623987994 no 2694 0.193791668861459 3891 7340576 SGTC_3072 9116419 49.47 µM -0.866662750750221 0.205256081010473 no 2695 0.193063410247637 3961 17170162 SGTC_1005 4092-0690 4.4 µM -0.867250349279094 0.205089496490006 no 2696 0.19290242727907 3959 1529343 SGTC_2551 apiole 73.87 µM -0.86727049958859 0.205083785291048 no 2697 0.192896908201206 3751 10659 A possible DNA adduct former. SGTC_1352 1496-0991 99 µM -0.868173460825825 0.204827956168409 no 2698 0.19264969024365 3916 3000039 SGTC_2800 7887935 81.82 µM -0.868612553749878 0.20470361993116 no 2699 0.192529542843924 3967 2961002 SGTC_1594 piperine 70.1 µM -0.870015527826037 0.204306646228534 no 2700 0.192145959240367 3910 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_3226 9131256 49.47 µM -0.871184697750417 0.203976178183213 no 2701 0.191826656882406 3838 17178073 SGTC_908 3448-7491 47.7 µM -0.871794412199687 0.203803967694765 no 2702 0.191660271750567 3948 1203031 SGTC_1116 jasmonic acid  1.58368 µM -0.875304391636483 0.202814280024267 no 2703 0.190704152614728 4003 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_553 k007-0256 45.7 µM -0.876214139679241 0.202558233176466 no 2704 0.19045681556057 3995 6287000 SGTC_721 1187-1332 279 µM -0.877241498374337 0.202269317472793 no 2705 0.190177740149413 3877 25730 SGTC_2842 9000675 19.48 µM -0.877416593496967 0.20222010149721 no 2706 0.190130201753324 4000 2989072 SGTC_3119 9125183 49.47 µM -0.877910421215685 0.202081334329028 no 2707 0.18999616667326 3762 22695334 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.878542371663251 0.201903837377435 no 2708 0.189824726965488 3942 688662 SGTC_2819 7996655 46.38 µM -0.880889360947935 0.20124545211325 no 2709 0.189188853212217 3904 6456960 SGTC_1192 1488-0095 21.4 µM -0.880922646559344 0.201236123989147 no 2710 0.189179844528345 3992 915875 SGTC_3173 9105693 49.47 µM -0.881675815454422 0.201025121524354 no 2711 0.188976071494937 3947 17096658 SGTC_1349 flufenamic acid 69 µM -0.882550183324724 0.200780331350221 no 2712 0.18873967724088 3873 3371 A non-steroidal anti-inflammatory. SGTC_3058 9093861 49.47 µM -0.883363241033203 0.200552866323883 no 2713 0.188520022430123 3945 17217477 SGTC_1906 st060206 94.7 µM -0.883485208334649 0.200518757504057 no 2714 0.188487085475305 3974 5133468 SGTC_1684 st024538 14.6195 µM -0.883772871499463 0.200438324732842 no 2715 0.18840941683665 3925 6732859 SGTC_3346 9158254 43.5805 µM -0.884205182062419 0.200317483919806 no 2716 0.188292730740421 3961 17639500 SGTC_2820 7989630 71.43 µM -0.884632961713117 0.200197952697025 no 2717 0.188177311491031 3888 2984098 SGTC_2847 9005661 71.43 µM -0.885698957107636 0.199900276243943 no 2718 0.187889885227384 3923 2991449 SGTC_1618 st003135 44.5 µM -0.886201129212308 0.199760138264445 no 2719 0.187754577638356 3854 1270615 SGTC_2075 5212009 200 µM -0.888604874025003 0.199090159370529 no 2720 0.18710773534713 3841 780898 SGTC_2082 5219693 150 µM -0.89024664915212 0.198633337993582 no 2721 0.186666730581998 3936 2834649 SGTC_2949 9072542 2.23 µM -0.892550070377364 0.197993481301124 no 2722 0.186049083833642 4037 16457352 SGTC_1444 4112-3581 28 µM -0.893571565704208 0.19771012374082 no 2723 0.185775582777049 3984 2877249 SGTC_3001 9076041 71.4286 µM -0.895165355464521 0.197268504438017 no 2724 0.185349350721107 3954 16004211 SGTC_2069 5228469 200 µM -0.89613540977203 0.197000006826752 no 2725 0.18509022361146 3989 2835210 SGTC_2844 9010103 25.97 µM -0.896203007193623 0.196981305043479 no 2726 0.185072174947163 4026 2480525 SGTC_1635 st007035 42.4 µM -0.897022393079271 0.196754695819178 no 2727 0.184853484021638 3943 3716403 SGTC_770 0389-1121 67.2 µM -0.897209285169755 0.196703031094478 no 2728 0.184803625748356 4098 6753108 SGTC_696 1560-0013 611 µM -0.897319879823691 0.196672462015788 no 2729 0.184774125716236 4025 1650269 SGTC_1792 st045773 43.6 µM -0.897387412822473 0.196653796872666 no 2730 0.184756113395073 3889 2919270 SGTC_3155 9099265 49.47 µM -0.897448852240018 0.196636816839386 no 2731 0.18473972729493 3997 25236499 SGTC_325 2810-4341 181 µM -0.897513891931691 0.196618842764869 no 2732 0.184722381973969 3971 774970 SGTC_3104 9120930 49.47 µM -0.897941635048785 0.196500658414521 no 2733 0.18460833314074 3992 17014836 SGTC_430 0958-0115 16.4 µM -0.89797492246934 0.196491462989388 no 2734 0.184599459576947 3933 6833180 SGTC_276 colchicine 750 µM -0.89879066976644 0.196266199809448 no 2735 0.184382085384131 4045 2833 A microtubule depolymerizer. SGTC_3354 9151612 71.43 µM -0.899648393710169 0.196029513997555 no 2736 0.184153697396781 3999 27261949 SGTC_277 nystatin 15.5 µM -0.901937665544315 0.195398646012679 no 2737 0.183544990750573 3955 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2650 prasterone 100 µM -0.902167521062081 0.195335371590134 no 2738 0.183483942597112 3935 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_2393 9031399 185.94 µM -0.902889227340198 0.195136781844001 no 2739 0.183292344301727 4025 1526623 YDL150W RPC53 SGTC_1317 1273-0028 910 nM -0.903446393425219 0.194983552096657 no 2740 0.183144513440482 3943 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_1019 4262-0212 3.4 µM -0.906048903131429 0.194268788959224 no 2741 0.182454984415451 3999 4677213 SGTC_1054 3429-0080 167 µM -0.906456684069892 0.194156939221147 no 2742 0.182347090927557 4022 1162877 SGTC_1695 st026914 34.495 µM -0.906910529745356 0.194032500574793 no 2743 0.182227056199412 3941 3289191 SGTC_64 000l-0018 272.079 µM -0.907300787516306 0.193925535780831 no 2744 0.182123878927059 3919 6811119 SGTC_2701 st077767 14.721 µM -0.9077071968972 0.193814182237336 no 2745 0.182016470279456 3950 5721188 SGTC_724 3910-0327 137 µM -0.908484262243884 0.193601379889871 no 2746 0.181811212431548 4028 2885483 SGTC_2946 9065502 71.43 µM -0.909316314344113 0.193373677250828 no 2747 0.181591590702274 3802 16489101 SGTC_2144 5628481 200 µM -0.90989276720518 0.193216018764604 no 2748 0.181439532277117 3969 2818399 SGTC_796 1234-0020 70.7 µM -0.91438216286281 0.191990866400961 no 2749 0.180258035554842 3915 46495034 SGTC_3152 9099253 49.47 µM -0.915269796689174 0.1917491960124 no 2750 0.180025005490896 3924 25236131 SGTC_2823 7987624 58.44 µM -0.915534402061823 0.191677189655556 no 2751 0.17995557538883 3990 2239440 SGTC_1438 4092-1045 4 µM -0.916269968416603 0.191477108957791 no 2752 0.179762657662434 3974 1351342 SGTC_3125 9127534 49.47 µM -0.91815662890619 0.190964505576525 no 2753 0.17926843560059 3875 1639235 SGTC_2944 9067346 25.62 µM -0.91890280882439 0.190762001898169 no 2754 0.179073205319734 3956 6473075 SGTC_448 monastrol 171 µM -0.919391880936279 0.190629345505486 no 2755 0.178945317241691 3908 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_1407 3909-7909 12.3 µM -0.921913621034492 0.189946245398732 no 2756 0.178286816834305 3972 4411780 SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.921948668044962 0.189936762323944 no 2757 0.178277675802522 3975 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_1721 st082152 9.2685 µM -0.922460769251888 0.189798230379167 no 2758 0.178144142224244 3945 5296051 SGTC_2614 arthonioic acid 13.39 µM -0.922835409688831 0.189696923237634 no 2759 0.178046492342276 3898 6710684 SGTC_817 1391-0715 46 µM -0.924230420907065 0.189319988525001 no 2760 0.177683180088399 4009 1353946 SGTC_2243 6634756 200 µM -0.924523709830355 0.189240799989798 no 2761 0.177606856412044 4083 885676 SGTC_3309 9129340 25.759 µM -0.925073965977027 0.189092284875615 no 2762 0.177463717022049 4019 17158987 SGTC_328 k915-0120 63.5 µM -0.925395873405326 0.18900543477736 no 2763 0.177380012278231 3992 6624543 SGTC_440 fluspirilene 35.1 µM -0.927058157288176 0.188557344472675 no 2764 0.176948169761466 4103 3396 An atypical antipsychotic. SGTC_2926 9010726 65.15 µM -0.929604714913569 0.187872158266127 no 2765 0.176287892673513 4054 2994293 SGTC_878 0828-0289 13.7 µM -0.930554084012327 0.1876171114407 no 2766 0.176042137631788 3964 745350 YLR208W SEC13 SGTC_2958 9077254 16.72 µM -0.933862166379425 0.186730071820869 no 2767 0.175187498451996 4091 16457351 SGTC_3131 9127911 49.47 µM -0.934111109235 0.186663424696986 no 2768 0.175123290997275 4062 45595681 SGTC_2780 5215298 71.43 µM -0.937013382394246 0.185887513518983 no 2769 0.174375837104044 4053 2834131 SGTC_730 1436-0052 41.2 µM -0.937109763237643 0.185861780844618 no 2770 0.17435104992035 4028 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_1649 st011737 51.3 µM -0.938282877118564 0.185548748854861 no 2771 0.174049528459301 4004 1761035 SGTC_1681 tripelennamine 100 µM -0.938479332737258 0.185496358927205 no 2772 0.173999066565951 3984 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_1016 4226-1401 38 µM -0.941394419554997 0.184720055462503 no 2773 0.173251386145411 3985 2901613 SGTC_2711 st079103 59.1 µM -0.941820258199113 0.184606821629336 no 2774 0.173142335786875 3975 54693780 SGTC_284 0988-0104 32.6 µM -0.94260492156669 0.184398286561828 no 2775 0.17294151076794 4007 4666532 SGTC_2785 7756463 72.73 µM -0.942983557218871 0.184297711377309 no 2776 0.172844656701107 3980 2201551 SGTC_1174 0739-0097 51.1 µM -0.943787686334628 0.184084227641672 no 2777 0.172639077144423 4054 728447 SGTC_359 0081-0058 15.9 µM -0.947043183172258 0.183221518198749 no 2778 0.171808387353492 4110 3494159 SGTC_3252 9135871 49.47 µM -0.948310941182779 0.182886244522402 no 2779 0.17148559126263 4047 17682838 SGTC_2020 4017018 200 µM -0.949585276147397 0.182549617642761 no 2780 0.171161511415001 4119 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_213 1246-0773 967 nM -0.956068454514203 0.180843027177256 no 2781 0.169518825481272 4022 6251622 SGTC_2355 9061122 103.12 µM -0.957293177820754 0.180521765411958 no 2782 0.169209648893617 4056 5302957 SGTC_1477 0139-0234 16 µM -0.957354469233814 0.180505697242561 no 2783 0.169194185635471 4055 620880 SGTC_1194 1488-0194 225 µM -0.957608747034461 0.180439045303898 no 2784 0.169130043382191 3992 1391452 SGTC_2404 5161160 200 µM -0.958291511830263 0.180260153672755 no 2785 0.168957891405694 4005 2831543 SGTC_805 3852-0218 479 µM -0.95901637927033 0.180070352559059 no 2786 0.168775246918906 3983 6615355 SGTC_594 1487-1584 10.8 µM -0.96009147916728 0.179789076841706 no 2787 0.168504588262884 4004 5013332 SGTC_1753 st043925 64 µM -0.962746288729228 0.179095688683572 no 2788 0.167837430521096 4099 670181 SGTC_2279 7948423 32.93 µM -0.963314130671611 0.178947597346612 no 2789 0.167694952039357 3969 1247112 SGTC_1743 st037606 46.3785 µM -0.963350889273088 0.178938013478979 no 2790 0.167685731542211 4015 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_218 alverine citrate 93.75 µM -0.964422786975423 0.178658685553014 no 2791 0.167417001193633 4089 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_2137 5261020 140 µM -0.966069942727065 0.178229985464274 no 2792 0.167004591820878 4009 763655 SGTC_1253 0550-0034 176 µM -0.96659499421517 0.178093468333116 no 2793 0.166873268999574 4080 5969915 SGTC_1355 1499-0035 1.68 µM -0.970623547609465 0.177048210046319 no 2794 0.165867887754968 4040 1548538 SGTC_583 1488-1091 88.9 µM -0.97342529500217 0.176323551809009 no 2795 0.165170986115275 4175 4303273 SGTC_929 2805-0021 398 µM -0.975534559347865 0.175779241022218 no 2796 0.164647583803165 4118 3098024 SGTC_2712 st079126 47.7 µM -0.978410980196749 0.175038677492921 no 2797 0.163935549852266 4067 3152970 SGTC_3116 9124943 49.47 µM -0.979314368274393 0.174806500184017 no 2798 0.163712336595291 4047 41905195 YPL160W CDC60 SGTC_2838 9002687 71.43 µM -0.982447321927173 0.174002823648924 no 2799 0.162939761408846 4040 6457060 SGTC_85 0868-0259 160.055 µM -0.982662147887694 0.173947801918639 no 2800 0.162886873075253 3989 83173 SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.98451246311456 0.173474352911627 no 2801 0.162431803297525 3929 6708630 An antioxidant. SGTC_2978 9011784 42.97 µM -0.985113321109185 0.173320785082254 no 2802 0.162284205369411 4059 2994934 SGTC_2630 antimycin a 100 µM -0.986202588533248 0.173042609884495 no 2803 0.162016854657377 4023 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_2757 clomiphene 4.22 µM -0.987282431230905 0.172767122453912 no 2804 0.161752100487579 4140 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_129 0088-0017 176.636 µM -0.988165626874355 0.172542011190933 no 2805 0.161535769663264 3930 182446 SGTC_65 0798-0905 34.986 µM -0.988771436937658 0.172387708906477 no 2806 0.161387491060214 4191 3602145 SGTC_1042 0350-0096 82 µM -0.988935801697308 0.172345859719783 no 2807 0.161347276310814 4055 3122515 SGTC_871 0574-0004 149 µM -0.993335831644317 0.171227970353538 no 2808 0.160273160634821 4055 9551173 SGTC_530 4358-1714 28 µM -0.993368537117111 0.171219678466166 no 2809 0.160265194259387 4090 1564641 SGTC_1910 st062352 60.4 µM -0.994362977192087 0.170967678576456 no 2810 0.160023092838069 4004 2245730 SGTC_656 4090-1979 187 µM -0.996822943115322 0.170345321551186 no 2811 0.159425229874421 4149 22330961 SGTC_151 3013-0144 2.285 µM -0.998460574307905 0.169931816044119 no 2812 0.159028036596321 3986 906558 YHR107C CDC12 SGTC_2902 5787006 60.46 µM -0.998571259521563 0.169903891018086 no 2813 0.159001214267432 4046 591003 SGTC_918 glabranin 770.725 nM -1.00490949231204 0.168309712937736 no 2814 0.157470216632058 4101 124049 Also referred to as licorice root. SGTC_2563 tomatine 8.54 µM -1.00611018791885 0.168008804080803 no 2815 0.157181284221187 3994 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_1796 st049173 110.4 µM -1.00889898679517 0.167311234232512 no 2816 0.156511540591605 4050 94134 SGTC_2161 5662504 8.5105 µM -1.00906025210365 0.167270953674694 no 2817 0.156472869496747 4059 2859334 SGTC_3093 9117344 49.47 µM -1.00909547090842 0.167262157616838 no 2818 0.156464424935726 4129 24824913 SGTC_96 0929-0093 37.281 µM -1.01073876448802 0.166852069031813 no 2819 0.156070739200816 4094 6991579 SGTC_287 k060-0039 29.6 µM -1.01099207245041 0.166788913053818 no 2820 0.156010112038793 4153 5861974 SGTC_2426 5582046 32.21 µM -1.01243165233821 0.166430282908255 no 2821 0.155665855329161 4116 2251934 SGTC_1283 0922-0125 16.4 µM -1.01349574995194 0.166165513689037 no 2822 0.15541171257179 4103 3360884 SGTC_2764 methyldopa 94.69 µM -1.01402461688045 0.166034022075502 no 2823 0.155285503042123 4104 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_348 k064-0012 10.7 µM -1.01474037667254 0.165856170592928 no 2824 0.15511480090196 4012 5066323 SGTC_2645 abamectin 100 µM -1.01523633060282 0.165733008565659 no 2825 0.154996593133241 4061 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_1907 st060210 83.7 µM -1.01591090529514 0.165565583937353 no 2826 0.154835907641427 4149 688793 SGTC_2027 5150920 200 µM -1.01925829007389 0.164736405738062 no 2827 0.154040180027663 4051 786715 SGTC_2337 9009472 200 µM -1.02521722119421 0.163266992603421 no 2828 0.152630352125732 4089 5742383 SGTC_1261 0712-0010 12.7 µM -1.02594271646152 0.163088675994324 no 2829 0.152459293065105 4158 2840123 SGTC_221 trifluoperazine 10.304 µM -1.02654250267269 0.162941352535544 no 2830 0.15231797010085 4082 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_1053 3366-3204 134 µM -1.02907552687322 0.162320128993168 no 2831 0.15172209266552 4159 3632071 YPR165W RHO1 SGTC_1696 st025591 34.7925 µM -1.02992012906024 0.162113333717361 no 2832 0.151523750368366 4132 2787147 SGTC_2669 eugenol 100 µM -1.03277584812358 0.161415401071437 no 2833 0.150854404377185 4108 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_554 4483-2211 187 µM -1.03390625669707 0.161139673369724 no 2834 0.150589994881631 4173 747107 SGTC_454 lyso-paf C-16 6.67 µM -1.03497859616459 0.160878394012439 no 2835 0.150339453560305 4139 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_368 fentichlor 4.58 µM -1.03500882668664 0.160871032247809 no 2836 0.150332394530975 4172 7329 A pesticide. SGTC_674 0498-0004 451 µM -1.03630857756532 0.160554723711627 no 2837 0.150029102878626 4111 4231473 SGTC_2825 7998094 58.44 µM -1.03877624493953 0.159955308614936 no 2838 0.149454405870728 4138 2987815 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -1.03978820584361 0.1597099193541 no 2839 0.149219154897612 4081 16623 A steroid. SGTC_1414 3917-0015 5.4 µM -1.04049564601209 0.159538519350804 no 2840 0.149054842921538 4104 6618702 SGTC_2468 5987765 72.9 µM -1.04245155867676 0.159065263804433 no 2841 0.148601186537676 4171 26772094 SGTC_2280 7785178 200 µM -1.04818426100432 0.157683474448163 no 2842 0.147276860264102 4132 2954328 SGTC_1931 st074438 57.1 µM -1.04902310939451 0.15748194487134 no 2843 0.147083741257662 4102 2787313 SGTC_413 propylparaben 100 µM -1.05537140876948 0.155962284396272 no 2844 0.14562774690263 4090 7175 A pharmaceutical preservative. SGTC_1936 st074407 74.3 µM -1.05571224868678 0.155880968218219 no 2845 0.145549849694929 4185 809813 SGTC_462 ag-879 158 µM -1.05718695147168 0.155529461858447 no 2846 0.145213136893653 4173 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_1533 dihydroergotamine mesylate 29.4 µM -1.06061029451626 0.154715499954227 no 2847 0.144433521096835 4250 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_3270 9137563 49.47 µM -1.06097496960351 0.154628958025761 no 2848 0.144350638281345 4139 17015724 SGTC_2746 daunorubicin 9.88 µM -1.06127672672962 0.154557371503393 no 2849 0.144282079608941 4100 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_595 3909-8003 73.7 µM -1.06252273669107 0.154262009751657 no 2850 0.143999220861045 4225 699517 SGTC_427 1354-0053 47.3 µM -1.06969355544022 0.152569455197859 no 2851 0.142378634056108 4229 6813657 SGTC_211 3455-0679 143.504 µM -1.07024726204952 0.152439276204445 no 2852 0.142254012936504 4212 748649 SGTC_2588 indole-3-carbinol 100 µM -1.07074688108332 0.152321876735249 no 2853 0.142141628512228 4216 3712 Induces cell cycle arrest. SGTC_2915 7971052 15.16 µM -1.07104962394973 0.152250768039084 no 2854 0.142073558705152 4077 5741558 SGTC_1758 st042942 75.2445 µM -1.07108496739267 0.152242467955331 no 2855 0.142065613395479 4126 669317 SGTC_3075 9116269 49.47 µM -1.07146352867697 0.152153585147327 no 2856 0.14198053057133 4200 17015205 YNL244C SUI1 SGTC_2558 carylophyllene oxide 100 µM -1.07419006367611 0.151514437050396 no 2857 0.14136875243332 4292 6708694 An oxygenated terpenoid and antifungal agent. SGTC_1828 st055811 49 µM -1.07508590067588 0.15130482714457 no 2858 0.141168135647092 4180 5877589 SGTC_1808 st050063 61.5 µM -1.07904481095206 0.150380823052828 no 2859 0.140283875976447 4158 4011993 SGTC_3143 9086658 49.47 µM -1.08053566739115 0.150033835823911 no 2860 0.139951856368584 4214 25236626 SGTC_2747 doxorubicin 7.63 µM -1.08198162595269 0.149697808618514 no 2861 0.13963034622434 4158 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2624 nerol 100 µM -1.08210956372974 0.149668101276391 no 2862 0.139601923352683 4084 637566 A natural product oil. SGTC_2148 5546263 113.568 µM -1.08267115465239 0.14953774555938 no 2863 0.139477205910828 4155 792097 SGTC_2150 5556613 200 µM -1.08278347687903 0.149511682573229 no 2864 0.139452270622281 4174 743190 SGTC_1737 st035557 69.7 µM -1.0837600152982 0.149285216649412 no 2865 0.139235609013677 4039 5716916 SGTC_2687 chenodiol 100 µM -1.08482197632743 0.14903920073565 no 2866 0.13900025507603 4263 5702181 A cholesterol synthesis inhibitor. SGTC_1069 diphenylcyclopropenone 8.49 µM -1.08794071293168 0.148318274606328 no 2867 0.13831064068271 4204 65057 A dermal irritant. YDR527W RBA50 SGTC_1299 1079-1439 3.74 µM -1.09102559100083 0.147607473739117 no 2868 0.137630811079327 4144 323161 SGTC_1456 k015-0012 13 µM -1.09288642493735 0.147179815581549 no 2869 0.137221834638673 4210 2989616 SGTC_1877 wortmannin 25 µM -1.09351730734671 0.147035014473783 no 2870 0.137083367116783 4196 312145 A covalent inhibitor of PI 3-kinase. SGTC_2048 5246248 200 µM -1.10050893156745 0.145436682422209 no 2871 0.135555220129848 4220 677046 SGTC_678 1218-2179 85.9 µM -1.10224082998111 0.145042571590116 no 2872 0.135178492818297 4205 6820081 YOR116C RPO31 SGTC_473 2-arachidonoylglycerol 10 µM -1.10238641475409 0.145009475101492 no 2873 0.135146857557228 4029 5282280 An endocannabinoid. SGTC_2700 st077718 96.8 µM -1.10333403101286 0.144794173168353 no 2874 0.134941066623371 4186 904970 SGTC_2606 farnesol 9.78 µM -1.10918083611502 0.143470520422256 no 2875 0.133676089033389 4248 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_3044 9093193 49.47 µM -1.10935434963998 0.143431364070439 no 2876 0.133638673733047 4228 25236277 SGTC_577 r071-0003 38.6 µM -1.11043281501785 0.14318815135475 no 2877 0.133406282114586 4196 4568517 YMR134W ERG29 SGTC_203 k066-0004 30.888 µM -1.11126009776652 0.143001773602679 no 2878 0.133228204751128 4293 6795412 SGTC_2803 7707263 71.43 µM -1.1125901912882 0.142702461863788 no 2879 0.132942237511787 4181 2199229 SGTC_2450 5739737 12.93 µM -1.11342655878686 0.142514470638033 no 2880 0.132762636864395 4232 2262825 SGTC_457 grayanotoxin iii 135 µM -1.11366975956693 0.142459837583433 no 2881 0.132710443567555 4046 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_429 1112-0049 25.5 µM -1.11569549794687 0.14200532256671 no 2882 0.132276249162388 4183 2836170 SGTC_278 4092-0821 23.9 µM -1.115781547229 0.141986037445226 no 2883 0.132257827165721 4213 877900 SGTC_787 4152-0075 138 µM -1.11690845774614 0.141733641107387 no 2884 0.132016733982952 4227 9566539 SGTC_2343 7990716 14.84 µM -1.11774075571725 0.141547424930205 no 2885 0.13183886542294 4210 6456862 SGTC_3246 9135460 32.98 µM -1.1199448524971 0.141055087117345 no 2886 0.131368631637 4184 41446951 SGTC_1860 st056228 74.6 µM -1.12084760799103 0.140853770698442 no 2887 0.131176367649032 4187 688679 SGTC_2184 6075246 200 µM -1.12520772790288 0.139884199632158 no 2888 0.130250509588178 4217 2267320 SGTC_2096 5468907 200 µM -1.12553183612578 0.139812308420865 no 2889 0.130181867191161 4230 759785 SGTC_1165 k072-0275 30.3 µM -1.12636962916449 0.139626591949472 no 2890 0.130004548248332 4199 6153523 YGL055W OLE1 SGTC_531 3788-1495 174 µM -1.12959131982054 0.138913991965707 no 2891 0.129324235131329 4189 2896655 SGTC_1781 st038725 66.3 µM -1.12985780171219 0.13885516039737 no 2892 0.129268073771746 4214 4270275 YIL048W NEO1 SGTC_905 2-aminofluorene 215 µM -1.13098396553029 0.138606723063205 no 2893 0.129030920160642 4242 1539 An established DNA mutagen. YPR165W RHO1 SGTC_667 1498-1044 59 µM -1.13204093122338 0.138373826829465 no 2894 0.128808613274363 4236 6739982 SGTC_2456 5770359 74.46 µM -1.1322766469106 0.138321924645633 no 2895 0.128759072499294 4236 3118787 SGTC_2463 5473429 200 µM -1.13350050495037 0.138052656952549 no 2896 0.128502064631731 4207 5399405 SGTC_1154 4088-0362 150 µM -1.13583788865842 0.137539390279496 no 2897 0.12801220839751 4229 6618304 SGTC_3251 9135047 49.47 µM -1.13736648491366 0.137204430836496 no 2898 0.127692555937632 4254 17682963 SGTC_621 3584-0052 32.1 µM -1.13788980917009 0.137089883570833 no 2899 0.127583248566234 4249 2273927 SGTC_281 1672-3440 14.9 µM -1.13989503217414 0.136651577411627 no 2900 0.127165017486898 4279 6833000 SGTC_105 0111-0055 734.78 µM -1.14231566853804 0.136123747052826 no 2901 0.126661415335035 4245 5179370 SGTC_1128 3448-9350 235 µM -1.14240333200204 0.136104657869252 no 2902 0.126643203456217 4278 619386 SGTC_459 nigericin 15.3 µM -1.14249102238423 0.136085564657297 no 2903 0.126624987809821 4306 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_320 4092-0846 5.34 µM -1.15122971738442 0.13419204043229 no 2904 0.12481887127205 4199 1359356 SGTC_37 0566-0070 1.56 µM -1.15139507846131 0.134156384876831 no 2905 0.124784868815409 4173 1626686 SGTC_2405 ticlatone 3.52 µM -1.15232316473002 0.133956389436249 no 2906 0.124594150709806 4075 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_169 k015-0017 16.025 µM -1.1539908696478 0.133597526944401 no 2907 0.12425195609946 4225 1840002 SGTC_279 1273-0055 2.93 µM -1.15554699244633 0.133263271794362 no 2908 0.123933250280595 4256 2847562 SGTC_2435 5706476 10.6 µM -1.15582636826545 0.133203322853605 no 2909 0.12387609261493 4233 5725375 SGTC_692 k241-0027 77.8 µM -1.15662678456318 0.133031670916071 no 2910 0.123712437133983 4303 3600480 SGTC_2270 7924575 90.91 µM -1.15666098075454 0.133024340822173 no 2911 0.123705448653102 4239 1262135 SGTC_1230 0170-0365 3.77 µM -1.15797918619464 0.132741989990184 no 2912 0.123436265186503 4296 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_1576 erythromycin ethylsuccinate 23.2 µM -1.15877171989002 0.132572433363615 no 2913 0.123274623891259 4254 3256 An antibiotic and ribosome inhibitor. SGTC_3100 9120536 49.47 µM -1.1593775293789 0.132442925639241 no 2914 0.123151166011765 4105 16421196 SGTC_2281 7943571 200 µM -1.16095342999734 0.132106443859126 no 2915 0.122830419303273 4358 1244024 SGTC_2060 5238662 140 µM -1.16108220221116 0.132078974859607 no 2916 0.122804235910621 4237 790130 SGTC_1259 0671-0132 43 µM -1.17030365958293 0.130122136236979 no 2917 0.120939394854135 4185 X1259 SGTC_1166 k206-0078 225 µM -1.17333600221531 0.129483064077759 no 2918 0.120330545118652 4284 5404595 SGTC_2908 7930301 100 µM -1.17705827257718 0.128701565729179 no 2919 0.119586124215911 4232 2223178 SGTC_2174 5790901 200 µM -1.17801951539202 0.128500283616506 no 2920 0.119394413105772 4259 786020 SGTC_82 0054-0107 293.755 µM -1.17948865128339 0.128193072172587 no 2921 0.119101826536775 4223 3104697 SGTC_3272 9137413 49.47 µM -1.18089210112453 0.127900073084058 no 2922 0.118822794809344 4167 17614870 SGTC_2254 7938975 95.19 µM -1.18165709310611 0.127740561332873 no 2923 0.118670894872821 4343 2969277 SGTC_389 tpck 16.7 µM -1.18204501342012 0.127659727266235 no 2924 0.118593920276039 4302 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_950 1165-0508 94.1 µM -1.18306184646518 0.127448010397508 no 2925 0.118392318691688 4286 6148369 SGTC_2312 7706453 155.7 µM -1.1848965521908 0.127066620636335 no 2926 0.118029175388477 4265 976098 SGTC_1622 st003707 19.4 µM -1.18672427790841 0.126687472289698 no 2927 0.117668197737129 4293 10140899 SGTC_3310 9130229 44.1445 µM -1.18678010270467 0.126675904255902 no 2928 0.117657184595708 4300 7761258 SGTC_3087 9117406 49.47 µM -1.1894951383224 0.126114181316702 no 2929 0.117122441497262 4308 42546093 SGTC_556 4058-0063 51.5 µM -1.19559608066272 0.124858278119196 no 2930 0.115927110840373 4318 6615692 SGTC_2995 9067767 71.4286 µM -1.20094643428292 0.123764100849327 no 2931 0.114885990233803 4291 11673567 SGTC_2145 5634607 200 µM -1.20154354976229 0.123642405077065 no 2932 0.114770211924554 4264 308662 SGTC_342 k048-0088 23.3 µM -1.20175389586207 0.123599555225015 no 2933 0.11472944643377 4272 6820570 SGTC_2093 5331342 194.4 µM -1.20198554468911 0.123552377803144 no 2934 0.114684564353862 4337 33839 SGTC_1150 3909-7983 10.9 µM -1.20325365216248 0.123294339503041 no 2935 0.114439089273354 4274 23965914 SGTC_665 3914-0008 307 µM -1.20655185419486 0.122624980473627 no 2936 0.11380238894065 4244 1069549 SGTC_2053 5265679 138 µM -1.20682812890075 0.122569027387612 no 2937 0.113749170403289 4197 764595 SGTC_1522 st012842 45.6 µM -1.20800181696593 0.122331523569424 no 2938 0.11352328172654 4136 3491067 YOR116C RPO31 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -1.20815055807085 0.122301447866243 no 2939 0.113494677780733 4311 551469 SGTC_2754 granisetron 64.02 µM -1.20994555482179 0.121938905708475 no 2940 0.113149892648373 4289 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_2217 6934799 96.0675 µM -1.21175492121918 0.121574225884557 no 2941 0.112803104390024 4264 675606 SGTC_2030 5175110 200 µM -1.21184331563222 0.121556429552138 no 2942 0.112786181930899 4294 2831986 SGTC_2460 5552655 174.22 µM -1.21287966666202 0.121347918915851 no 2943 0.112587915350165 4315 5401989 SGTC_3335 9143315 29.6265 µM -1.21356849164147 0.121209468656989 no 2944 0.112456272528226 4299 4899691 SGTC_2327 6189656 200 µM -1.2159966648373 0.120722304626574 no 2945 0.111993096251077 4380 5349088 SGTC_1378 2093-0007 380 nM -1.21955285773121 0.120011316324852 no 2946 0.111317213323845 4350 3618014 SGTC_1871 st057448 67.3 µM -1.21974341583754 0.119973301601864 no 2947 0.111281078832545 4335 691747 SGTC_1496 4469-0713 57.4 µM -1.22274723585925 0.119375186230078 no 2948 0.110712589995716 4283 746691 SGTC_1776 st049249 45.9 µM -1.22423042759169 0.119080632935904 no 2949 0.110432656888362 4323 1822314 SGTC_1225 1216-0074 20.6 µM -1.22527191808519 0.11887410585367 no 2950 0.110236392650299 4314 4241466 SGTC_2770 toltrazuril 17.5 µM -1.22657996150056 0.118615080007197 no 2951 0.109990252270843 4264 68591 Kills coccidiodes. SGTC_2670 beta-carotene 100 µM -1.23058567736142 0.117824328018488 no 2952 0.109238932375241 4266 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_331 k048-0133 24.5 µM -1.23112304807092 0.117718532299849 no 2953 0.109138423258977 4273 6813582 SGTC_43 0570-0105 72.5 µM -1.23257730369284 0.117432560615064 no 2954 0.108866754498146 4302 1114046 YDL195W SEC31 SGTC_2657 nystatin 74.44 µM -1.23388267324839 0.117176285847551 no 2955 0.108623313436756 4355 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2790 5423970 71.43 µM -1.23412617821282 0.117128523972384 no 2956 0.108577945059016 4355 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_3033 9090887 49.47 µM -1.23437531837166 0.117079671068374 no 2957 0.108531540874517 4328 19325384 SGTC_1845 st056753 3.01 µM -1.23561127074142 0.116837531542863 no 2958 0.108301546607428 4293 5375839 SGTC_1092 toremifene 6.32 µM -1.23744406249747 0.116479117082544 no 2959 0.107961134542723 4304 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2073 5212005 126 µM -1.23790392071723 0.116389311302436 no 2960 0.107875844199307 4195 691789 SGTC_2647 atorvastatin 60.16 µM -1.24000895260734 0.115978846395052 no 2961 0.107486041412919 4284 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_1057 3448-5381 134 µM -1.24026010327215 0.115929942667715 no 2962 0.107439602039625 4298 5497911 SGTC_361 000s-0510 1.45 µM -1.24064313224366 0.115855387963732 no 2963 0.10736880536776 4236 660 SGTC_1373 2887-0003 58.5 µM -1.24074436617352 0.115835688967152 no 2964 0.107350099543122 4270 776948 SGTC_1569 carminic acid 40.6 µM -1.2408099509474 0.115822928169422 no 2965 0.107337982159896 4399 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_995 3931-2021 34.6 µM -1.24175074230273 0.115639988710699 no 2966 0.107164270912023 4314 730143 SGTC_2774 tamoxifen 10.92 µM -1.24235117008679 0.11552334123815 no 2967 0.107053511702586 4305 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_2750 bromebric acid 70.15 µM -1.24311155825639 0.115375737640913 no 2968 0.106913363575971 4332 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_477 mead ethanolamide 10 µM -1.24338352784958 0.115322976517376 no 2969 0.10686326866066 4259 16061185 SGTC_497 capsazepine 133 µM -1.24503747839881 0.115002485302154 no 2970 0.106558987051458 4264 2733484 A calcium channel blocker. SGTC_2969 9091408 28.7 µM -1.25098812753049 0.113854649808114 no 2971 0.10546940452178 4277 4286311 SGTC_971 1315-0384 26.7 µM -1.25124808315839 0.113804693108832 no 2972 0.105421990207784 4360 6769120 SGTC_271 rotenone 740 µM -1.25131486639164 0.113791861633817 no 2973 0.105409811844789 4358 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -1.2517631262328 0.113705761389754 no 2974 0.105328095044979 4234 4330530 SGTC_613 3914-0030 117 µM -1.25334857303308 0.113401606708516 no 2975 0.105039439241279 4034 1145395 SGTC_275 trichlorophene 5.69 µM -1.25449363343115 0.113182297640507 no 2976 0.104831319187359 4367 62616 SGTC_2003 4023581 200 µM -1.25744738375724 0.112617974590661 no 2977 0.104295840196486 4345 16641307 SGTC_3166 9102297 49.47 µM -1.25835899475893 0.112444215005734 no 2978 0.104130977227802 4328 25237072 SGTC_2504 purpurogallin 52.29 µM -1.26251209735751 0.111655027879155 no 2979 0.103382288019654 4233 5281571 An antioxidant. SGTC_3148 9097893 49.47 µM -1.26343394438032 0.111480393977778 no 2980 0.10321663582903 4302 17174100 SGTC_399 oxolinic acid 75 µM -1.26393627512981 0.111385315193792 no 2981 0.103126450189172 4319 4628 A DNA gyrase inhibitor. SGTC_1282 0886-0010 32.4 µM -1.26658376835311 0.110885169240885 no 2982 0.102652079671693 4359 2836211 YNL267W PIK1 SGTC_1500 4488-1866 171 µM -1.26699836469692 0.110806992521028 no 2983 0.102577937310174 4396 2900003 SGTC_739 1486-1183 203 µM -1.26916572218699 0.110398956125164 no 2984 0.102190981883702 4348 4346692 SGTC_292 k038-0015 474 µM -1.26932903620119 0.110368253605611 no 2985 0.102161867223692 4330 46368540 SGTC_3299 9121982 43.1275 µM -1.27590025256245 0.109137960947407 no 2986 0.1009953908958 4364 17594604 YPL160W CDC60 SGTC_1114 scopoletin 1.73284 µM -1.27740376159686 0.108857857980087 no 2987 0.100729868719471 4367 5280460 A coumarin with genotoxic properties. SGTC_899 1083-0020 478 µM -1.28120919993679 0.108151217276964 no 2988 0.10006009777517 4410 767123 SGTC_3232 9132874 49.47 µM -1.28133687767257 0.10812756588835 no 2989 0.100037682546767 4306 3784940 SGTC_410 α-linolenic acid 100 µM -1.28152916739964 0.108091952616879 no 2990 0.100003930893495 4382 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2316 5844804 197.44 µM -1.28321569687602 0.107779958506984 no 2991 0.0997082590661078 4351 776813 SGTC_1669 st015249 58.4 µM -1.28454350161358 0.107534782315116 no 2992 0.099475926368458 4452 722793 SGTC_3282 9108498 15.4605 µM -1.28685393024682 0.107109125406944 no 2993 0.0990726027110308 4314 16459645 SGTC_1513 0337-0559 19 µM -1.28868804006099 0.106772088272224 no 2994 0.0987532810195625 4334 775073 SGTC_353 1988-1175 58.3 µM -1.29086542247918 0.106372965532688 no 2995 0.0983751736134785 4191 2788357 SGTC_476 mead acid 10 µM -1.29436902196037 0.105733005440268 no 2996 0.097768992801881 4419 5312531 An omega 9 fatty acid. SGTC_1233 0325-0408 14.2 µM -1.29528672451634 0.105565840781232 no 2997 0.0976106685424456 4399 12874 SGTC_1328 1441-0025 69.2 µM -1.29559560703663 0.105509619112726 no 2998 0.0975574216963892 4340 4562601 SGTC_2267 7931562 200 µM -1.29898202426595 0.104894655487452 no 2999 0.0969750491048659 4303 934880 SGTC_2441 5730946 39.09 µM -1.29906346905692 0.104879897371784 no 3000 0.0969610742896273 4423 1774275 SGTC_842 0271-0008 11.1 µM -1.3021010801741 0.104330543511114 no 3001 0.096440916984911 4406 1221709 SGTC_2153 5569715 200 µM -1.30776646695108 0.103311532228734 no 3002 0.095476265600838 4400 2054701 SGTC_2185 6113692 200 µM -1.31175717025194 0.102598090233962 no 3003 0.0948010401130574 4360 874150 SGTC_3237 9133362 49.47 µM -1.31528009194185 0.10197125853853 no 3004 0.0942078931520478 4349 43845137 SGTC_2738 aclarubicin 5.55 µM -1.31592122156792 0.10185748304943 no 3005 0.094100242573675 4390 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_1866 st057638 64 µM -1.31917626467772 0.101281265178868 no 3006 0.0935550957033628 4364 688802 SGTC_2575 plumbagin 510 nM -1.31976244427595 0.1011777507022 no 3007 0.0934571720612397 4288 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1484 3473-2379 286 µM -1.32003668834993 0.101129347944774 no 3008 0.0934113844971712 4507 671917 SGTC_2484 5809818 12.04 µM -1.32199289423123 0.100784576474343 no 3009 0.0930852585500763 4341 2870548 SGTC_803 4488-1585 147 µM -1.32314305858491 0.100582266336355 no 3010 0.0928939038815582 4384 747204 SGTC_373 0844-0104 25.9 µM -1.32585377790236 0.100106631913423 no 3011 0.0924440679241481 4404 5375804 SGTC_1290 0986-0249 10.2 µM -1.32677038637322 0.0999461719679669 no 3012 0.0922923246605654 4225 53329 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -1.33149437045481 0.0991221771915105 no 3013 0.0915131980614739 4280 4000243 SGTC_2390 9097792 176.6 µM -1.33438520381238 0.098620391775014 no 3014 0.0910388233225678 4431 4497149 SGTC_2961 9083290 32.55 µM -1.33448934303031 0.0986023502473205 no 3015 0.0910217685737724 4327 17741490 SGTC_917 harmaline 728.087 nM -1.33945242155262 0.0977453242415439 no 3016 0.0902117167691196 4333 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_1429 4049-0205 9.46 µM -1.34037998709582 0.09758575944697 no 3017 0.090060919365732 4446 22774478 SGTC_2499 avocadenofuran 51.48 µM -1.34045395836568 0.0975730427416099 no 3018 0.0900489016795982 4351 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_1439 4092-1168 46 µM -1.34201987672699 0.0973041243728028 no 3019 0.0897947754635604 4404 2886240 SGTC_1374 2889-5571 141 µM -1.34325527232115 0.0970923513840305 no 3020 0.0895946648649993 4413 2853281 SGTC_1130 3454-2858 15.9 µM -1.3469792930147 0.0964560224135591 no 3021 0.0889934509051449 4374 715628 YIL048W NEO1 SGTC_2451 5856223 45.7 µM -1.34702631663968 0.0964480070543821 no 3022 0.0889858785561441 4388 2179896 SGTC_3190 9110366 49.47 µM -1.35092173192064 0.0957857168253383 no 3023 0.0883602529633469 4414 17123768 SGTC_880 0833-0487 87.2 µM -1.35989217140418 0.0942733158551024 no 3024 0.086932024355066 4401 76075 SGTC_3136 9095672 49.47 µM -1.3599792404614 0.0942587229683882 no 3025 0.0869182466670964 4252 17217380 SGTC_1231 0242-0792 125 µM -1.36092001834703 0.0941011536231786 no 3026 0.086769483289762 4406 3707635 SGTC_2900 5328528 85.29 µM -1.36192257742095 0.093933450638258 no 3027 0.0866111600742295 4409 795359 SGTC_921 1561-0023 372 µM -1.37126862048475 0.0923806927257889 no 3028 0.0851456169444484 4399 24050882 SGTC_2739 tacrine 100.86 µM -1.37208376444298 0.0922461700813616 no 3029 0.0850186815266031 4464 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_1045 1348-1485 165 µM -1.37373072882859 0.0919748152058757 no 3030 0.084762646689149 4387 6810614 SGTC_2866 9034245 58.44 µM -1.3758897602931 0.0916199877919658 no 3031 0.084427882945743 4429 6462273 SGTC_1830 st055982 50.3 µM -1.37704688097006 0.0914302380314822 no 3032 0.0842488770000922 4407 455313 An antimicrobial agent. SGTC_392 N-ethylmaleimide 8.33 µM -1.37798073009947 0.0912773138517364 no 3033 0.0841046188720541 4371 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_1771 st048882 4.1505 µM -1.38017942071563 0.0909180122407896 no 3034 0.0837657043226502 4450 4580403 SGTC_1289 0976-0073 69.1 µM -1.38067358611854 0.0908374022334517 no 3035 0.0836896731748961 4478 3391136 SGTC_194 1486-1323 56.904 µM -1.38492627259305 0.0901458797753097 no 3036 0.0830375062782021 4503 5178754 SGTC_140 0062-0056 502.533 µM -1.38691852750968 0.0898232708678647 no 3037 0.0827333037868181 4339 3758964 SGTC_311 1315-0136 58 µM -1.38730495735164 0.0897607951822418 no 3038 0.0826743960575134 4447 6759207 SGTC_2002 4023503 131 µM -1.38794608665157 0.0896572124642649 no 3039 0.0825767313421883 4412 4736863 YCR052W RSC6 SGTC_2438 5259590 200 µM -1.39112083593832 0.0891456001103335 no 3040 0.0820943937917444 4438 1201127 SGTC_602 3130-1533 38.1 µM -1.39459748558553 0.0885878321496337 no 3041 0.0815686268787423 4482 720941 SGTC_1411 3909-8223 150 µM -1.39676452980533 0.0882414852272584 no 3042 0.08124219596756 4443 X1411 SGTC_2414 st077232 92.9 µM -1.39871372968207 0.087930818263831 no 3043 0.0809494226855107 4360 729801 SGTC_126 0417-1624 672.48 µM -1.39883415340645 0.08791165170207 no 3044 0.0809313609840076 4483 41912 YDL195W SEC31 SGTC_2933 9026794 32.47 µM -1.39913940792163 0.087863081550596 no 3045 0.0808855911435512 4369 17586027 SGTC_2741 miltefosine 3.04 µM -1.40208623111217 0.0873952306206569 no 3046 0.0804447490864286 4486 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_385 1494-0393 12.4 µM -1.40352208942694 0.0871679421860354 no 3047 0.0802306048324268 4407 3090647 SGTC_3320 9137005 35.139 µM -1.40547210772528 0.0868599722507343 no 3048 0.0799404688824301 4481 4908713 SGTC_3047 9092122 49.47 µM -1.41578933970627 0.0852440704124246 no 3049 0.0784185958370754 4431 17173831 SGTC_1017 4239-0030 168 µM -1.42190427006801 0.0842970301124586 no 3050 0.0775270217146512 4462 1149593 SGTC_336 4111-0029 111 µM -1.42474033510881 0.0838604886152464 no 3051 0.0771161375062374 4455 3131175 SGTC_767 0929-0023 86 µM -1.44019435467255 0.0815115165910244 no 3052 0.07490620997622 4487 1204563 SGTC_1108 betulinic acid 729.144 nM -1.44230351108124 0.081194816536531 no 3053 0.0746083850662433 4452 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_408 cantharidin 100 µM -1.44546198342809 0.080722294039853 no 3054 0.0741640819699041 4439 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1368 1852-0141 284 µM -1.44560736069407 0.0807005950043353 no 3055 0.0741436804700274 4445 2838987 SGTC_1240 0356-0016 42.1 µM -1.44763525780319 0.0803983698429561 no 3056 0.0738595425721789 4428 4305613 SGTC_1835 st008666 49.2 µM -1.44823383197906 0.0803093257438348 no 3057 0.0737758328845041 4417 690455 SGTC_576 1073-0113 22.7 µM -1.45680313924263 0.079042710489347 no 3058 0.0725853645554 4551 5439563 SGTC_2381 9035592 200 µM -1.45888806927552 0.0787368409989802 no 3059 0.0722979587009034 4483 4749657 SGTC_1801 st050089 28.441 µM -1.46375490335325 0.0780263438445933 no 3060 0.0716304641263782 4521 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_223 busulfan 5 mM -1.46388142571142 0.0780079382420036 no 3061 0.0716131746382333 4474 2478 A DNA alkylator. SGTC_1050 3232-1156 69.3 µM -1.46419178900297 0.0779628026761128 no 3062 0.0715707765447123 4439 700529 SGTC_1205 4161-2785 76 µM -1.465659044332 0.0777496906601609 no 3063 0.0713705985102663 4477 3498106 SGTC_2453 5731132 22.18 µM -1.4661227230795 0.0776824355092496 no 3064 0.0713074281382805 4504 1362040 SGTC_3183 9108214 49.47 µM -1.46664505847872 0.0776067253038947 no 3065 0.0712363179564376 4459 4974831 SGTC_337 1315-0038 354 µM -1.47785106700932 0.0759959261986678 no 3066 0.0697238231052261 4460 1626437 SGTC_3076 9116187 49.47 µM -1.47849347842372 0.0759043605951436 no 3067 0.0696378706940997 4481 27241210 SGTC_90 0870-0863 4.608 µM -1.48032823984147 0.0756433069445895 no 3068 0.0693928351879947 4496 1738164 SGTC_2784 7567673 72.73 µM -1.48063702489518 0.0755994396938988 no 3069 0.0693516617855993 4410 3471247 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -1.4810189667995 0.0755452063037848 no 3070 0.0693007596839987 4480 688669 SGTC_543 3844-1095 191 µM -1.48158566405011 0.0754647934273569 no 3071 0.0692252879335862 4496 4230703 SGTC_1467 k284-1082 293 µM -1.48260946811334 0.0753196836718492 no 3072 0.0690891000588731 4452 3334705 SGTC_2841 9004761 38.96 µM -1.48282863275505 0.075288647839159 no 3073 0.0690599733141734 4431 2991039 SGTC_2122 5258151 111.688 µM -1.48660256530311 0.0747557505882044 no 3074 0.0685599049439641 4493 2173356 SGTC_1531 st059297 52.4 µM -1.48768989469621 0.0746027498143159 no 3075 0.0684163468997773 4529 7566702 SGTC_521 r062-0005 13.8 µM -1.48896185901835 0.0744240720639836 no 3076 0.0682487063192948 4411 2832033 SGTC_3286 9117135 37.221 µM -1.49023011401688 0.0742462408554984 no 3077 0.068081870424284 4437 3438150 SGTC_3103 9120822 49.47 µM -1.49123448450685 0.0741056412027814 no 3078 0.0679499714385231 4499 17141819 SGTC_441 propafenone 146 µM -1.4935368583169 0.0737841044791643 no 3079 0.0676483567904794 4472 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_1308 1187-1617 41.4 µM -1.49444001899196 0.0736582656685456 no 3080 0.0675303241437305 4522 2882570 SGTC_2740 felodipine 17.08 µM -1.49470719509781 0.073621071062844 no 3081 0.06749543783855 4545 3333 L-type calcium channel blocker SGTC_2356 9061756 188.97 µM -1.49511558032776 0.0735642459472721 no 3082 0.0674421401817997 4521 20104043 SGTC_2898 9056270 58.44 µM -1.49874606784737 0.0730605519625912 no 3083 0.0669697603344196 4508 19154699 SGTC_834 0312-0008 75.7 µM -1.50055457758767 0.0728106261469188 no 3084 0.0667354035839538 4521 6385573 YIL048W NEO1 SGTC_2132 5317594 122.667 µM -1.50160105334908 0.072666308376541 no 3085 0.0666000855790899 4436 794577 SGTC_2737 bleomycin 30.5 nM -1.50201526129585 0.07260924618412 no 3086 0.0665465837554696 4589 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_573 3702-0553 84.7 µM -1.50307116195341 0.0724639382558988 no 3087 0.0664103471855369 4440 1222756 SGTC_2196 6573537 42.6665 µM -1.50439363833014 0.0722822598326749 no 3088 0.0662400206666727 4523 2903087 SGTC_3209 9113616 49.47 µM -1.51284947568492 0.0711288593464222 no 3089 0.0651589490563025 4529 16649353 SGTC_3009 9080819 71.4286 µM -1.51586126880837 0.0707214730209251 no 3090 0.0647772178313688 4512 17027216 SGTC_2147 5545932 89.7195 µM -1.51689641484123 0.0705818701046985 no 3091 0.0646464194689601 4547 797404 SGTC_2210 7115885 190.385 µM -1.51758024066932 0.0704897635335527 no 3092 0.0645601255899694 4579 2927039 SGTC_3068 9116768 49.47 µM -1.51768768311958 0.0704753001877788 no 3093 0.0645465752667072 4469 41904888 SGTC_500 h-89 112 µM -1.51819568067593 0.0704069470813477 no 3094 0.0644825380360497 4468 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_2550 chrysin dimethyl ether 71.87 µM -1.52955506599993 0.0688917740582091 no 3095 0.0630634494825713 4360 88881 An O-methylated flavonoid and antioxidant. SGTC_89 0302-0250 142.109 µM -1.53302821635573 0.0684335607815876 no 3096 0.0626344514031063 4588 4203518 YLR208W SEC13 SGTC_3185 9108267 49.47 µM -1.53629211811543 0.068005100187907 no 3097 0.0622333758700193 4500 4910486 SGTC_2745 rifampicin 24.3 µM -1.54053165998687 0.0674516608826842 no 3098 0.0617154058245327 4615 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_1579 chlormadinone acetate 49.4 µM -1.54621902214809 0.066714694817132 no 3099 0.0610258404995662 4538 45114258 A steroidal progestin. SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -1.55026659223089 0.0661940186794736 no 3100 0.0605387711444424 4490 756377 SGTC_3223 9129970 49.47 µM -1.55369655453406 0.0657552596333066 no 3101 0.0601284076638385 4532 17248386 SGTC_2480 5767542 37.17 µM -1.55398095618346 0.0657189805706307 no 3102 0.060094479633369 4449 2867358 SGTC_231 b-estradiol 524 µM -1.55408648329356 0.0657055231875549 no 3103 0.0600818944656662 4531 450 A steroid. SGTC_965 1291-5240 308 µM -1.55998907558036 0.0649561891596853 no 3104 0.0593812314056663 4527 2834598 SGTC_2459 5811157 9.22 µM -1.56130222900229 0.0647903898911977 no 3105 0.0592262289655016 4478 2870684 YBR192W RIM2 SGTC_2333 9017922 200 µM -1.56133603767923 0.0647861255374619 no 3106 0.0592222424392721 4528 3163164 SGTC_1731 st035964 63 µM -1.56346214123903 0.0645183935214224 no 3107 0.0589719668795666 4444 6739575 SGTC_1018 4259-0013 28.1 µM -1.56584855895038 0.0642189058399564 no 3108 0.058692037520275 4561 6801262 SGTC_2222 6885208 172.143 µM -1.56752866429084 0.0640087070291409 no 3109 0.0584955857793157 4553 609514 SGTC_1572 epiandrosterone 68.9 µM -1.56951014870567 0.0637614904944128 no 3110 0.0582645582937298 4475 441302 A steroid. SGTC_900 1112-0045 141 µM -1.56985533245084 0.0637185002966779 no 3111 0.0582243856447272 4433 56211 YIL048W NEO1 SGTC_2260 7964312 200 µM -1.57145338617341 0.0635197677752114 no 3112 0.0580386868813543 4550 231951 SGTC_2446 5162541 200 µM -1.57677762236054 0.062861129958634 no 3113 0.0574233511994084 4505 1549321 SGTC_1208 2323-2347 50.3 µM -1.57811741045557 0.062696231538965 no 3114 0.0572693195669324 4549 5412760 SGTC_42 0133-0086 60.653 µM -1.57813959850112 0.0626935035195248 no 3115 0.0572667714099812 4417 162923 Model of phenazepam hydroxylation. SGTC_3341 9147222 25.867 µM -1.58013564317144 0.0624484681832934 no 3116 0.0570379031077886 4540 1939759 SGTC_1867 st057372 64 µM -1.58082783801103 0.0623636686303257 no 3117 0.0569587037882875 4516 688837 SGTC_269 exalamide 29 µM -1.58162448455078 0.0622661840607732 no 3118 0.0568676605525269 4513 3316 A derivative of salicylamide. SGTC_2033 5192550 145 µM -1.58571592289699 0.0617673917455016 no 3119 0.0564018827402904 4543 182073 SGTC_2325 6158266 200 µM -1.58670059850534 0.0616478156504856 no 3120 0.0562902353660543 4513 3623240 SGTC_1329 1447-1697 50.6 µM -1.58824450752669 0.0614606918791723 no 3121 0.0561155301857406 4530 2840515 SGTC_1111 tnp00062 510.699 nM -1.588281779612 0.0614561799446536 no 3122 0.0561113178545401 4540 676306 SGTC_2064 5220758 200 µM -1.58944573545411 0.0613154086015482 no 3123 0.055979897996129 4562 788518 SGTC_362 0310-0100 9.03 µM -1.59484505339274 0.0606656956379953 no 3124 0.0553734446697893 4558 790235 SGTC_2253 7938677 135.83 µM -1.59505428174827 0.0606406274838788 no 3125 0.0553500488932969 4583 2301972 SGTC_2525 harmine 47.85 µM -1.60450232826489 0.0595170556206025 no 3126 0.0543016858344406 4565 5280953 A monoamine oxidase inhibitor SGTC_179 1273-0063 6.77 µM -1.60841253970319 0.0590568502820948 no 3127 0.05387242855505 4528 3108139 SGTC_3177 9107506 49.47 µM -1.6094958235898 0.058929850156954 no 3128 0.0537539837457659 4529 8897194 SGTC_2425 5628681 7.85 µM -1.6108333677289 0.0587733372610782 no 3129 0.0536080230975845 4587 5714958 SGTC_274 sirtinol 40.1 µM -1.61408692391698 0.0583939839225318 no 3130 0.0532542866277496 4588 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_1825 st052143 62.6 µM -1.61595286803793 0.0581772905788793 no 3131 0.0530522519200422 4602 674173 SGTC_664 1222-0054 14.9 µM -1.61780130239173 0.0579632540647868 no 3132 0.0528527128201057 4527 6813991 SGTC_141 0443-0274 32.331 µM -1.61826625282988 0.0579095134066871 no 3133 0.0528026150927997 4488 1627241 SGTC_1809 st050081 57.6 µM -1.61964115893066 0.0577508259000611 no 3134 0.0526546913690249 4606 5036894 SGTC_2748 diazoxide 86.69 µM -1.6290927427041 0.0566691885837469 no 3135 0.0516466936639988 4636 3019 A potassium channel activatior. SGTC_496 calpeptin 138 µM -1.62944546405918 0.0566291342603277 no 3136 0.0516093754711156 4546 73364 A calpain inhibitor. SGTC_1528 arabinosylhypoxanthine 74.6 µM -1.63133568078788 0.0564148649891397 no 3137 0.0514097542299109 4586 804 An inhibitor of viral and cellular DNA polymerases. SGTC_1879 gemcitabine 100 µM -1.63189242704334 0.0563518758830618 no 3138 0.0513510748222871 4535 60750 A nucleoside analog which inhibits DNA replication. SGTC_1615 st002656 86.5 µM -1.63617453353331 0.055869258479127 no 3139 0.050901532333744 4565 1584458 SGTC_3344 9148862 3.898 µM -1.6376338790526 0.0557055291138231 no 3140 0.0507490456511052 4593 4905352 SGTC_2226 7298446 200 µM -1.64007501861501 0.0554324953819098 no 3141 0.0504947849364634 4583 3283010 SGTC_677 0929-0063 136 µM -1.642190441248 0.0551967475804769 no 3142 0.0502752715181547 4594 1539583 SGTC_2545 solidagenone 89.61 µM -1.64334745523244 0.0550681425859543 no 3143 0.0501555325070442 4519 6708572 An anti ulcer agent SGTC_2344 7990960 76.95 µM -1.64359199612528 0.0550409915845241 no 3144 0.0501302541734982 4550 140813 SGTC_1313 1220-0047 237 µM -1.64801536630839 0.0545516953000235 no 3145 0.0496747589863127 4562 3528706 SGTC_2477 5967686 25.23 µM -1.65340150814006 0.0539605524293806 no 3146 0.0491245880706041 4566 776118 SGTC_1147 3809-1045 12.3 µM -1.65366761919672 0.0539314780450636 no 3147 0.0490975326622846 4586 325925 SGTC_2862 9027634 71.43 µM -1.65912298562947 0.0533381723066518 no 3148 0.0485455061913015 4532 5012562 SGTC_3163 9099914 49.47 µM -1.65963602159326 0.0532826435522183 no 3149 0.0484938485946015 4659 16268368 SGTC_2418 pentamidine 31.67 µM -1.6624093787941 0.052983260523681 no 3150 0.0482153598410248 4520 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2383 9036125 200 µM -1.66591670139196 0.0526065583204394 no 3151 0.0478650033105598 4537 79580 SGTC_970 1315-0089 19.5 µM -1.66852800949601 0.0523274749303893 no 3152 0.0476054782305853 4559 6811083 YLR033W RSC58 SGTC_95 0471-0001 561.058 µM -1.67294801809012 0.0518577671152833 no 3153 0.0471687648548793 4562 4015405 SGTC_3169 9102970 49.47 µM -1.67494144168144 0.0516470281873367 no 3154 0.0469728607805005 4635 17027839 SGTC_1100 amiodarone 5.07 µM -1.67855441590329 0.0512668108688553 no 3155 0.0466194584197425 4611 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_2086 5274770 176.623 µM -1.6788240169906 0.0512385284733011 no 3156 0.0465931732171525 4610 689278 SGTC_2322 7413319 38.22 µM -1.68169690181317 0.050937919959944 no 3157 0.0463138145625423 4520 1840400 SGTC_524 r073-0010 27.8 µM -1.68332194503265 0.0507685038554975 no 3158 0.0461563922033359 4528 2772106 SGTC_2133 5320837 200 µM -1.69006223518002 0.0500705913961925 no 3159 0.0455080244166858 4597 2841355 SGTC_122 0236-0016 402.397 µM -1.69354422677029 0.0497130625501836 no 3160 0.0451759619756996 4569 6808838 SGTC_2897 9048598 12.99 µM -1.69783653171367 0.0492751374797389 no 3161 0.044769309429584 4569 6467404 SGTC_2638 epoxomicin 18 µM -1.71005163453101 0.0480457238195185 no 3162 0.0436281626508015 4559 9915668 A protesome inhibitor. SGTC_2707 st078556 66.6 µM -1.71290019110344 0.0477625844313653 no 3163 0.0433654515642558 4514 17250899 SGTC_508 roscovitine 141 µM -1.71414698886952 0.0476390769698405 no 3164 0.0432508669199282 4659 160355 A CDKinase inhibitor. SGTC_88 0180-0332 8.668 µM -1.7184773652193 0.0472120968931732 no 3165 0.0428547897853561 4655 3101745 SGTC_3062 9077494 49.47 µM -1.71863799053063 0.0471963182477312 no 3166 0.0428401547897971 4526 16459633 SGTC_2596 sinensetin 100 µM -1.71899935763295 0.0471608356618926 no 3167 0.042807244446121 4585 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_1211 1056-0033 32.3 µM -1.72580626584961 0.0464964528389321 no 3168 0.0421911361026385 4626 6741922 SGTC_78 0336-0123 156.75 µM -1.7336703420047 0.0457382614433173 no 3169 0.0414882958386152 4475 6765896 SGTC_2569 tetrandrine 100 µM -1.73418516311551 0.0456889751170471 no 3170 0.041442617314936 4594 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1102 cgs 12066b 26.1 µM -1.7356006162969 0.0455536869293062 no 3171 0.0413172384599396 4616 6438352 A 5-HT1B full agonist. SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -1.74034433304661 0.0451026323774617 no 3172 0.0408992869454417 4545 5711223 A potent inhibitor of glutathione S-transferases. SGTC_2508 celastrol 40.54 µM -1.74065052048411 0.0450736425772713 no 3173 0.0408724281516275 4550 122724 Celastrol is a natural product and antioxidant. SGTC_2271 7849410 118.62 µM -1.753640016566 0.0438575477832853 no 3174 0.0397461048202893 4551 972430 SGTC_3202 9113761 49.47 µM -1.7555702607515 0.0436791155018192 no 3175 0.0395809069468989 4545 4798415 SGTC_2600 tangeritin 87.95 µM -1.75826609714941 0.0434308925060299 no 3176 0.0393511217049986 4536 68077 A bioactive flavone. SGTC_2307 7538926 6.34 µM -1.75846811885412 0.0434123370281402 no 3177 0.0393339457718613 4560 96582 SGTC_2240 6690706 185.951 µM -1.76331954870092 0.0429686574776675 no 3178 0.0389233050261208 4510 805876 SGTC_2078 5212016 200 µM -1.76414736861251 0.0428933177696609 no 3179 0.038853585578129 4528 1899708 SGTC_2906 7926292 26.41 µM -1.76997123897555 0.0423663011762434 no 3180 0.0383659660212088 4601 2966319 SGTC_426 0988-0037 14.6 µM -1.77291240699988 0.0421021450287737 no 3181 0.0381216112279434 4609 5383008 SGTC_819 1013-0258 27.7 µM -1.77301666578352 0.0420928057177022 no 3182 0.038112972667472 4621 5753198 SGTC_2543 pimpinellin 60.67 µM -1.77420402322238 0.0419865626502305 no 3183 0.0380147044903032 4487 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_2840 9008771 71.43 µM -1.7815745987717 0.0413319010196136 no 3184 0.0374093148812561 4575 2992978 SGTC_2171 5739187 198.077 µM -1.78198187858648 0.0412959686205165 no 3185 0.037376093453212 4587 2262761 SGTC_3094 9117742 49.47 µM -1.78447473478702 0.041076586999173 no 3186 0.0371732783312303 4591 17149698 SGTC_1626 st003712 1.76 µM -1.78974343240137 0.0406160293009256 no 3187 0.0367475833663856 4620 24207035 SGTC_75 0159-0059 199.013 µM -1.79484270887988 0.0401742813871748 no 3188 0.0363393820072874 4629 5377270 SGTC_2517 totarol 10 µM -1.79960010811162 0.039765677067774 no 3189 0.0359619020053797 4633 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_2244 6635614 200 µM -1.8007857176701 0.0396643749043534 no 3190 0.0358683304302473 4574 836499 SGTC_2975 9084847 53.72 µM -1.80638378928057 0.0391888893300616 no 3191 0.0354292059665727 4602 27211724 SGTC_31 0508-1974 57.237 µM -1.8125566149581 0.0386699747043576 no 3192 0.034950117220582 4587 6810525 SGTC_748 act1.228 77.9 µM -1.81267566032853 0.0386600225234971 no 3193 0.0349409303300882 4612 4421505 YNR035C ARC35 SGTC_1986 st071812 45 µM -1.81505001248393 0.0384619624405284 no 3194 0.0347581120393662 4591 11838594 SGTC_1744 st037937 38.9 µM -1.81655733547842 0.038336656604948 no 3195 0.0346424606157665 4645 1016152 SGTC_2054 5233173 129 µM -1.83797119558832 0.0365921784331693 no 3196 0.0330333249423828 4629 6889 SGTC_1668 st014914 51.6 µM -1.84008562559034 0.0364235070149592 no 3197 0.0328778336526273 4657 2839556 SGTC_36 0335-0881 14.2 µM -1.84080982603123 0.0363658828935029 no 3198 0.0328247161861676 4556 23828853 SGTC_2386 9075165 157.42 µM -1.84969791622644 0.0356647225135093 no 3199 0.0321785505086295 4630 16452277 SGTC_2346 9031566 143.75 µM -1.85371197642606 0.0353517149355175 no 3200 0.0318901886860726 4644 4771086 SGTC_1158 4092-0494 91.8 µM -1.86450402773724 0.0345213319061941 no 3201 0.0311254782422393 4683 1148199 SGTC_743 1275-0778 158 µM -1.86811337747847 0.0342472159103628 no 3202 0.0308731346460027 4627 2849257 YMR203W TOM40 SGTC_2024 5144227 134 µM -1.87031342534563 0.0340810102796555 no 3203 0.0307201531463674 4615 3475211 SGTC_2937 9044753 11.33 µM -1.87042313018662 0.0340727398681831 no 3204 0.0307125412204541 4584 6465530 YGL099W LSG1 SGTC_1974 st069448 26.9 µM -1.87055328400779 0.0340629299925915 no 3205 0.0307035124572495 4641 6323587 YNR016C ACC1 SGTC_902 1120-0002 2.07 µM -1.87095235279163 0.0340328660962236 no 3206 0.0306758427774335 4637 3280475 SGTC_2272 7805186 180 µM -1.88408809032167 0.0330553994685597 no 3207 0.0297765304596303 4657 2956062 YPR165W RHO1 SGTC_2193 5925765 200 µM -1.8851075837005 0.0329805134825725 no 3208 0.0297076571882563 4670 877370 SGTC_3023 9089636 49.47 µM -1.8952120217082 0.0322458341986019 no 3209 0.0290321590613324 4714 17249241 SGTC_235 0330-0087 5 mM -1.90247533025113 0.0317261169262517 no 3210 0.0285545205148374 4685 46494818 YHR062C RPP1 SGTC_2011 4012611 177 µM -1.90616250268429 0.0314649458484555 no 3211 0.0283145627682896 4627 2049887 SGTC_1210 3013-0140 750 nM -1.90825689422597 0.0313173883929346 no 3212 0.0281790106926554 4682 905973 SGTC_2967 9089538 49.85 µM -1.91648580082442 0.0307431627337991 no 3213 0.0276516444273854 4646 728216 SGTC_3065 9113888 49.47 µM -1.92959897625254 0.0298461374587702 no 3214 0.0268282728868382 4667 16648368 SGTC_781 4335-2806 94.4 µM -1.93161029402493 0.0297104901385364 no 3215 0.0267038121633336 4686 845254 SGTC_1627 st003713 25.6 µM -1.93861097665555 0.0292423330734368 no 3216 0.0262743629759558 4658 16195070 YER133W GLC7 SGTC_3203 9113543 49.47 µM -1.94479588520061 0.0288338426680781 no 3217 0.0258997747818643 4660 17018012 SGTC_400 oxethazaine 37.5 µM -1.94759111335839 0.0286507906524852 no 3218 0.0257319539691909 4691 4621 A local anesthetic. SGTC_578 3460-0051 92 µM -1.94836886690747 0.0286000298630008 no 3219 0.0256854211331274 4711 2876744 SGTC_3153 9100258 49.47 µM -1.94872545624305 0.0285767817589947 no 3220 0.025664110028938 4594 25236848 SGTC_2112 5488546 200 µM -1.95076278949689 0.0284442575834379 no 3221 0.0255426351015997 4651 600757 SGTC_2364 9055074 200 µM -1.95547926750999 0.0281394219897821 no 3222 0.0252632640545348 4663 6470630 SGTC_1466 k213-0079 57.5 µM -1.9577187569715 0.0279956343708447 no 3223 0.0251315115218867 4675 3657981 SGTC_2886 9058944 51.95 µM -1.95843806809972 0.0279495806508848 no 3224 0.0250893157518155 4659 4949929 SGTC_3188 9110789 49.47 µM -1.96126141638692 0.0277694259521528 no 3225 0.0249242678575912 4645 849217 SGTC_1458 k015-0034 6.33 µM -1.96438034827341 0.0275715362762181 no 3226 0.0247430000399547 4694 3598957 SGTC_3014 9081533 49.47 µM -1.96825713010848 0.0273272026755432 no 3227 0.0245192299290461 4670 21367265 SGTC_1207 2099-0101 141 µM -1.9717131997773 0.0271109095083392 no 3228 0.0243211779703315 4678 5837381 SGTC_307 1501-1223 22.3 µM -1.99012944395503 0.0259823058778073 no 3229 0.0232883390374641 4689 2830329 SGTC_3107 9121808 49.47 µM -1.99107641456903 0.025925351246053 no 3230 0.0232362434824565 4639 662681 SGTC_59 0330-0160 1.33 µM -1.99712144936003 0.025564234974538 no 3231 0.0229059956956408 4638 4293482 SGTC_1213 1315-0166 115 µM -1.99890329341251 0.025458598926003 no 3232 0.0228094091708982 4671 768401 SGTC_3191 9110352 49.47 µM -1.99897385333902 0.0254544233398013 no 3233 0.0228055914786082 4645 17122424 SGTC_2198 6589944 200 µM -2.00060955071012 0.025357786903065 no 3234 0.0227172417705429 4699 5290268 SGTC_58 0957-0393 9 µM -2.00709549851481 0.0249776196217792 no 3235 0.0223697477278565 4208 6997992 SGTC_733 4069-0007 56.1 µM -2.01310932020224 0.0246294063819137 no 3236 0.0220515649744152 4675 5717425 YNL287W SEC21 SGTC_2072 5231554 129 µM -2.01959532984581 0.0242584272538662 no 3237 0.0217126899889873 4732 789545 SGTC_903 1134-0042 114 µM -2.03657156725067 0.0233095956381496 no 3238 0.020846497240852 4702 701009 SGTC_365 0121-0052 13.6 µM -2.04560000779652 0.0228178331925666 no 3239 0.0203978703527184 4657 3101739 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -2.05207631610912 0.0224704898917472 no 3240 0.0200811231238941 4712 4174840 SGTC_750 4073-0104 132 µM -2.05444710384313 0.0223444574847113 no 3241 0.0199662190142642 4409 22330957 SGTC_2932 9016711 44.54 µM -2.05888213609385 0.0221102895408887 no 3242 0.0197527653882014 4670 7117328 SGTC_3090 9117696 49.47 µM -2.0609470974328 0.0220019691045655 no 3243 0.0196540436949563 4689 7923821 SGTC_2259 7964009 200 µM -2.06614504201098 0.0217312852706301 no 3244 0.0194073931599212 4709 313134 SGTC_2877 9040724 71.43 µM -2.06850065359584 0.0216095458444028 no 3245 0.019296484606994 4667 6463895 SGTC_2261 9010538 184.68 µM -2.07235219794866 0.0214117373144962 no 3246 0.0191163039164998 4673 6457250 SGTC_3118 9124250 49.47 µM -2.07291436610184 0.0213829937684759 no 3247 0.0190901249008771 4689 1504786 SGTC_1260 0700-1617 7.75 µM -2.07653377138259 0.0211987144145832 no 3248 0.0189223055188587 4669 2853078 SGTC_3317 9138495 8.753 µM -2.07923104819738 0.0210622596857119 no 3249 0.0187980596055029 4659 17020139 SGTC_3026 9090633 49.47 µM -2.08052608907966 0.020997008341783 no 3250 0.0187386526205041 4703 25236842 SGTC_932 2857-0803 154 µM -2.08406874468929 0.0208193831938543 no 3251 0.0185769572975092 4677 674898 SGTC_2378 9074213 121.43 µM -2.08656948437982 0.0206947660224821 no 3252 0.0184635340609859 4693 657714 SGTC_432 NS 1619 61.3 µM -2.08726176221089 0.0206603801968634 no 3253 0.0184322396196257 4652 4552 A K+/calcium channel activator. SGTC_316 k060-0003 58.6 µM -2.08829803319053 0.0206089984799029 no 3254 0.0183854793866747 4720 6152314 SGTC_34 0469-0683 81.75 µM -2.10458046000782 0.0198157682827764 no 3255 0.0176639220035402 4693 3690923 SGTC_2691 st077356 60.2 µM -2.1157482173221 0.019286818818107 no 3256 0.0171831136604091 4673 2839272 SGTC_334 1502-1024 68.5 µM -2.12391405738828 0.0189076894857206 no 3257 0.016838665350841 4704 3296216 SGTC_2788 5282734 71.43 µM -2.12578236555924 0.0188218431652302 no 3258 0.0167606925081022 4698 743706 SGTC_1364 1653-0028 37.6 µM -2.13517501327102 0.0183952711122629 no 3259 0.0163733585520765 4727 5718652 SGTC_1505 k297-0037 20.6 µM -2.14188003029328 0.0180958208518111 no 3260 0.0161015686051286 4705 4089396 SGTC_1981 st071826 47 µM -2.14884481703096 0.0177891789914116 no 3261 0.01582335169815 4736 11838600 SGTC_504 lovastatin 124 µM -2.15127248975482 0.0176833417582624 no 3262 0.0157273491628474 4703 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_35 0133-0054 64.071 µM -2.15963453716152 0.0173228918767191 no 3263 0.0154004862859878 4666 99677 SGTC_272 doxorubicin 8.13 µM -2.16055891659075 0.0172834340075092 no 3264 0.0153647139345924 4733 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -2.16815407564559 0.0169621260316821 no 3265 0.0150734828205211 4729 7104 SGTC_1958 st076513 41.9 µM -2.17085528625808 0.016849090932586 no 3266 0.0149710566102133 4668 732122 YGL099W LSG1 SGTC_3027 9089541 49.47 µM -2.17379833098112 0.0167266699285315 no 3267 0.0148601419729515 4705 9943819 SGTC_1204 4049-0315 18.3 µM -2.18059676922119 0.0164467832250295 no 3268 0.014606627154265 4692 588402 SGTC_415 dibenzyl ketone 100 µM -2.18201945899229 0.0163887222033783 no 3269 0.0145540483118561 4709 7593 SGTC_1457 k015-0032 57.3 µM -2.19111495649592 0.0160216605193727 no 3270 0.0142217373331575 4725 4302660 SGTC_1168 k815-0004 80.5 µM -2.19457897074086 0.015883729984712 no 3271 0.0140969067042182 4716 642433 SGTC_2648 atorvastatin 78.68 µM -2.19847724070988 0.0157297270343072 no 3272 0.0139575573436894 4735 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_2099 5377090 177.372 µM -2.21044059055893 0.0152650812398059 no 3273 0.0135372996818531 4729 2243829 SGTC_2224 6650123 117.647 µM -2.21416852233763 0.0151227222066977 no 3274 0.0134085941787914 4782 2908370 SGTC_171 k064-0041 9.68 µM -2.22252597069249 0.0148077151080383 no 3275 0.0131238904578548 4702 53325 SGTC_2646 retinol 96.75 µM -2.22376181281453 0.0147616162981622 no 3276 0.013082236964763 4748 445354 A vitamin A analog and teratogen. SGTC_2891 9063876 19.48 µM -2.22543957328153 0.0146992308317106 no 3277 0.0130258717090108 4749 6472478 SGTC_837 0091-0265 12.5 µM -2.22752692885022 0.0146219318184213 no 3278 0.0129560390623765 4734 759367 SGTC_2359 9039622 200 µM -2.23243257418408 0.0144416415695667 no 3279 0.0127931934588621 4708 6463596 SGTC_3151 9099821 49.47 µM -2.246643494815 0.0139301306645979 no 3280 0.012331410055254 4683 17174189 SGTC_480 am 92016 50 µM -2.26304010077292 0.0133594272905351 no 3281 0.0118166087092518 4741 2129 K+ channel blocker. SGTC_2772 vinpocetine 57.06 µM -2.28249960999758 0.0127084191787926 no 3282 0.0112299302409639 4718 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_2852 9023854 51.95 µM -2.28838040711522 0.0125171611183235 no 3283 0.0110576888149938 4723 19798528 SGTC_2247 cerulenin 830 nM -2.3035544495584 0.0120351345512547 no 3284 0.0106238336563332 4750 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_1410 3909-8106 77.9 µM -2.33055962351522 0.011217008587494 no 3285 0.00988829631481789 4770 1039210 SGTC_2367 9070478 135.38 µM -2.34694498948594 0.0107445451671873 no 3286 0.00946402455692264 4719 572802 SGTC_2890 9046729 58.44 µM -2.34756265100491 0.0107270792993614 no 3287 0.00944834744367877 4740 903329 SGTC_620 0109-0052 432 µM -2.35016276696312 0.0106538255567294 no 3288 0.00938260162671301 4753 493037 SGTC_2236 dapsone 200 µM -2.36907940386417 0.0101338766760997 no 3289 0.00891621227208432 4759 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_1163 k060-0048 49.9 µM -2.3692548024341 0.010129161083734 no 3290 0.00891198462320468 4750 6809982 SGTC_3164 9100705 49.47 µM -2.39887941067585 0.00935966960622991 no 3291 0.00822266476669671 4757 17174235 SGTC_1112 tnp00069 1.16933 µM -2.41544588261561 0.00895205691356441 no 3292 0.0078579788588042 4745 145826 SGTC_2974 9094440 9.66 µM -2.41962420005527 0.00885173971015025 no 3293 0.00776827703771513 4722 25236134 SGTC_3271 9137798 49.47 µM -2.43270582172534 0.00854400611109643 no 3294 0.00749323565323665 4757 6498326 SGTC_744 1594-0068 283 µM -2.43577760125484 0.00847312083638032 no 3295 0.00742990880561425 4753 668392 SGTC_1124 fisetin 1.16336 µM -2.46490368457846 0.00782623943945204 no 3296 0.00685250429018203 4749 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_1175 0741-0056 27.6 µM -2.46619466384766 0.00779860095411862 no 3297 0.00682785490922081 4766 765927 SGTC_1062 mesoridazine 14.2 µM -2.46923737330944 0.00773379928359537 no 3298 0.00677006836649621 4789 4078 A neuroleptic. SGTC_1987 st072290 61.9 µM -2.48280749964131 0.00745052660213112 no 3299 0.00651757541270989 4766 54697379 SGTC_3187 9109394 49.47 µM -2.4964026907242 0.00717593787759787 no 3300 0.00627300429284908 4758 17098090 SGTC_2812 7970281 58.44 µM -2.4988595746437 0.00712727870905047 no 3301 0.00622968356284715 4759 2233435 SGTC_1504 k297-0033 30 µM -2.51943442022595 0.00673108450311018 no 3302 0.00587717670876172 4725 4388117 SGTC_3283 9109332 35.8195 µM -2.53410268848143 0.00646063803388085 no 3303 0.00563678447617197 4673 17027281 SGTC_1170 0310-0127 64.8 µM -2.5362420450391 0.00642200764881408 no 3304 0.00560246292654229 4760 774975 SGTC_624 k048-0052 28 µM -2.55280823632983 0.00612972671248559 no 3305 0.00534291556429913 4775 6835531 SGTC_1148 3909-7663 27.7 µM -2.55320073344912 0.00612294709876316 no 3306 0.00533689804709259 4771 4084526 SGTC_1984 st072354 53.1 µM -2.55364455449025 0.00611528896973117 no 3307 0.00533010092477929 4725 5762938 SGTC_2639 lactacystin 53 µM -2.56088998247606 0.00599146378368337 no 3308 0.00522022062726865 4761 3870 A proteasome inhibitor. SGTC_1216 1165-0504 9.65 µM -2.56768104550849 0.00587742708543435 no 3309 0.00511906554077721 4779 6304004 SGTC_1961 st076550 68.7 µM -2.59205978535882 0.00548375424475669 no 3310 0.00477015953990821 4774 1579337 SGTC_3204 9114183 49.47 µM -2.59640251246511 0.00541613973162465 no 3311 0.00471028172080687 4727 17027248 SGTC_2568 diosmetin 100 µM -2.59903371169588 0.00537553447156899 no 3312 0.00467432958716915 4767 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_3215 9129942 49.47 µM -2.60687486849882 0.00525612838400043 no 3313 0.0045686372496141 4752 17682944 SGTC_2873 9040596 71.43 µM -2.61544172101777 0.00512837365677648 no 3314 0.00445560636291757 4751 6463863 SGTC_3284 9108171 64.8615 µM -2.63101110418004 0.00490325199960597 no 3315 0.00425656272054172 4750 8687505 SGTC_3224 9130643 49.47 µM -2.63269564292252 0.00487943068851931 no 3316 0.00423551098217239 4764 17644395 SGTC_170 4197-0004 226 µM -2.63998392091845 0.00477755034683002 no 3317 0.00414549803692001 4754 218692 SGTC_3083 9117465 49.47 µM -2.64790073423997 0.0046690370609747 no 3318 0.00404966517616053 4743 16420915 SGTC_8 0354-0001 70 µM -2.65779299050824 0.00453654057649761 no 3319 0.0039327094585328 4771 4993152 SGTC_1709 st033179 39.1045 µM -2.65964798492686 0.00451207199151594 no 3320 0.00391111790955265 4784 573381 SGTC_1999 st074831 12.5 µM -2.6737274980068 0.00433016332390823 no 3321 0.00375066889366776 4759 17112523 SGTC_1570 verbenone 133 µM -2.70717495082622 0.00392403903977418 no 3322 0.00339292431930603 4772 29025 A natural terpanoid with antifungal properties. SGTC_625 k213-0058 121 µM -2.72984172550373 0.00366856450251891 no 3323 0.00316823695850689 4795 3655420 SGTC_2022 5136654 200 µM -2.73399946077876 0.00362335688130983 no 3324 0.0031285073443318 4761 1713771 SGTC_3031 9088762 49.47 µM -2.76343386621343 0.00331735395789771 no 3325 0.00285983409207445 4776 205253 SGTC_2697 mebhydrolin 72.4 µM -2.76994366761225 0.0032528987170497 no 3326 0.00280329942208621 4770 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_2382 9035899 200 µM -2.84801175792409 0.00256310893714517 no 3327 0.00219966495852492 4789 6462679 SGTC_354 2783-3500 4.88 µM -2.87861322510871 0.00233095035768623 no 3328 0.00199713935056554 4777 6740761 SGTC_1465 k213-0056 144 µM -2.94084309494209 0.00191658533252946 no 3329 0.00163660144348427 4753 24048857 YMR208W ERG12 SGTC_61 0978-8327 98.565 µM -2.94745882621085 0.00187672298153026 no 3330 0.00160198708334893 4762 6150059 YHR072W ERG7 SGTC_2959 9079155 11 µM -3.04197989829236 0.00138379435822783 no 3331 0.00117513794647737 4780 16189457 SGTC_3084 9116877 49.47 µM -3.04698087998255 0.00136135204377427 no 3332 0.00115576206298494 4783 27241325 SGTC_3179 9107801 49.47 µM -3.05283378838955 0.00133550925284818 no 3333 0.00113345730711874 4793 4818259 SGTC_879 0831-1030 162 µM -3.14800638880599 0.000973571212410961 yes 3334 0.000821940502188582 4797 1549252 SGTC_835 0312-0010 67.2 µM -3.1704301279651 0.000902594268227908 yes 3335 0.000761067177101236 4801 1626196 SGTC_2640 pentamidine 10.38 µM -3.19969873216363 0.000817103979467585 yes 3336 0.000687856533327 4786 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1979 st071809 45.3 µM -3.2084193363405 0.00079311195805351 yes 3337 0.00066733371243817 4801 4976333 SGTC_741 4582-0002 126 µM -3.2259879945817 0.000746734968038993 yes 3338 0.000627693113678967 4799 2912688 SGTC_2000 st075254 36.4 µM -3.23964890583967 0.000712414640365644 yes 3339 0.000598384799670506 4796 17234175 SGTC_1025 k007-0731 70 µM -3.24356031710662 0.000702859248767573 yes 3340 0.000590229069040682 4790 6256118 SGTC_619 1652-1634 108 µM -3.26196794019602 0.00065945685088419 yes 3341 0.000553208279322998 4790 5400454 SGTC_356 1634-0012 32.5 µM -3.2729408557198 0.000634774996403013 yes 3342 0.000532173732358533 4797 735457 SGTC_2135 5326629 150.42 µM -3.30587057258139 0.000565732609074137 yes 3343 0.000473409057993443 4787 5020077 SGTC_2888 9058547 12.99 µM -3.32472554542396 0.000529394746717815 yes 3344 0.000442528066955736 4786 16476514 SGTC_2214 7179297 48.276 µM -3.34742038118692 0.000488523544064783 yes 3345 0.000407837073297572 4787 769744 SGTC_843 0310-0051 143 µM -3.38544040679949 0.000426540841907928 yes 3346 0.000355320690096124 4800 2065037 SGTC_2366 9070441 60.58 µM -3.44906486445256 0.000338876292659699 yes 3347 0.000281265778329618 4790 6837235 SGTC_2815 7968870 71.43 µM -3.46586362753149 0.000318702242830011 yes 3348 0.000264265643203615 4782 2977326 YHR190W ERG9 SGTC_873 0591-4978 488 µM -3.54945641029201 0.000233902341906112 yes 3349 0.000193013684888551 4803 3305145 SGTC_947 3447-0010 211 µM -3.56932483675609 0.000217111852133962 yes 3350 0.000178951212336641 4791 748350 SGTC_2894 9048625 32.47 µM -3.67141392743619 0.000147203048212475 yes 3351 0.000120606157048182 4802 4092861 SGTC_3216 9129716 49.47 µM -3.81880205989002 8.25565026989295e-05 yes 3352 6.70506547713787e-05 4781 8056934 SGTC_1985 st071382 65.5 µM -3.82186859454354 8.15513436422469e-05 yes 3353 6.62221318587753e-05 4805 6123237 SGTC_1126 isoteolin 1.0172 µM -4.14386084344074 2.14439595950606e-05 yes 3354 1.70753510990799e-05 4801 133323 SGTC_2834 9001755 58.44 µM -4.39332398416612 7.11977915808626e-06 yes 3355 5.58152876457459e-06 4780 2989575 SGTC_343 4130-2827 29.8 µM -4.6797410203543 1.86597131772005e-06 yes 3356 1.43618756510632e-06 4808 1118244