SGTCid condition conc unit LSM2|YBL026W.score LSM2|YBL026W.strain.pval LSM2|YBL026W.strain.significant LSM2|YBL026W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_1745 st081495 74 µM 17.2231738135105 3.53142419459484e-43 yes 1 8.89781405318746e-67 1 13842402 YBL026W LSM2
SGTC_3347 9188721 44.724 µM 16.8810439949986 1.46606402701641e-41 yes 2 3.10189750363464e-64 2 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_138 0850-0259 40.9225 µM 13.8456638773029 1.30870066150519e-28 yes 3 6.75632613700197e-44 8 6813004
SGTC_2041 5107442 45.335 µM 13.180934924092 4.13062535072754e-26 yes 4 5.6490971025728e-40 3 793005
SGTC_1374 2889-5571 141 µM 12.3379358705447 4.08875654482352e-23 yes 5 2.82940240126407e-35 8 2853281
SGTC_2192 5915882 198.485 µM 12.1295213033409 2.10009506367592e-22 yes 6 3.68394326628677e-34 1 2876149
SGTC_1652 st011932 78 µM 12.0152311303335 5.09220105284693e-22 yes 7 1.47771070295242e-33 9 1551076
SGTC_2912 7964298 10.93 µM 11.9026383460794 1.20884551147599e-21 yes 8 5.73318692645142e-33 9 2975850
SGTC_1707 st032323 6.317 µM 11.3847975851575 5.81649587969677e-20 yes 9 2.48918540502722e-30 3 3132057 YMR211W DML1
SGTC_354 2783-3500 4.88 µM 10.6841065387305 8.40465466936453e-18 yes 10 6.04033275974179e-27 2 6740761
SGTC_1915 st067105 30.6 µM 9.78459037912078 3.17119523400164e-15 yes 11 6.5562574621383e-23 7 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_1124 fisetin 1.16336 µM 9.24157129289233 8.91740740886471e-14 yes 12 1.21451784879896e-20 1 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_3247 9135149 49.47 µM 8.55172237684828 4.73908819065696e-12 yes 13 6.06325852165539e-18 4 8934436 YOR116C RPO31
SGTC_1754 st042065 16.137 µM 8.23239394785381 2.69631515385643e-11 yes 14 9.17542961330167e-17 7 1126236 YIL048W NEO1
SGTC_248 streptozotocin 5.23457 mM 7.72624281224732 3.72524591808106e-10 yes 15 5.53836276418531e-15 5 5300 DNA alkylating agent.
SGTC_445 e6 berbamine 66 µM 7.59037723989139 7.33669740621881e-10 yes 16 1.59487730207372e-14 7 6610268 A calcium/calmodulin antagonist.
SGTC_1884 5633444 25 µM 7.34713295406847 2.39914723862433e-09 yes 17 1.01251709187047e-13 4 5724239
SGTC_268 camptothecin 39.6153 µM 7.27056243186874 3.45730845401478e-09 yes 18 1.78996903816473e-13 15 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_2229 7354935 190 µM 7.22072175888109 4.37701943160724e-09 yes 19 2.58561825626003e-13 6 318112
SGTC_1133 3473-0247 50 µM 7.18309835061261 5.22475178897764e-09 yes 20 3.40745192873164e-13 15 711311
SGTC_1740 st038286 13.222 µM 7.1510304420692 6.07154625956479e-09 yes 21 4.30644426813598e-13 1 716786
SGTC_1959 st077091 55.8 µM 7.12229866789882 6.94243420317201e-09 yes 22 5.3070868322554e-13 7 821356 YKL052C ASK1
SGTC_2109 5483026 200 µM 7.04721910256425 9.83062312263199e-09 yes 23 9.12643974036273e-13 15 759335
SGTC_58 0957-0393 9 µM 6.94388996482679 1.57767299883482e-08 yes 24 1.90723828303286e-12 24 6997992
SGTC_948 3448-0295 75.3 µM 6.79560680800891 3.07485042341704e-08 yes 25 5.39287868750158e-12 2 678569
SGTC_610 4215-0184 155 µM 6.75113078933521 3.74627232626892e-08 yes 26 7.33486409191217e-12 10 5605015
SGTC_2140 5586273 200 µM 6.71154570308363 4.46165853435044e-08 yes 27 9.6286728351293e-12 3 854421
SGTC_22 0964-0034 14.468 µM 6.60681403836424 7.05140340176837e-08 yes 28 1.96339392165428e-11 12 138402
SGTC_1818 st052136 56.3 µM 6.60680338054323 7.05172942036667e-08 yes 29 1.96353521395763e-11 6 674169
SGTC_2361 9034121 116 µM 6.58701343082058 7.68292791418334e-08 yes 30 2.24380851115339e-11 10 6496917
SGTC_1074 carmofur 3.8 µM 6.4170971945974 1.58811182675089e-07 yes 31 6.94486260230184e-11 12 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2597 laccaic acid a 100 µM 6.38379391685263 1.82719652766289e-07 yes 32 8.63767709043311e-11 3 5491415 A textile dye.
SGTC_607 4491-0986 66.8 µM 6.27349877607631 2.89317615695905e-07 yes 33 1.76511852093071e-10 2 698981 YDR232W HEM1
SGTC_525 k781-2675 26.7 µM 6.06934001019147 6.6413190083254e-07 yes 34 6.42184845768576e-10 18 3651118 YDL195W SEC31
SGTC_2378 9074213 121.43 µM 6.06534762367891 6.74839791132265e-07 yes 35 6.58342756640577e-10 10 657714
SGTC_3065 9113888 49.47 µM 5.95028256035471 1.0655600405488e-06 yes 36 1.33839984119601e-09 2 16648368
SGTC_1723 st034307 2.5525 µM 5.89696282135458 1.31313301020343e-06 yes 37 1.85126621407544e-09 7 867466
SGTC_351 caspofungin 25 nM 5.77996777745625 2.0641564953518e-06 yes 38 3.73574670239006e-09 14 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_580 1123-0028 41 µM 5.76108266121696 2.21875667328239e-06 yes 39 4.17880469910017e-09 8 1677248 YPR107C YTH1
SGTC_2776 terbinafine 19.92 µM 5.59073717689928 4.21468931709375e-06 yes 40 1.13053802368843e-08 4 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2997 9067075 71.4286 µM 5.50891525805164 5.70002529442584e-06 yes 41 1.80525827498774e-08 9 27209819
SGTC_1313 1220-0047 237 µM 5.45886862339149 6.84222705768998e-06 yes 42 2.39589074029512e-08 3 3528706
SGTC_2275 7947463 200 µM 5.34670001972092 1.02463820709712e-05 yes 43 4.47861430344287e-08 4 1225414
SGTC_1727 st034309 9.9045 µM 5.33158486233203 1.08130556601602e-05 yes 44 4.86796523697959e-08 7 870305
SGTC_1510 1123-0200 71.5 µM 5.31127445896617 1.16216160217784e-05 yes 45 5.44306188588871e-08 6 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_3236 9132701 49.47 µM 5.26322350878792 1.37697481063342e-05 yes 46 7.07756599558066e-08 1 24282524
SGTC_1616 st002734 56.1 µM 5.2149267176907 1.6306027433216e-05 yes 47 9.19449594339749e-08 3 4026101
SGTC_1871 st057448 67.3 µM 5.17103131561251 1.89908955903132e-05 yes 48 1.16402772632045e-07 1 691747
SGTC_2534 helenine 20.12 µM 5.16814856740055 1.9181167999893e-05 yes 49 1.18212171964916e-07 16 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_945 3381-0768 11.3 µM 5.15816552736891 1.98541665091413e-05 yes 50 1.24690554543232e-07 5 1126236 YIL048W NEO1
SGTC_2111 5486399 200 µM 5.13439626269648 2.15478881216127e-05 yes 51 1.41525581827578e-07 18 689674
SGTC_1750 st081859 2.357 µM 5.06540324713014 2.72746076270711e-05 yes 52 2.0376836434971e-07 19 5291695
SGTC_227 fluconazole 33.516 µM 5.05576105189236 2.81814448804188e-05 yes 53 2.14338898297098e-07 36 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_1800 st050079 29.0735 µM 5.02056264801444 3.17401782401954e-05 yes 54 2.57601720445027e-07 13 3645560
SGTC_2845 9003024 42.97 µM 4.99248534464618 3.48797281178812e-05 yes 55 2.9803618988239e-07 4 2990173
SGTC_673 1082-0474 110 µM 4.89246087353836 4.86206776608081e-05 yes 56 4.97914587556096e-07 37 3098046
SGTC_690 glyoxal 20.3 µM 4.88291501336581 5.01706785185677e-05 yes 57 5.22644654396801e-07 20 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_576 1073-0113 22.7 µM 4.82993766318026 5.96558429424082e-05 yes 58 6.82879006349716e-07 28 5439563
SGTC_1082 camptothecin 424.86 nM 4.76062819822074 7.46325951161944e-05 yes 59 9.64956488330045e-07 12 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_332 4112-0506 40.9 µM 4.69430400153561 9.22222894135148e-05 yes 60 1.33757979436286e-06 16 2790355
SGTC_1735 st034310 56.75 µM 4.65497838383566 0.000104420757476915 yes 61 1.62007349326885e-06 3 871153
SGTC_829 1635-0120 117 µM 4.59512287308763 0.000125929266650343 yes 62 2.16247169014649e-06 39 285054
SGTC_3341 9147222 25.867 µM 4.55699828886611 0.000141725368440089 yes 63 2.59449233453905e-06 5 1939759
SGTC_1211 1056-0033 32.3 µM 4.54440788921632 0.000147337278854215 yes 64 2.7544945216779e-06 3 6741922
SGTC_2810 7959871 45.46 µM 4.52853987178785 0.000154706724617905 yes 65 2.96963375128267e-06 12 2974535
SGTC_1233 0325-0408 14.2 µM 4.48464581727643 0.000176929747098584 yes 66 3.65175734767563e-06 3 12874
SGTC_916 4466-0038 42 nM 4.48250146496013 0.000178088428938678 yes 67 3.68865680865512e-06 22 5722064 YGL116W CDC20
SGTC_431 k089-0097 107 µM 4.47274562437468 0.000183450055651849 yes 68 3.86108095392693e-06 11 5499420
SGTC_1803 st050068 52.4 µM 4.45791201214567 0.000191892247077893 yes 69 4.138092899173e-06 13 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_2389 9091542 195.52 µM 4.45478341392639 0.000193718569658152 yes 70 4.19889639578685e-06 4 3626624 YOL127W RPL25
SGTC_2778 tioconazole 65.09 nM 4.36591308271157 0.000252908388958093 yes 71 6.3296407447044e-06 24 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_2677 mitomycin C 100 µM 4.34262169530173 0.000271000722603058 yes 72 7.03962254799885e-06 1 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1050 3232-1156 69.3 µM 4.30935235217309 0.000298942787410123 yes 73 8.18666632251282e-06 21 700529
SGTC_3112 9123419 49.47 µM 4.30517615627627 0.000302633792120589 yes 74 8.3426455532016e-06 5 17015854
SGTC_871 0574-0004 149 µM 4.29327456113975 0.000313386632996656 yes 75 8.802853434037e-06 24 9551173
SGTC_928 2764-0428 58.7 µM 4.2829256958212 0.000323024441445007 yes 76 9.22258909823769e-06 16 662578
SGTC_1229 0139-0193 12.2 µM 4.27259090779859 0.000332923655558403 yes 77 9.66073705241207e-06 18 3090752
SGTC_2619 obliquin 87.91 µM 4.26169400609695 0.000343666274429491 yes 78 1.01441558196675e-05 29 6708593 A bioactive alkalod. YER133W GLC7
SGTC_1239 0337-0584 35.4 µM 4.19799260616151 0.000413187967589604 yes 79 1.3464571081092e-05 29 914301 YML130C ERO1
SGTC_2187 6125751 200 µM 4.17301740740489 0.000443843780970969 yes 80 1.5029598293412e-05 10 874498
SGTC_2342 7990637 118.86 µM 4.1427598969775 0.00048380481499196 yes 81 1.7157557458172e-05 6 2033102 YER133W GLC7
SGTC_584 0986-0246 15.4 µM 4.10563526659285 0.000537382744544124 yes 82 2.0160262756489e-05 24 53315 YDR232W HEM1
SGTC_605 1315-0399 119 µM 4.10459745235625 0.000538956500179635 yes 83 2.02509756388477e-05 8 24020461
SGTC_1761 st044296 37 µM 4.10004769997146 0.000545906245948767 yes 84 2.06532495503682e-05 4 1826700
SGTC_2016 5121758 140 µM 4.07571667974884 0.000584499391234838 yes 85 2.29364220547374e-05 13 2795203
SGTC_1101 ebselen 5.29 µM 4.06702068143774 0.00059889361515663 yes 86 2.38090092538838e-05 4 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_3043 9092303 49.47 µM 4.06397422794337 0.000604013291450076 yes 87 2.41220775539661e-05 5 25236084
SGTC_3140 9094243 49.47 µM 4.00151452375339 0.000718309774807942 yes 88 3.14691655712694e-05 4 19291112
SGTC_1643 st009866 20.2 µM 3.97384617183642 0.000775052180188807 yes 89 3.53606238094968e-05 23 3156273 YOR207C RET1
SGTC_977 1348-1378 135 µM 3.95339499789311 0.000819615785908707 yes 90 3.85250422790811e-05 9 X977
SGTC_1213 1315-0166 115 µM 3.94979116364143 0.000827708791841261 yes 91 3.91097045374065e-05 16 768401
SGTC_606 k015-0008 38.6 µM 3.94924564619146 0.000828940229149583 yes 92 3.91989333416615e-05 4 1970475
SGTC_1479 0549-0158 134 µM 3.94479216302981 0.000839056642250843 yes 93 3.99346105736132e-05 3 5440202
SGTC_1261 0712-0010 12.7 µM 3.92546260030615 0.000884294993297754 yes 94 4.32816096745621e-05 11 2840123
SGTC_2277 7947813 106.88 µM 3.91461136565044 0.000910663156700525 yes 95 4.52749686102658e-05 18 1246798
SGTC_2025 5147754 141 µM 3.8936766671868 0.000963585921148932 yes 96 4.93681174026886e-05 5 315777 YLR208W SEC13
SGTC_2586 curcumin 80 µM 3.87176615957362 0.00102198815117844 no 97 5.40247930314776e-05 11 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_942 3253-1115 227 µM 3.86132439143613 0.00105094797403601 no 98 5.63870272301757e-05 6 46497897
SGTC_16 erodoxin 22.806 µM 3.84464411802319 0.00109877499753587 no 99 6.03637585428349e-05 33 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 3.79039132672981 0.00126846213767789 no 100 7.52050647210128e-05 11 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_514 4466-0038 2.65 nM 3.77162124038763 0.00133253790633036 no 101 8.10951596252116e-05 46 5722064
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 3.74296006896512 0.00143610214180785 no 102 9.09325691892026e-05 21 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1077 5-fluorocytosine 377 nM 3.72931323749344 0.0014879513563739 no 103 9.60011766764974e-05 19 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1493 4348-0038 111 µM 3.72749834374367 0.00149497399739283 no 104 9.66949157059323e-05 38 800424
SGTC_2452 5863136 48.41 µM 3.72064990911574 0.00152174685761341 no 105 9.93553728026802e-05 3 2184096
SGTC_1933 st074711 15.9 µM 3.72063080074101 0.00152182216665568 no 106 9.9362891261156e-05 10 17250958
SGTC_2147 5545932 89.7195 µM 3.71305537940049 0.00155194727957468 no 107 0.000102386028405816 14 797404
SGTC_350 k064-0020 19.8 µM 3.71108687571738 0.00155986391176832 no 108 0.000103185628533659 7 2790705
SGTC_1022 4477-0945 21.3 µM 3.69759367964513 0.00161512748108979 no 109 0.00010882645376091 7 4648966
SGTC_1029 k015-0030 64.7 µM 3.67915127855918 0.00169354781025173 no 110 0.000117005716414826 7 2208316
SGTC_624 k048-0052 28 µM 3.65919004579355 0.00178232050196588 no 111 0.000126506829881062 10 6835531
SGTC_118 0083-0097 135.343 µM 3.64354796677075 0.00185482050415644 no 112 0.000134452755640104 26 5207356
SGTC_2186 6124449 200 µM 3.62975679187549 0.00192095464106455 no 113 0.000141844193241822 24 3834182 YLR033W RSC58
SGTC_1079 idarubicin 2.36 µM 3.62419436460788 0.00194822964832529 no 114 0.000144931783901877 9 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_859 0439-0102 54.6 µM 3.62075736593807 0.00196525810004677 no 115 0.000146870945329964 13 610143
SGTC_3232 9132874 49.47 µM 3.59283706605696 0.00210867655042646 no 116 0.00016354856536287 11 3784940
SGTC_299 1273-0059 1.44 µM 3.58130276572849 0.00217064716229095 no 117 0.000170942592053405 12 2848077
SGTC_1730 st033808 45.1 µM 3.55523234620426 0.0023168424208785 no 118 0.000188822607173122 2 1045166
SGTC_1960 st011366 51.8 µM 3.53236962497955 0.00245232616632966 no 119 0.000205926625751325 8 3972846
SGTC_423 5-fluorouracil 457 µM 3.53135600070191 0.00245849550938269 no 120 0.000206717451264475 38 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1672 st016598 6.51 µM 3.52257556755794 0.00251252726020448 no 121 0.000213687591964283 25 4665860 YNL267W PIK1
SGTC_1547 harmine 94.2 µM 3.5142565979453 0.00256470744211976 no 122 0.000220493302843916 21 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_2675 theaflavin digallate 100 µM 3.45774373908079 0.00294588187575581 no 123 0.000272359626368292 11 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_785 1270-0111 65.3 µM 3.42950767055349 0.0031548462372426 no 124 0.000302338670632365 12 6741994
SGTC_3210 9128157 49.47 µM 3.42899463407107 0.00315876343193134 no 125 0.000302910752490304 19 17590849
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 3.42375139330761 0.0031990489234604 no 126 0.000308815477073335 11 390807
SGTC_3161 9100388 49.47 µM 3.40083284134657 0.00338061995026169 no 127 0.00033590447433927 10 25236368
SGTC_2544 sphondin 68.51 µM 3.38673039794286 0.00349689756426711 no 128 0.000353654290034252 46 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_2307 7538926 6.34 µM 3.38670726439004 0.00349709122030382 no 129 0.000353684109714667 31 96582
SGTC_305 1682-2595 20.8 µM 3.37462211889909 0.00359958529117972 no 130 0.000369585561039608 13 226033
SGTC_1274 0865-0114 173 µM 3.35947597881673 0.00373184245305842 no 131 0.000390452199140115 18 870624
SGTC_1679 SEC14.276 6.7 µM 3.34647738714356 0.00384880443220482 no 132 0.000409226773989092 35 1005053 YMR079W SEC14
SGTC_1939 st074455 53.6 µM 3.3347956616552 0.00395670881078137 no 133 0.000426810503513939 12 1644229
SGTC_2396 5342950 42.78 µM 3.32640667229413 0.00403586147204208 no 134 0.000439867372179487 49 1886677
SGTC_313 3474-0040 5.03 µM 3.31472604480093 0.00414843252680083 no 135 0.000458664892647664 16 1043375 YIL048W NEO1
SGTC_3277 9138724 49.47 µM 3.31274943523798 0.00416775741910981 no 136 0.000461918526567187 15 15943418
SGTC_586 0957-0265 8.15 µM 3.31021341217642 0.00419266950720801 no 137 0.000466124315681715 47 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_1541 2',3',6-trimethoxyflavone 64 µM 3.30975618177959 0.0041971751588756 no 138 0.000466886359889029 11 688801
SGTC_3113 9123498 49.47 µM 3.30030567131345 0.00429127762012568 no 139 0.000482897867957028 12 8897275
SGTC_1698 5-fluorocytosine 1.055 µM 3.29534636090889 0.00434141021763979 no 140 0.000491502196104298 23 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_3167 9103034 49.47 µM 3.29450774071449 0.00434993919755865 no 141 0.000492971145628683 7 5127859
SGTC_2570 licareol 100 µM 3.28141510581323 0.00448505027894952 no 142 0.000516438059441064 8 443158
SGTC_839 0122-0028 230 µM 3.27647438257202 0.0045370027758359 no 143 0.000525559238440331 49 759448
SGTC_2679 rapamycin 1 nM 3.26686585150694 0.00463957884330855 no 144 0.000543725983957154 66 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_595 3909-8003 73.7 µM 3.26101266357363 0.00470307423787908 no 145 0.000555075410819541 8 699517
SGTC_2768 sulfasalazine 50.2 µM 3.22132650463501 0.00515441653818552 no 146 0.000637993458225576 22 5384001 An antioxidant and salicylic acid derivative.
SGTC_2324 6149169 200 µM 3.21583670080081 0.00521979517830897 no 147 0.000650324098639772 11 2888231
SGTC_1868 st057644 42.7 µM 3.1934970274243 0.00549351445992935 no 148 0.000702803923706281 14 688665
SGTC_1602 st001878 87.6 µM 3.17621509985775 0.00571393682306211 no 149 0.000746051351440183 19 595405 YLR310C CDC25
SGTC_1422 4031-0024 15.5 µM 3.17592065429859 0.00571775939033052 no 150 0.00074680899067299 19 782427
SGTC_1696 st025591 34.7925 µM 3.16154020640632 0.00590723455647272 no 151 0.000784685756047042 10 2787147
SGTC_534 k292-0788 63.4 µM 3.15557568973164 0.00598744231419026 no 152 0.000800908495393687 20 4146317
SGTC_1170 0310-0127 64.8 µM 3.1355361231336 0.00626404069331861 no 153 0.00085770150434107 24 774975
SGTC_1168 k815-0004 80.5 µM 3.12953405547188 0.00634905804659227 no 154 0.000875418882083394 30 642433
SGTC_2291 7917025 104.35 µM 3.10587839023961 0.00669416055327383 no 155 0.000948573601068789 20 2964612
SGTC_1650 st011916 45.8 µM 3.09956139876803 0.00678907701916804 no 156 0.000969037018560813 10 242528
SGTC_93 0109-0045 59.227 µM 3.08414323311406 0.00702575317652842 no 157 0.00102069643833309 33 88733
SGTC_122 0236-0016 402.397 µM 3.08207407006858 0.00705806376385825 no 158 0.00102781839844399 28 6808838
SGTC_2195 6536160 144.242 µM 3.06072410596128 0.00739918312674682 no 159 0.00110401225141831 11 3834386
SGTC_2028 5153890 36.43 µM 3.05876597926243 0.0074311847994898 no 160 0.00111125344801931 19 2830968 YPR165W RHO1
SGTC_1256 0570-0116 285 µM 3.05404649582094 0.00750881702554502 no 161 0.00112888542797425 16 410638
SGTC_2311 7694451 200 µM 3.04765762591712 0.00761504723962742 no 162 0.00115316266407082 24 2163142
SGTC_964 1287-0107 19.4 µM 2.99689110853717 0.00850724808452041 no 163 0.00136374059728403 40 51516812 YPR165W RHO1
SGTC_374 0880-0231 82.3 µM 2.98812893594692 0.00867019063764531 no 164 0.00140345555812268 22 6833587
SGTC_2046 4110841 106 µM 2.98496875363395 0.00872962585023747 no 165 0.00141803646259707 24 44119630 YMR134W ERG29
SGTC_266 formosanin C 406 nM 2.97971020835469 0.00882931806413663 no 166 0.00144260596359993 33 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_391 gliotoxin 8.33 µM 2.97163366189267 0.00898437764974788 no 167 0.0014810995147388 16 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_1040 k898-0338 155 µM 2.9679663753957 0.00905556893041317 no 168 0.00149888561142131 4 20969351
SGTC_221 trifluoperazine 10.304 µM 2.96026612163727 0.0092066597103613 no 169 0.00153686701643202 43 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_1665 st014639 11.4 µM 2.95290287388183 0.00935319703991563 no 170 0.00157400496778431 16 981133 YIL048W NEO1
SGTC_1651 st011928 86.1 µM 2.94069229088658 0.00960070164888996 no 171 0.00163739835271985 21 720198
SGTC_3256 9138902 49.47 µM 2.92601469698919 0.00990577254838212 no 172 0.00171667358505608 3 17228773
SGTC_1177 0983-0204 23.6 µM 2.9234886577282 0.00995912083131812 no 173 0.00173066417747482 26 766818
SGTC_2351 9026858 72.31 µM 2.89557040757137 0.0105656444956325 no 174 0.001892350588083 24 1409300
SGTC_1151 3909-8316 15.3 µM 2.89440923797217 0.0105915533418972 no 175 0.00189936356231888 18 800431
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 2.88980086318008 0.0106949251489381 no 176 0.00192742966970859 21 5379071
SGTC_287 k060-0039 29.6 µM 2.88567638594204 0.0107881864218932 no 177 0.00195286766788648 20 5861974
SGTC_1826 st055655 41.6 µM 2.85217799175972 0.0115722208964768 no 178 0.00217103899932859 11 676168
SGTC_1260 0700-1617 7.75 µM 2.84986785613069 0.0116280690968341 no 179 0.00218686981993289 18 2853078
SGTC_1791 st048313 56.1 µM 2.82617424786879 0.0122145091865976 no 180 0.00235538154246093 11 1204976
SGTC_157 1348-1695 65.819 µM 2.80488361016643 0.0127631663360847 no 181 0.0025167375951731 51 5380510
SGTC_1031 k035-0009 16 µM 2.79737717814587 0.0129616264836226 no 182 0.0025759675455521 13 5180959
SGTC_3304 9125678 46.087 µM 2.78873513456374 0.0131934098068107 no 183 0.00264571602665969 40 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_1760 st045453 10.4495 µM 2.78777683907921 0.0132193309522997 no 184 0.00265355440658923 10 3323419 YIL048W NEO1
SGTC_2522 biochanin a 4.94 µM 2.77897124193062 0.0134595822544856 no 185 0.00272656763080606 19 5280373 A possible chelator.
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 2.77003446935075 0.0137072576597606 no 186 0.00280251803124604 16 676296 Flavone; oxidizing agent.
SGTC_1982 st072467 71.9 µM 2.76483406461296 0.0138531847150899 no 187 0.0028475879256951 27 3163533
SGTC_2377 9073351 62.6 µM 2.76464848150499 0.0138584169731255 no 188 0.0028492083161244 19 7337946 YHR072W ERG7
SGTC_389 tpck 16.7 µM 2.74706917291296 0.0143618296610747 no 189 0.00300652254827811 16 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_1724 st037281 8.293 µM 2.74575033261618 0.0144002239311213 no 190 0.00301863442771103 36 574124 YDL195W SEC31
SGTC_1930 st074634 34.3 µM 2.74103946361468 0.0145380899160807 no 191 0.00306225755225934 36 684253 YOR116C RPO31
SGTC_1044 1222-0021 1.78 µM 2.72781627870103 0.0149311584338192 no 192 0.00318775529400786 59 4306703
SGTC_1125 tnp00248 1.32998 µM 2.72604946744284 0.0149843638915225 no 193 0.00320486956212809 27 24207736
SGTC_2585 alliin 100 µM 2.71950515164444 0.0151828604718105 no 194 0.00326898382877898 17 87310 A garlic compound which reacts with lipids.
SGTC_2443 5493264 126.67 µM 2.71239082222429 0.0154012048084454 no 195 0.00333998912275786 17 5340055
SGTC_994 3910-0338 138 µM 2.71117272726138 0.0154388581445597 no 196 0.00335228452110409 38 3479481
SGTC_1424 4048-1941 275 µM 2.70841494484252 0.0155243978811937 no 197 0.00338027191873364 19 X1424
SGTC_3130 9127414 49.47 µM 2.70793370148281 0.0155393664957297 no 198 0.00338517728878119 18 1494646
SGTC_933 2914-0560 114 µM 2.69714918530631 0.0158780723286358 no 199 0.00349679654537312 23 463887
SGTC_1934 st074720 32.6 µM 2.69637723745516 0.0159025575898394 no 200 0.00350491153328073 38 17250992
SGTC_1843 st055809 45.5 µM 2.68950789529162 0.0161218743126081 no 201 0.00357787271568603 23 16413835
SGTC_2681 menadione 3.18 µM 2.65552392487552 0.0172453915693575 no 202 0.00395926581399497 21 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_1950 st077106 7.18 µM 2.64042351843421 0.0177656887720209 no 203 0.00414012397922787 18 13831864
SGTC_1758 st042942 75.2445 µM 2.61801701820018 0.018562372438656 no 204 0.00442211970786496 22 669317
SGTC_2520 obtusaquinone 4.71 µM 2.59477094881847 0.0194208560558481 no 205 0.00473269875200663 27 5967872
SGTC_1776 st049249 45.9 µM 2.58981603517137 0.0196081401396142 no 206 0.00480136168899845 37 1822314
SGTC_1573 oleylamine 1.06 µM 2.56724769105206 0.0204806867327432 no 207 0.00512546799166675 21 5356789 An amine of the fatty acid oleic acid.
SGTC_774 k060-0086 136 µM 2.55853481180468 0.0208262410207855 no 208 0.0052557147614217 28 5911235
SGTC_3279 9140807 49.47 µM 2.55723992962138 0.0208780152037862 no 209 0.00527532090461291 14 45595718
SGTC_2556 citropten 84.59 µM 2.55561950950377 0.0209429590471568 no 210 0.00529994773077894 22 2775 A potential DNA crosslinker.
SGTC_2525 harmine 47.85 µM 2.55174289202701 0.0210990218019664 no 211 0.00535927917098965 20 5280953 A monoamine oxidase inhibitor
SGTC_314 1671-0008 2.74 µM 2.55130377766431 0.0211167613087253 no 212 0.00536603689219472 39 3913060
SGTC_77 0828-0286 12.516 µM 2.54144754338298 0.0215182697794833 no 213 0.00551972551382511 35 745345
SGTC_1049 3226-0134 66 µM 2.53467692034881 0.0217978042474403 no 214 0.00562755383081245 25 5702385
SGTC_2126 5251174 33.877 µM 2.52530930282392 0.0221896118076784 no 215 0.00577982496636547 29 790722
SGTC_2936 9038235 15.59 µM 2.52102089325272 0.0223709511861539 no 216 0.00585074519724865 41 4749415
SGTC_672 1441-0018 53.7 µM 2.52015619600348 0.0224076667458159 no 217 0.00586513842459409 27 251141
SGTC_304 1310-0298 97 µM 2.50415036165875 0.0230965145693708 no 218 0.00613729286194872 29 1550234
SGTC_2293 7624732 200 µM 2.49863603487319 0.0233379291989977 no 219 0.00623361411740265 32 894453
SGTC_2567 aureobasidin a 60 nM 2.49845294074293 0.0233459812633323 no 220 0.00623683514226425 90 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_828 2074-0507 139 µM 2.49713418833485 0.0234040460924461 no 221 0.00626007844239662 31 X828
SGTC_249 wiskostatin 11.211 µM 2.48842700896476 0.0237904818836449 no 222 0.00641547861678519 20 2775510 A n-wasp and actin depolymerizer.
SGTC_2960 9079389 5.97 µM 2.46768901502757 0.0247325083512297 no 223 0.00679942026357793 21 16457355
SGTC_1058 3448-5425 97.3 µM 2.45881094939963 0.0251452572812275 no 224 0.00696990006954797 40 7279705
SGTC_3188 9110789 49.47 µM 2.45500091086921 0.0253241514118133 no 225 0.00704421156967073 44 849217
SGTC_2543 pimpinellin 60.67 µM 2.45497339259219 0.0253254473557757 no 226 0.00704475082339475 20 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_1622 st003707 19.4 µM 2.43962476582 0.0260569831674181 no 227 0.0073512623420721 33 10140899
SGTC_509 pifithrin 175 µM 2.43019128511239 0.0265153038501742 no 228 0.00754542798291869 20 4817 A p53 inhibitor.
SGTC_764 1951-2361 146 µM 2.42548648394127 0.0267463897666288 no 229 0.0076439425029046 45 5438930
SGTC_237 nikkomycin 200 µM 2.42474347370006 0.026783037562435 no 230 0.00765960360519579 35 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_490 phenamil 164 µM 2.41821911195318 0.0271066454813307 no 231 0.00779834096917433 25 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_1084 voriconazole 435 nM 2.41425939058398 0.0273046336966646 no 232 0.00788361649618417 39 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2874 9043904 71.43 µM 2.38894062904958 0.0285992912405869 no 233 0.00844851634840297 29 4463428
SGTC_1163 k060-0048 49.9 µM 2.38687895102393 0.0287069251102749 no 234 0.00849604255242932 19 6809982
SGTC_2816 7982706 58.44 µM 2.38110632134411 0.0290100896205676 no 235 0.00863036463684766 42 2981853
SGTC_197 4544-0043 41.561 µM 2.37696766727232 0.029229075323259 no 236 0.0087278090596383 58 896523
SGTC_1309 pyrazolanthrone 13.4 µM 2.37282236675472 0.0294497872967331 no 237 0.00882637563228136 42 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_2903 5923464 63.88 µM 2.36869664526807 0.0296708289166619 no 238 0.00892544404167307 21 2876576
SGTC_1975 st070967 30.8 µM 2.36733157087329 0.0297442672273378 no 239 0.00895843655359707 55 261391
SGTC_3235 9132602 49.47 µM 2.36701364477364 0.0297613926596695 no 240 0.00896613583787252 31 4912240
SGTC_3212 9128307 49.47 µM 2.35816526584666 0.0302413120624416 no 241 0.00918275731723465 35 27243542
SGTC_1817 st052116 64.4 µM 2.34820447682362 0.0307892229908852 no 242 0.00943208107205955 27 4361398
SGTC_919 tnp00227 403.569 nM 2.34815266942128 0.0307920940906737 no 243 0.00943339316457532 45 1269246 A methoxyflavone. YNL221C POP1
SGTC_667 1498-1044 59 µM 2.3441432677558 0.0310149632439867 no 244 0.00953542211872069 31 6739982
SGTC_2477 5967686 25.23 µM 2.34102662546717 0.0311891275330766 no 245 0.00961539780594569 35 776118
SGTC_612 0302-0167 22.4 µM 2.32615636820557 0.0320312812086348 no 246 0.0100051051778407 37 235821
SGTC_2485 5633444 17.78 µM 2.32207190032182 0.0322658579734718 no 247 0.0101145322160687 35 5724239
SGTC_2658 polymyxin b sulfate 77.05 µM 2.29833220736026 0.033657486141536 no 248 0.0107714443521885 45 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_436 n,n-dimethylsphingosine 3.3 µM 2.29335690037992 0.0339553139789344 no 249 0.0109137329133256 28 5282309
SGTC_444 curcumin 90.4 µM 2.28393642648123 0.0345251719507486 no 250 0.0111876337240692 56 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_3263 9137018 49.47 µM 2.28142173579691 0.0346786106896469 no 251 0.0112617515277565 41 43844957
SGTC_2884 9058502 51.95 µM 2.27561206958314 0.0350352409099263 no 252 0.0114346191516229 30 6471554
SGTC_1384 3089-0840 101 µM 2.2735757333909 0.0351609529172898 no 253 0.011495753933611 17 1069836
SGTC_2571 chrysanthemic acid 100 µM 2.27197574409765 0.035259986730776 no 254 0.0115439877012062 32 2743 An insecticide.
SGTC_339 3091-4833 71.4 µM 2.26339465221123 0.0357950381216195 no 255 0.0118056860607444 61 3240077
SGTC_1527 coumarin 137 µM 2.26087124189278 0.0359536385810093 no 256 0.0118836157024883 32 323 A hepatotoxic, DNA x-linker.
SGTC_2189 6047310 154.431 µM 2.24595844038382 0.0369027243105652 no 257 0.0123533350176705 33 711535
SGTC_2915 7971052 15.16 µM 2.24459348437603 0.0369906071467715 no 258 0.0123971207135202 26 5741558
SGTC_1579 chlormadinone acetate 49.4 µM 2.24441791221968 0.0370019237868296 no 259 0.0124027625445463 35 45114258 A steroidal progestin.
SGTC_1282 0886-0010 32.4 µM 2.23759546852968 0.0374438659733948 no 260 0.0126237236677843 56 2836211 YNL267W PIK1
SGTC_353 1988-1175 58.3 µM 2.22935444734228 0.0379834391908489 no 261 0.0128951652921939 53 2788357
SGTC_2090 5301565 104.445 µM 2.2254061503525 0.0382441888682416 no 262 0.0130269925173677 44 2056344
SGTC_1693 xanthone 101.9 µM 2.21266984053248 0.039095271845824 no 263 0.0134602080676135 42 7020 An insecticide.
SGTC_1088 bifonazole 369 nM 2.21207291393116 0.0391355357281093 no 264 0.0134808136520705 26 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_1420 4'-methoxyflavone 42 µM 2.2101269649013 0.0392670282801969 no 265 0.0135481759632021 22 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 2.20744008341285 0.0394491781705888 no 266 0.0136416643111224 27 279621
SGTC_273 hydroxyurea 18.1 mM 2.1989309368188 0.0400305726069536 no 267 0.0139414167204769 66 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_572 0960-0087 17.7 µM 2.19806627888671 0.0400900387674386 no 268 0.0139721915611944 57 6796365
SGTC_2266 7929956 200 µM 2.19758835442598 0.040122938428917 no 269 0.0139892269305727 39 2967153
SGTC_2504 purpurogallin 52.29 µM 2.19306431442178 0.040435454880081 no 270 0.0141513728304639 31 5281571 An antioxidant.
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 2.19301666304701 0.0404387570808186 no 271 0.0141530892829546 36 803109
SGTC_3050 9093513 49.47 µM 2.19031420083141 0.0406263941028124 no 272 0.0142507288205349 54 25236664
SGTC_291 SEC14.278 35.5 µM 2.18913905309059 0.0407082069692158 no 273 0.0142933674010909 39 1068044
SGTC_952 1185-0122 232 µM 2.17899308749258 0.0414201348423159 no 274 0.0146660908665619 36 678600
SGTC_2689 tacrolimus 100 µM 2.17572574668933 0.0416515356955398 no 275 0.0147878869060508 50 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_2561 acetosyringone 100 µM 2.17007412891327 0.0420542681574055 no 276 0.0150006153550337 44 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_1154 4088-0362 150 µM 2.16786378762899 0.0422126312976804 no 277 0.0150845258974216 45 6618304
SGTC_3305 9127027 53.8275 µM 2.15833678935134 0.0429007375964284 no 278 0.0154508281875791 35 41905295
SGTC_2241 6772625 37.8075 µM 2.15483456969761 0.0431559596453012 no 279 0.0155873909994897 49 2285411
SGTC_2348 9022543 33.42 µM 2.15261111200475 0.0433186282032954 no 280 0.0156746272499823 89 3162678 YDL140C RPO21
SGTC_3077 9117319 49.47 µM 2.14986987729548 0.0435198584870843 no 281 0.0157827544694012 37 17154678
SGTC_295 k015-0027 31 µM 2.14415647907617 0.0439416963260911 no 282 0.0160101754506922 30 3887424
SGTC_2872 9044037 25.97 µM 2.1276020869886 0.045182603441945 no 283 0.0166850445273603 22 6465195
SGTC_1137 ixabepilone 100 µM 2.12264427666731 0.0455596759496775 no 284 0.0168918358649066 53 154225 A novel microtubule stabilizer.
SGTC_971 1315-0384 26.7 µM 2.12230796876803 0.0455853456361269 no 285 0.0169059423714062 43 6769120
SGTC_3350 9150499 3.57 µM 2.12113101913624 0.045675271335353 no 286 0.0169553891136459 48 4910996 YPR165W RHO1
SGTC_1456 k015-0012 13 µM 2.12072942625882 0.0457059879439371 no 287 0.0169722893535655 47 2989616
SGTC_1631 benzylvanillin 81.9 µM 2.11388164724867 0.0462323135123052 no 288 0.0172626885600773 46 75506
SGTC_17 0960-0276 49.807 µM 2.11023258764261 0.0465147645289322 no 289 0.0174191634461039 54 6821114
SGTC_1655 st012546 55.1 µM 2.10269291921064 0.0471027501545408 no 290 0.0177463107132657 32 720985 YLR208W SEC13
SGTC_2220 6782180 200 µM 2.10024046038011 0.0472952859464807 no 291 0.0178538469206041 17 833803
SGTC_2127 5253358 187.912 µM 2.09398754707458 0.0477890399009243 no 292 0.0181305447917526 40 20612
SGTC_359 0081-0058 15.9 µM 2.09008375014519 0.0480993856501175 no 293 0.0183051385621531 59 3494159
SGTC_2773 thioridazine 9.09 µM 2.08936685278747 0.0481565527669227 no 294 0.0183373563364242 37 5452 An antipsychotic.
SGTC_608 k048-0125 159 µM 2.08396757855443 0.0485888523534328 no 295 0.0185815582331559 40 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_2087 5276107 200 µM 2.08333820559798 0.048639445159837 no 296 0.0186102032888212 40 144405
SGTC_2400 5203494 178.7 µM 2.0771187009924 0.0491416740338926 no 297 0.0188953024796956 68 6777674
SGTC_3290 9121031 71.43 µM 2.07709558354988 0.0491435484785068 no 298 0.0188963690645797 32 17014854
SGTC_800 3448-7362 155 µM 2.07708245167319 0.0491446132832933 no 299 0.0188969749615536 116 15991913
SGTC_1525 8-methoxypsoralen 92.5 µM 2.07410144519732 0.0493868069448787 no 300 0.0190349451987655 73 4114 Related to psoralen; DNA damaging agent.
SGTC_1694 st024011 44.9 µM 2.06791649456952 0.0498923460572603 no 301 0.0193239380451459 45 2787533
SGTC_3311 9131146 2.8755 µM 2.06405781156965 0.0502098281925551 no 302 0.0195061176879423 75 4900406 YPR165W RHO1
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 2.05460114734583 0.0509947083367856 no 303 0.0199587723824385 50 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1156 4092-0367 4.88 µM 2.05431420972162 0.0510186752536188 no 304 0.0199726451556334 61 1357585
SGTC_3285 9112818 20.8695 µM 2.05143598596845 0.0512595797349081 no 305 0.0201122538017157 62 17017947 YPR165W RHO1
SGTC_1550 gossypolone 36.6 µM 2.04751376543282 0.0515893216346281 no 306 0.0203038333504968 50 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2092 5303694 80.6725 µM 2.041235270521 0.0521206642595466 no 307 0.0206137237457078 53 1963699
SGTC_3039 9090270 49.47 µM 2.04112992581453 0.0521296164152589 no 308 0.020618957276535 35 17173750
SGTC_2951 9072950 58.06 µM 2.04010148488346 0.0522170771376068 no 309 0.0206701094331006 47 16488155
SGTC_71 0417-1750 47.813 µM 2.0348944468088 0.0526616843886986 no 310 0.0209307474436576 55 6811472
SGTC_3291 9121177 71.43 µM 2.03422371534392 0.0527191731064572 no 311 0.0209645222467536 32 17015612
SGTC_1417 3966-0327 90.4 µM 2.02747987274234 0.05329996228292 no 312 0.0213066803919548 38 651118
SGTC_1086 cerivastatin 2.18 µM 2.02347057689822 0.0536476450139737 no 313 0.0215123270628862 38 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_1920 st075728 45.7 µM 2.02014482113037 0.0539374128291543 no 314 0.021684183924386 53 3400306
SGTC_2292 7671323 168.05 µM 2.01792738531597 0.0541313020253781 no 315 0.0217994122353284 89 937504
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 2.01601057640009 0.0542993489934633 no 316 0.0218994349254009 37 2374 Ca(2+)-ATPase inhibitor.
SGTC_3153 9100258 49.47 µM 2.00861730194319 0.0549513879082455 no 317 0.0222888674933669 45 25236848
SGTC_2084 5306078 60.6385 µM 2.00797775203617 0.0550080816037374 no 318 0.0223228279463029 49 679340
SGTC_2080 5212524 12.4 µM 2.00443429987302 0.0553230331884138 no 319 0.022511779085391 53 260183
SGTC_3036 9090181 49.47 µM 1.99314170388554 0.0563362578586301 no 320 0.0231229662336622 35 25236586
SGTC_660 4031-1742 102 µM 1.9930247753501 0.0563468252397416 no 321 0.023129367104237 71 6738706
SGTC_600 1495-0418 41.6 µM 1.98895372460999 0.0567157203753597 no 322 0.0233531554743725 60 5377768
SGTC_3159 9100096 49.47 µM 1.98758249123287 0.0568404010654101 no 323 0.0234289421544601 50 25236875
SGTC_917 harmaline 728.087 nM 1.98729446305761 0.0568666177120334 no 324 0.0234448874515566 50 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_2701 st077767 14.721 µM 1.98601950197316 0.0569827804828054 no 325 0.0235155792540504 53 5721188
SGTC_2515 chrysin 20.77 µM 1.98378014042971 0.0571872627602065 no 326 0.0236401774976493 36 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_2496 diffractaic acid 79.83 µM 1.979256979568 0.0576020460860475 no 327 0.0238935402824734 60 94870 An apoptosis inducer which activates caspases.
SGTC_3356 9151811 4.48 µM 1.97751429743197 0.0577624836883555 no 328 0.0239917630101281 52 1859254 YPR165W RHO1
SGTC_1816 st051957 91.6 µM 1.97229432309603 0.0582451563115155 no 329 0.0242880086594708 41 674121
SGTC_1400 3771-8998 51.5 µM 1.96608018768393 0.0588238801987717 no 330 0.0246446742974844 19 670767
SGTC_2043 5101342 149 µM 1.96460688668826 0.0589617486447909 no 331 0.0247298771448991 50 678451
SGTC_1039 k821-0043 94 µM 1.96427015404501 0.0589932949509316 no 332 0.0247493854719406 47 15992768
SGTC_1899 st063254 59.6 µM 1.96372626763605 0.0590442761191767 no 333 0.0247809223449795 53 3093813
SGTC_1767 st044992 70.3 µM 1.95396888798569 0.0599647674515656 no 334 0.0253524483410294 44 9600693
SGTC_1342 1486-1464 234 µM 1.95231893934547 0.0601215252223787 no 335 0.0254501751235421 56 3253938
SGTC_193 1273-0060 1.558 µM 1.9520233748384 0.0601496399712228 no 336 0.0254677147462235 48 2847393 YHR072W ERG7
SGTC_1778 st046819 58.9 µM 1.94730691886075 0.0605996736707439 no 337 0.0257489748605942 71 671715
SGTC_2428 5615643 7.78 µM 1.94419498516457 0.0608980468411757 no 338 0.0259359711523595 78 2253075
SGTC_2969 9091408 28.7 µM 1.93176326991091 0.0621014763955551 no 339 0.0266943657525452 60 4286311
SGTC_1158 4092-0494 91.8 µM 1.92300232067358 0.0629606514552143 no 340 0.0272398792060262 41 1148199
SGTC_2612 dictamnine 15.46 µM 1.92298893947153 0.0629619707788946 no 341 0.0272407194661699 94 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_1786 berberine 21.6 µM 1.92280663792156 0.0629799470009809 no 342 0.0272521690765514 69 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2835 9006588 71.43 µM 1.92173203821531 0.0630859913848238 no 343 0.0273197418672367 41 2345538
SGTC_1090 efavirenz 20.7 µM 1.91848390721609 0.0634073712208437 no 344 0.0275248403704499 56 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_2873 9040596 71.43 µM 1.91642569091732 0.063611676006578 no 345 0.0276554666604578 75 6463863
SGTC_1905 st060207 84.5 µM 1.91578628034533 0.0636752500089204 no 346 0.0276961523820047 58 1948547
SGTC_2022 5136654 200 µM 1.91489365293785 0.0637640829937933 no 347 0.0277530337148855 67 1713771
SGTC_974 1326-0144 138 µM 1.91471758032518 0.0637816168628478 no 348 0.0277642651626229 61 5411856
SGTC_1480 1070-0044 41.2 µM 1.90933245309329 0.0643196984562706 no 349 0.0281096091758564 53 3124987
SGTC_257 daunorubicin 18.5 µM 1.9087860778034 0.0643744887731913 no 350 0.0281448467846525 63 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2662 daunorubicin 22.37 µM 1.90705726650018 0.0645480922932394 no 351 0.0282565860964903 69 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2911 7942208 15.64 µM 1.90615816638015 0.0646385216353564 no 352 0.0283148439821754 38 1243384
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 1.89486724665618 0.0657825291800781 no 353 0.0290549956965294 54 91467 include heat shock
SGTC_2558 carylophyllene oxide 100 µM 1.89295293130115 0.0659780361439805 no 354 0.0291820645979177 48 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_1821 st053465 65.6 µM 1.89275133115498 0.0659986515259755 no 355 0.0291954732896994 42 675086
SGTC_499 genistein 192 µM 1.88111475310485 0.0671970729954644 no 356 0.0299781552688987 36 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_2104 5389443 200 µM 1.87866106542394 0.0674519068848732 no 357 0.0301453936413361 66 2244536
SGTC_2532 xanthone 78.9 µM 1.87496413726222 0.0678372702232087 no 358 0.0303988287123749 42 7020 An insecticide.
SGTC_2864 9034755 47.6 µM 1.87056931292763 0.0682975910475036 no 359 0.0307024006840012 53 4930451
SGTC_2996 9066192 71.4286 µM 1.86997314709179 0.0683602196263426 no 360 0.0307437734626208 59 6472854
SGTC_1363 1636-0063 10.4 µM 1.86959868488569 0.0683995803868762 no 361 0.03076978402433 70 6072185
SGTC_121 0557-0495 61.343 µM 1.86681920741941 0.0686922857740993 no 362 0.0309634196475961 73 3104427
SGTC_807 1315-0151 48 µM 1.85714366890161 0.069718749596019 no 363 0.0316453583868375 84 4011080
SGTC_2796 7949634 45.45 µM 1.85660460560893 0.0697762834118646 no 364 0.0316837141082393 71 2971588
SGTC_978 1416-0512 87.4 µM 1.85503423662739 0.0699440960001609 no 365 0.0317956688554455 57 6814003
SGTC_2108 5365811 200 µM 1.84634141330189 0.0708786503564657 no 366 0.0324213240728769 65 780283
SGTC_3152 9099253 49.47 µM 1.84564236595641 0.070954218787828 no 367 0.0324720753590357 111 25236131
SGTC_594 1487-1584 10.8 µM 1.84201076255354 0.0713477986834506 no 368 0.0327367878042611 75 5013332
SGTC_349 k015-0014 24 µM 1.8413851446308 0.0714157697508835 no 369 0.0327825691022724 63 2196908
SGTC_820 1582-0060 59.9 µM 1.83005391838548 0.0726554844149995 no 370 0.0336209383423512 65 3848840
SGTC_3298 9116858 71.43 µM 1.82793767834956 0.0728888313635983 no 371 0.0337794527222739 76 2506942
SGTC_1877 wortmannin 25 µM 1.81405709813274 0.0744336175215256 no 372 0.0348344678142798 64 312145 A covalent inhibitor of PI 3-kinase.
SGTC_62 0180-0423 3.232 µM 1.81291525620529 0.0745617987632593 no 373 0.0349224464049537 76 30102 YGL099W LSG1
SGTC_2177 5811945 192 µM 1.81190690428244 0.0746751346749236 no 374 0.0350002912063761 60 5343475
SGTC_1341 1486-1360 280 µM 1.81059561546546 0.0748227164261627 no 375 0.035101735704185 65 3976547
SGTC_809 3998-0021 90 µM 1.8066997443402 0.075262498151957 no 376 0.0354045537976416 78 715485
SGTC_1421 4029-0249 71.4 µM 1.80448731230848 0.0755131222374892 no 377 0.0355774731975212 62 2894095
SGTC_3088 9117578 49.47 µM 1.80365570644508 0.0756074907434817 no 378 0.0356426486650345 66 678341
SGTC_2069 5228469 200 µM 1.80202743807075 0.0757925226330582 no 379 0.0357705443832101 66 2835210
SGTC_2765 myclobutanil 7.74 µM 1.79903165399995 0.0761338559413129 no 380 0.0360068368376636 82 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_1106 tegaserod maleate 11.7 µM 1.79808751092372 0.0762416717472158 no 381 0.0360815705267632 72 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_2700 st077718 96.8 µM 1.79683122964518 0.0763853120960757 no 382 0.0361812084442117 62 904970
SGTC_2680 butyl paraben 22.24 µM 1.79650392967341 0.0764227686207821 no 383 0.0362072041503566 58 7184 An antifungal and steroid mimetic.
SGTC_2312 7706453 155.7 µM 1.79398339890677 0.0767116889142098 no 384 0.0364079093028617 79 976098
SGTC_2926 9010726 65.15 µM 1.79393875255674 0.0767168140572102 no 385 0.0364114725984875 62 2994293
SGTC_1680 diphenhydramine 100 µM 1.78864911035371 0.0773258791785019 no 386 0.0368356717124856 83 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_2153 5569715 200 µM 1.78699445251961 0.0775171536403862 no 387 0.0369691925932627 73 2054701
SGTC_1770 st043884 66.3 µM 1.78542267834502 0.0776991794892102 no 388 0.0370963914267924 92 670149
SGTC_2088 5278280 127.392 µM 1.78481321726782 0.0777698479013219 no 389 0.037145809368144 62 791502
SGTC_861 0443-0273 110 µM 1.78387135348682 0.0778791551098301 no 390 0.0372222858685794 68 6149169
SGTC_3163 9099914 49.47 µM 1.78061045678651 0.078258496419354 no 391 0.0374880551600327 51 16268368
SGTC_3189 9110682 49.47 µM 1.77988952428941 0.0783425515971773 no 392 0.0375470212190971 68 17122418
SGTC_936 3005-4620 401 µM 1.7793747782843 0.0784026088946632 no 393 0.037589169326367 69 777207
SGTC_1399 3562-5772 25 µM 1.77180563205573 0.0792897640303173 no 394 0.0382134136736164 67 23847490
SGTC_1744 st037937 38.9 µM 1.77085324844976 0.0794019259491214 no 395 0.0382925542291615 69 1016152
SGTC_1981 st071826 47 µM 1.77084032143783 0.0794034491848994 no 396 0.0382936293481787 66 11838600
SGTC_1019 4262-0212 3.4 µM 1.76790644675747 0.0797497305092291 no 397 0.0385382724422827 85 4677213
SGTC_3087 9117406 49.47 µM 1.76568587111141 0.0800125806762588 no 398 0.0387242822329553 66 42546093
SGTC_2089 5281248 129.67 µM 1.76347923949153 0.0802744286244111 no 399 0.038909847854846 73 2737878
SGTC_360 0957-0399 1.01 µM 1.76321668880248 0.0803056270257607 no 400 0.0389319750547368 83 6752301 YPR165W RHO1
SGTC_2096 5468907 200 µM 1.76051708659042 0.0806269473090662 no 401 0.0391600865110626 64 759785
SGTC_946 3434-1334 87.4 µM 1.75833854695322 0.0808869553187939 no 402 0.0393449613038303 80 4047976
SGTC_492 tmb-8 126 µM 1.74837540041954 0.0820841257257394 no 403 0.040199522336515 50 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_356 1634-0012 32.5 µM 1.74240872284427 0.0828074440155986 no 404 0.0407184753308536 84 735457
SGTC_1326 1431-2094 10.8 µM 1.73846062053223 0.0832886877424663 no 405 0.0410648415584607 86 616278
SGTC_1319 1306-0155 43.7 µM 1.73474579056213 0.083743414413857 no 406 0.0413929208975942 82 3122360
SGTC_2232 chlorophetanol 41.5365 µM 1.7295185336755 0.0843864299331105 no 407 0.0418581661793707 69 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_2375 9072683 200 µM 1.728039119514 0.084569086595345 no 408 0.0419906055531161 71 16798029
SGTC_1684 st024538 14.6195 µM 1.71894742993031 0.0856981134201078 no 409 0.0428119723366213 59 6732859
SGTC_1266 0828-0227 32.9 µM 1.71819327142494 0.085792270983947 no 410 0.0428806842127166 79 3913820
SGTC_629 3448-6466 76.7 µM 1.71309298860835 0.0864310808168862 no 411 0.0433477168628416 72 573744
SGTC_771 0250-0039 27.3 µM 1.70558874315498 0.0873774431398121 no 412 0.0440423383525899 80 3005115
SGTC_1080 nisoldipine 24.4 µM 1.70314210233181 0.0876876556562102 no 413 0.0442707392632565 80 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_3246 9135460 32.98 µM 1.70145927944428 0.0879014992263695 no 414 0.0444283890167114 68 41446951
SGTC_3281 9140613 49.47 µM 1.69557480253096 0.0886523231252333 no 415 0.0449832165131151 64 16013766
SGTC_1089 terbinafine 2.25 µM 1.69075428662477 0.0892709429285172 no 416 0.0454418706550235 64 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_3013 9080133 71.4286 µM 1.68860597383177 0.0895476695760614 no 417 0.0456474825563799 71 17050193
SGTC_2890 9046729 58.44 µM 1.68673548017134 0.0897891290939395 no 418 0.0458271132712387 95 903329
SGTC_2380 9035439 200 µM 1.68473684480561 0.0900476647398556 no 419 0.0460196772543085 65 6462575
SGTC_417 st075190 100 µM 1.68336682160505 0.090225204830689 no 420 0.0461520509929662 79 222757
SGTC_214 4373-3496 70 µM 1.68274899152926 0.0903053538933962 no 421 0.046211846647933 118 3779166
SGTC_563 tetrahydrosecaminediol 614 µM 1.68073826129464 0.0905665653843112 no 422 0.0464068826559812 51 334274 A psychoactive constituent of the cannabis plant.
SGTC_694 1315-0438 43.2 µM 1.67614176631672 0.0911657962767466 no 423 0.0468552137269663 60 6793154
SGTC_2319 6033012 152.6 µM 1.66672814673885 0.0924021887187737 no 424 0.0477842367244707 71 847246
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 1.66383202102873 0.0927850528658659 no 425 0.0480730014818518 86 689007
SGTC_1644 st010134 20.9 µM 1.66132614696421 0.0931172718015883 no 426 0.0483239807161211 70 3818134
SGTC_1501 4491-0275 38.4 µM 1.65946337077163 0.0933648004103894 no 427 0.0485112278982835 62 5104718
SGTC_666 0272-0154 136 µM 1.65779613097452 0.0935867577636332 no 428 0.0486793112615519 95 6870312
SGTC_2505 galangin 7.89 µM 1.65492713370056 0.0939696152149734 no 429 0.0489696397503802 85 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_3099 9120367 49.47 µM 1.65421612151393 0.0940646757222453 no 430 0.04904180419283 75 24824940
SGTC_1362 1611-0397 101 µM 1.65405199206815 0.0940866294848935 no 431 0.049058474633808 82 27816
SGTC_1834 st055981 52.8 µM 1.64983066123571 0.0946525694183836 no 432 0.0494887878690674 83 471719 YDL150W RPC53
SGTC_2682 pyrogallin 40.03 µM 1.64038709452534 0.0959277152531391 no 433 0.0504623534753153 77 822798 An ATP competetive kinase inhibitor.
SGTC_3234 9132280 49.47 µM 1.63797810719764 0.0962550092410523 no 434 0.0507131304049469 76 17612295
SGTC_1497 4476-2978 41.3 µM 1.63370905013989 0.0968370340628677 no 435 0.0511599785804578 87 1528379
SGTC_2026 5148700 152 µM 1.6319285320039 0.0970805443907975 no 436 0.0513472713065699 85 79838
SGTC_3322 9139058 2.11 µM 1.63179424725193 0.0970989278862645 no 437 0.0513614188108215 84 4908926 YPR165W RHO1
SGTC_2836 9010338 19.48 µM 1.63178721018162 0.0970998913270761 no 438 0.0513621602834071 68 2994051
SGTC_1334 1486-0610 236 µM 1.63072282290009 0.0972456967110297 no 439 0.0514744092893428 90 3742339
SGTC_2052 5265182 7.135 µM 1.63059286148586 0.0972635105103745 no 440 0.051488128218392 81 1239884
SGTC_450 aminopyrene 156 nM 1.62893911586047 0.0974903983898304 no 441 0.051662954208458 85 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_2850 9015429 58.44 µM 1.62321499268455 0.0982787242577132 no 442 0.0522717269782285 89 6457570
SGTC_1919 st067113 52.3 µM 1.62074493007826 0.0986203394293349 no 443 0.0525361767038039 95 1268243
SGTC_451 chloral hydrate 100 µM 1.61940889565338 0.0988054778027733 no 444 0.0526796570559121 108 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_2697 mebhydrolin 72.4 µM 1.61757009521462 0.0990607017162113 no 445 0.0528776390869189 82 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_1223 0764-0573 147 µM 1.6174533095979 0.0990769277295479 no 446 0.0528902331980258 70 1609797
SGTC_3018 9082602 49.47 µM 1.61026786958019 0.100079004339559 no 447 0.0536696952112511 96 17332089
SGTC_2218 6965428 192.983 µM 1.60763421906117 0.100448138516879 no 448 0.0539576565950819 64 675684
SGTC_2986 9022445 71.43 µM 1.60455631150388 0.100880797831573 no 449 0.0542957412661689 89 6459286
SGTC_849 0386-0493 241 µM 1.59948024883749 0.101597301970942 no 450 0.0548569669078148 84 726119
SGTC_3165 9101544 49.47 µM 1.59853639319049 0.10173093811078 no 451 0.0549618263657149 82 5002184
SGTC_3331 9141060 1.957 µM 1.5975159752964 0.10187555825716 no 452 0.055075369773801 66 4906567 YPR165W RHO1
SGTC_2057 5236571 38.335 µM 1.59608250652836 0.102078971283676 no 453 0.0552351868982695 82 54684039 YBR257W POP4
SGTC_457 grayanotoxin iii 135 µM 1.59530983589775 0.102188737793942 no 454 0.0553214835876228 105 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_2456 5770359 74.46 µM 1.59426875485411 0.102336770755404 no 455 0.0554379263690113 88 3118787
SGTC_1781 st038725 66.3 µM 1.5904791019783 0.102876944522099 no 456 0.0558634262746117 98 4270275 YIL048W NEO1
SGTC_788 1182-0090 188 µM 1.58943273251045 0.103026457416472 no 457 0.0559813647895843 94 5715185
SGTC_1174 0739-0097 51.1 µM 1.58939908634414 0.103031267643703 no 458 0.0559851603767569 88 728447
SGTC_1150 3909-7983 10.9 µM 1.58915488067249 0.103066185418725 no 459 0.0560127150346615 110 23965914
SGTC_879 0831-1030 162 µM 1.58878526550411 0.10311905123281 no 460 0.0560544404701999 120 1549252
SGTC_709 3807-1509 243 µM 1.58017420317963 0.104356264687552 no 461 0.0570334888824457 112 1886677 YPL242C IQG1
SGTC_1891 st059073 26.2 µM 1.57702180989073 0.104811871004234 no 462 0.0573952533901887 98 688754
SGTC_838 0109-0203 71.4 µM 1.56672407770201 0.106310206484231 no 463 0.0585896001420814 80 759422
SGTC_363 0455-0021 3.06 µM 1.56417370440602 0.106683667989228 no 464 0.0588883903743064 112 4597466
SGTC_976 1348-1067 47.6 µM 1.56394337009859 0.106717443336977 no 465 0.0589154340635979 90 5310671 YGL099W LSG1
SGTC_232 clozapine 119 µM 1.56332779655058 0.106807746572366 no 466 0.0589877567457368 84 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_335 4077-0256 27.6 µM 1.56318641275609 0.106828495036513 no 467 0.0590043775174255 107 3121989
SGTC_1936 st074407 74.3 µM 1.55839220898695 0.107533779877307 no 468 0.0595701511890326 111 809813
SGTC_653 0203-0016 55.2 µM 1.55438339056914 0.108126096160038 no 469 0.0600464963623871 87 295302
SGTC_738 1315-0003 72.4 µM 1.54897376210086 0.108929104830237 no 470 0.0606940137687447 93 6251474
SGTC_1454 4239-0054 42.6 µM 1.54239037492125 0.109912118985455 no 471 0.0614893795473676 96 1340767
SGTC_2283 7944793 200 µM 1.54128305980982 0.110078083854154 no 472 0.0616239549762468 87 2970533
SGTC_1901 st060216 58.6 µM 1.53245312867728 0.111407953313135 no 473 0.0627053277676169 85 688792
SGTC_2955 9076254 12.21 µM 1.53213383584333 0.111456256267008 no 474 0.0627447058143342 84 16459619
SGTC_1900 st060200 72.8 µM 1.52507517464552 0.11252792833786 no 475 0.0636201742125815 101 688945
SGTC_400 oxethazaine 37.5 µM 1.52491889467783 0.112551738338858 no 476 0.0636396642328543 91 4621 A local anesthetic.
SGTC_302 1094-0063 18.9 µM 1.52159177146453 0.113059495522312 no 477 0.0640557003100778 122 5440289
SGTC_503 tyrphostin 8 294 µM 1.52074198510872 0.113189444347609 no 478 0.0641622990981051 103 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_527 4476-4215 268 µM 1.51975874642879 0.113339933562765 no 479 0.0642858104204332 72 4418754
SGTC_2083 5306046 65.942 µM 1.51550387714887 0.113992805893076 no 480 0.064822424603817 82 539837
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 1.51312359411605 0.114359205984448 no 481 0.0651241337339682 98 165521
SGTC_1588 farnesol 29.9 µM 1.50632245202045 0.115410733193381 no 482 0.0659922085993961 92 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_2557 derrustone 83.84 µM 1.49900307978764 0.116550040651837 no 483 0.0669364165453505 104 629853 An antioxidant.
SGTC_1945 st075991 56.6 µM 1.49646978026639 0.116946217035235 no 484 0.0672656386071491 105 1084980
SGTC_824 1304-0008 100 µM 1.49514070801088 0.117154448616194 no 485 0.0674388618734751 104 768245
SGTC_886 0866-0150 153 µM 1.49264692709034 0.117545868740256 no 486 0.0677648163394465 93 271463
SGTC_851 0394-0702 453 µM 1.49195133414494 0.117655212918647 no 487 0.0678559518735832 130 762646
SGTC_402 epigallocatechin gallate 10 µM 1.48424849951996 0.118870879658255 no 488 0.0688715037467687 110 65064 An antioxidant.
SGTC_2488 5268135 45.7 µM 1.47677911126201 0.120058150157283 no 489 0.0698674288480181 117 1270356 YLR208W SEC13
SGTC_45 0kpi-0036 14.9 µM 1.47563682383171 0.12024045267974 no 490 0.0700207070521663 86 2795021
SGTC_1814 st052110 31.539 µM 1.47436991035238 0.120442872813649 no 491 0.0701910106934676 99 674163
SGTC_156 3474-0145 5.642 µM 1.47393432809314 0.120512523047221 no 492 0.070249636964298 91 2265471
SGTC_1617 st002906 78 µM 1.46223205382703 0.122394358871783 no 493 0.0718388153362754 99 5150859
SGTC_2933 9026794 32.47 µM 1.46127011076729 0.122549960640331 no 494 0.0719706645114219 93 17586027
SGTC_3336 9143619 71.43 µM 1.46079052606409 0.122627589020877 no 495 0.0720364682865681 69 45595730
SGTC_184 1494-0393 24.714 µM 1.46021474988226 0.122720833076153 no 496 0.0721155314062408 144 3090647
SGTC_2027 5150920 200 µM 1.45970302825316 0.122803745548951 no 497 0.072185854643209 87 786715
SGTC_1030 k029-0042 36.7 µM 1.4572743818928 0.123197786298624 no 498 0.072520327730625 95 6080581
SGTC_3270 9137563 49.47 µM 1.45499644058866 0.123568180112689 no 499 0.0728351234499457 88 17015724
SGTC_1898 st060199 18.6 µM 1.45434767657784 0.123673811839301 no 500 0.072924969272469 92 688866
SGTC_1419 3993-2473 62.6 µM 1.45361344317993 0.123793435939222 no 501 0.0730267538623702 101 704026
SGTC_2964 9083345 53.42 µM 1.45041881812165 0.124314859243706 no 502 0.0734708812913866 123 17741579
SGTC_3321 9137793 26.8275 µM 1.44701692645518 0.124871799038148 no 503 0.0739460914703814 127 4904192
SGTC_575 k072-0246 11.9 µM 1.44504959563255 0.125194674523976 no 504 0.0742219776912123 106 6796779
SGTC_1618 st003135 44.5 µM 1.44476113809735 0.125242064716438 no 505 0.0742624951756074 108 1270615
SGTC_2136 5328288 199.296 µM 1.44425122704632 0.125325867763052 no 506 0.0743341599061617 83 262395
SGTC_2309 7664088 163.95 µM 1.43672720747158 0.126566979926206 no 507 0.0753977604833464 107 704922
SGTC_2473 5854593 8.94 µM 1.43297526979929 0.127189063103631 no 508 0.0759324524123719 112 2872951
SGTC_1849 st056239 19.2 µM 1.42668113655812 0.128237421836282 no 509 0.0768359126433305 100 5393181
SGTC_3342 9147791 14.508 µM 1.42415749358954 0.128659443640354 no 510 0.0772004432029483 91 1838168
SGTC_3187 9109394 49.47 µM 1.42359142324048 0.128754238189928 no 511 0.077282390031608 124 17098090
SGTC_1524 corynanthine 62.1 µM 1.42152256727848 0.129101102416493 no 512 0.0775824488465034 106 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_3141 9094609 49.47 µM 1.42115836238146 0.129162231984805 no 513 0.0776353631519761 139 25236309 YDL196W YDL196W
SGTC_2405 ticlatone 3.52 µM 1.42032104290625 0.129302847035088 no 514 0.0777571188465667 92 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_394 menadione 8.33 µM 1.41784969855614 0.129718490235765 no 515 0.0781173254023362 118 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_3142 9086498 49.47 µM 1.41744460443658 0.12978670918378 no 516 0.0781764897535298 151 25236367
SGTC_303 1348-1668 34.2 µM 1.41695443260183 0.129869288661901 no 517 0.0782481252170582 108 5380509
SGTC_176 1486-1328 72.834 µM 1.41634741075158 0.129971604327906 no 518 0.0783369065446352 124 22310231
SGTC_906 1165-0455 526 µM 1.41625635539224 0.129986956840203 no 519 0.0783502306339153 102 3252859
SGTC_1007 4101-0031 70 µM 1.41609177523076 0.130014709286328 no 520 0.0783743179339394 116 1146276
SGTC_2285 7945142 200 µM 1.41487102830028 0.130220686631527 no 521 0.078553156926511 110 2970608
SGTC_2331 7980721 200 µM 1.41476617815893 0.130238388580779 no 522 0.0785685318483917 127 2981221
SGTC_1109 tnp00067 928.257 nM 1.41163026290144 0.130768597821586 no 523 0.079029428405023 88 676295
SGTC_367 0335-0881 7.1 µM 1.41068661729091 0.130928437648907 no 524 0.079168519366072 128 23828853
SGTC_1802 st050112 57.9 µM 1.40809278303444 0.131368490793009 no 525 0.0795517988889435 99 4662563
SGTC_2921 7974240 10.71 µM 1.40785104060792 0.131409555211394 no 526 0.0795875915123862 112 2979074 YDR527W RBA50
SGTC_1668 st014914 51.6 µM 1.40699813832045 0.1315545072139 no 527 0.0797139704074472 119 2839556
SGTC_2263 7948595 193.29 µM 1.40632372788507 0.131669202368834 no 528 0.0798140086836856 93 2971371
SGTC_956 1185-0240 191 µM 1.40559274657787 0.131793596288953 no 529 0.079922545571384 98 1416193
SGTC_2178 5812956 200 µM 1.4052052510458 0.131859570776813 no 530 0.079980126569449 101 5403383
SGTC_797 k781-0471 270 µM 1.40505172853159 0.131885715621619 no 531 0.080002948356679 113 23738129
SGTC_1462 k081-0014 26.5 µM 1.40458664405091 0.131964941213874 no 532 0.0800721152321919 88 3270634
SGTC_3011 9081274 71.4286 µM 1.40156583926074 0.132480324209756 no 533 0.0805224669744119 105 6625322
SGTC_111 0083-0039 52.457 µM 1.40077169304419 0.132616044339028 no 534 0.0806411779939611 86 759313
SGTC_558 k064-0027 21.3 µM 1.40057602868536 0.132649498212748 no 535 0.0806704466906486 122 5088526
SGTC_1801 st050089 28.441 µM 1.39948390806905 0.132836331201813 no 536 0.0808339602899494 120 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_188 3229-0966 278.469 µM 1.39834218503268 0.133031843507891 no 537 0.081005167828888 156 5722370
SGTC_1870 st057514 26.5 µM 1.39565895633896 0.13349210767471 no 538 0.0814086097501166 108 5393161
SGTC_133 0724-0033 378.92 µM 1.39351643521261 0.133860407805589 no 539 0.0817318392955981 118 280309
SGTC_1382 3002-2117 298 µM 1.39126178653838 0.134248736228689 no 540 0.0820730285729443 113 1497314
SGTC_3268 9137683 49.47 µM 1.38912805657881 0.134616950212146 no 541 0.0823969067880076 127 1953228
SGTC_1247 0448-0043 5.84 µM 1.38894501146622 0.134648570233089 no 542 0.0824247359054072 126 3089013 YGL099W LSG1
SGTC_958 1222-0007 33 µM 1.38859057681257 0.13470981133006 no 543 0.082478642211852 126 7312461
SGTC_2315 7733312 200 µM 1.38565515082478 0.135217744460436 no 544 0.0829261145588056 110 726316
SGTC_835 0312-0010 67.2 µM 1.38194859866404 0.135860983441948 no 545 0.0834937421549036 120 1626196
SGTC_1232 0279-0259 161 µM 1.37367212668615 0.137304844593848 no 546 0.0847717469667354 118 1560000
SGTC_506 n9-isopropylolomoucine 153 µM 1.37095523428204 0.137781092922424 no 547 0.0851944556827747 84 6610355
SGTC_2695 st077686 51.995 µM 1.36908859751291 0.138108951089836 no 548 0.0854857910710325 98 2876092
SGTC_3047 9092122 49.47 µM 1.36515621000389 0.138801379780959 no 549 0.0861019791391709 110 17173831
SGTC_2387 9077560 195.08 µM 1.36406157371282 0.138994547151987 no 550 0.0862740936866334 107 5303272
SGTC_2112 5488546 200 µM 1.36162358102635 0.139425430307778 no 551 0.0866583547000062 121 600757
SGTC_1983 st071813 46.9 µM 1.36131738935461 0.139479609815348 no 552 0.0867067049703471 116 11838595
SGTC_1016 4226-1401 38 µM 1.35999693630169 0.13971342322823 no 553 0.0869154467011182 123 2901613
SGTC_263 alizarin 107.927 µM 1.35772756949313 0.140115883592155 no 554 0.0872750726534067 154 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_519 k048-0011 62.8 µM 1.35771527917954 0.140118065357287 no 555 0.0872770233161288 113 6836379
SGTC_1026 k007-1105 30.6 µM 1.35750093978973 0.140156118399146 no 556 0.0873110475241333 141 7066794
SGTC_3272 9137413 49.47 µM 1.35526567671341 0.140553377296465 no 557 0.0876664631955203 116 17614870
SGTC_2472 5377652 49.4 µM 1.35058381398542 0.141387929662172 no 558 0.0884143943022735 135 1610903
SGTC_2173 5763948 167 µM 1.3491902413231 0.141636984347209 no 559 0.0886379342262632 119 2867177
SGTC_1530 rhein 70.4 µM 1.34570641809431 0.142260901216379 no 560 0.0891986078595129 113 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_803 4488-1585 147 µM 1.34489099328474 0.142407203574346 no 561 0.0893302196228097 111 747204
SGTC_2070 5230947 200 µM 1.33999889477588 0.143287073507579 no 562 0.0901228521243527 121 2835538
SGTC_311 1315-0136 58 µM 1.33881284172091 0.143500943225953 no 563 0.0903158045745124 107 6759207
SGTC_330 1488-0319 80.1 µM 1.33833717042404 0.143586777039873 no 564 0.0903932750586304 137 6846614
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 1.33656575028703 0.143906730581542 no 565 0.0906822125022681 125 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_744 1594-0068 283 µM 1.33270920177506 0.144604961710519 no 566 0.0913136261868601 126 668392
SGTC_79 0052-0007 94.094 µM 1.33215608772366 0.144705290261095 no 567 0.0914044514360535 113 2801472
SGTC_196 k015-0023 18.111 µM 1.32815820554722 0.145431854228037 no 568 0.0920629240987138 83 5211998
SGTC_1052 3253-3998 198 µM 1.3246856624107 0.146064932502847 no 569 0.092637715256947 100 5450317
SGTC_98 0074-0023 107.663 µM 1.32467580506228 0.146066732224175 no 570 0.0926393506597766 97 3563821
SGTC_2855 9016525 58.44 µM 1.31439843789033 0.147951245963959 no 571 0.0943560779443191 130 43811474
SGTC_1001 4048-4355 44.4 µM 1.30454624150788 0.149773012402428 no 572 0.0960237019570213 146 21824233
SGTC_1173 0443-0020 122 µM 1.30445635233239 0.149789702371874 no 573 0.0960390161061132 130 5331295
SGTC_2320 7373003 200 µM 1.30281136573808 0.150095350625779 no 574 0.0963195847571535 122 5415828
SGTC_470 aa-861 153 µM 1.30229630782983 0.15019113684907 no 575 0.096407556667523 134 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_3146 9095609 49.47 µM 1.30015902943674 0.150589045503372 no 576 0.0967732347519452 113 17173999
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 1.29825202707644 0.150944674624167 no 577 0.0971003726903756 144 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 1.29670629193575 0.151233342330414 no 578 0.0973661318132831 110 6312947
SGTC_2784 7567673 72.73 µM 1.29603826569482 0.151358210524082 no 579 0.0974811509352383 130 3471247
SGTC_3046 9092212 49.47 µM 1.29233582177542 0.152051518189752 no 580 0.0981204358298913 118 25236637
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 1.2885243904373 0.15276743433687 no 581 0.0987817420608574 137 688664
SGTC_987 1497-1013 404 µM 1.28669135775634 0.153112534938336 no 582 0.0991009432583418 124 1676435
SGTC_3102 9121669 49.47 µM 1.28463396596776 0.153500490053162 no 583 0.0994601117733266 139 41905072
SGTC_832 4083-0019 164 µM 1.2837767418868 0.153662325748408 no 584 0.0996100418675459 164 1990758
SGTC_1175 0741-0056 27.6 µM 1.2802729992217 0.154324972915399 no 585 0.100224570130074 133 765927
SGTC_1402 3909-7673 35.9 µM 1.26861889054892 0.156542638431583 no 586 0.10228851174447 120 5328014
SGTC_858 0438-0351 2.77 µM 1.26828240888759 0.156606977782564 no 587 0.102348558384471 129 2799119
SGTC_2434 5670830 169.91 µM 1.26559606548258 0.157121263225721 no 588 0.102828867723322 138 1549830
SGTC_1295 1013-0063 9.78 µM 1.25937482700307 0.158316544433034 no 589 0.103947488719082 132 6826038
SGTC_1364 1653-0028 37.6 µM 1.25703421092352 0.158767785502843 no 590 0.104370623919063 119 5718652
SGTC_2728 chlorpromazine 9.18 µM 1.25214149626251 0.159713759339874 no 591 0.105259154683343 126 2726 A thorazine and dopamine antagonist.
SGTC_756 0508-1999 28.3 µM 1.24951106954839 0.160223856059398 no 592 0.105739103657917 143 6753853
SGTC_761 k216-0224 480 µM 1.24918467381347 0.16028722544927 no 593 0.105798768144155 147 1340404
SGTC_1659 st012954 42.1 µM 1.24578183048679 0.160948859371236 no 594 0.106422250918031 120 24207262
SGTC_904 1141-0088 396 µM 1.24284175070198 0.161521949025638 no 595 0.10696307699663 126 1378119
SGTC_1159 4092-0538 61.2 µM 1.24218459723416 0.161650225157417 no 596 0.107084230645184 141 717301
SGTC_2507 purpurin 79.67 µM 1.2421263772477 0.161661592880018 no 597 0.107094968926454 134 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_185 k048-0037 25.491 µM 1.23672437749594 0.162718625409236 no 598 0.108094712654406 113 6827589
SGTC_3241 9133421 49.47 µM 1.2358015118197 0.162899655102013 no 599 0.108266176451003 132 17018221
SGTC_91 0417-1751 58.384 µM 1.23504226768824 0.163048686874947 no 600 0.108407386886921 146 6795624
SGTC_1276 0871-0068 94.2 µM 1.23342566035388 0.163366305334428 no 601 0.108708498131263 156 3414906
SGTC_1788 fluconazole 20 µM 1.23327536435264 0.163395854732808 no 602 0.108736522975623 140 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_2738 aclarubicin 5.55 µM 1.2286615011915 0.164304666231713 no 603 0.109599373148096 90 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_1845 st056753 3.01 µM 1.22739532203285 0.164554642764705 no 604 0.109837021892363 119 5375839
SGTC_1661 st013063 9.66 µM 1.22694474497033 0.164643657766235 no 605 0.109921679709248 143 721395
SGTC_2894 9048625 32.47 µM 1.22493047231907 0.165041974411985 no 606 0.110300708999004 151 4092861
SGTC_799 1310-0557 151 µM 1.22447015942787 0.165133087473432 no 607 0.110387458311689 144 5354492
SGTC_1895 st058434 18.3 µM 1.22198630526042 0.165625296448918 no 608 0.110856402928075 156 5393175
SGTC_985 1493-0307 8.71 µM 1.2196040069396 0.16609827120161 no 609 0.11130751335468 139 3278274
SGTC_2995 9067767 71.4286 µM 1.21810904186673 0.166395522501995 no 610 0.111591269158168 112 11673567
SGTC_2204 7233102 200 µM 1.2163797921142 0.166739785952967 no 611 0.111920139135124 123 2172480
SGTC_2049 5262831 67.185 µM 1.2160080083194 0.166813861602255 no 612 0.11199093567705 127 763417
SGTC_2713 st079149 53.4 µM 1.21309408491896 0.167395178181002 no 613 0.112546925623488 137 3103253
SGTC_2704 st078022 71.1 µM 1.21091787025517 0.167830175147237 no 614 0.112963441495199 140 54697681
SGTC_2329 6138490 200 µM 1.21071177458476 0.167871408679035 no 615 0.113002944063139 138 720019
SGTC_3192 9110362 49.47 µM 1.20956924240505 0.168100113210652 no 616 0.113222113202008 126 16649480
SGTC_136 0097-0015 404.482 µM 1.20423160747121 0.169171220388167 no 617 0.114250036292518 147 4861337
SGTC_1575 cyproterone acetate 48 µM 1.20421948975596 0.169173657033951 no 618 0.114252377461413 152 9880 An androgen receptor antagonist and liver toxin.
SGTC_2282 7944268 200 µM 1.20294695759042 0.169429664873574 no 619 0.114498423639584 129 2970414
SGTC_1118 chelidonine 707.474 nM 1.19703348616267 0.170622596186847 no 620 0.115646751537593 126 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_2661 dactinomycin 12.96 µM 1.19491857775486 0.171050541338183 no 621 0.116059421849137 127 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_834 0312-0008 75.7 µM 1.19460260867057 0.171114535598928 no 622 0.116121164774832 137 6385573 YIL048W NEO1
SGTC_2151 5563267 85.4165 µM 1.19448925282316 0.171137497664106 no 623 0.116143321109375 157 5310824
SGTC_1645 Cervolide 78 µM 1.19314872552308 0.171409192639493 no 624 0.116405565781811 137 23173 A fragrance.
SGTC_582 0987-0078 156 µM 1.18669661407586 0.17272074580172 no 625 0.117673655541077 149 1625765
SGTC_1500 4488-1866 171 µM 1.18406995063877 0.173256508310123 no 626 0.118192686994312 148 2900003
SGTC_1325 1431-0015 227 µM 1.1818291936322 0.173714392694233 no 627 0.118636740801458 132 1103340
SGTC_2851 9015922 71.43 µM 1.17503235417811 0.175107987185811 no 628 0.119990885977034 159 2996893
SGTC_3208 9114115 49.47 µM 1.17386726793913 0.175347581497644 no 629 0.120224097460682 169 650895
SGTC_882 0843-0131 351 µM 1.1710435978614 0.175929117315401 no 630 0.120790626581518 172 5425421
SGTC_2788 5282734 71.43 µM 1.16981377978682 0.176182780139541 no 631 0.121037958531862 156 743706
SGTC_905 2-aminofluorene 215 µM 1.16937033113484 0.176274302812208 no 632 0.121127228997183 138 1539 An established DNA mutagen. YPR165W RHO1
SGTC_642 0335-0876 158 µM 1.1687323731557 0.176406022725265 no 633 0.121255737279848 162 6812350
SGTC_32 0928-0142 34.1 µM 1.16545553332654 0.177083576558984 no 634 0.12191732478067 151 2244242
SGTC_2958 9077254 16.72 µM 1.16442003006811 0.177298029497991 no 635 0.122126917096925 133 16457351
SGTC_139 0099-0334 718.624 µM 1.16340551034348 0.177508295718401 no 636 0.122332507450788 150 97690
SGTC_2922 7999257 32.47 µM 1.16338897698178 0.177511723674729 no 637 0.122335859913302 146 2988377
SGTC_1360 1598-0022 39.8 µM 1.16282041417269 0.177629632474261 no 638 0.122451186385422 169 761525
SGTC_1378 2093-0007 380 nM 1.15725575285728 0.178786242042274 no 639 0.123583942676452 160 3618014
SGTC_1464 k208-0027 110 µM 1.15527366867219 0.179199358872112 no 640 0.123989187614694 157 X1464
SGTC_2846 9008642 19.48 µM 1.15491556758903 0.179274060244915 no 641 0.124062501863621 159 2992898
SGTC_1290 0986-0249 10.2 µM 1.15437694093206 0.179386456875964 no 642 0.124172832336058 142 53329
SGTC_635 k038-0028 24.7 µM 1.15303456640868 0.179666766421268 no 643 0.124448098463469 170 4035102
SGTC_154 3389-1638 511.116 µM 1.15294352198618 0.179685787932758 no 644 0.124466783390273 152 5238686
SGTC_3000 9075062 71.4286 µM 1.15227017542626 0.179826506555971 no 645 0.124605034317069 141 17057871
SGTC_1176 0848-0131 83.3 µM 1.15214164489242 0.179853375240293 no 646 0.124631436289768 145 6769040
SGTC_668 1682-0499 62.6 µM 1.15191540538833 0.179900675635877 no 647 0.12467791855267 144 682214
SGTC_900 1112-0045 141 µM 1.15064599227595 0.180166219534238 no 648 0.124938951809838 147 56211 YIL048W NEO1
SGTC_2255 7941087 197.44 µM 1.14946634374676 0.180413206337125 no 649 0.125181868539222 142 935561
SGTC_1130 3454-2858 15.9 µM 1.1478940184294 0.180742739223113 no 650 0.125506158908837 179 715628 YIL048W NEO1
SGTC_3244 9134489 49.47 µM 1.14735088973109 0.180856657478212 no 651 0.125618314725813 164 16584271
SGTC_217 ketoconazole 989 nM 1.14679789267252 0.180972691794289 no 652 0.125732580184203 156 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_740 k014-0057 261 µM 1.14418452839256 0.181521679971382 no 653 0.126273559024215 166 4012779
SGTC_2335 9018011 154.17 µM 1.14375926305296 0.181611113769007 no 654 0.126361744204296 154 6458208
SGTC_2685 mycophenolic acid 18.85 µM 1.14364538797835 0.181635066509863 no 655 0.126385365200188 137 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_3115 9123671 49.47 µM 1.14211568034102 0.181957020294464 no 656 0.126702969239771 164 3286988
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 1.13767645029652 0.182893352930035 no 657 0.127627805235362 159 688662
SGTC_397 arbidol 50 µM 1.1316659788609 0.184165877746206 no 658 0.128887444905847 145 131410 A RNA synthesis inhibitor.
SGTC_440 fluspirilene 35.1 µM 1.13104488339909 0.184297688246118 no 659 0.129018100356208 163 3396 An atypical antipsychotic.
SGTC_986 1493-0483 84 µM 1.13077450697482 0.184355086571243 no 660 0.129075006212044 157 40079
SGTC_733 4069-0007 56.1 µM 1.12986040143796 0.184549224773816 no 661 0.129267525959879 160 5717425 YNL287W SEC21
SGTC_1771 st048882 4.1505 µM 1.12946423566142 0.184633402142268 no 662 0.129351024215671 167 4580403
SGTC_11 0438-0307 1.3 µM 1.12850484922978 0.184837351620242 no 663 0.129553385042472 165 4011476
SGTC_2691 st077356 60.2 µM 1.12791285337231 0.184963269849536 no 664 0.129678362515095 161 2839272
SGTC_1165 k072-0275 30.3 µM 1.1204762399405 0.186549583723738 no 665 0.131255436065992 148 6153523 YGL055W OLE1
SGTC_1115 galangin 695.678 nM 1.11217820742455 0.188329560482146 no 666 0.133030767942933 181 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 1.11036649435955 0.188719572572153 no 667 0.133420565102993 137 688667
SGTC_2892 9047358 58.44 µM 1.10834371174655 0.18915560987692 no 668 0.13385670214367 143 6466771
SGTC_2973 9094665 17.96 µM 1.10680205285668 0.189488350900689 no 669 0.134189760247688 186 25237061 YIL048W NEO1
SGTC_2620 irigenin 100 µM 1.10654244462509 0.189544418363305 no 670 0.134245901643149 172 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_2107 5363541 170.161 µM 1.10434366420211 0.190019697125706 no 671 0.134722044281949 161 244052
SGTC_1329 1447-1697 50.6 µM 1.10432389382224 0.190023973924643 no 672 0.134726330778611 153 2840515
SGTC_1717 st033143 58.0435 µM 1.10276603006327 0.190361162545264 no 673 0.135064391836499 149 674616
SGTC_500 h-89 112 µM 1.10162689218438 0.190607953349896 no 674 0.135311956042774 165 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_2800 7887935 81.82 µM 1.10110422903379 0.190721252454246 no 675 0.135425648334681 161 2961002
SGTC_1172 0370-0043 85 µM 1.10097185680319 0.190749953698628 no 676 0.135454452988464 144 376585
SGTC_698 k064-0052 127 µM 1.09517939986175 0.192008481705162 no 677 0.136719024394726 167 5088751
SGTC_447 ml7 120 µM 1.09306614953334 0.192468890189796 no 678 0.137182378543394 149 4216 Selective myosin light chain kinase inhibitor.
SGTC_529 4076-0302 30.3 µM 1.09203339502737 0.192694139109403 no 679 0.137409211474977 164 5816522
SGTC_1632 st005650 90 µM 1.09175415466076 0.192755070483807 no 680 0.137470587445539 152 2759605
SGTC_442 cape 100 µM 1.08960256492485 0.193224950736725 no 681 0.137944126372826 149 5281787
SGTC_2248 tofa 1.1 µM 1.08940348694401 0.193268462182604 no 682 0.137987997203804 173 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2439 5492030 7.2 µM 1.08602833073847 0.194007062436232 no 683 0.138733229137184 161 5722370
SGTC_491 tetrandrine 80.3 µM 1.08563247977048 0.194093800785978 no 684 0.138820812007144 149 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_2131 toluylene red 5.2905 µM 1.07612293571905 0.196184613996383 no 685 0.140936139667517 148 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_1506 4226-2149 212 µM 1.07393239382844 0.196668165239108 no 686 0.141426491661728 161 991114
SGTC_934 2950-0684 338 µM 1.07228069743472 0.197033245976065 no 687 0.141796986980971 174 1121253
SGTC_1857 st056007 79.3 µM 1.07078843674008 0.197363438480753 no 688 0.142132283680513 154 619834
SGTC_1281 0884-0031 11.8 µM 1.06919517349713 0.197716348976137 no 689 0.142490866552576 169 1548255
SGTC_1509 1326-1131 80 µM 1.06712448556528 0.198175579309628 no 690 0.142957813172331 151 768313
SGTC_1833 st055984 71 µM 1.06700631113548 0.198201807053435 no 691 0.142984493031334 151 676288
SGTC_796 1234-0020 70.7 µM 1.06674088766977 0.198260723024429 no 692 0.143044429093474 156 46495034
SGTC_1333 1482-0047 286 µM 1.06657983036729 0.198296478020508 no 693 0.143080806195951 170 3811116
SGTC_1764 st044502 93.5 µM 1.06603017211969 0.198418532391662 no 694 0.143205001456357 157 8407
SGTC_991 3996-0057 64.7 µM 1.06419770470086 0.198825768322819 no 695 0.143619573301281 153 715343
SGTC_97 0535-0701 19.132 µM 1.06351667729967 0.198977243862597 no 696 0.143773853118708 156 2832013 YGL099W LSG1
SGTC_1005 4092-0690 4.4 µM 1.06257145012315 0.199187598476998 no 697 0.143988169947384 174 1529343
SGTC_2885 9057732 51.95 µM 1.06181556938006 0.199355911532549 no 698 0.144159710133455 198 6471414
SGTC_472 calcifediol 10 µM 1.06169732461703 0.199382249008212 no 699 0.144186557153503 144 5283731 A vitamin D metabolite.
SGTC_1780 st038448 24.544 µM 1.06075885046277 0.199591356146733 no 700 0.14439975365033 165 728868 YDL195W SEC31
SGTC_2807 7945238 51.95 µM 1.06046622572371 0.199656584627804 no 701 0.144466273674878 176 17148797
SGTC_404 fumagillin 50 µM 1.05961315995498 0.199846813249284 no 702 0.144660312068104 176 12015870 A methionine aminopeptidase binder.
SGTC_899 1083-0020 478 µM 1.05881924450358 0.200023949597136 no 703 0.144841053771622 192 767123
SGTC_873 0591-4978 488 µM 1.05693015875083 0.200445816839497 no 704 0.145271731596563 192 3305145
SGTC_110 0850-0284 111.64 µM 1.05668672913997 0.200500217946776 no 705 0.14532729180402 141 3906265
SGTC_822 1487-0950 154 µM 1.05367119967795 0.201174856747172 no 706 0.146016739536454 171 1958375
SGTC_848 0368-0089 85.6 µM 1.05327034681785 0.20126463854016 no 707 0.146108552688886 174 762535
SGTC_638 3970-0837 4.09 µM 1.0531391728482 0.201294023699045 no 708 0.146138605788029 141 4118451 YLR208W SEC13
SGTC_772 k072-0172 35.3 µM 1.05166847562342 0.201623660468509 no 709 0.146475839582431 144 5861980
SGTC_2970 9090938 41.86 µM 1.05052363094618 0.201880485518939 no 710 0.146738716063894 180 17217104
SGTC_151 3013-0144 2.285 µM 1.04982226277664 0.202037921395196 no 711 0.146899918801904 198 906558 YHR107C CDC12
SGTC_2683 piperine 63.03 µM 1.04491461276531 0.203141594341116 no 712 0.148031217718594 190 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_3 0833-0587 95.581 µM 1.04395461417675 0.203357906894702 no 713 0.14825319420376 178 5382644
SGTC_2163 5671233 125 µM 1.04358576321892 0.203441055106277 no 714 0.148338541265106 173 701023
SGTC_1300 1094-0077 113 µM 1.04213573696731 0.203768123746141 no 715 0.148674375987813 177 5532636
SGTC_3037 9091026 49.47 µM 1.0413717254706 0.203940580575011 no 716 0.148851529895148 176 25236398 YIL048W NEO1
SGTC_90 0870-0863 4.608 µM 1.03938624144117 0.204389161342846 no 717 0.149312570109776 193 1738164
SGTC_2174 5790901 200 µM 1.03716464471756 0.204891782737669 no 718 0.149829566036702 171 786020
SGTC_179 1273-0063 6.77 µM 1.03639427953842 0.205066244168563 no 719 0.15000911901411 160 3108139
SGTC_2492 derrusnin 100 µM 1.03588494810009 0.205181638832278 no 720 0.150127910267366 193 1715307 Part of coumarin class of compounds.
SGTC_611 3453-1652 23.7 µM 1.03345714011291 0.205732215620177 no 721 0.150695009025808 193 1560575
SGTC_2184 6075246 200 µM 1.03156473666533 0.206161981124171 no 722 0.15113803350366 178 2267320
SGTC_3198 9112019 49.47 µM 1.03049574944608 0.20640498357523 no 723 0.151388673277397 196 45595555
SGTC_80 0159-0065 512.242 µM 1.02699153976002 0.207202750578205 no 724 0.15221222392094 144 1548079
SGTC_65 0798-0905 34.986 µM 1.023297226087 0.208045768168015 no 725 0.153083667448887 171 3602145
SGTC_1862 st057513 3.81 µM 1.020024664492 0.208794233128111 no 726 0.153858381707173 176 5393163
SGTC_2791 5663188 71.43 µM 1.01753074314096 0.20936567973758 no 727 0.154450507477498 198 54690634
SGTC_597 k018-0003 82.8 µM 1.01478851274914 0.209995083993447 no 728 0.155103325337364 199 6786234
SGTC_2723 salbutamol 83.58 µM 1.01447666138025 0.21006673131927 no 729 0.15517768015861 170 9884233 β2-adrenoceptor agonist
SGTC_3042 9091578 49.47 µM 1.0084910933898 0.211444686483445 no 730 0.156609380690667 171 25236497
SGTC_2467 5474540 200 µM 1.00814087572518 0.211525474701675 no 731 0.156693418412261 188 5413519
SGTC_2009 4012297 12.05 µM 1.0059639287051 0.212028058060799 no 732 0.157216461017499 169 45595307
SGTC_2369 9071472 200 µM 1.00513398989453 0.212219846549046 no 733 0.15741616757731 164 17296037
SGTC_3177 9107506 49.47 µM 1.00505627182582 0.21223781141479 no 734 0.157434877259062 166 8897194
SGTC_2703 st077852 53.4 µM 1.00481691205399 0.212293146039704 no 735 0.15749250940098 192 6281836
SGTC_2718 lomofungin 53.02 µM 1.00184587564267 0.212980684750274 no 736 0.158209018292803 181 5351222 A RNA synthesis inhibitor.
SGTC_2346 9031566 143.75 µM 1.00183439464011 0.212983344129857 no 737 0.158211791247298 174 4771086
SGTC_102 gallobenzophenone 83.616 µM 1.00170972010604 0.213012224119424 no 738 0.158241905375998 175 70837
SGTC_1004 4084-0029 199 µM 0.997987542256066 0.213875492612362 no 739 0.159142699778534 158 716894 YLR208W SEC13
SGTC_3035 9091303 49.47 µM 0.997398315420526 0.214012335941866 no 740 0.1592856043544 186 25237002
SGTC_1105 epirubicin 18.1 µM 0.996553267330716 0.214208680689935 no 741 0.159490699631821 187 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_568 1193-0097 7.48 µM 0.995621545652148 0.21442528525351 no 742 0.159717031088605 191 3646150
SGTC_544 k015-0020 52.4 µM 0.993175712924046 0.214994492585408 no 743 0.160312165972252 194 3008304
SGTC_3158 9100007 49.47 µM 0.990921326918375 0.215519921684027 no 744 0.160861998789878 163 19297233
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 0.990838221704229 0.215539305215171 no 745 0.160882291212541 181 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_61 0978-8327 98.565 µM 0.989937763702113 0.215749393626206 no 746 0.161102269930083 177 6150059 YHR072W ERG7
SGTC_2003 4023581 200 µM 0.988705377094652 0.216037117554505 no 747 0.161403655612131 159 16641307
SGTC_950 1165-0508 94.1 µM 0.986235320087952 0.216614467723388 no 748 0.162008825439347 189 6148369
SGTC_559 1550-0661 158 µM 0.985736765154572 0.216731107922019 no 749 0.162131151610235 184 5830875
SGTC_1398 3558-0053 112 µM 0.981350356004978 0.217758901564555 no 750 0.163209999177269 167 4532369
SGTC_2749 bexarotene 57.39 µM 0.980835835513138 0.217879644491161 no 751 0.163336851680322 186 82146 An retinoic acid receptor inhibitor.
SGTC_1995 st072814 61.1 µM 0.979745487360972 0.218135644911478 no 752 0.163605883296322 177 5769371
SGTC_1913 st060213 96.1 µM 0.979685780905992 0.218149668262036 no 753 0.163620623522676 206 688959
SGTC_37 0566-0070 1.56 µM 0.979109999242674 0.218284929684326 no 754 0.163762815754135 185 1626686
SGTC_1369 1866-0067 208 µM 0.978254327170745 0.218486031608979 no 755 0.16397427647968 174 3531355
SGTC_1830 st055982 50.3 µM 0.978186380889824 0.218502005063796 no 756 0.163991075512975 189 455313 An antimicrobial agent.
SGTC_2158 5657123 3.6195 µM 0.977653312754836 0.218627347097666 no 757 0.164122909980518 196 2858827
SGTC_64 000l-0018 272.079 µM 0.975423758619292 0.219152037746994 no 758 0.164675051619983 214 6811119
SGTC_1965 Pectolinarigenin 58.4 µM 0.975200195959697 0.219204689624434 no 759 0.164730482479578 177 5320438 An anti-inflammatory.
SGTC_550 4123-0385 25.7 µM 0.97518301403739 0.219208736488688 no 760 0.16473474312193 181 5731123
SGTC_1237 0330-0133 46.1 µM 0.97258974533669 0.21982002222349 no 761 0.165378620639345 215 X1237 YHR072W ERG7
SGTC_3001 9076041 71.4286 µM 0.971584049788948 0.220057347998255 no 762 0.165628760365083 185 16004211
SGTC_2852 9023854 51.95 µM 0.970504313502462 0.220312309576074 no 763 0.165897587936007 213 19798528
SGTC_321 4534-3890 65.3 µM 0.969912340776818 0.220452165834424 no 764 0.166045094094764 203 699746
SGTC_2897 9048598 12.99 µM 0.968851821384194 0.22070284556888 no 765 0.16630956327259 164 6467404
SGTC_1218 1348-1416 30.7 µM 0.964787452132297 0.221665069270697 no 766 0.16732564103318 198 6787668
SGTC_1148 3909-7663 27.7 µM 0.964667688671467 0.221693459118354 no 767 0.167355642025605 177 4084526
SGTC_1463 k081-0032 34.1 µM 0.964451609345162 0.221744685832219 no 768 0.167409779108398 181 977755
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.960497946699866 0.222683188171089 no 769 0.168402331947866 194 4213774
SGTC_3254 9136651 49.47 µM 0.960275416934036 0.222736078483429 no 770 0.168458309516423 209 16454030
SGTC_2414 st077232 92.9 µM 0.956867869088947 0.223546869515827 no 771 0.169316975355484 164 729801
SGTC_92 0063-0024 660.874 µM 0.954695296474978 0.224064685990467 no 772 0.169865904578585 202 3594437
SGTC_718 1130-0073 349 µM 0.953830843710863 0.22427091119099 no 773 0.170084636991658 180 6740020
SGTC_707 0865-0008 204 µM 0.95270544467094 0.22453954953927 no 774 0.170369666963334 205 723043
SGTC_881 0833-0569 170 µM 0.951599439403848 0.224803736285491 no 775 0.17065008297878 178 5418700
SGTC_326 k292-0812 17.5 µM 0.951308326464923 0.224873302476216 no 776 0.170723940697244 192 3579357
SGTC_2956 9076196 2.52 µM 0.95104536488833 0.224936151928682 no 777 0.170790673771474 207 16423868
SGTC_1318 1280-3875 124 µM 0.948520573035075 0.225540099377369 no 778 0.171432252242389 218 373245
SGTC_306 1672-3436 11.6 µM 0.948131344254661 0.225633287138371 no 779 0.171531296589399 196 6797378
SGTC_2490 carminic acid 95.39 µM 0.947633283966853 0.225752562718267 no 780 0.171658087854777 188 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_270 tamoxifen 5.46 µM 0.947012189137756 0.225901352593392 no 781 0.171816283899883 210 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_2974 9094440 9.66 µM 0.94699757193672 0.225904854967175 no 782 0.171820008097163 179 25236134
SGTC_767 0929-0023 86 µM 0.945691563663634 0.226217906708344 no 783 0.172152963342767 212 1204563
SGTC_424 splitomicin 100 mM 0.944899720837067 0.226407831674386 no 784 0.17235503703809 189 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_272 doxorubicin 8.13 µM 0.944613398836797 0.226476528696681 no 785 0.172428141985195 205 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1014 4130-3005 69.3 µM 0.943899755310199 0.226647803866682 no 786 0.172610438542736 191 743608
SGTC_1568 digitonin 820 nM 0.943716234992231 0.226691860743383 no 787 0.172657337717834 215 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_2474 5321570 43.32 µM 0.943327705745977 0.226785149113346 no 788 0.172756654350753 195 2841384
SGTC_2929 9013348 24.6 µM 0.941782416715288 0.227156397257386 no 789 0.173152024605908 178 2995952
SGTC_2376 9072922 81.32 µM 0.941385453648374 0.227251820969825 no 790 0.173253682638446 187 17087968
SGTC_60 0986-0278 202 µM 0.940419783794175 0.227484047190908 no 791 0.173501139087557 199 3110598
SGTC_583 1488-1091 88.9 µM 0.939604937994146 0.227680106871169 no 792 0.173710121215731 228 4303273
SGTC_2475 5812728 15.03 µM 0.938750247555272 0.227885855726808 no 793 0.173929494227584 192 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_2207 7258803 200 µM 0.938601699682998 0.227921626189679 no 794 0.173967639905271 206 3666799
SGTC_2627 acetyl isogambogic acid 100 µM 0.937084846099726 0.228287066674063 no 795 0.174357457884557 186 6857789 A caspase activator and apoptosis inducer.
SGTC_2771 fluoxetine 41.05 µM 0.934606172401515 0.228884937124426 no 796 0.174995648445368 190 3386 A selective serotonin reuptake inhibitor.
SGTC_2132 5317594 122.667 µM 0.934233434140273 0.22897491969963 no 797 0.175091746372182 217 794577
SGTC_710 3448-4187 58 µM 0.932966994356734 0.229280798599121 no 798 0.175418504981646 206 3946412
SGTC_2802 7925815 54.55 µM 0.931054574817444 0.229743132676372 no 799 0.175912667224126 189 1262923
SGTC_968 1309-0633 340 µM 0.931007132972509 0.229754608539934 no 800 0.175924937219542 208 3761976
SGTC_1243 0416-0003 5.65 µM 0.930462154391045 0.229886458218363 no 801 0.176065925175852 185 2141977
SGTC_2343 7990716 14.84 µM 0.930197464740929 0.229950511326492 no 802 0.176134427159086 210 6456862
SGTC_2061 5245884 80.95 µM 0.930026483329909 0.229991892983433 no 803 0.176178686310762 214 573863
SGTC_1682 st012968 530 nM 0.929661589535904 0.230080220086417 no 804 0.176273163917049 179 24207270
SGTC_3089 9117425 49.47 µM 0.929102715987322 0.230215539202753 no 805 0.176417928536546 182 9401657
SGTC_112 phenothiazine 287.218 µM 0.927865972561764 0.230515148010394 no 806 0.176738548594948 196 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_1038 k292-0204 154 µM 0.927863978302474 0.230515631308069 no 807 0.176739065894824 190 4454212
SGTC_1630 st005209 31.3 µM 0.926671957679382 0.230804612210773 no 808 0.177048440749935 211 3367314
SGTC_347 4534-1311 26.2 µM 0.924881335986717 0.231239091640953 no 809 0.177513818015604 190 2862016
SGTC_3297 9117502 71.43 µM 0.924380089776351 0.231360796546313 no 810 0.17764422861187 169 7453720
SGTC_735 3076-0345 636 µM 0.921350050602987 0.232097264307788 no 811 0.178433848967998 212 2888990
SGTC_1238 0333-0287 48.8 µM 0.920912894241902 0.232203625190581 no 812 0.178547953024412 204 7226
SGTC_801 0866-0028 10.1 µM 0.919169649817144 0.232628029139912 no 813 0.179003421608496 204 6849771
SGTC_937 3122-0005 46.7 µM 0.919028763743109 0.232662347573902 no 814 0.17904026371424 216 759535
SGTC_3103 9120822 49.47 µM 0.918396954120282 0.232816284661259 no 815 0.179205542378669 228 17141819
SGTC_530 4358-1714 28 µM 0.91782773063302 0.232955021411956 no 816 0.179354530928626 214 1564641
SGTC_627 1391-0720 175 µM 0.910014638643965 0.23486393883973 no 817 0.181407394882141 233 997839
SGTC_589 1227-0070 34.1 µM 0.909149117092431 0.235075936204215 no 818 0.181635709399418 201 2841384
SGTC_3193 9111931 49.47 µM 0.906441890269765 0.235739715330518 no 819 0.182351004476006 225 17087244
SGTC_1768 st044301 37.178 µM 0.905387758806158 0.235998454857542 no 820 0.182629999256416 252 3931349
SGTC_3355 9151058 44.0485 µM 0.903943400332408 0.236353230668569 no 821 0.183012707175447 204 17015728
SGTC_2450 5739737 12.93 µM 0.902850769746773 0.236621806993929 no 822 0.183302550860335 213 2262825
SGTC_1511 0906-3109 28.5 µM 0.902664920237875 0.236667506820518 no 823 0.183351879895559 199 2882180
SGTC_932 2857-0803 154 µM 0.900481881176793 0.237204672763658 no 824 0.183931931678734 198 674898
SGTC_2750 bromebric acid 70.15 µM 0.900108696970627 0.237296566710486 no 825 0.18403120410089 196 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_2235 salicylic acid 500 µM 0.899448112414228 0.23745927886559 no 826 0.184207010961417 202 338 A COX inhibitor and kinase inhibitor.
SGTC_3238 9133470 49.47 µM 0.8966254177695 0.238155241567785 no 827 0.184959415133377 176 3534688
SGTC_2596 sinensetin 100 µM 0.89544106634743 0.238447587407951 no 828 0.185275678166428 210 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_1208 2323-2347 50.3 µM 0.895382622054961 0.238462018909075 no 829 0.185291293515048 200 5412760
SGTC_2481 5478948 45.16 µM 0.893180934449963 0.239006024238613 no 830 0.185880143181208 206 77792
SGTC_517 1365-0151 113 µM 0.89083082455366 0.239587450440845 no 831 0.186509967893158 198 768657
SGTC_3344 9148862 3.898 µM 0.887133810808918 0.240503666377424 no 832 0.18750343131469 217 4905352
SGTC_1514 1189-1591 158 µM 0.884348977381098 0.241195078284032 no 833 0.188253928445974 228 767698 YMR146C TIF34
SGTC_2149 5554786 194.827 µM 0.883627788756931 0.24137430926687 no 834 0.18844858649979 199 745063 YPR165W RHO1
SGTC_1307 1187-1599 12.2 µM 0.883135262164113 0.241496754355121 no 835 0.188581597051273 225 1538471
SGTC_516 3992-2719 87.3 µM 0.882987429833619 0.241533512947347 no 836 0.188621531587762 171 5350887 YDR037W KRS1
SGTC_72 0744-0168 198.391 µM 0.882106467507475 0.241752627716078 no 837 0.188859617542721 221 677577
SGTC_2982 9019404 25.97 µM 0.875630584246021 0.243366629104246 no 838 0.190615446587453 199 22333232
SGTC_3052 9092717 49.47 µM 0.873435885335462 0.243914937838104 no 839 0.191212769211211 228 25237534
SGTC_2426 5582046 32.21 µM 0.866558246989001 0.245637509398518 no 840 0.193092049483232 207 2251934
SGTC_3307 9126885 69.2785 µM 0.866206563181706 0.245725767277625 no 841 0.193188447413078 192 24824909
SGTC_2827 7993847 71.43 µM 0.863113963015674 0.246502612813465 no 842 0.19403740580321 192 2985692
SGTC_2952 9073731 13.78 µM 0.862487832691955 0.246660053608128 no 843 0.194209562880864 230 16457353
SGTC_419 nsc-638432 893 µM 0.862073070282767 0.246764375476251 no 844 0.194323654696523 212 368090
SGTC_1202 1988-0068 29.6 µM 0.858314062385825 0.247710924905265 no 845 0.195359533232074 211 2850480
SGTC_1018 4259-0013 28.1 µM 0.857895219416908 0.247816512970629 no 846 0.195475162111993 221 6801262
SGTC_189 3970-0742 2.116 µM 0.857454943295011 0.247927530116847 no 847 0.195596752785921 215 2891807
SGTC_2370 9071495 200 µM 0.857309019637726 0.247964331127052 no 848 0.195637062525842 223 21791103
SGTC_1627 st003713 25.6 µM 0.852938854344516 0.249067808376471 no 849 0.196846606747147 216 16195070 YER133W GLC7
SGTC_2805 7950783 58.44 µM 0.85154181919473 0.249421113381452 no 850 0.197234221588077 204 1178958 YDL195W SEC31
SGTC_1457 k015-0032 57.3 µM 0.849476794550493 0.249943837911989 no 851 0.197808018669242 224 4302660
SGTC_3184 9108758 49.47 µM 0.848539416892521 0.250181310231308 no 852 0.198068815147396 233 902885
SGTC_3223 9129970 49.47 µM 0.847919962377604 0.250338306540082 no 853 0.198241273183039 235 17248386
SGTC_495 decylubiquinone 155 µM 0.847889935048652 0.250345918078473 no 854 0.198249635186091 217 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_2531 methyl deoxycholate 70.07 µM 0.846308374157603 0.250746996596347 no 855 0.198690368733777 224 16667744 Haematoxylin.
SGTC_2455 5377712 9.75 µM 0.845863011807449 0.250860000356029 no 856 0.198814584385932 212 2243908
SGTC_1968 st069590 43.6 µM 0.844126707582883 0.251300817811578 no 857 0.19929930244425 236 6384066
SGTC_1381 2324-0066 62.1 µM 0.843901907845498 0.251357920485981 no 858 0.199362111002382 225 10885928
SGTC_1271 0832-2808 169 µM 0.842582451572031 0.251693221394781 no 859 0.199731004425357 244 3663794
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 0.841393107926954 0.251995660319239 no 860 0.200063872624812 227 688669
SGTC_3058 9093861 49.47 µM 0.836965812426942 0.253123163387501 no 861 0.201305892570928 222 17217477
SGTC_3216 9129716 49.47 µM 0.836950532732562 0.253127059269727 no 862 0.2013101870779 212 8056934
SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.836631746531614 0.253208347767179 no 863 0.201399797570807 214 94937 An inhibitor of serotonin biosynthesis.
SGTC_2150 5556613 200 µM 0.834772194197132 0.253682795496219 no 864 0.201922992228395 233 743190
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.832589175916796 0.254240367768708 no 865 0.202538232818289 259 5393153
SGTC_34 0469-0683 81.75 µM 0.830550386662662 0.254761681705681 no 866 0.203113836096654 202 3690923
SGTC_3026 9090633 49.47 µM 0.83038791440161 0.254803249569336 no 867 0.203159748221839 242 25236842
SGTC_171 k064-0041 9.68 µM 0.83011602110749 0.254872820298546 no 868 0.20323659488041 213 53325
SGTC_2407 paclitaxel 400 µM 0.829674291580692 0.254985869087304 no 869 0.203361480246275 226 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_213 1246-0773 967 nM 0.828504042024348 0.255285489750172 no 870 0.203692553389267 216 6251622
SGTC_187 1488-2104 32.728 µM 0.827647613487973 0.255504878947225 no 871 0.203935047529575 226 2852859
SGTC_2358 9037157 4 µM 0.827414215514788 0.255564685008709 no 872 0.204001163001955 248 2388925
SGTC_2984 9022109 38.96 µM 0.825897326427757 0.255953551861343 no 873 0.204431168681959 265 6459207
SGTC_181 1447-1644 8.07 µM 0.822947728976385 0.25671058805368 no 874 0.205268859501056 246 534600
SGTC_134 0269-0018 6.916 µM 0.822662020569717 0.256783979126814 no 875 0.205350109374885 229 4378915
SGTC_1911 st060208 74.3 µM 0.822532663428676 0.256817211209907 no 876 0.205386902293115 235 688783
SGTC_2365 9042475 200 µM 0.819963109142356 0.257477797908053 no 877 0.206118568980582 240 6464479
SGTC_918 glabranin 770.725 nM 0.818340442461179 0.257895410897372 no 878 0.206581409613366 207 124049 Also referred to as licorice root.
SGTC_2883 9059145 45.46 µM 0.817823140774755 0.25802861861277 no 879 0.206729091240885 254 16476510
SGTC_1311 1190-0148 100 µM 0.816792189885995 0.258294199899667 no 880 0.207023598128559 237 1961333
SGTC_2705 st078069 42.8 µM 0.815676856913431 0.258581678146876 no 881 0.207342489437472 211 1530061
SGTC_1076 itraconazole 331 nM 0.814831714955621 0.2587996246625 no 882 0.207584322168265 233 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_3206 9114350 49.47 µM 0.813160794491235 0.2592308038146 no 883 0.208062937115448 218 17087243
SGTC_1923 st058458 19.1 µM 0.812906160047841 0.259296544533959 no 884 0.208135931222283 265 3534982
SGTC_159 3970-0959 50 µM 0.810925492161191 0.259808201110653 no 885 0.208704229910505 238 6615653
SGTC_8 0354-0001 70 µM 0.810795005554669 0.25984192738017 no 886 0.2087417015694 227 4993152
SGTC_2004 4023728 41.89 µM 0.810091998823023 0.260023669135771 no 887 0.20894365125637 262 360084 YDR527W RBA50
SGTC_622 1348-1566 26.3 µM 0.809399517681859 0.260202753869716 no 888 0.209142689775234 228 7340407
SGTC_396 dithiazanine 1.25 µM 0.808374976781366 0.260467830175334 no 889 0.209437376267038 206 10578 An antihelmenthic.
SGTC_1835 st008666 49.2 µM 0.807940894398591 0.260580180897545 no 890 0.209562304092944 213 690455
SGTC_1280 0880-0253 10.1 µM 0.807246221863748 0.260760030370733 no 891 0.209762320289065 240 6836607
SGTC_1203 3992-3522 103 µM 0.804634346201702 0.261436811351496 no 892 0.210515358056986 249 5322312
SGTC_3044 9093193 49.47 µM 0.804110782765686 0.261572583902753 no 893 0.210666498886991 244 25236277
SGTC_955 1216-0110 33 µM 0.802175015701027 0.26207488881519 no 894 0.211225863262775 227 3619719
SGTC_2739 tacrine 100.86 µM 0.800612969980295 0.262480578313151 no 895 0.211677869900586 216 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_1386 3228-0095 33.8 µM 0.800113804931377 0.262610287606009 no 896 0.211822431756923 233 870181
SGTC_2751 anetholtrithion 17.25 µM 0.800106730463464 0.262612126159984 no 897 0.211824480989726 232 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_2743 auranofin 4.32 µM 0.799352025672082 0.262808301067733 no 898 0.212043159921069 192 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_2803 7707263 71.43 µM 0.798462640465055 0.263039580422041 no 899 0.212301032462365 210 2199229
SGTC_2694 st077685 81.9 µM 0.797339959071393 0.26333167552367 no 900 0.212626809563971 220 2838096
SGTC_1248 0469-0687 58.6 µM 0.796758694355125 0.263482971882156 no 901 0.21279559426122 228 4017482
SGTC_1207 2099-0101 141 µM 0.796009322867847 0.263678089902139 no 902 0.213013308321533 241 5837381
SGTC_884 0851-0618 334 µM 0.794985686351454 0.263944738887193 no 903 0.213310914209908 253 9642473
SGTC_3023 9089636 49.47 µM 0.79448215970663 0.264075953895559 no 904 0.213457395409336 244 17249241
SGTC_484 loperamide 105 µM 0.793641846375505 0.264295006804622 no 905 0.21370198191656 199 3955 An opioid-receptor agonist.
SGTC_1949 st076024 69.1 µM 0.792368310121869 0.264627168549787 no 906 0.21407297583732 260 2921930
SGTC_1866 st057638 64 µM 0.792060640267908 0.264707446357043 no 907 0.214162659344285 219 688802
SGTC_1841 st054148 70 µM 0.791598746484551 0.26482798781508 no 908 0.214297339033986 243 675442
SGTC_1009 4106-0057 9.87 µM 0.790170799584106 0.26520081872139 no 909 0.214714013404427 243 2928005
SGTC_429 1112-0049 25.5 µM 0.789257331441976 0.265439461101477 no 910 0.214980809799377 240 2836170
SGTC_117 lucigenin 22.078 µM 0.787954207637149 0.265780089020859 no 911 0.215361745843558 232 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_2323 6148992 148.28 µM 0.787801096759291 0.265820125730186 no 912 0.215406529722062 236 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_1783 st039459 87.517 µM 0.785742869903817 0.266358624620959 no 913 0.21600907117468 259 729761
SGTC_1700 st030840 7.9285 µM 0.780639518239163 0.267696203813261 no 914 0.217507271099037 260 5499307
SGTC_1134 3477-0009 42.5 µM 0.779410583319404 0.268018810410447 no 915 0.217868945751129 237 3973534
SGTC_452 diindolylmethane 8 µM 0.779000430318946 0.268126522852653 no 916 0.217989730631485 229 3071 Inhibits expression of several cancer promoting factors.
SGTC_2325 6158266 200 µM 0.778564647926531 0.268240989831123 no 917 0.218118105335273 241 3623240
SGTC_2630 antimycin a 100 µM 0.776226065294746 0.268855685116538 no 918 0.218807759263389 262 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_2899 9053889 58.44 µM 0.774956973593839 0.26918956108739 no 919 0.219182542215855 234 6470052
SGTC_1685 st024049 53.0905 µM 0.774620027208249 0.269278240756078 no 920 0.219282109802787 245 1941139
SGTC_3111 9122088 49.47 µM 0.773159189282429 0.269662882650972 no 921 0.219714087664166 240 16876704
SGTC_190 3970-0790 3.722 µM 0.770725546241529 0.270304276887487 no 922 0.220434813251647 238 2832352
SGTC_1339 1486-1321 22.7 µM 0.770093919961121 0.270470868544792 no 923 0.220622091182065 239 3469382
SGTC_2298 7976326 193.81 µM 0.768299593960766 0.270944402382066 no 924 0.221154607919929 218 2235818
SGTC_1739 st037196 92.5 µM 0.768222570159526 0.270964738700007 no 925 0.22117748334979 238 612214
SGTC_3109 9122853 49.47 µM 0.767771290876744 0.271083903650005 no 926 0.221311536748821 273 1234709
SGTC_1104 tacrolimus 29.8 µM 0.767444743233496 0.271170148220002 no 927 0.221408567338883 247 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_2830 7992007 71.43 µM 0.765258879937501 0.271747809115972 no 928 0.222058702294725 251 1952075
SGTC_53 0973-0023 39.979 µM 0.764919985750136 0.271837423925576 no 929 0.222159596094037 254 674768
SGTC_23 0213-0011 39.996 µM 0.761657353696996 0.272700923023507 no 930 0.223132267207222 253 627608
SGTC_1902 st060212 70.5 µM 0.760392522190305 0.273036043291534 no 931 0.223509995885914 237 688944
SGTC_2354 9060492 162 µM 0.75978531118774 0.273196997859862 no 932 0.223691462233862 251 6471895
SGTC_2308 7584454 197.62 µM 0.759611946609031 0.273242960561996 no 933 0.223743287989113 251 893577
SGTC_695 3505-6186 243 µM 0.759355073751725 0.273311070158478 no 934 0.223820090329106 261 1819379
SGTC_1534 6-azauridine 81.6 µM 0.758950212735708 0.273418435743599 no 935 0.223941170020323 252 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_3020 9089140 49.47 µM 0.758588979081833 0.273514249360465 no 936 0.224049233713429 247 17217859
SGTC_1812 st052057 4.327 µM 0.757415257301886 0.273825682011909 no 937 0.224400559101076 248 3645418
SGTC_161 4065-0411 162.148 µM 0.755354173658462 0.274372989188929 no 938 0.225018250906365 244 1906281 YLR208W SEC13
SGTC_770 0389-1121 67.2 µM 0.75521161247423 0.274410865329391 no 939 0.225061011057162 230 6753108
SGTC_546 peri-Naphthalide 147 µM 0.75478468032215 0.274524309550478 no 940 0.225189093670083 242 223824 A penicillin ester.
SGTC_2594 a-mangostin 100 µM 0.754472169821289 0.274607364367089 no 941 0.22528287516052 261 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_3314 9135860 59.4275 µM 0.753209502169266 0.274943065262629 no 942 0.22566201510407 251 25252478
SGTC_1366 1683-0113 21.9 µM 0.751642949324768 0.275359839890216 no 943 0.226132903753882 254 708623
SGTC_961 1252-1571 372 µM 0.751347227188474 0.275438550357797 no 944 0.226221856858466 261 6813498
SGTC_2747 doxorubicin 7.63 µM 0.75082689113143 0.275577071741348 no 945 0.226378421730682 201 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1888 azatryptophan 97.5 µM 0.749715036354064 0.2758731791774 no 946 0.226713174767073 214 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_125 0133-0007 11.75 µM 0.747132982064232 0.276561430276049 no 947 0.227491646509598 254 26541
SGTC_670 4204-0025 119 µM 0.745693166892883 0.276945580736345 no 948 0.227926393930466 238 719039
SGTC_224 benfluorex 43.875 µM 0.74380763895705 0.277449044517416 no 949 0.228496429038643 264 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_1436 4092-1007 8.32 µM 0.742270260658046 0.277859878042187 no 950 0.22896180324353 223 2881121
SGTC_813 k007-0158 173 µM 0.73683548565595 0.279314588710604 no 951 0.230611200306704 254 6523916
SGTC_226 1,3-diallylurea 8.28947 mM 0.736704064784347 0.279349811532217 no 952 0.230651167204215 261 74537 YKL182W FAS1
SGTC_3274 9138298 49.47 µM 0.735995514802569 0.279539751032813 no 953 0.230866713680457 270 17015756
SGTC_3075 9116269 49.47 µM 0.735510867086463 0.279669705627697 no 954 0.231014212083926 253 17015205 YNL244C SUI1
SGTC_957 1187-1561 14.1 µM 0.735212603618092 0.279749697277785 no 955 0.231105012170778 255 1538454
SGTC_1987 st072290 61.9 µM 0.733998680883909 0.280075375207795 no 956 0.231474771021246 256 54697379
SGTC_233 rapamycin 362 pM 0.733874451450449 0.280108714532346 no 957 0.231512629696357 265 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_106 0092-0003 11.579 µM 0.733696158475748 0.280156566194222 no 958 0.231566970160847 247 1072148
SGTC_1428 4049-0204 61.7 µM 0.733601939340688 0.280181855061587 no 959 0.231595689315119 271 X1428
SGTC_1293 1000-1278 195 µM 0.732553612599909 0.28046330557277 no 960 0.231915366127664 279 678847
SGTC_844 0330-0132 15.3 µM 0.731185881534549 0.280830714093087 no 961 0.232332811318597 253 2828079
SGTC_630 4356-0227 183 µM 0.729459414561232 0.281294820512705 no 962 0.232860342624406 276 779312
SGTC_1827 berberine 7.24 µM 0.726572616929858 0.282071671556187 no 963 0.233743903970541 237 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_3242 9133940 49.47 µM 0.726255925656011 0.282156957533889 no 964 0.233840946566707 259 17248444
SGTC_2736 butenafine 14.65 µM 0.725761552389572 0.282290118652035 no 965 0.233992480252599 263 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1955 wogonin 32.4 µM 0.725615183207075 0.282329549489378 no 966 0.234037355292685 245 5281703 A flavanone.
SGTC_1377 2944-0135 198 µM 0.725170405858958 0.282449385663945 no 967 0.234173747951827 239 1894137
SGTC_2848 9016370 25.97 µM 0.722233043253994 0.283241411659179 no 968 0.23507560550754 245 7894410
SGTC_2748 diazoxide 86.69 µM 0.721538877491024 0.283428740970399 no 969 0.235289014946847 206 3019 A potassium channel activatior.
SGTC_2398 5228213 48.84 µM 0.719378737139549 0.284012061520202 no 970 0.235953797103409 268 80771 YMR134W ERG29
SGTC_825 1988-2224 89.6 µM 0.718137710930945 0.284347445662203 no 971 0.236336190016154 263 1180859
SGTC_478 N-arachidonylglycine 10 µM 0.717913213835838 0.284408135635146 no 972 0.23640539991859 222 5283389
SGTC_1072 oxiconazole 14.9 nM 0.715697058904032 0.285007577186572 no 973 0.237089213628118 247 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1574 spiramycin 23.7 µM 0.715560261572951 0.285044598847538 no 974 0.237131459209772 278 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_1287 0971-0001 34.6 µM 0.715523019691811 0.285054678069141 no 975 0.237142960917381 258 4665869
SGTC_784 4579-0127 173 µM 0.71524251673662 0.285130599442408 no 976 0.237229600732866 261 1948547
SGTC_2466 5983409 37.09 µM 0.71505398671322 0.285181632692 no 977 0.237287842353169 253 2879657
SGTC_2819 7996655 46.38 µM 0.713495487111718 0.285603670063917 no 978 0.237769602351294 249 6456960
SGTC_926 2268-1401 59.4 µM 0.713160617284101 0.285694390663689 no 979 0.237873186559888 278 2931578
SGTC_2294 7971431 200 µM 0.711602375627854 0.286116718857775 no 980 0.238355517771859 288 5741572
SGTC_2077 5212015 200 µM 0.710554601186566 0.286400862454979 no 981 0.238680142148515 261 780900
SGTC_3061 glucosamine 200 µM 0.709416569448026 0.286709634375 no 982 0.239033004195358 251 91431 and experimental redox chemotherapeutic
SGTC_1200 1643-0193 18.4 µM 0.70913510598701 0.286786025663363 no 983 0.239120319695405 281 5403974
SGTC_309 k408-0051 1.48 µM 0.709081950910178 0.286800453431731 no 984 0.239136811402156 270 3640463
SGTC_2686 alizarin 95.37 µM 0.708924591969038 0.286843167047871 no 985 0.239185636676319 248 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_2444 5485484 36.41 µM 0.705604414871663 0.287745100225465 no 986 0.240217088990042 284 6790631
SGTC_1450 4112-4260 37.6 µM 0.704733834049658 0.287981816896987 no 987 0.240487945799883 277 1633175
SGTC_876 0720-0963 56.8 µM 0.703360830681623 0.288355332287135 no 988 0.240915455065838 271 765861
SGTC_371 0195-0006 7.36 µM 0.703271264112257 0.288379706142464 no 989 0.240943357582172 257 3928593
SGTC_234 nsc-17383 10.7 µM 0.703217897679774 0.28839422927394 no 990 0.240959983568946 246 408974
SGTC_385 1494-0393 12.4 µM 0.69762530400287 0.289918104574261 no 991 0.242705776332338 266 3090647
SGTC_473 2-arachidonoylglycerol 10 µM 0.697437745101693 0.289969276182111 no 992 0.242764443443788 270 5282280 An endocannabinoid.
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.697426700660964 0.289972289563766 no 993 0.242767898306823 307 6728940
SGTC_1368 1852-0141 284 µM 0.69613604467089 0.290324535137276 no 994 0.243171817636085 273 2838987
SGTC_384 k007-0144 5.16 µM 0.695765727957729 0.290425638882995 no 995 0.243287777747723 281 6824886
SGTC_340 k038-0059 454 µM 0.693099228013377 0.291154131987339 no 996 0.244123641053044 274 23733424
SGTC_2463 5473429 200 µM 0.693041108349638 0.291170019892987 no 997 0.244141876956912 256 5399405
SGTC_577 r071-0003 38.6 µM 0.692410318423003 0.291342482073213 no 998 0.244339843865216 293 4568517 YMR134W ERG29
SGTC_3317 9138495 8.753 µM 0.692071232844196 0.291435210031409 no 999 0.244446298117724 277 17020139
SGTC_1474 0330-0125 5.35 µM 0.691842521219154 0.291497762376318 no 1000 0.244518115119139 275 X1474
SGTC_2274 7947094 46.08 µM 0.691199698503903 0.291673607113883 no 1001 0.244720026664316 267 2971028
SGTC_155 k072-0202 43.6 µM 0.691153674871389 0.291686198816875 no 1002 0.244734486196669 283 5857737
SGTC_3308 9128332 17.569 µM 0.690727102338928 0.2918029177537 no 1003 0.244868527041998 251 17332805 YDL196W YDL196W
SGTC_637 1181-0519 7.26 µM 0.689144043970268 0.292236264888153 no 1004 0.245366312808096 271 6252091 YGR060W ERG25
SGTC_284 0988-0104 32.6 µM 0.688525129449243 0.292405768202918 no 1005 0.245561075545326 280 4666532
SGTC_483 fpl-64176 144 µM 0.688144082397564 0.292510149023552 no 1006 0.245681026393639 280 3423
SGTC_439 amiodarone 34.4 µM 0.684474657191823 0.293516205636615 no 1007 0.246837743514407 284 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_2226 7298446 200 µM 0.683761401384549 0.293711946849742 no 1008 0.247062921885504 281 3283010
SGTC_2363 9053361 176 µM 0.683676038434812 0.293735377341092 no 1009 0.247089878750224 277 6469797 YMR079W SEC14
SGTC_1141 3253-0389 52.6 µM 0.680004587939367 0.294743937616947 no 1010 0.248250777946772 287 5402031
SGTC_999 SEC7.066 22.7 µM 0.678414718917235 0.295181175095912 no 1011 0.248754389603756 281 740511 YDR170C SEC7
SGTC_12 0849-0099 9.267 µM 0.676506385384163 0.29570638900475 no 1012 0.24935959665277 279 6071388
SGTC_1267 0828-0272 9.49 µM 0.673588203263395 0.296510364048711 no 1013 0.250286577578381 280 745334
SGTC_2264 7948757 110.76 µM 0.672669689604015 0.296763626646639 no 1014 0.250578727451369 271 2971411
SGTC_3292 9120825 59.784 µM 0.672341004478712 0.296854279346135 no 1015 0.250683315571402 285 24824900
SGTC_180 1486-1293 102.781 µM 0.671205489138654 0.297167556589056 no 1016 0.251044816156716 274 4140536
SGTC_301 4119-0100 24.5 µM 0.670133874719521 0.297463342752503 no 1017 0.251386226164069 296 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_1187 1391-0724 117 µM 0.668203965726834 0.297996373507068 no 1018 0.252001702184851 280 6997986
SGTC_1217 1183-1422 255 µM 0.666637019808044 0.298429475715121 no 1019 0.252502008270371 273 2849664
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.66583045003046 0.298652522368411 no 1020 0.252759739725123 270 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_692 k241-0027 77.8 µM 0.665309649281649 0.298796583478736 no 1021 0.252926230057462 275 3600480
SGTC_1452 4194-0072 190 µM 0.665190992052114 0.298829410222028 no 1022 0.252964170642502 291 1343545
SGTC_2992 9074591 71.4286 µM 0.663351347616583 0.299338560794777 no 1023 0.253552778911825 288 17741321
SGTC_1838 st055369 84.5 µM 0.663136725389522 0.299397986497408 no 1024 0.253621495768732 266 676036
SGTC_878 0828-0289 13.7 µM 0.663134826621965 0.299398512261778 no 1025 0.253622103751924 287 745350 YLR208W SEC13
SGTC_2074 5212007 75.395 µM 0.662986900129582 0.299439474054102 no 1026 0.253669471997958 272 758611
SGTC_749 1000-0129 128 µM 0.660949790264686 0.300003821040224 no 1027 0.254322256899138 285 708470
SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.660865031254021 0.300027312521892 no 1028 0.254349436703885 294 165506
SGTC_1114 scopoletin 1.73284 µM 0.660858278079907 0.300029184241472 no 1029 0.254351602320295 281 5280460 A coumarin with genotoxic properties.
SGTC_401 neomycin 50 µM 0.659832938000386 0.300313430261184 no 1030 0.254680521775079 268 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_1317 1273-0028 910 nM 0.659493236914244 0.300407629441515 no 1031 0.25478954379093 283 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_1446 4239-0190 62 µM 0.659185638501859 0.30049293805866 no 1032 0.254888284004307 278 1340085
SGTC_1951 sophoraflavanone G 9.2 µM 0.65818178870163 0.300771419480115 no 1033 0.255210662727513 278 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_1624 st003710 6.25 µM 0.655602394744471 0.301487511439699 no 1034 0.256039992149653 295 24207033
SGTC_1054 3429-0080 167 µM 0.654756258759588 0.30172258291685 no 1035 0.256312348565248 295 1162877
SGTC_1916 st067606 49.2 µM 0.654556351785587 0.30177813262703 no 1036 0.25637671717932 267 19590279
SGTC_1397 3532-0190 20.1 µM 0.653512092743453 0.302068383732881 no 1037 0.256713098002733 255 5322280
SGTC_1792 st045773 43.6 µM 0.649502997199411 0.303183871708593 no 1038 0.258006654897158 246 2919270
SGTC_1600 coumarin 106 71.1 µM 0.648833013984346 0.303370466877456 no 1039 0.258223157932232 312 100336 A hepatotoxic, DNA x-linker.
SGTC_361 000s-0510 1.45 µM 0.647559772472802 0.303725215194282 no 1040 0.258634861438175 285 660
SGTC_2212 7123476 200 µM 0.646688130099731 0.303968177358343 no 1041 0.258916903428409 268 1085715
SGTC_3330 9141424 71.43 µM 0.645713143948242 0.304240048261961 no 1042 0.259232573338523 271 27261020
SGTC_1848 st056003 16.4 µM 0.644384147435314 0.304610807833512 no 1043 0.259663180829356 270 146492
SGTC_1167 k781-0610 148 µM 0.644371072821093 0.304614456349366 no 1044 0.259667418961834 280 4525169
SGTC_1562 morin hydrate 59.1 µM 0.643701816620958 0.304801240538108 no 1045 0.259884405850641 288 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_432 NS 1619 61.3 µM 0.642418588260163 0.3051595218696 no 1046 0.260300716840631 282 4552 A K+/calcium channel activator.
SGTC_2533 agelasine 13.65 µM 0.641311721812899 0.305468712483322 no 1047 0.260660087480788 286 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_3076 9116187 49.47 µM 0.640490843377825 0.30569810524027 no 1048 0.260926770098168 279 27241210
SGTC_2671 danthron 100 µM 0.638792332918979 0.306172992534367 no 1049 0.261479018340968 291 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_2990 9074105 71.4286 µM 0.638301817372867 0.306310196673526 no 1050 0.261638614600814 305 6502001
SGTC_1710 st031758 61.5 µM 0.637159039509595 0.306629953154332 no 1051 0.262010627557845 293 5394341
SGTC_1305 1181-0477 144 µM 0.636905999665198 0.306700775223958 no 1052 0.262093037263229 305 6252086
SGTC_1155 4088-0394 48.2 µM 0.635858585360504 0.306994007575027 no 1053 0.262434299112001 296 2326248
SGTC_1736 st036774 51 µM 0.635173269326243 0.307185934355264 no 1054 0.26265770747118 291 1272247
SGTC_2035 5154463 94.595 µM 0.633748252746714 0.307585187713192 no 1055 0.263122564510033 300 2769623
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.63283357353376 0.307841577727643 no 1056 0.263421164894435 293 2724278 An inhibitor of dopamine biosynthesis.
SGTC_2782 7736369 71.43 µM 0.632128519754417 0.308039272548353 no 1057 0.26365145029227 300 2950836 YOL077C BRX1
SGTC_319 1348-1596 45.5 µM 0.630723572204986 0.308433381429632 no 1058 0.264110641749517 312 5380505
SGTC_2060 5238662 140 µM 0.628615039468312 0.309025270890704 no 1059 0.264800555945875 301 790130
SGTC_3202 9113761 49.47 µM 0.628013687463903 0.309194168334241 no 1060 0.264997486755908 293 4798415
SGTC_1515 3460-0031 42.1 µM 0.627584273972053 0.309314799321341 no 1061 0.265138156652581 290 2876596
SGTC_1434 4073-0095 163 µM 0.622659201209742 0.310699819715626 no 1062 0.266754249326617 298 24133745
SGTC_1073 triclabendazole 3.09 µM 0.622086753280433 0.310860977203073 no 1063 0.266942412433247 286 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_2817 7995342 71.43 µM 0.619770527797402 0.31151341907254 no 1064 0.267704437410653 294 18879975
SGTC_3219 9131112 49.47 µM 0.619542956461802 0.311577554089735 no 1065 0.267779366184387 283 17612988 YMR079W SEC14
SGTC_2196 6573537 42.6665 µM 0.616886246221095 0.312326700776848 no 1066 0.268654879642218 313 2903087
SGTC_2101 5377231 179.231 µM 0.616735525099834 0.312369224849128 no 1067 0.268704592563359 320 2844213
SGTC_3072 9116419 49.47 µM 0.613017317779001 0.3134190604706 no 1068 0.269932444501425 287 17170162
SGTC_2421 5690543 90.72 µM 0.611812143803704 0.313759666477291 no 1069 0.270331027096255 307 3397993
SGTC_44 0929-0055 61.211 µM 0.6103527074589 0.314172344631083 no 1070 0.270814094463531 289 1379590
SGTC_128 0906-2981 13.371 µM 0.609975153785796 0.31427914162317 no 1071 0.27093913327626 310 6740226
SGTC_2824 7998404 51.95 µM 0.60802922421839 0.31482982483208 no 1072 0.271584045746801 320 837851
SGTC_1947 st076332 61.6 µM 0.606295304571917 0.315320858033623 no 1073 0.272159338010489 307 24208416
SGTC_1142 3253-1408 9.78 µM 0.605740558742539 0.315478026903386 no 1074 0.272343523369359 303 256655
SGTC_1268 0828-0275 2.46 µM 0.603943359068536 0.315987433133036 no 1075 0.272940650165464 314 745337
SGTC_1931 st074438 57.1 µM 0.600093102986272 0.317079942617561 no 1076 0.274222094411008 321 2787313
SGTC_409 arachidonic acid 100 µM 0.600011894637417 0.31710300269489 no 1077 0.274249154178387 304 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_1449 4112-4002 201 µM 0.596761261845256 0.318026641009533 no 1078 0.27533339237595 300 2059539
SGTC_467 ro 31-8220 72.8 µM 0.593847312529747 0.31885557711414 no 1079 0.276307120600403 318 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_1820 st053765 18.6 µM 0.592580247453126 0.319216304463596 no 1080 0.276731050737569 300 3690829
SGTC_2746 daunorubicin 9.88 µM 0.592433483517082 0.319258098523529 no 1081 0.276780175080375 279 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1660 st012960 28.1 µM 0.590683685018653 0.319756566581862 no 1082 0.277366190745249 323 24207266
SGTC_2698 st077697 67.5 µM 0.589863675351757 0.319990276266968 no 1083 0.277641024412652 298 3154499
SGTC_4 0960-0234 25.671 µM 0.587628205970759 0.320627766659498 no 1084 0.278390937216543 286 6821112
SGTC_3134 9127454 49.47 µM 0.585861704348036 0.321131895799366 no 1085 0.278984226995542 323 24262820
SGTC_1296 1068-0102 11.9 µM 0.582517049741595 0.322087305523131 no 1086 0.280109230304794 314 767053
SGTC_1772 st048439 82.2 µM 0.582189934465027 0.322180810177774 no 1087 0.280219376254898 286 2927068 YDL195W SEC31
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.579142720115898 0.32305238488439 no 1088 0.281246438321162 325 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_6 0844-0013 19.835 µM 0.577973483278351 0.323387072444497 no 1089 0.281641010951139 320 1584900
SGTC_2059 5238311 157 µM 0.577169702160566 0.323617233271073 no 1090 0.281912411010752 305 703021
SGTC_346 4513-0042 7.16 µM 0.574030541585807 0.324516770307955 no 1091 0.282973567003812 308 2827372
SGTC_2014 4013930 200 µM 0.572343679180706 0.325000570069269 no 1092 0.28354458182894 322 64556
SGTC_3169 9102970 49.47 µM 0.571345746010854 0.325286920867174 no 1093 0.283882648984623 319 17027839
SGTC_531 3788-1495 174 µM 0.571157175017743 0.325341041752988 no 1094 0.283946552342408 320 2896655
SGTC_1409 3909-8004 61.9 µM 0.57008026062571 0.32565019251832 no 1095 0.284311631339372 305 2119279
SGTC_1581 himbacine 57.9 µM 0.569914054776255 0.325697916068895 no 1096 0.284367995875192 327 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_869 0564-0080 44.1 µM 0.569050349694723 0.32594596218538 no 1097 0.284660985683997 292 6843321
SGTC_1171 0368-0077 21.4 µM 0.568308381490808 0.326159108409182 no 1098 0.284912794398851 325 3239779
SGTC_3114 9122766 49.47 µM 0.56760275107385 0.3263618685269 no 1099 0.285152369346521 279 17176985
SGTC_1779 st039427 55 µM 0.566696871984826 0.326622244543446 no 1100 0.285460073207635 345 1124498
SGTC_856 0433-0016 11.3 µM 0.566420466822248 0.326701708258307 no 1101 0.285553992410751 305 3911780
SGTC_1874 staurosporine 7.6 µM 0.565471133211684 0.326974692014089 no 1102 0.285876676693652 314 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_855 0428-0020 25 µM 0.564363574895053 0.327293290815143 no 1103 0.286253361499942 299 6812414
SGTC_2257 7960413 200 µM 0.563654291838003 0.327497388392326 no 1104 0.286494715104048 316 2974689 YIL048W NEO1
SGTC_511 blebbistatin 171 µM 0.563111452138839 0.327653626408673 no 1105 0.286679496852625 322 3476986 A myosin inhibitor.
SGTC_2210 7115885 190.385 µM 0.562269116178892 0.327896124021696 no 1106 0.286966338469434 325 2927039
SGTC_3092 9117248 49.47 µM 0.562205032075024 0.327914575977466 no 1107 0.286988166665825 347 17141857
SGTC_280 3448-3607 3.04 µM 0.561891263405726 0.328004926529332 no 1108 0.287095053259074 314 626179
SGTC_2322 7413319 38.22 µM 0.56131601088055 0.328170598218554 no 1109 0.287291064351833 311 1840400
SGTC_1051 3253-3903 78 µM 0.561235867939424 0.328193681924631 no 1110 0.287318377219408 310 5509239
SGTC_898 1000-0849 28.3 µM 0.55956526664959 0.328675017291496 no 1111 0.287888000871638 319 6751807
SGTC_274 sirtinol 40.1 µM 0.55932374516505 0.328744628257394 no 1112 0.287970396371291 292 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_555 4296-0685 37 µM 0.557718267230032 0.329207507675033 no 1113 0.28851839090164 340 2908540 YHR072W ERG7
SGTC_2068 5226020 147 µM 0.557156922530381 0.329369412230041 no 1114 0.288710109425799 322 1810509
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.555995394257762 0.329704524931201 no 1115 0.289107001667093 340 688798
SGTC_680 0417-1641 114 µM 0.554286856827184 0.330197703820263 no 1116 0.289691271855825 315 2835990
SGTC_1495 4469-0029 237 µM 0.551937838030308 0.330876243011479 no 1117 0.290495471586435 323 793680
SGTC_2720 fluspirilene 36.88 µM 0.550150941656276 0.331392779625343 no 1118 0.291107924423688 314 3396 An atypical antipsychotic.
SGTC_1103 duloxetine 36.1 µM 0.546913636875582 0.332329401373666 no 1119 0.292219033240889 320 60835 A selective serotonin reuptake inhibitor.
SGTC_3021 9087658 49.47 µM 0.546787193890918 0.332366005347699 no 1120 0.29226247105134 324 25237042
SGTC_1711 st032263 62.8 µM 0.546766612298559 0.332371963663281 no 1121 0.292269541868662 334 3958979
SGTC_3162 9099653 49.47 µM 0.545460965183104 0.332750031517652 no 1122 0.292718260193766 295 25237511
SGTC_2476 5806916 10.51 µM 0.545123067919854 0.332847901987587 no 1123 0.292834439142764 314 2870194
SGTC_2391 6285546 200 µM 0.544535501928218 0.333018115036774 no 1124 0.293036512451828 321 846083
SGTC_782 0083-0095 30.5 µM 0.541109202153079 0.334011370389538 no 1125 0.294216157946335 315 3591729 An indicator and reagent.
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.540888473033077 0.334075397872298 no 1126 0.294292228241 309 688664
SGTC_1343 1487-0095 224 µM 0.539588121531371 0.334452692267988 no 1127 0.294740555117232 353 4560101 YGL055W OLE1
SGTC_1688 st021091 57.6 µM 0.537556871328094 0.335042390082644 no 1128 0.295441506074821 341 3656366
SGTC_2606 farnesol 9.78 µM 0.533818319897992 0.336128801948024 no 1129 0.296733618825324 331 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_2023 5144124 124 µM 0.533228485684578 0.33630033138052 no 1130 0.296937712555294 327 2830192
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.53314482739077 0.336324662773378 no 1131 0.296966665098045 330 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_1162 k048-0130 20.1 µM 0.532007970057139 0.336655377199312 no 1132 0.297360237729053 348 6797406
SGTC_1606 st000094 49.2 µM 0.531858989788093 0.336698725274471 no 1133 0.297411831385469 320 1242210
SGTC_3293 9120939 62.045 µM 0.530571228319698 0.337073509442333 no 1134 0.297857968959016 338 934087
SGTC_2516 gossypol 71.55 µM 0.529059877785688 0.337513572286069 no 1135 0.298381956580893 326 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.528457847009582 0.337688928694605 no 1136 0.29859079838678 323 4330530
SGTC_1440 4100-1550 40 µM 0.526731833517984 0.338191868225091 no 1137 0.299189912992231 334 742806
SGTC_857 0438-0306 1.35 µM 0.522054027788206 0.339556374702567 no 1138 0.300816356886756 312 4686136
SGTC_1346 1488-2224 62.4 µM 0.520864130340281 0.33990380204899 no 1139 0.301230712279622 337 3722427
SGTC_526 4469-0568 170 µM 0.520087874069866 0.340130527400141 no 1140 0.301501164791243 340 2901964
SGTC_3093 9117344 49.47 µM 0.519518920635141 0.340296741420369 no 1141 0.301699461069031 319 24824913
SGTC_1523 st012844 44.7 µM 0.516696412530125 0.341121767057453 no 1142 0.302684050383367 319 4274103
SGTC_202 3594-0513 34.79 µM 0.515927339108395 0.341346700944125 no 1143 0.302952579382948 326 708429
SGTC_752 1896-0090 130 µM 0.514674323100497 0.341713296114686 no 1144 0.303390309555416 334 772567
SGTC_3051 9093778 49.47 µM 0.512511162515515 0.342346523770767 no 1145 0.304146655019974 362 17217378
SGTC_13 0199-0087 65 µM 0.511697750085518 0.342584750949612 no 1146 0.304431280506649 334 4589825
SGTC_1964 st076914 61 µM 0.511424517588093 0.342664787642452 no 1147 0.304526915341917 361 24208661
SGTC_1225 1216-0074 20.6 µM 0.510994831463847 0.342790667837758 no 1148 0.304677337961141 325 4241466
SGTC_2033 5192550 145 µM 0.510647148284443 0.342892537352598 no 1149 0.304799077530091 302 182073
SGTC_1636 st007707 68.9 µM 0.507949259178251 0.343683393719221 no 1150 0.305744464036834 377 403051
SGTC_1872 amphotericin b 148 nM 0.506727853545216 0.344041660631552 no 1151 0.306172892101981 342 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_167 3672-0051 66.205 µM 0.50601329280932 0.344251323006783 no 1152 0.306423659014123 351 3237971
SGTC_929 2805-0021 398 µM 0.50513651800209 0.344508646730018 no 1153 0.306731476993926 361 3098024
SGTC_3078 9116413 49.47 µM 0.50347448475655 0.344996632595913 no 1154 0.307315357494834 326 17177322
SGTC_2867 9039098 71.43 µM 0.503036386320613 0.345125304682878 no 1155 0.307469345093162 352 6463460
SGTC_1634 st006576 41 µM 0.503036234171018 0.345125349373221 no 1156 0.307469398578252 347 3915356
SGTC_888 0916-0002 6.97 µM 0.502692741812932 0.34522624762917 no 1157 0.307590156751874 323 2802138 YIL048W NEO1
SGTC_1209 2323-2347 50.3 µM 0.501500931620545 0.34557641804243 no 1158 0.308009311176067 328 5412760
SGTC_2362 9071156 126 µM 0.49928792058308 0.346226981882136 no 1159 0.308788281811998 336 653133
SGTC_2411 st077133 39.94 µM 0.493425420223848 0.347952584475524 no 1160 0.310856012273715 351 1403142 YNL221C POP1
SGTC_1059 3448-6867 171 µM 0.493401926246861 0.347959506197751 no 1161 0.310864310792424 336 3934407
SGTC_663 1486-0733 13.9 µM 0.492432587483133 0.34824513390363 no 1162 0.311206783469057 345 722445 YPR165W RHO1
SGTC_2357 9067248 200 µM 0.491937617660766 0.348391016125015 no 1163 0.311381722088658 357 9150235
SGTC_2296 7971656 126.45 µM 0.489555769457461 0.349093330441492 no 1164 0.312224140781058 335 666570
SGTC_2639 lactacystin 53 µM 0.48621939863888 0.350077965547167 no 1165 0.313405809491666 325 3870 A proteasome inhibitor.
SGTC_1766 st045414 44.774 µM 0.485374534253616 0.350327463612612 no 1166 0.313705346573222 359 253960
SGTC_2717 st081029 62.2815 µM 0.484435597247238 0.350604818182843 no 1167 0.314038380167431 355 5292846
SGTC_1749 st037932 54.2 µM 0.484237461002266 0.350663356246401 no 1168 0.314108676907695 375 594497
SGTC_3278 9139605 49.47 µM 0.482244703277758 0.351252300507532 no 1169 0.314816061940028 350 7958859
SGTC_1468 k284-1086 134 µM 0.480485342489325 0.351772563212387 no 1170 0.315441161578605 342 15996457
SGTC_247 mechlorethamine 29.705 µM 0.48030337710626 0.351826388278083 no 1171 0.315505843941189 343 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_2417 cerulenin 830 nM 0.4801854295462 0.351861278561852 no 1172 0.315547773215014 345 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_2449 5812982 45.77 µM 0.47992281358531 0.351938967950977 no 1173 0.315641139305744 352 776185
SGTC_3148 9097893 49.47 µM 0.478542677919493 0.352347353497936 no 1174 0.316132002997263 298 17174100
SGTC_1414 3917-0015 5.4 µM 0.476229152688298 0.353032313126396 no 1175 0.316955566247192 356 6618702
SGTC_2526 patulin 37.61 µM 0.475792400218327 0.353161674873636 no 1176 0.317111142336981 321 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.473016577976219 0.353984241993955 no 1177 0.31810067591037 349 688751
SGTC_1839 st053978 48 µM 0.472768673872717 0.354057737333281 no 1178 0.318189112848891 355 3788398
SGTC_2555 cholic acid 100 µM 0.472169877585866 0.354235282983983 no 1179 0.318402769287627 341 6708657 Influences liver metabolism.
SGTC_1408 3909-7976 48.8 µM 0.471745258629173 0.354361203519511 no 1180 0.318554314146938 347 24152374
SGTC_41 0478-0632 82.643 µM 0.47079104295684 0.354644233768846 no 1181 0.318894980758327 383 3750424
SGTC_2870 9038528 12.99 µM 0.469985132512752 0.354883337682953 no 1182 0.319182819844079 354 6463316
SGTC_448 monastrol 171 µM 0.469952575388562 0.354892998191292 no 1183 0.319194450243602 365 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.465031901303125 0.356354154000804 no 1184 0.320954305759263 388 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_2583 asiatic acid 100 µM 0.464949455618792 0.356378653646689 no 1185 0.320983826497453 367 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_2823 7987624 58.44 µM 0.462806074031572 0.357015790917354 no 1186 0.321751688527017 364 2239440
SGTC_2082 5219693 150 µM 0.457935210790906 0.358465175053021 no 1187 0.323499494552645 337 2834649
SGTC_602 3130-1533 38.1 µM 0.457299255318426 0.358654562374326 no 1188 0.323727982448455 375 720941
SGTC_1732 st034308 51.822 µM 0.455781707483094 0.359106627968432 no 1189 0.324273479734536 328 830119
SGTC_2726 cimetidine 79.27 µM 0.455097280772398 0.359310577931465 no 1190 0.324519627112529 363 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_2155 5570423 76 µM 0.455038455996954 0.359328108795935 no 1191 0.324540786447999 372 797402
SGTC_2622 2-methoxyxanthone 59.94 µM 0.455023916599667 0.359332441849251 no 1192 0.324546016372257 343 71034 A hepatoprotective.
SGTC_1483 3453-0561 55.9 µM 0.454538456679756 0.359477129736791 no 1193 0.324720659605393 356 4546991
SGTC_1053 3366-3204 134 µM 0.453224833760743 0.359868746711077 no 1194 0.325193425969569 353 3632071 YPR165W RHO1
SGTC_199 4063-0024 41.6 µM 0.450094580105836 0.360802529696286 no 1195 0.326321122335332 358 306215
SGTC_727 3032-0951 202 µM 0.45005410275986 0.360814609905163 no 1196 0.326335715021697 372 3652836
SGTC_759 3486-0358 89.3 µM 0.449041348787261 0.361116905122647 no 1197 0.326700914404423 359 875103
SGTC_1337 1486-1011 40.3 µM 0.44846880737925 0.361287840437371 no 1198 0.326907446526892 344 X1337
SGTC_327 1273-0057 3.96 µM 0.447245877503922 0.361653045449442 no 1199 0.327348770003314 357 3108138
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 0.445716164965873 0.362110042765587 no 1200 0.327901143173423 346 5355888
SGTC_3191 9110352 49.47 µM 0.445228185476661 0.362255866664726 no 1201 0.328077429954002 357 17122424
SGTC_1657 st012939 43.4 µM 0.444744351017125 0.362400471634401 no 1202 0.328252257125059 350 24207257
SGTC_1418 3966-3099 2.4 µM 0.44461884073047 0.362437986455946 no 1203 0.328297614751277 376 740335
SGTC_132 0417-1715 25.805 µM 0.444502124703646 0.362472873872835 no 1204 0.328339796528919 376 6769098
SGTC_39 0986-0283 58.349 µM 0.441944771190909 0.363237574865854 no 1205 0.329264585853242 328 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_3294 9122953 26.2835 µM 0.439127937162592 0.364080497066156 no 1206 0.330284418589663 361 16459826
SGTC_2602 kawain 100 µM 0.436645587493184 0.364823872280704 no 1207 0.331184198049723 336 5369129
SGTC_2591 skatole 100 µM 0.436610243292706 0.364834460286308 no 1208 0.331197016349466 384 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_126 0417-1624 672.48 µM 0.435914029361497 0.365043044984722 no 1209 0.331449552929635 402 41912 YDL195W SEC31
SGTC_3335 9143315 29.6265 µM 0.435709393449186 0.365104361209184 no 1210 0.331523794771969 335 4899691
SGTC_557 1315-0110 16.2 µM 0.434455087588141 0.365480271331841 no 1211 0.331979001077722 356 6833801
SGTC_2007 4011539 71.82 µM 0.430856638296838 0.366559427429258 no 1212 0.333286307011632 351 45595301
SGTC_2242 6630449 61.2675 µM 0.430573610987223 0.366644350733876 no 1213 0.333389216216998 363 691249 YDR170C SEC7
SGTC_626 0214-0009 33 µM 0.43007760613628 0.366793194416724 no 1214 0.33356959465921 370 3437874
SGTC_289 k017-0060 526 µM 0.429020745847153 0.367110409265237 no 1215 0.33395406359015 370 5512909
SGTC_2610 ononetin 44.17 µM 0.428659361994558 0.367218898853672 no 1216 0.334085569298929 350 259632
SGTC_2663 amphotericin b 100 µM 0.427716171548345 0.36750210017694 no 1217 0.334428887348163 363 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2091 4-phenylthiadiazole 200 µM 0.426541740448857 0.367854834297384 no 1218 0.334856569800304 353 270010
SGTC_2175 5807670 165.306 µM 0.426126554151319 0.367979559973786 no 1219 0.335007815911817 345 241186
SGTC_194 1486-1323 56.904 µM 0.423901797545261 0.368648133591105 no 1220 0.335818716584144 369 5178754
SGTC_960 1222-0186 7.7 µM 0.422173937318563 0.369167656756418 no 1221 0.336449031716736 376 3126296
SGTC_2950 9072895 21.46 µM 0.420487148209993 0.369675061528085 no 1222 0.337064808000061 324 17332245
SGTC_2019 4016004 108 µM 0.418370921068269 0.370311967000264 no 1223 0.337837971923557 366 45595336
SGTC_51 1013-0126 23.419 µM 0.418320087472087 0.370327270399293 no 1224 0.337856552420226 382 1627850
SGTC_1731 st035964 63 µM 0.41830184153304 0.370332763369523 no 1225 0.337863221700656 372 6739575
SGTC_1375 2910-0797 186 µM 0.417757944396237 0.370496516642478 no 1226 0.33806205108724 384 742508
SGTC_2904 7225135 42.03 µM 0.4160441712954 0.371012642465569 no 1227 0.3386888406321 395 4446116
SGTC_2029 5175081 200 µM 0.4133079743765 0.371837165811041 no 1228 0.339690494053746 350 1380876
SGTC_1683 st010134 710 nM 0.409998873192743 0.372835113225891 no 1229 0.340903387064657 362 3818134
SGTC_2770 toltrazuril 17.5 µM 0.408614651443113 0.373252815826213 no 1230 0.341411238388204 356 68591 Kills coccidiodes.
SGTC_1953 st076800 12.1 µM 0.405762906903232 0.374113827142013 no 1231 0.342458407835374 361 297591
SGTC_903 1134-0042 114 µM 0.405030323732446 0.374335113508039 no 1232 0.342727610667551 374 701009
SGTC_1850 st056238 17 µM 0.404726827409399 0.374426800691289 no 1233 0.342839160077173 374 5393177
SGTC_2168 5727979 200 µM 0.403416859226868 0.37482262757018 no 1234 0.343320793122544 354 695210
SGTC_2847 9005661 71.43 µM 0.40305605532005 0.374931673163859 no 1235 0.343453493828114 372 2991449
SGTC_975 1335-0046 28.5 µM 0.401203424576867 0.375491750186501 no 1236 0.344135179809754 378 16486740
SGTC_3122 9126309 49.47 µM 0.394632841474012 0.377480241500202 no 1237 0.346556936334064 432 17591206
SGTC_449 xestospongin c 11.1929 µM 0.392477511221565 0.378133231805737 no 1238 0.347352712306837 403 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_574 1315-0397 40 µM 0.392126600199897 0.378239578689613 no 1239 0.347482337052286 368 6794277
SGTC_542 3381-0244 89.3 µM 0.39160696702429 0.378397075350874 no 1240 0.34767431966331 416 1112843
SGTC_935 2996-0153 430 µM 0.390925312554689 0.378603710003361 no 1241 0.347926221567079 381 23738523
SGTC_2629 bisabolol 100 µM 0.388748613000303 0.379263780189491 no 1242 0.348731058680451 414 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_2861 9024595 19.48 µM 0.387294550303961 0.379704911693293 no 1243 0.349269079789272 359 16482810
SGTC_805 3852-0218 479 µM 0.387169515151193 0.379742852003096 no 1244 0.349315358500865 356 6615355
SGTC_480 am 92016 50 µM 0.385771746283425 0.380167065730014 no 1245 0.349832860921059 402 2129 K+ channel blocker.
SGTC_2772 vinpocetine 57.06 µM 0.385425547702084 0.380272157039058 no 1246 0.349961078781167 420 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_664 1222-0054 14.9 µM 0.38531578247474 0.380305478985116 no 1247 0.350001734925622 364 6813991
SGTC_913 3487-1245 167 µM 0.384687821458725 0.380496129133441 no 1248 0.35023435960744 360 4016153
SGTC_1978 st071761 42 µM 0.384545052896013 0.380539477990108 no 1249 0.350287255275209 361 5147680
SGTC_1695 st026914 34.495 µM 0.382694190154923 0.381101591529338 no 1250 0.35097326135747 367 3289191
SGTC_2806 7952793 58.44 µM 0.382290900754796 0.381224105283714 no 1251 0.351122801610262 361 2972490
SGTC_2412 st077135 33.4 µM 0.382097288786459 0.381282926158211 no 1252 0.351194601381882 401 13258915
SGTC_2655 perillic acid 100 µM 0.381784177893778 0.381378057571419 no 1253 0.351310727812759 382 5702197 An apoptosis inducer.
SGTC_387 norethindrone acetate 66.7 µM 0.380813372258478 0.381673059671015 no 1254 0.351670867988937 397 541197
SGTC_76 0433-0009 400.328 µM 0.379234272881419 0.382153052888914 no 1255 0.352256951490771 413 2841569
SGTC_1470 k295-0292 231 µM 0.378479290100197 0.382382606382157 no 1256 0.352537287848179 391 5045612
SGTC_617 3770-0098 35 µM 0.377784818740068 0.382593797804922 no 1257 0.352795226158104 378 5962639
SGTC_2276 7947513 42.08 µM 0.3766722436015 0.382932208962362 no 1258 0.353208596247626 379 2105100
SGTC_2024 5144227 134 µM 0.375499052455206 0.383289154462469 no 1259 0.353644675501023 379 3475211
SGTC_1467 k284-1082 293 µM 0.372994601297918 0.38405146943035 no 1260 0.354576231019077 389 3334705
SGTC_1351 1496-0003 46.5 µM 0.372845270185901 0.384096937645057 no 1261 0.354631803764759 373 3891978
SGTC_2565 isoliquiritigenin 100 µM 0.371126110757546 0.38462050064561 no 1262 0.355271802006864 342 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_970 1315-0089 19.5 µM 0.370232511548646 0.384892725855316 no 1263 0.355604627139455 369 6811083 YLR033W RSC58
SGTC_741 4582-0002 126 µM 0.370156260888058 0.384915957413524 no 1264 0.355633032151319 387 2912688
SGTC_1604 st002052 72.4 µM 0.369961522214327 0.384975291008202 no 1265 0.355705580135876 347 6254834 YHR062C RPP1
SGTC_1502 4534-4282 27.7 µM 0.369561421492552 0.385097203411241 no 1266 0.355854650137899 420 3278949
SGTC_2105 5350118 200 µM 0.36933254818122 0.38516694719704 no 1267 0.355939933940792 383 2133313
SGTC_644 1498-1197 63.3 µM 0.36892047118541 0.385292527382061 no 1268 0.35609350209741 386 6741615
SGTC_2349 9023730 187.07 µM 0.368067370161268 0.385552547556768 no 1269 0.356411500236298 382 4126287
SGTC_3252 9135871 49.47 µM 0.367863612612301 0.385614659274708 no 1270 0.356487466775179 395 17682838
SGTC_1056 3448-1962 115 µM 0.363625114571168 0.386907349866137 no 1271 0.358068985050755 389 715507
SGTC_2902 5787006 60.46 µM 0.363598836722645 0.386915368222668 no 1272 0.358078797785002 374 591003
SGTC_1587 estradiol valerate 56.1 µM 0.362804833031808 0.387157671256717 no 1273 0.358375340646811 412 13791 A steroid.
SGTC_2236 dapsone 200 µM 0.362713944541112 0.387185410152494 no 1274 0.358409290945693 368 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_730 1436-0052 41.2 µM 0.358464626874236 0.388482930023554 no 1275 0.35999781754078 364 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_3059 1327-0034 3 µM 0.357679330782026 0.388722855242199 no 1276 0.360291651401371 371 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_2775 cyproheptadine 69.59 µM 0.357580485253978 0.388753057733768 no 1277 0.360328642237127 414 2913 A selective serotonin reuptake inhibitor.
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.356156808038993 0.389188140274996 no 1278 0.360861568019305 365 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_791 1348-1292 225 µM 0.355210968664917 0.389477270164633 no 1279 0.361215774024626 385 5437054
SGTC_89 0302-0250 142.109 µM 0.355165194287311 0.389491264306275 no 1280 0.361232919026132 390 4203518 YLR208W SEC13
SGTC_2172 5754775 163.918 µM 0.354736237784 0.389622411839611 no 1281 0.361393600177907 378 2263357
SGTC_182 3448-4371 550.524 µM 0.354541271655177 0.389682024199781 no 1282 0.361466639867566 361 3491403
SGTC_2145 5634607 200 µM 0.353808923696819 0.389905968269933 no 1283 0.361741042695398 382 308662
SGTC_130 0136-0219 337.655 µM 0.351888710425721 0.390493322057894 no 1284 0.362460863087868 423 234244
SGTC_2037 5169046 200 µM 0.351025006768659 0.39075759285463 no 1285 0.362784793980367 367 5718022
SGTC_2339 9000433 200 µM 0.347812846589946 0.391740872032599 no 1286 0.363990370581777 365 2988954
SGTC_1988 st071872 53.4 µM 0.347538812098299 0.391824789265036 no 1287 0.36409328278237 396 16414116
SGTC_1032 k061-1018 98.7 µM 0.347237852017057 0.391916957685444 no 1288 0.364206318038629 387 4005393
SGTC_254 nsc-64875 3.808 µM 0.344453926017053 0.392769816359663 no 1289 0.365252470022002 402 56993
SGTC_1504 k297-0033 30 µM 0.344211685548924 0.392844051401565 no 1290 0.365343547434058 370 4388117
SGTC_2252 omeprazole 400 µM 0.343589235706274 0.393034820182673 no 1291 0.365577610534774 417 4594 A proton pump inhibitor.
SGTC_165 k038-0023 64.381 µM 0.343453820427787 0.393076325738259 no 1292 0.365628538090134 391 46368543
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.343268598596098 0.393133099254891 no 1293 0.365698200941895 399 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2601 securinine 100 µM 0.341693070008637 0.393616116281658 no 1294 0.366290943944915 406 442872 A GABA receptor antagonist.
SGTC_747 3448-8087 38.7 µM 0.340282180841845 0.394048798047792 no 1295 0.366822017488874 399 5168703
SGTC_708 3448-5400 146 µM 0.339741666862433 0.394214593834002 no 1296 0.367025540261302 399 3462195
SGTC_3229 9132204 49.47 µM 0.338998518380755 0.394442576467364 no 1297 0.367305423155885 403 17682924
SGTC_1258 0671-0043 57.1 µM 0.33877935205091 0.394509819087661 no 1298 0.367387978553016 401 4298767
SGTC_1774 st048371 48.465 µM 0.338531272893119 0.394585936271651 no 1299 0.367481432206998 391 4242727
SGTC_3002 9075603 71.4286 µM 0.33822484322027 0.394679962477951 no 1300 0.367596877860286 400 20105405
SGTC_2625 euphol 100 µM 0.338190138741329 0.394690611737271 no 1301 0.367609953331754 424 6708538 A triterpene alcohol.
SGTC_1037 k284-1091 78.7 µM 0.337715739934963 0.394836191494347 no 1302 0.367788706104885 383 3334711
SGTC_3221 9128209 49.47 µM 0.337206019115844 0.394992626956587 no 1303 0.367980800078258 395 16460723
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.335687196196587 0.395458860376889 no 1304 0.368553381038254 397 23847180
SGTC_2117 5521686 200 µM 0.332332116315345 0.396489299598273 no 1305 0.369819245685897 389 803312
SGTC_1132 3456-3614 2.5 µM 0.331541376966198 0.396732263457999 no 1306 0.370117796107308 384 3125502
SGTC_3323 9138564 53.9225 µM 0.330835638337479 0.396949143724906 no 1307 0.370384319892316 377 43912313 YNL103W MET4
SGTC_2900 5328528 85.29 µM 0.330492918592918 0.397054476300564 no 1308 0.370513771234156 407 795359
SGTC_2916 7875993 68.79 µM 0.330224977419686 0.397136831423643 no 1309 0.370614987593807 418 1299250
SGTC_3085 9117376 49.47 µM 0.328403225466957 0.397696891458509 no 1310 0.371303402269904 400 16480349
SGTC_2201 6605497 169.863 µM 0.326445267903632 0.39829906024707 no 1311 0.37204374642675 409 670741
SGTC_2853 9015042 58.44 µM 0.325267587864155 0.39866137188678 no 1312 0.372489279696331 375 6457456
SGTC_1722 st034304 3.6505 µM 0.324934425030027 0.398763884838301 no 1313 0.372615350980242 408 4036148 YLR033W RSC58
SGTC_2489 cantharidin 73.42 µM 0.323984512368585 0.399056207717003 no 1314 0.372974879859183 401 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_331 k048-0133 24.5 µM 0.32354740198923 0.399190741604577 no 1315 0.373140357322079 390 6813582
SGTC_717 1532-0246 73.2 µM 0.323334153676357 0.399256379544004 no 1316 0.373221095518056 367 9561992
SGTC_3269 9137823 49.47 µM 0.32309394078233 0.399330320606374 no 1317 0.373312049473384 411 17682936
SGTC_2745 rifampicin 24.3 µM 0.322048285782892 0.399652230641674 no 1318 0.373708057359774 417 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_2238 6671620 73.2395 µM 0.321731686192285 0.399749710848322 no 1319 0.373827985500468 352 729941
SGTC_2684 capsaicin 100 µM 0.32156647072105 0.399800582752218 no 1320 0.373890574085215 422 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.320413552753301 0.400155627871798 no 1321 0.374327426534859 429 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_3120 9124077 49.47 µM 0.31919512661558 0.400530936166077 no 1322 0.374789276116531 430 18774327 YGL155W CDC43
SGTC_874 0599-0792 117 µM 0.319185749105011 0.400533825050283 no 1323 0.374792831399043 428 765305
SGTC_2674 ligustilide 100 µM 0.318427045542675 0.400767573192356 no 1324 0.375080512858196 405 5319022 A signalling regulator.
SGTC_310 1273-0058 1.06 µM 0.313317579612597 0.402342664407781 no 1325 0.377019697724398 384 2734232
SGTC_1094 duloxetine 25.4 µM 0.308323612327537 0.403883684872995 no 1326 0.378918050305694 370 60834 A selective serotonin reuptake inhibitor.
SGTC_592 k241-0073 46.5 µM 0.307672031751588 0.404084857881434 no 1327 0.37916595173089 419 4230158
SGTC_3225 9130819 49.47 µM 0.306418724433134 0.404471883003813 no 1328 0.379642926772743 414 4547121
SGTC_1804 st050076 49.1 µM 0.305719265005481 0.404687918882718 no 1329 0.379909201909801 406 3895976
SGTC_164 4100-3994 89.624 µM 0.304739276140538 0.40499064828314 no 1330 0.380282366725053 456 4615967
SGTC_3053 9095903 49.47 µM 0.299769126593671 0.406526854372455 no 1331 0.382176633163764 442 17174018
SGTC_2879 9041815 71.43 µM 0.298278567049683 0.40698784790933 no 1332 0.382745280595011 402 4942971
SGTC_1554 st069299 38.7 µM 0.298134647033779 0.407032365676584 no 1333 0.38280019938651 386 24207999
SGTC_1252 0493-0875 34.8 µM 0.297579420054083 0.407204121387215 no 1334 0.383012091882452 391 3960963
SGTC_1002 4049-0206 172 µM 0.296832060957384 0.407435340038941 no 1335 0.383297363453541 405 4662749
SGTC_723 4182-0001 115 µM 0.294645118926089 0.4081121231968 no 1336 0.384132495742708 424 744821 YLR208W SEC13
SGTC_1846 st056244 14.8 µM 0.290202716659832 0.409487735820399 no 1337 0.385830579004773 424 5393182
SGTC_1484 3473-2379 286 µM 0.290002587325874 0.409549733269898 no 1338 0.385907129111648 448 671917
SGTC_2401 5128683 200 µM 0.28903915401698 0.409848223933529 no 1339 0.386275707544299 421 708373
SGTC_219 mitoxanthrone 164.414 µM 0.288651426779602 0.409968364243579 no 1340 0.386424068434981 418 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_186 3455-3465 67.277 µM 0.288450061137045 0.410030762294639 no 1341 0.386501126025568 434 755278
SGTC_3091 9116372 49.47 µM 0.28811824966137 0.41013358713503 no 1342 0.386628111734082 390 17169793
SGTC_1956 st077085 54 µM 0.287795666798397 0.410233558050548 no 1343 0.386751577250847 449 24208685
SGTC_3045 9092950 49.47 µM 0.286649014127865 0.410588961733136 no 1344 0.387190540342472 409 44120432
SGTC_712 r015-0009 80.6 µM 0.285595696463704 0.410915501053342 no 1345 0.387593899980182 419 6813872 YLR060W FRS1
SGTC_3171 9103192 49.47 µM 0.285451048384425 0.410960348273881 no 1346 0.387649301300218 442 13018434
SGTC_3028 9087778 49.47 µM 0.284700446126701 0.411193086425212 no 1347 0.38793682441291 423 17217395
SGTC_2402 5553605 200 µM 0.284404111563127 0.411284979064093 no 1348 0.388050354236137 406 6758546
SGTC_2422 chlorphenesin carbamate 384.24 µM 0.283755204890615 0.411486220462904 no 1349 0.388298992660201 382 2724 A muscle relaxant with antifungal properties.
SGTC_1340 1486-1359 257 µM 0.281365363929212 0.412227567440832 no 1350 0.389215090517449 422 4309068
SGTC_1865 st057639 52.2 µM 0.281261524243949 0.412259786428235 no 1351 0.38925490939306 419 688818
SGTC_294 k038-0071 157 µM 0.280408324999304 0.412524536255319 no 1352 0.389582125363415 419 24152826
SGTC_2211 7117706 200 µM 0.279898760274322 0.412682674437801 no 1353 0.389777589190375 435 822771
SGTC_1314 1222-0010 41.1 µM 0.278364576344519 0.413158878150174 no 1354 0.390366254630597 407 3526027
SGTC_3090 9117696 49.47 µM 0.278000172700686 0.413272006191774 no 1355 0.390506113090404 443 7923821
SGTC_556 4058-0063 51.5 µM 0.277136233603446 0.413540242306455 no 1356 0.390837750310661 431 6615692
SGTC_2715 st079500 56.4 µM 0.276792380024634 0.413647013320396 no 1357 0.3909697662638 427 28246688
SGTC_1270 0831-1170 17.3 µM 0.276314785669801 0.413795323178335 no 1358 0.391153150253357 428 6764716
SGTC_3024 9090631 49.47 µM 0.274254868436979 0.414435140629165 no 1359 0.391944382485772 423 25236383
SGTC_2947 9072639 7.68 µM 0.273732948685277 0.414597286845699 no 1360 0.392144927547653 406 16488146
SGTC_1121 fusaric acid 630.51 nM 0.273491278370999 0.41467237214512 no 1361 0.39223779786936 397 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_2224 6650123 117.647 µM 0.27269037088759 0.414921230847333 no 1362 0.392545618603603 442 2908370
SGTC_2968 9090663 33.37 µM 0.272685895299062 0.414922621602301 no 1363 0.392547338940111 449 25236811
SGTC_683 panaxydol 45 µM 0.270439094178422 0.41562093216521 no 1364 0.393411233683951 414 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_1245 0418-0076 17.2 µM 0.268308121253742 0.416283489426523 no 1365 0.394231077740812 435 6790114
SGTC_1067 clotrimazole 1.36 µM 0.267451902664299 0.416549770085295 no 1366 0.394560620888082 404 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1356 1502-0781 85.8 µM 0.264872919229738 0.417352054863718 no 1367 0.395553680383879 407 567702
SGTC_1625 st003711 30.1 µM 0.264663614121457 0.41741718182857 no 1368 0.39563430494916 424 24207034 YER133W GLC7
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.264656703837046 0.417419332057689 no 1369 0.39563696687474 401 16623 A steroid.
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.264188423029767 0.417565049759845 no 1370 0.39581736567259 426 66535 A nucleotide analog.
SGTC_2431 5490079 200 µM 0.263571058085053 0.417757176150581 no 1371 0.396055231205171 438 5722345
SGTC_2144 5628481 200 µM 0.262926567270235 0.417957765162809 no 1372 0.39630358940361 437 2818399
SGTC_684 1140-0066 328 µM 0.262647978831505 0.41804447864073 no 1373 0.396410958076272 411 6813534
SGTC_3231 9132313 49.47 µM 0.262337912853849 0.418140994506648 no 1374 0.396530467508106 428 4905967
SGTC_1620 st003704 16.5 µM 0.262284879657291 0.41815750292222 no 1375 0.396550909187008 438 2834414
SGTC_777 1315-0167 517 µM 0.26075253187384 0.418634561294933 no 1376 0.397141676189086 413 4221767
SGTC_2761 levamisole 97.89 µM 0.260407224922563 0.418742080576146 no 1377 0.397274835236764 435 26879 An alkaline phosphatase inhibitor.
SGTC_104 0074-0074 590.992 µM 0.259692103765555 0.418964769331932 no 1378 0.397550642006719 416 3943124
SGTC_2979 9012552 45.46 µM 0.259587646370673 0.418997299543799 no 1379 0.397590933256477 442 17100905
SGTC_1221 2958-7315 257 µM 0.258925193237729 0.419203614152765 no 1380 0.397846479737975 413 4562705
SGTC_613 3914-0030 117 µM 0.258623774908522 0.419297495328523 no 1381 0.397962768734752 437 1145395
SGTC_1112 tnp00069 1.16933 µM 0.257657266726262 0.419598559490935 no 1382 0.398335714471324 435 145826
SGTC_2657 nystatin 74.44 µM 0.256170444363443 0.420061791672534 no 1383 0.398909614660872 416 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1621 st003705 32.4 µM 0.253656035632019 0.420845428872692 no 1384 0.399880650909247 420 24207032
SGTC_2221 6807166 181.081 µM 0.250457892441479 0.421842610771789 no 1385 0.401116632048701 428 674925
SGTC_1327 1436-0082 2.18 µM 0.250271649411182 0.421900696907561 no 1386 0.40118863971873 434 15992205
SGTC_2580 diallyl disulphide 81.36 µM 0.250204142246308 0.421921751700799 no 1387 0.401214741033904 414 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_1718 roemerine 11.9335 µM 0.248830101179479 0.422350349452923 no 1388 0.401746102946401 423 235224 An aporphine alkaloid with mutagenic activity.
SGTC_2330 7979373 200 µM 0.24852566804973 0.422445322217502 no 1389 0.401863856342527 403 1863007
SGTC_222 nsc-310342 10.666 µM 0.24840955739892 0.42248154597283 no 1390 0.40190876977938 456 432556
SGTC_2106 5357045 167.29 µM 0.247384965854843 0.422801222495663 no 1391 0.402305154088472 429 668842
SGTC_2829 7992743 58.44 µM 0.246050545943643 0.423217642869026 no 1392 0.40282155246985 435 16462845
SGTC_688 0527-0193 473 µM 0.241142586290435 0.424749960086251 no 1393 0.404722303686791 441 4007154
SGTC_2797 7859098 81.82 µM 0.24113665189993 0.424751813559462 no 1394 0.404724603324601 421 972681
SGTC_3135 9127742 49.47 µM 0.240507238914795 0.424948405966484 no 1395 0.404968526046583 432 3643468
SGTC_1430 4049-0248 69.1 µM 0.239001293303285 0.4254188524129 no 1396 0.405552289944589 446 22774488
SGTC_2988 9073640 71.4286 µM 0.237011991444309 0.426040458538452 no 1397 0.40632374372546 450 9102229
SGTC_497 capsazepine 133 µM 0.235872246052742 0.426396682848127 no 1398 0.406765902552024 412 2733484 A calcium channel blocker.
SGTC_1215 3852-0577 11.2 µM 0.235571966132406 0.426490544524472 no 1399 0.406882414533733 401 2884876
SGTC_405 ebelactone b 50 µM 0.235430959107303 0.426534622021279 no 1400 0.406937129687715 428 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_1565 sinapyl alcohol 95.1 µM 0.235196665192599 0.426607862168862 no 1401 0.407028047100486 463 5280507 A phenol propionate derived from cinnamic acid.
SGTC_615 k087-0205 167 µM 0.234563296373217 0.426805865570819 no 1402 0.407273850014881 454 9642773
SGTC_1445 4239-0156 97.7 µM 0.234135352159454 0.426939659693706 no 1403 0.407439950759922 457 4008346
SGTC_2388 9080168 200 µM 0.232840895181459 0.427344414801658 no 1404 0.407942477882129 458 15943073
SGTC_2513 baicalein 25.65 µM 0.232526624932444 0.427442693422845 no 1405 0.408064505070842 439 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_3003 9075612 71.4286 µM 0.230052108327684 0.428216681312479 no 1406 0.409025639404485 451 6501993
SGTC_931 2812-0076 566 µM 0.228486105061972 0.428706644162526 no 1407 0.409634178506642 445 3450959
SGTC_652 0437-0092 114 µM 0.228384746767694 0.428738360406249 no 1408 0.409673573226832 425 3091274
SGTC_2253 7938677 135.83 µM 0.227796751574941 0.428922360329451 no 1409 0.4099021260896 432 2301972
SGTC_894 0960-0238 55.9 µM 0.227530534988223 0.429005671929111 no 1410 0.41000561415646 458 6741907 YDL195W SEC31
SGTC_3175 9106517 49.47 µM 0.22627989126543 0.429397099015043 no 1411 0.410491868629081 446 41468073
SGTC_647 0140-0236 81 µM 0.225512341106749 0.429637361644854 no 1412 0.410790362902016 443 990837
SGTC_3172 9105863 49.47 µM 0.22538644801436 0.429676771860083 no 1413 0.410839326681233 461 2348785
SGTC_1473 k844-0725 134 µM 0.224938240506235 0.429817086708796 no 1414 0.411013659937122 439 54682906
SGTC_853 0419-0306 21 µM 0.222159513860191 0.43068718589343 no 1415 0.412094854917408 444 762713
SGTC_3097 9117246 49.47 µM 0.21911495196997 0.431640912034044 no 1416 0.41328025189123 441 16423892
SGTC_2156 5649887 115 µM 0.216970533178017 0.432312902883016 no 1417 0.414115654521596 448 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_2250 alverine citrate 130 µM 0.214890361912806 0.432964947820512 no 1418 0.414926399721142 452 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_175 3793-3120 23.7 µM 0.214395024827287 0.433120241839424 no 1419 0.415119510542065 468 5322297
SGTC_54 0159-0055 9 µM 0.213283931591419 0.433468620205753 no 1420 0.415552752975283 454 3319099
SGTC_1666 st014829 29 µM 0.209972157540051 0.434507317972893 no 1421 0.416844701843167 443 3858230
SGTC_725 1497-0963 19 µM 0.209480368086787 0.434661600509314 no 1422 0.417036629706358 470 3549977
SGTC_697 0508-1955 564 µM 0.207203849763371 0.435375911472473 no 1423 0.417925330440419 452 6243113
SGTC_1892 st058411 7.36 µM 0.206818381019882 0.435496882266598 no 1424 0.418075850260317 470 3934738
SGTC_1388 3346-4487 254 µM 0.203759390113166 0.43645709165926 no 1425 0.419270764506865 457 3345614
SGTC_3123 9126162 49.47 µM 0.200087704999549 0.437610118342013 no 1426 0.420705994462437 445 25239884
SGTC_2110 5483698 200 µM 0.19916688056815 0.437899370206474 no 1427 0.42106610293355 432 2848765 YHR062C RPP1
SGTC_485 niflumic acid 177 µM 0.199027899010219 0.437943030355981 no 1428 0.421120460446039 453 4488 A COX2 inhibitor.
SGTC_3060 1327-0027 12.5 µM 0.197953389180407 0.438280606066054 no 1429 0.421540766025552 465 16000455 YPR107C YTH1
SGTC_153 4077-0274 519.67 µM 0.191523453071817 0.440301611040693 no 1430 0.424057753865237 476 3121976
SGTC_2012 4023501 200 µM 0.191469467425899 0.440318586029338 no 1431 0.424078899726777 462 3477460
SGTC_2165 5727197 32.143 µM 0.190719946077043 0.440554273261857 no 1432 0.424372505409546 460 1361712
SGTC_78 0336-0123 156.75 µM 0.188528183350403 0.441243594305155 no 1433 0.425231312247281 432 6765896
SGTC_3094 9117742 49.47 µM 0.187987613937419 0.441413633712679 no 1434 0.425443180363828 481 17149698
SGTC_1962 st076595 64.5 µM 0.187535799985315 0.441555762834751 no 1435 0.425620278622804 447 279619
SGTC_3337 9144342 33.5465 µM 0.186891286174849 0.44175852342827 no 1436 0.425872935725738 458 17682949
SGTC_2251 lansoprazole 556 µM 0.186183035227664 0.441981352982809 no 1437 0.426150613641751 473 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_465 cgp-37157 41 µM 0.184488632207878 0.442514519579446 no 1438 0.426815072141405 462 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_1201 1889-3372 45.9 µM 0.182568791073618 0.443118749086414 no 1439 0.427568186919114 453 5392199
SGTC_2128 5255449 168.493 µM 0.182186108860409 0.443239206100803 no 1440 0.427718337041273 431 736008
SGTC_2616 abietic acid 100 µM 0.181560117091654 0.443436261053232 no 1441 0.427963975250317 487 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_343 4130-2827 29.8 µM 0.180268820888419 0.443842790266078 no 1442 0.428470765991258 429 1118244
SGTC_2953 9074162 66.49 µM 0.179693937174101 0.444023795683339 no 1443 0.428696426701578 492 16451992
SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.179535359130605 0.44407372694139 no 1444 0.428758677889297 456 5377381
SGTC_57 miconazole 162.5 nM 0.178266732630581 0.444473209575594 no 1445 0.429256751912996 472 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1191 1487-1166 10.6 µM 0.176657733179857 0.444979954641741 no 1446 0.429888621324787 483 3955771
SGTC_2047 4141938 200 µM 0.174291542218759 0.445725335925991 no 1447 0.430818172923785 481 3807862
SGTC_3306 9127676 59.7925 µM 0.173659052125763 0.445924611235053 no 1448 0.431066710067448 434 41905287
SGTC_1811 st050069 61.5 µM 0.17253869406901 0.446277630022064 no 1449 0.431507021999781 493 3877702
SGTC_458 nppb 133 µM 0.171950546681018 0.446462969158513 no 1450 0.431738203917811 446 4549 A chloride channel blocker.
SGTC_386 1509-0011 3.07 µM 0.169117213933633 0.447355982417755 no 1451 0.432852222595719 472 3107280
SGTC_2065 5221596 34.26 µM 0.168086261030924 0.44768098588333 no 1452 0.433257708841016 448 788581
SGTC_2008 4012253 172 µM 0.168050276753983 0.447692330407493 no 1453 0.433271863163971 466 603940
SGTC_995 3931-2021 34.6 µM 0.167487273538326 0.447869830260627 no 1454 0.433493330168087 468 730143
SGTC_1961 st076550 68.7 µM 0.16735652238271 0.447911054097278 no 1455 0.433544766376146 446 1579337
SGTC_814 3342-0569 96 µM 0.166284720566524 0.448248997960785 no 1456 0.433966444933758 481 4346283
SGTC_236 1509-0011 5.31 µM 0.165925632724 0.4483622283613 no 1457 0.434107737551348 480 3107280
SGTC_316 k060-0003 58.6 µM 0.165560346643601 0.448477417555329 no 1458 0.434251477667567 465 6152314
SGTC_512 prima-1 270 µM 0.164831781181329 0.448707176114098 no 1459 0.434538194205821 447 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_1387 3342-1166 1.8 µM 0.164447258706323 0.448828445088659 no 1460 0.434689531429296 456 3418228
SGTC_2 0422-0095 29 µM 0.162642203339652 0.449397779073232 no 1461 0.435400077962858 431 6790840
SGTC_2350 9023895 38.85 µM 0.161382963025719 0.449795018854668 no 1462 0.435895892161269 482 2997209
SGTC_1487 3970-0795 2.82 µM 0.160880139445095 0.449953653593138 no 1463 0.436093902479648 452 3765103
SGTC_1193 1488-0126 41.5 µM 0.159715468269981 0.450321123890023 no 1464 0.436552607704364 453 1384710
SGTC_2237 6667747 47.222 µM 0.159382298708174 0.45042625146748 no 1465 0.436683842111833 495 729940 YDL015C TSC13
SGTC_2435 5706476 10.6 µM 0.159215151289955 0.45047899410024 no 1466 0.436749683562584 473 5725375
SGTC_162 k030-0015 37.8 µM 0.158610641730588 0.450669751727537 no 1467 0.436987822025442 467 1809920 YMR134W ERG29
SGTC_2491 paeonol 100 µM 0.158258100733183 0.45078100400627 no 1468 0.437126711387107 465 11092 Increases levels of cortical cytochrome oxidase.
SGTC_1008 4106-0037 6 µM 0.157612483419734 0.45098475315883 no 1469 0.437381083092877 503 2905394
SGTC_1410 3909-8106 77.9 µM 0.155334172027271 0.45170386401404 no 1470 0.438278938586294 485 1039210
SGTC_9 0092-0002 10.449 µM 0.155199385709928 0.451746412047941 no 1471 0.438332066276742 471 759368
SGTC_2859 9028643 45.46 µM 0.15497119538674 0.451818446213351 no 1472 0.438422012841813 466 17151580
SGTC_1557 sumaresinolic acid 42.3 µM 0.154549037984259 0.451951715274149 no 1473 0.438588424460342 443 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_147 4466-0538 29.23 µM 0.153226533826339 0.452369245923935 no 1474 0.439109816887861 439 6742687 YHR072W ERG7
SGTC_99 0109-0120 622.8 µM 0.153137620224338 0.452397318924671 no 1475 0.439144874551079 494 759414
SGTC_19 0279-0214 38.434 µM 0.151945473511806 0.452773742482259 no 1476 0.439614970992529 477 3566274 YBR002C RER2
SGTC_1564 D-Arginine 115 µM 0.150665929979874 0.453177809041651 no 1477 0.440119625156109 471 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_246 cycloheximide 667 µM 0.150198311175217 0.453325490322918 no 1478 0.440304079134084 475 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_1702 st027038 51 µM 0.1497072455745 0.453480583414998 no 1479 0.440497795733705 454 5521182
SGTC_1161 k007-0610 110 µM 0.148329496351532 0.453915755316565 no 1480 0.441041369053666 487 5843850
SGTC_1806 st050005 60.3 µM 0.148140224279104 0.453975542582831 no 1481 0.441116052629156 472 5194765
SGTC_1091 telmisartan 47.6 µM 0.147938232291457 0.454039348966595 no 1482 0.441195757579021 474 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_2621 lithochol-11-enic acid 100 µM 0.147936333105333 0.454039948897996 no 1483 0.441196506998939 484 6708711
SGTC_3149 9097855 49.47 µM 0.147579885559122 0.454152548498778 no 1484 0.441337165127453 520 25236625 YMR079W SEC14
SGTC_1235 benzylparaben 21.5 µM 0.146559832902616 0.454474797227401 no 1485 0.441739729969285 490 7180
SGTC_3030 9087619 49.47 µM 0.146452454061665 0.454508721433906 no 1486 0.441782110649043 503 25236973
SGTC_3017 9080681 49.47 µM 0.146211962282077 0.454584701226077 no 1487 0.441877031254991 484 16451914
SGTC_2712 st079126 47.7 µM 0.145896038214549 0.454684515249801 no 1488 0.442001729586095 473 3152970
SGTC_2769 toremifene 3.73 µM 0.145246896227111 0.454889616143344 no 1489 0.44225797032659 479 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_251 melphalan 456.522 µM 0.142507578632818 0.455755254267781 no 1490 0.443339546792072 488 460612 A DNA alkylator.
SGTC_808 0711-0032 135 µM 0.142240268501673 0.455839736928679 no 1491 0.443445112736258 500 4252555
SGTC_2833 9001315 45.46 µM 0.14011415448751 0.456511760433432 no 1492 0.444284898625536 461 2989378
SGTC_1093 fluphenazine 7.97 µM 0.138252512295431 0.457100291735981 no 1493 0.445020427355572 503 6602611 An atypical antipsychotic.
SGTC_773 4358-1457 44.6 µM 0.137721550601704 0.457268164912963 no 1494 0.445230243390705 488 1186886
SGTC_2304 7443016 91.4 µM 0.135071669889847 0.458106086195091 no 1495 0.446277604515862 505 939854
SGTC_145 3737-0113 38.366 µM 0.134688333093331 0.458227316991181 no 1496 0.446429148986952 472 6849351
SGTC_3309 9129340 25.759 µM 0.134477418779017 0.458294020594944 no 1497 0.44651253304557 477 17158987
SGTC_2987 9018338 71.43 µM 0.134237934209393 0.458369761230186 no 1498 0.446607215097734 491 5055682
SGTC_1199 1638-0010 4.46 µM 0.133067413140594 0.458739978007615 no 1499 0.447070033232173 471 3111136
SGTC_728 3030-5151 22.5 µM 0.132555926762694 0.458901764086083 no 1500 0.447272295040617 473 3125388
SGTC_3133 9127736 49.47 µM 0.131584146117697 0.459209162615652 no 1501 0.447656613021827 479 27243420
SGTC_1284 0929-0043 16 µM 0.129986502306648 0.459714590248127 no 1502 0.448288552840828 484 1239883
SGTC_369 0957-0393 4.5 µM 0.128903008793155 0.460057399348363 no 1503 0.448717197930902 474 6997992
SGTC_2420 aureobasidin a 50 nM 0.128734433269827 0.460110738036551 no 1504 0.448783894145138 442 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_1365 1672-3266 55.4 µM 0.128500736830435 0.460184682707705 no 1505 0.448876357576394 493 6415873
SGTC_1610 st001799 48.1 µM 0.127275492229074 0.460572388922399 no 1506 0.449361178453894 487 621897
SGTC_1003 4049-0218 100 µM 0.125930403846229 0.460998060657899 no 1507 0.44989350773186 501 295161
SGTC_2288 7946289 167.31 µM 0.125535233858688 0.461123126155947 no 1508 0.450049916534604 486 1246052
SGTC_1757 st041620 31.8375 µM 0.123886329580408 0.461645021502348 no 1509 0.450702638486985 478 5289815
SGTC_1385 3091-4834 14.1 µM 0.123254887747743 0.461844896946879 no 1510 0.450952631365252 473 4072814
SGTC_1914 st062367 72.6 µM 0.119841802914556 0.462925434130529 no 1511 0.452304233309012 479 978205
SGTC_3346 9158254 43.5805 µM 0.119032860685531 0.46318157486923 no 1512 0.452624660893681 502 17639500
SGTC_2005 4024620 188 µM 0.118686380981 0.463291287709622 no 1513 0.452761913339618 513 236743
SGTC_1539 benzyladenosine 56 µM 0.118281831195134 0.46341939198098 no 1514 0.452922176469681 462 92208 A nucleotide analog.
SGTC_1709 st033179 39.1045 µM 0.117967835834342 0.463518824007256 no 1515 0.453046571587766 491 573381
SGTC_2497 7-hydroxyflavone 100 µM 0.117883455417987 0.463545544904738 no 1516 0.453080001249393 493 5281894
SGTC_3245 9134821 49.47 µM 0.115112833080759 0.464423013487242 no 1517 0.454177844098232 481 17014901
SGTC_2403 6032726 181.2 µM 0.114300158739403 0.464680424130156 no 1518 0.454499928334517 494 2881040
SGTC_872 0588-0139 234 µM 0.113975284575774 0.464783330582455 no 1519 0.454628692901044 462 2047100
SGTC_1676 st018489 23.4 µM 0.113561351816354 0.464914450458711 no 1520 0.454792762937531 511 3696235
SGTC_2327 6189656 200 µM 0.113457080947586 0.464947480539055 no 1521 0.454834093875211 504 5349088
SGTC_73 0327-0325 16.231 µM 0.112836864792127 0.465143952567049 no 1522 0.455079945545398 497 53298
SGTC_2512 diallyl trisulfide 49.23 µM 0.112802586020429 0.465154811642062 no 1523 0.455093534041816 515 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_2563 tomatine 8.54 µM 0.111906795026716 0.46543859590982 no 1524 0.455448654398653 510 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_792 4534-1957 155 µM 0.110354404138259 0.465930430866319 no 1525 0.456064156212575 476 1717904
SGTC_2647 atorvastatin 60.16 µM 0.108987847058752 0.466363432274513 no 1526 0.45660606477712 499 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_2592 piperlongumine 83.33 µM 0.108781179630975 0.466428919506982 no 1527 0.45668802585041 489 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_3248 9135562 49.47 µM 0.108699922508828 0.466454667906582 no 1528 0.456720251660509 464 17650701
SGTC_2137 5261020 140 µM 0.106455274874895 0.467165997111104 no 1529 0.457610569588452 485 763655
SGTC_2709 st078560 56 µM 0.102560661440203 0.468400448278924 no 1530 0.45915583288119 501 17250903
SGTC_2550 chrysin dimethyl ether 71.87 µM 0.101007961183615 0.468892683323316 no 1531 0.459772070195352 490 88881 An O-methylated flavonoid and antioxidant.
SGTC_413 propylparaben 100 µM 0.100811008558372 0.468955124406229 no 1532 0.459850243899112 483 7175 A pharmaceutical preservative.
SGTC_2841 9004761 38.96 µM 0.100596196590674 0.469023228415146 no 1533 0.459935508036232 490 2991039
SGTC_819 1013-0258 27.7 µM 0.0987352038408048 0.469613275481053 no 1534 0.460674258398304 489 5753198
SGTC_892 0929-0076 29 µM 0.0980229320648604 0.469839126369872 no 1535 0.460957041950484 504 5751038
SGTC_2262 9014885 67.46 µM 0.0979166378058407 0.469872831547638 no 1536 0.460999244207504 515 6457424
SGTC_656 4090-1979 187 µM 0.0964933632477409 0.470324162812719 no 1537 0.461564372346294 504 22330961
SGTC_883 0850-0245 24.6 µM 0.0955655943728966 0.470618385992207 no 1538 0.461932795902899 505 6823229 YPR165W RHO1
SGTC_639 0833-0042 114 µM 0.0944604919496787 0.47096886784719 no 1539 0.462371682464356 512 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_897 1000-0139 31.4 µM 0.0929010088143032 0.471463494172404 no 1540 0.462991102148695 507 6151020
SGTC_736 0958-0254 92.6 µM 0.0924787617475929 0.471597427249344 no 1541 0.463158832285757 519 6812352
SGTC_604 1000-0114 314 µM 0.0911716465970422 0.472012053039762 no 1542 0.463678101920051 501 1572745
SGTC_2430 5571206 200 µM 0.0901337357025132 0.472341307042281 no 1543 0.464090470550615 516 1731771
SGTC_2125 5246583 200 µM 0.0885124961530819 0.472855646742352 no 1544 0.464734676413731 504 835267
SGTC_1254 0550-0035 264 µM 0.0865917203356714 0.47346507310286 no 1545 0.465498023697502 508 15121435
SGTC_296 1222-0039 74.9 µM 0.0862402159112554 0.473576605669257 no 1546 0.465637731050674 497 5984176
SGTC_2517 totarol 10 µM 0.0856195384504128 0.473773552055368 no 1547 0.465884433028158 490 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_1836 st055642 81 µM 0.0853515589583223 0.47385858627581 no 1548 0.465990951459012 519 8571
SGTC_3352 9151559 45.5865 µM 0.0850022029680328 0.473969444361254 no 1549 0.466129819667506 495 17159339
SGTC_590 k048-0076 22.4 µM 0.0846563378462458 0.474079196705563 no 1550 0.466267304326086 498 6832814
SGTC_1147 3809-1045 12.3 µM 0.0842648639338506 0.474203424324136 no 1551 0.466422923766465 489 325925
SGTC_152 4469-0003 551.229 µM 0.0839312136785247 0.474309304564553 no 1552 0.466555561091851 493 697280
SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.0833273160255096 0.474500949455091 no 1553 0.466795640385664 516 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_2371 9071574 200 µM 0.0831236133646437 0.474565595142954 no 1554 0.466876625034155 513 45596039
SGTC_2935 9038016 29.96 µM 0.0825026087736066 0.47476267705229 no 1555 0.467123521953772 517 6463195
SGTC_1108 betulinic acid 729.144 nM 0.0821590455545273 0.474871712872451 no 1556 0.467260120105703 487 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_2223 6903751 107.57 µM 0.0821583402896955 0.474871936702568 no 1557 0.467260400517667 520 5598863
SGTC_954 1189-0853 2.85 µM 0.0813865365258272 0.475116889038434 no 1558 0.467567277943088 511 2828194
SGTC_3204 9114183 49.47 µM 0.0809278218266089 0.475262478741833 no 1559 0.46774967695504 497 17027248
SGTC_1963 st076565 50.3 µM 0.0803336416594272 0.475451068219315 no 1560 0.467985951245974 497 4914280
SGTC_2040 5100729 123 µM 0.0784568256475719 0.476046795097858 no 1561 0.468732336227948 520 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_2552 juarezic acid 87.02 µM 0.0782836667744223 0.476101760792953 no 1562 0.468801204806709 483 1549512
SGTC_2972 9093619 59.92 µM 0.077397254782487 0.476383141006349 no 1563 0.469153762299933 451 25236256
SGTC_2493 resveratrol 26.09 µM 0.0760422488875409 0.476813293107685 no 1564 0.469692742865826 514 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_1854 st056233 32.9 µM 0.075100831624452 0.477112165762245 no 1565 0.470067243077324 507 5393174
SGTC_2203 7227154 166.4 µM 0.0749621623889841 0.477156190311252 no 1566 0.470122408596178 499 896304
SGTC_1197 1601-0112 267 µM 0.07492186379081 0.477168984316049 no 1567 0.470138440328009 526 7350313
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.0741826047739482 0.477403688537952 no 1568 0.470432543544522 507 279621
SGTC_2866 9034245 58.44 µM 0.0741534409403134 0.477412947801512 no 1569 0.470444146274188 513 6462273
SGTC_2075 5212009 200 µM 0.0740950736073203 0.477431478958772 no 1570 0.47046736758974 527 780898
SGTC_407 eburnamonine 100 µM 0.0730450688670217 0.477764855288011 no 1571 0.470885126752623 517 3195
SGTC_1241 0364-0022 50.8 µM 0.0725536405724408 0.477920889048867 no 1572 0.471080659451226 511 4563895
SGTC_2787 5284540 71.43 µM 0.0719691764502349 0.478106467088402 no 1573 0.471313218925132 515 736958
SGTC_631 k072-0230 41.5 µM 0.0717775079388059 0.478167326379018 no 1574 0.47138948635315 502 5773147
SGTC_315 k915-0449 187 µM 0.0709116325482604 0.478442268641653 no 1575 0.471734042624514 511 20970215 YNL149C PGA2
SGTC_1291 0993-0025 5.79 µM 0.069101056637768 0.479017215590248 no 1576 0.47245458998276 511 4353356
SGTC_2985 9022375 71.43 µM 0.0690861118940648 0.479021961465131 no 1577 0.472460537858584 493 4939335
SGTC_1285 0929-0069 65.5 µM 0.0687695045004176 0.479122504474568 no 1578 0.472586546242243 496 1206237
SGTC_3338 9144300 39.5675 µM 0.068729018653527 0.479135361405081 no 1579 0.472602659633636 506 4901274
SGTC_537 1334-0398 209 µM 0.0686626564159835 0.479156435845735 no 1580 0.472629071941027 494 5846986
SGTC_1938 st074717 56.4 µM 0.0683745709785058 0.479247922879039 no 1581 0.472743731932968 528 17250979
SGTC_3137 9097352 49.47 µM 0.0670130965592255 0.479680299798088 no 1582 0.47328563854586 519 44120435
SGTC_364 0083-0097 67.7 µM 0.0657431646330919 0.480083626224445 no 1583 0.47379115316001 508 5207356
SGTC_342 k048-0088 23.3 µM 0.0634941924324067 0.480797942566267 no 1584 0.474686491841048 524 6820570
SGTC_2608 thymoquinone 42.66 µM 0.0634094541940291 0.480824858262129 no 1585 0.474720229522476 520 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_1286 0929-0070 131 µM 0.0633876109739269 0.480831796412855 no 1586 0.474728926211319 506 1420408
SGTC_2814 7977482 42.97 µM 0.0579419957242802 0.482561685054512 no 1587 0.47689741577167 524 6456762
SGTC_1224 0823-0416 294 µM 0.0576488846664686 0.482654806174031 no 1588 0.477014155029334 508 3598164
SGTC_2314 7727897 200 µM 0.0564108389523758 0.48304814256332 no 1589 0.477507261235364 527 900724
SGTC_920 mycophenolic acid 780.421 nM 0.0554617828070775 0.48334967599569 no 1590 0.47788528798275 519 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_2584 androsterone 48.74 µM 0.0554102189075662 0.483366059114888 no 1591 0.477905827417761 516 2754130 A steroid.
SGTC_554 4483-2211 187 µM 0.055054411136764 0.483479108759558 no 1592 0.478047557833513 511 747107
SGTC_2058 5236698 133 µM 0.0520608971362481 0.484430279922423 no 1593 0.479240085127636 504 766665
SGTC_477 mead ethanolamide 10 µM 0.0510306755183428 0.48475764744497 no 1594 0.479650538428056 520 16061185
SGTC_3318 9139014 38.6185 µM 0.0509914627242288 0.484770108070509 no 1595 0.479666161729406 529 16643984
SGTC_3286 9117135 37.221 µM 0.0508653515468047 0.484810182442792 no 1596 0.479716407606376 532 3438150
SGTC_2961 9083290 32.55 µM 0.049625535555574 0.485204167105682 no 1597 0.480210398633857 532 17741490
SGTC_868 0527-0199 213 µM 0.0490871932250532 0.485375244287484 no 1598 0.480424904715215 525 2849450
SGTC_1102 cgs 12066b 26.1 µM 0.0480797617428265 0.485695398228915 no 1599 0.480826337669459 525 6438352 A 5-HT1B full agonist.
SGTC_2518 prenyletin 46.28 µM 0.0476440773961503 0.485833858216265 no 1600 0.480999951606738 532 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_3273 9137859 49.47 µM 0.0459433171228397 0.4863743740785 no 1601 0.481677714269104 529 2377234
SGTC_2946 9065502 71.43 µM 0.0457408976862031 0.486438706357515 no 1602 0.481758383133307 518 16489101
SGTC_2233 sulbentine 40.3845 µM 0.0455057839481432 0.486513429874698 no 1603 0.481852082376162 519 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_1447 4239-0816 81.9 µM 0.0453686710713675 0.486557007114893 no 1604 0.481906726063644 507 1341554
SGTC_345 1362-0200 395 µM 0.0445203525415482 0.486826623417869 no 1605 0.482244814538903 506 1419823
SGTC_3128 9127691 49.47 µM 0.044277697378747 0.486903746255216 no 1606 0.482341524574712 531 41316314
SGTC_1355 1499-0035 1.68 µM 0.0437943837954791 0.48705735876384 no 1607 0.482534151936446 524 1548538
SGTC_2932 9016711 44.54 µM 0.0434724852943329 0.48715966946561 no 1608 0.482662448669275 521 7117328
SGTC_2862 9027634 71.43 µM 0.0430178205399587 0.487304179405503 no 1609 0.482843664132957 530 5012562
SGTC_1716 st033144 30.6155 µM 0.0425584498257313 0.487450186773271 no 1610 0.483026758847748 531 674617
SGTC_1183 1254-0324 198 µM 0.0410373071000791 0.48793368192204 no 1611 0.483633077067779 525 5799357
SGTC_1373 2887-0003 58.5 µM 0.0399245431518197 0.488287385166443 no 1612 0.484076642046907 533 776948
SGTC_198 3454-2873 16.191 µM 0.0394762941857043 0.488429868239976 no 1613 0.484255326640172 533 710957
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 0.0390599486581556 0.488562211620581 no 1614 0.48442129646231 523 16725076
SGTC_2423 st077119 87.2 µM 0.0386096395744895 0.488705352383668 no 1615 0.484600808377807 528 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_3196 9111891 49.47 µM 0.0378869397210105 0.488935081647806 no 1616 0.484888913083294 532 18891510
SGTC_378 3970-0959 8.33 µM 0.0377421565781421 0.488981105243174 no 1617 0.48494663191843 532 6615653
SGTC_1437 4092-1038 11.6 µM 0.0376485560225233 0.48901085902061 no 1618 0.48498394661713 533 3977136
SGTC_1729 st035615 45.989 µM 0.0349765989328988 0.489860246827482 no 1619 0.486049200399785 541 17385451
SGTC_2160 5660466 132.927 µM 0.0338045489831664 0.490232844246108 no 1620 0.486516504228195 533 2859134
SGTC_2753 fluvastatin 17.09 µM 0.0331396707999536 0.490444214384498 no 1621 0.486781603693958 522 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_2920 7982904 15.77 µM 0.0326802587438016 0.490590266754788 no 1622 0.486964783360994 527 6456808
SGTC_1205 4161-2785 76 µM 0.0325690686106766 0.490625615565811 no 1623 0.487009118205649 510 3498106
SGTC_3283 9109332 35.8195 µM 0.032211223134096 0.490739379864735 no 1624 0.487151803028851 533 17027281
SGTC_885 0865-0106 16.8 µM 0.0315449635421404 0.490951195511487 no 1625 0.487417467124962 532 2793380
SGTC_2039 Aminomethylbenzodioxan 200 µM 0.0310116059311528 0.49112076112203 no 1626 0.487630141965386 528 15053
SGTC_1242 0402-0103 60.1 µM 0.0299296623065516 0.491464738669698 no 1627 0.488061574670814 525 432868
SGTC_392 N-ethylmaleimide 8.33 µM 0.0296413696336915 0.491556395364684 no 1628 0.488176535800005 528 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_2856 9022925 19.48 µM 0.029431877437467 0.491622999357265 no 1629 0.48826007464624 532 4944862
SGTC_2780 5215298 71.43 µM 0.0292032005316896 0.491695703023807 no 1630 0.488351264334292 531 2834131
SGTC_1842 st055362 61.2 µM 0.0290361721691214 0.491748806830831 no 1631 0.488417870764417 532 676032
SGTC_2809 7964133 12.99 µM 0.0289384054160113 0.491779890163351 no 1632 0.488456857672766 524 1253665
SGTC_581 0958-0271 211 µM 0.0283442551815156 0.491968791533113 no 1633 0.488693792117082 528 4591145
SGTC_3185 9108267 49.47 µM 0.0282162183364682 0.492009499211109 no 1634 0.488744851006173 524 4910486
SGTC_66 0109-0187 42.4 µM 0.028070900826109 0.492055701156518 no 1635 0.488802801350469 499 759417
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.028063032522567 0.492058202791542 no 1636 0.48880593911329 516 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_2460 5552655 174.22 µM 0.0271553518637563 0.492346791305198 no 1637 0.489167913305896 523 5401989
SGTC_290 2043-6722 48.1 µM 0.0271542096159256 0.492347154474689 no 1638 0.489168368828872 530 773758 YLR208W SEC13
SGTC_18 0111-0177 500 nM 0.0265581007122302 0.492536683876252 no 1639 0.48940609612453 536 721752
SGTC_1752 st044819 83.042 µM 0.0264060418660369 0.492585030384304 no 1640 0.489466737559677 529 441209 YML126C ERG13
SGTC_1491 4138-0063 26.5 µM 0.0259450791048494 0.492731592331641 no 1641 0.489650572104354 535 23883227
SGTC_1255 0566-0045 221 µM 0.0256334609174163 0.492830671105482 no 1642 0.489774848440035 535 2788469
SGTC_1416 3966-0321 25.3 µM 0.0246875045136847 0.493131439933154 no 1643 0.490152110998927 536 582530 YLR208W SEC13
SGTC_3218 9131285 49.47 µM 0.0245575946034094 0.493172745371085 no 1644 0.490203921846682 533 17156417
SGTC_420 mitomycin C 81.9 mM 0.0243195259231432 0.493248440564127 no 1645 0.490298869151104 532 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_3086 9117350 49.47 µM 0.0232898862098733 0.493575822708463 no 1646 0.490709519581275 538 2679265
SGTC_729 4092-0585 94.1 µM 0.0229939321475525 0.493669924469126 no 1647 0.490827556557897 536 2169061
SGTC_2790 5423970 71.43 µM 0.0210473573422092 0.494288867291092 no 1648 0.491603939166967 533 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_3029 9088683 49.47 µM 0.0181353324695643 0.495214814734018 no 1649 0.492765445673365 546 25236615
SGTC_806 3966-4455 5.86 µM 0.0177719749980541 0.495330354779892 no 1650 0.492910380970207 515 714982
SGTC_2185 6113692 200 µM 0.0177579254415261 0.495334822251773 no 1651 0.492915985047952 533 874150
SGTC_399 oxolinic acid 75 µM 0.0176508326019199 0.495368875605567 no 1652 0.492958702214312 524 4628 A DNA gyrase inhibitor.
SGTC_1122 capsaicin 818.572 nM 0.0174958001109476 0.495418172857184 no 1653 0.493020541680321 545 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_1669 st015249 58.4 µM 0.0172070198639551 0.495509999423605 no 1654 0.493135730988781 538 722793
SGTC_192 3455-0609 60.9 µM 0.0167883487764358 0.495643129201201 no 1655 0.493302732459073 537 3769639
SGTC_1837 st055472 66.5 µM 0.0131559785968409 0.49679817551063 no 1656 0.494751675294575 535 676091
SGTC_3217 9129673 49.47 µM 0.0127455392092894 0.496928691746889 no 1657 0.494915403187689 537 17248312
SGTC_535 2293-4129 48.2 µM 0.0126597664831055 0.496955966786689 no 1658 0.494949618794077 545 396118 YIL048W NEO1
SGTC_2587 piperic acid 92.2 µM 0.0123917995911506 0.497041178202729 no 1659 0.495056513730723 546 5370536
SGTC_1647 st011722 22.4 µM 0.0110587507432839 0.497465079439987 no 1660 0.495588286682725 538 2854783
SGTC_25 0118-0223 35.662 µM 0.0109197565563524 0.497509278899386 no 1661 0.495643733992465 541 5333628
SGTC_3138 9097216 49.47 µM 0.0106899803944689 0.49758234664161 no 1662 0.495735396067558 543 25237486
SGTC_1458 k015-0034 6.33 µM 0.00950617493268054 0.497958792459965 no 1663 0.496207642012112 543 3598957
SGTC_757 1066-0008 322 µM 0.00902764969565751 0.498110962274421 no 1664 0.496398537762753 529 6842497
SGTC_1432 4049-0298 68.4 µM 0.00871777167529107 0.498209502848749 no 1665 0.496522156340318 544 741646
SGTC_510 ag-490 170 µM 0.00856069599305315 0.498259452635339 no 1666 0.496584818132653 540 5328779
SGTC_1204 4049-0315 18.3 µM 0.00817809911166184 0.498381117873336 no 1667 0.496737446858387 539 588402
SGTC_2945 9067681 61.76 µM 0.00795504241803147 0.498452049639636 no 1668 0.496826430709101 543 16456930
SGTC_2931 9014674 55.67 µM 0.00794161234726054 0.498456320387934 no 1669 0.49683178836292 540 2996810
SGTC_421 streptovitacin 30 mM 0.00707922878435442 0.498730557797474 no 1670 0.497175819914496 540 91467 include heat shock
SGTC_1498 4478-3555 97.6 µM 0.00690642730054641 0.498785508632715 no 1671 0.497244756046921 544 3437919
SGTC_269 exalamide 29 µM 0.00660378440002047 0.498881749065852 no 1672 0.497365490340671 545 3316 A derivative of salicylamide.
SGTC_2383 9036125 200 µM 0.00633993668086852 0.498965652685791 no 1673 0.497470748146739 545 79580
SGTC_3275 9138069 49.47 µM 0.00507123806244453 0.49936909963715 no 1674 0.497976877394508 546 17617007
SGTC_2364 9055074 200 µM 0.00485843319526251 0.499436771791942 no 1675 0.498061773207012 544 6470630
SGTC_1979 st071809 45.3 µM 0.00334215158457108 0.499918951173308 no 1676 0.498666676907603 546 4976333
SGTC_3324 9138759 60.749 µM 0.00318560096407185 0.499968734478216 no 1677 0.498729131236419 545 45595710
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.00308965244867433 0.499999246233633 no 1678 0.498767408967521 545 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1977 st070720 65.3 µM 0.00308491179951553 0.499999246233633 no 1679 0.498769300203894 545 682188
SGTC_366 0181-0206 4.31 µM 0.00149258416608996 0.499492884065966 no 1680 0.499404545290182 544 274874
SGTC_949 1165-0505 146 µM 0.00117437733411323 0.499391693969531 no 1681 0.499531491335969 545 6244267
SGTC_836 0330-0104 1.35 µM 0.000936410322237553 0.499316020242775 no 1682 0.499626426385251 546 46494820
SGTC_1166 k206-0078 225 µM 0.000640363192680907 0.4992218770203 no 1683 0.499744532065086 546 5404595
SGTC_2453 5731132 22.18 µM 0.000186906327889394 0.499077677462742 no 1684 0.499925435163764 546 1362040
SGTC_2381 9035592 200 µM -6.76285702805787e-05 0.498996735262608 no 1685 0.499973020103973 549 4749657
SGTC_1863 st057641 20.1 µM -0.000389595496524958 0.498894349709969 no 1686 0.499844573888114 548 3921635
SGTC_1970 st070122 35.8 µM -0.00153192188838785 0.498531090302427 no 1687 0.499388851827489 549 102928
SGTC_2553 4-methylesculetin 85.09 µM -0.00256860461994278 0.498201426589372 no 1688 0.498975276142279 551 5319502
SGTC_1185 1319-0113 81.3 µM -0.00321480040323357 0.497995937807262 no 1689 0.498717482405223 550 4672763
SGTC_2297 7971671 152.32 µM -0.00461704239927163 0.497550029959463 no 1690 0.498158073120611 552 909016
SGTC_669 0108-0021 26.2 µM -0.00462884435189866 0.497546276993717 no 1691 0.498153364873028 554 17201
SGTC_2406 ethylparaben 405.7 µM -0.00732098266036518 0.496690195932485 no 1692 0.497079376572057 568 8434 A possible steroid mimic.
SGTC_1394 3474-0001 65.7 µM -0.007332924586406 0.496686398514974 no 1693 0.497074612560727 552 5017666 YIL048W NEO1
SGTC_650 1328-0195 38 µM -0.00778099677835473 0.496543916091724 no 1694 0.496895862724247 550 2780821
SGTC_2366 9070441 60.58 µM -0.00785955611103339 0.496518935063739 no 1695 0.49686452304326 556 6837235
SGTC_1759 st043059 70 µM -0.00786324922072452 0.496517760694672 no 1696 0.496863049751185 553 669426
SGTC_2390 9097792 176.6 µM -0.00985056965846676 0.495885818861962 no 1697 0.496070254830268 549 4497149
SGTC_2737 bleomycin 30.5 nM -0.0111437048419981 0.495474624280116 no 1698 0.495554396989166 551 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_2135 5326629 150.42 µM -0.0121484818060042 0.495155125912501 no 1699 0.495153576175593 557 5020077
SGTC_833 3852-0053 558 µM -0.0124395485659411 0.49506257325274 no 1700 0.495037466113977 553 3123681
SGTC_2875 9039966 71.43 µM -0.0133313858053649 0.494778990817018 no 1701 0.494681704079471 565 6463691
SGTC_699 0375-0592 111 µM -0.0133967481035068 0.494758207306418 no 1702 0.494655630623644 556 762578
SGTC_1396 3511-0007 98.6 µM -0.0140893065267942 0.494537992627842 no 1703 0.49437936588287 552 X1396
SGTC_2479 5617353 43.85 µM -0.0142761880812434 0.494478569675927 no 1704 0.494304818427481 556 2731746
SGTC_2334 9017922 200 µM -0.0152709215604408 0.494162275172607 no 1705 0.493908020505764 560 3163164
SGTC_763 3453-1109 128 µM -0.0156609164642259 0.49403826983681 no 1706 0.493752453656981 553 1560353
SGTC_2708 st078559 56 µM -0.0163878230059774 0.493807139415144 no 1707 0.493462497139927 553 17250902
SGTC_50 0929-0078 56.389 µM -0.0186650821074642 0.49308306584661 no 1708 0.492554141920583 555 1377751
SGTC_693 4161-2696 114 µM -0.0188321541349923 0.493029944767085 no 1709 0.492487501538439 559 805759
SGTC_3069 9117009 49.47 µM -0.0188735619283548 0.493016779047308 no 1710 0.492470985154402 558 41904981
SGTC_2508 celastrol 40.54 µM -0.0191895355246556 0.492916314640198 no 1711 0.492344952754396 556 122724 Celastrol is a natural product and antioxidant.
SGTC_373 0844-0104 25.9 µM -0.0206133109623325 0.49246362819257 no 1712 0.491777061055084 562 5375804
SGTC_3312 9133330 71.43 µM -0.0216458738945864 0.492135332988182 no 1713 0.491365220007997 558 17617324
SGTC_2895 9054447 58.44 µM -0.0232812251349645 0.491615397004705 no 1714 0.490712973913623 555 2697450
SGTC_228 caffeine 993.056 µM -0.0242847845137342 0.491296336990493 no 1715 0.490312724876034 564 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_3033 9090887 49.47 µM -0.025600100763231 0.490878169081685 no 1716 0.489788152849997 555 19325384
SGTC_2733 amorolfine 100 µM -0.0271887903184655 0.49037310320799 no 1717 0.489154578216222 558 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_2981 9013952 38.96 µM -0.0274884048964626 0.490277853391138 no 1718 0.48903509395323 558 2996344
SGTC_1904 st060225 78 µM -0.0279846690826817 0.490120088348636 no 1719 0.488837189329317 555 66595
SGTC_3096 9117468 49.47 µM -0.0281153052914979 0.490078558654235 no 1720 0.488785093520875 564 41316311
SGTC_1196 1588-0294 184 µM -0.028461562014889 0.489968482987606 no 1721 0.488647012334517 563 6144269
SGTC_1461 k072-0203 53.8 µM -0.0292439290922658 0.48971976984183 no 1722 0.488335022926158 557 5418714
SGTC_3282 9108498 15.4605 µM -0.0293623399435181 0.489682127582148 no 1723 0.488287804108293 568 16459645
SGTC_1508 1080-0625 72.9 µM -0.0308716914446087 0.489202319916344 no 1724 0.487685933056476 553 767111
SGTC_765 1319-0117 244 µM -0.0309835711836831 0.489166755085761 no 1725 0.487641320839568 563 3487746 YGL099W LSG1
SGTC_676 falcarinol 140 µM -0.0318907521409747 0.48887837956153 no 1726 0.487279586806291 566 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_3207 9114163 49.47 µM -0.0335740254772576 0.488343314588358 no 1727 0.486608417626936 581 849233
SGTC_2642 cholecalciferol 100 µM -0.0337517410054563 0.488286825057249 no 1728 0.486537559548146 563 9821465 A vitamin D precursor, similar to steriods.
SGTC_3176 9106582 49.47 µM -0.0349422199260659 0.487908419692231 no 1729 0.486062907260617 566 17018027
SGTC_603 3794-0023 45.9 µM -0.0352993163211132 0.487794915218251 no 1730 0.485920534244597 576 3802260
SGTC_1299 1079-1439 3.74 µM -0.0358324676004747 0.48762545285918 no 1731 0.485707972140823 574 323161
SGTC_425 3825-7017 13.1 µM -0.0363936484455269 0.48744708370492 no 1732 0.485484239316204 557 3397440
SGTC_1486 3970-0793 4.53 µM -0.0373077162740998 0.487156556184043 no 1733 0.485119826540246 574 2844330
SGTC_2301 7769476 200 µM -0.0380724553536128 0.486913496576005 no 1734 0.484814956412793 573 977820
SGTC_144 4161-2749 112.381 µM -0.0390154488108346 0.486613788478625 no 1735 0.484439035810857 561 797501 YMR168C CEP3
SGTC_3266 9136860 49.47 µM -0.0391563513833552 0.486569006584062 no 1736 0.484382866738657 574 4871271 YPR165W RHO1
SGTC_2650 prasterone 100 µM -0.0394367727614703 0.48647988309058 no 1737 0.484271081139062 558 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_2940 9060638 45.86 µM -0.040462743929447 0.486153814828149 no 1738 0.483862104369882 564 4027022
SGTC_679 0422-0091 41.4 µM -0.0435699710516997 0.485166351124143 no 1739 0.482623594293354 564 627384 YHR062C RPP1
SGTC_3240 9133527 49.47 µM -0.0442864019490581 0.484938685083186 no 1740 0.482338055356645 597 17617455
SGTC_2994 9053520 71.4286 µM -0.0444886917185551 0.484874402712579 no 1741 0.482257432877365 577 4647384
SGTC_5 0352-0601 109.883 µM -0.0450279844788461 0.484703031576599 no 1742 0.482042501591102 561 762456
SGTC_264 promethazine 12.5 mM -0.0458966914813271 0.484426988385499 no 1743 0.481696295607781 566 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_533 1222-0222 6.71 µM -0.0466623049554467 0.484183710715707 no 1744 0.481391186944608 590 3982874
SGTC_1594 piperine 70.1 µM -0.0476145386743543 0.483881141716307 no 1745 0.481011722492769 564 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2693 st077581 40.7 µM -0.0477266664702374 0.483845514101045 no 1746 0.48096704077236 577 25238761
SGTC_780 0109-0199 192 µM -0.0491728182470027 0.483386023826657 no 1747 0.480390786475145 569 610414
SGTC_3325 9138760 55.175 µM -0.0505059058511634 0.482962477311317 no 1748 0.479859621612154 585 43844959
SGTC_2764 methyldopa 94.69 µM -0.0513620489032316 0.482690474984328 no 1749 0.47951851271241 578 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_3280 9140961 49.47 µM -0.052025260192754 0.482479773889334 no 1750 0.479254282970813 576 4901226
SGTC_754 3474-0146 171 µM -0.0523310868591564 0.482382614924198 no 1751 0.479132441756644 569 24762078
SGTC_2863 9028737 58.44 µM -0.0526087637460163 0.482294399850683 no 1752 0.479021817091398 596 6460917
SGTC_2762 leflunomide 42.06 µM -0.0526713503559779 0.482274516851909 no 1753 0.478996883216024 575 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.0556479187542209 0.481328949353036 no 1754 0.477811144987265 567 756377
SGTC_726 3448-4391 34.2 µM -0.0556658732586367 0.481323246052835 no 1755 0.477803993261827 577 1356692
SGTC_776 4476-4378 112 µM -0.0575370443833172 0.480728884317657 no 1756 0.477058698910714 578 2892008
SGTC_3056 9094900 49.47 µM -0.0576854397898885 0.480681749583686 no 1757 0.476999595873423 579 25236784
SGTC_1658 st012944 20 µM -0.0591770807986817 0.480207975757796 no 1758 0.476405532258536 584 24207260
SGTC_1638 st008370 60.6 µM -0.0598141133522743 0.480005650467476 no 1759 0.476151842437001 575 24207134
SGTC_1490 4089-0339 670 nM -0.0600575328177466 0.479928340369214 no 1760 0.476054906388872 570 742542
SGTC_2560 caryophyllene 100 µM -0.0602283064142254 0.479874103072121 no 1761 0.475986900686353 563 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_382 3229-0966 23.2 µM -0.0614686607418457 0.479480180666679 no 1762 0.475492986149542 581 5722370
SGTC_921 1561-0023 372 µM -0.0620754510094579 0.479287478266124 no 1763 0.475251373271802 577 24050882
SGTC_1228 0124-0032 52.5 µM -0.062100017781644 0.479279676535384 no 1764 0.475241591419832 598 X1228
SGTC_1259 0671-0132 43 µM -0.0625767269436861 0.479128288400347 no 1765 0.475051781148223 586 X1259
SGTC_3183 9108214 49.47 µM -0.0626942690838724 0.479090961101821 no 1766 0.475004980513158 582 4974831
SGTC_1815 st051655 58.2 µM -0.06286115440027 0.479037964440555 no 1767 0.474938533967918 583 5984156
SGTC_2393 9031399 185.94 µM -0.0635604812774149 0.478815887891184 no 1768 0.474660099727451 597 1526623 YDL150W RPC53
SGTC_840 0245-0196 390 µM -0.0641423645573239 0.478631111455803 no 1769 0.474428434619576 572 3827528
SGTC_2626 ethyl orsellinate 100 µM -0.064343213472716 0.478567333154111 no 1770 0.474348472672669 569 75653 A natural product.
SGTC_1338 1486-1223 76 µM -0.0652902435918008 0.478266617156559 no 1771 0.473971455128414 597 3444526
SGTC_1912 st060209 90.8 µM -0.0679829979308437 0.477411639343318 no 1772 0.472899584327308 580 688787
SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.0722455692559793 0.476058442220214 no 1773 0.471203240436348 593 16486 A toxic proline analog.
SGTC_753 1322-0200 289 µM -0.0730548520341215 0.475801557783158 no 1774 0.470881234233318 588 5403907
SGTC_2934 9036370 36.88 µM -0.0740607057333241 0.475482291374074 no 1775 0.470481040820093 592 6462800
SGTC_2815 7968870 71.43 µM -0.0749167231374871 0.475210596653624 no 1776 0.470140485404502 599 2977326 YHR190W ERG9
SGTC_2939 9044578 71.43 µM -0.0762852059720452 0.474776272516415 no 1777 0.469596097734662 589 2653634
SGTC_2878 9043973 25.97 µM -0.0774584161918346 0.474403947140217 no 1778 0.469129435457777 589 6465167
SGTC_1570 verbenone 133 µM -0.0779390853862159 0.47425141029431 no 1779 0.468938254156872 578 29025 A natural terpanoid with antifungal properties.
SGTC_993 3909-8757 62.7 µM -0.0791629538993854 0.473863041684678 no 1780 0.468451505294602 578 4288324 YLR208W SEC13
SGTC_168 3970-0862 530.542 µM -0.0791897906799323 0.47385452588084 no 1781 0.468440832474068 573 3135186
SGTC_769 0302-0231 76 µM -0.0798002131452428 0.473660830844604 no 1782 0.468198077400523 585 571869 YER009W NTF2
SGTC_621 3584-0052 32.1 µM -0.0798957237323885 0.473630524647658 no 1783 0.468160095462981 595 2273927
SGTC_798 1287-0182 476 µM -0.080007656524292 0.473595007761158 no 1784 0.468115583234498 620 1649755
SGTC_2754 granisetron 64.02 µM -0.0810722778678013 0.473257208123598 no 1785 0.46769223607705 591 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_3101 9120531 49.47 µM -0.081216200831511 0.473211543474783 no 1786 0.467635007838682 606 24824904
SGTC_1288 0973-0013 65.5 µM -0.0813588738789217 0.473166275753571 no 1787 0.467578277266074 585 4315430
SGTC_716 1683-5115 658 µM -0.0816822747949844 0.473063667450228 no 1788 0.467449686958499 584 723597
SGTC_3315 9136395 68.55 µM -0.0818991551320196 0.472994856885233 no 1789 0.467363453145448 585 16876844
SGTC_1689 st020265 53.493 µM -0.0820684024088858 0.472941159627498 no 1790 0.467296159782165 586 5758320 YPR016C TIF6
SGTC_2067 5224629 34.075 µM -0.0824033387239285 0.472834895488456 no 1791 0.46716299058187 593 2835000
SGTC_1277 0873-0036 22 µM -0.0829355388068226 0.47266605010458 no 1792 0.466951397744126 589 5965735
SGTC_318 1488-0629 67.2 µM -0.0843631593923375 0.472213148651266 no 1793 0.466383848688731 595 3662576
SGTC_2031 5180455 200 µM -0.0843649683172444 0.472212574806668 no 1794 0.466383129595661 583 29949
SGTC_2758 dehydroepiandrosterone 69.35 µM -0.0852207353343656 0.471941106632512 no 1795 0.466042953066776 613 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_2397 5161689 200 µM -0.0853159321812044 0.471910908896213 no 1796 0.466005112832255 607 2259942
SGTC_2843 9000894 45.46 µM -0.0863791626192194 0.471573648733973 no 1797 0.465582505415631 580 2242070
SGTC_1997 st073024 93.8 µM -0.0866656846463776 0.471482766489162 no 1798 0.465468626719217 583 686268
SGTC_1153 4055-0057 267 µM -0.0875114535826405 0.471214504765985 no 1799 0.465132490858672 585 882706
SGTC_896 0964-0007 44.5 µM -0.0885140692414503 0.470896511191477 no 1800 0.464734051295847 586 6756758
SGTC_101 0490-5701 117.494 µM -0.089492628058267 0.470586165472507 no 1801 0.464345206017146 590 4661669
SGTC_1642 st009582 77.7 µM -0.0900349197349905 0.470414187681071 no 1802 0.464129732784211 599 6739311
SGTC_1028 k015-0029 4.8 µM -0.0909617840291111 0.470120262578436 no 1803 0.463761478526325 579 4588309
SGTC_863 0466-0191 129 µM -0.0916217523814052 0.469910984824754 no 1804 0.463499284119831 594 765160 YPR165W RHO1
SGTC_468 gf-109203x 121 µM -0.0919509287154869 0.469806605219779 no 1805 0.463368513777438 594 2396 A protein kinase C inhibitor.
SGTC_1023 4482-3888 16 µM -0.0924978542779345 0.469633183387707 no 1806 0.463151247976057 589 3303168
SGTC_1068 loratadine 26.9 µM -0.0928349380430513 0.469526302086075 no 1807 0.463017347153967 600 3957 A H1 histamine antagonist.
SGTC_2818 7996756 12.99 µM -0.0932382017904849 0.469398439560331 no 1808 0.462857162959835 576 2241621
SGTC_3156 9099931 49.47 µM -0.0960896177259067 0.468494434110967 no 1809 0.461724698502643 591 18111053
SGTC_115 0527-0192 112.043 µM -0.0961596744905786 0.468472225522846 no 1810 0.461696878721207 605 4233931
SGTC_2983 9022671 12.99 µM -0.0965466194405705 0.468349562463779 no 1811 0.461543224934855 606 6405161
SGTC_2280 7785178 200 µM -0.0972554654614269 0.468124863311363 no 1812 0.461261760847041 590 2954328
SGTC_817 1391-0715 46 µM -0.100170077118727 0.467201059618446 no 1813 0.460104650751864 591 1353946
SGTC_3233 9132340 49.47 µM -0.100387299174701 0.467132216793043 no 1814 0.4600184263099 627 17682950
SGTC_2234 tolnaftate 200 µM -0.100811942923778 0.466997639951364 no 1815 0.459849873030603 595 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_912 3474-0017 2.18 µM -0.102238747662395 0.466545488933061 no 1816 0.459283586346148 595 3360550
SGTC_2731 amoxapine 43.43 µM -0.10345772906709 0.466159230808653 no 1817 0.458799848364316 580 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_460 trequinsin 123 µM -0.104271459407272 0.465901402136334 no 1818 0.458476963259844 580 5537 A vasodilator.
SGTC_2124 5246320 200 µM -0.104353844877986 0.465875299276767 no 1819 0.458444274542045 615 579342
SGTC_1946 st076057 65.1 µM -0.10626346678069 0.465270299589317 no 1820 0.45768665835733 595 953009
SGTC_843 0310-0051 143 µM -0.106322575340259 0.465251574297119 no 1821 0.45766321028919 595 2065037
SGTC_3271 9137798 49.47 µM -0.106387714490994 0.465230938633314 no 1822 0.457637370086565 594 6498326
SGTC_751 0833-0568 350 µM -0.106966342607824 0.465047637079724 no 1823 0.457407840613374 590 6954252
SGTC_1494 4358-1428 177 µM -0.108354667792726 0.464607864775852 no 1824 0.456857179603946 624 1564571
SGTC_81 0411-0046 9.971 µM -0.110890548815773 0.463804699356428 no 1825 0.455851570165418 590 12925265
SGTC_2638 epoxomicin 18 µM -0.112510159811663 0.463291812380619 no 1826 0.455209457263649 608 9915668 A protesome inhibitor.
SGTC_1157 4092-0394 27.6 µM -0.112875029172486 0.46317627651744 no 1827 0.455064816811184 596 3659885
SGTC_1069 diphenylcyclopropenone 8.49 µM -0.114084617189383 0.462793282807463 no 1828 0.454585358153872 635 65057 A dermal irritant. YDR527W RBA50
SGTC_969 1313-0238 134 µM -0.11742260242503 0.461736551401636 no 1829 0.453262586911683 598 5212874
SGTC_463 ikarugamyin 104 µM -0.117892635214101 0.461587771062799 no 1830 0.453076364400326 598 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_781 4335-2806 94.4 µM -0.119658307431678 0.46102892779824 no 1831 0.452376914416282 642 845254
SGTC_3070 9117005 49.47 µM -0.123946422720498 0.459672042408814 no 1832 0.450678848149126 596 8779016
SGTC_1864 st057645 30.4 µM -0.123960963152574 0.459667442179774 no 1833 0.450673091748455 594 688666
SGTC_1790 st045711 43.5 µM -0.125005672927166 0.459336936304926 no 1834 0.450259529612316 602 585119
SGTC_3009 9080819 71.4286 µM -0.125060738395627 0.459319516492388 no 1835 0.450237732715137 622 17027216
SGTC_454 lyso-paf C-16 6.67 µM -0.129740227848648 0.457839461349911 no 1836 0.448385977155274 626 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_352 k048-0007 5.11 µM -0.130320687184865 0.457655910746459 no 1837 0.448156356816932 637 6811911
SGTC_1013 4112-3890 241 µM -0.1305430923397 0.457585585040591 no 1838 0.448068381528114 596 705171
SGTC_984 1492-0255 2.91 µM -0.13146334497745 0.457294610348141 no 1839 0.44770439067116 614 1585198
SGTC_1608 st001473 40.5 µM -0.134054358739719 0.456475481137249 no 1840 0.446679795121768 647 7292267
SGTC_2828 7998861 71.43 µM -0.135170954149965 0.456122534841412 no 1841 0.446238355764471 595 2988188
SGTC_1708 st033234 31.827 µM -0.137939497729584 0.455247571721543 no 1842 0.445144117046324 604 674664
SGTC_1302 1159-0335 255 µM -0.139616258260779 0.454717758059618 no 1843 0.444481597104765 627 649284
SGTC_1762 st045503 25.4615 µM -0.139855535973515 0.454642158936172 no 1844 0.444387066536177 625 4645554
SGTC_1989 st071868 50.2 µM -0.143954824482965 0.453347257647531 no 1845 0.442768071408859 604 16414057
SGTC_795 0685-0265 78 µM -0.144014597395448 0.453328379951549 no 1846 0.442744471372375 608 302754
SGTC_2949 9072542 2.23 µM -0.145027774820471 0.453008410695855 no 1847 0.442344471241094 650 16457352
SGTC_1998 st075797 76.8 µM -0.148729907085463 0.451839509682788 no 1848 0.440883380627344 625 24208315
SGTC_1389 3405-0187 19 µM -0.150088970406603 0.451410506983365 no 1849 0.44034721087753 616 799890
SGTC_1520 flindersine 88 µM -0.1501798151764 0.451381832889427 no 1850 0.440311375216275 636 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_3038 9091290 49.47 µM -0.15040064160457 0.451312132656385 no 1851 0.440224267550736 608 25236843
SGTC_659 k018-0002 107 µM -0.15061422242831 0.451244720807259 no 1852 0.440140020753968 629 6797879 YHR007C ERG11
SGTC_2840 9008771 71.43 µM -0.151105821566363 0.451089564250813 no 1853 0.439946120143972 586 2992978
SGTC_2572 astragaloside iv 100 µM -0.151839826078858 0.450857914593631 no 1854 0.439656634816595 615 45006101 An anti-inflammatory agent.
SGTC_1331 1472-0049 76.2 µM -0.152843173153796 0.450541288310781 no 1855 0.439260975224954 613 24051409
SGTC_2724 maprotiline 69.64 µM -0.153090063113439 0.45046338205224 no 1856 0.439163625997014 591 4011 A tricyclic antidepressant.
SGTC_1654 st012436 41.8 µM -0.154235535734673 0.45010195257282 no 1857 0.438712011972975 630 4323132
SGTC_2073 5212005 126 µM -0.154804703292225 0.449922379248178 no 1858 0.438487641611043 618 691789
SGTC_2337 9009472 200 µM -0.155180051516314 0.449803961858463 no 1859 0.438339687178934 616 5742383
SGTC_1135 dihydrocapsaicin 536.708 nM -0.156055685589362 0.449527728308204 no 1860 0.437994564048229 646 107982 A Capsaicinoid.
SGTC_2576 guaiol 23.12 µM -0.158819094728376 0.448656125253358 no 1861 0.436905702168845 619 227829
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.159652117173446 0.448393431203355 no 1862 0.43657756095814 608 2333 A French combination drug.
SGTC_1928 4'-methoxychalcone 40.3 µM -0.160035867955986 0.448272422805433 no 1863 0.436426409896051 610 641818
SGTC_1214 0358-0031 63.7 µM -0.160280653522319 0.448195236918099 no 1864 0.436329999048864 682 4301366
SGTC_2246 7293507 91.5585 µM -0.163475619364923 0.447187979865652 no 1865 0.435071983920456 602 887656
SGTC_845 0330-0138 4.51 µM -0.165468967071242 0.446559721600682 no 1866 0.434287436900273 616 9039800
SGTC_2665 lovastatin 100 µM -0.167797441446958 0.445826008898336 no 1867 0.43337131769542 625 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_2119 5528445 120.635 µM -0.168315112273515 0.445662913616678 no 1868 0.433167692796577 625 791935
SGTC_2219 9098279 200 µM -0.168540846198561 0.445591797674425 no 1869 0.433078906310418 613 902349
SGTC_265 mycophenolic acid 32.932 µM -0.169904579128159 0.445162200178144 no 1870 0.432542589930434 623 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_1991 st073000 8.92 µM -0.171467088103297 0.444670064258192 no 1871 0.431928253526769 642 4301969 YIL048W NEO1
SGTC_172 1112-0046 2.638 µM -0.173563339837287 0.444009952037606 no 1872 0.43110432261624 650 2802135 YIL048W NEO1
SGTC_2954 9074818 52.69 µM -0.173709362469729 0.44396397509787 no 1873 0.431046939604252 652 16648742
SGTC_2910 7948405 25.97 µM -0.174716716816328 0.443646818338074 no 1874 0.430651115849493 612 2971328
SGTC_292 k038-0015 474 µM -0.174718948414747 0.443646115778701 no 1875 0.430650239055826 637 46368540
SGTC_2919 7978188 46.38 µM -0.174970870949044 0.443566805812373 no 1876 0.430551261043308 600 2980291
SGTC_108 0509-0257 621.132 µM -0.176421956315944 0.443110020869089 no 1877 0.429981228272861 618 536624
SGTC_2055 5235184 200 µM -0.176630378490183 0.443044418166296 no 1878 0.4298993653294 643 2836034
SGTC_742 0kpi-0133 140 µM -0.176725186997695 0.44301457687563 no 1879 0.429862127949459 650 2728852
SGTC_3310 9130229 44.1445 µM -0.179174395897682 0.442243792801109 no 1880 0.428900383746458 646 7761258
SGTC_599 1935-0052 86.5 µM -0.179624890923299 0.44210204241518 no 1881 0.428723531188835 630 9557311
SGTC_1097 itavastatin 7.23 µM -0.181074350937556 0.441646013368305 no 1882 0.428154608387118 622 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_2702 st077768 96.8 µM -0.183656024115012 0.440833959400208 no 1883 0.427141654832737 610 6484119
SGTC_2272 7805186 180 µM -0.184115829415084 0.440689355657595 no 1884 0.426961294340918 681 2956062 YPR165W RHO1
SGTC_1435 4092-0789 56.7 µM -0.184311189910806 0.440627919309159 no 1885 0.426884668014507 617 2248285
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.184737185164069 0.440493958632082 no 1886 0.42671758929507 634 6708739 YPR165W RHO1
SGTC_2834 9001755 58.44 µM -0.18548373814369 0.440259210143982 no 1887 0.426424817020182 665 2989575
SGTC_732 3970-1727 52.7 µM -0.185554472392125 0.440236969330112 no 1888 0.426397079592746 646 1275699
SGTC_2923 7992654 58.14 µM -0.18677752685841 0.439852436886337 no 1889 0.425917533897923 604 2985126
SGTC_1499 4480-0877 67.3 µM -0.187146569462529 0.439736419773995 no 1890 0.425772857985624 605 2861909
SGTC_3005 9076496 71.4286 µM -0.189117812145985 0.439116801749178 no 1891 0.425000240658778 638 21368410
SGTC_2760 etidronate 98.04 µM -0.189491104568181 0.438999482001822 no 1892 0.424853963165242 623 3305 A chelator and antioxidant.
SGTC_1129 3453-1384 223 µM -0.190207084403336 0.438774476168906 no 1893 0.424573429956206 698 1084452
SGTC_3267 9137951 49.47 µM -0.190635598218895 0.438639819673805 no 1894 0.424405549140888 612 16643986
SGTC_1034 k072-0165 12.7 µM -0.191262907402061 0.438442706390051 no 1895 0.424159810096772 684 5835461
SGTC_2486 5283202 22.39 µM -0.192253693859106 0.438131412287279 no 1896 0.42377174432766 635 1377751
SGTC_1649 st011737 51.3 µM -0.192736169045992 0.437979837788023 no 1897 0.423582797847452 618 1761035
SGTC_3079 9117512 49.47 µM -0.193982151079959 0.437588441971635 no 1898 0.423094928908328 640 7185044
SGTC_2076 5212012 200 µM -0.194671963056381 0.437371780073317 no 1899 0.422824881100952 624 604802
SGTC_923 1900-2434 73.3 µM -0.195304192961716 0.437173220523465 no 1900 0.42257740738511 645 5910570
SGTC_1796 st049173 110.4 µM -0.196108370060145 0.436920681721146 no 1901 0.422262672552469 632 94134
SGTC_2123 5259487 200 µM -0.19618524408899 0.436896542020912 no 1902 0.422232588573354 626 2173474
SGTC_1126 isoteolin 1.0172 µM -0.19626917802139 0.43687018566401 no 1903 0.422199742280835 617 133323
SGTC_687 k029-0044 34.9 µM -0.19700340075746 0.43663964204324 no 1904 0.421912438258095 635 5829338
SGTC_276 colchicine 750 µM -0.197294840492991 0.436548136848366 no 1905 0.421798408343722 668 2833 A microtubule depolymerizer.
SGTC_552 k242-0005 476 µM -0.197871579285334 0.436367064499278 no 1906 0.421572770476772 657 4088318
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.198621181415757 0.436131740078357 no 1907 0.421279541673258 640 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_963 1269-2853 151 µM -0.198919950310636 0.436037953128404 no 1908 0.42116268163763 616 3668223
SGTC_1737 st035557 69.7 µM -0.200168447326973 0.435646074707921 no 1909 0.420674421574228 618 5716916
SGTC_821 1114-0266 29.2 µM -0.200377141860691 0.435580575791069 no 1910 0.420592817557072 643 3123235
SGTC_1996 st072960 66.8 µM -0.201423700672903 0.435252139304907 no 1911 0.420183642256229 622 1719405
SGTC_2959 9079155 11 µM -0.203238004245151 0.434682871151158 no 1912 0.419474504776231 637 16189457
SGTC_2240 6690706 185.951 µM -0.204757724400475 0.434206137628685 no 1913 0.418880709089302 616 805876
SGTC_2085 5307070 144.047 µM -0.204833444945492 0.434182386724253 no 1914 0.418851127849352 661 2840351
SGTC_2692 st077426 47.7 µM -0.205793700387087 0.433881208591354 no 1915 0.418476031121932 663 25238571
SGTC_643 k048-0106 28.4 µM -0.205840648015703 0.433866484743038 no 1916 0.418457694251552 635 6763920
SGTC_1810 st050138 53 µM -0.206060677855307 0.43379747958443 no 1917 0.418371757051393 662 3444541
SGTC_1411 3909-8223 150 µM -0.207306450751072 0.433406821795962 no 1918 0.417885268303286 642 X1411
SGTC_1348 1493-0373 93.8 µM -0.208760080767455 0.432951065049183 no 1919 0.417317767803925 672 3010129
SGTC_3228 9131799 49.47 µM -0.208776447191186 0.432945934189416 no 1920 0.417311379292577 635 17015818
SGTC_1518 st038567 90.8 µM -0.211277711723647 0.432161923291367 no 1921 0.41633528691946 645 77966
SGTC_140 0062-0056 502.533 µM -0.211873589756644 0.431975187091247 no 1922 0.416102827579423 642 3758964
SGTC_1136 pergolide 1.05886 µM -0.21200260858269 0.431934757184136 no 1923 0.416052499612791 634 47811 A dopamine receptor agonist.
SGTC_914 3820-6779 408 µM -0.212069281246365 0.431913864624189 no 1924 0.416026492323018 634 2893481
SGTC_1316 1272-0050 65.9 µM -0.212194531988146 0.431874616540268 no 1925 0.415977636227275 643 7340392
SGTC_2891 9063876 19.48 µM -0.212576414093732 0.431754955605244 no 1926 0.415828684898024 621 6472478
SGTC_2886 9058944 51.95 µM -0.21271555760969 0.431711357204488 no 1927 0.415774415624711 624 4949929
SGTC_972 1319-0219 195 µM -0.213886078574236 0.431344626117466 no 1928 0.415317948359015 643 23903702
SGTC_925 2064-1272 59.6 µM -0.214195830788998 0.431247588819764 no 1929 0.415197173593554 665 6815817
SGTC_2438 5259590 200 µM -0.214291924906015 0.431217485879898 no 1930 0.415159707387918 650 1201127
SGTC_1062 mesoridazine 14.2 µM -0.215300795767743 0.430901465927786 no 1931 0.414766404621253 628 4078 A neuroleptic.
SGTC_2094 5332512 191.667 µM -0.215676668101262 0.430783738515031 no 1932 0.414619894676034 660 755774
SGTC_2589 lobaric acid 100 µM -0.216506624857737 0.43052380858887 no 1933 0.414296430865748 650 73157 A novel microtubule depolymerizer.
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.217529422879691 0.430203525102521 no 1934 0.413897889887819 645 4620898
SGTC_1429 4049-0205 9.46 µM -0.218722936085442 0.429829841176695 no 1935 0.41343294057004 641 22774478
SGTC_973 1325-0077 65.9 µM -0.219326002005043 0.429641047675289 no 1936 0.413198054144087 657 2835149
SGTC_830 4076-0286 57.8 µM -0.221423987953669 0.428984385866266 no 1937 0.412381158125505 635 6866659
SGTC_2269 7935389 174.42 µM -0.221809918186223 0.428863612481987 no 1938 0.412230929090079 618 97605
SGTC_282 k297-0036 65.7 µM -0.224548883144134 0.428006670121813 no 1939 0.411165117309823 661 5061378
SGTC_2227 7312221 64.1025 µM -0.225027897554831 0.427856835223528 no 1940 0.410978785831441 629 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_1993 st073995 70.8 µM -0.227162125466581 0.427189379059133 no 1941 0.410148838671527 640 3098394
SGTC_979 1426-2828 121 µM -0.22722235671664 0.427170545416578 no 1942 0.410125422084208 656 747872
SGTC_1691 st019933 84.6 µM -0.228024792551738 0.426919648502093 no 1943 0.409813483260403 667 6176082
SGTC_1560 lithocholic acid 53.1 µM -0.229358950793502 0.426502563890121 no 1944 0.40929496914446 632 9903 A bile acid which acts as a detergent.
SGTC_1123 mangostin 811.285 nM -0.229379088286469 0.426496269134521 no 1945 0.40928714401882 639 5281650 An antioxidant.
SGTC_96 0929-0093 37.281 µM -0.230459665027728 0.426158520401142 no 1946 0.408867301301698 647 6991579
SGTC_2495 cafestol 54.53 µM -0.230717500398215 0.426077938496011 no 1947 0.408767138467937 677 16667697 An anti-infammatory.
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.230887377558321 0.426024848067268 no 1948 0.408701148536857 627 4000243
SGTC_1250 0485-0349 40.2 µM -0.23270049635796 0.425458291422123 no 1949 0.40799699187832 676 6842794 YDL195W SEC31
SGTC_812 4251-0442 148 µM -0.232715951025923 0.425453462864506 no 1950 0.407990991059083 677 5723007
SGTC_114 0364-0001 490.298 µM -0.232911951273717 0.425392226770899 no 1951 0.407914888931604 655 4003655
SGTC_3095 9117207 49.47 µM -0.233587121160257 0.425181298138771 no 1952 0.407652763504468 648 17015229
SGTC_1948 st076329 66.6 µM -0.233685285334707 0.425150632624075 no 1953 0.407614656052407 667 24208413
SGTC_1367 1812-0510 76.9 µM -0.234091601505612 0.425023708299967 no 1954 0.407456932921333 646 1142582 YDR527W RBA50
SGTC_1195 1502-0147 41.1 µM -0.236705521653396 0.424207362937176 no 1955 0.406442625512943 653 817940
SGTC_3117 9124945 49.47 µM -0.238359334552881 0.423691033389746 no 1956 0.405801202425997 652 17592065
SGTC_26 0302-0163 425.158 µM -0.238590969353651 0.423618726159799 no 1957 0.405711384168957 678 3100915
SGTC_1272 0839-0021 27 µM -0.239698118005784 0.423273153674319 no 1958 0.405282147016242 671 5027250
SGTC_2831 7999036 19.48 µM -0.239958117053136 0.423192009147114 no 1959 0.405181362909889 706 2988270
SGTC_837 0091-0265 12.5 µM -0.240995601679042 0.422868247357447 no 1960 0.404779262715158 646 759367
SGTC_2159 5658611 73.75 µM -0.242076676447077 0.422530938066912 no 1961 0.404360375147667 673 793844
SGTC_337 1315-0038 354 µM -0.242869722019412 0.422283533707644 no 1962 0.404053160861634 676 1626437
SGTC_2095 5432005 200 µM -0.244157926569933 0.4218817212872 no 1963 0.403554255402569 661 783734
SGTC_2690 usnic acid 100 µM -0.244755805656671 0.421695260458539 no 1964 0.403322757593246 694 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_1413 3910-0535 34.4 µM -0.244929942704381 0.421640955555806 no 1965 0.403255338378078 655 2876951
SGTC_2905 7799065 20.05 µM -0.244934733185342 0.421639461658101 no 1966 0.403253483727413 700 1296806
SGTC_2741 miltefosine 3.04 µM -0.245259052574972 0.421538326213382 no 1967 0.403127927458002 643 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_2161 5662504 8.5105 µM -0.245810985902731 0.421366223760617 no 1968 0.402914276213299 624 2859334
SGTC_737 1950-0117 57.9 µM -0.247134270152543 0.42095366185801 no 1969 0.402402156192299 654 5393513
SGTC_3220 9131269 49.47 µM -0.249250884674243 0.420293943047704 no 1970 0.401583360427454 657 17722206
SGTC_1466 k213-0079 57.5 µM -0.249409865422672 0.420244400012545 no 1971 0.401521877362906 668 3657981
SGTC_1885 st057546 99.9 µM -0.25105315130157 0.419732378407183 no 1972 0.400886507965185 651 702008
SGTC_2020 4017018 200 µM -0.252460251057414 0.419294056553233 no 1973 0.400342667127909 682 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_418 lividomycin a 100 µM -0.252533060872553 0.419271378484065 no 1974 0.400314531548251 654 72394 An antibiotic.
SGTC_2180 6301957 200 µM -0.252809294945478 0.419185342311777 no 1975 0.400207792324522 681 845462
SGTC_2744 captopril 92.04 µM -0.253011166606588 0.419122469582742 no 1976 0.400129792090478 653 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_1619 st003326 88.7 µM -0.255191335305717 0.418443590117302 no 1977 0.399287661501195 626 2849032
SGTC_1380 2291-0730 164 µM -0.255703764696324 0.418284060671664 no 1978 0.399089793992588 671 2999191
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.255718941459554 0.418279336048693 no 1979 0.399083934090811 670 4174840
SGTC_2086 5274770 176.623 µM -0.256322876729339 0.418091336733395 no 1980 0.398850767047073 657 689278
SGTC_3008 9078912 71.4286 µM -0.256473632310918 0.418044410869248 no 1981 0.398792569029387 688 16648731
SGTC_286 k060-0067 22.9 µM -0.257687679046887 0.417666555722972 no 1982 0.398323977876478 650 5985051
SGTC_2278 7948257 134.34 µM -0.258478293028691 0.417420528968347 no 1983 0.398018899759698 646 1247028
SGTC_1897 st060201 15 µM -0.259264025604786 0.417176053257047 no 1984 0.397715767016846 656 611878
SGTC_1507 4075-3230 155 µM -0.259444171224408 0.417120006597899 no 1985 0.397646276192985 661 659771
SGTC_52 0329-0193 875 nM -0.260360102667541 0.416835069331781 no 1986 0.397293007692666 682 3739292
SGTC_3107 9121808 49.47 µM -0.260811526663368 0.416694651826428 no 1987 0.397118927512761 643 662681
SGTC_1935 st074532 41.6 µM -0.260816467255935 0.416693115091204 no 1988 0.397117022412242 671 2829742
SGTC_565 1418-0001 44.5 µM -0.263545895222263 0.41584434172902 no 1989 0.396064927066625 697 2862145
SGTC_1027 k015-0025 8.67 µM -0.264067356955089 0.415682226699284 no 1990 0.395864008360126 644 3598955
SGTC_1065 prochlorperazine maleate 2.48 µM -0.264431309434224 0.415569087555217 no 1991 0.395723794207722 665 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_2652 actinonin 100 µM -0.264617503965038 0.415511209380651 no 1992 0.395652067234219 653 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_2529 gangaleoidin 93.61 µM -0.26478734179066 0.415458417251693 no 1993 0.395586644370589 640 4565183
SGTC_3143 9086658 49.47 µM -0.268646695447617 0.414259194827221 no 1994 0.394100787490609 668 25236626
SGTC_1144 3486-0183 12.5 µM -0.269893636711094 0.41387190122537 no 1995 0.39362104137515 705 6744069
SGTC_3351 9150312 21.596 µM -0.270089907455357 0.413810948152197 no 1996 0.39354554318072 669 4904905
SGTC_1182 1222-0449 220 µM -0.273411312845176 0.412779781546587 no 1997 0.392268528788184 654 658318
SGTC_760 0568-0725 82.9 µM -0.275181224482635 0.412230538372657 no 1998 0.391588505512472 686 3916171
SGTC_2134 5324836 1.464 µM -0.276619666717881 0.411784284109117 no 1999 0.391036080950227 646 699272
SGTC_88 0180-0332 8.668 µM -0.276971047385426 0.411675291052648 no 2000 0.390901168805618 651 3101745
SGTC_3040 9091894 49.47 µM -0.277043597191269 0.411652788030527 no 2001 0.390873315037953 659 25236966
SGTC_3289 9119912 71.43 µM -0.277054487487959 0.411649410174931 no 2002 0.390869134016591 725 17014829
SGTC_1048 3161-0300 24.5 µM -0.277618193411372 0.411474573820371 no 2003 0.390652732309651 648 2165101
SGTC_2341 7987486 176.74 µM -0.27789645515054 0.411388275957395 no 2004 0.390545922574361 673 1258686
SGTC_548 1436-0017 110 µM -0.278095464061731 0.41132655955975 no 2005 0.390469538807949 681 9677137
SGTC_1840 st055363 71 µM -0.278852876708793 0.41109169176586 no 2006 0.390178866737436 680 676033
SGTC_1656 st012921 11 µM -0.278952119778147 0.411060919618381 no 2007 0.390140784793719 669 6732821
SGTC_2837 9008476 45.46 µM -0.279459359504983 0.410903649118944 no 2008 0.389946161228087 720 2992805
SGTC_1323 1348-1351 11.2 µM -0.282049219753508 0.410100882497133 no 2009 0.388952884882553 676 6989654
SGTC_1784 st039334 36.3 µM -0.28246326635398 0.409972577278706 no 2010 0.388794154715842 661 3496984
SGTC_1521 st012942 49.4 µM -0.283434183479665 0.409671746229258 no 2011 0.388422013812346 667 24207259
SGTC_456 gingerol 170 µM -0.285027968494027 0.409178039807945 no 2012 0.387811357258771 706 442793 A herb.
SGTC_338 4055-0136 114 µM -0.285919465878206 0.408901943630131 no 2013 0.387469902115646 659 2900563
SGTC_2653 dihydrofissinolide 100 µM -0.290424827478745 0.407507330049112 no 2014 0.385745626115125 672 6857746
SGTC_1139 k015-0024 46.9 µM -0.292262848128815 0.406938714795467 no 2015 0.385042831102399 714 2766652
SGTC_2384 9036245 200 µM -0.29279752007355 0.40677334394167 no 2016 0.38483846196147 687 6462766
SGTC_625 k213-0058 121 µM -0.292851249140581 0.406756726779295 no 2017 0.38481792671916 663 3655420
SGTC_260 nsc-65238 3.989 µM -0.293743978680357 0.406480650693739 no 2018 0.384476772933728 673 3246252
SGTC_1687 st020778 55.3625 µM -0.294796115054215 0.406155337817863 no 2019 0.384074817181988 669 4259299
SGTC_1611 st001856 99.4 µM -0.295133804206464 0.406050940521555 no 2020 0.383945833602795 705 647478
SGTC_2742 clothiapine 36.27 µM -0.29531143700848 0.405996027655888 no 2021 0.383877990225243 682 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_3016 9080866 49.47 µM -0.295470334719863 0.405946908066363 no 2022 0.383817305364933 705 17066299
SGTC_1251 0490-5699 265 µM -0.29748774972732 0.405323399388211 no 2023 0.383047079600463 684 3883818
SGTC_1603 st002045 67.8 µM -0.298769214841208 0.404927470359078 no 2024 0.382558070826959 685 5887985
SGTC_2502 avocadyne acetate 18.59 µM -0.299175480285447 0.404801968482981 no 2025 0.382403078443345 654 3952079
SGTC_1006 4099-6547 255 µM -0.300725833464633 0.404323129744411 no 2026 0.381811783932921 680 3146833
SGTC_3022 9087993 49.47 µM -0.301309777588396 0.404142811132811 no 2027 0.381589142869412 662 17173644
SGTC_2595 hexamethylquercetagetin 100 µM -0.30158154503251 0.404058897839522 no 2028 0.381485539128709 720 386331
SGTC_2523 spermine 47.74 µM -0.302664877702536 0.403724442477037 no 2029 0.381072633287613 671 1103 A DNA binding polyamine.
SGTC_2849 9019321 12.99 µM -0.302991769665313 0.403623535516782 no 2030 0.380948066914255 654 16489627
SGTC_2798 7813637 45.45 µM -0.303569968833117 0.40344506926179 no 2031 0.380727766925753 703 956368
SGTC_3139 9095020 49.47 µM -0.303943473997914 0.403329794296093 no 2032 0.380585478065116 642 25236292
SGTC_1713 st033146 12.748 µM -0.304783022565796 0.40307071494387 no 2033 0.380265706374324 718 674619
SGTC_2998 9066762 71.4286 µM -0.30523890413818 0.402930050604565 no 2034 0.380092102055287 698 4945196
SGTC_938 3126-1755 342 µM -0.305431948087026 0.402870489798306 no 2035 0.380018596243033 693 1777771
SGTC_1047 2043-3044 82 µM -0.305458088943211 0.402862424603632 no 2036 0.380008642858986 743 669592
SGTC_1859 st055998 20 µM -0.305797275677244 0.402757779636095 no 2037 0.379879501434727 702 676301
SGTC_1553 gossypol 38.6 µM -0.30626288468129 0.402614142559787 no 2038 0.379702248009688 666 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1358 1509-0022 2.48 µM -0.30676244592834 0.402460046075355 no 2039 0.379512097358748 679 3258434
SGTC_1637 st007924 17.4 µM -0.307644918101832 0.402187872534821 no 2040 0.379176268512792 650 683336
SGTC_2268 7933382 153.85 µM -0.313153548155381 0.400489968465056 no 2041 0.377082003954863 659 935025 YOR257W CDC31
SGTC_2876 9059903 25.97 µM -0.314645642381998 0.4000303879515 no 2042 0.376515360182666 667 6916095
SGTC_2545 solidagenone 89.61 µM -0.315364004439467 0.399809174304145 no 2043 0.376242646864094 651 6708572 An anti ulcer agent
SGTC_1131 3454-3128 32.3 µM -0.315773741480214 0.399683013570095 no 2044 0.376087125176242 649 710982
SGTC_2451 5856223 45.7 µM -0.318637124115518 0.398801652209959 no 2045 0.375000849340333 667 2179896
SGTC_802 4112-3352 742 µM -0.318743690688377 0.398768860493045 no 2046 0.374960440460219 661 704594
SGTC_67 0335-0847 266 µM -0.320168918894334 0.398330370732128 no 2047 0.374420141589973 739 4552207 YOR254C SEC63
SGTC_1025 k007-0731 70 µM -0.323297035678071 0.39736841613423 no 2048 0.373235149376224 661 6256118
SGTC_42 0133-0086 60.653 µM -0.324216974913125 0.397085636016983 no 2049 0.372886885744639 716 162923 Model of phenazepam hydroxylation.
SGTC_466 geldanamycin 89.2 µM -0.324978499998285 0.396851591742522 no 2050 0.372598671902176 690 5288382 HSP90 inhibitor.
SGTC_579 4491-1009 110 µM -0.32539001096253 0.396725134956251 no 2051 0.372442957320814 699 1271041
SGTC_967 1306-0166 352 µM -0.326260416328906 0.396457696309818 no 2052 0.372113667115443 668 4437607
SGTC_464 bw-b 70c 158 µM -0.327748092524245 0.396000709357653 no 2053 0.371551068702968 724 5353454
SGTC_1719 st032227 49.2 µM -0.328440580548168 0.395788038385753 no 2054 0.371289282161081 668 3125804
SGTC_1692 fluoroquinolonic acid 71 µM -0.329117556079679 0.395580161462591 no 2055 0.371033417473241 716 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_2447 5741742 33.78 µM -0.329220028049958 0.395548698277215 no 2056 0.370994692886289 683 1776504
SGTC_1889 st059080 5.18 µM -0.330447682548336 0.395171809930823 no 2057 0.370530858788331 701 176925 Isolated from Daphnopsis sellowiana.
SGTC_3354 9151612 71.43 µM -0.330629602138808 0.395115969183847 no 2058 0.37046214166972 711 27261949
SGTC_1415 3966-0071 78.1 µM -0.330717903996623 0.395088865448403 no 2059 0.370428788592178 709 2893185
SGTC_2167 5876490 200 µM -0.331282457739466 0.394915591002895 no 2060 0.370215570301777 718 686534
SGTC_2888 9058547 12.99 µM -0.331303730264984 0.394909062384745 no 2061 0.37020753696269 681 16476514
SGTC_2860 9025725 38.96 µM -0.331626918687352 0.394809878272083 no 2062 0.370085495318003 717 40546248
SGTC_2600 tangeritin 87.95 µM -0.334808550045777 0.393833824224945 no 2063 0.36888475519764 707 68077 A bioactive flavone.
SGTC_3064 1327-0027 10 µM -0.335957458533855 0.39348152802983 no 2064 0.368451473465491 678 16000455 YPR107C YTH1
SGTC_430 0958-0115 16.4 µM -0.336462792049612 0.39332660239561 no 2065 0.368260952647056 692 6833180
SGTC_1169 aniline yellow 25.8 µM -0.336547484714816 0.393300638888934 no 2066 0.368229024990432 698 6051 A DNA damaging agent.
SGTC_2461 5755302 26.15 µM -0.336555220243553 0.393298267497638 no 2067 0.36822610887646 740 2788904
SGTC_2865 9030313 51.95 µM -0.337520718209802 0.393002317097103 no 2068 0.367862198313439 680 42562754
SGTC_1932 st074806 40.9 µM -0.338280734453814 0.392769395708919 no 2069 0.367575820260371 687 17251235
SGTC_671 0560-0003 407 µM -0.338942208628784 0.392566705652546 no 2070 0.3673266332827 695 3238678
SGTC_2648 atorvastatin 78.68 µM -0.339714946047951 0.392329959023058 no 2071 0.367035602570048 711 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_446 go6976 132 µM -0.34038551621155 0.392124546068241 no 2072 0.366783112300552 705 3501 A protein kinase C inhibitor.
SGTC_3301 9125354 19.7965 µM -0.342547201219519 0.391462571044238 no 2073 0.365969564283183 669 41905162
SGTC_1061 3448-9325 110 µM -0.346008095720451 0.390403392693785 no 2074 0.364668315300438 733 723482
SGTC_790 1575-0012 79.1 µM -0.347370062085825 0.389986796518863 no 2075 0.364156660831705 708 378741 YLR208W SEC13
SGTC_2971 9092186 9.93 µM -0.349191115895969 0.389429972835744 no 2076 0.363472917712672 660 25236400
SGTC_3239 9133757 49.47 µM -0.349412639750238 0.389362252938998 no 2077 0.363389772731759 713 17036923
SGTC_160 3453-0671 289.699 µM -0.352381990507547 0.388454846814695 no 2078 0.362275903208106 745 5322268
SGTC_2469 5655019 90.81 µM -0.354041007281685 0.387948131236022 no 2079 0.361654075793301 719 2788239
SGTC_390 dec-rvkr-cmk 16.7 µM -0.354312645809229 0.387865182487692 no 2080 0.361552295847211 692 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_549 1661-1316 519 µM -0.354982749035853 0.387660578674634 no 2081 0.361301257494802 728 2857282
SGTC_1441 4106-0040 13 µM -0.356343590615655 0.387245166533955 no 2082 0.360791634182119 686 2904180
SGTC_893 0958-0369 48.9 µM -0.358938254980458 0.386453474231486 no 2083 0.359820640311939 743 6819948
SGTC_3010 9080089 71.4286 µM -0.36137419224198 0.385710643104551 no 2084 0.358909868966605 714 17027233
SGTC_588 3970-1144 52.9 µM -0.36354281551087 0.385049680908211 no 2085 0.358099717666918 692 1888707
SGTC_2549 cedrol 20.94 µM -0.364250245063757 0.384834139651582 no 2086 0.357835575053667 698 6708665 A sedative which affects the nervous system.
SGTC_1743 st037606 46.3785 µM -0.365759202647518 0.38437450598445 no 2087 0.357272382541343 677 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_2215 7188065 200 µM -0.366965049131597 0.384007317797646 no 2088 0.356822544375592 711 940217
SGTC_2122 5258151 111.688 µM -0.367904279290102 0.383721388134251 no 2089 0.356472304640234 719 2173356
SGTC_487 nimodipine 119 µM -0.368778752564453 0.383455229295595 no 2090 0.356146321573982 706 4497 L-type voltage-gated calcium channels inhibitor
SGTC_2318 6029776 164 µM -0.368808174180849 0.383446275348199 no 2091 0.356135355713949 745 818325
SGTC_628 1636-0253 16 µM -0.369146451891989 0.383343330996972 no 2092 0.356009283291568 727 4456143
SGTC_2130 NSC 7 2.4545 µM -0.371695073801874 0.382568002051911 no 2093 0.355059946594531 711 21448
SGTC_2767 sibutramine 71.45 µM -0.372053493600955 0.382459003044845 no 2094 0.354926510703795 735 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_3116 9124943 49.47 µM -0.372942119075742 0.382188803425195 no 2095 0.354595761634477 677 41905195 YPL160W CDC60
SGTC_325 2810-4341 181 µM -0.373333161661051 0.38206991935461 no 2096 0.354450249121919 688 774970
SGTC_493 zm226600 134 µM -0.376138574131586 0.38121734948989 no 2097 0.353406939200546 744 5240098 A potassium channel opener. YCR052W RSC6
SGTC_1706 st031321 9.9705 µM -0.376221213094447 0.381192244077736 no 2098 0.353376223096309 703 6103185
SGTC_619 1652-1634 108 µM -0.377837236172204 0.380701402841771 no 2099 0.35277575508194 727 5400454
SGTC_129 0088-0017 176.636 µM -0.378921749706606 0.380372106738838 no 2100 0.352372986276115 736 182446
SGTC_2777 climbazole 1.536 µM -0.384928333404012 0.378549874053721 no 2101 0.350145256644023 717 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_2795 7780010 54.55 µM -0.387613145529063 0.377736245467396 no 2102 0.349151169670216 697 953673
SGTC_940 3232-1287 54.8 µM -0.38778765500761 0.377683379338911 no 2103 0.34908659096447 757 1585493 YIL048W NEO1
SGTC_2313 7726885 200 µM -0.388625510661381 0.377429590181424 no 2104 0.348776596295255 709 726423
SGTC_7 0192-1582 4.227 µM -0.38896298072366 0.377327384363916 no 2105 0.348651765674801 719 252616
SGTC_1648 st011736 69.8 µM -0.390288425206196 0.376926044885352 no 2106 0.348161640679421 706 2855514
SGTC_2198 6589944 200 µM -0.39130321483452 0.376618860329727 no 2107 0.347786561424076 710 5290268
SGTC_1138 3761-0006 1.03 µM -0.39275237881851 0.37618032280096 no 2108 0.347251190082583 725 12061087
SGTC_146 3448-8650 53.125 µM -0.394829329289163 0.375552086980447 no 2109 0.3464844240799 744 2891488 YIL048W NEO1
SGTC_2568 diosmetin 100 µM -0.395307204342607 0.375407585986531 no 2110 0.346308091601481 762 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_415 dibenzyl ketone 100 µM -0.396023534756852 0.37519101303737 no 2111 0.346043833194338 734 7593
SGTC_281 1672-3440 14.9 µM -0.400140515285789 0.373947063555253 no 2112 0.344526512260072 723 6833000
SGTC_3181 9108277 49.47 µM -0.400665155099032 0.373788637105741 no 2113 0.344333334230049 742 17097298
SGTC_983 1491-0821 12.2 µM -0.402050622568464 0.373370367508346 no 2114 0.343823385492037 700 46495113
SGTC_3288 9119690 36.221 µM -0.403132168150653 0.37304395490003 no 2115 0.343425498549146 746 17595618 YKL019W RAM2
SGTC_681 1642-0006 26.6 µM -0.40338432837465 0.372967865531646 no 2116 0.343332756910119 734 4446530
SGTC_2114 5491910 81.25 µM -0.404482007913859 0.372636698409645 no 2117 0.342929152932635 736 2849228
SGTC_2882 9058044 58.44 µM -0.40516215591105 0.372431546705672 no 2118 0.342679160309718 724 18076804
SGTC_2433 5607874 27.82 µM -0.406549287856569 0.372013261052216 no 2119 0.342169524938164 720 2252428
SGTC_515 4092-1064 102 µM -0.406562462022956 0.372009289143281 no 2120 0.34216468609611 772 717353
SGTC_1569 carminic acid 40.6 µM -0.407377988617029 0.371763440736541 no 2121 0.341865195477424 707 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2719 novobiocin 32.65 µM -0.407573987306958 0.371704362818594 no 2122 0.341793232549228 734 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_959 1222-0044 107 µM -0.408191215112374 0.371518337780376 no 2123 0.341566648599381 735 6083612
SGTC_1198 1612-1005 86.7 µM -0.408639804076629 0.371383157284994 no 2124 0.341402007678242 715 6998509
SGTC_150 3970-0969 77.2 µM -0.410726522558517 0.370754541760953 no 2125 0.340636538328051 740 6615640
SGTC_1798 st045719 60.953 µM -0.411193187752126 0.370614007876864 no 2126 0.340465441519471 723 3980186
SGTC_1782 st039423 80.636 µM -0.41161704275786 0.37048638102516 no 2127 0.34031006896576 735 2068169
SGTC_1861 st057647 17.4 µM -0.413034216787039 0.370059759756054 no 2128 0.339790772350867 744 688668
SGTC_1425 4048-4433 7.33 µM -0.41375248770939 0.369843594910183 no 2129 0.339527691541696 753 23734946
SGTC_2017 5132927 60.65 µM -0.417019977921314 0.368860758147571 no 2130 0.338331897531498 734 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_1401 3807-4679 7.6 µM -0.418582987225624 0.368390919175394 no 2131 0.337760462596855 733 3291456
SGTC_1335 1486-0900 202 µM -0.420033185520385 0.367955166988981 no 2132 0.337230605500857 697 X1335
SGTC_461 N-acetylfarnesylcysteine 136 µM -0.420476089237486 0.367822118153452 no 2133 0.337068846612434 743 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_2018 5133068 143 µM -0.421102007207476 0.367634118649975 no 2134 0.336840297969745 760 785362
SGTC_3186 9110464 49.47 µM -0.421435105582745 0.367534082796638 no 2135 0.336718694472146 727 17018021
SGTC_2048 5246248 200 µM -0.421726809484479 0.36744648588193 no 2136 0.336612216783743 713 677046
SGTC_427 1354-0053 47.3 µM -0.421728835956115 0.367445877368891 no 2137 0.336611477127355 754 6813657
SGTC_1822 st052468 42 µM -0.421896483689231 0.367395536918321 no 2138 0.336550288370744 717 2873678
SGTC_1703 st026983 48.3 µM -0.421940407762045 0.367382347986864 no 2139 0.336534257498077 733 1104023
SGTC_2408 sulbentine 18.36 µM -0.422329285042125 0.367265587958488 no 2140 0.336392342770697 734 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_1372 2752-0194 270 µM -0.424129590313919 0.366725208115319 no 2141 0.335735653271751 736 823334
SGTC_1160 4092-0570 10.5 µM -0.424665637076431 0.366564359219907 no 2142 0.335540218594774 735 4994975
SGTC_3154 9100113 49.47 µM -0.428442544655288 0.365431706957166 no 2143 0.334164477782878 736 25237525
SGTC_411 enrofloxacin 100 µM -0.430994726863786 0.364666999309745 no 2144 0.333236102330953 731 71188 A bacterial gyrase inhibitor.
SGTC_1992 st073643 23.3 µM -0.432156068636642 0.364319205677022 no 2145 0.332813993119499 744 3161292
SGTC_2157 5649910 96.377 µM -0.433729626082764 0.363848141697809 no 2146 0.332242395173423 745 2858091
SGTC_703 3875-0075 71.8 µM -0.436144347661811 0.363125665008115 no 2147 0.331366001446614 759 2850814
SGTC_1330 1469-0054 61.8 µM -0.437943961015953 0.362587543063813 no 2148 0.330713453460282 740 7102664
SGTC_3199 9111318 49.47 µM -0.438975088496125 0.362279336628308 no 2149 0.330339793503611 729 8548020
SGTC_2188 6126565 140.678 µM -0.439290871221931 0.362184966270341 no 2150 0.330225393972876 732 874518
SGTC_3049 9092223 49.47 µM -0.440193616308529 0.361915230861759 no 2151 0.329898441428424 754 8623917
SGTC_3166 9102297 49.47 µM -0.440889447172889 0.361707367110396 no 2152 0.329646516875439 745 25237072
SGTC_1060 3448-7350 82 µM -0.443313273746214 0.360983622612002 no 2153 0.328769578026525 754 570178
SGTC_2822 7994718 71.43 µM -0.444657898612882 0.360582337589751 no 2154 0.328283499518725 767 1018011
SGTC_3258 9138477 49.47 µM -0.446771854585678 0.359951766620578 no 2155 0.327519897464757 734 4970355
SGTC_3197 9113331 49.47 µM -0.447700569155348 0.359674861108503 no 2156 0.32718465542746 734 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_1443 4112-3303 14 µM -0.448516613347115 0.359431610177361 no 2157 0.326890199511745 743 704433
SGTC_1976 st070609 63.5 µM -0.449520682929035 0.359132389763452 no 2158 0.326528045646866 730 682556
SGTC_271 rotenone 740 µM -0.450100431745644 0.358959659512353 no 2159 0.326319012753982 768 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.45125835146146 0.358614755468998 no 2160 0.32590167920031 756 7104
SGTC_1673 st016611 27.3 µM -0.453023007830399 0.358089347448495 no 2161 0.3252660870878 769 5226799
SGTC_2918 7977171 22.06 µM -0.454583316128668 0.357625005674068 no 2162 0.324704519891899 751 2236483
SGTC_443 clozapine 122 µM -0.455253585214281 0.35742560080253 no 2163 0.324463406987771 754 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_1315 1237-0019 3.69 µM -0.456288145181973 0.35711789590684 no 2164 0.324091393781643 737 825140
SGTC_2727 riluzole 51.77 µM -0.458213615354525 0.356545458764666 no 2165 0.323399489501025 739 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_1903 st060211 78.3 µM -0.458657486632804 0.35641354278456 no 2166 0.32324007392316 736 688960
SGTC_2546 rhodinyl acetate 100 µM -0.46118610573234 0.35566237988123 no 2167 0.322332544625367 736 6708682
SGTC_2667 digitoxin 100 µM -0.461505134660475 0.355567647457107 no 2168 0.322218119194126 725 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_82 0054-0107 293.755 µM -0.46226243626622 0.355342810111779 no 2169 0.321946566901052 751 3104697
SGTC_2524 avocatin b 10.57 µM -0.462541672058559 0.355259919732437 no 2170 0.321846462846239 748 6710748
SGTC_1376 2910-0861 41.3 µM -0.463098545507398 0.355094633824275 no 2171 0.321646866263568 757 1112859
SGTC_2440 5628896 157.78 µM -0.463587011709933 0.354949674350874 no 2172 0.321471830822008 761 5522048
SGTC_2854 9024559 71.43 µM -0.46438582594804 0.35471265981775 no 2173 0.321185671658079 767 3163529
SGTC_300 r073-0011 5.04 µM -0.467487333713964 0.353792951552469 no 2174 0.320075626081854 758 2735780
SGTC_1646 st011709 75.6 µM -0.467549101698018 0.353774643772221 no 2175 0.320053535309129 748 5757843
SGTC_867 0518-0118 155 µM -0.468413188143783 0.353518567521153 no 2176 0.319744569357085 760 6848158
SGTC_944 3370-0224 231 µM -0.468483437268324 0.353497751760894 no 2177 0.319719456312848 733 4580514
SGTC_648 0375-0473 33.3 µM -0.469889866683793 0.353081100081781 no 2178 0.319216852210428 748 1713139
SGTC_1263 0774-1208 64.8 µM -0.470055395923243 0.353032073973631 no 2179 0.319157720213479 789 906585
SGTC_2295 7971645 200 µM -0.471108641439185 0.352720183070595 no 2180 0.318781577226299 740 2978226 YKL099C UTP11
SGTC_433 pimozide 108 µM -0.471928172231852 0.35247756907154 no 2181 0.318489029267932 740 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_704 1310-0270 142 µM -0.471969561714285 0.352465317714919 no 2182 0.31847425746138 779 5718033
SGTC_1431 4049-0260 9.09 µM -0.47221947385653 0.352391346551825 no 2183 0.318385070552 762 3854841
SGTC_2355 9061122 103.12 µM -0.474973175748495 0.351576652200491 no 2184 0.31740304639266 757 5302957
SGTC_939 1165-0479 45.3 µM -0.476628389653956 0.351087277723919 no 2185 0.316813381903007 752 1377347
SGTC_1875 nocodazole 6 µM -0.477152533507453 0.35093236269622 no 2186 0.316626754267445 748 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_880 0833-0487 87.2 µM -0.480175377500555 0.350039420449963 no 2187 0.315551346734703 739 76075
SGTC_616 4092-0450 108 µM -0.480336059988556 0.349991978304578 no 2188 0.3154942258971 759 787165
SGTC_1927 st060202 13.8 µM -0.481239791297816 0.349725191668911 no 2189 0.315173041624023 718 688887
SGTC_3106 9121286 49.47 µM -0.481519167097663 0.349642733345762 no 2190 0.31507378028192 737 15943471
SGTC_508 roscovitine 141 µM -0.48217976355615 0.34944778520775 no 2191 0.314839125563328 754 160355 A CDKinase inhibitor.
SGTC_3129 9127257 49.47 µM -0.482411245028777 0.349379482271111 no 2192 0.314756917217569 782 837894
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.482904628786962 0.349233916446587 no 2193 0.314581727514841 732 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_1882 5615643 20 µM -0.484312748322694 0.348818592932099 no 2194 0.314081964931503 739 2253075
SGTC_1298 1079-1278 263 µM -0.484785516043768 0.348679191124294 no 2195 0.313914248990524 769 2840950
SGTC_1041 0206-0046 107 µM -0.485052089698091 0.348600597366503 no 2196 0.313819698032859 767 50494
SGTC_518 1021-0119 62.6 µM -0.487476018382514 0.347886250399288 no 2197 0.312960516834415 771 1097762
SGTC_2208 7283366 200 µM -0.487651218062974 0.347834638835786 no 2198 0.312898455157498 771 898663
SGTC_1146 3579-1023 7 µM -0.488676139372659 0.347532766770893 no 2199 0.312535499503164 768 X1146
SGTC_947 3447-0010 211 µM -0.489105791079958 0.347406249361573 no 2200 0.312383400876441 761 748350
SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.490013295759695 0.347139076840547 no 2201 0.312062245228459 725 3256 An antibiotic and ribosome inhibitor.
SGTC_1475 4092-1048 11.7 µM -0.490667607226223 0.346946492395296 no 2202 0.31183078037047 768 2881759
SGTC_2286 7945697 125 µM -0.491603169327149 0.346671195719669 no 2203 0.311499951253073 755 1245733
SGTC_2711 st079103 59.1 µM -0.492290677122514 0.346468942608531 no 2204 0.311256934901276 753 54693780
SGTC_1844 rapamycin 4 nM -0.493386023000267 0.34614680088737 no 2205 0.310869928175645 765 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_1403 3909-7815 62.9 µM -0.493888509294077 0.345999056664597 no 2206 0.310692460062747 748 6615483
SGTC_598 3937-0236 20.2 µM -0.494683256736975 0.345765427820546 no 2207 0.31041186107446 772 1379313
SGTC_2053 5265679 138 µM -0.495019857448238 0.345666496302345 no 2208 0.310293051757875 755 764595
SGTC_2121 5257820 149.641 µM -0.496389903898966 0.345263929860399 no 2209 0.309809673414163 756 791256
SGTC_38 0929-0051 58.268 µM -0.496838467648348 0.345132164517461 no 2210 0.309651483002236 764 1379719
SGTC_355 1311-2252 105 µM -0.497335978474728 0.344986042957178 no 2211 0.309476072154576 773 5338538
SGTC_2801 7907800 81.82 µM -0.498398591928916 0.344674025194521 no 2212 0.30910156451952 787 6620925
SGTC_3261 9137475 49.47 µM -0.500410122951132 0.344083663853927 no 2213 0.308393163462639 727 17027690
SGTC_195 4234-0266 16.654 µM -0.50096130349579 0.343921964906798 no 2214 0.30819917847198 749 2303354
SGTC_2820 7989630 71.43 µM -0.501335990442686 0.343812059895782 no 2215 0.308067340016856 739 2984098
SGTC_1017 4239-0030 168 µM -0.501491265757965 0.343766517646954 no 2216 0.308012711642658 739 1149593
SGTC_2333 9017922 200 µM -0.50348320219693 0.343182483997394 no 2217 0.307312293738712 751 3163164
SGTC_2166 5933061 31.504 µM -0.504662442556598 0.342836908294658 no 2218 0.306897972146273 744 2877375
SGTC_2317 5986382 200 µM -0.505159146961808 0.342691388685893 no 2219 0.306723530706813 786 877883
SGTC_215 1287-0124 461.5 µM -0.505435607773116 0.342610404005047 no 2220 0.306626457264982 764 5560863
SGTC_1178 0988-0033 191 µM -0.505511820110605 0.342588080116911 no 2221 0.306599699278529 742 5392207
SGTC_539 4859-0462 2.54 µM -0.50630854799359 0.342354737917105 no 2222 0.306320031586595 744 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_1769 st044406 64.4 µM -0.506389676105591 0.34233098084201 no 2223 0.306291560294355 773 670903
SGTC_2732 terfenadine 20 µM -0.508872307088034 0.341604283980571 no 2224 0.305420866097243 770 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_177 1327-0068 8.361 µM -0.509033945597595 0.341556990700057 no 2225 0.30536421523301 759 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_3320 9137005 35.139 µM -0.509165049320656 0.341518633319324 no 2226 0.305318269586231 765 4908713
SGTC_1686 st019653 115.5 µM -0.509672565902295 0.341370163216795 no 2227 0.30514043797795 785 97252
SGTC_2415 st077333 57.7 µM -0.51036827940616 0.341166677434128 no 2228 0.304896737729695 788 2766255
SGTC_334 1502-1024 68.5 µM -0.511306814434807 0.340892243171013 no 2229 0.304568117055568 772 3296216
SGTC_2176 5809774 33.9695 µM -0.511787573306408 0.340751698478004 no 2230 0.304399844161352 752 2870539
SGTC_2345 9052315 157.45 µM -0.514742948764656 0.33988821241093 no 2231 0.30336632846658 751 6469265
SGTC_2656 pseudo-anisatin 100 µM -0.514821266292756 0.339865341404197 no 2232 0.303338961612016 784 6708809 A neurotoxin.
SGTC_640 3381-0960 37.1 µM -0.517967081918055 0.338947159449922 no 2233 0.302240618382164 768 1745025
SGTC_870 0573-2213 57.6 µM -0.519191369724096 0.33859007970997 no 2234 0.301813648368352 762 3916321
SGTC_2072 5231554 129 µM -0.520398700566358 0.338238087736388 no 2235 0.301392857790693 770 789545
SGTC_2942 9052777 62.25 µM -0.521900965605049 0.337800306356781 no 2236 0.300869642985055 798 6469503
SGTC_107 0358-0022 2.6945 µM -0.523504568324492 0.337333235762957 no 2237 0.300311586394375 795 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_1253 0550-0034 176 µM -0.525880081785369 0.336641796560536 no 2238 0.299485764467345 740 5969915
SGTC_2079 5212404 121 µM -0.527171885665035 0.336266023526596 no 2239 0.299037115178938 765 758462
SGTC_996 3970-0799 1.8 µM -0.527615024928733 0.336137156326461 no 2240 0.298883281252897 755 6615648 YGL040C HEM2
SGTC_84 0443-0269 128.823 µM -0.527828440459661 0.336075100849996 no 2241 0.298809207780819 772 6150058
SGTC_83 0170-0301 39.027 µM -0.528166887748418 0.335976698673428 no 2242 0.298691754686469 763 3089716
SGTC_2729 fluphenazine 10.66 µM -0.529272177476958 0.335655418498733 no 2243 0.298308326618727 783 3372 An atypical antipsychotic.
SGTC_2740 felodipine 17.08 µM -0.532337653575326 0.334764990060308 no 2244 0.297246078905117 742 3333 L-type calcium channel blocker
SGTC_2191 5911152 200 µM -0.533834891865705 0.334330424543182 no 2245 0.296727885540581 757 2875902
SGTC_3041 9091929 49.47 µM -0.533886744155264 0.334315378662433 no 2246 0.296709946903706 779 25236887
SGTC_1184 1269-1718 139 µM -0.53491802067057 0.334016190426742 no 2247 0.296353273284713 762 5403821
SGTC_620 0109-0052 432 µM -0.535279986213396 0.333911203980415 no 2248 0.296228131795248 790 493037
SGTC_46 0329-0187a 2.197 µM -0.536234772055481 0.333634335106828 no 2249 0.295898152298562 786 46494817
SGTC_2446 5162541 200 µM -0.537214738336844 0.333350258595353 no 2250 0.295559645941867 766 1549321
SGTC_1149 3909-7961 23.3 µM -0.537688928187105 0.333212832857655 no 2251 0.295395912132902 743 735261
SGTC_702 1488-0190 94 µM -0.537834326168286 0.33317069931473 no 2252 0.295345715780499 769 949357
SGTC_2462 5162487 171.77 µM -0.539302417281698 0.332745392735436 no 2253 0.294839100585531 772 2259986
SGTC_561 1550-0330 72.9 µM -0.539706280803012 0.332628431022796 no 2254 0.294699803913057 775 6812934
SGTC_2478 5763493 32.33 µM -0.540160072639371 0.33249702915517 no 2255 0.294543322673819 768 1365576 YLR208W SEC13
SGTC_1140 3229-1848 2.98 µM -0.540365952546005 0.332437420491666 no 2256 0.294472341660343 786 2849525
SGTC_815 1582-0027 36.9 µM -0.541062788674818 0.332235696118375 no 2257 0.294232152757002 774 3128206
SGTC_1308 1187-1617 41.4 µM -0.542097903566224 0.331936134467392 no 2258 0.293875531431723 779 2882570
SGTC_564 3555-0129 330 µM -0.542387002234339 0.331852488658536 no 2259 0.293775965897031 771 563260
SGTC_2598 perillyl alcohol 100 µM -0.543381581180492 0.331564788099259 no 2260 0.293433552339684 757 10819 An apoptosis inducer.
SGTC_1324 1418-0026 34.4 µM -0.549644652381558 0.329755365917542 no 2261 0.291281562977348 788 1372513
SGTC_1994 st072947 40.9 µM -0.551268479879449 0.329286884265886 no 2262 0.290724821237757 805 5286565 YDL195W SEC31
SGTC_521 r062-0005 13.8 µM -0.554326438061141 0.328405377087625 no 2263 0.289677729954872 771 2832033
SGTC_2373 9071805 200 µM -0.554966227119391 0.328221067840329 no 2264 0.289458880580834 806 10149009
SGTC_1310 1188-0297 994 nM -0.556890249425277 0.32766705111912 no 2265 0.28880120847888 772 1588352
SGTC_1633 st005664 67.9 µM -0.561120606941804 0.326450266458683 no 2266 0.287357660541741 790 2063822
SGTC_982 1491-0518 27.5 µM -0.561910893642754 0.326223159077375 no 2267 0.287088365585019 781 3091256
SGTC_1675 st018485 24.5 µM -0.562073899219018 0.326176323621643 no 2268 0.287032835322118 798 3323024
SGTC_2432 5630864 12.22 µM -0.562575887153332 0.326032107535909 no 2269 0.286861857662742 797 5714970
SGTC_1615 st002656 86.5 µM -0.563349481634204 0.325809912568166 no 2270 0.286598465043578 773 1584458
SGTC_94 0334-0113 514.748 µM -0.564691087341319 0.325424717788792 no 2271 0.286141948728238 787 6795178
SGTC_2032 5185112 25.99 µM -0.565159389760952 0.325290305126878 no 2272 0.285982677994678 762 5718189
SGTC_1733 st037357 54.9 µM -0.565828722270919 0.325098232048657 no 2273 0.28575510964022 794 1272339 YGL099W LSG1
SGTC_1020 4335-0961 93.3 µM -0.56684751612134 0.324805966007308 no 2274 0.285408892305886 794 669075
SGTC_288 1315-0019 35.1 µM -0.568096184001483 0.324447902008383 no 2275 0.28498482938667 789 6811474
SGTC_2636 apigenin dimethyl ether 100 µM -0.56857146520858 0.324311654503535 no 2276 0.284823497050683 807 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_174 3553-0389 74.3 µM -0.569463165006468 0.324056096939022 no 2277 0.284520930692767 760 738071
SGTC_3147 9097027 49.47 µM -0.569768059037606 0.323968734550547 no 2278 0.284417511064889 795 25236841
SGTC_250 brefeldin a 552.239 µM -0.569810825259534 0.323956481365631 no 2279 0.284403006258839 775 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_2617 dihydrotanshinone i 20.83 µM -0.570982867089134 0.323620747515581 no 2280 0.284005628322953 789 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.571244443264164 0.323545838048059 no 2281 0.283916977829155 785 616764
SGTC_362 0310-0100 9.03 µM -0.573270998369918 0.322965721237254 no 2282 0.283230609408117 771 790235
SGTC_2506 ethyl hematommate 54.16 µM -0.573682499152909 0.322847978536624 no 2283 0.283091336608874 783 3940691 An allergen.
SGTC_1896 st058441 89 µM -0.574702008871879 0.322556342772305 no 2284 0.28274642430656 760 688759
SGTC_1361 1608-0041 5.61 µM -0.574735568118173 0.322546744839484 no 2285 0.282735074246373 791 X1361
SGTC_56 0957-0365 83.25 µM -0.576630255631769 0.322005056836178 no 2286 0.28209462801961 769 6752360
SGTC_2199 6590217 200 µM -0.577328258497978 0.321805594184105 no 2287 0.281858863824848 765 703109
SGTC_277 nystatin 15.5 µM -0.579163573107876 0.321281376209362 no 2288 0.281239403658618 800 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_877 0771-0151 33.1 µM -0.580630644316629 0.320862594854134 no 2289 0.280744707181834 788 6166523
SGTC_2569 tetrandrine 100 µM -0.581045968180603 0.320744080347348 no 2290 0.28060473642738 765 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1092 toremifene 6.32 µM -0.582362929215869 0.320368400522032 no 2291 0.280161123010045 819 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_3313 9133968 57.047 µM -0.584474133688763 0.319766536735322 no 2292 0.279450681475273 789 1494643
SGTC_486 niguldipine 82 µM -0.586254543367296 0.319259344687091 no 2293 0.278852236580312 790 1236 A calcium channel blocker.
SGTC_2287 7945887 168.79 µM -0.58791964846852 0.318785305774227 no 2294 0.278293113691273 783 1245853
SGTC_3332 9141069 11.198 µM -0.588089877627367 0.318736859904549 no 2295 0.278235983530445 796 17332883
SGTC_2967 9089538 49.85 µM -0.58848290001414 0.318625020680705 no 2296 0.278104104166 816 728216
SGTC_142 0335-0849 62.6745 µM -0.58903914795585 0.318466761910647 no 2297 0.277917506306019 788 3889043 YPR107C YTH1
SGTC_654 1124-0271 80.9 µM -0.589596997357968 0.318308080766727 no 2298 0.277730432616612 797 5403748
SGTC_2347 9049783 174.81 µM -0.590656522328415 0.318006789007927 no 2299 0.27737529243634 828 6467988 YPL169C MEX67
SGTC_2528 xanthyletin 44.79 µM -0.590865316824978 0.317947429369171 no 2300 0.277305333200185 805 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_2290 7904846 200 µM -0.591463826604523 0.317777300787398 no 2301 0.277104842763833 777 2962154
SGTC_1653 st012112 65 µM -0.59310865210652 0.317309951338279 no 2302 0.276554220251542 808 720429
SGTC_218 alverine citrate 93.75 µM -0.595352918534484 0.316672750549117 no 2303 0.275803794880939 795 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_482 fipronil 114 µM -0.595608421507828 0.316600241590995 no 2304 0.275718424697669 792 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_911 3456-4043 236 µM -0.599561211355047 0.315479382192816 no 2305 0.274399352166305 795 914281
SGTC_2539 epi(13)torulosol 80 µM -0.601112119922552 0.315040066664415 no 2306 0.273882655720098 799 6708597
SGTC_95 0471-0001 561.058 µM -0.601789933363651 0.314848149053877 no 2307 0.273656988401014 781 4015405
SGTC_469 w7 172 µM -0.603050252761438 0.314491432327823 no 2308 0.273237629592446 791 45115570 A P450 inhibitor.
SGTC_1024 4507-0395 26 µM -0.603090909076056 0.314479927976678 no 2309 0.273224106908481 766 4201836
SGTC_322 k048-0136 19.3 µM -0.603423464437471 0.314385832909659 no 2310 0.27311350822408 796 6823282
SGTC_87 0100-0052 35.5 µM -0.603803770523803 0.314278241766252 no 2311 0.272987056174425 815 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_1231 0242-0792 125 µM -0.604179664918316 0.314171914223635 no 2312 0.272862099546087 801 3707635
SGTC_109 0132-0036 33.701 µM -0.604459540008357 0.31409275724081 no 2313 0.272769080546362 764 67274 A color developer.
SGTC_505 gw-5074 63.9 µM -0.60452295435321 0.314074822970018 no 2314 0.272748006405695 800 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_1793 st048256 72.231 µM -0.607283241222428 0.313294609610732 no 2315 0.271831479086187 800 672022
SGTC_1344 1488-0097 29.1 µM -0.609263771189846 0.312735313889779 no 2316 0.271174808315488 821 747966
SGTC_2395 5646831 180.19 µM -0.610078365658761 0.312505399833634 no 2317 0.270904948546803 819 6808628
SGTC_862 0452-0056 10.2 µM -0.610223116705777 0.312464552412076 no 2318 0.270857009283948 800 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_3019 9081971 49.47 µM -0.610735511355256 0.312319977844581 no 2319 0.270687346288233 788 16451803
SGTC_2670 beta-carotene 100 µM -0.611115780536531 0.312212701775767 no 2320 0.27056146670463 773 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_1181 1222-0449 220 µM -0.61420470153136 0.311341890336992 no 2321 0.269540033472766 813 658318
SGTC_2464 5717415 7.67 µM -0.615823407900439 0.310885974420184 no 2322 0.269005538231761 787 5285744
SGTC_2811 7967822 32.47 µM -0.618496940483519 0.31013359754367 no 2323 0.268123906982503 791 2232244
SGTC_504 lovastatin 124 µM -0.62006265125428 0.309693348788562 no 2324 0.267608270081513 821 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_528 3492-0019 172 µM -0.620628124329337 0.309534415310853 no 2325 0.267422165284414 811 2869262
SGTC_634 1611-4317 11.2 µM -0.620654914999189 0.309526886332051 no 2326 0.267413349734429 815 2843522
SGTC_541 4513-1321 94 µM -0.622291088491197 0.309067224307672 no 2327 0.266875239944209 798 747515
SGTC_3012 9080433 71.4286 µM -0.62290639133893 0.308894440106733 no 2328 0.266673018886608 819 17688859
SGTC_1671 st016596 74.5 µM -0.625638297079008 0.308127800219596 no 2329 0.265776106651063 813 2829167
SGTC_148 3253-0744 288.01 µM -0.626439173903511 0.307903212883589 no 2330 0.265513460850259 793 6893655
SGTC_864 0469-0573 172 µM -0.626650412492175 0.307843987905234 no 2331 0.265444207569235 813 689425
SGTC_2281 7943571 200 µM -0.627570696046388 0.30758602636216 no 2332 0.265142605210934 810 1244024
SGTC_2162 5663267 200 µM -0.627646289378958 0.307564841278736 no 2333 0.265117838923707 819 6456493
SGTC_1705 st027868 56.3335 µM -0.62777783080953 0.307527978232478 no 2334 0.265074745426255 813 292948
SGTC_1412 3909-8563 178 µM -0.629883789789763 0.306938071134719 no 2335 0.264385309699289 825 23767530
SGTC_1078 idebenone 36.1 µM -0.630411525873066 0.30679032345297 no 2336 0.264212685885349 826 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_2205 7238770 200 µM -0.6311908060653 0.306572209590332 no 2337 0.26395788636042 804 279867
SGTC_1591 genipin 88.4 µM -0.631301416609229 0.306541256194028 no 2338 0.263921730427364 835 442424 A DNA cross-linking agent.
SGTC_1210 3013-0140 750 nM -0.632079999160686 0.306323415710722 no 2339 0.263667301915232 803 905973
SGTC_1012 4112-3522 18 µM -0.63227623749763 0.306268520763053 no 2340 0.263603194066311 793 3112398
SGTC_3031 9088762 49.47 µM -0.632767545764841 0.306131103178058 no 2341 0.263442726594319 811 205253
SGTC_2893 9048488 25.97 µM -0.632884453393967 0.306098408448918 no 2342 0.263404550434896 812 6467338
SGTC_816 0325-0417 81.3 µM -0.634352825886618 0.305687890702798 no 2343 0.262925294367828 811 68101
SGTC_1042 0350-0096 82 µM -0.635517694657575 0.305362398086467 no 2344 0.262545414996906 809 3122515
SGTC_235 0330-0087 5 mM -0.637491626569601 0.304811184848992 no 2345 0.261902331220444 804 46494818 YHR062C RPP1
SGTC_1236 0330-0013 258 µM -0.638559833783411 0.304513076441449 no 2346 0.261554659033757 815 4617066
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.640536135824418 0.303961885096607 no 2347 0.260912052072503 819 688788
SGTC_988 1497-1057 103 µM -0.64234416940905 0.303458013899357 no 2348 0.260324870691741 826 3533044
SGTC_3211 9128781 49.47 µM -0.643970822046969 0.303005009912544 no 2349 0.259797177411697 803 17194361
SGTC_1304 1165-0502 251 µM -0.64598475247917 0.302444573184031 no 2350 0.259144615038557 810 767425
SGTC_1748 st037455 53.6035 µM -0.649223043974597 0.301544397181979 no 2351 0.258097109476015 825 580690
SGTC_3201 9113999 49.47 µM -0.65136033856381 0.300950935989542 no 2352 0.25740695336996 814 16649224
SGTC_1860 st056228 74.6 µM -0.651951401167691 0.30078690902677 no 2353 0.257216262103824 843 688679
SGTC_1393 3470-5649 58.2 µM -0.65303873871493 0.300485265214558 no 2354 0.256865652312192 801 4108395
SGTC_2999 9069765 71.4286 µM -0.658853033101329 0.298874616352341 no 2355 0.254995074082954 799 2097066
SGTC_2673 kobusone 100 µM -0.660848777064942 0.298322670253542 no 2356 0.254354649134146 838 6710676 An epoxy ketone and protein crosslinker.
SGTC_633 0437-0093 97.7 µM -0.661028416858222 0.298273011560677 no 2357 0.254297044947549 826 2831118
SGTC_1516 st013856 110 µM -0.661234097086736 0.298216159007109 no 2358 0.254231098905015 811 5281404 A mutagen and neurotoxin.
SGTC_3136 9095672 49.47 µM -0.66310560337389 0.297699078481396 no 2359 0.253631461098984 809 17217380
SGTC_201 4262-0159 12.803 µM -0.663454065438658 0.29760284670773 no 2360 0.253519894605643 821 1341029
SGTC_2146 5545642 200 µM -0.665121609770509 0.297142531991933 no 2361 0.252986356977106 814 825326
SGTC_40 0327-0103 19.753 µM -0.665812600067217 0.296951884070694 no 2362 0.252765445071888 817 409036
SGTC_846 0335-0850 148 µM -0.668616508537097 0.296178845614049 no 2363 0.251870069503951 820 6819598
SGTC_1063 disulfiram 1.84 µM -0.669252320424261 0.296003680568122 no 2364 0.251667268022487 839 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1249 0481-0015 10.2 µM -0.670743805210383 0.29559296589663 no 2365 0.251191875836946 852 4227577
SGTC_35 0133-0054 64.071 µM -0.672871329131441 0.295007557046912 no 2366 0.250514576881636 826 99677
SGTC_887 0885-0007 9.62 µM -0.6738170252291 0.294747511174988 no 2367 0.250213824725639 823 5719458
SGTC_1075 aripiprazole 15.2 µM -0.67466367604769 0.294514790315255 no 2368 0.249944733680996 817 60795 An atypical antipschotic. YIL048W NEO1
SGTC_3227 9130768 49.47 µM -0.676881996571175 0.293905437965921 no 2369 0.249240413848967 836 17720899
SGTC_205 1486-1330 71.903 µM -0.677041369440341 0.293861682156247 no 2370 0.249189853408985 825 4118834
SGTC_2838 9002687 71.43 µM -0.677149241722916 0.293832067538971 no 2371 0.249155634431113 825 6457060
SGTC_3237 9133362 49.47 µM -0.678768428651901 0.293387711544881 no 2372 0.248642300421992 838 43845137
SGTC_33 0986-0033 35.816 µM -0.679863252047819 0.293087433999407 no 2373 0.2482955258982 797 2848082
SGTC_2386 9075165 157.42 µM -0.682760751345147 0.29229342462318 no 2374 0.247379017170368 826 16452277
SGTC_2889 9059656 51.95 µM -0.683915442953625 0.291977280472452 no 2375 0.247014280901515 844 3949838
SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.685067437098028 0.291662033613227 no 2376 0.246650683603915 846 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_3334 9142812 21.919 µM -0.685095340488518 0.291654399730162 no 2377 0.24664188017393 824 45283678
SGTC_103 0844-0104 51.839 µM -0.685662293531181 0.291499311399499 no 2378 0.246463044764685 836 5375804
SGTC_2300 7976697 71.57 µM -0.685885467250397 0.291438273439662 no 2379 0.246392667586556 816 2236109
SGTC_2382 9035899 200 µM -0.687155668865469 0.291090987186151 no 2380 0.245992318411103 838 6462679
SGTC_358 0075-0058 9.45 µM -0.687169966123995 0.291087079268147 no 2381 0.24598781410926 875 1069125
SGTC_997 3996-0078 137 µM -0.689481913000336 0.290455469623575 no 2382 0.245260025741555 818 735687
SGTC_2706 st078239 82.5 µM -0.689725609495142 0.290388930633637 no 2383 0.245183378902251 835 15434492
SGTC_2321 7390090 138.78 µM -0.689806724529034 0.290366784535035 no 2384 0.245157869652984 839 649046
SGTC_85 0868-0259 160.055 µM -0.690328185443545 0.290224433699851 no 2385 0.24499391346625 811 83173
SGTC_1087 pterostilbene 9.05 µM -0.69180227819052 0.289822205914994 no 2386 0.244530752878883 847 5281727 Similar to reservatol, lowers cholesterol.
SGTC_3164 9100705 49.47 µM -0.693999138056356 0.289223246293605 no 2387 0.243841374733529 806 17174235
SGTC_1925 st057770 10.1 µM -0.69441657264958 0.289109501275138 no 2388 0.24371050177651 821 5989122
SGTC_200 k038-0079 37.545 µM -0.698139555862461 0.288095972722159 no 2389 0.242544961328027 851 3436683
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.699038481639286 0.287851504660804 no 2390 0.242263991129082 831 6708514
SGTC_113 0099-0221 2.5 µM -0.699289238204589 0.287783327444581 no 2391 0.24218564559065 832 89219
SGTC_593 1203-0218 61.7 µM -0.699404071313615 0.287752108468975 no 2392 0.242149772105651 835 3666956
SGTC_901 1112-0062 60.1 µM -0.701929926818146 0.287065824568767 no 2393 0.241361432232732 837 1908457
SGTC_691 1548-0686 185 µM -0.704111089409892 0.286473819326291 no 2394 0.240681797319477 839 46495133
SGTC_891 0929-0073 133 µM -0.704686123923372 0.28631784156652 no 2395 0.240502794273244 845 5603632
SGTC_2306 7482397 179.52 µM -0.706295884471189 0.285881409554439 no 2396 0.240002076130762 867 891448
SGTC_2093 5331342 194.4 µM -0.707574892192987 0.285534875606065 no 2397 0.23960464468728 823 33839
SGTC_655 k060-0012 42 µM -0.707678271304325 0.28550687483838 no 2398 0.239572536960828 846 5994525
SGTC_2943 9068529 45.32 µM -0.708621806183999 0.285251373958959 no 2399 0.239279600261587 858 3270634
SGTC_105 0111-0055 734.78 µM -0.710336961332152 0.284787204361571 no 2400 0.238747602262172 831 5179370
SGTC_1808 st050063 61.5 µM -0.71113471388523 0.284571432788562 no 2401 0.238500380142181 854 4011993
SGTC_1664 st014217 9.02 µM -0.712005322091262 0.284336044760303 no 2402 0.238230740189432 847 3982782
SGTC_2332 7982454 138.89 µM -0.712630067426314 0.284167188519645 no 2403 0.238037350491689 865 2981748
SGTC_1071 trifluoperazine 6.31 µM -0.715776734615125 0.28331743674521 no 2404 0.237064610180033 861 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.716063888626462 0.283239952038643 no 2405 0.236975950145793 835 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_1828 st055811 49 µM -0.717742570674177 0.282787185441062 no 2406 0.236458014727956 855 5877589
SGTC_520 3584-0023 682 µM -0.718394867358492 0.282611344751112 no 2407 0.236256925322724 821 1340790
SGTC_962 1254-0300 21.5 µM -0.718638177947523 0.282545768576139 no 2408 0.236181941886386 817 7340576
SGTC_441 propafenone 146 µM -0.720183614042852 0.282129419213778 no 2409 0.235705975701288 852 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_1531 st059297 52.4 µM -0.720273836930026 0.282105121777671 no 2410 0.235678205046193 850 7566702
SGTC_2962 9082311 13.18 µM -0.720335963658588 0.282088391351315 no 2411 0.235659083453576 859 16459453
SGTC_1043 0916-0009 19.3 µM -0.721031201255224 0.28190119983671 no 2412 0.235445159050297 855 3101130
SGTC_560 2332-1943 155 µM -0.722139498896439 0.281602916427613 no 2413 0.23510435789189 842 21177716
SGTC_329 k048-0121 21.3 µM -0.722941340775657 0.281387206408146 no 2414 0.234857961754542 847 6832902
SGTC_1359 1582-0056 520 nM -0.723020298235707 0.281365969731834 no 2415 0.234833706820532 855 3661189
SGTC_1297 1068-0111 14.1 µM -0.723038890203592 0.281360969283247 no 2416 0.234827995757234 840 767057
SGTC_1482 3346-2049 8.48 µM -0.723197243142181 0.281318380816546 no 2417 0.234779356161439 833 3826804
SGTC_135 0933-0004 26.348 µM -0.723463297100844 0.281246833545723 no 2418 0.234697647724333 828 21230617 YGL099W LSG1
SGTC_1747 st037496 66.6 µM -0.723575760488283 0.28121659251664 no 2419 0.234663113565823 855 723305
SGTC_1880 MG-132 525 µM -0.725335816074205 0.280743524135584 no 2420 0.234123019143017 833 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_722 3534-0461 190 µM -0.725607522158423 0.280670529182786 no 2421 0.234039704209808 838 658262
SGTC_2669 eugenol 100 µM -0.725624121551974 0.280666069985294 no 2422 0.234034614766434 820 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.727630390238326 0.280127366199557 no 2423 0.2334199360592 836 6708561
SGTC_3205 9113483 49.47 µM -0.728215568081041 0.279970334368502 no 2424 0.233240818681197 842 17018033
SGTC_614 0462-0418 107 µM -0.729095402167582 0.279734312215669 no 2425 0.232971653460244 822 5188303
SGTC_1990 st072050 59.8 µM -0.730145247898503 0.279452809545526 no 2426 0.232650702915388 840 17233948
SGTC_766 1391-0721 126 µM -0.730638757262408 0.279320528892306 no 2427 0.23249991609459 861 1020919 YIL115C NUP159
SGTC_2289 7946404 165.07 µM -0.732563252458767 0.278804976465749 no 2428 0.231912425429554 836 1246120 YPR165W RHO1
SGTC_1519 esterone 74 µM -0.732957596719137 0.278699392902073 no 2429 0.231792146094601 851 698 A steroid.
SGTC_1011 4112-3381 17.4 µM -0.73318193868657 0.278639335230469 no 2430 0.231723734840022 859 2877139
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.733549782975225 0.278540874778886 no 2431 0.231611588072108 838 17037758
SGTC_1942 st076330 65.2 µM -0.733608213137418 0.278525236405483 no 2432 0.231593776922815 857 24208414
SGTC_297 0986-0032 24 µM -0.734792032500545 0.278208488610228 no 2433 0.231233080103932 840 2847425
SGTC_2258 7960471 200 µM -0.735313271884785 0.278069079278579 no 2434 0.231074363591885 856 2974708
SGTC_438 sphingosine 6.67 µM -0.735414937965919 0.278041891904958 no 2435 0.231043413529594 830 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_2789 5281112 71.43 µM -0.735741531491594 0.277954563585518 no 2436 0.2309440047782 847 765948
SGTC_532 1548-0774 215 µM -0.736051694320713 0.277871641088443 no 2437 0.230849619324669 869 5932993
SGTC_1985 st071382 65.5 µM -0.736126356704204 0.277851681791868 no 2438 0.230826902079446 857 6123237
SGTC_2963 9082507 9 µM -0.737886885701946 0.277381247186534 no 2439 0.230291594424429 853 16459611
SGTC_1908 st060353 56.5 µM -0.738053760717961 0.277336676381167 no 2440 0.230240890338766 870 4227716
SGTC_685 1278-0033 54.9 µM -0.738860592208506 0.277121228410823 no 2441 0.229995826978495 859 3590572
SGTC_569 4130-2812 160 µM -0.740899056833323 0.276577262942666 no 2442 0.229377323707976 851 743552
SGTC_2142 5622915 118.518 µM -0.741242124841462 0.276485766527475 no 2443 0.229273323036434 852 5322196
SGTC_1111 tnp00062 510.699 nM -0.741443807670584 0.276431984540689 no 2444 0.229212195461062 843 676306
SGTC_2924 9010168 62.78 µM -0.741505400746253 0.276415560774084 no 2445 0.229193529182162 857 2993929
SGTC_941 3237-0776 460 µM -0.742029369877556 0.276275863990317 no 2446 0.229034770582477 855 760008
SGTC_3160 9100216 49.47 µM -0.743235831432979 0.275954337880803 no 2447 0.228669456724184 835 17191039
SGTC_2794 7785382 27.27 µM -0.743319802080514 0.275931966260345 no 2448 0.228644042784908 842 2205081
SGTC_1755 st041960 45.185 µM -0.744982967152923 0.27548904629769 no 2449 0.228141008408845 864 2257073
SGTC_2871 9038510 12.99 µM -0.746117983279194 0.27518697936614 no 2450 0.227798073442948 863 4945164
SGTC_252 miconazole 1.30953 nM -0.74742162807596 0.274840235867506 no 2451 0.227404547035638 846 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_3182 9108849 49.47 µM -0.748549747950295 0.274540352408483 no 2452 0.22706431499861 841 17133045
SGTC_907 3448-6986 75.5 µM -0.748617988058557 0.274522217600862 no 2453 0.227043743530909 863 590582
SGTC_1427 4048-4900 550 nM -0.750026265079593 0.274148100018222 no 2454 0.226619443056147 853 24132586
SGTC_1787 fluconazole 80 µM -0.750407075680495 0.274046978581561 no 2455 0.226504785366357 826 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_1765 st044815 90.4 µM -0.752457176044477 0.273502906509462 no 2456 0.225888086835555 864 645695
SGTC_1805 st050013 60.3 µM -0.752972568357447 0.273366211715564 no 2457 0.225733199187008 846 4037144
SGTC_1066 ketoconazole 628 nM -0.753058257023457 0.273343488241529 no 2458 0.225707453530702 856 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_2050 5263056 171 µM -0.753597199981913 0.273200589313568 no 2459 0.2255455630818 847 763468 YGL055W OLE1
SGTC_2714 st079313 56.9 µM -0.753687374899805 0.2731766833499 no 2460 0.225518482296844 851 2939799
SGTC_3057 9095946 49.47 µM -0.754947233319314 0.272842795039916 no 2461 0.225140321774102 866 24540043
SGTC_1186 1319-0216 26 µM -0.758741083543861 0.271838571120193 no 2462 0.224003727781637 871 4565136
SGTC_1641 st009299 47.1 µM -0.761171017466843 0.271196340498229 no 2463 0.223277463402385 838 4046054
SGTC_2482 5981709 142.65 µM -0.761364430631284 0.271145253992574 no 2464 0.223219713258468 879 877755
SGTC_381 3461-2219 42.7 µM -0.761429262149843 0.271128131021423 no 2465 0.223200357484514 870 2883159
SGTC_1986 st071812 45 µM -0.761532819855088 0.271100781005303 no 2466 0.223169441795979 858 11838594
SGTC_2081 5214970 32.255 µM -0.764107662080889 0.270421197305735 no 2467 0.222401543320542 862 2063512
SGTC_1046 2001-0062 216 µM -0.766214329809214 0.269865813874972 no 2468 0.221774391645273 864 739778
SGTC_1924 st058459 75.1 µM -0.768430849171711 0.269282087236279 no 2469 0.221115629330252 844 688683
SGTC_1628 st004252 77.7 µM -0.769928209316043 0.268888111905867 no 2470 0.22067123967148 857 692968
SGTC_826 1683-5028 118 µM -0.770457742822976 0.268748853920206 no 2471 0.220514206149993 858 722377
SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.773227424167055 0.268021067340054 no 2472 0.21969389935948 867 61125 An anti-inflammatory.
SGTC_2635 hydroquinidine 100 µM -0.7741863445904 0.267769324158531 no 2473 0.219410301180769 854 442912 An experimental heart treatment.
SGTC_68 0986-0284 82.829 µM -0.775511131521324 0.267421726983273 no 2474 0.219018845199592 841 423278 YIL048W NEO1
SGTC_591 4299-0174 154 µM -0.779664987220144 0.266333317238134 no 2475 0.217794046413217 867 5509088
SGTC_1667 st014849 34.6 µM -0.784172466217838 0.265154791169383 no 2476 0.216469459420956 860 5348460
SGTC_1974 st069448 26.9 µM -0.784494592847402 0.265070669408169 no 2477 0.216374976730295 846 6323587 YNR016C ACC1
SGTC_1070 indatraline 8.81 µM -0.784541156206278 0.265058510741015 no 2478 0.216361321245456 867 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_2011 4012611 177 µM -0.784712209185738 0.265013847661696 no 2479 0.216311161376658 867 2049887
SGTC_2735 sertaconazole 140 nM -0.785269158545491 0.264868450949311 no 2480 0.216147887242193 904 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_75 0159-0059 199.013 µM -0.785833537339771 0.264721156087859 no 2481 0.215982507938041 880 5377270
SGTC_2170 morpholine 200 µM -0.789957538892929 0.263646115871727 no 2482 0.214776283175338 856 121171 Reacts with secondary amines.
SGTC_2540 epiandrosterone 100 µM -0.790696294982657 0.263453773231944 no 2483 0.21456061932384 875 441302 A steroid.
SGTC_3105 9121040 49.47 µM -0.794247892794296 0.262530079708698 no 2484 0.213525566097817 818 41448907
SGTC_2666 tannic acid 100 µM -0.797759819714339 0.261618336491589 no 2485 0.212504941208965 858 16134267 A thiamine antagonist.
SGTC_416 estradiol valerate 100 µM -0.79794257998128 0.261570934005495 no 2486 0.212451906134606 879 13791 A steroid.
SGTC_3276 9139060 49.47 µM -0.798124530496787 0.261523745924265 no 2487 0.212399113723784 899 4870619
SGTC_1847 st056231 15 µM -0.798616315448079 0.261396225491968 no 2488 0.212256462119046 856 5393180
SGTC_2356 9061756 188.97 µM -0.799134892403811 0.261261792459632 no 2489 0.212106099658332 859 20104043
SGTC_1035 k081-0041 55.2 µM -0.800172435093132 0.260992932280274 no 2490 0.211805449039065 854 731709
SGTC_1489 4065-0444 182 µM -0.800258185958627 0.260970717880989 no 2491 0.211780612016774 853 2877968
SGTC_1571 st070080 73.4 µM -0.800609822567645 0.260879633972084 no 2492 0.211678781233416 867 4315245
SGTC_3121 9125696 49.47 µM -0.800611664605439 0.260879156874824 no 2493 0.211678247871388 902 1235365
SGTC_1546 5-methoxyflavanone 78.7 µM -0.801835379683371 0.260562307587165 no 2494 0.211324095044359 858 147795
SGTC_2310 7668677 200 µM -0.802196813895099 0.260468761484885 no 2495 0.211219559558306 873 2197143
SGTC_719 2810-4230 27.3 µM -0.802663224216542 0.260348071117866 no 2496 0.211084707237375 869 721079
SGTC_3348 9149464 3.537 µM -0.80287412008587 0.260293508243715 no 2497 0.21102374789052 866 1951442
SGTC_2063 5246145 200 µM -0.804162544837907 0.25996029562987 no 2498 0.210651553521304 882 711240
SGTC_2664 lyso-paf C-16 73.48 µM -0.805967806981831 0.259493788791813 no 2499 0.21013070589108 871 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_573 3702-0553 84.7 µM -0.810922432610364 0.258215664410301 no 2500 0.208705108472106 868 1222756
SGTC_2868 9035608 32.47 µM -0.813661937456397 0.257510369230489 no 2501 0.207919322438566 877 6462614
SGTC_123 0083-0120 66.675 µM -0.814112875886328 0.257394369530977 no 2502 0.207790145133343 899 16001701
SGTC_1893 st059353 36.1 µM -0.814164465297057 0.257381100367922 no 2503 0.207775369683452 909 3112488
SGTC_328 k915-0120 63.5 µM -0.814330835512868 0.257338311187734 no 2504 0.207727724698872 869 6624543
SGTC_2385 9074692 200 µM -0.814517651992399 0.257290267787521 no 2505 0.207674232020911 876 17046906
SGTC_74 000s-0487 160.283 µM -0.815688320173291 0.256989314439905 no 2506 0.20733921043402 861 677548
SGTC_1881 5652484 16 µM -0.817148487909871 0.256614193869735 no 2507 0.206921788088551 879 2255129
SGTC_1194 1488-0194 225 µM -0.817592463989581 0.256500191916697 no 2508 0.206794966041055 876 1391452
SGTC_502 l-744,832 89.3 µM -0.81772940008293 0.256465035477348 no 2509 0.206755859446489 892 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_551 k048-0028 34.9 µM -0.821263768289786 0.255558504906919 no 2510 0.205748020352018 880 6836383
SGTC_1777 st045864 34.765 µM -0.825258880872635 0.254535816913077 no 2511 0.204612315574049 909 4691462
SGTC_1590 st077108 57.8 µM -0.825974088373531 0.254352961217588 no 2512 0.204409395357106 864 5489485
SGTC_47 0149-0135 24.25 µM -0.82610607339126 0.254319224394905 no 2513 0.204371961379915 874 5239155
SGTC_1526 st051518 75 µM -0.827379845337379 0.253993754869478 no 2514 0.204010900242797 888 673993
SGTC_2785 7756463 72.73 µM -0.828031556178272 0.253827316665496 no 2515 0.203826314503775 895 2201551
SGTC_1712 st032288 53.4 µM -0.829211878108855 0.253526024089605 no 2516 0.203492262401275 880 2883011
SGTC_1370 2001-0092 44.6 µM -0.830127115738792 0.253292527144772 no 2517 0.203233458805835 866 790957
SGTC_1678 st019265 80.2 µM -0.831968184561305 0.252823173291886 no 2518 0.202713451485809 876 5367020
SGTC_3259 9138485 49.47 µM -0.833446048635864 0.252446744775774 no 2519 0.20229660667368 862 17646153
SGTC_1262 0737-0114 49.6 µM -0.834462618878158 0.252187984527236 no 2520 0.202010171777727 892 765919
SGTC_1999 st074831 12.5 µM -0.834863579607407 0.252085961493427 no 2521 0.201897261476323 888 17112523
SGTC_2441 5730946 39.09 µM -0.835140542495302 0.252015501986531 no 2522 0.20181929095969 859 1774275
SGTC_1216 1165-0504 9.65 µM -0.836546142476524 0.251658076848591 no 2523 0.201423864859197 892 6304004
SGTC_1273 0849-0096 14.1 µM -0.837177746489229 0.25149755568716 no 2524 0.201246332101844 888 5286025
SGTC_538 2922-0838 53.3 µM -0.838731164321609 0.25110298728778 no 2525 0.20081009302359 897 777039
SGTC_1984 st072354 53.1 µM -0.839204589716384 0.250982802295475 no 2526 0.200677256097844 876 5762938
SGTC_1000 4048-0884 8.67 µM -0.839890613767149 0.250808700488578 no 2527 0.200484860422655 903 13040088
SGTC_1972 st070201 17.4 µM -0.842712574383445 0.250093205536215 no 2528 0.19969460646428 889 2829099
SGTC_2098 5376439 882.5 nM -0.842861298634111 0.250055527256213 no 2529 0.19965301019506 878 2844116
SGTC_1164 k060-0068 93.7 µM -0.844135363670723 0.249732874969146 no 2530 0.19929688419039 885 5963676
SGTC_1921 5740136 50 µM -0.845012879434197 0.249510775967553 no 2531 0.199051824049498 876 1774243
SGTC_1119 parthenolide 318.541 nM -0.845092836643379 0.24949054403821 no 2532 0.19902950376449 930 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_890 0929-0006 47.2 µM -0.845327635672478 0.249431136831472 no 2533 0.198963967657178 892 1378169
SGTC_3299 9121982 43.1275 µM -0.846676503040432 0.2490900015548 no 2534 0.198587729542318 886 17594604 YPL160W CDC60
SGTC_2138 5575593 77.673 µM -0.847194548782309 0.248959051202545 no 2535 0.198443345730414 879 762213
SGTC_1064 honokiol 6.76 µM -0.849097134808538 0.248478434619325 no 2536 0.197913622297229 890 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_2379 9035213 200 µM -0.849197196425064 0.248453171519186 no 2537 0.197885786519172 865 646551
SGTC_2605 digitonin 300 nM -0.849904172894294 0.248274716335768 no 2538 0.197689182694642 879 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_1471 k673-0312 37 µM -0.850865835818524 0.248032082880797 no 2539 0.197421942428496 868 24099884
SGTC_2247 cerulenin 830 nM -0.850942908089767 0.248012642551428 no 2540 0.197400533974066 866 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_2284 7945075 39.21 µM -0.851432662935345 0.247889128205567 no 2541 0.197264527009877 890 1245402
SGTC_1809 st050081 57.6 µM -0.851835716201398 0.247787504308125 no 2542 0.197152639969358 879 5036894
SGTC_2930 9013230 14.89 µM -0.852157966876983 0.24770626958825 no 2543 0.197063211248328 854 2995857
SGTC_49 0717-0965 32.132 µM -0.852475356457907 0.247626274183698 no 2544 0.196975155545493 899 5889349 YGL099W LSG1
SGTC_206 4546-0025 72.014 µM -0.853127018428216 0.247462071463856 no 2545 0.19679443488872 885 6620745 YIL048W NEO1
SGTC_1045 1348-1485 165 µM -0.853655329757103 0.247328992777881 no 2546 0.196647995888117 895 6810614
SGTC_1294 1000-1494 117 µM -0.854541903613304 0.247105755750328 no 2547 0.196402400929663 876 712797 YDL207W GLE1
SGTC_1423 4048-0112 5.59 µM -0.85463728199888 0.247081746139766 no 2548 0.196375990690894 878 X1423
SGTC_3251 9135047 49.47 µM -0.854925745134043 0.247009138881031 no 2549 0.196296128459337 876 17682963
SGTC_804 1595-0054 20.9 µM -0.857085810065948 0.246465805385283 no 2550 0.19569873137183 891 761523 Stimulates phospholipase C.
SGTC_2171 5739187 198.077 µM -0.858170503319302 0.246193208012717 no 2551 0.195399160526042 870 2262761
SGTC_225 nsc-122657 1.016 µM -0.858250478867995 0.246173115529919 no 2552 0.195377083891474 891 275685
SGTC_2056 5235370 200 µM -0.859132682552044 0.245951535372583 no 2553 0.19513365891103 898 5511916
SGTC_3230 9131665 49.47 µM -0.860125391194701 0.245702328078491 no 2554 0.194859963013959 875 15943720
SGTC_15 0266-0086 27.098 µM -0.86119995896401 0.245432723949924 no 2555 0.19456396133726 915 1712902 YIL048W NEO1
SGTC_1701 st028638 40.4 µM -0.86289761075149 0.245007115058284 no 2556 0.194096882221587 896 3490878
SGTC_1721 st082152 9.2685 µM -0.863106719502861 0.24495471803951 no 2557 0.194039396904743 906 5296051
SGTC_2099 5377090 177.372 µM -0.865746488926177 0.244293781730446 no 2558 0.193314599938524 894 2243829
SGTC_1883 5-benzylidenerhodanine 20 µM -0.866279768645125 0.244160377812228 no 2559 0.193168379083882 865 1273210
SGTC_3055 9094636 49.47 µM -0.867381441830865 0.243884910450809 no 2560 0.192866523354426 901 25236176
SGTC_1128 3448-9350 235 µM -0.870032779279364 0.24322264606319 no 2561 0.192141245475877 882 619386
SGTC_1629 st005085 44.9 µM -0.871058360800302 0.242966732160646 no 2562 0.191861144062108 884 24207091
SGTC_3224 9130643 49.47 µM -0.873666517646196 0.242316574165546 no 2563 0.191149945012477 887 17644395
SGTC_2786 7743617 45.45 µM -0.875356103130589 0.24189590019214 no 2564 0.19069008830975 893 583674
SGTC_1967 st070177 51.4 µM -0.876199052481432 0.241686170414968 no 2565 0.190460915773983 906 5729214
SGTC_3168 9103419 49.47 µM -0.876271985420262 0.241668028996352 no 2566 0.190441095457489 883 16649256
SGTC_1819 st053448 58.6 µM -0.876632393075564 0.241578391657008 no 2567 0.190343169367323 928 2857616
SGTC_2812 7970281 58.44 µM -0.878583471799139 0.241093450512084 no 2568 0.189813580343506 924 2233435
SGTC_3006 9075424 71.4286 µM -0.880676917505286 0.240573713173387 no 2569 0.189246356826211 898 7465181
SGTC_841 0251-0215 91.2 µM -0.881494708242526 0.240370847030688 no 2570 0.189025058466014 899 3888614
SGTC_1909 st060837 51.5 µM -0.883598587734858 0.239849374411606 no 2571 0.188456470843977 881 678937
SGTC_2793 7325131 81.82 µM -0.88424498488431 0.239689280881946 no 2572 0.188281989696548 878 4176441
SGTC_2214 7179297 48.276 µM -0.886272308781902 0.239187550960061 no 2573 0.187735403555057 890 769744
SGTC_2279 7948423 32.93 µM -0.886844490487745 0.239046049146856 no 2574 0.187581315353725 885 1247112
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.886915582280345 0.239028471184502 no 2575 0.187562175834577 924 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_2908 7930301 100 µM -0.887056927120307 0.238993524744854 no 2576 0.187524126190252 877 2223178
SGTC_3353 9151644 39.2805 µM -0.887358811833832 0.238918895394358 no 2577 0.187442875626038 900 4909158
SGTC_860 0443-0016 25.1 µM -0.887615307393896 0.23885549677626 no 2578 0.187373858396251 893 5337942
SGTC_793 0488-0545 106 µM -0.889141710560929 0.238478402446023 no 2579 0.186963462360532 901 292548
SGTC_3226 9131256 49.47 µM -0.889978136814597 0.238271903616433 no 2580 0.186738812865492 866 17178073
SGTC_1055 3448-0672 86 µM -0.890690722715119 0.238096056073458 no 2581 0.186547556600364 888 748378
SGTC_850 0388-0143 75.9 µM -0.891761997802525 0.237831827317781 no 2582 0.186260257414337 894 67273
SGTC_1746 st038117 42 µM -0.892079741174548 0.237753487217733 no 2583 0.186175096370443 881 2898218
SGTC_10 0279-0212 42.575 µM -0.892277906770155 0.23770463636354 no 2584 0.186121996581046 897 39851 YBR002C RER2
SGTC_357 1325-0123 420 µM -0.89829156539832 0.236224799483986 no 2585 0.184515064038681 931 1098503
SGTC_2419 paclitaxel 166.5 µM -0.89869265537549 0.236126280356793 no 2586 0.184408195099803 907 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1117 retinoic acid 1.10837 µM -0.900164947253714 0.235764837626132 no 2587 0.184016238573366 916 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_3132 9126706 49.47 µM -0.900223539768987 0.235750459674371 no 2588 0.18400065069489 900 850858
SGTC_2326 6164455 177.58 µM -0.903406245120138 0.234970186025549 no 2589 0.183155163357863 911 2888790
SGTC_370 0180-0345 38.7 µM -0.904271740553983 0.234758247772816 no 2590 0.182925663801267 881 3989527
SGTC_1545 lovastatin 49.4 µM -0.90543905191142 0.234472569792293 no 2591 0.182616417450562 891 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_2716 st080858 38.6235 µM -0.90595720143568 0.234345823889693 no 2592 0.182479252972716 885 5296050
SGTC_1856 st057054 55.7 µM -0.905958688770717 0.234345460123387 no 2593 0.182478859338222 900 1266018
SGTC_3200 9114385 49.47 µM -0.906111645010467 0.234308052381939 no 2594 0.182438381141744 891 17018030 YLR208W SEC13
SGTC_375 3970-0961 9.27 µM -0.906425751663496 0.234231243254564 no 2595 0.182355273839013 880 2898222
SGTC_1289 0976-0073 69.1 µM -0.907512295565541 0.23396565603816 no 2596 0.182067975191355 910 3391136
SGTC_2725 haloperidol 53.21 µM -0.908386839002313 0.233752009970516 no 2597 0.181836938342543 900 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_256 clotrimazole 625 nM -0.909235648816958 0.23354475393463 no 2598 0.181612875250469 863 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_587 k089-0003 57 µM -0.909609710416678 0.233453450731185 no 2599 0.181514187863204 875 9659696
SGTC_2316 5844804 197.44 µM -0.910825242168072 0.233156893191357 no 2600 0.181193730112478 898 776813
SGTC_3257 9139206 32.98 µM -0.911056224654806 0.233100563240256 no 2601 0.181132874938199 906 4910041
SGTC_2687 chenodiol 100 µM -0.911187607938692 0.233068526027019 no 2602 0.181098266110824 887 5702181 A cholesterol synthesis inhibitor.
SGTC_2409 alverine citrate 63.97 µM -0.911612316939493 0.232964979406423 no 2603 0.180986418117146 890 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_2260 7964312 200 µM -0.911667442611861 0.232951541308095 no 2604 0.180971903831775 905 231951
SGTC_211 3455-0679 143.504 µM -0.912309853396278 0.232794971260016 no 2605 0.180802814398311 889 748649
SGTC_1455 4262-0120 131 µM -0.914381118945153 0.232290555377042 no 2606 0.180258309725422 910 1529587
SGTC_3296 9122258 64.045 µM -0.914815972022408 0.232184732772842 no 2607 0.180144124212008 916 4730474
SGTC_678 1218-2179 85.9 µM -0.915026554542357 0.232133496623837 no 2608 0.180088844907255 920 6820081 YOR116C RPO31
SGTC_1301 naphtanilide LB 4.81 µM -0.91790039063883 0.23143490220239 no 2609 0.179335508564302 896 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.918758688665519 0.231226488011787 no 2610 0.179110902446651 880 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_2821 7996764 71.43 µM -0.918955095717395 0.231178810659481 no 2611 0.179059530010173 870 2987135
SGTC_279 1273-0055 2.93 µM -0.919711565056123 0.230995230754879 no 2612 0.178861753713162 934 2847562
SGTC_1505 k297-0037 20.6 µM -0.92209237441144 0.230417987605846 no 2613 0.178240197107381 892 4089396
SGTC_178 4092-0806 87.505 µM -0.923108810723285 0.230171791677002 no 2614 0.177975251775363 886 2169044
SGTC_336 4111-0029 111 µM -0.925492553209349 0.229594991558537 no 2615 0.177354877750705 917 3131175
SGTC_3287 9117173 37.0625 µM -0.925627376857048 0.229562392157012 no 2616 0.177319830455062 877 2789709
SGTC_1438 4092-1045 4 µM -0.927355634066093 0.229144741581626 no 2617 0.176870958809092 897 1351342
SGTC_1244 0416-0015 52.5 µM -0.928236446900392 0.228932048438895 no 2618 0.176642466198187 908 96201
SGTC_661 1304-0007 33.6 µM -0.928461973797104 0.228877607442427 no 2619 0.176583992048783 910 3117130
SGTC_1357 1503-1303 39.5 µM -0.930449326945698 0.228398185179679 no 2620 0.176069244544397 894 292895
SGTC_191 3914-0123 66.505 µM -0.932840843408474 0.227822012784936 no 2621 0.17545107479204 926 3144412
SGTC_3066 9117245 49.47 µM -0.935192120691642 0.227256333233016 no 2622 0.174844649205704 894 17176980
SGTC_3157 9099274 49.47 µM -0.938814652787577 0.226386361332985 no 2623 0.173912957230817 884 17217662
SGTC_775 4577-0580 57.3 µM -0.939086330200006 0.226321192348476 no 2624 0.173843211038244 929 2006902
SGTC_910 3454-3003 490 µM -0.941305279234311 0.225789315862208 no 2625 0.17327421906788 937 820824
SGTC_895 0964-0006 13.7 µM -0.941425986950278 0.225760402817187 no 2626 0.17324330074777 923 6738897
SGTC_1306 1185-0270 9.02 µM -0.943213069314238 0.225332589177529 no 2627 0.172785964903465 924 1548076
SGTC_1460 k062-0059 9.15 µM -0.946347763356629 0.224583277757472 no 2628 0.171985619603539 890 1373085
SGTC_3100 9120536 49.47 µM -0.946629218252378 0.224516068533065 no 2629 0.171913874942495 897 16421196
SGTC_578 3460-0051 92 µM -0.947269489577155 0.224363219274234 no 2630 0.171750736862772 939 2876744
SGTC_2755 lomerizine 42.69 µM -0.947470213187862 0.224315313541556 no 2631 0.171699613809305 899 3949 A calcium channel blocker.
SGTC_2654 protoveratrine a 100 µM -0.948983825197177 0.223954254133293 no 2632 0.171314419329252 925 5702278 A heart drug and vasodilator.
SGTC_209 4077-0173 175.592 µM -0.949791966474526 0.2237616141326 no 2633 0.171108984332339 903 15993494
SGTC_86 0417-1630 471.922 µM -0.951031319187886 0.223466367547921 no 2634 0.170794238688695 903 3634867
SGTC_2190 6049624 200 µM -0.951111801474721 0.223447202205499 no 2635 0.170773812250919 897 2265554
SGTC_2152 5568786 200 µM -0.951364672990963 0.223386991696527 no 2636 0.170709643529071 915 5399883
SGTC_746 1095-0025 46.6 µM -0.951497194024507 0.223355441181692 no 2637 0.170676021131721 918 6749286
SGTC_496 calpeptin 138 µM -0.952259635421945 0.22317396893734 no 2638 0.17048266168867 910 73364 A calpain inhibitor.
SGTC_1451 4152-0210 104 µM -0.953760959990484 0.222816877137431 no 2639 0.170102327546616 935 659563
SGTC_459 nigericin 15.3 µM -0.954016081874488 0.22275622847859 no 2640 0.170037751004558 925 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_3326 9140064 16.379 µM -0.955202149276415 0.222474395058608 no 2641 0.169737739570015 924 1868434
SGTC_700 3453-2283 142 µM -0.95596709117263 0.222292737428634 no 2642 0.169544430489816 913 565664
SGTC_2222 6885208 172.143 µM -0.956121491537584 0.222256080853138 no 2643 0.169505428989132 925 609514
SGTC_1907 st060210 83.7 µM -0.956751871242705 0.222106456627922 no 2644 0.169346254940821 919 688793
SGTC_2010 4012422 159 µM -0.959018308167508 0.221568980086533 no 2645 0.168774761064966 921 952393
SGTC_2002 4023503 131 µM -0.959619485270971 0.221426538160516 no 2646 0.168623379334178 936 4736863 YCR052W RSC6
SGTC_2148 5546263 113.568 µM -0.959659142933041 0.221417143579684 no 2647 0.168613396252457 940 792097
SGTC_927 2425-1185 123 µM -0.960029543923487 0.221329409572751 no 2648 0.168520173011109 924 730375
SGTC_1433 4060-0023 7.6 µM -0.960596823168519 0.221195081089734 no 2649 0.168377463319429 914 3840627
SGTC_2909 7941780 10.49 µM -0.961513514918512 0.220978112329722 no 2650 0.16814701670904 897 1243215
SGTC_426 0988-0037 14.6 µM -0.962115688937849 0.220835652056229 no 2651 0.16799574701853 933 5383008
SGTC_1690 st023502 41.2 µM -0.964453006793941 0.220283195819359 no 2652 0.167409428951655 901 24207482
SGTC_2303 7774051 200 µM -0.965405673928941 0.220058247748514 no 2653 0.16717083033553 915 2953184
SGTC_365 0121-0052 13.6 µM -0.965707453573431 0.219987017667457 no 2654 0.167095294376254 887 3101739
SGTC_981 1488-1094 54.9 µM -0.967254392390419 0.219622096184786 no 2655 0.166708438553221 911 3449522
SGTC_758 0868-0029 16 µM -0.967280711900735 0.219615890444966 no 2656 0.166701861619024 890 762687
SGTC_951 1171-0579 82.7 µM -0.971503657892718 0.218621489151471 no 2657 0.165648766242771 911 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_1442 4112-3290 3 µM -0.974516626007406 0.217913595458565 no 2658 0.1649000440317 945 704353
SGTC_3328 9140624 29.0385 µM -0.975998207517026 0.217565984795553 no 2659 0.164532676303112 926 4904392
SGTC_2914 7968218 45.32 µM -0.977380807140339 0.217241886256617 no 2660 0.164190330598976 901 2977111
SGTC_794 k038-0031 316 µM -0.980264543251513 0.21656680077789 no 2661 0.163477776006109 908 6624242
SGTC_3295 9122362 53.5725 µM -0.980788500848843 0.216444272207742 no 2662 0.163348525026046 969 4730473
SGTC_2359 9039622 200 µM -0.981431288187634 0.216294009867296 no 2663 0.163190051573052 932 6463596
SGTC_1269 0831-0796 3.05 µM -0.983133208802826 0.215896449080859 no 2664 0.162770940942134 898 927758
SGTC_3327 9140648 26.9345 µM -0.984858743918648 0.215493804681008 no 2665 0.162346730390702 925 8029710
SGTC_488 nitrendipine 139 µM -0.985258516487598 0.215400582069992 no 2666 0.16224855191314 952 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_1578 josamycin 24.2 µM -0.986475420709359 0.215116957297183 no 2667 0.161949935450963 919 5282165 A P450 substrate.
SGTC_2360 9040895 200 µM -0.986848318328671 0.215030089188353 no 2668 0.161858501711857 935 4914414
SGTC_3345 9148410 3.559 µM -0.989315870029874 0.214455775950405 no 2669 0.161254310893592 893 4903596
SGTC_1120 ficusin 1.78878 µM -0.991846846069448 0.213867628568322 no 2670 0.160636120777076 947 6199 A DNA cross-linker.
SGTC_1354 1498-1681 81 µM -0.992256312252114 0.213772565293404 no 2671 0.16053625444459 942 5754243
SGTC_2581 avocatin a 64 µM -0.992429562534636 0.21373235023865 no 2672 0.160494011958969 944 6710728 A skin care supplement.
SGTC_1738 st035555 74 µM -0.992582428129851 0.2136968705605 no 2673 0.16045674576961 935 5331140
SGTC_1478 0453-0656 35.7 µM -0.992666799349201 0.213677289705303 no 2674 0.160436179836068 953 5258496
SGTC_2499 avocadenofuran 51.48 µM -0.994356551757863 0.213285352444317 no 2675 0.160024656374202 940 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_2611 pyromycin 23.93 µM -0.994849617331745 0.213171065173337 no 2676 0.159904705054192 916 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_2045 5106652 78.05 µM -0.995575511073166 0.213002875864106 no 2677 0.1597282191368 907 673349
SGTC_2115 tiliquinol 12.7705 µM -0.996487463329122 0.212791686642319 no 2678 0.159506677678516 931 71208 A bioactive hydroxyquinoline.
SGTC_2243 6634756 200 µM -0.997476030762085 0.212562893062433 no 2679 0.159266751323458 925 885676
SGTC_3302 9125395 16.351 µM -0.998329701485311 0.212365435573149 no 2680 0.159059754809777 907 17599668
SGTC_1406 3909-7906 11.9 µM -0.998705767065616 0.212278484104491 no 2681 0.158968623067417 911 X1406
SGTC_739 1486-1183 203 µM -1.0022131833759 0.211468524407315 no 2682 0.158120320954175 929 4346692
SGTC_734 2023-0417 80 µM -1.00552489325072 0.210705422411394 no 2683 0.157322084501011 949 3935732
SGTC_745 0469-0705 296 µM -1.00665027480265 0.210446474147229 no 2684 0.157051432797199 938 3486736
SGTC_1751 st044839 27.194 µM -1.00895959906593 0.209915688139848 no 2685 0.156497005153599 905 5291326
SGTC_2267 7931562 200 µM -1.01112493165886 0.209418713338873 no 2686 0.155978319494568 936 934880
SGTC_307 1501-1223 22.3 µM -1.01163571443482 0.209301582381656 no 2687 0.15585613150071 927 2830329
SGTC_2498 4'-Methoxychalcone 54.63 µM -1.01284699284518 0.209023970350578 no 2688 0.15556662527332 937 641818 YHR062C RPP1
SGTC_2454 5-benzylidenerhodanine 10.36 µM -1.01474557580567 0.208589272100527 no 2689 0.155113561409834 934 1273210
SGTC_1929 genistein trimethyl ether 50.5 µM -1.01582631831412 0.208342064257369 no 2690 0.154856050449692 904 136420
SGTC_1352 1496-0991 99 µM -1.01872186766378 0.207680591882767 no 2691 0.154167513957703 958 3000039
SGTC_471 1-acyl-paf 4 µM -1.02019734696324 0.207344004474082 no 2692 0.153817437812106 919 16759367
SGTC_1312 1218-2183 165 µM -1.02037775365131 0.207302872109704 no 2693 0.15377467016942 923 6744073
SGTC_414 piperonyl butoxide 100 µM -1.02091873194309 0.20717955907032 no 2694 0.153646471751781 936 5794 A potent inhibitor of cytochrome P450.
SGTC_2484 5809818 12.04 µM -1.02142837940264 0.207063427421573 no 2695 0.153525762716487 928 2870548
SGTC_2030 5175110 200 µM -1.021809963365 0.206976502388208 no 2696 0.153435426403865 957 2831986
SGTC_1240 0356-0016 42.1 µM -1.02609601701204 0.206001621360264 no 2697 0.152423163772226 890 4305613
SGTC_1537 2',6'-dihydroxyflavanone 78 µM -1.02716125013171 0.205759752777248 no 2698 0.152172270600065 956 5106787 A p450 inhibitor.
SGTC_3131 9127911 49.47 µM -1.0291838767449 0.205300965382105 no 2699 0.151696638662022 931 45595681
SGTC_2120 5538279 151.968 µM -1.03247781475729 0.204555111570846 no 2700 0.15092416765937 931 2058197
SGTC_789 1309-1135 70.6 µM -1.03279410241482 0.204483578788161 no 2701 0.150850132133026 920 3092424
SGTC_3329 9141233 27.5565 µM -1.03329769382833 0.20436971542532 no 2702 0.150732303087709 931 4909101 YNL103W MET4
SGTC_476 mead acid 10 µM -1.03627061791236 0.203698298838309 no 2703 0.15003795482384 952 5312531 An omega 9 fatty acid.
SGTC_1257 0669-0121 16 µM -1.03629870435507 0.203691961965826 no 2704 0.150031405213804 924 4307855
SGTC_1640 st009078 66.4 µM -1.03785342896935 0.203341367846109 no 2705 0.149669148975376 936 690618
SGTC_646 4092-0839 27.3 µM -1.03986654158954 0.20288794150506 no 2706 0.149200954471484 930 877796
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -1.04016309290793 0.202821198412354 no 2707 0.149132067550008 942 368090
SGTC_1799 st045822 46.1415 µM -1.04357568986627 0.202054089313492 no 2708 0.148340872561924 895 3674992
SGTC_1697 st025554 27.742 µM -1.04428597730601 0.20189464416651 no 2709 0.148176549330924 936 1269519
SGTC_2254 7938975 95.19 µM -1.04767619506009 0.201134647322106 no 2710 0.147393909402984 960 2969277
SGTC_422 cantharidin 155 µM -1.04893211364754 0.200853539791654 no 2711 0.147104682011839 953 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_3110 9122132 49.47 µM -1.04901165904118 0.200835743388124 no 2712 0.147086376205323 938 918317
SGTC_31 0508-1974 57.237 µM -1.04944106468494 0.200739690357702 no 2713 0.146987583327328 904 6810525
SGTC_2641 levomentholum 100 µM -1.05057250174957 0.200486733173721 no 2714 0.146727488003949 933 16666
SGTC_2103 5378138 10 µM -1.05097367493186 0.200397088240604 no 2715 0.146635340312102 927 244142
SGTC_2699 st077704 54.6 µM -1.05320920239232 0.199897985193654 no 2716 0.146122560892812 938 645852
SGTC_3054 9094397 49.47 µM -1.05467448537299 0.199571252592344 no 2717 0.145787112395217 954 2598354
SGTC_2302 7771753 200 µM -1.06130134188324 0.198097597080183 no 2718 0.144276488059031 930 2203047
SGTC_1512 0259-0544 12.2 µM -1.06345084299165 0.197621013910807 no 2719 0.143788773135404 922 18476
SGTC_2881 9058953 51.95 µM -1.06402040863208 0.197494847178911 no 2720 0.143659727156848 914 17122249
SGTC_1559 coumarin 343 70.1 µM -1.06439977847717 0.197410838496672 no 2721 0.143573817050049 941 108770 A hepatotoxic, DNA x-linker.
SGTC_1552 6-methylflavone 10.6 µM -1.06508483331376 0.19725919286049 no 2722 0.143418770984649 942 689013
SGTC_2614 arthonioic acid 13.39 µM -1.06529072908839 0.197213628977902 no 2723 0.143372193416512 965 6710684
SGTC_2578 7,8-dihydroxyflavone 64.44 µM -1.06530462165281 0.197210554840232 no 2724 0.143369051020211 924 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_2102 5377816 72.7585 µM -1.06644217536416 0.196958936077086 no 2725 0.143111902506646 940 1379702
SGTC_220 paclitaxel 373.376 µM -1.06675644482582 0.19688945619078 no 2726 0.143040915617557 945 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2993 9054257 71.4286 µM -1.06718658939933 0.196794382253293 no 2727 0.142943793539067 921 6470217 YGL055W OLE1
SGTC_1824 st053723 68.6 µM -1.06933197431131 0.196320607663525 no 2728 0.142460053908476 953 675225
SGTC_203 k066-0004 30.888 µM -1.0694276646219 0.196299492080353 no 2729 0.142438503561588 983 6795412
SGTC_1681 tripelennamine 100 µM -1.07175738077253 0.195785828212603 no 2730 0.141914510186962 917 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_2722 naftopidil 47.16 µM -1.07273418436886 0.195570702128416 no 2731 0.141695199021514 948 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_1096 rimcazole 32.2 µM -1.07304789576185 0.195501642443958 no 2732 0.141624813519256 924 18528119 A dopamine reuptake inhibitor.
SGTC_2129 girgensonine 121.053 µM -1.07418435169863 0.195251589749246 no 2733 0.141370032212658 949 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1278 0874-0585 172 µM -1.0759797971533 0.194856936846465 no 2734 0.140968145922364 955 766306
SGTC_677 0929-0063 136 µM -1.07713779172676 0.194602658154826 no 2735 0.140709355894746 982 1539583
SGTC_317 4495-0002 170 µM -1.07964532154833 0.194052733676728 no 2736 0.140150075612153 938 15991618
SGTC_1405 3909-7894 12 µM -1.07992782294836 0.193990837904357 no 2737 0.140087161188205 918 7104060
SGTC_3155 9099265 49.47 µM -1.08074778889731 0.193811252333189 no 2738 0.139904659504684 957 25236499
SGTC_69 0096-0274 206.684 µM -1.0815771803874 0.19362970555198 no 2739 0.139720224412081 963 6741392
SGTC_743 1275-0778 158 µM -1.08205814655207 0.193524473649763 no 2740 0.139613345806422 947 2849257 YMR203W TOM40
SGTC_1496 4469-0713 57.4 µM -1.08244511386069 0.193439833343042 no 2741 0.13952739566408 981 746691
SGTC_283 0987-0079 11.7 µM -1.08620611647053 0.192618376394061 no 2742 0.138693905915454 951 411556
SGTC_2730 imipramine 71.33 µM -1.08637495267771 0.192581550214797 no 2743 0.138656569207845 933 3696 A tricyclic antidepressant.
SGTC_2678 equilin 100 µM -1.08950134571885 0.191900406171729 no 2744 0.137966430868473 901 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_2511 berberine 10.47 µM -1.08974421806251 0.191847553626467 no 2745 0.137912916053313 946 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_3319 9138450 16.7555 µM -1.09031413386994 0.191723566674544 no 2746 0.137787395651354 926 2029690
SGTC_320 4092-0846 5.34 µM -1.09161216843164 0.191441358435543 no 2747 0.137501802655638 936 1359356
SGTC_475 α-linolenic acid 10 µM -1.09178186673167 0.191404482817992 no 2748 0.13746449560132 943 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -1.09197735293707 0.191362008857257 no 2749 0.137421527812306 941 688803
SGTC_210 3551-0445 56.827 µM -1.09436253638028 0.190844237155892 no 2750 0.136898003974445 963 2865180 YOR207C RET1
SGTC_715 0868-0130 184 µM -1.09481183927818 0.190746799515806 no 2751 0.136799539267539 988 2876258
SGTC_3243 9134147 49.47 µM -1.09523704674221 0.190654615431324 no 2752 0.136706399671223 939 24282180
SGTC_2593 nobiletin 86.24 µM -1.09539846229552 0.19061962804049 no 2753 0.136671053746873 934 72344 An anti-infammatory.
SGTC_2757 clomiphene 4.22 µM -1.09623898743231 0.19043750495342 no 2754 0.136487100985464 961 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_1954 st077032 68.9 µM -1.09897318430781 0.189845804875191 no 2755 0.135889881319471 970 698907
SGTC_943 3253-1379 105 µM -1.10023079048124 0.189574029718706 no 2756 0.135615789119565 944 668464
SGTC_2763 lisinopril 49.32 µM -1.10117078708313 0.189371048026827 no 2757 0.135411166659779 944 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_3119 9125183 49.47 µM -1.1021038737324 0.189169690817757 no 2758 0.135208257753887 921 22695334
SGTC_1145 3546-0597 10.2 µM -1.1029090271837 0.18899604720315 no 2759 0.13503333681082 947 875334
SGTC_1555 citronellol 128 µM -1.10497778244755 0.188550339037345 no 2760 0.134584608157775 960 8842 A terpine precursor.
SGTC_1677 st019204 53.9 µM -1.10658534051911 0.188204442539745 no 2761 0.134236624109383 954 3945625
SGTC_3253 9135987 49.47 µM -1.10847384701807 0.187798595222325 no 2762 0.133828613905578 956 4182430
SGTC_2957 9076800 11.52 µM -1.10897846229596 0.187690243032416 no 2763 0.133719736673179 984 16459615
SGTC_3262 9137218 49.47 µM -1.10964260796203 0.187547694974082 no 2764 0.133576531548409 923 17650664
SGTC_2217 6934799 96.0675 µM -1.10971138064283 0.187532937860805 no 2765 0.133561708600184 954 675606
SGTC_2826 7992541 19.48 µM -1.10979436178133 0.18751513287849 no 2766 0.133543824732062 996 2985066
SGTC_1614 st002383 48.6 µM -1.11052709787063 0.187357957516424 no 2767 0.133385978926217 930 1947235
SGTC_1246 0422-0085 105 µM -1.11263758260128 0.186905703844348 no 2768 0.132932056284324 951 264295
SGTC_2643 anethole 100 µM -1.11331039970695 0.186761668657497 no 2769 0.132787570741667 982 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_953 1188-0045 9.7 µM -1.11523307284152 0.186350445914421 no 2770 0.132375278465012 948 6144426
SGTC_2425 5628681 7.85 µM -1.11615547733549 0.186153360631496 no 2771 0.132177794289185 956 5714958
SGTC_262 fenpropimorph 62.5 µM -1.11719660376354 0.185931063924251 no 2772 0.131955136214347 991 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_3340 9146634 11.102 µM -1.11797226106012 0.185765556057125 no 2773 0.131789420329362 940 4907387
SGTC_1322 1348-1070 12 µM -1.11902224059412 0.185541659613877 no 2774 0.131565325483826 938 6758089
SGTC_875 0709-0210 25.7 µM -1.11929445554758 0.18548364015492 no 2775 0.13150727019641 966 6251364
SGTC_3265 9137266 49.47 µM -1.11977841848477 0.185380516880577 no 2776 0.131404099085576 925 17224265
SGTC_3284 9108171 64.8615 µM -1.12877589506174 0.183469812735751 no 2777 0.129496191851575 937 8687505
SGTC_1742 st038235 28.8875 µM -1.12895363589161 0.183432191761373 no 2778 0.129458696381973 957 564103 YBR002C RER2
SGTC_2521 angolensin 13.4 µM -1.12899682674855 0.183423050625791 no 2779 0.129449586153792 952 821428 A flavenoid.
SGTC_992 3909-8734 162 µM -1.129736157182 0.183266618961276 no 2780 0.129293708396428 977 4288319
SGTC_1699 st031318 29.054 µM -1.13387943456911 0.182391501516588 no 2781 0.128422562369257 953 5340658
SGTC_183 3914-0051 30.55 µM -1.13572296845958 0.18200296234467 no 2782 0.128036262386385 960 1596232
SGTC_3250 9135583 49.47 µM -1.13674377261882 0.18178804268497 no 2783 0.127822707403554 964 7699353
SGTC_2804 7954240 19.48 µM -1.13679204602526 0.181777883156098 no 2784 0.127812614610149 947 828705
SGTC_230 MPP+ 141.667 µM -1.13891547905399 0.18133134098638 no 2785 0.127369204392492 974 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_1345 1488-0192 31.4 µM -1.13897674456167 0.181318467508846 no 2786 0.127356426975079 962 658348
SGTC_3264 9137442 49.47 µM -1.13924726495515 0.181261630976923 no 2787 0.127300018417606 949 17015726
SGTC_3034 9090421 49.47 µM -1.13980630057769 0.181144212542165 no 2788 0.127183504116358 942 17173761
SGTC_380 3970-0968 6 µM -1.13990861969628 0.181122726851543 no 2789 0.127162186783413 954 2891601
SGTC_3144 9087057 49.47 µM -1.14228999263696 0.180623120382499 no 2790 0.126666749788516 954 17249618
SGTC_1392 3455-1037 33.9 µM -1.14299107145853 0.18047620050612 no 2791 0.126521149065336 940 981132
SGTC_1390 3413-2614 145 µM -1.14378759074076 0.180309370877159 no 2792 0.12635586869741 982 3421432
SGTC_1741 st038134 10.228 µM -1.1454112195653 0.179969604332776 no 2793 0.126019426438912 978 1272587
SGTC_259 usnic acid 108.925 µM -1.14593127233726 0.179860861242174 no 2794 0.12591179525066 994 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_2457 5731572 11.68 µM -1.14841179544645 0.179342751652782 no 2795 0.12539930328621 959 2865357
SGTC_1085 doxorubicin 7.67 µM -1.14881473644923 0.179258677611596 no 2796 0.125316190761607 952 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1957 st077035 62.4 µM -1.15633191520796 0.177694757563584 no 2797 0.123772709373161 979 705593
SGTC_2646 retinol 96.75 µM -1.15732661466848 0.177488461027021 no 2798 0.123569471892974 940 445354 A vitamin A analog and teratogen.
SGTC_2551 apiole 73.87 µM -1.15887754447561 0.177167106384866 no 2799 0.123253051656215 952 10659 A possible DNA adduct former.
SGTC_55 0767-0285 6.563 µM -1.15982565844173 0.176970837077698 no 2800 0.123059897593237 958 3116166
SGTC_1503 4585-0012 61.3 µM -1.16204241948281 0.176512481229259 no 2801 0.122609117313763 974 2922052
SGTC_3215 9129942 49.47 µM -1.16362979409167 0.176184724304457 no 2802 0.1222870359039 980 17682944
SGTC_865 0488-0499 301 µM -1.16430580333136 0.176045260725578 no 2803 0.122150052784872 945 9634651
SGTC_2194 5927483 104.545 µM -1.1671753494016 0.17545403949628 no 2804 0.121569781819094 955 760979
SGTC_2399 5884133 200 µM -1.17119835808251 0.174627288733779 no 2805 0.120759527563207 977 722445
SGTC_636 0kpi-0074 126 µM -1.17226204322729 0.174409109642337 no 2806 0.120545932848614 976 616434
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -1.17243452729648 0.17437374668317 no 2807 0.120511322037403 970 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_1303 1160-0052 261 µM -1.17313766967037 0.174229634450368 no 2808 0.120370301257777 941 3562476
SGTC_2906 7926292 26.41 µM -1.17372508230736 0.174109299598681 no 2809 0.120252580141347 983 2966319
SGTC_2340 7987427 183.45 µM -1.17507715288744 0.173832520976889 no 2810 0.119981925137151 957 2239331
SGTC_3316 9136639 10.545 µM -1.17527313477846 0.173792425300409 no 2811 0.11994272950091 948 4903665
SGTC_1966 st070145 16.1 µM -1.17733891909665 0.173370147057771 no 2812 0.119530129398475 977 3748532
SGTC_403 arphamenine a 50 µM -1.17905130587759 0.173020604300709 no 2813 0.119188873337545 978 5487158 An arginine aminopeptidase inhibitor.
SGTC_1715 st032160 10.2275 µM -1.17987540673869 0.17285254398224 no 2814 0.119024886281183 964 5289825
SGTC_750 4073-0104 132 µM -1.18134518301413 0.172553068276922 no 2815 0.11873281244245 913 22330957
SGTC_1107 amlodipine 47 µM -1.1857253219502 0.171662552423814 no 2816 0.117865395586748 873 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_2470 5664817 21.68 µM -1.18590446321185 0.171626194233947 no 2817 0.117830015198814 988 2859561
SGTC_1973 st070275 50.2 µM -1.18607786109302 0.171591006396441 no 2818 0.117795776286171 976 17118334
SGTC_2394 5221648 200 µM -1.18626787429081 0.171552452086657 no 2819 0.117758264620723 974 788586
SGTC_479 n-linoleoylglycine 10 µM -1.18767137215964 0.171267849159767 no 2820 0.117481453351769 988 6433346 An anti-infammatory.
SGTC_989 1501-0895 10.3 µM -1.19022990053517 0.170749805036589 no 2821 0.116978022035315 951 2830112
SGTC_3067 9117431 49.47 µM -1.19070190242108 0.170654345018679 no 2822 0.116885315411852 1005 17150885
SGTC_2078 5212016 200 µM -1.1935485782238 0.17007934363714 no 2823 0.116327299475252 970 1899708
SGTC_567 1080-0542 68.4 µM -1.19721806081605 0.169339977280142 no 2824 0.115610786027883 925 5950415
SGTC_27 0485-0001 32.618 µM -1.20080691943682 0.168618854560066 no 2825 0.11491305357503 936 2054479
SGTC_965 1291-5240 308 µM -1.20172647883168 0.168434402217883 no 2826 0.114734759324577 985 2834598
SGTC_2228 7354201 200 µM -1.20204118230385 0.168371306370585 no 2827 0.114673786398257 992 753451
SGTC_705 1124-0212 310 µM -1.20297809618233 0.168183551688946 no 2828 0.114492398443682 952 9554485
SGTC_3082 9117008 49.47 µM -1.20629489340536 0.167519958632633 no 2829 0.113851902981993 962 41448529
SGTC_811 0416-0114 265 µM -1.20688644676546 0.16740178378219 no 2830 0.113737938955477 954 6612453
SGTC_410 α-linolenic acid 100 µM -1.21156158341948 0.166469720390212 no 2831 0.11284012380573 975 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1910 st062352 60.4 µM -1.21541974789798 0.165703061726811 no 2832 0.112103019958405 976 2245730
SGTC_2249 haloperidol 116.36 µM -1.21553107810632 0.165680973161843 no 2833 0.112081801491937 953 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2844 9010103 25.97 µM -1.21604282121978 0.165579464823739 no 2834 0.111984305108326 985 2480525
SGTC_980 1473-0395 201 µM -1.21633544244099 0.165521439144088 no 2835 0.111928582693943 973 768876
SGTC_2154 5570129 200 µM -1.21692294948702 0.165404978440541 no 2836 0.111816766498323 1009 673366
SGTC_2116 5511452 16.8835 µM -1.21864478348791 0.165063967123959 no 2837 0.111489521855278 984 870744
SGTC_657 3534-0529 86.7 µM -1.22046398638471 0.164704166640089 no 2838 0.111144516892972 1010 1049549
SGTC_547 1120-0019 610 nM -1.22095379438225 0.164607379694348 no 2839 0.111051757418518 927 3676939
SGTC_368 fentichlor 4.58 µM -1.22132696058194 0.16453366611938 no 2840 0.110981124701226 1016 7329 A pesticide.
SGTC_2245 6637752 200 µM -1.22255712387241 0.164290816721866 no 2841 0.110748507889091 992 681890
SGTC_1549 4'-methoxyflavonol 74.6 µM -1.22462600013274 0.163882919448157 no 2842 0.110358083521488 981 97141
SGTC_522 1273-0010 11.6 µM -1.22604897525414 0.16360274908948 no 2843 0.110090122736681 940 5705015
SGTC_658 3253-0951 102 µM -1.22941457344955 0.162941333021103 no 2844 0.109458204478506 988 1184878
SGTC_2001 4023502 57.655 µM -1.23073337268204 0.162682633926586 no 2845 0.109211301010217 964 108941 YCR052W RSC6
SGTC_1226 3909-7979 35.4 µM -1.23200602502198 0.16243324058372 no 2846 0.108973416740834 976 6615510
SGTC_2193 5925765 200 µM -1.23605310629035 0.161641815230148 no 2847 0.108219412068319 978 877370
SGTC_768 0384-0033 77.3 µM -1.23859201508241 0.161146605132684 no 2848 0.107748313329742 960 3965305 YMR134W ERG29
SGTC_3255 9139072 49.47 µM -1.23927451677841 0.161013653262424 no 2849 0.10762192632441 976 17646060
SGTC_333 3486-0131 40.1 µM -1.24013420410885 0.16084628739837 no 2850 0.107462879796693 961 6744690
SGTC_1596 piperlongumine 63 µM -1.24103208673584 0.160671606889879 no 2851 0.107296947879076 969 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_2792 7535235 81.82 µM -1.24175825409259 0.160530423750056 no 2852 0.107162884723214 980 1281891
SGTC_713 1488-1073 324 µM -1.24246790289033 0.160392530509303 no 2853 0.107031987923421 995 3312542
SGTC_48 0382-0018 55 µM -1.24481860983111 0.159936313057921 no 2854 0.106599216929423 993 762596
SGTC_714 4296-0578 26.1 µM -1.24506170566919 0.159889182288974 no 2855 0.106554534549849 973 1589775
SGTC_1179 1021-1431 9.29 µM -1.24810355031961 0.159300205724216 no 2856 0.105996569146418 995 2840958
SGTC_2445 5742597 35.57 µM -1.2490823743541 0.159110983645684 no 2857 0.105817473288315 980 1774255
SGTC_566 0958-0068 16.5 µM -1.24944497216299 0.159040925177459 no 2858 0.105751184162908 965 6815365
SGTC_998 3996-0085 177 µM -1.2496354970963 0.159004121459327 no 2859 0.105716364956661 986 715391
SGTC_2604 4'-hydroxychalcone 11.32 µM -1.25188560046796 0.158569890950281 no 2860 0.105305776230275 998 5282362
SGTC_787 4152-0075 138 µM -1.25203243573612 0.158541581373012 no 2861 0.105279022548255 965 9566539
SGTC_341 1486-1430 230 µM -1.25250947945944 0.158449631074337 no 2862 0.105192138161555 991 2054753 YPL210C SRP72
SGTC_2808 7946468 45.46 µM -1.2566610699463 0.157650888144349 no 2863 0.104438195316439 994 2970879
SGTC_711 k292-0785 179 µM -1.2576132465199 0.157468068236534 no 2864 0.104265830188181 963 4146315
SGTC_1540 guanosine 70.6 µM -1.25773001186612 0.157445658638753 no 2865 0.104244707265439 971 6802 Guanosine is a purine nucleoside
SGTC_675 1309-0189 238 µM -1.25773088809954 0.157445490480015 no 2866 0.104244548766002 976 4246530
SGTC_3098 9119039 49.47 µM -1.25860320099043 0.157278142685893 no 2867 0.104086845136541 975 17161528
SGTC_1321 1326-2144 215 µM -1.25977026081503 0.157054432484253 no 2868 0.103876125443152 1004 3513030
SGTC_2006 4011487 200 µM -1.25994652247339 0.157020663615796 no 2869 0.10384432724996 980 45595294
SGTC_2547 epiafzelechin trimethyl ether 100 µM -1.26010204185869 0.156990872595984 no 2870 0.103816276895748 949 6708630 An antioxidant.
SGTC_244 nsc-207895 1.295 µM -1.26053393925212 0.156908158593103 no 2871 0.10373840627061 951 42640
SGTC_1320 1313-0481 95.3 µM -1.26107639663816 0.156804311533251 no 2872 0.103640661845071 978 6813365 YLR208W SEC13
SGTC_662 k832-1615 104 µM -1.26234037085531 0.156562514108204 no 2873 0.10341316789156 990 5878478
SGTC_1937 st074714 47.2 µM -1.26588009247953 0.155886674727251 no 2874 0.102778007338825 986 17250970
SGTC_2459 5811157 9.22 µM -1.2665766992767 0.155753898354785 no 2875 0.102653344173933 983 2870684 YBR192W RIM2
SGTC_1876 myriocin 605 nM -1.2743177074877 0.154283447543206 no 2876 0.101275421728392 979 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_2536 dehydroabietamide 32.04 µM -1.27529273251195 0.154098888819595 no 2877 0.101102824546062 983 3983547
SGTC_3260 9137109 49.47 µM -1.27771422293532 0.153641166254128 no 2878 0.100675104209287 972 17478346
SGTC_245 methotrexate 289.6 µM -1.2814860602031 0.152929989134186 no 2879 0.100011496560711 971 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_1561 5-methoxyflavone 52.9 µM -1.28183692094445 0.152863945738368 no 2880 0.0999499297598411 961 94525
SGTC_2907 7721985 69.9 µM -1.28193884669163 0.152844763545431 no 2881 0.09993204967038 986 3267881
SGTC_1720 st037298 9.481 µM -1.28325482926935 0.152597241981753 no 2882 0.0997014062087722 999 597396
SGTC_3048 9093155 49.47 µM -1.28593492218788 0.152093969314104 no 2883 0.0992328873248757 964 25236002
SGTC_2000 st075254 36.4 µM -1.28981060306539 0.151368138672151 no 2884 0.0985582127999261 973 17234175
SGTC_2231 micatex 6.853 µM -1.29313590883205 0.150747220362163 no 2885 0.0979820287747253 1004 20737 An antifungal of unknown mechanism.
SGTC_2707 st078556 66.6 µM -1.293528387999 0.150674046671744 no 2886 0.097914186134712 964 17250899
SGTC_1395 3486-0190 4.35 µM -1.29457044560839 0.15047988056929 no 2887 0.0977342265927302 1002 6748079
SGTC_1336 1486-0901 104 µM -1.29647706347209 0.150125053027747 no 2888 0.0974055885833183 983 5006114
SGTC_1332 1480-0653 17.5 µM -1.29845511408395 0.149757521568886 no 2889 0.0970654954329717 993 5749438
SGTC_3300 9124615 50.48 µM -1.29859068740104 0.149732353382934 no 2890 0.0970422177943255 989 24824903
SGTC_1485 3909-9022 254 µM -1.29949715286546 0.149564147267286 no 2891 0.0968866849590178 1017 714516
SGTC_3007 9078383 71.4286 µM -1.3008047378475 0.149321730585124 no 2892 0.0966626499196715 998 6496995
SGTC_930 2810-3379 265 µM -1.30614659918081 0.148334114742849 no 2893 0.0957513543187326 1017 1015764
SGTC_1275 0867-0008 21.1 µM -1.30795501325086 0.148000763138171 no 2894 0.0954442841776467 1000 3422836
SGTC_2640 pentamidine 10.38 µM -1.31030904784811 0.147567587022038 no 2895 0.0950456539338955 949 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_553 k007-0256 45.7 µM -1.31162781579733 0.147325286351935 no 2896 0.0948228715112058 1010 6287000
SGTC_1623 st003709 20.3 µM -1.31258479299682 0.147149625476678 no 2897 0.094661448295752 982 16192618
SGTC_1513 0337-0559 19 µM -1.31973628777198 0.14584135751911 no 2898 0.0934615399953332 999 775073
SGTC_3179 9107801 49.47 µM -1.32005040743648 0.145784073414352 no 2899 0.0934090944050948 975 4818259
SGTC_1227 3909-8010 46.6 µM -1.32029048492444 0.145740302131747 no 2900 0.0933690255960305 995 15982272
SGTC_3333 9141820 12.094 µM -1.32174506954789 0.14547528903871 no 2901 0.0931265276585086 983 1939433
SGTC_1572 epiandrosterone 68.9 µM -1.32456135824064 0.144963106647308 no 2902 0.0926583397487395 992 441302 A steroid.
SGTC_3084 9116877 49.47 µM -1.3249227061254 0.144897478344731 no 2903 0.0925983944829531 986 27241325
SGTC_847 0342-0274 5.54 µM -1.32921978957053 0.144118571934655 no 2904 0.091887733991735 999 18097
SGTC_731 3966-0296 387 µM -1.32955489767544 0.144057947802781 no 2905 0.0918324833863976 1000 660956
SGTC_783 0848-0141 92.7 µM -1.34140566521344 0.141925090141354 no 2906 0.0898943896165625 995 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_3068 9116768 49.47 µM -1.34208688457409 0.141803140012743 no 2907 0.0897839129519201 998 41904888
SGTC_3194 9111903 49.47 µM -1.34373719224158 0.141508000470268 no 2908 0.0895166929754322 1010 17087251
SGTC_1607 st000305 50.6 µM -1.34506930844034 0.141270069806986 no 2909 0.089301426741306 998 5457690
SGTC_2259 7964009 200 µM -1.34511972450028 0.141261070271298 no 2910 0.0892932872180375 985 313134
SGTC_536 3852-0578 10.6 µM -1.34586712951696 0.141127700076715 no 2911 0.0891726856321974 1011 2869208
SGTC_2514 salinomycin 42.74 µM -1.34642337448559 0.141028496747563 no 2912 0.0890830084151904 1011 23682228 A polyether potassium ionophore.
SGTC_1127 asiatic acid 681.4 nM -1.34903139766245 0.140564000495346 no 2913 0.0886634406904652 996 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_412 gemfibrozil 100 µM -1.34937341466664 0.140503163418306 no 2914 0.0886085277868139 994 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_1529 apigenin 74 µM -1.34966437032672 0.140451423071141 no 2915 0.088561833037042 992 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -1.35113548489296 0.140190014345892 no 2916 0.0883260181407265 1008 364106
SGTC_1180 1193-0155 285 µM -1.35238747774291 0.13996780278401 no 2917 0.0881256965937561 1016 2921347
SGTC_207 4185-0010 4.486 µM -1.35322556708202 0.139819187230034 no 2918 0.0879917898718664 988 3761753
SGTC_1714 st033236 13.627 µM -1.35332319315963 0.139801882504802 no 2919 0.0879762014205548 998 2916566
SGTC_2644 guaiazulene 100 µM -1.35430593746355 0.139627767105529 no 2920 0.0878193963367038 981 3515 A coloring agent.
SGTC_1328 1441-0025 69.2 µM -1.35621553282233 0.139289860854605 no 2921 0.0875153006507305 991 4562601
SGTC_2372 9071633 200 µM -1.36061893165386 0.138512793955629 no 2922 0.0868170728268692 1011 21321366
SGTC_609 0986-0026 86.3 µM -1.36202788536416 0.138264781175464 no 2923 0.0865945424795888 981 2848610
SGTC_1583 clindamycin 39.6 µM -1.36609731356154 0.137550155836176 no 2924 0.0859542106987688 1015 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_2858 9025781 8.96 µM -1.36958962956801 0.136938889875983 no 2925 0.0854075193204678 966 4894980 YPL153C RAD53
SGTC_854 0422-0053 192 µM -1.37148413200973 0.136608069761897 no 2926 0.0851120433702905 1012 3596728
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -1.37180416269266 0.136552239652891 no 2927 0.0850622055314091 1000 6857784
SGTC_2416 tofa 880 nM -1.37644471186655 0.135744438365899 no 2928 0.0843419966565794 1002 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1971 st069429 63.5 µM -1.38030759856636 0.135074509293427 no 2929 0.083745978192651 991 1246522 YGL099W LSG1
SGTC_3349 9149703 23.001 µM -1.38192403036351 0.134794850296594 no 2930 0.0834975143025014 1013 4910494
SGTC_1444 4112-3581 28 µM -1.38202984557142 0.134776557063276 no 2931 0.0834812686458533 997 2877249
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -1.38204075383766 0.134774671349357 no 2932 0.0834795940505029 1018 6708784 An antioxidant flavonoid
SGTC_59 0330-0160 1.33 µM -1.38234325583502 0.13472238498734 no 2933 0.0834331651564806 1002 4293482
SGTC_462 ag-879 158 µM -1.38393777673644 0.134447007965305 no 2934 0.0831887541369339 1010 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_689 0833-0039 98 µM -1.38494123180818 0.134273907479572 no 2935 0.083035218987027 1010 5374726
SGTC_651 3253-0966 34.4 µM -1.3862645474853 0.134045863721603 no 2936 0.0828330690685689 1017 781462
SGTC_3073 9114972 49.47 µM -1.38786886471363 0.133769752696354 no 2937 0.0825884901372137 1001 41905075
SGTC_1980 st071811 45.7 µM -1.3945024832957 0.132632225705011 no 2938 0.0815829600659536 1010 4974850
SGTC_275 trichlorophene 5.69 µM -1.39606111935578 0.132365921788956 no 2939 0.0813480454040345 978 62616
SGTC_2261 9010538 184.68 µM -1.39637932879647 0.132311598800477 no 2940 0.081300148263874 1015 6457250
SGTC_435 c-PAF 6.7 µM -1.39770174403875 0.132086007886746 no 2941 0.0811013251650766 994 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_2374 9071832 200 µM -1.40030215640236 0.131643177254276 no 2942 0.0807114276896838 999 17381698
SGTC_1192 1488-0095 21.4 µM -1.40100512131477 0.131523643750389 no 2943 0.0806062708278152 1025 915875
SGTC_1887 st057648 70.8 µM -1.40445517338115 0.130938076547718 no 2944 0.0800916756056833 1004 688672
SGTC_543 3844-1095 191 µM -1.40631873189011 0.130622530692384 no 2945 0.0798147501158154 1002 4230703
SGTC_2197 6588183 93.1375 µM -1.40765863684831 0.130395977309118 no 2946 0.0796160877112144 1001 884136
SGTC_3150 9097574 49.47 µM -1.41099971670152 0.129832246209932 no 2947 0.079122348776971 1002 17217476
SGTC_395 anisomycin 6.25 µM -1.41184769552169 0.129689438003148 no 2948 0.0789974056416093 1014 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_2118 5526350 200 µM -1.41375417635595 0.129368764717066 no 2949 0.0787170461434208 1011 743594
SGTC_2352 9027995 87.8 µM -1.4142859024057 0.129279425581044 no 2950 0.0786389872523669 999 2997347
SGTC_1234 0326-0494 15.5 µM -1.41561478618414 0.129056337223123 no 2951 0.0784441598780411 1006 1547813
SGTC_2051 5263410 176 µM -1.41652160902774 0.128904256290476 no 2952 0.0783114209780329 1010 227584
SGTC_2774 tamoxifen 10.92 µM -1.41773821079387 0.128700418440856 no 2953 0.078133604899084 999 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_1794 st048918 76.9 µM -1.42253764672353 0.127898469790272 no 2954 0.077435115326932 945 672303
SGTC_585 0kpi-0023 191 µM -1.42276724837578 0.127860192349539 no 2955 0.0774018193247078 998 64601
SGTC_1704 st028805 70.8 µM -1.42303051683881 0.127816312032207 no 2956 0.07736365446695 1007 2876101
SGTC_1785 bathophenanthroline 24 µM -1.42461259344664 0.127552839554181 no 2957 0.0771346088383325 957 72812 An iron chelator.
SGTC_223 busulfan 5 mM -1.42629408570467 0.127273225020626 no 2958 0.076891735539429 1010 2478 A DNA alkylator.
SGTC_632 0781-2353 4.65 µM -1.42798586797905 0.126992329976052 no 2959 0.0766479630948106 1034 6811515 YHR007C ERG11
SGTC_2989 9073649 71.4286 µM -1.42878095014309 0.126860467672008 no 2960 0.0765336012644173 1008 21367202
SGTC_2898 9056270 58.44 µM -1.42879759406678 0.126857708339604 no 2961 0.0765312086485301 969 19154699
SGTC_489 paxilline 115 µM -1.43183654170328 0.126354592984947 no 2962 0.076095303367613 1018 105008 A toxic potassium channel blocker.
SGTC_285 1486-1325 46 µM -1.43477305633288 0.125869758477738 no 2963 0.0756758890823336 1007 22310230
SGTC_1448 4255-0083 152 µM -1.43577895979357 0.125703977088483 no 2964 0.0755326243370312 1027 5399660
SGTC_2202 7226349 200 µM -1.43655084025087 0.125576868001731 no 2965 0.0754228302831929 1013 844334
SGTC_1033 k072-0102 21.3 µM -1.43806710658042 0.1253274386854 no 2966 0.0752075072767519 996 5965931
SGTC_1481 3346-2004 36 µM -1.44181218684214 0.124712847098692 no 2967 0.0746776819773468 1032 2770522
SGTC_3195 9113082 49.47 µM -1.45409422151514 0.122712080123137 no 2968 0.0729600927128717 1034 17018038
SGTC_1459 k035-0031 35.7 µM -1.45442022369297 0.122659282247174 no 2969 0.0729149181798736 977 3877128 YMR208W ERG12
SGTC_2721 ifenprodil 61.44 µM -1.45762839894567 0.122140550275276 no 2970 0.0724714987364741 1019 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_2480 5767542 37.17 µM -1.45922885279778 0.121882348514075 no 2971 0.0722510650111528 999 2867358
SGTC_3083 9117465 49.47 µM -1.46285233486909 0.12129918833117 no 2972 0.071753894514069 1032 16420915
SGTC_1831 st055328 12 µM -1.46323402323868 0.121237874142629 no 2973 0.0717016769825642 1014 1103068
SGTC_686 1319-0111 510 µM -1.46431623988956 0.12106414604118 no 2974 0.0715537809748969 1022 4562600
SGTC_649 1123-0311 367 µM -1.46949556288243 0.120235134905594 no 2975 0.0708492122183597 1004 693629 YIL048W NEO1
SGTC_261 5-fluorouridine 15.376 µM -1.47225174755565 0.119795609522417 no 2976 0.0704764540683931 1020 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_889 0919-1524 82.7 µM -1.47738262466335 0.118980415023874 no 2977 0.0697865505294078 1012 3905452
SGTC_2938 9059746 27.26 µM -1.47773748713957 0.118924179602412 no 2978 0.0697390281884179 1021 6471769
SGTC_2649 anisomycin 9.56 µM -1.47849135899921 0.11880477505521 no 2979 0.0696381541315386 1026 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_762 1165-0429 115 µM -1.48284656071549 0.118116619409545 no 2980 0.0690575911263307 1009 5967793
SGTC_2839 9003951 25.97 µM -1.48865235740249 0.117203649206986 no 2981 0.0682894683684962 995 2990634
SGTC_706 4262-0057 46.9 µM -1.49017888568699 0.116964432537089 no 2982 0.0680886032803938 1034 883298
SGTC_2273 7815444 169.05 µM -1.49397545638168 0.116370986816378 no 2983 0.0675910172084231 1019 2824616
SGTC_3303 9125618 40.5795 µM -1.4955888305844 0.11611944654303 no 2984 0.0673804177947919 1002 22695467
SGTC_2634 4'-methoxyflavone 100 µM -1.50067011812126 0.115329748227734 no 2985 0.0667204527935722 1023 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_1189 1431-2119 7.28 µM -1.50169839633709 0.115170405879587 no 2986 0.0665875091265452 1022 3107275
SGTC_902 1120-0002 2.07 µM -1.50456275960397 0.114727368594233 no 2987 0.0662182633478838 968 3280475
SGTC_3209 9113616 49.47 µM -1.50569860106562 0.114552021729791 no 2988 0.0660722816315159 1020 16649353
SGTC_2588 indole-3-carbinol 100 µM -1.50747347073564 0.114278406179955 no 2989 0.0658446694629434 1015 3712 Induces cell cycle arrest.
SGTC_1775 st081588 35.1725 µM -1.50844495915603 0.114128837859662 no 2990 0.065720341819175 1001 1426443 YGL099W LSG1
SGTC_2299 7976368 114.88 µM -1.5090925889435 0.114029207625152 no 2991 0.0656375616028314 1015 2979718
SGTC_158 k038-0087 26.446 µM -1.50986735214321 0.113910100827293 no 2992 0.0655386373888207 997 X158
SGTC_2487 5918373 44.05 µM -1.51011894781926 0.113871441303029 no 2993 0.0655065377379894 1034 2876279
SGTC_1663 st014140 55.4 µM -1.51058574820979 0.113799738761222 no 2994 0.0654470136477926 1012 4207120
SGTC_571 k831-0106 44.2 µM -1.51342435911948 0.113364408697419 no 2995 0.0650859506859556 1012 4783639
SGTC_2465 5809242 33.21 µM -1.52028026422822 0.112317887547766 no 2996 0.0642202760176279 1053 2731748
SGTC_253 dyclonine 31.25 µM -1.52405865095759 0.111744094303946 no 2997 0.0637470303063707 1030 3180 An oral anasthetic.
SGTC_1548 st061468 90.8 µM -1.5279267341906 0.111158854745512 no 2998 0.0632653648395205 1044 390799
SGTC_2941 9056145 11.23 µM -1.53131901397347 0.11064741324383 no 2999 0.0628452842732265 1014 2119517
SGTC_2216 7189485 200 µM -1.53196329438699 0.11055046833903 no 3000 0.0627657464053667 1018 731273
SGTC_1349 flufenamic acid 69 µM -1.53437513902028 0.110188098567823 no 3001 0.0624686950574889 1032 3371 A non-steroidal anti-inflammatory.
SGTC_20 0481-0013 4.944 µM -1.53803466270904 0.109639898510242 no 3002 0.0620200698754842 1014 182045
SGTC_721 1187-1332 279 µM -1.54010828727316 0.109330138141965 no 3003 0.0617669800260795 1038 25730
SGTC_2582 agaric acid 100 µM -1.54236415420338 0.108993868740788 no 3004 0.0614925635767956 1009 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_1832 st054113 55 µM -1.55041558772477 0.107799749863422 no 3005 0.0605208997960225 1024 1251267
SGTC_1813 st051246 8.6015 µM -1.55635149833202 0.106925441770158 no 3006 0.059812265882852 1024 5291959
SGTC_1670 st016595 4.04 µM -1.5566600928056 0.10688012878009 no 3007 0.0597756041188791 1053 597879
SGTC_818 4072-2707 53.5 µM -1.55942797513478 0.106474321417293 no 3008 0.0594475596676372 1016 882871
SGTC_2133 5320837 200 µM -1.5648523019516 0.105682273551045 no 3009 0.0588087724488658 1043 2841355
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -1.56600642627433 0.105514301961583 no 3010 0.0586735563577635 1039 521171
SGTC_2734 clemastine 41.6 µM -1.56647856344646 0.10544564265835 no 3011 0.0586183116103621 1064 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_453 enantio-paf c16 10 µM -1.56923895413239 0.105044866831919 no 3012 0.0582961353179908 1016 13871343 A lipid and platelet activating factor
SGTC_540 1187-0821 17.3 µM -1.56983344748321 0.104958697967531 no 3013 0.058226931981468 1028 847520
SGTC_562 3772-2733 112 µM -1.57493367769497 0.104221546785638 no 3014 0.0576358770345083 1028 2876874 YIL048W NEO1
SGTC_1567 st069303 68.4 µM -1.57591276101301 0.104080467410415 no 3015 0.0575229548317884 1026 5581319
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -1.5801321602779 0.103474064188921 no 3016 0.0570383018314491 1036 551469
SGTC_1021 4476-0760 85.3 µM -1.58045269438346 0.103428102719109 no 3017 0.0570016160930676 1042 746768
SGTC_43 0570-0105 72.5 µM -1.58050233233482 0.103420986445505 no 3018 0.0569959365966426 1020 1114046 YDL195W SEC31
SGTC_1292 0kpi-0043 232 µM -1.58099764337763 0.103349996355744 no 3019 0.0569392882866494 1036 3333905
SGTC_1439 4092-1168 46 µM -1.58161628149977 0.10326138019608 no 3020 0.056868597438319 1049 2886240
SGTC_2759 disulfiram 3.38 µM -1.58188350755348 0.103223118751488 no 3021 0.0568380833023642 1008 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1829 berberine 14.4 µM -1.58271068801933 0.103104748249146 no 3022 0.0567437105543173 979 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2676 harmalol 100 µM -1.58299605272478 0.103063935103004 no 3023 0.0567111820387646 1021 5459187 A monoamine oxidase inhibitor
SGTC_786 4544-0069 423 µM -1.5837139995327 0.102961305532042 no 3024 0.0566294087691889 1019 748821 YLR208W SEC13
SGTC_406 estrone 100 µM -1.58837992062062 0.102296126833442 no 3025 0.0561002275714167 1022 5870 A steroid.
SGTC_1825 st052143 62.6 µM -1.59164389807218 0.101832672266998 no 3026 0.0557323702987077 1043 674173
SGTC_3015 9080845 49.47 µM -1.59753563168601 0.100999973461781 no 3027 0.0550731808290547 1044 5296973
SGTC_408 cantharidin 100 µM -1.59910647100379 0.100778801822672 no 3028 0.0548984735490288 1032 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2783 7738165 71.43 µM -1.59983982628804 0.100675667602259 no 3029 0.0548170605780954 1027 17201110
SGTC_2353 9059630 146.67 µM -1.60619307109554 0.0997854101786785 no 3030 0.0541157476471055 1049 4779114
SGTC_131 0141-0277 33.849 µM -1.60988082305571 0.0992713038150271 no 3031 0.0537119381276475 1048 1547771
SGTC_1517 deoxycholic acid methyl ester 49.2 µM -1.61452307064877 0.0986268889286576 no 3032 0.053207008399684 1035 229346 A bile salt which induces apoptosis.
SGTC_2179 6298986 200 µM -1.61864094868408 0.0980578319726034 no 3033 0.0527622695837446 989 738374
SGTC_2367 9070478 135.38 µM -1.61892930718604 0.0980180735121696 no 3034 0.0527312371368328 1025 572802
SGTC_1188 1403-0014 4.57 µM -1.62198675159354 0.0975972438427588 no 3035 0.052403092435852 1018 9614867
SGTC_1795 st049545 62.3 µM -1.62562095514044 0.0970987537195878 no 3036 0.0520151573001604 1011 5291882
SGTC_2239 6685329 187.64 µM -1.62806991260621 0.0967638948884735 no 3037 0.0517550311947557 1007 805680
SGTC_216 k038-0035 28.382 µM -1.6285813195684 0.0966940746931067 no 3038 0.0517008407278551 1039 4444231 YPR107C YTH1
SGTC_2976 9009005 19.48 µM -1.64064222852307 0.0950581613856062 no 3039 0.050435851846854 1023 2993148
SGTC_924 2046-0044 21.3 µM -1.64191867626665 0.0948862271688697 no 3040 0.0503034294064429 1032 3623589
SGTC_2628 lathosterol 100 µM -1.64255708943973 0.0948003205672147 no 3041 0.0502373025777998 1035 6710616
SGTC_1477 0139-0234 16 µM -1.64525903409544 0.0944373741375396 no 3042 0.0499582020134768 1047 620880
SGTC_665 3914-0008 307 µM -1.64584115022924 0.0943593140531422 no 3043 0.0498982338442577 1046 1069549
SGTC_1492 4158-0558 28.5 µM -1.64845225934111 0.0940097572556142 no 3044 0.0496299498292023 1011 3967268
SGTC_1563 conessine 56.1 µM -1.65189305209169 0.0935505887538327 no 3045 0.0492781773521828 1048 441082 An anti-amoebic, histamine inhibitor.
SGTC_1969 st069479 40.1 µM -1.65761433889277 0.0927907618452318 no 3046 0.0486976668077191 1040 3895485
SGTC_1469 k284-2957 126 µM -1.6596999239622 0.0925149195866958 no 3047 0.0484874173440236 992 23884841
SGTC_1391 3442-0225 151 µM -1.66281744948624 0.0921037233983914 no 3048 0.0481744913154468 1042 5227075
SGTC_21 0849-0113 22.993 µM -1.66355118606559 0.0920071418282291 no 3049 0.0481010768825725 1047 1560156
SGTC_2100 5377183 190 µM -1.66423998233076 0.0919165440046765 no 3050 0.0480322404756701 1009 2844202
SGTC_2537 larixol 68.93 µM -1.66576685568114 0.0917159489395337 no 3051 0.0478799300354491 1035 6708759
SGTC_507 nimesulide 162 µM -1.66948859634382 0.0912283592440166 no 3052 0.047510294257724 1043 4495 A COX2 inhibitor.
SGTC_810 3825-7150 143 µM -1.669940574972 0.0911692761140194 no 3053 0.0474655607435204 1007 22330411 YGL099W LSG1
SGTC_348 k064-0012 10.7 µM -1.68028322432086 0.0898250171502857 no 3054 0.046451111713406 1028 5066323
SGTC_28 pentachloropyridine N-oxide 1.606 µM -1.68801721852197 0.0888294793870236 no 3055 0.0457039618527283 1049 140250 A respiratory chain inhibitor.
SGTC_1873 rapamycin 2 nM -1.69361637630003 0.0881138859351042 no 3056 0.0451691020602554 1018 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_1756 st041558 35.5 µM -1.69626702681265 0.0877766254451711 no 3057 0.0449176609785458 1044 3955792
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -1.6967568313434 0.0877144097954927 no 3058 0.0448713216273708 1049 6710655
SGTC_831 k061-1017 217 µM -1.69703912422136 0.0876785675106706 no 3059 0.0448446319945579 1063 1240153
SGTC_842 0271-0008 11.1 µM -1.69710583341028 0.0876700991457988 no 3060 0.0448383267820321 1029 1221709
SGTC_2368 9071271 200 µM -1.69733747297563 0.0876406985145426 no 3061 0.0448164382386456 1044 27209959
SGTC_2927 9011802 47.9 µM -1.69924485246616 0.0873988858210365 no 3062 0.0446365292867282 1041 43912568
SGTC_2183 6420625 130.508 µM -1.70378539759502 0.0868252515263211 no 3063 0.044210593503768 1033 2897619
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -1.7081793807683 0.086272816199486 no 3064 0.0438015316112764 1034 6708760
SGTC_1100 amiodarone 5.07 µM -1.71052047789597 0.0859795563387739 no 3065 0.0435848349997577 1036 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_2256 7954252 200 µM -1.71144443638233 0.0858640212757515 no 3066 0.0434995500334974 1060 2972920
SGTC_2842 9000675 19.48 µM -1.71573082858841 0.0853295550392668 no 3067 0.0431056597734975 1026 2989072
SGTC_1383 3049-0032 20.7 µM -1.71985248201873 0.0848179840446175 no 3068 0.042729629956036 1035 712864
SGTC_1190 1486-1332 13 µM -1.73130656799939 0.08340840482077 no 3069 0.0416985503140618 1036 4150046
SGTC_682 0kpi-0099 17 µM -1.73211164066891 0.0833099960761107 no 3070 0.0416268434944804 1047 1714895 YML126C ERG13
SGTC_3004 9076122 71.4286 µM -1.73495442203588 0.082963204483951 no 3071 0.0413744392459515 1045 44782551
SGTC_2541 muurolladie-3-one 83.07 µM -1.73740226911215 0.0826654620522628 no 3072 0.0411580955087509 1013 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_372 0155-0182 15.9 µM -1.73864062445064 0.0825151420986858 no 3073 0.0410489980325713 919 771486
SGTC_570 0987-0065 62.6 µM -1.74524488926811 0.0817169449535913 no 3074 0.0404711252277268 1020 3104428
SGTC_2181 6316240 54.2555 µM -1.7489571300167 0.0812708431574816 no 3075 0.0401492150276336 1051 12779990
SGTC_379 3970-0972 5.9 µM -1.7491897236893 0.0812429535463341 no 3076 0.0401291149117193 1059 2898042 YBL034C STU1
SGTC_1371 2421-0008 32.7 µM -1.7561387107057 0.0804130479928818 no 3077 0.0395323633506782 1028 2827552
SGTC_474 dl-dihydrosphingosine 5 µM -1.7589252928196 0.080082056443202 no 3078 0.0392950992548576 1030 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_1116 jasmonic acid 1.58368 µM -1.76346139914273 0.0795454600145107 no 3079 0.0389113510761807 1043 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_455 paf C-16 10 µM -1.76375133931868 0.0795112544193667 no 3080 0.0388869266825157 1037 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_1212 0520-0165 585 µM -1.77003444195055 0.0787727388526241 no 3081 0.0383607016705187 1050 5403258
SGTC_3071 9117417 49.47 µM -1.77328054149369 0.0783932344986754 no 3082 0.0380911158762312 1038 45595590 YGL055W OLE1
SGTC_24 0417-1663 219 µM -1.77452420474492 0.0782482046001017 no 3083 0.0379882410130803 1071 4329390
SGTC_1807 st050092 58.9 µM -1.78174683167375 0.0774099570031969 no 3084 0.0373952630649771 1055 5008496
SGTC_3203 9113543 49.47 µM -1.78760936929802 0.0767345884019848 no 3085 0.0369195264052455 1035 17018012
SGTC_545 4218-0007 221 µM -1.7925008952854 0.0761745176962015 no 3086 0.0365263829494585 1054 2840508
SGTC_1773 st048542 73.5835 µM -1.7937503814474 0.0760319539618183 no 3087 0.0364265099364808 1056 3237138
SGTC_1220 1838-0075 193 µM -1.7988822618043 0.0754485470738683 no 3088 0.0360186535335143 1029 5529645
SGTC_1958 st076513 41.9 µM -1.79915344355729 0.0754178135216107 no 3089 0.035997205818194 1054 732122 YGL099W LSG1
SGTC_2501 sodium tetradecyl sulfate 13.37 µM -1.79983487254669 0.0753406279691015 no 3090 0.0359433578891033 1039 23665772 A membrane-active detergent.
SGTC_2206 7254556 146.969 µM -1.81149756835612 0.0740289092302502 no 3091 0.0350319325668609 1062 4398905
SGTC_823 0417-1665 178 µM -1.81213233372139 0.0739580201781656 no 3092 0.0349828756975262 1055 3429856
SGTC_1943 st076331 65.2 µM -1.81239078912217 0.0739291713711364 no 3093 0.0349629175264372 1067 24208415
SGTC_2113 5491891 107.031 µM -1.81362268942637 0.073791784743034 no 3094 0.0348679174105006 1043 789979
SGTC_2413 inermin 26.06 µM -1.81634588410995 0.0734887753462985 no 3095 0.0346586654285165 1020 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_2458 5808907 16.39 µM -1.81754149656048 0.0733560407228579 no 3096 0.034567120189926 1057 2731747
SGTC_481 bay k-8644 50 µM -1.81829507128147 0.0732724745516143 no 3097 0.0345095228574075 1054 2303 A calcium channel antagonist.
SGTC_1906 st060206 94.7 µM -1.81854910137561 0.0732443208079743 no 3098 0.0344901245702398 1033 5133468
SGTC_1558 st069300 45.6 µM -1.81953917456352 0.0731346715808152 no 3099 0.0344146059206087 1039 24208000
SGTC_1626 st003712 1.76 µM -1.82270827279743 0.072784542756869 no 3100 0.0341737933332152 1050 24207035
SGTC_3127 9126946 49.47 µM -1.82326443297301 0.0727232295777697 no 3101 0.0341316752064012 1035 27243249
SGTC_1057 3448-5381 134 µM -1.82570341138064 0.0724548144133904 no 3102 0.0339474745296039 999 5497911
SGTC_293 4049-0273 38.5 µM -1.82869475248236 0.072126647513237 no 3103 0.0337226745131846 1049 1380311
SGTC_755 1995-0008 37.3 µM -1.83230031626611 0.0717326126374625 no 3104 0.0334533450082721 1054 689533
SGTC_2813 7971799 71.43 µM -1.83260335453524 0.071699570400057 no 3105 0.0334307894683282 1050 2234054
SGTC_1662 st014054 52 µM -1.83599756406256 0.071330274950655 no 3106 0.0331790084605567 1068 2838777
SGTC_2436 5633522 8.09 µM -1.84072394225875 0.070818471736763 no 3107 0.0328310117485787 1057 5724242
SGTC_166 k072-0058 166.424 µM -1.84382399935656 0.0704843124795904 no 3108 0.0326043969751326 1036 5846229
SGTC_324 1315-0088 19.6 µM -1.84528590051718 0.0703271533979656 no 3109 0.0324979801993634 1053 6787421
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -1.84711304158712 0.0701311088631116 no 3110 0.0323653793708786 1054 688761
SGTC_2230 bromochlorosalicylanilide 954.5 nM -1.84746932011086 0.0700929307028911 no 3111 0.0323395753088849 1043 77254
SGTC_2825 7998094 58.44 µM -1.85282294531902 0.0695211692994563 no 3112 0.0319538701565002 1057 2987815
SGTC_1879 gemcitabine 100 µM -1.85604527834587 0.0691787630520748 no 3113 0.0317235522623539 1064 60750 A nucleoside analog which inhibits DNA replication.
SGTC_1404 3909-7820 48.3 µM -1.85698457928796 0.0690791975892682 no 3114 0.0316566740234498 1007 23741373
SGTC_2338 7999974 200 µM -1.86207967056268 0.068541043366515 no 3115 0.0312959305435994 1037 315925
SGTC_2071 5230951 39.92 µM -1.86231897613308 0.068515847148054 no 3116 0.0312790711230219 1069 1799272
SGTC_2937 9044753 11.33 µM -1.86403496421155 0.0683353819254463 no 3117 0.031158397219937 1031 6465530 YGL099W LSG1
SGTC_1472 k841-0093 193 µM -1.86689290059579 0.068035635914949 no 3118 0.0309582727407973 1064 X1472
SGTC_2143 5623677 140.463 µM -1.87499651903692 0.0671912314363265 no 3119 0.0303966012085294 1039 5375313
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -1.88635192402165 0.0660216495686705 no 3120 0.0296237732559278 1074 442882
SGTC_2651 TUB2.036 5 µM -1.88657996753786 0.0659983241944091 no 3121 0.029608421635077 1028 15992207 YFL037W TUB2
SGTC_258 haloperidol 50.781 µM -1.88694603179748 0.0659608947550066 no 3122 0.0295837924268885 1069 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_143 4032-1194 15.74 µM -1.88940171298127 0.0657102307202791 no 3123 0.0294190107718387 1059 1806963
SGTC_2944 9067346 25.62 µM -1.89393602740968 0.0652493312344909 no 3124 0.0291167508558885 1050 6473075
SGTC_1726 st035556 14.5795 µM -1.89495580618893 0.0651460200747406 no 3125 0.0290491284137126 1040 5919439
SGTC_1098 clofazimine 15.1 µM -1.89504766205078 0.0651367206292938 no 3126 0.0290430437813293 1056 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_2779 methotrexate 400 µM -1.90027305010096 0.0646093989167835 no 3127 0.0286986480580446 1026 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_1952 st077036 64.1 µM -1.90451520774304 0.0641837438459296 no 3128 0.0284215589853876 1043 2937007
SGTC_2781 5567276 71.43 µM -1.90612343467817 0.0640229465134171 no 3129 0.0283170964534612 1040 2853274
SGTC_170 4197-0004 226 µM -1.90632052321845 0.064003262331159 no 3130 0.0283043165560025 1053 218692
SGTC_1789 tunicamycin 25 nM -1.90849566391905 0.0637863329807639 no 3131 0.0281635915321941 1026 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_2404 5161160 200 µM -1.91266690280913 0.0633719308775395 no 3132 0.0278953544204597 1044 2831543
SGTC_2200 6600604 21.907 µM -1.91481281144679 0.0631595582173879 no 3133 0.0277581900204851 1070 2904777
SGTC_618 k072-0232 33.2 µM -1.91636154776647 0.0630066301366406 no 3134 0.0276595458426806 1031 5872756 YGL099W LSG1
SGTC_1152 3909-8331 15.9 µM -1.91771345657289 0.0628733734585562 no 3135 0.0275736772546367 1044 16001939
SGTC_3014 9081533 49.47 µM -1.91891513183431 0.0627551096204636 no 3136 0.0274975376410619 1061 21367265
SGTC_2752 diclazuril 33.15 µM -1.91931896699938 0.0627154047985509 no 3137 0.0274719895360059 1056 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_308 4092-1169 104 µM -1.92048492688489 0.0626008782073995 no 3138 0.0273983376434779 1059 2268590 YDL196W YDL196W
SGTC_3343 9148379 18.9835 µM -1.92069450246656 0.0625803099090273 no 3139 0.0273851165507038 1023 1955036
SGTC_2036 5160441 105 µM -1.92216698357817 0.0624359452432526 no 3140 0.0272923748935258 1036 134534 YIL048W NEO1
SGTC_2966 9084041 48.03 µM -1.92519412223757 0.0621399749536383 no 3141 0.0271025385827523 1058 17741380
SGTC_1222 0366-0074 1.18 µM -1.92563337463817 0.0620971193235913 no 3142 0.0270750841777292 1071 286520
SGTC_2042 p-Dimethylaminoacetophenone 200 µM -1.92783734451897 0.0618824371814905 no 3143 0.0269376805273037 1072 75037 A free radical scavenger.
SGTC_701 4424-0219 185 µM -1.93037987610104 0.0616354968334621 no 3144 0.0267798932571892 1064 2911779
SGTC_120 rhodamine 6G 52.259 µM -1.93044698989422 0.0616289889248783 no 3145 0.0267757387116701 1061 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_2880 9042983 58.44 µM -1.93301482917908 0.0613803927529462 no 3146 0.026617185518134 1072 6464714
SGTC_1283 0922-0125 16.4 µM -1.93780225961983 0.0609190072225622 no 3147 0.0263236759977562 1048 3360884
SGTC_1426 4048-4480 71.7 µM -1.9401875092632 0.0606901445908579 no 3148 0.0261784529806013 1069 14224343
SGTC_1407 3909-7909 12.3 µM -1.94081686473352 0.060629870747295 no 3149 0.0261402473319061 1031 4411780
SGTC_2799 7812892 81.82 µM -1.94523586774139 0.0602079772546915 no 3150 0.0258732983981397 1040 20205235
SGTC_2564 betulinic acid 100 µM -1.9452667211621 0.0602050396995902 no 3151 0.0258714426131271 1070 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_2645 abamectin 100 µM -1.94804987404842 0.0599405168667376 no 3152 0.0257044978832055 996 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_2887 9044784 58.44 µM -1.95301286321061 0.0594710728172337 no 3153 0.0254090355008735 1050 6465546
SGTC_2756 carbadox 75.1 µM -1.95609379292271 0.0591811037828117 no 3154 0.0252270531132491 1034 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_100 0086-0128 49.5915 µM -1.95814835303607 0.0589883510292177 no 3155 0.0251063036841322 1059 93297
SGTC_1851 st056236 18.9 µM -1.96596281850906 0.058259716944335 no 3156 0.0246514528629825 1054 5393171
SGTC_3118 9124250 49.47 µM -1.96617753320895 0.0582397968336792 no 3157 0.0246390533688778 1048 1504786
SGTC_1279 0874-0590 65.2 µM -1.96863861105714 0.0580118528206135 no 3158 0.0244973027068816 1066 3523074
SGTC_63 0099-0242 26.702 µM -1.9695299675556 0.0579294689186008 no 3159 0.0244461323933116 1065 3898502 YLR359W ADE13
SGTC_1379 2144-0755 36.5 µM -1.98257228735211 0.0567345166878806 no 3160 0.0237076127183669 1050 5392327
SGTC_3063 1327-0034 4 µM -1.98544029182012 0.0564743693129518 no 3161 0.0235477534661932 1050 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_2244 6635614 200 µM -1.98584032835417 0.0564381581233151 no 3162 0.0235255281136451 1072 836499
SGTC_278 4092-0821 23.9 µM -1.98651374423529 0.0563772420483508 no 3163 0.0234881541238433 1072 877900
SGTC_2618 avocadyne 43.43 µM -1.99378034089894 0.0557232098745823 no 3164 0.0230880324514658 1074 3015189
SGTC_827 3253-0474 693 µM -1.99516141203216 0.0555995859778322 no 3165 0.0230126390825681 1063 5402065
SGTC_1 0258-0098 57.368 µM -2.00163326902474 0.0550231520317247 no 3166 0.0226620940819327 1033 6790032 YDR047W HEM12
SGTC_779 1360-0071 233 µM -2.00384330625328 0.0548273940548434 no 3167 0.0225434240981483 1060 7566
SGTC_29 0299-0004 12.984 µM -2.00651974752082 0.0545910609893204 no 3168 0.0224004120046844 1067 16871 A napthoquinone isolated from Swertia calycina.
SGTC_1886 st057356 49.9 µM -2.00707914929614 0.0545417670505323 no 3169 0.022370617992272 1066 24207747
SGTC_3032 9089427 49.47 µM -2.00816507537833 0.0544461767991249 no 3170 0.0223128764562295 1018 17173707
SGTC_2710 st078562 53.7235 µM -2.01502768378276 0.053845146853008 no 3171 0.0219508742413919 1070 17250908
SGTC_908 3448-7491 47.7 µM -2.02075235133805 0.0533478078121562 no 3172 0.0216527037750323 1023 1203031
SGTC_724 3910-0327 137 µM -2.03096029720094 0.05247001790257 no 3173 0.0211295111402588 1069 2885483
SGTC_2429 5902844 64.44 µM -2.0322418744125 0.0523606287674114 no 3174 0.0210645878132079 1068 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_2991 9074669 71.4286 µM -2.03303692643842 0.0522928580911023 no 3175 0.0210243962285391 1048 17333109
SGTC_2471 5466956 24.79 µM -2.04535770473748 0.0512515063368987 no 3176 0.0204098027701662 1059 724419
SGTC_720 r052-1644 49.9 µM -2.05339984847721 0.0505807305682951 no 3177 0.0200169069979605 1071 1422863 YOR257W CDC31
SGTC_3190 9110366 49.47 µM -2.0574352095962 0.0502467956549114 no 3178 0.0198221906022773 1067 17123768
SGTC_696 1560-0013 611 µM -2.05872522343576 0.0501404156432359 no 3179 0.019760284248022 1069 1650269
SGTC_2948 9070189 9.45 µM -2.0624482816089 0.0498344031053067 no 3180 0.0195825383202993 1038 6473636 YDL196W YDL196W
SGTC_1465 k213-0056 144 µM -2.06290672893119 0.04979682478462 no 3181 0.0195607453458778 1042 24048857 YMR208W ERG12
SGTC_2442 5158906 48.48 µM -2.06459783127857 0.0496584028063075 no 3182 0.0194805343196017 1065 1893835
SGTC_2418 pentamidine 31.67 µM -2.06737724404996 0.0494315663922066 no 3183 0.019349310394353 1025 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1350 1495-0454 146 µM -2.07184054398953 0.0490690341666056 no 3184 0.0191401571158475 1067 1069057
SGTC_2336 9001819 198.65 µM -2.08771860367348 0.0477965239376118 no 3185 0.0184116128385069 1046 2989602
SGTC_1609 st001574 46.4 µM -2.09426741952246 0.0472794411523722 no 3186 0.018118082461983 1059 3960012
SGTC_127 0180-0333 59.125 µM -2.09727237932096 0.0470436802426544 no 3187 0.0179847352322355 1022 771601
SGTC_1855 st056195 39.6 µM -2.0986708244671 0.0469342839519721 no 3188 0.017922964132621 1038 4028379
SGTC_1453 4237-0541 195 µM -2.10096438062109 0.0467553075100504 no 3189 0.017822046564158 1050 739892
SGTC_3214 9129694 49.47 µM -2.11136247145192 0.0459507551454264 no 3190 0.0173705840919969 1070 17158655
SGTC_119 0121-0043 24.815 µM -2.11702515647487 0.0455173055039905 no 3191 0.0171288564114287 1059 1092378
SGTC_204 PMA1.184 62.41 µM -2.13565867444116 0.0441141687292973 no 3192 0.0163536225683859 1077 2252213 YGL008C PMA1
SGTC_2603 homopterocarpin 100 µM -2.13715386540739 0.0440031064665675 no 3193 0.0162927394984686 1061 101795 A weak amylase inhibitor.
SGTC_2044 5102272 200 µM -2.15422808158839 0.0427507624464351 no 3194 0.0156111448353806 1078 592666
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -2.1579673072158 0.0424803835250215 no 3195 0.0154651868548 1044 1377
SGTC_2225 6654152 15.4 µM -2.17124774882857 0.0415312504583364 no 3196 0.0149562248578053 1063 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_922 1866-0035 480 µM -2.17433727426068 0.0413129285339414 no 3197 0.0148399075261481 1044 3156169
SGTC_208 k072-0098 12.366 µM -2.17501301006077 0.0412653017307445 no 3198 0.014814570730258 1065 5948901
SGTC_2328 6201408 200 µM -2.19207579448882 0.0400773728124748 no 3199 0.0141870171112499 1063 2890418
SGTC_1944 st076371 56.9 µM -2.20377449005319 0.0392790680530766 no 3200 0.0137701037343996 1067 24208455
SGTC_231 b-estradiol 524 µM -2.20418184082811 0.0392515057721828 no 3201 0.0137557791638124 1077 450 A steroid.
SGTC_513 4245-1575 41.7 µM -2.20694919573332 0.0390646766564888 no 3202 0.0136588044456215 1057 719745
SGTC_1143 3454-2408 5.08 µM -2.21441905738694 0.0385639851831362 no 3203 0.0133999825643271 1042 X1143
SGTC_1635 st007035 42.4 µM -2.23780471847025 0.0370302083602278 no 3204 0.0126168962942906 1047 3716403
SGTC_3174 9107204 49.47 µM -2.2405803026407 0.036851525216403 no 3205 0.0125266368965848 1082 3938802
SGTC_2265 7929201 200 µM -2.24191008254142 0.0367661684155944 no 3206 0.0124835921378169 1073 1265108
SGTC_2483 5729050 27.16 µM -2.242232711943 0.0367454836552723 no 3207 0.0124731680036566 1066 2865180
SGTC_990 3985-0011 41.3 µM -2.24836480835871 0.0363541424641732 no 3208 0.0122764686379418 1054 5399565 YGL099W LSG1
SGTC_1010 4112-3296 15.2 µM -2.25207287067391 0.0361191591084076 no 3209 0.0121588336963063 1064 704384
SGTC_623 k072-0108 16.9 µM -2.25749605404996 0.0357777280317209 no 3210 0.0119885478887121 1069 5382803
SGTC_641 4092-0595 30 µM -2.26016517000235 0.0356106603589914 no 3211 0.011905500830777 1082 786260
SGTC_523 1934-0222 13.7 µM -2.26116388419147 0.0355483125903274 no 3212 0.0118745553111707 1079 1361595
SGTC_2064 5220758 200 µM -2.26419444174604 0.0353596684145513 no 3213 0.0117810791503744 1076 788518
SGTC_2832 7992762 51.95 µM -2.27240211844935 0.0348528818926245 no 3214 0.01153111694279 1054 2985177
SGTC_2182 6325192 200 µM -2.27383534891811 0.0347650009751875 no 3215 0.0114879440127585 1064 736248
SGTC_1265 0819-1001 68.8 µM -2.27539910069497 0.0346693245689793 no 3216 0.0114409996405629 1079 3106768
SGTC_501 nsc-95397 161 µM -2.28303435988016 0.0342052705873966 no 3217 0.011214172242244 1070 262093
SGTC_212 3807-4682 38.772 µM -2.28504973620171 0.0340836359447807 no 3218 0.0111549557931946 1079 3125501 YBL034C STU1
SGTC_323 4013-0906 34.3 µM -2.28929205633316 0.0338287599636519 no 3219 0.0110311944716262 1079 2910086
SGTC_748 act1.228 77.9 µM -2.2901820666534 0.0337754881640183 no 3220 0.0110053822842354 1080 4421505 YNR035C ARC35
SGTC_428 3448-4153 16.5 µM -2.29526301867591 0.0334726866977528 no 3221 0.0108590278010978 1070 3834874
SGTC_3173 9105693 49.47 µM -2.29540448716029 0.0334642879082224 no 3222 0.010854977221754 1071 17096658
SGTC_1852 st056254 31.4 µM -2.297830125608 0.0333205507945027 no 3223 0.0107857297223428 1084 442583
SGTC_312 4092-0653 6.84 µM -2.29956580541341 0.0332180112416232 no 3224 0.0107364156111814 1055 1148278
SGTC_1597 7-benzyloxygramine 47.5 µM -2.30119482104925 0.0331220097253419 no 3225 0.0106903107517287 1051 260807
SGTC_2978 9011784 42.97 µM -2.32039926180674 0.0320073855341367 no 3226 0.0101596443959837 1054 2994934
SGTC_2424 5537928 59.2 µM -2.32552564985613 0.0317151448052705 no 3227 0.0100219350051498 1058 5382802
SGTC_2141 5621638 7.665 µM -2.33712378570284 0.0310620992628603 no 3228 0.00971637428486635 1082 2856238
SGTC_1728 st035614 33.7865 µM -2.34155316636726 0.030815652020047 no 3229 0.00960184530175005 1072 15945546
SGTC_3249 9135183 49.47 µM -2.34451478747336 0.0306517744318776 no 3230 0.00952592750998439 1042 4902779
SGTC_2766 oltipraz 83.91 µM -2.34970948283983 0.0303660757839481 no 3231 0.00939403436183638 1011 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_14 0354-0009 295 µM -2.36434010421821 0.0295732565489132 no 3232 0.00903111120443832 1088 1713507
SGTC_2034 5197015 53.07 µM -2.37760217862922 0.0288695164501787 no 3233 0.00871280718861287 1082 780676
SGTC_2270 7924575 90.91 µM -2.37986208761505 0.0287509957755388 no 3234 0.00865955925506552 1074 1262135
SGTC_2213 7173844 200 µM -2.38444799737049 0.0285117315192248 no 3235 0.00855238264610993 1082 892728
SGTC_3025 9087895 49.47 µM -2.39230786189303 0.0281055058123973 no 3236 0.00837139592625842 1075 17173641
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -2.3925717924523 0.0280919490064335 no 3237 0.00836537727402563 1075 115019
SGTC_1867 st057372 64 µM -2.39335608996284 0.0280516956535436 no 3238 0.00834751462650189 1084 688837
SGTC_1753 st043925 64 µM -2.40452132231369 0.0274838406122754 no 3239 0.00809683075191113 1088 670181
SGTC_3178 9107506 49.47 µM -2.41234856955695 0.0270914938708448 no 3240 0.00792506005348002 1082 8897194
SGTC_377 3970-0964 33.1 µM -2.41495291914869 0.0269619896265957 no 3241 0.00786862185998933 1080 16481235
SGTC_2575 plumbagin 510 nM -2.4316066007495 0.0261460288969883 no 3242 0.00751601209624467 1076 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_2468 5987765 72.9 µM -2.44030797011881 0.0257279772287467 no 3243 0.00733737278095329 1079 26772094
SGTC_169 k015-0017 16.025 µM -2.4639555544447 0.0246200206840983 no 3244 0.00687065748824119 1085 1840002
SGTC_2913 7966556 36.57 µM -2.46601978202334 0.0245252350051979 no 3245 0.00683118943179166 1048 2976516
SGTC_2437 5741531 144.16 µM -2.46697057362155 0.0244816794687178 no 3246 0.00681307774650217 1063 2262990
SGTC_1347 1493-0251 600 nM -2.48137160567728 0.0238298717284344 no 3247 0.00654389255545135 1023 3986378
SGTC_2062 5245942 200 µM -2.49058336893308 0.0234206349169542 no 3248 0.00637667857551896 1088 1376160
SGTC_1612 st002233 45.4 µM -2.4926218514371 0.0233308779352641 no 3249 0.00634019064539209 1074 1035021
SGTC_116 0155-0182 31.788 µM -2.49344876821505 0.0232945503618689 no 3250 0.00632544197189915 967 771486
SGTC_1922 5578187 25 µM -2.49495936529009 0.0232283107070864 no 3251 0.00629857775254933 1067 1350412
SGTC_2097 5376186 200 µM -2.49755411757719 0.0231149009637242 no 3252 0.00625266878781845 1080 742755
SGTC_1917 st066507 28.5 µM -2.4987522134609 0.0230626929180698 no 3253 0.00623157104682127 1060 3156428
SGTC_124 0136-0217 7.121 µM -2.50128540485531 0.0229526338376025 no 3254 0.00618717053241964 1070 3976905
SGTC_229 benomyl 22.8748 µM -2.51327090123664 0.0224378828287177 no 3255 0.00598087210383639 1086 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_3080 9117754 49.47 µM -2.51734344138345 0.0222652070594997 no 3256 0.00591217532825413 1077 9550191
SGTC_1878 temozolomide 1 mM -2.52025729623438 0.0221423487824287 no 3257 0.00586345395142204 1082 5394 DNA alkylating agent.
SGTC_1926 methyl fluorone black 53.6 µM -2.5226308195741 0.0220426960521267 no 3258 0.00582403079274691 1056 72721 Reacts with homocysteine.
SGTC_3027 9089541 49.47 µM -2.53621344743738 0.0214796819592985 no 3259 0.0056029204892831 1082 9943819
SGTC_601 0986-0029 62.9 µM -2.53670101796123 0.021459699763647 no 3260 0.00559512388088607 1073 24747981
SGTC_2271 7849410 118.62 µM -2.5391726689637 0.0213586451961354 no 3261 0.00555574842128529 1078 972430
SGTC_398 bronopol 33.3 µM -2.54022072356316 0.0213159166491696 no 3262 0.0055391264893549 1081 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_1081 sertraline 6 µM -2.5722257350353 0.0200454724905808 no 3263 0.0050523491428047 1079 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_2139 5578692 56.4705 µM -2.58563891003932 0.0195324579334662 no 3264 0.00485993489715365 1062 650991 YMR113W FOL3
SGTC_2607 solasodine 47.35 µM -2.58597055397752 0.0195199161181755 no 3265 0.0048552612938716 1081 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_298 1391-0729 10 µM -2.61097380674916 0.0185938608321359 no 3266 0.00451424043007797 1087 3237558
SGTC_909 3448-9333 149 µM -2.61952365530454 0.0182859000372717 no 3267 0.00440263327748294 1084 3344074
SGTC_149 3970-0822 46.1 µM -2.62089848071681 0.0182367874234403 no 3268 0.00438491864596711 1080 3114250 YBL034C STU1
SGTC_2510 benzyl isothiocyanate 8.31 µM -2.6261916353888 0.0180487492001906 no 3269 0.00431730947140909 1071 2346 DNA damaging agent; causes G2/M arrest.
SGTC_36 0335-0881 14.2 µM -2.65585648050244 0.017025229156349 no 3270 0.00395536368065638 1066 23828853
SGTC_383 2324-0395 7.37 µM -2.66177583373375 0.0168270445998507 no 3271 0.00388648125195476 1046 3146421
SGTC_3145 9085516 49.47 µM -2.6629263956108 0.0167887527903548 no 3272 0.00387321782009165 1086 25236195
SGTC_2977 9011197 71.43 µM -2.66578021032429 0.0166940966550387 no 3273 0.00384049455979469 1077 2704722
SGTC_3213 9129884 49.47 µM -2.67405010415606 0.0164223731402171 no 3274 0.00374706269917113 1076 17190742
SGTC_137 0438-0332 85.389 µM -2.67480014101408 0.0163979175710796 no 3275 0.00373869056281019 1075 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_1605 st000082 49.1 µM -2.67698333561349 0.0163269101254492 no 3276 0.00371441648829741 1073 1114022
SGTC_866 0495-0101 262 µM -2.70016528237759 0.0155890303083093 no 3277 0.00346525179042903 1076 635694
SGTC_1763 st044482 94.5 µM -2.75991302527519 0.0138178879154758 no 3278 0.00289083758651886 1082 88505
SGTC_2519 cryptotanshinone 88.04 µM -2.77082409506351 0.0135139159642118 no 3279 0.00279573121808612 1069 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_2869 9037858 32.47 µM -2.78071799013897 0.0132432891856948 no 3280 0.00271194156232261 1090 27187042
SGTC_1488 4013-0813 75.9 µM -2.7921247359503 0.0129371039114929 no 3281 0.00261815830671173 1093 2910057
SGTC_3339 9145883 14.936 µM -2.80960429599628 0.0124797896256874 no 3282 0.00248012223165484 1071 2030670
SGTC_2448 5185112 27.17 µM -2.81082170718507 0.012448466703015 no 3283 0.00247075801915811 1086 5718189
SGTC_1476 4112-3294 3.34 µM -2.82359465415248 0.0121239131122916 no 3284 0.0023744200665974 1070 704369
SGTC_2975 9084847 53.72 µM -2.8333335172511 0.0118814067751561 no 3285 0.00230326480636648 1083 27211724
SGTC_2696 st077691 74.316 µM -2.84792260064587 0.011526001601613 no 3286 0.00220028127476105 1080 757133
SGTC_3180 9109287 49.47 µM -2.85265296742972 0.0114127645475169 no 3287 0.002167797006921 1085 18891271
SGTC_2688 kanamycin b 96.69 µM -2.87211073852847 0.0109570830585223 no 3288 0.0020387002970961 1065 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_3108 9121785 49.47 µM -2.87214598030923 0.0109562723065602 no 3289 0.00203847294760953 1057 17140271
SGTC_524 r073-0010 27.8 µM -2.87902010452286 0.0107991248841139 no 3290 0.00199456451497421 1084 2772106
SGTC_1940 st075990 51.1 µM -2.8800124247464 0.010776602572884 no 3291 0.00198829749682018 1090 1084979
SGTC_376 3970-0862 59.1 µM -2.93311918918063 0.00962941172437653 no 3292 0.00167787519540419 1086 3135186
SGTC_596 1155-0152 116 µM -2.96103588795139 0.00907030456389687 no 3293 0.0015330310498203 1091 280313
SGTC_1853 st056710 91.2 µM -2.96888331720128 0.00891834799601979 no 3294 0.00149442032788233 1092 269167
SGTC_645 0845-0943 5.41 µM -2.97020091312981 0.00889305413685805 no 3295 0.00148802520318359 1088 1885106
SGTC_1613 st002381 52.1 µM -2.97054115239099 0.008886532792222 no 3296 0.0014863778686494 1092 551167
SGTC_1797 st048695 56.8 µM -3.04877557365962 0.00749389767841572 no 3297 0.0011488803240688 1081 592262 YIL048W NEO1
SGTC_1219 1469-0211 33.1 µM -3.08997124872979 0.00684089181707822 no 3298 0.00100087935855309 1085 6822282
SGTC_141 0443-0274 32.331 µM -3.12444338269873 0.00633362992248987 no 3299 0.000890709004050966 994 1627241
SGTC_966 1300-0360 30.2 µM -3.16836062683782 0.00573577631155 no 3300 0.000766506161802507 1063 70588
SGTC_3104 9120930 49.47 µM -3.17129522520297 0.00569767353900133 no 3301 0.000758804115456397 1094 17014836
SGTC_2344 7990960 76.95 µM -3.19290040193473 0.00542400128844844 no 3302 0.00070425759485487 1074 140813
SGTC_2015 5119600 184 µM -3.20501608735837 0.00527570080606371 no 3303 0.000675274659474404 1088 2828786
SGTC_1353 1498-1206 8.11 µM -3.20967534850197 0.00521963695419272 no 3304 0.000664424836634744 1023 6756808
SGTC_1015 4130-4525 82 µM -3.21457173775803 0.00516129161995868 no 3305 0.000653196335698314 1094 1363237
SGTC_2965 9082772 38.63 µM -3.23629675369141 0.00490935847682968 no 3306 0.000605457127888541 995 16459634
SGTC_2013 4024628 200 µM -3.26069278028601 0.00463956274500988 no 3307 0.000555701938372697 1089 5230760
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -3.26768663869973 0.00456469744689952 no 3308 0.00054215173457103 1092 1241132 A phosphatase inhibitor.
SGTC_2305 7443522 69.23 µM -3.27697103929465 0.00446697983922103 no 3309 0.00052463565599345 1089 5415886
SGTC_2164 5685496 200 µM -3.31479071837913 0.00408795765012356 no 3310 0.000458558795206577 1091 759046
SGTC_2427 5545055 42.75 µM -3.33956187053234 0.00385556947614135 no 3311 0.000419553286047382 1092 5372858
SGTC_3151 9099821 49.47 µM -3.34161249354282 0.00383687289150526 no 3312 0.000416466282730563 1086 17174189
SGTC_2659 sanguinarine 24.21 µM -3.37351261311847 0.00355630477660983 no 3313 0.0003710782313293 1077 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_2896 9052656 71.43 µM -3.38285122943897 0.00347773012612066 no 3314 0.000358687408188794 1073 6469436
SGTC_2857 9024691 58.44 µM -3.39560355419061 0.00337295165085189 no 3315 0.00034238732463326 1091 16478292
SGTC_163 TUB2.036 7.546 µM -3.40332016582652 0.0033109351789223 no 3316 0.000332861106237868 1082 15992207 YJR013W GPI14
SGTC_3074 9116018 49.47 µM -3.40735116137714 0.00327894845168519 no 3317 0.000327983367157437 1091 17027303
SGTC_1734 st037168 69.4 µM -3.42544228313628 0.00313878790600824 no 3318 0.000306899665774215 1090 708907
SGTC_1674 st016616 23.6 µM -3.44011694829694 0.00302908335504231 no 3319 0.000290731437351654 1089 625830
SGTC_1941 st076221 61.8 µM -3.44673345258205 0.002980759293571 no 3320 0.000283704048753025 1082 2828568
SGTC_852 0418-0143 439 µM -3.49700886776048 0.00263568230666519 no 3321 0.000235253095878619 1081 5369229
SGTC_2624 nerol 100 µM -3.50585310282596 0.00257885363821722 no 3322 0.000227573170634947 1090 637566 A natural product oil.
SGTC_3124 9127567 49.47 µM -3.52184512201309 0.00247890099385288 no 3323 0.000214277218193454 1094 17592030
SGTC_255 tunicamycin 200.472 nM -3.52628993461115 0.00245174944135874 no 3324 0.000210712667969341 1086 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_778 3456-2434 196 µM -3.52874714558535 0.00243685507409028 no 3325 0.000208765934048878 1019 5539063
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -3.55039611879559 0.00230912557063408 no 3326 0.00019232595328177 1090 5024745
SGTC_1113 artemisinin 1.17947 µM -3.59954743187244 0.00204135040189818 no 3327 0.000159385743172649 1085 2240 An anti-malaria and mitochondrial poison.
SGTC_2877 9040724 71.43 µM -3.64625281388498 0.00181334267858012 no 3328 0.000133046097955308 1093 6463895
SGTC_2021 4019055 173 µM -3.65211946661685 0.00178640282880837 no 3329 0.000130042415853064 1089 44827708 YER133W GLC7
SGTC_173 1273-0061 2.693 µM -3.69163873581555 0.00161421388750996 no 3330 0.000111406901035396 1079 2847414 YPL266W DIM1
SGTC_2054 5233173 129 µM -3.72079202410974 0.00149703731867088 no 3331 9.92994724299667e-05 1034 6889
SGTC_1556 plumbagin 1.48 µM -3.7412122510692 0.00141964100775067 no 3332 9.15673865639242e-05 1070 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_1264 0783-0040 158 µM -3.75883115547254 0.00135581736665325 no 3333 8.53544929544488e-05 1090 2855798
SGTC_1522 st012842 45.6 µM -3.79934791738151 0.00121887400058717 no 3334 7.25386534869685e-05 1073 3491067 YOR116C RPO31
SGTC_674 0498-0004 451 µM -3.8349701797025 0.00110905846964561 no 3335 6.27897647444551e-05 1080 4231473
SGTC_1725 st036284 20.55 µM -3.84730831615227 0.00107318882106334 no 3336 5.97113227744718e-05 1089 707914
SGTC_3125 9127534 49.47 µM -3.89327808812095 0.000948709016539919 yes 3337 4.94493356288066e-05 1093 1639235
SGTC_344 k064-0035 6.43 µM -3.91242955876219 0.000900877988142162 yes 3338 4.56860976133874e-05 1086 5088750
SGTC_1230 0170-0365 3.77 µM -4.06884098863567 0.000585647987466805 yes 3339 2.36237884201652e-05 1095 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_70 0141-0289 43.283 µM -4.14386415995678 0.000473898313364029 yes 3340 1.707510402489e-05 1088 352408
SGTC_3170 9103054 49.47 µM -4.14957418204142 0.000466258841661047 yes 3341 1.66547164950484e-05 1091 16432970
SGTC_1036 k216-0215 33.5 µM -4.15383981774275 0.000460626453472534 yes 3342 1.63471042489311e-05 1071 622330
SGTC_2623 humulene 100 µM -4.18183674945773 0.00042519593937743 yes 3343 1.44581785102948e-05 1095 6187145 An anti-inflammatory.
SGTC_3081 9117243 49.47 µM -4.28082343477003 0.000319199507101504 yes 3344 9.31015255729866e-06 1093 45595589
SGTC_2566 crystal violet carbinol 226 nM -4.31553729502116 0.00028826324992275 yes 3345 7.96075836249984e-06 1093 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_2917 7979103 53.79 µM -4.54807159677467 0.000142934691782229 yes 3346 2.70698592139631e-06 1093 2980565
SGTC_1206 3978-0017 132 µM -4.85947227558905 5.30937736148172e-05 yes 3347 5.88495311009318e-07 1092 3873677
SGTC_2038 4100038 30.985 µM -5.08025530752412 2.5392034980872e-05 yes 3348 1.88463977610485e-07 1090 3596803
SGTC_2928 9011484 9.79 µM -5.11891164324303 2.22479355432133e-05 yes 3349 1.53651940151364e-07 1092 2994751
SGTC_393 acivicin 6.25 µM -5.13768225377385 2.08579611615088e-05 yes 3350 1.3907383167864e-07 1091 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_3222 9128301 49.47 µM -5.29573153457681 1.20136659998443e-05 yes 3351 5.92704438447118e-08 1093 4911358
SGTC_3062 9077494 49.47 µM -5.36777777258692 9.29540080359675e-06 yes 3352 3.98563424059148e-08 1044 16459633
SGTC_2066 5222451 176 µM -6.00958078402824 8.22493006399001e-07 yes 3353 9.30018313955033e-10 1093 2281147
SGTC_2925 9010536 32.5 µM -6.21078538835977 3.65113787292352e-07 yes 3354 2.63602173792708e-10 1084 2994177
SGTC_2980 9014342 25.29 µM -6.49539210666395 1.1093687962334e-07 yes 3355 4.14087115018334e-11 1093 2996599
SGTC_3126 9127922 49.47 µM -9.68312521099283 5.77158360000824e-15 yes 3356 1.77836985502711e-22 1095 45595682