SGTCid condition conc unit CDC15|YAR019C.score CDC15|YAR019C.strain.pval CDC15|YAR019C.strain.significant CDC15|YAR019C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_2158 5657123 3.6195 µM 8.90451150846108 4.03098974930475e-20 yes 1 2.68108242978052e-19 1 2858827
SGTC_2980 9014342 25.29 µM 8.2660818229508 1.36461266597593e-17 yes 2 6.92167787751795e-17 4 2996599
SGTC_2791 5663188 71.43 µM 8.11548147246315 5.06898592037778e-17 yes 3 2.4193126623563e-16 4 54690634
SGTC_2983 9022671 12.99 µM 6.88224737821048 9.7216793624623e-13 yes 4 2.94577925011957e-12 3 6405161
SGTC_2814 7977482 42.97 µM 5.10908478418223 8.94821906452597e-08 yes 5 1.61861536207769e-07 5 6456762
SGTC_2884 9058502 51.95 µM 4.4777818187798 2.40939146779119e-06 yes 6 3.77113129548791e-06 2 6471554
SGTC_2986 9022445 71.43 µM 4.42819082172217 3.06770331266854e-06 yes 7 4.75134064032496e-06 3 6459286
SGTC_2160 5660466 132.927 µM 3.96374953151548 2.61211392381288e-05 yes 8 3.68908322100687e-05 15 2859134
SGTC_1368 1852-0141 284 µM 3.84744128816971 4.31702434260947e-05 yes 9 5.9678934092734e-05 3 2838987
SGTC_2977 9011197 71.43 µM 3.80034280832271 5.27067745670558e-05 yes 10 7.22480272497154e-05 11 2704722
SGTC_57 miconazole 162.5 nM 3.74828979621554 6.55459552661993e-05 yes 11 8.90222331488063e-05 27 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_58 0957-0393 9 µM 3.64093278746091 0.000101884069912607 yes 12 0.000135826026555463 56 6997992
SGTC_1713 st033146 12.748 µM 3.59631554826038 0.000121969075092451 yes 13 0.000161378126491318 12 674619
SGTC_3138 9097216 49.47 µM 3.52084543070065 0.000164615271054079 yes 14 0.000215086645919233 9 25237486
SGTC_2703 st077852 53.4 µM 3.43501393188557 0.000229921928042783 yes 15 0.000296261682930498 9 6281836
SGTC_2902 5787006 60.46 µM 3.397003367721 0.00026596731556391 yes 16 0.000340640642540041 9 591003
SGTC_1133 3473-0247 50 µM 3.32872704107353 0.000344251510762132 yes 17 0.000436219315744174 62 711311
SGTC_232 clozapine 119 µM 3.27487288195587 0.000420574008112225 yes 18 0.000528547644000924 8 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_3142 9086498 49.47 µM 3.15062558266783 0.000660299200483322 yes 19 0.000814605994508544 61 25236367
SGTC_305 1682-2595 20.8 µM 3.07679659603189 0.000857075187160698 yes 20 0.00104619013057303 16 226033
SGTC_1799 st045822 46.1415 µM 3.07046601473855 0.000876241591954114 yes 21 0.00106862504026138 7 3674992
SGTC_1912 st060209 90.8 µM 3.06117064739702 0.000905099038992619 yes 22 0.00110236699818739 24 688787
SGTC_417 st075190 100 µM 3.04664045604418 0.000951961897135871 yes 23 0.00115707166803322 8 222757
SGTC_3073 9114972 49.47 µM 3.0430683341176 0.000963819002382067 yes 24 0.00117089574522672 14 41905075
SGTC_2970 9090938 41.86 µM 3.03139119114227 0.00100353207014681 no 25 0.0012171481980972 19 17217104
SGTC_2453 5731132 22.18 µM 3.01386881902615 0.00106594793395774 no 26 0.00128969654745603 17 1362040
SGTC_2443 5493264 126.67 µM 2.98077691601819 0.00119362711380075 no 27 0.00143759078903476 13 5340055
SGTC_2973 9094665 17.96 µM 2.97924503428799 0.00119986348293671 no 28 0.00144479799734224 33 25237061 YIL048W NEO1
SGTC_781 4335-2806 94.4 µM 2.96942751351405 0.00124054435793359 no 29 0.00149177596628585 10 845254
SGTC_2292 7671323 168.05 µM 2.92569909270124 0.00143751624514676 no 30 0.00171841592915376 27 937504
SGTC_608 k048-0125 159 µM 2.91391342291491 0.00149528268085838 no 31 0.00178464439546394 14 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_2787 5284540 71.43 µM 2.88166873027758 0.00166431476583686 no 32 0.00197787688342123 24 736958
SGTC_3016 9080866 49.47 µM 2.84635647934694 0.0018692494590814 no 33 0.00221113293129514 15 17066299
SGTC_1237 0330-0133 46.1 µM 2.82258990799726 0.00201982088122397 no 34 0.00238187314349076 22 X1237 YHR072W ERG7
SGTC_682 0kpi-0099 17 µM 2.79724915792446 0.00219242114734836 no 35 0.00257698853195594 66 1714895 YML126C ERG13
SGTC_523 1934-0222 13.7 µM 2.77024409419858 0.00239097756063722 no 36 0.00280071486318273 23 1361595
SGTC_2420 aureobasidin a 50 nM 2.75955407645408 0.00247397287715641 no 37 0.00289401534696094 15 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_621 3584-0052 32.1 µM 2.73535193623815 0.00267157915407158 no 38 0.00311568065327711 22 2273927
SGTC_427 1354-0053 47.3 µM 2.7303897880555 0.00271381365673381 no 39 0.00316297404405902 15 6813657
SGTC_3317 9138495 8.753 µM 2.71311261439201 0.0028656095877719 no 40 0.00333272252714272 27 17020139
SGTC_1774 st048371 48.465 µM 2.69185813474814 0.00306283120497433 no 41 0.00355275815317638 28 4242727
SGTC_728 3030-5151 22.5 µM 2.67726545992647 0.00320522905945051 no 42 0.00371128999580524 10 3125388
SGTC_1882 5615643 20 µM 2.6707388586075 0.00327082321849852 no 43 0.00378422511178272 23 2253075
SGTC_622 1348-1566 26.3 µM 2.66381865650145 0.00334168960023668 no 44 0.00386295996635104 23 7340407
SGTC_1016 4226-1401 38 µM 2.65727891523684 0.00340992527014019 no 45 0.00393871199761622 36 2901613
SGTC_1006 4099-6547 255 µM 2.65579942228851 0.00342553490821575 no 46 0.00395603294407781 20 3146833
SGTC_3191 9110352 49.47 µM 2.65442365333865 0.00344010776712718 no 47 0.00397220074060031 11 17122424
SGTC_139 0099-0334 718.624 µM 2.6414293140631 0.00358052244774323 no 48 0.0041278516173973 23 97690
SGTC_1338 1486-1223 76 µM 2.63306860054055 0.00367356564513376 no 49 0.00423086272588974 18 3444526
SGTC_780 0109-0199 192 µM 2.61202024119384 0.00391748042096138 no 50 0.0045004462430067 28 610414
SGTC_3236 9132701 49.47 µM 2.60601327887288 0.00398970279726977 no 51 0.00458014551350697 21 24282524
SGTC_3050 9093513 49.47 µM 2.60208133698664 0.00403762034794386 no 52 0.00463299366320674 24 25236664
SGTC_1161 k007-0610 110 µM 2.57993331185656 0.00431728253435103 no 53 0.00494096982100405 59 5843850
SGTC_234 nsc-17383 10.7 µM 2.53848598206676 0.00488751482949453 no 54 0.00556666314673272 29 408974
SGTC_330 1488-0319 80.1 µM 2.49545129941875 0.00554970356172435 no 55 0.00628985110294273 30 6846614
SGTC_3204 9114183 49.47 µM 2.47240603897885 0.00593611491363217 no 56 0.00671034940968828 38 17027248
SGTC_1010 4112-3296 15.2 µM 2.46628413919204 0.00604269444497497 no 57 0.00682614941287331 28 704384
SGTC_418 lividomycin a 100 µM 2.44935162041603 0.00634636630421989 no 58 0.00715568309131233 21 72394 An antibiotic.
SGTC_2192 5915882 198.485 µM 2.44372816022437 0.00645016563920393 no 59 0.00726818742745179 49 2876149
SGTC_1138 3761-0006 1.03 µM 2.44325877746754 0.00645889717358462 no 60 0.00727764816073858 8 12061087
SGTC_634 1611-4317 11.2 µM 2.43006222083014 0.00670869978628407 no 61 0.007548115490044 31 2843522
SGTC_2025 5147754 141 µM 2.42982140953996 0.00671333644198812 no 62 0.00755313216053329 22 315777 YLR208W SEC13
SGTC_1903 st060211 78.3 µM 2.42830394533078 0.00674261937542105 no 63 0.00758481214665226 24 688960
SGTC_753 1322-0200 289 µM 2.42288689876474 0.00684807632448376 no 64 0.00769885985942592 13 5403907
SGTC_793 0488-0545 106 µM 2.40037831646167 0.00730202785808506 no 65 0.00818906755038856 31 292548
SGTC_3290 9121031 71.43 µM 2.37934214753348 0.00775005635559268 no 66 0.00867178473114262 18 17014854
SGTC_1977 st070720 65.3 µM 2.36944116252424 0.00796917569059967 no 67 0.00890749469229931 9 682188
SGTC_2186 6124449 200 µM 2.35514989941261 0.00829505889186273 no 68 0.00925761751542204 48 3834182 YLR033W RSC58
SGTC_300 r073-0011 5.04 µM 2.35086804413626 0.00839494977545039 no 69 0.00936483732176978 26 2735780
SGTC_2784 7567673 72.73 µM 2.34852913152511 0.00844995870105479 no 70 0.00942386238621225 39 3471247
SGTC_2439 5492030 7.2 µM 2.34548036929543 0.00852213739781637 no 71 0.00950128961598187 28 5722370
SGTC_1872 amphotericin b 148 nM 2.33739432937732 0.00871619872487506 no 72 0.00970934485872203 40 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_839 0122-0028 230 µM 2.32581029429152 0.00900095894336936 no 73 0.0100143366140328 82 759448
SGTC_791 1348-1292 225 µM 2.31664566439371 0.00923198618166848 no 74 0.0102615208453963 26 5437054
SGTC_1432 4049-0298 68.4 µM 2.3147794097328 0.00927966272378533 no 75 0.0103125036631442 24 741646
SGTC_806 3966-4455 5.86 µM 2.29889542339728 0.00969424106564065 no 76 0.010755439177843 37 714982
SGTC_1202 1988-0068 29.6 µM 2.2769990644768 0.0102922328340518 no 77 0.0113931407427606 36 2850480
SGTC_266 formosanin C 406 nM 2.26404598498233 0.0106609199325897 no 78 0.0117856433129958 57 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_3033 9090887 49.47 µM 2.26176947864515 0.0107268916510006 no 79 0.0118558247533582 58 19325384
SGTC_489 paxilline 115 µM 2.25614575241593 0.0108913894353773 no 80 0.0120307523005805 29 105008 A toxic potassium channel blocker.
SGTC_256 clotrimazole 625 nM 2.23778563845458 0.0114438120558902 no 81 0.0126175187015292 59 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_2481 5478948 45.16 µM 2.23686987373903 0.0114719919422271 no 82 0.0126474230329531 40 77792
SGTC_2955 9076254 12.21 µM 2.23214914867611 0.0116182161691811 no 83 0.0128025534988741 36 16459619
SGTC_517 1365-0151 113 µM 2.22800715751238 0.0117478442196568 no 84 0.0129400188551745 39 768657
SGTC_3259 9138485 49.47 µM 2.21336249581653 0.0122162804565622 no 85 0.0134363320689526 31 17646153
SGTC_2729 fluphenazine 10.66 µM 2.21261756915385 0.0122405349511681 no 86 0.0134620113604595 42 3372 An atypical antipsychotic.
SGTC_580 1123-0028 41 µM 2.20378114290468 0.012531443634348 no 87 0.0137698696822455 65 1677248 YPR107C YTH1
SGTC_281 1672-3440 14.9 µM 2.19972118932323 0.0126670981602541 no 88 0.013913341242625 30 6833000
SGTC_2808 7946468 45.46 µM 2.1932480169932 0.0128860136079557 no 89 0.0141447573496613 52 2970879
SGTC_2358 9037157 4 µM 2.18597579615811 0.0131358475424913 no 90 0.0144086880791605 63 2388925
SGTC_959 1222-0044 107 µM 2.18584865523096 0.013140252385901 no 91 0.0144133398662862 31 6083612
SGTC_3018 9082602 49.47 µM 2.17883257457282 0.0133853139861784 no 92 0.0146720540552003 41 17332089
SGTC_655 k060-0012 42 µM 2.15703461137872 0.014172025604568 no 93 0.015501483871271 57 5994525
SGTC_2030 5175110 200 µM 2.14364940875339 0.0146745971602765 no 94 0.0160304943466113 33 2831986
SGTC_3202 9113761 49.47 µM 2.14265401830996 0.0147125759603342 no 95 0.0160704450806975 55 4798415
SGTC_1373 2887-0003 58.5 µM 2.1378530240969 0.0148969459983371 no 96 0.016264336952401 64 776948
SGTC_117 lucigenin 22.078 µM 2.13563282465955 0.0149828766845639 no 97 0.0163546768633212 37 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_2275 7947463 200 µM 2.12273260859524 0.0154906432499579 no 98 0.0168881324328126 52 1225414
SGTC_2890 9046729 58.44 µM 2.12176482040023 0.01552932514863 no 99 0.016928746116927 60 903329
SGTC_1159 4092-0538 61.2 µM 2.11694344466612 0.0157232701873529 no 100 0.0171323239629545 48 717301
SGTC_857 0438-0306 1.35 µM 2.11002331574022 0.0160052691516242 no 101 0.0174281738136296 37 4686136
SGTC_1051 3253-3903 78 µM 2.10999524345862 0.0160064218837116 no 102 0.0174293827906404 50 5509239
SGTC_1012 4112-3522 18 µM 2.10655123706189 0.0161483840822074 no 103 0.0175782486852331 38 3112398
SGTC_1907 st060210 83.7 µM 2.10632792900353 0.016157625983718 no 104 0.0175879384472043 53 688793
SGTC_3270 9137563 49.47 µM 2.09667375100159 0.0165615331815792 no 105 0.0180112328386027 33 17015724
SGTC_2056 5235370 200 µM 2.0942508085754 0.0166642493216032 no 106 0.0181188219204128 45 5511916
SGTC_1721 st082152 9.2685 µM 2.08797500172988 0.0169328381713768 no 107 0.0184000448637314 51 5296051
SGTC_3210 9128157 49.47 µM 2.08747071174318 0.0169545802899345 no 108 0.0184228029292795 60 17590849
SGTC_2396 5342950 42.78 µM 2.07969366457882 0.017292916629531 no 109 0.0187768197835979 95 1886677
SGTC_1553 gossypol 38.6 µM 2.07486089250645 0.017506056139579 no 110 0.0189997145491971 27 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1246 0422-0085 105 µM 2.06645569006822 0.0178820937485601 no 111 0.0193927360798325 63 264295
SGTC_2320 7373003 200 µM 2.06174030759567 0.01809605464499 no 112 0.019616233422225 45 5415828
SGTC_1645 Cervolide 78 µM 2.06168791672259 0.0180984440902286 no 113 0.0196187288528894 43 23173 A fragrance.
SGTC_3252 9135871 49.47 µM 2.0599474225937 0.01817797764185 no 114 0.0197017837231505 44 17682838
SGTC_1259 0671-0132 43 µM 2.05196268879001 0.0185466761991321 no 115 0.0200866443138667 50 X1259
SGTC_1900 st060200 72.8 µM 2.03900430662302 0.0191585831634585 no 116 0.0207247988690217 53 688945
SGTC_1210 3013-0140 750 nM 2.03055986353227 0.0195665060765303 no 117 0.021149831358587 38 905973
SGTC_145 3737-0113 38.366 µM 2.0262044509496 0.0197797693122512 no 118 0.0213719188618273 121 6849351
SGTC_1812 st052057 4.327 µM 2.01810180544607 0.0201817675970992 no 119 0.0217903298492067 57 3645418
SGTC_3188 9110789 49.47 µM 2.01273528677733 0.0204518142894392 no 120 0.0220712425275142 57 849217
SGTC_1088 bifonazole 369 nM 2.00721288864757 0.0207328953952895 no 121 0.0223634999219573 35 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_2175 5807670 165.306 µM 2.00607018085833 0.0207914640507326 no 122 0.0224243803951225 25 241186
SGTC_501 nsc-95397 161 µM 1.98056084619045 0.0221358517700434 no 123 0.0238202717311771 48 262093
SGTC_1333 1482-0047 286 µM 1.97601662470511 0.022382879808386 no 124 0.0240764471692925 48 3811116
SGTC_264 promethazine 12.5 mM 1.97462138762109 0.0224591911672165 no 125 0.0241555650377749 87 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_2908 7930301 100 µM 1.97180344560742 0.0226139854150615 no 126 0.0243160244325914 52 2223178
SGTC_3065 9113888 49.47 µM 1.96968405910005 0.0227309985844387 no 127 0.0244372955259194 50 16648368
SGTC_2828 7998861 71.43 µM 1.96195163599242 0.02316224831791 no 128 0.0248840576349709 27 2988188
SGTC_2032 5185112 25.99 µM 1.95190875988614 0.0237326203158731 no 129 0.0254745190408358 33 5718189
SGTC_575 k072-0246 11.9 µM 1.94831669647758 0.0239394737545257 no 130 0.0256885402737638 50 6796779
SGTC_3103 9120822 49.47 µM 1.94629984197459 0.0240562795942149 no 131 0.0258093662856264 73 17141819
SGTC_784 4579-0127 173 µM 1.92327468011922 0.0254240492129659 no 132 0.0272227813459403 50 1948547
SGTC_3187 9109394 49.47 µM 1.92103357961076 0.0255605894065483 no 133 0.0273637371089816 67 17098090
SGTC_263 alizarin 107.927 µM 1.90592676663938 0.0264970861320546 no 134 0.0283298538707933 80 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_1029 k015-0030 64.7 µM 1.8997521554977 0.0268880297503668 no 135 0.0287328261644395 62 2208316
SGTC_369 0957-0393 4.5 µM 1.89707404711634 0.027059084460246 no 136 0.0289090829763018 63 6997992
SGTC_1418 3966-3099 2.4 µM 1.89030109447657 0.0274957391429594 no 137 0.0293588512525535 70 740335
SGTC_2476 5806916 10.51 µM 1.88734405854226 0.0276882143946569 no 138 0.0295570320458598 47 2870194
SGTC_1625 st003711 30.1 µM 1.88489532447347 0.0278484527122236 no 139 0.0297219857450902 55 24207034 YER133W GLC7
SGTC_2176 5809774 33.9695 µM 1.88203356433475 0.0280366965593704 no 140 0.0299157292853413 30 2870539
SGTC_414 piperonyl butoxide 100 µM 1.87779855496493 0.0283172148539247 no 141 0.0302043640169999 58 5794 A potent inhibitor of cytochrome P450.
SGTC_3152 9099253 49.47 µM 1.87431438842238 0.0285497466877414 no 142 0.0304435527546751 106 25236131
SGTC_3244 9134489 49.47 µM 1.8727813652646 0.0286525620512363 no 143 0.0305492911287583 64 16584271
SGTC_1798 st045719 60.953 µM 1.86735257757453 0.0290191339307544 no 144 0.0309261837870793 59 3980186
SGTC_307 1501-1223 22.3 µM 1.86426399031329 0.0292294204703962 no 145 0.0311423205232317 60 2830329
SGTC_1874 staurosporine 7.6 µM 1.86397968595177 0.0292488407959147 no 146 0.0311622785562771 62 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_1382 3002-2117 298 µM 1.84502155186726 0.0305682296406248 no 147 0.0325172017910209 54 1497314
SGTC_2088 5278280 127.392 µM 1.84233113332889 0.0307594030625791 no 148 0.032713364215664 58 791502
SGTC_2807 7945238 51.95 µM 1.84231991783558 0.0307602020704007 no 149 0.0327141839917423 57 17148797
SGTC_60 0986-0278 202 µM 1.83999833449222 0.0309259653035997 no 150 0.0328842409189687 50 3110598
SGTC_765 1319-0117 244 µM 1.83884422488881 0.0310086445275146 no 151 0.0329690506845652 52 3487746 YGL099W LSG1
SGTC_935 2996-0153 430 µM 1.83770521735887 0.0310904211031676 no 152 0.0330529273284798 55 23738523
SGTC_1668 st014914 51.6 µM 1.83097373583004 0.0315773677261749 no 153 0.0335522316688289 71 2839556
SGTC_3338 9144300 39.5675 µM 1.82875465109629 0.0317392683946524 no 154 0.0337181856574807 42 4901274
SGTC_19 0279-0214 38.434 µM 1.80724480398467 0.0333444110062653 no 155 0.0353620589718213 66 3566274 YBR002C RER2
SGTC_2765 myclobutanil 7.74 µM 1.80050877703276 0.0338606128761076 no 156 0.0358901694746803 81 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_2867 9039098 71.43 µM 1.78779256429124 0.034853010631616 no 157 0.0369047404875787 73 6463460
SGTC_2201 6605497 169.863 µM 1.7863494613844 0.0349671266754906 no 158 0.0370213465336207 54 670741
SGTC_2555 cholic acid 100 µM 1.78617157030612 0.0349812149508227 no 159 0.0370357413705783 47 6708657 Influences liver metabolism.
SGTC_2570 licareol 100 µM 1.78529108508714 0.0350510145353855 no 160 0.0371070570699595 76 443158
SGTC_1573 oleylamine 1.06 µM 1.76788843181428 0.0364542046813678 no 161 0.0385397785556142 67 5356789 An amine of the fatty acid oleic acid.
SGTC_2881 9058953 51.95 µM 1.76598824511513 0.0366101638126246 no 162 0.0386989104946086 68 17122249
SGTC_1913 st060213 96.1 µM 1.76488735557442 0.0367007695265657 no 163 0.0387913495961144 65 688959
SGTC_2801 7907800 81.82 µM 1.758254817017 0.0372505309402907 no 164 0.0393520809243838 68 6620925
SGTC_2138 5575593 77.673 µM 1.75638767368798 0.0374065036668904 no 165 0.0395111180549808 50 762213
SGTC_1296 1068-0102 11.9 µM 1.75450712447591 0.0375641350273795 no 166 0.0396718251038471 40 767053
SGTC_2846 9008642 19.48 µM 1.75243543613166 0.0377384154896133 no 167 0.0398494813090877 83 2992898
SGTC_2255 7941087 197.44 µM 1.74892530574093 0.0380352107595459 no 168 0.0401519658314417 69 935561
SGTC_1235 benzylparaben 21.5 µM 1.74780085468118 0.0381306892086435 no 169 0.0402492586416755 71 7180
SGTC_147 4466-0538 29.23 µM 1.74264223355172 0.0385712222932294 no 170 0.0406980639652584 77 6742687 YHR072W ERG7
SGTC_2967 9089538 49.85 µM 1.74090996571169 0.0387200804682732 no 171 0.0408496807902242 86 728216
SGTC_1054 3429-0080 167 µM 1.73580524202619 0.039161465840979 no 172 0.041299138463513 60 1162877
SGTC_2670 beta-carotene 100 µM 1.73528487592276 0.0392066889560285 no 173 0.0413451796232145 35 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_2366 9070441 60.58 µM 1.73418998516438 0.039301980711008 no 174 0.0414421896618203 65 6837235
SGTC_1076 itraconazole 331 nM 1.73353516553391 0.0393590617112553 no 175 0.0415002963987943 81 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_865 0488-0499 301 µM 1.73199542250377 0.0394935477950487 no 176 0.041637188728252 62 9634651
SGTC_1314 1222-0010 41.1 µM 1.72961706689112 0.0397020153781521 no 177 0.0418493573655964 64 3526027
SGTC_107 0358-0022 2.6945 µM 1.72467249447905 0.0401382807897983 no 178 0.0422932553236239 59 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_1759 st043059 70 µM 1.72122485109126 0.0404447687815893 no 179 0.0426050149859263 84 669426
SGTC_2506 ethyl hematommate 54.16 µM 1.72095433907163 0.040468896888183 no 180 0.0426295549581596 50 3940691 An allergen.
SGTC_933 2914-0560 114 µM 1.72009529024019 0.0405455965648612 no 181 0.0427075608589786 69 463887
SGTC_1304 1165-0502 251 µM 1.71312578154152 0.0411722365366517 no 182 0.0433447009497793 77 767425
SGTC_3038 9091290 49.47 µM 1.71169882322193 0.0413015001985941 no 183 0.0434760928014778 60 25236843
SGTC_2515 chrysin 20.77 µM 1.70518742225226 0.0418955288621815 no 184 0.0440797375253968 59 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_855 0428-0020 25 µM 1.70442169652701 0.0419658375731587 no 185 0.0441511666908096 80 6812414
SGTC_610 4215-0184 155 µM 1.7034971643722 0.0420508551006957 no 186 0.0442375341085542 83 5605015
SGTC_2629 bisabolol 100 µM 1.70178748371246 0.042208440046375 no 187 0.0443976068169744 96 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_1716 st033144 30.6155 µM 1.70064240494591 0.0423142513735095 no 188 0.0445050781489003 76 674617
SGTC_407 eburnamonine 100 µM 1.69169048199884 0.0431488718933679 no 189 0.0453525020768518 68 3195
SGTC_2770 toltrazuril 17.5 µM 1.69011092494469 0.0432975107596296 no 190 0.0455033675912459 60 68591 Kills coccidiodes.
SGTC_2289 7946404 165.07 µM 1.68362945119798 0.0439117623097057 no 191 0.0461266516544251 101 1246120 YPR165W RHO1
SGTC_638 3970-0837 4.09 µM 1.67193938750686 0.0450373907214366 no 192 0.0472681374532286 64 4118451 YLR208W SEC13
SGTC_424 splitomicin 100 mM 1.66824398629145 0.0453980107758324 no 193 0.0476336511579652 66 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2661 dactinomycin 12.96 µM 1.6644972110552 0.0457660116167094 no 194 0.0480065539714517 63 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_18 0111-0177 500 nM 1.66362028097267 0.0458524872738409 no 195 0.0480941681669708 84 721752
SGTC_2595 hexamethylquercetagetin 100 µM 1.66277559010116 0.0459359078702836 no 196 0.0481786822818842 89 386331
SGTC_1483 3453-0561 55.9 µM 1.66276550725088 0.0459369043757499 no 197 0.0481796918216074 92 4546991
SGTC_652 0437-0092 114 µM 1.66129916568469 0.0460820104773729 no 198 0.0483266887554281 72 3091274
SGTC_1989 st071868 50.2 µM 1.66129363709662 0.0460825582707993 no 199 0.0483272436601019 81 16414057
SGTC_766 1391-0721 126 µM 1.65811549216612 0.0463983276785235 no 200 0.0486470787550504 84 1020919 YIL115C NUP159
SGTC_2128 5255449 168.493 µM 1.65714285320889 0.046495312082887 no 201 0.0487452984986866 80 736008
SGTC_2606 farnesol 9.78 µM 1.65505026085237 0.0467045216153901 no 202 0.0489571515372508 101 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1737 st035557 69.7 µM 1.65116174502326 0.0470952860855127 no 203 0.0493527760886032 86 5716916
SGTC_393 acivicin 6.25 µM 1.64954270135101 0.0472587578831776 no 204 0.0495182512916252 89 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_1807 st050092 58.9 µM 1.64949607619028 0.0472634722665233 no 205 0.0495230231922782 81 5008496
SGTC_2389 9091542 195.52 µM 1.64668773938025 0.0475481258049587 no 206 0.0498111227961308 93 3626624 YOL127W RPL25
SGTC_457 grayanotoxin iii 135 µM 1.64171871541228 0.0480551503067679 no 207 0.0503241556100366 101 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_2057 5236571 38.335 µM 1.64083781180466 0.0481454850025943 no 208 0.0504155434620743 79 54684039 YBR257W POP4
SGTC_3193 9111931 49.47 µM 1.63836091528626 0.0484002135074059 no 209 0.0506732136726109 80 17087244
SGTC_2063 5246145 200 µM 1.6363554488907 0.0486072479958062 no 210 0.0508826087456438 94 711240
SGTC_1227 3909-8010 46.6 µM 1.63344070253871 0.048909413725371 no 211 0.051188171227279 57 15982272
SGTC_1846 st056244 14.8 µM 1.62940091059877 0.0493306902093326 no 212 0.0516140880784579 67 5393182
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 1.62864704143277 0.0494096248184602 no 213 0.0516938798816111 90 165521
SGTC_2122 5258151 111.688 µM 1.62632317007059 0.0496535826516365 no 214 0.0519404626514981 87 2173356
SGTC_2850 9015429 58.44 µM 1.62547440004379 0.0497429249972976 no 215 0.0520307571343653 86 6457570
SGTC_1256 0570-0116 285 µM 1.62323789878916 0.0499789555418716 no 216 0.0522692795619895 94 410638
SGTC_2441 5730946 39.09 µM 1.62060719701862 0.0502577304681511 no 217 0.0525509538746289 77 1774275
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 1.61670334639046 0.0506737033839495 no 218 0.0529711656187011 81 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1611 st001856 99.4 µM 1.61263065141545 0.0511105852089891 no 219 0.0534123875675368 94 647478
SGTC_1776 st049249 45.9 µM 1.61149196648789 0.0512332677015964 no 220 0.0535362683937378 100 1822314
SGTC_108 0509-0257 621.132 µM 1.60653416596109 0.0517701567436578 no 221 0.0540782971466316 99 536624
SGTC_2665 lovastatin 100 µM 1.60559449807542 0.0518724173806973 no 222 0.0541815175670071 77 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_520 3584-0023 682 µM 1.60428988040585 0.0520146602437876 no 223 0.0543250853338402 96 1340790
SGTC_3141 9094609 49.47 µM 1.60066139772296 0.0524119047119013 no 224 0.0547259677213125 104 25236309 YDL196W YDL196W
SGTC_1106 tegaserod maleate 11.7 µM 1.59942437988874 0.0525478820182413 no 225 0.0548631693701332 98 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_1388 3346-4487 254 µM 1.5927403608135 0.0532874630660872 no 226 0.0556092245943233 87 3345614
SGTC_1126 isoteolin 1.0172 µM 1.5911698212371 0.0534624334789385 no 227 0.0557856813148978 83 133323
SGTC_1742 st038235 28.8875 µM 1.59066538426573 0.0535187281987568 no 228 0.0558424505743727 93 564103 YBR002C RER2
SGTC_90 0870-0863 4.608 µM 1.59056653638185 0.0535297650365103 no 229 0.0558535802391137 95 1738164
SGTC_2052 5265182 7.135 µM 1.58309682358901 0.0543690238646917 no 230 0.0566996987511985 86 1239884
SGTC_694 1315-0438 43.2 µM 1.5795741127693 0.0547684131637729 no 231 0.0571022157796537 67 6793154
SGTC_3289 9119912 71.43 µM 1.57715485253856 0.0550440388933661 no 232 0.0573799491886229 84 17014829
SGTC_35 0133-0054 64.071 µM 1.5742002198905 0.0553821447751081 no 233 0.0577205842707235 102 99677
SGTC_3320 9137005 35.139 µM 1.57005550069285 0.0558591964409839 no 234 0.0582010999389304 101 4908713
SGTC_2437 5741531 144.16 µM 1.56964232133024 0.0559069299987295 no 235 0.0582491734089565 104 2262990
SGTC_2949 9072542 2.23 µM 1.56811236320679 0.0560839623925307 no 236 0.0584274558776915 98 16457352
SGTC_151 3013-0144 2.285 µM 1.56364276667606 0.0566036751745421 no 237 0.0589507427481431 116 906558 YHR107C CDC12
SGTC_3243 9134147 49.47 µM 1.56342838831587 0.0566286975644127 no 238 0.0589759336328388 77 24282180
SGTC_2151 5563267 85.4165 µM 1.55912978283322 0.0571322753583742 no 239 0.0594828329127066 104 5310824
SGTC_3023 9089636 49.47 µM 1.55534415162073 0.0575786717366298 no 240 0.0599320636963514 79 17249241
SGTC_1258 0671-0043 57.1 µM 1.55486065899729 0.057635881532117 no 241 0.0599896293324013 94 4298767
SGTC_2642 cholecalciferol 100 µM 1.55413974272016 0.0577212677519806 no 242 0.0600755435278021 66 9821465 A vitamin D precursor, similar to steriods.
SGTC_2504 purpurogallin 52.29 µM 1.55320227760775 0.0578324510187012 no 243 0.0601874086923841 82 5281571 An antioxidant.
SGTC_455 paf C-16 10 µM 1.54883219129098 0.0583529660832426 no 244 0.0607110324436921 91 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_2816 7982706 58.44 µM 1.54699582024216 0.0585727887261104 no 245 0.0609321267697944 105 2981853
SGTC_3069 9117009 49.47 µM 1.54410053953194 0.0589206880193223 no 246 0.0612819890922838 69 41904981
SGTC_767 0929-0023 86 µM 1.54197752426306 0.0591768200144292 no 247 0.0615395277028892 111 1204563
SGTC_3004 9076122 71.4286 µM 1.54118785243654 0.0592723127794073 no 248 0.0616355365514511 88 44782551
SGTC_2196 6573537 42.6665 µM 1.53684764792878 0.0597993201064284 no 249 0.0621653110655256 93 2903087
SGTC_1897 st060201 15 µM 1.53645971972345 0.0598466022567447 no 250 0.0622128348108642 95 611878
SGTC_389 tpck 16.7 µM 1.53305402001136 0.060262959825213 no 251 0.0626312727101093 75 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_3227 9130768 49.47 µM 1.53288116920214 0.0602841516891719 no 252 0.062652568203947 75 17720899
SGTC_1677 st019204 53.9 µM 1.53254706183737 0.0603251304712843 no 253 0.0626937467579061 82 3945625
SGTC_1461 k072-0203 53.8 µM 1.53174670925262 0.0604233836118386 no 254 0.0627924755705076 81 5418714
SGTC_2407 paclitaxel 400 µM 1.52972880055555 0.0606716626571375 no 255 0.063041935827817 89 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1876 myriocin 605 nM 1.52949960042689 0.060699913327854 no 256 0.0630703190219674 100 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_235 0330-0087 5 mM 1.52669328884345 0.0610466474774606 no 257 0.0634186485074418 88 46494818 YHR062C RPP1
SGTC_2923 7992654 58.14 µM 1.52201403693274 0.0616282335178572 no 258 0.0640027817767059 92 2985126
SGTC_1309 pyrazolanthrone 13.4 µM 1.52101043423684 0.0617535333596345 no 259 0.0641286094478134 98 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_2143 5623677 140.463 µM 1.51863751247248 0.0620505837464295 no 260 0.0644268816816718 88 5375313
SGTC_2582 agaric acid 100 µM 1.51200669261111 0.0628865641948186 no 261 0.065266079988146 130 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_3105 9121040 49.47 µM 1.50967764280212 0.0631822726010987 no 262 0.0655628493818166 69 41448907
SGTC_454 lyso-paf C-16 6.67 µM 1.50855719610036 0.0633249156038057 no 263 0.0657059898676479 80 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_284 0988-0104 32.6 µM 1.48993611519631 0.0657324260018873 no 264 0.0681205172013022 99 4666532
SGTC_199 4063-0024 41.6 µM 1.48193133020685 0.066788916757988 no 265 0.0691792838210622 53 306215
SGTC_2614 arthonioic acid 13.39 µM 1.47989973491551 0.0670591309140655 no 266 0.0694500032280466 80 6710684
SGTC_502 l-744,832 89.3 µM 1.47830804841097 0.067271424683238 no 267 0.0696626722051545 82 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_2806 7952793 58.44 µM 1.47331048031679 0.0679413609994124 no 268 0.0703336680149491 95 2972490
SGTC_2220 6782180 200 µM 1.46147239896462 0.0695488328369248 no 269 0.0719429223897394 64 833803
SGTC_2362 9071156 126 µM 1.46043823078111 0.0696906399792019 no 270 0.0720848360713043 100 653133
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 1.45932391254902 0.0698436864675326 no 271 0.0722379884246531 74 2724278 An inhibitor of dopamine biosynthesis.
SGTC_1275 0867-0008 21.1 µM 1.45605050204794 0.0702947704897678 no 272 0.0726893296537303 90 3422836
SGTC_2380 9035439 200 µM 1.45595760008131 0.0703076052260761 no 273 0.0727021705151375 91 6462575
SGTC_304 1310-0298 97 µM 1.44760424322107 0.0714690329824161 no 274 0.0738638818914273 120 1550234
SGTC_154 3389-1638 511.116 µM 1.44211403946375 0.072240357687501 no 275 0.0746351025354849 107 5238686
SGTC_1169 aniline yellow 25.8 µM 1.43791697883467 0.0728342977588923 no 276 0.075228805794486 101 6051 A DNA damaging agent.
SGTC_828 2074-0507 139 µM 1.43664022608668 0.0730157149289512 no 277 0.075410123698515 105 X828
SGTC_122 0236-0016 402.397 µM 1.4349169118162 0.0732611333929607 no 278 0.0756553879399403 134 6808838
SGTC_1422 4031-0024 15.5 µM 1.43357523922556 0.0734526384998358 no 279 0.0758467568363388 109 782427
SGTC_2263 7948595 193.29 µM 1.43175705827369 0.0737127691868192 no 280 0.0761066803132577 90 2971371
SGTC_2368 9071271 200 µM 1.43120383825544 0.0737920590242889 no 281 0.0761859019243333 89 27209959
SGTC_2522 biochanin a 4.94 µM 1.43100473096677 0.0738206118717812 no 282 0.076214429624482 97 5280373 A possible chelator.
SGTC_2248 tofa 1.1 µM 1.42978290633344 0.073996011739036 no 283 0.0763896683018136 126 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1707 st032323 6.317 µM 1.42838451571219 0.074197149220247 no 284 0.0765906067680917 126 3132057 YMR211W DML1
SGTC_2200 6600604 21.907 µM 1.42269595643463 0.0750196694260451 no 285 0.0774121566602832 117 2904777
SGTC_1958 st076513 41.9 µM 1.42176833496671 0.0751544530140407 no 286 0.0775467574270672 111 732122 YGL099W LSG1
SGTC_829 1635-0120 117 µM 1.41171395620423 0.0766272254643171 no 287 0.0790171011661746 141 285054
SGTC_2869 9037858 32.47 µM 1.41086808306792 0.076752123624862 no 288 0.0791417573871898 95 27187042
SGTC_1345 1488-0192 31.4 µM 1.40889044580678 0.0770447373960903 no 289 0.0794337825481704 99 658348
SGTC_1524 corynanthine 62.1 µM 1.40638975206244 0.07741595616957 no 290 0.079804210835136 111 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_1270 0831-1170 17.3 µM 1.40605819083238 0.0774652770379388 no 291 0.0798534230095817 116 6764716
SGTC_2447 5741742 33.78 µM 1.40387879716317 0.0777900634230126 no 292 0.0801774722266181 120 1776504
SGTC_2099 5377090 177.372 µM 1.40090918357866 0.0782342754143209 no 293 0.080620616099586 125 2243829
SGTC_601 0986-0029 62.9 µM 1.39979127239567 0.0784019965602409 no 294 0.0807879160554398 116 24747981
SGTC_1050 3232-1156 69.3 µM 1.39271163030801 0.079470497136031 no 295 0.0818535051065437 123 700529
SGTC_3165 9101544 49.47 µM 1.39176875171075 0.0796136294710967 no 296 0.0819962176840637 106 5002184
SGTC_931 2812-0076 566 µM 1.38832841474153 0.080137539362175 no 297 0.0825185317659678 114 3450959
SGTC_1550 gossypolone 36.6 µM 1.37580446082495 0.0820667666428336 no 298 0.0844410900125534 116 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1750 st081859 2.357 µM 1.3700871768002 0.0829590202442888 no 299 0.0853298451060462 150 5291695
SGTC_2445 5742597 35.57 µM 1.36793278807541 0.0832971258429999 no 300 0.085666557716233 135 1774255
SGTC_339 3091-4833 71.4 µM 1.3639247814813 0.0839288893252211 no 301 0.0862956202136564 142 3240077
SGTC_697 0508-1955 564 µM 1.36185364155168 0.0842567603551632 no 302 0.08662203944599 106 6243113
SGTC_55 0767-0285 6.563 µM 1.36145973213607 0.084319226691774 no 303 0.0866842253269118 108 3116166
SGTC_2862 9027634 71.43 µM 1.36120412959677 0.0843597788485389 no 304 0.0867245947568259 116 5012562
SGTC_1727 st034309 9.9045 µM 1.36000820596116 0.0845497103852862 no 305 0.0869136635678452 146 870305
SGTC_2841 9004761 38.96 µM 1.35867915394279 0.0847611609344947 no 306 0.0871241402993861 91 2991039
SGTC_1828 st055811 49 µM 1.35817342144487 0.0848417264270504 no 307 0.0872043310641381 93 5877589
SGTC_2832 7992762 51.95 µM 1.35528432096115 0.085303074484694 no 308 0.0876634942288443 106 2985177
SGTC_2617 dihydrotanshinone i 20.83 µM 1.35451605159756 0.0854260718818983 no 309 0.087785897933382 136 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_124 0136-0217 7.121 µM 1.35272176579551 0.0857138484524099 no 310 0.0880722671207609 148 3976905
SGTC_378 3970-0959 8.33 µM 1.35253121360954 0.0857444527479074 no 311 0.0881027202378666 127 6615653
SGTC_2795 7780010 54.55 µM 1.34827749765342 0.0864297667016536 no 312 0.0887845734126209 127 953673
SGTC_551 k048-0028 34.9 µM 1.34823617387641 0.0864364443814258 no 313 0.088791216662399 134 6836383
SGTC_296 1222-0039 74.9 µM 1.347724143432 0.0865192174999323 no 314 0.0888735618738898 99 5984176
SGTC_3161 9100388 49.47 µM 1.3447683172213 0.0869982051429376 no 315 0.0893500323658218 117 25236368
SGTC_2268 7933382 153.85 µM 1.34201618697282 0.0874459622769892 no 316 0.0897953736308015 116 935025 YOR257W CDC31
SGTC_2207 7258803 200 µM 1.33903556601766 0.0879328313628212 no 317 0.09027954740557 116 3666799
SGTC_2212 7123476 200 µM 1.33838822787278 0.0880388374007531 no 318 0.0903849571941042 86 1085715
SGTC_916 4466-0038 42 nM 1.33814179331069 0.0880792177732419 no 319 0.0904251095589754 160 5722064 YGL116W CDC20
SGTC_2066 5222451 176 µM 1.33593032313146 0.0884422038748637 no 320 0.090786024290481 156 2281147
SGTC_89 0302-0250 142.109 µM 1.33434722475848 0.0887027340597563 no 321 0.0910450436942725 125 4203518 YLR208W SEC13
SGTC_900 1112-0045 141 µM 1.33298771684412 0.088926923821879 no 322 0.0912679173737017 113 56211 YIL048W NEO1
SGTC_2829 7992743 58.44 µM 1.3323975288992 0.0890243800172774 no 323 0.0913647968507618 106 16462845
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 1.3288056568949 0.089619211218029 no 324 0.091956047700337 135 688798
SGTC_1280 0880-0253 10.1 µM 1.3251131746335 0.0902337793521996 no 325 0.0925668085435532 124 6836607
SGTC_39 0986-0283 58.349 µM 1.32345010993149 0.090511596187529 no 326 0.0928428684804614 104 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_1671 st016596 74.5 µM 1.3230066690123 0.0905857806187703 no 327 0.0929165800203061 124 2829167
SGTC_1415 3966-0071 78.1 µM 1.32080115883828 0.0909554169684304 no 328 0.0932838366150583 111 2893185
SGTC_249 wiskostatin 11.211 µM 1.32017528863809 0.0910605143183309 no 329 0.0933882502120218 118 2775510 A n-wasp and actin depolymerizer.
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 1.31685525499028 0.091619527407401 no 330 0.0939435736647535 133 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_1817 st052116 64.4 µM 1.31174455308806 0.0924850094020713 no 331 0.0948031693728508 97 4361398
SGTC_2933 9026794 32.47 µM 1.3068796776874 0.0933144669298248 no 332 0.095626789527574 119 17586027
SGTC_175 3793-3120 23.7 µM 1.30611614084403 0.0934451468025305 no 333 0.0957565323847536 110 5322297
SGTC_2956 9076196 2.52 µM 1.30566408638434 0.0935225799237999 no 334 0.0958334080697796 129 16423868
SGTC_2252 omeprazole 400 µM 1.30275684161506 0.0940216991151177 no 335 0.0963288946863331 88 4594 A proton pump inhibitor.
SGTC_2932 9016711 44.54 µM 1.30271343829084 0.0940291655111026 no 336 0.0963363062250931 122 7117328
SGTC_1969 st069479 40.1 µM 1.29999659514592 0.0944973978654442 no 337 0.0968010680719519 115 3895485
SGTC_1665 st014639 11.4 µM 1.29352016013243 0.095620503493204 no 338 0.097915608022899 130 981133 YIL048W NEO1
SGTC_1971 st069429 63.5 µM 1.2932004460669 0.0956761997652329 no 339 0.0979708707176898 95 1246522 YGL099W LSG1
SGTC_1950 st077106 7.18 µM 1.29254483292313 0.0957904864968237 no 340 0.0980842651784256 106 13831864
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 1.2923339048906 0.0958272768949575 no 341 0.0981207676036948 138 689007
SGTC_2246 7293507 91.5585 µM 1.2912618014776 0.0960144355374391 no 342 0.0983064557170555 138 887656
SGTC_332 4112-0506 40.9 µM 1.29112077482226 0.0960390747549331 no 343 0.0983309006490373 155 2790355
SGTC_2123 5259487 200 µM 1.28687151309586 0.0967836588488316 no 344 0.0990695379255553 121 2173474
SGTC_1079 idarubicin 2.36 µM 1.28656660295053 0.0968372498020567 no 345 0.0991226952355194 139 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1862 st057513 3.81 µM 1.28405227384863 0.0972799987099078 no 346 0.0995618328122391 127 5393163
SGTC_1435 4092-0789 56.7 µM 1.28198375538016 0.0976453568323042 no 347 0.0999241724085295 149 2248285
SGTC_1965 Pectolinarigenin 58.4 µM 1.28057180848089 0.0978953232262693 no 348 0.10017205369636 121 5320438 An anti-inflammatory.
SGTC_1854 st056233 32.9 µM 1.27898460611636 0.0981768758332648 no 349 0.100451238413148 134 5393174
SGTC_3282 9108498 15.4605 µM 1.276580593895 0.0986044506757406 no 350 0.100875178360721 136 16459645
SGTC_1072 oxiconazole 14.9 nM 1.27366733746685 0.0991244239834439 no 351 0.101390668361527 140 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1788 fluconazole 20 µM 1.27248808148315 0.0993354729764853 no 352 0.101599878056018 128 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_3220 9131269 49.47 µM 1.2714393101535 0.0995234452376924 no 353 0.101786202647658 118 17722206
SGTC_3086 9117350 49.47 µM 1.27067155461917 0.0996612154936883 no 354 0.101922759618125 90 2679265
SGTC_1983 st071813 46.9 µM 1.26602077093177 0.100498757234572 no 355 0.102752822982397 136 11838595
SGTC_2079 5212404 121 µM 1.26398581871249 0.100866834650082 no 356 0.103117558514195 111 758462
SGTC_2748 diazoxide 86.69 µM 1.26342704576438 0.100968075991507 no 357 0.103217874766286 72 3019 A potassium channel activatior.
SGTC_932 2857-0803 154 µM 1.26126493101221 0.101360516886572 no 358 0.103606705827308 134 674898
SGTC_2998 9066762 71.4286 µM 1.26063182232304 0.101475641165992 no 359 0.103720763952047 117 4945196
SGTC_2262 9014885 67.46 µM 1.25729936058808 0.102083185120394 no 360 0.104322627723754 111 6457424
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 1.25069535934241 0.103294976723154 no 361 0.105522822110267 129 688751
SGTC_2683 piperine 63.03 µM 1.25062745353903 0.103307491013665 no 362 0.105535214790451 148 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2402 5553605 200 µM 1.2500811312902 0.103408212230737 no 363 0.1056349558623 121 6758546
SGTC_1271 0832-2808 169 µM 1.24811282207182 0.103771685234362 no 364 0.105994871662977 151 3663794
SGTC_458 nppb 133 µM 1.24797114089888 0.103797884153308 no 365 0.106020812964337 113 4549 A chloride channel blocker.
SGTC_746 1095-0025 46.6 µM 1.24777099475833 0.10383490227488 no 366 0.106057466803293 140 6749286
SGTC_2119 5528445 120.635 µM 1.24231659283554 0.104847412841948 no 367 0.107059887828681 126 791935
SGTC_1685 st024049 53.0905 µM 1.24217559008118 0.104873681897887 no 368 0.107085891902628 136 1941139
SGTC_561 1550-0330 72.9 µM 1.24091583078512 0.105108588717614 no 369 0.107318421978179 139 6812934
SGTC_1171 0368-0077 21.4 µM 1.23738497045262 0.105769015705082 no 370 0.107972097920601 138 3239779
SGTC_2324 6149169 200 µM 1.23702959353124 0.105835652685035 no 371 0.108038048094557 139 2888231
SGTC_350 k064-0020 19.8 µM 1.2339586261419 0.106412756396284 no 372 0.108609160888341 137 2790705
SGTC_2790 5423970 71.43 µM 1.23127366576882 0.106919179572538 no 373 0.109110263848547 152 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_102 gallobenzophenone 83.616 µM 1.23117784978202 0.106937283958508 no 374 0.109128176953792 136 70837
SGTC_1033 k072-0102 21.3 µM 1.23041952323157 0.107080647423715 no 375 0.109270023083146 139 5965931
SGTC_2061 5245884 80.95 µM 1.22968206989553 0.107220197653176 no 376 0.109408091841555 144 573863
SGTC_2557 derrustone 83.84 µM 1.22926177853982 0.107299789129392 no 377 0.109486836389209 142 629853 An antioxidant.
SGTC_2926 9010726 65.15 µM 1.22678515810253 0.107769657150693 no 378 0.10995167531999 128 2994293
SGTC_3349 9149703 23.001 µM 1.22447268935472 0.108209718459117 no 379 0.110386981394914 121 4910494
SGTC_581 0958-0271 211 µM 1.22419341694958 0.108262951224223 no 380 0.110439635985421 110 4591145
SGTC_977 1348-1378 135 µM 1.22389864226539 0.108319159358037 no 381 0.110495232939078 149 X977
SGTC_1626 st003712 1.76 µM 1.22269054787334 0.108549740237428 no 382 0.110723299193971 161 24207035
SGTC_807 1315-0151 48 µM 1.22006404012878 0.109052261980501 no 383 0.111220299553757 176 4011080
SGTC_3088 9117578 49.47 µM 1.21712719537339 0.109616137089732 no 384 0.111777912497705 145 678341
SGTC_1652 st011932 78 µM 1.21697907359029 0.109644631869781 no 385 0.111806088963841 145 1551076
SGTC_2313 7726885 200 µM 1.21459985584982 0.110103060449663 no 386 0.112259371939357 142 726423
SGTC_3286 9117135 37.221 µM 1.21308302899361 0.110396040034764 no 387 0.11254903889253 132 3438150
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 1.2113848517414 0.110724710731632 no 388 0.112873971146203 147 390807
SGTC_1795 st049545 62.3 µM 1.2111458585652 0.110771022468048 no 389 0.112919754226071 107 5291882
SGTC_752 1896-0090 130 µM 1.20877542258709 0.111231113633811 no 390 0.113374568148576 148 772567
SGTC_1979 st071809 45.3 µM 1.2059814991334 0.11177515655306 no 391 0.113912312027095 146 4976333
SGTC_849 0386-0493 241 µM 1.20507811200352 0.111951473903995 no 392 0.114086574321444 153 726119
SGTC_3119 9125183 49.47 µM 1.20498432659097 0.111969789732304 no 393 0.114104676289678 101 22695334
SGTC_2667 digitoxin 100 µM 1.20468822034022 0.112027631883188 no 394 0.114161842591208 100 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_2716 st080858 38.6235 µM 1.20459036211125 0.112046752455273 no 395 0.114180739594323 129 5296050
SGTC_135 0933-0004 26.348 µM 1.20242940725483 0.112469577337662 no 396 0.114598600660177 147 21230617 YGL099W LSG1
SGTC_196 k015-0023 18.111 µM 1.20194365903537 0.112564778339172 no 397 0.114692678795483 113 5211998
SGTC_584 0986-0246 15.4 µM 1.20055764168099 0.112836738008593 no 398 0.114961420212063 186 53315 YDR232W HEM1
SGTC_763 3453-1109 128 µM 1.19961366490508 0.113022230295996 no 399 0.115144708500435 137 1560353
SGTC_2666 tannic acid 100 µM 1.19898246424599 0.113146383141295 no 400 0.11526738212427 163 16134267 A thiamine antagonist.
SGTC_1421 4029-0249 71.4 µM 1.19877388594123 0.113187430447811 no 401 0.115307939658381 154 2894095
SGTC_1196 1588-0294 184 µM 1.19723247676203 0.113491102493047 no 402 0.115607977326463 150 6144269
SGTC_3261 9137475 49.47 µM 1.1965403778818 0.113627641281038 no 403 0.115742875706077 76 17027690
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 1.19565913144513 0.113801664950011 no 404 0.115914802965976 151 688664
SGTC_734 2023-0417 80 µM 1.19500131037752 0.113931691571746 no 405 0.116043259073031 158 3935732
SGTC_1988 st071872 53.4 µM 1.19381265301155 0.114166913062868 no 406 0.116275630520545 112 16414116
SGTC_1937 st074714 47.2 µM 1.19310766437223 0.11430658542807 no 407 0.116413605117564 127 17250970
SGTC_1343 1487-0095 224 µM 1.19168989699365 0.114587841824922 no 408 0.116691430479191 161 4560101 YGL055W OLE1
SGTC_919 tnp00227 403.569 nM 1.19147555960916 0.114630404852063 no 409 0.116733472856999 139 1269246 A methoxyflavone. YNL221C POP1
SGTC_600 1495-0418 41.6 µM 1.18719588797383 0.115482616286001 no 410 0.11757518124028 162 5377768
SGTC_1519 esterone 74 µM 1.18648224835442 0.11562516022238 no 411 0.117715953877765 141 698 A steroid.
SGTC_2602 kawain 100 µM 1.18440664101371 0.116040456858869 no 412 0.118126066314477 149 5369129
SGTC_231 b-estradiol 524 µM 1.18420197193109 0.116081465228445 no 413 0.118166560871318 132 450 A steroid.
SGTC_1398 3558-0053 112 µM 1.18101758821095 0.116720827357364 no 414 0.118797868168357 118 4532369
SGTC_799 1310-0557 151 µM 1.17863631230375 0.117200569969513 no 415 0.119271512867909 155 5354492
SGTC_1413 3910-0535 34.4 µM 1.17850947785543 0.117226161734674 no 416 0.119296778046616 151 2876951
SGTC_739 1486-1183 203 µM 1.17575303105209 0.11778331628969 no 417 0.119846790176874 126 4346692
SGTC_3067 9117431 49.47 µM 1.17501461006084 0.117932889429854 no 418 0.119994435365816 184 17150885
SGTC_1335 1486-0900 202 µM 1.17195888417482 0.118553279888011 no 419 0.120606781982885 130 X1335
SGTC_817 1391-0715 46 µM 1.1713062299137 0.118686083742465 no 420 0.120737854085813 174 1353946
SGTC_56 0957-0365 83.25 µM 1.17015567779596 0.118920457096225 no 421 0.12096916279289 151 6752360
SGTC_2918 7977171 22.06 µM 1.16952430675623 0.119049209413445 no 422 0.121096226981063 153 2236483
SGTC_3093 9117344 49.47 µM 1.16746935458976 0.119468946832098 no 423 0.121510438583165 136 24824913
SGTC_700 3453-2283 142 µM 1.16393765862206 0.1201927558622 no 424 0.122224638414714 143 565664
SGTC_938 3126-1755 342 µM 1.16210487422004 0.120569594181717 no 425 0.122596433889351 134 1777771
SGTC_3198 9112019 49.47 µM 1.16105130623719 0.120786594204861 no 426 0.122810517665283 171 45595555
SGTC_1279 0874-0590 65.2 µM 1.15950887300353 0.121104779816278 no 427 0.123124410936729 134 3523074
SGTC_2433 5607874 27.82 µM 1.1591747226645 0.121173788686068 no 428 0.123192486327228 136 2252428
SGTC_2035 5154463 94.595 µM 1.15818515618084 0.121378316599086 no 429 0.123394242283892 181 2769623
SGTC_2592 piperlongumine 83.33 µM 1.15440733849096 0.122161364087953 no 430 0.124166603975368 161 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_2771 fluoxetine 41.05 µM 1.15353133457608 0.122343443330367 no 431 0.124346181933816 129 3386 A selective serotonin reuptake inhibitor.
SGTC_31 0508-1974 57.237 µM 1.1519439168585 0.122673876571042 no 432 0.124672060032956 132 6810525
SGTC_2411 st077133 39.94 µM 1.14916377146432 0.123254092547184 no 433 0.125244228231922 161 1403142 YNL221C POP1
SGTC_2102 5377816 72.7585 µM 1.14875594686575 0.123339366954135 no 434 0.125328314583564 164 1379702
SGTC_211 3455-0679 143.504 µM 1.14796258258065 0.12350537448783 no 435 0.125492005413741 123 748649
SGTC_488 nitrendipine 139 µM 1.14556814380874 0.124007347589449 no 436 0.12598694231988 134 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_1954 st077032 68.9 µM 1.14476522707979 0.124175991244152 no 437 0.126153211678415 153 698907
SGTC_2435 5706476 10.6 µM 1.14336304410009 0.124470888674356 no 438 0.126443944786315 143 5725375
SGTC_925 2064-1272 59.6 µM 1.13696976811614 0.125821683067505 no 439 0.127775462022912 157 6815817
SGTC_2291 7917025 104.35 µM 1.13674424331904 0.125869518740793 no 440 0.127822608988929 140 2964612
SGTC_2378 9074213 121.43 µM 1.13350739813943 0.126557477989044 no 441 0.128500618084215 160 657714
SGTC_2981 9013952 38.96 µM 1.13129124396918 0.127030007376323 no 442 0.128966264243225 145 2996344
SGTC_2497 7-hydroxyflavone 100 µM 1.13114981302148 0.12706020497201 no 443 0.128996020610074 170 5281894
SGTC_1884 5633444 25 µM 1.13063315534726 0.127170561471226 no 444 0.129104763274241 149 5724239
SGTC_436 n,n-dimethylsphingosine 3.3 µM 1.12237894373067 0.128942683194252 no 445 0.130850676678811 170 5282309
SGTC_1616 st002734 56.1 µM 1.12087140323081 0.129268182361766 no 446 0.131171302497764 163 4026101
SGTC_1013 4112-3890 241 µM 1.12006144383945 0.129443298969858 no 447 0.131343789706752 159 705171
SGTC_333 3486-0131 40.1 µM 1.11949267042989 0.129566368359162 no 448 0.131465008033191 157 6744690
SGTC_2575 plumbagin 510 nM 1.11693333038112 0.130121153115587 no 449 0.132011416109333 167 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_2600 tangeritin 87.95 µM 1.11573695378992 0.130381053133711 no 450 0.132267373801869 181 68077 A bioactive flavone.
SGTC_480 am 92016 50 µM 1.11406303680215 0.130745296026359 no 451 0.132626072285125 191 2129 K+ channel blocker.
SGTC_1038 k292-0204 154 µM 1.11395090848728 0.130769720163259 no 452 0.132650123838488 149 4454212
SGTC_2295 7971645 200 µM 1.11339205612425 0.130891498145337 no 453 0.132770042622514 142 2978226 YKL099C UTP11
SGTC_1835 st008666 49.2 µM 1.11300505502473 0.13097587440366 no 454 0.132853129226921 120 690455
SGTC_639 0833-0042 114 µM 1.11211625291186 0.131169798521957 no 455 0.133044084740129 175 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_1044 1222-0021 1.78 µM 1.1120257502562 0.131189556047815 no 456 0.133063539459956 185 4306703
SGTC_1849 st056239 19.2 µM 1.10990379191151 0.131653387366876 no 457 0.133520243167474 156 5393181
SGTC_477 mead ethanolamide 10 µM 1.1090879790934 0.131832013815735 no 458 0.133696115060999 98 16061185
SGTC_2174 5790901 200 µM 1.10715441584275 0.132256045044437 no 459 0.134113586040503 159 786020
SGTC_659 k018-0002 107 µM 1.10628462712077 0.132447096330561 no 460 0.134301671749551 154 6797879 YHR007C ERG11
SGTC_1116 jasmonic acid 1.58368 µM 1.1062299702124 0.132459108205961 no 461 0.134313496968846 162 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_971 1315-0384 26.7 µM 1.106096185571 0.132488513044459 no 462 0.134342444775644 159 6769120
SGTC_1336 1486-0901 104 µM 1.10450431015362 0.132838740234232 no 463 0.134687217448008 153 5006114
SGTC_390 dec-rvkr-cmk 16.7 µM 1.10431713901587 0.132879961448074 no 464 0.13472779533717 146 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_1722 st034304 3.6505 µM 1.1038107210324 0.132991535421035 no 465 0.134837626606276 158 4036148 YLR033W RSC58
SGTC_1024 4507-0395 26 µM 1.10327759928081 0.133109062431894 no 466 0.13495331570826 155 4201836
SGTC_416 estradiol valerate 100 µM 1.10301546905033 0.133166875405716 no 467 0.135010223756284 173 13791 A steroid.
SGTC_2452 5863136 48.41 µM 1.10149832080771 0.133501822747118 no 468 0.135339917459604 155 2184096
SGTC_219 mitoxanthrone 164.414 µM 1.10030730665814 0.133765173710411 no 469 0.135599124837033 170 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_3285 9112818 20.8695 µM 1.09822392941932 0.134226697671106 no 470 0.136053359790786 191 17017947 YPR165W RHO1
SGTC_1687 st020778 55.3625 µM 1.08870738691864 0.136348767402702 no 471 0.138141471632188 154 4259299
SGTC_485 niflumic acid 177 µM 1.08713418873386 0.136701769616757 no 472 0.138488755167919 147 4488 A COX2 inhibitor.
SGTC_2558 carylophyllene oxide 100 µM 1.08692816641712 0.136748044182858 no 473 0.13853427861771 168 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_2922 7999257 32.47 µM 1.08605088452082 0.136945209895574 no 474 0.138728240198313 162 2988377
SGTC_379 3970-0972 5.9 µM 1.08373031692555 0.137467684749341 no 475 0.139242194722199 154 2898042 YBL034C STU1
SGTC_912 3474-0017 2.18 µM 1.07971317937157 0.138375355180204 no 476 0.140134961596437 158 3360550
SGTC_869 0564-0080 44.1 µM 1.07964746438869 0.138390237329901 no 477 0.14014959831904 139 6843321
SGTC_1666 st014829 29 µM 1.07945472241702 0.138433892950155 no 478 0.140192533799971 152 3858230
SGTC_1449 4112-4002 201 µM 1.07867972813576 0.138609522130625 no 479 0.140365262832891 152 2059539
SGTC_2810 7959871 45.46 µM 1.07797626171005 0.138769073050094 no 480 0.140522174966258 176 2974535
SGTC_2523 spermine 47.74 µM 1.07721621377115 0.138941597566967 no 481 0.140691841705166 147 1103 A DNA binding polyamine.
SGTC_8 0354-0001 70 µM 1.07688337681295 0.13901719472894 no 482 0.140766185193799 179 4993152
SGTC_3008 9078912 71.4286 µM 1.07635310580442 0.139137692862586 no 483 0.140884683215106 177 16648731
SGTC_1530 rhein 70.4 µM 1.07624547365102 0.139162159737387 no 484 0.140908743698772 166 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_2616 abietic acid 100 µM 1.07194778949688 0.140141499773092 no 485 0.141871741747819 176 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_1344 1488-0097 29.1 µM 1.06925349428166 0.140757847710308 no 486 0.142477729986195 177 747966
SGTC_2340 7987427 183.45 µM 1.06777081595477 0.141097809197183 no 487 0.142811952766842 163 2239331
SGTC_1178 0988-0033 191 µM 1.06464255829555 0.141816908951071 no 488 0.143518856605112 162 5392207
SGTC_3260 9137109 49.47 µM 1.06411307140573 0.141938868473462 no 489 0.1436387400295 158 17478346
SGTC_499 genistein 192 µM 1.06286563146701 0.142226478580262 no 490 0.143921445426698 158 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_2778 tioconazole 65.09 nM 1.06266082950727 0.142273735439422 no 491 0.143967895223336 179 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1460 k062-0059 9.15 µM 1.06264673463086 0.14227698814075 no 492 0.14397109236216 164 1373085
SGTC_1787 fluconazole 80 µM 1.06223488989978 0.142372052544408 no 493 0.144064532186574 167 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_1587 estradiol valerate 56.1 µM 1.06186918531793 0.142456502620752 no 494 0.144147537950997 189 13791 A steroid.
SGTC_3326 9140064 16.379 µM 1.06062887489549 0.142743172732003 no 495 0.144429297400477 159 1868434
SGTC_1201 1889-3372 45.9 µM 1.05792139455072 0.143370300483759 no 496 0.145045640210093 164 5392199
SGTC_73 0327-0325 16.231 µM 1.0554619339056 0.143941590245074 no 497 0.145607055115779 132 53298
SGTC_2694 st077685 81.9 µM 1.05497161716014 0.144055665577642 no 498 0.145719152931837 155 2838096
SGTC_336 4111-0029 111 µM 1.0547054475659 0.144117617163237 no 499 0.145780029782406 154 3131175
SGTC_2677 mitomycin C 100 µM 1.05416509089755 0.144243441668646 no 500 0.145903669770149 182 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2310 7668677 200 µM 1.05253860928388 0.144622622120884 no 501 0.146276253153407 196 2197143
SGTC_3024 9090631 49.47 µM 1.04921520454281 0.145399491072369 no 502 0.147039541169773 145 25236383
SGTC_2952 9073731 13.78 µM 1.04705994339547 0.145904796107334 no 503 0.147535966200292 172 16457353
SGTC_542 3381-0244 89.3 µM 1.04690894870941 0.145940241276233 no 504 0.147570787104297 183 1112843
SGTC_540 1187-0821 17.3 µM 1.04631344233908 0.146080089514528 no 505 0.147708170572954 181 847520
SGTC_1420 4'-methoxyflavone 42 µM 1.04549648338289 0.14627208992312 no 506 0.147896782523013 167 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_1350 1495-0454 146 µM 1.0454651719638 0.146279452054036 no 507 0.147904014621523 165 1069057
SGTC_3113 9123498 49.47 µM 1.04446139455472 0.146515598146105 no 508 0.14813598574834 205 8897275
SGTC_969 1313-0238 134 µM 1.04442263237383 0.146524722365691 no 509 0.148144948497081 204 5212874
SGTC_2187 6125751 200 µM 1.04392741836196 0.146641324222943 no 510 0.148259485820918 179 874498
SGTC_1739 st037196 92.5 µM 1.04312998136179 0.1468292175849 no 511 0.148444048333988 148 612214
SGTC_306 1672-3436 11.6 µM 1.04303621106682 0.146851322496766 no 512 0.14846576105727 174 6797378
SGTC_3299 9121982 43.1275 µM 1.03972224543136 0.14763397279444 no 513 0.149234481204399 158 17594604 YPL160W CDC60
SGTC_2325 6158266 200 µM 1.03923554231821 0.147749151006252 no 514 0.149347602153854 158 3623240
SGTC_1686 st019653 115.5 µM 1.03792216247514 0.148060262341801 no 515 0.149653147311317 184 97252
SGTC_1944 st076371 56.9 µM 1.03753684491256 0.148151618875764 no 516 0.149742866802459 168 24208455
SGTC_1976 st070609 63.5 µM 1.03570614349484 0.148586182683867 no 517 0.150169627691203 171 682556
SGTC_1780 st038448 24.544 µM 1.0330880190618 0.149209140984784 no 518 0.150781354811404 173 728868 YDL195W SEC31
SGTC_818 4072-2707 53.5 µM 1.0316193887802 0.149559350370948 no 519 0.151125226934087 163 882871
SGTC_2421 5690543 90.72 µM 1.03009408350584 0.149923654716486 no 520 0.151482921164538 190 3397993
SGTC_813 k007-0158 173 µM 1.02914452752188 0.150150745564813 no 521 0.151705882417301 177 6523916
SGTC_214 4373-3496 70 µM 1.02807826869035 0.150406019611114 no 522 0.151956506000998 205 3779166
SGTC_1841 st054148 70 µM 1.02415967545868 0.151346656539101 no 523 0.152879930856545 183 675442
SGTC_222 nsc-310342 10.666 µM 1.02415040773031 0.151348885834088 no 524 0.152882119217823 163 432556
SGTC_2321 7390090 138.78 µM 1.02309756377541 0.151602283125869 no 525 0.153130859360314 150 649046
SGTC_633 0437-0093 97.7 µM 1.02020315711263 0.152300358216767 no 526 0.153816060321459 177 2831118
SGTC_1156 4092-0367 4.88 µM 1.01875226474905 0.152651087130574 no 527 0.154160296551862 205 1357585
SGTC_2178 5812956 200 µM 1.01803317782202 0.152825112772412 no 528 0.154331094599488 188 5403383
SGTC_1610 st001799 48.1 µM 1.01583742743261 0.153357318481901 no 529 0.154853404922064 168 621897
SGTC_202 3594-0513 34.79 µM 1.01543639246263 0.153454653734647 no 530 0.154948926381753 173 708429
SGTC_772 k072-0172 35.3 µM 1.01499513984212 0.153561797489176 no 531 0.15505407213231 148 5861980
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 1.01478960641819 0.153611721460984 no 532 0.155103064614903 189 66535 A nucleotide analog.
SGTC_166 k072-0058 166.424 µM 1.0137918470136 0.153854229455587 no 533 0.15534104322558 187 5846229
SGTC_404 fumagillin 50 µM 1.01316337706696 0.154007110693146 no 534 0.155491065119283 185 12015870 A methionine aminopeptidase binder.
SGTC_1129 3453-1384 223 µM 1.01136604225571 0.154444883916086 no 535 0.155920633842069 182 1084452
SGTC_1346 1488-2224 62.4 µM 1.0078468950813 0.155304415532519 no 536 0.156763984491032 181 3722427
SGTC_2315 7733312 200 µM 1.00769398090779 0.155341835380482 no 537 0.156800697738102 173 726316
SGTC_1158 4092-0494 91.8 µM 1.00657332047178 0.155616255390541 no 538 0.157069930377918 165 1148199
SGTC_3240 9133527 49.47 µM 1.00459127471976 0.156102388218189 no 539 0.157546850199768 178 17617455
SGTC_1284 0929-0043 16 µM 1.00254708862868 0.15660480925909 no 540 0.158039717961666 189 1239883
SGTC_45 0kpi-0036 14.9 µM 1.00055097241845 0.157096441813804 no 541 0.158521971463773 187 2795021
SGTC_2730 imipramine 71.33 µM 1.00017712242849 0.157188631766734 no 542 0.158612399284701 174 3696 A tricyclic antidepressant.
SGTC_3146 9095609 49.47 µM 0.998134365095701 0.157692995912673 no 543 0.159107104061571 173 17173999
SGTC_1077 5-fluorocytosine 377 nM 0.995795025458123 0.158271891702761 no 544 0.159674873901927 211 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_546 peri-Naphthalide 147 µM 0.995224875315739 0.158413192820551 no 545 0.159813452986422 195 223824 A penicillin ester.
SGTC_2024 5144227 134 µM 0.993823959168257 0.1587607352185 no 546 0.160154289779589 172 3475211
SGTC_2114 5491910 81.25 µM 0.993213415131542 0.158912356611708 no 547 0.16030298105791 182 2849228
SGTC_341 1486-1430 230 µM 0.992942854584502 0.158979577459197 no 548 0.16036890194106 223 2054753 YPL210C SRP72
SGTC_3098 9119039 49.47 µM 0.989779195357579 0.159766972005267 no 549 0.161141027932877 173 17161528
SGTC_3166 9102297 49.47 µM 0.989724717975244 0.1597805530408 no 550 0.161154344948817 182 25237072
SGTC_2041 5107442 45.335 µM 0.989654893036503 0.159797961276989 no 551 0.161171414730474 209 793005
SGTC_2740 felodipine 17.08 µM 0.989303588988515 0.159885564623268 no 552 0.161257314312622 150 3333 L-type calcium channel blocker
SGTC_3041 9091929 49.47 µM 0.988582217434289 0.160065548747552 no 553 0.161433795056355 171 25236887
SGTC_1219 1469-0211 33.1 µM 0.988266106110599 0.160144461095072 no 554 0.161511170134938 206 6822282
SGTC_899 1083-0020 478 µM 0.988128727577354 0.160178763467656 no 555 0.161544804036439 211 767123
SGTC_3149 9097855 49.47 µM 0.987234325624206 0.160402206238666 no 556 0.161763888942401 170 25236625 YMR079W SEC14
SGTC_1053 3366-3204 134 µM 0.986745137039564 0.16052450324258 no 557 0.161883798188057 193 3632071 YPR165W RHO1
SGTC_609 0986-0026 86.3 µM 0.984013985667765 0.16120840936841 no 558 0.162554318211005 192 2848610
SGTC_1192 1488-0095 21.4 µM 0.983466457094997 0.161345744106068 no 559 0.16268895809696 182 915875
SGTC_905 2-aminofluorene 215 µM 0.983131900090355 0.16142969745327 no 560 0.162771262953146 184 1539 An established DNA mutagen. YPR165W RHO1
SGTC_125 0133-0007 11.75 µM 0.980649089044526 0.162053621133457 no 561 0.163382908944339 200 26541
SGTC_863 0466-0191 129 µM 0.980197491372124 0.162167274996336 no 562 0.163494321299633 210 765160 YPR165W RHO1
SGTC_472 calcifediol 10 µM 0.979882692477668 0.162246531320052 no 563 0.163572013601732 166 5283731 A vitamin D metabolite.
SGTC_2751 anetholtrithion 17.25 µM 0.979188429057443 0.162421413834462 no 564 0.163743442392314 173 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_2750 bromebric acid 70.15 µM 0.978462466487306 0.162604412416254 no 565 0.163922823080021 181 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_3345 9148410 3.559 µM 0.97709695468055 0.162948990059689 no 566 0.164260577637202 183 4903596
SGTC_2745 rifampicin 24.3 µM 0.976471127898599 0.163107071733829 no 567 0.164415524395189 125 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_965 1291-5240 308 µM 0.976317351266825 0.163145930427407 no 568 0.164453612031289 196 2834598
SGTC_673 1082-0474 110 µM 0.973532114674651 0.163850788962409 no 569 0.165144453541394 215 3098046
SGTC_994 3910-0338 138 µM 0.972920998316194 0.164005707891855 no 570 0.165296283906903 209 3479481
SGTC_398 bronopol 33.3 µM 0.970290441847511 0.164673642491301 no 571 0.165950870120374 208 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_2084 5306078 60.6385 µM 0.967747998475608 0.165320876487253 no 572 0.166585120109234 196 679340
SGTC_1490 4089-0339 670 nM 0.965270951484367 0.165953043354099 no 573 0.167204558699145 210 742542
SGTC_3335 9143315 29.6265 µM 0.964617540742426 0.166120060287319 no 574 0.167368205214202 182 4899691
SGTC_2919 7978188 46.38 µM 0.962297312933051 0.166714005879619 no 575 0.167950139189955 184 2980291
SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.961783621399283 0.166845688712664 no 576 0.168079153521081 188 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_385 1494-0393 12.4 µM 0.960900482611396 0.167072234709622 no 577 0.168301104060087 205 3090647
SGTC_2083 5306046 65.942 µM 0.958790510913703 0.167614295010617 no 578 0.168832145243438 192 539837
SGTC_1978 st071761 42 µM 0.95830393912895 0.167739457833367 no 579 0.168954759036148 192 5147680
SGTC_2311 7694451 200 µM 0.958123162442472 0.167785975079674 no 580 0.169000328477925 223 2163142
SGTC_1242 0402-0103 60.1 µM 0.958066040709304 0.16780067530426 no 581 0.169014729130081 188 432868
SGTC_2040 5100729 123 µM 0.957539363201829 0.167936254337841 no 582 0.169147544089756 184 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_346 4513-0042 7.16 µM 0.955375893559353 0.168493921199079 no 583 0.16969382011057 194 2827372
SGTC_331 k048-0133 24.5 µM 0.953579213382528 0.168957946476792 no 584 0.170148340898032 195 6813582
SGTC_744 1594-0068 283 µM 0.952462401579386 0.169246796716429 no 585 0.170431262669338 212 668392
SGTC_1162 k048-0130 20.1 µM 0.950600778791255 0.169728987772295 no 586 0.170903536573473 188 6797406
SGTC_1607 st000305 50.6 µM 0.950167403221124 0.169841365510926 no 587 0.171013599385955 186 5457690
SGTC_672 1441-0018 53.7 µM 0.949863490475734 0.169920200960654 no 588 0.171090810038223 175 251141
SGTC_2089 5281248 129.67 µM 0.948762715820849 0.170205939992277 no 589 0.171370654294419 184 2737878
SGTC_1762 st045503 25.4615 µM 0.948488958817952 0.17027704959844 no 590 0.171440295528739 190 4645554
SGTC_2567 aureobasidin a 60 nM 0.944379576277808 0.171346766631319 no 591 0.172487857220874 221 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_2329 6138490 200 µM 0.942969691601657 0.171714762597496 no 592 0.172848202881944 190 720019
SGTC_2900 5328528 85.29 µM 0.940576416924844 0.17234058945284 no 593 0.173460985995428 212 795359
SGTC_1946 st076057 65.1 µM 0.939293242582924 0.172676730244054 no 594 0.173790103537677 178 953009
SGTC_2741 miltefosine 3.04 µM 0.939181319526712 0.172706069451595 no 595 0.173818829168055 160 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_2053 5265679 138 µM 0.938283515873921 0.172941532250205 no 596 0.17404936437254 226 764595
SGTC_1482 3346-2049 8.48 µM 0.932467712583302 0.174471766638645 no 597 0.175547432612694 177 3826804
SGTC_2638 epoxomicin 18 µM 0.931576968647022 0.174706893348516 no 598 0.175777595125718 180 9915668 A protesome inhibitor.
SGTC_1961 st076550 68.7 µM 0.930216216127182 0.175066474854102 no 599 0.176129573723769 213 1579337
SGTC_2845 9003024 42.97 µM 0.929160352732369 0.175345812072195 no 600 0.176402995453924 190 2990173
SGTC_1022 4477-0945 21.3 µM 0.926065861283142 0.176166111518967 no 601 0.177205877033799 189 4648966
SGTC_1383 3049-0032 20.7 µM 0.925537132575299 0.176306511493397 no 602 0.177343288897452 218 712864
SGTC_1838 st055369 84.5 µM 0.924445711981144 0.176596553967616 no 603 0.177627152065111 188 676036
SGTC_1832 st054113 55 µM 0.923154029593771 0.176940205179146 no 604 0.177963470750842 187 1251267
SGTC_2285 7945142 200 µM 0.922636961569236 0.177077889135705 no 605 0.178098213561963 196 2970608
SGTC_49 0717-0965 32.132 µM 0.920959399331514 0.177525053292023 no 606 0.178535812347605 213 5889349 YGL099W LSG1
SGTC_353 1988-1175 58.3 µM 0.919221820960644 0.177988965822007 no 607 0.178989779917715 211 2788357
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 0.918740444743012 0.178117622586535 no 608 0.179115674816928 205 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1845 st056753 3.01 µM 0.918275319669149 0.178241991604971 no 609 0.179237372437233 203 5375839
SGTC_785 1270-0111 65.3 µM 0.917768183036073 0.178377656374992 no 610 0.179370121414735 206 6741994
SGTC_2749 bexarotene 57.39 µM 0.917220942720068 0.178524122290239 no 611 0.179513437326796 211 82146 An retinoic acid receptor inhibitor.
SGTC_2935 9038016 29.96 µM 0.915722153887275 0.178925652719145 no 612 0.179906321175775 205 6463195
SGTC_860 0443-0016 25.1 µM 0.914073149334883 0.1793680825318 no 613 0.180339205124433 225 5337942
SGTC_1191 1487-1166 10.6 µM 0.912955732814982 0.179668277298459 no 614 0.180632911857319 202 3955771
SGTC_1789 tunicamycin 25 nM 0.911088490730526 0.180170617315273 no 615 0.181124375063371 211 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_2463 5473429 200 µM 0.910722051054022 0.180269303156462 no 616 0.181220921217382 203 5399405
SGTC_2893 9048488 25.97 µM 0.908641494992168 0.180830260425052 no 617 0.18176969782231 199 6467338
SGTC_867 0518-0118 155 µM 0.907245692018017 0.181207207883096 no 618 0.182138442990889 219 6848158
SGTC_1481 3346-2004 36 µM 0.905438003342212 0.181696119103121 no 619 0.182616695092935 236 2770522
SGTC_2623 humulene 100 µM 0.903857087723271 0.18212437267723 no 620 0.183035593037373 185 6187145 An anti-inflammatory.
SGTC_3100 9120536 49.47 µM 0.903610545092985 0.182191215336189 no 621 0.183100973859887 190 16421196
SGTC_1769 st044406 64.4 µM 0.903505442176529 0.182219715508987 no 622 0.183128850608815 248 670903
SGTC_1583 clindamycin 39.6 µM 0.903070369009086 0.182337721515714 no 623 0.183244274477046 218 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_2937 9044753 11.33 µM 0.901915946835092 0.182651069769273 no 624 0.183550759755159 187 6465530 YGL099W LSG1
SGTC_3336 9143619 71.43 µM 0.899723201625059 0.183247178376047 no 625 0.184133786485383 200 45595730
SGTC_2961 9083290 32.55 µM 0.897490475017698 0.183855401250631 no 626 0.184728626872926 212 17741490
SGTC_3127 9126946 49.47 µM 0.897305809411432 0.183905762725323 no 627 0.184777878697273 193 27243249
SGTC_2177 5811945 192 µM 0.896372718518028 0.184160363953116 no 628 0.185026866458532 202 5343475
SGTC_1736 st036774 51 µM 0.896136675452763 0.184224804922351 no 629 0.1850898856618 230 1272247
SGTC_730 1436-0052 41.2 µM 0.893205487380585 0.185026203081589 no 630 0.185873570015026 188 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_87 0100-0052 35.5 µM 0.893014162127118 0.185078587337943 no 631 0.185924794301483 226 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_2237 6667747 47.222 µM 0.890257165021058 0.185834467147035 no 632 0.186663907941817 207 729940 YDL015C TSC13
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.887389407134237 0.186622742401574 no 633 0.187434642288404 237 368090
SGTC_1273 0849-0096 14.1 µM 0.887200666743242 0.186674694947212 no 634 0.187485436769223 224 5286025
SGTC_1916 st067606 49.2 µM 0.880619408681835 0.188491843300815 no 635 0.189261925008904 208 19590279
SGTC_1306 1185-0270 9.02 µM 0.880018248514003 0.188658371345483 no 636 0.189424711951418 216 1548076
SGTC_606 k015-0008 38.6 µM 0.879127660157169 0.188905240857924 no 637 0.189666030897853 233 1970475
SGTC_1649 st011737 51.3 µM 0.878512859981118 0.189075778446417 no 638 0.189832730972321 208 1761035
SGTC_1337 1486-1011 40.3 µM 0.875536994046439 0.189902584577895 no 639 0.19064089526181 216 X1337
SGTC_727 3032-0951 202 µM 0.874660768354498 0.190146455605955 no 640 0.190879256213926 205 3652836
SGTC_997 3996-0078 137 µM 0.87081425691572 0.191219291096441 no 641 0.191927789748906 208 735687
SGTC_751 0833-0568 350 µM 0.870808301822709 0.191220954910862 no 642 0.191929415796281 221 6954252
SGTC_226 1,3-diallylurea 8.28947 mM 0.869979686141165 0.191452551291145 no 643 0.192155752801541 213 74537 YKL182W FAS1
SGTC_217 ketoconazole 989 nM 0.868364573708881 0.191904465618667 no 644 0.192597391090045 210 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_687 k029-0044 34.9 µM 0.867550859564892 0.192132392943595 no 645 0.192820128889152 187 5829338
SGTC_42 0133-0086 60.653 µM 0.865805857250261 0.192621739078853 no 646 0.193298318298479 256 162923 Model of phenazepam hydroxylation.
SGTC_1059 3448-6867 171 µM 0.865349739310712 0.192749772424358 no 647 0.19342342918267 236 3934407
SGTC_3158 9100007 49.47 µM 0.864285213844137 0.193048789377574 no 648 0.193715615370479 220 19297233
SGTC_2833 9001315 45.46 µM 0.86358468450422 0.193245717075564 no 649 0.19390804026371 205 2989378
SGTC_885 0865-0106 16.8 µM 0.863414822558109 0.193293485889319 no 650 0.193954716332128 215 2793380
SGTC_3228 9131799 49.47 µM 0.863311294243262 0.19332260380075 no 651 0.193983168055382 226 17015818
SGTC_904 1141-0088 396 µM 0.863203711570806 0.193352864858494 no 652 0.194012736694387 205 1378119
SGTC_2082 5219693 150 µM 0.861394347634104 0.193862239154887 no 653 0.194510444052456 208 2834649
SGTC_3171 9103192 49.47 µM 0.860857058996156 0.194013654650682 no 654 0.194658387216929 231 13018434
SGTC_2293 7624732 200 µM 0.859567880216312 0.194377257126397 no 655 0.195013643478351 208 894453
SGTC_444 curcumin 90.4 µM 0.858282136253372 0.19474030374591 no 656 0.195368345532549 215 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_960 1222-0186 7.7 µM 0.857935251984693 0.194838321666201 no 657 0.195464108629805 214 3126296
SGTC_528 3492-0019 172 µM 0.857628802109407 0.194924939134106 no 658 0.195548732862644 237 2869262
SGTC_21 0849-0113 22.993 µM 0.855690226341526 0.195473416226363 no 659 0.196084573878917 229 1560156
SGTC_1627 st003713 25.6 µM 0.85462750431347 0.195774487249117 no 660 0.196378698029244 215 16195070 YER133W GLC7
SGTC_552 k242-0005 476 µM 0.854222073419773 0.195889420663398 no 661 0.19649097750042 243 4088318
SGTC_892 0929-0076 29 µM 0.853579637259824 0.196071625237517 no 662 0.196668972521181 214 5751038
SGTC_1365 1672-3266 55.4 µM 0.853202073974871 0.196178755816005 no 663 0.196773626732064 228 6415873
SGTC_2603 homopterocarpin 100 µM 0.852339951406837 0.196423509258114 no 664 0.197012719041462 217 101795 A weak amylase inhibitor.
SGTC_1767 st044992 70.3 µM 0.851440562981356 0.196679039480844 no 665 0.197262333598809 239 9600693
SGTC_951 1171-0579 82.7 µM 0.85092732885807 0.196824947461672 no 666 0.197404861322159 235 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_405 ebelactone b 50 µM 0.846928446128297 0.197964038260979 no 667 0.198517502920259 200 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_3266 9136860 49.47 µM 0.846563850573514 0.198068091821415 no 668 0.198619135140729 230 4871271 YPR165W RHO1
SGTC_3230 9131665 49.47 µM 0.846313975907025 0.198139423742687 no 669 0.198688806652459 218 15943720
SGTC_1590 st077108 57.8 µM 0.845193281651695 0.198459539961024 no 670 0.19900146638874 195 5489485
SGTC_504 lovastatin 124 µM 0.844523601821934 0.198650976820032 no 671 0.199188440151386 218 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_74 000s-0487 160.283 µM 0.843341328887016 0.198989216942263 no 672 0.199518787452185 218 677548
SGTC_2960 9079389 5.97 µM 0.841728475845454 0.199451202312816 no 673 0.19996997760238 197 16457355
SGTC_756 0508-1999 28.3 µM 0.841495602530772 0.199517959810716 no 674 0.200035173767223 226 6753853
SGTC_2946 9065502 71.43 µM 0.840884597852373 0.199693179670626 no 675 0.200206293873529 178 16489101
SGTC_723 4182-0001 115 µM 0.838846231708304 0.200278398050821 no 676 0.200777801778144 209 744821 YLR208W SEC13
SGTC_3183 9108214 49.47 µM 0.838708127038 0.200318085375784 no 677 0.200816558327857 191 4974831
SGTC_2027 5150920 200 µM 0.838436214119002 0.200396239165877 no 678 0.20089287883618 220 786715
SGTC_797 k781-0471 270 µM 0.838338830435716 0.200424233845494 no 679 0.200920216717153 230 23738129
SGTC_1085 doxorubicin 7.67 µM 0.836994305980956 0.200810981475257 no 680 0.201297884326666 240 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2888 9058547 12.99 µM 0.836318185552055 0.201005634212205 no 681 0.201487962577473 193 16476514
SGTC_2706 st078239 82.5 µM 0.835797746195679 0.201155543971925 no 682 0.20163434731924 237 15434492
SGTC_702 1488-0190 94 µM 0.835741997744825 0.201171605988157 no 683 0.201650031544549 195 949357
SGTC_2550 chrysin dimethyl ether 71.87 µM 0.835104615036888 0.201355300750477 no 684 0.201829404230141 216 88881 An O-methylated flavonoid and antioxidant.
SGTC_3310 9130229 44.1445 µM 0.834858685805637 0.201426204838338 no 685 0.20189863934018 214 7761258
SGTC_140 0062-0056 502.533 µM 0.834440717434913 0.20154674401272 no 686 0.202016340299398 212 3758964
SGTC_1089 terbinafine 2.25 µM 0.833768675295315 0.201740646883694 no 687 0.202205675157829 222 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_365 0121-0052 13.6 µM 0.833330907271109 0.201867015217507 no 688 0.202329064900086 199 3101739
SGTC_1974 st069448 26.9 µM 0.830825221785864 0.202591230547678 no 689 0.203036186083605 220 6323587 YNR016C ACC1
SGTC_3059 1327-0034 3 µM 0.830285437363412 0.202747446874945 no 690 0.203188709819241 224 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_708 3448-5400 146 µM 0.830142730997531 0.202788758841571 no 691 0.203229044952714 242 3462195
SGTC_2659 sanguinarine 24.21 µM 0.828810913438838 0.203174548208609 no 692 0.203605705892272 236 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_1289 0976-0073 69.1 µM 0.828022314028849 0.203403189216935 no 693 0.203828931485511 221 3391136
SGTC_1562 morin hydrate 59.1 µM 0.826892149192807 0.2037311288329 no 694 0.204149096805903 220 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_653 0203-0016 55.2 µM 0.825341368294793 0.204181631148142 no 695 0.204588905951874 232 295302
SGTC_2502 avocadyne acetate 18.59 µM 0.822641336493145 0.204967405429575 no 696 0.205355992262493 221 3952079
SGTC_1479 0549-0158 134 µM 0.822453863351271 0.205022031292494 no 697 0.205409317236721 221 5440202
SGTC_2189 6047310 154.431 µM 0.822370228544131 0.205046403566475 no 698 0.205433109024429 229 711535
SGTC_1525 8-methoxypsoralen 92.5 µM 0.821817719966781 0.205207455035993 no 699 0.205590323532978 239 4114 Related to psoralen; DNA damaging agent.
SGTC_7 0192-1582 4.227 µM 0.820722009906059 0.205527067275261 no 700 0.205902315438726 260 252616
SGTC_24 0417-1663 219 µM 0.820606413669764 0.205560803250423 no 701 0.205935246620726 239 4329390
SGTC_255 tunicamycin 200.472 nM 0.820176592649395 0.205686272426458 no 702 0.206057721904607 223 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 0.816653756305834 0.206716336370444 no 703 0.207063162693941 231 688662
SGTC_470 aa-861 153 µM 0.815918100074574 0.206931824329026 no 704 0.207273489603717 234 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_207 4185-0010 4.486 µM 0.815783346100973 0.206971310778822 no 705 0.207312029962157 232 3761753
SGTC_1385 3091-4834 14.1 µM 0.815358175590774 0.207095926117534 no 706 0.207433658778776 208 4072814
SGTC_2065 5221596 34.26 µM 0.815305362115325 0.207111408580257 no 707 0.20744877011031 226 788581
SGTC_755 1995-0008 37.3 µM 0.81527857557496 0.207119261413851 no 708 0.20745643469636 206 689533
SGTC_1805 st050013 60.3 µM 0.814957571548071 0.207213381751934 no 709 0.207548298436738 233 4037144
SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.813751103879532 0.207567351554969 no 710 0.207893775771458 250 688801
SGTC_819 1013-0258 27.7 µM 0.813323646979692 0.207692850319392 no 711 0.208016261362365 228 5753198
SGTC_2048 5246248 200 µM 0.813253214462848 0.207713533181751 no 712 0.20803644752748 228 677046
SGTC_1836 st055642 81 µM 0.813250438797062 0.207714348294871 no 713 0.208037243065086 254 8571
SGTC_274 sirtinol 40.1 µM 0.812939526617427 0.207805663969108 no 714 0.208126365422832 217 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_2969 9091408 28.7 µM 0.811751515178781 0.208154804178564 no 715 0.2084671140196 211 4286311
SGTC_1251 0490-5699 265 µM 0.810326150364656 0.208574155775402 no 716 0.208876374781909 242 3883818
SGTC_1499 4480-0877 67.3 µM 0.810131549434005 0.208631447252316 no 717 0.208932286669951 223 2861909
SGTC_873 0591-4978 488 µM 0.808731431342858 0.209043922344701 no 718 0.209334822307196 254 3305145
SGTC_1493 4348-0038 111 µM 0.807904341276501 0.20928780873713 no 719 0.20957282599075 260 800424
SGTC_1118 chelidonine 707.474 nM 0.807209255777858 0.209492900021662 no 720 0.209772967032348 232 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_2473 5854593 8.94 µM 0.80676272657637 0.209624714867507 no 721 0.20990159870479 236 2872951
SGTC_2929 9013348 24.6 µM 0.806551953306212 0.209686951808277 no 722 0.209962332265551 223 2995952
SGTC_2777 climbazole 1.536 µM 0.806278240782968 0.209767789609744 no 723 0.210041216956794 243 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_858 0438-0351 2.77 µM 0.805544537855528 0.209984570575093 no 724 0.210252758011323 245 2799119
SGTC_973 1325-0077 65.9 µM 0.805061481485331 0.210127366973618 no 725 0.210392100987715 224 2835149
SGTC_179 1273-0063 6.77 µM 0.805041925424626 0.210133149146129 no 726 0.21039774329228 227 3108139
SGTC_614 0462-0418 107 µM 0.804966333179981 0.210155500507834 no 727 0.210419553963085 225 5188303
SGTC_429 1112-0049 25.5 µM 0.80476413053355 0.210215295309934 no 728 0.210477902124005 233 2836170
SGTC_2009 4012297 12.05 µM 0.800817094894867 0.21138450150361 no 729 0.21161877046836 216 45595307
SGTC_1565 sinapyl alcohol 95.1 µM 0.800557771099129 0.211461452514652 no 730 0.211693853060832 240 5280507 A phenol propionate derived from cinnamic acid.
SGTC_2519 cryptotanshinone 88.04 µM 0.800400951959526 0.211507994541715 no 731 0.211739264817391 230 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_1906 st060206 94.7 µM 0.799758181347953 0.211698823763792 no 732 0.21192545817998 247 5133468
SGTC_2124 5246320 200 µM 0.799579300244787 0.21175194887323 no 733 0.21197729225624 247 579342
SGTC_3159 9100096 49.47 µM 0.798363369248249 0.212113269550032 no 734 0.212329826993315 226 25236875
SGTC_3047 9092122 49.47 µM 0.795999849483686 0.212816633088379 no 735 0.213016061444841 232 17173831
SGTC_3203 9113543 49.47 µM 0.795027735483742 0.213106320690106 no 736 0.213298684326914 232 17018012
SGTC_322 k048-0136 19.3 µM 0.795000193287716 0.213114531546774 no 737 0.213306694858263 235 6823282
SGTC_910 3454-3003 490 µM 0.794568672444985 0.213243200276228 no 738 0.21343222377307 250 820824
SGTC_2856 9022925 19.48 µM 0.792485166331496 0.213865086786598 no 739 0.21403891883702 241 4944862
SGTC_1166 k206-0078 225 µM 0.792184404542249 0.213954945539587 no 740 0.214126580337585 229 5404595
SGTC_2412 st077135 33.4 µM 0.791939498954927 0.214028132339567 no 741 0.214197977146592 249 13258915
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.788259029439197 0.215129745752766 no 742 0.21527260364828 234 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2466 5983409 37.09 µM 0.787939386051291 0.215225574364902 no 743 0.215366080819288 228 2879657
SGTC_519 k048-0011 62.8 µM 0.786372690917434 0.21569562540067 no 744 0.215824588839049 235 6836379
SGTC_505 gw-5074 63.9 µM 0.785927281420611 0.215829368904406 no 745 0.215955045313219 250 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_872 0588-0139 234 µM 0.785473505251165 0.215965674087673 no 746 0.216087999281757 222 2047100
SGTC_375 3970-0961 9.27 µM 0.783591835901144 0.216531421423533 no 747 0.216639823896257 248 2898222
SGTC_1752 st044819 83.042 µM 0.782977652141895 0.216716268878173 no 748 0.21682011776633 237 441209 YML126C ERG13
SGTC_1160 4092-0570 10.5 µM 0.780699398670186 0.217402738691331 no 749 0.217489657190941 247 4994975
SGTC_1644 st010134 20.9 µM 0.779836816447153 0.217662974142296 no 750 0.217743466382466 259 3818134
SGTC_2191 5911152 200 µM 0.779679705183069 0.217710392932776 no 751 0.217789713735772 237 2875902
SGTC_1334 1486-0610 236 µM 0.779147312483773 0.217871122207222 no 752 0.217946471251704 229 3742339
SGTC_153 4077-0274 519.67 µM 0.778935972972726 0.217934944543134 no 753 0.218008716015927 254 3121976
SGTC_2571 chrysanthemic acid 100 µM 0.778291177157006 0.218129732786413 no 754 0.218198687810636 263 2743 An insecticide.
SGTC_1698 5-fluorocytosine 1.055 µM 0.778219591851987 0.218151364386139 no 755 0.218219784382591 254 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_2803 7707263 71.43 µM 0.775271931916833 0.21904315928338 no 756 0.219089495603117 225 2199229
SGTC_720 r052-1644 49.9 µM 0.774296252294326 0.21933880584786 no 757 0.21937780970955 243 1422863 YOR257W CDC31
SGTC_2179 6298986 200 µM 0.77382725607915 0.219481000786335 no 758 0.21951647601434 233 738374
SGTC_1417 3966-0327 90.4 µM 0.773080753279851 0.219707442125452 no 759 0.219737295437039 243 651118
SGTC_1834 st055981 52.8 µM 0.773048096349152 0.219717351216822 no 760 0.219746958438112 236 471719 YDL150W RPC53
SGTC_3117 9124945 49.47 µM 0.772419165714801 0.219908237666884 no 761 0.219933103039644 224 17592065
SGTC_1930 st074634 34.3 µM 0.770557135054032 0.220473939397143 no 762 0.220484738455477 243 684253 YOR116C RPO31
SGTC_676 falcarinol 140 µM 0.769557438963814 0.220777999841058 no 763 0.220781229988087 255 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_1097 itavastatin 7.23 µM 0.766686110688244 0.221652656728846 no 764 0.221634081803689 244 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_2111 5486399 200 µM 0.764744690297764 0.222245167700343 no 765 0.222211794401133 237 689674
SGTC_1027 k015-0025 8.67 µM 0.764339290188262 0.222369007580053 no 766 0.222332538538636 239 3598955
SGTC_774 k060-0086 136 µM 0.763153064168761 0.222731596809197 no 767 0.222686058328044 236 5911235
SGTC_301 4119-0100 24.5 µM 0.762873637442771 0.222817057130208 no 768 0.222769379849438 261 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_2405 ticlatone 3.52 µM 0.761651426423527 0.223191079637337 no 769 0.223134036477312 225 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_1252 0493-0875 34.8 µM 0.761266180674038 0.223309047053434 no 770 0.22324904809544 221 3960963
SGTC_1451 4152-0210 104 µM 0.760652974846822 0.223496892076246 no 771 0.223432184704257 250 659563
SGTC_1423 4048-0112 5.59 µM 0.758832252022668 0.224055168436103 no 772 0.223976454921508 236 X1423
SGTC_2014 4013930 200 µM 0.758345615656504 0.224204516619107 no 773 0.224122053014795 248 64556
SGTC_787 4152-0075 138 µM 0.755916381230969 0.224950890945679 no 774 0.22484966587618 245 9566539
SGTC_2302 7771753 200 µM 0.754041800369836 0.225527811183682 no 775 0.225412061220793 254 2203047
SGTC_579 4491-1009 110 µM 0.753933958025527 0.225561026153688 no 776 0.225444439344201 285 1271041
SGTC_192 3455-0609 60.9 µM 0.753147235375563 0.225803417034096 no 777 0.225680721227314 236 3769639
SGTC_1523 st012844 44.7 µM 0.752931345136713 0.225869959016553 no 778 0.225745585534407 232 4274103
SGTC_1441 4106-0040 13 µM 0.752067507074075 0.226136323282498 no 779 0.226005231513397 245 2904180
SGTC_3078 9116413 49.47 µM 0.751983496091214 0.226162237517607 no 780 0.226030491910257 266 17177322
SGTC_2947 9072639 7.68 µM 0.751199757356108 0.226404072337697 no 781 0.226266223113771 270 16488146
SGTC_357 1325-0123 420 µM 0.749208173419477 0.227019263250004 no 782 0.226865871792863 260 1098503
SGTC_612 0302-0167 22.4 µM 0.74815980631014 0.227343477221783 no 783 0.227181885846787 276 235821
SGTC_691 1548-0686 185 µM 0.744770424099346 0.22839344761563 no 784 0.228205258644594 266 46495133
SGTC_2022 5136654 200 µM 0.743397739627711 0.228819454891985 no 785 0.228620456198814 268 1713771
SGTC_1660 st012960 28.1 µM 0.743203562854231 0.228879752885878 no 786 0.228679223317043 253 24207266
SGTC_1696 st025591 34.7925 µM 0.740076747357683 0.229851954545807 no 787 0.229626713500117 249 2787147
SGTC_1866 st057638 64 µM 0.739251397395519 0.230108960712087 no 788 0.229877178070997 242 688802
SGTC_2678 equilin 100 µM 0.739018358159482 0.230181556020838 no 789 0.229947924928343 227 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_871 0574-0004 149 µM 0.737387855590096 0.230689840910293 no 790 0.23044325932037 264 9551173
SGTC_2223 6903751 107.57 µM 0.736849162033634 0.230857908303912 no 791 0.230607041354162 252 5598863
SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.734408332740163 0.231620280567827 no 792 0.231349954885957 276 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_641 4092-0595 30 µM 0.732099041160871 0.232342858064223 no 793 0.232054059510976 252 786260
SGTC_1761 st044296 37 µM 0.730878282822331 0.232725339524861 no 794 0.232426751063348 268 1826700
SGTC_391 gliotoxin 8.33 µM 0.727486634081512 0.233789827157975 no 795 0.233463950125913 274 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_167 3672-0051 66.205 µM 0.726615728404905 0.234063600488189 no 796 0.233730695198929 245 3237971
SGTC_500 h-89 112 µM 0.726259124356758 0.234175751877747 no 797 0.233839966288457 261 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_2298 7976326 193.81 µM 0.725701004113774 0.234351339489289 no 798 0.234011043051457 234 2235818
SGTC_2687 chenodiol 100 µM 0.725241257418793 0.234496032970286 no 799 0.234152018105996 245 5702181 A cholesterol synthesis inhibitor.
SGTC_1293 1000-1278 195 µM 0.724601956293187 0.234697318722516 no 800 0.234348129214577 284 678847
SGTC_2350 9023895 38.85 µM 0.723287640984496 0.235111434517486 no 801 0.234751592110545 254 2997209
SGTC_2965 9082772 38.63 µM 0.719726458663826 0.236235521058363 no 802 0.235846716116451 203 16459634
SGTC_565 1418-0001 44.5 µM 0.717846129163304 0.236830238583784 no 803 0.236426083525421 270 2862145
SGTC_2384 9036245 200 µM 0.71728474117969 0.237007955891247 no 804 0.236599210216165 235 6462766
SGTC_176 1486-1328 72.834 µM 0.715201691331908 0.23766802231032 no 805 0.237242212051183 259 22310231
SGTC_1981 st071826 47 µM 0.714831552785178 0.237785415402113 no 806 0.237356567831127 247 11838600
SGTC_159 3970-0959 50 µM 0.713009807626848 0.238363663063359 no 807 0.23791984410719 260 6615653
SGTC_635 k038-0028 24.7 µM 0.71130138412592 0.238906639808353 no 808 0.238448747030638 276 4035102
SGTC_1075 aripiprazole 15.2 µM 0.711291957478301 0.238909637691545 no 809 0.238451667167604 255 60795 An atypical antipschotic. YIL048W NEO1
SGTC_2486 5283202 22.39 µM 0.710689736513933 0.239101199957056 no 810 0.238638260563399 262 1377751
SGTC_1005 4092-0690 4.4 µM 0.710022111713044 0.2393136648128 no 811 0.238845212179759 274 1529343
SGTC_2657 nystatin 74.44 µM 0.709372315409227 0.239520554929553 no 812 0.239046731513451 258 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.707516903598059 0.240111840837131 no 813 0.239622655949119 252 77254
SGTC_2739 tacrine 100.86 µM 0.707384438569691 0.240154085435938 no 814 0.239663802368691 249 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_3147 9097027 49.47 µM 0.706933651872103 0.240297876768287 no 815 0.239803855068393 292 25236841
SGTC_2294 7971431 200 µM 0.705443008583836 0.24077369399724 no 816 0.24026729347304 294 5741572
SGTC_630 4356-0227 183 µM 0.70500132967422 0.240914777455358 no 817 0.240404704341571 286 779312
SGTC_250 brefeldin a 552.239 µM 0.704873797408226 0.240955522864297 no 818 0.240444388908962 262 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.704756458688582 0.240993014837517 no 819 0.240480904673631 265 4213774
SGTC_1895 st058434 18.3 µM 0.704240189410782 0.241158010462218 no 820 0.240641603344603 290 5393175
SGTC_1295 1013-0063 9.78 µM 0.702073065341855 0.241851275778745 no 821 0.241316799331861 269 6826038
SGTC_3042 9091578 49.47 µM 0.701987111403943 0.241878794813308 no 822 0.241343600618392 256 25236497
SGTC_2140 5586273 200 µM 0.701828800643734 0.241929484072112 no 823 0.241392967708745 262 854421
SGTC_2434 5670830 169.91 µM 0.701479654156302 0.242041297070884 no 824 0.241501863753108 284 1549830
SGTC_38 0929-0051 58.268 µM 0.700305932781827 0.242417382802966 no 825 0.241868133738239 274 1379719
SGTC_193 1273-0060 1.558 µM 0.699578629445441 0.242650585306963 no 826 0.242095246238736 270 2847393 YHR072W ERG7
SGTC_3305 9127027 53.8275 µM 0.698535980409532 0.242985112004351 no 827 0.242421032260014 272 41905295
SGTC_624 k048-0052 28 µM 0.697506923885028 0.243315522102818 no 828 0.242742803911197 256 6835531
SGTC_468 gf-109203x 121 µM 0.69684504160063 0.243528167921187 no 829 0.242949887392639 241 2396 A protein kinase C inhibitor.
SGTC_526 4469-0568 170 µM 0.696781645831084 0.243548540623993 no 830 0.242969727076782 260 2901964
SGTC_2335 9018011 154.17 µM 0.695450670121129 0.24397647204247 no 831 0.24338645774969 251 6458208
SGTC_1380 2291-0730 164 µM 0.695088891078499 0.244092860258445 no 832 0.243499798081247 264 2999191
SGTC_2004 4023728 41.89 µM 0.694783966568473 0.244190981009368 no 833 0.243595348818123 295 360084 YDR527W RBA50
SGTC_1397 3532-0190 20.1 µM 0.694777436754555 0.24419308245132 no 834 0.243597395213313 247 5322280
SGTC_738 1315-0003 72.4 µM 0.694283529369594 0.244352061287667 no 835 0.243752209025836 289 6251474
SGTC_354 2783-3500 4.88 µM 0.693161646812032 0.244713379835728 no 836 0.244104057050121 269 6740761
SGTC_563 tetrahydrosecaminediol 614 µM 0.691415445271515 0.245276341205916 no 837 0.244652250285848 282 334274 A psychoactive constituent of the cannabis plant.
SGTC_1506 4226-2149 212 µM 0.690853326917061 0.245457711676344 no 838 0.244828859685592 279 991114
SGTC_473 2-arachidonoylglycerol 10 µM 0.69075534133079 0.245489334619823 no 839 0.244859652351493 271 5282280 An endocannabinoid.
SGTC_961 1252-1571 372 µM 0.689259139474935 0.245972476466518 no 840 0.245330103206955 286 6813498
SGTC_1234 0326-0494 15.5 µM 0.689187220932548 0.245995712686403 no 841 0.245352728790774 284 1547813
SGTC_548 1436-0017 110 µM 0.689074936031277 0.246031993260384 no 842 0.245388055879216 266 9677137
SGTC_978 1416-0512 87.4 µM 0.687313003812314 0.246601670054247 no 843 0.245942753016442 287 6814003
SGTC_309 k408-0051 1.48 µM 0.683601992115513 0.247803840601063 no 844 0.247113263197356 284 3640463
SGTC_642 0335-0876 158 µM 0.68312927637947 0.247957199719339 no 845 0.247262578678957 279 6812350
SGTC_431 k089-0097 107 µM 0.682485415816761 0.248166163334383 no 846 0.247466030801422 272 5499420
SGTC_1399 3562-5772 25 µM 0.679233440192637 0.249223018895163 no 847 0.24849498109083 283 23847490
SGTC_3308 9128332 17.569 µM 0.678128704718682 0.249582589400442 no 848 0.248845046015214 255 17332805 YDL196W YDL196W
SGTC_1547 harmine 94.2 µM 0.677839502171026 0.249676764857465 no 849 0.248936730900903 266 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_2692 st077426 47.7 µM 0.677559983222074 0.249767804895574 no 850 0.24902536291104 276 25238571
SGTC_2400 5203494 178.7 µM 0.675828482606826 0.250332151637975 no 851 0.249574774339864 291 6777674
SGTC_884 0851-0618 334 µM 0.675798618855873 0.250341891035357 no 852 0.249584255862237 291 9642473
SGTC_726 3448-4391 34.2 µM 0.675140458997982 0.250556586204386 no 853 0.24979326537257 283 1356692
SGTC_1802 st050112 57.9 µM 0.674837756237913 0.250655362159497 no 854 0.249889424812957 278 4662563
SGTC_2913 7966556 36.57 µM 0.674682294517617 0.250706099411207 no 855 0.249938817898711 265 2976516
SGTC_1241 0364-0022 50.8 µM 0.674392082198717 0.250800829082737 no 856 0.250031037623721 287 4563895
SGTC_2695 st077686 51.995 µM 0.672995482860031 0.251256965047465 no 857 0.250475082345904 272 2876092
SGTC_1896 st058441 89 µM 0.672861866025719 0.251300627918907 no 858 0.250517587325007 270 688759
SGTC_3017 9080681 49.47 µM 0.669692376991773 0.252337518257798 no 859 0.251526956076335 293 16451914
SGTC_106 0092-0003 11.579 µM 0.668148601417365 0.252843376130259 no 860 0.2520193703925 274 1072148
SGTC_864 0469-0573 172 µM 0.667394982036806 0.253090512717996 no 861 0.252259935148977 291 689425
SGTC_2997 9067075 71.4286 µM 0.667173295564949 0.253163235185268 no 862 0.252330723290881 283 27209819
SGTC_430 0958-0115 16.4 µM 0.666242295183726 0.253468762335739 no 863 0.252628121345075 291 6833180
SGTC_2243 6634756 200 µM 0.665036272392922 0.253864831691678 no 864 0.25301364666822 242 885676
SGTC_3233 9132340 49.47 µM 0.663156697798783 0.254482748917213 no 865 0.25361510067258 317 17682950
SGTC_136 0097-0015 404.482 µM 0.661995157235729 0.25486500336515 no 866 0.25398716266251 282 4861337
SGTC_1011 4112-3381 17.4 µM 0.661088939722435 0.255163441438755 no 867 0.25427763892627 298 2877139
SGTC_3140 9094243 49.47 µM 0.655398239288373 0.257041687585044 no 868 0.256105692409224 299 19291112
SGTC_2861 9024595 19.48 µM 0.653545365567322 0.257654786718686 no 869 0.256702376487086 260 16482810
SGTC_2776 terbinafine 19.92 µM 0.652990783026569 0.257838440589827 no 870 0.256881110282582 266 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1096 rimcazole 32.2 µM 0.65229369430945 0.258069382696514 no 871 0.257105863546623 297 18528119 A dopamine reuptake inhibitor.
SGTC_2785 7756463 72.73 µM 0.652176085184071 0.258108356601815 no 872 0.257143792809433 316 2201551
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.650926366095247 0.258522683261818 no 873 0.257547010263884 289 756377
SGTC_97 0535-0701 19.132 µM 0.65003083375921 0.25881979603823 no 874 0.25783615245369 272 2832013 YGL099W LSG1
SGTC_1824 st053723 68.6 µM 0.649883541706026 0.25886868036921 no 875 0.257883725039429 286 675225
SGTC_911 3456-4043 236 µM 0.648455862923477 0.259342755963075 no 876 0.25834507456324 291 914281
SGTC_2584 androsterone 48.74 µM 0.647701960694805 0.259593277899024 no 877 0.25858886792891 261 2754130 A steroid.
SGTC_1997 st073024 93.8 µM 0.646762104017522 0.259905767434915 no 878 0.258892961114572 283 686268
SGTC_105 0111-0055 734.78 µM 0.64668167902985 0.259932516656722 no 879 0.258918991428626 278 5179370
SGTC_2691 st077356 60.2 µM 0.644073373046342 0.260800804180023 no 880 0.259763927920482 314 2839272
SGTC_2376 9072922 81.32 µM 0.64355990805243 0.260971908844786 no 881 0.259930427599657 287 17087968
SGTC_303 1348-1668 34.2 µM 0.641824904951871 0.261550499899635 no 882 0.260493438566888 297 5380509
SGTC_1982 st072467 71.9 µM 0.640222936281892 0.262085310551012 no 883 0.261013836690529 300 3163533
SGTC_2564 betulinic acid 100 µM 0.638075253211494 0.262803184076638 no 884 0.26171234737077 305 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_837 0091-0265 12.5 µM 0.637724798454851 0.262920420651696 no 885 0.261826419944567 302 759367
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.636081070375517 0.263470648642756 no 886 0.262361791437919 316 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_2536 dehydroabietamide 32.04 µM 0.635540752918212 0.263651644898738 no 887 0.26253789822443 289 3983547
SGTC_2627 acetyl isogambogic acid 100 µM 0.635179676860822 0.263772633981734 no 888 0.262655618207983 303 6857789 A caspase activator and apoptosis inducer.
SGTC_1765 st044815 90.4 µM 0.634774526085946 0.263908425287552 no 889 0.262787739817738 304 645695
SGTC_409 arachidonic acid 100 µM 0.634739742691375 0.263920085034325 no 890 0.262799084433649 291 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_1186 1319-0216 26 µM 0.634237824402314 0.264088362364514 no 891 0.26296281313336 301 4565136
SGTC_2553 4-methylesculetin 85.09 µM 0.633986496283292 0.264172645269785 no 892 0.263044817433105 283 5319502
SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.632525963967798 0.264662705905135 no 893 0.263521624022152 306 23665772 A membrane-active detergent.
SGTC_1113 artemisinin 1.17947 µM 0.632199898792379 0.264772175491395 no 894 0.2636281317252 304 2240 An anti-malaria and mitochondrial poison.
SGTC_731 3966-0296 387 µM 0.632154161619481 0.26478753263475 no 895 0.263643073320382 280 660956
SGTC_1248 0469-0687 58.6 µM 0.631141298759305 0.265127737014335 no 896 0.263974069928775 289 4017482
SGTC_3039 9090270 49.47 µM 0.630237264559846 0.265431574984746 no 897 0.264269680855284 269 17173750
SGTC_1936 st074407 74.3 µM 0.628473797960555 0.266024768704518 no 898 0.264846803041713 298 809813
SGTC_2754 granisetron 64.02 µM 0.628135987055984 0.266138477899513 no 899 0.264957430046988 310 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_2001 4023502 57.655 µM 0.627892999350304 0.266220284246943 no 900 0.265037018674454 293 108941 YCR052W RSC6
SGTC_1915 st067105 30.6 µM 0.626728707430514 0.266612441401902 no 901 0.265418541380282 296 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_811 0416-0114 265 µM 0.626196804681435 0.266791694194636 no 902 0.265592931409412 308 6612453
SGTC_1266 0828-0227 32.9 µM 0.62514378826241 0.267146743372294 no 903 0.265938345473575 307 3913820
SGTC_968 1309-0633 340 µM 0.623806905793624 0.267597848023078 no 904 0.266377201920055 297 3761976
SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.623685291263743 0.267638903497022 no 905 0.266417142319148 299 1273210
SGTC_138 0850-0259 40.9225 µM 0.622766128171061 0.267949303573165 no 906 0.266719109964429 289 6813004
SGTC_2732 terfenadine 20 µM 0.622438840525544 0.268059871898604 no 907 0.266826673744158 312 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_2525 harmine 47.85 µM 0.621831460885078 0.268265125180646 no 908 0.267026348419206 280 5280953 A monoamine oxidase inhibitor
SGTC_939 1165-0479 45.3 µM 0.62160436085099 0.268341889951814 no 909 0.267101026415245 300 1377347
SGTC_704 1310-0270 142 µM 0.621088195139487 0.268516406318107 no 910 0.267270797967258 312 5718033
SGTC_1935 st074532 41.6 µM 0.620714880513676 0.268642660072596 no 911 0.267393618433904 295 2829742
SGTC_72 0744-0168 198.391 µM 0.619852027492876 0.268934588179162 no 912 0.267677605879262 325 677577
SGTC_956 1185-0240 191 µM 0.619428839902941 0.269077822957047 no 913 0.267816943495847 289 1416193
SGTC_1127 asiatic acid 681.4 nM 0.618569815562172 0.269368691508197 no 914 0.268099895877766 302 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_3221 9128209 49.47 µM 0.617939009186455 0.269582385025153 no 915 0.268307771755461 307 16460723
SGTC_3274 9138298 49.47 µM 0.615978734204778 0.270246994252332 no 916 0.268954277628224 300 17015756
SGTC_406 estrone 100 µM 0.61500379192454 0.270577842283937 no 917 0.269276108113676 305 5870 A steroid.
SGTC_557 1315-0110 16.2 µM 0.613949928728776 0.270935699648632 no 918 0.269624207648135 293 6833801
SGTC_2129 girgensonine 121.053 µM 0.613834083047666 0.270975051442851 no 919 0.269662486161851 299 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1276 0871-0068 94.2 µM 0.613342391587215 0.271142106586894 no 920 0.269824984472368 302 3414906
SGTC_3114 9122766 49.47 µM 0.612288612648643 0.271500307232998 no 921 0.270173411211181 269 17176985
SGTC_2348 9022543 33.42 µM 0.61153056964933 0.271758126969571 no 922 0.270424193425213 307 3162678 YDL140C RPO21
SGTC_3248 9135562 49.47 µM 0.611285570481988 0.271841480243481 no 923 0.270505270996215 300 17650701
SGTC_116 0155-0182 31.788 µM 0.611153790910574 0.27188631936552 no 924 0.270548885830593 261 771486
SGTC_1579 chlormadinone acetate 49.4 µM 0.610981319225949 0.271945009884458 no 925 0.270605973763602 324 45114258 A steroidal progestin.
SGTC_1658 st012944 20 µM 0.61057268940006 0.272084087981721 no 926 0.270741253785028 294 24207260
SGTC_1381 2324-0066 62.1 µM 0.610293430337389 0.272179154781069 no 927 0.270833724046525 310 10885928
SGTC_2139 5578692 56.4705 µM 0.609372151564632 0.272492898245 no 928 0.271138896214784 295 650991 YMR113W FOL3
SGTC_1447 4239-0816 81.9 µM 0.609352149999624 0.27249971181213 no 929 0.27114552360353 294 1341554
SGTC_1613 st002381 52.1 µM 0.608772082411059 0.272697349616828 no 930 0.271337760367122 297 551167
SGTC_2346 9031566 143.75 µM 0.608128799600057 0.272916608953982 no 931 0.271551026309863 302 4771086
SGTC_2219 9098279 200 µM 0.602916788074113 0.274696310865759 no 932 0.273282023570544 282 902349
SGTC_1603 st002045 67.8 µM 0.601464098521188 0.275193366487981 no 933 0.273765458501733 313 5887985
SGTC_3035 9091303 49.47 µM 0.60129875789675 0.275249967875199 no 934 0.273820508365667 307 25237002
SGTC_246 cycloheximide 667 µM 0.60111765562536 0.275311971554122 no 935 0.273880812322396 299 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_2424 5537928 59.2 µM 0.600678409093557 0.275462384196856 no 936 0.274027101169245 299 5382802
SGTC_2161 5662504 8.5105 µM 0.59895534197365 0.276052809796288 no 937 0.274601332560956 283 2859334
SGTC_1003 4049-0218 100 µM 0.598625784453443 0.276165806613052 no 938 0.274711228872779 307 295161
SGTC_967 1306-0166 352 µM 0.596916322162491 0.276752301402402 no 939 0.275281624625407 313 4437607
SGTC_2096 5468907 200 µM 0.594533883502594 0.277570702299794 no 940 0.276077543293007 303 759785
SGTC_3160 9100216 49.47 µM 0.593872616383182 0.277798066259143 no 941 0.276298657772951 300 17191039
SGTC_2238 6671620 73.2395 µM 0.593736123237952 0.277845008117173 no 942 0.276344309162545 279 729941
SGTC_1654 st012436 41.8 µM 0.593520345206339 0.277919225030098 no 943 0.276416485660022 307 4323132
SGTC_1605 st000082 49.1 µM 0.59224851517138 0.278356867804944 no 944 0.276842093161687 307 1114022
SGTC_1236 0330-0013 258 µM 0.591654096459132 0.278561525231658 no 945 0.277041120512552 319 4617066
SGTC_2471 5466956 24.79 µM 0.591352188262334 0.278665499806354 no 946 0.277142234297632 291 724419
SGTC_1938 st074717 56.4 µM 0.590899649729902 0.278821385548637 no 947 0.277293830352451 285 17250979
SGTC_1001 4048-4355 44.4 µM 0.590085728185946 0.279101863491206 no 948 0.27756658826075 322 21824233
SGTC_3021 9087658 49.47 µM 0.589214039421531 0.279402400111086 no 949 0.27785885018237 308 25237042
SGTC_3095 9117207 49.47 µM 0.586741383911863 0.280255764656832 no 950 0.278688704664469 301 17015229
SGTC_1112 tnp00069 1.16933 µM 0.586374864226688 0.2803823655398 no 951 0.278811815921816 302 145826
SGTC_2257 7960413 200 µM 0.585803213013416 0.280579876899731 no 952 0.279003882162416 304 2974689 YIL048W NEO1
SGTC_940 3232-1287 54.8 µM 0.583676699278913 0.281315199687241 no 953 0.279718923322832 324 1585493 YIL048W NEO1
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.582474860751741 0.281731191978307 no 954 0.280123434963388 294 4174840
SGTC_1719 st032227 49.2 µM 0.58119895158264 0.282173146593745 no 955 0.280553187095923 294 3125804
SGTC_790 1575-0012 79.1 µM 0.580951814174062 0.282258789621476 no 956 0.280636464866755 331 378741 YLR208W SEC13
SGTC_1359 1582-0056 520 nM 0.58015925529881 0.282533527421051 no 957 0.280903613685985 317 3661189
SGTC_2195 6536160 144.242 µM 0.579959177038629 0.282602904179677 no 958 0.280971073745339 298 3834386
SGTC_2456 5770359 74.46 µM 0.578053722307882 0.283264027016578 no 959 0.281613924824813 329 3118787
SGTC_1231 0242-0792 125 µM 0.577669225810645 0.283397523077041 no 960 0.28174372993849 324 3707635
SGTC_1189 1431-2119 7.28 µM 0.575356801456953 0.284201025586862 no 961 0.282525006694012 323 3107275
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.575145340061122 0.284274556806366 no 962 0.282596503088705 304 17037758
SGTC_340 k038-0059 454 µM 0.574637325422991 0.284451245289915 no 963 0.282768301489288 319 23733424
SGTC_465 cgp-37157 41 µM 0.574528012424007 0.284489271422577 no 964 0.282805275089947 302 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_1624 st003710 6.25 µM 0.574358537276894 0.284548230642499 no 965 0.282862602290731 341 24207033
SGTC_295 k015-0027 31 µM 0.57338203344085 0.284888063139543 no 966 0.283193026253847 313 3887424
SGTC_699 0375-0592 111 µM 0.57326577069936 0.284928536558785 no 967 0.283232378929182 288 762578
SGTC_2679 rapamycin 1 nM 0.572415884039036 0.285224482620118 no 968 0.283520128667912 288 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_2029 5175081 200 µM 0.572234858802545 0.285287537831254 no 969 0.283581437244824 301 1380876
SGTC_796 1234-0020 70.7 µM 0.571363365622284 0.285591191652015 no 970 0.283876678363158 304 46495034
SGTC_742 0kpi-0133 140 µM 0.570776157062595 0.285795879060325 no 971 0.284075693557497 317 2728852
SGTC_671 0560-0003 407 µM 0.570738150202127 0.28580912978209 no 972 0.284088577042832 309 3238678
SGTC_2430 5571206 200 µM 0.567026671499284 0.287104505867083 no 973 0.285348030483115 323 1731771
SGTC_2184 6075246 200 µM 0.565915525457712 0.28749285679795 no 974 0.285725603476786 307 2267320
SGTC_3211 9128781 49.47 µM 0.565380987188942 0.287679768965282 no 975 0.285907326887356 333 17194361
SGTC_397 arbidol 50 µM 0.56433706811076 0.28804496197711 no 976 0.286262379445432 308 131410 A RNA synthesis inhibitor.
SGTC_1154 4088-0362 150 µM 0.56323719925833 0.288429964381028 no 977 0.286636687709342 311 6618304
SGTC_228 caffeine 993.056 µM 0.55951747549641 0.289733825141964 no 978 0.287904304028086 295 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_2020 4017018 200 µM 0.556440362903379 0.290814519816495 no 979 0.288954926317767 331 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_683 panaxydol 45 µM 0.556266776001215 0.290875540367016 no 980 0.289014248017461 293 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_2226 7298446 200 µM 0.556003618926904 0.290968058697935 no 981 0.289104190409821 329 3283010
SGTC_435 c-PAF 6.7 µM 0.553473835306283 0.291858157268099 no 982 0.289969496068487 314 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_2137 5261020 140 µM 0.552524926544245 0.2921923554412 no 983 0.29029438063391 315 763655
SGTC_2647 atorvastatin 60.16 µM 0.551996329626839 0.292378600286891 no 984 0.290475433981983 307 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_377 3970-0964 33.1 µM 0.551554149159791 0.292534439709891 no 985 0.290626928827133 308 16481235
SGTC_360 0957-0399 1.01 µM 0.550109923878874 0.293043702512759 no 986 0.291121990209186 317 6752301 YPR165W RHO1
SGTC_1371 2421-0008 32.7 µM 0.548769979165076 0.293516561364188 no 987 0.291581657486757 315 2827552
SGTC_1440 4100-1550 40 µM 0.548294596303497 0.293684406147021 no 988 0.29174481859856 328 742806
SGTC_1263 0774-1208 64.8 µM 0.547477489821179 0.293973008018308 no 989 0.292025365609799 347 906585
SGTC_710 3448-4187 58 µM 0.542666328784914 0.29567496232574 no 990 0.293679780706361 314 3946412
SGTC_2533 agelasine 13.65 µM 0.542334223317568 0.295792611961204 no 991 0.293794141782784 336 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_1933 st074711 15.9 µM 0.541556205601648 0.29606831189036 no 992 0.294062134133036 311 17250958
SGTC_1427 4048-4900 550 nM 0.540852113912908 0.296317916855358 no 993 0.294304759624788 335 24132586
SGTC_2074 5212007 75.395 µM 0.540779440260421 0.29634368561847 no 994 0.294329807763426 314 758611
SGTC_2115 tiliquinol 12.7705 µM 0.539671751102713 0.296736579277569 no 995 0.294711712374365 347 71208 A bioactive hydroxyquinoline.
SGTC_2034 5197015 53.07 µM 0.539034095402351 0.296962861742077 no 996 0.294931664332402 342 780676
SGTC_1620 st003704 16.5 µM 0.538270350590668 0.297233992821953 no 997 0.295195208786003 318 2834414
SGTC_410 α-linolenic acid 100 µM 0.536997121714963 0.297686243194631 no 998 0.295634801116764 321 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_824 1304-0008 100 µM 0.536392123079154 0.297901248446338 no 999 0.295843787082527 327 768245
SGTC_2726 cimetidine 79.27 µM 0.535574049885952 0.298192088969468 no 1000 0.296126483706704 328 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_3010 9080089 71.4286 µM 0.534281122507072 0.29865201266941 no 1001 0.296573525401944 320 17027233
SGTC_2377 9073351 62.6 µM 0.534253161025838 0.298661962767136 no 1002 0.296583196759328 351 7337946 YHR072W ERG7
SGTC_2756 carbadox 75.1 µM 0.533851426111208 0.298804936839557 no 1003 0.296722165356867 331 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_3003 9075612 71.4286 µM 0.532000427817986 0.299464092976235 no 1004 0.297362849598794 342 6501993
SGTC_1014 4130-3005 69.3 µM 0.53193433764628 0.299487640429422 no 1005 0.297385737006239 330 743608
SGTC_9 0092-0002 10.449 µM 0.529539800898778 0.300341362138066 no 1006 0.298215521020485 340 759368
SGTC_3354 9151612 71.43 µM 0.529460766044778 0.300369559092727 no 1007 0.298242927107335 322 27261949
SGTC_2274 7947094 46.08 µM 0.528861046073256 0.300583557796357 no 1008 0.298450923067223 319 2971028
SGTC_1500 4488-1866 171 µM 0.52814902870732 0.300837717036041 no 1009 0.298697951876301 365 2900003
SGTC_2341 7987486 176.74 µM 0.527623419530666 0.301025398827311 no 1010 0.298880367449266 327 1258686
SGTC_3128 9127691 49.47 µM 0.527392707831511 0.301107796825716 no 1011 0.298960453201379 338 41316314
SGTC_1614 st002383 48.6 µM 0.526932083629157 0.301272337787342 no 1012 0.299120376432718 305 1947235
SGTC_725 1497-0963 19 µM 0.526165067344141 0.301546415803413 no 1013 0.299386761472773 328 3549977
SGTC_3070 9117005 49.47 µM 0.526139914607551 0.301555405533001 no 1014 0.29939549884904 331 8779016
SGTC_320 4092-0846 5.34 µM 0.525569926851101 0.301759154679687 no 1015 0.299593528077614 331 1359356
SGTC_2707 st078556 66.6 µM 0.524486954996847 0.30214644670607 no 1016 0.299969945335865 319 17250899
SGTC_2164 5685496 200 µM 0.524162897942912 0.302262379238999 no 1017 0.300082622045548 318 759046
SGTC_2008 4012253 172 µM 0.522113789472322 0.302995916553639 no 1018 0.300795552988515 325 603940
SGTC_1994 st072947 40.9 µM 0.52067144027544 0.303512724142144 no 1019 0.301297836500048 339 5286565 YDL195W SEC31
SGTC_268 camptothecin 39.6153 µM 0.52042469441617 0.303601174978969 no 1020 0.301383801068519 332 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_875 0709-0210 25.7 µM 0.519879216329225 0.303796753005281 no 1021 0.301573881073673 330 6251364
SGTC_1229 0139-0193 12.2 µM 0.519521380151493 0.303925083629975 no 1022 0.301698603732199 338 3090752
SGTC_338 4055-0136 114 µM 0.519369046952072 0.303979722150667 no 1023 0.301751706020649 323 2900563
SGTC_643 k048-0106 28.4 µM 0.516191331502726 0.305120494751263 no 1024 0.30286039201268 338 6763920
SGTC_2556 citropten 84.59 µM 0.515974386310459 0.305198445477044 no 1025 0.30293614936183 288 2775 A potential DNA crosslinker.
SGTC_2518 prenyletin 46.28 µM 0.51595305981047 0.305206108793472 no 1026 0.302943597042135 306 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_509 pifithrin 175 µM 0.514918191923752 0.305578073591712 no 1027 0.303305093970154 353 4817 A p53 inhibitor.
SGTC_589 1227-0070 34.1 µM 0.513993638649737 0.305910557582895 no 1028 0.303628219107417 333 2841384
SGTC_2370 9071495 200 µM 0.513264867023424 0.306172748186189 no 1029 0.303883028136478 349 21791103
SGTC_3272 9137413 49.47 µM 0.512067566982927 0.306603717103722 no 1030 0.30430186120342 338 17614870
SGTC_321 4534-3890 65.3 µM 0.508613644639143 0.307848456315219 no 1031 0.305511531485964 355 699746
SGTC_773 4358-1457 44.6 µM 0.506320914310755 0.308675944180614 no 1032 0.306315691646339 358 1186886
SGTC_945 3381-0768 11.3 µM 0.506087127370222 0.308760376822115 no 1033 0.306397743417182 349 1126236 YIL048W NEO1
SGTC_1426 4048-4480 71.7 µM 0.503986696071534 0.309519404965403 no 1034 0.307135362963447 329 14224343
SGTC_190 3970-0790 3.722 µM 0.50269789531601 0.309985538829137 no 1035 0.307588344832216 334 2832352
SGTC_1886 st057356 49.9 µM 0.501838476047323 0.310296543748242 no 1036 0.307890572823564 332 24207747
SGTC_2885 9057732 51.95 µM 0.501073968959718 0.310573316106352 no 1037 0.308159533066594 340 6471414
SGTC_2011 4012611 177 µM 0.498903795156009 0.31135956204497 no 1038 0.308923580150738 338 2049887
SGTC_2347 9049783 174.81 µM 0.49878566992156 0.311402383126986 no 1039 0.308965191951672 363 6467988 YPL169C MEX67
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 0.497445996305934 0.311888201030973 no 1040 0.309437288261878 337 688669
SGTC_2146 5545642 200 µM 0.497326327953067 0.311931613387466 no 1041 0.309479474293404 339 825326
SGTC_2224 6650123 117.647 µM 0.49592465248026 0.312440296735305 no 1042 0.309973786113437 347 2908370
SGTC_1151 3909-8316 15.3 µM 0.493653188238175 0.313265395000753 no 1043 0.310775565274503 354 800431
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.492519313924827 0.313677619680492 no 1044 0.311176135879903 348 23847180
SGTC_1934 st074720 32.6 µM 0.492411787658634 0.313716723387839 no 1045 0.311214133953418 331 17250992
SGTC_164 4100-3994 89.624 µM 0.490401280254223 0.31444826271827 no 1046 0.311924985460674 372 4615967
SGTC_1220 1838-0075 193 µM 0.489140547785971 0.314907362599969 no 1047 0.31237109824397 323 5529645
SGTC_1972 st070201 17.4 µM 0.487536418580411 0.315491925194062 no 1048 0.312939120434245 340 2829099
SGTC_2221 6807166 181.081 µM 0.487075611957546 0.315659933767006 no 1049 0.313102374286574 332 674925
SGTC_1691 st019933 84.6 µM 0.486301712058575 0.315942180835033 no 1050 0.31337663277679 375 6176082
SGTC_283 0987-0079 11.7 µM 0.485463624640044 0.316247958628281 no 1051 0.31367375479015 355 411556
SGTC_2055 5235184 200 µM 0.484153629773399 0.316726164500721 no 1052 0.314138421412457 379 2836034
SGTC_1837 st055472 66.5 µM 0.48383988276775 0.316840741502551 no 1053 0.314249753997183 321 676091
SGTC_173 1273-0061 2.693 µM 0.483488717846618 0.316969003958921 no 1054 0.314374384310156 351 2847414 YPL266W DIM1
SGTC_3247 9135149 49.47 µM 0.483449102005185 0.316983474966144 no 1055 0.314388445513201 368 8934436 YOR116C RPO31
SGTC_290 2043-6722 48.1 µM 0.483114262870343 0.317105797307315 no 1056 0.314507303702142 337 773758 YLR208W SEC13
SGTC_527 4476-4215 268 µM 0.482385028606627 0.317372267943318 no 1057 0.31476622725861 328 4418754
SGTC_380 3970-0968 6 µM 0.481557356066942 0.317674823781806 no 1058 0.315060212898564 341 2891601
SGTC_3051 9093778 49.47 µM 0.481367948805832 0.317744078771684 no 1059 0.315127506007639 372 17217378
SGTC_2796 7949634 45.45 µM 0.480888814916164 0.317919298052739 no 1060 0.315297761341994 346 2971588
SGTC_2172 5754775 163.918 µM 0.479545012133483 0.318410944220374 no 1061 0.315775477162596 338 2263357
SGTC_2078 5212016 200 µM 0.479329195686031 0.318489933067196 no 1062 0.315852227652004 364 1899708
SGTC_1778 st046819 58.9 µM 0.478628943256953 0.318746282346499 no 1063 0.316101312068121 375 671715
SGTC_1689 st020265 53.493 µM 0.478305545838806 0.318864701368506 no 1064 0.316216374857623 366 5758320 YPR016C TIF6
SGTC_2017 5132927 60.65 µM 0.478166125927173 0.318915758717628 no 1065 0.316265985086263 338 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_1137 ixabepilone 100 µM 0.4771555273897 0.319285955473799 no 1066 0.316625688394171 332 154225 A novel microtubule stabilizer.
SGTC_808 0711-0032 135 µM 0.476545877799764 0.319509366062249 no 1067 0.316842765476361 365 4252555
SGTC_647 0140-0236 81 µM 0.476505879414851 0.319524026056854 no 1068 0.316857009851282 348 990837
SGTC_3134 9127454 49.47 µM 0.476339635164749 0.319584960034461 no 1069 0.316916216286392 361 24262820
SGTC_2390 9097792 176.6 µM 0.472190193907439 0.321107441066098 no 1070 0.318395519232627 337 4497149
SGTC_936 3005-4620 401 µM 0.472059248856503 0.321155535571912 no 1071 0.318442249326552 379 777207
SGTC_2147 5545932 89.7195 µM 0.471383412700098 0.321403809558404 no 1072 0.318683479515749 370 797404
SGTC_861 0443-0273 110 µM 0.471066833721106 0.321520134914979 no 1073 0.318796504359902 351 6149169
SGTC_2640 pentamidine 10.38 µM 0.470043258789356 0.321896362128683 no 1074 0.319162055804557 339 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1130 3454-2858 15.9 µM 0.469814466043854 0.32198048262933 no 1075 0.319243789099812 387 715628 YIL048W NEO1
SGTC_2510 benzyl isothiocyanate 8.31 µM 0.469720979344658 0.322014857620706 no 1076 0.319277188561457 344 2346 DNA damaging agent; causes G2/M arrest.
SGTC_2911 7942208 15.64 µM 0.469326657552886 0.322159866212729 no 1077 0.319418081804215 321 1243384
SGTC_198 3454-2873 16.191 µM 0.469191066579529 0.322209734933315 no 1078 0.319466535195503 352 710957
SGTC_328 k915-0120 63.5 µM 0.468885671057563 0.322322067435218 no 1079 0.319575679477818 328 6624543
SGTC_2532 xanthone 78.9 µM 0.467991616508862 0.322651017464201 no 1080 0.319895292465081 347 7020 An insecticide.
SGTC_1403 3909-7815 62.9 µM 0.467948381668837 0.322666928406602 no 1081 0.319910751755728 347 6615483
SGTC_1018 4259-0013 28.1 µM 0.4662647278905 0.323286785580153 no 1082 0.320513011418939 348 6801262
SGTC_3090 9117696 49.47 µM 0.464369649440798 0.323985068486382 no 1083 0.321191465514652 360 7923821
SGTC_3133 9127736 49.47 µM 0.463980748059299 0.324128444395348 no 1084 0.321330769424437 354 27243420
SGTC_3237 9133362 49.47 µM 0.462976005983487 0.324498982440781 no 1085 0.321690782905216 378 43845137
SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.460012641606898 0.325592850447963 no 1086 0.32275357331356 385 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_1340 1486-1359 257 µM 0.458279121168302 0.326233443388175 no 1087 0.323375961164641 349 4309068
SGTC_798 1287-0182 476 µM 0.457998805308913 0.326337077570669 no 1088 0.323476649790845 378 1649755
SGTC_1715 st032160 10.2275 µM 0.456667633509267 0.32682940139459 no 1089 0.323954979114697 362 5289825
SGTC_1183 1254-0324 198 µM 0.4566248750065 0.326845220307817 no 1090 0.323970348332063 326 5799357
SGTC_3200 9114385 49.47 µM 0.455023960055349 0.327437717708037 no 1091 0.324546000740889 311 17018030 YLR208W SEC13
SGTC_2520 obtusaquinone 4.71 µM 0.454065680331515 0.327792584499604 no 1092 0.324890776993096 385 5967872
SGTC_3291 9121177 71.43 µM 0.453834913975625 0.327878064343067 no 1093 0.324973826074994 328 17015612
SGTC_2524 avocatin b 10.57 µM 0.453575792152906 0.327974058289776 no 1094 0.325067090197979 344 6710748
SGTC_2708 st078559 56 µM 0.453232458530227 0.328101266740068 no 1095 0.325190681039897 344 17250902
SGTC_1136 pergolide 1.05886 µM 0.452174832353559 0.32849325280596 no 1096 0.32557151876051 359 47811 A dopamine receptor agonist.
SGTC_514 4466-0038 2.65 nM 0.451244885829673 0.328838073236819 no 1097 0.325906531186287 323 5722064
SGTC_2819 7996655 46.38 µM 0.449541620290049 0.329470015026953 no 1098 0.326520495571767 370 6456960
SGTC_964 1287-0107 19.4 µM 0.449359886647601 0.329537470242749 no 1099 0.326586031635855 361 51516812 YPR165W RHO1
SGTC_2951 9072950 58.06 µM 0.448001335460051 0.330041907800321 no 1100 0.327076116401682 358 16488155
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.447255259973816 0.330319061321183 no 1101 0.327345383195011 337 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_948 3448-0295 75.3 µM 0.446400277767573 0.330636786204473 no 1102 0.327654066106068 344 678569
SGTC_252 miconazole 1.30953 nM 0.446181828012557 0.330717985171428 no 1103 0.32773295414726 346 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_530 4358-1714 28 µM 0.44475910386946 0.331247014264065 no 1104 0.328246925821065 364 1564641
SGTC_2010 4012422 159 µM 0.444628130752042 0.331295732570631 no 1105 0.328294257383324 375 952393
SGTC_3334 9142812 21.919 µM 0.443648466759147 0.331660230459879 no 1106 0.328648379447928 363 45283678
SGTC_512 prima-1 270 µM 0.443578759754587 0.331686172020207 no 1107 0.328673582516511 343 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_1475 4092-1048 11.7 µM 0.443436555660575 0.331739095977829 no 1108 0.328724999845339 367 2881759
SGTC_681 1642-0006 26.6 µM 0.442906282801937 0.331936476709651 no 1109 0.328916761401579 378 4446530
SGTC_1793 st048256 72.231 µM 0.442496918087952 0.332088884337843 no 1110 0.329064829987913 369 672022
SGTC_1035 k081-0041 55.2 µM 0.440640173949794 0.332780503819699 no 1111 0.329736757005767 386 731709
SGTC_184 1494-0393 24.714 µM 0.438282792448844 0.333659426201065 no 1112 0.33059064909867 355 3090647
SGTC_2737 bleomycin 30.5 nM 0.436253387164833 0.334416798560369 no 1113 0.331326448627554 361 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_2142 5622915 118.518 µM 0.433940506509399 0.335280786010132 no 1114 0.332165822037648 347 5322196
SGTC_1109 tnp00067 928.257 nM 0.433670041775913 0.335381876419812 no 1115 0.332264032197506 347 676295
SGTC_1949 st076024 69.1 µM 0.432874930416704 0.335679130691845 no 1116 0.332552816803171 350 2921930
SGTC_1080 nisoldipine 24.4 µM 0.432712753560886 0.335739773529855 no 1117 0.332611731680996 383 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_582 0987-0078 156 µM 0.431395133281318 0.336232630102427 no 1118 0.33309054398598 368 1625765
SGTC_1361 1608-0041 5.61 µM 0.429451595450308 0.336960125354944 no 1119 0.333797306298521 352 X1361
SGTC_269 exalamide 29 µM 0.429289336160033 0.33702088907184 no 1120 0.333856338175182 353 3316 A derivative of salicylamide.
SGTC_2131 toluylene red 5.2905 µM 0.428043397718363 0.33748761629801 no 1121 0.334309762451875 321 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_2474 5321570 43.32 µM 0.425575802185629 0.338412712662677 no 1122 0.335208487844372 400 2841384
SGTC_1168 k815-0004 80.5 µM 0.424166976132776 0.338941316701762 no 1123 0.335722021516155 376 642433
SGTC_2601 securinine 100 µM 0.42368946747489 0.339120554236499 no 1124 0.335896148736217 365 442872 A GABA receptor antagonist.
SGTC_1123 mangostin 811.285 nM 0.42297890667106 0.339387337574427 no 1125 0.336155325432822 349 5281650 An antioxidant.
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.420162263476061 0.340445650372325 no 1126 0.337183460077132 384 6710655
SGTC_2650 prasterone 100 µM 0.41807911584318 0.341229172488236 no 1127 0.33794463679995 354 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_204 PMA1.184 62.41 µM 0.416583023031843 0.341792311990263 no 1128 0.338491714574038 359 2252213 YGL008C PMA1
SGTC_2963 9082507 9 µM 0.416552452946868 0.341803822454323 no 1129 0.338502896727228 366 16459611
SGTC_2630 antimycin a 100 µM 0.414860024364442 0.342441296790982 no 1130 0.339122187765463 366 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_2914 7968218 45.32 µM 0.414661715111258 0.342516021874423 no 1131 0.339194781300798 372 2977111
SGTC_2505 galangin 7.89 µM 0.413693025573218 0.34288112317839 no 1132 0.33954946774866 396 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_3300 9124615 50.48 µM 0.412687821065207 0.343260142242527 no 1133 0.339917674483274 362 24824903
SGTC_20 0481-0013 4.944 µM 0.412169452324548 0.343455658293912 no 1134 0.340107612845632 370 182045
SGTC_2684 capsaicin 100 µM 0.412163677314745 0.343457836722885 no 1135 0.340109729127646 387 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_23 0213-0011 39.996 µM 0.411011360293354 0.343892613665562 no 1136 0.340532102323503 359 627608
SGTC_1621 st003705 32.4 µM 0.410977640042471 0.34390533965513 no 1137 0.340544465245115 369 24207032
SGTC_2842 9000675 19.48 µM 0.409443151883947 0.344484640905876 no 1138 0.341107238756248 357 2989072
SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.409384256241975 0.34450688251899 no 1139 0.341128845787308 362 6708630 An antioxidant.
SGTC_2351 9026858 72.31 µM 0.406287767354981 0.345677009943738 no 1140 0.342265586200283 385 1409300
SGTC_1631 benzylvanillin 81.9 µM 0.405112546506456 0.346121499332935 no 1141 0.342697392226992 348 75506
SGTC_649 1123-0311 367 µM 0.404796144904247 0.34624120429633 no 1142 0.342813681375834 376 693629 YIL048W NEO1
SGTC_1785 bathophenanthroline 24 µM 0.403999926680749 0.346542507361899 no 1143 0.343106386546051 359 72812 An iron chelator.
SGTC_2475 5812728 15.03 µM 0.403997140085573 0.346543562029464 no 1144 0.343107411117619 362 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_394 menadione 8.33 µM 0.403648927042144 0.346675362689384 no 1145 0.343235450696684 388 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_2701 st077767 14.721 µM 0.40302333360509 0.346912200056861 no 1146 0.343465529560122 369 5721188
SGTC_1514 1189-1591 158 µM 0.402671465153581 0.347045436822924 no 1147 0.343594964173461 399 767698 YMR146C TIF34
SGTC_3027 9089541 49.47 µM 0.401613543601928 0.34744613800666 no 1148 0.343984230437432 370 9943819
SGTC_1341 1486-1360 280 µM 0.401494537434142 0.347491223778863 no 1149 0.344028029567883 365 3976547
SGTC_3352 9151559 45.5865 µM 0.401264498724628 0.347578380611693 no 1150 0.344112699140768 340 17159339
SGTC_1453 4237-0541 195 µM 0.398920547262496 0.348466913191555 no 1151 0.344975874358909 350 739892
SGTC_1688 st021091 57.6 µM 0.396955932908054 0.3492122899767 no 1152 0.345699978452509 392 3656366
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 0.396414960661256 0.349417637743769 no 1153 0.345899465590372 376 1377
SGTC_1656 st012921 11 µM 0.393647467856936 0.350468839345768 no 1154 0.346920665331494 383 6732821
SGTC_1002 4049-0206 172 µM 0.392601239714391 0.350866536578394 no 1155 0.347307011887368 372 4662749
SGTC_2130 NSC 7 2.4545 µM 0.390843085191932 0.351535222603629 no 1156 0.347956612805743 363 21448
SGTC_2759 disulfiram 3.38 µM 0.390820092447856 0.351543970576598 no 1157 0.347965111100211 355 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1170 0310-0127 64.8 µM 0.39037722824527 0.351712480985408 no 1158 0.348128812000788 411 774975
SGTC_383 2324-0395 7.37 µM 0.390133744323387 0.351805139352501 no 1159 0.34821882577483 379 3146421
SGTC_576 1073-0113 22.7 µM 0.389363173761796 0.352098439744542 no 1160 0.348503754979482 399 5439563
SGTC_1048 3161-0300 24.5 µM 0.386251020346352 0.353283905024704 no 1161 0.349655385583694 372 2165101
SGTC_1706 st031321 9.9705 µM 0.38549577712143 0.353571803644163 no 1162 0.349935067279611 369 6103185
SGTC_1534 6-azauridine 81.6 µM 0.384541351558087 0.35393575037461 no 1163 0.350288626657339 370 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_1302 1159-0335 255 µM 0.384011055829444 0.354138023334932 no 1164 0.350485126609127 382 649284
SGTC_1564 D-Arginine 115 µM 0.383271413397719 0.354420217038177 no 1165 0.350759266360524 378 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_854 0422-0053 192 µM 0.382731536762335 0.354626245136446 no 1166 0.35095941435233 381 3596728
SGTC_3268 9137683 49.47 µM 0.382073781428253 0.354877315663164 no 1167 0.351203319298383 426 1953228
SGTC_2 0422-0095 29 µM 0.381508977262302 0.355092956289732 no 1168 0.351412805566011 349 6790840
SGTC_3318 9139014 38.6185 µM 0.381207474215635 0.355208088304973 no 1169 0.351524651746242 389 16643984
SGTC_413 propylparaben 100 µM 0.379839922306543 0.355730467772243 no 1170 0.352032122839592 365 7175 A pharmaceutical preservative.
SGTC_1066 ketoconazole 628 nM 0.378425289542808 0.356271116467536 no 1171 0.35255734213159 401 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_842 0271-0008 11.1 µM 0.378370542379088 0.356292045723135 no 1172 0.352577674101882 368 1221709
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.377616121063992 0.356580496988475 no 1173 0.352857893525583 386 1241132 A phosphatase inhibitor.
SGTC_2714 st079313 56.9 µM 0.375889293239122 0.35724105427533 no 1174 0.353499600283587 372 2939799
SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.375603720111872 0.35735033484584 no 1175 0.353605762352558 349 3256 An antibiotic and ribosome inhibitor.
SGTC_937 3122-0005 46.7 µM 0.375602048753559 0.357350974460739 no 1176 0.353606383715053 383 759535
SGTC_645 0845-0943 5.41 µM 0.37503496893527 0.357568014306995 no 1177 0.35381723003583 381 1885106
SGTC_1617 st002906 78 µM 0.374787710061249 0.357662662728259 no 1178 0.353909177564068 404 5150859
SGTC_127 0180-0333 59.125 µM 0.374301332060981 0.357848869290762 no 1179 0.354090070575441 352 771601
SGTC_2899 9053889 58.44 µM 0.373364854379194 0.358207488749288 no 1180 0.354438456740639 405 6470052
SGTC_2121 5257820 149.641 µM 0.372050125551146 0.358711168687149 no 1181 0.354927764510236 375 791256
SGTC_1697 st025554 27.742 µM 0.371655261025238 0.358862491527919 no 1182 0.35507476956644 369 1269519
SGTC_840 0245-0196 390 µM 0.369763290903912 0.359587853006757 no 1183 0.355779434636415 376 3827528
SGTC_3106 9121286 49.47 µM 0.366628133504254 0.360790952757038 no 1184 0.356948209940074 347 15943471
SGTC_3262 9137218 49.47 µM 0.366233702661501 0.36094241136553 no 1185 0.357095347726987 364 17650664
SGTC_2673 kobusone 100 µM 0.366105825773798 0.360991519853696 no 1186 0.357143055259719 404 6710676 An epoxy ketone and protein crosslinker.
SGTC_2764 methyldopa 94.69 µM 0.366049697760364 0.361013075386336 no 1187 0.357163995863501 401 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_50 0929-0078 56.389 µM 0.365530346188179 0.361212549300827 no 1188 0.357357779322292 390 1377751
SGTC_1680 diphenhydramine 100 µM 0.365146642706601 0.361359947387196 no 1189 0.357500972616408 402 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_1999 st074831 12.5 µM 0.364227609098097 0.361713073949886 no 1190 0.357844025899298 403 17112523
SGTC_743 1275-0778 158 µM 0.364221627897818 0.361715372533461 no 1191 0.357846258914864 406 2849257 YMR203W TOM40
SGTC_221 trifluoperazine 10.304 µM 0.364035329567958 0.361786969738043 no 1192 0.357915813789477 406 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_265 mycophenolic acid 32.932 µM 0.363579559391795 0.36196214935285 no 1193 0.358085996429561 387 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_3053 9095903 49.47 µM 0.363552573962211 0.361972522367439 no 1194 0.358096073558551 429 17174018
SGTC_1330 1469-0054 61.8 µM 0.361648735199307 0.362704600470498 no 1195 0.358807270402603 409 7102664
SGTC_3342 9147791 14.508 µM 0.361379195642354 0.362808286447376 no 1196 0.358907999070884 393 1838168
SGTC_1825 st052143 62.6 µM 0.360416822986998 0.363178572205214 no 1197 0.35926772394401 394 674173
SGTC_1560 lithocholic acid 53.1 µM 0.359959721285672 0.363354493030963 no 1198 0.359438627529656 402 9903 A bile acid which acts as a detergent.
SGTC_1446 4239-0190 62 µM 0.35976104214611 0.363430965962997 no 1199 0.359512919500186 397 1340085
SGTC_550 4123-0385 25.7 µM 0.359342894437339 0.363591931596931 no 1200 0.359669294566346 380 5731123
SGTC_2588 indole-3-carbinol 100 µM 0.359191027357253 0.363650398674008 no 1201 0.359726094250016 420 3712 Induces cell cycle arrest.
SGTC_1498 4478-3555 97.6 µM 0.358221346645123 0.364023789399272 no 1202 0.36008883675247 395 3437919
SGTC_2612 dictamnine 15.46 µM 0.356938109502353 0.364518118406932 no 1203 0.360569069538919 398 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_1400 3771-8998 51.5 µM 0.356255058388717 0.364781335537864 no 1204 0.360824781224525 408 670767
SGTC_775 4577-0580 57.3 µM 0.355621273001424 0.36502562489878 no 1205 0.361062105119731 397 2006902
SGTC_1709 st033179 39.1045 µM 0.355166062331618 0.36520111735809 no 1206 0.361232593893592 390 573381
SGTC_2991 9074669 71.4286 µM 0.354933689596321 0.365290712399113 no 1207 0.361319634431032 415 17333109
SGTC_2375 9072683 200 µM 0.354706945415586 0.365378144348227 no 1208 0.361404573584698 414 16798029
SGTC_2581 avocatin a 64 µM 0.353562897950638 0.365819392611641 no 1209 0.361833241834438 400 6710728 A skin care supplement.
SGTC_979 1426-2828 121 µM 0.353255474372192 0.365937993265002 no 1210 0.36194846133019 394 747872
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.352978337591234 0.366044920584708 no 1211 0.362052340341355 425 688667
SGTC_1375 2910-0797 186 µM 0.35272898530257 0.366141136742734 no 1212 0.362145813593476 418 742508
SGTC_1204 4049-0315 18.3 µM 0.349828597262605 0.367260910007024 no 1213 0.363233667975973 374 588402
SGTC_2309 7664088 163.95 µM 0.348263522083158 0.367865619606206 no 1214 0.363821143122352 423 704922
SGTC_679 0422-0091 41.4 µM 0.347957475766716 0.367983907316966 no 1215 0.363936059815111 411 627384 YHR062C RPP1
SGTC_1176 0848-0131 83.3 µM 0.347679446096393 0.368091377373084 no 1216 0.36404046720516 410 6769040
SGTC_3256 9138902 49.47 µM 0.345672877756013 0.368867305338659 no 1217 0.3647942847737 408 17228773
SGTC_132 0417-1715 25.805 µM 0.344587808318038 0.369287118196463 no 1218 0.365202136302754 417 6769098
SGTC_1115 galangin 695.678 nM 0.344250581381492 0.36941762292548 no 1219 0.365328922892545 428 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2551 apiole 73.87 µM 0.343897444673588 0.369554300766978 no 1220 0.365461706827164 401 10659 A possible DNA adduct former.
SGTC_825 1988-2224 89.6 µM 0.342329543417391 0.37016133929546 no 1221 0.366051452373272 384 1180859
SGTC_280 3448-3607 3.04 µM 0.342231928955663 0.370199143040012 no 1222 0.366088179259116 399 626179
SGTC_2619 obliquin 87.91 µM 0.34050141555121 0.37086953730478 no 1223 0.366739478475985 419 6708593 A bioactive alkalod. YER133W GLC7
SGTC_3120 9124077 49.47 µM 0.339550228055661 0.371238190852651 no 1224 0.367097632759472 424 18774327 YGL155W CDC43
SGTC_3019 9081971 49.47 µM 0.339235609594641 0.371360154153346 no 1225 0.36721612273429 399 16451803
SGTC_2971 9092186 9.93 µM 0.338927961306684 0.371479427926356 no 1226 0.36733199986862 337 25236400
SGTC_2824 7998404 51.95 µM 0.337165725586459 0.3721628757982 no 1227 0.367995986552897 402 837851
SGTC_617 3770-0098 35 µM 0.336387219601191 0.372464932213586 no 1228 0.368289442909271 394 5962639
SGTC_2992 9074591 71.4286 µM 0.335752898251257 0.372711103735951 no 1229 0.368528605973594 380 17741321
SGTC_421 streptovitacin 30 mM 0.335058391833848 0.372980691899401 no 1230 0.368790519494941 387 91467 include heat shock
SGTC_2278 7948257 134.34 µM 0.334890847620829 0.373045737243617 no 1231 0.368853713203152 402 1247028
SGTC_2258 7960471 200 µM 0.332657362974668 0.373913183388331 no 1232 0.369696468780262 419 2974708
SGTC_91 0417-1751 58.384 µM 0.332239906594099 0.374075387108978 no 1233 0.36985405621952 404 6795624
SGTC_876 0720-0963 56.8 µM 0.332114761012434 0.374124017083147 no 1234 0.369901302233426 417 765861
SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.331754943689615 0.374263848654922 no 1235 0.370037154436804 394 229346 A bile salt which induces apoptosis.
SGTC_326 k292-0812 17.5 µM 0.330761946461944 0.3746498312518 no 1236 0.370412153385943 419 3579357
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.328087977574272 0.375689838915736 no 1237 0.371422571926787 373 6708739 YPR165W RHO1
SGTC_1419 3993-2473 62.6 µM 0.326957086132212 0.376129957788777 no 1238 0.371850171594591 397 704026
SGTC_2700 st077718 96.8 µM 0.326916735463629 0.376145664390747 no 1239 0.371865431450129 383 904970
SGTC_351 caspofungin 25 nM 0.326151659595861 0.376443510940876 no 1240 0.372154806661821 392 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_1445 4239-0156 97.7 µM 0.326003657404291 0.376501137179936 no 1241 0.372210793981336 434 4008346
SGTC_771 0250-0039 27.3 µM 0.325861048724345 0.376556666001341 no 1242 0.372264743560542 429 3005115
SGTC_3040 9091894 49.47 µM 0.32568511827881 0.376625173137029 no 1243 0.372331302385053 392 25236966
SGTC_1820 st053765 18.6 µM 0.325129052004174 0.376841730316535 no 1244 0.372541701033241 395 3690829
SGTC_3045 9092950 49.47 µM 0.324745446552237 0.376991146099955 no 1245 0.372686867903311 400 44120432
SGTC_2382 9035899 200 µM 0.32444418843805 0.377108500198019 no 1246 0.372800884951774 437 6462679
SGTC_2822 7994718 71.43 µM 0.323011868661535 0.377666610730265 no 1247 0.373343126792353 431 1018011
SGTC_1232 0279-0259 161 µM 0.32246628768123 0.377879266337393 no 1248 0.373549736686352 412 1560000
SGTC_1269 0831-0796 3.05 µM 0.322124439036289 0.378012530374372 no 1249 0.373679212279343 408 927758
SGTC_1305 1181-0477 144 µM 0.322104243673344 0.378020403656688 no 1250 0.373686861743979 383 6252086
SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.321496139618427 0.378257500353947 no 1251 0.373917218629291 419 140250 A respiratory chain inhibitor.
SGTC_815 1582-0027 36.9 µM 0.320086737972807 0.378807195073965 no 1252 0.374451289393507 409 3128206
SGTC_1998 st075797 76.8 µM 0.319896630805804 0.378881359451402 no 1253 0.374523346004684 427 24208315
SGTC_1521 st012942 49.4 µM 0.317590083505018 0.379781541435469 no 1254 0.375397948606788 401 24207259
SGTC_3314 9135860 59.4275 µM 0.316494801066551 0.380209228622827 no 1255 0.37581348533699 410 25252478
SGTC_1291 0993-0025 5.79 µM 0.315976796152717 0.38041155085933 no 1256 0.376010060259751 412 4353356
SGTC_1956 st077085 54 µM 0.315835953483443 0.380466566815525 no 1257 0.376063513459171 439 24208685
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.315585862381911 0.380564263346418 no 1258 0.376158434940105 434 6728940
SGTC_2897 9048598 12.99 µM 0.315370445276018 0.380648420803783 no 1259 0.376240201994821 392 6467404
SGTC_2284 7945075 39.21 µM 0.314875935862913 0.380841633203008 no 1260 0.376427926657948 436 1245402
SGTC_2848 9016370 25.97 µM 0.312368526749101 0.381821772769455 no 1261 0.377380233267748 410 7894410
SGTC_3031 9088762 49.47 µM 0.312287671129113 0.381853391666834 no 1262 0.377410954442272 400 205253
SGTC_2607 solasodine 47.35 µM 0.310050358075216 0.382728613384296 no 1263 0.378261330860072 393 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_2543 pimpinellin 60.67 µM 0.309994530310856 0.382750460508731 no 1264 0.378282557899709 420 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_3355 9151058 44.0485 µM 0.309310272066715 0.383018262133502 no 1265 0.378542758933896 390 17015728
SGTC_1167 k781-0610 148 µM 0.307544621804893 0.383709551696328 no 1266 0.379214432142859 394 4525169
SGTC_3179 9107801 49.47 µM 0.3044849475665 0.384908354774608 no 1267 0.380379229397229 361 4818259
SGTC_1496 4469-0713 57.4 µM 0.302531587489575 0.385674272372073 no 1268 0.381123428770154 435 746691
SGTC_1101 ebselen 5.29 µM 0.30235477236098 0.385743624102783 no 1269 0.381190814295851 429 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_2585 alliin 100 µM 0.302244761411754 0.385786775250054 no 1270 0.381232742083259 437 87310 A garlic compound which reacts with lipids.
SGTC_776 4476-4378 112 µM 0.301956357014492 0.385899906885591 no 1271 0.381342666470651 414 2892008
SGTC_3 0833-0587 95.581 µM 0.299434137283709 0.386889703961374 no 1272 0.382304409263874 395 5382644
SGTC_1757 st041620 31.8375 µM 0.299072324114151 0.387031751165562 no 1273 0.382442431276772 401 5289815
SGTC_1955 wogonin 32.4 µM 0.297202098483231 0.387766239262405 no 1274 0.383156109930659 375 5281703 A flavanone.
SGTC_662 k832-1615 104 µM 0.290857484937805 0.390260919201288 no 1275 0.385580159137139 446 5878478
SGTC_1661 st013063 9.66 µM 0.290412967206681 0.390435872853825 no 1276 0.385750162290515 415 721395
SGTC_1772 st048439 82.2 µM 0.290195958033261 0.390521291564197 no 1277 0.385833164128417 398 2927068 YDL195W SEC31
SGTC_2886 9058944 51.95 µM 0.289319142290516 0.390866475765666 no 1278 0.386168582488693 408 4949929
SGTC_1463 k081-0032 34.1 µM 0.288394094627945 0.391230741106219 no 1279 0.386522543802591 410 977755
SGTC_1960 st011366 51.8 µM 0.288374941674464 0.391238284167152 no 1280 0.386529873509897 427 3972846
SGTC_3209 9113616 49.47 µM 0.2867545972922 0.391876576749454 no 1281 0.387150114815807 439 16649353
SGTC_22 0964-0034 14.468 µM 0.286572041555953 0.391948508119187 no 1282 0.387220012258732 438 138402
SGTC_1332 1480-0653 17.5 µM 0.28546367333791 0.392385311168482 no 1283 0.387644465755397 433 5749438
SGTC_1567 st069303 68.4 µM 0.283244186307331 0.393260408443406 no 1284 0.388494829404351 437 5581319
SGTC_1851 st056236 18.9 µM 0.281658438435626 0.393885966383797 no 1285 0.389102713004688 418 5393171
SGTC_95 0471-0001 561.058 µM 0.281028644431537 0.394134488422004 no 1286 0.389344214857631 372 4015405
SGTC_2067 5224629 34.075 µM 0.280830782191761 0.394212575438905 no 1287 0.389420096268872 403 2835000
SGTC_1705 st027868 56.3335 µM 0.28007834193036 0.394509567396461 no 1288 0.389708700316417 450 292948
SGTC_155 k072-0202 43.6 µM 0.2795531953646 0.394716881737543 no 1289 0.38991016022979 441 5857737
SGTC_2879 9041815 71.43 µM 0.278499337789373 0.39513300747526 no 1290 0.390314536654102 412 4942971
SGTC_3094 9117742 49.47 µM 0.278216280496183 0.395244795753445 no 1291 0.390423169005196 448 17149698
SGTC_236 1509-0011 5.31 µM 0.277756809380517 0.395426273782562 no 1292 0.390599524052736 438 3107280
SGTC_205 1486-1330 71.903 µM 0.277183698696867 0.395652667994068 no 1293 0.390819527990797 415 4118834
SGTC_891 0929-0073 133 µM 0.275973864478302 0.396130700753113 no 1294 0.391284070058175 454 5603632
SGTC_2479 5617353 43.85 µM 0.274483491440561 0.396719795428432 no 1295 0.391856544274356 443 2731746
SGTC_596 1155-0152 116 µM 0.273660828747603 0.397045067599159 no 1296 0.392172641528436 423 280313
SGTC_2877 9040724 71.43 µM 0.273652327384038 0.397048429323167 no 1297 0.392175908436775 410 6463895
SGTC_2016 5121758 140 µM 0.272457606835646 0.397520937824364 no 1298 0.392635091743101 439 2795203
SGTC_3251 9135047 49.47 µM 0.272008160232926 0.397698731619653 no 1299 0.392807872439902 427 17682963
SGTC_3283 9109332 35.8195 µM 0.269945656162704 0.398514896806423 no 1300 0.393601031000391 413 17027281
SGTC_1351 1496-0003 46.5 µM 0.269168559702534 0.398822521430047 no 1301 0.393899986703796 434 3891978
SGTC_2839 9003951 25.97 µM 0.268035051977776 0.399271349168755 no 1302 0.394336168987104 444 2990634
SGTC_1508 1080-0625 72.9 µM 0.267551516245199 0.399462852251232 no 1303 0.394522277527195 421 767111
SGTC_3015 9080845 49.47 µM 0.26754638842006 0.399464883242898 no 1304 0.394524251309918 428 5296973
SGTC_664 1222-0054 14.9 µM 0.266880322245008 0.399728716996117 no 1305 0.394780653941491 413 6813991
SGTC_559 1550-0661 158 µM 0.265972029235822 0.400088572367329 no 1306 0.395130375400133 437 5830875
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 0.264840026266015 0.400537177829503 no 1307 0.395566350494909 411 16725076
SGTC_1674 st016616 23.6 µM 0.264708474040678 0.400589319649027 no 1308 0.395617024481198 396 625830
SGTC_363 0455-0021 3.06 µM 0.264684063174814 0.400598995293789 no 1309 0.395626427753679 432 4597466
SGTC_3060 1327-0027 12.5 µM 0.262799003728149 0.401346353119302 no 1310 0.396352751732335 425 16000455 YPR107C YTH1
SGTC_2979 9012552 45.46 µM 0.262405463082514 0.401502423386226 no 1311 0.396504430641897 441 17100905
SGTC_620 0109-0052 432 µM 0.261174618277721 0.401990652883477 no 1312 0.396978925338448 440 493037
SGTC_1875 nocodazole 6 µM 0.260119170290579 0.402409430974095 no 1313 0.397385925511212 429 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_460 trequinsin 123 µM 0.260115491885683 0.402410890678831 no 1314 0.397387344167518 435 5537 A vasodilator.
SGTC_453 enantio-paf c16 10 µM 0.259007521868024 0.40285062926509 no 1315 0.397814718436824 452 13871343 A lipid and platelet activating factor
SGTC_1360 1598-0022 39.8 µM 0.258121938749943 0.403202193859547 no 1316 0.398156400236939 442 761525
SGTC_259 usnic acid 108.925 µM 0.257546541917948 0.403430660626561 no 1317 0.398378445700458 452 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_185 k048-0037 25.491 µM 0.25748120453402 0.403456605539622 no 1318 0.398403661458967 433 6827589
SGTC_2398 5228213 48.84 µM 0.257342082539284 0.403511851102333 no 1319 0.398457354440599 441 80771 YMR134W ERG29
SGTC_183 3914-0051 30.55 µM 0.256777660112163 0.403736003875277 no 1320 0.398675208311505 434 1596232
SGTC_2936 9038235 15.59 µM 0.256711480157267 0.40376228842647 no 1321 0.398700754297501 437 4749415
SGTC_524 r073-0010 27.8 µM 0.255829008709779 0.404112819215789 no 1322 0.399041436692925 438 2772106
SGTC_1630 st005209 31.3 µM 0.254897256600762 0.404483008588853 no 1323 0.399401227607573 446 3367314
SGTC_1738 st035555 74 µM 0.254156340711789 0.404777438921427 no 1324 0.399687389185329 446 5331140
SGTC_2920 7982904 15.77 µM 0.253064129466515 0.405211567743147 no 1325 0.400109328681716 423 6456808
SGTC_909 3448-9333 149 µM 0.252942444013717 0.405259942141113 no 1326 0.40015634504021 425 3344074
SGTC_3206 9114350 49.47 µM 0.252247798609015 0.405536116674152 no 1327 0.40042476715769 448 17087243
SGTC_1503 4585-0012 61.3 µM 0.251281999864198 0.405920173471125 no 1328 0.400798045408386 426 2922052
SGTC_711 k292-0785 179 µM 0.251236032354055 0.405938455041818 no 1329 0.400815813971272 448 4146315
SGTC_483 fpl-64176 144 µM 0.250674823867231 0.406161667748601 no 1330 0.401032763472191 449 3423
SGTC_2903 5923464 63.88 µM 0.248682277177045 0.406954420840488 no 1331 0.401803279507219 436 2876576
SGTC_2423 st077119 87.2 µM 0.247617451033381 0.407378228324296 no 1332 0.402215203588801 400 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_1352 1496-0991 99 µM 0.245302628207743 0.408299915812085 no 1333 0.403111058447608 470 3000039
SGTC_2792 7535235 81.82 µM 0.244944008882109 0.408442751948504 no 1334 0.403249892616691 403 1281891
SGTC_769 0302-0231 76 µM 0.243118194873095 0.409170152022012 no 1335 0.403956918267003 448 571869 YER009W NTF2
SGTC_2763 lisinopril 49.32 µM 0.240964687075386 0.410028506530874 no 1336 0.404791242904942 462 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_2772 vinpocetine 57.06 µM 0.24095195872543 0.41003358113811 no 1337 0.40479617548799 462 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_51 1013-0126 23.419 µM 0.2397259270618 0.410522452557897 no 1338 0.405271367019497 460 1627850
SGTC_1260 0700-1617 7.75 µM 0.23925426090822 0.410710563167334 no 1339 0.405454215007152 436 2853078
SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.238996665137925 0.410813306577014 no 1340 0.405554084328521 452 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_1879 gemcitabine 100 µM 0.238204976620119 0.411129113926284 no 1341 0.405861058709696 436 60750 A nucleoside analog which inhibits DNA replication.
SGTC_2491 paeonol 100 µM 0.237747765127324 0.411311523460438 no 1342 0.40603836720929 439 11092 Increases levels of cortical cytochrome oxidase.
SGTC_2736 butenafine 14.65 µM 0.237377072506278 0.411459429419809 no 1343 0.406182137484471 434 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_3130 9127414 49.47 µM 0.236224926042112 0.41191921487409 no 1344 0.406629069293365 434 1494646
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.236046176041345 0.411990559237044 no 1345 0.406698419536466 440 279621
SGTC_1456 k015-0012 13 µM 0.234914200039968 0.412442431477556 no 1346 0.407137663952825 443 2989616
SGTC_942 3253-1115 227 µM 0.2339542360882 0.412825729408493 no 1347 0.407510253521869 443 46497897
SGTC_2314 7727897 200 µM 0.233327685862775 0.413075945541459 no 1348 0.407753480808328 416 900724
SGTC_208 k072-0098 12.366 µM 0.232864441263518 0.413260967425997 no 1349 0.407933335593749 433 5948901
SGTC_352 k048-0007 5.11 µM 0.232819166289419 0.413279051479408 no 1350 0.407950914650666 461 6811911
SGTC_1094 duloxetine 25.4 µM 0.232408947742425 0.413442912281538 no 1351 0.408110199940408 438 60834 A selective serotonin reuptake inhibitor.
SGTC_716 1683-5115 658 µM 0.231565272002128 0.413779963865883 no 1352 0.408437841647851 460 723597
SGTC_1662 st014054 52 µM 0.231308673692462 0.413882488452239 no 1353 0.40853750437856 443 2838777
SGTC_650 1328-0195 38 µM 0.229281577281298 0.414692626414945 no 1354 0.409325035658955 454 2780821
SGTC_161 4065-0411 162.148 µM 0.229167367953149 0.414738281506885 no 1355 0.409369417149962 443 1906281 YLR208W SEC13
SGTC_1233 0325-0408 14.2 µM 0.228429515769692 0.415033265084601 no 1356 0.409656172838252 455 12874
SGTC_3011 9081274 71.4286 µM 0.227574308464401 0.415375225627855 no 1357 0.409988597383852 423 6625322
SGTC_1071 trifluoperazine 6.31 µM 0.227153953159397 0.415543331113546 no 1358 0.41015201590978 459 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_567 1080-0542 68.4 µM 0.227143844250903 0.415547373986368 no 1359 0.410155946070104 448 5950415
SGTC_1294 1000-1494 117 µM 0.226323051054221 0.415875664988693 no 1360 0.410475085661535 433 712797 YDL207W GLE1
SGTC_976 1348-1067 47.6 µM 0.225849836007035 0.41606496255681 no 1361 0.410659107391515 419 5310671 YGL099W LSG1
SGTC_3097 9117246 49.47 µM 0.225639729934745 0.416149016358801 no 1362 0.410740818799184 435 16423892
SGTC_335 4077-0256 27.6 µM 0.224797857484918 0.416485849343642 no 1363 0.41106826645222 462 3121989
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.224641309919475 0.416548490761057 no 1364 0.411129162721711 475 7104
SGTC_2393 9031399 185.94 µM 0.224249220161761 0.416705392043335 no 1365 0.411281693196315 431 1526623 YDL150W RPC53
SGTC_2045 5106652 78.05 µM 0.223583576995119 0.416971790678046 no 1366 0.411540671920835 468 673349
SGTC_2812 7970281 58.44 µM 0.222971132343118 0.417216932290734 no 1367 0.411778986994631 441 2233435
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.221538579635052 0.417790461927825 no 1368 0.412336550282303 462 4620898
SGTC_442 cape 100 µM 0.221042316102175 0.417989184364636 no 1369 0.412529742149915 458 5281787
SGTC_1734 st037168 69.4 µM 0.220046359594926 0.418388065649283 no 1370 0.41291752484333 407 708907
SGTC_1794 st048918 76.9 µM 0.219983646378343 0.418413185150307 no 1371 0.412941945524984 454 672303
SGTC_3322 9139058 2.11 µM 0.219291971493821 0.418690254510827 no 1372 0.413211307764608 416 4908926 YPR165W RHO1
SGTC_3111 9122088 49.47 µM 0.218758358915563 0.418904035249382 no 1373 0.413419142975583 464 16876704
SGTC_1948 st076329 66.6 µM 0.217167291934515 0.419541604939399 no 1374 0.414038986829075 472 24208413
SGTC_1324 1418-0026 34.4 µM 0.21688178809122 0.419656033966327 no 1375 0.414150235405937 437 1372513
SGTC_1863 st057641 20.1 µM 0.216786629471753 0.419694174746617 no 1376 0.414187316161135 472 3921635
SGTC_2724 maprotiline 69.64 µM 0.216340789283712 0.419872883184123 no 1377 0.41436105827643 459 4011 A tricyclic antidepressant.
SGTC_1386 3228-0095 33.8 µM 0.216104860954007 0.419967458249548 no 1378 0.414453005373587 461 870181
SGTC_2711 st079103 59.1 µM 0.215767382542275 0.420102749073219 no 1379 0.414584537193775 466 54693780
SGTC_1187 1391-0724 117 µM 0.215639502376033 0.420154017080744 no 1380 0.414634380843607 432 6997986
SGTC_3177 9107506 49.47 µM 0.215173156001888 0.420340989910596 no 1381 0.414816159571208 465 8897194
SGTC_1552 6-methylflavone 10.6 µM 0.214508352051928 0.420607561651618 no 1382 0.415075327275619 472 689013
SGTC_1751 st044839 27.194 µM 0.214460907898684 0.42062658710553 no 1383 0.415093824356633 440 5291326
SGTC_3323 9138564 53.9225 µM 0.213982645678107 0.420818384116349 no 1384 0.415280295245227 418 43912313 YNL103W MET4
SGTC_3068 9116768 49.47 µM 0.213601767091776 0.420971140915014 no 1385 0.415428810630968 464 41904888
SGTC_2469 5655019 90.81 µM 0.212191786164482 0.421536737291377 no 1386 0.415978707266685 470 2788239
SGTC_212 3807-4682 38.772 µM 0.212015181140378 0.421607591642891 no 1387 0.41604759535356 437 3125501 YBL034C STU1
SGTC_1744 st037937 38.9 µM 0.210564928219006 0.422189532328215 no 1388 0.416613390956936 420 1016152
SGTC_1768 st044301 37.178 µM 0.210082923911224 0.422382983114561 no 1389 0.416801476416544 478 3931349
SGTC_2251 lansoprazole 556 µM 0.209879906415113 0.422464469101671 no 1390 0.416880702654467 463 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_1746 st038117 42 µM 0.208841275413701 0.422881400641814 no 1391 0.417286074294276 471 2898218
SGTC_2781 5567276 71.43 µM 0.207757059361192 0.423316723284089 no 1392 0.417709331320255 428 2853274
SGTC_2966 9084041 48.03 µM 0.207092808312714 0.423583472430642 no 1393 0.417968689246085 414 17741380
SGTC_2864 9034755 47.6 µM 0.206282972520878 0.423908732694615 no 1394 0.418284939233295 428 4930451
SGTC_2330 7979373 200 µM 0.20473800070213 0.424529394627352 no 1395 0.418888414490195 421 1863007
SGTC_253 dyclonine 31.25 µM 0.203008279867771 0.425224497862831 no 1396 0.419564280283484 428 3180 An oral anasthetic.
SGTC_2830 7992007 71.43 µM 0.201558384384595 0.425807330097919 no 1397 0.420130990936769 469 1952075
SGTC_535 2293-4129 48.2 µM 0.201500595149559 0.425830563712268 no 1398 0.420153582056851 470 396118 YIL048W NEO1
SGTC_362 0310-0100 9.03 µM 0.199911082377231 0.426469712930454 no 1399 0.420775061456774 426 790235
SGTC_2307 7538926 6.34 µM 0.198888982575922 0.426880805346673 no 1400 0.421174793990379 450 96582
SGTC_1157 4092-0394 27.6 µM 0.198818532702689 0.426909143484085 no 1401 0.421202349196759 431 3659885
SGTC_1067 clotrimazole 1.36 µM 0.198470066074266 0.427049318127225 no 1402 0.421338651351987 442 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_786 4544-0069 423 µM 0.198058659869844 0.427214822783712 no 1403 0.421499584353636 438 748821 YLR208W SEC13
SGTC_3092 9117248 49.47 µM 0.197229000431376 0.427548625530671 no 1404 0.42182416862515 481 17141857
SGTC_2109 5483026 200 µM 0.19572705943968 0.428153043854507 no 1405 0.422411901830993 486 759335
SGTC_2620 irigenin 100 µM 0.195722844536989 0.428154740273829 no 1406 0.422413551432657 488 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_917 harmaline 728.087 nM 0.195627562486293 0.428193089867353 no 1407 0.422450842675452 431 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_1135 dihydrocapsaicin 536.708 nM 0.194273256383418 0.428738250879498 no 1408 0.422980962498997 453 107982 A Capsaicinoid.
SGTC_1813 st051246 8.6015 µM 0.189419588567256 0.430693151296597 no 1409 0.424881986457094 461 5291959
SGTC_182 3448-4371 550.524 µM 0.189026197956666 0.430851671410979 no 1410 0.425036141959254 454 3491403
SGTC_2738 aclarubicin 5.55 µM 0.187641264663219 0.431409830626094 no 1411 0.425578938115409 467 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_3064 1327-0027 10 µM 0.18657339008853 0.431840301655745 no 1412 0.425997565998508 480 16000455 YPR107C YTH1
SGTC_1152 3909-8331 15.9 µM 0.185270097602492 0.432365781657408 no 1413 0.426508595322589 472 16001939
SGTC_2840 9008771 71.43 µM 0.184638243186318 0.432620584834165 no 1414 0.426756393952858 463 2992978
SGTC_1104 tacrolimus 29.8 µM 0.184426309828575 0.43270605588583 no 1415 0.426839515774257 451 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_1369 1866-0067 208 µM 0.184420356989206 0.432708456664478 no 1416 0.42684185056856 457 3531355
SGTC_1973 st070275 50.2 µM 0.183625332971788 0.433029111939178 no 1417 0.42715369410068 473 17118334
SGTC_342 k048-0088 23.3 µM 0.183539456715137 0.433063750862137 no 1418 0.427187381289204 456 6820570
SGTC_3136 9095672 49.47 µM 0.183143234527947 0.433223577128102 no 1419 0.427342816589324 472 17217380
SGTC_2208 7283366 200 µM 0.181988230642677 0.433689539463862 no 1420 0.427795981126621 471 898663
SGTC_2107 5363541 170.161 µM 0.181428406409752 0.433915422132219 no 1421 0.428015661877999 488 244052
SGTC_2872 9044037 25.97 µM 0.181319085740603 0.433959534291619 no 1422 0.42805856303222 449 6465195
SGTC_2167 5876490 200 µM 0.18124131197266 0.433990917410802 no 1423 0.428089084625596 470 686534
SGTC_1682 st012968 530 nM 0.181168182809977 0.434020426727481 no 1424 0.428117783879207 444 24207270
SGTC_901 1112-0062 60.1 µM 0.179583230965348 0.434660081704795 no 1425 0.428739885198126 480 1908457
SGTC_1193 1488-0126 41.5 µM 0.177953835240057 0.435317851673894 no 1426 0.429379615554802 440 1384710
SGTC_1310 1188-0297 994 nM 0.177913351585553 0.435334196787348 no 1427 0.429395512541653 463 1588352
SGTC_2685 mycophenolic acid 18.85 µM 0.177725832594504 0.435409908270053 no 1428 0.429469148368683 472 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_2418 pentamidine 31.67 µM 0.177293308025376 0.43558455068118 no 1429 0.429639003476633 468 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1213 1315-0166 115 µM 0.176783787751785 0.435790298112644 no 1430 0.429839111987874 425 768401
SGTC_3107 9121808 49.47 µM 0.176565921052368 0.435878279338418 no 1431 0.429924682254302 438 662681
SGTC_2211 7117706 200 µM 0.176500111717579 0.435904855781538 no 1432 0.429950530460557 478 822771
SGTC_1480 1070-0044 41.2 µM 0.175799658950426 0.436187744552529 no 1433 0.430225668791308 452 3124987
SGTC_2323 6148992 148.28 µM 0.175563158055402 0.436283266505632 no 1434 0.430318574164098 431 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_2681 menadione 3.18 µM 0.175428685659912 0.436337581132533 no 1435 0.43037140108872 477 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_2125 5246583 200 µM 0.175014176469528 0.436505012723647 no 1436 0.430534247147753 476 835267
SGTC_2355 9061122 103.12 µM 0.173696998445595 0.437037132300691 no 1437 0.431051798280605 472 5302957
SGTC_66 0109-0187 42.4 µM 0.173664361524781 0.43705031856298 no 1438 0.431064623623989 401 759417
SGTC_848 0368-0089 85.6 µM 0.173546004948308 0.437098138638082 no 1439 0.431111134863292 496 762535
SGTC_1628 st004252 77.7 µM 0.173515238187763 0.437110569604402 no 1440 0.431123225604044 447 692968
SGTC_1646 st011709 75.6 µM 0.173486024828637 0.437122372993679 no 1441 0.431134705947878 482 5757843
SGTC_1557 sumaresinolic acid 42.3 µM 0.172577442217656 0.437489505335423 no 1442 0.431491792165267 436 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_3223 9129970 49.47 µM 0.171849006552806 0.437783884321558 no 1443 0.431778118461939 455 17248386
SGTC_1870 st057514 26.5 µM 0.171760133989385 0.437819802297213 no 1444 0.43181305406776 476 5393161
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.171227263738978 0.438035173318372 no 1445 0.43202253534631 469 551469
SGTC_1056 3448-1962 115 µM 0.169375091807256 0.438783910990776 no 1446 0.43275080714548 462 715507
SGTC_1488 4013-0813 75.9 µM 0.167476158930748 0.439551779178156 no 1447 0.4334977025007 466 2910057
SGTC_497 capsazepine 133 µM 0.167364095527268 0.439597101198423 no 1448 0.433541787145458 456 2733484 A calcium channel blocker.
SGTC_2304 7443016 91.4 µM 0.16712808368115 0.439692554517159 no 1449 0.433634634596638 491 939854
SGTC_2731 amoxapine 43.43 µM 0.166316837142637 0.440020684134762 no 1450 0.433953808227437 492 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_2361 9034121 116 µM 0.165960244309009 0.440164930366328 no 1451 0.434094118340067 459 6496917
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.165122896705612 0.440503679062553 no 1452 0.434423625707672 472 2333 A French combination drug.
SGTC_707 0865-0008 204 µM 0.164518353554427 0.44074827387841 no 1453 0.434661549776331 485 723043
SGTC_2094 5332512 191.667 µM 0.164424595355729 0.440786209954394 no 1454 0.434698451385067 483 755774
SGTC_1292 0kpi-0043 232 µM 0.162304191391654 0.441644303976981 no 1455 0.43553315709585 483 3333905
SGTC_77 0828-0286 12.516 µM 0.162220884403697 0.441678022619744 no 1456 0.435565957122753 437 745345
SGTC_194 1486-1323 56.904 µM 0.161125233555854 0.442121528376583 no 1457 0.435997383198391 475 5178754
SGTC_1637 st007924 17.4 µM 0.160451000483892 0.442394485589206 no 1458 0.436262908701849 476 683336
SGTC_2605 digitonin 300 nM 0.158228493533892 0.443294440570827 no 1459 0.437138375986325 480 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_2406 ethylparaben 405.7 µM 0.158139090403387 0.443330648541601 no 1460 0.437173599226918 424 8434 A possible steroid mimic.
SGTC_2266 7929956 200 µM 0.156542872682593 0.443977190773697 no 1461 0.437802564129424 495 2967153
SGTC_549 1661-1316 519 µM 0.155442304251945 0.444423059013215 no 1462 0.438236317739504 476 2857282
SGTC_1962 st076595 64.5 µM 0.155427334122504 0.444429124279248 no 1463 0.438242218246745 460 279619
SGTC_3343 9148379 18.9835 µM 0.152438582834566 0.445640299224841 no 1464 0.439420513974886 477 1955036
SGTC_2508 celastrol 40.54 µM 0.151807293953746 0.445896190853449 no 1465 0.439669464536359 460 122724 Celastrol is a natural product and antioxidant.
SGTC_114 0364-0001 490.298 µM 0.151755331748741 0.445917254630007 no 1466 0.439689957043432 434 4003655
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.150340530999598 0.446490826989467 no 1467 0.440247978622247 471 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_794 k038-0031 316 µM 0.150081485207906 0.446595858538145 no 1468 0.440350163595945 488 6624242
SGTC_3311 9131146 2.8755 µM 0.149290844661983 0.446916451256395 no 1469 0.440662069608899 463 4900406 YPR165W RHO1
SGTC_3306 9127676 59.7925 µM 0.148725155908577 0.44714585074701 no 1470 0.440885255224677 451 41905287
SGTC_2825 7998094 58.44 µM 0.148381414999688 0.447285254046038 no 1471 0.441020883194915 491 2987815
SGTC_2060 5238662 140 µM 0.147797421775519 0.447522106016121 no 1472 0.441251322058946 457 790130
SGTC_564 3555-0129 330 µM 0.147794809805234 0.447523165403232 no 1473 0.441252352765412 493 563260
SGTC_1476 4112-3294 3.34 µM 0.147514489862808 0.447636862337432 no 1474 0.441362971793462 495 704369
SGTC_2417 cerulenin 830 nM 0.147169901832716 0.44777663211111 no 1475 0.441498958371294 500 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_3339 9145883 14.936 µM 0.14492560925815 0.448687106767782 no 1476 0.442384803313878 490 2030670
SGTC_1510 1123-0200 71.5 µM 0.143655599233482 0.44920245019189 no 1477 0.442886217051869 481 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_148 3253-0744 288.01 µM 0.143579984734321 0.449233135681099 no 1478 0.44291607337012 489 6893655
SGTC_1871 st057448 67.3 µM 0.143118565550615 0.449420393026548 no 1479 0.443098271345521 494 691747
SGTC_595 3909-8003 73.7 µM 0.141452933330523 0.450096448529835 no 1480 0.443756069927731 491 699517
SGTC_2213 7173844 200 µM 0.140657221478952 0.450419467459015 no 1481 0.444070370667751 475 892728
SGTC_3163 9099914 49.47 µM 0.139004185658651 0.451090621485459 no 1482 0.44472342074205 487 16268368
SGTC_177 1327-0068 8.361 µM 0.138608116746482 0.451251451451967 no 1483 0.444879914496782 471 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_3294 9122953 26.2835 µM 0.138362011213233 0.451351390479695 no 1484 0.444977159426906 499 16459826
SGTC_539 4859-0462 2.54 µM 0.137864424463669 0.451553460916729 no 1485 0.445173783517951 455 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_2204 7233102 200 µM 0.137564264419101 0.451675362260817 no 1486 0.445292399906107 485 2172480
SGTC_3189 9110682 49.47 µM 0.137492542304404 0.451704490803814 no 1487 0.445320743571704 480 17122418
SGTC_2531 methyl deoxycholate 70.07 µM 0.137217686803126 0.451816120430072 no 1488 0.445429365549369 488 16667744 Haematoxylin.
SGTC_748 act1.228 77.9 µM 0.136640958616737 0.452050364796765 no 1489 0.445657299912891 456 4421505 YNR035C ARC35
SGTC_2809 7964133 12.99 µM 0.136162393858796 0.452244751705788 no 1490 0.445846451792057 479 1253665
SGTC_2085 5307070 144.047 µM 0.135002785444297 0.452715817260121 no 1491 0.446304836014426 483 2840351
SGTC_2563 tomatine 8.54 µM 0.13365293108818 0.453264249855768 no 1492 0.446838513334475 504 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_1155 4088-0394 48.2 µM 0.133586870505333 0.453291091919886 no 1493 0.446864633472028 477 2326248
SGTC_1842 st055362 61.2 µM 0.133282876863721 0.453414614874808 no 1494 0.446984834529022 456 676032
SGTC_2786 7743617 45.45 µM 0.133238425296087 0.453432677436465 no 1495 0.447002411375499 470 583674
SGTC_963 1269-2853 151 µM 0.13276372069814 0.453625576095434 no 1496 0.447190123498079 453 3668223
SGTC_2870 9038528 12.99 µM 0.132502932503107 0.453731553381408 no 1497 0.447293251837762 481 6463316
SGTC_2282 7944268 200 µM 0.132397568620197 0.45377437135542 no 1498 0.44733491885417 472 2970414
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.132367569320682 0.453786562625786 no 1499 0.447346782430889 463 4330530
SGTC_384 k007-0144 5.16 µM 0.131385959237587 0.454185498361881 no 1500 0.447734997641475 475 6824886
SGTC_123 0083-0120 66.675 µM 0.130729200004023 0.454452437436779 no 1501 0.447994766152572 494 16001701
SGTC_1683 st010134 710 nM 0.13033693658928 0.454611882295205 no 1502 0.448149929064559 474 3818134
SGTC_3030 9087619 49.47 µM 0.128972291553867 0.455166631763208 no 1503 0.44868978691097 508 25236973
SGTC_3115 9123671 49.47 µM 0.128176960067111 0.45548998680396 no 1504 0.449004466428387 507 3286988
SGTC_3043 9092303 49.47 µM 0.126979900759022 0.455976726394777 no 1505 0.449478153317398 465 25236084
SGTC_906 1165-0455 526 µM 0.124523259925051 0.456975834062635 no 1506 0.450450492474293 502 3252859
SGTC_1909 st060837 51.5 µM 0.12425212030299 0.45708612242909 no 1507 0.450557827949693 488 678937
SGTC_3084 9116877 49.47 µM 0.124079560412547 0.457156314366039 no 1508 0.450626140756339 494 27241325
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.123580929643807 0.457359149185969 no 1509 0.450823546331834 439 6708561
SGTC_1730 st033808 45.1 µM 0.123451557083288 0.457411777639077 no 1510 0.450874766309405 510 1045166
SGTC_764 1951-2361 146 µM 0.122567868391333 0.457771280044634 no 1511 0.45122464992847 479 5438930
SGTC_94 0334-0113 514.748 µM 0.12100541644075 0.458407001424899 no 1512 0.451843372511694 508 6795178
SGTC_1402 3909-7673 35.9 µM 0.11980588421443 0.458895132422031 no 1513 0.452318460295882 480 5328014
SGTC_2587 piperic acid 92.2 µM 0.117938393830568 0.45965520170952 no 1514 0.453058235823117 509 5370536
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 0.115412798071355 0.460683354209504 no 1515 0.454058967677223 482 279621
SGTC_2477 5967686 25.23 µM 0.114768343271162 0.460945749658408 no 1516 0.454314370812208 476 776118
SGTC_607 4491-0986 66.8 µM 0.114443189626056 0.461078145290604 no 1517 0.454443239253159 494 698981 YDR232W HEM1
SGTC_513 4245-1575 41.7 µM 0.113616066100292 0.461414951768171 no 1518 0.454771075458801 480 719745
SGTC_1406 3909-7906 11.9 µM 0.111276465935584 0.462367791054132 no 1519 0.455698558476175 494 X1406
SGTC_922 1866-0035 480 µM 0.11006784119231 0.462860107615077 no 1520 0.45617778608535 497 3156169
SGTC_1664 st014217 9.02 µM 0.109201960758033 0.463212847050413 no 1521 0.456521152575983 500 3982782
SGTC_1570 verbenone 133 µM 0.108672681389534 0.463428477347134 no 1522 0.456731055295829 504 29025 A natural terpanoid with antifungal properties.
SGTC_3319 9138450 16.7555 µM 0.107481266409727 0.463913903266284 no 1523 0.457203593231382 508 2029690
SGTC_878 0828-0289 13.7 µM 0.107340694102033 0.463971181109196 no 1524 0.457259350897433 479 745350 YLR208W SEC13
SGTC_984 1492-0255 2.91 µM 0.107205504266107 0.464026266504998 no 1525 0.457312974412717 508 1585198
SGTC_2296 7971656 126.45 µM 0.106112079771526 0.46447182614853 no 1526 0.457746713493525 489 666570
SGTC_291 SEC14.278 35.5 µM 0.105874809507098 0.464568517331964 no 1527 0.457840840406245 500 1068044
SGTC_372 0155-0182 15.9 µM 0.105855768323306 0.464576276990076 no 1528 0.457848394290777 490 771486
SGTC_2019 4016004 108 µM 0.10332986193953 0.465605751973545 no 1529 0.458850588031072 485 45595336
SGTC_2459 5811157 9.22 µM 0.103000429947951 0.465740034555769 no 1530 0.458981314860237 492 2870684 YBR192W RIM2
SGTC_2363 9053361 176 µM 0.10236854109147 0.465997615062939 no 1531 0.459232076517974 498 6469797 YMR079W SEC14
SGTC_2076 5212012 200 µM 0.102007330079125 0.466144864001425 no 1532 0.459375428437629 504 604802
SGTC_3304 9125678 46.087 µM 0.101545186645996 0.466333265151287 no 1533 0.459558844577356 518 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_1993 st073995 70.8 µM 0.10134580820937 0.466414547718007 no 1534 0.459637976833499 497 3098394
SGTC_3344 9148862 3.898 µM 0.101110260649356 0.466510577511545 no 1535 0.459731466485225 496 4905352
SGTC_10 0279-0212 42.575 µM 0.100268097829146 0.466853932665343 no 1536 0.460065742034557 483 39851 YBR002C RER2
SGTC_2676 harmalol 100 µM 0.100146353431339 0.46690357067969 no 1537 0.460114067780897 478 5459187 A monoamine oxidase inhibitor
SGTC_3082 9117008 49.47 µM 0.0994624726931685 0.467182414261485 no 1538 0.46038554128127 499 41448529
SGTC_1216 1165-0504 9.65 µM 0.0993811690512002 0.467215565850477 no 1539 0.460417816829716 483 6304004
SGTC_2996 9066192 71.4286 µM 0.0977765800451671 0.467869883830195 no 1540 0.461054852336765 491 6472854
SGTC_2218 6965428 192.983 µM 0.0976463798081516 0.467922980607087 no 1541 0.461106547346307 493 675684
SGTC_311 1315-0136 58 µM 0.0965974458137527 0.468350765652726 no 1542 0.46152304247779 493 6759207
SGTC_70 0141-0289 43.283 µM 0.0956872115509572 0.468722014647897 no 1543 0.461884498997499 485 352408
SGTC_2662 daunorubicin 22.37 µM 0.0933461194247834 0.469676978833001 no 1544 0.462814296999591 501 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1145 3546-0597 10.2 µM 0.092412075151459 0.470058037534286 no 1545 0.463185322949628 499 875334
SGTC_735 3076-0345 636 µM 0.090569657081238 0.470809762308016 no 1546 0.463917271476997 518 2888990
SGTC_3052 9092717 49.47 µM 0.089661855782449 0.471180192628051 no 1547 0.464277964241705 494 25237534
SGTC_2337 9009472 200 µM 0.0891790687105322 0.471377205133817 no 1548 0.464469799919197 505 5742383
SGTC_2651 TUB2.036 5 µM 0.0889159888483082 0.4714845639486 no 1549 0.464574338309731 485 15992207 YFL037W TUB2
SGTC_572 0960-0087 17.7 µM 0.0884483044934474 0.471675423797295 no 1550 0.464760185134025 504 6796365
SGTC_1207 2099-0101 141 µM 0.0863290482365862 0.472540363473373 no 1551 0.465602423757244 497 5837381
SGTC_2895 9054447 58.44 µM 0.0851003436853715 0.473041898649044 no 1552 0.466090808539191 503 2697450
SGTC_1319 1306-0155 43.7 µM 0.0842340176506288 0.473395543146999 no 1553 0.466435186057045 510 3122360
SGTC_3328 9140624 29.0385 µM 0.0841206883403783 0.473441807064084 no 1554 0.466480238012229 514 4904392
SGTC_1885 st057546 99.9 µM 0.0840894899943106 0.47345454308817 no 1555 0.466492640408684 468 702008
SGTC_2127 5253358 187.912 µM 0.0832083120152816 0.473814275365101 no 1556 0.466842951814641 506 20612
SGTC_718 1130-0073 349 µM 0.0830637365758375 0.473873298918808 no 1557 0.466900430093086 506 6740020
SGTC_666 0272-0154 136 µM 0.082006469459968 0.474304950180564 no 1558 0.467320784450712 512 6870312
SGTC_1318 1280-3875 124 µM 0.0819030453325869 0.474347176856891 no 1559 0.467361906376373 494 373245
SGTC_2636 apigenin dimethyl ether 100 µM 0.0812848333365621 0.474599590470641 no 1560 0.467607717659504 503 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1826 st055655 41.6 µM 0.08030415562779 0.475000018335951 no 1561 0.467997676588784 519 676168
SGTC_2488 5268135 45.7 µM 0.0801586700820018 0.47505942479046 no 1562 0.468055530419303 500 1270356 YLR208W SEC13
SGTC_1267 0828-0272 9.49 µM 0.0798159713729319 0.475199361948012 no 1563 0.468191810766182 497 745334
SGTC_1102 cgs 12066b 26.1 µM 0.0788476102339062 0.475594797790978 no 1564 0.468576917203505 503 6438352 A 5-HT1B full agonist.
SGTC_1165 k072-0275 30.3 µM 0.0783608799734318 0.475793565995957 no 1565 0.468770495532781 519 6153523 YGL055W OLE1
SGTC_2948 9070189 9.45 µM 0.0783459396597229 0.475799667333974 no 1566 0.468776437587677 515 6473636 YDL196W YDL196W
SGTC_2352 9027995 87.8 µM 0.0774988609021826 0.476145607315246 no 1567 0.469113348709224 502 2997347
SGTC_1250 0485-0349 40.2 µM 0.0769490753079771 0.476370144858077 no 1568 0.469332028399383 504 6842794 YDL195W SEC31
SGTC_1407 3909-7909 12.3 µM 0.0764997574379995 0.47655365602428 no 1569 0.469510753473905 520 4411780
SGTC_2091 4-phenylthiadiazole 200 µM 0.0748861108589289 0.477212745016576 no 1570 0.470152663727211 514 270010
SGTC_157 1348-1695 65.819 µM 0.0732834772925121 0.477867397482115 no 1571 0.470790269777191 490 5380510
SGTC_2145 5634607 200 µM 0.0723819066369885 0.478235702324722 no 1572 0.471148991717081 514 308662
SGTC_286 k060-0067 22.9 µM 0.0716357642702041 0.478540526501398 no 1573 0.471445888702952 501 5985051
SGTC_1770 st043884 66.3 µM 0.0708805769527351 0.478849058625368 no 1574 0.47174640091757 522 670149
SGTC_1735 st034310 56.75 µM 0.0708564315050356 0.478858923469156 no 1575 0.471756009398663 528 871153
SGTC_3250 9135583 49.47 µM 0.0707918599614639 0.478885304828256 no 1576 0.471781705190804 476 7699353
SGTC_1763 st044482 94.5 µM 0.0703802513556625 0.479053473868683 no 1577 0.471945504700163 525 88505
SGTC_2820 7989630 71.43 µM 0.0703750241493971 0.479055609548417 no 1578 0.47194758489575 519 2984098
SGTC_3219 9131112 49.47 µM 0.0697645123550609 0.479305050480722 no 1579 0.472190546683189 509 17612988 YMR079W SEC14
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.0696883699681487 0.479336161061127 no 1580 0.472220849348651 491 16623 A steroid.
SGTC_1634 st006576 41 µM 0.0691795455841584 0.479544061915097 no 1581 0.472423352177121 518 3915356
SGTC_428 3448-4153 16.5 µM 0.0688769219754852 0.479667713716027 no 1582 0.472543794240104 503 3834874
SGTC_80 0159-0065 512.242 µM 0.0688446853207371 0.479680885706787 no 1583 0.4725566243496 514 1548079
SGTC_496 calpeptin 138 µM 0.0666339756219449 0.480584240276031 no 1584 0.473436548604054 520 73364 A calpain inhibitor.
SGTC_955 1216-0110 33 µM 0.0657323597352996 0.480952693312166 no 1585 0.473795454386752 514 3619719
SGTC_1867 st057372 64 µM 0.0655788610163121 0.481015423504965 no 1586 0.473856559671622 489 688837
SGTC_2496 diffractaic acid 79.83 µM 0.065264987378553 0.481143695443113 no 1587 0.473981509455301 517 94870 An apoptosis inducer which activates caspases.
SGTC_2364 9055074 200 µM 0.0650495301554869 0.481231748300104 no 1588 0.474067282184947 504 6470630
SGTC_632 0781-2353 4.65 µM 0.0643362726740646 0.481523248211875 no 1589 0.474351235925404 508 6811515 YHR007C ERG11
SGTC_1272 0839-0021 27 µM 0.0612314968331542 0.482792246512997 no 1590 0.475587422970377 519 5027250
SGTC_1004 4084-0029 199 µM 0.0609643054215056 0.482901462549712 no 1591 0.475693818151553 519 716894 YLR208W SEC13
SGTC_486 niguldipine 82 µM 0.0600150793407496 0.483289474526414 no 1592 0.4760718123807 506 1236 A calcium channel blocker.
SGTC_3169 9102970 49.47 µM 0.0593564789230248 0.483558697742799 no 1593 0.476334088347253 520 17027839
SGTC_2338 7999974 200 µM 0.059009876809523 0.48370038505609 no 1594 0.476472120633018 526 315925
SGTC_987 1497-1013 404 µM 0.0587357245733393 0.483812457077241 no 1595 0.476581302174934 527 1676435
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.0582116271939842 0.484026708936581 no 1596 0.476790029633613 525 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_629 3448-6466 76.7 µM 0.0573936083197905 0.484361125574139 no 1597 0.477115827216659 519 573744
SGTC_1103 duloxetine 36.1 µM 0.0568359982755917 0.484589090051928 no 1598 0.477337918898094 497 60835 A selective serotonin reuptake inhibitor.
SGTC_447 ml7 120 µM 0.0559193669263567 0.484963842037267 no 1599 0.477703021196344 514 4216 Selective myosin light chain kinase inhibitor.
SGTC_2387 9077560 195.08 µM 0.0554481726931573 0.48515648843873 no 1600 0.477890709290271 518 5303272
SGTC_2318 6029776 164 µM 0.0550580906152601 0.485315974992989 no 1601 0.478046092157028 526 818325
SGTC_2269 7935389 174.42 µM 0.0545790734723065 0.485511826200476 no 1602 0.478236905426789 507 97605
SGTC_3157 9099274 49.47 µM 0.0539800192078242 0.485756760763006 no 1603 0.478475541695182 528 17217662
SGTC_160 3453-0671 289.699 µM 0.0538555745593368 0.485807642966829 no 1604 0.478525115815428 513 5322268
SGTC_2995 9067767 71.4286 µM 0.0535157645762361 0.485946583670102 no 1605 0.478660485166248 519 11673567
SGTC_1629 st005085 44.9 µM 0.0530319068215859 0.486144425225964 no 1606 0.478853242753425 527 24207091
SGTC_1860 st056228 74.6 µM 0.0529824284064867 0.48616465633712 no 1607 0.478872954073674 529 688679
SGTC_3155 9099265 49.47 µM 0.052709494145709 0.486276256414702 no 1608 0.47898168715448 524 25236499
SGTC_1311 1190-0148 100 µM 0.0522279008971819 0.486473177672375 no 1609 0.479173550782724 526 1961333
SGTC_1574 spiramycin 23.7 µM 0.0520181006793552 0.486558965047866 no 1610 0.479257135341181 526 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_923 1900-2434 73.3 µM 0.0503292761743645 0.487249548238554 no 1611 0.479929997156271 541 5910570
SGTC_568 1193-0097 7.48 µM 0.0492052427116196 0.487709202050711 no 1612 0.48037786662493 506 3646150
SGTC_2369 9071472 200 µM 0.0491998922384855 0.487711390072585 no 1613 0.480379998572713 526 17296037
SGTC_3192 9110362 49.47 µM 0.0487098746623151 0.487911779364133 no 1614 0.480575253188084 527 16649480
SGTC_115 0527-0192 112.043 µM 0.0485492340559368 0.487977472893435 no 1615 0.480639263785879 536 4233931
SGTC_754 3474-0146 171 µM 0.0481703617261101 0.488132412967966 no 1616 0.480790235336642 531 24762078
SGTC_2940 9060638 45.86 µM 0.0472947436875835 0.488490504322689 no 1617 0.481139158663203 507 4027022
SGTC_1927 st060202 13.8 µM 0.0466740501042319 0.488744347816021 no 1618 0.481386506407859 528 688887
SGTC_1771 st048882 4.1505 µM 0.0460126347213967 0.48901485021683 no 1619 0.481650089762454 530 4580403
SGTC_2689 tacrolimus 100 µM 0.0443534529326333 0.489693436162323 no 1620 0.482311332142868 533 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_1732 st034308 51.822 µM 0.0440617462853478 0.489812743908695 no 1621 0.482427592597417 525 830119
SGTC_2193 5925765 200 µM 0.0437624047739094 0.489935175254898 no 1622 0.48254689750064 509 877370
SGTC_2225 6654152 15.4 µM 0.0433179342472304 0.490116966438223 no 1623 0.482724047589244 528 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_2422 chlorphenesin carbamate 384.24 µM 0.0433137568427934 0.490118675032168 no 1624 0.482725712569793 515 2724 A muscle relaxant with antifungal properties.
SGTC_1424 4048-1941 275 µM 0.0397198573951246 0.491588674327976 no 1625 0.484158235128186 537 X1424
SGTC_2859 9028643 45.46 µM 0.0388620265498961 0.491939567319371 no 1626 0.484500196053507 522 17151580
SGTC_3112 9123419 49.47 µM 0.0383009092640665 0.492169093960036 no 1627 0.484723882915922 532 17015854
SGTC_1041 0206-0046 107 µM 0.0379984994404974 0.492292796648794 no 1628 0.484844439219347 527 50494
SGTC_1806 st050005 60.3 µM 0.0373608785610856 0.49255362199653 no 1629 0.485098632631958 526 5194765
SGTC_950 1165-0508 94.1 µM 0.0368871716745741 0.492747398714984 no 1630 0.485287484153945 521 6148369
SGTC_1173 0443-0020 122 µM 0.0368702670042402 0.492754313849107 no 1631 0.48529422355719 523 5331295
SGTC_3194 9111903 49.47 µM 0.0359473970599595 0.493131832263944 no 1632 0.485662151440231 531 17087251
SGTC_3167 9103034 49.47 µM 0.0354602407877694 0.493331115785918 no 1633 0.48585637483862 522 5127859
SGTC_37 0566-0070 1.56 µM 0.0352407937345666 0.493420886667433 no 1634 0.485943866861595 536 1626686
SGTC_1261 0712-0010 12.7 µM 0.0347026728892832 0.493641021271107 no 1635 0.486158414777609 533 2840123
SGTC_2305 7443522 69.23 µM 0.0345324799722936 0.493710644236429 no 1636 0.486226271256947 532 5415886
SGTC_2054 5233173 129 µM 0.034350742524391 0.493784990080235 no 1637 0.486298731019225 533 6889
SGTC_890 0929-0006 47.2 µM 0.034049985438979 0.493908025401327 no 1638 0.486418645585833 510 1378169
SGTC_1065 prochlorperazine maleate 2.48 µM 0.0338426525989217 0.493992842569369 no 1639 0.486501311777676 536 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_1731 st035964 63 µM 0.0338085010047156 0.494006813568494 no 1640 0.486514928500398 512 6739575
SGTC_1328 1441-0025 69.2 µM 0.0336104145305367 0.494087848464652 no 1641 0.486593908683566 510 4562601
SGTC_1540 guanosine 70.6 µM 0.0330149354479265 0.494331453557634 no 1642 0.486831338684542 532 6802 Guanosine is a purine nucleoside
SGTC_2277 7947813 106.88 µM 0.0327703144498655 0.494431526407484 no 1643 0.486928875565041 539 1246798
SGTC_79 0052-0007 94.094 µM 0.0327613465848752 0.494435195109076 no 1644 0.486932451305578 533 2801472
SGTC_3293 9120939 62.045 µM 0.0319828977112531 0.494753655791393 no 1645 0.487242844784858 525 934087
SGTC_2431 5490079 200 µM 0.0297517278857834 0.495666437305125 no 1646 0.488132528636185 536 5722345
SGTC_446 go6976 132 µM 0.02969496067452 0.495689661340329 no 1647 0.488155165475121 536 3501 A protein kinase C inhibitor.
SGTC_2984 9022109 38.96 µM 0.0296610644472469 0.495703528633677 no 1648 0.488168682159372 534 6459207
SGTC_1905 st060207 84.5 µM 0.0296370780219393 0.495713341728799 no 1649 0.488178247153521 525 1948547
SGTC_2954 9074818 52.69 µM 0.0289910544260263 0.495977637631846 no 1650 0.488435862565481 532 16648742
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.0287923092378838 0.496058947002289 no 1651 0.488515117338883 526 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_2664 lyso-paf C-16 73.48 µM 0.0287143270593538 0.496090850621324 no 1652 0.488546214869359 521 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_3063 1327-0034 4 µM 0.0286157028236802 0.496131199235482 no 1653 0.48858554408543 528 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_2645 abamectin 100 µM 0.0284072576751988 0.496216477317534 no 1654 0.488668667875434 539 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_556 4058-0063 51.5 µM 0.0280592105937685 0.496358869058026 no 1655 0.488807463242092 533 6615692
SGTC_487 nimodipine 119 µM 0.027518874683047 0.496579930208871 no 1656 0.489022942863803 536 4497 L-type voltage-gated calcium channels inhibitor
SGTC_3026 9090633 49.47 µM 0.0270161714227394 0.496785596109213 no 1657 0.489223417904488 533 25236842
SGTC_2233 sulbentine 40.3845 µM 0.0267645391020245 0.496888544219742 no 1658 0.489323768388237 531 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.0266809606037646 0.49692273799927 no 1659 0.489357099481834 535 4000243
SGTC_2113 5491891 107.031 µM 0.0261039753677382 0.497158795798622 no 1660 0.489587203129734 532 789979
SGTC_450 aminopyrene 156 nM 0.0259216241537144 0.497233400043638 no 1661 0.489659926130045 539 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_2101 5377231 179.231 µM 0.0256545676586968 0.497342659419844 no 1662 0.489766430836765 533 2844213
SGTC_3061 glucosamine 200 µM 0.0255823425980286 0.497372208501999 no 1663 0.489795235013447 533 91431 and experimental redox chemotherapeutic
SGTC_2925 9010536 32.5 µM 0.0248456971962677 0.497673589389916 no 1664 0.490089020601764 533 2994177
SGTC_1117 retinoic acid 1.10837 µM 0.0246836813467592 0.497739874492758 no 1665 0.49015363575721 536 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_625 k213-0058 121 µM 0.0244878986510552 0.497819974616421 no 1666 0.490231718149723 539 3655420
SGTC_2170 morpholine 200 µM 0.0237075963417477 0.498139218745437 no 1667 0.490542923352735 537 121171 Reacts with secondary amines.
SGTC_674 0498-0004 451 µM 0.0227923500271713 0.498513673853714 no 1668 0.490907955117515 533 4231473
SGTC_657 3534-0529 86.7 µM 0.0226559660169675 0.498569472821085 no 1669 0.490962350419178 535 1049549
SGTC_2835 9006588 71.43 µM 0.0217758953324312 0.498929537909426 no 1670 0.491313361182712 535 2345538
SGTC_293 4049-0273 38.5 µM 0.0211853175816237 0.499171162678784 no 1671 0.491548913263879 531 1380311
SGTC_851 0394-0702 453 µM 0.0209422061883537 0.499270627633909 no 1672 0.491645879163861 533 762646
SGTC_1363 1636-0063 10.4 µM 0.0200517046032201 0.499634961784396 no 1673 0.492001063266472 539 6072185
SGTC_3216 9129716 49.47 µM 0.019785738611685 0.499743777490117 no 1674 0.492107147298534 538 8056934
SGTC_71 0417-1750 47.813 µM 0.0195966068261005 0.499821157728901 no 1675 0.492182585337583 541 6811472
SGTC_1701 st028638 40.4 µM 0.019503250984455 0.499859352777921 no 1676 0.492219821813359 534 3490878
SGTC_1327 1436-0082 2.18 µM 0.019501810359892 0.499859942186424 no 1677 0.49222039643012 523 15992205
SGTC_1632 st005650 90 µM 0.0193452397496144 0.499924000549407 no 1678 0.492282847284732 532 2759605
SGTC_143 4032-1194 15.74 µM 0.0189737260415265 0.499924000549407 no 1679 0.492431032608926 541 1806963
SGTC_1437 4092-1038 11.6 µM 0.0189072535404218 0.499896804387566 no 1680 0.492457546543836 539 3977136
SGTC_722 3534-0461 190 µM 0.0185255169234833 0.499740622962646 no 1681 0.49260981074774 535 658262
SGTC_1497 4476-2978 41.3 µM 0.0168728444273374 0.499064459236483 no 1682 0.493269028345431 539 1528379
SGTC_685 1278-0033 54.9 µM 0.0165350450947977 0.49892625447177 no 1683 0.493403771981317 545 3590572
SGTC_1301 naphtanilide LB 4.81 µM 0.0158824851808216 0.498659271229093 no 1684 0.493664071521156 541 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_3118 9124250 49.47 µM 0.0153981179681696 0.498461101410078 no 1685 0.493857282446655 537 1504786
SGTC_247 mechlorethamine 29.705 µM 0.0122538398942416 0.497174690038504 no 1686 0.495111547508118 543 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_2245 6637752 200 µM 0.0116168839878178 0.496914096855491 no 1687 0.49536563804704 534 681890
SGTC_3007 9078383 71.4286 µM 0.0100555621615485 0.496275330297615 no 1688 0.495988478704382 538 6496995
SGTC_628 1636-0253 16 µM 0.00949972407302313 0.496047928547183 no 1689 0.496210215416575 538 4456143
SGTC_3079 9117512 49.47 µM 0.00914641413285654 0.495903384781576 no 1690 0.496351159563521 543 7185044
SGTC_1434 4073-0095 163 µM 0.00868391009539295 0.495714169083516 no 1691 0.496535664644889 545 24133745
SGTC_1031 k035-0009 16 µM 0.00837297899408069 0.495586964148734 no 1692 0.496659703695962 544 5180959
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.00822963327418822 0.495528320172206 no 1693 0.496716888393912 534 803109
SGTC_2490 carminic acid 95.39 µM 0.00784438458899932 0.49537071207814 no 1694 0.49687057541828 544 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_1491 4138-0063 26.5 µM 0.00734085160982566 0.495164714095449 no 1695 0.497071450221043 546 23883227
SGTC_2499 avocadenofuran 51.48 µM 0.00655480338103413 0.494843140240335 no 1696 0.497385030517156 533 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_1408 3909-7976 48.8 µM 0.00641647968046208 0.494786552086908 no 1697 0.497440212529064 547 24152374
SGTC_317 4495-0002 170 µM 0.00539606594096104 0.494369104677 no 1698 0.497847291595246 545 15991618
SGTC_924 2046-0044 21.3 µM 0.00465881220054682 0.494067500764723 no 1699 0.49814140956006 547 3623589
SGTC_2288 7946289 167.31 µM 0.00386557443685754 0.493742998081261 no 1700 0.498457862759706 545 1246052
SGTC_675 1309-0189 238 µM 0.00385339254877077 0.49373801466975 no 1701 0.498462722593724 541 4246530
SGTC_475 α-linolenic acid 10 µM 0.00383998908120109 0.493732531531147 no 1702 0.49846806976408 545 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_459 nigericin 15.3 µM 0.00368738928432032 0.493670105542472 no 1703 0.498528947843796 546 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_2994 9053520 71.4286 µM 0.0036306197430898 0.493646882125496 no 1704 0.498551595462422 545 4647384
SGTC_2560 caryophyllene 100 µM 0.00232583096983113 0.493113122169906 no 1705 0.499072128525619 546 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_2746 daunorubicin 9.88 µM 0.00211895680572938 0.49302849567602 no 1706 0.499154659172444 545 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_3298 9116858 71.43 µM 0.00207363575970325 0.493009956132425 no 1707 0.499172739614167 545 2506942
SGTC_2753 fluvastatin 17.09 µM 0.00190362562982761 0.492940409986036 no 1708 0.499240563708879 546 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.00121878291822191 0.492660263159652 no 1709 0.499513776083666 547 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_2596 sinensetin 100 µM 0.000990472484143134 0.492566869602126 no 1710 0.499604858713109 544 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_532 1548-0774 215 µM 0.000441286952672057 0.49234221930319 no 1711 0.499823951982503 548 5932993
SGTC_996 3970-0799 1.8 µM 0.000328659066613266 0.492296147942467 no 1712 0.499868884004851 538 6615648 YGL040C HEM2
SGTC_1647 st011722 22.4 µM -5.77248650134804e-05 0.492138095210384 no 1713 0.499976971110728 549 2854783
SGTC_991 3996-0057 64.7 µM -0.00105945152502109 0.491728338546666 no 1714 0.499577340071702 550 715343
SGTC_826 1683-5028 118 µM -0.00112135109067317 0.49170301878817 no 1715 0.499552645732509 550 722377
SGTC_2882 9058044 58.44 µM -0.00137719627670247 0.491598366740417 no 1716 0.499450578350491 547 18076804
SGTC_2401 5128683 200 µM -0.00231353773972256 0.491215366468065 no 1717 0.499077032801677 551 708373
SGTC_3218 9131285 49.47 µM -0.00255168333788549 0.491117956884048 no 1718 0.498982026735007 551 17156417
SGTC_408 cantharidin 100 µM -0.00309014545471698 0.490897709673949 no 1719 0.498767212287505 550 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_464 bw-b 70c 158 µM -0.00425676315958189 0.490420537534202 no 1720 0.498301802326555 551 5353454
SGTC_2239 6685329 187.64 µM -0.00541864075289567 0.48994531782895 no 1721 0.497838285679958 555 805680
SGTC_288 1315-0019 35.1 µM -0.00567522526838167 0.489840374063361 no 1722 0.497735924843271 553 6811474
SGTC_2860 9025725 38.96 µM -0.00851785838071334 0.488677778069813 no 1723 0.496601907244332 552 40546248
SGTC_2760 etidronate 98.04 µM -0.00901724902582506 0.488473544144254 no 1724 0.496402686860812 551 3305 A chelator and antioxidant.
SGTC_1182 1222-0449 220 µM -0.00913597513349339 0.488424989614469 no 1725 0.496355323947738 555 658318
SGTC_2854 9024559 71.43 µM -0.00979190833618443 0.488156740621717 no 1726 0.496093656183311 555 3163529
SGTC_2950 9072895 21.46 µM -0.00992393734332608 0.488102746974617 no 1727 0.496040986789393 556 17332245
SGTC_1877 wortmannin 25 µM -0.0103980774420248 0.487908847804648 no 1728 0.495851842023439 556 312145 A covalent inhibitor of PI 3-kinase.
SGTC_914 3820-6779 408 µM -0.0106466919350754 0.487807178268995 no 1729 0.495752664681535 552 2893481
SGTC_2118 5526350 200 µM -0.0114101999794391 0.487494950816632 no 1730 0.495448087571514 558 743594
SGTC_3201 9113999 49.47 µM -0.0114398448032585 0.487482828075016 no 1731 0.495436261769741 562 16649224
SGTC_2256 7954252 200 µM -0.0122537661279642 0.487149993483154 no 1732 0.495111576934395 569 2972920
SGTC_1678 st019265 80.2 µM -0.0126552958910293 0.486985800312183 no 1733 0.494951402159409 552 5367020
SGTC_975 1335-0046 28.5 µM -0.012912740834085 0.486880527328434 no 1734 0.494848704879342 561 16486740
SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.012938492530412 0.486869997135223 no 1735 0.494838432297049 556 165506
SGTC_1985 st071382 65.5 µM -0.0140587652050955 0.486411912480352 no 1736 0.494391548900738 575 6123237
SGTC_1609 st001574 46.4 µM -0.014237295819764 0.486338912130608 no 1737 0.494320332618219 554 3960012
SGTC_2910 7948405 25.97 µM -0.0145771869803508 0.486199933460916 no 1738 0.494184749736284 552 2971328
SGTC_337 1315-0038 354 µM -0.0148821871337875 0.486075222860312 no 1739 0.494063085479099 558 1626437
SGTC_2545 solidagenone 89.61 µM -0.0159870635167744 0.485623464751688 no 1740 0.493622356097814 560 6708572 An anti ulcer agent
SGTC_29 0299-0004 12.984 µM -0.0167513988933344 0.48531095665677 no 1741 0.493317471257065 556 16871 A napthoquinone isolated from Swertia calycina.
SGTC_941 3237-0776 460 µM -0.0170640354224057 0.485183133883705 no 1742 0.493192765153925 559 760008
SGTC_2817 7995342 71.43 µM -0.0174522002330766 0.485024433171916 no 1743 0.493037932859702 563 18879975
SGTC_399 oxolinic acid 75 µM -0.018372645427725 0.484648119798274 no 1744 0.492670787272677 559 4628 A DNA gyrase inhibitor.
SGTC_1374 2889-5571 141 µM -0.0185176297387185 0.484588845877224 no 1745 0.492612956739556 556 2853281
SGTC_2928 9011484 9.79 µM -0.0185751150606035 0.484565344253158 no 1746 0.492590027357982 561 2994751
SGTC_133 0724-0033 378.92 µM -0.0185765740268463 0.484564747787226 no 1747 0.492589445415074 556 280309
SGTC_2018 5133068 143 µM -0.0186178870308417 0.484547857897814 no 1748 0.492572966760926 559 785362
SGTC_3331 9141060 1.957 µM -0.0186807942279695 0.484522139763093 no 1749 0.492547874784102 563 4906567 YPR165W RHO1
SGTC_1285 0929-0069 65.5 µM -0.0187661529788106 0.484487242939267 no 1750 0.492513827537868 558 1206237
SGTC_1487 3970-0795 2.82 µM -0.020456945229607 0.483796028984459 no 1751 0.491839428805649 558 3765103
SGTC_2628 lathosterol 100 µM -0.0218415264223536 0.483230033556092 no 1752 0.491287184391879 561 6710616
SGTC_2264 7948757 110.76 µM -0.0218612626405745 0.483221965936174 no 1753 0.491279312659511 558 2971411
SGTC_782 0083-0095 30.5 µM -0.0222518717417322 0.483062297161201 no 1754 0.491123520075484 585 3591729 An indicator and reagent.
SGTC_1692 fluoroquinolonic acid 71 µM -0.0235060632050519 0.482549641436379 no 1755 0.490623301042072 575 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_2283 7944793 200 µM -0.0258783691601715 0.481580031573316 no 1756 0.489677176588947 556 2970533
SGTC_2512 diallyl trisulfide 49.23 µM -0.0264617298762889 0.48134161661151 no 1757 0.489444529018347 556 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_2103 5378138 10 µM -0.026626559124141 0.48127425339263 no 1758 0.489378794824367 563 244142
SGTC_1442 4112-3290 3 µM -0.0273793932556294 0.48096658830443 no 1759 0.489078566943419 557 704353
SGTC_1695 st026914 34.495 µM -0.028402651142291 0.480548425784703 no 1760 0.488670504874944 565 3289191
SGTC_1020 4335-0961 93.3 µM -0.0285924949794463 0.480470846922386 no 1761 0.488594798888842 594 669075
SGTC_1642 st009582 77.7 µM -0.0287621222586199 0.480401530094608 no 1762 0.488527155215745 566 6739311
SGTC_1600 coumarin 106 71.1 µM -0.0288622471878762 0.480360615122946 no 1763 0.488487227724342 562 100336 A hepatotoxic, DNA x-linker.
SGTC_3325 9138760 55.175 µM -0.0290531555955891 0.480282603036385 no 1764 0.488411098214771 566 43844959
SGTC_118 0083-0097 135.343 µM -0.0295846783893001 0.48006540756858 no 1765 0.48819914241992 562 5207356
SGTC_2624 nerol 100 µM -0.0302210192740491 0.479805388210246 no 1766 0.487945392614937 567 637566 A natural product oil.
SGTC_2050 5263056 171 µM -0.0308880077840717 0.479532854953702 no 1767 0.487679426881573 571 763468 YGL055W OLE1
SGTC_2988 9073640 71.4286 µM -0.0308890490153951 0.479532429511296 no 1768 0.48767901168849 561 9102229
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.0326243383135355 0.47882343093354 no 1769 0.486987080495497 565 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_92 0063-0024 660.874 µM -0.0327034800315816 0.478791097061182 no 1770 0.486955524356635 552 3594437
SGTC_1458 k015-0034 6.33 µM -0.0333688826377492 0.478519247966463 no 1771 0.486690211947506 582 3598957
SGTC_1405 3909-7894 12 µM -0.0340086464093378 0.478257882995301 no 1772 0.486435127926595 562 7104060
SGTC_886 0866-0150 153 µM -0.0347000827321023 0.477975418569765 no 1773 0.486159447478852 560 271463
SGTC_356 1634-0012 32.5 µM -0.0348281320780379 0.477923109272187 no 1774 0.48610839404028 565 735457
SGTC_1007 4101-0031 70 µM -0.0350696310292729 0.477824455836807 no 1775 0.48601210871877 585 1146276
SGTC_1505 k297-0037 20.6 µM -0.0366552019150411 0.477176776843227 no 1776 0.485379964155413 564 4089396
SGTC_2758 dehydroepiandrosterone 69.35 µM -0.0368281302095383 0.477106142163506 no 1777 0.485311022297086 577 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_1268 0828-0275 2.46 µM -0.0376106079895767 0.476786538554326 no 1778 0.484999074977368 577 745337
SGTC_962 1254-0300 21.5 µM -0.0384499329067763 0.476443732294913 no 1779 0.48466447484456 567 7340576
SGTC_974 1326-0144 138 µM -0.0385648260952593 0.476396807713539 no 1780 0.484618673064419 574 5411856
SGTC_2892 9047358 58.44 µM -0.039358046042891 0.476072850441505 no 1781 0.484302464190545 565 6466771
SGTC_225 nsc-122657 1.016 µM -0.0406173072028103 0.475558590837117 no 1782 0.483800493194797 575 275685
SGTC_98 0074-0023 107.663 µM -0.0413597354365991 0.475255415524668 no 1783 0.483504555889458 592 3563821
SGTC_387 norethindrone acetate 66.7 µM -0.0448276501113587 0.473839463001991 no 1784 0.48212234281959 583 541197
SGTC_695 3505-6186 243 µM -0.0455167312051379 0.473558149386613 no 1785 0.481847719573114 572 1819379
SGTC_990 3985-0011 41.3 µM -0.0472469868378557 0.472851840351203 no 1786 0.481158189615192 583 5399565 YGL099W LSG1
SGTC_631 k072-0230 41.5 µM -0.047850242293529 0.472605604912269 no 1787 0.480917797413186 581 5773147
SGTC_3132 9126706 49.47 µM -0.0479841483362157 0.472550948865008 no 1788 0.480864437924603 570 850858
SGTC_2317 5986382 200 µM -0.048071941210401 0.472515114978566 no 1789 0.480829454007041 568 877883
SGTC_156 3474-0145 5.642 µM -0.0491521184055087 0.472074243881379 no 1790 0.480399034543512 568 2265471
SGTC_2081 5214970 32.255 µM -0.0498472058290218 0.471790564082545 no 1791 0.480122074301479 577 2063512
SGTC_745 0469-0705 296 µM -0.0514597764129063 0.471132495460804 no 1792 0.479479576566585 587 3486736
SGTC_3186 9110464 49.47 µM -0.0515669809598258 0.471088749484301 no 1793 0.47943686484831 565 17018021
SGTC_1356 1502-0781 85.8 µM -0.0521243809505239 0.470861302015094 no 1794 0.479214793090077 575 567702
SGTC_1131 3454-3128 32.3 µM -0.0523537953583877 0.470767692056911 no 1795 0.479123394777814 566 710982
SGTC_3287 9117173 37.0625 µM -0.0537138888767478 0.470212754605087 no 1796 0.47858155852696 571 2789709
SGTC_1923 st058458 19.1 µM -0.0556134969647779 0.469437784607417 no 1797 0.477824856061667 582 3534982
SGTC_2968 9090663 33.37 µM -0.0559775498583414 0.469289277590464 no 1798 0.477679845865239 591 25236811
SGTC_2215 7188065 200 µM -0.056488518176118 0.469080847011479 no 1799 0.477476321044488 569 940217
SGTC_1758 st042942 75.2445 µM -0.0565241404840002 0.469066316527116 no 1800 0.477462132469653 571 669317
SGTC_3037 9091026 49.47 µM -0.0575296901132221 0.468656165809857 no 1801 0.47706162798823 587 25236398 YIL048W NEO1
SGTC_1214 0358-0031 63.7 µM -0.0586117315211856 0.468214852251255 no 1802 0.476630683173016 623 4301366
SGTC_1069 diphenylcyclopropenone 8.49 µM -0.0586482036168211 0.468199977684333 no 1803 0.4766161578986 595 65057 A dermal irritant. YDR527W RBA50
SGTC_17 0960-0276 49.807 µM -0.058881163968126 0.468104969540657 no 1804 0.476523380496941 570 6821114
SGTC_54 0159-0055 9 µM -0.0589205809031805 0.468088894324505 no 1805 0.476507682668954 578 3319099
SGTC_970 1315-0089 19.5 µM -0.0609631811470675 0.467255942459477 no 1806 0.475694265839454 567 6811083 YLR033W RSC58
SGTC_144 4161-2749 112.381 µM -0.0631810327118763 0.466351687322694 no 1807 0.474811174151497 570 797501 YMR168C CEP3
SGTC_2720 fluspirilene 36.88 µM -0.0652962457706041 0.465489441346207 no 1808 0.473969065704253 583 3396 An atypical antipsychotic.
SGTC_758 0868-0029 16 µM -0.0658193502005631 0.465276227754662 no 1809 0.473760825204201 571 762687
SGTC_2046 4110841 106 µM -0.066855241766898 0.464854035299619 no 1810 0.473348472584853 582 44119630 YMR134W ERG29
SGTC_65 0798-0905 34.986 µM -0.0683383697159698 0.464249634236631 no 1811 0.472758140445185 601 3602145
SGTC_1093 fluphenazine 7.97 µM -0.0692214643839131 0.463889796516638 no 1812 0.472406668988891 597 6602611 An atypical antipsychotic.
SGTC_3178 9107506 49.47 µM -0.0695141096956452 0.463770557793862 no 1813 0.472290200954335 582 8897194
SGTC_1240 0356-0016 42.1 µM -0.0695623864047665 0.463750887696732 no 1814 0.472270987843263 585 4305613
SGTC_2621 lithochol-11-enic acid 100 µM -0.0705896111983745 0.46333237130989 no 1815 0.471862189424877 591 6708711
SGTC_547 1120-0019 610 nM -0.0706882305258174 0.46329219352278 no 1816 0.471822944042184 581 3676939
SGTC_2073 5212005 126 µM -0.072160340318247 0.462692496650809 no 1817 0.471237153349272 581 691789
SGTC_3101 9120531 49.47 µM -0.0724644105074233 0.462568637374011 no 1818 0.471116163641367 595 24824904
SGTC_474 dl-dihydrosphingosine 5 µM -0.0733441500906983 0.462210306684473 no 1819 0.47076612979516 597 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_1254 0550-0035 264 µM -0.0741172772592471 0.461895426086434 no 1820 0.470458533903628 584 15121435
SGTC_12 0849-0099 9.267 µM -0.0776967245775315 0.460437896795485 no 1821 0.469034649819968 574 6071388
SGTC_1205 4161-2785 76 µM -0.0789284840264697 0.459936453705685 no 1822 0.468544753466834 631 3498106
SGTC_2028 5153890 36.43 µM -0.0793381508751881 0.45976969446796 no 1823 0.468381830957621 603 2830968 YPR165W RHO1
SGTC_1047 2043-3044 82 µM -0.0807388126718406 0.459199593861007 no 1824 0.467824834755139 601 669592
SGTC_696 1560-0013 611 µM -0.0825953802600198 0.458444058913793 no 1825 0.467086637371752 593 1650269
SGTC_2241 6772625 37.8075 µM -0.0828166349693852 0.458354028698734 no 1826 0.46699867088656 576 2285411
SGTC_1655 st012546 55.1 µM -0.0839345773906519 0.457899162233719 no 1827 0.466554223883307 589 720985 YLR208W SEC13
SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.0844182313942416 0.457702390986584 no 1828 0.466361956234396 601 16486 A toxic proline analog.
SGTC_749 1000-0129 128 µM -0.0846623970341161 0.457603057839435 no 1829 0.466264895706882 600 708470
SGTC_844 0330-0132 15.3 µM -0.0846709793280888 0.45759956637964 no 1830 0.466261484116797 586 2828079
SGTC_587 k089-0003 57 µM -0.0847401762991428 0.457571415699073 no 1831 0.466233977377502 586 9659696
SGTC_1718 roemerine 11.9335 µM -0.0851927576987936 0.457387301993515 no 1832 0.466054074084798 582 235224 An aporphine alkaloid with mutagenic activity.
SGTC_312 4092-0653 6.84 µM -0.0864307933798615 0.456883706091918 no 1833 0.46556198446825 593 1148278
SGTC_2938 9059746 27.26 µM -0.0864547972372607 0.45687394272197 no 1834 0.465552444026105 611 6471769
SGTC_189 3970-0742 2.116 µM -0.0867191377201634 0.456766426145712 no 1835 0.465447382011344 584 2891807
SGTC_2250 alverine citrate 130 µM -0.0878922886116491 0.456289302694547 no 1836 0.464981142840911 583 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_2261 9010538 184.68 µM -0.0893519805789524 0.455695730321778 no 1837 0.464401092352645 660 6457250
SGTC_2395 5646831 180.19 µM -0.0898061917290109 0.455511049002968 no 1838 0.464220613893617 595 6808628
SGTC_279 1273-0055 2.93 µM -0.0910128803332038 0.455020458700336 no 1839 0.463741178254284 589 2847562
SGTC_934 2950-0684 338 µM -0.0919539639000734 0.454637900126415 no 1840 0.46336730802225 611 1121253
SGTC_2957 9076800 11.52 µM -0.0930281029672707 0.454201304779568 no 1841 0.462940617543835 601 16459615
SGTC_490 phenamil 164 µM -0.0935768082334966 0.453978298956625 no 1842 0.462722666553637 589 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_1529 apigenin 74 µM -0.0941479343177469 0.453746196233433 no 1843 0.462495821686475 615 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_545 4218-0007 221 µM -0.0944589049290417 0.453619826002646 no 1844 0.462372312775687 598 2840508
SGTC_2190 6049624 200 µM -0.0944951908264063 0.45360508067947 no 1845 0.462357901258755 588 2265554
SGTC_150 3970-0969 77.2 µM -0.0948849913229639 0.45344668339043 no 1846 0.462203088958842 589 6615640
SGTC_2007 4011539 71.82 µM -0.094941360116758 0.453423778274805 no 1847 0.462180702127151 577 45595301
SGTC_1615 st002656 86.5 µM -0.0952077400136014 0.453315538525531 no 1848 0.462074911137444 581 1584458
SGTC_1996 st072960 66.8 µM -0.0956292185496763 0.453144283699304 no 1849 0.461907529247179 593 1719405
SGTC_1581 himbacine 57.9 µM -0.0958630897230229 0.453049261105778 no 1850 0.461814654830341 623 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_627 1391-0720 175 µM -0.0958900445689729 0.453038309439743 no 1851 0.461803950713676 604 997839
SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.0960581091427105 0.45297002615734 no 1852 0.461737210730119 600 5377381
SGTC_2804 7954240 19.48 µM -0.0972356783292552 0.452491628402915 no 1853 0.461269617533537 601 828705
SGTC_358 0075-0058 9.45 µM -0.0978039189571691 0.452260800315427 no 1854 0.461043997714161 647 1069125
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.0979510475296067 0.452201037051749 no 1855 0.460985582386697 591 688788
SGTC_800 3448-7362 155 µM -0.0980976824492526 0.452141475386187 no 1856 0.460927363894728 595 15991913
SGTC_233 rapamycin 362 pM -0.098184169639591 0.452106345642997 no 1857 0.46089302626051 585 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_669 0108-0021 26.2 µM -0.0982990799064865 0.452059671471039 no 1858 0.460847404386544 658 17201
SGTC_2717 st081029 62.2815 µM -0.0990675411800517 0.451747555469962 no 1859 0.460542321830965 599 5292846
SGTC_1821 st053465 65.6 µM -0.0996233850125836 0.451521814127932 no 1860 0.46032166381331 611 675086
SGTC_2644 guaiazulene 100 µM -0.10225297967279 0.450454087177905 no 1861 0.459277938196254 591 3515 A coloring agent.
SGTC_2457 5731572 11.68 µM -0.103289473828918 0.450033324664557 no 1862 0.458866614801452 602 2865357
SGTC_605 1315-0399 119 µM -0.103952302693854 0.449764280162515 no 1863 0.458603600176441 595 24020461
SGTC_1527 coumarin 137 µM -0.10396225609851 0.449760240217202 no 1864 0.458599650741254 639 323 A hepatotoxic, DNA x-linker.
SGTC_2013 4024628 200 µM -0.104029026264991 0.449733139291413 no 1865 0.458573156953235 603 5230760
SGTC_3014 9081533 49.47 µM -0.104276699848177 0.449632614656562 no 1866 0.458474883961375 609 21367265
SGTC_2789 5281112 71.43 µM -0.105097270845733 0.449299588136758 no 1867 0.45814931243096 592 765948
SGTC_3301 9125354 19.7965 µM -0.105154247622044 0.449276465589431 no 1868 0.458126707241417 591 41905162
SGTC_981 1488-1094 54.9 µM -0.105204820770284 0.449255941932816 no 1869 0.458106642765829 583 3449522
SGTC_3144 9087057 49.47 µM -0.105380446527226 0.449184670328935 no 1870 0.458036965538083 633 17249618
SGTC_2643 anethole 100 µM -0.105699519294646 0.449055189942703 no 1871 0.457910380881491 610 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_200 k038-0079 37.545 µM -0.106612004435697 0.448684931582029 no 1872 0.457548397352361 591 3436683
SGTC_593 1203-0218 61.7 µM -0.107119264297478 0.44847912046277 no 1873 0.457347182200175 603 3666956
SGTC_1471 k673-0312 37 µM -0.107296800277116 0.448407091861053 no 1874 0.457276761449406 586 24099884
SGTC_2110 5483698 200 µM -0.107871498801189 0.448173941046426 no 1875 0.45704881291529 588 2848765 YHR062C RPP1
SGTC_251 melphalan 456.522 µM -0.107963370484869 0.448136671061515 no 1876 0.457012374220963 612 460612 A DNA alkylator.
SGTC_2359 9039622 200 µM -0.108695728409193 0.447839588638895 no 1877 0.456721915008689 592 6463596
SGTC_2106 5357045 167.29 µM -0.109996894493969 0.447311840342874 no 1878 0.456205918902727 603 668842
SGTC_1036 k216-0215 33.5 µM -0.110071500233636 0.447281583341018 no 1879 0.456176335154986 595 622330
SGTC_1195 1502-0147 41.1 µM -0.111204441359223 0.446822147093018 no 1880 0.455727114892376 605 817940
SGTC_1714 st033236 13.627 µM -0.114269482067512 0.445579555072321 no 1881 0.454512086894525 635 2916566
SGTC_1282 0886-0010 32.4 µM -0.114285827654223 0.445572929862453 no 1882 0.454505608389935 609 2836211 YNL267W PIK1
SGTC_44 0929-0055 61.211 µM -0.114405384585842 0.445524471387324 no 1883 0.454458222870706 584 1379590
SGTC_2511 berberine 10.47 µM -0.114821519630143 0.445355811066774 no 1884 0.454293295834501 601 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1255 0566-0045 221 µM -0.115773446737366 0.444970030446068 no 1885 0.453916047705319 624 2788469
SGTC_788 1182-0090 188 µM -0.115969536031137 0.444890569215988 no 1886 0.453838342791219 594 5715185
SGTC_1924 st058459 75.1 µM -0.11609385018257 0.44484019456098 no 1887 0.453789081350953 619 688683
SGTC_1008 4106-0037 6 µM -0.118050011455178 0.444047635532234 no 1888 0.453014015737374 599 2905394
SGTC_2484 5809818 12.04 µM -0.118356037321934 0.443923666134393 no 1889 0.452892779003107 609 2870548
SGTC_2436 5633522 8.09 µM -0.118481373110778 0.443872894877817 no 1890 0.452843126618502 619 5724242
SGTC_810 3825-7150 143 µM -0.11865518594024 0.443802487975352 no 1891 0.452774271038023 594 22330411 YGL099W LSG1
SGTC_229 benomyl 22.8748 µM -0.119509303162675 0.44345653387607 no 1892 0.452435935001155 607 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_883 0850-0245 24.6 µM -0.1199522224246 0.443277149533575 no 1893 0.45226049778584 593 6823229 YPR165W RHO1
SGTC_3162 9099653 49.47 µM -0.12021697200944 0.443169930279968 no 1894 0.452155636779401 594 25237511
SGTC_1650 st011916 45.8 µM -0.120770392118365 0.442945817632476 no 1895 0.451936451040268 596 242528
SGTC_3172 9105863 49.47 µM -0.121696940729563 0.442570644005589 no 1896 0.451569518087072 601 2348785
SGTC_1303 1160-0052 261 µM -0.122256981429118 0.442343899955148 no 1897 0.451347750101957 600 3562476
SGTC_1843 st055809 45.5 µM -0.122416699189747 0.442279238377138 no 1898 0.451284506967474 597 16413835
SGTC_285 1486-1325 46 µM -0.123236387446976 0.441947412628206 no 1899 0.450959956076344 602 22310230
SGTC_1779 st039427 55 µM -0.12324810775496 0.441942668314405 no 1900 0.450955315724448 595 1124498
SGTC_1899 st063254 59.6 µM -0.123251815697873 0.441941167362004 no 1901 0.450953847662038 598 3093813
SGTC_1364 1653-0028 37.6 µM -0.123631660090883 0.441787413117014 no 1902 0.450803461829832 587 5718652
SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.124011839410491 0.441633532081983 no 1903 0.450652950466813 603 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_834 0312-0008 75.7 µM -0.124082241871372 0.441605037012057 no 1904 0.450625079212378 609 6385573 YIL048W NEO1
SGTC_2141 5621638 7.665 µM -0.127372399314665 0.440273700597565 no 1905 0.449322830222403 620 2856238
SGTC_1124 fisetin 1.16336 µM -0.127929230329565 0.440048449662813 no 1906 0.449102489321116 634 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_1932 st074806 40.9 µM -0.129392290177073 0.439456701001135 no 1907 0.44852362397306 600 17251235
SGTC_16 erodoxin 22.806 µM -0.130140651934793 0.439154071074715 no 1908 0.448227573999483 615 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_1238 0333-0287 48.8 µM -0.131178043968946 0.438734619078586 no 1909 0.447817232116428 605 7226
SGTC_191 3914-0123 66.505 µM -0.134062702705647 0.437568618976553 no 1910 0.446676496138712 633 3144412
SGTC_2253 7938677 135.83 µM -0.13472092046339 0.437302638132282 no 1911 0.446416265922826 618 2301972
SGTC_1211 1056-0033 32.3 µM -0.134786818466529 0.437276010803277 no 1912 0.44639021403321 612 6741922
SGTC_2150 5556613 200 µM -0.136329373587838 0.436652793775674 no 1913 0.445780451945489 604 743190
SGTC_678 1218-2179 85.9 µM -0.136561890428103 0.436558866836006 no 1914 0.445688550623624 598 6820081 YOR116C RPO31
SGTC_3356 9151811 4.48 µM -0.136917390265974 0.436415266899148 no 1915 0.445548046422412 595 1859254 YPR165W RHO1
SGTC_701 4424-0219 185 µM -0.137657531210197 0.43611632266234 no 1916 0.445255542477286 629 2911779
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.138314666577295 0.435850935101358 no 1917 0.444995867333491 609 91467 include heat shock
SGTC_870 0573-2213 57.6 µM -0.138702653728924 0.435694258010378 no 1918 0.444842560499989 592 3916321
SGTC_3225 9130819 49.47 µM -0.139944284157507 0.435192930375969 no 1919 0.444352005920495 636 4547121
SGTC_2593 nobiletin 86.24 µM -0.140824275904821 0.434837683013759 no 1920 0.444004382387836 608 72344 An anti-infammatory.
SGTC_3249 9135183 49.47 µM -0.14152291950316 0.434555682247438 no 1921 0.443728427557781 616 4902779
SGTC_1980 st071811 45.7 µM -0.142444916600574 0.43418357797384 no 1922 0.443364292880765 641 4974850
SGTC_1026 k007-1105 30.6 µM -0.142875087423211 0.434009987376042 no 1923 0.44319441702452 587 7066794
SGTC_893 0958-0369 48.9 µM -0.143484249626235 0.433764188596775 no 1924 0.442953874758021 627 6819948
SGTC_1939 st074455 53.6 µM -0.144272222881578 0.433446277026193 no 1925 0.442642755869483 598 1644229
SGTC_3185 9108267 49.47 µM -0.144804042406706 0.433231736224444 no 1926 0.442432795244581 625 4910486
SGTC_1058 3448-5425 97.3 µM -0.14511083489873 0.433107982305825 no 1927 0.442311681913136 605 7279705
SGTC_2734 clemastine 41.6 µM -0.146696156130003 0.432468600403131 no 1928 0.441685926372507 622 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_2844 9010103 25.97 µM -0.14671247694463 0.432462018910225 no 1929 0.441679484999916 664 2480525
SGTC_3096 9117468 49.47 µM -0.146923121978973 0.432377076376781 no 1930 0.441596350635522 626 41316311
SGTC_1017 4239-0030 168 µM -0.147227805240679 0.432254218493116 no 1931 0.441476107163859 596 1149593
SGTC_299 1273-0059 1.44 µM -0.14809337735947 0.431905228340237 no 1932 0.441134537958893 618 2848077
SGTC_1040 k898-0338 155 µM -0.14822373742413 0.431852673043283 no 1933 0.441083099488846 599 20969351
SGTC_2610 ononetin 44.17 µM -0.148894819544673 0.43158214211338 no 1934 0.440818314526527 636 259632
SGTC_69 0096-0274 206.684 µM -0.149309798783904 0.431414869067776 no 1935 0.44065459181663 630 6741392
SGTC_2917 7979103 53.79 µM -0.149685871889967 0.431263289230234 no 1936 0.440506227593868 649 2980565
SGTC_661 1304-0007 33.6 µM -0.14987908526877 0.431185416677629 no 1937 0.440430006424474 609 3117130
SGTC_1467 k284-1082 293 µM -0.151130437186681 0.430681137779517 no 1938 0.439936411425086 635 3334705
SGTC_364 0083-0097 67.7 µM -0.151255493037123 0.430630748061016 no 1939 0.43988708833891 631 5207356
SGTC_1657 st012939 43.4 µM -0.15262574694602 0.430078695244798 no 1940 0.439346709876182 615 24207257
SGTC_1224 0823-0416 294 µM -0.152816968973133 0.430001665869539 no 1941 0.439271307803992 636 3598164
SGTC_1245 0418-0076 17.2 µM -0.153011397946097 0.429923347381856 no 1942 0.439194643438053 651 6790114
SGTC_1814 st052110 31.539 µM -0.15310808534024 0.429884401483924 no 1943 0.439156519939282 645 674163
SGTC_1801 st050089 28.441 µM -0.154228266674492 0.429433239780262 no 1944 0.438714877621645 618 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_732 3970-1727 52.7 µM -0.155528786851157 0.428909560850489 no 1945 0.438202230714359 620 1275699
SGTC_2181 6316240 54.2555 µM -0.156220642189269 0.428631023201228 no 1946 0.43792955318965 622 12779990
SGTC_729 4092-0585 94.1 µM -0.157355478409583 0.42817422059705 no 1947 0.43748234967245 611 2169061
SGTC_1902 st060212 70.5 µM -0.157610976483141 0.428071388887489 no 1948 0.437381676852677 611 688944
SGTC_1087 pterostilbene 9.05 µM -0.157909815825607 0.427951119578168 no 1949 0.437263931601228 621 5281727 Similar to reservatol, lowers cholesterol.
SGTC_59 0330-0160 1.33 µM -0.158469966919405 0.427725702156092 no 1950 0.437043242265722 614 4293482
SGTC_1262 0737-0114 49.6 µM -0.159341367341146 0.427375077907533 no 1951 0.436699965325221 619 765919
SGTC_1618 st003135 44.5 µM -0.159791853779868 0.42719383874082 no 1952 0.436522520683823 616 1270615
SGTC_412 gemfibrozil 100 µM -0.160151067044472 0.427049331498289 no 1953 0.43638103729858 601 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_709 3807-1509 243 µM -0.160835691004432 0.42677394251019 no 1954 0.436111406904767 631 1886677 YPL242C IQG1
SGTC_262 fenpropimorph 62.5 µM -0.161664143311864 0.426440746515611 no 1955 0.435785171265107 612 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_3001 9076041 71.4286 µM -0.161931666961708 0.426333162134299 no 1956 0.435679832640644 629 16004211
SGTC_1914 st062367 72.6 µM -0.162221256343571 0.426216710218546 no 1957 0.435565810679816 634 978205
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.163468994679227 0.425715033752901 no 1958 0.435074591709617 611 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_481 bay k-8644 50 µM -0.164462800696185 0.425315541482398 no 1959 0.434683414353796 665 2303 A calcium channel antagonist.
SGTC_142 0335-0849 62.6745 µM -0.166443686257748 0.424519489961829 no 1960 0.433903898367331 606 3889043 YPR107C YTH1
SGTC_1200 1643-0193 18.4 µM -0.166646271655982 0.424438094973068 no 1961 0.433824191609947 642 5403974
SGTC_795 0685-0265 78 µM -0.166871421869657 0.424347637648243 no 1962 0.433735609935279 620 302754
SGTC_2328 6201408 200 µM -0.16719585390469 0.424217299437989 no 1963 0.433607973303394 647 2890418
SGTC_2303 7774051 200 µM -0.168378939738888 0.423742073629356 no 1964 0.433142587604121 634 2953184
SGTC_1531 st059297 52.4 µM -0.169017966547366 0.423485433317445 no 1965 0.432891254724651 622 7566702
SGTC_822 1487-0950 154 µM -0.169241160746957 0.423395803673356 no 1966 0.432803477567049 628 1958375
SGTC_2451 5856223 45.7 µM -0.171104944823914 0.422647506147909 no 1967 0.43207062390292 600 2179896
SGTC_2365 9042475 200 µM -0.171816804871455 0.422361772336233 no 1968 0.4317907768092 621 6464479
SGTC_1747 st037496 66.6 µM -0.172399327339702 0.422127983777603 no 1969 0.431561800483575 611 723305
SGTC_1717 st033143 58.0435 µM -0.172451535585482 0.422107031949131 no 1970 0.43154127973193 642 674616
SGTC_2483 5729050 27.16 µM -0.172685120903359 0.422013293910959 no 1971 0.431449469940898 646 2865180
SGTC_149 3970-0822 46.1 µM -0.174265951731579 0.421379021189795 no 1972 0.430828228181102 625 3114250 YBL034C STU1
SGTC_478 N-arachidonylglycine 10 µM -0.175274478605586 0.420974478983695 no 1973 0.430431982226395 611 5283389
SGTC_3124 9127567 49.47 µM -0.176529808988699 0.420471055079351 no 1974 0.42993886610263 651 17592030
SGTC_2286 7945697 125 µM -0.176951495607272 0.420301975651863 no 1975 0.429773244570461 637 1245733
SGTC_3277 9138724 49.47 µM -0.177313380315384 0.420156886116732 no 1976 0.429631120674147 628 15943418
SGTC_2513 baicalein 25.65 µM -0.177500631044787 0.420081816406013 no 1977 0.429557584800771 659 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_2767 sibutramine 71.45 µM -0.178190845522749 0.419805131259435 no 1978 0.429286549443724 669 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_2077 5212015 200 µM -0.178594001254774 0.419643537210409 no 1979 0.429128252533059 616 780900
SGTC_169 k015-0017 16.025 µM -0.179046401138602 0.41946222111183 no 1980 0.428950633744959 669 1840002
SGTC_425 3825-7017 13.1 µM -0.179676209344667 0.419209830501933 no 1981 0.428703385826892 621 3397440
SGTC_2199 6590217 200 µM -0.179716801015935 0.4191935648529 no 1982 0.428687451448246 635 703109
SGTC_646 4092-0839 27.3 µM -0.183270676326906 0.417770015794369 no 1983 0.427292820796743 635 877796
SGTC_1122 capsaicin 818.572 nM -0.184779148416612 0.417166102945388 no 1984 0.426701131685263 640 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.184806787144777 0.417155039671346 no 1985 0.42669029209464 623 5106787 A p450 inhibitor.
SGTC_2930 9013230 14.89 µM -0.18499848942926 0.417078306581971 no 1986 0.426615110192464 636 2995857
SGTC_2634 4'-methoxyflavone 100 µM -0.185033037040381 0.417064478470515 no 1987 0.426601561575737 641 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_2697 mebhydrolin 72.4 µM -0.186221408212349 0.416588880688323 no 1988 0.426135568133054 634 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_2889 9059656 51.95 µM -0.186235921761121 0.416583072977101 no 1989 0.426129877602311 640 3949838
SGTC_1395 3486-0190 4.35 µM -0.186238657626139 0.416581978201137 no 1990 0.426128804915043 657 6748079
SGTC_479 n-linoleoylglycine 10 µM -0.186754917566966 0.416375404681496 no 1991 0.425926397751433 646 6433346 An anti-infammatory.
SGTC_2185 6113692 200 µM -0.187294318170081 0.416159596451565 no 1992 0.425714938803492 631 874150
SGTC_3239 9133757 49.47 µM -0.187410071543393 0.416113288095807 no 1993 0.425669563277736 651 17036923
SGTC_3168 9103419 49.47 µM -0.187868059320536 0.415930076688689 no 1994 0.4254900409219 630 16649256
SGTC_325 2810-4341 181 µM -0.188312285702909 0.415752387782982 no 1995 0.425315927522945 627 774970
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.189086792948611 0.415442628969186 no 1996 0.425012396233741 669 5393153
SGTC_2312 7706453 155.7 µM -0.189729512326801 0.415185617684578 no 1997 0.424760546672712 650 976098
SGTC_2271 7849410 118.62 µM -0.190237011106316 0.414982704186118 no 1998 0.424561704990246 619 972430
SGTC_3271 9137798 49.47 µM -0.190547436301344 0.414858597895329 no 1999 0.424440087618623 623 6498326
SGTC_237 nikkomycin 200 µM -0.190584504236491 0.414843778905765 no 2000 0.424425565744304 656 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_686 1319-0111 510 µM -0.190672859331926 0.414808456864833 no 2001 0.424390951832044 667 4562600
SGTC_3121 9125696 49.47 µM -0.190882578527996 0.41472461940983 no 2002 0.424308794764714 635 1235365
SGTC_334 1502-1024 68.5 µM -0.194974475138166 0.413089622454786 no 2003 0.422706465007666 663 3296216
SGTC_1852 st056254 31.4 µM -0.196341654682643 0.412543673558242 no 2004 0.422171380055822 634 442583
SGTC_1822 st052468 42 µM -0.197089290278588 0.412245195490259 no 2005 0.421878832088544 633 2873678
SGTC_2379 9035213 200 µM -0.197395128511523 0.412123110510248 no 2006 0.421759170755269 620 646551
SGTC_3199 9111318 49.47 µM -0.197923704948843 0.411912132604038 no 2007 0.42155237858953 642 8548020
SGTC_953 1188-0045 9.7 µM -0.198018655661435 0.411874236329856 no 2008 0.421515233814559 644 6144426
SGTC_4 0960-0234 25.671 µM -0.198396428405647 0.411723469622817 no 2009 0.421367455813433 621 6821112
SGTC_1809 st050081 57.6 µM -0.198684038059539 0.411608695169733 no 2010 0.421254955439696 632 5036894
SGTC_2775 cyproheptadine 69.59 µM -0.198692090488373 0.411605481849828 no 2011 0.421251805772618 633 2913 A selective serotonin reuptake inhibitor.
SGTC_2743 auranofin 4.32 µM -0.198918164143311 0.411515269629469 no 2012 0.421163380255921 616 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_2663 amphotericin b 100 µM -0.199424448599734 0.411313259326569 no 2013 0.420965368672706 652 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2898 9056270 58.44 µM -0.200017078143326 0.411076826726852 no 2014 0.420733612289128 629 19154699
SGTC_2768 sulfasalazine 50.2 µM -0.20005474636533 0.411061799887041 no 2015 0.420718882511925 695 5384001 An antioxidant and salicylic acid derivative.
SGTC_2744 captopril 92.04 µM -0.201876726741633 0.410335120438672 no 2016 0.420006548422716 628 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_3351 9150312 21.596 µM -0.202019862426301 0.410278045145728 no 2017 0.419950598171019 617 4904905
SGTC_2972 9093619 59.92 µM -0.202326896670338 0.410155621784303 no 2018 0.419830587134351 627 25236256
SGTC_2723 salbutamol 83.58 µM -0.20273866305641 0.40999145246045 no 2019 0.419669650958839 652 9884233 β2-adrenoceptor agonist
SGTC_3313 9133968 57.047 µM -0.20280143941924 0.409966425204676 no 2020 0.419645116411142 642 1494643
SGTC_1520 flindersine 88 µM -0.203411038833694 0.409723413321114 no 2021 0.419406886213406 658 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_1908 st060353 56.5 µM -0.204964076628433 0.409104464255157 no 2022 0.418800095920248 669 4227716
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.205048325304896 0.409070894177328 no 2023 0.418767184472445 617 688803
SGTC_2235 salicylic acid 500 µM -0.205417661553401 0.408923734794059 no 2024 0.418622911284293 627 338 A COX inhibitor and kinase inhibitor.
SGTC_2391 6285546 200 µM -0.205965500217067 0.4087054760505 no 2025 0.418408930166647 625 846083
SGTC_592 k241-0073 46.5 µM -0.206239133714394 0.408596471152284 no 2026 0.418302060289681 650 4230158
SGTC_670 4204-0025 119 µM -0.2079766054622 0.407904495591367 no 2027 0.417623617044266 655 719039
SGTC_2735 sertaconazole 140 nM -0.208017402568634 0.407888250941813 no 2028 0.417607689638668 623 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_1784 st039334 36.3 µM -0.209646010898432 0.407239898988998 no 2029 0.416971983020992 635 3496984
SGTC_2576 guaiol 23.12 µM -0.209655248041326 0.407236222388462 no 2030 0.416968378036745 637 227829
SGTC_1392 3455-1037 33.9 µM -0.209822419357772 0.40716968567797 no 2031 0.416903137212607 632 981132
SGTC_440 fluspirilene 35.1 µM -0.210923125649826 0.406731654908 no 2032 0.416473629197271 659 3396 An atypical antipsychotic.
SGTC_3329 9141233 27.5565 µM -0.211048375648702 0.406681818518673 no 2033 0.416424761543346 652 4909101 YNL103W MET4
SGTC_121 0557-0495 61.343 µM -0.211858742018183 0.406359414081875 no 2034 0.416108619508397 647 3104427
SGTC_1811 st050069 61.5 µM -0.212204743683916 0.406221776568014 no 2035 0.415973653045937 641 3877702
SGTC_2843 9000894 45.46 µM -0.212901763782963 0.405944541100093 no 2036 0.415701793311387 618 2242070
SGTC_1039 k821-0043 94 µM -0.212999412665923 0.405905705619153 no 2037 0.415663710398232 644 15992768
SGTC_2597 laccaic acid a 100 µM -0.213653385879928 0.405645640872267 no 2038 0.415408682290135 659 5491415 A textile dye.
SGTC_2904 7225135 42.03 µM -0.215595769147445 0.404873461577994 no 2039 0.414651426990287 648 4446116
SGTC_2586 curcumin 80 µM -0.215916882211034 0.404745841173347 no 2040 0.414526268688447 655 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_3226 9131256 49.47 µM -0.217359453019763 0.404172643463358 no 2041 0.413964113796141 625 17178073
SGTC_516 3992-2719 87.3 µM -0.218279959727048 0.403806992509905 no 2042 0.413605493912308 638 5350887 YDR037W KRS1
SGTC_3348 9149464 3.537 µM -0.21913975694855 0.403465532965001 no 2043 0.413270590888451 635 1951442
SGTC_3321 9137793 26.8275 µM -0.219444294555328 0.403344606646484 no 2044 0.413151984357779 634 4904192
SGTC_809 3998-0021 90 µM -0.219933254765757 0.403150468817291 no 2045 0.41296156838769 654 715485
SGTC_927 2425-1185 123 µM -0.222300820116294 0.40221078392968 no 2046 0.412039856857706 653 730375
SGTC_2327 6189656 200 µM -0.22286870262643 0.40198547558376 no 2047 0.411818847727238 688 5349088
SGTC_2572 astragaloside iv 100 µM -0.223228008935231 0.401842937015395 no 2048 0.411679026951424 640 45006101 An anti-inflammatory agent.
SGTC_1019 4262-0212 3.4 µM -0.223304483727009 0.401812600776306 no 2049 0.411649268929937 643 4677213
SGTC_432 NS 1619 61.3 µM -0.223843175669219 0.401598927687259 no 2050 0.411439666467975 635 4552 A K+/calcium channel activator.
SGTC_2943 9068529 45.32 µM -0.224371753609821 0.40138929492672 no 2051 0.411234023880955 634 3270634
SGTC_1393 3470-5649 58.2 µM -0.226460603706485 0.400561140152837 no 2052 0.410421598502575 657 4108395
SGTC_368 fentichlor 4.58 µM -0.226722601982709 0.400457298613254 no 2053 0.410319725444322 678 7329 A pesticide.
SGTC_2526 patulin 37.61 µM -0.227719558542539 0.400062224882738 no 2054 0.409932133182301 647 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_1223 0764-0573 147 µM -0.228519547458261 0.399745279377928 no 2055 0.409621180719268 644 1609797
SGTC_2811 7967822 32.47 µM -0.228549570962588 0.399733385729249 no 2056 0.409609511809772 636 2232244
SGTC_1433 4060-0023 7.6 µM -0.230180582123624 0.399087409571569 no 2057 0.408975724998366 629 3840627
SGTC_345 1362-0200 395 µM -0.230404984908493 0.398998554476329 no 2058 0.408888543976717 664 1419823
SGTC_308 4092-1169 104 µM -0.231316744596068 0.398637585676787 no 2059 0.408534369551122 647 2268590 YDL196W YDL196W
SGTC_862 0452-0056 10.2 µM -0.232610319572076 0.398125603708408 no 2060 0.408032006622262 635 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_163 TUB2.036 7.546 µM -0.234479685781147 0.397386040254129 no 2061 0.407306301023117 627 15992207 YJR013W GPI14
SGTC_903 1134-0042 114 µM -0.234848325657891 0.397240241445041 no 2062 0.407163229010624 641 701009
SGTC_403 arphamenine a 50 µM -0.235160733895019 0.397116693753538 no 2063 0.407041990631456 661 5487158 An arginine aminopeptidase inhibitor.
SGTC_1968 st069590 43.6 µM -0.235547397142268 0.396963794824 no 2064 0.406891947942762 654 6384066
SGTC_816 0325-0417 81.3 µM -0.235969264963321 0.396796992953802 no 2065 0.406728259888366 653 68101
SGTC_2198 6589944 200 µM -0.236022352752811 0.39677600396592 no 2066 0.406707662559421 655 5290268
SGTC_2144 5628481 200 µM -0.236438189453898 0.396611607555684 no 2067 0.406546332596438 632 2818399
SGTC_1804 st050076 49.1 µM -0.238805907923104 0.395675907446179 no 2068 0.40562804444977 637 3895976
SGTC_2648 atorvastatin 78.68 µM -0.238817129474064 0.395671474221234 no 2069 0.405623693552389 666 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_821 1114-0266 29.2 µM -0.23886781407809 0.395651450753484 no 2070 0.4056040419123 659 3123235
SGTC_897 1000-0139 31.4 µM -0.241128661906098 0.394758560735541 no 2071 0.404727699535197 673 6151020
SGTC_577 r071-0003 38.6 µM -0.242459144641849 0.394233363247357 no 2072 0.404212205173377 640 4568517 YMR134W ERG29
SGTC_2249 haloperidol 116.36 µM -0.243172548190817 0.393951831979931 no 2073 0.4039358660203 669 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_382 3229-0966 23.2 µM -0.243172913280593 0.393951687918304 no 2074 0.403935724613864 685 5722370
SGTC_2788 5282734 71.43 µM -0.243711863953804 0.393739037946372 no 2075 0.40372699213879 692 743706
SGTC_2440 5628896 157.78 µM -0.244080419331639 0.393593637884089 no 2076 0.403584268555319 649 5522048
SGTC_448 monastrol 171 µM -0.244273622212486 0.393517422670266 no 2077 0.4035094555985 658 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_3028 9087778 49.47 µM -0.244462744242797 0.393442821233103 no 2078 0.403436226267998 618 17217395
SGTC_2331 7980721 200 µM -0.244851387031987 0.393289528738195 no 2079 0.403285751778772 652 2981221
SGTC_119 0121-0043 24.815 µM -0.245725642105708 0.39294475653317 no 2080 0.402947310572381 675 1092378
SGTC_3057 9095946 49.47 µM -0.245959559475274 0.392852522846058 no 2081 0.402856768909875 642 24540043
SGTC_104 0074-0074 590.992 µM -0.248148149869746 0.391989853127923 no 2082 0.402009891088203 672 3943124
SGTC_928 2764-0428 58.7 µM -0.248241023607704 0.391953257090198 no 2083 0.401973963621063 670 662578
SGTC_761 k216-0224 480 µM -0.248300742751846 0.391929725818521 no 2084 0.40195086218247 729 1340404
SGTC_1134 3477-0009 42.5 µM -0.249360748881018 0.391512115021182 no 2085 0.401540872078736 646 3973534
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.249950487742962 0.39127982958785 no 2086 0.401312819246744 691 6708760
SGTC_1663 st014140 55.4 µM -0.25054654473634 0.391045094973345 no 2087 0.401082357340749 662 4207120
SGTC_2037 5169046 200 µM -0.251414460297545 0.390703370078649 no 2088 0.400746844489222 659 5718022
SGTC_2470 5664817 21.68 µM -0.252309691053617 0.390350978776287 no 2089 0.400400849014548 650 2859561
SGTC_1316 1272-0050 65.9 µM -0.252718621475802 0.390190040702954 no 2090 0.400242828512346 673 7340392
SGTC_1641 st009299 47.1 µM -0.25359737463545 0.389844263564553 no 2091 0.399903312541066 652 4046054
SGTC_1850 st056238 17 µM -0.25504562983329 0.389274585606243 no 2092 0.399343928377425 666 5393177
SGTC_999 SEC7.066 22.7 µM -0.256466662355284 0.388715847029352 no 2093 0.398795259676853 649 740511 YDR170C SEC7
SGTC_1074 carmofur 3.8 µM -0.256830501852829 0.388572825219699 no 2094 0.398654811293377 665 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2945 9067681 61.76 µM -0.258196014156049 0.388036190324151 no 2095 0.398127816954586 687 16456930
SGTC_921 1561-0023 372 µM -0.258215621513129 0.388028486351165 no 2096 0.398120251206715 657 24050882
SGTC_3150 9097574 49.47 µM -0.258753879635087 0.387817015300166 no 2097 0.397912572439382 701 17217476
SGTC_1669 st015249 58.4 µM -0.259308311058822 0.387599224859514 no 2098 0.397698683687773 665 722793
SGTC_1144 3486-0183 12.5 µM -0.260082751446571 0.387295070226954 no 2099 0.397399971284895 696 6744069
SGTC_3148 9097893 49.47 µM -0.26015071442889 0.387268381663956 no 2100 0.39737375988862 656 17174100
SGTC_3058 9093861 49.47 µM -0.260776435468788 0.387022690667383 no 2101 0.397132458805028 695 17217477
SGTC_898 1000-0849 28.3 µM -0.261200286832176 0.386856290031473 no 2102 0.396969028466873 665 6751807
SGTC_2915 7971052 15.16 µM -0.262277274689722 0.386433566880883 no 2103 0.396553840549843 661 5741558
SGTC_846 0335-0850 148 µM -0.263353624467716 0.386011228797723 no 2104 0.396139015774918 665 6819598
SGTC_1140 3229-1848 2.98 µM -0.264024911088331 0.385747897728196 no 2105 0.395880361678363 687 2849525
SGTC_93 0109-0045 59.227 µM -0.264028831868553 0.385746359846333 no 2106 0.395878851093288 656 88733
SGTC_1278 0874-0585 172 µM -0.264646875568007 0.38550396163802 no 2107 0.395640752851866 656 766306
SGTC_492 tmb-8 126 µM -0.265302603490739 0.385246832476186 no 2108 0.39538817952883 665 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_2823 7987624 58.44 µM -0.265693299929469 0.385093653505361 no 2109 0.395237711930636 717 2239440
SGTC_1667 st014849 34.6 µM -0.267151653795102 0.384522040405138 no 2110 0.394676199166744 650 5348460
SGTC_3258 9138477 49.47 µM -0.267861793773449 0.384243786323007 no 2111 0.394402851735808 636 4970355
SGTC_2231 micatex 6.853 µM -0.268186945186201 0.384116402173327 no 2112 0.394277711638192 668 20737 An antifungal of unknown mechanism.
SGTC_1043 0916-0009 19.3 µM -0.269113443545521 0.383753497796761 no 2113 0.393921192741346 708 3101130
SGTC_43 0570-0105 72.5 µM -0.269197567544081 0.383720551926368 no 2114 0.393888826012518 669 1114046 YDL195W SEC31
SGTC_1325 1431-0015 227 µM -0.270226849033546 0.383317517784253 no 2115 0.393492869122012 660 1103340
SGTC_1748 st037455 53.6035 µM -0.270334602905036 0.38327533206206 no 2116 0.393451423374233 683 580690
SGTC_604 1000-0114 314 µM -0.270994883105993 0.3830168621057 no 2117 0.393197483876629 688 1572745
SGTC_1861 st057647 17.4 µM -0.272711202170573 0.38234524438674 no 2118 0.392537611457117 688 688668
SGTC_2259 7964009 200 µM -0.273488658925157 0.382041131864834 no 2119 0.39223880451723 666 313134
SGTC_2036 5160441 105 µM -0.274102646849731 0.381801013758515 no 2120 0.392002869908818 663 134534 YIL048W NEO1
SGTC_1920 st075728 45.7 µM -0.275478521058387 0.381263102761548 no 2121 0.391474312694414 687 3400306
SGTC_930 2810-3379 265 µM -0.276917119691306 0.380700914289392 no 2122 0.390921873420271 713 1015764
SGTC_2671 danthron 100 µM -0.277764575540402 0.380369855674398 no 2123 0.390596543043883 667 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_2126 5251174 33.877 µM -0.277816124306362 0.380349720973864 no 2124 0.390576756422949 685 790722
SGTC_578 3460-0051 92 µM -0.278147873858831 0.380220148950003 no 2125 0.390449423538983 706 2876744
SGTC_1910 st062352 60.4 µM -0.280545059422555 0.379284276126768 no 2126 0.389529680184824 652 2245730
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.280602773913211 0.379261752804835 no 2127 0.389507544104189 690 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_508 roscovitine 141 µM -0.280776784393862 0.379193846966113 no 2128 0.389440805495886 670 160355 A CDKinase inhibitor.
SGTC_2975 9084847 53.72 µM -0.281537202903955 0.378897145056657 no 2129 0.389149198856129 653 27211724
SGTC_1681 tripelennamine 100 µM -0.285440529662966 0.377375262280434 no 2130 0.387653330140176 630 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_1249 0481-0015 10.2 µM -0.286092598497455 0.37712120950853 no 2131 0.387403600144563 669 4227577
SGTC_1830 st055982 50.3 µM -0.286717791748111 0.376877677677745 no 2132 0.387164206729453 700 455313 An antimicrobial agent.
SGTC_957 1187-1561 14.1 µM -0.287043054160079 0.376750997414934 no 2133 0.387039677115313 686 1538454
SGTC_2217 6934799 96.0675 µM -0.288922900698015 0.37601911213434 no 2134 0.386320189252077 683 675606
SGTC_2332 7982454 138.89 µM -0.289950637839189 0.375619168976824 no 2135 0.385927000682012 705 2981748
SGTC_832 4083-0019 164 µM -0.291187072839254 0.37513818829512 no 2136 0.385454124398828 665 1990758
SGTC_698 k064-0052 127 µM -0.293241125652531 0.374339578696118 no 2137 0.384668925650224 683 5088751
SGTC_1084 voriconazole 435 nM -0.293385410987357 0.374283501204676 no 2138 0.384613787714926 683 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1061 3448-9325 110 µM -0.293592612017074 0.374202975746472 no 2139 0.384534610937201 703 723482
SGTC_1942 st076330 65.2 µM -0.293603805232856 0.374198625833429 no 2140 0.384530333862163 715 24208414
SGTC_3231 9132313 49.47 µM -0.293668793066544 0.37417337054588 no 2141 0.384505501433487 689 4905967
SGTC_302 1094-0063 18.9 µM -0.294201524536439 0.373966363139065 no 2142 0.384301957879684 686 5440289
SGTC_2173 5763948 167 µM -0.295381990689907 0.373507790243306 no 2143 0.383851044612687 662 2867177
SGTC_2467 5474540 200 µM -0.297953785250103 0.372509352061501 no 2144 0.382869218218975 661 5413519
SGTC_2047 4141938 200 µM -0.298274548365665 0.37238488331271 no 2145 0.382746814062501 674 3807862
SGTC_1062 mesoridazine 14.2 µM -0.298376249515167 0.372345422035101 no 2146 0.382708007046679 672 4078 A neuroleptic.
SGTC_3263 9137018 49.47 µM -0.29963333003815 0.371857770357467 no 2147 0.3822284289554 675 43844957
SGTC_2710 st078562 53.7235 µM -0.300915164201428 0.371360727758456 no 2148 0.381739593293107 706 17250908
SGTC_1952 st077036 64.1 µM -0.301876903184624 0.370987945669406 no 2149 0.381372951718897 691 2937007
SGTC_3276 9139060 49.47 µM -0.303054107860464 0.370531811154677 no 2150 0.380924313546084 710 4870619
SGTC_2855 9016525 58.44 µM -0.303604895254953 0.370318458589173 no 2151 0.380714460827869 675 43811474
SGTC_1726 st035556 14.5795 µM -0.303932236306281 0.370191678914168 no 2152 0.380589758890379 693 5919439
SGTC_482 fipronil 114 µM -0.304700948649051 0.369894010945937 no 2153 0.380296963516277 661 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_310 1273-0058 1.06 µM -0.306898759526135 0.369043384587628 no 2154 0.379460216648261 677 2734232
SGTC_1829 berberine 14.4 µM -0.307372799222599 0.36885999925105 no 2155 0.379279814894187 704 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1125 tnp00248 1.32998 µM -0.307865661439638 0.368669363954711 no 2156 0.379092277864316 682 24207736
SGTC_2880 9042983 58.44 µM -0.308262367655408 0.368515944526534 no 2157 0.378941349436206 707 6464714
SGTC_1708 st033234 31.827 µM -0.309312090248808 0.368110083201915 no 2158 0.378542067465675 670 674664
SGTC_2450 5739737 12.93 µM -0.311620064233307 0.36721825370143 no 2159 0.377664641985053 670 2262825
SGTC_2033 5192550 145 µM -0.312793846963245 0.366764963945769 no 2160 0.377218645202277 659 182073
SGTC_2793 7325131 81.82 µM -0.312977972333491 0.366693875507324 no 2161 0.377148698779862 689 4176441
SGTC_495 decylubiquinone 155 µM -0.313049786847754 0.366666150085875 no 2162 0.377121418632731 710 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_2386 9075165 157.42 µM -0.313493445042558 0.366494882445933 no 2163 0.376952899997055 685 16452277
SGTC_61 0978-8327 98.565 µM -0.313518947361081 0.36648503846322 no 2164 0.376943213936753 714 6150059 YHR072W ERG7
SGTC_2851 9015922 71.43 µM -0.313796196222221 0.366378025118233 no 2165 0.376837916776959 690 2996893
SGTC_1509 1326-1131 80 µM -0.314307061152718 0.36618086715822 no 2166 0.37664391787954 657 768313
SGTC_1355 1499-0035 1.68 µM -0.315022525428022 0.365904807615093 no 2167 0.376372275573491 691 1548538
SGTC_1377 2944-0135 198 µM -0.315741406822908 0.36562749949717 no 2168 0.376099397537485 693 1894137
SGTC_110 0850-0284 111.64 µM -0.318191898104368 0.364682752145476 no 2169 0.37516968901641 661 3906265
SGTC_14 0354-0009 295 µM -0.319156827261628 0.364310964304145 no 2170 0.374803796564235 685 1713507
SGTC_2429 5902844 64.44 µM -0.320482687028553 0.363800317892705 no 2171 0.374301226294112 697 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_1694 st024011 44.9 µM -0.321140294849129 0.363547134098358 no 2172 0.37405203765896 725 2787533
SGTC_3153 9100258 49.47 µM -0.323162410550315 0.362768978581255 no 2173 0.373286123433561 713 25236848
SGTC_3269 9137823 49.47 µM -0.323459971646452 0.362654518120326 no 2174 0.373173458754024 664 17682936
SGTC_1764 st044502 93.5 µM -0.323463483838572 0.362653167186573 no 2175 0.373172129007819 678 8407
SGTC_96 0929-0093 37.281 µM -0.323758010602617 0.362539886146819 no 2176 0.373060624013246 681 6991579
SGTC_1495 4469-0029 237 µM -0.324624536175886 0.362206672433699 no 2177 0.372732627469837 699 793680
SGTC_3139 9095020 49.47 µM -0.324755001190939 0.362156512456986 no 2178 0.37268325194513 659 25236292
SGTC_426 0988-0037 14.6 µM -0.326731700902339 0.361396819389651 no 2179 0.371935410580227 722 5383008
SGTC_137 0438-0332 85.389 µM -0.327493116582195 0.361104334640598 no 2180 0.371647474181372 719 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_2878 9043973 25.97 µM -0.327776941615904 0.360995328894188 no 2181 0.371540161473313 682 6465167
SGTC_2097 5376186 200 µM -0.328079374991568 0.360879188857443 no 2182 0.371425824038328 674 742755
SGTC_1967 st070177 51.4 µM -0.328824007611981 0.360593290783637 no 2183 0.371144357897466 726 5729214
SGTC_3077 9117319 49.47 µM -0.32993558402077 0.360166651420232 no 2184 0.370724317718527 705 17154678
SGTC_2655 perillic acid 100 µM -0.330005187056226 0.360139942538833 no 2185 0.370698021387672 692 5702197 An apoptosis inducer.
SGTC_75 0159-0059 199.013 µM -0.330322284724508 0.360018270797341 no 2186 0.370578228149066 691 5377270
SGTC_3246 9135460 32.98 µM -0.330949610108792 0.359777605132335 no 2187 0.370341273978914 691 41446951
SGTC_706 4262-0057 46.9 µM -0.332041055723946 0.35935901799006 no 2188 0.369929128993535 684 883298
SGTC_3229 9132204 49.47 µM -0.333330354766173 0.358864768246226 no 2189 0.36944246424361 678 17682924
SGTC_850 0388-0143 75.9 µM -0.335090783662405 0.358190293546469 no 2190 0.3687783024737 683 67273
SGTC_2336 9001819 198.65 µM -0.336297255758344 0.35772831209352 no 2191 0.368323359566573 711 2989602
SGTC_1370 2001-0092 44.6 µM -0.337230748525385 0.357371002616423 no 2192 0.367971479762082 704 790957
SGTC_261 5-fluorouridine 15.376 µM -0.339088822406815 0.356660167048036 no 2193 0.36727140929189 680 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2652 actinonin 100 µM -0.339342274756574 0.356563243348603 no 2194 0.367175949636059 692 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_367 0335-0881 7.1 µM -0.340642680359255 0.356066095975653 no 2195 0.366686297379372 729 23828853
SGTC_1057 3448-5381 134 µM -0.340773613867647 0.356016053403087 no 2196 0.366637007928977 688 5497911
SGTC_392 N-ethylmaleimide 8.33 µM -0.342517365274468 0.355349831254536 no 2197 0.365980788920925 669 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_1378 2093-0007 380 nM -0.342871901962605 0.355214430036091 no 2198 0.365847415417405 713 3618014
SGTC_658 3253-0951 102 µM -0.344483887311315 0.354599026905407 no 2199 0.365241205722253 697 1184878
SGTC_833 3852-0053 558 µM -0.34478732626632 0.35448322624056 no 2200 0.365127130843239 718 3123681
SGTC_2334 9017922 200 µM -0.345461394172757 0.354226031494704 no 2201 0.364873764384223 685 3163164
SGTC_2229 7354935 190 µM -0.345946637048962 0.354040925243013 no 2202 0.364691409378835 717 318112
SGTC_213 1246-0773 967 nM -0.347696904493798 0.353373535206064 no 2203 0.364033910824692 705 6251622
SGTC_558 k064-0027 21.3 µM -0.34825848170235 0.353159497009057 no 2204 0.363823035625256 683 5088526
SGTC_1243 0416-0003 5.65 µM -0.348726870194348 0.352981012057127 no 2205 0.363647184818116 711 2141977
SGTC_3029 9088683 49.47 µM -0.350146737340268 0.352440152735832 no 2206 0.36311428846802 696 25236615
SGTC_522 1273-0010 11.6 µM -0.350223800922904 0.352410806007287 no 2207 0.363085372978102 679 5705015
SGTC_493 zm226600 134 µM -0.353769726673594 0.351061428161934 no 2208 0.361755731400371 738 5240098 A potassium channel opener. YCR052W RSC6
SGTC_1781 st038725 66.3 µM -0.354673594965011 0.350717766601069 no 2209 0.361417067355143 681 4270275 YIL048W NEO1
SGTC_2343 7990716 14.84 µM -0.354686431125391 0.350712887017774 no 2210 0.361412258645759 679 6456862
SGTC_2953 9074162 66.49 µM -0.356459918389954 0.350038944388822 no 2211 0.36074808189548 681 16451992
SGTC_1082 camptothecin 424.86 nM -0.357407551780867 0.349679027736188 no 2212 0.360393362054512 679 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_594 1487-1584 10.8 µM -0.357772421855719 0.349540483963406 no 2213 0.360256815243517 733 5013332
SGTC_1299 1079-1439 3.74 µM -0.357938001547291 0.349477618781372 no 2214 0.360194855561186 718 323161
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.358295760633847 0.349341803479798 no 2215 0.360060995166097 688 676296 Flavone; oxidizing agent.
SGTC_3074 9116018 49.47 µM -0.365301139228356 0.34668627282431 no 2216 0.357443314051454 711 17027303
SGTC_1760 st045453 10.4495 µM -0.367237694081949 0.345953502812913 no 2217 0.356720862389834 728 3323419 YIL048W NEO1
SGTC_2594 a-mangostin 100 µM -0.367393937142558 0.345894407340085 no 2218 0.356662596672167 731 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_1987 st072290 61.9 µM -0.368776587558437 0.345371614215614 no 2219 0.356147128507595 720 54697379
SGTC_1244 0416-0015 52.5 µM -0.371335439742875 0.344404866558331 no 2220 0.355193852409683 700 96201
SGTC_2863 9028737 58.44 µM -0.371976882950498 0.344162684939738 no 2221 0.354955030542026 717 6460917
SGTC_1164 k060-0068 93.7 µM -0.37361661388876 0.34354388307203 no 2222 0.354344785791027 698 5963676
SGTC_15 0266-0086 27.098 µM -0.376976898724558 0.342277089156006 no 2223 0.353095386363504 720 1712902 YIL048W NEO1
SGTC_510 ag-490 170 µM -0.37815680378128 0.341832696466597 no 2224 0.352657056251318 721 5328779
SGTC_768 0384-0033 77.3 µM -0.378282022552408 0.341785547632972 no 2225 0.352610549435408 723 3965305 YMR134W ERG29
SGTC_2371 9071574 200 µM -0.379575075788654 0.341298816567943 no 2226 0.352130432574245 726 45596039
SGTC_2301 7769476 200 µM -0.381022346125709 0.340754348086867 no 2227 0.351593333607883 710 977820
SGTC_2165 5727197 32.143 µM -0.381422815388581 0.340603748584093 no 2228 0.351444767036531 718 1361712
SGTC_2319 6033012 152.6 µM -0.383558532799653 0.339801025430182 no 2229 0.350652839700791 694 847246
SGTC_2468 5987765 72.9 µM -0.385282359336106 0.339153643309517 no 2230 0.350014114924954 682 26772094
SGTC_789 1309-1135 70.6 µM -0.385469556011727 0.33908337023293 no 2231 0.349944778945423 697 3092424
SGTC_1429 4049-0205 9.46 µM -0.38641269506261 0.338729403827547 no 2232 0.34959552479332 710 22774478
SGTC_484 loperamide 105 µM -0.388810998746953 0.33782994635565 no 2233 0.348707981980967 700 3955 An opioid-receptor agonist.
SGTC_946 3434-1334 87.4 µM -0.389241882389235 0.337668446080931 no 2234 0.348548611946896 705 4047976
SGTC_2260 7964312 200 µM -0.389430809783975 0.337597643287302 no 2235 0.348478742192544 719 231951
SGTC_992 3909-8734 162 µM -0.390988972898237 0.337013922482423 no 2236 0.347902693370852 737 4288319
SGTC_2349 9023730 187.07 µM -0.391022173078882 0.337001489256889 no 2237 0.34789042316415 731 4126287
SGTC_1556 plumbagin 1.48 µM -0.391266481866032 0.336910002875165 no 2238 0.347800135804533 720 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_2974 9094440 9.66 µM -0.392745011645298 0.336356543439782 no 2239 0.347253911001818 699 25236134
SGTC_3295 9122362 53.5725 µM -0.393269804745916 0.336160182311852 no 2240 0.347060108785307 741 4730473
SGTC_2799 7812892 81.82 µM -0.393350873723792 0.336129852825817 no 2241 0.347030174175605 737 20205235
SGTC_248 streptozotocin 5.23457 mM -0.393758003855359 0.33597755363574 no 2242 0.346879856366409 747 5300 DNA alkylating agent.
SGTC_544 k015-0020 52.4 µM -0.396202692753845 0.335063611733744 no 2243 0.345977752492677 711 3008304
SGTC_613 3914-0030 117 µM -0.397206881173334 0.334688480356789 no 2244 0.345607454140164 694 1145395
SGTC_2059 5238311 157 µM -0.397958614162927 0.334407765853492 no 2245 0.345330346334604 702 703021
SGTC_2989 9073649 71.4286 µM -0.398884935159483 0.33406198346321 no 2246 0.344988994982611 758 21367202
SGTC_2345 9052315 157.45 µM -0.402243857949822 0.332809328405255 no 2247 0.343752283930267 709 6469265
SGTC_2540 epiandrosterone 100 µM -0.402576299667243 0.332685450874406 no 2248 0.343629973895965 712 441302 A steroid.
SGTC_2133 5320837 200 µM -0.403155217352167 0.332469772777128 no 2249 0.343417020925538 734 2841355
SGTC_2805 7950783 58.44 µM -0.403739276821804 0.332252235280164 no 2250 0.343202226926776 700 1178958 YDL195W SEC31
SGTC_1281 0884-0031 11.8 µM -0.404709788822798 0.331890885513738 no 2251 0.342845422978724 705 1548255
SGTC_2357 9067248 200 µM -0.405058593017496 0.331761053763862 no 2252 0.342717221051596 734 9150235
SGTC_574 1315-0397 40 µM -0.40595400745813 0.331427855514689 no 2253 0.342388197138479 715 6794277
SGTC_724 3910-0327 137 µM -0.406166447918657 0.33134882253698 no 2254 0.342310152513804 763 2885483
SGTC_2182 6325192 200 µM -0.407290177190204 0.330930893136387 no 2255 0.341897438206964 687 736248
SGTC_2958 9077254 16.72 µM -0.407300153750814 0.330927183667347 no 2256 0.341893774940619 719 16457351
SGTC_1792 st045773 43.6 µM -0.407614627410132 0.33081026507654 no 2257 0.341778311838209 696 2919270
SGTC_1492 4158-0558 28.5 µM -0.407647672534595 0.330797980142615 no 2258 0.341766179749219 720 3967268
SGTC_3071 9117417 49.47 µM -0.408210648272047 0.330588714953171 no 2259 0.341559515624835 724 45595590 YGL055W OLE1
SGTC_2205 7238770 200 µM -0.408535980225667 0.330467809094399 no 2260 0.341440110378632 717 279867
SGTC_2104 5389443 200 µM -0.40870754142665 0.330404057482143 no 2261 0.341377149368119 742 2244536
SGTC_2116 5511452 16.8835 µM -0.409039307887224 0.330280788053162 no 2262 0.341255407372711 741 870744
SGTC_2747 doxorubicin 7.63 µM -0.409169593878026 0.330232384700333 no 2263 0.341207603330369 704 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_602 3130-1533 38.1 µM -0.411407772537495 0.329401309308384 no 2264 0.340386777776286 733 720941
SGTC_660 4031-1742 102 µM -0.411478181278426 0.329375178935979 no 2265 0.340360968441977 706 6738706
SGTC_41 0478-0632 82.643 µM -0.41355722039486 0.328603973700333 no 2266 0.339599204292012 756 3750424
SGTC_1366 1683-0113 21.9 µM -0.414546220583917 0.328237366724085 no 2267 0.339237062240556 721 708623
SGTC_376 3970-0862 59.1 µM -0.414591742870515 0.328220496299267 no 2268 0.339220396922984 745 3135186
SGTC_1608 st001473 40.5 µM -0.415025124937871 0.328059903735086 no 2269 0.339061755230402 747 7292267
SGTC_224 benfluorex 43.875 µM -0.416674282772808 0.327449088264001 no 2270 0.338458333753944 736 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_827 3253-0474 693 µM -0.416958290306489 0.327343944036324 no 2271 0.338354458123697 749 5402065
SGTC_2415 st077333 57.7 µM -0.417507310066598 0.327140726789538 no 2272 0.338153689265843 744 2766255
SGTC_83 0170-0301 39.027 µM -0.417611224239164 0.327102269180792 no 2273 0.338115694481725 699 3089716
SGTC_1847 st056231 15 µM -0.418546934993555 0.326756054605428 no 2274 0.33777363905721 712 5393180
SGTC_126 0417-1624 672.48 µM -0.418916207702252 0.326619464091482 no 2275 0.337638685753963 751 41912 YDL195W SEC31
SGTC_2891 9063876 19.48 µM -0.419145664401222 0.326534601913832 no 2276 0.337554839707379 735 6472478
SGTC_2432 5630864 12.22 µM -0.420028773333567 0.326208077028414 no 2277 0.337232217087036 755 5714970
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.420433486815943 0.326058480831779 no 2278 0.337084404713125 683 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_1411 3909-8223 150 µM -0.422404215758116 0.325330431142575 no 2279 0.336365000646318 750 X1411
SGTC_1597 7-benzyloxygramine 47.5 µM -0.422568891493902 0.325269624829637 no 2280 0.336304913717671 741 260807
SGTC_637 1181-0519 7.26 µM -0.422814058420468 0.325179105862126 no 2281 0.336215464887245 733 6252091 YGR060W ERG25
SGTC_1091 telmisartan 47.6 µM -0.424121131442359 0.324696690911994 no 2282 0.335738737606783 750 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_1970 st070122 35.8 µM -0.424424742627846 0.32458467602916 no 2283 0.335628039627143 753 102928
SGTC_2618 avocadyne 43.43 µM -0.425521082755513 0.324180322380808 no 2284 0.335228427980412 723 3015189
SGTC_779 1360-0071 233 µM -0.42595276120909 0.324021167002604 no 2285 0.335071134008397 740 7566
SGTC_1290 0986-0249 10.2 µM -0.426247605994769 0.323912479264729 no 2286 0.334963715784706 738 53329
SGTC_881 0833-0569 170 µM -0.426346034576861 0.323876199177095 no 2287 0.334927859164743 705 5418700
SGTC_588 3970-1144 52.9 µM -0.426658506304743 0.323761035369972 no 2288 0.334814038582979 714 1888707
SGTC_2168 5727979 200 µM -0.427365624311264 0.323500484012693 no 2289 0.334556520649721 707 695210
SGTC_591 4299-0174 154 µM -0.42752233873229 0.323442751249078 no 2290 0.334499458988329 734 5509088
SGTC_461 N-acetylfarnesylcysteine 136 µM -0.428405051438778 0.323117643986393 no 2291 0.334178123804392 745 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_1468 k284-1086 134 µM -0.430266164707801 0.322432629996859 no 2292 0.333501018412084 732 15996457
SGTC_1578 josamycin 24.2 µM -0.431629659927741 0.321931154875636 no 2293 0.333005299008184 753 5282165 A P450 substrate.
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.433197094788233 0.321355073967187 no 2294 0.332435794650604 697 6708514
SGTC_894 0960-0238 55.9 µM -0.434383678408124 0.320919253235445 no 2295 0.332004924004974 747 6741907 YDL195W SEC31
SGTC_1455 4262-0120 131 µM -0.435266927625829 0.32059500438424 no 2296 0.33168434385632 722 1529587
SGTC_3020 9089140 49.47 µM -0.43537975599295 0.320553593913611 no 2297 0.331643401053095 715 17217859
SGTC_2031 5180455 200 µM -0.435911816302054 0.320358346288189 no 2298 0.331450355791463 733 29949
SGTC_2163 5671233 125 µM -0.436749053777912 0.320051209940506 no 2299 0.331146675015148 690 701023
SGTC_6 0844-0013 19.835 µM -0.438298490802226 0.319483132088841 no 2300 0.330584959908287 744 1584900
SGTC_2498 4'-Methoxychalcone 54.63 µM -0.440954090415028 0.318510481476275 no 2301 0.329623116804981 725 641818 YHR062C RPP1
SGTC_3292 9120825 59.784 µM -0.441192951051869 0.318423056565094 no 2302 0.329536657934772 762 24824900
SGTC_1149 3909-7961 23.3 µM -0.441374692377497 0.318356544552981 no 2303 0.329470880282576 704 735261
SGTC_1132 3456-3614 2.5 µM -0.441510289322305 0.31830692384882 no 2304 0.329421807106464 749 3125502
SGTC_3116 9124943 49.47 µM -0.443024407944768 0.3177530648831 no 2305 0.328874040132005 709 41905195 YPL160W CDC60
SGTC_554 4483-2211 187 µM -0.443280205478655 0.317659535304307 no 2306 0.328781535776547 730 747107
SGTC_2774 tamoxifen 10.92 µM -0.443457482455834 0.317594722736672 no 2307 0.328717433052995 737 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_3205 9113483 49.47 µM -0.444057957883646 0.317375230111433 no 2308 0.328500340729107 750 17018033
SGTC_1638 st008370 60.6 µM -0.444571795753862 0.317187457207054 no 2309 0.328314616786595 714 24207134
SGTC_887 0885-0007 9.62 µM -0.444729484684592 0.317129842027488 no 2310 0.328257629473282 753 5719458
SGTC_3046 9092212 49.47 µM -0.445250174962307 0.316939627671276 no 2311 0.328069485239088 718 25236637
SGTC_2544 sphondin 68.51 µM -0.445986257715484 0.316670810412715 no 2312 0.327803586328777 711 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_2847 9005661 71.43 µM -0.446383136469229 0.316525910532299 no 2313 0.327660256008649 736 2991449
SGTC_2541 muurolladie-3-one 83.07 µM -0.446750102449803 0.316391956815133 no 2314 0.327527751093888 756 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_1964 st076914 61 µM -0.446934086822726 0.316324806000722 no 2315 0.327461325770432 752 24208661
SGTC_218 alverine citrate 93.75 µM -0.446969045395022 0.316312047468015 no 2316 0.327448705019896 744 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_1312 1218-2183 165 µM -0.447067840196975 0.316275992351861 no 2317 0.327413039167557 754 6744073
SGTC_86 0417-1630 471.922 µM -0.44710018087126 0.316264190017557 no 2318 0.327401364222303 744 3634867
SGTC_1898 st060199 18.6 µM -0.447315730689056 0.316185532524354 no 2319 0.327323555304971 711 688866
SGTC_1484 3473-2379 286 µM -0.449260012042767 0.315476410153956 no 2320 0.326622050298058 741 671917
SGTC_329 k048-0121 21.3 µM -0.4499305577031 0.31523200467507 no 2321 0.326380256499444 735 6832902
SGTC_1892 st058411 7.36 µM -0.449995664029573 0.315208278540329 no 2322 0.326356783523692 762 3934738
SGTC_2608 thymoquinone 42.66 µM -0.450176850273222 0.31514225441896 no 2323 0.326291463533436 752 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_1052 3253-3998 198 µM -0.450710155449965 0.314947952716914 no 2324 0.326099231027604 729 5450317
SGTC_802 4112-3352 742 µM -0.451106356288743 0.314803636060143 no 2325 0.325956448371696 715 704594
SGTC_835 0312-0010 67.2 µM -0.451246643381549 0.314752543087087 no 2326 0.325905897897057 740 1626196
SGTC_1287 0971-0001 34.6 µM -0.451805387192624 0.314549082138519 no 2327 0.325704594208796 714 4665869
SGTC_203 k066-0004 30.888 µM -0.452212719750463 0.314400791559088 no 2328 0.325557872843149 746 6795412
SGTC_534 k292-0788 63.4 µM -0.45242740163218 0.314322648055791 no 2329 0.325480555208736 754 4146317
SGTC_2300 7976697 71.57 µM -0.453916284154698 0.313780928789224 no 2330 0.324944541269658 723 2236109
SGTC_2120 5538279 151.968 µM -0.454301753789533 0.313640743752372 no 2331 0.324805826975104 743 2058197
SGTC_1951 sophoraflavanone G 9.2 µM -0.456011366875691 0.313019327540361 no 2332 0.324190902176568 748 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_741 4582-0002 126 µM -0.456306567676354 0.312912080599056 no 2333 0.324084770902 717 2912688
SGTC_88 0180-0332 8.668 µM -0.456678022605194 0.312777152900026 no 2334 0.3239512448788 727 3101745
SGTC_2461 5755302 26.15 µM -0.457226420038122 0.312577998261195 no 2335 0.323754155158658 775 2788904
SGTC_603 3794-0023 45.9 µM -0.459626677965228 0.311706971045158 no 2336 0.322892103405812 765 3802260
SGTC_1675 st018485 24.5 µM -0.459723487847935 0.311671861850221 no 2337 0.322857354087367 751 3323024
SGTC_258 haloperidol 50.781 µM -0.461239977141097 0.31112211352294 no 2338 0.322313221499321 741 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_439 amiodarone 34.4 µM -0.463776269392653 0.310203614042709 no 2339 0.321404023470334 734 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_1990 st072050 59.8 µM -0.464660657026785 0.309883617414339 no 2340 0.321087243473351 728 17233948
SGTC_1670 st016595 4.04 µM -0.464802488581652 0.309832312110308 no 2341 0.321036452742778 759 597879
SGTC_2680 butyl paraben 22.24 µM -0.46567119943858 0.309518150652165 no 2342 0.320725435261426 761 7184 An antifungal and steroid mimetic.
SGTC_1177 0983-0204 23.6 µM -0.46570131039724 0.309507263788937 no 2343 0.320714657134419 743 766818
SGTC_1819 st053448 58.6 µM -0.466236074381257 0.309313943354246 no 2344 0.320523265160515 775 2857616
SGTC_1215 3852-0577 11.2 µM -0.466933600230451 0.309061862827482 no 2345 0.320273692444791 730 2884876
SGTC_2086 5274770 176.623 µM -0.467492323656244 0.308860009264042 no 2346 0.320073841449483 745 689278
SGTC_1904 st060225 78 µM -0.467958376011452 0.308691679716199 no 2347 0.31990717809502 713 66595
SGTC_2959 9079155 11 µM -0.470147534789458 0.307901533993914 no 2348 0.319124807446813 781 16189457
SGTC_2487 5918373 44.05 µM -0.47167866699422 0.307349422160291 no 2349 0.318578083197719 759 2876279
SGTC_1021 4476-0760 85.3 µM -0.471775462859236 0.307314533134221 no 2350 0.318543533371126 737 746768
SGTC_3143 9086658 49.47 µM -0.473251532552061 0.306782715911919 no 2351 0.318016868138266 728 25236626
SGTC_84 0443-0269 128.823 µM -0.477070138954637 0.305408787468348 no 2352 0.316656088734689 755 6150058
SGTC_3267 9137951 49.47 µM -0.477858554851519 0.305125456877433 no 2353 0.316375440771449 752 16643986
SGTC_2015 5119600 184 µM -0.479309466098107 0.304604352587469 no 2354 0.315859244452823 778 2828786
SGTC_2978 9011784 42.97 µM -0.479834013350834 0.304416055476049 no 2355 0.315672712520005 726 2994934
SGTC_216 k038-0035 28.382 µM -0.480868637746987 0.304044807570049 no 2356 0.315304931954079 740 4444231 YPR107C YTH1
SGTC_1507 4075-3230 155 µM -0.481168348312503 0.303937301981274 no 2357 0.315198427234875 766 659771
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.481375420057003 0.303863035657586 no 2358 0.315124851485653 728 688664
SGTC_3346 9158254 43.5805 µM -0.481535885713428 0.303805490184154 no 2359 0.315067840633741 773 17639500
SGTC_1881 5652484 16 µM -0.481989041092056 0.303643007895139 no 2360 0.314906865647089 762 2255129
SGTC_1055 3448-0672 86 µM -0.483405587699462 0.30313534475177 no 2361 0.31440389074322 758 748378
SGTC_555 4296-0685 37 µM -0.484022050484533 0.302914534922661 no 2362 0.314185110038197 765 2908540 YHR072W ERG7
SGTC_141 0443-0274 32.331 µM -0.484611551404376 0.302703449890284 no 2363 0.313975959064321 743 1627241
SGTC_1114 scopoletin 1.73284 µM -0.484653344079058 0.30268848751612 no 2364 0.313961133570722 755 5280460 A coumarin with genotoxic properties.
SGTC_2069 5228469 200 µM -0.484695677769002 0.302673331788572 no 2365 0.313946116464027 770 2835210
SGTC_966 1300-0360 30.2 µM -0.484723515010186 0.302663366066245 no 2366 0.313936241876846 769 70588
SGTC_1283 0922-0125 16.4 µM -0.485161208010979 0.30250669146223 no 2367 0.313780998405581 742 3360884
SGTC_3184 9108758 49.47 µM -0.486222693766225 0.302126877929555 no 2368 0.313404641482386 756 902885
SGTC_2934 9036370 36.88 µM -0.486422580093639 0.302055379938231 no 2369 0.31333379215632 728 6462800
SGTC_2171 5739187 198.077 µM -0.486452384047624 0.302044719915822 no 2370 0.313323228791946 726 2262761
SGTC_1450 4112-4260 37.6 µM -0.48978655811926 0.300853249498897 no 2371 0.312142471743845 759 1633175
SGTC_902 1120-0002 2.07 µM -0.490681783454166 0.30053370121779 no 2372 0.311825766304726 757 3280475
SGTC_1783 st039459 87.517 µM -0.494984695496756 0.298999931828243 no 2373 0.310305461879678 792 729761
SGTC_2322 7413319 38.22 µM -0.495376828346993 0.298860333305565 no 2374 0.310167074042936 763 1840400
SGTC_1081 sertraline 6 µM -0.495669734190976 0.298756078726857 no 2375 0.310063722004584 763 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_2136 5328288 199.296 µM -0.495903943576342 0.298672727994518 no 2376 0.309981091848903 742 262395
SGTC_2117 5521686 200 µM -0.498487734086928 0.297753907934423 no 2377 0.309070156255311 750 803312
SGTC_3085 9117376 49.47 µM -0.498973979040487 0.297581138947819 no 2378 0.308898857739274 740 16480349
SGTC_2773 thioridazine 9.09 µM -0.49922717045027 0.297491194956038 no 2379 0.308809677762745 765 5452 An antipsychotic.
SGTC_1414 3917-0015 5.4 µM -0.500642941970558 0.2969884836703 no 2380 0.308311217546421 769 6618702
SGTC_1286 0929-0070 131 µM -0.501667478545064 0.296624934382909 no 2381 0.307950722279093 769 1420408
SGTC_1063 disulfiram 1.84 µM -0.502674266758962 0.296267881673172 no 2382 0.307596652432923 751 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.50415173524869 0.295744261601732 no 2383 0.307077376971577 760 442882
SGTC_1855 st056195 39.6 µM -0.505746146268226 0.29517967420138 no 2384 0.306517434330538 733 4028379
SGTC_2153 5569715 200 µM -0.508473584753435 0.294215029439788 no 2385 0.305560629728881 750 2054701
SGTC_3265 9137266 49.47 µM -0.511125675343323 0.29327843283123 no 2386 0.304631529215409 728 17224265
SGTC_1568 digitonin 820 nM -0.511132464016262 0.293276037157915 no 2387 0.304629152568856 797 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_1919 st067113 52.3 µM -0.511996694808908 0.292971130502891 no 2388 0.304326661383231 754 1268243
SGTC_2051 5263410 176 µM -0.51482441406099 0.291974520861875 no 2389 0.303337861695929 776 227584
SGTC_2342 7990637 118.86 µM -0.514884301096357 0.291953431180432 no 2390 0.303316935871691 798 2033102 YER133W GLC7
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.517098645949472 0.291174131072511 no 2391 0.302543649399489 747 6708784 An antioxidant flavonoid
SGTC_2449 5812982 45.77 µM -0.51799279070039 0.290859727918241 no 2392 0.302231649666198 774 776185
SGTC_648 0375-0473 33.3 µM -0.518809720222916 0.290572614325168 no 2393 0.30194671943627 767 1713139
SGTC_3257 9139206 32.98 µM -0.520797298574522 0.289874625260656 no 2394 0.301253992582963 773 4910041
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.522529712248034 0.289266886003576 no 2395 0.300650782295441 774 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1653 st012112 65 µM -0.522932490199658 0.28912567536236 no 2396 0.300510616919617 784 720429
SGTC_1818 st052136 56.3 µM -0.525863316058806 0.288099129298283 no 2397 0.299491589284808 770 674169
SGTC_3275 9138069 49.47 µM -0.525925378795827 0.288077409918635 no 2398 0.299470027451069 775 17617007
SGTC_2699 st077704 54.6 µM -0.525939933684183 0.288072316424235 no 2399 0.299464970894185 772 645852
SGTC_1264 0783-0040 158 µM -0.526178774792035 0.287988739866149 no 2400 0.299381999927044 753 2855798
SGTC_2070 5230947 200 µM -0.527616462084017 0.287485898622286 no 2401 0.298882782408996 803 2835538
SGTC_1174 0739-0097 51.1 µM -0.527695128069034 0.287458396625093 no 2402 0.298855477622978 768 728447
SGTC_908 3448-7491 47.7 µM -0.528234603999258 0.287269826842884 no 2403 0.298668257289547 745 1203031
SGTC_2622 2-methoxyxanthone 59.94 µM -0.530843955768522 0.286358574732764 no 2404 0.297763458629934 764 71034 A hepatoprotective.
SGTC_134 0269-0018 6.916 µM -0.531332696785287 0.286188046611459 no 2405 0.297594125698479 741 4378915
SGTC_717 1532-0246 73.2 µM -0.532096841495257 0.285921523245715 no 2406 0.297329462429822 774 9561992
SGTC_2092 5303694 80.6725 µM -0.532453204548228 0.285797268978836 no 2407 0.297206072051639 779 1963699
SGTC_3273 9137859 49.47 µM -0.532700755310934 0.285710969766273 no 2408 0.297120371607505 793 2377234
SGTC_1640 st009078 66.4 µM -0.532714081835668 0.28570632432902 no 2409 0.297115758372903 769 690618
SGTC_1430 4049-0248 69.1 µM -0.534678900225384 0.285021810054372 no 2410 0.296435957122259 783 22774488
SGTC_1384 3089-0840 101 µM -0.534678988390864 0.285021779356349 no 2411 0.296435926634167 758 1069836
SGTC_1887 st057648 70.8 µM -0.53830377203532 0.28376101333066 no 2412 0.295183673822404 784 688672
SGTC_1992 st073643 23.3 µM -0.539134458627421 0.283472461902441 no 2413 0.294897040183158 784 3161292
SGTC_1984 st072354 53.1 µM -0.540906853764182 0.282857264491265 no 2414 0.294285893308117 766 5762938
SGTC_586 0957-0265 8.15 µM -0.540962050620875 0.282838115991761 no 2415 0.294266870048257 771 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_721 1187-1332 279 µM -0.540982753692062 0.282830933990655 no 2416 0.294259735007575 782 25730
SGTC_2166 5933061 31.504 µM -0.542635630259938 0.282257825519869 no 2417 0.293690350930777 757 2877375
SGTC_913 3487-1245 167 µM -0.542770991197598 0.282210916051769 no 2418 0.293643744298828 742 4016153
SGTC_3232 9132874 49.47 µM -0.544641915651566 0.28156292995965 no 2419 0.292999910279824 774 3784940
SGTC_2273 7815444 169.05 µM -0.545238257944505 0.281356540473189 no 2420 0.292794831042806 832 2824616
SGTC_2857 9024691 58.44 µM -0.545286788936009 0.28133974748337 no 2421 0.292778144401943 806 16478292
SGTC_1575 cyproterone acetate 48 µM -0.54533194066691 0.281324124240376 no 2422 0.2927626200648 796 9880 An androgen receptor antagonist and liver toxin.
SGTC_2132 5317594 122.667 µM -0.54561505892992 0.281226170202617 no 2423 0.292665285370522 795 794577
SGTC_1218 1348-1416 30.7 µM -0.54614043730591 0.281044441990722 no 2424 0.292484702656914 772 6787668
SGTC_3279 9140807 49.47 µM -0.546737801809077 0.280837882756858 no 2425 0.292279439861745 785 45595718
SGTC_529 4076-0302 30.3 µM -0.547306351401559 0.280641355463932 no 2426 0.292084140528375 776 5816522
SGTC_1230 0170-0365 3.77 µM -0.547606857597238 0.280537508086109 no 2427 0.291980939845615 776 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_1146 3579-1023 7 µM -0.54850308030164 0.280227906560732 no 2428 0.291673257392425 804 X1146
SGTC_3278 9139605 49.47 µM -0.549030220765457 0.280045882411879 no 2429 0.291492355276657 793 7958859
SGTC_1922 5578187 25 µM -0.549053287515319 0.280037918660703 no 2430 0.291484440509907 758 1350412
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.549426488766208 0.279909086902665 no 2431 0.291356399954079 776 2374 Ca(2+)-ATPase inhibitor.
SGTC_181 1447-1644 8.07 µM -0.549445835730922 0.279902408974899 no 2432 0.291349762974592 786 534600
SGTC_2561 acetosyringone 100 µM -0.552698318020607 0.278780860108332 no 2433 0.290235002646784 801 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_1873 rapamycin 2 nM -0.552982154994372 0.27868308887248 no 2434 0.2901378148323 754 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_2565 isoliquiritigenin 100 µM -0.552997899787562 0.278677665868073 no 2435 0.290132424148717 746 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_297 0986-0032 24 µM -0.556816263022734 0.277364020271825 no 2436 0.288826485608493 791 2847425
SGTC_2134 5324836 1.464 µM -0.55796199978723 0.276970439610955 no 2437 0.288435166532361 794 699272
SGTC_1711 st032263 62.8 µM -0.558737886117884 0.27670406442144 no 2438 0.288170309508319 785 3958979
SGTC_2003 4023581 200 µM -0.55882466440118 0.276674279743384 no 2439 0.288140693956942 763 16641307
SGTC_1676 st018489 23.4 µM -0.559264247612725 0.276523426914214 no 2440 0.287990695779916 784 3696235
SGTC_986 1493-0483 84 µM -0.559450769110559 0.276459430070227 no 2441 0.287927060530236 782 40079
SGTC_1840 st055363 71 µM -0.559484162665966 0.27644797327198 no 2442 0.287915668403569 784 676033
SGTC_1307 1187-1599 12.2 µM -0.560006618131949 0.276268757426371 no 2443 0.28773746176718 785 1538471
SGTC_2409 alverine citrate 63.97 µM -0.56032593182151 0.276159252581132 no 2444 0.287628571319622 738 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_3175 9106517 49.47 µM -0.561166864481962 0.275870966666987 no 2445 0.287341894713919 811 41468073
SGTC_712 r015-0009 80.6 µM -0.561343991588054 0.275810263360695 no 2446 0.287281528762575 767 6813872 YLR060W FRS1
SGTC_2444 5485484 36.41 µM -0.561721504874458 0.27568090752697 no 2447 0.287152890060871 803 6790631
SGTC_165 k038-0023 64.381 µM -0.561897910766191 0.275620471850587 no 2448 0.287092788612844 770 46368543
SGTC_400 oxethazaine 37.5 µM -0.562007850385461 0.275582810444374 no 2449 0.287055335222123 785 4621 A local anesthetic.
SGTC_3156 9099931 49.47 µM -0.563862182830918 0.274947963627309 no 2450 0.286423964317037 784 18111053
SGTC_823 0417-1665 178 µM -0.563863217006739 0.274947609769389 no 2451 0.286423612380463 802 3429856
SGTC_1194 1488-0194 225 µM -0.564799524146507 0.274627331107717 no 2452 0.286105065371997 786 1391452
SGTC_619 1652-1634 108 µM -0.565773077982663 0.274294506885776 no 2453 0.28577402502448 793 5400454
SGTC_1394 3474-0001 65.7 µM -0.567863817683816 0.273580429424061 no 2454 0.285063721077252 757 5017666 YIL048W NEO1
SGTC_2038 4100038 30.985 µM -0.569921327314128 0.272878600756088 no 2455 0.284365529465077 775 3596803
SGTC_926 2268-1401 59.4 µM -0.571494884295349 0.272342454457459 no 2456 0.283832113546394 792 2931578
SGTC_804 1595-0054 20.9 µM -0.57182507133804 0.272230018759294 no 2457 0.283720245145487 792 761523 Stimulates phospholipase C.
SGTC_877 0771-0151 33.1 µM -0.574550776968858 0.271302740276977 no 2458 0.282797575108002 785 6166523
SGTC_1339 1486-1321 22.7 µM -0.575241979442466 0.271067845325309 no 2459 0.282563827642151 785 3469382
SGTC_2654 protoveratrine a 100 µM -0.576190371784568 0.270745713353427 no 2460 0.282243256198726 816 5702278 A heart drug and vasodilator.
SGTC_677 0929-0063 136 µM -0.576290881718482 0.270711585244528 no 2461 0.2822092925294 813 1539583
SGTC_476 mead acid 10 µM -0.576327723760115 0.270699076081649 no 2462 0.282196843596737 790 5312531 An omega 9 fatty acid.
SGTC_3214 9129694 49.47 µM -0.576486477625834 0.270645176888364 no 2463 0.282143203659857 813 17158655
SGTC_2344 7990960 76.95 µM -0.578341592461876 0.270015736566664 no 2464 0.281516759420706 807 140813
SGTC_2464 5717415 7.67 µM -0.580035526686534 0.269441625336673 no 2465 0.280945330135812 774 5285744
SGTC_2939 9044578 71.43 µM -0.5803990432266 0.269318501452022 no 2466 0.2808227750986 787 2653634
SGTC_2316 5844804 197.44 µM -0.580729751037873 0.269206514473303 no 2467 0.280711303571686 784 776813
SGTC_2135 5326629 150.42 µM -0.581205269554324 0.269045531463551 no 2468 0.280551058288898 796 5020077
SGTC_99 0109-0120 622.8 µM -0.584292038391578 0.268001706597832 no 2469 0.279511923879628 799 759414
SGTC_2693 st077581 40.7 µM -0.585753658066162 0.267508156129607 no 2470 0.27902053491259 800 25238761
SGTC_1591 genipin 88.4 µM -0.585908989289918 0.267455731821011 no 2471 0.278968338067163 825 442424 A DNA cross-linking agent.
SGTC_1594 piperine 70.1 µM -0.58625384685967 0.267339360869744 no 2472 0.278852470573784 789 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_1436 4092-1007 8.32 µM -0.587301099654152 0.266986125812331 no 2473 0.278500751361993 761 2881121
SGTC_2240 6690706 185.951 µM -0.587991755232504 0.266753298927422 no 2474 0.278268913431518 778 805876
SGTC_1743 st037606 46.3785 µM -0.588105636587106 0.266714918244325 no 2475 0.278230694996572 754 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_1800 st050079 29.0735 µM -0.588262827334541 0.266661945867601 no 2476 0.278177946190391 792 3645560
SGTC_2727 riluzole 51.77 µM -0.588625184892286 0.266539853723117 no 2477 0.278056367739352 797 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_3135 9127742 49.47 µM -0.589386646024915 0.26628338045109 no 2478 0.277800966295396 790 3643468
SGTC_1486 3970-0793 4.53 µM -0.590623478940746 0.265867060125798 no 2479 0.277386364832043 797 2844330
SGTC_1100 amiodarone 5.07 µM -0.59094724487216 0.265758134393305 no 2480 0.27727788452953 771 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_3013 9080133 71.4286 µM -0.592272881114742 0.265312381909604 no 2481 0.276833936283726 792 17050193
SGTC_1848 st056003 16.4 µM -0.593384054585809 0.264939036321527 no 2482 0.27646207884399 790 146492
SGTC_2385 9074692 200 µM -0.594012157159815 0.264728116947353 no 2483 0.276251990900153 775 17046906
SGTC_1889 st059080 5.18 µM -0.594880556926656 0.264436645507444 no 2484 0.275961657365879 796 176925 Isolated from Daphnopsis sellowiana.
SGTC_2866 9034245 58.44 µM -0.595588905764373 0.264199014891893 no 2485 0.27572494495654 779 6462273
SGTC_943 3253-1379 105 µM -0.596746613847058 0.263810871476098 no 2486 0.275338282939391 814 668464
SGTC_52 0329-0193 875 nM -0.59676395452489 0.263805059898597 no 2487 0.275332493368983 821 3739292
SGTC_81 0411-0046 9.971 µM -0.597178517980258 0.263666141997442 no 2488 0.275194099992323 800 12925265
SGTC_583 1488-1091 88.9 µM -0.59753023321802 0.263548313450376 no 2489 0.275076714044775 809 4303273
SGTC_3307 9126885 69.2785 µM -0.597855870191692 0.263439245374942 no 2490 0.274968053782471 781 24824909
SGTC_882 0843-0131 351 µM -0.598532491671839 0.263212693081992 no 2491 0.274742342805352 792 5425421
SGTC_2873 9040596 71.43 µM -0.598801162923718 0.263122761847866 no 2492 0.274652743371616 837 6463863
SGTC_53 0973-0023 39.979 µM -0.599693076492726 0.262824327861606 no 2493 0.274355401630006 814 674768
SGTC_3296 9122258 64.045 µM -0.6013079844595 0.262284420986278 no 2494 0.273817436253971 802 4730474
SGTC_740 k014-0057 261 µM -0.601376900140931 0.262261393278584 no 2495 0.273794490363654 798 4012779
SGTC_537 1334-0398 209 µM -0.603786674135255 0.261456835406307 no 2496 0.272992740112848 793 5846986
SGTC_2090 5301565 104.445 µM -0.606632354231879 0.260508375018072 no 2497 0.272047461849505 793 2056344
SGTC_737 1950-0117 57.9 µM -0.607120140509569 0.260345974722452 no 2498 0.271885592516223 797 5393513
SGTC_278 4092-0821 23.9 µM -0.607959054259664 0.260066794430593 no 2499 0.271607315475329 805 877900
SGTC_2446 5162541 200 µM -0.609081129896527 0.259693622749545 no 2500 0.271235332317396 806 1549321
SGTC_2733 amorolfine 100 µM -0.611040197904489 0.259042753430167 no 2501 0.270586484311057 826 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1181 1222-0449 220 µM -0.611582241241685 0.258862817223198 no 2502 0.270407095296803 812 658318
SGTC_1199 1638-0010 4.46 µM -0.611634263780558 0.258845551270839 no 2503 0.270389881586034 794 3111136
SGTC_1107 amlodipine 47 µM -0.61461747067536 0.257856441485771 no 2504 0.269403686973503 781 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_3241 9133421 49.47 µM -0.61526467108343 0.257642115414493 no 2505 0.269189972435093 829 17018221
SGTC_597 k018-0003 82.8 µM -0.615662120488045 0.257510542429512 no 2506 0.269058771302514 822 6786234
SGTC_2112 5488546 200 µM -0.616471543350554 0.257242696325225 no 2507 0.268791673803271 822 600757
SGTC_663 1486-0733 13.9 µM -0.618099396404267 0.256704462340932 no 2508 0.268254910080182 815 722445 YPR165W RHO1
SGTC_13 0199-0087 65 µM -0.620182027655818 0.256016716201584 no 2509 0.267568976265708 798 4589825
SGTC_374 0880-0231 82.3 µM -0.620353827491589 0.255960025786629 no 2510 0.267512431911033 806 6833587
SGTC_668 1682-0499 62.6 µM -0.621158639121013 0.255694541724371 no 2511 0.267247625098999 821 682214
SGTC_812 4251-0442 148 µM -0.621623047850179 0.25554141217446 no 2512 0.267094881114276 804 5723007
SGTC_1000 4048-0884 8.67 µM -0.621769989148779 0.255492971179936 no 2513 0.267046561316745 812 13040088
SGTC_1185 1319-0113 81.3 µM -0.622214509445527 0.255346458846914 no 2514 0.266900413288736 812 4672763
SGTC_2705 st078069 42.8 µM -0.622355467436226 0.255300008758996 no 2515 0.266854077989618 803 1530061
SGTC_395 anisomycin 6.25 µM -0.623530707770788 0.254912902139969 no 2516 0.266467914691511 820 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_3075 9116269 49.47 µM -0.623580372779786 0.254896549994969 no 2517 0.266451601870696 817 17015205 YNL244C SUI1
SGTC_2713 st079149 53.4 µM -0.623611667611214 0.254886246490983 no 2518 0.266441323123111 806 3103253
SGTC_2715 st079500 56.4 µM -0.626165765884832 0.254046071101306 no 2519 0.265603109606489 809 28246688
SGTC_2834 9001755 58.44 µM -0.626601281337998 0.253902952614179 no 2520 0.265460314100027 802 2989575
SGTC_423 5-fluorouracil 457 µM -0.627786165473479 0.253513791900627 no 2521 0.265072015076967 816 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1865 st057639 52.2 µM -0.631088726250985 0.252430762483538 no 2522 0.263991256042477 821 688818
SGTC_1247 0448-0043 5.84 µM -0.631371911242613 0.252338009498649 no 2523 0.263898688740223 814 3089013 YGL099W LSG1
SGTC_2982 9019404 25.97 µM -0.632894182330891 0.251839720531316 no 2524 0.263401373580082 774 22333232
SGTC_344 k064-0035 6.43 µM -0.633083765781406 0.251777700079858 no 2525 0.263339471533308 799 5088750
SGTC_215 1287-0124 461.5 µM -0.636661775293904 0.250608701723318 no 2526 0.262172588552594 810 5560863
SGTC_349 k015-0014 24 µM -0.637711298675452 0.250266350241854 no 2527 0.261830814615505 799 2196908
SGTC_1816 st051957 91.6 µM -0.637967240706339 0.250182900320705 no 2528 0.26174750258395 821 674121
SGTC_103 0844-0104 51.839 µM -0.639091441330227 0.249816529453737 no 2529 0.261381723673355 815 5375804
SGTC_1700 st030840 7.9285 µM -0.639541431452459 0.249669959986828 no 2530 0.261235384893919 821 5499307
SGTC_3164 9100705 49.47 µM -0.640077999214062 0.249495250421596 no 2531 0.261060945724602 785 17174235
SGTC_1926 methyl fluorone black 53.6 µM -0.641655344451957 0.248982034112505 no 2532 0.26054849485417 785 72721 Reacts with homocysteine.
SGTC_1444 4112-3581 28 µM -0.642281132957579 0.248778578854749 no 2533 0.260345331102768 815 2877249
SGTC_770 0389-1121 67.2 µM -0.642666158393494 0.248653444062373 no 2534 0.260220372229427 813 6753108
SGTC_3281 9140613 49.47 µM -0.644498386796948 0.248058422213794 no 2535 0.259626151691818 794 16013766
SGTC_209 4077-0173 175.592 µM -0.644501173129561 0.248057517922489 no 2536 0.259625248574001 796 15993494
SGTC_2927 9011802 47.9 µM -0.645669403360488 0.247678529227763 no 2537 0.259246739828414 808 43912568
SGTC_1454 4239-0054 42.6 µM -0.645972200101376 0.247580348614267 no 2538 0.25914867968793 815 1340767
SGTC_1208 2323-2347 50.3 µM -0.647761055790893 0.247000743899531 no 2539 0.258569753731902 810 5412760
SGTC_260 nsc-65238 3.989 µM -0.648055510859015 0.246905407547737 no 2540 0.258474523703705 808 3246252
SGTC_1466 k213-0079 57.5 µM -0.648777538978252 0.246671718324782 no 2541 0.258241088732185 840 3657981
SGTC_1728 st035614 33.7865 µM -0.649412538579261 0.246466294399169 no 2542 0.258035880825749 806 15945546
SGTC_109 0132-0036 33.701 µM -0.6502228208015 0.246204299290251 no 2543 0.257774151057634 788 67274 A color developer.
SGTC_2026 5148700 152 µM -0.650448252505841 0.246131435195706 no 2544 0.257701358729979 805 79838
SGTC_1046 2001-0062 216 µM -0.651377591687997 0.2458311760981 no 2545 0.25740138604911 828 739778
SGTC_230 MPP+ 141.667 µM -0.652230483161646 0.245555789514357 no 2546 0.257126248952067 825 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_2448 5185112 27.17 µM -0.653391474342371 0.245181188381108 no 2547 0.256751966873847 797 5718189
SGTC_2990 9074105 71.4286 µM -0.656622361445652 0.244140341732663 no 2548 0.255711883443194 834 6502001
SGTC_1277 0873-0036 22 µM -0.657796342737416 0.243762728754756 no 2549 0.255334502388275 820 5965735
SGTC_195 4234-0266 16.654 µM -0.658726589773081 0.243463737325697 no 2550 0.255035677558533 821 2303354
SGTC_1015 4130-4525 82 µM -0.658998225487204 0.243376468065707 no 2551 0.254948454082844 822 1363237
SGTC_2865 9030313 51.95 µM -0.660344254678328 0.242944274555153 no 2552 0.254516468355587 822 42562754
SGTC_2148 5546263 113.568 µM -0.660827411413483 0.242789240167033 no 2553 0.254361500804939 809 792097
SGTC_2043 5101342 149 µM -0.661855891691603 0.242459401808538 no 2554 0.254031791099942 831 678451
SGTC_2247 cerulenin 830 nM -0.662190847377473 0.242352032402495 no 2555 0.25392445959357 805 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_1791 st048313 56.1 µM -0.662858760654721 0.242138011005315 no 2556 0.253710507904178 801 1204976
SGTC_1172 0370-0043 85 µM -0.663311551539262 0.241992980204052 no 2557 0.253565519916519 815 376585
SGTC_2290 7904846 200 µM -0.664332360338568 0.241666183824047 no 2558 0.253238806893386 815 2962154
SGTC_1239 0337-0584 35.4 µM -0.664343959523724 0.241662471898767 no 2559 0.253235095810482 830 914301 YML130C ERO1
SGTC_2875 9039966 71.43 µM -0.664863054805804 0.241496384774285 no 2560 0.253069043974627 826 6463691
SGTC_371 0195-0006 7.36 µM -0.668274478373792 0.240406426815457 no 2561 0.251979200690537 813 3928593
SGTC_101 0490-5701 117.494 µM -0.668899319259573 0.240207079403173 no 2562 0.251779852245878 813 4661669
SGTC_3302 9125395 16.351 µM -0.669269537864589 0.240089008453908 no 2563 0.251661777468198 810 17599668
SGTC_590 k048-0076 22.4 µM -0.67010006156257 0.239824251107857 no 2564 0.251397002828299 839 6832814
SGTC_420 mitomycin C 81.9 mM -0.670693095136117 0.239635299234063 no 2565 0.251208031238275 818 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_665 3914-0008 307 µM -0.671626631752398 0.239338021260649 no 2566 0.250910709795445 827 1069549
SGTC_33 0986-0033 35.816 µM -0.672484889673475 0.239064893073225 no 2567 0.250637528232778 793 2848082
SGTC_2227 7312221 64.1025 µM -0.673724463161407 0.238670717639918 no 2568 0.250243253042823 844 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_803 4488-1585 147 µM -0.674045088012812 0.238568819170639 no 2569 0.2501413244119 808 747204
SGTC_3076 9116187 49.47 µM -0.67433562679178 0.238476502989701 no 2570 0.250048979352767 806 27241210
SGTC_2534 helenine 20.12 µM -0.674404642904283 0.238454576592683 no 2571 0.250027045879729 813 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_2757 clomiphene 4.22 µM -0.674450713891257 0.23843994046912 no 2572 0.250012404986463 845 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_2242 6630449 61.2675 µM -0.674918634591314 0.238291316322604 no 2573 0.249863730301855 815 691249 YDR170C SEC7
SGTC_186 3455-3465 67.277 µM -0.675183957001189 0.238207065368499 no 2574 0.249779448997376 828 755278
SGTC_1953 st076800 12.1 µM -0.675907474087164 0.237977401408522 no 2575 0.249549696045455 820 297591
SGTC_1064 honokiol 6.76 µM -0.677706717454617 0.237406799369451 no 2576 0.248978833202768 831 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_386 1509-0011 3.07 µM -0.680320063605146 0.236579356854267 no 2577 0.248150911613976 815 3107280
SGTC_3340 9146634 11.102 µM -0.681142706149635 0.236319218990394 no 2578 0.247890598389234 808 4907387
SGTC_2000 st075254 36.4 µM -0.683082267141086 0.235706510554829 no 2579 0.247277430000629 809 17234175
SGTC_2702 st077768 96.8 µM -0.683512937616911 0.235570580461052 no 2580 0.247141388920976 807 6484119
SGTC_1725 st036284 20.55 µM -0.684580264137803 0.235233892678797 no 2581 0.246804412221262 823 707914
SGTC_805 3852-0218 479 µM -0.685685135288635 0.234885641525828 no 2582 0.246455841188655 818 6615355
SGTC_2374 9071832 200 µM -0.687000082938909 0.234471546676947 no 2583 0.246041338080012 821 17381698
SGTC_1975 st070967 30.8 µM -0.687014305827815 0.234467069905382 no 2584 0.246036856728912 834 261391
SGTC_1786 berberine 21.6 µM -0.688808129485258 0.233902828371075 no 2585 0.245472009549001 837 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.68884139143902 0.233892373038446 no 2586 0.245461542460505 834 94937 An inhibitor of serotonin biosynthesis.
SGTC_2516 gossypol 71.55 µM -0.69215117441931 0.23285329459119 no 2587 0.244421198601692 841 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2206 7254556 146.969 µM -0.693158444722175 0.232537580336171 no 2588 0.244105061690574 818 4398905
SGTC_2071 5230951 39.92 µM -0.693838079393765 0.232324693260957 no 2589 0.243891879545131 845 1799272
SGTC_507 nimesulide 162 µM -0.695454981109666 0.231818655077927 no 2590 0.243385107348958 825 4495 A COX2 inhibitor.
SGTC_396 dithiazanine 1.25 µM -0.695779176234917 0.231717266387852 no 2591 0.243283566062652 824 10578 An antihelmenthic.
SGTC_1995 st072814 61.1 µM -0.695903536399622 0.231678380583574 no 2592 0.243244621242378 833 5769371
SGTC_2583 asiatic acid 100 µM -0.695959713426186 0.23166081595125 no 2593 0.243227029863478 856 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_2797 7859098 81.82 µM -0.698148469793041 0.230977044796863 no 2594 0.24254217430441 832 972681
SGTC_2766 oltipraz 83.91 µM -0.698206889729732 0.230958809761301 no 2595 0.242523909195122 827 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_2598 perillyl alcohol 100 µM -0.698207491660229 0.230958621880583 no 2596 0.242523721004233 835 10819 An apoptosis inducer.
SGTC_1966 st070145 16.1 µM -0.698705032781103 0.230803353431989 no 2597 0.242368194043953 846 3748532
SGTC_2023 5144124 124 µM -0.69874087878933 0.230792169163049 no 2598 0.24235699098573 841 2830192
SGTC_2403 6032726 181.2 µM -0.700916288029938 0.230113989271004 no 2599 0.241677629459195 836 2881040
SGTC_1025 k007-0731 70 µM -0.700931352058859 0.230109296977597 no 2600 0.241672928699762 838 6256118
SGTC_889 0919-1524 82.7 µM -0.701252964950482 0.230009130571266 no 2601 0.241572580615988 840 3905452
SGTC_2075 5212009 200 µM -0.704456516774375 0.22901271677233 no 2602 0.240574260207606 843 780898
SGTC_361 000s-0510 1.45 µM -0.704645563587382 0.228953992540685 no 2603 0.240515417962319 839 660
SGTC_920 mycophenolic acid 780.421 nM -0.704648712859141 0.228953014343626 no 2604 0.240514437794119 827 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_689 0833-0039 98 µM -0.705277499578625 0.228757753534004 no 2605 0.240318780018879 875 5374726
SGTC_3238 9133470 49.47 µM -0.706359025256097 0.228422119850953 no 2606 0.239982447698431 815 3534688
SGTC_2675 theaflavin digallate 100 µM -0.706605437382465 0.228345688626353 no 2607 0.239905854495475 839 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_1883 5-benzylidenerhodanine 20 µM -0.70688504988842 0.228258976838233 no 2608 0.239818957645493 820 1273210
SGTC_1522 st012842 45.6 µM -0.707668399172204 0.22801614775015 no 2609 0.239575602969296 839 3491067 YOR116C RPO31
SGTC_1504 k297-0033 30 µM -0.709093023602138 0.227574903520775 no 2610 0.239133375976526 792 4388117
SGTC_2399 5884133 200 µM -0.709688342993719 0.227390659742579 no 2611 0.238948711240594 840 722445
SGTC_2062 5245942 200 µM -0.710302974198007 0.227200527399358 no 2612 0.238758137928392 841 1376160
SGTC_1121 fusaric acid 630.51 nM -0.713213871304054 0.226301277545477 no 2613 0.23785671201035 828 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_2326 6164455 177.58 µM -0.713435338496693 0.226232943120066 no 2614 0.23778820610618 844 2888790
SGTC_1741 st038134 10.228 µM -0.715216751549132 0.225683706526631 no 2615 0.237237559777809 836 1272587
SGTC_452 diindolylmethane 8 µM -0.717540627881661 0.224968355566104 no 2616 0.236520288552479 825 3071 Inhibits expression of several cancer promoting factors.
SGTC_2383 9036125 200 µM -0.717586716072707 0.22495418140322 no 2617 0.236506075376607 839 79580
SGTC_1963 st076565 50.3 µM -0.718425110049872 0.224696426439795 no 2618 0.236247604419291 868 4914280
SGTC_1323 1348-1351 11.2 µM -0.72062021447034 0.224022359848034 no 2619 0.235571606609855 826 6989654
SGTC_1348 1493-0373 93.8 µM -0.721561120190412 0.223733781233943 no 2620 0.235282175149499 860 3010129
SGTC_1635 st007035 42.4 µM -0.723854847636919 0.223031174411402 no 2621 0.234577426350219 829 3716403
SGTC_2373 9071805 200 µM -0.72506443199111 0.222661165253111 no 2622 0.234206251731004 867 10149009
SGTC_843 0310-0051 143 µM -0.727776060744828 0.221832956765142 no 2623 0.233375340568849 850 2065037
SGTC_1561 5-methoxyflavone 52.9 µM -0.727900209123193 0.221795080493278 no 2624 0.233337337582639 829 94525
SGTC_1329 1447-1697 50.6 µM -0.728421556026629 0.221636063761374 no 2625 0.233177785885815 842 2840515
SGTC_1526 st051518 75 µM -0.730036539368748 0.221143889188078 no 2626 0.232683925017203 849 673993
SGTC_1225 1216-0074 20.6 µM -0.730295812932028 0.221064932516149 no 2627 0.232604693522809 848 4241466
SGTC_1090 efavirenz 20.7 µM -0.730562990909242 0.2209835855902 no 2628 0.232523062209698 839 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_1060 3448-7350 82 µM -0.731790730095626 0.220609999630125 no 2629 0.23214815395792 854 570178
SGTC_294 k038-0071 157 µM -0.732789176738739 0.220306451528415 no 2630 0.231843511788151 854 24152826
SGTC_888 0916-0002 6.97 µM -0.732892318166153 0.220275108086739 no 2631 0.231812054370392 839 2802138 YIL048W NEO1
SGTC_3048 9093155 49.47 µM -0.733010311767205 0.220239254383535 no 2632 0.231776070059098 815 25236002
SGTC_2465 5809242 33.21 µM -0.733982111798886 0.219944089149016 no 2633 0.231479820217773 884 2731748
SGTC_347 4534-1311 26.2 µM -0.734443892738711 0.219803911826066 no 2634 0.231339121940684 852 2862016
SGTC_433 pimozide 108 µM -0.734643369476779 0.219743374920455 no 2635 0.231278358887802 848 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_2280 7785178 200 µM -0.736056292082918 0.219314857361537 no 2636 0.230848220344621 841 2954328
SGTC_2006 4011487 200 µM -0.736062225793009 0.219313058772349 no 2637 0.230846414877203 851 45595294
SGTC_491 tetrandrine 80.3 µM -0.739861668500236 0.21816313707529 no 2638 0.229691967607413 851 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_2354 9060492 162 µM -0.740121287840975 0.218084688924784 no 2639 0.22961320138497 861 6471895
SGTC_947 3447-0010 211 µM -0.740453316044469 0.217984384973154 no 2640 0.229512489004566 861 748350
SGTC_1749 st037932 54.2 µM -0.742147019641758 0.217473140214348 no 2641 0.228999132096059 890 594497
SGTC_146 3448-8650 53.125 µM -0.744093719891055 0.216886384231445 no 2642 0.228409889196095 869 2891488 YIL048W NEO1
SGTC_113 0099-0221 2.5 µM -0.746126018477524 0.216274805551122 no 2643 0.227795646714266 844 89219
SGTC_1396 3511-0007 98.6 µM -0.746283679828509 0.216227402360755 no 2644 0.227748033991408 840 X1396
SGTC_2742 clothiapine 36.27 µM -0.746535450120483 0.216151716416323 no 2645 0.227672012583904 837 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_688 0527-0193 473 µM -0.748474580476343 0.215569298950792 no 2646 0.22708697598641 878 4007154
SGTC_3195 9113082 49.47 µM -0.748723508996426 0.215494599281304 no 2647 0.227011935559927 839 17018038
SGTC_2427 5545055 42.75 µM -0.750065531990644 0.215092137300915 no 2648 0.226607618726444 845 5372858
SGTC_2521 angolensin 13.4 µM -0.751695362470664 0.214603951445217 no 2649 0.22611713996223 857 821428 A flavenoid.
SGTC_2281 7943571 200 µM -0.754372988100359 0.213803317512367 no 2650 0.225312643294305 851 1244024
SGTC_2183 6420625 130.508 µM -0.754428755505317 0.213786661073908 no 2651 0.225295905141928 859 2897619
SGTC_1198 1612-1005 86.7 µM -0.755516675444493 0.213461875666261 no 2652 0.224969515338069 873 6998509
SGTC_422 cantharidin 155 µM -0.757457434900439 0.212883199930186 no 2653 0.224387928837595 860 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2416 tofa 880 nM -0.75926337292391 0.212345547148763 no 2654 0.223847511561686 852 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2068 5226020 147 µM -0.75959364127503 0.212247307581267 no 2655 0.223748760599697 868 1810509
SGTC_801 0866-0028 10.1 µM -0.760418119358057 0.212002179432487 no 2656 0.223502347955696 845 6849771
SGTC_2049 5262831 67.185 µM -0.760743873523971 0.211905374096986 no 2657 0.223405032021101 867 763417
SGTC_1308 1187-1617 41.4 µM -0.762941699662573 0.211252915654903 no 2658 0.222749082918379 861 2882570
SGTC_1357 1503-1303 39.5 µM -0.763230846504647 0.211167165669209 no 2659 0.222662867778543 844 292895
SGTC_2907 7721985 69.9 µM -0.767433933534881 0.209922994402701 no 2660 0.221411779755997 848 3267881
SGTC_445 e6 berbamine 66 µM -0.767459082846732 0.209915562852165 no 2661 0.221404305945844 855 6610268 A calcium/calmodulin antagonist.
SGTC_366 0181-0206 4.31 µM -0.767765788306901 0.209824944697726 no 2662 0.221313171584716 870 274874
SGTC_1857 st056007 79.3 µM -0.768346358455246 0.209653474389183 no 2663 0.221140719913527 858 619834
SGTC_693 4161-2696 114 µM -0.768859898465653 0.209501870012806 no 2664 0.220988242874471 878 805759
SGTC_1045 1348-1485 165 µM -0.769442925189567 0.209329830359164 no 2665 0.220815207242616 853 6810614
SGTC_3235 9132602 49.47 µM -0.772400708868541 0.208458328623069 no 2666 0.219938567078774 854 4912240
SGTC_1068 loratadine 26.9 µM -0.774085419721734 0.207962891745159 no 2667 0.219440139535875 886 3957 A H1 histamine antagonist.
SGTC_2194 5927483 104.545 µM -0.774478924521143 0.207847270760879 no 2668 0.21932381333889 827 760979
SGTC_1078 idebenone 36.1 µM -0.775943622368888 0.207417241766497 no 2669 0.21889113723298 872 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_1391 3442-0225 151 µM -0.777150224716181 0.207063383922679 no 2670 0.218535072484571 851 5227075
SGTC_1478 0453-0656 35.7 µM -0.777598693075912 0.20693195360713 no 2671 0.218402815871878 871 5258496
SGTC_2482 5981709 142.65 µM -0.778388207047419 0.206700694809182 no 2672 0.218170094459641 884 877755
SGTC_2087 5276107 200 µM -0.779439241330644 0.206393070929181 no 2673 0.21786050777151 855 144405
SGTC_1028 k015-0029 4.8 µM -0.780287581889405 0.206144970796139 no 2674 0.217610810282266 864 4588309
SGTC_2549 cedrol 20.94 µM -0.781270025654758 0.205857872783916 no 2675 0.217321847821333 857 6708665 A sedative which affects the nervous system.
SGTC_1853 st056710 91.2 µM -0.781812269380947 0.205699515391344 no 2676 0.217162454676546 873 269167
SGTC_618 k072-0232 33.2 µM -0.781879670363406 0.205679836595056 no 2677 0.217142646803232 847 5872756 YGL099W LSG1
SGTC_615 k087-0205 167 µM -0.782350103459395 0.205542517237396 no 2678 0.217004424488358 865 9642773
SGTC_3062 9077494 49.47 µM -0.783235906906558 0.205284099116384 no 2679 0.216744296416783 793 16459633
SGTC_62 0180-0423 3.232 µM -0.783645790465556 0.20516458789198 no 2680 0.21662398965858 871 30102 YGL099W LSG1
SGTC_3182 9108849 49.47 µM -0.784458922564092 0.20492762243952 no 2681 0.21638543797572 857 17133045
SGTC_1659 st012954 42.1 µM -0.784505858815139 0.204913949102532 no 2682 0.216371672750827 868 24207262
SGTC_1745 st081495 74 µM -0.785270590540377 0.204691246027875 no 2683 0.216147467533511 849 13842402 YBL026W LSM2
SGTC_518 1021-0119 62.6 µM -0.786787686913633 0.204249867753462 no 2684 0.215703081320767 879 1097762
SGTC_2270 7924575 90.91 µM -0.786947863332413 0.204203299732929 no 2685 0.215656193552176 875 1262135
SGTC_2649 anisomycin 9.56 µM -0.787869079163996 0.203935597833342 no 2686 0.215386644669515 859 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_852 0418-0143 439 µM -0.788064215898973 0.20387891867563 no 2687 0.215329572519039 854 5369229
SGTC_1868 st057644 42.7 µM -0.78876675453368 0.203674937991199 no 2688 0.215124171888752 873 688665
SGTC_1911 st060208 74.3 µM -0.788959051474438 0.203619126179085 no 2689 0.215067970027759 887 688783
SGTC_2478 5763493 32.33 µM -0.789215359149383 0.203544750222814 no 2690 0.214993073260034 856 1365576 YLR208W SEC13
SGTC_1888 azatryptophan 97.5 µM -0.792244998143929 0.202666830898174 no 2691 0.214108917750035 863 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_120 rhodamine 6G 52.259 µM -0.792699822721034 0.202535228893584 no 2692 0.213976366812904 895 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_401 neomycin 50 µM -0.7930391818215 0.202437069733873 no 2693 0.21387749746293 839 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_276 colchicine 750 µM -0.794481841394622 0.202020100013716 no 2694 0.213457488028187 867 2833 A microtubule depolymerizer.
SGTC_3180 9109287 49.47 µM -0.794906710888873 0.201897398676284 no 2695 0.213333885126995 853 18891271
SGTC_2837 9008476 45.46 µM -0.796348866195315 0.201481240393057 no 2696 0.212914645080084 861 2992805
SGTC_3002 9075603 71.4286 µM -0.796986545836195 0.201297391169271 no 2697 0.212729422586466 871 20105405
SGTC_2438 5259590 200 µM -0.799165577031754 0.200669914756946 no 2698 0.21209720453907 855 1201127
SGTC_2682 pyrogallin 40.03 µM -0.800291881670475 0.200346043574697 no 2699 0.211770852801585 856 822798 An ATP competetive kinase inhibitor.
SGTC_1790 st045711 43.5 µM -0.800696710486478 0.200229710991819 no 2700 0.211653623693766 831 585119
SGTC_1859 st055998 20 µM -0.802213382498952 0.199794237518111 no 2701 0.211214768245111 871 676301
SGTC_3125 9127534 49.47 µM -0.802952389596423 0.199582257164008 no 2702 0.211001126753087 843 1639235
SGTC_2152 5568786 200 µM -0.803559783351665 0.199408130796091 no 2703 0.210825628592382 876 5399883
SGTC_2397 5161689 200 µM -0.803984255488728 0.199286498323574 no 2704 0.210703033977154 876 2259942
SGTC_2761 levamisole 97.89 µM -0.804242735511532 0.199212452776257 no 2705 0.210628401137609 863 26879 An alkaline phosphatase inhibitor.
SGTC_3005 9076496 71.4286 µM -0.804857398685395 0.199036439696151 no 2706 0.21045098722551 870 21368410
SGTC_270 tamoxifen 5.46 µM -0.805141467396179 0.198955126312542 no 2707 0.210369024418584 894 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_2222 6885208 172.143 µM -0.806031370977515 0.198700525060774 no 2708 0.210112380437445 869 609514
SGTC_3072 9116419 49.47 µM -0.806071339702689 0.198689094627788 no 2709 0.210100857963888 870 17170162
SGTC_2728 chlorpromazine 9.18 µM -0.806501249041832 0.198566172322629 no 2710 0.209976944057999 909 2726 A thorazine and dopamine antagonist.
SGTC_3332 9141069 11.198 µM -0.808301529261881 0.198051923632809 no 2711 0.209458511199356 874 17332883
SGTC_2794 7785382 27.27 µM -0.810153950178521 0.197523621376261 no 2712 0.208925850137055 860 2205081
SGTC_1511 0906-3109 28.5 µM -0.810556518737925 0.197408923401934 no 2713 0.208810197744339 869 2882180
SGTC_644 1498-1197 63.3 µM -0.811423523100253 0.197162037344624 no 2714 0.208561247499308 888 6741615
SGTC_777 1315-0167 517 µM -0.811718930023066 0.197077960676661 no 2715 0.208476464813694 856 4221767
SGTC_34 0469-0683 81.75 µM -0.813961418240963 0.196440427050239 no 2716 0.207833526900679 865 3690923
SGTC_11 0438-0307 1.3 µM -0.815891164980042 0.195892806840999 no 2717 0.207281192846246 890 4011476
SGTC_1265 0819-1001 68.8 µM -0.816157334351891 0.195817346516178 no 2718 0.207205077757518 884 3106768
SGTC_76 0433-0009 400.328 µM -0.81766526560628 0.195390173760631 no 2719 0.206774174605519 913 2841569
SGTC_1034 k072-0165 12.7 µM -0.81787517515825 0.195330754665387 no 2720 0.206714233402472 894 5835461
SGTC_1141 3253-0389 52.6 µM -0.820274401321376 0.194652385825023 no 2721 0.206029848032195 884 5402031
SGTC_1150 3909-7983 10.9 µM -0.821335304835929 0.194352878446619 no 2722 0.205727651569577 882 23965914
SGTC_3032 9089427 49.47 µM -0.82186684453223 0.19420292318264 no 2723 0.205576342406343 835 17173707
SGTC_2276 7947513 42.08 µM -0.822795238086077 0.193941178617445 no 2724 0.20531222254628 881 2105100
SGTC_3034 9090421 49.47 µM -0.823208373116435 0.19382477146668 no 2725 0.205194754075002 854 17173761
SGTC_40 0327-0103 19.753 µM -0.824558304645922 0.193444704528083 no 2726 0.204811200728434 872 409036
SGTC_560 2332-1943 155 µM -0.825066949328386 0.193301615997041 no 2727 0.204666791196992 869 21177716
SGTC_1803 st050068 52.4 µM -0.827766825000181 0.192543186840895 no 2728 0.203901282988368 891 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_1827 berberine 7.24 µM -0.828414466171432 0.192361527122025 no 2729 0.203717908362252 858 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2021 4019055 173 µM -0.829898723652684 0.191945596736671 no 2730 0.203298023295923 891 44827708 YER133W GLC7
SGTC_2546 rhodinyl acetate 100 µM -0.829978647242747 0.191923215544882 no 2731 0.20327542818821 876 6708682
SGTC_680 0417-1641 114 µM -0.830413915239034 0.191801354460244 no 2732 0.203152400374633 880 2835990
SGTC_2762 leflunomide 42.06 µM -0.831007118434434 0.191635352880205 no 2733 0.202984804013227 895 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_2426 5582046 32.21 µM -0.831396757097894 0.191526364558633 no 2734 0.20287476522324 882 2251934
SGTC_277 nystatin 15.5 µM -0.831871030754488 0.191393753696129 no 2735 0.202740872556189 896 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1472 k841-0093 193 µM -0.833337266724482 0.190984137908136 no 2736 0.202327272095785 887 X1472
SGTC_466 geldanamycin 89.2 µM -0.836731616343933 0.190037938928422 no 2737 0.201371721691793 858 5288382 HSP90 inhibitor.
SGTC_2883 9059145 45.46 µM -0.837091229878433 0.189937863181888 no 2738 0.201270644849772 904 16476510
SGTC_2635 hydroquinidine 100 µM -0.838941514385451 0.189423465543693 no 2739 0.200751065054871 879 442912 An experimental heart treatment.
SGTC_3303 9125618 40.5795 µM -0.839445566794455 0.189283482655961 no 2740 0.200609661369981 872 22695467
SGTC_443 clozapine 122 µM -0.840534828654891 0.188981195942733 no 2741 0.200304291039101 893 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_1633 st005664 67.9 µM -0.84123858418845 0.188786051321823 no 2742 0.200107144505698 904 2063822
SGTC_1515 3460-0031 42.1 µM -0.841688236629378 0.188661432084402 no 2743 0.199981242224545 874 2876596
SGTC_128 0906-2981 13.371 µM -0.841769062621592 0.188639036886906 no 2744 0.199958616070257 880 6740226
SGTC_2188 6126565 140.678 µM -0.841846120526981 0.188617687273846 no 2745 0.199937046174807 864 874518
SGTC_3208 9114115 49.47 µM -0.843664797921188 0.188114238255956 no 2746 0.199428371913146 871 650895
SGTC_1612 st002233 45.4 µM -0.844056781010169 0.188005837644596 no 2747 0.199318838499796 875 1035021
SGTC_879 0831-1030 162 µM -0.844447443851476 0.187897840515546 no 2748 0.199209710059502 892 1549252
SGTC_1893 st059353 36.1 µM -0.845072332631035 0.187725172253789 no 2749 0.199035227374749 918 3112488
SGTC_469 w7 172 µM -0.845482297745008 0.187611944615191 no 2750 0.198920806141938 872 45115570 A P450 inhibitor.
SGTC_2931 9014674 55.67 µM -0.84571434821583 0.187547873655368 no 2751 0.198856058447106 900 2996810
SGTC_1651 st011928 86.1 µM -0.848185161732049 0.18686650132048 no 2752 0.198167429777027 900 720198
SGTC_1558 st069300 45.6 µM -0.849908797193142 0.186392085380934 no 2753 0.197687897107275 867 24208000
SGTC_1782 st039423 80.636 µM -0.850359151551858 0.186268252238172 no 2754 0.197562719659361 896 2068169
SGTC_2831 7999036 19.48 µM -0.850476651342971 0.186235951915269 no 2755 0.197530068096591 902 2988270
SGTC_715 0868-0130 184 µM -0.851212814780947 0.186033661905876 no 2756 0.197325572746514 923 2876258
SGTC_2688 kanamycin b 96.69 µM -0.852119501608103 0.185784701137681 no 2757 0.197073884566333 866 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_1120 ficusin 1.78878 µM -0.852337303396208 0.185724927272482 no 2758 0.197013453684582 903 6199 A DNA cross-linker.
SGTC_3091 9116372 49.47 µM -0.852542061154442 0.185668744112664 no 2759 0.196956652205042 896 17169793
SGTC_210 3551-0445 56.827 µM -0.853636025067043 0.185368751771368 no 2760 0.196653345660797 885 2865180 YOR207C RET1
SGTC_1940 st075990 51.1 µM -0.853869965579982 0.185304638493008 no 2761 0.196588521314808 922 1084979
SGTC_2517 totarol 10 µM -0.854231546231583 0.185205571498688 no 2762 0.196488353669255 869 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_1387 3342-1166 1.8 µM -0.855453588460339 0.184870996063404 no 2763 0.196150043803269 868 3418228
SGTC_2552 juarezic acid 87.02 µM -0.858567300796845 0.184020211167914 no 2764 0.195289642528436 887 1549512
SGTC_792 4534-1957 155 µM -0.859493990306022 0.18376747573472 no 2765 0.19503401710064 879 1717904
SGTC_2669 eugenol 100 µM -0.859840203303141 0.183673108796149 no 2766 0.194938567163549 866 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_1494 4358-1428 177 µM -0.860265430523584 0.1835572463519 no 2767 0.194821372106221 891 1564571
SGTC_3154 9100113 49.47 µM -0.860652282333377 0.183451879704861 no 2768 0.194714790766953 897 25237525
SGTC_324 1315-0088 19.6 µM -0.86098775062088 0.18336053889414 no 2769 0.194622394798701 913 6787421
SGTC_2589 lobaric acid 100 µM -0.861153625050876 0.183315385327211 no 2770 0.194576718882643 915 73157 A novel microtubule depolymerizer.
SGTC_2604 4'-hydroxychalcone 11.32 µM -0.866830122007897 0.181774336227069 no 2771 0.193017547590366 905 5282362
SGTC_245 methotrexate 289.6 µM -0.867979849538994 0.181463199262357 no 2772 0.192702681949063 872 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_895 0964-0006 13.7 µM -0.868604619036081 0.181294265277639 no 2773 0.192531713584337 903 6738897
SGTC_1188 1403-0014 4.57 µM -0.869279703601685 0.181111837135054 no 2774 0.192347080747424 871 9614867
SGTC_868 0527-0199 213 µM -0.869900615433085 0.180944149657185 no 2775 0.192177359557138 893 2849450
SGTC_2272 7805186 180 µM -0.871236440363602 0.180583718066921 no 2776 0.191812533394499 922 2956062 YPR165W RHO1
SGTC_415 dibenzyl ketone 100 µM -0.871300984367676 0.180566314248364 no 2777 0.191794916574859 894 7593
SGTC_3006 9075424 71.4286 µM -0.871677278069838 0.180464870349417 no 2778 0.191692229652176 894 7465181
SGTC_1459 k035-0031 35.7 µM -0.871813698798454 0.18042810192315 no 2779 0.191655010068282 875 3877128 YMR208W ERG12
SGTC_845 0330-0138 4.51 µM -0.872762870597934 0.180172409093097 no 2780 0.191396170654253 896 9039800
SGTC_2210 7115885 190.385 µM -0.874295320397558 0.179760070119883 no 2781 0.190978723561062 903 2927039
SGTC_2159 5658611 73.75 µM -0.87442461958673 0.179725306500266 no 2782 0.190943527372301 909 793844
SGTC_820 1582-0060 59.9 µM -0.875285953945095 0.179493834349525 no 2783 0.190709167385247 900 3848840
SGTC_995 3931-2021 34.6 µM -0.876221622947422 0.179242598203171 no 2784 0.190454781869917 907 730143
SGTC_3129 9127257 49.47 µM -0.877362936488463 0.178936444087434 no 2785 0.190144768876632 900 837894
SGTC_1438 4092-1045 4 µM -0.87745488133088 0.178911794476344 no 2786 0.19011980756408 881 1351342
SGTC_640 3381-0960 37.1 µM -0.878787418283392 0.178554792878719 no 2787 0.189758274695453 906 1745025
SGTC_2460 5552655 174.22 µM -0.879883602475914 0.178261449429584 no 2788 0.189461184287076 894 5401989
SGTC_2005 4024620 188 µM -0.881296658749341 0.177883758065899 no 2789 0.189078637040371 897 236743
SGTC_2507 purpurin 79.67 µM -0.881404673025853 0.177854908049177 no 2790 0.189049414645094 908 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_1086 cerivastatin 2.18 µM -0.88291740137833 0.177451176792545 no 2791 0.188640450473078 864 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_1796 st049173 110.4 µM -0.883052055452536 0.177415267101585 no 2792 0.188604073370455 898 94134
SGTC_319 1348-1596 45.5 µM -0.884808502717839 0.17694727616895 no 2793 0.188129961400089 890 5380505
SGTC_2826 7992541 19.48 µM -0.885569095780431 0.176744864667714 no 2794 0.187924885463917 939 2985066
SGTC_223 busulfan 5 mM -0.887367821068589 0.176266764729372 no 2795 0.187440451175845 883 2478 A DNA alkylator.
SGTC_2216 7189485 200 µM -0.887913882595667 0.176121784044765 no 2796 0.187293538263294 875 731273
SGTC_1555 citronellol 128 µM -0.887958954338905 0.176109820758898 no 2797 0.18728141530009 892 8842 A terpine precursor.
SGTC_3333 9141820 12.094 µM -0.888822783971532 0.175880635922354 no 2798 0.187049164492033 891 1939433
SGTC_2455 5377712 9.75 µM -0.888830486880738 0.175878593093999 no 2799 0.187047094275619 859 2243908
SGTC_2718 lomofungin 53.02 µM -0.889562862958478 0.175684433995799 no 2800 0.186850327283377 900 5351222 A RNA synthesis inhibitor.
SGTC_2906 7926292 26.41 µM -0.890499504265309 0.175436320436596 no 2801 0.186598867239908 911 2966319
SGTC_1389 3405-0187 19 µM -0.892040769911883 0.175028527393317 no 2802 0.186185540084135 884 799890
SGTC_1766 st045414 44.774 µM -0.89302434637711 0.174768604161494 no 2803 0.185922067410351 891 253960
SGTC_2566 crystal violet carbinol 226 nM -0.895102842476167 0.174220140234743 no 2804 0.185366057311702 920 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_3309 9129340 25.759 µM -0.895860161949939 0.17402057445377 no 2805 0.185163726691683 881 17158987
SGTC_2813 7971799 71.43 µM -0.897447669973731 0.17360271257452 no 2806 0.184740042600816 913 2234054
SGTC_3022 9087993 49.47 µM -0.898069019791836 0.173439335645751 no 2807 0.184574377103611 914 17173644
SGTC_656 4090-1979 187 µM -0.899868174307008 0.172966820429317 no 2808 0.184095204300018 890 22330961
SGTC_2962 9082311 13.18 µM -0.902126175629483 0.172374959247748 no 2809 0.183494922745574 904 16459453
SGTC_907 3448-6986 75.5 µM -0.902853682454302 0.172184542634723 no 2810 0.183301777821918 917 590582
SGTC_1559 coumarin 343 70.1 µM -0.905591957730755 0.171469034364384 no 2811 0.182575933546123 904 108770 A hepatotoxic, DNA x-linker.
SGTC_3196 9111891 49.47 µM -0.906368851637366 0.171266379385808 no 2812 0.182370326868006 921 18891510
SGTC_1228 0124-0032 52.5 µM -0.908139225712583 0.170805144631961 no 2813 0.181902334193272 894 X1228
SGTC_3337 9144342 33.5465 µM -0.909820913826301 0.170367752086176 no 2814 0.181458481622185 885 17682949
SGTC_1947 st076332 61.6 µM -0.911453637579056 0.169943781776745 no 2815 0.181028201588844 912 24208416
SGTC_3297 9117502 71.43 µM -0.913191478053341 0.169493259520293 no 2816 0.18057092257617 894 7453720
SGTC_2769 toremifene 3.73 µM -0.914780383080095 0.169082018967502 no 2817 0.180153467596897 916 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_1009 4106-0057 9.87 µM -0.915374839505772 0.168928326549042 no 2818 0.17999744117489 883 2928005
SGTC_2853 9015042 58.44 µM -0.915733988467027 0.168835514680515 no 2819 0.179903216813679 895 6457456
SGTC_1720 st037298 9.481 µM -0.917586236177101 0.168357374094914 no 2820 0.179417763208527 927 597396
SGTC_3280 9140961 49.47 µM -0.918020667393718 0.168245355905059 no 2821 0.179304022939745 931 4901226
SGTC_2339 9000433 200 µM -0.918723066516905 0.168064343580612 no 2822 0.179120220806797 912 2988954
SGTC_1179 1021-1431 9.29 µM -0.918989483045431 0.167995719291792 no 2823 0.17905053657795 932 2840958
SGTC_168 3970-0862 530.542 µM -0.920390919413968 0.16763503052775 no 2824 0.178684256094462 898 3135186
SGTC_467 ro 31-8220 72.8 µM -0.92150274653587 0.167349233804449 no 2825 0.178394003975449 909 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_521 r062-0005 13.8 µM -0.921713117602293 0.167295192974675 no 2826 0.178339118221129 907 2832033
SGTC_2419 paclitaxel 166.5 µM -0.92230575054123 0.167143015904324 no 2827 0.178184557662666 914 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_3055 9094636 49.47 µM -0.924394303658384 0.166607426190953 no 2828 0.177640529714685 917 25236176
SGTC_2827 7993847 71.43 µM -0.92529423875036 0.166376988189521 no 2829 0.177406437377794 868 2985692
SGTC_2462 5162487 171.77 µM -0.926878388582341 0.165971849930448 no 2830 0.176994839568913 918 2259986
SGTC_462 ag-879 158 µM -0.93110543878674 0.164893926409135 no 2831 0.175899512758692 923 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_2721 ifenprodil 61.44 µM -0.931284087929766 0.164848469869797 no 2832 0.175853315363726 914 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_373 0844-0104 25.9 µM -0.931321841900895 0.16483886456613 no 2833 0.175843553439589 899 5375804
SGTC_2012 4023501 200 µM -0.932553964845616 0.164525588829995 no 2834 0.17552515572934 914 3477460
SGTC_1119 parthenolide 318.541 nM -0.936432944501292 0.163541852968405 no 2835 0.17452516120668 953 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_174 3553-0389 74.3 µM -0.937034026863005 0.163389756860953 no 2836 0.174370527580081 904 738071
SGTC_2569 tetrandrine 100 µM -0.937998342072128 0.163145941396149 no 2837 0.1741226310639 910 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_2815 7968870 71.43 µM -0.939639473610509 0.162731544997045 no 2838 0.173701260676076 935 2977326 YHR190W ERG9
SGTC_3151 9099821 49.47 µM -0.939811882712041 0.162688050350572 no 2839 0.173657031288675 914 17174189
SGTC_1518 st038567 90.8 µM -0.940927567728465 0.162406772822361 no 2840 0.173370989558324 929 77966
SGTC_1693 xanthone 101.9 µM -0.941494340181134 0.1622640040209 no 2841 0.17322579417008 919 7020 An insecticide.
SGTC_1606 st000094 49.2 µM -0.945234935098911 0.161323805756391 no 2842 0.172269473840666 898 1242210
SGTC_463 ikarugamyin 104 µM -0.945640569598071 0.161222063531441 no 2843 0.172165972175613 947 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_2874 9043904 71.43 µM -0.948183261991458 0.160585253113442 no 2844 0.171518083330173 916 4463428
SGTC_1428 4049-0204 61.7 µM -0.948490319681626 0.160508462683684 no 2845 0.171439949292954 926 X1428
SGTC_315 k915-0449 187 µM -0.949158539717845 0.160341433999134 no 2846 0.171269992358099 901 20970215 YNL149C PGA2
SGTC_2641 levomentholum 100 µM -0.950795221501711 0.159932808030424 no 2847 0.170854169400194 898 16666
SGTC_2924 9010168 62.78 µM -0.955860865394544 0.158672402372822 no 2848 0.169571266442611 929 2993929
SGTC_46 0329-0187a 2.197 µM -0.956597060488465 0.158489769859305 no 2849 0.169385336545216 900 46494817
SGTC_2800 7887935 81.82 µM -0.958813489928742 0.157940759101374 no 2850 0.168826356054288 943 2961002
SGTC_1878 temozolomide 1 mM -0.958862511199844 0.157928630637559 no 2851 0.168814006368517 891 5394 DNA alkylating agent.
SGTC_2495 cafestol 54.53 µM -0.959807115929544 0.157695043269614 no 2852 0.168576150145509 921 16667697 An anti-infammatory.
SGTC_1098 clofazimine 15.1 µM -0.961884704818605 0.157182083915341 no 2853 0.16805376124344 930 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_2849 9019321 12.99 µM -0.969278426846083 0.15536547470141 no 2854 0.166203144981784 917 16489627
SGTC_1175 0741-0056 27.6 µM -0.972523921754237 0.154572462079719 no 2855 0.16539498500655 922 765927
SGTC_1673 st016611 27.3 µM -0.972602044459359 0.154553406406894 no 2856 0.165375563076902 945 5226799
SGTC_1354 1498-1681 81 µM -0.97636830964189 0.153636581616046 no 2857 0.1644409899479 934 5754243
SGTC_1349 flufenamic acid 69 µM -0.977385263280531 0.153389642537034 no 2858 0.16418922796082 924 3371 A non-steroidal anti-inflammatory.
SGTC_543 3844-1095 191 µM -0.977465937028063 0.153370064409881 no 2859 0.164169266683201 935 4230703
SGTC_1404 3909-7820 48.3 µM -0.980077068685731 0.15273728169088 no 2860 0.163524038762942 893 23741373
SGTC_3174 9107204 49.47 µM -0.981536973329867 0.152384243617372 no 2861 0.163164005416011 940 3938802
SGTC_1143 3454-2408 5.08 µM -0.982319525164983 0.152195227970741 no 2862 0.162971229186102 882 X1143
SGTC_1321 1326-2144 215 µM -0.984725248070205 0.151615130825627 no 2863 0.162379523690125 938 3513030
SGTC_1209 2323-2347 50.3 µM -0.985729996717957 0.151373289285161 no 2864 0.162132812737504 894 5412760
SGTC_1643 st009866 20.2 µM -0.988387979331775 0.150734754341312 no 2865 0.16148133616638 895 3156273 YOR207C RET1
SGTC_2064 5220758 200 µM -0.988522650278208 0.150702449751695 no 2866 0.161448373556627 924 788518
SGTC_2093 5331342 194.4 µM -0.995225644872756 0.149100373892898 no 2867 0.159813265887054 916 33839
SGTC_2408 sulbentine 18.36 µM -0.996528301989226 0.148790352211336 no 2868 0.159496761410217 905 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_988 1497-1057 103 µM -0.996579593626095 0.148778154045507 no 2869 0.159484307566641 924 3533044
SGTC_2156 5649887 115 µM -1.00024331523893 0.147908577345823 no 2870 0.158596385929419 945 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_2871 9038510 12.99 µM -1.00293258468384 0.147272454465493 no 2871 0.157946694769823 918 4945164
SGTC_172 1112-0046 2.638 µM -1.00706747343488 0.146297965272734 no 2872 0.15695117533339 962 2802135 YIL048W NEO1
SGTC_2203 7227154 166.4 µM -1.00913006630604 0.145813486345105 no 2873 0.156456130143848 934 896304
SGTC_1957 st077035 62.4 µM -1.01277372080669 0.144960272306791 no 2874 0.155584127850312 940 705593
SGTC_2941 9056145 11.23 µM -1.0129475411942 0.144919653931002 no 2875 0.155542609286488 921 2119517
SGTC_381 3461-2219 42.7 µM -1.01319064170825 0.144862859017838 no 2876 0.155484554801223 959 2883159
SGTC_1462 k081-0014 26.5 µM -1.01579037468026 0.144256427621768 no 2877 0.154864610278181 865 3270634
SGTC_64 000l-0018 272.079 µM -1.01687787195769 0.144003258996382 no 2878 0.154605765595059 926 6811119
SGTC_355 1311-2252 105 µM -1.02208520940337 0.142795148756316 no 2879 0.153370286428937 953 5338538
SGTC_456 gingerol 170 µM -1.02454655046533 0.142226505161439 no 2880 0.152788597736932 937 442793 A herb.
SGTC_2228 7354201 200 µM -1.02863631380348 0.141285039690757 no 2881 0.151825303503081 956 753451
SGTC_1042 0350-0096 82 µM -1.02870814930476 0.141268540965774 no 2882 0.151808419662474 936 3122515
SGTC_1274 0865-0114 173 µM -1.03043176805653 0.140873062695961 no 2883 0.151403683416915 919 870624
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -1.03194991995789 0.140525350762915 no 2884 0.151047789317083 918 5379071
SGTC_2244 6635614 200 µM -1.03250954252716 0.140397323956249 no 2885 0.15091673984103 950 836499
SGTC_1679 SEC14.276 6.7 µM -1.03280946376376 0.140328742536206 no 2886 0.150846537017053 928 1005053 YMR079W SEC14
SGTC_1070 indatraline 8.81 µM -1.03365284198401 0.140136013600828 no 2887 0.150649243278195 932 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_1596 piperlongumine 63 µM -1.03523082941656 0.139775894813431 no 2888 0.150280562173471 934 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_1604 st002052 72.4 µM -1.0363822380225 0.139513524605878 no 2889 0.150011926730539 934 6254834 YHR062C RPP1
SGTC_2265 7929201 200 µM -1.03680023683502 0.139418358604303 no 2890 0.149914482583571 934 1265108
SGTC_1147 3809-1045 12.3 µM -1.03778985905353 0.139193226878282 no 2891 0.149683949533946 927 325925
SGTC_2725 haloperidol 53.21 µM -1.03850847826359 0.139029901467763 no 2892 0.149516695097044 927 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2921 7974240 10.71 µM -1.04503923815637 0.137551592280017 no 2893 0.148002417428909 940 2979074 YDR527W RBA50
SGTC_1549 4'-methoxyflavonol 74.6 µM -1.04578198455386 0.13738414558717 no 2894 0.14783085032614 944 97141
SGTC_1986 st071812 45 µM -1.04620347528626 0.137289185542578 no 2895 0.147733549365513 951 11838594
SGTC_599 1935-0052 86.5 µM -1.0465666554516 0.137207398579017 no 2896 0.147649743780752 938 9557311
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -1.04743696481915 0.137011543263543 no 2897 0.147449045273526 946 616764
SGTC_1773 st048542 73.5835 µM -1.04883528572071 0.13669726389868 no 2898 0.147126967114477 939 3237138
SGTC_3341 9147222 25.867 µM -1.04987523252376 0.136463850671281 no 2899 0.146887740069173 943 1939759
SGTC_2779 methotrexate 400 µM -1.05036452394856 0.136354124904385 no 2900 0.146775274866841 928 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_1485 3909-9022 254 µM -1.05114498770136 0.136179227410843 no 2901 0.146596002367871 964 714516
SGTC_2639 lactacystin 53 µM -1.0524958040726 0.135876880087668 no 2902 0.14628606730207 914 3870 A proteasome inhibitor.
SGTC_2299 7976368 114.88 µM -1.05315803961517 0.135728822837137 no 2903 0.146134282991721 949 2979718
SGTC_2780 5215298 71.43 µM -1.05588295139291 0.135120772186874 no 2904 0.145510847003154 958 2834131
SGTC_3036 9090181 49.47 µM -1.05757627172308 0.13474385850613 no 2905 0.145124332528621 949 25236586
SGTC_32 0928-0142 34.1 µM -1.05785427071614 0.134682048130345 no 2906 0.145060943033141 923 2244242
SGTC_2214 7179297 48.276 µM -1.05822643936571 0.134599330512076 no 2907 0.144976110095613 945 769744
SGTC_112 phenothiazine 287.218 µM -1.0608507649897 0.134017041910504 no 2908 0.144378863722163 943 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_1733 st037357 54.9 µM -1.06319175182123 0.133499083505423 no 2909 0.143847501063207 952 1272339 YGL099W LSG1
SGTC_2658 polymyxin b sulfate 77.05 µM -1.06997196969298 0.132006692053051 no 2910 0.142315962949626 950 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_129 0088-0017 176.636 µM -1.07010950239679 0.131976539313466 no 2911 0.142285011197371 948 182446
SGTC_3176 9106582 49.47 µM -1.07244211210988 0.131465860205652 no 2912 0.141760750779797 915 17018027
SGTC_471 1-acyl-paf 4 µM -1.07468426661732 0.130976271870085 no 2913 0.141258055061006 934 16759367
SGTC_3350 9150499 3.57 µM -1.07489503006946 0.130930315225692 no 2914 0.141210863669262 964 4910996 YPR165W RHO1
SGTC_1839 st053978 48 µM -1.0754851975843 0.130801689402388 no 2915 0.141078777963405 966 3788398
SGTC_2798 7813637 45.45 µM -1.07705940260113 0.13045902187022 no 2916 0.140726864211074 945 956368
SGTC_3245 9134821 49.47 µM -1.07769403962747 0.130321052025202 no 2917 0.140585159641659 955 17014901
SGTC_690 glyoxal 20.3 µM -1.07924624947689 0.129984027669161 no 2918 0.14023898359166 948 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_1163 k060-0048 49.9 µM -1.08330675104734 0.129105244337311 no 2919 0.139336144871961 944 6809982
SGTC_1470 k295-0292 231 µM -1.08407162125201 0.128940171453598 no 2920 0.139166522182384 968 5045612
SGTC_2485 5633444 17.78 µM -1.08488555153948 0.128764671338585 no 2921 0.138986174007059 945 5724239
SGTC_3089 9117425 49.47 µM -1.08924002445454 0.127828572616758 no 2922 0.138024026560325 959 9401657
SGTC_1753 st043925 64 µM -1.08948247536411 0.127776591311013 no 2923 0.137970589380454 961 670181
SGTC_2388 9080168 200 µM -1.0897841730044 0.127711928064923 no 2924 0.137904113684819 942 15943073
SGTC_1702 st027038 51 µM -1.09093554524818 0.127465362019583 no 2925 0.137650622529673 955 5521182
SGTC_1148 3909-7663 27.7 µM -1.09094181464278 0.127464020337274 no 2926 0.137649243103411 980 4084526
SGTC_1554 st069299 38.7 µM -1.09394554406153 0.126822336190917 no 2927 0.136989431147979 953 24207999
SGTC_1180 1193-0155 285 µM -1.09452362592854 0.126699099580694 no 2928 0.136862695639664 977 2921347
SGTC_1409 3909-8004 61.9 µM -1.09557388301454 0.12647541718032 no 2929 0.136632648131322 946 2119279
SGTC_3122 9126309 49.47 µM -1.10048682488906 0.125432719304681 no 2930 0.135560033480435 980 17591206
SGTC_2458 5808907 16.39 µM -1.10084490529131 0.125356957415636 no 2931 0.135482082019044 954 2731747
SGTC_2916 7875993 68.79 µM -1.10200445616693 0.125111841341633 no 2932 0.135229867157852 932 1299250
SGTC_654 1124-0271 80.9 µM -1.10279262681374 0.124945422094807 no 2933 0.135058615386029 952 5403748
SGTC_1464 k208-0027 110 µM -1.10341966016569 0.124813136875153 no 2934 0.134922481396131 923 X1464
SGTC_1317 1273-0028 910 nM -1.10511996204294 0.124454916809872 no 2935 0.134553805962065 937 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_36 0335-0881 14.2 µM -1.10671351044717 0.124119840750554 no 2936 0.134208906111704 922 23828853
SGTC_1572 epiandrosterone 68.9 µM -1.10955141053735 0.123524678334234 no 2937 0.13359618956775 952 441302 A steroid.
SGTC_1729 st035615 45.989 µM -1.11154034063467 0.123108754443279 no 2938 0.133167917970234 940 17385451
SGTC_2287 7945887 168.79 µM -1.11168370890894 0.123078811328629 no 2939 0.13313708336874 934 1245853
SGTC_2367 9070478 135.38 µM -1.11321392295004 0.122759537183259 no 2940 0.132808282203634 945 572802
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -1.11789836586003 0.121785756122506 no 2941 0.131805201534106 970 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1648 st011736 69.8 µM -1.11930458267593 0.121494500036604 no 2942 0.131505110724819 967 2855514
SGTC_318 1488-0629 67.2 µM -1.11932335301873 0.121490615631475 no 2943 0.131501108270706 976 3662576
SGTC_85 0868-0259 160.055 µM -1.12073759444611 0.121198198259032 no 2944 0.131199787334623 933 83173
SGTC_1379 2144-0755 36.5 µM -1.12172721456375 0.120993872850953 no 2945 0.13098922082261 959 5392327
SGTC_244 nsc-207895 1.295 µM -1.12179794865316 0.120979277773989 no 2946 0.130974179316577 921 42640
SGTC_3215 9129942 49.47 µM -1.12215990515722 0.120904612054876 no 2947 0.1308972284469 973 17682944
SGTC_3056 9094900 49.47 µM -1.12227096915714 0.120881707867577 no 2948 0.130873622838351 960 25236784
SGTC_778 3456-2434 196 µM -1.12281417714357 0.120769728721834 no 2949 0.130758211473158 873 5539063
SGTC_511 blebbistatin 171 µM -1.12356472801507 0.120615127222772 no 2950 0.130598863291151 969 3476986 A myosin inhibitor.
SGTC_25 0118-0223 35.662 µM -1.12597267084361 0.12012007025882 no 2951 0.13008854364779 961 5333628
SGTC_3330 9141424 71.43 µM -1.1287492246021 0.119551008902065 no 2952 0.129501818790471 943 27261020
SGTC_1710 st031758 61.5 µM -1.12879158221362 0.119542342360208 no 2953 0.129492882252263 957 5394341
SGTC_206 4546-0025 72.014 µM -1.13039354814877 0.119214898819968 no 2954 0.129155215767086 962 6620745 YIL048W NEO1
SGTC_3099 9120367 49.47 µM -1.13155195335293 0.118978514314968 no 2955 0.128911424763617 970 24824940
SGTC_705 1124-0212 310 µM -1.13198181684418 0.118890880499441 no 2956 0.128821039519623 936 9554485
SGTC_1864 st057645 30.4 µM -1.13260967969308 0.118762963619782 no 2957 0.128689100955647 961 688666
SGTC_2528 xanthyletin 44.79 µM -1.13317893129008 0.118647071892378 no 2958 0.12856955997734 978 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_2254 7938975 95.19 µM -1.13370006198876 0.118541046991157 no 2959 0.128460191818472 976 2969277
SGTC_2942 9052777 62.25 µM -1.1351133038243 0.118253857655259 no 2960 0.128163924026477 979 6469503
SGTC_3242 9133940 49.47 µM -1.13571621401538 0.11813148819698 no 2961 0.128037676259262 968 17248444
SGTC_1217 1183-1422 255 µM -1.13735565893508 0.117799191751449 no 2962 0.127694817859947 947 2849664
SGTC_2625 euphol 100 µM -1.13782224947953 0.117704740295874 no 2963 0.127597356182423 932 6708538 A triterpene alcohol.
SGTC_3224 9130643 49.47 µM -1.13803953196268 0.117660774317488 no 2964 0.127551987757175 974 17644395
SGTC_1941 st076221 61.8 µM -1.14167322892438 0.116927236808924 no 2965 0.126794936317481 905 2828568
SGTC_2425 5628681 7.85 µM -1.14253730232327 0.116753283601673 no 2966 0.12661537495981 963 5714958
SGTC_1037 k284-1091 78.7 µM -1.14257871710604 0.116744950685904 no 2967 0.126606773086958 959 3334711
SGTC_1833 st055984 71 µM -1.14288449599308 0.116683439092519 no 2968 0.126543275242799 958 676288
SGTC_566 0958-0068 16.5 µM -1.15006981571245 0.115244624019382 no 2969 0.125057558627 944 6815365
SGTC_814 3342-0569 96 µM -1.15116795906472 0.115025843611798 no 2970 0.124831572018695 952 4346283
SGTC_2044 5102272 200 µM -1.1529919749492 0.114663102435466 no 2971 0.124456839208388 964 592666
SGTC_100 0086-0128 49.5915 µM -1.1546323337327 0.114337580914629 no 2972 0.124120509979702 965 93297
SGTC_506 n9-isopropylolomoucine 153 µM -1.15483477634969 0.114297452784809 no 2973 0.124079046495164 961 6610355
SGTC_2234 tolnaftate 200 µM -1.15599267863053 0.114068126367708 no 2974 0.123842075840592 991 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_515 4092-1064 102 µM -1.159149816005 0.113444510520081 no 2975 0.123197561538231 995 717353
SGTC_831 k061-1017 217 µM -1.16256636547572 0.112772397555765 no 2976 0.122502741915327 997 1240153
SGTC_1253 0550-0034 176 µM -1.16259014467425 0.112767729631141 no 2977 0.122497915622924 960 5969915
SGTC_1563 conessine 56.1 µM -1.16278003714709 0.112730458145692 no 2978 0.122459379304337 968 441082 An anti-amoebic, histamine inhibitor.
SGTC_3254 9136651 49.47 µM -1.16384294965869 0.11252199550193 no 2979 0.122243831494625 977 16454030
SGTC_3312 9133330 71.43 µM -1.1642386363964 0.112444462217678 no 2980 0.122163658332903 983 17617324
SGTC_2381 9035592 200 µM -1.16497460162889 0.112300354209337 no 2981 0.122014636911196 976 4749657
SGTC_830 4076-0286 57.8 µM -1.16673273006236 0.11195663263101 no 2982 0.12165916036955 960 6866659
SGTC_2149 5554786 194.827 µM -1.16835846052262 0.111639465419023 no 2983 0.121331101636669 982 745063 YPR165W RHO1
SGTC_1257 0669-0121 16 µM -1.17548163506517 0.110257369314555 no 2984 0.119901040143202 954 4307855
SGTC_2098 5376439 882.5 nM -1.18150668983128 0.109097953990802 no 2985 0.11870074872162 964 2844116
SGTC_1049 3226-0134 66 µM -1.18286996213972 0.108836836291712 no 2986 0.11843034392679 966 5702385
SGTC_896 0964-0007 44.5 µM -1.18418636039937 0.108585123452506 no 2987 0.118169650075185 941 6756758
SGTC_3234 9132280 49.47 µM -1.18548675261017 0.108336882589965 no 2988 0.117912524686148 965 17612295
SGTC_3102 9121669 49.47 µM -1.18677926812935 0.108090550316986 no 2989 0.117657349235739 993 41905072
SGTC_2297 7971671 152.32 µM -1.18681822556182 0.108083131934136 no 2990 0.117649664120217 983 909016
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -1.18714873998045 0.10802020920379 no 2991 0.117584477980877 961 6312947
SGTC_2202 7226349 200 µM -1.18718403833841 0.108013490726165 no 2992 0.117577517727383 971 844334
SGTC_2852 9023854 51.95 µM -1.19076413897238 0.107333637865723 no 2993 0.116873095321199 968 19798528
SGTC_1901 st060216 58.6 µM -1.19131511636751 0.107229283040582 no 2994 0.116764950901001 962 688792
SGTC_2782 7736369 71.43 µM -1.19255116139272 0.106995442955943 no 2995 0.116522601314686 976 2950836 YOL077C BRX1
SGTC_323 4013-0906 34.3 µM -1.19312982444425 0.106886095600597 no 2996 0.116409266362699 950 2910086
SGTC_2752 diclazuril 33.15 µM -1.19431856100188 0.106661718379882 no 2997 0.11617668989286 941 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_2154 5570129 200 µM -1.19448955335883 0.106629471100892 no 2998 0.116143262363236 1003 673366
SGTC_1512 0259-0544 12.2 µM -1.19483390775597 0.106564551003541 no 2999 0.116075964768608 954 18476
SGTC_2197 6588183 93.1375 µM -1.19541238753815 0.106455556187531 no 3000 0.115962974081416 957 884136
SGTC_2646 retinol 96.75 µM -1.19543811282324 0.106450711003582 no 3001 0.115957951143193 948 445354 A vitamin A analog and teratogen.
SGTC_2539 epi(13)torulosol 80 µM -1.19725154160686 0.106109565026649 no 3002 0.115604262940768 961 6708597
SGTC_750 4073-0104 132 µM -1.1988497402785 0.105809563980278 no 3003 0.115293188797119 918 22330957
SGTC_719 2810-4230 27.3 µM -1.1989610136965 0.105788699478403 no 3004 0.115271552662558 979 721079
SGTC_3066 9117245 49.47 µM -1.19920195315472 0.10574353192838 no 3005 0.115224714001301 957 17176980
SGTC_1815 st051655 58.2 µM -1.19944421726036 0.105698130112379 no 3006 0.115177631471586 971 5984156
SGTC_3217 9129673 49.47 µM -1.20058663398103 0.105484223960579 no 3007 0.114955794176583 984 17248312
SGTC_187 1488-2104 32.728 µM -1.20168976064282 0.105277971771065 no 3008 0.114741874874404 980 2852859
SGTC_2180 6301957 200 µM -1.20172959757939 0.105270528900045 no 3009 0.114734154962698 975 845462
SGTC_2653 dihydrofissinolide 100 µM -1.20436190904051 0.104779568533414 no 3010 0.11422486390516 983 6857746
SGTC_348 k064-0012 10.7 µM -1.2044681583407 0.104759786528065 no 3011 0.114204340993548 964 5066323
SGTC_3173 9105693 49.47 µM -1.2054757743015 0.10457231818049 no 3012 0.114009842357414 978 17096658
SGTC_2333 9017922 200 µM -1.20586385160786 0.104500180721053 no 3013 0.113934995345905 958 3163164
SGTC_2493 resveratrol 26.09 µM -1.20602361380211 0.10447049392381 no 3014 0.113904192787619 944 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_1105 epirubicin 18.1 µM -1.20891548736248 0.103934185816493 no 3015 0.113347657749435 973 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1931 st074438 57.1 µM -1.21148465589525 0.103459401826838 no 3016 0.112854855939327 987 2787313
SGTC_2442 5158906 48.48 µM -1.2126082246152 0.103252261108288 no 3017 0.112639821443597 954 1893835
SGTC_1353 1498-1206 8.11 µM -1.21284055600026 0.10320946617644 no 3018 0.112595393173497 900 6756808
SGTC_1342 1486-1464 234 µM -1.2135411542071 0.103080495504764 no 3019 0.112461494947714 965 3253938
SGTC_2100 5377183 190 µM -1.21524201015256 0.102767878005854 no 3020 0.112136901013729 955 2844202
SGTC_562 3772-2733 112 µM -1.21661036207504 0.102516875335318 no 3021 0.111876249171905 971 2876874 YIL048W NEO1
SGTC_1197 1601-0112 267 µM -1.22574511624079 0.100852660413154 no 3022 0.110147303269623 986 7350313
SGTC_282 k297-0036 65.7 µM -1.22611469914699 0.100785745030728 no 3023 0.110077757541863 994 5061378
SGTC_783 0848-0141 92.7 µM -1.22634052943766 0.100744872930968 no 3024 0.110035277762722 972 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_1401 3807-4679 7.6 µM -1.22646755184058 0.100721888978638 no 3025 0.110011389398121 971 3291456
SGTC_692 k241-0027 77.8 µM -1.22946986055594 0.100179751920742 no 3026 0.10944784567117 966 3600480
SGTC_2868 9035608 32.47 µM -1.23095446356293 0.099912460590756 no 3027 0.109169947928961 979 6462614
SGTC_1917 st066507 28.5 µM -1.23233257447845 0.0996648088408855 no 3028 0.108912438183128 972 3156428
SGTC_1690 st023502 41.2 µM -1.23240461064902 0.0996518760144522 no 3029 0.108898989735857 971 24207482
SGTC_26 0302-0163 425.158 µM -1.23405080773614 0.0993566644239872 no 3030 0.108591986175329 1010 3100915
SGTC_2686 alizarin 95.37 µM -1.2380959615262 0.0986339660691366 no 3031 0.107840240575085 948 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_370 0180-0345 38.7 µM -1.23923435095288 0.098431279408364 no 3032 0.107629361351429 954 3989527
SGTC_3347 9188721 44.724 µM -1.24046484159846 0.0982125375926984 no 3033 0.107401755307335 995 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_1073 triclabendazole 3.09 µM -1.24219052347164 0.0979063668108243 no 3034 0.10708313763446 981 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_2626 ethyl orsellinate 100 µM -1.2442711388278 0.0975381545391012 no 3035 0.106699894697328 983 75653 A natural product.
SGTC_227 fluconazole 33.516 µM -1.24524122894752 0.0973668225653994 no 3036 0.106521545843763 972 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_1925 st057770 10.1 µM -1.2478824039702 0.0969014718007314 no 3037 0.106037062705616 983 5989122
SGTC_1810 st050138 53 µM -1.24847021801684 0.0967981268830406 no 3038 0.105929454159027 1001 3444541
SGTC_651 3253-0966 34.4 µM -1.25102078085534 0.0963506440883869 no 3039 0.105463447908499 986 781462
SGTC_82 0054-0107 293.755 µM -1.25221103524357 0.0961423412632837 no 3040 0.105246487986662 975 3104697
SGTC_2985 9022375 71.43 µM -1.25346999859772 0.0959223743835609 no 3041 0.105017355415252 993 4939335
SGTC_2095 5432005 200 µM -1.25356631129884 0.0959055618203961 no 3042 0.104999841288716 991 783734
SGTC_880 0833-0487 87.2 µM -1.25655765620278 0.0953844643356647 no 3043 0.104456927925226 980 76075
SGTC_1724 st037281 8.293 µM -1.26401290845416 0.0940948223608165 no 3044 0.103112696905496 957 574124 YDL195W SEC31
SGTC_111 0083-0039 52.457 µM -1.26852768211327 0.0933201172051664 no 3045 0.102304785761107 964 759313
SGTC_180 1486-1293 102.781 µM -1.27084711762596 0.0929239545250636 no 3046 0.101891521321004 971 4140536
SGTC_703 3875-0075 71.8 µM -1.27101336257558 0.0928956074909729 no 3047 0.101861947429428 1026 2850814
SGTC_67 0335-0847 266 µM -1.27567760747131 0.0921028939871046 no 3048 0.101034753717345 1001 4552207 YOR254C SEC63
SGTC_759 3486-0358 89.3 µM -1.2761566258177 0.092021766688976 no 3049 0.100950078909731 1012 875103
SGTC_359 0081-0058 15.9 µM -1.27687046781642 0.0919009674867164 no 3050 0.100823990955851 977 3494159
SGTC_2999 9069765 71.4286 µM -1.27761512909392 0.0917750781243914 no 3051 0.100692581725184 979 2097066
SGTC_998 3996-0085 177 µM -1.2793156171854 0.0914880796440331 no 3052 0.100392967632295 992 715391
SGTC_958 1222-0007 33 µM -1.28242248334372 0.090965439654255 no 3053 0.0998472406635179 978 7312461
SGTC_2690 usnic acid 100 µM -1.28344810756948 0.0907933953492442 no 3054 0.0996675643963495 1011 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_972 1319-0219 195 µM -1.28625848368088 0.0903232036057615 no 3055 0.0991764332040533 1001 23903702
SGTC_1331 1472-0049 76.2 µM -1.28650057155586 0.0902827856940305 no 3056 0.0991342097392778 984 24051409
SGTC_1571 st070080 73.4 µM -1.28650398044999 0.0902822166561943 no 3057 0.0991336152749977 970 4315245
SGTC_866 0495-0101 262 µM -1.28747161141447 0.0901208002062361 no 3058 0.0989649791177275 967 635694
SGTC_2428 5615643 7.78 µM -1.28880510085648 0.0898987041253079 no 3059 0.0987329261326708 983 2253075
SGTC_2514 salinomycin 42.74 µM -1.28984091624564 0.0897264673252101 no 3060 0.0985529491808301 998 23682228 A polyether potassium ionophore.
SGTC_5 0352-0601 109.883 µM -1.29020686798122 0.0896656750531433 no 3061 0.0984894210950353 978 762456
SGTC_2353 9059630 146.67 µM -1.29105574290985 0.0895247770082471 no 3062 0.0983421744905347 1003 4779114
SGTC_1755 st041960 45.185 µM -1.29135466815016 0.0894751999886622 no 3063 0.0982903610524765 999 2257073
SGTC_1516 st013856 110 µM -1.29141912521195 0.0894645124038124 no 3064 0.0982791911743533 1000 5281404 A mutagen and neurotoxin.
SGTC_985 1493-0307 8.71 µM -1.29420801295232 0.0890029974990843 no 3065 0.0977967898657345 1000 3278274
SGTC_1184 1269-1718 139 µM -1.29793194286921 0.0883895146674081 no 3066 0.0971553611961663 985 5403821
SGTC_3212 9128307 49.47 µM -1.3010900790009 0.0878717149822102 no 3067 0.0966138116176115 993 27243542
SGTC_158 k038-0087 26.446 µM -1.30123050376153 0.0878487439534782 no 3068 0.0965897835111127 957 X158
SGTC_2912 7964298 10.93 µM -1.30174326673706 0.0877649029574093 no 3069 0.0965020818253986 971 2975850
SGTC_3315 9136395 68.55 µM -1.30489963696501 0.0872501244198098 no 3070 0.0959635124399925 995 16876844
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -1.30799005740996 0.086748289255181 no 3071 0.0954383408193397 1008 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_3044 9093193 49.47 µM -1.31171658868992 0.0861460321910101 no 3072 0.0948078887419611 986 25236277
SGTC_2719 novobiocin 32.65 µM -1.31221056308249 0.086066434714649 no 3073 0.0947245493824405 1007 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_747 3448-8087 38.7 µM -1.31258430384516 0.0860062478812999 no 3074 0.0946615307542371 1016 5168703
SGTC_952 1185-0122 232 µM -1.3164584422352 0.0853842146783852 no 3075 0.0940101090132561 986 678600
SGTC_1390 3413-2614 145 µM -1.31652740513537 0.0853731725756458 no 3076 0.0939985432031733 1012 3421432
SGTC_2039 Aminomethylbenzodioxan 200 µM -1.31689361207 0.0853145546997549 no 3077 0.0939371440061093 1006 15053
SGTC_313 3474-0040 5.03 µM -1.31750523788479 0.0852167204448757 no 3078 0.0938346632539161 1004 1043375 YIL048W NEO1
SGTC_841 0251-0215 91.2 µM -1.31907503736336 0.0849660037227779 no 3079 0.0935720137999108 1003 3888614
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -1.31960445977883 0.0848815731090324 no 3080 0.0934835565468075 961 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_188 3229-0966 278.469 µM -1.32026606484497 0.0847761508598203 no 3081 0.0933731007145396 982 5722370
SGTC_2709 st078560 56 µM -1.32810765657892 0.0835341151404284 no 3082 0.0920712722111802 1007 17250903
SGTC_3000 9075062 71.4286 µM -1.32968840031758 0.0832854044273671 no 3083 0.0918104791307841 958 17057871
SGTC_553 k007-0256 45.7 µM -1.33160612733501 0.0829844213758795 no 3084 0.0914948252077541 1014 6287000
SGTC_1891 st059073 26.2 µM -1.33413571402858 0.0825886605991572 no 3085 0.0910796915918747 997 688754
SGTC_1636 st007707 68.9 µM -1.33722658892635 0.0821070152562096 no 3086 0.0905743426432954 998 403051
SGTC_1959 st077091 55.8 µM -1.33736397167973 0.0820856563754764 no 3087 0.0905519293779889 982 821356 YKL052C ASK1
SGTC_1315 1237-0019 3.69 µM -1.33829713034473 0.0819406890682808 no 3088 0.090399798460536 976 825140
SGTC_2155 5570423 76 µM -1.33913068896349 0.0818113579561153 no 3089 0.0902640656870507 1003 797402
SGTC_2802 7925815 54.55 µM -1.34000899901806 0.0816752499487472 no 3090 0.0901212096373953 988 1262923
SGTC_2887 9044784 58.44 µM -1.3444740083292 0.0809859649745927 no 3091 0.0893975779207801 990 6465546
SGTC_1569 carminic acid 40.6 µM -1.34456722507047 0.0809716215927614 no 3092 0.0893825167350114 1000 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_684 1140-0066 328 µM -1.34475087648051 0.0809433685206458 no 3093 0.0893528493902885 1009 6813534
SGTC_1684 st024538 14.6195 µM -1.34591737792402 0.080764086774322 no 3094 0.0891645818788234 1009 6732859
SGTC_2306 7482397 179.52 µM -1.34630228430272 0.0807049956464429 no 3095 0.0891025247269046 1018 891448
SGTC_1545 lovastatin 49.4 µM -1.35350326378267 0.079605506126651 no 3096 0.0879474540326229 998 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -1.36146574920184 0.0784029811764534 no 3097 0.0866832751710117 1000 5355888
SGTC_3327 9140648 26.9345 µM -1.36153819702291 0.078392103411248 no 3098 0.0866718355340772 985 8029710
SGTC_327 1273-0057 3.96 µM -1.36185929477794 0.0783439055772784 no 3099 0.0866211472225196 983 3108138
SGTC_2492 derrusnin 100 µM -1.3620827355353 0.0783103796421657 no 3100 0.0865858880659394 1004 1715307 Part of coumarin class of compounds.
SGTC_1477 0139-0234 16 µM -1.36287577741851 0.078191476329314 no 3101 0.0864608319375713 1014 620880
SGTC_1945 st075991 56.6 µM -1.36488992446967 0.0778901043781214 no 3102 0.0861438247390985 1001 1084980
SGTC_736 0958-0254 92.6 µM -1.3655466519856 0.077792030633801 no 3103 0.086040650398174 1009 6812352
SGTC_3081 9117243 49.47 µM -1.36571210924698 0.0777673365237695 no 3104 0.0860146710327002 1009 45595589
SGTC_78 0336-0123 156.75 µM -1.36727368634771 0.0775345677827033 no 3105 0.0857697681618034 989 6765896
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -1.3704986539504 0.0770555289980447 no 3106 0.0852656476472985 1016 521171
SGTC_2372 9071633 200 µM -1.37057592427596 0.0770440788684061 no 3107 0.0852535961943201 1013 21321366
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -1.37103228633086 0.0769764802515428 no 3108 0.0851824457904108 979 5024745
SGTC_3109 9122853 49.47 µM -1.37183076143268 0.0768583146043789 no 3109 0.0850580643391175 1027 1234709
SGTC_152 4469-0003 551.229 µM -1.3725412162763 0.076753290983473 no 3110 0.0849475086153765 1003 697280
SGTC_1222 0366-0074 1.18 µM -1.37317672683387 0.0766594385630956 no 3111 0.0848487064711423 1016 286520
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -1.37523798438703 0.0763556319054916 no 3112 0.084528837887861 1002 6857784
SGTC_2472 5377652 49.4 µM -1.37817725191401 0.075924002002843 no 3113 0.084074284421272 1026 1610903
SGTC_3316 9136639 10.545 µM -1.37823273612756 0.075915872079505 no 3114 0.0840657215505044 981 4903665
SGTC_954 1189-0853 2.85 µM -1.37871814719814 0.0758447746234077 no 3115 0.0839908360487193 984 2828194
SGTC_503 tyrphostin 8 294 µM -1.37954018465104 0.0757244876584555 no 3116 0.0838641326614939 1033 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_1588 farnesol 29.9 µM -1.38056420593857 0.0755748481656476 no 3117 0.083706497687432 1006 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_993 3909-8757 62.7 µM -1.38159456015606 0.0754245107555566 no 3118 0.0835481126050007 1003 4288324 YLR208W SEC13
SGTC_1139 k015-0024 46.9 µM -1.38162998365135 0.0754193462231234 no 3119 0.0835426713456055 1004 2766652
SGTC_178 4092-0806 87.505 µM -1.38598883531745 0.074785906661939 no 3120 0.0828751563385341 965 2169044
SGTC_2537 larixol 68.93 µM -1.39177664614764 0.0739510907835358 no 3121 0.0819950220170928 1000 6708759
SGTC_1092 toremifene 6.32 µM -1.39409356926553 0.0736189077912949 no 3122 0.0816446754304362 1024 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_3324 9138759 60.749 µM -1.39593775295162 0.073355318986292 no 3123 0.0813666203387772 1005 45595710
SGTC_1844 rapamycin 4 nM -1.39596611539886 0.0733512707912408 no 3124 0.0813623496011636 949 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_949 1165-0505 146 µM -1.40020512999932 0.0727481520636532 no 3125 0.0807259500488363 1006 6244267
SGTC_27 0485-0001 32.618 µM -1.40465364493688 0.0721193170068288 no 3126 0.0800621481444963 974 2054479
SGTC_1502 4534-4282 27.7 µM -1.40857228393127 0.0715688436389247 no 3127 0.0794808395530952 1032 3278949
SGTC_2058 5236698 133 µM -1.41429014486438 0.0707714149472066 no 3128 0.0786383646833967 1009 766665
SGTC_2002 4023503 131 µM -1.41821346831903 0.0702282187801769 no 3129 0.0780642254604126 1014 4736863 YCR052W RSC6
SGTC_1320 1313-0481 95.3 µM -1.42225708638002 0.0696717287986674 no 3130 0.0774758159404364 999 6813365 YLR208W SEC13
SGTC_2413 inermin 26.06 µM -1.42673951171108 0.0690588234380847 no 3131 0.0768274960880867 988 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_2818 7996756 12.99 µM -1.42684223029213 0.0690448270507584 no 3132 0.076812687779732 1034 2241621
SGTC_2503 beta-caryophyllene alcohol 24.72 µM -1.42730882919661 0.0689812760146929 no 3133 0.0767454483919116 1033 61125 An anti-inflammatory.
SGTC_3213 9129884 49.47 µM -1.42808196474352 0.0688760737709082 no 3134 0.0766341339724979 1001 17190742
SGTC_3181 9108277 49.47 µM -1.42808603062977 0.0688755208440064 no 3135 0.0766335488995522 1020 17097298
SGTC_1347 1493-0251 600 nM -1.43048156519906 0.0685503425049517 no 3136 0.0762894265312916 957 3986378
SGTC_3197 9113331 49.47 µM -1.43429057339224 0.0680357344147271 no 3137 0.0757446796251963 995 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_3009 9080819 71.4286 µM -1.43642136095852 0.0677491625740991 no 3138 0.0754412392205513 1018 17027216
SGTC_1831 st055328 12 µM -1.43906324121564 0.0673951490741941 no 3139 0.0750663027963278 1006 1103068
SGTC_2611 pyromycin 23.93 µM -1.44228538598686 0.0669653171102039 no 3140 0.0746109405773277 1012 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_1153 4055-0057 267 µM -1.44712178492325 0.0663241287313504 no 3141 0.0739314087968849 1004 882706
SGTC_402 epigallocatechin gallate 10 µM -1.44763630417069 0.0662561967891759 no 3142 0.073859396175969 1008 65064 An antioxidant.
SGTC_343 4130-2827 29.8 µM -1.44812017032093 0.0661923611522131 no 3143 0.0737917227144468 1030 1118244
SGTC_598 3937-0236 20.2 µM -1.45187943665955 0.0656980291726375 no 3144 0.0732675655898024 1023 1379313
SGTC_419 nsc-638432 893 µM -1.4524371288883 0.0656249387746252 no 3145 0.0731900493941353 1009 368090
SGTC_1548 st061468 90.8 µM -1.4603867257595 0.0645899167583649 no 3146 0.0720919094515253 1028 390799
SGTC_441 propafenone 146 µM -1.46269395420941 0.0642919065519562 no 3147 0.0717755706126531 1011 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_531 3788-1495 174 µM -1.46567409566512 0.0639085632374976 no 3148 0.0713685472819622 993 2896655
SGTC_585 0kpi-0023 191 µM -1.46570135399676 0.0639050651495402 no 3149 0.0713648325726196 1002 64601
SGTC_2404 5161160 200 µM -1.46688949548777 0.0637527344603467 no 3150 0.0712030592696001 1000 2831543
SGTC_762 1165-0429 115 µM -1.47048138505647 0.0632939385239416 no 3151 0.0707157118223158 1008 5967793
SGTC_272 doxorubicin 8.13 µM -1.48047050418861 0.062031527839581 no 3152 0.0693738633201148 1033 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2993 9054257 71.4286 µM -1.48062884306187 0.0620116765494483 no 3153 0.0693527525085908 1000 6470217 YGL055W OLE1
SGTC_1443 4112-3303 14 µM -1.48449524940115 0.0615284735375502 no 3154 0.0688387912641725 1027 704433
SGTC_3137 9097352 49.47 µM -1.49204536010197 0.0605933830848569 no 3155 0.067843627205168 1003 44120435
SGTC_2232 chlorophetanol 41.5365 µM -1.49945713487076 0.0596862756260878 no 3156 0.066877540486358 1041 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_2578 7,8-dihydroxyflavone 64.44 µM -1.50043412139023 0.0595675027501241 no 3157 0.066750993214759 1006 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_1425 4048-4433 7.33 µM -1.50047393796478 0.0595626661549056 no 3158 0.0667458397792018 1053 23734946
SGTC_1288 0973-0013 65.5 µM -1.50122041246517 0.0594720474360733 no 3159 0.0666492810098591 1034 4315430
SGTC_2360 9040895 200 µM -1.50145625454077 0.0594434397221391 no 3160 0.0666187965974711 1016 4914414
SGTC_573 3702-0553 84.7 µM -1.50903638031441 0.0585297006065678 no 3161 0.0656447429999246 1018 1222756
SGTC_3255 9139072 49.47 µM -1.50996153577589 0.0584189378577153 no 3162 0.0655266196106341 1024 17646060
SGTC_1190 1486-1332 13 µM -1.51194614965196 0.0581818885054011 no 3163 0.0652737812046168 1011 4150046
SGTC_3054 9094397 49.47 µM -1.52000871546537 0.0572266298984996 no 3164 0.0642543926004004 1023 2598354
SGTC_569 4130-2812 160 µM -1.52066569564804 0.0571493375112481 no 3165 0.064171875732177 1021 743552
SGTC_201 4262-0159 12.803 µM -1.52198813406846 0.0569940044978406 no 3166 0.0640060269584869 1051 1341029
SGTC_2698 st077697 67.5 µM -1.53562356647851 0.055411710182798 no 3167 0.0623153654267307 1026 3154499
SGTC_2394 5221648 200 µM -1.5470898944657 0.0541081501641514 no 3168 0.060920785199656 1036 788586
SGTC_3083 9117465 49.47 µM -1.55129349514345 0.0536363848343505 no 3169 0.0604156824944958 1037 16420915
SGTC_1221 2958-7315 257 µM -1.55139702135613 0.0536248074474049 no 3170 0.0604032843074558 1031 4562705
SGTC_1326 1431-2094 10.8 µM -1.55278448327067 0.0534698378732043 no 3171 0.060237315456755 1022 616278
SGTC_273 hydroxyurea 18.1 mM -1.55712258366128 0.0529875914618737 no 3172 0.0597206920616962 1040 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_2308 7584454 197.62 µM -1.56527613233332 0.0520905389319555 no 3173 0.0587590885055974 1024 893577
SGTC_2489 cantharidin 73.42 µM -1.57004685669086 0.0515712848577632 no 3174 0.0582021053503037 1012 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2964 9083345 53.42 µM -1.58237755998489 0.0502482440328263 no 3175 0.0567817021673406 1008 17741579
SGTC_1712 st032288 53.4 µM -1.5889392334088 0.0495553088607505 no 3176 0.0560370562308027 1031 2883011
SGTC_2105 5350118 200 µM -1.58980786075206 0.0494641531986506 no 3177 0.0559390607289656 1030 2133313
SGTC_2072 5231554 129 µM -1.59010703307805 0.0494327884027671 no 3178 0.0559053404677584 1029 789545
SGTC_1539 benzyladenosine 56 µM -1.59573259511213 0.0488459632988132 no 3179 0.0552742540125177 1021 92208 A nucleotide analog.
SGTC_292 k038-0015 474 µM -1.5959133592449 0.0488271997782031 no 3180 0.0552540692290016 1037 46368540
SGTC_1 0258-0098 57.368 µM -1.60104447294924 0.0482969826418627 no 3181 0.054683534660301 994 6790032 YDR047W HEM12
SGTC_2722 naftopidil 47.16 µM -1.60228773220904 0.0481692076937129 no 3182 0.0545459986107684 1029 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_525 k781-2675 26.7 µM -1.60342229475911 0.0480528401347146 no 3183 0.0544207260448178 999 3651118 YDL195W SEC31
SGTC_859 0439-0102 54.6 µM -1.60519155415352 0.0478718233385687 no 3184 0.0542258277933769 1027 610143
SGTC_623 k072-0108 16.9 µM -1.6077128711138 0.0476148056370512 no 3185 0.0539490391548749 1028 5382803
SGTC_271 rotenone 740 µM -1.60945456517988 0.0474379073561685 no 3186 0.0537584911040484 1047 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_667 1498-1044 59 µM -1.61140925194435 0.0472400036036705 no 3187 0.0535452760091808 1051 6739982
SGTC_68 0986-0284 82.829 µM -1.6293423507714 0.0454550826646381 no 3188 0.0516202827186528 1004 423278 YIL048W NEO1
SGTC_2894 9048625 32.47 µM -1.63052156394438 0.045339639693473 no 3189 0.0514956557328398 1036 4092861
SGTC_944 3370-0224 231 µM -1.63172048384302 0.0452225093668295 no 3190 0.0513691914378923 1025 4580514
SGTC_1808 st050063 61.5 µM -1.63267575072851 0.0451293574666762 no 3191 0.0512686050493529 1030 4011993
SGTC_2108 5365811 200 µM -1.63720417048373 0.0446898719993711 no 3192 0.0507939079682467 1021 780283
SGTC_1754 st042065 16.137 µM -1.63733975209191 0.0446767670686002 no 3193 0.050779749605394 992 1126236 YIL048W NEO1
SGTC_1322 1348-1070 12 µM -1.63745626932174 0.0446655073191271 no 3194 0.0507675845868247 1037 6758089
SGTC_611 3453-1652 23.7 µM -1.6380845883072 0.0446048285242398 no 3195 0.0507020247357783 1045 1560575
SGTC_1465 k213-0056 144 µM -1.63850239482607 0.044564516367406 no 3196 0.0506584674429237 993 24048857 YMR208W ERG12
SGTC_2236 dapsone 200 µM -1.64096708624115 0.0443273069176766 no 3197 0.0504021238314933 1040 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_3049 9092223 49.47 µM -1.65674430353567 0.0428328667474352 no 3198 0.0487855908883229 1040 8623917
SGTC_570 0987-0065 62.6 µM -1.66829432396413 0.0417648602907786 no 3199 0.0476286570728429 1010 3104428
SGTC_2042 p-Dimethylaminoacetophenone 200 µM -1.66991778050154 0.0416164864098324 no 3200 0.0474678159639508 1052 75037 A free radical scavenger.
SGTC_2696 st077691 74.316 µM -1.67628214604599 0.0410389360902665 no 3201 0.0468414701812706 1035 757133
SGTC_2580 diallyl disulphide 81.36 µM -1.67823654087942 0.0408628899167613 no 3202 0.0466504654537538 1033 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_1448 4255-0083 152 µM -1.68000855273312 0.0407038023099025 no 3203 0.0464778258404107 1058 5399660
SGTC_257 daunorubicin 18.5 µM -1.68075576018638 0.040636870378969 no 3204 0.0464051824596053 1017 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1030 k029-0042 36.7 µM -1.68559992456851 0.0402051129092386 no 3205 0.0459364418829933 1030 6080581
SGTC_1856 st057054 55.7 µM -1.68603285320126 0.040166708318743 no 3206 0.0458947358444863 1028 1266018
SGTC_2356 9061756 188.97 µM -1.69002394929053 0.0398140648476686 no 3207 0.0455116864555085 1041 20104043
SGTC_2656 pseudo-anisatin 100 µM -1.714297947381 0.037723122433541 no 3208 0.0432370099662932 1071 6708809 A neurotoxin.
SGTC_1929 genistein trimethyl ether 50.5 µM -1.7152631142778 0.0376418728680052 no 3209 0.0431484990011645 1024 136420
SGTC_289 k017-0060 526 µM -1.72714499759615 0.0366532905437438 no 3210 0.0420708130118187 1055 5512909
SGTC_1921 5740136 50 µM -1.72829440319531 0.0365587962039611 no 3211 0.0419677279890041 1033 1774243
SGTC_438 sphingosine 6.67 µM -1.72865038195563 0.0365295711173661 no 3212 0.0419358433569991 1054 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_1474 0330-0125 5.35 µM -1.7335386490441 0.0361301850211137 no 3213 0.0414999871079425 1064 X1474
SGTC_1704 st028805 70.8 µM -1.73430785385074 0.0360676654872401 no 3214 0.041431737352016 1044 2876101
SGTC_3123 9126162 49.47 µM -1.73820411978491 0.035752343851117 no 3215 0.0410874267248399 1034 25239884
SGTC_3264 9137442 49.47 µM -1.74423252488261 0.0352689245188451 no 3216 0.0405592760137654 1022 17015726
SGTC_918 glabranin 770.725 nM -1.74744094392661 0.0350138347189275 no 3217 0.0402804402414735 1059 124049 Also referred to as licorice root.
SGTC_287 k060-0039 29.6 µM -1.74969089738055 0.0348358538335093 no 3218 0.0400858326228437 1052 5861974
SGTC_847 0342-0274 5.54 µM -1.75155377142309 0.0346890552532289 no 3219 0.0399252837749062 1046 18097
SGTC_983 1491-0821 12.2 µM -1.75220693001277 0.0346377053584156 no 3220 0.0398691162306939 1047 46495113
SGTC_1501 4491-0275 38.4 µM -1.75832251399835 0.0341599340548208 no 3221 0.0393463245171159 1057 5104718
SGTC_220 paclitaxel 373.376 µM -1.75897910666808 0.0341089623114381 no 3222 0.0392905286941654 1042 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_449 xestospongin c 11.1929 µM -1.76256541990848 0.0338316568113392 no 3223 0.03898690681398 1057 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_2568 diosmetin 100 µM -1.76435336094527 0.0336941017093373 no 3224 0.0388362526033439 1047 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_2944 9067346 25.62 µM -1.76440272128245 0.0336903107136642 no 3225 0.0388321001731922 1036 6473075
SGTC_2414 st077232 92.9 µM -1.76527519266613 0.0336233606711656 no 3226 0.0387587633300692 1043 729801
SGTC_1756 st041558 35.5 µM -1.76675961945533 0.0335097032205816 no 3227 0.0386342469967951 1050 3955792
SGTC_1439 4092-1168 46 µM -1.77451208925905 0.0329212512578433 no 3228 0.0379892421022709 1066 2886240
SGTC_1740 st038286 13.222 µM -1.77593844899622 0.0328139164374 no 3229 0.0378715313797723 1036 716786
SGTC_856 0433-0016 11.3 µM -1.77600401863343 0.0328089892087195 no 3230 0.0378661273912458 1057 3911780
SGTC_733 4069-0007 56.1 µM -1.77937627419319 0.0325564023072143 no 3231 0.0375890467833551 1051 5717425 YNL287W SEC21
SGTC_3222 9128301 49.47 µM -1.78049075192691 0.032473279748411 no 3232 0.0374978407456809 1013 4911358
SGTC_853 0419-0306 21 µM -1.78732297178343 0.0319675218678055 no 3233 0.0369426516432592 1056 762713
SGTC_1991 st073000 8.92 µM -1.7898172122098 0.031784513158751 no 3234 0.036741650605038 1062 4301969 YIL048W NEO1
SGTC_2267 7931562 200 µM -1.79256956900864 0.0315835712245999 no 3235 0.0365208879591264 1055 934880
SGTC_1775 st081588 35.1725 µM -1.79603561244108 0.031332019779376 no 3236 0.0362444267038798 1022 1426443 YGL099W LSG1
SGTC_2712 st079126 47.7 µM -1.80071730559324 0.0309948738421218 no 3237 0.0358737242717233 1049 3152970
SGTC_298 1391-0729 10 µM -1.80310340709142 0.0308242001941378 no 3238 0.0356859880926496 1055 3237558
SGTC_275 trichlorophene 5.69 µM -1.81357917104914 0.0300840676392997 no 3239 0.0348712697907434 1035 62616
SGTC_3080 9117754 49.47 µM -1.8163429567542 0.0298912763226652 no 3240 0.0346588898133888 1043 9550191
SGTC_1226 3909-7979 35.4 µM -1.82035730424694 0.0296130766539259 no 3241 0.0343523049755322 1046 6615510
SGTC_836 0330-0104 1.35 µM -1.82815505739342 0.0290788219918652 no 3242 0.0337631419252029 1043 46494820
SGTC_1619 st003326 88.7 µM -1.82932933296 0.0289990658615262 no 3243 0.0336751434672879 1007 2849032
SGTC_3087 9117406 49.47 µM -1.83001544992493 0.0289525493837859 no 3244 0.0336238143028163 1044 42546093
SGTC_1723 st034307 2.5525 µM -1.83443722339092 0.0286542531038288 no 3245 0.0332945591983267 1039 867466
SGTC_314 1671-0008 2.74 µM -1.83897723032193 0.0283506445114279 no 3246 0.0329592675972126 1038 3913060
SGTC_2591 skatole 100 µM -1.83993557385792 0.0282868995921208 no 3247 0.0328888482572247 1052 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_2858 9025781 8.96 µM -1.84646488254202 0.0278557657468558 no 3248 0.0324123669306045 1019 4894980 YPL153C RAD53
SGTC_3012 9080433 71.4286 µM -1.85394216887729 0.0273687747192453 no 3249 0.0318737170517748 1045 17688859
SGTC_1362 1611-0397 101 µM -1.85518760057569 0.027288354409551 no 3250 0.0317847208525816 1054 27816
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -1.86759726476631 0.0264977491536975 no 3251 0.030909113987273 1055 115019
SGTC_254 nsc-64875 3.808 µM -1.86776380191333 0.0264872708142127 no 3252 0.0308975005295744 1055 56993
SGTC_48 0382-0018 55 µM -1.86895128096553 0.0264126562182726 no 3253 0.0308147963981689 1057 762596
SGTC_3353 9151644 39.2805 µM -1.88000541304964 0.0257264680825759 no 3254 0.0300536700985705 1061 4909158
SGTC_1489 4065-0444 182 µM -1.88467951097566 0.0254408439678757 no 3255 0.0297365601115748 1050 2877968
SGTC_838 0109-0203 71.4 µM -1.88604615338967 0.0253578349101358 no 3256 0.0296443677409411 1051 759422
SGTC_1367 1812-0510 76.9 µM -1.89176271073871 0.0250130700257182 no 3257 0.0292613018444902 1050 1142582 YDR527W RBA50
SGTC_1672 st016598 6.51 µM -1.89873687268462 0.0245977891534779 no 3258 0.028799540456441 1051 4665860 YNL267W PIK1
SGTC_316 k060-0003 58.6 µM -1.92618442110369 0.0230191777844388 no 3259 0.0270406751799109 1077 6152314
SGTC_1513 0337-0559 19 µM -1.93221208808023 0.022684174195706 no 3260 0.0266666668960254 1054 775073
SGTC_1410 3909-8106 77.9 µM -1.9418578533747 0.0221566384420288 no 3261 0.026077155432887 1057 1039210
SGTC_714 4296-0578 26.1 µM -1.94735919662653 0.021860428190108 no 3262 0.0257458431492815 1071 1589775
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -1.94965331247602 0.0217378973087707 no 3263 0.0256087272476388 1068 364106
SGTC_1023 4482-3888 16 µM -1.95078666555534 0.0216775782868002 no 3264 0.0255412143632991 1062 3303168
SGTC_1602 st001878 87.6 µM -1.96723452798499 0.0208179924267377 no 3265 0.0245780895632008 1054 595405 YLR310C CDC25
SGTC_757 1066-0008 322 µM -1.96851744001748 0.020752176297475 no 3266 0.0245042657377254 1045 6842497
SGTC_571 k831-0106 44.2 µM -1.96916410577932 0.0207190678066717 no 3267 0.0244671246409407 1050 4783639
SGTC_197 4544-0043 41.561 µM -1.9872722233757 0.0198099556224958 no 3268 0.0234461190244044 1066 896523
SGTC_63 0099-0242 26.702 µM -1.99890782245758 0.0192438431737447 no 3269 0.0228091641076952 1069 3898502 YLR359W ADE13
SGTC_2529 gangaleoidin 93.61 µM -2.00756390461634 0.0188316671017975 no 3270 0.0223448267262229 1077 4565183
SGTC_3170 9103054 49.47 µM -2.00804911975373 0.0188087866772737 no 3271 0.0223190361186993 1043 16432970
SGTC_2836 9010338 19.48 µM -2.01515750931401 0.0184762913240997 no 3272 0.0219440740288737 1070 2994051
SGTC_131 0141-0277 33.849 µM -2.01804290410111 0.018342762147409 no 3273 0.021793396596167 1074 1547771
SGTC_1111 tnp00062 510.699 nM -2.02244915035814 0.0181404382248755 no 3274 0.0215649858854284 1066 676306
SGTC_1797 st048695 56.8 µM -2.02323008573772 0.0181047787612797 no 3275 0.0215247155988609 1054 592262 YIL048W NEO1
SGTC_2909 7941780 10.49 µM -2.03728656720522 0.0174730698526201 no 3276 0.0208106665790935 1057 1243215
SGTC_1431 4049-0260 9.09 µM -2.04791447473366 0.0170080255379262 no 3277 0.0202841901517584 1071 3854841
SGTC_1206 3978-0017 132 µM -2.05706913180343 0.0166159683847245 no 3278 0.0198397882298737 1045 3873677
SGTC_2838 9002687 71.43 µM -2.07062462192619 0.0160496573218675 no 3279 0.0191969446839841 1066 6457060
SGTC_1546 5-methoxyflavanone 78.7 µM -2.07465156755561 0.0158846427939574 no 3280 0.0190094195626137 1078 147795
SGTC_3110 9122132 49.47 µM -2.08791908633158 0.0153512243854692 no 3281 0.0184025670846784 1077 918317
SGTC_929 2805-0021 398 µM -2.09874461450681 0.0149274519897274 no 3282 0.0179197097643381 1077 3098024
SGTC_616 4092-0450 108 µM -2.09938076520548 0.0149028654122301 no 3283 0.0178916744506374 1077 787165
SGTC_2157 5649910 96.377 µM -2.10381605882891 0.0147324115115297 no 3284 0.0176972477127486 1075 2858091
SGTC_2755 lomerizine 42.69 µM -2.10630680712088 0.0146374262748307 no 3285 0.0175888552018861 1056 3949 A calcium channel blocker.
SGTC_1376 2910-0861 41.3 µM -2.11797444963379 0.0141994621760299 no 3286 0.0170886158066873 1079 1112859
SGTC_713 1488-1073 324 µM -2.12167680306891 0.0140628688196836 no 3287 0.0169324439448828 1077 3312542
SGTC_162 k030-0015 37.8 µM -2.12216183913347 0.0140450582351019 no 3288 0.0169120749487663 1070 1809920 YMR134W ERG29
SGTC_2876 9059903 25.97 µM -2.13447521580198 0.0135993765573486 no 3289 0.0164019501634958 1068 6916095
SGTC_2080 5212524 12.4 µM -2.14976574813933 0.0130629692351742 no 3290 0.0157868743952656 1068 260183
SGTC_1142 3253-1408 9.78 µM -2.15830098357357 0.0127715737344319 no 3291 0.0154522191564446 1084 256655
SGTC_2674 ligustilide 100 µM -2.1586110076571 0.0127610961128141 no 3292 0.0154401790254204 1081 5319022 A signalling regulator.
SGTC_1032 k061-1018 98.7 µM -2.1889376454808 0.0117714672185448 no 3293 0.0143006862114092 1081 4005393
SGTC_3108 9121785 49.47 µM -2.21396194256867 0.0110057075560002 no 3294 0.0134156985174432 1019 17140271
SGTC_1699 st031318 29.054 µM -2.22418607450744 0.0107055367710816 no 3295 0.0130679637896351 1072 5340658
SGTC_982 1491-0518 27.5 µM -2.25828771313453 0.009755292947851 no 3296 0.011963863906368 1078 3091256
SGTC_2896 9052656 71.43 µM -2.27395182073837 0.00934408900033071 no 3297 0.0114844417305727 1039 6469436
SGTC_874 0599-0792 117 µM -2.29148507188269 0.00890187699723436 no 3298 0.0109676871456312 1074 765305
SGTC_1777 st045864 34.765 µM -2.29274214161053 0.0088708883673796 no 3299 0.0109314274057191 1089 4691462
SGTC_1128 3448-9350 235 µM -2.29924506806959 0.00871208641686571 no 3300 0.0107455135815165 1063 619386
SGTC_3025 9087895 49.47 µM -2.3080894466224 0.00850010914317241 no 3301 0.0104970810185755 1073 17173641
SGTC_533 1222-0222 6.71 µM -2.3085293532664 0.00848968488017579 no 3302 0.010484856081472 1079 3982874
SGTC_3288 9119690 36.221 µM -2.31507013269784 0.00833600933804709 no 3303 0.0103045471254874 1087 17595618 YKL019W RAM2
SGTC_3104 9120930 49.47 µM -2.31702538177882 0.00829054751631467 no 3304 0.0102511745830851 1079 17014836
SGTC_1457 k015-0032 57.3 µM -2.31810399974008 0.00826556169705389 no 3305 0.010221834797466 1081 4302660
SGTC_1297 1068-0111 14.1 µM -2.35605195912128 0.00742758373468479 no 3306 0.00923516697994742 1077 767057
SGTC_2279 7948423 32.93 µM -2.37028901762735 0.00713306470024659 no 3307 0.00888709252603373 1070 1247112
SGTC_2480 5767542 37.17 µM -2.37592834126155 0.00701928442666635 no 3308 0.00875243097298729 1080 2867358
SGTC_1928 4'-methoxychalcone 40.3 µM -2.40423583347675 0.00647201229335234 no 3309 0.00810315724607668 1070 641818
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -2.41522260884495 0.00626999098550271 no 3310 0.00786279773336481 1082 688761
SGTC_1473 k844-0725 134 µM -2.41855044251565 0.00620991161025009 no 3311 0.00779124245437624 1083 54682906
SGTC_626 0214-0009 33 µM -2.43314240908482 0.00595245155142319 no 3312 0.00748420621529779 1085 3437874
SGTC_1300 1094-0077 113 µM -2.43797993459291 0.00586921208699369 no 3313 0.00738479690490355 1085 5532636
SGTC_536 3852-0578 10.6 µM -2.46628686334697 0.0054025151366574 no 3314 0.0068260974934524 1079 2869208
SGTC_3190 9110366 49.47 µM -2.47792655769926 0.00522038650623252 no 3315 0.0066074171622153 1080 17123768
SGTC_2821 7996764 71.43 µM -2.51223127305409 0.00471497930699013 no 3316 0.00599852184475713 1063 2987135
SGTC_1880 MG-132 525 µM -2.52360044826003 0.00455737841063831 no 3317 0.00580799347082296 1059 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_1412 3909-8563 178 µM -2.5293367107894 0.00447966067618778 no 3318 0.00571391678508832 1088 23767530
SGTC_1623 st003709 20.3 µM -2.56624646527482 0.00400728778507082 no 3319 0.00514028753379928 1086 16192618
SGTC_1622 st003707 19.4 µM -2.58853059822232 0.00374417564257419 no 3320 0.00481931916655665 1081 10140899
SGTC_636 0kpi-0074 126 µM -2.5973006808284 0.0036449486560855 no 3321 0.00469798171062659 1086 616434
SGTC_3126 9127922 49.47 µM -2.60749437716673 0.00353258454990974 no 3322 0.00456037842380555 1063 45595682
SGTC_1452 4194-0072 190 µM -2.62766171410741 0.0033194025279808 no 3323 0.00429869831236735 1082 1343545
SGTC_47 0149-0135 24.25 µM -2.62849202257901 0.00331087892902841 no 3324 0.00428821835188852 1085 5239155
SGTC_760 0568-0725 82.9 µM -2.6299093758332 0.00329637443410592 no 3325 0.00427038161306229 1083 3916171
SGTC_989 1501-0895 10.3 µM -2.64121460740321 0.00318271253275572 no 3326 0.00413046865594209 1084 2830112
SGTC_1416 3966-0321 25.3 µM -2.64895616709241 0.00310692687913278 no 3327 0.00403704014598595 1090 582530 YLR208W SEC13
SGTC_1703 st026983 48.3 µM -2.68897135670396 0.00274049914520208 no 3328 0.00358362844144111 1086 1104023
SGTC_980 1473-0395 201 µM -2.80642991216285 0.00187910318005518 no 3329 0.00250469043729659 1090 768876
SGTC_3131 9127911 49.47 µM -2.81854968915864 0.00180596485925196 no 3330 0.00241205718448242 1079 45595681
SGTC_1212 0520-0165 585 µM -2.82001773393021 0.0017972838272483 no 3331 0.00240104977676822 1083 5403258
SGTC_451 chloral hydrate 100 µM -2.83495000389335 0.00171111651052377 no 3332 0.0022916428882659 1091 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_2987 9018338 71.43 µM -2.88653681901917 0.0014415809695135 no 3333 0.00194753585199363 1086 5055682
SGTC_2704 st078022 71.1 µM -2.9184038325939 0.00129506173188184 no 3334 0.00175914189717952 1087 54697681
SGTC_411 enrofloxacin 100 µM -2.96080388910768 0.00112121102771056 no 3335 0.00153418624645814 1085 71188 A bacterial gyrase inhibitor.
SGTC_1358 1509-0022 2.48 µM -3.05401698642257 0.000811651688210368 yes 3336 0.00112899647687036 1091 3258434
SGTC_1943 st076331 65.2 µM -3.09861621181568 0.00069330155892472 yes 3337 0.000972133507336771 1094 24208415
SGTC_3284 9108171 64.8615 µM -3.10174814927109 0.0006856201883592 yes 3338 0.000961907775247529 1089 8687505
SGTC_2162 5663267 200 µM -3.12748342574677 0.000625411725989648 yes 3339 0.000881548802359834 1087 6456493
SGTC_171 k064-0041 9.68 µM -3.13885977880096 0.000600385354031928 yes 3340 0.000848032932532305 1084 53325
SGTC_1313 1220-0047 237 µM -3.14945203227935 0.000577918793597991 yes 3341 0.000817884798396308 1084 3528706
SGTC_3145 9085516 49.47 µM -3.16066776284187 0.000554978652039219 yes 3342 0.000787039648970149 1092 25236195
SGTC_541 4513-1321 94 µM -3.16190517368333 0.000552499956944928 yes 3343 0.000783702981925553 1088 747515
SGTC_1298 1079-1278 263 µM -3.1673163263436 0.000541780512231417 yes 3344 0.000769264322730555 1091 2840950
SGTC_3253 9135987 49.47 µM -3.25648115077414 0.000390668113879572 yes 3345 0.000564012099338217 1091 4182430
SGTC_1372 2752-0194 270 µM -3.28310732340125 0.000353784223246278 yes 3346 0.000513347851379537 1088 823334
SGTC_1108 betulinic acid 729.144 nM -3.47324030504625 0.000170735173992669 yes 3347 0.000257107363521497 1092 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_1203 3992-3522 103 µM -3.47733689196824 0.000168009599373 yes 3348 0.000253210534155841 1089 5322312
SGTC_3207 9114163 49.47 µM -3.4865967744868 0.000161998037158347 yes 3349 0.000244604175261359 1089 849233
SGTC_2783 7738165 71.43 µM -3.54985636650476 0.000126012538194742 yes 3350 0.000192720693956993 1092 17201110
SGTC_170 4197-0004 226 µM -3.6286531446028 9.16436407573409e-05 yes 3351 0.000142451861247262 1091 218692
SGTC_130 0136-0219 337.655 µM -3.93745418046962 2.47799254888216e-05 yes 3352 4.11753250099887e-05 1095 234244
SGTC_2976 9009005 19.48 µM -4.37630039480043 3.27592904099819e-06 yes 3353 6.03553145457603e-06 1094 2993148
SGTC_2905 7799065 20.05 µM -4.73866992729685 5.3210630630744e-07 yes 3354 1.07562793494623e-06 1087 1296806
SGTC_538 2922-0838 53.3 µM -4.89510517866999 2.3299824622344e-07 yes 3355 4.91265824184145e-07 1095 777039
SGTC_1469 k284-2957 126 µM -5.528213664514 6.38584954740927e-09 yes 3356 1.61753951206416e-08 1087 23884841