SGTCid condition conc unit NUP170|YBL079W.score NUP170|YBL079W.strain.pval NUP170|YBL079W.strain.significant NUP170|YBL079W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_2858 9025781 8.96 µM 18.4949671341102 8.57626398819218e-62 yes 1 1.13340102969887e-76 7 4894980 YPL153C RAD53 SGTC_1877 wortmannin 25 µM 15.06814199407 9.97479042910715e-42 yes 2 1.31194406417186e-51 2 312145 A covalent inhibitor of PI 3-kinase. SGTC_2651 TUB2.036 5 µM 14.9826513626093 2.80293769083457e-41 yes 3 4.76682821249654e-51 5 15992207 YFL037W TUB2 SGTC_1304 1165-0502 251 µM 11.4020334592443 9.4834679639298e-25 yes 4 2.0423267057627e-30 6 767425 SGTC_2322 7413319 38.22 µM 9.2977408221215 4.29063657951373e-17 yes 5 7.17307182343252e-21 24 1840400 SGTC_1750 st081859 2.357 µM 9.18601073595948 9.92048378282339e-17 yes 6 2.03840235260776e-20 49 5291695 SGTC_505 gw-5074 63.9 µM 8.34883639632582 3.87338963122236e-14 yes 7 3.44693753932121e-17 17 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_1941 st076221 61.8 µM 7.72115613832319 2.36646210416497e-12 yes 8 5.76396162469552e-15 23 2828568 SGTC_1495 4469-0029 237 µM 7.71122363119386 2.51931189940758e-12 yes 9 6.23085375196945e-15 26 793680 SGTC_2526 patulin 37.61 µM 7.60315187115242 4.95303109795099e-12 yes 10 1.44501996367047e-14 17 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_59 0330-0160 1.33 µM 7.55665836550633 6.60620977049217e-12 yes 11 2.06778152023582e-14 17 4293482 SGTC_1687 st020778 55.3625 µM 7.40222067690758 1.69884830864222e-11 yes 12 6.69628465842485e-14 78 4259299 SGTC_103 0844-0104 51.839 µM 7.19676271503709 5.79824459412089e-11 yes 13 3.08294632280061e-13 58 5375804 SGTC_2752 diclazuril 33.15 µM 6.88304127196833 3.54570789849904e-10 yes 14 2.9294021878338e-12 48 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_528 3492-0019 172 µM 6.65627511656261 1.25125991502433e-09 yes 15 1.40427160544907e-11 104 2869262 SGTC_852 0418-0143 439 µM 6.59526193243275 1.74469976378902e-09 yes 16 2.12252857436695e-11 20 5369229 SGTC_2077 5212015 200 µM 6.4155837489358 4.56632310834521e-09 yes 17 7.01421340664173e-11 20 780900 SGTC_955 1216-0110 33 µM 6.05374053273055 2.93713781444567e-08 yes 18 7.07602480195931e-10 31 3619719 SGTC_513 4245-1575 41.7 µM 5.84024890907319 8.39740077675703e-08 yes 19 2.60614440067844e-09 51 719745 SGTC_52 0329-0193 875 nM 5.80340881377838 1.00303761607907e-07 yes 20 3.24900491075213e-09 10 3739292 SGTC_3025 9087895 49.47 µM 5.79262839260443 1.0563639589979e-07 yes 21 3.46466575658114e-09 15 17173641 SGTC_3059 1327-0034 3 µM 5.58792114945671 2.77699655632384e-07 yes 22 1.14901968830922e-08 28 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_488 nitrendipine 139 µM 5.52654663397665 3.68708582170422e-07 yes 23 1.63297738694405e-08 18 4507 Dihydropyridine L-type calcium channel blocker. SGTC_2430 5571206 200 µM 5.45184532334503 5.18581431336229e-07 yes 24 2.49249034681338e-08 30 1731771 SGTC_1700 st030840 7.9285 µM 5.43109145850774 5.69691728496153e-07 yes 25 2.80052089443311e-08 7 5499307 SGTC_759 3486-0358 89.3 µM 5.4227454751724 5.91583138076117e-07 yes 26 2.93452670300684e-08 7 875103 SGTC_1287 0971-0001 34.6 µM 5.3936538154433 6.74395623558632e-07 yes 27 3.45195861202155e-08 25 4665869 SGTC_1161 k007-0610 110 µM 5.38710805507382 6.94509486864245e-07 yes 28 3.58001959157879e-08 71 5843850 SGTC_1226 3909-7979 35.4 µM 5.37579761817437 7.3063138328846e-07 yes 29 3.81221977095002e-08 17 6615510 SGTC_562 3772-2733 112 µM 5.30374972518375 1.00684222460397e-06 yes 30 5.67239129504549e-08 45 2876874 YIL048W NEO1 SGTC_115 0527-0192 112.043 µM 5.21301061104272 1.49927262254547e-06 yes 31 9.29001320107459e-08 27 4233931 SGTC_628 1636-0253 16 µM 4.94765639929491 4.63200021762516e-06 yes 32 3.75561733617918e-07 16 4456143 SGTC_2932 9016711 44.54 µM 4.92531960824073 5.08081976466811e-06 yes 33 4.21112890172413e-07 25 7117328 SGTC_108 0509-0257 621.132 µM 4.90256939670443 5.58047912595781e-06 yes 34 4.72955909431595e-07 24 536624 SGTC_1694 st024011 44.9 µM 4.85487732473429 6.78440561250497e-06 yes 35 6.02306463819438e-07 19 2787533 SGTC_2405 ticlatone 3.52 µM 4.82531543339728 7.65102809580823e-06 yes 36 6.98909296428212e-07 40 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_568 1193-0097 7.48 µM 4.75502667061447 1.01551453119539e-05 yes 37 9.92101104078858e-07 99 3646150 SGTC_3063 1327-0034 4 µM 4.53742652715319 2.38209866253436e-05 yes 38 2.84724300588725e-06 34 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1232 0279-0259 161 µM 4.50706638247813 2.67530200478749e-05 yes 39 3.28650371894786e-06 5 1560000 SGTC_994 3910-0338 138 µM 4.48914800825921 2.86406612664984e-05 yes 40 3.57543006895344e-06 33 3479481 SGTC_275 trichlorophene 5.69 µM 4.38029086445494 4.31108584331682e-05 yes 41 5.92604983233957e-06 205 62616 SGTC_315 k915-0449 187 µM 4.31483254327901 5.48905891095369e-05 yes 42 7.98619656982499e-06 47 20970215 YNL149C PGA2 SGTC_18 0111-0177 500 nM 4.24210939358544 7.15144924857892e-05 yes 43 1.10714353817842e-05 57 721752 SGTC_839 0122-0028 230 µM 4.22164650499934 7.69855490105038e-05 yes 44 1.21262121756911e-05 34 759448 SGTC_1212 0520-0165 585 µM 4.10125117789165 0.000118026871731262 yes 45 2.05461106956919e-05 25 5403258 SGTC_2692 st077426 47.7 µM 4.07389837440182 0.000129860326711183 yes 46 2.31163310106285e-05 22 25238571 SGTC_56 0957-0365 83.25 µM 4.06770578421165 0.000132689583869476 yes 47 2.37391373180916e-05 45 6752360 SGTC_2426 5582046 32.21 µM 4.05785980793391 0.000137307249655706 yes 48 2.47622403802234e-05 26 2251934 SGTC_1803 st050068 52.4 µM 3.97728365224887 0.000181167025137408 yes 49 3.48534976064507e-05 175 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_2084 5306078 60.6385 µM 3.95058614467362 0.00019837964420475 yes 50 3.89800154197152e-05 21 679340 SGTC_127 0180-0333 59.125 µM 3.94630560251554 0.000201277601308615 yes 51 3.96831514898382e-05 40 771601 SGTC_2642 cholecalciferol 100 µM 3.90897817555746 0.000228278065619447 yes 52 4.63436680133168e-05 22 9821465 A vitamin D precursor, similar to steriods. SGTC_1277 0873-0036 22 µM 3.90070851825025 0.000234700466877455 yes 53 4.79557872864784e-05 23 5965735 SGTC_895 0964-0006 13.7 µM 3.89840393816655 0.000236520061157795 yes 54 4.84143991612908e-05 16 6738897 SGTC_3084 9116877 49.47 µM 3.87700145630954 0.000254058419258919 yes 55 5.2875862741956e-05 7 27241325 SGTC_1306 1185-0270 9.02 µM 3.78733922801507 0.000341546321377383 yes 56 7.61345738427108e-05 55 1548076 SGTC_533 1222-0222 6.71 µM 3.78084361790694 0.000348865448960653 yes 57 7.8148916250515e-05 35 3982874 SGTC_352 k048-0007 5.11 µM 3.76146912520537 0.000371571112131498 yes 58 8.44591374275738e-05 85 6811911 SGTC_2845 9003024 42.97 µM 3.75385656249221 0.000380862352198225 yes 59 8.7067266862155e-05 52 2990173 SGTC_87 0100-0052 35.5 µM 3.73149372210199 0.000409418964843051 yes 60 9.51738772673401e-05 127 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_2307 7538926 6.34 µM 3.71172335000448 0.000436306758180067 yes 61 0.000102926455214103 49 96582 SGTC_8 0354-0001 70 µM 3.66872759719588 0.000500527215152076 yes 62 0.00012188031666112 90 4993152 SGTC_2049 5262831 67.185 µM 3.66536692793898 0.00050589877360889 yes 63 0.000123492105960676 37 763417 SGTC_1997 st073024 93.8 µM 3.64863548487183 0.000533444666110323 yes 64 0.000131818428811458 13 686268 SGTC_232 clozapine 119 µM 3.6389435679539 0.000550029126459136 yes 65 0.000136879387709729 78 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_2421 5690543 90.72 µM 3.63313462888973 0.000560196390620375 yes 66 0.000139999414893149 26 3397993 SGTC_1233 0325-0408 14.2 µM 3.63291427248756 0.000560585475052997 yes 67 0.000140119071937377 27 12874 SGTC_1641 st009299 47.1 µM 3.62721057614758 0.00057074386791441 yes 68 0.000143249817250198 11 4046054 SGTC_1826 st055655 41.6 µM 3.61082237875647 0.000600886049295148 yes 69 0.000152613825098644 52 676168 SGTC_214 4373-3496 70 µM 3.5903899235168 0.00064052549759842 yes 70 0.000165091825268227 79 3779166 SGTC_70 0141-0289 43.283 µM 3.58157381415419 0.000658363160143353 yes 71 0.000170765306067684 206 352408 SGTC_2859 9028643 45.46 µM 3.5734674984984 0.000675168101514192 yes 72 0.000176142493716173 24 17151580 SGTC_444 curcumin 90.4 µM 3.56104719520939 0.000701685209695081 yes 73 0.000184689337927748 39 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_908 3448-7491 47.7 µM 3.53367109190961 0.000763557368496922 yes 74 0.00020491536970788 151 1203031 SGTC_2482 5981709 142.65 µM 3.53250315536017 0.00076630552066238 yes 75 0.000205822656795682 51 877755 SGTC_2918 7977171 22.06 µM 3.43788584748695 0.00102172798569367 no 76 0.000293137396851489 42 2236483 SGTC_2693 st077581 40.7 µM 3.42934029824525 0.00104827723611823 no 77 0.000302525195216276 60 25238761 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 3.42680189952567 0.00105628454259529 no 78 0.00030536722173238 43 6312947 SGTC_786 4544-0069 423 µM 3.39982112161585 0.00114492944321745 no 79 0.000337149750090511 57 748821 YLR208W SEC13 SGTC_863 0466-0191 129 µM 3.35214825971771 0.00131838428112617 no 80 0.00040093532085284 98 765160 YPR165W RHO1 SGTC_1642 st009582 77.7 µM 3.34963438177997 0.00132816543826161 no 81 0.000404591467167963 33 6739311 SGTC_1013 4112-3890 241 µM 3.33629830487942 0.00138117243960249 no 82 0.000424510049348995 59 705171 SGTC_2935 9038016 29.96 µM 3.32350901527561 0.00143381429388482 no 83 0.000444462747432436 39 6463195 SGTC_3080 9117754 49.47 µM 3.31805141479534 0.00145683079270093 no 84 0.000453238985001659 39 9550191 SGTC_804 1595-0054 20.9 µM 3.30865977840484 0.00149722921042841 no 85 0.000468718388127072 65 761523 Stimulates phospholipase C. SGTC_664 1222-0054 14.9 µM 3.30812942674748 0.00149954073593299 no 86 0.000469606963726118 59 6813991 SGTC_31 0508-1974 57.237 µM 3.29929724857226 0.00153851720726009 no 87 0.000484636084817765 50 6810525 SGTC_575 k072-0246 11.9 µM 3.29769230640004 0.00154569823469154 no 88 0.000487414474847051 45 6796779 SGTC_2740 felodipine 17.08 µM 3.26745691353754 0.00168681957406922 no 89 0.000542591916342434 33 3333 L-type calcium channel blocker SGTC_805 3852-0218 479 µM 3.23282887787242 0.00186278879391006 no 90 0.000612854800459259 104 6615355 SGTC_293 4049-0273 38.5 µM 3.22249768211426 0.00191843113154021 no 91 0.000635390969606428 35 1380311 SGTC_1425 4048-4433 7.33 µM 3.22014827956462 0.00193129358126347 no 92 0.000640621533496018 71 23734946 SGTC_406 estrone 100 µM 3.20036883908128 0.00204272729599415 no 93 0.000686259111768559 27 5870 A steroid. SGTC_493 zm226600 134 µM 3.19736722490894 0.00206013869724469 no 94 0.000693441213569359 43 5240098 A potassium channel opener. YCR052W RSC6 SGTC_816 0325-0417 81.3 µM 3.16154952521446 0.00227854923536902 no 95 0.000784660648499116 36 68101 SGTC_1712 st032288 53.4 µM 3.11763156635719 0.00257487192876904 no 96 0.000911552771655788 252 2883011 SGTC_598 3937-0236 20.2 µM 3.08650585806902 0.00280551608224648 no 97 0.00101261977994333 76 1379313 SGTC_842 0271-0008 11.1 µM 3.08631729999796 0.0028069683745457 no 98 0.00101326220782854 45 1221709 SGTC_910 3454-3003 490 µM 3.04059217707969 0.00317983920568133 no 99 0.00118056702822658 59 820824 SGTC_2688 kanamycin b 96.69 µM 2.99440705076973 0.00360113794513886 no 100 0.00137489412139036 538 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_3346 9158254 43.5805 µM 2.99010784728085 0.00364279737416398 no 101 0.001394394820581 69 17639500 SGTC_2847 9005661 71.43 µM 2.95298816520086 0.00402086485610817 no 102 0.001573570141847 26 2991449 SGTC_853 0419-0306 21 µM 2.93902669812086 0.00417191666287649 no 103 0.00164622355726991 53 762713 SGTC_1101 ebselen 5.29 µM 2.9347802890927 0.00421885563904881 no 104 0.00166891970260013 70 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_3354 9151612 71.43 µM 2.91511927056828 0.00444239757473653 no 105 0.00177776316695367 55 27261949 SGTC_683 panaxydol 45 µM 2.91442471244754 0.00445048453723508 no 106 0.00178172374340068 79 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_1026 k007-1105 30.6 µM 2.90674649895361 0.00454076452723136 no 107 0.00182604514724639 163 7066794 SGTC_2052 5265182 7.135 µM 2.88644726040676 0.0047873662492219 no 108 0.00194809019957806 80 1239884 SGTC_2273 7815444 169.05 µM 2.87214790854728 0.00496817814052318 no 109 0.0020384605089495 74 2824616 SGTC_2090 5301565 104.445 µM 2.87104400866077 0.00498238643410563 no 110 0.00204559281563347 102 2056344 SGTC_2489 cantharidin 73.42 µM 2.87070481565736 0.00498675945026367 no 111 0.00204778888878263 115 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2701 st077767 14.721 µM 2.8598111699894 0.00512903532184249 no 112 0.00211946663780422 111 5721188 SGTC_789 1309-1135 70.6 µM 2.8426704024096 0.00536022374627783 no 113 0.00223686544030545 90 3092424 SGTC_2806 7952793 58.44 µM 2.82707211070478 0.00557861207785804 no 114 0.0023487874134096 85 2972490 SGTC_1880 MG-132 525 µM 2.82302340455789 0.00563657366963235 no 115 0.0023786549290823 57 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_143 4032-1194 15.74 µM 2.82112608637462 0.0056639193734802 no 116 0.00239276948024287 158 1806963 SGTC_1301 naphtanilide LB 4.81 µM 2.81607056407444 0.00573735961847191 no 117 0.0024307493794784 57 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_2815 7968870 71.43 µM 2.81402067833098 0.00576737778490382 no 118 0.00244630405220105 89 2977326 YHR190W ERG9 SGTC_1801 st050089 28.441 µM 2.79851744442723 0.00599895360870013 no 119 0.00256688981381591 220 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_543 3844-1095 191 µM 2.78820596192153 0.00615750789110183 no 120 0.00265004180583823 127 4230703 SGTC_1244 0416-0015 52.5 µM 2.78652459258845 0.00618371048940878 no 121 0.00266382876958089 114 96201 SGTC_3060 1327-0027 12.5 µM 2.75566633187233 0.00668246347993322 no 122 0.00292863574601755 76 16000455 YPR107C YTH1 SGTC_1001 4048-4355 44.4 µM 2.75483776781096 0.00669633196233111 no 123 0.00293606220292743 89 21824233 SGTC_622 1348-1566 26.3 µM 2.74857616313164 0.00680196359421298 no 124 0.00299273636212794 85 7340407 SGTC_163 TUB2.036 7.546 µM 2.74443115709161 0.00687269596752906 no 125 0.0030307933416677 228 15992207 YJR013W GPI14 SGTC_1973 st070275 50.2 µM 2.73363698108847 0.00705995014349421 no 126 0.00313195311958244 62 17118334 SGTC_3086 9117350 49.47 µM 2.72205039521139 0.00726594749230763 no 127 0.00324391239811369 28 2679265 SGTC_841 0251-0215 91.2 µM 2.72165092251794 0.00727314324498066 no 128 0.00324783584829855 143 3888614 SGTC_295 k015-0027 31 µM 2.72093174452174 0.00728611372964219 no 129 0.0032549100685932 61 3887424 SGTC_2375 9072683 200 µM 2.71897081826517 0.00732158299885396 no 130 0.00327426925827686 100 16798029 SGTC_3201 9113999 49.47 µM 2.69219708844069 0.00782131530117732 no 131 0.0035491491967074 109 16649224 SGTC_567 1080-0542 68.4 µM 2.67662328570494 0.00812560164592463 no 132 0.00371840998085127 63 5950415 SGTC_188 3229-0966 278.469 µM 2.6751237462521 0.00815544209314023 no 133 0.00373508356726999 120 5722370 SGTC_2843 9000894 45.46 µM 2.67455117078615 0.00816686157414131 no 134 0.00374146778127145 42 2242070 SGTC_1327 1436-0082 2.18 µM 2.66473644430415 0.00836480310901843 no 135 0.00385243404978756 89 15992205 SGTC_527 4476-4215 268 µM 2.65644975589645 0.00853519434412869 no 136 0.0039484108729729 123 4418754 SGTC_881 0833-0569 170 µM 2.648951258597 0.00869199568849627 no 137 0.00403709877949267 107 5418700 SGTC_2570 licareol 100 µM 2.6441040780843 0.00879469434698798 no 138 0.00409537333003831 110 443158 SGTC_2038 4100038 30.985 µM 2.64272856209458 0.00882403088828892 no 139 0.00411204683988241 124 3596803 SGTC_1469 k284-2957 126 µM 2.63827243237632 0.00891965955039652 no 140 0.00416648039916556 73 23884841 SGTC_2814 7977482 42.97 µM 2.62379767049744 0.00923658170085799 no 141 0.00434777118582919 154 6456762 SGTC_46 0329-0187a 2.197 µM 2.62308352369929 0.00925246977694645 no 142 0.0043568953824078 179 46494817 SGTC_896 0964-0007 44.5 µM 2.59942743115117 0.00979245628387446 no 143 0.00466897100009086 69 6756758 SGTC_743 1275-0778 158 µM 2.58494435952387 0.0101364704593736 no 144 0.0048697356583777 146 2849257 YMR203W TOM40 SGTC_408 cantharidin 100 µM 2.57432740950019 0.0103953065746759 no 145 0.0050217590554761 106 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 2.55805561109626 0.0108031857325263 no 146 0.0052629628939292 117 521171 SGTC_96 0929-0093 37.281 µM 2.55788047503175 0.0108076505293489 no 147 0.00526561412583622 86 6991579 SGTC_1658 st012944 20 µM 2.54536881220976 0.011130798759521 no 148 0.0054581186708333 154 24207260 SGTC_1346 1488-2224 62.4 µM 2.54014638962786 0.0112681481021486 no 149 0.00554030395314916 82 3722427 SGTC_2745 rifampicin 24.3 µM 2.51819272443675 0.01186176329093 no 150 0.00589793787430267 32 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_951 1171-0579 82.7 µM 2.50905240740116 0.0121168013177283 no 151 0.00605277614052925 219 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_800 3448-7362 155 µM 2.49704536458176 0.0124590424894482 no 152 0.00626164673403213 379 15991913 SGTC_1746 st038117 42 µM 2.4947332778751 0.0125258973131057 no 153 0.00630259201691964 132 2898218 SGTC_2576 guaiol 23.12 µM 2.49341298862662 0.0125642130995487 no 154 0.00632607949821013 135 227829 SGTC_114 0364-0001 490.298 µM 2.48459816413433 0.0128226353262669 no 155 0.00648488720691135 165 4003655 SGTC_733 4069-0007 56.1 µM 2.46543266529159 0.0134004151786773 no 156 0.00684239468042372 213 5717425 YNL287W SEC21 SGTC_2015 5119600 184 µM 2.45686686828964 0.0136658317474683 no 157 0.00700773076859488 139 2828786 SGTC_1506 4226-2149 212 µM 2.45162254449028 0.0138305591197477 no 158 0.00711068765000248 148 991114 SGTC_445 e6 berbamine 66 µM 2.44576428215004 0.0140165928503989 no 159 0.00722727341757081 265 6610268 A calcium/calmodulin antagonist. SGTC_399 oxolinic acid 75 µM 2.44180739370517 0.0141434639221863 no 160 0.00730697052953185 83 4628 A DNA gyrase inhibitor. SGTC_2763 lisinopril 49.32 µM 2.43986531038353 0.0142060947820665 no 161 0.00734636942374206 69 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_3010 9080089 71.4286 µM 2.43045950481615 0.0145128173403921 no 162 0.00753984553623766 111 17027233 SGTC_2186 6124449 200 µM 2.43037248675803 0.0145156813968018 no 163 0.00754165624105938 123 3834182 YLR033W RSC58 SGTC_366 0181-0206 4.31 µM 2.42929711923941 0.0145511155254997 no 164 0.00756406452878282 181 274874 SGTC_1846 st056244 14.8 µM 2.42773822030579 0.0146026145260073 no 165 0.00759665265402947 152 5393182 SGTC_2417 cerulenin 830 nM 2.4161724154105 0.0149896178565407 no 166 0.00784231621856728 118 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_1828 st055811 49 µM 2.41018411699834 0.0151934336636506 no 167 0.0079722359203225 83 5877589 SGTC_2271 7849410 118.62 µM 2.39524492964718 0.015712304753883 no 168 0.00830463303202939 112 972430 SGTC_1475 4092-1048 11.7 µM 2.39223935075468 0.015818512124757 no 169 0.00837295887037934 174 2881759 SGTC_2536 dehydroabietamide 32.04 µM 2.3671286830771 0.0167301455433002 no 170 0.00896334926168792 168 3983547 SGTC_1135 dihydrocapsaicin 536.708 nM 2.36538894832268 0.0167949380862331 no 171 0.00900557202944934 168 107982 A Capsaicinoid. SGTC_149 3970-0822 46.1 µM 2.35461966189907 0.0172008112068569 no 172 0.00927083638602561 281 3114250 YBL034C STU1 SGTC_301 4119-0100 24.5 µM 2.3512928381417 0.0173278748699413 no 173 0.00935415194404768 208 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_376 3970-0862 59.1 µM 2.350730495859 0.0173494318140087 no 174 0.00936829953424805 144 3135186 SGTC_633 0437-0093 97.7 µM 2.34999336242606 0.017377723925161 no 175 0.0093868729239435 111 2831118 SGTC_1200 1643-0193 18.4 µM 2.34002863460574 0.0177640657651759 no 176 0.00964113072266435 142 5403974 SGTC_503 tyrphostin 8 294 µM 2.33621664393203 0.0179137860002055 no 177 0.00973997664041927 165 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_2331 7980721 200 µM 2.3285511587111 0.0182181164842805 no 178 0.00994142802778027 150 2981221 SGTC_854 0422-0053 192 µM 2.3233677313703 0.018426393460555 no 179 0.0100797030337616 127 3596728 SGTC_1183 1254-0324 198 µM 2.31903647234031 0.0186019812139664 no 180 0.010196529407288 124 5799357 SGTC_1234 0326-0494 15.5 µM 2.31543983685586 0.0187488681958196 no 181 0.0102944367539459 128 1547813 SGTC_2104 5389443 200 µM 2.3076615037724 0.0190699145393042 no 182 0.0105089854004123 159 2244536 SGTC_283 0987-0079 11.7 µM 2.30605358903893 0.0191368601592137 no 183 0.010553819073321 175 411556 SGTC_2065 5221596 34.26 µM 2.30261815932547 0.0192805641854661 no 184 0.0106501682616946 140 788581 SGTC_1924 st058459 75.1 µM 2.29649417671167 0.0195390052219095 no 185 0.0108238208700921 115 688683 SGTC_1760 st045453 10.4495 µM 2.29517461858093 0.019595076146199 no 186 0.0108615595739758 256 3323419 YIL048W NEO1 SGTC_3303 9125618 40.5795 µM 2.29420175217247 0.0196365028318535 no 187 0.0108894563596985 210 22695467 SGTC_2839 9003951 25.97 µM 2.287262850471 0.0199341378990728 no 188 0.011090242735208 113 2990634 SGTC_625 k213-0058 121 µM 2.27640340243102 0.0204076189535343 no 189 0.0114109381136653 323 3655420 SGTC_373 0844-0104 25.9 µM 2.27168684831936 0.0206162143146683 no 190 0.0115527155485361 200 5375804 SGTC_450 aminopyrene 156 nM 2.24793322965061 0.0216943981260547 no 191 0.012290223940524 182 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_2396 5342950 42.78 µM 2.23964358753768 0.0220817128075769 no 192 0.0125570352983694 213 1886677 SGTC_925 2064-1272 59.6 µM 2.23593797590175 0.0222567276272669 no 193 0.0126779171428289 162 6815817 SGTC_470 aa-861 153 µM 2.22312522963442 0.0228709146323424 no 194 0.013103678417248 223 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_716 1683-5115 658 µM 2.21889813576997 0.0230766501263171 no 195 0.0132468276903676 169 723597 SGTC_150 3970-0969 77.2 µM 2.21845162217438 0.0230984729664846 no 196 0.0132620273379044 256 6615640 SGTC_594 1487-1584 10.8 µM 2.21544918506173 0.0232456653684406 no 197 0.0133646242668455 165 5013332 SGTC_762 1165-0429 115 µM 2.21089996607935 0.0234701916506194 no 198 0.0135213825188038 155 5967793 SGTC_2970 9090938 41.86 µM 2.19247768648439 0.0243981621086197 no 199 0.014172516276398 248 17217104 SGTC_425 3825-7017 13.1 µM 2.18805624969803 0.0246254064572161 no 200 0.0143327526165203 193 3397440 SGTC_985 1493-0307 8.71 µM 2.17316521178534 0.0254038498358018 no 201 0.0148839425239382 125 3278274 SGTC_1398 3558-0053 112 µM 2.17022489156909 0.0255599698241666 no 202 0.0149949066408796 113 4532369 SGTC_2180 6301957 200 µM 2.16508868500939 0.0258346103742449 no 203 0.0151904471604289 114 845462 SGTC_1391 3442-0225 151 µM 2.16224747446082 0.025987592031376 no 204 0.0152995529998821 149 5227075 SGTC_679 0422-0091 41.4 µM 2.16209729256959 0.0259956994416488 no 205 0.0153053388420614 212 627384 YHR062C RPP1 SGTC_790 1575-0012 79.1 µM 2.15731506237827 0.0262549715438298 no 206 0.0154905620923667 196 378741 YLR208W SEC13 SGTC_2179 6298986 200 µM 2.15270867477454 0.0265067508067512 no 207 0.0156707906554849 146 738374 SGTC_3076 9116187 49.47 µM 2.15190205920637 0.0265510462902727 no 208 0.0157025345228273 162 27241210 SGTC_54 0159-0055 9 µM 2.14830408699029 0.0267493836326838 no 209 0.0158448032196797 176 3319099 SGTC_851 0394-0702 453 µM 2.14749962379646 0.0267938983108129 no 210 0.0158767635542433 163 762646 SGTC_832 4083-0019 164 µM 2.13142057520488 0.0276966805160858 no 211 0.0165272546546957 370 1990758 SGTC_2941 9056145 11.23 µM 2.12755681068832 0.0279173548403797 no 212 0.0166869231672168 122 2119517 SGTC_758 0868-0029 16 µM 2.12612810825607 0.0279993235150578 no 213 0.0167462970392032 162 762687 SGTC_1934 st074720 32.6 µM 2.12352858449385 0.0281489796205755 no 214 0.0168547914051134 242 17250992 SGTC_945 3381-0768 11.3 µM 2.1205475181022 0.0283214205136004 no 215 0.0169799493355548 200 1126236 YIL048W NEO1 SGTC_3034 9090421 49.47 µM 2.11877570205573 0.0284243277877067 no 216 0.0170547135659705 137 17173761 SGTC_1468 k284-1086 134 µM 2.11130021035973 0.0288619365656536 no 217 0.0173732579922061 255 15996457 SGTC_1874 staurosporine 7.6 µM 2.09740294591005 0.02969035427904 no 218 0.0179789602672598 219 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_2380 9035439 200 µM 2.08495201621593 0.0304492222793399 no 219 0.0185368281688754 216 6462575 SGTC_2820 7989630 71.43 µM 2.08231838650395 0.0306117805211705 no 220 0.0186566987773869 157 2984098 SGTC_676 falcarinol 140 µM 2.06589241502421 0.031641952807931 no 221 0.0194193196123029 229 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_207 4185-0010 4.486 µM 2.06322894219167 0.0318116645867869 no 222 0.0195454407883791 294 3761753 SGTC_2177 5811945 192 µM 2.06082990055837 0.0319651702913926 no 223 0.0196596354095993 201 5343475 SGTC_1876 myriocin 605 nM 2.05831278945622 0.0321268879230846 no 224 0.019780058632426 190 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_1498 4478-3555 97.6 µM 2.05655216573299 0.0322404042484734 no 225 0.0198646617484092 117 3437919 SGTC_540 1187-0821 17.3 µM 2.04161913035099 0.0332165844036414 no 226 0.0205946630873534 207 847520 SGTC_1919 st067113 52.3 µM 2.0370911918284 0.0335173437024962 no 227 0.0208204522085142 242 1268243 SGTC_2218 6965428 192.983 µM 2.03455986481067 0.0336864566808613 no 228 0.0209475896188403 164 675684 SGTC_1466 k213-0079 57.5 µM 2.03323749849927 0.0337750802101176 no 229 0.0210142671373686 212 3657981 SGTC_1562 morin hydrate 59.1 µM 2.01857442686799 0.0347706993798227 no 230 0.0217657356204664 199 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_3003 9075612 71.4286 µM 2.01276886621744 0.0351714981044918 no 231 0.0220694753388044 210 6501993 SGTC_195 4234-0266 16.654 µM 2.01233433656091 0.0352016485916413 no 232 0.022092352605881 258 2303354 SGTC_3142 9086498 49.47 µM 2.01183762777085 0.0352361394393361 no 233 0.0221185280157963 208 25236367 SGTC_3305 9127027 53.8275 µM 1.9953363547813 0.0363978176494604 no 234 0.0230031036825587 227 41905295 SGTC_1709 st033179 39.1045 µM 1.99174873254319 0.0366544876989753 no 235 0.0231993169286335 221 573381 SGTC_2976 9009005 19.48 µM 1.98743770315956 0.0369648691099235 no 236 0.0234369565100797 206 2993148 SGTC_304 1310-0298 97 µM 1.98598007813833 0.0370702986047829 no 237 0.0235177680124938 282 1550234 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 1.97753991167631 0.0376856142743011 no 238 0.0239903168622892 314 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1375 2910-0797 186 µM 1.96606737039037 0.0385353428007152 no 239 0.0246454144742366 228 742508 SGTC_1089 terbinafine 2.25 µM 1.96464861113984 0.0386415015081771 no 240 0.0247274607717995 210 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1176 0848-0131 83.3 µM 1.95702824761299 0.0392157795327437 no 241 0.0251720736787632 270 6769040 SGTC_1243 0416-0003 5.65 µM 1.95428335080774 0.0394243316646984 no 242 0.0253338583579896 272 2141977 SGTC_249 wiskostatin 11.211 µM 1.94991026678379 0.0397584534996329 no 243 0.0255934076141665 194 2775510 A n-wasp and actin depolymerizer. SGTC_3217 9129673 49.47 µM 1.94755690126106 0.0399392110674438 no 244 0.025734002491103 265 17248312 SGTC_607 4491-0986 66.8 µM 1.94664588232576 0.0400093637901365 no 245 0.0257886019149575 236 698981 YDR232W HEM1 SGTC_246 cycloheximide 667 µM 1.93941312949914 0.0405698795364304 no 246 0.026225526531949 182 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_844 0330-0132 15.3 µM 1.93800031076208 0.0406801092781333 no 247 0.0263115923143076 227 2828079 SGTC_660 4031-1742 102 µM 1.93142887346575 0.0411960189961254 no 248 0.0267150186792431 286 6738706 SGTC_988 1497-1057 103 µM 1.93050415568777 0.0412690405404422 no 249 0.0267722004017016 245 3533044 SGTC_825 1988-2224 89.6 µM 1.92891325411693 0.041394913664798 no 250 0.0268708160615853 270 1180859 SGTC_2310 7668677 200 µM 1.92737524853839 0.0415168972477296 no 251 0.0269664409748291 269 2197143 SGTC_1229 0139-0193 12.2 µM 1.92495229114375 0.0417096595654136 no 252 0.0271176635610775 256 3090752 SGTC_3283 9109332 35.8195 µM 1.91990809293372 0.0421132844327327 no 253 0.0274347547502755 188 17027281 SGTC_1800 st050079 29.0735 µM 1.91924242601807 0.0421667848519673 no 254 0.0274768302807044 444 3645560 SGTC_506 n9-isopropylolomoucine 153 µM 1.91764528415931 0.0422953733005325 no 255 0.027578002004803 227 6610355 SGTC_2161 5662504 8.5105 µM 1.91457917922971 0.0425431193679218 no 256 0.0277730962505778 238 2859334 SGTC_168 3970-0862 530.542 µM 1.91422662204657 0.0425716816110937 no 257 0.0277956027713287 474 3135186 SGTC_715 0868-0130 184 µM 1.91123155831776 0.0428149510626058 no 258 0.0279874150086606 206 2876258 SGTC_2184 6075246 200 µM 1.90013779199385 0.0437258295408926 no 259 0.0287075196655138 249 2267320 SGTC_1308 1187-1617 41.4 µM 1.8983787900197 0.0438716820914578 no 260 0.0288231007879277 288 2882570 SGTC_652 0437-0092 114 µM 1.89157144363995 0.044439834020944 no 261 0.0292740518305629 220 3091274 SGTC_159 3970-0959 50 µM 1.88278684144426 0.0451817561136341 no 262 0.0298646305060457 475 6615653 SGTC_2604 4'-hydroxychalcone 11.32 µM 1.8825053783775 0.045205691453587 no 263 0.0298837151594433 253 5282362 SGTC_927 2425-1185 123 µM 1.87778166208807 0.0456089160146426 no 264 0.0302055199475218 259 730375 SGTC_2608 thymoquinone 42.66 µM 1.87730803515199 0.0456495046259593 no 265 0.0302379437928244 226 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_1597 7-benzyloxygramine 47.5 µM 1.87211568691318 0.046096382271303 no 266 0.0305953000983996 450 260807 SGTC_2819 7996655 46.38 µM 1.85997809938833 0.04715471139056 no 267 0.0314443122701939 227 6456960 SGTC_782 0083-0095 30.5 µM 1.85576644474411 0.0475264638884162 no 268 0.0317434276742704 312 3591729 An indicator and reagent. SGTC_1948 st076329 66.6 µM 1.85553410861654 0.0475470397697909 no 269 0.0317599965776218 247 24208413 SGTC_1557 sumaresinolic acid 42.3 µM 1.83361745383329 0.0495203013422197 no 270 0.0333553997580379 260 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_37 0566-0070 1.56 µM 1.83272294603975 0.0496022059464964 no 271 0.0334218915605901 305 1626686 SGTC_235 0330-0087 5 mM 1.82967719586257 0.0498818976229065 no 272 0.0336491114080672 301 46494818 YHR062C RPP1 SGTC_107 0358-0022 2.6945 µM 1.82843764647612 0.049996085146669 no 273 0.033741947852837 171 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_3353 9151644 39.2805 µM 1.82248550891594 0.050547303631456 no 274 0.0341906752686561 271 4909158 SGTC_2639 lactacystin 53 µM 1.81987777370598 0.0507903222539005 no 275 0.0343888101912492 291 3870 A proteasome inhibitor. SGTC_3306 9127676 59.7925 µM 1.81585463506427 0.0511670681834429 no 276 0.0346963368830703 282 41905287 SGTC_129 0088-0017 176.636 µM 1.80997849811106 0.0517213297778012 no 277 0.0351495608276237 313 182446 SGTC_2354 9060492 162 µM 1.80519842534592 0.0521757173811603 no 278 0.035521818636985 315 6471895 SGTC_2840 9008771 71.43 µM 1.79978430290149 0.0526942000631109 no 279 0.0359473517391511 209 2992978 SGTC_595 3909-8003 73.7 µM 1.79943604538665 0.0527276903437187 no 280 0.0359748660229298 286 699517 SGTC_467 ro 31-8220 72.8 µM 1.79170631709734 0.0534753781908325 no 281 0.0365900110528586 354 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_2483 5729050 27.16 µM 1.78280052624592 0.0543472137474577 no 282 0.0373093900408546 375 2865180 SGTC_1977 st070720 65.3 µM 1.78014714789583 0.054609130057699 no 283 0.0375259411402454 247 682188 SGTC_1493 4348-0038 111 µM 1.77791394966288 0.0548303428440139 no 284 0.0377089943898755 320 800424 SGTC_3311 9131146 2.8755 µM 1.77715754321056 0.0549054301919425 no 285 0.0377711613530764 367 4900406 YPR165W RHO1 SGTC_1499 4480-0877 67.3 µM 1.77527097698305 0.0550930609484413 no 286 0.0379265775845772 215 2861909 SGTC_1348 1493-0373 93.8 µM 1.77482557514988 0.0551374327668534 no 287 0.0379633460354411 263 3010129 SGTC_3278 9139605 49.47 µM 1.7687779402065 0.0557427083090755 no 288 0.0384654697580742 296 7958859 SGTC_1726 st035556 14.5795 µM 1.76552311176218 0.0560706303232791 no 289 0.0387379447292711 336 5919439 SGTC_1059 3448-6867 171 µM 1.76451832612753 0.0561721686172891 no 290 0.0388223763500755 294 3934407 SGTC_2891 9063876 19.48 µM 1.7592909031878 0.0567027653843355 no 291 0.0392640554574556 185 6472478 SGTC_1713 st033146 12.748 µM 1.75619933251982 0.0570184208428946 no 292 0.0395271893229235 317 674619 SGTC_2075 5212009 200 µM 1.75537649064494 0.0571026673046786 no 293 0.0395974652971635 242 780898 SGTC_1202 1988-0068 29.6 µM 1.75090364152793 0.0575623340722083 no 294 0.0399812547186091 314 2850480 SGTC_3178 9107506 49.47 µM 1.74976709832021 0.0576795970881577 no 295 0.0400792550916367 292 8897194 SGTC_767 0929-0023 86 µM 1.74933934580732 0.0577237791411692 no 296 0.040116189294608 424 1204563 SGTC_104 0074-0074 590.992 µM 1.74642194557924 0.0580258240243075 no 297 0.0403688296571788 172 3943124 SGTC_2786 7743617 45.45 µM 1.7450938402043 0.0581637364816276 no 298 0.040484267818005 252 583674 SGTC_1771 st048882 4.1505 µM 1.74438522106639 0.0582374258479361 no 299 0.0405459701480817 299 4580403 SGTC_2185 6113692 200 µM 1.74299796944337 0.058381898579205 no 300 0.0406669847553922 273 874150 SGTC_891 0929-0073 133 µM 1.73932320555493 0.0587659605289396 no 301 0.0409889638679896 282 5603632 SGTC_712 r015-0009 80.6 µM 1.73774764077592 0.0589312342507641 no 302 0.0411276451054652 266 6813872 YLR060W FRS1 SGTC_2513 baicalein 25.65 µM 1.73070348978981 0.0596746163685034 no 303 0.0417523312568495 307 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_1427 4048-4900 550 nM 1.72232277054325 0.0605685976893217 no 304 0.0425055325308037 310 24132586 SGTC_1487 3970-0795 2.82 µM 1.71997576853157 0.0608208239788344 no 305 0.0427184231621869 320 3765103 SGTC_418 lividomycin a 100 µM 1.71958342299205 0.0608630683605708 no 306 0.0427540957833454 301 72394 An antibiotic. SGTC_2247 cerulenin 830 nM 1.71290053603811 0.0615861528960984 no 307 0.0433654198298116 327 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_682 0kpi-0099 17 µM 1.71244199027167 0.0616360121814942 no 308 0.0434076232033864 374 1714895 YML126C ERG13 SGTC_2226 7298446 200 µM 1.70528478415474 0.0624183321181386 no 309 0.0440706619990982 262 3283010 SGTC_81 0411-0046 9.971 µM 1.70234251933328 0.0627421739633708 no 310 0.0443455892675907 293 12925265 SGTC_1254 0550-0035 264 µM 1.69995532206788 0.0630058829175063 no 311 0.0445696648364136 344 15121435 SGTC_548 1436-0017 110 µM 1.69772673475073 0.0632528490097364 no 312 0.044779674723473 395 9677137 SGTC_1024 4507-0395 26 µM 1.69602771323362 0.063441635866877 no 313 0.0449403159260048 316 4201836 SGTC_417 st075190 100 µM 1.69110662583506 0.063990917891825 no 314 0.0454082199855977 337 222757 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 1.68639728630114 0.0645200208923161 no 315 0.0458596518916616 407 91467 include heat shock SGTC_273 hydroxyurea 18.1 mM 1.67066644724027 0.0663120705051797 no 316 0.0473937898754302 394 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_462 ag-879 158 µM 1.66995923448136 0.0663935322325355 no 317 0.0474637146883423 372 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_2020 4017018 200 µM 1.66762741968541 0.0666626760189373 no 318 0.0476948558036262 344 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_3347 9188721 44.724 µM 1.66675103695362 0.0667640482970337 no 319 0.0477819599481452 293 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_210 3551-0445 56.827 µM 1.66135964140084 0.0673903037955733 no 320 0.0483206191374198 369 2865180 YOR207C RET1 SGTC_507 nimesulide 162 µM 1.66075853441834 0.0674604077873696 no 321 0.0483809760675155 333 4495 A COX2 inhibitor. SGTC_2053 5265679 138 µM 1.66018927278331 0.0675268497694592 no 322 0.0484381909954505 363 764595 SGTC_2044 5102272 200 µM 1.6578326230099 0.0678024467808816 no 323 0.0486756273274133 291 592666 SGTC_1590 st077108 57.8 µM 1.6508702120928 0.0686217374983909 no 324 0.0493825397299799 302 5489485 SGTC_361 000s-0510 1.45 µM 1.64961467315907 0.0687702903010423 no 325 0.0495108859824198 378 660 SGTC_1651 st011928 86.1 µM 1.64246610682324 0.0696208235123301 no 326 0.0502467223203034 321 720198 SGTC_212 3807-4682 38.772 µM 1.6416083666646 0.0697234188707923 no 327 0.0503355963156176 489 3125501 YBL034C STU1 SGTC_2113 5491891 107.031 µM 1.63944577265001 0.0699826060079914 no 328 0.0505602277469374 366 789979 SGTC_634 1611-4317 11.2 µM 1.63885752821036 0.0700532352621279 no 329 0.0506214674057693 379 2843522 SGTC_3136 9095672 49.47 µM 1.63358674613274 0.0706885360221957 no 330 0.0511728263285126 300 17217380 SGTC_1275 0867-0008 21.1 µM 1.63030693448822 0.0710860890488169 no 331 0.0515183213528511 361 3422836 SGTC_2115 tiliquinol 12.7705 µM 1.61633078995228 0.0727994376129061 no 332 0.0530114066155682 309 71208 A bioactive hydroxyquinoline. SGTC_1696 st025591 34.7925 µM 1.60966791097926 0.0736272948140301 no 333 0.0537351869390279 390 2787147 SGTC_1859 st055998 20 µM 1.60965575450904 0.0736288117958603 no 334 0.05373651459826 379 676301 SGTC_2549 cedrol 20.94 µM 1.60926031210545 0.0736781713021636 no 335 0.0537797166956129 307 6708665 A sedative which affects the nervous system. SGTC_435 c-PAF 6.7 µM 1.6088961106601 0.0737236536551473 no 336 0.0538195300449393 387 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_1169 aniline yellow 25.8 µM 1.60289825119879 0.0744757713532231 no 337 0.0544785599307429 322 6051 A DNA damaging agent. SGTC_1140 3229-1848 2.98 µM 1.60116238697389 0.0746945339907464 no 338 0.0546704786168634 317 2849525 SGTC_1311 1190-0148 100 µM 1.60095951094835 0.0747201334536573 no 339 0.0546929436152158 459 1961333 SGTC_1720 st037298 9.481 µM 1.59790051033207 0.0751069386506476 no 340 0.0550325602512792 355 597396 SGTC_2748 diazoxide 86.69 µM 1.59778801858053 0.075121192086529 no 341 0.055045081013201 295 3019 A potassium channel activatior. SGTC_566 0958-0068 16.5 µM 1.59408203682288 0.0755919182288448 no 342 0.0554588308491604 304 6815365 SGTC_2412 st077135 33.4 µM 1.59340919126845 0.075677622217182 no 343 0.0555342125664832 394 13258915 SGTC_1769 st044406 64.4 µM 1.5895164279768 0.0761749182301674 no 344 0.0559719240761099 397 670903 SGTC_1708 st033234 31.827 µM 1.58825748865887 0.0763362774127103 no 345 0.0561140630855654 387 674664 SGTC_3175 9106517 49.47 µM 1.58768042721138 0.0764103266790289 no 346 0.0561793105729426 357 41468073 SGTC_558 k064-0027 21.3 µM 1.58670460060694 0.0765356703322699 no 347 0.0562897819438101 374 5088526 SGTC_377 3970-0964 33.1 µM 1.58612836589078 0.0766097603419101 no 348 0.0563550966963127 482 16481235 SGTC_2946 9065502 71.43 µM 1.58429623682022 0.0768456908034824 no 349 0.0565631608897381 225 16489101 SGTC_1728 st035614 33.7865 µM 1.58134974583548 0.0772262799869464 no 350 0.0568990455893043 457 15945546 SGTC_1000 4048-0884 8.67 µM 1.57849056624101 0.0775969588221844 no 351 0.057226476847456 385 13040088 SGTC_978 1416-0512 87.4 µM 1.57520011190708 0.0780252204857356 no 352 0.0576051306944744 433 6814003 SGTC_2110 5483698 200 µM 1.56801634394676 0.0789664356914597 no 353 0.058438659054207 361 2848765 YHR062C RPP1 SGTC_3246 9135460 32.98 µM 1.56553081834493 0.0792940832622358 no 354 0.0587292485314242 301 41446951 SGTC_1262 0737-0114 49.6 µM 1.56462490450885 0.0794137584268066 no 355 0.0588354429294406 456 765919 SGTC_934 2950-0684 338 µM 1.56231346592798 0.0797197288764241 no 356 0.0591070806350438 412 1121253 SGTC_2769 toremifene 3.73 µM 1.55971664331422 0.0800645390511917 no 357 0.0594134286547998 365 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_348 k064-0012 10.7 µM 1.55879412771032 0.0801873031585862 no 358 0.0595225572685701 346 5066323 SGTC_384 k007-0144 5.16 µM 1.55561845059347 0.0806109955694507 no 359 0.0598994243310301 463 6824886 SGTC_1622 st003707 19.4 µM 1.5540025611218 0.0808272323045963 no 360 0.0600919028594718 445 10140899 SGTC_500 h-89 112 µM 1.5526735404253 0.0810054085298489 no 361 0.060250573347956 410 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_571 k831-0106 44.2 µM 1.55232138390967 0.0810526703225417 no 362 0.0602926718859251 364 4783639 SGTC_2462 5162487 171.77 µM 1.54981873171779 0.0813891428608366 no 363 0.0605925148836726 395 2259986 SGTC_946 3434-1334 87.4 µM 1.54862822955505 0.0815495708881304 no 364 0.0607355578910012 396 4047976 SGTC_75 0159-0059 199.013 µM 1.54647417490972 0.0818404498447287 no 365 0.0609950461874861 379 5377270 SGTC_2200 6600604 21.907 µM 1.54191193326959 0.0824591062216845 no 366 0.0615474978510759 438 2904777 SGTC_2207 7258803 200 µM 1.54155421814065 0.0825077621329826 no 367 0.0615909790213093 340 3666799 SGTC_422 cantharidin 155 µM 1.54113966129246 0.0825641766092171 no 368 0.0616413994486012 447 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2046 4110841 106 µM 1.53890435323851 0.082868866315639 no 369 0.0619138241335054 389 44119630 YMR134W ERG29 SGTC_2274 7947094 46.08 µM 1.53840776504881 0.0829366698061686 no 370 0.0619744724172414 427 2971028 SGTC_184 1494-0393 24.714 µM 1.53371148901306 0.0835799579072543 no 371 0.0625503230264353 431 3090647 SGTC_2073 5212005 126 µM 1.53363380176451 0.0835906308118232 no 372 0.0625598838771317 288 691789 SGTC_2899 9053889 58.44 µM 1.53196724526167 0.0838198339743377 no 373 0.0627652589030985 352 6470052 SGTC_1875 nocodazole 6 µM 1.53066926000862 0.0839986739122524 no 374 0.0629255773774677 389 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_2996 9066192 71.4286 µM 1.52776201711263 0.0844002810601322 no 375 0.0632858179827407 430 6472854 SGTC_1309 pyrazolanthrone 13.4 µM 1.52531524837911 0.0847393932983604 no 376 0.0635902431341556 424 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_2196 6573537 42.6665 µM 1.52457954774648 0.084841557959229 no 377 0.0636820009344446 355 2903087 SGTC_355 1311-2252 105 µM 1.52449877845479 0.0848527797852658 no 378 0.0636920808862074 423 5338538 SGTC_535 2293-4129 48.2 µM 1.5222008013392 0.0851725197642274 no 379 0.0639793872069186 505 396118 YIL048W NEO1 SGTC_2862 9027634 71.43 µM 1.5197709122392 0.0855115950879573 no 380 0.0642842810617428 397 5012562 SGTC_364 0083-0097 67.7 µM 1.51897647367401 0.0856226728536148 no 381 0.0643842089641122 407 5207356 SGTC_84 0443-0269 128.823 µM 1.51720668294716 0.0858705119353217 no 382 0.0646072547798604 423 6150058 SGTC_23 0213-0011 39.996 µM 1.51678760104943 0.0859292781377617 no 383 0.0646601592413084 394 627608 SGTC_465 cgp-37157 41 µM 1.51635120940618 0.0859905035988349 no 384 0.0647152846198751 272 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_791 1348-1292 225 µM 1.51514800833046 0.0861594809856254 no 385 0.0648674630863901 499 5437054 SGTC_3286 9117135 37.221 µM 1.51291089610846 0.0864743207672896 no 386 0.0651511468960617 417 3438150 SGTC_2411 st077133 39.94 µM 1.51216177306273 0.0865799405371808 no 387 0.0652463565806244 481 1403142 YNL221C POP1 SGTC_2963 9082507 9 µM 1.51197735542327 0.0866059565900522 no 388 0.0652698116640898 398 16459611 SGTC_2311 7694451 200 µM 1.50883922614708 0.0870495529817503 no 389 0.0656699368726664 419 2163142 SGTC_2434 5670830 169.91 µM 1.50833060688363 0.0871216093793381 no 390 0.0657349667608935 430 1549830 SGTC_2890 9046729 58.44 µM 1.50476150291712 0.0876284999136759 no 391 0.0661927022517669 370 903329 SGTC_1878 temozolomide 1 mM 1.50396090420811 0.0877425039394892 no 392 0.0662957167789781 370 5394 DNA alkylating agent. SGTC_1434 4073-0095 163 µM 1.50293605584885 0.0878886021967338 no 393 0.0664277670636247 419 24133745 SGTC_3271 9137798 49.47 µM 1.50091223244019 0.0881776430795124 no 394 0.0666891319313297 338 6498326 SGTC_673 1082-0474 110 µM 1.50084140326896 0.0881877716646578 no 395 0.0666982934943058 519 3098046 SGTC_1320 1313-0481 95.3 µM 1.50001017116463 0.0883067028329435 no 396 0.0668058839341198 422 6813365 YLR208W SEC13 SGTC_2233 sulbentine 40.3845 µM 1.49958614150127 0.0883674182432835 no 397 0.0668608198661913 482 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_1173 0443-0020 122 µM 1.49945937622604 0.088385575383948 no 398 0.0668772499554599 435 5331295 SGTC_1084 voriconazole 435 nM 1.49655360401825 0.0888025443320178 no 399 0.0672547250668537 415 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1270 0831-1170 17.3 µM 1.49445077734554 0.0891052054918523 no 400 0.0675289191111763 460 6764716 SGTC_1087 pterostilbene 9.05 µM 1.49319809880919 0.0892858688087276 no 401 0.0676926698175445 467 5281727 Similar to reservatol, lowers cholesterol. SGTC_1910 st062352 60.4 µM 1.49148597285196 0.089533234968195 no 402 0.0679169756328976 437 2245730 SGTC_797 k781-0471 270 µM 1.48242125833014 0.0908513927741452 no 403 0.0691141204910035 436 23738129 SGTC_2126 5251174 33.877 µM 1.47397430959589 0.0920926276383263 no 404 0.0702442541695147 536 790722 SGTC_1397 3532-0190 20.1 µM 1.47106610738712 0.092522865177552 no 405 0.0706366198910219 348 5322280 SGTC_1537 2',6'-dihydroxyflavanone 78 µM 1.47054944102559 0.0925994557683312 no 406 0.0707065027960486 477 5106787 A p450 inhibitor. SGTC_3040 9091894 49.47 µM 1.46573697254993 0.0933151098743153 no 407 0.0713599787731574 380 25236966 SGTC_2518 prenyletin 46.28 µM 1.4606967672846 0.0940690025634761 no 408 0.0720493383091325 337 3873459 A coumarin with calcium channel inhibitory activity. SGTC_2879 9041815 71.43 µM 1.45954075101008 0.0942425464282426 no 409 0.0722081665324716 312 4942971 SGTC_2647 atorvastatin 60.16 µM 1.45751436767726 0.0945473214277512 no 410 0.0724872241326099 420 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_3237 9133362 49.47 µM 1.45715116759378 0.0946020246686465 no 411 0.0725373283884673 416 43845137 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 1.45634442093145 0.0947236159667996 no 412 0.0726487157781927 448 16623 A steroid. SGTC_2420 aureobasidin a 50 nM 1.45598041391485 0.0947785160938601 no 413 0.0726990170380585 494 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_2709 st078560 56 µM 1.45485787290169 0.0949479671934616 no 414 0.0728543062466587 428 17250903 SGTC_2217 6934799 96.0675 µM 1.45266564270572 0.0952795345930275 no 415 0.0731583053416768 419 675606 SGTC_2827 7993847 71.43 µM 1.45148097356124 0.0954590662316191 no 416 0.0733229882565781 388 2985692 SGTC_268 camptothecin 39.6153 µM 1.45117235495995 0.0955058769414446 no 417 0.0733659363880373 565 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1533 dihydroergotamine mesylate 29.4 µM 1.44502614427669 0.0964416444183504 no 418 0.0742252710980978 469 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_43 0570-0105 72.5 µM 1.44400316043249 0.0965980466077026 no 419 0.0743690431679064 566 1114046 YDL195W SEC31 SGTC_3016 9080866 49.47 µM 1.43433094600553 0.0980860319362009 no 420 0.0757389216294389 479 17066299 SGTC_3344 9148862 3.898 µM 1.4287329232216 0.0989548750189784 no 421 0.0765405056029922 444 4905352 SGTC_958 1222-0007 33 µM 1.42518837457161 0.0995079112578021 no 422 0.0770513779624396 502 7312461 SGTC_2485 5633444 17.78 µM 1.42399034287094 0.099695343327647 no 423 0.0772246338027009 463 5724239 SGTC_1561 5-methoxyflavone 52.9 µM 1.42176569118432 0.100044074067288 no 424 0.0775471413019374 375 94525 SGTC_491 tetrandrine 80.3 µM 1.41768502325898 0.100686063013554 no 425 0.0781413722752128 404 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_550 4123-0385 25.7 µM 1.41495109598321 0.101117854340159 no 426 0.0785414175685621 456 5731123 SGTC_2298 7976326 193.81 µM 1.41078821751217 0.10177792102901 no 427 0.079153534853842 387 2235818 SGTC_2997 9067075 71.4286 µM 1.40992750445538 0.101914786256626 no 428 0.0792805451341903 516 27209819 SGTC_234 nsc-17383 10.7 µM 1.40820995309893 0.102188300816749 no 429 0.079534454956126 523 408974 SGTC_1851 st056236 18.9 µM 1.40425645031587 0.102819911832105 no 430 0.0801212487324356 482 5393171 SGTC_2021 4019055 173 µM 1.40210903364755 0.10316416936227 no 431 0.0804413449397079 662 44827708 YER133W GLC7 SGTC_2149 5554786 194.827 µM 1.39773680715264 0.10386767702691 no 432 0.0810960584777623 528 745063 YPR165W RHO1 SGTC_1263 0774-1208 64.8 µM 1.39728226953504 0.103941013028635 no 433 0.0811643527360719 565 906585 SGTC_1751 st044839 27.194 µM 1.39547744933268 0.104232576869265 no 434 0.0814359552073825 441 5291326 SGTC_221 trifluoperazine 10.304 µM 1.38919074695293 0.105252804880958 no 435 0.0823873773336743 667 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_1799 st045822 46.1415 µM 1.38304538501574 0.106257060163447 no 436 0.0833254751166854 463 3674992 SGTC_1625 st003711 30.1 µM 1.3826236831262 0.106326226216612 no 437 0.0833901416909021 475 24207034 YER133W GLC7 SGTC_1237 0330-0133 46.1 µM 1.37735900395935 0.107192458310071 no 438 0.084200640557553 458 X1237 YHR072W ERG7 SGTC_336 4111-0029 111 µM 1.37277089799482 0.107951509440527 no 439 0.0849117902975647 427 3131175 SGTC_2033 5192550 145 µM 1.37129974757691 0.108195712495685 no 440 0.085140767181241 470 182073 SGTC_3255 9139072 49.47 µM 1.36994406190447 0.108421100844884 no 441 0.0853521819574353 498 17646060 SGTC_2373 9071805 200 µM 1.3682512636723 0.10870300957491 no 442 0.0856167201307446 485 10149009 SGTC_1103 duloxetine 36.1 µM 1.36362173264067 0.109476675827496 no 443 0.0863433242829541 564 60835 A selective serotonin reuptake inhibitor. SGTC_281 1672-3440 14.9 µM 1.36017554693998 0.110055148775769 no 444 0.0868871893848448 542 6833000 SGTC_426 0988-0037 14.6 µM 1.35678498523014 0.110626421698411 no 445 0.0874247698427189 572 5383008 SGTC_1926 methyl fluorone black 53.6 µM 1.35540154596709 0.110860125699034 no 446 0.0876448286812635 468 72721 Reacts with homocysteine. SGTC_1137 ixabepilone 100 µM 1.35473387333338 0.110973041905399 no 447 0.0877511807738184 572 154225 A novel microtubule stabilizer. SGTC_1646 st011709 75.6 µM 1.35189933469231 0.11145333380013 no 448 0.088203760209357 471 5757843 SGTC_887 0885-0007 9.62 µM 1.34791019933995 0.112131780979298 no 449 0.0888436336160245 548 5719458 SGTC_1672 st016598 6.51 µM 1.34219419421368 0.113109061095907 no 450 0.0897665192299165 536 4665860 YNL267W PIK1 SGTC_1388 3346-4487 254 µM 1.34116906762936 0.113284970435854 no 451 0.0899327834288982 568 3345614 SGTC_2861 9024595 19.48 µM 1.3402401349935 0.113444541587325 no 452 0.0900836435874084 379 16482810 SGTC_967 1306-0166 352 µM 1.33839332586306 0.113762260656393 no 453 0.0903841267021756 528 4437607 SGTC_442 cape 100 µM 1.33659225684704 0.114072721098945 no 454 0.0906778839549195 472 5281787 SGTC_1913 st060213 96.1 µM 1.33470804546305 0.114398158739452 no 455 0.0909859596660231 564 688959 SGTC_1896 st058441 89 µM 1.33094555367695 0.115049986199712 no 456 0.0916034633360829 484 688759 SGTC_1972 st070201 17.4 µM 1.3240551413591 0.116250544088955 no 457 0.092742366103912 539 2829099 SGTC_3260 9137109 49.47 µM 1.32400889924853 0.116258631047109 no 458 0.0927500445864292 415 17478346 SGTC_2397 5161689 200 µM 1.3235501941179 0.116338872388237 no 459 0.0928262378394674 563 2259942 SGTC_1521 st012942 49.4 µM 1.32139789597752 0.116715898854972 no 460 0.0931843636190087 571 24207259 SGTC_319 1348-1596 45.5 µM 1.31738132982016 0.117421811522907 no 461 0.0938554179583479 559 5380505 SGTC_612 0302-0167 22.4 µM 1.31715884173593 0.117461002049084 no 462 0.0938926934024588 605 235821 SGTC_404 fumagillin 50 µM 1.31295247328974 0.118203682987021 no 463 0.0945994817583443 564 12015870 A methionine aminopeptidase binder. SGTC_3236 9132701 49.47 µM 1.3123287666498 0.118314087357904 no 464 0.094704615041589 522 24282524 SGTC_2164 5685496 200 µM 1.31119278772635 0.11851535800653 no 465 0.0948963192078543 570 759046 SGTC_443 clozapine 122 µM 1.31101809584762 0.1185463310454 no 466 0.0949258249961363 443 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1054 3429-0080 167 µM 1.31019907863481 0.11869161986534 no 467 0.0950642486797444 565 1162877 SGTC_3069 9117009 49.47 µM 1.31017381043747 0.118696104294046 no 468 0.0950685216696322 414 41904981 SGTC_2515 chrysin 20.77 µM 1.30975427923076 0.118770577347325 no 469 0.0951394873571649 547 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_2650 prasterone 100 µM 1.3055395573934 0.119520585251325 no 470 0.095854593251383 447 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_146 3448-8650 53.125 µM 1.29719001001685 0.121016234823117 no 471 0.097282908586225 714 2891488 YIL048W NEO1 SGTC_2698 st077697 67.5 µM 1.29677775150486 0.121090422074705 no 472 0.0973538339767633 524 3154499 SGTC_2162 5663267 200 µM 1.29561436033555 0.121299950591062 no 473 0.0975541895869237 573 6456493 SGTC_3042 9091578 49.47 µM 1.29471561116449 0.121461991143259 no 474 0.0977091762868247 493 25236497 SGTC_2612 dictamnine 15.46 µM 1.28830596289014 0.122622035803292 no 475 0.0988197391289758 546 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_2802 7925815 54.55 µM 1.28696027330869 0.122866568217554 no 476 0.0990540676000605 577 1262923 SGTC_2435 5706476 10.6 µM 1.28568234427561 0.123099103865941 no 477 0.0992769727535562 603 5725375 SGTC_2646 retinol 96.75 µM 1.28541924506276 0.123147016423383 no 478 0.0993229098155472 528 445354 A vitamin A analog and teratogen. SGTC_1138 3761-0006 1.03 µM 1.28394377644035 0.123415953720163 no 479 0.099580814264179 528 12061087 SGTC_1501 4491-0275 38.4 µM 1.28225830330333 0.123723672181995 no 480 0.0998760248644622 545 5104718 SGTC_2398 5228213 48.84 µM 1.27964763403626 0.124201364307017 no 481 0.100334544577966 659 80771 YMR134W ERG29 SGTC_2479 5617353 43.85 µM 1.2755354464292 0.124956413531455 no 482 0.101059893108278 565 2731746 SGTC_2809 7964133 12.99 µM 1.27258545304968 0.125500040774653 no 483 0.101582591643344 583 1253665 SGTC_1356 1502-0781 85.8 µM 1.27155621250813 0.125690097907318 no 484 0.101765421479509 561 567702 SGTC_1414 3917-0015 5.4 µM 1.27062708870773 0.125861840089344 no 485 0.10193067263792 522 6618702 SGTC_3012 9080433 71.4286 µM 1.26010192673704 0.127818776547835 no 486 0.103816297657706 594 17688859 SGTC_1971 st069429 63.5 µM 1.25544415628247 0.128691507323186 no 487 0.104658784167781 536 1246522 YGL099W LSG1 SGTC_3049 9092223 49.47 µM 1.25053216859221 0.129616341017521 no 488 0.105552605886911 550 8623917 SGTC_2662 daunorubicin 22.37 µM 1.24905660631063 0.129895058285033 no 489 0.105822185273347 540 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_871 0574-0004 149 µM 1.24742460144046 0.130203808756291 no 490 0.106120925307989 623 9551173 SGTC_2717 st081029 62.2815 µM 1.24609262682604 0.130456174135468 no 491 0.106365195700924 555 5292846 SGTC_2533 agelasine 13.65 µM 1.24373852529224 0.130903025825972 no 492 0.106797906072916 629 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_581 0958-0271 211 µM 1.2433055670149 0.130985324274666 no 493 0.106877626774635 679 4591145 SGTC_1132 3456-3614 2.5 µM 1.24246983710475 0.131144284262908 no 494 0.107031631309566 692 3125502 SGTC_2694 st077685 81.9 µM 1.24102621059977 0.131419182994383 no 495 0.107298033209205 579 2838096 SGTC_1555 citronellol 128 µM 1.24014716001309 0.131586768603474 no 496 0.107460484184955 543 8842 A terpine precursor. SGTC_1424 4048-1941 275 µM 1.23932889142317 0.13174289899551 no 497 0.107611861716867 643 X1424 SGTC_2983 9022671 12.99 µM 1.22954912165923 0.133618831174596 no 498 0.109432996230782 564 6405161 SGTC_1511 0906-3109 28.5 µM 1.22605581948534 0.134293338854645 no 499 0.110088835026789 701 2882180 SGTC_3292 9120825 59.784 µM 1.22600021256205 0.134304094645663 no 500 0.11009929752047 617 24824900 SGTC_1181 1222-0449 220 µM 1.22410531278957 0.134670969976832 no 501 0.110456251059897 609 658318 SGTC_3004 9076122 71.4286 µM 1.22398089522675 0.1346950827487 no 502 0.11047971732958 606 44782551 SGTC_1452 4194-0072 190 µM 1.22328594253907 0.134829822692359 no 503 0.1106108573844 669 1343545 SGTC_2834 9001755 58.44 µM 1.22321304849917 0.134843961009371 no 504 0.110624619212521 542 2989575 SGTC_2797 7859098 81.82 µM 1.2224959938104 0.13498309307549 no 505 0.110760058977093 605 972681 SGTC_439 amiodarone 34.4 µM 1.21868131211367 0.135724921117446 no 506 0.111482586807971 650 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_636 0kpi-0074 126 µM 1.21558285667435 0.136329518674115 no 507 0.112071933973318 570 616434 SGTC_3265 9137266 49.47 µM 1.20844071027243 0.137730167041231 no 508 0.113438894292436 537 17224265 SGTC_2687 chenodiol 100 µM 1.20812643090393 0.137792025207636 no 509 0.11349931725298 582 5702181 A cholesterol synthesis inhibitor. SGTC_2828 7998861 71.43 µM 1.20736823114067 0.137941336210105 no 510 0.11364518225654 515 2988188 SGTC_3006 9075424 71.4286 µM 1.20592047096686 0.138226747654554 no 511 0.113924078310252 577 7465181 SGTC_3180 9109287 49.47 µM 1.19817600386966 0.139760326696809 no 512 0.115424252550574 565 18891271 SGTC_2270 7924575 90.91 µM 1.19678846089408 0.140036308642407 no 513 0.115694508500242 662 1262135 SGTC_1540 guanosine 70.6 µM 1.19629837546417 0.140133874942998 no 514 0.115790071251983 588 6802 Guanosine is a purine nucleoside SGTC_1007 4101-0031 70 µM 1.19365928296284 0.14066005977342 no 515 0.116305636968992 644 1146276 SGTC_959 1222-0044 107 µM 1.19212161679814 0.140967258618347 no 516 0.116606781031793 626 6083612 SGTC_2543 pimpinellin 60.67 µM 1.19160821753962 0.141069928084073 no 517 0.116707450675871 598 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_264 promethazine 12.5 mM 1.190944126027 0.141202808156152 no 518 0.116837760121898 753 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_2572 astragaloside iv 100 µM 1.18664812371575 0.142064458006113 no 519 0.11768322264777 613 45006101 An anti-inflammatory agent. SGTC_53 0973-0023 39.979 µM 1.18638700785061 0.14211694454799 no 520 0.117734750049447 609 674768 SGTC_274 sirtinol 40.1 µM 1.18485252712139 0.142425653589189 no 521 0.11803788003408 636 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_1603 st002045 67.8 µM 1.18349407383826 0.142699327444097 no 522 0.118306696895358 644 5887985 SGTC_1654 st012436 41.8 µM 1.18326036131839 0.142746446964974 no 523 0.118352988585234 585 4323132 SGTC_3315 9136395 68.55 µM 1.18079101750951 0.143244941839972 no 524 0.118842876653253 671 16876844 SGTC_2111 5486399 200 µM 1.17903641916731 0.143599862296088 no 525 0.119191837095788 705 689674 SGTC_3124 9127567 49.47 µM 1.17609254643731 0.144196681697211 no 526 0.119778948037311 611 17592030 SGTC_516 3992-2719 87.3 µM 1.17575317146604 0.144265591465226 no 527 0.119846762113687 582 5350887 YDR037W KRS1 SGTC_1403 3909-7815 62.9 µM 1.17445104673784 0.144530192620837 no 528 0.120107204488258 590 6615483 SGTC_1390 3413-2614 145 µM 1.17371790076823 0.144679316971601 no 529 0.120254018876152 655 3421432 SGTC_845 0330-0138 4.51 µM 1.17235819534846 0.144956159871772 no 530 0.120526638012679 638 9039800 SGTC_3100 9120536 49.47 µM 1.16319818927531 0.146830473776386 no 531 0.122374550518563 517 16421196 SGTC_1021 4476-0760 85.3 µM 1.16260746146316 0.146951903611815 no 532 0.122494401043147 639 746768 SGTC_1064 honokiol 6.76 µM 1.16147836009899 0.147184188702429 no 533 0.122723709246427 669 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_2628 lathosterol 100 µM 1.15671800860205 0.148166220341833 no 534 0.123693794811525 658 6710616 SGTC_230 MPP+ 141.667 µM 1.15301274574646 0.148933621164721 no 535 0.124452576510497 628 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_2909 7941780 10.49 µM 1.15166528896284 0.149213351634858 no 536 0.12472932057297 673 1243215 SGTC_3128 9127691 49.47 µM 1.14914930065311 0.149736606511 no 537 0.125247211187743 553 41316314 SGTC_1240 0356-0016 42.1 µM 1.14732671032053 0.150116417741943 no 538 0.125623309387971 669 4305613 SGTC_637 1181-0519 7.26 µM 1.14730080632354 0.15012182052378 no 539 0.125628660446074 761 6252091 YGR060W ERG25 SGTC_2306 7482397 179.52 µM 1.14454535560996 0.150697263574403 no 540 0.126198769701538 663 891448 SGTC_2129 girgensonine 121.053 µM 1.14140404380855 0.151355078558492 no 541 0.126850911338862 717 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_3214 9129694 49.47 µM 1.14132053299341 0.151372592388048 no 542 0.12686828028099 636 17158655 SGTC_666 0272-0154 136 µM 1.13789049096466 0.152093102898708 no 543 0.127583106201422 700 6870312 SGTC_1122 capsaicin 818.572 nM 1.137061756631 0.152267526894806 no 544 0.127756234883812 682 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_3264 9137442 49.47 µM 1.13694384183581 0.152292355249078 no 545 0.127780881412666 632 17015726 SGTC_124 0136-0217 7.121 µM 1.13476567617474 0.152751477126768 no 546 0.128236755601184 778 3976905 SGTC_2876 9059903 25.97 µM 1.13412881308644 0.152885890774021 no 547 0.128370259528654 728 6916095 SGTC_2275 7947463 200 µM 1.13351411309101 0.153015701131403 no 548 0.128499208951008 641 1225414 SGTC_2532 xanthone 78.9 µM 1.13326452139224 0.153068429949927 no 549 0.12855159300192 613 7020 An insecticide. SGTC_2886 9058944 51.95 µM 1.13282583420743 0.153161136323364 no 550 0.128643700133901 501 4949929 SGTC_109 0132-0036 33.701 µM 1.13212879324115 0.15330851630371 no 551 0.128790145616043 546 67274 A color developer. SGTC_1145 3546-0597 10.2 µM 1.13024923723915 0.153706391384203 no 552 0.129185608949129 702 875334 SGTC_35 0133-0054 64.071 µM 1.12923095595127 0.153922232194445 no 553 0.129400209116254 630 99677 SGTC_1209 2323-2347 50.3 µM 1.1288217834208 0.154009019241696 no 554 0.129486510712893 671 5412760 SGTC_2456 5770359 74.46 µM 1.12680551505487 0.154437150193536 no 555 0.129912359122741 700 3118787 SGTC_818 4072-2707 53.5 µM 1.12410085563997 0.155012687383642 no 556 0.130485121187514 664 882871 SGTC_1773 st048542 73.5835 µM 1.12405153412701 0.155023195873043 no 557 0.130495582125992 683 3237138 SGTC_2699 st077704 54.6 µM 1.12168593691132 0.155527764673089 no 558 0.130997999009624 677 645852 SGTC_2894 9048625 32.47 µM 1.12101148535703 0.155671819713205 no 559 0.131141486786663 696 4092861 SGTC_2547 epiafzelechin trimethyl ether 100 µM 1.11985199630667 0.155919678760896 no 560 0.131388418677104 511 6708630 An antioxidant. SGTC_627 1391-0720 175 µM 1.11957354287221 0.15597924128587 no 561 0.131447767599766 660 997839 SGTC_196 k015-0023 18.111 µM 1.11737394374951 0.15645027316674 no 562 0.131917235612551 709 5211998 SGTC_827 3253-0474 693 µM 1.11634189882106 0.156671602348405 no 563 0.132137906666721 736 5402065 SGTC_1485 3909-9022 254 µM 1.11578764065931 0.156790551872807 no 564 0.132256522711112 710 714516 SGTC_1762 st045503 25.4615 µM 1.11544872830027 0.156863315237373 no 565 0.132329089041626 696 4645554 SGTC_1571 st070080 73.4 µM 1.11492587276975 0.156975614166755 no 566 0.132441094242385 695 4315245 SGTC_1685 st024049 53.0905 µM 1.11474511909506 0.157014448746359 no 567 0.132479830171362 659 1941139 SGTC_1251 0490-5699 265 µM 1.11456127101626 0.157053954635033 no 568 0.132519237245719 740 3883818 SGTC_691 1548-0686 185 µM 1.11283670166818 0.157424854130689 no 569 0.132889284764117 711 46495133 SGTC_1748 st037455 53.6035 µM 1.11269499022039 0.157455357289545 no 570 0.132919723940801 699 580690 SGTC_182 3448-4371 550.524 µM 1.1106218124006 0.157902049515895 no 571 0.133365584919349 749 3491403 SGTC_807 1315-0151 48 µM 1.10993737321637 0.158049703073242 no 572 0.133513007163432 775 4011080 SGTC_1350 1495-0454 146 µM 1.10909084153903 0.158232450060589 no 573 0.133695497700295 750 1069057 SGTC_3118 9124250 49.47 µM 1.10747233750206 0.158582234209433 no 574 0.134044882893318 621 1504786 SGTC_1810 st050138 53 µM 1.10347379172836 0.159448554872116 no 575 0.134910733413234 664 3444541 SGTC_2898 9056270 58.44 µM 1.1030534916228 0.159539796257316 no 576 0.135001968097072 621 19154699 SGTC_2281 7943571 200 µM 1.10247014358536 0.159666489731607 no 577 0.135128665760026 754 1244024 SGTC_3153 9100258 49.47 µM 1.10237050501322 0.159688136150528 no 578 0.135150314462945 638 25236848 SGTC_1961 st076550 68.7 µM 1.1014655231878 0.159884830822457 no 579 0.135347050846938 636 1579337 SGTC_544 k015-0020 52.4 µM 1.09716413110157 0.16082188922809 no 580 0.136284824932649 689 3008304 SGTC_47 0149-0135 24.25 µM 1.09606708502577 0.161061453462746 no 581 0.136524708829234 664 5239155 SGTC_714 4296-0578 26.1 µM 1.09501774683 0.161290817425036 no 582 0.136754430819108 665 1589775 SGTC_3089 9117425 49.47 µM 1.09257039485267 0.161826586234869 no 583 0.137291233550831 648 9401657 SGTC_1932 st074806 40.9 µM 1.08997247494355 0.162396584417556 no 584 0.137862634537765 761 17251235 SGTC_2157 5649910 96.377 µM 1.08879999387203 0.16265426076526 no 585 0.138121047168207 722 2858091 SGTC_1219 1469-0211 33.1 µM 1.08714112370782 0.16301928502589 no 586 0.1384872229679 692 6822282 SGTC_324 1315-0088 19.6 µM 1.08532968741182 0.163418488278048 no 587 0.138887830873136 619 6787421 SGTC_2581 avocatin a 64 µM 1.08467115724091 0.163563772010079 no 588 0.13903366339453 736 6710728 A skin care supplement. SGTC_2787 5284540 71.43 µM 1.08205083436548 0.164142693431004 no 589 0.139614970278452 717 736958 SGTC_29 0299-0004 12.984 µM 1.08125538943521 0.164318697813261 no 590 0.139791762713811 611 16871 A napthoquinone isolated from Swertia calycina. SGTC_1465 k213-0056 144 µM 1.07699893264909 0.165262582459879 no 591 0.140740371265973 706 24048857 YMR208W ERG12 SGTC_2215 7188065 200 µM 1.07584725144226 0.165518573862888 no 592 0.140997787976059 694 940217 SGTC_2760 etidronate 98.04 µM 1.07559486353179 0.165574707950792 no 593 0.141054242803364 683 3305 A chelator and antioxidant. SGTC_914 3820-6779 408 µM 1.07472446059288 0.165768390403569 no 594 0.141249054527492 703 2893481 SGTC_2188 6126565 140.678 µM 1.07459008305349 0.165798305200834 no 595 0.141279146866986 685 874518 SGTC_1070 indatraline 8.81 µM 1.07381582309217 0.1659707370274 no 596 0.141452618339614 722 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_1504 k297-0033 30 µM 1.07360634364927 0.166017409129244 no 597 0.141499576609463 592 4388117 SGTC_3297 9117502 71.43 µM 1.07332873510627 0.166079273486458 no 598 0.141561823413352 747 7453720 SGTC_1332 1480-0653 17.5 µM 1.0718898209449 0.166400170485937 no 599 0.141884761364044 722 5749438 SGTC_282 k297-0036 65.7 µM 1.06972946089209 0.1668827107412 no 600 0.142370550682929 697 5061378 SGTC_60 0986-0278 202 µM 1.0666934592374 0.167562359167614 no 601 0.1430551408362 589 3110598 SGTC_2066 5222451 176 µM 1.06652458381227 0.16760021640205 no 602 0.143093285862547 794 2281147 SGTC_2388 9080168 200 µM 1.06562987276808 0.167800877962181 no 603 0.143295494890354 677 15943073 SGTC_2920 7982904 15.77 µM 1.06409108953074 0.168146350618519 no 604 0.143643718501901 657 6456808 SGTC_1946 st076057 65.1 µM 1.05848471744829 0.169408906640738 no 605 0.144917257258256 608 953009 SGTC_3262 9137218 49.47 µM 1.05588358101443 0.169996743884706 no 606 0.145510703158258 598 17650664 SGTC_3231 9132313 49.47 µM 1.05382206207224 0.170463559262548 no 607 0.145982195372808 746 4905967 SGTC_2670 beta-carotene 100 µM 1.05358192807585 0.170517989121993 no 608 0.146037183352246 682 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_1162 k048-0130 20.1 µM 1.05276688137889 0.170702814276135 no 609 0.146223923621126 753 6797406 SGTC_2765 myclobutanil 7.74 µM 1.04875843273446 0.171613660685759 no 610 0.14714465656362 751 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_2606 farnesol 9.78 µM 1.04705496160484 0.172001681703076 no 611 0.147537114963856 767 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2747 doxorubicin 7.63 µM 1.04653123685399 0.172121089547658 no 612 0.147657915392426 573 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2229 7354935 190 µM 1.04615997129969 0.172205769141432 no 613 0.147743590257432 700 318112 SGTC_2474 5321570 43.32 µM 1.04526023665674 0.172411094138581 no 614 0.147951355029839 757 2841384 SGTC_2641 levomentholum 100 µM 1.04330513454841 0.172857798588724 no 615 0.148403496906892 725 16666 SGTC_2967 9089538 49.85 µM 1.04323323311339 0.172874240777758 no 616 0.148420142614717 772 728216 SGTC_1031 k035-0009 16 µM 1.04300444295571 0.17292656640661 no 617 0.148473117516669 821 5180959 SGTC_1623 st003709 20.3 µM 1.04268411954682 0.172999843171712 no 618 0.148547307601075 810 16192618 SGTC_2347 9049783 174.81 µM 1.04254663709264 0.173031299544966 no 619 0.148579157504707 798 6467988 YPL169C MEX67 SGTC_9 0092-0002 10.449 µM 1.03849237433898 0.173960564014731 no 620 0.149520441824969 773 759368 SGTC_1124 fisetin 1.16336 µM 1.03689526942297 0.174327500887882 no 621 0.149892334417458 702 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_1034 k072-0165 12.7 µM 1.03524485966039 0.174707200869702 no 622 0.150277286845386 808 5835461 SGTC_2088 5278280 127.392 µM 1.02967217411008 0.175993151315621 no 623 0.151581961027646 802 791502 SGTC_2948 9070189 9.45 µM 1.02955608458222 0.176020003653033 no 624 0.151609219667357 702 6473636 YDL196W YDL196W SGTC_2964 9083345 53.42 µM 1.02891523045548 0.176168284473695 no 625 0.151759755373788 708 17741579 SGTC_2349 9023730 187.07 µM 1.02754039503083 0.176486660537164 no 626 0.152083037230992 767 4126287 SGTC_3197 9113331 49.47 µM 1.02746709270109 0.176503645660231 no 627 0.152100286536583 771 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_1413 3910-0535 34.4 µM 1.02722528388667 0.176559683303817 no 628 0.152157197543321 809 2876951 SGTC_2408 sulbentine 18.36 µM 1.02630209995493 0.176773728731368 no 629 0.152374603879569 760 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_131 0141-0277 33.849 µM 1.02382913954847 0.177347906445171 no 630 0.152957992163243 772 1547771 SGTC_2342 7990637 118.86 µM 1.02372991661734 0.177370968801502 no 631 0.152981430390995 787 2033102 YER133W GLC7 SGTC_2461 5755302 26.15 µM 1.02251138126599 0.177654347009 no 632 0.153269464360651 809 2788904 SGTC_1281 0884-0031 11.8 µM 1.01546223574199 0.179299272654021 no 633 0.154942769666523 808 1548255 SGTC_2980 9014342 25.29 µM 1.01257980281946 0.179974641479378 no 634 0.155630455532892 728 2996599 SGTC_1847 st056231 15 µM 1.01097399035204 0.180351583529765 no 635 0.156014439324685 836 5393180 SGTC_79 0052-0007 94.094 µM 1.01049185459452 0.180464854787811 no 636 0.156129849979095 793 2801472 SGTC_2348 9022543 33.42 µM 1.00992604617493 0.18059784070601 no 637 0.156265361402854 799 3162678 YDL140C RPO21 SGTC_3207 9114163 49.47 µM 1.00954746828567 0.180686854828717 no 638 0.156356074263765 844 849233 SGTC_1008 4106-0037 6 µM 1.00772070139374 0.181116764736096 no 639 0.156794281994168 789 2905394 SGTC_2154 5570129 200 µM 1.00499169779764 0.181760198876618 no 640 0.157450423784222 833 673366 SGTC_823 0417-1665 178 µM 1.00415187427572 0.181958496691044 no 641 0.157652707451795 811 3429856 SGTC_397 arbidol 50 µM 1.00211471230877 0.182440070008172 no 642 0.158144096509077 851 131410 A RNA synthesis inhibitor. SGTC_2723 salbutamol 83.58 µM 1.00132081647684 0.182627957800848 no 643 0.158335866077298 716 9884233 β2-adrenoceptor agonist SGTC_2365 9042475 200 µM 0.997940219228996 0.183429380719688 no 644 0.159154173880817 781 6464479 SGTC_1984 st072354 53.1 µM 0.997594888852956 0.183511369867463 no 645 0.159237920264624 802 5762938 SGTC_1438 4092-1045 4 µM 0.997133589554482 0.183620928258505 no 646 0.159349835395468 820 1351342 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.995469295327547 0.184016536131139 no 647 0.15975403531612 855 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_702 1488-0190 94 µM 0.991963592902348 0.184851587020065 no 648 0.160607642794328 808 949357 SGTC_2401 5128683 200 µM 0.988793646631242 0.185608685683435 no 649 0.161382056683409 742 708373 SGTC_1945 st075991 56.6 µM 0.988223604984489 0.185745036230565 no 650 0.161521575047869 736 1084980 SGTC_2841 9004761 38.96 µM 0.986417289581271 0.186177506298388 no 651 0.161964192116421 726 2991039 SGTC_2738 aclarubicin 5.55 µM 0.985746608329765 0.18633824029975 no 652 0.162128735892428 737 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_3277 9138724 49.47 µM 0.985536552365361 0.18638859952718 no 653 0.162180293037041 731 15943418 SGTC_1755 st041960 45.185 µM 0.985024043242004 0.186511504841714 no 654 0.162306130531294 813 2257073 SGTC_2127 5253358 187.912 µM 0.974184759112811 0.189122628752381 no 655 0.164982405342634 731 20612 SGTC_453 enantio-paf c16 10 µM 0.974118592689825 0.189138636696539 no 656 0.164998829427577 916 13871343 A lipid and platelet activating factor SGTC_3164 9100705 49.47 µM 0.973965863970785 0.189175590237122 no 657 0.165036744381804 796 17174235 SGTC_2801 7907800 81.82 µM 0.973474251738478 0.18929456866252 no 658 0.165158825576147 822 6620925 SGTC_3031 9088762 49.47 µM 0.971130211329952 0.189862499069482 no 659 0.165741720554015 869 205253 SGTC_99 0109-0120 622.8 µM 0.967399965587642 0.190768446429693 no 660 0.166672063631811 802 759414 SGTC_357 1325-0123 420 µM 0.966713941521993 0.190935346213982 no 661 0.166843527848887 818 1098503 SGTC_1721 st082152 9.2685 µM 0.965753657444753 0.191169119899965 no 662 0.167083731411427 789 5296051 SGTC_1201 1889-3372 45.9 µM 0.964815319405505 0.191397720430334 no 663 0.167318660721236 816 5392199 SGTC_938 3126-1755 342 µM 0.96403009134746 0.191589148568166 no 664 0.167515419810464 879 1777771 SGTC_1274 0865-0114 173 µM 0.963679720216687 0.191674602207729 no 665 0.167603262385558 829 870624 SGTC_3027 9089541 49.47 µM 0.963489374951558 0.191721036180728 no 666 0.167650996841526 817 9943819 SGTC_1067 clotrimazole 1.36 µM 0.962982299506075 0.191844768840186 no 667 0.167778203071456 856 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_2248 tofa 1.1 µM 0.956471286484747 0.193437877015596 no 668 0.169417092152891 816 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1065 prochlorperazine maleate 2.48 µM 0.955391820210261 0.193702777563348 no 669 0.169689794501691 870 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_623 k072-0108 16.9 µM 0.955145423347777 0.19376327423606 no 670 0.169752080452698 830 5382803 SGTC_1804 st050076 49.1 µM 0.954063513252762 0.194029046879498 no 671 0.170025746889677 851 3895976 SGTC_2912 7964298 10.93 µM 0.952961819669708 0.194299907479423 no 672 0.170304707936624 890 2975850 SGTC_1351 1496-0003 46.5 µM 0.952139777246807 0.194502163413548 no 673 0.170513049102269 887 3891978 SGTC_2158 5657123 3.6195 µM 0.952122431110768 0.194506432649925 no 674 0.170517447122191 857 2858827 SGTC_181 1447-1644 8.07 µM 0.950403246877653 0.194929841709003 no 675 0.170953697410713 855 534600 SGTC_2856 9022925 19.48 µM 0.950174797698696 0.194986147439867 no 676 0.171011721057326 834 4944862 SGTC_1163 k060-0048 49.9 µM 0.948498570027633 0.195399588649773 no 677 0.171437850220097 881 6809982 SGTC_379 3970-0972 5.9 µM 0.948265593082418 0.195457094485944 no 678 0.171497131091542 843 2898042 YBL034C STU1 SGTC_2453 5731132 22.18 µM 0.947984773753128 0.195526422946166 no 679 0.171568602843279 904 1362040 SGTC_2591 skatole 100 µM 0.946491780149376 0.195895262744533 no 680 0.171948906410141 835 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_3105 9121040 49.47 µM 0.946286099810418 0.195946108550123 no 681 0.172001340589928 656 41448907 SGTC_287 k060-0039 29.6 µM 0.945230995382406 0.196207064570743 no 682 0.172270479293031 870 5861974 SGTC_2467 5474540 200 µM 0.944766575895319 0.196321994901222 no 683 0.172389029709343 878 5413519 SGTC_796 1234-0020 70.7 µM 0.944264781104522 0.196446220391969 no 684 0.17251717923932 826 46495034 SGTC_1575 cyproterone acetate 48 µM 0.943074328272424 0.196741122181887 no 685 0.172821442827165 838 9880 An androgen receptor antagonist and liver toxin. SGTC_1133 3473-0247 50 µM 0.942902539809359 0.196783700152092 no 686 0.172865377847303 818 711311 SGTC_3029 9088683 49.47 µM 0.942802407273425 0.196808520691512 no 687 0.172890990097008 852 25236615 SGTC_3218 9131285 49.47 µM 0.93945125176912 0.197640287623164 no 688 0.173749554804904 939 17156417 SGTC_416 estradiol valerate 100 µM 0.938267120281824 0.197934699928378 no 689 0.174053576187681 857 13791 A steroid. SGTC_2630 antimycin a 100 µM 0.937727321741824 0.198068998670669 no 690 0.174192279619242 908 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_695 3505-6186 243 µM 0.935091108499377 0.198725663373239 no 691 0.174870674209806 864 1819379 SGTC_2003 4023581 200 µM 0.933696867527998 0.199073490412612 no 692 0.175230140654411 846 16641307 SGTC_2010 4012422 159 µM 0.933579245201438 0.199102850906775 no 693 0.17526048773513 871 952393 SGTC_1885 st057546 99.9 µM 0.932410209808593 0.199394803425565 no 694 0.175562285190815 906 702008 SGTC_1360 1598-0022 39.8 µM 0.932196314668855 0.199448249042106 no 695 0.175617539850436 945 761525 SGTC_1558 st069300 45.6 µM 0.930558233180521 0.199857839533317 no 696 0.176041064048454 817 24208000 SGTC_2337 9009472 200 µM 0.929333414895262 0.200164426824333 no 697 0.176358161648774 881 5742383 SGTC_1807 st050092 58.9 µM 0.927399393750957 0.200649111599306 no 698 0.176859602653989 836 5008496 SGTC_2986 9022445 71.43 µM 0.927056378975682 0.200735147992078 no 699 0.176948631391618 888 6459286 SGTC_3261 9137475 49.47 µM 0.923116829890913 0.201724868837951 no 700 0.177973162478758 703 17027690 SGTC_2652 actinonin 100 µM 0.921824726114418 0.202050115497749 no 701 0.178310003910874 857 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_1970 st070122 35.8 µM 0.920882048497017 0.202287602949682 no 702 0.17855600593993 868 102928 SGTC_174 3553-0389 74.3 µM 0.920623709407734 0.202352715090968 no 703 0.178623459647974 819 738071 SGTC_776 4476-4378 112 µM 0.918482965562666 0.202892753240523 no 704 0.179183036516296 845 2892008 SGTC_290 2043-6722 48.1 µM 0.918076206816748 0.202995462124325 no 705 0.179289485198771 885 773758 YLR208W SEC13 SGTC_1323 1348-1351 11.2 µM 0.91590199193158 0.203544990013208 no 706 0.179859150978375 857 6989654 SGTC_671 0560-0003 407 µM 0.915450593816674 0.203659190991357 no 707 0.179977564109021 862 3238678 SGTC_3293 9120939 62.045 µM 0.911640206302925 0.204624717367353 no 708 0.180979074910474 876 934087 SGTC_2593 nobiletin 86.24 µM 0.911621488499352 0.204629467043964 no 709 0.180984003245457 825 72344 An anti-infammatory. SGTC_226 1,3-diallylurea 8.28947 mM 0.909692066644452 0.205119413111414 no 710 0.181492464611876 855 74537 YKL182W FAS1 SGTC_1214 0358-0031 63.7 µM 0.906891141118109 0.20583190298592 no 711 0.182232183162913 860 4301366 SGTC_1809 st050081 57.6 µM 0.906152761271333 0.206019973813931 no 712 0.182427501129501 893 5036894 SGTC_998 3996-0085 177 µM 0.905399537987769 0.206211930342283 no 713 0.182626880213052 963 715391 SGTC_3318 9139014 38.6185 µM 0.904398587616265 0.20646718331649 no 714 0.182892043417291 874 16643984 SGTC_1668 st014914 51.6 µM 0.90100010806655 0.207335227282966 no 715 0.183794131114596 920 2839556 SGTC_747 3448-8087 38.7 µM 0.899970351932839 0.207598674263705 no 716 0.18406801436537 908 5168703 SGTC_2916 7875993 68.79 µM 0.899934809690589 0.207607770719761 no 717 0.184077472035389 897 1299250 SGTC_2473 5854593 8.94 µM 0.898328180631611 0.208019207064214 no 718 0.184505306447968 877 2872951 SGTC_1410 3909-8106 77.9 µM 0.897576979208166 0.208211744788879 no 719 0.184705558306535 901 1039210 SGTC_2597 laccaic acid a 100 µM 0.895364871033049 0.20877933265658 no 720 0.185296036456395 892 5491415 A textile dye. SGTC_1790 st045711 43.5 µM 0.89431651944781 0.209048639277753 no 721 0.185576281902792 905 585119 SGTC_14 0354-0009 295 µM 0.893045062621059 0.209375532826188 no 722 0.185916520594184 929 1713507 SGTC_1395 3486-0190 4.35 µM 0.892863550250195 0.209422224466202 no 723 0.18596512438753 955 6748079 SGTC_1052 3253-3998 198 µM 0.892703205959059 0.209463475995751 no 724 0.186008066531019 966 5450317 SGTC_1899 st063254 59.6 µM 0.891563561976479 0.209756808164208 no 725 0.186313454093003 819 3093813 SGTC_604 1000-0114 314 µM 0.891505107173656 0.209771860313818 no 726 0.186329126451984 977 1572745 SGTC_1060 3448-7350 82 µM 0.890156259241044 0.21011936588775 no 727 0.186690993879319 904 570178 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.88919459029188 0.210367328369156 no 728 0.186949254838079 911 756377 SGTC_2937 9044753 11.33 µM 0.888386476535396 0.210575830038053 no 729 0.187166448626947 964 6465530 YGL099W LSG1 SGTC_113 0099-0221 2.5 µM 0.883309488703073 0.211888516597517 no 730 0.188534539234738 884 89219 SGTC_2919 7978188 46.38 µM 0.883142192542613 0.211931853367538 no 731 0.188579725048442 951 2980291 SGTC_1343 1487-0095 224 µM 0.882860473543077 0.212004842199928 no 732 0.188655830957283 938 4560101 YGL055W OLE1 SGTC_630 4356-0227 183 µM 0.882483984826718 0.212102407279708 no 733 0.18875756829895 898 779312 SGTC_3327 9140648 26.9345 µM 0.881576387445033 0.212337714289977 no 734 0.189002964414371 936 8029710 SGTC_546 peri-Naphthalide 147 µM 0.879572274855574 0.21285784785934 no 735 0.189545531911237 932 223824 A penicillin ester. SGTC_867 0518-0118 155 µM 0.877892916479363 0.213294269057896 no 736 0.190000916828445 980 6848158 SGTC_3048 9093155 49.47 µM 0.87773710028498 0.213334788032476 no 737 0.190043202950294 903 25236002 SGTC_1604 st002052 72.4 µM 0.876936762001198 0.213542981440154 no 738 0.190260493611164 925 6254834 YHR062C RPP1 SGTC_1569 carminic acid 40.6 µM 0.874961754550734 0.214057249891448 no 739 0.190797357892246 978 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_151 3013-0144 2.285 µM 0.874733466733407 0.21411673976298 no 740 0.190859473015187 930 906558 YHR107C CDC12 SGTC_708 3448-5400 146 µM 0.873775067736345 0.214366595382112 no 741 0.191120380368662 943 3462195 SGTC_2634 4'-methoxyflavone 100 µM 0.871720308701479 0.214902844317355 no 742 0.191680489153391 882 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_2329 6138490 200 µM 0.871679136562054 0.21491359733731 no 743 0.191691722571142 806 720019 SGTC_773 4358-1457 44.6 µM 0.870899733847507 0.21511721463726 no 744 0.191904451069387 992 1186886 SGTC_1843 st055809 45.5 µM 0.870542948754768 0.215210461338814 no 745 0.192001879421506 885 16413835 SGTC_1372 2752-0194 270 µM 0.870065622947955 0.215335248346699 no 746 0.192132271510494 871 823334 SGTC_3071 9117417 49.47 µM 0.868465417958895 0.215753895181266 no 747 0.19256979797155 873 45595590 YGL055W OLE1 SGTC_401 neomycin 50 µM 0.867749047994072 0.21594146520754 no 748 0.192765864321424 913 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_748 act1.228 77.9 µM 0.865478093426883 0.216536702496712 no 749 0.193388217292306 957 4421505 YNR035C ARC35 SGTC_3351 9150312 21.596 µM 0.864673123944585 0.216747919788281 no 750 0.193609112390968 923 4904905 SGTC_969 1313-0238 134 µM 0.864296007874571 0.216846912874284 no 751 0.193712651323431 971 5212874 SGTC_897 1000-0139 31.4 µM 0.863926446905313 0.216943948097854 no 752 0.193814148714078 955 6151020 SGTC_1041 0206-0046 107 µM 0.862454116971878 0.217330785261995 no 753 0.194218835793916 949 50494 SGTC_2605 digitonin 300 nM 0.861550473659928 0.217568403912173 no 754 0.194467467372227 1050 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_750 4073-0104 132 µM 0.859902817713454 0.218002051050943 no 755 0.19492130758258 816 22330957 SGTC_2627 acetyl isogambogic acid 100 µM 0.858044034501718 0.218491862507081 no 756 0.195434074362145 930 6857789 A caspase activator and apoptosis inducer. SGTC_2737 bleomycin 30.5 nM 0.857394391517238 0.218663200485627 no 757 0.195613478909219 1004 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_2953 9074162 66.49 µM 0.856993053751269 0.218769088647584 no 758 0.195724361766903 911 16451992 SGTC_1640 st009078 66.4 µM 0.856309874316632 0.218949405207834 no 759 0.195913200452774 912 690618 SGTC_2713 st079149 53.4 µM 0.854953269402816 0.219307717207036 no 760 0.196288509278954 954 3103253 SGTC_2592 piperlongumine 83.33 µM 0.854594452675816 0.219402545663203 no 761 0.196387849847905 902 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_517 1365-0151 113 µM 0.854294420227133 0.219481856632712 no 762 0.196470939024629 930 768657 SGTC_3251 9135047 49.47 µM 0.85376140545242 0.219622795066488 no 763 0.196618601451544 953 17682963 SGTC_469 w7 172 µM 0.85359701292347 0.219666273812314 no 764 0.196664157090251 967 45115570 A P450 inhibitor. SGTC_2708 st078559 56 µM 0.853553586079387 0.219677760224673 no 765 0.196676192388443 882 17250902 SGTC_2017 5132927 60.65 µM 0.847919102551828 0.221171005316232 no 766 0.198241512624146 999 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_1255 0566-0045 221 µM 0.847368027686995 0.221317361713109 no 767 0.198395009824366 972 2788469 SGTC_3194 9111903 49.47 µM 0.846442467490947 0.221563299832075 no 768 0.19865297803921 959 17087251 SGTC_2488 5268135 45.7 µM 0.84641755355948 0.221569922073426 no 769 0.198659924739227 1007 1270356 YLR208W SEC13 SGTC_1027 k015-0025 8.67 µM 0.843932257606066 0.222231093825055 no 770 0.199353630649402 975 3598955 SGTC_1742 st038235 28.8875 µM 0.843868510159474 0.22224806757115 no 771 0.199371443260009 945 564103 YBR002C RER2 SGTC_593 1203-0218 61.7 µM 0.84347401598381 0.22235312421442 no 772 0.19948169598618 1025 3666956 SGTC_3205 9113483 49.47 µM 0.843053049593123 0.222465261836891 no 773 0.199599387601052 974 17018033 SGTC_1120 ficusin 1.78878 µM 0.841080098614174 0.222991248898694 no 774 0.200151531678322 981 6199 A DNA cross-linker. SGTC_1128 3448-9350 235 µM 0.840211539255383 0.223223030449239 no 775 0.200394894808511 877 619386 SGTC_1038 k292-0204 154 µM 0.838734574562021 0.223617484208347 no 776 0.200809135966425 923 4454212 SGTC_2246 7293507 91.5585 µM 0.837449264705865 0.223961074938712 no 777 0.201170041958584 1023 887656 SGTC_2452 5863136 48.41 µM 0.834093404418281 0.224859580545352 no 778 0.202114175764421 1002 2184096 SGTC_1916 st067606 49.2 µM 0.832992328587709 0.225154829727082 no 779 0.202424527909564 1022 19590279 SGTC_654 1124-0271 80.9 µM 0.831122628131099 0.225656685341811 no 780 0.202952178926137 995 5403748 SGTC_721 1187-1332 279 µM 0.830397177060108 0.225851577572795 no 781 0.203157130572598 892 25730 SGTC_1250 0485-0349 40.2 µM 0.830391034182035 0.225853228261633 no 782 0.20315886656225 971 6842794 YDL195W SEC31 SGTC_2788 5282734 71.43 µM 0.829474621213433 0.226099559389899 no 783 0.203417945892401 1029 743706 SGTC_1630 st005209 31.3 µM 0.829051681146382 0.226213296557416 no 784 0.203537581827977 1059 3367314 SGTC_90 0870-0863 4.608 µM 0.825411262138123 0.227193614708474 no 785 0.204569071587595 1007 1738164 SGTC_780 0109-0199 192 µM 0.825018635329077 0.227299486934367 no 786 0.204680505441278 1050 610414 SGTC_3216 9129716 49.47 µM 0.824339896589995 0.227482575090451 no 787 0.204873227645417 950 8056934 SGTC_756 0508-1999 28.3 µM 0.82409563903845 0.227548483300932 no 788 0.204942608933662 964 6753853 SGTC_2024 5144227 134 µM 0.823346022763088 0.227750819985277 no 789 0.205155624426286 1025 3475211 SGTC_1096 rimcazole 32.2 µM 0.823173229410578 0.227797474784198 no 790 0.205204745082678 935 18528119 A dopamine reuptake inhibitor. SGTC_2945 9067681 61.76 µM 0.822850905142776 0.227884517816545 no 791 0.20529639216288 1019 16456930 SGTC_1669 st015249 58.4 µM 0.821890007201345 0.228144117428152 no 792 0.205569750376721 1111 722793 SGTC_3301 9125354 19.7965 µM 0.818935106559657 0.228943464921257 no 793 0.20641171943998 944 41905162 SGTC_2921 7974240 10.71 µM 0.818044320124244 0.229184744719969 no 794 0.206665940310542 988 2979074 YDR527W RBA50 SGTC_1333 1482-0047 286 µM 0.81648585060406 0.229607216985217 no 795 0.207111156447454 1050 3811116 SGTC_1458 k015-0034 6.33 µM 0.815232929008115 0.229947176975002 no 796 0.207469496195346 980 3598957 SGTC_253 dyclonine 31.25 µM 0.814450274030202 0.230159680612806 no 797 0.207693523961021 1073 3180 An oral anasthetic. SGTC_2755 lomerizine 42.69 µM 0.81425187578241 0.230213566433626 no 798 0.207750336325855 1046 3949 A calcium channel blocker. SGTC_270 tamoxifen 5.46 µM 0.81328963357381 0.230475015656963 no 799 0.208026009559501 1081 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_2521 angolensin 13.4 µM 0.813042243469325 0.230542260419694 no 800 0.208096919349462 989 821428 A flavenoid. SGTC_1942 st076330 65.2 µM 0.81183165082362 0.2308714777843 no 801 0.208444118958941 1075 24208414 SGTC_3000 9075062 71.4286 µM 0.810628331444248 0.231198977199322 no 802 0.208789570910213 964 17057871 SGTC_1723 st034307 2.5525 µM 0.807476112467207 0.232058123267323 no 803 0.209696115751919 1039 867466 SGTC_3331 9141060 1.957 µM 0.805984676596951 0.232465236857039 no 804 0.210125842301814 997 4906567 YPR165W RHO1 SGTC_3210 9128157 49.47 µM 0.80403780960834 0.232997265499332 no 805 0.210687569627993 913 17590849 SGTC_3064 1327-0027 10 µM 0.803160862406573 0.233237133322319 no 806 0.210940881720659 906 16000455 YPR107C YTH1 SGTC_1359 1582-0056 520 nM 0.80296431318738 0.233290913431337 no 807 0.210997680769826 1067 3661189 SGTC_2364 9055074 200 µM 0.796596247763989 0.235037072173774 no 808 0.212842778657363 1032 6470630 SGTC_2594 a-mangostin 100 µM 0.79629633829638 0.235119486657257 no 809 0.212929906698252 1050 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_1996 st072960 66.8 µM 0.794018713744062 0.235745893635368 no 810 0.213592268514947 1067 1719405 SGTC_2818 7996756 12.99 µM 0.793422043221457 0.235910145794225 no 811 0.213765986031923 1025 2241621 SGTC_3270 9137563 49.47 µM 0.793132393672429 0.235989903597573 no 812 0.213850345650433 1000 17015724 SGTC_2047 4141938 200 µM 0.792361610291604 0.236202218619561 no 813 0.214074928555897 997 3807862 SGTC_2623 humulene 100 µM 0.791495771540043 0.236440842394308 no 814 0.21432737133901 953 6187145 An anti-inflammatory. SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.789609862079433 0.236961054988947 no 815 0.214877823465745 1037 616764 SGTC_66 0109-0187 42.4 µM 0.789149842706277 0.237088042925185 no 816 0.215012216660419 946 759417 SGTC_489 paxilline 115 µM 0.788634217741977 0.23723042517175 no 817 0.21516291285185 1042 105008 A toxic potassium channel blocker. SGTC_2557 derrustone 83.84 µM 0.78727408617638 0.237606230740592 no 818 0.215560717988204 1088 629853 An antioxidant. SGTC_2011 4012611 177 µM 0.786343852241521 0.237863443209266 no 819 0.215833034047228 1087 2049887 SGTC_3045 9092950 49.47 µM 0.785392357263741 0.238126692303155 no 820 0.216111780200245 1075 44120432 SGTC_400 oxethazaine 37.5 µM 0.785071120821799 0.238215604480687 no 821 0.216205935397401 1019 4621 A local anesthetic. SGTC_1565 sinapyl alcohol 95.1 µM 0.78458086401884 0.238351333353689 no 822 0.216349676658468 1069 5280507 A phenol propionate derived from cinnamic acid. SGTC_1435 4092-0789 56.7 µM 0.784211333528097 0.238453666819461 no 823 0.216458058016532 1067 2248285 SGTC_3245 9134821 49.47 µM 0.783808894347095 0.238565140993154 no 824 0.216576127054057 1063 17014901 SGTC_2888 9058547 12.99 µM 0.783538238057719 0.238640127830144 no 825 0.216655554108593 962 16476514 SGTC_2444 5485484 36.41 µM 0.783353838412556 0.238691224168715 no 826 0.216709677853955 1093 6790631 SGTC_391 gliotoxin 8.33 µM 0.78254192791483 0.238916272221058 no 827 0.216948077362068 1082 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_189 3970-0742 2.116 µM 0.78234927668346 0.238969688957796 no 828 0.217004667366457 1077 2891807 SGTC_3321 9137793 26.8275 µM 0.780654097253432 0.239439995670704 no 829 0.217502982586849 1093 4904192 SGTC_2716 st080858 38.6235 µM 0.778475195742645 0.240045246781149 no 830 0.218144461944196 1079 5296050 SGTC_2212 7123476 200 µM 0.778141256577575 0.240138081427405 no 831 0.218242871553359 1019 1085715 SGTC_269 exalamide 29 µM 0.774761997541223 0.241078611074473 no 832 0.219240154430147 1028 3316 A derivative of salicylamide. SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.773161114620457 0.241524873758911 no 833 0.219713518009695 1040 17037758 SGTC_3068 9116768 49.47 µM 0.772394170971625 0.241738826075441 no 834 0.219940502602803 1074 41904888 SGTC_2870 9038528 12.99 µM 0.771464450080726 0.241998325816237 no 835 0.220215843084145 1038 6463316 SGTC_1415 3966-0071 78.1 µM 0.770948180888859 0.242142489894069 no 836 0.220368823542625 1070 2893185 SGTC_130 0136-0219 337.655 µM 0.770891323687317 0.242158369662573 no 837 0.220385675144565 1056 234244 SGTC_3093 9117344 49.47 µM 0.768048663944152 0.242953021424434 no 838 0.221229137030987 1029 24824913 SGTC_288 1315-0019 35.1 µM 0.767803291814153 0.24302168009339 no 839 0.221302029276963 1095 6811474 SGTC_490 phenamil 164 µM 0.767693530442892 0.243052396308682 no 840 0.221334640331019 1007 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.767098945986221 0.243218824524811 no 841 0.221511344281653 1078 4330530 SGTC_3230 9131665 49.47 µM 0.766192956967837 0.243472535395374 no 842 0.221780749229564 1036 15943720 SGTC_2665 lovastatin 100 µM 0.7660104101736 0.243523672637888 no 843 0.221835054002278 1100 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_2358 9037157 4 µM 0.763741077033969 0.244159870093709 no 844 0.222510778349436 1079 2388925 SGTC_3133 9127736 49.47 µM 0.762494986271215 0.244509586890659 no 845 0.222882317191975 1102 27243420 SGTC_2959 9079155 11 µM 0.762129314045321 0.244612264407836 no 846 0.222991414359664 1089 16189457 SGTC_2472 5377652 49.4 µM 0.761349332286164 0.244831353935602 no 847 0.223224221082043 1083 1610903 SGTC_1626 st003712 1.76 µM 0.761326570854907 0.244837748992869 no 848 0.223231016925851 1028 24207035 SGTC_3183 9108214 49.47 µM 0.761109757168278 0.244898669525803 no 849 0.223295756541856 1012 4974831 SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.757751466173895 0.245843326441078 no 850 0.224299891118607 1060 140250 A respiratory chain inhibitor. SGTC_615 k087-0205 167 µM 0.757034558039773 0.246045239251721 no 851 0.224514579390387 1089 9642773 SGTC_2762 leflunomide 42.06 µM 0.756146481982018 0.246295483772831 no 852 0.224780687920951 1090 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_2833 9001315 45.46 µM 0.755956059562029 0.246349159286868 no 853 0.224837770534076 1072 2989378 SGTC_2296 7971656 126.45 µM 0.752067657354906 0.24744657655488 no 854 0.226005186328432 1114 666570 SGTC_1496 4469-0713 57.4 µM 0.751504821522714 0.247605640938405 no 855 0.226174450083141 1087 746691 SGTC_2282 7944268 200 µM 0.749087423659518 0.248289448164062 no 856 0.226902257300703 1118 2970414 SGTC_618 k072-0232 33.2 µM 0.749021322426929 0.248308160293694 no 857 0.226922176969669 1090 5872756 YGL099W LSG1 SGTC_1699 st031318 29.054 µM 0.746487968346335 0.249025875769138 no 858 0.227686348493298 1152 5340658 SGTC_1210 3013-0140 750 nM 0.744792008464594 0.249506968186479 no 859 0.228198733382252 1147 905973 SGTC_996 3970-0799 1.8 µM 0.743793722221275 0.249790382472504 no 860 0.228500639338496 1256 6615648 YGL040C HEM2 SGTC_2272 7805186 180 µM 0.741787961752774 0.250360335837833 no 861 0.22910790771426 1117 2956062 YPR165W RHO1 SGTC_1071 trifluoperazine 6.31 µM 0.740907215089099 0.250610824904752 no 862 0.229374850235234 1135 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_606 k015-0008 38.6 µM 0.740839721185404 0.250630026007511 no 863 0.229395313923204 1177 1970475 SGTC_2167 5876490 200 µM 0.739649635580373 0.250968717234768 no 864 0.2297563077539 1131 686534 SGTC_2343 7990716 14.84 µM 0.736657406613575 0.251821356589381 no 865 0.230665357527536 1114 6456862 SGTC_1260 0700-1617 7.75 µM 0.733147500636633 0.252823454324138 no 866 0.231734235711689 1129 2853078 SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.732128162154039 0.253114874021965 no 867 0.232045173078855 1159 165506 SGTC_1691 st019933 84.6 µM 0.731816862502503 0.253203906997241 no 868 0.232140177700906 1131 6176082 SGTC_323 4013-0906 34.3 µM 0.731360979183109 0.253334321206575 no 869 0.232279346445464 1162 2910086 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.731189003165266 0.253383527431894 no 870 0.232331858090007 1127 6708760 SGTC_2160 5660466 132.927 µM 0.730123254295122 0.253688574260647 no 871 0.232657424104635 1100 2859134 SGTC_889 0919-1524 82.7 µM 0.729074741770153 0.253988875669878 no 872 0.232977972060126 1110 3905452 SGTC_916 4466-0038 42 nM 0.727563060137708 0.254422160078713 no 873 0.23344055005734 1202 5722064 YGL116W CDC20 SGTC_1529 apigenin 74 µM 0.725933481708381 0.254889670038905 no 874 0.233939774868658 1168 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_993 3909-8757 62.7 µM 0.725898771922165 0.254899632821767 no 875 0.233950414714825 1072 4288324 YLR208W SEC13 SGTC_2625 euphol 100 µM 0.725726725088564 0.254949018596095 no 876 0.234003157454237 1149 6708538 A triterpene alcohol. SGTC_1451 4152-0210 104 µM 0.724342688260969 0.255346486274224 no 877 0.23442768780945 1150 659563 SGTC_2753 fluvastatin 17.09 µM 0.723240015163688 0.255663383574094 no 878 0.234766219287774 1137 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_2982 9019404 25.97 µM 0.722871804979776 0.255769249246822 no 879 0.234879323595099 1063 22333232 SGTC_2004 4023728 41.89 µM 0.722029334838307 0.256011557467326 no 880 0.235138221102972 1139 360084 YDR527W RBA50 SGTC_1505 k297-0037 20.6 µM 0.72025840487923 0.256521296125517 no 881 0.235682954912119 1163 4089396 SGTC_105 0111-0055 734.78 µM 0.719675289682138 0.256689253715029 no 882 0.235862471944232 1074 5179370 SGTC_1935 st074532 41.6 µM 0.719473603994097 0.256747359577602 no 883 0.235924580158776 1228 2829742 SGTC_1915 st067105 30.6 µM 0.719423473868209 0.256761803182929 no 884 0.23594001890764 1179 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_1290 0986-0249 10.2 µM 0.718032416700765 0.257162766373095 no 885 0.236368649641197 1134 53329 SGTC_3108 9121785 49.47 µM 0.717018850532866 0.257455125135674 no 886 0.236681232686509 1137 17140271 SGTC_2395 5646831 180.19 µM 0.714879685888419 0.258072724205088 no 887 0.237341695205069 1160 6808628 SGTC_2757 clomiphene 4.22 µM 0.714363251149616 0.258221939330898 no 888 0.237501294851161 1216 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_2176 5809774 33.9695 µM 0.714316878165268 0.258235340212079 no 889 0.237515628898764 1169 2870539 SGTC_2378 9074213 121.43 µM 0.713288992111293 0.258532471607735 no 890 0.2378334738622 1177 657714 SGTC_2768 sulfasalazine 50.2 µM 0.713281858789813 0.258534534258047 no 891 0.237835680456728 1194 5384001 An antioxidant and salicylic acid derivative. SGTC_1660 st012960 28.1 µM 0.712829184195325 0.258665445744742 no 892 0.237975732054066 1151 24207266 SGTC_2580 diallyl disulphide 81.36 µM 0.712226844298692 0.258839692970519 no 893 0.238162158220848 1153 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_2371 9071574 200 µM 0.711605102714721 0.259019616473108 no 894 0.238354673173869 1154 45596039 SGTC_1841 st054148 70 µM 0.711567021841968 0.259030638658084 no 895 0.238366467236446 1124 675442 SGTC_1719 st032227 49.2 µM 0.709357867598509 0.259670474517881 no 896 0.239051213224688 1207 3125804 SGTC_1340 1486-1359 257 µM 0.708081341653574 0.260040565417443 no 897 0.239447372862395 1148 4309068 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.705905391809764 0.260672043984466 no 898 0.240123487142938 1207 4213774 SGTC_2295 7971645 200 µM 0.703341694257131 0.261417061547862 no 899 0.240921416454959 1175 2978226 YKL099C UTP11 SGTC_2616 abietic acid 100 µM 0.702215524655818 0.261744674861661 no 900 0.241272382672773 1198 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_2808 7946468 45.46 µM 0.70043487003238 0.262263113512233 no 901 0.241827883014973 1178 2970879 SGTC_1507 4075-3230 155 µM 0.699046510175021 0.262667699953267 no 902 0.242261482507522 1118 659771 SGTC_2915 7971052 15.16 µM 0.698438695571398 0.262844925626025 no 903 0.242451441981317 1078 5741558 SGTC_3119 9125183 49.47 µM 0.694408067175523 0.264021715462606 no 904 0.243713168011056 1056 22695334 SGTC_984 1492-0255 2.91 µM 0.694237789235322 0.264071489172046 no 905 0.243766548822556 1135 1585198 SGTC_599 1935-0052 86.5 µM 0.693391204476678 0.26431902414642 no 906 0.244032040235764 1190 9557311 SGTC_2739 tacrine 100.86 µM 0.692942152590137 0.26445037145186 no 907 0.244172927479636 1208 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_386 1509-0011 3.07 µM 0.692859650009733 0.264474507000023 no 908 0.244198816920776 1239 3107280 SGTC_1893 st059353 36.1 µM 0.692645923552391 0.264537036381026 no 909 0.244265891506144 1176 3112488 SGTC_865 0488-0499 301 µM 0.6918914065756 0.264757843539236 no 910 0.244502763830647 1235 9634651 SGTC_11 0438-0307 1.3 µM 0.691839576628677 0.264773014858736 no 911 0.244519039814624 1199 4011476 SGTC_3170 9103054 49.47 µM 0.691753544551993 0.264798198575338 no 912 0.24454605746682 1163 16432970 SGTC_2369 9071472 200 µM 0.691308929290667 0.264928367864989 no 913 0.244685710786507 1227 17296037 SGTC_3151 9099821 49.47 µM 0.689876146909781 0.265348062370061 no 914 0.245136038670665 1172 17174189 SGTC_2345 9052315 157.45 µM 0.689542379947624 0.26544587873455 no 915 0.245241006620269 1201 6469265 SGTC_3 0833-0587 95.581 µM 0.689215894568786 0.26554157879992 no 916 0.245343707926241 1153 5382644 SGTC_1808 st050063 61.5 µM 0.68807556779396 0.26587597098956 no 917 0.245702597630809 1198 4011993 SGTC_894 0960-0238 55.9 µM 0.687969383846131 0.265907119484792 no 918 0.245736030748285 1197 6741907 YDL195W SEC31 SGTC_2439 5492030 7.2 µM 0.685802248772619 0.266543240713004 no 919 0.246418909030205 1181 5722370 SGTC_2086 5274770 176.623 µM 0.68361074157279 0.267187297622123 no 920 0.247110499983875 1213 689278 SGTC_3148 9097893 49.47 µM 0.682199587635439 0.26760243369073 no 921 0.24755637769965 1156 17174100 SGTC_431 k089-0097 107 µM 0.680939283426512 0.267973467159643 no 922 0.247954954973048 1192 5499420 SGTC_1116 jasmonic acid  1.58368 µM 0.679092377272717 0.268517663746886 no 923 0.248539666023563 1261 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_455 paf C-16 10 µM 0.676723918248025 0.26921634958099 no 924 0.249290568987428 1200 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_2707 st078556 66.6 µM 0.675352657508852 0.269621282374971 no 925 0.249725868088788 1199 17250899 SGTC_3202 9113761 49.47 µM 0.675281790954003 0.269642217532005 no 926 0.24974837524673 1259 4798415 SGTC_1665 st014639 11.4 µM 0.674490759476595 0.269875956628086 no 927 0.249999679274407 1294 981133 YIL048W NEO1 SGTC_2852 9023854 51.95 µM 0.674490759476595 0.269875956628086 no 928 0.249999679274407 1288 19798528 SGTC_466 geldanamycin 89.2 µM 0.674061461601675 0.270002850787286 no 929 0.250136119737423 1133 5288382 HSP90 inhibitor. SGTC_2242 6630449 61.2675 µM 0.670577098615008 0.271033880722398 no 930 0.251244987901061 1226 691249 YDR170C SEC7 SGTC_1758 st042942 75.2445 µM 0.656390923420206 0.275251767025991 no 931 0.255786314486888 1222 669317 SGTC_1357 1503-1303 39.5 µM 0.656298539317193 0.275279340553887 no 932 0.255816028601784 1263 292895 SGTC_911 3456-4043 236 µM 0.651975366288733 0.276571179685106 no 933 0.257208531918606 1333 914281 SGTC_2495 cafestol 54.53 µM 0.650956582805403 0.276876041976094 no 934 0.257537257076401 1282 16667697 An anti-infammatory. SGTC_1852 st056254 31.4 µM 0.647723631179682 0.277844563572209 no 935 0.258581858566626 1214 442583 SGTC_140 0062-0056 502.533 µM 0.647412996236161 0.27793771003038 no 936 0.25868234347107 1232 3758964 SGTC_2995 9067767 71.4286 µM 0.645896144829631 0.27839276925918 no 937 0.259173308237579 1271 11673567 SGTC_2568 diosmetin 100 µM 0.644698415767486 0.278752347339404 no 938 0.259561321583817 1277 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_2443 5493264 126.67 µM 0.643580555466886 0.279088151330258 no 939 0.259923731265413 1286 5340055 SGTC_1139 k015-0024 46.9 µM 0.643248873909752 0.279187825927607 no 940 0.260031312427616 1263 2766652 SGTC_2644 guaiazulene 100 µM 0.64162436912023 0.279676260388935 no 941 0.260558553190245 1280 3515 A coloring agent. SGTC_3146 9095609 49.47 µM 0.639858829930965 0.280207569021099 no 942 0.261132190828045 1329 17173999 SGTC_658 3253-0951 102 µM 0.639652358819568 0.280269734870948 no 943 0.261199317291982 1283 1184878 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.638574338502748 0.280594421656053 no 944 0.261549939775808 1301 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_968 1309-0633 340 µM 0.638402065343449 0.280646325126112 no 945 0.261605993423496 1262 3761976 SGTC_3137 9097352 49.47 µM 0.638012724066459 0.280763645262319 no 946 0.261732698658105 1363 44120435 SGTC_1222 0366-0074 1.18 µM 0.63688136329748 0.281104692526928 no 947 0.262101061514778 1316 286520 SGTC_421 streptovitacin 30 mM 0.636009643469088 0.281367607785377 no 948 0.262385068286832 1324 91467 include heat shock SGTC_12 0849-0099 9.267 µM 0.635749072205793 0.281446220474812 no 949 0.262469993122035 1234 6071388 SGTC_680 0417-1641 114 µM 0.635515479245331 0.28151670298986 no 950 0.262546137205913 1274 2835990 SGTC_921 1561-0023 372 µM 0.632775184806124 0.282344173239318 no 951 0.263440231980899 1290 24050882 SGTC_1862 st057513 3.81 µM 0.632162370350318 0.282529381108654 no 952 0.263640391628877 1271 5393163 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.63202088569622 0.282572149611259 no 953 0.263686614874002 1297 1609 A potent and irreversible inhibitor of serine proteases. SGTC_3232 9132874 49.47 µM 0.630615480075236 0.282997149717789 no 954 0.264145987329816 1267 3784940 SGTC_2640 pentamidine 10.38 µM 0.629676539358473 0.283281259911235 no 955 0.26445311753864 1306 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_351 caspofungin 25 nM 0.629541166410555 0.2833222331328 no 956 0.264497413404853 1342 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_3021 9087658 49.47 µM 0.627589019225244 0.283913403706374 no 957 0.26513660196633 1286 25237042 SGTC_106 0092-0003 11.579 µM 0.627346820157062 0.28398679022434 no 958 0.265215959505496 1297 1072148 SGTC_944 3370-0224 231 µM 0.626439687796306 0.284261732708526 no 959 0.265513292362523 1292 4580514 SGTC_1967 st070177 51.4 µM 0.62637801316171 0.284280430274474 no 960 0.26553351373686 1367 5729214 SGTC_1170 0310-0127 64.8 µM 0.625046057871374 0.284684375342501 no 961 0.265970414870567 1316 774975 SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.624743227113195 0.284776253720877 no 962 0.266069798648746 1295 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_725 1497-0963 19 µM 0.62439767456385 0.28488111110677 no 963 0.266183225944757 1321 3549977 SGTC_1489 4065-0444 182 µM 0.622962749349618 0.285316733872077 no 964 0.26665450053689 1274 2877968 SGTC_957 1187-1561 14.1 µM 0.622205349042891 0.285546797644563 no 965 0.266903424610186 1277 1538454 SGTC_2770 toltrazuril 17.5 µM 0.621283902667951 0.285826810155473 no 966 0.267206421589861 1295 68591 Kills coccidiodes. SGTC_1141 3253-0389 52.6 µM 0.619532994263852 0.286359242136308 no 967 0.267782646519351 1292 5402031 SGTC_2742 clothiapine 36.27 µM 0.618345342138361 0.286720661850813 no 968 0.268173859538231 1290 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_3090 9117696 49.47 µM 0.618193516055849 0.286766880309123 no 969 0.268223891828105 1328 7923821 SGTC_175 3793-3120 23.7 µM 0.617933327594468 0.286846094341552 no 970 0.268309644435134 1308 5322297 SGTC_2761 levamisole 97.89 µM 0.617328538926692 0.287030261504977 no 971 0.268509023240545 1371 26879 An alkaline phosphatase inhibitor. SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.617100699598705 0.287099656495695 no 972 0.26858415363533 1355 1273210 SGTC_2353 9059630 146.67 µM 0.616857729798771 0.287173668656703 no 973 0.268664284967848 1336 4779114 SGTC_1248 0469-0687 58.6 µM 0.615316997565768 0.287643208373624 no 974 0.269172697222799 1348 4017482 SGTC_590 k048-0076 22.4 µM 0.613562197474882 0.288178427036766 no 975 0.269752335122962 1375 6832814 SGTC_2863 9028737 58.44 µM 0.613102374648681 0.288318751859432 no 976 0.269904325083503 1333 6460917 SGTC_3162 9099653 49.47 µM 0.612604057006568 0.288470860571963 no 977 0.270069087516689 1304 25237511 SGTC_1073 triclabendazole 3.09 µM 0.611966717892163 0.288665459923351 no 978 0.270279888953787 1360 50248 An antihelmetic and likely tubulin inhibitor. SGTC_272 doxorubicin 8.13 µM 0.610938120788045 0.288979652791269 no 979 0.270620273339966 1316 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 0.609340476265905 0.289467984330571 no 980 0.271149391656759 1295 688662 SGTC_2674 ligustilide 100 µM 0.608341333444847 0.289773576377732 no 981 0.271480556262262 1297 5319022 A signalling regulator. SGTC_1587 estradiol valerate 56.1 µM 0.608296865157045 0.2897871807088 no 982 0.271495299900811 1315 13791 A steroid. SGTC_518 1021-0119 62.6 µM 0.607641200208363 0.289987805239075 no 983 0.271712734517554 1269 1097762 SGTC_2905 7799065 20.05 µM 0.607050820906231 0.290168508950366 no 984 0.271908592944094 1297 1296806 SGTC_2324 6149169 200 µM 0.606839487695122 0.290233206789148 no 985 0.271978719836025 1265 2888231 SGTC_2744 captopril 92.04 µM 0.605935915618757 0.290509903766593 no 986 0.272278654392084 1351 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_564 3555-0129 330 µM 0.605175571843509 0.290742836168602 no 987 0.27253117257029 1253 563260 SGTC_2957 9076800 11.52 µM 0.605163387693197 0.290746569511336 no 988 0.272535220001333 1286 16459615 SGTC_2791 5663188 71.43 µM 0.6051481330589 0.290751243711974 no 989 0.272540287453017 1361 54690634 SGTC_1895 st058434 18.3 µM 0.605041749181393 0.290783841969116 no 990 0.272575628516554 1340 5393175 SGTC_3300 9124615 50.48 µM 0.60126012362997 0.291943719967635 no 991 0.273833372364309 1401 24824903 SGTC_2214 7179297 48.276 µM 0.600887996474653 0.292057972964023 no 992 0.273957294330366 1372 769744 SGTC_901 1112-0062 60.1 µM 0.595925991392683 0.29358342652825 no 993 0.275612334454154 1351 1908457 SGTC_2326 6164455 177.58 µM 0.59575757848981 0.293635265844117 no 994 0.275668593478945 1351 2888790 SGTC_2415 st077333 57.7 µM 0.594207052275403 0.294112733577587 no 995 0.276186818250333 1474 2766255 SGTC_2782 7736369 71.43 µM 0.593636288868175 0.294288584284875 no 996 0.276377702029785 1380 2950836 YOL077C BRX1 SGTC_1778 st046819 58.9 µM 0.590721977064338 0.295187232156362 no 997 0.277353360070874 1372 671715 SGTC_138 0850-0259 40.9225 µM 0.59020222147004 0.295347634987708 no 998 0.277527541491663 1363 6813004 SGTC_3312 9133330 71.43 µM 0.589385030494442 0.295599911022836 no 999 0.277801508038701 1404 17617324 SGTC_847 0342-0274 5.54 µM 0.586810090669702 0.296395470970781 no 1000 0.278665629517593 1379 18097 SGTC_2257 7960413 200 µM 0.585726644501954 0.296730508376778 no 1001 0.279029612920926 1340 2974689 YIL048W NEO1 SGTC_1151 3909-8316 15.3 µM 0.584109447086294 0.297230921641771 no 1002 0.27957333964473 1356 800431 SGTC_2048 5246248 200 µM 0.582995575472171 0.297575813755922 no 1003 0.279948139375559 1358 677046 SGTC_1010 4112-3296 15.2 µM 0.581093620748401 0.298165144777838 no 1004 0.280588678912913 1409 704384 SGTC_468 gf-109203x 121 µM 0.580256592641202 0.29842467084787 no 1005 0.280870797444806 1313 2396 A protein kinase C inhibitor. SGTC_2213 7173844 200 µM 0.578806471377103 0.298874533625923 no 1006 0.28135988204089 1345 892728 SGTC_1369 1866-0067 208 µM 0.578725030010387 0.298899807847942 no 1007 0.281387362080371 1412 3531355 SGTC_1756 st041558 35.5 µM 0.578267191683881 0.299041909822503 no 1008 0.281541870518219 1471 3955792 SGTC_3199 9111318 49.47 µM 0.577971195570492 0.299133796200571 no 1009 0.281641783226456 1400 8548020 SGTC_164 4100-3994 89.624 µM 0.577934291686559 0.299145253209675 no 1010 0.281654241233857 1446 4615967 SGTC_857 0438-0306 1.35 µM 0.577419021503552 0.299305242407293 no 1011 0.281828213812003 1391 4686136 SGTC_203 k066-0004 30.888 µM 0.57333273809645 0.300575388021827 no 1012 0.283209711448247 1436 6795412 SGTC_2743 auranofin 4.32 µM 0.571590779896136 0.301117582375561 no 1013 0.283799621641764 1369 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_1444 4112-3581 28 µM 0.571586331345695 0.30111896757611 no 1014 0.283801128886081 1403 2877249 SGTC_2490 carminic acid 95.39 µM 0.571437638877075 0.301165269453644 no 1015 0.283851510620428 1348 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_700 3453-2283 142 µM 0.570637148861824 0.301414591988877 no 1016 0.284122815622095 1445 565664 SGTC_1148 3909-7663 27.7 µM 0.569019687187154 0.3019186537693 no 1017 0.284671389802078 1436 4084526 SGTC_1519 esterone 74 µM 0.567698411074627 0.30233069383408 no 1018 0.285119885331533 1331 698 A steroid. SGTC_2093 5331342 194.4 µM 0.567098073654906 0.302517992417903 no 1019 0.285323775801401 1404 33839 SGTC_326 k292-0812 17.5 µM 0.566244444770152 0.302784404642004 no 1020 0.285613810285424 1394 3579357 SGTC_3269 9137823 49.47 µM 0.565765800061303 0.302933832615227 no 1021 0.285776499081278 1336 17682936 SGTC_2136 5328288 199.296 µM 0.563207221857964 0.303733153665276 no 1022 0.286646892891175 1362 262395 SGTC_2555 cholic acid 100 µM 0.563068591221064 0.303776489894442 no 1023 0.286694089045974 1386 6708657 Influences liver metabolism. SGTC_1559 coumarin 343 70.1 µM 0.56153685708767 0.304255496730213 no 1024 0.287215805900386 1452 108770 A hepatotoxic, DNA x-linker. SGTC_557 1315-0110 16.2 µM 0.561244706528082 0.304346896801274 no 1025 0.287315364951218 1368 6833801 SGTC_2664 lyso-paf C-16 73.48 µM 0.560757067747797 0.304499483101229 no 1026 0.287481578830716 1401 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_311 1315-0136 58 µM 0.560266089165707 0.304653148835152 no 1027 0.287648977021618 1452 6759207 SGTC_935 2996-0153 430 µM 0.553574279152345 0.306750969475762 no 1028 0.289935116383018 1422 23738523 SGTC_1870 st057514 26.5 µM 0.552841053620507 0.306981215856377 no 1029 0.290186127047953 1397 5393161 SGTC_3341 9147222 25.867 µM 0.552331122393378 0.307141388594375 no 1030 0.290360755683198 1401 1939759 SGTC_1974 st069448 26.9 µM 0.55181954293707 0.307302116036977 no 1031 0.290535998193166 1421 6323587 YNR016C ACC1 SGTC_1785 bathophenanthroline 24 µM 0.550736254480532 0.307642584514516 no 1032 0.290907243976868 1383 72812 An iron chelator. SGTC_626 0214-0009 33 µM 0.546587551465375 0.308948017954444 no 1033 0.292331061673215 1506 3437874 SGTC_1150 3909-7983 10.9 µM 0.546013198874876 0.309128934919278 no 1034 0.292528432214863 1380 23965914 SGTC_1257 0669-0121 16 µM 0.545758083464093 0.309209309304639 no 1035 0.292616119940614 1479 4307855 SGTC_2183 6420625 130.508 µM 0.545614539180011 0.309254537100991 no 1036 0.292665464044263 1399 2897619 SGTC_2447 5741742 33.78 µM 0.545490037610047 0.309293767277879 no 1037 0.292708265244393 1500 1776504 SGTC_251 melphalan 456.522 µM 0.545192759000766 0.309387447920735 no 1038 0.292810475561345 1502 460612 A DNA alkylator. SGTC_1106 tegaserod maleate 11.7 µM 0.545114972099976 0.309411962751941 no 1039 0.29283722298468 1458 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_94 0334-0113 514.748 µM 0.542692409472497 0.310175866502458 no 1040 0.293670800650355 1363 6795178 SGTC_2917 7979103 53.79 µM 0.542408649177753 0.31026539799729 no 1041 0.293768511321353 1497 2980565 SGTC_699 0375-0592 111 µM 0.541759534702255 0.310470247612642 no 1042 0.293992085434536 1445 762578 SGTC_950 1165-0508 94.1 µM 0.537492011837788 0.311818467666352 no 1043 0.295463900643202 1399 6148369 SGTC_1648 st011736 69.8 µM 0.5371087847202 0.311939662805739 no 1044 0.295596236546629 1483 2855514 SGTC_495 decylubiquinone 155 µM 0.536853674598344 0.312020352381922 no 1045 0.295684346221753 1379 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_3171 9103192 49.47 µM 0.533554304865828 0.313064731961267 no 1046 0.296824965051132 1465 13018434 SGTC_2356 9061756 188.97 µM 0.533226273009309 0.31316864907729 no 1047 0.296938478303451 1450 20104043 SGTC_1645 Cervolide 78 µM 0.532587113283078 0.313371170921866 no 1048 0.297159712326429 1397 23173 A fragrance. SGTC_3032 9089427 49.47 µM 0.531910655235528 0.313585572289804 no 1049 0.297393938557429 1415 17173707 SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.528169933171246 0.31477231868019 no 1050 0.298690697913091 1419 16486 A toxic proline analog. SGTC_2327 6189656 200 µM 0.527615939519187 0.314948236650866 no 1051 0.29888296379386 1554 5349088 SGTC_632 0781-2353 4.65 µM 0.527552655662642 0.314968334802564 no 1052 0.29890493030641 1469 6811515 YHR007C ERG11 SGTC_1931 st074438 57.1 µM 0.527369030168113 0.315026655036261 no 1053 0.298968672856954 1411 2787313 SGTC_2711 st079103 59.1 µM 0.526926135621003 0.315167339191562 no 1054 0.29912244176417 1501 54693780 SGTC_1100 amiodarone 5.07 µM 0.523683781847041 0.316198078915108 no 1055 0.300249248843058 1480 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_1494 4358-1428 177 µM 0.522032883143218 0.316723447260459 no 1056 0.300823717795999 1553 1564571 SGTC_247 mechlorethamine 29.705 µM 0.521830408898291 0.316787906473879 no 1057 0.300894207583198 1423 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_501 nsc-95397 161 µM 0.519140765505337 0.317644701988441 no 1058 0.301831291202636 1519 262093 SGTC_2492 derrusnin 100 µM 0.517887656340007 0.318044218517005 no 1059 0.302268327389774 1392 1715307 Part of coumarin class of compounds. SGTC_2330 7979373 200 µM 0.517643157653151 0.31812219435209 no 1060 0.302353632204267 1361 1863007 SGTC_1429 4049-0205 9.46 µM 0.517373976262714 0.318208051350606 no 1061 0.302447561222552 1461 22774478 SGTC_720 r052-1644 49.9 µM 0.51733569498819 0.318220262183264 no 1062 0.302460920275983 1446 1422863 YOR257W CDC31 SGTC_1992 st073643 23.3 µM 0.517197826718247 0.318264240578778 no 1063 0.30250903449172 1462 3161292 SGTC_1030 k029-0042 36.7 µM 0.515086802100496 0.318937952811749 no 1064 0.303246182425015 1496 6080581 SGTC_2045 5106652 78.05 µM 0.512599696010701 0.319732455769669 no 1065 0.304115682948147 1500 673349 SGTC_1574 spiramycin 23.7 µM 0.509704951976656 0.320658220674471 no 1066 0.305129091598771 1406 6419898 An antibiotic and protein synthesis inhibitor. SGTC_1292 0kpi-0043 232 µM 0.507705938432087 0.321298175223936 no 1067 0.305829791600987 1449 3333905 SGTC_2689 tacrolimus 100 µM 0.507491888179612 0.321366731740785 no 1068 0.305904863322926 1478 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_722 3534-0461 190 µM 0.50722502296607 0.321452212481284 no 1069 0.305998469734055 1440 658262 SGTC_1704 st028805 70.8 µM 0.505724306531342 0.321933089402277 no 1070 0.306525101201012 1456 2876101 SGTC_1079 idarubicin 2.36 µM 0.503936917956785 0.32250621438185 no 1071 0.30715285329315 1465 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2657 nystatin 74.44 µM 0.503485412284965 0.322651056206178 no 1072 0.307311517002442 1512 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2499 avocadenofuran 51.48 µM 0.503321603950636 0.322703612141179 no 1073 0.307369089844889 1410 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.499653371056323 0.323881446652109 no 1074 0.308659585331781 1542 5377381 SGTC_1231 0242-0792 125 µM 0.499151819722292 0.32404262746547 no 1075 0.30883621688556 1449 3707635 SGTC_2600 tangeritin 87.95 µM 0.496232969023133 0.324981296451142 no 1076 0.309865026358949 1412 68077 A bioactive flavone. SGTC_1421 4029-0249 71.4 µM 0.49606703953264 0.325034690938127 no 1077 0.309923556508277 1581 2894095 SGTC_2438 5259590 200 µM 0.496014124166642 0.325051719341108 no 1078 0.309942222945428 1565 1201127 SGTC_2193 5925765 200 µM 0.488735980250044 0.327397327536574 no 1079 0.312514313649987 1541 877370 SGTC_2252 omeprazole 400 µM 0.488239594324022 0.327557553188027 no 1080 0.312690071114241 1556 4594 A proton pump inhibitor. SGTC_414 piperonyl butoxide 100 µM 0.486864165440715 0.328001686098306 no 1081 0.313177297496407 1458 5794 A potent inhibitor of cytochrome P450. SGTC_2143 5623677 140.463 µM 0.484633317450084 0.328722555333718 no 1082 0.313968237760534 1492 5375313 SGTC_1943 st076331 65.2 µM 0.482703405662231 0.329346695665557 no 1083 0.314653172375433 1532 24208415 SGTC_318 1488-0629 67.2 µM 0.481796205474963 0.329640251949256 no 1084 0.314975362603786 1470 3662576 SGTC_3267 9137951 49.47 µM 0.48172777500137 0.329662399278088 no 1085 0.31499967125745 1535 16643986 SGTC_2277 7947813 106.88 µM 0.48101207990262 0.329894067750286 no 1086 0.31525395663841 1611 1246798 SGTC_674 0498-0004 451 µM 0.479408714142965 0.330413309467277 no 1087 0.315823947694834 1465 4231473 SGTC_580 1123-0028 41 µM 0.478613446137199 0.330670974163069 no 1088 0.316106825440744 1534 1677248 YPR107C YTH1 SGTC_1614 st002383 48.6 µM 0.476830978815593 0.33124878019469 no 1089 0.316741242098643 1512 1947235 SGTC_1860 st056228 74.6 µM 0.475812511895849 0.331579107811291 no 1090 0.317103977623328 1480 688679 SGTC_307 1501-1223 22.3 µM 0.475649028628772 0.331632143872925 no 1091 0.31716221994262 1510 2830329 SGTC_3342 9147791 14.508 µM 0.474792273105421 0.331910141491451 no 1092 0.317467520497494 1485 1838168 SGTC_701 4424-0219 185 µM 0.473491268685672 0.332332464712298 no 1093 0.317931364399888 1618 2911779 SGTC_1969 st069479 40.1 µM 0.472228397944004 0.332742612965333 no 1094 0.318381885980247 1603 3895485 SGTC_2292 7671323 168.05 µM 0.471940422491351 0.332836168113995 no 1095 0.318484657149771 1509 937504 SGTC_2175 5807670 165.306 µM 0.471566909723235 0.332957527442297 no 1096 0.318617975234927 1504 241186 SGTC_2926 9010726 65.15 µM 0.471200917299698 0.333076460283862 no 1097 0.318748631859834 1467 2994293 SGTC_1631 benzylvanillin 81.9 µM 0.466451610689685 0.334621313171707 no 1098 0.320446138226716 1553 75506 SGTC_458 nppb 133 µM 0.465966788615847 0.334779174093545 no 1099 0.320619636546617 1645 4549 A chloride channel blocker. SGTC_1334 1486-0610 236 µM 0.465426832039748 0.334955021507508 no 1100 0.320812911425664 1554 3742339 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.464658597752797 0.335205274387384 no 1101 0.321087980936374 1495 2333 A French combination drug. SGTC_2132 5317594 122.667 µM 0.463876752421685 0.335460036193053 no 1102 0.321368024771358 1572 794577 SGTC_2829 7992743 58.44 µM 0.458256043761527 0.337293747543034 no 1103 0.323384250012297 1686 16462845 SGTC_2910 7948405 25.97 µM 0.457420849016906 0.337566554600035 no 1104 0.323684290776793 1628 2971328 SGTC_2096 5468907 200 µM 0.457361529886091 0.337585933782411 no 1105 0.323705605327713 1655 759785 SGTC_55 0767-0285 6.563 µM 0.456711054235252 0.337798468283369 no 1106 0.323939372173361 1510 3116166 SGTC_350 k064-0020 19.8 µM 0.454910227902531 0.338387134656541 no 1107 0.324586912195402 1633 2790705 SGTC_2874 9043904 71.43 µM 0.454607431960689 0.338486153505035 no 1108 0.324695843536593 1536 4463428 SGTC_2931 9014674 55.67 µM 0.453851475490151 0.338733411427112 no 1109 0.324967865563815 1482 2996810 SGTC_45 0kpi-0036 14.9 µM 0.453837163809811 0.338738093156247 no 1110 0.324973016354038 1588 2795021 SGTC_452 diindolylmethane 8 µM 0.453076196853194 0.338987061439065 no 1111 0.325246937397709 1581 3071 Inhibits expression of several cancer promoting factors. SGTC_3117 9124945 49.47 µM 0.4527048186392 0.339108592126872 no 1112 0.325380654654167 1441 17592065 SGTC_15 0266-0086 27.098 µM 0.452477136970591 0.339183107495957 no 1113 0.325462644108356 1603 1712902 YIL048W NEO1 SGTC_1793 st048256 72.231 µM 0.451061593216771 0.33964652590014 no 1114 0.32597257878643 1509 672022 SGTC_427 1354-0053 47.3 µM 0.450086778335494 0.339965800264659 no 1115 0.32632393496911 1631 6813657 SGTC_836 0330-0104 1.35 µM 0.449546023745385 0.340142959394989 no 1116 0.326518907681627 1577 46494820 SGTC_1683 st010134 710 nM 0.449545024233813 0.340143286882324 no 1117 0.326519268106165 1515 3818134 SGTC_1066 ketoconazole 628 nM 0.448586064410096 0.340457543073019 no 1118 0.326865144229092 1630 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_322 k048-0136 19.3 µM 0.44833269505921 0.340540592060418 no 1119 0.326956553953438 1546 6823282 SGTC_1611 st001856 99.4 µM 0.448199119457733 0.340584378363454 no 1120 0.327004749080862 1513 647478 SGTC_801 0866-0028 10.1 µM 0.446917883390812 0.34100447873118 no 1121 0.327467175603439 1567 6849771 SGTC_2638 epoxomicin 18 µM 0.44662824199583 0.341099475662968 no 1122 0.327571750336843 1658 9915668 A protesome inhibitor. SGTC_1627 st003713 25.6 µM 0.446525206879822 0.341133271673163 no 1123 0.327608954324227 1555 16195070 YER133W GLC7 SGTC_1825 st052143 62.6 µM 0.446294856930888 0.341208832166095 no 1124 0.327692135425713 1615 674173 SGTC_1282 0886-0010 32.4 µM 0.445318931675332 0.341529030444329 no 1125 0.328044644210228 1673 2836211 YNL267W PIK1 SGTC_2685 mycophenolic acid 18.85 µM 0.442853389472329 0.342338475526411 no 1126 0.328935891586092 1609 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_1105 epirubicin 18.1 µM 0.442391819096513 0.34249009115591 no 1127 0.329102848972844 1508 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_621 3584-0052 32.1 µM 0.442384197125172 0.342492595017527 no 1128 0.329105606248013 1641 2273927 SGTC_209 4077-0173 175.592 µM 0.441631311160622 0.342739956501133 no 1129 0.329378011211454 1568 15993494 SGTC_3104 9120930 49.47 µM 0.441021324792425 0.34294041763189 no 1130 0.329598779482597 1563 17014836 SGTC_2159 5658611 73.75 µM 0.440872019093455 0.342989491023164 no 1131 0.329652825743185 1602 793844 SGTC_1754 st042065 16.137 µM 0.440114101859937 0.34323864203266 no 1132 0.329927234434273 1510 1126236 YIL048W NEO1 SGTC_170 4197-0004 226 µM 0.439778585396215 0.343348958517902 no 1133 0.330048739517332 1619 218692 SGTC_1450 4112-4260 37.6 µM 0.438837033808473 0.343658608215256 no 1134 0.330389811961491 1653 1633175 SGTC_1963 st076565 50.3 µM 0.438301283868803 0.343834848077227 no 1135 0.330583947686003 1557 4914280 SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.433844249661894 0.345302342899326 no 1136 0.332200773149546 1668 94937 An inhibitor of serotonin biosynthesis. SGTC_1061 3448-9325 110 µM 0.433757425960374 0.345330953115621 no 1137 0.332232300313642 1576 723482 SGTC_1384 3089-0840 101 µM 0.433243555380373 0.345500302255131 no 1138 0.332418919772485 1678 1069836 SGTC_2083 5306046 65.942 µM 0.432450452709433 0.345761734705471 no 1139 0.332707027903864 1560 539837 SGTC_487 nimodipine 119 µM 0.429596494918793 0.346703099942306 no 1140 0.333744593610048 1645 4497 L-type voltage-gated calcium channels inhibitor SGTC_2368 9071271 200 µM 0.429552915973763 0.346717481619927 no 1141 0.333760446762517 1535 27209959 SGTC_586 0957-0265 8.15 µM 0.42426024630123 0.348465775577738 no 1142 0.335688013944643 1591 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_1389 3405-0187 19 µM 0.424203008333765 0.34848470031889 no 1143 0.335708883526284 1547 799890 SGTC_1706 st031321 9.9705 µM 0.42377811435 0.348625195932963 no 1144 0.335863820304373 1665 6103185 SGTC_1236 0330-0013 258 µM 0.423703194274705 0.348649971188938 no 1145 0.335891142660645 1585 4617066 SGTC_1190 1486-1332 13 µM 0.423630594465158 0.348673979774042 no 1146 0.335917619674276 1546 4150046 SGTC_2618 avocadyne 43.43 µM 0.422173958319298 0.349155813851416 no 1147 0.33644902405297 1658 3015189 SGTC_930 2810-3379 265 µM 0.421871052843089 0.349256041161127 no 1148 0.336559569946764 1734 1015764 SGTC_3131 9127911 49.47 µM 0.421423473517425 0.349404158327344 no 1149 0.336722940677303 1636 45595681 SGTC_2978 9011784 42.97 µM 0.421143352580487 0.349496870256666 no 1150 0.336825203177075 1780 2994934 SGTC_2320 7373003 200 µM 0.418247715646999 0.350455767569274 no 1151 0.337883006167519 1524 5415828 SGTC_1143 3454-2408 5.08 µM 0.418160801332163 0.350484564233118 no 1152 0.337914776623858 1587 X1143 SGTC_1090 efavirenz 20.7 µM 0.417608368522595 0.350667617708559 no 1153 0.338116738613074 1646 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_3213 9129884 49.47 µM 0.417315489880842 0.350764679693593 no 1154 0.338223830001131 1468 17190742 SGTC_520 3584-0023 682 µM 0.416627596915163 0.350992690426265 no 1155 0.338475410262468 1572 1340790 SGTC_726 3448-4391 34.2 µM 0.41419302891135 0.351800089017785 no 1156 0.339366373357615 1722 1356692 SGTC_3330 9141424 71.43 µM 0.413104242447355 0.352161390137134 no 1157 0.339765120643761 1704 27261020 SGTC_313 3474-0040 5.03 µM 0.409957557185689 0.353206330406384 no 1158 0.340918541153757 1581 1043375 YIL048W NEO1 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.408867938239351 0.353568425876879 no 1159 0.341318289554159 1627 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_1947 st076332 61.6 µM 0.406170113701701 0.354465520109805 no 1160 0.342308805867748 1646 24208416 SGTC_1004 4084-0029 199 µM 0.405945416985437 0.354540273913447 no 1161 0.342391353177115 1738 716894 YLR208W SEC13 SGTC_213 1246-0773 967 nM 0.404294615022541 0.355089646830262 no 1162 0.3429980424448 1643 6251622 SGTC_696 1560-0013 611 µM 0.402884291979112 0.355559229177506 no 1163 0.343516673751953 1678 1650269 SGTC_1620 st003704 16.5 µM 0.400988682650853 0.356190738274434 no 1164 0.344214228137266 1664 2834414 SGTC_1853 st056710 91.2 µM 0.400404582347714 0.356385406857271 no 1165 0.344429274851331 1763 269167 SGTC_2927 9011802 47.9 µM 0.39979993837852 0.356586961646098 no 1166 0.344651938058652 1544 43912568 SGTC_1216 1165-0504 9.65 µM 0.394598076481371 0.358322623470679 no 1167 0.346569766661616 1727 6304004 SGTC_2208 7283366 200 µM 0.393607374964687 0.358653515975963 no 1168 0.34693546773048 1731 898663 SGTC_3176 9106582 49.47 µM 0.393416435192172 0.358717301718553 no 1169 0.347005966390791 1641 17018027 SGTC_2911 7942208 15.64 µM 0.392603497958996 0.358988917328898 no 1170 0.34730617780161 1610 1243384 SGTC_1615 st002656 86.5 µM 0.392442737214459 0.35904263856893 no 1171 0.347365556851452 1615 1584458 SGTC_1454 4239-0054 42.6 µM 0.390246644719206 0.359776783103539 no 1172 0.348177086469886 1731 1340767 SGTC_3240 9133527 49.47 µM 0.389679209038537 0.359966558748557 no 1173 0.348386886180822 1623 17617455 SGTC_1591 genipin 88.4 µM 0.389289786603543 0.360096818852245 no 1174 0.34853089536549 1701 442424 A DNA cross-linking agent. SGTC_3336 9143619 71.43 µM 0.388177714878221 0.360468891381865 no 1175 0.348942261819356 1703 45595730 SGTC_902 1120-0002 2.07 µM 0.384645663608509 0.361651506002317 no 1176 0.350249978763714 1592 3280475 SGTC_194 1486-1323 56.904 µM 0.384239023402502 0.361787743915219 no 1177 0.350400648804111 1607 5178754 SGTC_1035 k081-0041 55.2 µM 0.383263916471214 0.36211450832103 no 1178 0.350762045406105 1762 731709 SGTC_2798 7813637 45.45 µM 0.383242866621626 0.362121563365943 no 1179 0.350769848445316 1713 956368 SGTC_1735 st034310 56.75 µM 0.383067306506632 0.36218040572926 no 1180 0.35083492986362 1739 871153 SGTC_2544 sphondin 68.51 µM 0.38275726960757 0.362284328538111 no 1181 0.350949873498052 1727 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_3181 9108277 49.47 µM 0.381735400740755 0.362626925667778 no 1182 0.351328819511967 1618 17097298 SGTC_1753 st043925 64 µM 0.381355254669004 0.362754403529672 no 1183 0.351469829203361 1748 670181 SGTC_2881 9058953 51.95 µM 0.380584523543606 0.363012906528756 no 1184 0.35175578349977 1569 17122249 SGTC_2374 9071832 200 µM 0.380448164480655 0.363058647821964 no 1185 0.351806383758902 1644 17381698 SGTC_1482 3346-2049 8.48 µM 0.378095127651625 0.363848275101617 no 1186 0.352679963853356 1715 3826804 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.37518032656106 0.364827220067762 no 1187 0.353763180244522 1658 4000243 SGTC_3019 9081971 49.47 µM 0.375048316396695 0.364871577012233 no 1188 0.35381226679182 1765 16451803 SGTC_1783 st039459 87.517 µM 0.374479942193246 0.365062577979553 no 1189 0.354023638321577 1794 729761 SGTC_2505 galangin 7.89 µM 0.373765715695681 0.365302639777182 no 1190 0.354289314352718 1627 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_741 4582-0002 126 µM 0.372364249755168 0.365773845971208 no 1191 0.354810833882936 1628 2912688 SGTC_496 calpeptin 138 µM 0.372178483845605 0.365836320111179 no 1192 0.354879982344539 1620 73364 A calpain inhibitor. SGTC_2504 purpurogallin 52.29 µM 0.370700141776592 0.366333621722183 no 1193 0.355430442360854 1645 5281571 An antioxidant. SGTC_1284 0929-0043 16 µM 0.368132947389055 0.367197737071206 no 1194 0.356387052415049 1655 1239883 SGTC_1734 st037168 69.4 µM 0.364296561007378 0.368490314750096 no 1195 0.357818283811035 1657 708907 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 0.362675595248618 0.369036908514764 no 1196 0.358423616196885 1630 688669 SGTC_1680 diphenhydramine 100 µM 0.36099828737414 0.369602779909196 no 1197 0.359050363673129 1677 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_2237 6667747 47.222 µM 0.360294092509891 0.369840437591988 no 1198 0.359313608296122 1647 729940 YDL015C TSC13 SGTC_2832 7992762 51.95 µM 0.358832145618171 0.370333986556556 no 1199 0.359860331629193 1504 2985177 SGTC_552 k242-0005 476 µM 0.358278046829601 0.370521104525412 no 1200 0.360067622621636 1685 4088318 SGTC_2253 7938677 135.83 µM 0.357741733932436 0.370702245414934 no 1201 0.360268299023484 1816 2301972 SGTC_1045 1348-1485 165 µM 0.356682081739569 0.371060229563687 no 1202 0.360664910544751 1677 6810614 SGTC_2794 7785382 27.27 µM 0.356247680672294 0.371207016307116 no 1203 0.360827543536802 1852 2205081 SGTC_1995 st072814 61.1 µM 0.355406301390152 0.371491376722612 no 1204 0.361142614396527 1657 5769371 SGTC_1055 3448-0672 86 µM 0.355243324392483 0.371546466068517 no 1205 0.36120365520774 1703 748378 SGTC_2679 rapamycin 1 nM 0.354880677927218 0.371669056956943 no 1206 0.361339492173368 1721 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_3139 9095020 49.47 µM 0.353235826879866 0.372225254146876 no 1207 0.361955825452962 1632 25236292 SGTC_2476 5806916 10.51 µM 0.352478599728588 0.372481395987429 no 1208 0.362239682460151 1738 2870194 SGTC_3295 9122362 53.5725 µM 0.350917008911129 0.373009802217339 no 1209 0.362825305344532 1681 4730473 SGTC_72 0744-0168 198.391 µM 0.349513126118237 0.373485047739908 no 1210 0.36335205910847 1741 677577 SGTC_943 3253-1379 105 µM 0.349342957216106 0.373542666788736 no 1211 0.363415926119792 1782 668464 SGTC_2772 vinpocetine 57.06 µM 0.348997872827123 0.373659520754208 no 1212 0.363545453263869 1768 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_1744 st037937 38.9 µM 0.348149526388386 0.373946840845946 no 1213 0.363863945697042 1751 1016152 SGTC_3166 9102297 49.47 µM 0.347621927315828 0.374125564758979 no 1214 0.36406206826715 1662 25237072 SGTC_1690 st023502 41.2 µM 0.345619333822215 0.374804188246831 no 1215 0.364814407067825 1815 24207482 SGTC_227 fluconazole 33.516 µM 0.345506006932491 0.374842603207069 no 1216 0.364856997565056 1667 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.345435922382229 0.374866360725263 no 1217 0.36488333756639 1780 804 An inhibitor of viral and cellular DNA polymerases. SGTC_2074 5212007 75.395 µM 0.345282042108581 0.374918525291307 no 1218 0.364941172900682 1855 758611 SGTC_330 1488-0319 80.1 µM 0.344344105507062 0.375236530088739 no 1219 0.365293759323842 1729 6846614 SGTC_3020 9089140 49.47 µM 0.343627382066356 0.375479590359301 no 1220 0.36556326471673 1704 17217859 SGTC_774 k060-0086 136 µM 0.343534408659134 0.375511123776341 no 1221 0.365598229839034 1883 5911235 SGTC_447 ml7 120 µM 0.339817576360728 0.376772425995504 no 1222 0.366996955373211 1790 4216 Selective myosin light chain kinase inhibitor. SGTC_1207 2099-0101 141 µM 0.339532701378991 0.376869152435265 no 1223 0.367104233232815 1840 5837381 SGTC_2291 7917025 104.35 µM 0.339326632933145 0.376939125724871 no 1224 0.367181840695465 1659 2964612 SGTC_2204 7233102 200 µM 0.338950468214613 0.377066867895124 no 1225 0.367323522129065 1773 2172480 SGTC_1314 1222-0010 41.1 µM 0.337569018210707 0.377536111296224 no 1226 0.367843996435412 1739 3526027 SGTC_1508 1080-0625 72.9 µM 0.337144872345143 0.377680219164188 no 1227 0.368003846139531 1734 767111 SGTC_1171 0368-0077 21.4 µM 0.336916798304282 0.377757716678477 no 1228 0.368089810851813 1705 3239779 SGTC_2510 benzyl isothiocyanate 8.31 µM 0.333636469691719 0.378872885840754 no 1229 0.36932694738569 1721 2346 DNA damaging agent; causes G2/M arrest. SGTC_161 4065-0411 162.148 µM 0.333179692404301 0.379028250516219 no 1230 0.369499323175987 1754 1906281 YLR208W SEC13 SGTC_1411 3909-8223 150 µM 0.332891169657008 0.379126396474125 no 1231 0.369608217629222 1830 X1411 SGTC_922 1866-0035 480 µM 0.331814029847814 0.379492872844486 no 1232 0.370014844823376 1746 3156169 SGTC_362 0310-0100 9.03 µM 0.331516162869415 0.379594235557091 no 1233 0.370127317194455 1710 790235 SGTC_1142 3253-1408 9.78 µM 0.330756375828504 0.379852824924681 no 1234 0.370414257447237 1841 256655 SGTC_89 0302-0250 142.109 µM 0.330122738295211 0.38006852109356 no 1235 0.370653611387573 1776 4203518 YLR208W SEC13 SGTC_1147 3809-1045 12.3 µM 0.329267440140168 0.380359731778535 no 1236 0.370976776100762 1723 325925 SGTC_2019 4016004 108 µM 0.329204284004623 0.380381237779572 no 1237 0.371000642542063 1688 45595336 SGTC_3288 9119690 36.221 µM 0.328445757476225 0.380639560989252 no 1238 0.371287325311448 1680 17595618 YKL019W RAM2 SGTC_3126 9127922 49.47 µM 0.326363481918269 0.38134897244369 no 1239 0.372074681712295 1768 45595682 SGTC_537 1334-0398 209 µM 0.326224940942671 0.38139618621199 no 1240 0.372127086274076 1874 5846986 SGTC_1761 st044296 37 µM 0.324264487753796 0.382064483463999 no 1241 0.372868901511358 1692 1826700 SGTC_1741 st038134 10.228 µM 0.324262286066249 0.382065234193421 no 1242 0.372869734872845 1856 1272587 SGTC_1428 4049-0204 61.7 µM 0.323360446364804 0.382372779936612 no 1243 0.373211140511229 1830 X1428 SGTC_1328 1441-0025 69.2 µM 0.323017987004065 0.382489585019759 no 1244 0.373340810000571 1651 4562601 SGTC_717 1532-0246 73.2 µM 0.321209701004526 0.383106527208476 no 1245 0.374025740515094 1732 9561992 SGTC_3195 9113082 49.47 µM 0.320633238814398 0.383303264189864 no 1246 0.374244172768151 1892 17018038 SGTC_3322 9139058 2.11 µM 0.317644528522632 0.384323742907605 no 1247 0.375377296601327 1813 4908926 YPR165W RHO1 SGTC_1430 4049-0248 69.1 µM 0.315721023340067 0.384980937994602 no 1248 0.376107133990184 1859 22774488 SGTC_2564 betulinic acid 100 µM 0.314915010224222 0.385256423142769 no 1249 0.376413092263731 1968 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_2463 5473429 200 µM 0.314454478939532 0.385413852952916 no 1250 0.376587942358295 1737 5399405 SGTC_2958 9077254 16.72 µM 0.312474620838156 0.386090870147962 no 1251 0.377339923888423 1753 16457351 SGTC_148 3253-0744 288.01 µM 0.312056143678737 0.386234013905458 no 1252 0.377498927821288 1702 6893655 SGTC_341 1486-1430 230 µM 0.311370268247255 0.386468657054258 no 1253 0.377759576883204 1706 2054753 YPL210C SRP72 SGTC_271 rotenone 740 µM 0.311108139349321 0.386558344294498 no 1254 0.377859206841239 1840 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_1177 0983-0204 23.6 µM 0.310463367941099 0.386778978209305 no 1255 0.378104306134469 1906 766818 SGTC_960 1222-0186 7.7 µM 0.310442271548985 0.386786197788885 no 1256 0.378112326412 1823 3126296 SGTC_2187 6125751 200 µM 0.30976488429224 0.387018033177522 no 1257 0.378369878623638 1786 874498 SGTC_982 1491-0518 27.5 µM 0.308426918580148 0.387476069531469 no 1258 0.378878750808798 1769 3091256 SGTC_329 k048-0121 21.3 µM 0.30831235274762 0.387515297047252 no 1259 0.378922333721566 1746 6832902 SGTC_1457 k015-0032 57.3 µM 0.306857547942769 0.388013524182118 no 1260 0.379475901474017 1750 4302660 SGTC_2040 5100729 123 µM 0.306798906559114 0.388033610973653 no 1261 0.37949822029559 1809 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_259 usnic acid 108.925 µM 0.306173610747539 0.388247815986804 no 1262 0.379736231886776 1854 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2027 5150920 200 µM 0.305758268236661 0.388390116957434 no 1263 0.37989435238502 1838 786715 SGTC_34 0469-0683 81.75 µM 0.305259308308803 0.388561085995561 no 1264 0.380084332505031 1836 3690923 SGTC_3058 9093861 49.47 µM 0.303258580880392 0.389246853477003 no 1265 0.380846404223805 1812 17217477 SGTC_2493 resveratrol 26.09 µM 0.303171272195912 0.389276787194699 no 1266 0.380879670420168 1729 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_250 brefeldin a 552.239 µM 0.302102454141401 0.389643283877876 no 1267 0.381286980834305 1776 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_1471 k673-0312 37 µM 0.301927748974197 0.389703199453883 no 1268 0.381353570853151 1883 24099884 SGTC_672 1441-0018 53.7 µM 0.301289090910245 0.389922251138079 no 1269 0.381597029434719 1735 251141 SGTC_3254 9136651 49.47 µM 0.301223941917793 0.389944598389585 no 1270 0.381621867082572 1752 16454030 SGTC_907 3448-6986 75.5 µM 0.300704446443458 0.390122807493767 no 1271 0.381819938930343 1872 590582 SGTC_2722 naftopidil 47.16 µM 0.300522819681546 0.39018511866998 no 1272 0.381889196400394 1861 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_3001 9076041 71.4286 µM 0.298837304681935 0.390763507168034 no 1273 0.382532092884969 1773 16004211 SGTC_3129 9127257 49.47 µM 0.29864520037126 0.390829443592038 no 1274 0.382605386742524 1662 837894 SGTC_579 4491-1009 110 µM 0.297579490462188 0.391195286720585 no 1275 0.38301206501023 1957 1271041 SGTC_2094 5332512 191.667 µM 0.296551116499682 0.39154840424168 no 1276 0.3834046180597 1877 755774 SGTC_817 1391-0715 46 µM 0.296470340599505 0.391576144425818 no 1277 0.383435457081091 1729 1353946 SGTC_1976 st070609 63.5 µM 0.295761705300747 0.391819528673076 no 1278 0.383706034997899 1791 682556 SGTC_687 k029-0044 34.9 µM 0.295533781423912 0.391897819243774 no 1279 0.383793075136059 1925 5829338 SGTC_2506 ethyl hematommate 54.16 µM 0.295195979151037 0.392013860476743 no 1280 0.383922086692997 1713 3940691 An allergen. SGTC_1873 rapamycin 2 nM 0.294816953857024 0.392144074003339 no 1281 0.384066857231427 1755 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_2063 5246145 200 µM 0.294625288554977 0.392209924907222 no 1282 0.384140070877701 1843 711240 SGTC_1401 3807-4679 7.6 µM 0.29244986236227 0.392957557192048 no 1283 0.38497134449844 1778 3291456 SGTC_703 3875-0075 71.8 µM 0.290503812418168 0.393626694227124 no 1284 0.385715417296172 1817 2850814 SGTC_2268 7933382 153.85 µM 0.290387471841785 0.393666707177058 no 1285 0.385759913506463 1886 935025 YOR257W CDC31 SGTC_202 3594-0513 34.79 µM 0.287809634502825 0.394553588687065 no 1286 0.386746231007575 1866 708429 SGTC_753 1322-0200 289 µM 0.287762036244266 0.394569969591045 no 1287 0.386764449684979 1811 5403907 SGTC_77 0828-0286 12.516 µM 0.287267710797727 0.394740102328837 no 1288 0.386953672106229 1878 745345 SGTC_892 0929-0076 29 µM 0.286741901841926 0.394921092827979 no 1289 0.387154975566408 1784 5751038 SGTC_192 3455-0609 60.9 µM 0.286741788741656 0.394921131761051 no 1290 0.387155018869576 1822 3769639 SGTC_785 1270-0111 65.3 µM 0.286729881733209 0.394925230575991 no 1291 0.387159577762978 1783 6741994 SGTC_3174 9107204 49.47 µM 0.28358190720443 0.396009281760533 no 1292 0.38836540204514 1876 3938802 SGTC_176 1486-1328 72.834 µM 0.283334503554217 0.396094513050948 no 1293 0.38846021522252 1749 22310231 SGTC_765 1319-0117 244 µM 0.282052508544166 0.396536243600625 no 1294 0.388951624008671 1746 3487746 YGL099W LSG1 SGTC_337 1315-0038 354 µM 0.281458160147486 0.39674108032812 no 1295 0.389179507408265 1809 1626437 SGTC_368 fentichlor 4.58 µM 0.281440540839012 0.396747153096483 no 1296 0.389186263536444 1763 7329 A pesticide. SGTC_1695 st026914 34.495 µM 0.28095002387858 0.396916227434673 no 1297 0.389374365828286 1801 3289191 SGTC_3284 9108171 64.8615 µM 0.280540876835823 0.397057269524608 no 1298 0.389531284407266 1823 8687505 SGTC_529 4076-0302 30.3 µM 0.27974404439528 0.39733199403012 no 1299 0.38983694214208 1792 5816522 SGTC_285 1486-1325 46 µM 0.279131061148158 0.39754336738886 no 1300 0.390072123366724 1886 22310230 SGTC_1205 4161-2785 76 µM 0.277239177858045 0.398195929870177 no 1301 0.390798229294761 1717 3498106 SGTC_987 1497-1013 404 µM 0.277105944413775 0.398241896499749 no 1302 0.390849378756108 1853 1676435 SGTC_954 1189-0853 2.85 µM 0.276238740707756 0.398541123363609 no 1303 0.391182351804023 1888 2828194 SGTC_1503 4585-0012 61.3 µM 0.275892276072642 0.39866068696506 no 1304 0.391315403285216 1896 2922052 SGTC_3229 9132204 49.47 µM 0.27583001879109 0.398682172719877 no 1305 0.391339313058074 1863 17682924 SGTC_166 k072-0058 166.424 µM 0.27291523207674 0.39968844419206 no 1306 0.392459188671231 1961 5846229 SGTC_1009 4106-0057 9.87 µM 0.27218192123701 0.399941710221954 no 1307 0.392741071014055 1962 2928005 SGTC_3082 9117008 49.47 µM 0.271870921808698 0.400049133858307 no 1308 0.392860635200234 1817 41448529 SGTC_2860 9025725 38.96 µM 0.270735249390526 0.400441475485563 no 1309 0.393297331910936 1747 40546248 SGTC_2531 methyl deoxycholate 70.07 µM 0.270323027962115 0.40058391081661 no 1310 0.393455875427069 1794 16667744 Haematoxylin. SGTC_1062 mesoridazine 14.2 µM 0.269854373361642 0.400745861623185 no 1311 0.393636145033318 1831 4078 A neuroleptic. SGTC_2133 5320837 200 µM 0.268857167188573 0.401090518299085 no 1312 0.39401979964723 1919 2841355 SGTC_1368 1852-0141 284 µM 0.267579299139452 0.401532290482686 no 1313 0.394511583489517 1836 2838987 SGTC_2669 eugenol 100 µM 0.267413208814183 0.401589718879592 no 1314 0.394575515239721 1939 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_1028 k015-0029 4.8 µM 0.265913600194564 0.4021083287257 no 1315 0.395152875319474 1787 4588309 SGTC_3141 9094609 49.47 µM 0.265754404956471 0.402163393373091 no 1316 0.395214180170083 1749 25236309 YDL196W YDL196W SGTC_2427 5545055 42.75 µM 0.26567799603891 0.402189823434402 no 1317 0.395243605572478 1845 5372858 SGTC_2588 indole-3-carbinol 100 µM 0.265534862355842 0.402239334984791 no 1318 0.395298728576152 1965 3712 Induces cell cycle arrest. SGTC_815 1582-0027 36.9 µM 0.265516923580935 0.402245540319364 no 1319 0.395305637224654 1873 3128206 SGTC_1448 4255-0083 152 µM 0.265027724584219 0.40241477226131 no 1320 0.395494052060865 1942 5399660 SGTC_2540 epiandrosterone 100 µM 0.264245041811531 0.40268556907516 no 1321 0.395795552871809 1899 441302 A steroid. SGTC_481 bay k-8644 50 µM 0.263814072939173 0.402834697956827 no 1322 0.395961594996871 1800 2303 A calcium channel antagonist. SGTC_1957 st077035 62.4 µM 0.26359883654687 0.402909181861216 no 1323 0.39604452756464 1900 705593 SGTC_3116 9124943 49.47 µM 0.26302336284911 0.403108345443593 no 1324 0.396266285988857 1743 41905195 YPL160W CDC60 SGTC_477 mead ethanolamide 10 µM 0.262170016187127 0.40340372332416 no 1325 0.396595184358462 1877 16061185 SGTC_1901 st060216 58.6 µM 0.261970070257595 0.403472940693541 no 1326 0.396672258519533 1786 688792 SGTC_353 1988-1175 58.3 µM 0.260545138323378 0.403966311691915 no 1327 0.397221650922761 1782 2788357 SGTC_2071 5230951 39.92 µM 0.26043461640374 0.404004585396276 no 1328 0.397264271955055 1959 1799272 SGTC_1423 4048-0112 5.59 µM 0.258898796258757 0.404536534366212 no 1329 0.397856663488121 1943 X1423 SGTC_1364 1653-0028 37.6 µM 0.258187586381801 0.404782929941253 no 1330 0.398131068930137 1844 5718652 SGTC_2103 5378138 10 µM 0.257937391708932 0.404869617782668 no 1331 0.398227613295419 1892 244142 SGTC_88 0180-0332 8.668 µM 0.257577490714565 0.404994325029253 no 1332 0.398366501731187 1853 3101745 SGTC_2951 9072950 58.06 µM 0.256202286002711 0.4054709281591 no 1333 0.398897321776556 1958 16488155 SGTC_2289 7946404 165.07 µM 0.255924341830761 0.405567272007113 no 1334 0.399004629167311 1818 1246120 YPR165W RHO1 SGTC_877 0771-0151 33.1 µM 0.251468317665161 0.407112641906278 no 1335 0.40072602708679 1880 6166523 SGTC_2730 imipramine 71.33 µM 0.249182982971613 0.407905769568245 no 1336 0.401609620983318 1967 3696 A tricyclic antidepressant. SGTC_1811 st050069 61.5 µM 0.248557140610603 0.408123034767267 no 1337 0.401851682481253 2024 3877702 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.247824681545721 0.40837734851669 no 1338 0.402135028699758 1974 688798 SGTC_2000 st075254 36.4 µM 0.245430905326933 0.409208749195595 no 1339 0.403061400822376 1860 17234175 SGTC_145 3737-0113 38.366 µM 0.245395758660558 0.409220959304958 no 1340 0.403075006366812 2001 6849351 SGTC_2285 7945142 200 µM 0.242845825454088 0.410107051791065 no 1341 0.404062417178806 1855 2970608 SGTC_2390 9097792 176.6 µM 0.242046057102711 0.410385063186067 no 1342 0.404372237818824 1800 4497149 SGTC_1174 0739-0097 51.1 µM 0.240868491551153 0.410794484458632 no 1343 0.40482852167122 1883 728447 SGTC_3177 9107506 49.47 µM 0.238995589410272 0.41144586356659 no 1344 0.405554501398695 1992 8897194 SGTC_1293 1000-1278 195 µM 0.238363225428888 0.411665849497765 no 1345 0.405799693666567 1943 678847 SGTC_583 1488-1091 88.9 µM 0.238361144308172 0.411666573521123 no 1346 0.405800500659599 2040 4303273 SGTC_502 l-744,832 89.3 µM 0.237847780346769 0.411845182385449 no 1347 0.405999579247129 2006 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_2569 tetrandrine 100 µM 0.237340447386769 0.412021710897527 no 1348 0.406196342941757 1803 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_2032 5185112 25.99 µM 0.2369126354812 0.412170583582425 no 1349 0.406362283656968 1951 5718189 SGTC_524 r073-0010 27.8 µM 0.236768048725591 0.412220900652307 no 1350 0.406418370121215 1826 2772106 SGTC_1111 tnp00062 510.699 nM 0.236482769097787 0.412320183928429 no 1351 0.40652903820893 2006 676306 SGTC_1342 1486-1464 234 µM 0.2358194513434 0.412551054059103 no 1352 0.406786386894617 1861 3253938 SGTC_1456 k015-0012 13 µM 0.233085504800012 0.413502932515097 no 1353 0.407847505219894 2052 2989616 SGTC_681 1642-0006 26.6 µM 0.232705379998084 0.413635321005806 no 1354 0.40799509563068 1965 4446530 SGTC_1994 st072947 40.9 µM 0.232024811556686 0.413872371435286 no 1355 0.408259371382335 1920 5286565 YDL195W SEC31 SGTC_2972 9093619 59.92 µM 0.229962105009782 0.414591029095183 no 1356 0.409060608209094 1803 25236256 SGTC_76 0433-0009 400.328 µM 0.229325387827555 0.414812922539532 no 1357 0.409308011286457 1853 2841569 SGTC_1907 st060210 83.7 µM 0.229233498181308 0.41484494796753 no 1358 0.409343718948711 1994 688793 SGTC_1197 1601-0112 267 µM 0.228453610220391 0.415116777695432 no 1359 0.40964680811068 1838 7350313 SGTC_973 1325-0077 65.9 µM 0.228020640846263 0.415267706600371 no 1360 0.409815097047248 1979 2835149 SGTC_3149 9097855 49.47 µM 0.227031417566567 0.415612587083129 no 1361 0.41019965613461 1997 25236625 YMR079W SEC14 SGTC_742 0kpi-0133 140 µM 0.226193204387745 0.415904870654764 no 1362 0.410525577886413 2013 2728852 SGTC_1917 st066507 28.5 µM 0.226090950071938 0.415940529755391 no 1363 0.410565341582971 1857 3156428 SGTC_974 1326-0144 138 µM 0.225959312750877 0.415986436596871 no 1364 0.410616532819685 1862 5411856 SGTC_433 pimozide 108 µM 0.224867547981627 0.416367219797886 no 1365 0.411041157864782 1758 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_2302 7771753 200 µM 0.223846176544386 0.416723522458481 no 1366 0.411438498912512 1825 2203047 SGTC_1378 2093-0007 380 nM 0.223056706342088 0.416998973901055 no 1367 0.411745686396822 1886 3618014 SGTC_1624 st003710 6.25 µM 0.222588925009873 0.417162205176133 no 1368 0.411927728391857 2014 24207033 SGTC_3107 9121808 49.47 µM 0.222349678237642 0.417245695336146 no 1369 0.412020841103128 2028 662681 SGTC_358 0075-0058 9.45 µM 0.22217791236671 0.417305638927148 no 1370 0.412087693904117 2132 1069125 SGTC_2156 5649887 115 µM 0.221899807572009 0.417402697206977 no 1371 0.412195940166439 2008 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_303 1348-1668 34.2 µM 0.220639691498366 0.417842539368467 no 1372 0.412686496622057 1943 5380509 SGTC_1911 st060208 74.3 µM 0.217770777144062 0.418844313420518 no 1373 0.41380385728955 1986 688783 SGTC_2336 9001819 198.65 µM 0.216730975411728 0.419207524085708 no 1374 0.414209003406335 1973 2989602 SGTC_2189 6047310 154.431 µM 0.216683561657899 0.419224087714962 no 1375 0.414227479779661 1917 711535 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.216215730613965 0.419387528552606 no 1376 0.414409796144603 1897 6857784 SGTC_2736 butenafine 14.65 µM 0.215562215021528 0.419615863180155 no 1377 0.414664505679787 2006 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2313 7726885 200 µM 0.214897620428849 0.419848096506943 no 1378 0.414923570087752 1919 726423 SGTC_3209 9113616 49.47 µM 0.214798573158741 0.419882709588422 no 1379 0.414962182694625 2092 16649353 SGTC_2346 9031566 143.75 µM 0.214773207254624 0.419891574062723 no 1380 0.414972071475723 2009 4771086 SGTC_2880 9042983 58.44 µM 0.214286267983916 0.420061749758253 no 1381 0.415161912948048 1922 6464714 SGTC_2128 5255449 168.493 µM 0.214257896851952 0.420071665371824 no 1382 0.415172974522618 1922 736008 SGTC_1399 3562-5772 25 µM 0.214223705435752 0.420083615222237 no 1383 0.415186305447704 1936 23847490 SGTC_2150 5556613 200 µM 0.213888799287998 0.420200668328924 no 1384 0.415316887496992 1946 743190 SGTC_382 3229-0966 23.2 µM 0.211955921995949 0.420876366220974 no 1385 0.416070711067284 2015 5722370 SGTC_1982 st072467 71.9 µM 0.210160643788046 0.421504170940925 no 1386 0.416771147641777 1897 3163533 SGTC_3075 9116269 49.47 µM 0.210095196748009 0.421527061402775 no 1387 0.416796687131266 1944 17015205 YNL244C SUI1 SGTC_2994 9053520 71.4286 µM 0.208482297805364 0.422091265280586 no 1388 0.417426201637731 2010 4647384 SGTC_1191 1487-1166 10.6 µM 0.206957822748962 0.422624684875101 no 1389 0.41802139894944 2006 3955771 SGTC_1113 artemisinin 1.17947 µM 0.206940475559141 0.42263075554099 no 1390 0.418028172856369 2058 2240 An anti-malaria and mitochondrial poison. SGTC_1484 3473-2379 286 µM 0.204427809238002 0.423510258937863 no 1391 0.419009600194269 2063 671917 SGTC_587 k089-0003 57 µM 0.203697425718592 0.423765985279402 no 1392 0.419294977000687 2061 9659696 SGTC_385 1494-0393 12.4 µM 0.199817709367156 0.425124911028318 no 1393 0.420811575280102 1979 3090647 SGTC_803 4488-1585 147 µM 0.199638745818357 0.42518761715345 no 1394 0.420881561469633 2032 747204 SGTC_1247 0448-0043 5.84 µM 0.199002855983024 0.425410438649448 no 1395 0.421130255262761 1927 3089013 YGL099W LSG1 SGTC_2821 7996764 71.43 µM 0.198595698354612 0.425553122847017 no 1396 0.421289509402243 1972 2987135 SGTC_770 0389-1121 67.2 µM 0.196876485829585 0.426155710456137 no 1397 0.421962097563763 2061 6753108 SGTC_233 rapamycin 362 pM 0.194386027897013 0.427028926703816 no 1398 0.422936814693089 2074 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_2123 5259487 200 µM 0.192735249705874 0.42760792783116 no 1399 0.423583157861874 2030 2173474 SGTC_3355 9151058 44.0485 µM 0.19263894282504 0.427641711751942 no 1400 0.423620872076765 2079 17015728 SGTC_3348 9149464 3.537 µM 0.192029200999138 0.42785561811263 no 1401 0.423859665988422 2077 1951442 SGTC_1767 st044992 70.3 µM 0.191218270795395 0.428140137146284 no 1402 0.424177294850487 1932 9600693 SGTC_132 0417-1715 25.805 µM 0.191206013810584 0.428144437859454 no 1403 0.424182096100907 2105 6769098 SGTC_2080 5212524 12.4 µM 0.190096725162786 0.428533698740986 no 1404 0.424616668117154 2117 260183 SGTC_3050 9093513 49.47 µM 0.189433206039162 0.428766567738025 no 1405 0.424876650469658 2008 25236664 SGTC_1203 3992-3522 103 µM 0.185170878652667 0.430263064183551 no 1406 0.426547504773468 2117 5322312 SGTC_438 sphingosine 6.67 µM 0.18480169057839 0.430392733008043 no 1407 0.426692290905071 1808 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_3081 9117243 49.47 µM 0.182657831039603 0.431145862311159 no 1408 0.42753325248545 2079 45595589 SGTC_2866 9034245 58.44 µM 0.181932313218554 0.431400790678362 no 1409 0.427817922690446 2118 6462273 SGTC_1985 st071382 65.5 µM 0.181076635897742 0.431701490477606 no 1410 0.428153711642442 2067 6123237 SGTC_1830 st055982 50.3 µM 0.180284826052101 0.431979781405284 no 1411 0.428464483773901 2117 455313 An antimicrobial agent. SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.180177347329803 0.43201755867744 no 1412 0.428506670800191 2042 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_3350 9150499 3.57 µM 0.178802966975581 0.432500688888281 no 1413 0.429046207759755 2054 4910996 YPR165W RHO1 SGTC_2471 5466956 24.79 µM 0.178359267367426 0.43265668235431 no 1414 0.429220418135761 2015 724419 SGTC_58 0957-0393 9 µM 0.177109022951627 0.433096292785019 no 1415 0.429711377338584 1959 6997992 SGTC_229 benomyl 22.8748 µM 0.177064967882692 0.433111784923831 no 1416 0.429728679336525 1995 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.176964677529153 0.433147052805676 no 1417 0.429768067441122 2047 229346 A bile salt which induces apoptosis. SGTC_2663 amphotericin b 100 µM 0.174658658919091 0.43395812847572 no 1418 0.430673926882287 2004 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_830 4076-0286 57.8 µM 0.173367644399706 0.434412327336699 no 1419 0.431181228000279 2005 6866659 SGTC_2767 sibutramine 71.45 µM 0.170675410293581 0.435359774785398 no 1420 0.432239499421609 2110 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.170118615016113 0.435555767941534 no 1421 0.432458427115566 1941 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_1739 st037196 92.5 µM 0.167895075308745 0.436338616154855 no 1422 0.433332912234499 2124 612214 SGTC_3323 9138564 53.9225 µM 0.166717486468848 0.436753314575257 no 1423 0.433796172945239 2108 43912313 YNL103W MET4 SGTC_1717 st033143 58.0435 µM 0.165385845453563 0.437222347573766 no 1424 0.434320146976166 2100 674616 SGTC_2796 7949634 45.45 µM 0.164538034526216 0.437521011084687 no 1425 0.4346538037578 2020 2971588 SGTC_3062 9077494 49.47 µM 0.162773180808528 0.438142840838455 no 1426 0.435348512615468 2075 16459633 SGTC_286 k060-0067 22.9 µM 0.16204088050877 0.438400904954088 no 1427 0.435636830633051 2030 5985051 SGTC_32 0928-0142 34.1 µM 0.161323905321392 0.438653593847559 no 1428 0.435919148064603 2114 2244242 SGTC_2853 9015042 58.44 µM 0.160606414663202 0.438906489447384 no 1429 0.436201701160256 2050 6457456 SGTC_1199 1638-0010 4.46 µM 0.158925905683991 0.43949891980172 no 1430 0.436863625149511 1964 3111136 SGTC_1607 st000305 50.6 µM 0.158613680038604 0.439609003773903 no 1431 0.436986625067434 2123 5457690 SGTC_2220 6782180 200 µM 0.15710537851458 0.440140863706358 no 1432 0.43758089939108 2123 833803 SGTC_2619 obliquin 87.91 µM 0.157051493549862 0.4401598667216 no 1433 0.437602132806512 2078 6708593 A bioactive alkalod. YER133W GLC7 SGTC_1480 1070-0044 41.2 µM 0.155596733574337 0.440672952805146 no 1434 0.43817544990678 2136 3124987 SGTC_1556 plumbagin 1.48 µM 0.154348288556173 0.44111335216514 no 1435 0.438667562350367 2124 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2372 9071633 200 µM 0.153157441775589 0.441533501143609 no 1436 0.439137059088319 2167 21321366 SGTC_1518 st038567 90.8 µM 0.151831579711671 0.442001362973402 no 1437 0.439659886936912 2138 77966 SGTC_2556 citropten 84.59 µM 0.15054362939578 0.442455924235547 no 1438 0.440167865823395 2093 2775 A potential DNA crosslinker. SGTC_199 4063-0024 41.6 µM 0.14972642273747 0.442744383454782 no 1439 0.440490230418262 2118 306215 SGTC_3235 9132602 49.47 µM 0.149715203147636 0.44274834397932 no 1440 0.440494656499732 2075 4912240 SGTC_136 0097-0015 404.482 µM 0.149291334106146 0.442897974290659 no 1441 0.440661876512809 2169 4861337 SGTC_21 0849-0113 22.993 µM 0.148882261810068 0.443042388915619 no 1442 0.440823269116166 2056 1560156 SGTC_2192 5915882 198.485 µM 0.14846127315179 0.443191018269578 no 1443 0.44098937338318 2120 2876149 SGTC_3114 9122766 49.47 µM 0.146547650171632 0.443866720159095 no 1444 0.441744538261263 2005 17176985 SGTC_2151 5563267 85.4165 µM 0.146469569159234 0.443894294109503 no 1445 0.441775355554107 2024 5310824 SGTC_2913 7966556 36.57 µM 0.145955461219118 0.444075855739694 no 1446 0.441978274303546 2136 2976516 SGTC_2402 5553605 200 µM 0.145657005419652 0.444181263353414 no 1447 0.442096081997254 2100 6758546 SGTC_2908 7930301 100 µM 0.144177939259103 0.444703693082451 no 1448 0.442679980420951 2134 2223178 SGTC_3155 9099265 49.47 µM 0.143914536840664 0.444796741116636 no 1449 0.442783978224115 2093 25236499 SGTC_578 3460-0051 92 µM 0.143815958005566 0.444831565295522 no 1450 0.442822900605655 2156 2876744 SGTC_584 0986-0246 15.4 µM 0.143341123871066 0.444999312220048 no 1451 0.443010389499609 2172 53315 YDR232W HEM1 SGTC_375 3970-0961 9.27 µM 0.142764214083478 0.445203133148903 no 1452 0.443238200269359 2087 2898222 SGTC_523 1934-0222 13.7 µM 0.140724175175256 0.445923990124838 no 1453 0.444043923057333 1988 1361595 SGTC_1436 4092-1007 8.32 µM 0.140290580509241 0.446077225879457 no 1454 0.444215203194639 2123 2881121 SGTC_26 0302-0163 425.158 µM 0.139781903104985 0.446257006727634 no 1455 0.44441615606685 2065 3100915 SGTC_2309 7664088 163.95 µM 0.13868616993464 0.446644307017887 no 1456 0.444849073636444 2195 704922 SGTC_1618 st003135 44.5 µM 0.138170242032854 0.446826685692688 no 1457 0.445052936453517 2164 1270615 SGTC_746 1095-0025 46.6 µM 0.13741144577829 0.447094937887935 no 1458 0.445352792221896 2143 6749286 SGTC_549 1661-1316 519 µM 0.136408934370993 0.44744938617748 no 1459 0.445749005546062 2185 2857282 SGTC_909 3448-9333 149 µM 0.135807320747087 0.447662113073915 no 1460 0.445986801782916 2054 3344074 SGTC_2895 9054447 58.44 µM 0.135355961767575 0.447821720735262 no 1461 0.446165220521953 2053 2697450 SGTC_2206 7254556 146.969 µM 0.13528342134332 0.447847372963249 no 1462 0.446193896212355 2152 4398905 SGTC_332 4112-0506 40.9 µM 0.134776141759995 0.448026766638227 no 1463 0.446394434909897 2057 2790355 SGTC_1534 6-azauridine 81.6 µM 0.132966289025999 0.448666886909418 no 1464 0.4471100205898 2148 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_492 tmb-8 126 µM 0.129895239411914 0.449753380300388 no 1465 0.448324655388885 2166 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_1671 st016596 74.5 µM 0.129741245683245 0.449807871065067 no 1466 0.44838557450119 2149 2829167 SGTC_369 0957-0393 4.5 µM 0.129626454343744 0.449848490658742 no 1467 0.448430986145598 2046 6997992 SGTC_661 1304-0007 33.6 µM 0.12950208260516 0.449892500926292 no 1468 0.448480188574442 2063 3117130 SGTC_806 3966-4455 5.86 µM 0.129386379547188 0.449933444242025 no 1469 0.44852596231726 2014 714982 SGTC_344 k064-0035 6.43 µM 0.12825071093584 0.450335346357226 no 1470 0.448975284931293 2004 5088750 SGTC_1729 st035615 45.989 µM 0.126921394588523 0.450805843205551 no 1471 0.449501306574368 2029 17385451 SGTC_2171 5739187 198.077 µM 0.124176581177022 0.451777557634231 no 1472 0.450587732109983 2119 2262761 SGTC_2993 9054257 71.4286 µM 0.122921381525249 0.452222018038637 no 1473 0.451084677007988 2173 6470217 YGL055W OLE1 SGTC_291 SEC14.278 35.5 µM 0.122204697794494 0.452475819332834 no 1474 0.451368453020571 2165 1068044 SGTC_2989 9073649 71.4286 µM 0.121904222200819 0.452582233412445 no 1475 0.451487435868672 2219 21367202 SGTC_260 nsc-65238 3.989 µM 0.121187899978598 0.452835934196834 no 1476 0.451771103948031 2171 3246252 SGTC_2290 7904846 200 µM 0.12118215512431 0.452837968937406 no 1477 0.451773379045988 2067 2962154 SGTC_91 0417-1751 58.384 µM 0.118847601613465 0.453664934423091 no 1478 0.452698047637037 2201 6795624 SGTC_1819 st053448 58.6 µM 0.11872429923009 0.453708617264796 no 1479 0.452746892350608 2116 2857616 SGTC_931 2812-0076 566 µM 0.1183892487279 0.453827319809116 no 1480 0.452879622070745 2143 3450959 SGTC_655 k060-0012 42 µM 0.118257512617808 0.453873992743644 no 1481 0.452931810562728 2098 5994525 SGTC_3335 9143315 29.6265 µM 0.11813855578556 0.453916138640797 no 1482 0.452978937122869 2073 4899691 SGTC_2386 9075165 157.42 µM 0.11768660374809 0.45407626804292 no 1483 0.453157990835712 2111 16452277 SGTC_2255 7941087 197.44 µM 0.116118032755482 0.454632080196365 no 1484 0.453779498708174 2208 935561 SGTC_1795 st049545 62.3 µM 0.115481631820909 0.454857609808915 no 1485 0.454031689374685 2247 5291882 SGTC_1056 3448-1962 115 µM 0.115322482315581 0.454914011950502 no 1486 0.4540947594676 2110 715507 SGTC_2121 5257820 149.641 µM 0.114945676164314 0.455047554622954 no 1487 0.454244090330487 2217 791256 SGTC_2775 cyproheptadine 69.59 µM 0.114845553553076 0.455083039614807 no 1488 0.454283770696739 2214 2913 A selective serotonin reuptake inhibitor. SGTC_2811 7967822 32.47 µM 0.113797668551551 0.455454447612118 no 1489 0.45469909340726 2165 2232244 SGTC_119 0121-0043 24.815 µM 0.113417371625407 0.455589248117788 no 1490 0.454849834004238 2209 1092378 SGTC_1682 st012968 530 nM 0.113028110736592 0.455727231295442 no 1491 0.455004134434857 2022 24207270 SGTC_1966 st070145 16.1 µM 0.112994246482287 0.455739235573122 no 1492 0.455017558321647 2177 3748532 SGTC_819 1013-0258 27.7 µM 0.112958065769383 0.455752061038947 no 1493 0.455031900515975 2121 5753198 SGTC_1805 st050013 60.3 µM 0.111972797865696 0.456101339936448 no 1494 0.455422487532401 2169 4037144 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 0.111773419293789 0.456172024064641 no 1495 0.455501531880069 2211 5355888 SGTC_2523 spermine 47.74 µM 0.108185539022927 0.457444242156118 no 1496 0.456924257906661 2196 1103 A DNA binding polyamine. SGTC_2491 paeonol 100 µM 0.10792751761404 0.457535750333408 no 1497 0.457026594357129 2101 11092 Increases levels of cortical cytochrome oxidase. SGTC_486 niguldipine 82 µM 0.107058961506427 0.457843803251029 no 1498 0.457371101982199 2227 1236 A calcium channel blocker. SGTC_2620 irigenin 100 µM 0.10616648420802 0.458160366736307 no 1499 0.45772513117491 2173 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_1094 duloxetine 25.4 µM 0.104312849797693 0.458817939154097 no 1500 0.458460540440708 2178 60834 A selective serotonin reuptake inhibitor. SGTC_1307 1187-1599 12.2 µM 0.104124026451472 0.458884930144297 no 1501 0.458535462070102 2129 1538471 SGTC_1724 st037281 8.293 µM 0.104005805981386 0.458926873149573 no 1502 0.458582370527363 2167 574124 YDL195W SEC31 SGTC_2749 bexarotene 57.39 µM 0.103620380750047 0.459063619921125 no 1503 0.458735306614542 2099 82146 An retinoic acid receptor inhibitor. SGTC_3056 9094900 49.47 µM 0.102441296109656 0.459481982732514 no 1504 0.459203203256305 2131 25236784 SGTC_2251 lansoprazole 556 µM 0.101109557263229 0.459954564247863 no 1505 0.45973174566498 2027 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_1467 k284-1082 293 µM 0.100978010651246 0.460001248025892 no 1506 0.459783957949117 2250 3334705 SGTC_2949 9072542 2.23 µM 0.0999608400550175 0.46036224408804 no 1507 0.460187707393323 2143 16457352 SGTC_1022 4477-0945 21.3 µM 0.0998863658762996 0.460388676423736 no 1508 0.460217270334045 2173 4648966 SGTC_187 1488-2104 32.728 µM 0.0983485182718548 0.460934527428978 no 1509 0.460827776439277 2205 2852859 SGTC_1355 1499-0035 1.68 µM 0.0980917889910146 0.461025659349439 no 1510 0.460929703759507 2175 1548538 SGTC_2069 5228469 200 µM 0.0977030512578581 0.461163654578924 no 1511 0.461084046299271 2148 2835210 SGTC_2153 5569715 200 µM 0.0973979479808738 0.461271964286891 no 1512 0.461205187128328 2233 2054701 SGTC_2999 9069765 71.4286 µM 0.0968727957639201 0.461458396681412 no 1513 0.461413706505459 2186 2097066 SGTC_1098 clofazimine 15.1 µM 0.0967064334680764 0.46151745812859 no 1514 0.461479765306228 2210 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_1269 0831-0796 3.05 µM 0.0955831930807997 0.46191624973319 no 1515 0.46192580702706 2238 927758 SGTC_2106 5357045 167.29 µM 0.0952500057286961 0.462034550866032 no 1516 0.462058125838556 2196 668842 SGTC_986 1493-0483 84 µM 0.0931889030880761 0.462766437945735 no 1517 0.462876745039475 2240 40079 SGTC_1792 st045773 43.6 µM 0.0924532912553387 0.463027680625686 no 1518 0.463168950195541 2118 2919270 SGTC_335 4077-0256 27.6 µM 0.0921348924871642 0.463140760630814 no 1519 0.463295433073648 2233 3121989 SGTC_100 0086-0128 49.5915 µM 0.0912712450545001 0.463447501838329 no 1520 0.463638532861331 2128 93297 SGTC_1553 gossypol 38.6 µM 0.089673788077724 0.464014926937948 no 1521 0.464273223043354 2235 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1548 st061468 90.8 µM 0.0880386416374826 0.464595815338879 no 1522 0.46492298188944 2245 390799 SGTC_3272 9137413 49.47 µM 0.0870210504310987 0.46495735442536 no 1523 0.465327389876777 2266 17614870 SGTC_157 1348-1695 65.819 µM 0.0868294527035861 0.465025430259226 no 1524 0.465403538078983 2262 5380510 SGTC_2259 7964009 200 µM 0.086226650860101 0.465239616075215 no 1525 0.465643122639323 2194 313134 SGTC_289 k017-0060 526 µM 0.0843656919722676 0.465900909896706 no 1526 0.46638284192465 2231 5512909 SGTC_2785 7756463 72.73 µM 0.0840727926208716 0.466005000632009 no 1527 0.466499278192039 2228 2201551 SGTC_133 0724-0033 378.92 µM 0.0829282269375873 0.466411779258887 no 1528 0.466954304743972 2265 280309 SGTC_1198 1612-1005 86.7 µM 0.0824635503997497 0.46657693533216 no 1529 0.46713905107469 2239 6998509 SGTC_981 1488-1094 54.9 µM 0.0822011413134816 0.466670203731013 no 1530 0.467243382940951 2245 3449522 SGTC_1897 st060201 15 µM 0.0814463666469274 0.466938484446605 no 1531 0.467543488155901 2087 611878 SGTC_1374 2889-5571 141 µM 0.0808885222540846 0.467136776984611 no 1532 0.467765303984024 2180 2853281 SGTC_3325 9138760 55.175 µM 0.0807438131300217 0.467188216927686 no 1533 0.46782284635288 2189 43844959 SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.0798309838476964 0.46751271415214 no 1534 0.468185840705574 2265 3256 An antibiotic and ribosome inhibitor. SGTC_1923 st058458 19.1 µM 0.0794518627032029 0.467647492434689 no 1535 0.468336609255531 2294 3534982 SGTC_2960 9079389 5.97 µM 0.0792397088789124 0.467722915139162 no 1536 0.468420980377468 2273 16457355 SGTC_1353 1498-1206 8.11 µM 0.0761884267770855 0.468807801824419 no 1537 0.46963459501058 2255 6756808 SGTC_2315 7733312 200 µM 0.0745604401756429 0.469386729525188 no 1538 0.470282225318343 2221 726316 SGTC_2975 9084847 53.72 µM 0.0741682887877258 0.469526192052141 no 1539 0.470438239106657 2117 27211724 SGTC_1481 3346-2004 36 µM 0.0741221299867263 0.469542607956307 no 1540 0.470456603255981 2283 2770522 SGTC_766 1391-0721 126 µM 0.0740137940947644 0.469581136708478 no 1541 0.470499704633013 2265 1020919 YIL115C NUP159 SGTC_2172 5754775 163.918 µM 0.0725080001619402 0.470116689035315 no 1542 0.471098819510298 2201 2263357 SGTC_1588 farnesol 29.9 µM 0.071446991728549 0.47049408098553 no 1543 0.471521005574496 2277 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2907 7721985 69.9 µM 0.0709758682932026 0.470661664223242 no 1544 0.471708480677796 2226 3267881 SGTC_1182 1222-0449 220 µM 0.0694027997853259 0.471221257627945 no 1545 0.472334500194445 2228 658318 SGTC_866 0495-0101 262 µM 0.0685603700903861 0.471520961654713 no 1546 0.472669782345213 2098 635694 SGTC_2338 7999974 200 µM 0.0662468713068731 0.47234409784077 no 1547 0.473590640399683 2274 315925 SGTC_3290 9121031 71.43 µM 0.0657180096290745 0.472532282013986 no 1548 0.473801166899064 2240 17014854 SGTC_1732 st034308 51.822 µM 0.0647167657018412 0.47288857011572 no 1549 0.474199756853185 2240 830119 SGTC_3309 9129340 25.759 µM 0.0639116569680943 0.473175080147888 no 1550 0.474520285169304 2236 17158987 SGTC_1526 st051518 75 µM 0.0633077428513553 0.473390001171879 no 1551 0.47476072511485 2118 673993 SGTC_2746 daunorubicin 9.88 µM 0.063050582862549 0.473481521652866 no 1552 0.474863112557681 2290 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2648 atorvastatin 78.68 µM 0.0625703833796788 0.473652423240392 no 1553 0.475054306914515 2294 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.0620771328483781 0.47382797470639 no 1554 0.475250703606658 2233 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_898 1000-0849 28.3 µM 0.0611778674491018 0.474148042884824 no 1555 0.475608777963621 2287 6751807 SGTC_25 0118-0223 35.662 µM 0.0610092641537993 0.474208054340623 no 1556 0.475675915536731 2279 5333628 SGTC_1647 st011722 22.4 µM 0.0604616706502813 0.474402964901356 no 1557 0.475893971182413 2279 2854783 SGTC_1636 st007707 68.9 µM 0.0600494465522096 0.474549696088779 no 1558 0.476058126530253 2282 403051 SGTC_2051 5263410 176 µM 0.0585241909627564 0.475092640752062 no 1559 0.476665546956724 2319 227584 SGTC_1057 3448-5381 134 µM 0.0575793958952836 0.475428982365221 no 1560 0.47704183106626 2293 5497911 SGTC_1788 fluconazole 20 µM 0.0568401367965151 0.475692166577587 no 1561 0.477336270531849 2173 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_1417 3966-0327 90.4 µM 0.0566910846713286 0.475745232030185 no 1562 0.477395637998498 2261 651118 SGTC_2893 9048488 25.97 µM 0.0562317427554369 0.475908769378767 no 1563 0.477578597048983 2251 6467338 SGTC_2684 capsaicin 100 µM 0.0556311744438947 0.476122593016242 no 1564 0.477817814668752 2254 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_2783 7738165 71.43 µM 0.0554504761864545 0.476186929358637 no 1565 0.477889791741048 2231 17201110 SGTC_258 haloperidol 50.781 µM 0.0550643785651658 0.476324398776659 no 1566 0.478043587427676 2263 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_645 0845-0943 5.41 µM 0.0545458620631768 0.476509020147981 no 1567 0.478250135154552 2252 1885106 SGTC_1488 4013-0813 75.9 µM 0.0544100536441673 0.476557376505776 no 1568 0.478304234535927 2264 2910057 SGTC_2938 9059746 27.26 µM 0.0540020158494579 0.476702665755113 no 1569 0.478466779085755 2270 6471769 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.0539614187957909 0.476717121241292 no 1570 0.478482951386496 2309 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_2056 5235370 200 µM 0.051591919477422 0.477560886760577 no 1571 0.479426929044828 2274 5511916 SGTC_1725 st036284 20.55 µM 0.0515686399630056 0.477569176971309 no 1572 0.479436203881218 2308 707914 SGTC_542 3381-0244 89.3 µM 0.050093563257283 0.478094495230554 no 1573 0.480023914538435 2319 1112843 SGTC_1107 amlodipine 47 µM 0.0498952824091536 0.478165111802406 no 1574 0.480102918357554 2285 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_2116 5511452 16.8835 µM 0.0491676034846795 0.478424276280254 no 1575 0.480392864350949 2271 870744 SGTC_3111 9122088 49.47 µM 0.0486603955960025 0.478604924907601 no 1576 0.480594969100033 2322 16876704 SGTC_1366 1683-0113 21.9 µM 0.0485740148147531 0.478635690975326 no 1577 0.480629389343424 2314 708623 SGTC_783 0848-0141 92.7 µM 0.0485392632299353 0.478648068412754 no 1578 0.48064323688579 2319 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_1015 4130-4525 82 µM 0.0477584243634842 0.478926184422878 no 1579 0.480954385636975 2276 1363237 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.047178738622794 0.479132661175296 no 1580 0.481185386385299 2286 688803 SGTC_1288 0973-0013 65.5 µM 0.0467185338809431 0.479296584292648 no 1581 0.48136877928646 2281 4315430 SGTC_3253 9135987 49.47 µM 0.0462891295365572 0.47944953958833 no 1582 0.481539901698226 2308 4182430 SGTC_2148 5546263 113.568 µM 0.0458994886384541 0.479588333627979 no 1583 0.481695180878321 2284 792097 SGTC_541 4513-1321 94 µM 0.0457668761194294 0.479635572117569 no 1584 0.481748030080223 2221 747515 SGTC_1420 4'-methoxyflavone 42 µM 0.0446178243035228 0.480044892832021 no 1585 0.482205967534004 2323 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_1849 st056239 19.2 µM 0.0441804970173754 0.480200685194222 no 1586 0.482380263998698 2272 5393181 SGTC_2550 chrysin dimethyl ether 71.87 µM 0.0440073715988528 0.480262359790766 no 1587 0.482449263937828 2332 88881 An O-methylated flavonoid and antioxidant. SGTC_2565 isoliquiritigenin 100 µM 0.0438363830505254 0.480323273607558 no 1588 0.482517412733437 2175 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_864 0469-0573 172 µM 0.0435583968067243 0.480422305799354 no 1589 0.482628207369525 2296 689425 SGTC_2700 st077718 96.8 µM 0.0431845352881323 0.480555495321486 no 1590 0.482777216320329 2283 904970 SGTC_850 0388-0143 75.9 µM 0.0428384529491482 0.480678790345258 no 1591 0.482915155545134 2301 67273 SGTC_757 1066-0008 322 µM 0.0420616174709507 0.480955551859163 no 1592 0.483224788948259 2306 6842497 SGTC_3211 9128781 49.47 µM 0.0406843245153781 0.481446259555044 no 1593 0.48377377923668 2172 17194361 SGTC_1164 k060-0068 93.7 µM 0.0406045597803966 0.481474679336867 no 1594 0.483805574488679 2336 5963676 SGTC_1652 st011932 78 µM 0.0403221203579396 0.481575311866546 no 1595 0.483918159311294 2334 1551076 SGTC_198 3454-2873 16.191 µM 0.0396276012028031 0.481822772455993 no 1596 0.484195011069772 2303 710957 SGTC_2486 5283202 22.39 µM 0.0386565923574221 0.482168759401336 no 1597 0.48458209090081 2285 1377751 SGTC_1319 1306-0155 43.7 µM 0.03751457777597 0.482575695761676 no 1598 0.485037358472211 2342 3122360 SGTC_2173 5763948 167 µM 0.0371889571089268 0.482691728175498 no 1599 0.48516717173672 2347 2867177 SGTC_1075 aripiprazole 15.2 µM 0.036317734214341 0.483002188917659 no 1600 0.485514504704659 2335 60795 An atypical antipschotic. YIL048W NEO1 SGTC_769 0302-0231 76 µM 0.0352718866063935 0.483374890865479 no 1601 0.485931470307316 2327 571869 YER009W NTF2 SGTC_638 3970-0837 4.09 µM 0.0347783983641613 0.48355075714317 no 1602 0.486128222908838 2317 4118451 YLR208W SEC13 SGTC_3127 9126946 49.47 µM 0.0339926991708136 0.483830766336406 no 1603 0.486441486277963 2239 27243249 SGTC_2607 solasodine 47.35 µM 0.0328942944904642 0.484222231529649 no 1604 0.4868794413362 2306 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_3033 9090887 49.47 µM 0.0324289777612465 0.484388072378532 no 1605 0.487064976862168 2341 19325384 SGTC_2414 st077232 92.9 µM 0.032338256091664 0.484420406280488 no 1606 0.487101150599253 2297 729801 SGTC_497 capsazepine 133 µM 0.0318919258873393 0.4845794832916 no 1607 0.487279118787301 2339 2733484 A calcium channel blocker. SGTC_1447 4239-0816 81.9 µM 0.0318755786380352 0.484585309678428 no 1608 0.487285637082211 2327 1341554 SGTC_2589 lobaric acid 100 µM 0.030779213510638 0.484976076895613 no 1609 0.4877228088903 2336 73157 A novel microtubule depolymerizer. SGTC_1018 4259-0013 28.1 µM 0.0298154100909403 0.485319608306992 no 1610 0.488107134377669 2288 6801262 SGTC_3252 9135871 49.47 µM 0.0283985441974212 0.48582464587649 no 1611 0.488672142648254 2344 17682838 SGTC_639 0833-0042 114 µM 0.0283887338077532 0.485828142840462 no 1612 0.488676054850156 2325 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_846 0335-0850 148 µM 0.028264832808782 0.485872308083987 no 1613 0.488725464369957 2360 6819598 SGTC_1527 coumarin 137 µM 0.0275343752275302 0.486132687511333 no 1614 0.489016761383584 2320 323 A hepatotoxic, DNA x-linker. SGTC_2036 5160441 105 µM 0.0266465397414933 0.486449173927517 no 1615 0.48937082653859 2329 134534 YIL048W NEO1 SGTC_1772 st048439 82.2 µM 0.0262109079219453 0.486604466588962 no 1616 0.489544557804442 2307 2927068 YDL195W SEC31 SGTC_3043 9092303 49.47 µM 0.0257816972979809 0.486757472229513 no 1617 0.48971573021863 2354 25236084 SGTC_939 1165-0479 45.3 µM 0.025536466010629 0.486844893519472 no 1618 0.489813531146585 2373 1377347 SGTC_1491 4138-0063 26.5 µM 0.0245565862134684 0.487194212294485 no 1619 0.490204324014782 2371 23883227 SGTC_709 3807-1509 243 µM 0.0240033135188205 0.487391453639805 no 1620 0.490424982831921 2364 1886677 YPL242C IQG1 SGTC_2524 avocatin b 10.57 µM 0.0239614040245649 0.487406394472719 no 1621 0.490441697493689 2351 6710748 SGTC_3304 9125678 46.087 µM 0.0233929117980289 0.487609065021073 no 1622 0.490668429513103 2356 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_1703 st026983 48.3 µM 0.0220070999253223 0.488103127739546 no 1623 0.491221145994533 2371 1104023 SGTC_2054 5233173 129 µM 0.0219076554436817 0.488138581899932 no 1624 0.491260809040342 2344 6889 SGTC_3054 9094397 49.47 µM 0.0210061873218908 0.488459979494645 no 1625 0.491620359998323 2368 2598354 SGTC_1460 k062-0059 9.15 µM 0.0209546157658466 0.488478366367961 no 1626 0.491640929544872 2338 1373085 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.0208542586175329 0.488514146901496 no 1627 0.491680957507482 2372 165521 SGTC_1606 st000094 49.2 µM 0.0207432261370776 0.488553733640121 no 1628 0.491725243478592 2368 1242210 SGTC_2826 7992541 19.48 µM 0.0196680676622147 0.488937068845323 no 1629 0.492154082082185 2382 2985066 SGTC_3009 9080819 71.4286 µM 0.0193932200484457 0.489035064208339 no 1630 0.492263709505173 2352 17027216 SGTC_588 3970-1144 52.9 µM 0.0188706852566597 0.489221372855157 no 1631 0.492472132576019 2362 1888707 SGTC_2934 9036370 36.88 µM 0.0188156431691294 0.489240998129726 no 1632 0.492494087293913 2357 6462800 SGTC_1872 amphotericin b 148 nM 0.0176702458596366 0.489649395760378 no 1633 0.49295095865269 2366 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_1387 3342-1166 1.8 µM 0.017281751326984 0.489787918081736 no 1634 0.493105921880988 2340 3418228 SGTC_1144 3486-0183 12.5 µM 0.0161539494244406 0.490190056109749 no 1635 0.493555786850001 2363 6744069 SGTC_2774 tamoxifen 10.92 µM 0.0147784755110034 0.490680519499234 no 1636 0.494104455880651 2384 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_2585 alliin 100 µM 0.0147580561679798 0.490687800690553 no 1637 0.494112601131626 2369 87310 A garlic compound which reacts with lipids. SGTC_997 3996-0078 137 µM 0.0141829517929872 0.490892874419771 no 1638 0.494342010559387 2371 735687 SGTC_1921 5740136 50 µM 0.0137009531325585 0.491064749882339 no 1639 0.494534281514734 2378 1774243 SGTC_531 3788-1495 174 µM 0.0131389874576937 0.491265142802174 no 1640 0.494758453192547 2385 2896655 SGTC_3281 9140613 49.47 µM 0.0125806474471649 0.491464245019661 no 1641 0.494981180209202 2352 16013766 SGTC_2432 5630864 12.22 µM 0.0122807747058303 0.491571179537221 no 1642 0.495100802881454 2375 5714970 SGTC_995 3931-2021 34.6 µM 0.0114437491010542 0.491869665764217 no 1643 0.495434704282227 2364 730143 SGTC_2610 ononetin 44.17 µM 0.010611366926857 0.492166500642939 no 1644 0.495766756524823 2366 259632 SGTC_2381 9035592 200 µM 0.0078788319928296 0.493140976493486 no 1645 0.496856833317114 2366 4749657 SGTC_2906 7926292 26.41 µM 0.00746347691057906 0.493289104035644 no 1646 0.497022531144162 2378 2966319 SGTC_3244 9134489 49.47 µM 0.00743689134979024 0.493298585241299 no 1647 0.497033136954066 2376 16584271 SGTC_740 k014-0057 261 µM 0.00593417536550359 0.493834504673008 no 1648 0.497632620441715 2383 4012779 SGTC_395 anisomycin 6.25 µM 0.00576976339937627 0.493893140243171 no 1649 0.497698210203245 2385 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_1266 0828-0227 32.9 µM 0.00497389558946333 0.494176978863946 no 1650 0.49801571093283 2394 3913820 SGTC_459 nigericin 15.3 µM 0.00486449179056996 0.494215996913177 no 1651 0.498059356205745 2386 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_1866 st057638 64 µM 0.00445705843154434 0.494361305466895 no 1652 0.498221896832552 2395 688802 SGTC_2258 7960471 200 µM 0.00306995481922995 0.494856012769495 no 1653 0.498775267147462 2390 2974708 SGTC_1315 1237-0019 3.69 µM 0.00251795280899594 0.495052885255693 no 1654 0.49899548322589 2399 825140 SGTC_3083 9117465 49.47 µM 0.00193568476723221 0.495260553480032 no 1655 0.499227773987061 2401 16420915 SGTC_2385 9074692 200 µM 0.00101416565978786 0.495589219555407 no 1656 0.499595406508336 2398 17046906 SGTC_2974 9094440 9.66 µM 0.000144598002603539 0.495899359541057 no 1657 0.499942313743301 2405 25236134 SGTC_1218 1348-1416 30.7 µM -0.000984687363888535 0.496302134111967 no 1658 0.49960716664105 2407 6787668 SGTC_411 enrofloxacin 100 µM -0.0014312523566592 0.496461408489333 no 1659 0.499429013115947 2408 71188 A bacterial gyrase inhibitor. SGTC_2318 6029776 164 µM -0.00207924840855979 0.496692527395396 no 1660 0.49917050049606 2413 818325 SGTC_1344 1488-0097 29.1 µM -0.00211398079060864 0.496704915327206 no 1661 0.499156644310817 2410 747966 SGTC_2030 5175110 200 µM -0.00225899873032245 0.496756638630645 no 1662 0.499098790661591 2415 2831986 SGTC_1330 1469-0054 61.8 µM -0.00243357880649185 0.496818905883573 no 1663 0.499029143479687 2413 7102664 SGTC_1341 1486-1360 280 µM -0.00285643677800251 0.496969726414734 no 1664 0.498860448147606 2413 3976547 SGTC_80 0159-0065 512.242 µM -0.00311489500868397 0.497061910791105 no 1665 0.498757338691526 2412 1548079 SGTC_2352 9027995 87.8 µM -0.00334028078731743 0.497142299334091 no 1666 0.498667423243559 2404 2997347 SGTC_3356 9151811 4.48 µM -0.00377795063193764 0.497298403749263 no 1667 0.498492819344961 2413 1859254 YPR165W RHO1 SGTC_263 alizarin 107.927 µM -0.00498399427494343 0.497728567364655 no 1668 0.498011682190151 2417 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_900 1112-0045 141 µM -0.00519207398237388 0.497802784130154 no 1669 0.497928671471815 2413 56211 YIL048W NEO1 SGTC_1925 st057770 10.1 µM -0.00541918611089306 0.497883789365284 no 1670 0.49783806811679 2418 5989122 SGTC_1674 st016616 23.6 µM -0.00584574537558855 0.498035932655555 no 1671 0.497667898291608 2410 625830 SGTC_39 0986-0283 58.349 µM -0.00639516449021067 0.498231897476787 no 1672 0.497448715885203 2412 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_2199 6590217 200 µM -0.00715796978372398 0.498503972805175 no 1673 0.497144407596566 2429 703109 SGTC_3208 9114115 49.47 µM -0.0072137343028082 0.498523862771803 no 1674 0.497122161346526 2432 650895 SGTC_2968 9090663 33.37 µM -0.00788196842397921 0.498762207327083 no 1675 0.49685558210097 2449 25236811 SGTC_1102 cgs 12066b 26.1 µM -0.010651804973249 0.499750151450635 no 1676 0.495750624990086 2452 6438352 A 5-HT1B full agonist. SGTC_2141 5621638 7.665 µM -0.0113522882221008 0.5 no 1677 0.495471189523768 2441 2856238 SGTC_1400 3771-8998 51.5 µM -0.0114045479094167 0.499981359999777 no 1678 0.495450342274513 2428 670767 SGTC_2541 muurolladie-3-one 83.07 µM -0.0115325745175134 0.499935695432828 no 1679 0.49539927040636 2500 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_432 NS 1619 61.3 µM -0.012914876210106 0.499442655850484 no 1680 0.494847853058593 2508 4552 A K+/calcium channel activator. SGTC_1644 st010134 20.9 µM -0.0131123550694509 0.499372219112201 no 1681 0.494769077063048 2432 3818134 SGTC_3061 glucosamine 200 µM -0.013209194737538 0.499337678356831 no 1682 0.494730446970669 2421 91431 and experimental redox chemotherapeutic SGTC_2060 5238662 140 µM -0.0144227798713524 0.498904817535279 no 1683 0.494246342785102 2450 790130 SGTC_3338 9144300 39.5675 µM -0.014788794671129 0.498774267824628 no 1684 0.494100339581224 2437 4901274 SGTC_1633 st005664 67.9 µM -0.0148255267413158 0.498761166281823 no 1685 0.494085687211749 2434 2063822 SGTC_3008 9078912 71.4286 µM -0.0154143067543958 0.498551161252106 no 1686 0.493850824821769 2438 16648731 SGTC_1570 verbenone 133 µM -0.0162554174319256 0.49825115607128 no 1687 0.493515312286217 2440 29025 A natural terpanoid with antifungal properties. SGTC_1692 fluoroquinolonic acid 71 µM -0.0165057840135951 0.498161856149869 no 1688 0.4934154438709 2493 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_610 4215-0184 155 µM -0.0166462582293569 0.498111752312858 no 1689 0.493359410465496 2445 5605015 SGTC_3101 9120531 49.47 µM -0.0169174491901713 0.498015024983268 no 1690 0.493251236159166 2427 24824904 SGTC_869 0564-0080 44.1 µM -0.0172961613732711 0.497879947601816 no 1691 0.493100173963375 2465 6843321 SGTC_1271 0832-2808 169 µM -0.0174493942932078 0.497825293231888 no 1692 0.493039052097319 2442 3663794 SGTC_65 0798-0905 34.986 µM -0.018112236833074 0.497588874273468 no 1693 0.492774657986138 2452 3602145 SGTC_1302 1159-0335 255 µM -0.0182280944849951 0.497547550900764 no 1694 0.49272844509964 2446 649284 SGTC_1217 1183-1422 255 µM -0.0184672198034596 0.497462261282022 no 1695 0.492633063955757 2459 2849664 SGTC_2165 5727197 32.143 µM -0.0187645891961239 0.497356197718825 no 1696 0.492514451287066 2536 1361712 SGTC_732 3970-1727 52.7 µM -0.0188197046506946 0.497336539557611 no 1697 0.492492467284048 2442 1275699 SGTC_302 1094-0063 18.9 µM -0.0188636016333318 0.49732088272028 no 1698 0.492474958029931 2455 5440289 SGTC_2458 5808907 16.39 µM -0.0229690751454306 0.495856595608412 no 1699 0.490837470448653 2451 2731747 SGTC_3220 9131269 49.47 µM -0.0231618595858472 0.495787836969591 no 1700 0.490760581040397 2442 17722206 SGTC_522 1273-0010 11.6 µM -0.0232004615207656 0.495774069190361 no 1701 0.490745185233602 2591 5705015 SGTC_49 0717-0965 32.132 µM -0.0234526177900082 0.495684135174227 no 1702 0.490644616801544 2618 5889349 YGL099W LSG1 SGTC_2407 paclitaxel 400 µM -0.0235447087947589 0.495651290065104 no 1703 0.490607887948118 2628 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2981 9013952 38.96 µM -0.023656871492505 0.495611286240754 no 1704 0.490563153965815 2480 2996344 SGTC_1322 1348-1070 12 µM -0.0244299588406944 0.495335558979767 no 1705 0.490254825876783 2445 6758089 SGTC_3028 9087778 49.47 µM -0.0247412174850306 0.495224546927928 no 1706 0.490130689166876 2458 17217395 SGTC_1930 st074634 34.3 µM -0.0250688035362733 0.495107712019108 no 1707 0.490000041765082 2444 684253 YOR116C RPO31 SGTC_2792 7535235 81.82 µM -0.0260403941150823 0.494761192760692 no 1708 0.489612559759994 2489 1281891 SGTC_553 k007-0256 45.7 µM -0.0283861108816369 0.493924606106439 no 1709 0.48867710082475 2475 6287000 SGTC_3215 9129942 49.47 µM -0.0285050384007984 0.493882191958192 no 1710 0.488629674800364 2470 17682944 SGTC_563 tetrahydrosecaminediol 614 µM -0.0291574543498143 0.493649516467006 no 1711 0.488369506652165 2475 334274 A psychoactive constituent of the cannabis plant. SGTC_3291 9121177 71.43 µM -0.0292535308528956 0.493615252237647 no 1712 0.48833119401602 2483 17015612 SGTC_2245 6637752 200 µM -0.0303832824667609 0.493212347040875 no 1713 0.487880688679937 2466 681890 SGTC_383 2324-0395 7.37 µM -0.0311669902676181 0.492932856067736 no 1714 0.487568182534429 2502 3146421 SGTC_177 1327-0068 8.361 µM -0.032513122149123 0.492452797934881 no 1715 0.48703142580046 2462 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_1380 2291-0730 164 µM -0.035329860591292 0.491448327639917 no 1716 0.48590835643976 2495 2999191 SGTC_1806 st050005 60.3 µM -0.0362597069488106 0.491116748968549 no 1717 0.485537638996834 2480 5194765 SGTC_1797 st048695 56.8 µM -0.0363484273330071 0.491085112029879 no 1718 0.485502268001364 2456 592262 YIL048W NEO1 SGTC_2068 5226020 147 µM -0.0365113584619335 0.491027012313473 no 1719 0.485437311003039 2485 1810509 SGTC_38 0929-0051 58.268 µM -0.0367392383508223 0.490945752796447 no 1720 0.485346461034784 2501 1379719 SGTC_2445 5742597 35.57 µM -0.0385228027072246 0.490309766178362 no 1721 0.484635425522107 2493 1774255 SGTC_3052 9092717 49.47 µM -0.0397026390285462 0.489889071437941 no 1722 0.484165098848493 2530 25237534 SGTC_62 0180-0423 3.232 µM -0.0397105089965291 0.489886265277345 no 1723 0.484161961659559 2500 30102 YGL099W LSG1 SGTC_464 bw-b 70c 158 µM -0.0397201766068502 0.489882818139846 no 1724 0.484158107881549 2568 5353454 SGTC_1991 st073000 8.92 µM -0.0399273569575342 0.489808944931036 no 1725 0.484075520395198 2559 4301969 YIL048W NEO1 SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.0401657323378672 0.489723949107116 no 1726 0.483980498602605 2506 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_2517 totarol 10 µM -0.0406379961191215 0.489555558731599 no 1727 0.483792246320325 2525 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_206 4546-0025 72.014 µM -0.0410377188583082 0.489413035043762 no 1728 0.483632912938274 2494 6620745 YIL048W NEO1 SGTC_120 rhodamine 6G 52.259 µM -0.042787849744811 0.488789030890482 no 1729 0.482935324809605 2494 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_185 k048-0037 25.491 µM -0.0428154724796204 0.488779182299489 no 1730 0.482924315022277 2475 6827589 SGTC_2269 7935389 174.42 µM -0.0436621579139896 0.48847730900105 no 1731 0.482586852021462 2477 97605 SGTC_3073 9114972 49.47 µM -0.0445290632882591 0.488168233419861 no 1732 0.48224134289663 2486 41905075 SGTC_1019 4262-0212 3.4 µM -0.0447495806997782 0.488089614030967 no 1733 0.482153456785392 2489 4677213 SGTC_440 fluspirilene 35.1 µM -0.0457231842263239 0.487742508174151 no 1734 0.481765442395584 2713 3396 An atypical antipsychotic. SGTC_602 3130-1533 38.1 µM -0.046098347245852 0.487608758779217 no 1735 0.481615931658235 2552 720941 SGTC_1119 parthenolide 318.541 nM -0.0475886523138865 0.487077463923932 no 1736 0.481022037962849 2626 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_169 k015-0017 16.025 µM -0.0479727565375849 0.486940534164479 no 1737 0.480868977366975 2502 1840002 SGTC_1117 retinoic acid 1.10837 µM -0.049243622425638 0.486487492775098 no 1738 0.480362573873039 2503 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_1474 0330-0125 5.35 µM -0.0515657743707756 0.485659731812254 no 1739 0.479437345568133 2515 X1474 SGTC_1523 st012844 44.7 µM -0.0519661974876745 0.485517001982325 no 1740 0.479277813751163 2606 4274103 SGTC_512 prima-1 270 µM -0.0523569845942813 0.485377708673287 no 1741 0.479122124199351 2605 322968 A re-activator of the apoptotic function of mutant p53. SGTC_1922 5578187 25 µM -0.0527559765168086 0.485235492656348 no 1742 0.478963169136173 2519 1350412 SGTC_3022 9087993 49.47 µM -0.0550336625165671 0.484423674551716 no 1743 0.478055822805085 2499 17173644 SGTC_2039 Aminomethylbenzodioxan 200 µM -0.056308398797766 0.483969358064023 no 1744 0.477548064089515 2496 15053 SGTC_1405 3909-7894 12 µM -0.0564324277467831 0.483925155201657 no 1745 0.477498662250398 2552 7104060 SGTC_3095 9117207 49.47 µM -0.0570284575139177 0.483712738028287 no 1746 0.477261263102905 2494 17015229 SGTC_2235 salicylic acid 500 µM -0.0570816970315318 0.483693764388119 no 1747 0.477240058150494 2499 338 A COX inhibitor and kinase inhibitor. SGTC_2095 5432005 200 µM -0.0583150763306905 0.483254219834852 no 1748 0.476748829388058 2527 783734 SGTC_651 3253-0966 34.4 µM -0.059238929269461 0.482924995790313 no 1749 0.476380901499072 2525 781462 SGTC_4 0960-0234 25.671 µM -0.0594039541741206 0.482866188768091 no 1750 0.476315181824016 2525 6821112 SGTC_2715 st079500 56.4 µM -0.0595743143963003 0.482805480883662 no 1751 0.47624733808289 2501 28246688 SGTC_3132 9126706 49.47 µM -0.0610731168979177 0.482271399782223 no 1752 0.475650489390791 2663 850858 SGTC_644 1498-1197 63.3 µM -0.0614360445701664 0.482142079411951 no 1753 0.475505973573483 2569 6741615 SGTC_1017 4239-0030 168 µM -0.0618297510338889 0.482001793899787 no 1754 0.475349205453781 2542 1149593 SGTC_2933 9026794 32.47 µM -0.0629296269146476 0.481609897920099 no 1755 0.474911271363372 2555 17586027 SGTC_2626 ethyl orsellinate 100 µM -0.0632391965608295 0.481499598571729 no 1756 0.474788016442733 2536 75653 A natural product. SGTC_3038 9091290 49.47 µM -0.0649076598244609 0.480905151414753 no 1757 0.474123760899617 2543 25236843 SGTC_3352 9151559 45.5865 µM -0.0671391843303552 0.480110161013781 no 1758 0.473235449834779 2564 17159339 SGTC_218 alverine citrate 93.75 µM -0.0676904162815411 0.479913794273358 no 1759 0.473016039256523 2611 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1134 3477-0009 42.5 µM -0.0688739431043591 0.479492200075083 no 1760 0.472544979822309 2592 3973534 SGTC_1441 4106-0040 13 µM -0.0691658639963794 0.479388215949835 no 1761 0.472428797298274 2526 2904180 SGTC_3190 9110366 49.47 µM -0.0709245196315082 0.478761801277406 no 1762 0.471728914334408 2539 17123768 SGTC_653 0203-0016 55.2 µM -0.0715559705314773 0.478536897815059 no 1763 0.471477640315778 2595 295302 SGTC_1006 4099-6547 255 µM -0.0720554861462275 0.478358990496665 no 1764 0.471278875502395 2595 3146833 SGTC_1891 st059073 26.2 µM -0.0723669072986141 0.478248077020576 no 1765 0.471154959935921 2559 688754 SGTC_17 0960-0276 49.807 µM -0.0728384317109033 0.478080145549539 no 1766 0.470967344041076 2535 6821114 SGTC_693 4161-2696 114 µM -0.0735484864088155 0.4778272698552 no 1767 0.470684830972191 2629 805759 SGTC_2078 5212016 200 µM -0.0736208311095615 0.477801505837444 no 1768 0.47065604764446 2512 1899708 SGTC_926 2268-1401 59.4 µM -0.0740615552518733 0.477644553369083 no 1769 0.470480702839418 2534 2931578 SGTC_3094 9117742 49.47 µM -0.074608206098926 0.477449882673456 no 1770 0.470263222400477 2530 17149698 SGTC_3072 9116419 49.47 µM -0.074934682493828 0.477333622018331 no 1771 0.470133340740675 2586 17170162 SGTC_1379 2144-0755 36.5 µM -0.0760238944702423 0.476945759599859 no 1772 0.469700044084114 2555 5392327 SGTC_2321 7390090 138.78 µM -0.0761490935948308 0.476901178269861 no 1773 0.469650241226938 2603 649046 SGTC_964 1287-0107 19.4 µM -0.0761570958731024 0.476898328801227 no 1774 0.469647058023358 2598 51516812 YPR165W RHO1 SGTC_875 0709-0210 25.7 µM -0.0782179396410995 0.476164538810796 no 1775 0.468827345982845 2538 6251364 SGTC_1025 k007-0731 70 µM -0.0783817805952567 0.476106204562479 no 1776 0.468762182958475 2545 6256118 SGTC_2850 9015429 58.44 µM -0.0794195460659659 0.475736728494783 no 1777 0.468349461116631 2593 6457570 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.0796898739353571 0.475640486964271 no 1778 0.468241956634472 2642 688751 SGTC_1781 st038725 66.3 µM -0.0800208076059544 0.47552267062577 no 1779 0.468110353479983 2554 4270275 YIL048W NEO1 SGTC_886 0866-0150 153 µM -0.0815976069167017 0.474961340810636 no 1780 0.467483352177094 2581 271463 SGTC_2851 9015922 71.43 µM -0.0818054965197609 0.474887337211909 no 1781 0.467400692568205 2625 2996893 SGTC_2497 7-hydroxyflavone 100 µM -0.0822635005680591 0.474724302067142 no 1782 0.467218589169266 2691 5281894 SGTC_1832 st054113 55 µM -0.0828979738239553 0.47449845639153 no 1783 0.466966332575818 2562 1251267 SGTC_220 paclitaxel 373.376 µM -0.0845609168305647 0.47390655800472 no 1784 0.466305235791925 2644 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_835 0312-0010 67.2 µM -0.0846243241724399 0.473883990291162 no 1785 0.466280030268146 2546 1626196 SGTC_2705 st078069 42.8 µM -0.0846782138481359 0.473864810137075 no 1786 0.46625860828891 2622 1530061 SGTC_3200 9114385 49.47 µM -0.0850770563983988 0.473722857901982 no 1787 0.466100065252131 2623 17018030 YLR208W SEC13 SGTC_1983 st071813 46.9 µM -0.0859936390459154 0.473396649225058 no 1788 0.465735736900941 2623 11838595 SGTC_2844 9010103 25.97 µM -0.0863055884776093 0.473285631530957 no 1789 0.465611748046062 2717 2480525 SGTC_2362 9071156 126 µM -0.0891243554615972 0.472282573648716 no 1790 0.46449154077712 2649 653133 SGTC_1520 flindersine 88 µM -0.0893991751616506 0.472184788393536 no 1791 0.464382339486863 2805 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_2522 biochanin a 4.94 µM -0.0905215092500416 0.471785461398461 no 1792 0.463936401104473 2616 5280373 A possible chelator. SGTC_685 1278-0033 54.9 µM -0.0905219579236965 0.471785301765809 no 1793 0.46393622284144 2574 3590572 SGTC_659 k018-0002 107 µM -0.0917984715877321 0.47133115211403 no 1794 0.463429079216181 2603 6797879 YHR007C ERG11 SGTC_2545 solidagenone 89.61 µM -0.0922093741186958 0.471184971811656 no 1795 0.463265845154123 2547 6708572 An anti ulcer agent SGTC_1396 3511-0007 98.6 µM -0.0927721264191735 0.470984776618796 no 1796 0.46304229769156 2651 X1396 SGTC_2519 cryptotanshinone 88.04 µM -0.0937839193675198 0.470624856833716 no 1797 0.462640402932022 2597 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_156 3474-0145 5.642 µM -0.0962770380319534 0.469738095856196 no 1798 0.461650273676589 2551 2265471 SGTC_1014 4130-3005 69.3 µM -0.0966370086550719 0.469610072568008 no 1799 0.461507332683631 2592 743608 SGTC_2425 5628681 7.85 µM -0.097192553581491 0.469412499592607 no 1800 0.461286740715246 2642 5714958 SGTC_1596 piperlongumine 63 µM -0.0976000267437169 0.469267591371991 no 1801 0.461124951635149 2680 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_1490 4089-0339 670 nM -0.0987058242167524 0.46887436114732 no 1802 0.46068592219764 2582 742542 SGTC_1583 clindamycin 39.6 µM -0.0996101422152652 0.468552801148966 no 1803 0.460326920776517 2596 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_2729 fluphenazine 10.66 µM -0.0997900747552901 0.468488822658489 no 1804 0.46025549395769 2597 3372 An atypical antipsychotic. SGTC_412 gemfibrozil 100 µM -0.100328033278393 0.468297545973744 no 1805 0.460041951215488 2566 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_1936 st074407 74.3 µM -0.100658188113714 0.468180159648163 no 1806 0.45991090189141 2583 809813 SGTC_3014 9081533 49.47 µM -0.100697029592848 0.468166349768549 no 1807 0.459895484715578 2635 21367265 SGTC_374 0880-0231 82.3 µM -0.10087510879933 0.468103035152347 no 1808 0.459824801299268 2638 6833587 SGTC_483 fpl-64176 144 µM -0.101407508498746 0.46791374957952 no 1809 0.459613488141151 2592 3423 SGTC_3188 9110789 49.47 µM -0.102086676382884 0.467672293633661 no 1810 0.459343938232931 2671 849217 SGTC_1299 1079-1439 3.74 µM -0.102450442444076 0.467542973384053 no 1811 0.459199573494318 2605 323161 SGTC_1459 k035-0031 35.7 µM -0.104335285488081 0.466872959512841 no 1812 0.458451638469618 2573 3877128 YMR208W ERG12 SGTC_325 2810-4341 181 µM -0.105388468979825 0.466498620260961 no 1813 0.458033782765462 2674 774970 SGTC_2914 7968218 45.32 µM -0.106199288674657 0.466210445982113 no 1814 0.457712117655807 2671 2977111 SGTC_2308 7584454 197.62 µM -0.106685050827772 0.466037809221163 no 1815 0.457519421313001 2644 893577 SGTC_933 2914-0560 114 µM -0.10709002819748 0.465893887738593 no 1816 0.457358779009605 2625 463887 SGTC_1224 0823-0416 294 µM -0.107470652531307 0.465758624941255 no 1817 0.457207803171212 2699 3598164 SGTC_1283 0922-0125 16.4 µM -0.108011005584952 0.465566606008777 no 1818 0.456993481046137 2676 3360884 SGTC_2018 5133068 143 µM -0.108818013802931 0.465279843895865 no 1819 0.456673417858198 2596 785362 SGTC_1514 1189-1591 158 µM -0.109626650352648 0.46499252125582 no 1820 0.456352737057393 2782 767698 YMR146C TIF34 SGTC_2514 salinomycin 42.74 µM -0.10969097649893 0.464969665838189 no 1821 0.456327228470992 2708 23682228 A polyether potassium ionophore. SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.110105177313241 0.464822500884534 no 1822 0.45616298111151 2589 66535 A nucleotide analog. SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.112803413871677 0.463863939983769 no 1823 0.455093205871511 2701 6708739 YPR165W RHO1 SGTC_125 0133-0007 11.75 µM -0.11301198202309 0.463789853853615 no 1824 0.455010527896387 2702 26541 SGTC_585 0kpi-0023 191 µM -0.114714198412808 0.463185251540987 no 1825 0.454335829759983 2680 64601 SGTC_947 3447-0010 211 µM -0.116192876896962 0.462660115577397 no 1826 0.453749840964542 2575 748350 SGTC_499 genistein 192 µM -0.116427585826657 0.462576767312367 no 1827 0.45365683686447 2641 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_1888 azatryptophan 97.5 µM -0.117157258264734 0.462317661427799 no 1828 0.453367718280685 2728 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_365 0121-0052 13.6 µM -0.118537077058389 0.461827733079162 no 1829 0.452821059464348 2701 3101739 SGTC_1939 st074455 53.6 µM -0.118930305196682 0.461688121250791 no 1830 0.45266528603684 2780 1644229 SGTC_1621 st003705 32.4 µM -0.119044240285393 0.461647670586301 no 1831 0.452620153141394 2730 24207032 SGTC_1953 st076800 12.1 µM -0.119129573527573 0.461617374767994 no 1832 0.452586350643281 2655 297591 SGTC_745 0469-0705 296 µM -0.119554224230181 0.461466614556774 no 1833 0.452418141657424 2701 3486736 SGTC_2551 apiole 73.87 µM -0.121354366787692 0.460827586644561 no 1834 0.451705179848937 2601 10659 A possible DNA adduct former. SGTC_2667 digitoxin 100 µM -0.123148227766134 0.46019088922497 no 1835 0.450994860829704 2659 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_1259 0671-0132 43 µM -0.123288430032242 0.460141131330595 no 1836 0.450939351216004 2658 X1259 SGTC_118 0083-0097 135.343 µM -0.124055928425518 0.459868756629597 no 1837 0.450635496273511 2657 5207356 SGTC_2109 5483026 200 µM -0.124913395309567 0.459564475618599 no 1838 0.450296056755743 2667 759335 SGTC_1324 1418-0026 34.4 µM -0.126242274703821 0.459092955849691 no 1839 0.449770074328759 2727 1372513 SGTC_2868 9035608 32.47 µM -0.126480266103114 0.459008516583092 no 1840 0.449675884479849 2589 6462614 SGTC_1705 st027868 56.3335 µM -0.126809159955354 0.458891828202066 no 1841 0.44954572283736 2707 292948 SGTC_608 k048-0125 159 µM -0.127702532487387 0.458574886110772 no 1842 0.449192192934746 2670 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_2661 dactinomycin 12.96 µM -0.127714946672066 0.458570482111093 no 1843 0.449187280614182 2639 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_1763 st044482 94.5 µM -0.12874622278918 0.458204649096839 no 1844 0.448779229623076 2757 88505 SGTC_1802 st050112 57.9 µM -0.130345963356204 0.457637230200188 no 1845 0.448146358365876 2610 4662563 SGTC_730 1436-0052 41.2 µM -0.131998604410924 0.457051138477807 no 1846 0.447492697804522 2629 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.132748495065894 0.456785228395386 no 1847 0.447196144355719 2773 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_305 1682-2595 20.8 µM -0.132932731094957 0.456719901536794 no 1848 0.4471232904712 2693 226033 SGTC_705 1124-0212 310 µM -0.133408558934667 0.456551186761684 no 1849 0.446935138432081 2637 9554485 SGTC_2211 7117706 200 µM -0.133997570580095 0.456342351137934 no 1850 0.446702247753502 2650 822771 SGTC_2130 NSC 7 2.4545 µM -0.135099313472659 0.455951757723652 no 1851 0.446266676485989 2724 21448 SGTC_620 0109-0052 432 µM -0.136450348274399 0.455472842684544 no 1852 0.445732636835847 2680 493037 SGTC_3150 9097574 49.47 µM -0.136676169164782 0.455392799950128 no 1853 0.445643383493651 2707 17217476 SGTC_134 0269-0018 6.916 µM -0.137330888620207 0.455160743378848 no 1854 0.445384628072062 2742 4378915 SGTC_2436 5633522 8.09 µM -0.137923113208309 0.454950850455305 no 1855 0.445150591641009 2693 5724242 SGTC_1312 1218-2183 165 µM -0.139381211593279 0.454434133106111 no 1856 0.444574459204628 2639 6744073 SGTC_554 4483-2211 187 µM -0.142211006864845 0.453431537948555 no 1857 0.443456668966837 2750 747107 SGTC_3320 9137005 35.139 µM -0.142868700449227 0.453198559680025 no 1858 0.443196939185029 2721 4908713 SGTC_2877 9040724 71.43 µM -0.143074448376972 0.453125679810026 no 1859 0.443115692274412 2816 6463895 SGTC_788 1182-0090 188 µM -0.144556394758056 0.452600792711065 no 1860 0.442530563725667 2869 5715185 SGTC_1443 4112-3303 14 µM -0.145103191380388 0.452407144970725 no 1861 0.442314699300837 2673 704433 SGTC_2221 6807166 181.081 µM -0.146722561834863 0.451833712346163 no 1862 0.441675504781331 2676 674925 SGTC_2751 anetholtrithion 17.25 µM -0.147015090151738 0.45173013630182 no 1863 0.441560054761323 2787 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_2267 7931562 200 µM -0.149485940227781 0.450855409599591 no 1864 0.440585101394326 2626 934880 SGTC_446 go6976 132 µM -0.150434404450331 0.450519698841525 no 1865 0.440210949641198 2774 3501 A protein kinase C inhibitor. SGTC_1074 carmofur 3.8 µM -0.154223594586431 0.44917886317438 no 1866 0.438716719479456 2667 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_912 3474-0017 2.18 µM -0.154293632556944 0.449154085084135 no 1867 0.438689108841337 2831 3360550 SGTC_3189 9110682 49.47 µM -0.154949624792227 0.448922017255979 no 1868 0.438430515561916 2770 17122418 SGTC_2537 larixol 68.93 µM -0.156078790279713 0.448522597731257 no 1869 0.437985458184082 2657 6708759 SGTC_410 α-linolenic acid 100 µM -0.156394724811766 0.448410851584303 no 1870 0.43786094750156 2801 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.15684050580107 0.448253185667321 no 1871 0.437685274434156 2681 368090 SGTC_970 1315-0089 19.5 µM -0.157545415465627 0.448003886592843 no 1872 0.437407509195298 2680 6811083 YLR033W RSC58 SGTC_3097 9117246 49.47 µM -0.1577140827867 0.447944238576178 no 1873 0.437341051461924 2670 16423892 SGTC_1479 0549-0158 134 µM -0.159023488372988 0.447481216602033 no 1874 0.436825184130222 2730 5440202 SGTC_1125 tnp00248 1.32998 µM -0.159572366309279 0.447287147839959 no 1875 0.436608974246835 2853 24207736 SGTC_359 0081-0058 15.9 µM -0.160471180936059 0.446969377968304 no 1876 0.436254960847434 3059 3494159 SGTC_1040 k898-0338 155 µM -0.161239383661213 0.446697812031194 no 1877 0.435952431619134 2781 20969351 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.161456712327742 0.446620989102884 no 1878 0.435866851271885 2663 1241132 A phosphatase inhibitor. SGTC_893 0958-0369 48.9 µM -0.163776311157191 0.445801165689818 no 1879 0.434953620404928 2841 6819948 SGTC_2837 9008476 45.46 µM -0.16447196966529 0.445555341824305 no 1880 0.434679805603385 2901 2992805 SGTC_2884 9058502 51.95 µM -0.165440800545352 0.445213022315527 no 1881 0.434298520960439 2793 6471554 SGTC_1643 st009866 20.2 µM -0.165622287049895 0.445148901756646 no 1882 0.434227103497726 2759 3156273 YOR207C RET1 SGTC_2002 4023503 131 µM -0.165679418970612 0.445128716912528 no 1883 0.434204621736767 2721 4736863 YCR052W RSC6 SGTC_2441 5730946 39.09 µM -0.166699837716711 0.444768224541308 no 1884 0.433803116616662 2827 1774275 SGTC_2416 tofa 880 nM -0.166755531470936 0.444748550427163 no 1885 0.433781204704693 2732 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1990 st072050 59.8 µM -0.166807124298248 0.444730325108653 no 1886 0.433760906425406 2659 17233948 SGTC_280 3448-3607 3.04 µM -0.167378148764833 0.444528616842332 no 1887 0.433536258694162 2742 626179 SGTC_1525 8-methoxypsoralen 92.5 µM -0.168090654897282 0.444276951845806 no 1888 0.433255980530828 2927 4114 Related to psoralen; DNA damaging agent. SGTC_3024 9090631 49.47 µM -0.169101430476616 0.443919973366358 no 1889 0.43285842988848 2717 25236383 SGTC_624 k048-0052 28 µM -0.170028112787249 0.443592734314134 no 1890 0.432494013868878 2759 6835531 SGTC_409 arachidonic acid 100 µM -0.170751103173376 0.443337451629211 no 1891 0.432209739158339 2706 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.171896039550017 0.442933231009755 no 1892 0.431759630111859 2761 688788 SGTC_2006 4011487 200 µM -0.17235066609097 0.442772741228732 no 1893 0.431580927233911 2840 45595294 SGTC_257 daunorubicin 18.5 µM -0.172626000263654 0.442675548824965 no 1894 0.431472706726108 2833 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1354 1498-1681 81 µM -0.173917285212153 0.442219773983268 no 1895 0.430965234007 2789 5754243 SGTC_419 nsc-638432 893 µM -0.176072513240758 0.44145923047635 no 1896 0.430118487401799 2796 368090 SGTC_2379 9035213 200 µM -0.176710467898904 0.441234148338441 no 1897 0.429867909042426 2809 646551 SGTC_809 3998-0021 90 µM -0.177585424573378 0.440925478409215 no 1898 0.429524286048424 2785 715485 SGTC_2528 xanthyletin 44.79 µM -0.17811178517896 0.440739804557833 no 1899 0.429317593393256 2748 65188 An natural product with antifungal activity of unknown mechanism. SGTC_1167 k781-0610 148 µM -0.178437958155252 0.440624753483802 no 1900 0.429189520658817 2783 4525169 SGTC_665 3914-0008 307 µM -0.178968030269277 0.440437791711977 no 1901 0.428981402261239 2722 1069549 SGTC_1153 4055-0057 267 µM -0.179234914575292 0.440343663953003 no 1902 0.42887662486657 2722 882706 SGTC_2617 dihydrotanshinone i 20.83 µM -0.179241285451234 0.440341417041992 no 1903 0.42887412375493 2733 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_1815 st051655 58.2 µM -0.180065368552547 0.440050791692266 no 1904 0.428550625035194 2762 5984156 SGTC_2558 carylophyllene oxide 100 µM -0.180139791476175 0.44002454691222 no 1905 0.428521412234166 2719 6708694 An oxygenated terpenoid and antifungal agent. SGTC_3273 9137859 49.47 µM -0.183007093214985 0.439013612569351 no 1906 0.427396226515942 2729 2377234 SGTC_2466 5983409 37.09 µM -0.18394392894347 0.438683395077485 no 1907 0.427028721212277 2778 2879657 SGTC_1837 st055472 66.5 µM -0.184068414616051 0.438639519357732 no 1908 0.426979892282517 2896 676091 SGTC_882 0843-0131 351 µM -0.185327710135703 0.438195715608798 no 1909 0.426486002466382 2723 5425421 SGTC_3186 9110464 49.47 µM -0.186708046933725 0.43770934352059 no 1910 0.425944773255297 2862 17018021 SGTC_511 blebbistatin 171 µM -0.186878918195603 0.437649142272208 no 1911 0.425877784419105 2875 3476986 A myosin inhibitor. SGTC_1938 st074717 56.4 µM -0.187160290211711 0.437550012617957 no 1912 0.42576747922764 2692 17250979 SGTC_940 3232-1287 54.8 µM -0.187324557492811 0.437492141727931 no 1913 0.425703084840888 2725 1585493 YIL048W NEO1 SGTC_1349 flufenamic acid 69 µM -0.189338212313147 0.436782845968923 no 1914 0.42491387391599 2730 3371 A non-steroidal anti-inflammatory. SGTC_1158 4092-0494 91.8 µM -0.190427644592162 0.436399185659008 no 1915 0.424487018372451 2869 1148199 SGTC_2712 st079126 47.7 µM -0.190916710791594 0.436226972920672 no 1916 0.424295423831161 2726 3152970 SGTC_2050 5263056 171 µM -0.191432502114087 0.436045362679988 no 1917 0.424093378949139 2870 763468 YGL055W OLE1 SGTC_731 3966-0296 387 µM -0.192412961700858 0.435700179845694 no 1918 0.423709370064833 2758 660956 SGTC_2855 9016525 58.44 µM -0.194478949686752 0.434972984063969 no 1919 0.422900438386716 2725 43811474 SGTC_1188 1403-0014 4.57 µM -0.194608639741647 0.434927342482456 no 1920 0.422849669422222 2780 9614867 SGTC_538 2922-0838 53.3 µM -0.194812572619714 0.434855574515243 no 1921 0.422769839670333 2825 777039 SGTC_2384 9036245 200 µM -0.195692001174986 0.434546111025348 no 1922 0.422425622751873 2812 6462766 SGTC_1794 st048918 76.9 µM -0.195876745585231 0.434481106116351 no 1923 0.422353319507018 2709 672303 SGTC_2805 7950783 58.44 µM -0.196631201451508 0.434215658655865 no 1924 0.422058076014152 2878 1178958 YDL195W SEC31 SGTC_1453 4237-0541 195 µM -0.197889969933387 0.433772840120403 no 1925 0.42156557591563 2840 739892 SGTC_1552 6-methylflavone 10.6 µM -0.198954227115873 0.433398512968038 no 1926 0.421149275101253 2766 689013 SGTC_1779 st039427 55 µM -0.199570316097877 0.433181845599823 no 1927 0.42090832252633 2784 1124498 SGTC_2403 6032726 181.2 µM -0.199996745553096 0.43303188981865 no 1928 0.420741563188996 2842 2881040 SGTC_1043 0916-0009 19.3 µM -0.20001935898059 0.433023937977099 no 1929 0.42073272038763 2928 3101130 SGTC_808 0711-0032 135 µM -0.201573172564028 0.432477616247536 no 1930 0.420125209944968 2725 4252555 SGTC_678 1218-2179 85.9 µM -0.201861065178047 0.432376407183538 no 1931 0.420012670463318 2754 6820081 YOR116C RPO31 SGTC_1361 1608-0041 5.61 µM -0.201955732114383 0.432343127854503 no 1932 0.419975665843536 2773 X1361 SGTC_3287 9117173 37.0625 µM -0.202415160275136 0.432181626746021 no 1933 0.419796088756785 2801 2789709 SGTC_13 0199-0087 65 µM -0.202581111043117 0.432123293461224 no 1934 0.41973122753849 2754 4589825 SGTC_1409 3909-8004 61.9 µM -0.202668206052896 0.432092679322902 no 1935 0.419697187661855 2804 2119279 SGTC_225 nsc-122657 1.016 µM -0.203068321802469 0.431952042765654 no 1936 0.419540815694791 2887 275685 SGTC_2370 9071495 200 µM -0.203331176579264 0.431859656716152 no 1937 0.419438094538646 2841 21791103 SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.204016535248909 0.431618789987973 no 1938 0.419170288700131 2779 77254 SGTC_231 b-estradiol 524 µM -0.20440641210393 0.431481780571462 no 1939 0.419017959917168 2784 450 A steroid. SGTC_2720 fluspirilene 36.88 µM -0.20459829629602 0.431414352199714 no 1940 0.418942993302045 2861 3396 An atypical antipsychotic. SGTC_2155 5570423 76 µM -0.20493347645152 0.431296574223105 no 1941 0.418812049911955 2782 797402 SGTC_1745 st081495 74 µM -0.205116977481595 0.43123209691857 no 1942 0.418740366162569 2775 13842402 YBL026W LSM2 SGTC_1998 st075797 76.8 µM -0.20522852240827 0.431192903940246 no 1943 0.418696793019443 2723 24208315 SGTC_761 k216-0224 480 µM -0.205613661626769 0.431057584725992 no 1944 0.418546352554558 2916 1340404 SGTC_284 0988-0104 32.6 µM -0.205739415514025 0.431013402669986 no 1945 0.418497234004356 2868 4666532 SGTC_1261 0712-0010 12.7 µM -0.207246322645263 0.430484036999271 no 1946 0.417908746145676 2902 2840123 SGTC_2842 9000675 19.48 µM -0.207436228061036 0.430417333430808 no 1947 0.41783459597283 2836 2989072 SGTC_2263 7948595 193.29 µM -0.207758368503697 0.43030418734427 no 1948 0.41770882019869 2768 2971371 SGTC_110 0850-0284 111.64 µM -0.208565856928884 0.430020596601841 no 1949 0.417393583295721 2730 3906265 SGTC_367 0335-0881 7.1 µM -0.208585170399226 0.430013814133185 no 1950 0.417386044123492 2924 23828853 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.209037967013967 0.429854807780724 no 1951 0.417209299943983 2904 5024745 SGTC_2249 haloperidol 116.36 µM -0.209924041171426 0.429543682429822 no 1952 0.416863479069829 2759 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_413 propylparaben 100 µM -0.211304911846539 0.429058907518626 no 1953 0.416324675179316 2764 7175 A pharmaceutical preservative. SGTC_1235 benzylparaben 21.5 µM -0.211443395298614 0.42901029676149 no 1954 0.4162706487808 2866 7180 SGTC_471 1-acyl-paf 4 µM -0.213262992788955 0.428371678051491 no 1955 0.41556091851395 2781 16759367 SGTC_2469 5655019 90.81 µM -0.213503259058703 0.428287366494541 no 1956 0.415467223680268 2923 2788239 SGTC_1185 1319-0113 81.3 µM -0.21475794734095 0.427847138554613 no 1957 0.414978020508864 2891 4672763 SGTC_378 3970-0959 8.33 µM -0.215766261012108 0.427493420238281 no 1958 0.414584974324835 2912 6615653 SGTC_3144 9087057 49.47 µM -0.216203391285067 0.427340092214417 no 1959 0.41441460509964 2763 17249618 SGTC_333 3486-0131 40.1 µM -0.216630036229555 0.427190452612215 no 1960 0.414248338001839 2938 6744690 SGTC_2666 tannic acid 100 µM -0.216760774184368 0.427144600243394 no 1961 0.414197391403553 2864 16134267 A thiamine antagonist. SGTC_122 0236-0016 402.397 µM -0.217446087296303 0.426904263589838 no 1962 0.413930358915295 2827 6808838 SGTC_903 1134-0042 114 µM -0.217513873719114 0.426880492627131 no 1963 0.413903948073048 2791 701009 SGTC_698 k064-0052 127 µM -0.217520312660068 0.426878234669226 no 1964 0.413901439362984 2761 5088751 SGTC_3274 9138298 49.47 µM -0.217811127630748 0.426776256428425 no 1965 0.413788137058677 2768 17015756 SGTC_178 4092-0806 87.505 µM -0.2182589735592 0.426619222712075 no 1966 0.413613669104559 2836 2169044 SGTC_2288 7946289 167.31 µM -0.219069919261821 0.426334900479607 no 1967 0.413297791291471 2974 1246052 SGTC_2102 5377816 72.7585 µM -0.219488137369429 0.426188285755828 no 1968 0.413134909798613 2978 1379702 SGTC_3044 9093193 49.47 µM -0.220050427313105 0.425991179849222 no 1969 0.412915940875447 2900 25236277 SGTC_1889 st059080 5.18 µM -0.220527208417406 0.425824062814073 no 1970 0.412730292327178 2899 176925 Isolated from Daphnopsis sellowiana. SGTC_448 monastrol 171 µM -0.221908557521444 0.425339960034814 no 1971 0.412192534336486 2829 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_1088 bifonazole 369 nM -0.222264846525151 0.425215114463882 no 1972 0.412053858039328 2776 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_1632 st005650 90 µM -0.222426872361319 0.425158342224816 no 1973 0.411990797296725 2928 2759605 SGTC_478 N-arachidonylglycine 10 µM -0.222978506348661 0.424965066814103 no 1974 0.411776117420498 2794 5283389 SGTC_874 0599-0792 117 µM -0.223324733162542 0.424843768904371 no 1975 0.411641389514816 2966 765305 SGTC_2325 6158266 200 µM -0.224686393290688 0.424366790847745 no 1976 0.411111625281909 2885 3623240 SGTC_211 3455-0679 143.504 µM -0.224902899325408 0.42429096079652 no 1977 0.411027406869715 2869 748649 SGTC_2037 5169046 200 µM -0.226162815307106 0.423849737827575 no 1978 0.410537395210232 2907 5718022 SGTC_1882 5615643 20 µM -0.226824845756336 0.423617932775863 no 1979 0.410279971534169 2775 2253075 SGTC_2231 micatex 6.853 µM -0.229171876135445 0.422796350976366 no 1980 0.409367665258319 2836 20737 An antifungal of unknown mechanism. SGTC_2944 9067346 25.62 µM -0.229504581220719 0.422679914104237 no 1981 0.409238380174431 2976 6473075 SGTC_2076 5212012 200 µM -0.229970558530624 0.422516847280458 no 1982 0.409057323749168 2757 604802 SGTC_1661 st013063 9.66 µM -0.231008694521969 0.422153603686404 no 1983 0.40865402372641 2827 721395 SGTC_3228 9131799 49.47 µM -0.231308998918521 0.422048539565256 no 1984 0.40853737805708 2871 17015818 SGTC_1267 0828-0272 9.49 µM -0.233553095673427 0.421263598786044 no 1985 0.407665972443839 2960 745334 SGTC_859 0439-0102 54.6 µM -0.234688470218273 0.420866586141021 no 1986 0.407225268634141 2907 610143 SGTC_1914 st062367 72.6 µM -0.235681330156647 0.420519473293829 no 1987 0.406839979109207 2831 978205 SGTC_1146 3579-1023 7 µM -0.235947750016565 0.420426340996883 no 1988 0.406736607463968 2919 X1146 SGTC_1081 sertraline 6 µM -0.237373876316029 0.419927886392864 no 1989 0.406183377157257 2936 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_1868 st057644 42.7 µM -0.24002962552837 0.419000001175027 no 1990 0.405153644996002 2802 688665 SGTC_7 0192-1582 4.227 µM -0.242012575777285 0.418307476795253 no 1991 0.404385209390972 2876 252616 SGTC_1710 st031758 61.5 µM -0.242786103521814 0.418037398941916 no 1992 0.404085550660638 2992 5394341 SGTC_1960 st011366 51.8 µM -0.243173398715935 0.417902189014658 no 1993 0.403935536595249 2811 3972846 SGTC_737 1950-0117 57.9 µM -0.243844678306661 0.417667859333563 no 1994 0.40367555811714 2961 5393513 SGTC_1759 st043059 70 µM -0.244786245303505 0.417339227239813 no 1995 0.403310972317075 2836 669426 SGTC_167 3672-0051 66.205 µM -0.246412725998521 0.41677167805482 no 1996 0.40268137799022 2799 3237971 SGTC_3299 9121982 43.1275 µM -0.246845365781356 0.41662074054884 no 1997 0.402513949893164 2874 17594604 YPL160W CDC60 SGTC_605 1315-0399 119 µM -0.249094853347548 0.415836147600122 no 1998 0.401643705222986 2976 24020461 SGTC_1796 st049173 110.4 µM -0.249215706765849 0.415794004913844 no 1999 0.401596965206507 2904 94134 SGTC_1854 st056233 32.9 µM -0.250492395999466 0.415348871004997 no 2000 0.401103292209099 2894 5393174 SGTC_561 1550-0330 72.9 µM -0.250575070643646 0.415320049179538 no 2001 0.401071328829953 2855 6812934 SGTC_2659 sanguinarine 24.21 µM -0.250792877461972 0.415244120098973 no 2002 0.4009871242972 2841 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_735 3076-0345 636 µM -0.25164445810145 0.41494728314576 no 2003 0.400657945773957 3008 2888990 SGTC_2825 7998094 58.44 µM -0.251946628695734 0.414841966674568 no 2004 0.400541158663922 2912 2987815 SGTC_2064 5220758 200 µM -0.252124042232311 0.414780135025614 no 2005 0.400472593545146 3017 788518 SGTC_2902 5787006 60.46 µM -0.254723264259751 0.413874504552888 no 2006 0.399468423264224 2850 591003 SGTC_2611 pyromycin 23.93 µM -0.255436190762009 0.413626183896269 no 2007 0.399193110728465 2893 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_822 1487-0950 154 µM -0.258259282051274 0.41264320821803 no 2008 0.398103404370915 2997 1958375 SGTC_2305 7443522 69.23 µM -0.258666896999118 0.412501325356618 no 2009 0.397946131417984 2859 5415886 SGTC_2892 9047358 58.44 µM -0.261731647289604 0.411434912574134 no 2010 0.396764169894874 2920 6466771 SGTC_1406 3909-7906 11.9 µM -0.262359994453453 0.411216352958585 no 2011 0.396521956225534 2907 X1406 SGTC_3121 9125696 49.47 µM -0.262403434789549 0.411201244011895 no 2012 0.396505212429607 2873 1235365 SGTC_205 1486-1330 71.903 µM -0.263803297878607 0.410714429441455 no 2013 0.395965746615182 2859 4118834 SGTC_2756 carbadox 75.1 µM -0.26601089165621 0.40994699917537 no 2014 0.395115410410253 2914 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_913 3487-1245 167 µM -0.266020567977473 0.40994363613323 no 2015 0.395111684314104 2830 4016153 SGTC_2602 kawain 100 µM -0.268327796511897 0.409141939753 no 2016 0.39422350597641 2854 5369129 SGTC_3103 9120822 49.47 µM -0.26855932388663 0.409061511485173 no 2017 0.394134408714085 3115 17141819 SGTC_1131 3454-3128 32.3 µM -0.269297528976001 0.408805098460851 no 2018 0.393850366780329 3030 710982 SGTC_2224 6650123 117.647 µM -0.269299968353377 0.40880425121606 no 2019 0.393849428265487 2880 2908370 SGTC_1743 st037606 46.3785 µM -0.271085658106467 0.408184159857501 no 2020 0.393162575948345 2897 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_1634 st006576 41 µM -0.271413666162047 0.40807028205845 no 2021 0.393036446160279 3071 3915356 SGTC_1681 tripelennamine 100 µM -0.271806171919541 0.407934022160432 no 2022 0.392885529661947 2864 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_1515 3460-0031 42.1 µM -0.27243917045667 0.407714297724425 no 2023 0.392642178821878 2909 2876596 SGTC_2988 9073640 71.4286 µM -0.274268464531322 0.407079482368406 no 2024 0.391939158637711 3090 9102229 SGTC_3313 9133968 57.047 µM -0.274360620732096 0.40704750807462 no 2025 0.391903751189333 2848 1494643 SGTC_356 1634-0012 32.5 µM -0.274837570859383 0.406882036509639 no 2026 0.39172051590078 2999 735457 SGTC_27 0485-0001 32.618 µM -0.275582034799015 0.40662378778138 no 2027 0.391434554842146 2866 2054479 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.27738752138429 0.4059976474404 no 2028 0.390741281166306 3001 7104 SGTC_112 phenothiazine 287.218 µM -0.277527702412153 0.405949042882405 no 2029 0.390687468722048 3031 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_1440 4100-1550 40 µM -0.277841583115003 0.405840217201947 no 2030 0.390566984347938 2919 742806 SGTC_3154 9100113 49.47 µM -0.277922549148233 0.405812146622453 no 2031 0.390535906913686 2913 25237525 SGTC_1813 st051246 8.6015 µM -0.2790852318999 0.405409102933832 no 2032 0.390089708138431 2986 5291959 SGTC_3157 9099274 49.47 µM -0.279235910094194 0.405356877706037 no 2033 0.390031893468254 3019 17217662 SGTC_1069 diphenylcyclopropenone 8.49 µM -0.280106419169072 0.405055191319503 no 2034 0.389697929989622 2926 65057 A dermal irritant. YDR527W RBA50 SGTC_2297 7971671 152.32 µM -0.280929907573334 0.404769852487742 no 2035 0.38938208053544 3065 909016 SGTC_1404 3909-7820 48.3 µM -0.281413045034393 0.404602468855272 no 2036 0.38919680687644 2998 23741373 SGTC_1175 0741-0056 27.6 µM -0.283031908671664 0.404041738750203 no 2037 0.388576188522125 3102 765927 SGTC_3169 9102970 49.47 µM -0.28498795857343 0.403364479596749 no 2038 0.387826683617447 2919 17027839 SGTC_3051 9093778 49.47 µM -0.286104203586556 0.402978122665725 no 2039 0.387399156037173 2934 17217378 SGTC_2400 5203494 178.7 µM -0.2865541202805 0.402822423368629 no 2040 0.387226874203167 2863 6777674 SGTC_2629 bisabolol 100 µM -0.288999029642554 0.401976601914945 no 2041 0.386291060061379 3079 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_328 k915-0120 63.5 µM -0.289005271304936 0.40197444318449 no 2042 0.386288671844768 3026 6624543 SGTC_265 mycophenolic acid 32.932 µM -0.289349408388659 0.401855425163095 no 2043 0.386157003032406 3168 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_2766 oltipraz 83.91 µM -0.289354288700369 0.401853737398085 no 2044 0.386155135891537 3063 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_1812 st052057 4.327 µM -0.290229275261211 0.401551169186311 no 2045 0.385820420589337 2886 3645418 SGTC_1383 3049-0032 20.7 µM -0.290552951220703 0.401439257774555 no 2046 0.385696623870794 3068 712864 SGTC_1701 st028638 40.4 µM -0.291795281502293 0.401009795493536 no 2047 0.385221576570204 3034 3490878 SGTC_2205 7238770 200 µM -0.292243589726306 0.400854848754772 no 2048 0.385050192891255 3044 279867 SGTC_1920 st075728 45.7 µM -0.29260280120513 0.400730707373645 no 2049 0.38491288619373 3120 3400306 SGTC_2201 6605497 169.863 µM -0.29327996915668 0.400496709371738 no 2050 0.384654081565484 2948 670741 SGTC_2764 methyldopa 94.69 µM -0.295108884673118 0.399864899226906 no 2051 0.383955351416127 3112 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_1698 5-fluorocytosine 1.055 µM -0.295643095313362 0.399680402245033 no 2052 0.383751329343575 3055 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_3204 9114183 49.47 µM -0.297776914314636 0.398943682330149 no 2053 0.382936717697395 2876 17027248 SGTC_2059 5238311 157 µM -0.298092578528212 0.398834726956574 no 2054 0.382816252855748 2909 703021 SGTC_1887 st057648 70.8 µM -0.298476196146513 0.398702327243957 no 2055 0.382669870665307 3066 688672 SGTC_2923 7992654 58.14 µM -0.300323611321755 0.398064883844979 no 2056 0.38196516238903 2968 2985126 SGTC_2741 miltefosine 3.04 µM -0.30134366057533 0.39771303626341 no 2057 0.381576225464771 2945 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_3135 9127742 49.47 µM -0.3020265199219 0.397477542721709 no 2058 0.381315923227765 2991 3643468 SGTC_1112 tnp00069 1.16933 µM -0.30240404949463 0.397347362431057 no 2059 0.381172034061254 3037 145826 SGTC_2873 9040596 71.43 µM -0.302554731409004 0.397295407268129 no 2060 0.381114608721631 3050 6463863 SGTC_1861 st057647 17.4 µM -0.302925698738656 0.39716750540468 no 2061 0.380973243093531 3116 688668 SGTC_1464 k208-0027 110 µM -0.303207521048511 0.397070346291192 no 2062 0.380865858841283 3134 X1464 SGTC_635 k038-0028 24.7 µM -0.306469854510643 0.39594611316283 no 2063 0.379623464451733 2988 4035102 SGTC_2107 5363541 170.161 µM -0.306516036173042 0.395930204681803 no 2064 0.379605885973863 3038 244052 SGTC_1842 st055362 61.2 µM -0.30769127186637 0.395525422423371 no 2065 0.379158630892333 2950 676032 SGTC_1478 0453-0656 35.7 µM -0.308338210762239 0.395302647611569 no 2066 0.378912496731041 3017 5258496 SGTC_2882 9058044 58.44 µM -0.311147308289297 0.39433572646863 no 2067 0.377844318993061 3032 18076804 SGTC_296 1222-0039 74.9 µM -0.311997573567845 0.394043184171697 no 2068 0.377521183686966 2988 5984176 SGTC_2675 theaflavin digallate 100 µM -0.312862424974852 0.393745684689824 no 2069 0.377192592989758 2985 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_3226 9131256 49.47 µM -0.316042844557884 0.39265218945704 no 2070 0.375984994111811 2961 17178073 SGTC_775 4577-0580 57.3 µM -0.316520265411694 0.392488115002739 no 2071 0.375803822839043 3157 2006902 SGTC_772 k072-0172 35.3 µM -0.317101529222714 0.392288378802601 no 2072 0.375583282284387 2968 5861980 SGTC_1258 0671-0043 57.1 µM -0.317336300005301 0.392207713966764 no 2073 0.375494218108281 2999 4298767 SGTC_2433 5607874 27.82 µM -0.318260378090659 0.391890255230011 no 2074 0.375143718314299 2961 2252428 SGTC_2643 anethole 100 µM -0.319727958415251 0.391386229147904 no 2075 0.374587281828664 3027 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_173 1273-0061 2.693 µM -0.320581402239595 0.391093206010715 no 2076 0.374263816590745 3071 2847414 YPL266W DIM1 SGTC_2034 5197015 53.07 µM -0.321417815470821 0.39080609016185 no 2077 0.373946892002726 3120 780676 SGTC_2854 9024559 71.43 µM -0.324459819503265 0.389762363362939 no 2078 0.372794968794025 3061 3163529 SGTC_582 0987-0078 156 µM -0.326769600569079 0.388970396102896 no 2079 0.371921076774391 3108 1625765 SGTC_3039 9090270 49.47 µM -0.327295609090887 0.388790105030875 no 2080 0.371722156580622 3117 17173750 SGTC_2312 7706453 155.7 µM -0.32820629887947 0.388478019892973 no 2081 0.371377842793374 3016 976098 SGTC_1129 3453-1384 223 µM -0.330006388870168 0.387861357290287 no 2082 0.370697567342419 3188 1084452 SGTC_51 1013-0126 23.419 µM -0.3330637750449 0.386814627284914 no 2083 0.369543071527825 3272 1627850 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.335338603373695 0.38603634798289 no 2084 0.368684838268553 3142 5357218 A potent inhibitor of glutathione S-transferases. SGTC_668 1682-0499 62.6 µM -0.336719072749827 0.385564275970438 no 2085 0.368164342085756 3038 682214 SGTC_1716 st033144 30.6155 µM -0.337102743630976 0.385433104078177 no 2086 0.368019724620442 3167 674617 SGTC_2784 7567673 72.73 µM -0.339292603409653 0.3846846718623 no 2087 0.36719465708064 3019 3471247 SGTC_2781 5567276 71.43 µM -0.340131190706864 0.384398180000708 no 2088 0.366878866889375 3150 2853274 SGTC_2404 5161160 200 µM -0.340219039003278 0.384368171484432 no 2089 0.36684579071107 2934 2831543 SGTC_2041 5107442 45.335 µM -0.340404478566635 0.384304828579963 no 2090 0.366775973228579 3167 793005 SGTC_1865 st057639 52.2 µM -0.340512407218629 0.384267963466461 no 2091 0.366735340418518 2972 688818 SGTC_1798 st045719 60.953 µM -0.340912776146395 0.38413121888143 no 2092 0.366584623198305 3080 3980186 SGTC_2691 st077356 60.2 µM -0.341050599754845 0.384084149053561 no 2093 0.366532744831523 3169 2839272 SGTC_42 0133-0086 60.653 µM -0.341223880993324 0.384024972082459 no 2094 0.366467523271609 2939 162923 Model of phenazepam hydroxylation. SGTC_415 dibenzyl ketone 100 µM -0.341839620642184 0.383814713800537 no 2095 0.366235795401235 3074 7593 SGTC_597 k018-0003 82.8 µM -0.342175241960547 0.383700122678761 no 2096 0.366109507981671 3128 6786234 SGTC_2413 inermin 26.06 µM -0.343240703366107 0.383336409831215 no 2097 0.365708692860407 3284 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_1863 st057641 20.1 µM -0.343543620030134 0.383233022978731 no 2098 0.365594765608158 3060 3921635 SGTC_603 3794-0023 45.9 µM -0.344576194558981 0.382880663064436 no 2099 0.365206502461468 3114 3802260 SGTC_2178 5812956 200 µM -0.344761898126175 0.382817303099653 no 2100 0.365136689843446 2958 5403383 SGTC_2696 st077691 74.316 µM -0.345427934088712 0.382590084936206 no 2101 0.364886339861455 3176 757133 SGTC_2595 hexamethylquercetagetin 100 µM -0.347380229334309 0.381924292525423 no 2102 0.364152842176416 3062 386331 SGTC_2965 9082772 38.63 µM -0.347732650984509 0.381804143097831 no 2103 0.364020486601368 3210 16459634 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.349847878418456 0.381083248336857 no 2104 0.36322643249882 3220 551469 SGTC_2950 9072895 21.46 µM -0.349929376836292 0.38105548094045 no 2105 0.363195849812335 3155 17332245 SGTC_3219 9131112 49.47 µM -0.351625240105549 0.380477821067825 no 2106 0.362559666852161 3135 17612988 YMR079W SEC14 SGTC_2823 7987624 58.44 µM -0.352152172800135 0.380298386805783 no 2107 0.362362071462785 3259 2239440 SGTC_2243 6634756 200 µM -0.35303606924489 0.379997454974649 no 2108 0.362030699982492 3251 885676 SGTC_2987 9018338 71.43 µM -0.356125134567828 0.378946321885574 no 2109 0.360873427442167 3157 5055682 SGTC_278 4092-0821 23.9 µM -0.356837306880099 0.378704113749618 no 2110 0.360606802779463 3111 877900 SGTC_1329 1447-1697 50.6 µM -0.357696482777011 0.378411973441516 no 2111 0.360285232765333 3125 2840515 SGTC_2335 9018011 154.17 µM -0.358181506787106 0.37824708437682 no 2112 0.360103742922222 3119 6458208 SGTC_838 0109-0203 71.4 µM -0.358631595399219 0.378094091804037 no 2113 0.359935353664303 3035 759422 SGTC_2614 arthonioic acid 13.39 µM -0.358962512710352 0.377981619721561 no 2114 0.359811566666529 3016 6710684 SGTC_2885 9057732 51.95 µM -0.35905669503994 0.377949610947982 no 2115 0.359776338353784 3178 6471414 SGTC_3160 9100216 49.47 µM -0.359075692918254 0.377943154437251 no 2116 0.359769232460313 3058 17191039 SGTC_1305 1181-0477 144 µM -0.359170407541368 0.377910965773567 no 2117 0.359733806489594 3166 6252086 SGTC_1568 digitonin 820 nM -0.359542902941331 0.377784381832935 no 2118 0.359594494277074 3206 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_2279 7948423 32.93 µM -0.359883838915771 0.377668534134659 no 2119 0.359467001551407 3217 1247112 SGTC_1068 loratadine 26.9 µM -0.360359432498598 0.377506949089989 no 2120 0.359289179856494 3077 3957 A H1 histamine antagonist. SGTC_1011 4112-3381 17.4 µM -0.366678819213226 0.375361954350857 no 2121 0.356929303774733 3213 2877139 SGTC_1358 1509-0022 2.48 µM -0.366953187927476 0.37526891183275 no 2122 0.356826968201386 3120 3258434 SGTC_1578 josamycin 24.2 µM -0.367084663938857 0.375224328930086 no 2123 0.356777933196318 3054 5282165 A P450 substrate. SGTC_793 0488-0545 106 µM -0.368341659864858 0.374798171692684 no 2124 0.356309246325475 3028 292548 SGTC_802 4112-3352 742 µM -0.369473184030072 0.374414683635443 no 2125 0.355887528723935 3194 704594 SGTC_85 0868-0259 160.055 µM -0.369732954346622 0.374326661658778 no 2126 0.355790737522809 3098 83173 SGTC_840 0245-0196 390 µM -0.370438452217605 0.374087640013983 no 2127 0.355527913816668 3192 3827528 SGTC_482 fipronil 114 µM -0.371490171385513 0.373731408979425 no 2128 0.355136237579186 3119 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.372015548241929 0.373553497340483 no 2129 0.354940636516739 3305 6728940 SGTC_102 gallobenzophenone 83.616 µM -0.373842932826138 0.372934888791514 no 2130 0.354260587912526 3236 70837 SGTC_2423 st077119 87.2 µM -0.373990580151864 0.37288492130964 no 2131 0.354205662227435 3105 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_398 bronopol 33.3 µM -0.375160212256655 0.372489164709841 no 2132 0.353770659373401 3029 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_2480 5767542 37.17 µM -0.376332981081612 0.372092481902281 no 2133 0.353334681534354 3088 2867358 SGTC_1252 0493-0875 34.8 µM -0.379158566572302 0.371137300758809 no 2134 0.352285058753551 3052 3960963 SGTC_1165 k072-0275 30.3 µM -0.380206811958412 0.370783145805987 no 2135 0.351895951531834 3209 6153523 YGL055W OLE1 SGTC_1988 st071872 53.4 µM -0.383281124664777 0.369745106055184 no 2136 0.350755666489992 3204 16414116 SGTC_1276 0871-0068 94.2 µM -0.38543609027525 0.36901804820853 no 2137 0.349957173988626 3152 3414906 SGTC_824 1304-0008 100 µM -0.388682088775713 0.367923774642883 no 2138 0.348755666833567 3099 768245 SGTC_1492 4158-0558 28.5 µM -0.389834562411108 0.367535516092637 no 2139 0.34832944229365 3173 3967268 SGTC_956 1185-0240 191 µM -0.390131229265036 0.367435593447341 no 2140 0.348219755613476 3087 1416193 SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.391497914561663 0.366975385665724 no 2141 0.34771461492493 3210 61125 An anti-inflammatory. SGTC_2145 5634607 200 µM -0.392378670789585 0.366678907357738 no 2142 0.34738922165401 3085 308662 SGTC_1317 1273-0028 910 nM -0.394276919257696 0.366040193551838 no 2143 0.346688300892834 3095 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_3280 9140961 49.47 µM -0.394379999349445 0.366005520248295 no 2144 0.34665025396749 3074 4901226 SGTC_3098 9119039 49.47 µM -0.395463011748335 0.365641290904497 no 2145 0.346250606981124 3137 17161528 SGTC_831 k061-1017 217 µM -0.400025198141875 0.364108308945516 no 2146 0.344568978713199 3182 1240153 SGTC_1619 st003326 88.7 µM -0.401054020548034 0.363762904163436 no 2147 0.344190175981549 3254 2849032 SGTC_2087 5276107 200 µM -0.401426717410307 0.36363780658103 no 2148 0.344052991042903 3081 144405 SGTC_1844 rapamycin 4 nM -0.402458437965572 0.363291580227866 no 2149 0.343673335019456 3081 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_3224 9130643 49.47 µM -0.402709291242157 0.363207415368485 no 2150 0.343581048987834 3291 17644395 SGTC_454 lyso-paf C-16 6.67 µM -0.402853312212723 0.363159097258755 no 2151 0.343528069543505 3161 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2350 9023895 38.85 µM -0.403013516202913 0.363105352408499 no 2152 0.34346914063719 3250 2997209 SGTC_2922 7999257 32.47 µM -0.405294183448325 0.362340532428737 no 2153 0.342630640748147 3185 2988377 SGTC_1136 pergolide 1.05886 µM -0.405411988214809 0.362301041581864 no 2154 0.342587350186427 3065 47811 A dopamine receptor agonist. SGTC_3279 9140807 49.47 µM -0.40666030098491 0.361882668755401 no 2155 0.342128750873691 3167 45595718 SGTC_41 0478-0632 82.643 µM -0.40670183884537 0.361868750148762 no 2156 0.342113494886449 3223 3750424 SGTC_1220 1838-0075 193 µM -0.407107368736435 0.361732873814861 no 2157 0.341964565784373 3138 5529645 SGTC_677 0929-0063 136 µM -0.407735714049728 0.361522375658827 no 2158 0.341733857246243 3177 1539583 SGTC_920 mycophenolic acid 780.421 nM -0.408237778514408 0.361354212199876 no 2159 0.341549557517543 3122 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_784 4579-0127 173 µM -0.408240482060996 0.361353306735754 no 2160 0.341548565191611 3315 1948547 SGTC_2824 7998404 51.95 µM -0.408680103457086 0.361206080324252 no 2161 0.341387218494528 3085 837851 SGTC_2190 6049624 200 µM -0.409648920075746 0.360881702386816 no 2162 0.34103175271612 3197 2265554 SGTC_795 0685-0265 78 µM -0.409783622267026 0.360836609488683 no 2163 0.340982340676778 3146 302754 SGTC_262 fenpropimorph 62.5 µM -0.411556425182183 0.360243326563264 no 2164 0.340332287893479 3179 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_813 k007-0158 173 µM -0.412345685219936 0.359979302402681 no 2165 0.340043033818301 3176 6523916 SGTC_3106 9121286 49.47 µM -0.412804184174281 0.359825955474329 no 2166 0.339875042813982 3319 15943471 SGTC_342 k048-0088 23.3 µM -0.413106906783699 0.35972472097194 no 2167 0.339764144662255 3106 6820570 SGTC_171 k064-0041 9.68 µM -0.414855745844685 0.359140078574667 no 2168 0.339123753907091 3135 53325 SGTC_2009 4012297 12.05 µM -0.415231300516462 0.359014572425822 no 2169 0.338986293633401 3218 45595307 SGTC_591 4299-0174 154 µM -0.41876201024434 0.357835394572779 no 2170 0.337695035759667 3165 5509088 SGTC_1850 st056238 17 µM -0.419077530655578 0.357730083640578 no 2171 0.337579735699268 3181 5393177 SGTC_2013 4024628 200 µM -0.419461048619421 0.357602091814889 no 2172 0.337439607942523 3274 5230760 SGTC_1228 0124-0032 52.5 µM -0.421639737228967 0.356875300169804 no 2173 0.336643998506616 3229 X1228 SGTC_111 0083-0039 52.457 µM -0.422254109081774 0.356670444774681 no 2174 0.336419775253954 3083 759313 SGTC_1463 k081-0032 34.1 µM -0.426813938634351 0.35515131623288 no 2175 0.334757426637052 3217 977755 SGTC_570 0987-0065 62.6 µM -0.426857424548532 0.355136839728221 no 2176 0.334741588762565 3156 3104428 SGTC_3314 9135860 59.4275 µM -0.427374382747157 0.354964759845223 no 2177 0.334553331493913 3269 25252478 SGTC_2227 7312221 64.1025 µM -0.428879930866647 0.354463776654063 no 2178 0.33400530300737 3195 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_2697 mebhydrolin 72.4 µM -0.429945962488161 0.354109198239531 no 2179 0.33361747500178 3323 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_3257 9139206 32.98 µM -0.430047766744436 0.354075343197916 no 2180 0.333580447359288 3253 4910041 SGTC_3259 9138485 49.47 µM -0.430966771041674 0.353769780227101 no 2181 0.333246265951648 3443 17646153 SGTC_1968 st069590 43.6 µM -0.431846509931359 0.353477360973604 no 2182 0.332926486756328 3256 6384066 SGTC_888 0916-0002 6.97 µM -0.433783070477693 0.35283396619755 no 2183 0.332222988229268 3313 2802138 YIL048W NEO1 SGTC_3055 9094636 49.47 µM -0.435220412883428 0.35235670140901 no 2184 0.331701223565219 3348 25236176 SGTC_1964 st076914 61 µM -0.43586233849112 0.352143627158655 no 2185 0.331468305735545 3216 24208661 SGTC_3249 9135183 49.47 µM -0.438147457769671 0.351385504993245 no 2186 0.330639696933049 3317 4902779 SGTC_1126 isoteolin 1.0172 µM -0.438258536080644 0.35134866815363 no 2187 0.330599439848986 3152 133323 SGTC_2170 morpholine 200 µM -0.439041965663118 0.351088899499166 no 2188 0.330315564392916 3281 121171 Reacts with secondary amines. SGTC_141 0443-0274 32.331 µM -0.439500790507548 0.350936795194403 no 2189 0.330149354679875 3337 1627241 SGTC_475 α-linolenic acid 10 µM -0.439694132813512 0.350872707740794 no 2190 0.330079326290289 3399 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2098 5376439 882.5 nM -0.440425157511746 0.350630432285984 no 2191 0.329814603699814 3257 2844116 SGTC_2341 7987486 176.74 µM -0.441262391841546 0.350353031564521 no 2192 0.329511524601599 3316 1258686 SGTC_3233 9132340 49.47 µM -0.441717373681749 0.350202315959784 no 2193 0.329346867966194 3185 17682950 SGTC_1940 st075990 51.1 µM -0.441901428803697 0.35014135323951 no 2194 0.329280268338943 3420 1084979 SGTC_1835 st008666 49.2 µM -0.442723555150824 0.349869095793938 no 2195 0.328982851288498 3145 690455 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.443241211128441 0.349697707112607 no 2196 0.328795636670669 3266 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1152 3909-8331 15.9 µM -0.443324237392406 0.349670221122642 no 2197 0.32876561352307 3206 16001939 SGTC_2836 9010338 19.48 µM -0.44416828594703 0.349390842117527 no 2198 0.328460459667869 3173 2994051 SGTC_1955 wogonin 32.4 µM -0.445120510988143 0.349075754762378 no 2199 0.328116333447236 3382 5281703 A flavanone. SGTC_688 0527-0193 473 µM -0.445185102535019 0.349054385449693 no 2200 0.328092995877316 3195 4007154 SGTC_991 3996-0057 64.7 µM -0.446693196363083 0.348555587481144 no 2201 0.327548297451053 3254 715343 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.447681600683729 0.348228817334882 no 2202 0.327191501163793 3208 2724278 An inhibitor of dopamine biosynthesis. SGTC_936 3005-4620 401 µM -0.454639903869484 0.345931576177922 no 2203 0.324684160995678 3385 777207 SGTC_1279 0874-0590 65.2 µM -0.457851878914748 0.344873066153761 no 2204 0.323529430480523 3255 3523074 SGTC_33 0986-0033 35.816 µM -0.458458986965346 0.344673129062083 no 2205 0.323311360714965 3270 2848082 SGTC_656 4090-1979 187 µM -0.459319719844652 0.344389740814604 no 2206 0.323002294378592 3336 22330961 SGTC_1072 oxiconazole 14.9 nM -0.459682124817674 0.344270448485631 no 2207 0.322872200906236 3306 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2449 5812982 45.77 µM -0.459842269235606 0.344217738910517 no 2208 0.322814720343732 3292 776185 SGTC_3263 9137018 49.47 µM -0.459985759637225 0.344170513371411 no 2209 0.322763220995027 3257 43844957 SGTC_713 1488-1073 324 µM -0.460364750593266 0.344045791612818 no 2210 0.322627215788067 3287 3312542 SGTC_1737 st035557 69.7 µM -0.460555946020428 0.343982877736095 no 2211 0.322558612141983 3232 5716916 SGTC_2478 5763493 32.33 µM -0.461870566637288 0.343550411824756 no 2212 0.322087071179669 3191 1365576 YLR208W SEC13 SGTC_631 k072-0230 41.5 µM -0.462255036024908 0.343423973006862 no 2213 0.321949220010972 3286 5773147 SGTC_248 streptozotocin 5.23457 mM -0.462272726032926 0.343418155790415 no 2214 0.321942877863175 3287 5300 DNA alkylating agent. SGTC_2459 5811157 9.22 µM -0.462303062281556 0.343408180046095 no 2215 0.321932001958738 3288 2870684 YBR192W RIM2 SGTC_2198 6589944 200 µM -0.462984950126109 0.343183977464842 no 2216 0.321687577351417 3275 5290268 SGTC_1987 st072290 61.9 µM -0.463503152687798 0.343013630991328 no 2217 0.321501877783054 3246 54697379 SGTC_1483 3453-0561 55.9 µM -0.463616212349148 0.342976469619067 no 2218 0.321461368411948 3297 4546991 SGTC_1530 rhein 70.4 µM -0.46615451480106 0.342142560090772 no 2219 0.320552452243234 3280 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_1944 st076371 56.9 µM -0.466457229662523 0.342043160320012 no 2220 0.320444127652257 3199 24208455 SGTC_2409 alverine citrate 63.97 µM -0.468663733230765 0.341318961535417 no 2221 0.319655006901251 3411 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_719 2810-4230 27.3 µM -0.469685684460132 0.340983743582836 no 2222 0.319289798545644 3276 721079 SGTC_1313 1220-0047 237 µM -0.471085476109913 0.340524791038392 no 2223 0.318789848197844 3285 3528706 SGTC_2962 9082311 13.18 µM -0.471879226155877 0.340264647419284 no 2224 0.318506498376875 3192 16459453 SGTC_2460 5552655 174.22 µM -0.472444408885287 0.340079460765158 no 2225 0.31830480630065 3338 5401989 SGTC_2022 5136654 200 µM -0.472849794136661 0.339946656789587 no 2226 0.318160172986266 3328 1713771 SGTC_649 1123-0311 367 µM -0.473616983071655 0.339695380500705 no 2227 0.317886531274722 3292 693629 YIL048W NEO1 SGTC_2118 5526350 200 µM -0.473694744559256 0.339669915366244 no 2228 0.317858800776716 3308 743594 SGTC_2586 curcumin 80 µM -0.474586513556523 0.339377933464552 no 2229 0.31754086039052 3321 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_2005 4024620 188 µM -0.475265371388809 0.339155727288648 no 2230 0.317298918916487 3284 236743 SGTC_456 gingerol 170 µM -0.475484656497278 0.339083962050145 no 2231 0.317220783493642 3404 442793 A herb. SGTC_179 1273-0063 6.77 µM -0.47595651643206 0.338929556678276 no 2232 0.317052678522143 3206 3108139 SGTC_1613 st002381 52.1 µM -0.478337568350752 0.338150825085728 no 2233 0.316204980652945 3323 551167 SGTC_3168 9103419 49.47 µM -0.479235547179374 0.337857317382461 no 2234 0.31588553420464 3290 16649256 SGTC_2028 5153890 36.43 µM -0.479631367544265 0.337727973318316 no 2235 0.315744768938201 3271 2830968 YPR165W RHO1 SGTC_1531 st059297 52.4 µM -0.48174244637041 0.33703845022983 no 2236 0.314994459458841 3344 7566702 SGTC_2266 7929956 200 µM -0.483042338237476 0.336614150025834 no 2237 0.314532837371531 3325 2967153 SGTC_592 k241-0073 46.5 µM -0.485672526310847 0.33575626170481 no 2238 0.313599682837487 3361 4230158 SGTC_197 4544-0043 41.561 µM -0.48792220751768 0.335023161620544 no 2239 0.312802471932799 3324 896523 SGTC_1549 4'-methoxyflavonol 74.6 µM -0.490101899890994 0.334313467665655 no 2240 0.312030896875543 3331 97141 SGTC_617 3770-0098 35 µM -0.49186642728436 0.333739382093639 no 2241 0.311406886614881 3282 5962639 SGTC_180 1486-1293 102.781 µM -0.492093313333814 0.333665593353848 no 2242 0.311326689521231 3436 4140536 SGTC_980 1473-0395 201 µM -0.493017290813443 0.333365160372593 no 2243 0.311000185006689 3254 768876 SGTC_3074 9116018 49.47 µM -0.494224566557671 0.332972773492761 no 2244 0.3105737959281 3258 17027303 SGTC_1280 0880-0253 10.1 µM -0.494655937544587 0.332832614276472 no 2245 0.310421504746322 3285 6836607 SGTC_657 3534-0529 86.7 µM -0.494714819268771 0.332813484489686 no 2246 0.310400719666524 3368 1049549 SGTC_2710 st078562 53.7235 µM -0.494806530946903 0.332783689611376 no 2247 0.310368346913066 3282 17250908 SGTC_1898 st060199 18.6 µM -0.495156085848454 0.332670137467999 no 2248 0.310244973103298 3280 688866 SGTC_961 1252-1571 372 µM -0.496153874574055 0.332346092458122 no 2249 0.309892925620115 3427 6813498 SGTC_1078 idebenone 36.1 µM -0.496460963645847 0.332246386444959 no 2250 0.309784611147633 3330 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_1752 st044819 83.042 µM -0.498093718392151 0.331716461381831 no 2251 0.309208993921427 3254 441209 YML126C ERG13 SGTC_3125 9127534 49.47 µM -0.500727073430194 0.330862492088477 no 2252 0.308281607926695 3307 1639235 SGTC_848 0368-0089 85.6 µM -0.501401531011277 0.330643913882698 no 2253 0.308044281263136 3358 762535 SGTC_923 1900-2434 73.3 µM -0.502555175139803 0.330270174789821 no 2254 0.307638525540348 3330 5910570 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.50289284096296 0.330160815246385 no 2255 0.307519807358267 3308 2374 Ca(2+)-ATPase inhibitor. SGTC_1092 toremifene 6.32 µM -0.503289200800219 0.330032465033147 no 2256 0.307380478969925 3329 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2079 5212404 121 µM -0.504143085974981 0.329756025826551 no 2257 0.3070804157467 3413 758462 SGTC_2560 caryophyllene 100 µM -0.504648918014623 0.329592310168363 no 2258 0.306902722545907 3292 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_556 4058-0063 51.5 µM -0.505041499815641 0.329465271150921 no 2259 0.306764844158594 3339 6615692 SGTC_461 N-acetylfarnesylcysteine 136 µM -0.508504072980448 0.328345640161539 no 2260 0.305549941728722 3389 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_834 0312-0008 75.7 µM -0.512145201423603 0.327169933785143 no 2261 0.304274695748019 3367 6385573 YIL048W NEO1 SGTC_530 4358-1714 28 µM -0.512871342391144 0.326935670146906 no 2262 0.304020660443291 3373 1564641 SGTC_2122 5258151 111.688 µM -0.515829760777729 0.325981946970889 no 2263 0.302986657367935 3305 2173356 SGTC_300 r073-0011 5.04 µM -0.517018437193961 0.325599066117322 no 2264 0.30257164421629 3419 2735780 SGTC_1840 st055363 71 µM -0.517252334914944 0.325523747696493 no 2265 0.302490011436749 3333 676033 SGTC_2878 9043973 25.97 µM -0.517737585246523 0.325367512853198 no 2266 0.302320685437217 3425 6465167 SGTC_1855 st056195 39.6 µM -0.518726624530341 0.325049169364878 no 2267 0.301975696196129 3426 4028379 SGTC_2284 7945075 39.21 µM -0.519332670592069 0.324854163524238 no 2268 0.301764387186928 3385 1245402 SGTC_697 0508-1955 564 µM -0.521145457254149 0.3242711545429 no 2269 0.301132723218182 3439 6243113 SGTC_1560 lithocholic acid 53.1 µM -0.521313497876551 0.324217132907437 no 2270 0.301074199791395 3357 9903 A bile acid which acts as a detergent. SGTC_402 epigallocatechin gallate 10 µM -0.521569683178829 0.324134781674997 no 2271 0.300984988125171 3323 65064 An antioxidant. SGTC_1666 st014829 29 µM -0.523176447984631 0.323618480541087 no 2272 0.30042573478233 3362 3858230 SGTC_1567 st069303 68.4 µM -0.524799009584582 0.323097447742278 no 2273 0.299861460058898 3400 5581319 SGTC_1246 0422-0085 105 µM -0.525614933013715 0.322835571526248 no 2274 0.299577889556184 3449 264295 SGTC_2262 9014885 67.46 µM -0.526356079204827 0.322597771690788 no 2275 0.299320412923608 3350 6457424 SGTC_3250 9135583 49.47 µM -0.528688038694331 0.321850026395982 no 2276 0.298510938062597 3425 7699353 SGTC_778 3456-2434 196 µM -0.528945255644388 0.321767593593685 no 2277 0.29842171336911 3417 5539063 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.529794624193167 0.321495450572955 no 2278 0.298127166432365 3352 5379071 SGTC_83 0170-0301 39.027 µM -0.530270632114561 0.321342976513723 no 2279 0.29796215270572 3372 3089716 SGTC_5 0352-0601 109.883 µM -0.531245353341113 0.321030849400238 no 2280 0.297624384146953 3357 762456 SGTC_2831 7999036 19.48 µM -0.531714010797033 0.320880819994099 no 2281 0.297462043276306 3457 2988270 SGTC_86 0417-1630 471.922 µM -0.53492010156745 0.319855252589535 no 2282 0.296352553791899 3418 3634867 SGTC_2645 abamectin 100 µM -0.536415241027068 0.319377455726401 no 2283 0.295835800153822 3401 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_95 0471-0001 561.058 µM -0.536673340186503 0.319295006134349 no 2284 0.29574663721877 3375 4015405 SGTC_1189 1431-2119 7.28 µM -0.53714322568557 0.319144924491535 no 2285 0.295584342285762 3453 3107275 SGTC_2182 6325192 200 µM -0.537468415103188 0.319041076194272 no 2286 0.295472048275055 3413 736248 SGTC_1657 st012939 43.4 µM -0.539430141840383 0.31841490593341 no 2287 0.294795043793282 3458 24207257 SGTC_3140 9094243 49.47 µM -0.543763338205265 0.317033617183337 no 2288 0.293302170183587 3480 19291112 SGTC_2636 apigenin dimethyl ether 100 µM -0.543961807702913 0.316970412085603 no 2289 0.293233877431608 3456 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_347 4534-1311 26.2 µM -0.5441610352983 0.316906970933197 no 2290 0.29316533123527 3411 2862016 SGTC_966 1300-0360 30.2 µM -0.545053913251235 0.316622712978666 no 2291 0.292858219176396 3344 70588 SGTC_1659 st012954 42.1 µM -0.54509183775201 0.316610641673889 no 2292 0.292845178067269 3444 24207262 SGTC_3329 9141233 27.5565 µM -0.545411796650387 0.316508807071085 no 2293 0.292735164440627 3468 4909101 YNL103W MET4 SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.545670976223968 0.316426327144167 no 2294 0.292646063052087 3570 5282309 SGTC_1160 4092-0570 10.5 µM -0.54625460112439 0.316240630896512 no 2295 0.292445469194231 3404 4994975 SGTC_924 2046-0044 21.3 µM -0.546271697347007 0.316235191963334 no 2296 0.292439594128242 3432 3623589 SGTC_219 mitoxanthrone 164.414 µM -0.546419545408666 0.316188157750754 no 2297 0.292388788871257 3398 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_3143 9086658 49.47 µM -0.54804602490442 0.315670929901379 no 2298 0.291830150318167 3422 25236626 SGTC_601 0986-0029 62.9 µM -0.548570873830518 0.315504102518284 no 2299 0.29164998932776 3427 24747981 SGTC_3238 9133470 49.47 µM -0.55232767997071 0.31431107133323 no 2300 0.290361934726172 3483 3534688 SGTC_1765 st044815 90.4 µM -0.553005421589934 0.314096050023527 no 2301 0.290129848859527 3412 645695 SGTC_2943 9068529 45.32 µM -0.55501548238564 0.313458706405005 no 2302 0.289442035303626 3476 3270634 SGTC_2936 9038235 15.59 µM -0.555549044751091 0.313289619565315 no 2303 0.289259586751873 3420 4749415 SGTC_1187 1391-0724 117 µM -0.555942604072599 0.313164925078543 no 2304 0.289125046077951 3441 6997986 SGTC_576 1073-0113 22.7 µM -0.5560052466895 0.313145079497208 no 2305 0.289103634029154 3588 5439563 SGTC_781 4335-2806 94.4 µM -0.558210480911669 0.312446792445989 no 2306 0.288350332378132 3501 845254 SGTC_2511 berberine 10.47 µM -0.561156268014544 0.311515059464684 no 2307 0.287345506242087 3417 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_810 3825-7150 143 µM -0.561245473118847 0.311486863260316 no 2308 0.287315103691096 3502 22330411 YGL099W LSG1 SGTC_2431 5490079 200 µM -0.561320679269054 0.311463092744313 no 2309 0.287289473393972 3406 5722345 SGTC_3002 9075603 71.4286 µM -0.561825871452154 0.311303436299553 no 2310 0.287117331671536 3467 20105405 SGTC_2813 7971799 71.43 µM -0.562192382720686 0.311187629548021 no 2311 0.286992475355969 3456 2234054 SGTC_1213 1315-0166 115 µM -0.562724173551399 0.311019632560181 no 2312 0.286811360383232 3409 768401 SGTC_3285 9112818 20.8695 µM -0.56380850666116 0.310677205049545 no 2313 0.286442230938957 3465 17017947 YPR165W RHO1 SGTC_1782 st039423 80.636 µM -0.564423353312233 0.310483112062333 no 2314 0.286233024616524 3367 2068169 SGTC_1291 0993-0025 5.79 µM -0.564783599896044 0.310369414983297 no 2315 0.286110481655318 3510 4353356 SGTC_183 3914-0051 30.55 µM -0.565080171389036 0.310275827935816 no 2316 0.286009617384574 3460 1596232 SGTC_3225 9130819 49.47 µM -0.565955555289218 0.309999660658122 no 2317 0.28571199701362 3486 4547121 SGTC_1848 st056003 16.4 µM -0.568151591452013 0.309307324112762 no 2318 0.284966019301681 3508 146492 SGTC_3167 9103034 49.47 µM -0.568267428478234 0.309270823345549 no 2319 0.28492669610073 3475 5127859 SGTC_1033 k072-0102 21.3 µM -0.569171069894402 0.308986146511985 no 2320 0.284620025788273 3484 5965931 SGTC_1179 1021-1431 9.29 µM -0.569475742187646 0.308890190540799 no 2321 0.28451666417539 3426 2840958 SGTC_2393 9031399 185.94 µM -0.570832906744655 0.308462912608013 no 2322 0.284056457190272 3532 1526623 YDL150W RPC53 SGTC_1776 st049249 45.9 µM -0.570920472759236 0.308435352980986 no 2323 0.284026776272787 3433 1822314 SGTC_3294 9122953 26.2835 µM -0.573129545846028 0.307740449473346 no 2324 0.283278491727966 3486 16459826 SGTC_430 0958-0115 16.4 µM -0.573209044984451 0.307715454427195 no 2325 0.283251580431804 3371 6833180 SGTC_559 1550-0661 158 µM -0.573314956957184 0.307682156400605 no 2326 0.28321573001803 3473 5830875 SGTC_2228 7354201 200 µM -0.574838760598338 0.307203258038779 no 2327 0.282700174927653 3478 753451 SGTC_485 niflumic acid 177 µM -0.575236714142231 0.307078243974545 no 2328 0.282565607884458 3491 4488 A COX2 inhibitor. SGTC_343 4130-2827 29.8 µM -0.576592589650045 0.306652474459974 no 2329 0.282107353145379 3431 1118244 SGTC_2714 st079313 56.9 µM -0.576988295709659 0.306528264710444 no 2330 0.281973681081364 3469 2939799 SGTC_1461 k072-0203 53.8 µM -0.577412222490008 0.306395221301586 no 2331 0.281830509734222 3432 5418714 SGTC_292 k038-0015 474 µM -0.578370304856645 0.30609463476186 no 2332 0.281507068954197 3466 46368540 SGTC_2846 9008642 19.48 µM -0.579372982783013 0.305780196671056 no 2333 0.281168764962491 3476 2992898 SGTC_1127 asiatic acid 681.4 nM -0.58011454474307 0.305547736158616 no 2334 0.280918687991538 3418 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_101 0490-5701 117.494 µM -0.581128473838831 0.305230022417994 no 2335 0.280576934727573 3448 4661669 SGTC_2475 5812728 15.03 µM -0.583241117076957 0.30456849907761 no 2336 0.279865497678123 3494 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_424 splitomicin 100 mM -0.5838344181643 0.30438283590638 no 2337 0.279665859763279 3458 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_3266 9136860 49.47 µM -0.584404569418088 0.304204464558938 no 2338 0.279474076605061 3445 4871271 YPR165W RHO1 SGTC_3198 9112019 49.47 µM -0.584622713278765 0.304136230751022 no 2339 0.279400715923134 3483 45595555 SGTC_798 1287-0182 476 µM -0.584645244349948 0.304129183584934 no 2340 0.279393139370336 3542 1649755 SGTC_1933 st074711 15.9 µM -0.585498000895725 0.303862515777843 no 2341 0.279106455204475 3488 17250958 SGTC_2406 ethylparaben 405.7 µM -0.585876333795346 0.30374423968221 no 2342 0.278979311086694 3252 8434 A possible steroid mimic. SGTC_990 3985-0011 41.3 µM -0.588092799175812 0.303051731671965 no 2343 0.278235003087161 3428 5399565 YGL099W LSG1 SGTC_2391 6285546 200 µM -0.588242677191761 0.303004929591777 no 2344 0.278184707740641 3398 846083 SGTC_460 trequinsin 123 µM -0.588740236486559 0.302849581035558 no 2345 0.278017770974027 3523 5537 A vasodilator. SGTC_208 k072-0098 12.366 µM -0.58880312338481 0.302829948951859 no 2346 0.2779966751888 3503 5948901 SGTC_22 0964-0034 14.468 µM -0.588973814028533 0.302776665478752 no 2347 0.2779394199315 3489 138402 SGTC_2563 tomatine 8.54 µM -0.589399836169248 0.302643695027239 no 2348 0.277796543202597 3549 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_724 3910-0327 137 µM -0.591954590267373 0.301846852220546 no 2349 0.276940498361497 3498 2885483 SGTC_613 3914-0030 117 µM -0.592361770765132 0.301719937393358 no 2350 0.276804180090784 3311 1145395 SGTC_97 0535-0701 19.132 µM -0.593070994795982 0.301498935380701 no 2351 0.276566820427815 3489 2832013 YGL099W LSG1 SGTC_204 PMA1.184 62.41 µM -0.593487847519284 0.301369073483378 no 2352 0.276427356748475 3514 2252213 YGL008C PMA1 SGTC_2869 9037858 32.47 µM -0.594713727236432 0.300987321855285 no 2353 0.276017422181103 3492 27187042 SGTC_82 0054-0107 293.755 µM -0.595000692326869 0.300897989456746 no 2354 0.275921504101776 3521 3104697 SGTC_2810 7959871 45.46 µM -0.59540833996288 0.30077110907374 no 2355 0.275785276038333 3470 2974535 SGTC_321 4534-3890 65.3 µM -0.595920966403561 0.30061158829753 no 2356 0.275614012990783 3504 699746 SGTC_2596 sinensetin 100 µM -0.596074723943396 0.300563748969657 no 2357 0.275562654426988 3431 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_948 3448-0295 75.3 µM -0.59654441223211 0.300417633872073 no 2358 0.275405796861159 3536 678569 SGTC_880 0833-0487 87.2 µM -0.597105378170852 0.30024316531941 no 2359 0.275218513706246 3497 76075 SGTC_1975 st070967 30.8 µM -0.599008956501193 0.299651466555802 no 2360 0.274583455976477 3543 261391 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.599156962190545 0.299605483350133 no 2361 0.274534109716136 3467 689007 SGTC_3298 9116858 71.43 µM -0.601272788427952 0.298948476927179 no 2362 0.27382915535103 3534 2506942 SGTC_1223 0764-0573 147 µM -0.601928899958447 0.29874487416398 no 2363 0.273610733026329 3532 1609797 SGTC_2234 tolnaftate 200 µM -0.602085151139669 0.298696396012331 no 2364 0.273558729055116 3470 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_1612 st002233 45.4 µM -0.602144428157266 0.298678005789566 no 2365 0.273539001586194 3540 1035021 SGTC_1300 1094-0077 113 µM -0.602301631374274 0.298629237236162 no 2366 0.273486687560043 3489 5532636 SGTC_971 1315-0384 26.7 µM -0.602822744828142 0.298467600103303 no 2367 0.273313307052615 3496 6769120 SGTC_504 lovastatin 124 µM -0.603399766611171 0.29828866797947 no 2368 0.27312138872921 3465 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_1347 1493-0251 600 nM -0.604148173461348 0.298056662820968 no 2369 0.272872566999286 3537 3986378 SGTC_992 3909-8734 162 µM -0.605448477163612 0.297653766017338 no 2370 0.272440524462467 3484 4288319 SGTC_2567 aureobasidin a 60 nM -0.606118034198589 0.297446401935922 no 2371 0.272218188155805 3587 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_3087 9117406 49.47 µM -0.607953989051502 0.296878139260356 no 2372 0.271608995235681 3520 42546093 SGTC_3223 9129970 49.47 µM -0.610203826186598 0.2961824504557 no 2373 0.270863397754998 3555 17248386 SGTC_3337 9144342 33.5465 µM -0.610320833807526 0.296146290130476 no 2374 0.270824649315671 3514 17682949 SGTC_3120 9124077 49.47 µM -0.614387712188737 0.294890712730922 no 2375 0.269479576861461 3555 18774327 YGL155W CDC43 SGTC_2147 5545932 89.7195 µM -0.614979402157434 0.294708243453079 no 2376 0.269284161702414 3525 797404 SGTC_451 chloral hydrate 100 µM -0.615435114743916 0.294567743287639 no 2377 0.26913370372972 3579 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_861 0443-0273 110 µM -0.616213700515081 0.294327770038939 no 2378 0.268876743644935 3519 6149169 SGTC_3282 9108498 15.4605 µM -0.616509095062267 0.294236748093604 no 2379 0.268779285530609 3505 16459645 SGTC_1610 st001799 48.1 µM -0.617118284223376 0.294049075536022 no 2380 0.268578354700062 3471 621897 SGTC_252 miconazole 1.30953 nM -0.617336766657497 0.293981781260701 no 2381 0.268506310330383 3499 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_519 k048-0011 62.8 µM -0.617485158734337 0.293936079417097 no 2382 0.268457383728393 3528 6836379 SGTC_2721 ifenprodil 61.44 µM -0.617741646272401 0.293857094043702 no 2383 0.268372827360595 3569 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_2241 6772625 37.8075 µM -0.619046803484597 0.293455322868774 no 2384 0.267942763162303 3513 2285411 SGTC_135 0933-0004 26.348 µM -0.624135992842137 0.291891135499703 no 2385 0.266269139007609 3537 21230617 YGL099W LSG1 SGTC_396 dithiazanine 1.25 µM -0.624519794897303 0.29177332969139 no 2386 0.266143137264399 3497 10578 An antihelmenthic. SGTC_2108 5365811 200 µM -0.625725353389884 0.29140343468708 no 2387 0.265747550346012 3557 780283 SGTC_312 4092-0653 6.84 µM -0.626460927419031 0.291177850002737 no 2388 0.265506328669736 3550 1148278 SGTC_1662 st014054 52 µM -0.626610324123695 0.291132043220834 no 2389 0.265457349591293 3543 2838777 SGTC_2419 paclitaxel 166.5 µM -0.626998294280805 0.291013102739998 no 2390 0.265330176629477 3499 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2146 5545642 200 µM -0.627383296345186 0.290895094637799 no 2391 0.265204007158312 3570 825326 SGTC_1338 1486-1223 76 µM -0.629883604396249 0.290129262763296 no 2392 0.264385370352065 3548 3444526 SGTC_3110 9122132 49.47 µM -0.631638045245141 0.289592451008803 no 2393 0.263811710137118 3637 918317 SGTC_2014 4013930 200 µM -0.631697071926716 0.289574398541476 no 2394 0.263792420865123 3552 64556 SGTC_2450 5739737 12.93 µM -0.631893542576967 0.289514314606334 no 2395 0.263728221593303 3564 2262825 SGTC_820 1582-0060 59.9 µM -0.636939226263551 0.287973271776925 no 2396 0.262082215307919 3527 3848840 SGTC_643 k048-0106 28.4 µM -0.637374552738981 0.287840496887743 no 2397 0.261940449950402 3577 6763920 SGTC_669 0108-0021 26.2 µM -0.637388120727454 0.287836359106137 no 2398 0.261936032126646 3694 17201 SGTC_1385 3091-4834 14.1 µM -0.637870573192945 0.287689245542363 no 2399 0.261778967356685 3547 4072814 SGTC_2864 9034755 47.6 µM -0.639495300528713 0.287194081167778 no 2400 0.261250384937684 3577 4930451 SGTC_2055 5235184 200 µM -0.64072610882794 0.286819239348489 no 2401 0.260850323968363 3590 2836034 SGTC_534 k292-0788 63.4 µM -0.641871109637532 0.28647073846716 no 2402 0.260478436946086 3630 4146317 SGTC_2977 9011197 71.43 µM -0.642047081981514 0.286417196046471 no 2403 0.260421306763317 3605 2704722 SGTC_2502 avocadyne acetate 18.59 µM -0.642171061843258 0.286379476028185 no 2404 0.260381060040356 3570 3952079 SGTC_1249 0481-0015 10.2 µM -0.64259316790846 0.286251070850335 no 2405 0.260244058702182 3546 4227577 SGTC_1227 3909-8010 46.6 µM -0.643731552686016 0.285904909175808 no 2406 0.259874762809764 3564 15982272 SGTC_2119 5528445 120.635 µM -0.644845940568111 0.285566237397608 no 2407 0.25951351362219 3594 791935 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.646957886015083 0.284924923894517 no 2408 0.258829600064393 3598 442882 SGTC_1394 3474-0001 65.7 µM -0.6470550395235 0.284895438788656 no 2409 0.258798161192876 3508 5017666 YIL048W NEO1 SGTC_755 1995-0008 37.3 µM -0.647961639561984 0.284620365046826 no 2410 0.258504880747418 3598 689533 SGTC_2867 9039098 71.43 µM -0.648031357613993 0.284599216973597 no 2411 0.258482334446449 3576 6463460 SGTC_2525 harmine 47.85 µM -0.650331906635923 0.283901796283278 no 2412 0.257738925700876 3553 5280953 A monoamine oxidase inhibitor SGTC_2383 9036125 200 µM -0.651042683202536 0.283686487028232 no 2413 0.257509467104589 3551 79580 SGTC_2887 9044784 58.44 µM -0.651344696021591 0.283595024639319 no 2414 0.257412001034575 3614 6465546 SGTC_2952 9073731 13.78 µM -0.653562269655619 0.282923881645877 no 2415 0.256696929565109 3583 16457353 SGTC_833 3852-0053 558 µM -0.654292745162396 0.282702972205862 no 2416 0.256461609500906 3647 3123681 SGTC_2947 9072639 7.68 µM -0.655985407332812 0.28219139832914 no 2417 0.255916756730936 3614 16488146 SGTC_423 5-fluorouracil 457 µM -0.657351203167977 0.281778938472403 no 2418 0.255477560038988 3575 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2465 5809242 33.21 µM -0.657600776274689 0.28170360072146 no 2419 0.25539734780779 3604 2731748 SGTC_690 glyoxal 20.3 µM -0.657689551870877 0.281676804687938 no 2420 0.255368818706043 3530 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_3248 9135562 49.47 µM -0.657966814626128 0.281593123587971 no 2421 0.255279727722271 3635 17650701 SGTC_1082 camptothecin 424.86 nM -0.660072718644008 0.280957929119862 no 2422 0.254603582450547 3551 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_3134 9127454 49.47 µM -0.660282795140472 0.280894602683926 no 2423 0.254536184415514 3692 24262820 SGTC_2448 5185112 27.17 µM -0.66104149590529 0.280665953870725 no 2424 0.254292851222596 3599 5718189 SGTC_71 0417-1750 47.813 µM -0.661383272134787 0.280562982568232 no 2425 0.254183275397213 3601 6811472 SGTC_1363 1636-0063 10.4 µM -0.6630283707708 0.280067598566598 no 2426 0.253656192017922 3645 6072185 SGTC_2925 9010536 32.5 µM -0.663527538071431 0.279917369578523 no 2427 0.253496374292465 3618 2994177 SGTC_3193 9111931 49.47 µM -0.663802817719889 0.279834538358394 no 2428 0.253408261016349 3649 17087244 SGTC_2194 5927483 104.545 µM -0.664211431370516 0.279711609069685 no 2429 0.253277499023493 3639 760979 SGTC_3017 9080681 49.47 µM -0.665974909572121 0.27918137663152 no 2430 0.25271356891621 3608 16451914 SGTC_3078 9116413 49.47 µM -0.66748507099618 0.278727698716608 no 2431 0.252231171252915 3576 17177322 SGTC_1108 betulinic acid 729.144 nM -0.667568902267121 0.278702524909659 no 2432 0.252204406885544 3639 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_228 caffeine 993.056 µM -0.667767098653161 0.27864301264839 no 2433 0.252141135728253 3617 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_2930 9013230 14.89 µM -0.669341776187188 0.278170405566807 no 2434 0.251638741723556 3604 2995857 SGTC_10 0279-0212 42.575 µM -0.670180892985716 0.277918721676252 no 2435 0.25137124127683 3643 39851 YBR002C RER2 SGTC_1884 5633444 25 µM -0.671976253917412 0.277380596429223 no 2436 0.25079940682823 3646 5724239 SGTC_1497 4476-2978 41.3 µM -0.674490759476595 0.276627778722366 no 2437 0.249999679274407 3654 1528379 SGTC_256 clotrimazole 625 nM -0.674873787850951 0.27651319182082 no 2438 0.24987797763763 3625 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_2061 5245884 80.95 µM -0.675202881737291 0.27641475856989 no 2439 0.249773438014683 3631 573863 SGTC_2264 7948757 110.76 µM -0.675554119627346 0.276309720924183 no 2440 0.249661889774162 3628 2971411 SGTC_449 xestospongin c 11.1929 µM -0.6757284193637 0.276257603881391 no 2441 0.249606544440836 3614 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_596 1155-0152 116 µM -0.676910142045657 0.275904386426263 no 2442 0.249231484407031 3643 280313 SGTC_3096 9117468 49.47 µM -0.678603335071344 0.275398677228211 no 2443 0.248694614560594 3550 41316311 SGTC_2025 5147754 141 µM -0.67879647322788 0.275341021277337 no 2444 0.248633414360697 3649 315777 YLR208W SEC13 SGTC_2139 5578692 56.4705 µM -0.679164068640697 0.275231302446133 no 2445 0.2485169555946 3593 650991 YMR113W FOL3 SGTC_1714 st033236 13.627 µM -0.681808229737063 0.27444271560473 no 2446 0.247680109865916 3684 2916566 SGTC_3015 9080845 49.47 µM -0.682496346158089 0.274237676789502 no 2447 0.247462576199973 3686 5296973 SGTC_729 4092-0585 94.1 µM -0.685894124997597 0.273226347234354 no 2448 0.246389937608391 3644 2169061 SGTC_2990 9074105 71.4286 µM -0.686883360415144 0.272932254597423 no 2449 0.246078116693771 3614 6502001 SGTC_739 1486-1183 203 µM -0.687674242225937 0.272697244041538 no 2450 0.245828971977665 3644 4346692 SGTC_1196 1588-0294 184 µM -0.688464951528333 0.272462385174694 no 2451 0.245580017026327 3645 6144269 SGTC_2344 7990960 76.95 µM -0.689019392963239 0.272297763236235 no 2452 0.245405531856125 3642 140813 SGTC_69 0096-0274 206.684 µM -0.690606578373549 0.271826777597522 no 2453 0.244906406150766 3778 6741392 SGTC_2534 helenine 20.12 µM -0.690644754935116 0.271815453976924 no 2454 0.244894407414695 3673 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_2323 6148992 148.28 µM -0.692146961710649 0.271370068069354 no 2455 0.244422521244853 3637 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.692648264953339 0.271221518766283 no 2456 0.244265156641596 3710 1377 SGTC_1058 3448-5425 97.3 µM -0.693233050859502 0.271048282602019 no 2457 0.244081654949337 3602 7279705 SGTC_2795 7780010 54.55 µM -0.693257802020795 0.271040951570005 no 2458 0.244073889849879 3655 953673 SGTC_1637 st007924 17.4 µM -0.695235475332457 0.270455505533561 no 2459 0.243453871842163 3656 683336 SGTC_2357 9067248 200 µM -0.69535779022052 0.270419317701871 no 2460 0.243415553007884 3665 9150235 SGTC_860 0443-0016 25.1 µM -0.695505442055125 0.270375636957144 no 2461 0.243369300951125 3687 5337942 SGTC_1730 st033808 45.1 µM -0.696375946908698 0.270118181894981 no 2462 0.243096711162273 3658 1045166 SGTC_609 0986-0026 86.3 µM -0.696601659771898 0.270051446499205 no 2463 0.243026058427737 3652 2848610 SGTC_2008 4012253 172 µM -0.697076227889265 0.269911160223643 no 2464 0.242877545149647 3683 603940 SGTC_1512 0259-0544 12.2 µM -0.697802362774601 0.269696579355189 no 2465 0.242650400631162 3656 18476 SGTC_744 1594-0068 283 µM -0.697806771236706 0.269695276867009 no 2466 0.242649021957725 3691 668392 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.699409759977201 0.269221879879325 no 2467 0.24214799506078 3813 16725076 SGTC_855 0428-0020 25 µM -0.700038222551145 0.269036395198311 no 2468 0.241951717240803 3687 6812414 SGTC_1780 st038448 24.544 µM -0.700584123365077 0.268875329896356 no 2469 0.24178129469942 3718 728868 YDL195W SEC31 SGTC_1871 st057448 67.3 µM -0.700863133887788 0.26879302794063 no 2470 0.241694216708869 3757 691747 SGTC_1816 st051957 91.6 µM -0.700906987417494 0.268780093266551 no 2471 0.241680531758124 3681 674121 SGTC_1051 3253-3903 78 µM -0.701399135860197 0.268634954682023 no 2472 0.241526980561865 3673 5509239 SGTC_905 2-aminofluorene 215 µM -0.701759660923964 0.268528657902671 no 2473 0.241414529725365 3705 1539 An established DNA mutagen. YPR165W RHO1 SGTC_1581 himbacine 57.9 µM -0.702940752547663 0.268180574415223 no 2474 0.241046336479292 3680 5281825 An alkaloid muscarinic receptor antagonist. SGTC_2817 7995342 71.43 µM -0.703363359414222 0.26805608170243 no 2475 0.240914667319718 3661 18879975 SGTC_441 propafenone 146 µM -0.704931644538321 0.267594346331564 no 2476 0.240426388015621 3653 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_1649 st011737 51.3 µM -0.7092234440835 0.266332805753281 no 2477 0.239092913603994 3692 1761035 SGTC_551 k048-0028 34.9 µM -0.709609397262629 0.266219505537874 no 2478 0.238973195278113 3682 6836383 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.70988083445087 0.266139837194208 no 2479 0.23888901815711 3720 5357218 A potent inhibitor of glutathione S-transferases. SGTC_3307 9126885 69.2785 µM -0.709969616625344 0.266113781746186 no 2480 0.238861488869399 3698 24824909 SGTC_3065 9113888 49.47 µM -0.711338541331375 0.265712198612393 no 2481 0.238437236859052 3736 16648368 SGTC_480 am 92016 50 µM -0.713578982728986 0.265055613873952 no 2482 0.237743778774174 3623 2129 K+ channel blocker. SGTC_50 0929-0078 56.389 µM -0.714993539126362 0.264641488243116 no 2483 0.237306517780861 3610 1377751 SGTC_3123 9126162 49.47 µM -0.715974227555143 0.264354575126574 no 2484 0.23700363142955 3783 25239884 SGTC_2429 5902844 64.44 µM -0.71607976781682 0.26432370739496 no 2485 0.236971047909414 3733 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_1012 4112-3522 18 µM -0.716283410196958 0.26426415257843 no 2486 0.23690818421205 3684 3112398 SGTC_2351 9026858 72.31 µM -0.716946863111798 0.264070174472365 no 2487 0.236703442198264 3646 1409300 SGTC_1738 st035555 74 µM -0.717940483233835 0.263779798947669 no 2488 0.23639699247792 3712 5331140 SGTC_473 2-arachidonoylglycerol 10 µM -0.718408612826139 0.263643049215277 no 2489 0.236252688896336 3628 5282280 An endocannabinoid. SGTC_872 0588-0139 234 µM -0.718698439029319 0.263558403491823 no 2490 0.236163372656873 3714 2047100 SGTC_1194 1488-0194 225 µM -0.718805651246587 0.263527094945227 no 2491 0.236130337596779 3672 1391452 SGTC_20 0481-0013 4.944 µM -0.720772355215901 0.262953107027248 no 2492 0.235524793375473 3706 182045 SGTC_710 3448-4187 58 µM -0.721186349153666 0.262832363245566 no 2493 0.235397434717997 3730 3946412 SGTC_600 1495-0418 41.6 µM -0.721332989639921 0.262789601481235 no 2494 0.235352332220109 3716 5377768 SGTC_1629 st005085 44.9 µM -0.723099700092573 0.262274691694423 no 2495 0.234809316768643 3709 24207091 SGTC_3159 9100096 49.47 µM -0.725546360999718 0.261562463979668 no 2496 0.234058457005484 3685 25236875 SGTC_2889 9059656 51.95 µM -0.725887530763222 0.261463227734142 no 2497 0.23395386060746 3794 3949838 SGTC_1867 st057372 64 µM -0.726723560892491 0.261220132925324 no 2498 0.233697658598113 3703 688837 SGTC_2174 5790901 200 µM -0.728252018410563 0.260775999519814 no 2499 0.233229664106095 3746 786020 SGTC_2468 5987765 72.9 µM -0.728364209094318 0.260743414887481 no 2500 0.233195333231975 3759 26772094 SGTC_2440 5628896 157.78 µM -0.729551394292177 0.260398737561914 no 2501 0.232832220949273 3761 5522048 SGTC_771 0250-0039 27.3 µM -0.730021140286964 0.260262420307252 no 2502 0.2326886312996 3715 3005115 SGTC_306 1672-3436 11.6 µM -0.730121173829593 0.260233395968866 no 2503 0.232658059895196 3727 6797378 SGTC_2653 dihydrofissinolide 100 µM -0.730720877972166 0.26005942915504 no 2504 0.232474830212941 3775 6857746 SGTC_2702 st077768 96.8 µM -0.731517175670474 0.259828525666797 no 2505 0.232231658690604 3667 6484119 SGTC_646 4092-0839 27.3 µM -0.733040988291328 0.259386958789435 no 2506 0.231766715200537 3769 877796 SGTC_1325 1431-0015 227 µM -0.733167080397716 0.259350437486707 no 2507 0.231728265406208 3685 1103340 SGTC_2883 9059145 45.46 µM -0.734774206396767 0.258885182540466 no 2508 0.231238509197762 3731 16476510 SGTC_1416 3966-0321 25.3 µM -0.73652747996812 0.258378111545144 no 2509 0.230704875172424 3758 582530 YLR208W SEC13 SGTC_2718 lomofungin 53.02 µM -0.73718244237293 0.258188819458681 no 2510 0.230505704585454 3735 5351222 A RNA synthesis inhibitor. SGTC_1818 st052136 56.3 µM -0.737306481697838 0.258152978686562 no 2511 0.230467995712645 3618 674169 SGTC_1402 3909-7673 35.9 µM -0.738608098999957 0.257777036083932 no 2512 0.230072502430144 3747 5328014 SGTC_3102 9121669 49.47 µM -0.738818565694264 0.257716274257727 no 2513 0.230008588317571 3752 41905072 SGTC_2340 7987427 183.45 µM -0.741925608723255 0.256820135414484 no 2514 0.229066204510943 3725 2239331 SGTC_3173 9105693 49.47 µM -0.7468910339151 0.255391372965128 no 2515 0.227564669289002 3791 17096658 SGTC_3302 9125395 16.351 µM -0.747778258061456 0.255136519263108 no 2516 0.227296959218669 3709 17599668 SGTC_3130 9127414 49.47 µM -0.74778582612897 0.255134345920203 no 2517 0.22729467640162 3757 1494646 SGTC_3011 9081274 71.4286 µM -0.748537228087212 0.25491861195208 no 2518 0.227068089314782 3752 6625322 SGTC_1768 st044301 37.178 µM -0.750359992008718 0.254395677680994 no 2519 0.22651895994342 3763 3931349 SGTC_1180 1193-0155 285 µM -0.752733989876577 0.253715443348688 no 2520 0.225804890225404 3764 2921347 SGTC_2278 7948257 134.34 µM -0.753010728257257 0.253636210222826 no 2521 0.225721733618785 3723 1247028 SGTC_1965 Pectolinarigenin 58.4 µM -0.753245811505124 0.253568913612696 no 2522 0.225651107497354 3754 5320438 An anti-inflammatory. SGTC_1123 mangostin 811.285 nM -0.754742889454165 0.253140569554489 no 2523 0.225201633439254 3788 5281650 An antioxidant. SGTC_2561 acetosyringone 100 µM -0.755527153647418 0.252916327827255 no 2524 0.224966373047631 3776 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_3161 9100388 49.47 µM -0.756959742677333 0.252506983067222 no 2525 0.224536990624767 3782 25236368 SGTC_2680 butyl paraben 22.24 µM -0.758092294707317 0.252183617453917 no 2526 0.224197866086847 3809 7184 An antifungal and steroid mimetic. SGTC_3013 9080133 71.4286 µM -0.758274204553357 0.252131699022091 no 2527 0.224143423224244 3813 17050193 SGTC_3276 9139060 49.47 µM -0.759248770854241 0.251853646545603 no 2528 0.223851878184296 3838 4870619 SGTC_3196 9111891 49.47 µM -0.759938833854479 0.251656863333394 no 2529 0.223645573735563 3776 18891510 SGTC_1857 st056007 79.3 µM -0.760479028827915 0.251502874228306 no 2530 0.223484150002774 3764 619834 SGTC_547 1120-0019 610 nM -0.760731952248533 0.251430792467896 no 2531 0.223408592962815 3702 3676939 SGTC_2778 tioconazole 65.09 nM -0.760941889066713 0.251370969942462 no 2532 0.223345888559359 3716 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_573 3702-0553 84.7 µM -0.763789924118346 0.250560152335991 no 2533 0.222496221126556 3730 1222756 SGTC_2300 7976697 71.57 µM -0.764007292589885 0.250498325866669 no 2534 0.22243144838479 3708 2236109 SGTC_3185 9108267 49.47 µM -0.765108288179512 0.250185292106281 no 2535 0.222103532453228 3731 4910486 SGTC_2704 st078022 71.1 µM -0.76517738369328 0.250165653872633 no 2536 0.222082962539863 3789 54697681 SGTC_1609 st001574 46.4 µM -0.765761466654423 0.249999679274407 no 2537 0.221909122985933 3788 3960012 SGTC_2903 5923464 63.88 µM -0.766339762400718 0.24983540677096 no 2538 0.221737082454206 3804 2876576 SGTC_457 grayanotoxin iii 135 µM -0.769539594957941 0.24892748902442 no 2539 0.22078652426629 3715 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_1433 4060-0023 7.6 µM -0.772212984431768 0.248170292336665 no 2540 0.219994146202557 3791 3840627 SGTC_2686 alizarin 95.37 µM -0.773202187912307 0.247890427257252 no 2541 0.219701365756378 3806 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_1821 st053465 65.6 µM -0.773389169064049 0.24783754555618 no 2542 0.219646048982813 3790 675086 SGTC_1673 st016611 27.3 µM -0.775193433002352 0.247327576171737 no 2543 0.219112684032184 3846 5226799 SGTC_2339 9000433 200 µM -0.775310412022096 0.247294531803719 no 2544 0.219078129169103 3814 2988954 SGTC_1667 st014849 34.6 µM -0.775959868682418 0.247111115476425 no 2545 0.21888634077879 3856 5348460 SGTC_1688 st021091 57.6 µM -0.776348631146311 0.247001357935817 no 2546 0.218771583155699 3823 3656366 SGTC_1294 1000-1494 117 µM -0.778495891010403 0.246395602009112 no 2547 0.21813836403072 3785 712797 YDL207W GLE1 SGTC_2163 5671233 125 µM -0.780332307788832 0.245878169250637 no 2548 0.217597650407611 3812 701023 SGTC_394 menadione 8.33 µM -0.780447683188237 0.245845680311004 no 2549 0.217563705177432 3752 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_2299 7976368 114.88 µM -0.780900675467961 0.245718143006251 no 2550 0.217430457389889 3853 2979718 SGTC_2750 bromebric acid 70.15 µM -0.781827659866074 0.245457266785733 no 2551 0.217157931612241 3881 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_1670 st016595 4.04 µM -0.782128500594927 0.245372634799173 no 2552 0.217069529347281 3810 597879 SGTC_1950 st077106 7.18 µM -0.782258797798391 0.245335984686018 no 2553 0.217031247874655 3828 13831864 SGTC_1446 4239-0190 62 µM -0.783026840152094 0.245120008853133 no 2554 0.216805675412805 3810 1340085 SGTC_1564 D-Arginine 115 µM -0.784407885018524 0.244731912243486 no 2555 0.216400406582606 3803 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_2316 5844804 197.44 µM -0.785031205920458 0.244556857100922 no 2556 0.216217636212707 3875 776813 SGTC_736 0958-0254 92.6 µM -0.785670529686191 0.244377377759757 no 2557 0.216030266363056 3874 6812352 SGTC_254 nsc-64875 3.808 µM -0.785847396787976 0.24432773784842 no 2558 0.21597844764143 3854 56993 SGTC_2007 4011539 71.82 µM -0.786791657212875 0.244062811615654 no 2559 0.215701919040363 3807 45595301 SGTC_3138 9097216 49.47 µM -0.788435819336863 0.243601887612683 no 2560 0.21522091296054 3805 25237486 SGTC_718 1130-0073 349 µM -0.789078145711635 0.243421945776917 no 2561 0.215033167104636 3853 6740020 SGTC_611 3453-1652 23.7 µM -0.789366553687153 0.243341174298959 no 2562 0.214948899157726 3783 1560575 SGTC_2142 5622915 118.518 µM -0.789549660358853 0.243289901000266 no 2563 0.214895408431175 3836 5322196 SGTC_1831 st055328 12 µM -0.789985302775387 0.243167936437881 no 2564 0.214768175833687 3790 1103068 SGTC_2072 5231554 129 µM -0.791880536406496 0.24263772259723 no 2565 0.214215168442411 3865 789545 SGTC_2695 st077686 51.995 µM -0.794570947560072 0.241886124790419 no 2566 0.213431561831828 3883 2876092 SGTC_2897 9048598 12.99 µM -0.794808261921639 0.24181988892507 no 2567 0.213362522155104 3808 6467404 SGTC_389 tpck 16.7 µM -0.796011667655156 0.24148416269362 no 2568 0.213012626890472 3849 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_3345 9148410 3.559 µM -0.796327387590662 0.241396125058124 no 2569 0.212920885463141 3782 4903596 SGTC_1097 itavastatin 7.23 µM -0.79632969499338 0.24139548170941 no 2570 0.212920215066391 3830 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_2658 polymyxin b sulfate 77.05 µM -0.796473451823116 0.241355401348746 no 2571 0.212878450139273 3841 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_2360 9040895 200 µM -0.797424122632668 0.241090439039071 no 2572 0.212602377057678 3858 4914414 SGTC_2487 5918373 44.05 µM -0.798186106864104 0.240878179967289 no 2573 0.212381249256718 3838 2876279 SGTC_942 3253-1115 227 µM -0.798937964858245 0.240668841353448 no 2574 0.21216319187125 3881 46497897 SGTC_3326 9140064 16.379 µM -0.801188793358281 0.240042739178886 no 2575 0.211511178978956 3798 1868434 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.80153354034922 0.239946921048077 no 2576 0.211411417473349 3855 6710655 SGTC_2635 hydroquinidine 100 µM -0.802038405587181 0.239806637693802 no 2577 0.211265371329152 3784 442912 An experimental heart treatment. SGTC_1513 0337-0559 19 µM -0.803997366398825 0.23926273890473 no 2578 0.210699247994126 3822 775073 SGTC_1697 st025554 27.742 µM -0.806407601048611 0.238594471260942 no 2579 0.210003932807581 3808 1269519 SGTC_727 3032-0951 202 µM -0.806824666997712 0.238478938287702 no 2580 0.20988375275805 3840 3652836 SGTC_1289 0976-0073 69.1 µM -0.809580735668277 0.237716240050531 no 2581 0.209090591857294 3906 3391136 SGTC_3203 9113543 49.47 µM -0.810780006355182 0.237384779223791 no 2582 0.208746009122897 3947 17018012 SGTC_2244 6635614 200 µM -0.811167224672807 0.23727781198026 no 2583 0.208634822394658 3766 836499 SGTC_1029 k015-0030 64.7 µM -0.811695944993531 0.237131798232843 no 2584 0.208483060857849 3933 2208316 SGTC_2100 5377183 190 µM -0.814140213955018 0.236457420162938 no 2585 0.207782315304587 3876 2844202 SGTC_870 0573-2213 57.6 µM -0.814508143475019 0.236355999251992 no 2586 0.207676954475239 3846 3916321 SGTC_2377 9073351 62.6 µM -0.816181406115041 0.235895061486874 no 2587 0.207198194894193 3834 7337946 YHR072W ERG7 SGTC_1215 3852-0577 11.2 µM -0.816550146935893 0.235793550216679 no 2588 0.207092777364399 3929 2884876 SGTC_1727 st034309 9.9045 µM -0.817368581138136 0.235568328189562 no 2589 0.206858912566497 3984 870305 SGTC_2219 9098279 200 µM -0.821266621713435 0.23449727052197 no 2590 0.205747207866542 3818 902349 SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.825059411382236 0.233457723583833 no 2591 0.204668930856252 3954 688801 SGTC_3328 9140624 29.0385 µM -0.825594000641966 0.233311406485841 no 2592 0.204517219750795 3904 4904392 SGTC_1689 st020265 53.493 µM -0.82681531206575 0.232977324513793 no 2593 0.204170874927499 3836 5758320 YPR016C TIF6 SGTC_828 2074-0507 139 µM -0.827154307745261 0.232884641531732 no 2594 0.204074803025539 3954 X828 SGTC_2985 9022375 71.43 µM -0.827274437073197 0.232851802535503 no 2595 0.204040764650938 3897 4939335 SGTC_937 3122-0005 46.7 µM -0.827356058803193 0.232829491586207 no 2596 0.204017639247425 3927 759535 SGTC_763 3453-1109 128 µM -0.827484699595861 0.232794330589362 no 2597 0.203981195380224 3890 1560353 SGTC_2924 9010168 62.78 µM -0.82891874281114 0.232402567752581 no 2598 0.203575194409208 3975 2993929 SGTC_1005 4092-0690 4.4 µM -0.829820437161535 0.232156423929783 no 2599 0.203320157034269 3911 1529343 SGTC_2512 diallyl trisulfide 49.23 µM -0.82983569752293 0.232152259417161 no 2600 0.2033158423987 3896 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_3145 9085516 49.47 µM -0.833604520110529 0.231125031668986 no 2601 0.2022519388295 3944 25236195 SGTC_976 1348-1067 47.6 µM -0.838638864878246 0.229756839746838 no 2602 0.200835997176519 3922 5310671 YGL099W LSG1 SGTC_751 0833-0568 350 µM -0.839609773243863 0.2294934971046 no 2603 0.200563608845294 3959 6954252 SGTC_3258 9138477 49.47 µM -0.839650172804178 0.229482543066707 no 2604 0.200552279558523 3929 4970355 SGTC_1554 st069299 38.7 µM -0.840916010308892 0.229139469168596 no 2605 0.200197494246613 3838 24207999 SGTC_1822 st052468 42 µM -0.840922638124035 0.229137673620847 no 2606 0.200195637614748 3901 2873678 SGTC_2875 9039966 71.43 µM -0.841490990056656 0.228983730210683 no 2607 0.200036465223373 3930 6463691 SGTC_2683 piperine 63.03 µM -0.841754699930999 0.228912321651253 no 2608 0.199962636600711 3852 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_2735 sertaconazole 140 nM -0.844663842420127 0.228125400671939 no 2609 0.199149276396651 3991 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_2812 7970281 58.44 µM -0.845422352754396 0.227920474455093 no 2610 0.19893753430932 3945 2233435 SGTC_2389 9091542 195.52 µM -0.846621379855379 0.227596745479146 no 2611 0.198603096577781 3889 3626624 YOL127W RPL25 SGTC_1297 1068-0111 14.1 µM -0.849206519085309 0.226899657474793 no 2612 0.197883193202587 3856 767057 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.849286762328944 0.226878039010173 no 2613 0.197860872511374 3880 803109 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.849967145397831 0.226694782582816 no 2614 0.197671676333062 3947 23847180 SGTC_2754 granisetron 64.02 µM -0.850059784120799 0.226669837452583 no 2615 0.197645924462944 3904 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_2097 5376186 200 µM -0.851580849837048 0.226260476744265 no 2616 0.197223386062386 3846 742755 SGTC_787 4152-0075 138 µM -0.852039734925115 0.226137060177047 no 2617 0.19709601928906 3936 9566539 SGTC_3026 9090633 49.47 µM -0.855482232592372 0.225212418875568 no 2618 0.196142118208232 3915 25236842 SGTC_3343 9148379 18.9835 µM -0.856331856550718 0.224984543158503 no 2619 0.195907122588642 3973 1955036 SGTC_2732 terfenadine 20 µM -0.856840500774215 0.224848183400586 no 2620 0.195766519587581 3914 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_684 1140-0066 328 µM -0.85714591115267 0.224766330054875 no 2621 0.195682125346672 3971 6813534 SGTC_711 k292-0785 179 µM -0.857821667587822 0.224585279954 no 2622 0.195495471662171 3889 4146315 SGTC_3112 9123419 49.47 µM -0.857915395955178 0.22456017458571 no 2623 0.195469591075253 3941 17015854 SGTC_2771 fluoxetine 41.05 µM -0.858684665301658 0.224354184114728 no 2624 0.1952572565134 3879 3386 A selective serotonin reuptake inhibitor. SGTC_2333 9017922 200 µM -0.85968982404777 0.224085190258978 no 2625 0.194980022806019 3974 3163164 SGTC_2238 6671620 73.2395 µM -0.860370905451469 0.223903027979742 no 2626 0.194792309246351 3867 729941 SGTC_2973 9094665 17.96 µM -0.862266226418736 0.223396547914458 no 2627 0.194270516708828 3990 25237061 YIL048W NEO1 SGTC_754 3474-0146 171 µM -0.86350364625673 0.223066228528506 no 2628 0.193930307768655 3901 24762078 SGTC_237 nikkomycin 200 µM -0.864569691006264 0.222781879513074 no 2629 0.193637507015248 3911 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_2181 6316240 54.2555 µM -0.864990376590351 0.222669725766129 no 2630 0.19352203537798 3955 12779990 SGTC_316 k060-0003 58.6 µM -0.865622279195038 0.222501322570703 no 2631 0.193348666907299 3929 6152314 SGTC_277 nystatin 15.5 µM -0.868670036098258 0.221690110431728 no 2632 0.192513817549384 3906 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_405 ebelactone b 50 µM -0.869123212498778 0.221569634338735 no 2633 0.192389870773385 3897 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_525 k781-2675 26.7 µM -0.869140617596911 0.221565007972483 no 2634 0.192385111335912 3907 3651118 YDL195W SEC31 SGTC_2195 6536160 144.242 µM -0.869611568528962 0.221439847707978 no 2635 0.192256356772963 3851 3834386 SGTC_1225 1216-0074 20.6 µM -0.869924499085527 0.221356705412243 no 2636 0.192170832985653 3935 4241466 SGTC_1684 st024538 14.6195 µM -0.87013894263012 0.221299740369764 no 2637 0.192112239098459 3903 6732859 SGTC_1702 st027038 51 µM -0.870302372976836 0.221256332165169 no 2638 0.192067591239457 3961 5521182 SGTC_862 0452-0056 10.2 µM -0.870360662350682 0.221240851291897 no 2639 0.19205166858663 3898 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_675 1309-0189 238 µM -0.870493438846269 0.221205589954689 no 2640 0.192015401628887 3955 4246530 SGTC_3222 9128301 49.47 µM -0.871053560265499 0.221056874394295 no 2641 0.191862454576273 3963 4911358 SGTC_979 1426-2828 121 µM -0.871451450317759 0.220951266991599 no 2642 0.191753851827547 4041 747872 SGTC_642 0335-0876 158 µM -0.871499502951622 0.22093851488575 no 2643 0.191740738571081 3955 6812350 SGTC_873 0591-4978 488 µM -0.87267781785899 0.22062594803534 no 2644 0.191419355818207 4016 3305145 SGTC_1268 0828-0275 2.46 µM -0.872993684590204 0.220542202414919 no 2645 0.191333260009623 3989 745337 SGTC_949 1165-0505 146 µM -0.87346736588314 0.220416649627247 no 2646 0.19120419316994 3966 6244267 SGTC_1208 2323-2347 50.3 µM -0.873487351211161 0.22041135326667 no 2647 0.19119874881912 3940 5412760 SGTC_2112 5488546 200 µM -0.874100675308076 0.220248850222817 no 2648 0.191031714887234 3898 600757 SGTC_144 4161-2749 112.381 µM -0.874601971164068 0.220116080614294 no 2649 0.190895257442774 3840 797501 YMR168C CEP3 SGTC_1928 4'-methoxychalcone 40.3 µM -0.87535131021463 0.219917701697257 no 2650 0.190691391842914 3993 641818 SGTC_779 1360-0071 233 µM -0.876694570655305 0.219562345834434 no 2651 0.190326278273049 4007 7566 SGTC_2099 5377090 177.372 µM -0.878018702439094 0.219212373414033 no 2652 0.189966784670261 3973 2243829 SGTC_647 0140-0236 81 µM -0.880253530698116 0.21862242882885 no 2653 0.189360990105653 3949 990837 SGTC_3047 9092122 49.47 µM -0.880541494667731 0.218546479320436 no 2654 0.189283018327501 3940 17173831 SGTC_172 1112-0046 2.638 µM -0.881435938540576 0.218310669720099 no 2655 0.189040956530283 3913 2802135 YIL048W NEO1 SGTC_428 3448-4153 16.5 µM -0.881463679927801 0.218303358374247 no 2656 0.189033451976514 3908 3834874 SGTC_1285 0929-0069 65.5 µM -0.881851648853095 0.218201122502916 no 2657 0.188928518499852 3968 1206237 SGTC_2276 7947513 42.08 µM -0.882072907684118 0.218142829701645 no 2658 0.188868690969218 3912 2105100 SGTC_3275 9138069 49.47 µM -0.882152880220333 0.218121762363964 no 2659 0.188847069577837 4040 17617007 SGTC_1166 k206-0078 225 µM -0.88218873064989 0.21811231858868 no 2660 0.188837377543451 3971 5404595 SGTC_2236 dapsone 200 µM -0.883723084549485 0.217708357662844 no 2661 0.188422857828403 3946 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_1345 1488-0192 31.4 µM -0.884090622129045 0.217611657392982 no 2662 0.188323647574629 3965 658348 SGTC_1524 corynanthine 62.1 µM -0.88409421733261 0.217610711606275 no 2663 0.188322677272344 4085 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_1245 0418-0076 17.2 µM -0.885025726931139 0.217365740223032 no 2664 0.188071377941656 4003 6790114 SGTC_2598 perillyl alcohol 100 µM -0.88627297995544 0.217037983096544 no 2665 0.187735222762624 3985 10819 An apoptosis inducer. SGTC_532 1548-0774 215 µM -0.88639396549139 0.217006205333905 no 2666 0.187702634931017 4104 5932993 SGTC_2317 5986382 200 µM -0.891942414666861 0.215551755134216 no 2667 0.186211899428578 3979 877883 SGTC_2283 7944793 200 µM -0.892514660547183 0.215402070969132 no 2668 0.186058569140222 3998 2970533 SGTC_1195 1502-0147 41.1 µM -0.89440670782036 0.214907591691631 no 2669 0.185552162403078 3938 817940 SGTC_2928 9011484 9.79 µM -0.897218058298855 0.214174075060588 no 2670 0.184801285495881 3996 2994751 SGTC_749 1000-0129 128 µM -0.89819499847839 0.213919520562805 no 2671 0.184540799689157 4025 708470 SGTC_2202 7226349 200 µM -0.898374665717204 0.213872725105159 no 2672 0.184492919103448 3917 844334 SGTC_1903 st060211 78.3 µM -0.899901748675202 0.213475227477493 no 2673 0.184086269730936 4018 688960 SGTC_354 2783-3500 4.88 µM -0.900080958852156 0.213428607557207 no 2674 0.184038584175162 3981 6740761 SGTC_1431 4049-0260 9.09 µM -0.900300889935477 0.213371402569331 no 2675 0.183980073813799 3951 3854841 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.902036567714245 0.212920259291278 no 2676 0.183518721416173 3994 115019 SGTC_2865 9030313 51.95 µM -0.905264294167197 0.212082779387054 no 2677 0.182662693814691 3920 42562754 SGTC_1981 st071826 47 µM -0.905958616583481 0.21190287954258 no 2678 0.182478878443109 4000 11838600 SGTC_345 1362-0200 395 µM -0.907121687766701 0.211601726377094 no 2679 0.182171225207534 3975 1419823 SGTC_1048 3161-0300 24.5 µM -0.90769157195355 0.211454258188881 no 2680 0.182020599014064 3966 2165101 SGTC_266 formosanin C 406 nM -0.908514888554171 0.211241315941335 no 2681 0.181803125614747 3884 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_2690 usnic acid 100 µM -0.908825479031761 0.211161017605196 no 2682 0.181721127523725 3988 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1664 st014217 9.02 µM -0.909140287110264 0.211079647129826 no 2683 0.181638039572193 4010 3982782 SGTC_153 4077-0274 519.67 µM -0.910313589978408 0.210776537904554 no 2684 0.181328576763081 3982 3121976 SGTC_57 miconazole 162.5 nM -0.910507405470594 0.210726492494539 no 2685 0.181277489027272 3917 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_1757 st041620 31.8375 µM -0.910747929372198 0.21066439612444 no 2686 0.181214101978685 4067 5289815 SGTC_768 0384-0033 77.3 µM -0.910805037371067 0.21064965405495 no 2687 0.181199053923525 3973 3965305 YMR134W ERG29 SGTC_2166 5933061 31.504 µM -0.911577255090369 0.21045037035961 no 2688 0.180995650088064 4060 2877375 SGTC_1824 st053723 68.6 µM -0.911822389551299 0.210387132461027 no 2689 0.180931111064104 4025 675225 SGTC_899 1083-0020 478 µM -0.911882693877354 0.210371577325769 no 2690 0.180915236346098 4049 767123 SGTC_2872 9044037 25.97 µM -0.91349556490836 0.209955797605456 no 2691 0.180490982553255 3978 6465195 SGTC_2804 7954240 19.48 µM -0.915614508898134 0.209410292679294 no 2692 0.179934559382099 4039 828705 SGTC_392 N-ethylmaleimide 8.33 µM -0.916209875040074 0.209257170713136 no 2693 0.179778413537215 3936 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_19 0279-0214 38.434 µM -0.918456010664559 0.208680081682043 no 2694 0.179190089377614 4044 3566274 YBR002C RER2 SGTC_1264 0783-0040 158 µM -0.919729579918451 0.208353286692582 no 2695 0.178857045466392 3892 2855798 SGTC_1883 5-benzylidenerhodanine 20 µM -0.922606388885464 0.207616216037291 no 2696 0.178106182514131 3998 1273210 SGTC_2539 epi(13)torulosol 80 µM -0.923004002127504 0.207514464400425 no 2697 0.178002559802447 4045 6708597 SGTC_928 2764-0428 58.7 µM -0.923061251498362 0.207499816367338 no 2698 0.177987643070913 4031 662578 SGTC_2394 5221648 200 µM -0.923699589886886 0.207336530175952 no 2699 0.177821372850962 4071 788586 SGTC_2992 9074591 71.4286 µM -0.925309258848269 0.206925116275909 no 2700 0.177402531982646 3951 17741321 SGTC_1156 4092-0367 4.88 µM -0.925522391953264 0.206870678013759 no 2701 0.177347120817067 4008 1357585 SGTC_3256 9138902 49.47 µM -0.925676050609147 0.206831435920142 no 2702 0.177307178827945 4057 17228773 SGTC_2470 5664817 21.68 µM -0.925899383711643 0.206774407885243 no 2703 0.177249135810949 4020 2859561 SGTC_2035 5154463 94.595 µM -0.926974080255938 0.206500114678515 no 2704 0.176969996056859 4029 2769623 SGTC_2446 5162541 200 µM -0.927415191419076 0.206387592952479 no 2705 0.17685550308573 3977 1549321 SGTC_2583 asiatic acid 100 µM -0.927518662633695 0.206361204051698 no 2706 0.176828653309932 4016 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_1563 conessine 56.1 µM -0.928195736001299 0.206188575218018 no 2707 0.176653022940717 4076 441082 An anti-amoebic, histamine inhibitor. SGTC_2477 5967686 25.23 µM -0.929203471605346 0.205931798256544 no 2708 0.176391824324244 3995 776118 SGTC_1321 1326-2144 215 µM -0.934089824910679 0.204689419018788 no 2709 0.175128780076264 4021 3513030 SGTC_2904 7225135 42.03 µM -0.934614698423503 0.204556233067737 no 2710 0.174993450691146 4115 4446116 SGTC_565 1418-0001 44.5 µM -0.939246496195603 0.203383157635651 no 2711 0.173802100872167 4095 2862145 SGTC_1253 0550-0034 176 µM -0.939769713095066 0.203250897532914 no 2712 0.173667848711726 4056 5969915 SGTC_1408 3909-7976 48.8 µM -0.94015081096229 0.203154594961145 no 2713 0.173570104397519 4057 24152374 SGTC_463 ikarugamyin 104 µM -0.940185403334786 0.203145854895273 no 2714 0.173561233848934 4095 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_1949 st076024 69.1 µM -0.940316697435053 0.203112684333811 no 2715 0.173527568627657 3939 2921930 SGTC_1470 k295-0292 231 µM -0.942637410107371 0.202526905939121 no 2716 0.172933198923252 4093 5045612 SGTC_662 k832-1615 104 µM -0.944779900168641 0.201987010878296 no 2717 0.172385627752988 4056 5878478 SGTC_2529 gangaleoidin 93.61 µM -0.947178998212741 0.201383475623345 no 2718 0.171773787628933 4051 4565183 SGTC_1230 0170-0365 3.77 µM -0.948179501433505 0.20113210116901 no 2719 0.171519040384461 4082 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_2955 9076254 12.21 µM -0.949338846986271 0.200841053371491 no 2720 0.171224150969324 3964 16459619 SGTC_3192 9110362 49.47 µM -0.950076191442187 0.200656078357721 no 2721 0.171036769883123 4054 16649480 SGTC_3005 9076496 71.4286 µM -0.95099317460236 0.20042618075773 no 2722 0.170803920346443 4021 21368410 SGTC_2328 6201408 200 µM -0.952441102943055 0.200063491770391 no 2723 0.17043666117586 4044 2890418 SGTC_78 0336-0123 156.75 µM -0.952935779436487 0.199939671617879 no 2724 0.170311305157844 3860 6765896 SGTC_2067 5224629 34.075 µM -0.952956650694481 0.199934448444533 no 2725 0.170306017469209 4045 2835000 SGTC_2857 9024691 58.44 µM -0.954640243970403 0.199513388158346 no 2726 0.169879829129702 4144 16478292 SGTC_2807 7945238 51.95 µM -0.954827466116989 0.199466597609682 no 2727 0.169832477607777 4090 17148797 SGTC_3187 9109394 49.47 µM -0.955811567260001 0.199220759738387 no 2728 0.169583721618518 4050 17098090 SGTC_2520 obtusaquinone 4.71 µM -0.956903498818818 0.198948198483282 no 2729 0.169307982532988 4091 5967872 SGTC_1023 4482-3888 16 µM -0.957940095725036 0.198689657575482 no 2730 0.169046483225487 4075 3303168 SGTC_641 4092-0595 30 µM -0.957985611946523 0.198678309876249 no 2731 0.16903500692788 4067 786260 SGTC_3163 9099914 49.47 µM -0.958454169052013 0.198561516110135 no 2732 0.168916895702193 4038 16268368 SGTC_777 1315-0167 517 µM -0.959764905257756 0.198235018616189 no 2733 0.16858677440427 4067 4221767 SGTC_1091 telmisartan 47.6 µM -0.960546080198514 0.198040586261402 no 2734 0.168390225495427 4094 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_2125 5246583 200 µM -0.960685807981264 0.198005820535479 no 2735 0.168355084581465 4030 835267 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.963571303924388 0.197288703392368 no 2736 0.167630449762394 3987 5711223 A potent inhibitor of glutathione S-transferases. SGTC_2287 7945887 168.79 µM -0.965057739322467 0.196919901315455 no 2737 0.167257946277033 4067 1245853 SGTC_953 1188-0045 9.7 µM -0.966761493600699 0.196497693627417 no 2738 0.166831639057407 4082 6144426 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.969973556360586 0.195703205110258 no 2739 0.166029836634228 4066 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1442 4112-3290 3 µM -0.971627427601623 0.195294889493377 no 2740 0.165617966254244 4026 704353 SGTC_64 000l-0018 272.079 µM -0.972084682573619 0.195182091606203 no 2741 0.165504210854007 3989 6811119 SGTC_1077 5-fluorocytosine 377 nM -0.972821408821284 0.195000435690281 no 2742 0.165321035230436 4087 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1516 st013856 110 µM -0.973659516220161 0.194793907068104 no 2743 0.165112812313986 4105 5281404 A mutagen and neurotoxin. SGTC_1211 1056-0033 32.3 µM -0.973995167789287 0.194711232254498 no 2744 0.165029469262036 4111 6741922 SGTC_201 4262-0159 12.803 µM -0.974017062427409 0.194705840096911 no 2745 0.1650240337198 4091 1341029 SGTC_1365 1672-3266 55.4 µM -0.974864063511792 0.194497312495571 no 2746 0.164813847008986 4108 6415873 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.976205886124372 0.194167240582748 no 2747 0.164481223466634 4062 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_190 3970-0790 3.722 µM -0.976958244345157 0.193982319057669 no 2748 0.164294912383134 3960 2832352 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -0.978178020097384 0.193682739479721 no 2749 0.163993142711808 4055 364106 SGTC_1693 xanthone 101.9 µM -0.978195320620446 0.193678492463616 no 2750 0.16398886519087 4107 7020 An insecticide. SGTC_1295 1013-0063 9.78 µM -0.979167563722757 0.193439912793704 no 2751 0.163748596303329 4080 6826038 SGTC_387 norethindrone acetate 66.7 µM -0.979929442167947 0.19325308006762 no 2752 0.163560474272348 4070 541197 SGTC_2496 diffractaic acid 79.83 µM -0.980019572392691 0.193230985042347 no 2753 0.163538228721751 4095 94870 An apoptosis inducer which activates caspases. SGTC_3179 9107801 49.47 µM -0.982362635779324 0.192657134607093 no 2754 0.162960613489611 4070 4818259 SGTC_1286 0929-0070 131 µM -0.985885452646658 0.191796307855747 no 2755 0.162094663136217 4164 1420408 SGTC_3156 9099931 49.47 µM -0.987951820062432 0.191292473048531 no 2756 0.161588122404811 4096 18111053 SGTC_2135 5326629 150.42 µM -0.989425510869263 0.190933644489551 no 2757 0.16122749903666 4036 5020077 SGTC_1032 k061-1018 98.7 µM -0.989494696188316 0.190916808728995 no 2758 0.161210581774905 4186 4005393 SGTC_429 1112-0049 25.5 µM -0.989912187413181 0.190815234506523 no 2759 0.161108520992568 4036 2836170 SGTC_2719 novobiocin 32.65 µM -0.990359969606164 0.190706327454805 no 2760 0.160999102087985 4087 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_858 0438-0351 2.77 µM -0.993003711055247 0.19006410942765 no 2761 0.160354072986635 4054 2799119 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.993040515073522 0.190055178381524 no 2762 0.160345105351141 4213 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_2070 5230947 200 µM -0.993581209008798 0.189924000632393 no 2763 0.160213398106987 4152 2835538 SGTC_1003 4049-0218 100 µM -0.994783118491976 0.189632604835221 no 2764 0.159920879234527 4121 295161 SGTC_3092 9117248 49.47 µM -0.998360920859589 0.188766817083588 no 2765 0.159052188135367 4176 17141857 SGTC_569 4130-2812 160 µM -1.00095108801649 0.188141548716562 no 2766 0.158425227914545 3894 743552 SGTC_155 k072-0202 43.6 µM -1.00165700142468 0.187971362567013 no 2767 0.158254640279955 3994 5857737 SGTC_1770 st043884 66.3 µM -1.00287930930792 0.187676905556978 no 2768 0.157959548390439 4085 670149 SGTC_3077 9117319 49.47 µM -1.0041614609387 0.18736833844636 no 2769 0.157650397402142 4065 17154678 SGTC_2678 equilin 100 µM -1.00495343968444 0.187177894844801 no 2770 0.157459635095194 4106 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_962 1254-0300 21.5 µM -1.00615971783067 0.186888056628248 no 2771 0.157169372957732 4078 7340576 SGTC_2012 4023501 200 µM -1.00719159492482 0.186640343112196 no 2772 0.156921355689686 4125 3477460 SGTC_1836 st055642 81 µM -1.00825598475322 0.186385037657186 no 2773 0.15666579374324 4105 8571 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -1.00947657261323 0.186092532844186 no 2774 0.15637306577026 4126 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_1178 0988-0033 191 µM -1.01032289221733 0.185889885781839 no 2775 0.15617030844872 4154 5392207 SGTC_1278 0874-0585 172 µM -1.0115830818713 0.185588393280084 no 2776 0.155868719194913 4159 766306 SGTC_2800 7887935 81.82 µM -1.01291780393123 0.185269400455541 no 2777 0.155549711781072 4119 2961002 SGTC_2355 9061122 103.12 µM -1.01524328890158 0.184714433502873 no 2778 0.154994935086009 4126 5302957 SGTC_3109 9122853 49.47 µM -1.01631117474299 0.184459933783425 no 2779 0.154740614429073 4146 1234709 SGTC_1016 4226-1401 38 µM -1.0175856191161 0.184156492441496 no 2780 0.154437462218375 4071 2901613 SGTC_1902 st060212 70.5 µM -1.01921095735168 0.183769955417967 no 2781 0.15405141289108 4105 688944 SGTC_692 k241-0027 77.8 µM -1.01982416035204 0.183624255231138 no 2782 0.153905931311037 4171 3600480 SGTC_1130 3454-2858 15.9 µM -1.02046552449041 0.183471940853684 no 2783 0.153753865850139 4148 715628 YIL048W NEO1 SGTC_2376 9072922 81.32 µM -1.02142036296075 0.183245326965142 no 2784 0.153527660909263 4137 17087968 SGTC_904 1141-0088 396 µM -1.02244797922251 0.1830016356773 no 2785 0.153284460986179 4117 1378119 SGTC_1192 1488-0095 21.4 µM -1.02258767975934 0.182968522390554 no 2786 0.153251418598246 4166 915875 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -1.02452845222049 0.182508886975537 no 2787 0.152792869548038 4102 390807 SGTC_2023 5144124 124 µM -1.02523581193303 0.182341541635811 no 2788 0.152625967166601 4096 2830192 SGTC_1814 st052110 31.539 µM -1.02627168669542 0.182096650119173 no 2789 0.152381769593908 4069 674163 SGTC_3340 9146634 11.102 µM -1.02705108301978 0.181912528378108 no 2790 0.152198205416775 4137 4907387 SGTC_349 k015-0014 24 µM -1.02719413488711 0.181878746977773 no 2791 0.152164529656023 4099 2196908 SGTC_856 0433-0016 11.3 µM -1.02780466527593 0.181734615609437 no 2792 0.152020860658076 4166 3911780 SGTC_2210 7115885 190.385 µM -1.03166383299483 0.180825214227277 no 2793 0.1511148129028 4197 2927039 SGTC_884 0851-0618 334 µM -1.03308243661483 0.180491642753557 no 2794 0.150782660925159 4146 9642473 SGTC_704 1310-0270 142 µM -1.0353399069445 0.179961615987145 no 2795 0.150255099528758 4139 5718033 SGTC_1881 5652484 16 µM -1.03581467148546 0.179850271525585 no 2796 0.150144305787663 4121 2255129 SGTC_2223 6903751 107.57 µM -1.0362640254421 0.179744926365889 no 2797 0.150039492180695 4106 5598863 SGTC_2239 6685329 187.64 µM -1.03735951819637 0.179488264912329 no 2798 0.149784168598532 4186 805680 SGTC_2134 5324836 1.464 µM -1.0391147372933 0.179077517626335 no 2799 0.149375688873743 4093 699272 SGTC_3243 9134147 49.47 µM -1.03992825038218 0.178887344226426 no 2800 0.149186618174145 4196 24282180 SGTC_334 1502-1024 68.5 µM -1.04086925246458 0.178667526579757 no 2801 0.14896811685727 4148 3296216 SGTC_2303 7774051 200 µM -1.04293837824254 0.178184778233558 no 2802 0.148488416732119 4187 2953184 SGTC_883 0850-0245 24.6 µM -1.04437610676445 0.177849825939617 no 2803 0.148155706816401 4209 6823229 YPR165W RHO1 SGTC_2971 9092186 9.93 µM -1.04663862357443 0.17732352486646 no 2804 0.147633140568152 4155 25236400 SGTC_2294 7971431 200 µM -1.04800672415181 0.177005758311373 no 2805 0.147317754437503 4130 5741572 SGTC_2676 harmalol 100 µM -1.04989940838982 0.176566741143697 no 2806 0.146882181811786 4088 5459187 A monoamine oxidase inhibitor SGTC_165 k038-0023 64.381 µM -1.05028245603298 0.176477975266925 no 2807 0.146794134406966 4151 46368543 SGTC_1326 1431-2094 10.8 µM -1.05269053135469 0.175920584554986 no 2808 0.146241424847392 4118 616278 SGTC_1784 st039334 36.3 µM -1.05928996611577 0.174398753074749 no 2809 0.144733871591805 4215 3496984 SGTC_1740 st038286 13.222 µM -1.06164086624126 0.173858661159943 no 2810 0.144199377000123 4214 716786 SGTC_2137 5261020 140 µM -1.06268243185316 0.173619714005379 no 2811 0.143962995259208 4113 763655 SGTC_3046 9092212 49.47 µM -1.06357359300653 0.1734154373243 no 2812 0.143760955164815 4214 25236637 SGTC_3239 9133757 49.47 µM -1.06395686794162 0.173327628082079 no 2813 0.143674119639769 4180 17036923 SGTC_2703 st077852 53.4 µM -1.06538919933963 0.172999728010824 no 2814 0.143349921170454 4209 6281836 SGTC_1020 4335-0961 93.3 µM -1.06789446318228 0.172427155003732 no 2815 0.142784060185117 4103 669075 SGTC_1999 st074831 12.5 µM -1.06987938911448 0.171974363417776 no 2816 0.142336800785599 4127 17112523 SGTC_2457 5731572 11.68 µM -1.07043851151937 0.171846956306986 no 2817 0.142210986134666 4204 2865357 SGTC_2654 protoveratrine a 100 µM -1.07234063131312 0.17141397212504 no 2818 0.14178353161055 4158 5702278 A heart drug and vasodilator. SGTC_261 5-fluorouridine 15.376 µM -1.07527669621697 0.170746998627012 no 2819 0.141125433190758 4202 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_989 1501-0895 10.3 µM -1.07615091751487 0.170548726802034 no 2820 0.140929883421835 4139 2830112 SGTC_3115 9123671 49.47 µM -1.07686307690506 0.170387319329961 no 2821 0.140770720306079 4288 3286988 SGTC_1386 3228-0095 33.8 µM -1.07695019728585 0.170367580636954 no 2822 0.140751257828916 4185 870181 SGTC_1439 4092-1168 46 µM -1.07763843434895 0.170211699612725 no 2823 0.140597571562163 4175 2886240 SGTC_1418 3966-3099 2.4 µM -1.07782454130699 0.170169563351463 no 2824 0.14055603265796 4177 740335 SGTC_2001 4023502 57.655 µM -1.07845738951504 0.170026330933013 no 2825 0.140414843844866 4213 108941 YCR052W RSC6 SGTC_2961 9083290 32.55 µM -1.07871003119796 0.169969172175985 no 2826 0.140358506238901 4109 17741490 SGTC_1979 st071809 45.3 µM -1.07967850633649 0.169750174264553 no 2827 0.140142684205033 4265 4976333 SGTC_2940 9060638 45.86 µM -1.08116019109558 0.169415476428995 no 2828 0.139812931311127 4168 4027022 SGTC_484 loperamide 105 µM -1.08584493417663 0.168360028240053 no 2829 0.138773801336861 4185 3955 An opioid-receptor agonist. SGTC_2382 9035899 200 µM -1.08815536960311 0.167841059660819 no 2830 0.138263261778451 4174 6462679 SGTC_1039 k821-0043 94 µM -1.08899359921168 0.167653031922994 no 2831 0.138078354162518 4195 15992768 SGTC_3234 9132280 49.47 µM -1.0903230178028 0.167355101291291 no 2832 0.13778543963777 4217 17612295 SGTC_1037 k284-1091 78.7 µM -1.09280031482924 0.166800835139107 no 2833 0.137240741690319 4163 3334711 SGTC_2280 7785178 200 µM -1.09349995631653 0.166644513275529 no 2834 0.137087174083687 4172 2954328 SGTC_320 4092-0846 5.34 µM -1.09478456411344 0.166357737833286 no 2835 0.136805515237895 4137 1359356 SGTC_3099 9120367 49.47 µM -1.09524199534211 0.166255698015915 no 2836 0.136705315960128 4222 24824940 SGTC_154 3389-1638 511.116 µM -1.09544289620876 0.166210895559874 no 2837 0.136661324940398 4186 5238686 SGTC_2773 thioridazine 9.09 µM -1.09753224371631 0.165745417155861 no 2838 0.136204396813523 4195 5452 An antipsychotic. SGTC_142 0335-0849 62.6745 µM -1.09789637277488 0.165664380443358 no 2839 0.136124871015062 4201 3889043 YPR107C YTH1 SGTC_1155 4088-0394 48.2 µM -1.09881432057184 0.165460205412521 no 2840 0.135924532249148 4152 2326248 SGTC_510 ag-490 170 µM -1.10034983830539 0.165119031117321 no 2841 0.135589862573849 4315 5328779 SGTC_2131 toluylene red 5.2905 µM -1.10880074730067 0.163249493681583 no 2842 0.133758074018943 4166 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_1445 4239-0156 97.7 µM -1.11159898246752 0.1626335019512 no 2843 0.133155305119122 4279 4008346 SGTC_760 0568-0725 82.9 µM -1.1160355206423 0.161659964426084 no 2844 0.132203465179391 4240 3916171 SGTC_2848 9016370 25.97 µM -1.11856626184339 0.161106332876265 no 2845 0.131662611707184 4210 7894410 SGTC_1412 3909-8563 178 µM -1.12209269642522 0.160336946389054 no 2846 0.130911514459646 4286 23767530 SGTC_1954 st077032 68.9 µM -1.12393854652128 0.159935183541135 no 2847 0.130519548629552 4177 698907 SGTC_2216 7189485 200 µM -1.12531260642331 0.159636537164147 no 2848 0.130228294782763 4230 731273 SGTC_297 0986-0032 24 µM -1.12563314068126 0.159566922865598 no 2849 0.130160417186164 4163 2847425 SGTC_3221 9128209 49.47 µM -1.12629077468678 0.15942415875131 no 2850 0.130021230672237 4243 16460723 SGTC_2363 9053361 176 µM -1.12980421645809 0.158662851761548 no 2851 0.129279365566483 4294 6469797 YMR079W SEC14 SGTC_2082 5219693 150 µM -1.13314235831285 0.157941741380011 no 2852 0.128577237865913 4217 2834649 SGTC_826 1683-5028 118 µM -1.13497055703995 0.157547724592459 no 2853 0.128193827471651 4268 722377 SGTC_123 0083-0120 66.675 µM -1.13634816431402 0.157251247207663 no 2854 0.127905440332142 4212 16001701 SGTC_3035 9091303 49.47 µM -1.13662703532335 0.157191275540126 no 2855 0.127847116617592 4296 25237002 SGTC_1929 genistein trimethyl ether 50.5 µM -1.13802301197678 0.156891294576369 no 2856 0.127555436724269 4219 136420 SGTC_126 0417-1624 672.48 µM -1.13917205079875 0.156644660797939 no 2857 0.127315700230207 4280 41912 YDL195W SEC31 SGTC_686 1319-0111 510 µM -1.13952232033228 0.156569528484829 no 2858 0.127242682052663 4277 4562600 SGTC_890 0929-0006 47.2 µM -1.14284503994303 0.155857990058835 no 2859 0.126551467413647 4208 1378169 SGTC_2731 amoxapine 43.43 µM -1.14910440669213 0.154523387598079 no 2860 0.12525646576706 4378 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_3023 9089636 49.47 µM -1.15270864338539 0.153758340779859 no 2861 0.124514996273266 4310 17249241 SGTC_2031 5180455 200 µM -1.1579621638386 0.152647710078244 no 2862 0.123439738610903 4205 29949 SGTC_1053 3366-3204 134 µM -1.15889532976518 0.152450990331984 no 2863 0.123249426402533 4270 3632071 YPR165W RHO1 SGTC_3057 9095946 49.47 µM -1.15912208813677 0.15240321305375 no 2864 0.123203211797146 4289 24540043 SGTC_650 1328-0195 38 µM -1.15964791719036 0.152292460765162 no 2865 0.123096091674611 4242 2780821 SGTC_868 0527-0199 213 µM -1.16081599651812 0.15204662628476 no 2866 0.122858368118814 4210 2849450 SGTC_2969 9091408 28.7 µM -1.16161817606075 0.151877951966228 no 2867 0.1226952978236 4213 4286311 SGTC_536 3852-0578 10.6 µM -1.16393034238036 0.151392468501195 no 2868 0.12222612099952 4308 2869208 SGTC_1206 3978-0017 132 µM -1.16475062225962 0.151220483351362 no 2869 0.122059975701371 4330 3873677 SGTC_472 calcifediol 10 µM -1.1658027012976 0.151000088022009 no 2870 0.121847112405617 4309 5283731 A vitamin D metabolite. SGTC_2092 5303694 80.6725 µM -1.16965674869058 0.150194547545911 no 2871 0.121069565102291 4246 1963699 SGTC_2799 7812892 81.82 µM -1.17137716879834 0.149835886215086 no 2872 0.120723602623711 4287 20205235 SGTC_3172 9105863 49.47 µM -1.17162138679192 0.149785019670075 no 2873 0.120674548834672 4329 2348785 SGTC_2117 5521686 200 µM -1.17226451617121 0.149651121633915 no 2874 0.120545436575971 4222 803312 SGTC_1318 1280-3875 124 µM -1.17286570333091 0.149526028112831 no 2875 0.120424832473123 4265 373245 SGTC_390 dec-rvkr-cmk 16.7 µM -1.17407575609174 0.149274455005995 no 2876 0.120182341628706 4302 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_3184 9108758 49.47 µM -1.17696360784554 0.148675205805033 no 2877 0.119605015971205 4288 902885 SGTC_1579 chlormadinone acetate 49.4 µM -1.17716836531054 0.148632778352591 no 2878 0.119564156220825 4314 45114258 A steroidal progestin. SGTC_2387 9077560 195.08 µM -1.1791852979461 0.148215285681522 no 2879 0.11916219953008 4273 5303272 SGTC_3332 9141069 11.198 µM -1.18074180700619 0.147893634748035 no 2880 0.118852653958309 4221 17332883 SGTC_667 1498-1044 59 µM -1.18108799155178 0.147822159655066 no 2881 0.118783884930203 4272 6739982 SGTC_1076 itraconazole 331 nM -1.18301565470172 0.14742458712779 no 2882 0.118401471608689 4264 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_1817 st052116 64.4 µM -1.18802703780996 0.146394365392159 no 2883 0.11741137879954 4300 4361398 SGTC_1608 st001473 40.5 µM -1.18826069102669 0.146346450043528 no 2884 0.117365359697005 4220 7292267 SGTC_965 1291-5240 308 µM -1.18911557851158 0.146171227715065 no 2885 0.117197094447205 4294 2834598 SGTC_977 1348-1378 135 µM -1.19192658627195 0.145596062246861 no 2886 0.116645016242183 4269 X977 SGTC_121 0557-0495 61.343 µM -1.19259703000656 0.145459106586564 no 2887 0.116513614791163 4362 3104427 SGTC_1791 st048313 56.1 µM -1.19360508399744 0.145253348333008 no 2888 0.116316242168409 4279 1204976 SGTC_2359 9039622 200 µM -1.19610807294539 0.144743299595521 no 2889 0.115827193831644 4242 6463596 SGTC_3041 9091929 49.47 µM -1.19658086265576 0.144647092067828 no 2890 0.115734981660432 4291 25236887 SGTC_3349 9149703 23.001 µM -1.19684208983897 0.144593953676343 no 2891 0.115684054685029 4292 4910494 SGTC_476 mead acid 10 µM -1.19719945595474 0.14452128016982 no 2892 0.115614410939724 4337 5312531 An omega 9 fatty acid. SGTC_2203 7227154 166.4 µM -1.19756079912451 0.144447822921228 no 2893 0.115544022432526 4298 896304 SGTC_2649 anisomycin 9.56 µM -1.19788646326744 0.144381640401455 no 2894 0.115480610177845 4322 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_811 0416-0114 265 µM -1.2020428057373 0.143538769862179 no 2895 0.114673471922311 4328 6612453 SGTC_2197 6588183 93.1375 µM -1.20353987374738 0.143235992586834 no 2896 0.114383735442568 4252 884136 SGTC_6 0844-0013 19.835 µM -1.20478443853636 0.142984611881163 no 2897 0.114143264460063 4422 1584900 SGTC_2991 9074669 71.4286 µM -1.20722663445354 0.142492197160156 no 2898 0.11367243790293 4281 17333109 SGTC_919 tnp00227 403.569 nM -1.20731562497772 0.142474275876091 no 2899 0.113655307761461 4245 1269246 A methoxyflavone. YNL221C POP1 SGTC_152 4469-0003 551.229 µM -1.20794955075459 0.142346657362308 no 2900 0.113533334101772 4273 697280 SGTC_1789 tunicamycin 25 nM -1.21085787947747 0.141762159808098 no 2901 0.112974938971847 4191 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_186 3455-3465 67.277 µM -1.21328201693176 0.141276215724029 no 2902 0.112511007963097 4297 755278 SGTC_640 3381-0960 37.1 µM -1.21358622578341 0.141215313670788 no 2903 0.112452884770825 4352 1745025 SGTC_906 1165-0455 526 µM -1.21453141870418 0.141026201365076 no 2904 0.112272429826963 4288 3252859 SGTC_2780 5215298 71.43 µM -1.21483732067986 0.140965033917251 no 2905 0.112214071788077 4320 2834131 SGTC_2057 5236571 38.335 µM -1.21720813737854 0.140491581139271 no 2906 0.111762517450997 4269 54684039 YBR257W POP4 SGTC_2966 9084041 48.03 µM -1.21795734047103 0.140342189802717 no 2907 0.11162009214223 4215 17741380 SGTC_2232 chlorophetanol 41.5365 µM -1.21929091423956 0.140076541753418 no 2908 0.111366897942428 4362 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_1419 3993-2473 62.6 µM -1.22201139220578 0.139535682138543 no 2909 0.11085165946024 4375 704026 SGTC_36 0335-0881 14.2 µM -1.22257835714986 0.139423142631997 no 2910 0.110744495867833 4201 23828853 SGTC_1367 1812-0510 76.9 µM -1.22258666534887 0.139421493958117 no 2911 0.110742926064528 4348 1142582 YDR527W RBA50 SGTC_812 4251-0442 148 µM -1.22276899120464 0.139385316666834 no 2912 0.110708480286577 4329 5723007 SGTC_2225 6654152 15.4 µM -1.22577505615591 0.138789770625778 no 2913 0.110141668196543 4210 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_983 1491-0821 12.2 µM -1.22803784981375 0.138342622472998 no 2914 0.109716379887529 4297 46495113 SGTC_2240 6690706 185.951 µM -1.22854291818375 0.138242950669451 no 2915 0.109621614271369 4195 805876 SGTC_560 2332-1943 155 µM -1.23117619962774 0.137724083618548 no 2916 0.109128485473924 4285 21177716 SGTC_1335 1486-0900 202 µM -1.23201529660564 0.137559025836154 no 2917 0.108971685063432 4299 X1335 SGTC_3333 9141820 12.094 µM -1.23282791840891 0.137399304712575 no 2918 0.108819986443885 4294 1939433 SGTC_2332 7982454 138.89 µM -1.23340959896385 0.137285052972061 no 2919 0.10871149275981 4232 2981748 SGTC_92 0063-0024 660.874 µM -1.23997830599428 0.135999352838014 no 2920 0.107491709158982 4404 3594437 SGTC_1265 0819-1001 68.8 µM -1.24197965468255 0.135609270324881 no 2921 0.107122034352229 4262 3106768 SGTC_1382 3002-2117 298 µM -1.24576090922045 0.134874360581312 no 2922 0.106426092385642 4392 1497314 SGTC_1993 st073995 70.8 µM -1.24618852305177 0.134791423529804 no 2923 0.106347595770912 4313 3098394 SGTC_1296 1068-0102 11.9 µM -1.24664211417877 0.134703486352672 no 2924 0.106264376238133 4311 767053 SGTC_1472 k841-0093 193 µM -1.24668260911925 0.134695637560999 no 2925 0.106256948993217 4444 X1472 SGTC_3242 9133940 49.47 µM -1.24682525308559 0.134667992587814 no 2926 0.106230789410775 4329 17248444 SGTC_3030 9087619 49.47 µM -1.24986617645799 0.134079575661174 no 2927 0.105674218458832 4335 25236973 SGTC_1272 0839-0021 27 µM -1.25551350853838 0.132991511963024 no 2928 0.104646203685431 4341 5027250 SGTC_799 1310-0557 151 µM -1.25598451571467 0.132901039068873 no 2929 0.10456079207786 4372 5354492 SGTC_1663 st014140 55.4 µM -1.25605447310476 0.132887604996093 no 2930 0.104548110437261 4399 4207120 SGTC_619 1652-1634 108 µM -1.25663812754282 0.132775560981141 no 2931 0.104442350947259 4304 5400454 SGTC_1638 st008370 60.6 µM -1.25951891207078 0.132223490559029 no 2932 0.103921481812725 4271 24207134 SGTC_764 1951-2361 146 µM -1.25972757901207 0.132183563406025 no 2933 0.103883826445267 4343 5438930 SGTC_952 1185-0122 232 µM -1.26022561594884 0.132088300658321 no 2934 0.103793992294215 4297 678600 SGTC_2442 5158906 48.48 µM -1.26145283172501 0.131853765239881 no 2935 0.103572871968066 4343 1893835 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -1.2622625054491 0.131699184420599 no 2936 0.103427171860446 4291 6708514 SGTC_1204 4049-0315 18.3 µM -1.26303196131264 0.131552397824412 no 2937 0.103288846850901 4378 588402 SGTC_515 4092-1064 102 µM -1.27543476096586 0.129201928922689 no 2938 0.101077700823013 4340 717353 SGTC_1602 st001878 87.6 µM -1.27590898593496 0.129112639533253 no 2939 0.100993847096006 4327 595405 YLR310C CDC25 SGTC_728 3030-5151 22.5 µM -1.27621608742514 0.129054839795808 no 2940 0.100939571649071 4432 3125388 SGTC_1833 st055984 71 µM -1.27635556004776 0.129028595503503 no 2941 0.100914929039431 4352 676288 SGTC_1462 k081-0014 26.5 µM -1.27695471256625 0.128915896236711 no 2942 0.10080911814403 3809 3270634 SGTC_2849 9019321 12.99 µM -1.2810657771531 0.128144455420982 no 2943 0.100085281592849 4381 16489627 SGTC_2256 7954252 200 µM -1.28294382400259 0.127793109188076 no 2944 0.0997558788933352 4352 2972920 SGTC_689 0833-0039 98 µM -1.28301733811728 0.127779369749014 no 2945 0.0997430009078028 4301 5374726 SGTC_1486 3970-0793 4.53 µM -1.28332662260938 0.127721577191251 no 2946 0.099688834667405 4389 2844330 SGTC_1080 nisoldipine 24.4 µM -1.28399114622017 0.127597466506676 no 2947 0.0995725266700379 4358 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_1352 1496-0991 99 µM -1.28688770267986 0.127057466461123 no 2948 0.0990667160550167 4352 3000039 SGTC_276 colchicine 750 µM -1.29515809599472 0.125524392090512 no 2949 0.0976328485094443 4403 2833 A microtubule depolymerizer. SGTC_572 0960-0087 17.7 µM -1.29534297074179 0.125490270195081 no 2950 0.0976009709260273 4338 6796365 SGTC_1686 st019653 115.5 µM -1.29674265893084 0.12523214308187 no 2951 0.0973598730918568 4357 97252 SGTC_2677 mitomycin C 100 µM -1.29880204109445 0.12485303118156 no 2952 0.0970059370062517 4429 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1656 st012921 11 µM -1.301022143677 0.124445231256361 no 2953 0.0966254376191073 4264 6732821 SGTC_3122 9126309 49.47 µM -1.30309833544586 0.124064709202025 no 2954 0.0962705959199373 4458 17591206 SGTC_360 0957-0399 1.01 µM -1.30395222802295 0.123908445262835 no 2955 0.0961249355314456 4379 6752301 YPR165W RHO1 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -1.30410866895991 0.123879831216165 no 2956 0.0960982667858877 4404 5393153 SGTC_1099 5-nonyloxytryptamine 2.85 µM -1.30530603531399 0.123660978427885 no 2957 0.0958943298944411 4365 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_1502 4534-4282 27.7 µM -1.30745328516084 0.123269185773885 no 2958 0.0955294052584492 4337 3278949 SGTC_2314 7727897 200 µM -1.30745595112194 0.123268699877106 no 2959 0.0955289528150877 4350 900724 SGTC_346 4513-0042 7.16 µM -1.30936805098143 0.122920547096084 no 2960 0.0952048541753748 4328 2827372 SGTC_1509 1326-1131 80 µM -1.31048478562991 0.122717532637752 no 2961 0.0950159439117187 4352 768313 SGTC_508 roscovitine 141 µM -1.31217055358445 0.122411517614996 no 2962 0.0947312974509218 4445 160355 A CDKinase inhibitor. SGTC_1839 st053978 48 µM -1.31805086174814 0.121348267431976 no 2963 0.0937433111033116 4404 3788398 SGTC_2942 9052777 62.25 µM -1.32427786862867 0.120229426164665 no 2964 0.092705388921959 4424 6469503 SGTC_555 4296-0685 37 µM -1.32482171839607 0.120132055865374 no 2965 0.0926151448018283 4368 2908540 YHR072W ERG7 SGTC_1856 st057054 55.7 µM -1.32519344849142 0.120065533674282 no 2966 0.0925534988869756 4385 1266018 SGTC_1733 st037357 54.9 µM -1.32806983389946 0.119551673630314 no 2967 0.0920775189561149 4292 1272339 YGL099W LSG1 SGTC_16 erodoxin 22.806 µM -1.32849779381586 0.11947535229531 no 2968 0.0920068559584032 4403 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_614 0462-0418 107 µM -1.32874380470234 0.119431494872518 no 2969 0.091966253823724 4166 5188303 SGTC_3165 9101544 49.47 µM -1.33189406433343 0.118870888363964 no 2970 0.0914475009027542 4388 5002184 SGTC_670 4204-0025 119 µM -1.3352202164117 0.118281000648565 no 2971 0.0909021410347262 4407 719039 SGTC_3018 9082602 49.47 µM -1.33535794908807 0.118256618685152 no 2972 0.0908796103605171 4314 17332089 SGTC_2140 5586273 200 µM -1.33541681176744 0.118246199673228 no 2973 0.0908699827121079 4358 854421 SGTC_1432 4049-0298 68.4 µM -1.34238407876841 0.117017537899351 no 2974 0.0897357471529778 4411 741646 SGTC_2254 7938975 95.19 µM -1.34317370615629 0.116878861752726 no 2975 0.0896078668000644 4452 2969277 SGTC_407 eburnamonine 100 µM -1.34483457364731 0.116587556727115 no 2976 0.0893393312452787 4244 3195 SGTC_2656 pseudo-anisatin 100 µM -1.34623016593364 0.116343177588788 no 2977 0.0891141496795334 4451 6708809 A neurotoxin. SGTC_1238 0333-0287 48.8 µM -1.34633954735308 0.116324039415303 no 2978 0.0890965186384849 4383 7226 SGTC_2728 chlorpromazine 9.18 µM -1.34673921485913 0.116254129655698 no 2979 0.0890321188540156 4481 2726 A thorazine and dopamine antagonist. SGTC_1 0258-0098 57.368 µM -1.34692122332545 0.11622230265344 no 2980 0.089002802695399 4319 6790032 YDR047W HEM12 SGTC_694 1315-0438 43.2 µM -1.34883078675555 0.115888758584549 no 2981 0.0886956617791998 4408 6793154 SGTC_1362 1611-0397 101 µM -1.35132497168623 0.115454122945879 no 2982 0.088295678072195 4372 27816 SGTC_2777 climbazole 1.536 µM -1.35211373164013 0.115316915345624 no 2983 0.0881694676010841 4232 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_1605 st000082 49.1 µM -1.35244706097971 0.115258966373402 no 2984 0.0881161715977242 4364 1114022 SGTC_843 0310-0051 143 µM -1.35268678678596 0.11521730308086 no 2985 0.0880778567065834 4424 2065037 SGTC_2085 5307070 144.047 µM -1.35456144358779 0.114891865155122 no 2986 0.0877786623606365 4345 2840351 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -1.35675861718161 0.114511271656586 no 2987 0.0874289602569906 4450 6708784 An antioxidant flavonoid SGTC_918 glabranin 770.725 nM -1.35745234091735 0.114391291729718 no 2988 0.0873187634800436 4415 124049 Also referred to as licorice root. SGTC_2304 7443016 91.4 µM -1.35876230564653 0.114164976682848 no 2989 0.0871109607392934 4353 939854 SGTC_1650 st011916 45.8 µM -1.35932205983256 0.114068368494059 no 2990 0.0870222783449263 4350 242528 SGTC_3227 9130768 49.47 µM -1.36157418313525 0.113680262218399 no 2991 0.0866661536837972 4476 17720899 SGTC_3191 9110352 49.47 µM -1.36183963218625 0.113634579722395 no 2992 0.0866242505112124 4371 17122424 SGTC_1774 st048371 48.465 µM -1.36299831097509 0.113435329955135 no 2993 0.0864415214625127 4393 4242727 SGTC_1115 galangin 695.678 nM -1.36355076480058 0.113340416161444 no 2994 0.0863544984495035 4483 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_821 1114-0266 29.2 µM -1.37173468637918 0.11194101623622 no 2995 0.0850730231014857 4438 3123235 SGTC_3007 9078383 71.4286 µM -1.37261441250398 0.111791327166722 no 2996 0.0849361244837418 4420 6496995 SGTC_3308 9128332 17.569 µM -1.37556598250112 0.111290151329944 no 2997 0.0844780222559808 4395 17332805 YDL196W YDL196W SGTC_1573 oleylamine 1.06 µM -1.37583504897736 0.111244544035649 no 2998 0.0844363538168187 4414 5356789 An amine of the fatty acid oleic acid. SGTC_255 tunicamycin 200.472 nM -1.37789687752109 0.110895504150736 no 2999 0.0841175645765142 4339 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_1510 1123-0200 71.5 µM -1.3788183703062 0.110739761728261 no 3000 0.0839753806357984 4414 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_1157 4092-0394 27.6 µM -1.3822619412377 0.110159147697833 no 3001 0.0834456436516872 4479 3659885 SGTC_3334 9142812 21.919 µM -1.38226607123612 0.110158452660076 no 3002 0.0834450098304983 4428 45283678 SGTC_1617 st002906 78 µM -1.38235509154939 0.110143472189205 no 3003 0.0834313489709307 4405 5150859 SGTC_1159 4092-0538 61.2 µM -1.38609525000492 0.109515392721487 no 3004 0.082858910304774 4439 717301 SGTC_1539 benzyladenosine 56 µM -1.38771661188904 0.109243920387557 no 3005 0.0826116777819931 4435 92208 A nucleotide analog. SGTC_2998 9066762 71.4286 µM -1.39035300439108 0.108803529493802 no 3006 0.0822108548867461 4454 4945196 SGTC_1256 0570-0116 285 µM -1.39266845596615 0.108417803652765 no 3007 0.0818600358126434 4426 410638 SGTC_707 0865-0008 204 µM -1.39288633681438 0.108381558087619 no 3008 0.0818270823818631 4464 723043 SGTC_1731 st035964 63 µM -1.39512391618173 0.108009830097159 no 3009 0.0814892376427609 4347 6739575 SGTC_3310 9130229 44.1445 µM -1.3972814753285 0.107652266032673 no 3010 0.0811644721035412 4444 7761258 SGTC_1787 fluconazole 80 µM -1.40736400546271 0.105992630599344 no 3011 0.0796597394207195 4135 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_1377 2944-0135 198 µM -1.41372157758542 0.104955692204613 no 3012 0.0787218336448265 4450 1894137 SGTC_1764 st044502 93.5 µM -1.41416934890447 0.104882937212553 no 3013 0.078656092614415 4470 8407 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -1.41718913532752 0.104393228194988 no 3014 0.0782138187127926 4412 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_3152 9099253 49.47 µM -1.42336516814432 0.103396844796872 no 3015 0.0773151621906949 4319 25236131 SGTC_1242 0402-0103 60.1 µM -1.42367204344855 0.103347517054414 no 3016 0.0772707150625938 4366 432868 SGTC_526 4469-0568 170 µM -1.42566884676972 0.10302696414979 no 3017 0.0769819765318445 4402 2901964 SGTC_2830 7992007 71.43 µM -1.42751468092634 0.102731289708825 no 3018 0.0767157982930293 4344 1952075 SGTC_1927 st060202 13.8 µM -1.42845948358868 0.102580185581829 no 3019 0.0765798242462976 4378 688887 SGTC_1711 st032263 62.8 µM -1.43069823492001 0.102222782864471 no 3020 0.0762583596634507 4430 3958979 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -1.43072929940746 0.102217829991912 no 3021 0.0762539063170709 4511 279621 SGTC_1989 st071868 50.2 µM -1.43386299070378 0.101719095817005 no 3022 0.0758056825041742 4430 16414057 SGTC_738 1315-0003 72.4 µM -1.43493686051698 0.101548595205988 no 3023 0.0756525453434259 4473 6251474 SGTC_1154 4088-0362 150 µM -1.43756785595001 0.101131746245455 no 3024 0.075278353393714 4461 6618304 SGTC_1600 coumarin 106 71.1 µM -1.43871224053209 0.100950822240432 no 3025 0.0751160349002012 4519 100336 A hepatotoxic, DNA x-linker. SGTC_545 4218-0007 221 µM -1.43887605354915 0.100924943178321 no 3026 0.0750928216601747 4451 2840508 SGTC_814 3342-0569 96 µM -1.44201221999024 0.100430426202813 no 3027 0.0746494631565147 4489 4346283 SGTC_2546 rhodinyl acetate 100 µM -1.44518737506647 0.0999315649811184 no 3028 0.0742026307979652 4411 6708682 SGTC_3289 9119912 71.43 µM -1.44536264907273 0.0999040797873267 no 3029 0.0741780245095375 4458 17014829 SGTC_2793 7325131 81.82 µM -1.44623321497062 0.0997676457928249 no 3030 0.0740559002400528 4412 4176441 SGTC_2029 5175081 200 µM -1.44944980375088 0.0992647266070491 no 3031 0.073606004389278 4427 1380876 SGTC_3182 9108849 49.47 µM -1.45054892931611 0.0990933020684017 no 3032 0.0734527525398525 4486 17133045 SGTC_1002 4049-0206 172 µM -1.45179287196748 0.0988995525187647 no 3033 0.0732796032414778 4425 4662749 SGTC_1086 cerivastatin 2.18 µM -1.45684954612341 0.0981148064055424 no 3034 0.0725789578977249 4477 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_61 0978-8327 98.565 µM -1.4579970032066 0.097937369144113 no 3035 0.0724206845212647 4393 6150059 YHR072W ERG7 SGTC_162 k030-0015 37.8 µM -1.47037655223397 0.0960379910456995 no 3036 0.0707298991295199 4531 1809920 YMR134W ERG29 SGTC_1676 st018489 23.4 µM -1.47336528112823 0.0955835203458168 no 3037 0.070326283359846 4461 3696235 SGTC_116 0155-0182 31.788 µM -1.47881921071039 0.0947582700350025 no 3038 0.0695943200271897 4348 771486 SGTC_794 k038-0031 316 µM -1.47956030527957 0.0946465392685489 no 3039 0.0694953132242064 4466 6624242 SGTC_48 0382-0018 55 µM -1.47998768640884 0.0945821495215365 no 3040 0.0694382664160823 4505 762596 SGTC_1546 5-methoxyflavanone 78.7 µM -1.48426429320606 0.0939396083568407 no 3041 0.0688694095644244 4509 147795 SGTC_2043 5101342 149 µM -1.4871539384579 0.0935072793846009 no 3042 0.0684870791776086 4511 678451 SGTC_309 k408-0051 1.48 µM -1.48818178072513 0.0933538554918083 no 3043 0.0683514803556757 4415 3640463 SGTC_2498 4'-Methoxychalcone 54.63 µM -1.49024840047827 0.0930459384326483 no 3044 0.0680794671888753 4487 641818 YHR062C RPP1 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -1.49107380203708 0.0929231673213836 no 3045 0.0679710598001941 4470 688761 SGTC_2835 9006588 71.43 µM -1.49358757995786 0.0925500031215219 no 3046 0.0676417238376524 4462 2345538 SGTC_1336 1486-0901 104 µM -1.49393454767697 0.0924985838027132 no 3047 0.0675963637694867 4499 5006114 SGTC_2900 5328528 85.29 µM -1.49433446791736 0.0924393433422674 no 3048 0.0675441102294989 4493 795359 SGTC_3147 9097027 49.47 µM -1.49446963117645 0.0924193278643918 no 3049 0.0675264568701041 4501 25236841 SGTC_1980 st071811 45.7 µM -1.50200322723371 0.0913087894194928 no 3050 0.0665481376847181 4553 4974850 SGTC_3317 9138495 8.753 µM -1.50274837405333 0.0911994862213455 no 3051 0.0664519716481618 4411 17020139 SGTC_1437 4092-1038 11.6 µM -1.50483872905368 0.0908933766495722 no 3052 0.0661827719811638 4550 3977136 SGTC_2484 5809818 12.04 µM -1.5088346563087 0.0903103394199615 no 3053 0.0656705209305695 4476 2870548 SGTC_1104 tacrolimus 29.8 µM -1.51213683039603 0.0898306260121724 no 3054 0.065249528521204 4561 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_616 4092-0450 108 µM -1.51262300010519 0.089760159421788 no 3055 0.0651877242340053 4505 787165 SGTC_1273 0849-0096 14.1 µM -1.51668785619667 0.0891725969014074 no 3056 0.0646727558830713 4528 5286025 SGTC_317 4495-0002 170 µM -1.51681421003924 0.08915437881493 no 3057 0.0646567991501815 4511 15991618 SGTC_1172 0370-0043 85 µM -1.51779129451612 0.0890135932766177 no 3058 0.064533510197208 4521 376585 SGTC_3212 9128307 49.47 µM -1.5206787257308 0.0885985180248909 no 3059 0.064170239984127 4409 27243542 SGTC_24 0417-1663 219 µM -1.52302825050851 0.0882618333797134 no 3060 0.0638758188668137 4524 4329390 SGTC_1892 st058411 7.36 µM -1.52400313403257 0.0881224137719862 no 3061 0.0637539641501408 4510 3934738 SGTC_885 0865-0106 16.8 µM -1.52443325016187 0.0880609544195777 no 3062 0.0637002596838711 4472 2793380 SGTC_2979 9012552 45.46 µM -1.52495509570144 0.0879864307546708 no 3063 0.0636351491097946 4517 17100905 SGTC_1736 st036774 51 µM -1.5270333594985 0.0876901048247974 no 3064 0.0633763581513008 4543 1272247 SGTC_393 acivicin 6.25 µM -1.52714594933382 0.0876740726693107 no 3065 0.0633623615924873 4366 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_2152 5568786 200 µM -1.52769344912192 0.0875961429692925 no 3066 0.0632943336806396 4537 5399883 SGTC_509 pifithrin 175 µM -1.52868560926104 0.0874550531878037 no 3067 0.0631712007599594 4589 4817 A p53 inhibitor. SGTC_648 0375-0473 33.3 µM -1.53250573180854 0.086913397603037 no 3068 0.0626988421275507 4492 1713139 SGTC_216 k038-0035 28.382 µM -1.53286009821987 0.0868632792592774 no 3069 0.0626551645682543 4446 4444231 YPR107C YTH1 SGTC_2601 securinine 100 µM -1.53652365520265 0.0863464042087431 no 3070 0.0622050003461669 4472 442872 A GABA receptor antagonist. SGTC_1149 3909-7961 23.3 µM -1.53919400680841 0.0859711077580582 no 3071 0.0618784701559709 4562 735261 SGTC_3053 9095903 49.47 µM -1.54139048658704 0.0856633261856978 no 3072 0.0616108890026371 4622 17174018 SGTC_139 0099-0334 718.624 µM -1.54503713996982 0.0851541620408834 no 3073 0.0611686400609235 4526 97690 SGTC_2026 5148700 152 µM -1.54738047252605 0.0848281730862808 no 3074 0.0608857635873384 4504 79838 SGTC_236 1509-0011 5.31 µM -1.55163006920587 0.0842393857126582 no 3075 0.0603753820352785 4551 3107280 SGTC_2464 5717415 7.67 µM -1.56376975792931 0.0825743151814658 no 3076 0.0589358244124109 4495 5285744 SGTC_1628 st004252 77.7 µM -1.56583366088634 0.0822937128187994 no 3077 0.0586937818381034 4517 692968 SGTC_521 r062-0005 13.8 µM -1.57030936644238 0.0816876766342544 no 3078 0.0581715780904542 4464 2832033 SGTC_3158 9100007 49.47 µM -1.57908164059553 0.0805096294915766 no 3079 0.0571586661115431 4545 19297233 SGTC_2361 9034121 116 µM -1.58053713500856 0.0803154157152639 no 3080 0.0569919547950906 4553 6496917 SGTC_1316 1272-0050 65.9 µM -1.58555734851573 0.0796482600412473 no 3081 0.0564198789913869 4540 7340392 SGTC_1845 st056753 3.01 µM -1.59362887343337 0.0785844057031054 no 3082 0.0555095917615752 4503 5375839 SGTC_1820 st053765 18.6 µM -1.5949530848057 0.0784109034086481 no 3083 0.0553613636936815 4568 3690829 SGTC_98 0074-0023 107.663 µM -1.59498577534063 0.0784066238694754 no 3084 0.0553577083748916 4536 3563821 SGTC_3085 9117376 49.47 µM -1.60389118946033 0.0772473931153529 no 3085 0.0543690196102489 4605 16480349 SGTC_2776 terbinafine 19.92 µM -1.60574950935809 0.0770071433186586 no 3086 0.0541644791932123 4557 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2954 9074818 52.69 µM -1.60604822820448 0.0769685769890358 no 3087 0.0541316568754941 4546 16648742 SGTC_2726 cimetidine 79.27 µM -1.60632524450942 0.076932825704319 no 3088 0.0541012332359476 4550 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_160 3453-0671 289.699 µM -1.60783002589059 0.0767388414965563 no 3089 0.053936205219145 4534 5322268 SGTC_1616 st002734 56.1 µM -1.60881651672077 0.0766118730825964 no 3090 0.053828234109426 4528 4026101 SGTC_2222 6885208 172.143 µM -1.61792441695187 0.07544715829022 no 3091 0.0528394437382491 4574 609514 SGTC_63 0099-0242 26.702 µM -1.62491396558077 0.0745625267238161 no 3092 0.0520904460139897 4566 3898502 YLR359W ADE13 SGTC_2455 5377712 9.75 µM -1.6267796664426 0.074327738438147 no 3093 0.0518919508316936 4559 2243908 SGTC_589 1227-0070 34.1 µM -1.62724233248954 0.0742696018881181 no 3094 0.0518428201069201 4609 2841384 SGTC_876 0720-0963 56.8 µM -1.63155232602504 0.0737296947169053 no 3095 0.0513869141275639 4571 765861 SGTC_2682 pyrogallin 40.03 µM -1.63446627337403 0.0733663717341686 no 3096 0.0510804911925266 4566 822798 An ATP competetive kinase inhibitor. SGTC_1093 fluphenazine 7.97 µM -1.63733156950697 0.0730104516664994 no 3097 0.0507806039980047 4594 6602611 An atypical antipsychotic. SGTC_1047 2043-3044 82 µM -1.63741907705013 0.0729996025268638 no 3098 0.0507714674056354 4529 669592 SGTC_331 k048-0133 24.5 µM -1.63871267107254 0.0728393673184304 no 3099 0.0506365569363934 4563 6813582 SGTC_2822 7994718 71.43 µM -1.64134208676425 0.0725144963408308 no 3100 0.0503632121418978 4565 1018011 SGTC_215 1287-0124 461.5 µM -1.64422601399776 0.0721594573569952 no 3101 0.0500647626821637 4608 5560863 SGTC_1777 st045864 34.765 µM -1.65240806426392 0.071159420770778 no 3102 0.049225696347516 4585 4691462 SGTC_1221 2958-7315 257 µM -1.65955003219021 0.0702952351363967 no 3103 0.0485025038009355 4598 4562705 SGTC_339 3091-4833 71.4 µM -1.6596223984978 0.0702865202250704 no 3104 0.0484952197358997 4386 3240077 SGTC_2481 5478948 45.16 µM -1.66146864850023 0.0700644613896085 no 3105 0.048309680229153 4559 77792 SGTC_2301 7769476 200 µM -1.66272490630694 0.0699136730554468 no 3106 0.0481837571396188 4568 977820 SGTC_3319 9138450 16.7555 µM -1.66902722348138 0.0691609735459024 no 3107 0.0475559923716395 4516 2029690 SGTC_3088 9117578 49.47 µM -1.67140870882382 0.0688781786578939 no 3108 0.0473204884588967 4639 678341 SGTC_224 benfluorex 43.875 µM -1.67287753057021 0.0687042050500841 no 3109 0.047175703999848 4579 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_1050 3232-1156 69.3 µM -1.67344282483964 0.0686373395245827 no 3110 0.0471200766253573 4532 700529 SGTC_1118 chelidonine 707.474 nM -1.67421697974768 0.0685458504760042 no 3111 0.0470439818023286 4579 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_1476 4112-3294 3.34 µM -1.67720463061109 0.0681936539404583 no 3112 0.0467512369316645 4559 704369 SGTC_2624 nerol 100 µM -1.67762624778133 0.0681440646439367 no 3113 0.0467100427129034 4491 637566 A natural product oil. SGTC_3067 9117431 49.47 µM -1.68180016047608 0.067654642714185 no 3114 0.0463037988056998 4585 17150885 SGTC_128 0906-2981 13.371 µM -1.68201278770725 0.0676297834934513 no 3115 0.0462831801285961 4573 6740226 SGTC_837 0091-0265 12.5 µM -1.6823169703219 0.0675942323850694 no 3116 0.0462536960514194 4589 759367 SGTC_1426 4048-4480 71.7 µM -1.68469432352487 0.0673168782989202 no 3117 0.0460237811341995 4596 14224343 SGTC_734 2023-0417 80 µM -1.68588287254726 0.0671785464006982 no 3118 0.0459091807359957 4583 3935732 SGTC_1331 1472-0049 76.2 µM -1.68604698638927 0.0671594629318584 no 3119 0.0458933748414536 4563 24051409 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -1.68777578404158 0.0669586896359527 no 3120 0.0457271388967109 4650 688664 SGTC_1545 lovastatin 49.4 µM -1.69129257267599 0.066551701819701 no 3121 0.0453904689428847 4618 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_2081 5214970 32.255 µM -1.69354411972297 0.0662921438845227 no 3122 0.0451759721542902 4529 2063512 SGTC_2191 5911152 200 µM -1.69688459319265 0.0659084999419837 no 3123 0.0448592406852277 4610 2875902 SGTC_2759 disulfiram 3.38 µM -1.7041577917251 0.0650791468169245 no 3124 0.0441758061242677 4497 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_2101 5377231 179.231 µM -1.7051546075306 0.0649661151187067 no 3125 0.0440827966678048 4608 2844213 SGTC_2286 7945697 125 µM -1.70708114432421 0.0647480917243598 no 3126 0.0439034856331679 4555 1245733 SGTC_1049 3226-0134 66 µM -1.70726878134212 0.0647268875133891 no 3127 0.0438860529352496 4608 5702385 SGTC_1522 st012842 45.6 µM -1.70760595992873 0.0646887976787532 no 3128 0.0438547408851976 4438 3491067 YOR116C RPO31 SGTC_1675 st018485 24.5 µM -1.70901098310401 0.0645302647124869 no 3129 0.0437244575234427 4580 3323024 SGTC_2655 perillic acid 100 µM -1.71120768144329 0.064283009694756 no 3130 0.0435213905898594 4639 5702197 An apoptosis inducer. SGTC_2706 st078239 82.5 µM -1.71273880829828 0.0641111056838488 no 3131 0.0433803010519243 4571 15434492 SGTC_2334 9017922 200 µM -1.71421953206152 0.0639452007043604 no 3132 0.0432442075060252 4596 3163164 SGTC_3070 9117005 49.47 µM -1.71466428294099 0.0638954346614379 no 3133 0.0432033977871944 4679 8779016 SGTC_137 0438-0332 85.389 µM -1.7155149645781 0.0638003303211483 no 3134 0.0431254270750619 4544 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_1477 0139-0234 16 µM -1.71633720760457 0.063708510039182 no 3135 0.0430501710205435 4613 620880 SGTC_3066 9117245 49.47 µM -1.7213530934203 0.0631506083186324 no 3136 0.0425933852498278 4630 17176980 SGTC_44 0929-0055 61.211 µM -1.72676859131552 0.0625525381446425 no 3137 0.0421046157120281 4452 1379590 SGTC_3036 9090181 49.47 µM -1.72751285672133 0.0624706901274857 no 3138 0.0420377991040716 4654 25236586 SGTC_279 1273-0055 2.93 µM -1.72805118729817 0.062411541139756 no 3139 0.0419895238563618 4639 2847562 SGTC_2319 6033012 152.6 µM -1.72997396070479 0.062200633196949 no 3140 0.0418174638245445 4550 847246 SGTC_3324 9138759 60.749 µM -1.73077933672034 0.0621124573276888 no 3141 0.0417455643385432 4603 45595710 SGTC_879 0831-1030 162 µM -1.7374237123258 0.0613887202757083 no 3142 0.0411562043916148 4607 1549252 SGTC_2552 juarezic acid 87.02 µM -1.73742496409823 0.0613885845500427 no 3143 0.0411560939976385 4566 1549512 SGTC_2058 5236698 133 µM -1.73857766119918 0.0612637007694507 no 3144 0.041054539347572 4578 766665 SGTC_2424 5537928 59.2 µM -1.7470209900148 0.060354989396505 no 3145 0.0403168486017935 4607 5382802 SGTC_2508 celastrol 40.54 µM -1.7500739863349 0.0600290202790316 no 3146 0.0400527739344451 4557 122724 Celastrol is a natural product and antioxidant. SGTC_1500 4488-1866 171 µM -1.75580537003422 0.0594208040841545 no 3147 0.0395608235779328 4647 2900003 SGTC_2896 9052656 71.43 µM -1.75624529482533 0.0593743194922962 no 3148 0.0395232668406964 4283 6469436 SGTC_1339 1486-1321 22.7 µM -1.76715089504435 0.0582310694222848 no 3149 0.0386014804466389 4668 3469382 SGTC_792 4534-1957 155 µM -1.76742991447281 0.0582020479073877 no 3150 0.0385781283866656 4587 1717904 SGTC_3339 9145883 14.936 µM -1.76860768104535 0.05807967063233 no 3151 0.0384796840238686 4544 2030670 SGTC_2803 7707263 71.43 µM -1.77260121896193 0.0576662218682383 no 3152 0.0381474048039659 4574 2199229 SGTC_158 k038-0087 26.446 µM -1.77893077469394 0.0570156718523332 no 3153 0.0376255559721171 4526 X158 SGTC_1635 st007035 42.4 µM -1.78070890943811 0.0568339590988338 no 3154 0.0374800084545383 4579 3716403 SGTC_244 nsc-207895 1.295 µM -1.78135841387826 0.0567676981959852 no 3155 0.0374269586741496 4443 42640 SGTC_1838 st055369 84.5 µM -1.78222439189956 0.0566794478367542 no 3156 0.0373563233217258 4592 676036 SGTC_2260 7964312 200 µM -1.78389566011731 0.0565094373085607 no 3157 0.0372203106274995 4634 231951 SGTC_2016 5121758 140 µM -1.7871029971398 0.0561842952998894 no 3158 0.0369604215897117 4540 2795203 SGTC_2838 9002687 71.43 µM -1.78875909041675 0.0560169881927549 no 3159 0.0368268109803694 4608 6457060 SGTC_3241 9133421 49.47 µM -1.78982912771923 0.0559090966284197 no 3160 0.0367406925318988 4699 17018221 SGTC_93 0109-0045 59.227 µM -1.79005877505631 0.0558859627316667 no 3161 0.036722231601802 4702 88733 SGTC_1900 st060200 72.8 µM -1.79174523316204 0.0557163059230176 no 3162 0.0365868926281293 4622 688945 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -1.79686514750272 0.0552037343362826 no 3163 0.0361785154022183 4621 6708561 SGTC_1908 st060353 56.5 µM -1.79991158184442 0.0549005176716461 no 3164 0.0359373002958184 4616 4227716 SGTC_1114 scopoletin 1.73284 µM -1.80079865963749 0.0548124732269406 no 3165 0.0358673101161377 4656 5280460 A coumarin with genotoxic properties. SGTC_1958 st076513 41.9 µM -1.80259089625689 0.0546349303168246 no 3166 0.0357262439056823 4561 732122 YGL099W LSG1 SGTC_2724 maprotiline 69.64 µM -1.81134824630634 0.053773938290298 no 3167 0.0350434808915252 4558 4011 A tricyclic antidepressant. SGTC_849 0386-0493 241 µM -1.81141763490069 0.053767159405105 no 3168 0.035038114101892 4647 726119 SGTC_474 dl-dihydrosphingosine 5 µM -1.81287350052398 0.0536250853189134 no 3169 0.0349256671218537 4603 3058739 A sphingolipid protein kinase C inhibitor. SGTC_1959 st077091 55.8 µM -1.81745587945225 0.0531798434249825 no 3170 0.0345736690817798 4616 821356 YKL052C ASK1 SGTC_2144 5628481 200 µM -1.81909460473251 0.0530213317548997 no 3171 0.034448499027463 4628 2818399 SGTC_1886 st057356 49.9 µM -1.81932473911557 0.0529991012035294 no 3172 0.0344309506241031 4622 24207747 SGTC_2120 5538279 151.968 µM -1.82107468076202 0.0528303018264966 no 3173 0.0342977527242135 4639 2058197 SGTC_1303 1160-0052 261 µM -1.82191158936729 0.0527497245182221 no 3174 0.0342342007676342 4596 3562476 SGTC_2673 kobusone 100 µM -1.82258337068462 0.0526851161889937 no 3175 0.0341832580693435 4732 6710676 An epoxy ketone and protein crosslinker. SGTC_2734 clemastine 41.6 µM -1.82677641356483 0.0522832697638297 no 3176 0.0338666968045022 4702 26987 Clemastine is a selective histamine H1 antagonist. SGTC_222 nsc-310342 10.666 µM -1.82963946584726 0.0520102860216836 no 3177 0.0336519341044798 4654 432556 SGTC_999 SEC7.066 22.7 µM -1.83190775180181 0.0517948164981205 no 3178 0.0334825827280877 4614 740511 YDR170C SEC7 SGTC_878 0828-0289 13.7 µM -1.83385078906764 0.0516108077805382 no 3179 0.0333380730825161 4613 745350 YLR208W SEC13 SGTC_1241 0364-0022 50.8 µM -1.84695183926104 0.0503836481657027 no 3180 0.0323770602975335 4645 4563895 SGTC_2422 chlorphenesin carbamate 384.24 µM -1.84769633362187 0.0503146165246739 no 3181 0.0323231423360271 4589 2724 A muscle relaxant with antifungal properties. SGTC_2418 pentamidine 31.67 µM -1.84984838358043 0.0501154961082607 no 3182 0.0321677025462884 4586 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_3316 9136639 10.545 µM -1.85147073024249 0.0499658027085649 no 3183 0.0320509309017163 4646 4903665 SGTC_1594 piperine 70.1 µM -1.85380999370541 0.0497505876134839 no 3184 0.0318831741094689 4626 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1775 st081588 35.1725 µM -1.86047022729175 0.0491418863259304 no 3185 0.0314095134608584 4614 1426443 YGL099W LSG1 SGTC_1749 st037932 54.2 µM -1.87123635643747 0.0481705272048493 no 3186 0.0306561637886213 4613 594497 SGTC_1572 epiandrosterone 68.9 µM -1.87636286308401 0.0477134256258331 no 3187 0.0303027351943853 4613 441302 A steroid. SGTC_420 mitomycin C 81.9 mM -1.87825060109158 0.0475459843025777 no 3188 0.0301734454290381 4635 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2 0422-0095 29 µM -1.89179708337258 0.0463581854982471 no 3189 0.0292590110318984 4593 6790840 SGTC_2871 9038510 12.99 µM -1.89461708466358 0.0461139399612394 no 3190 0.0290715748520501 4612 4945164 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -1.89496122526593 0.0460842042010807 no 3191 0.0290487694187478 4649 688667 SGTC_1085 doxorubicin 7.67 µM -1.90375966547029 0.045329184381999 no 3192 0.0284707458974928 4667 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_363 0455-0021 3.06 µM -1.90586863585902 0.0451496938635415 no 3193 0.0283336256006696 4597 4597466 SGTC_1707 st032323 6.317 µM -1.90934086157915 0.0448554255434077 no 3194 0.0281090671710183 4476 3132057 YMR211W DML1 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -1.90971269891993 0.0448240043744106 no 3195 0.0280851075076728 4625 279621 SGTC_2984 9022109 38.96 µM -1.91838665820755 0.0440960488964423 no 3196 0.0275310007555282 4657 6459207 SGTC_1905 st060207 84.5 µM -1.92210138119268 0.0437872228023758 no 3197 0.0272965011625685 4660 1948547 SGTC_3296 9122258 64.045 µM -1.92435505011895 0.0436007144353134 no 3198 0.0271550473212302 4638 4730474 SGTC_1655 st012546 55.1 µM -1.92989927716628 0.0431446150392568 no 3199 0.0268096595073627 4662 720985 YLR208W SEC13 SGTC_1766 st045414 44.774 µM -1.93131628834633 0.0430286641702488 no 3200 0.0267219751411456 4666 253960 SGTC_3268 9137683 49.47 µM -1.9397813245323 0.0423412235449298 no 3201 0.026203135611042 4711 1953228 SGTC_723 4182-0001 115 µM -1.94205823805047 0.0421578408936111 no 3202 0.0260650252130787 4663 744821 YLR208W SEC13 SGTC_1042 0350-0096 82 µM -1.94733723516478 0.0417351424772519 no 3203 0.0257471587167511 4656 3122515 SGTC_3206 9114350 49.47 µM -1.9613691040291 0.0406282560814284 no 3204 0.0249179906983512 4558 17087243 SGTC_2681 menadione 3.18 µM -1.96502238871839 0.0403440144921166 no 3205 0.0247058231592236 4699 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_1906 st060206 94.7 µM -1.97115886487744 0.0398702058247869 no 3206 0.0243528536918728 4684 5133468 SGTC_1449 4112-4002 201 µM -1.97365440210059 0.0396788190106112 no 3207 0.0242105266448015 4695 2059539 SGTC_223 busulfan 5 mM -1.97390058665139 0.0396599792673802 no 3208 0.0241965240292593 4681 2478 A DNA alkylator. SGTC_2779 methotrexate 400 µM -1.98512811715239 0.0388084722714269 no 3209 0.0235651096291342 4659 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_2671 danthron 100 µM -1.98625271003316 0.0387240087716059 no 3210 0.0235026353600113 4670 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_1310 1188-0297 994 nM -1.98784914390233 0.0386043645031488 no 3211 0.0234141883447045 4589 1588352 SGTC_1422 4031-0024 15.5 µM -2.00226744491638 0.0375373796151615 no 3212 0.0226279876751484 4650 782427 SGTC_380 3970-0968 6 µM -2.0065168205553 0.0372275517077679 no 3213 0.0224005679842738 4629 2891601 SGTC_829 1635-0120 117 µM -2.01563331534808 0.0365699033373835 no 3214 0.0219191666913084 4674 285054 SGTC_972 1319-0219 195 µM -2.01980062981242 0.036272461878853 no 3215 0.0217020359009827 4674 23903702 SGTC_68 0986-0284 82.829 µM -2.02218770956462 0.0361029784297658 no 3216 0.021578481751294 4626 423278 YIL048W NEO1 SGTC_2367 9070478 135.38 µM -2.0244294497941 0.0359444051392528 no 3217 0.0214629920867265 4639 572802 SGTC_2790 5423970 71.43 µM -2.0255518874224 0.0358652222239861 no 3218 0.0214053630771925 4662 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_1407 3909-7909 12.3 µM -2.03357092557946 0.0353036639395381 no 3219 0.0209974378724918 4706 4411780 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -2.03394887384174 0.0352773759018308 no 3220 0.0209783752565871 4704 4174840 SGTC_74 000s-0487 160.283 µM -2.0341770866559 0.0352615104284529 no 3221 0.0209668719564937 4600 677548 SGTC_629 3448-6466 76.7 µM -2.03479810998479 0.0352183661967968 no 3222 0.020935595667471 4715 573744 SGTC_3113 9123498 49.47 µM -2.0435186227926 0.0346170884954691 no 3223 0.0205005628913631 4745 8897275 SGTC_1473 k844-0725 134 µM -2.04840417801581 0.0342839320838543 no 3224 0.0202602062499652 4717 54682906 SGTC_479 n-linoleoylglycine 10 µM -2.05804367380931 0.0336343230423665 no 3225 0.0197929705904595 4715 6433346 An anti-infammatory. SGTC_706 4262-0057 46.9 µM -2.06451411677267 0.0332039856653416 no 3226 0.0194844984164715 4699 883298 SGTC_73 0327-0325 16.231 µM -2.06660760337793 0.0330657266177079 no 3227 0.0193855718900584 4535 53298 SGTC_338 4055-0136 114 µM -2.08247006170572 0.032033473896592 no 3228 0.0186497773638175 4686 2900563 SGTC_1550 gossypolone 36.6 µM -2.08504651474335 0.0318683495431166 no 3229 0.0185325392497416 4721 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1184 1269-1718 139 µM -2.08936869054812 0.0315929215363875 no 3230 0.0183372736846989 4726 5403821 SGTC_1834 st055981 52.8 µM -2.091182628767 0.0314779169885743 no 3231 0.0182558479532532 4677 471719 YDL150W RPC53 SGTC_963 1269-2853 151 µM -2.1013536797379 0.0308394611213705 no 3232 0.0178049654257227 4695 3668223 SGTC_2437 5741531 144.16 µM -2.10158815107751 0.0308248702669418 no 3233 0.0177946843506693 4706 2262990 SGTC_663 1486-0733 13.9 µM -2.10453066248605 0.0306422468816076 no 3234 0.0176660914013693 4717 722445 YPR165W RHO1 SGTC_2725 haloperidol 53.21 µM -2.10484983974146 0.0306224915115291 no 3235 0.0176521905851 4688 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2603 homopterocarpin 100 µM -2.10625014229876 0.0305359448594782 no 3236 0.0175913148309655 4679 101795 A weak amylase inhibitor. SGTC_2261 9010538 184.68 µM -2.11048464433058 0.0302754604941839 no 3237 0.0174083162269671 4679 6457250 SGTC_2621 lithochol-11-enic acid 100 µM -2.1174600721254 0.0298503855596159 no 3238 0.0171104102655024 4655 6708711 SGTC_1952 st077036 64.1 µM -2.12747579419887 0.0292487061942749 no 3239 0.0166902852187621 4715 2937007 SGTC_1381 2324-0066 62.1 µM -2.12782869851747 0.0292276910704221 no 3240 0.0166756445027913 4711 10885928 SGTC_539 4859-0462 2.54 µM -2.13242911338024 0.0289548861848533 no 3241 0.0164857930812814 4695 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_1715 st032160 10.2275 µM -2.15495824715265 0.0276492902570136 no 3242 0.0155825508325526 4644 5289825 SGTC_308 4092-1169 104 µM -2.16668969374251 0.0269890983035844 no 3243 0.0151292614887966 4684 2268590 YDL196W YDL196W SGTC_2265 7929201 200 µM -2.18415243630204 0.0260307827389803 no 3244 0.0144755243257219 4701 1265108 SGTC_2507 purpurin 79.67 µM -2.18701871307013 0.0258762401214708 no 3245 0.014370578971291 4701 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_1956 st077085 54 µM -2.18736465648578 0.0258576397270526 no 3246 0.0143579570766511 4714 24208685 SGTC_3247 9135149 49.47 µM -2.19580271852533 0.02540740206361 no 3247 0.0140530335037356 4732 8934436 YOR116C RPO31 SGTC_200 k038-0079 37.545 µM -2.19677891807506 0.0253557404099063 no 3248 0.0140181197108918 4738 3436683 SGTC_1864 st057645 30.4 µM -2.1972599875585 0.0253303140195117 no 3249 0.0140009417712516 4750 688666 SGTC_1044 1222-0021 1.78 µM -2.21041578717615 0.0246432145550536 no 3250 0.0135381595683525 4668 4306703 SGTC_2042 p-Dimethylaminoacetophenone 200 µM -2.21084884827034 0.0246208652018367 no 3251 0.0135231529295762 4735 75037 A free radical scavenger. SGTC_191 3914-0123 66.505 µM -2.21213782992204 0.0245544442526299 no 3252 0.0134785714681279 4758 3144412 SGTC_2816 7982706 58.44 µM -2.22273417946875 0.0240140954713736 no 3253 0.0131168648583039 4692 2981853 SGTC_2939 9044578 71.43 µM -2.22345493631599 0.0239777070816592 no 3254 0.0130925694182146 4680 2653634 SGTC_1168 k815-0004 80.5 µM -2.22500521956909 0.0238995959190949 no 3255 0.0130404438761485 4718 642433 SGTC_294 k038-0071 157 µM -2.22707825379294 0.0237954802020112 no 3256 0.0129710221489916 4752 24152826 SGTC_2114 5491910 81.25 µM -2.25393702334259 0.0224806535540246 no 3257 0.0121000650605524 4735 2849228 SGTC_1392 3455-1037 33.9 µM -2.26622499360633 0.0218998562268082 no 3258 0.0117188055533962 4740 981132 SGTC_2516 gossypol 71.55 µM -2.26807019972965 0.0218137454291697 no 3259 0.0116624641759046 4740 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2062 5245942 200 µM -2.26945613495706 0.021749255786231 no 3260 0.0116203009216626 4744 1376160 SGTC_1036 k216-0215 33.5 µM -2.29006409586466 0.0208091815861586 no 3261 0.0110088006638653 4698 622330 SGTC_245 methotrexate 289.6 µM -2.29123417249976 0.0207568544685035 no 3262 0.0109749367653344 4704 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_2089 5281248 129.67 µM -2.29669089382872 0.0205142929562716 no 3263 0.0108182046459355 4735 2737878 SGTC_1653 st012112 65 µM -2.29949837339863 0.0203904337173156 no 3264 0.0107383278169999 4738 720429 SGTC_932 2857-0803 154 µM -2.30009949527266 0.0203639962089948 no 3265 0.010721291937793 4710 674898 SGTC_340 k038-0059 454 µM -2.30830911553608 0.0200058329972355 no 3266 0.0104909749019766 4746 23733424 SGTC_381 3461-2219 42.7 µM -2.31842855938721 0.0195717158674579 no 3267 0.010213020707741 4733 2883159 SGTC_1829 berberine 14.4 µM -2.32605969896998 0.0192496599880568 no 3268 0.0100076830579176 4686 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1046 2001-0062 216 µM -2.32772948423546 0.01917979407855 no 3269 0.00996323625326611 4727 739778 SGTC_2622 2-methoxyxanthone 59.94 µM -2.34923925480272 0.018298901693877 no 3270 0.00940590733157515 4731 71034 A hepatoprotective. SGTC_403 arphamenine a 50 µM -2.36549914969658 0.0176560999125089 no 3271 0.0090028923208459 4753 5487158 An arginine aminopeptidase inhibitor. SGTC_1937 st074714 47.2 µM -2.4021572312819 0.0162772608343553 no 3272 0.00814935062455975 4718 17250970 SGTC_2584 androsterone 48.74 µM -2.42097128631923 0.0156061421421658 no 3273 0.00773954995095703 4678 2754130 A steroid. SGTC_2124 5246320 200 µM -2.42140489429655 0.0155909590346248 no 3274 0.00773032302016103 4749 579342 SGTC_1298 1079-1278 263 µM -2.42940542105379 0.015313080920031 no 3275 0.00756180510553759 4739 2840950 SGTC_2428 5615643 7.78 µM -2.4330754770924 0.0151870405645634 no 3276 0.00748558987087891 4741 2253075 SGTC_752 1896-0090 130 µM -2.45268133272185 0.0145287123530329 no 3277 0.00708979458070612 4772 772567 SGTC_2451 5856223 45.7 µM -2.46813648478068 0.0140272119957652 no 3278 0.0067909261467726 4740 2179896 SGTC_2956 9076196 2.52 µM -2.47876339998396 0.0136911020669661 no 3279 0.00659193636567031 4746 16423868 SGTC_2553 4-methylesculetin 85.09 µM -2.47884747476247 0.0136884708836304 no 3280 0.00659038283546462 4753 5319502 SGTC_2293 7624732 200 µM -2.48509106898539 0.0134942882445176 no 3281 0.00647591482403357 4692 894453 SGTC_1747 st037496 66.6 µM -2.49088023897857 0.0133163680303834 no 3282 0.00637135319849305 4725 723305 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -2.49340855454363 0.0132393025021579 no 3283 0.00632615850935656 4794 4620898 SGTC_917 harmaline 728.087 nM -2.49791418240358 0.0131029214714442 no 3284 0.00624632162672125 4704 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_3079 9117512 49.47 µM -2.50205918878573 0.0129785301407387 no 3285 0.00617366401781182 4790 7185044 SGTC_514 4466-0038 2.65 nM -2.51719305524571 0.012532993917001 no 3286 0.00591469958836105 4631 5722064 SGTC_1376 2910-0861 41.3 µM -2.52173075999703 0.012402012372211 no 3287 0.00583895261373507 4734 1112859 SGTC_975 1335-0046 28.5 µM -2.53178488329778 0.0121160156759389 no 3288 0.00567417945887864 4763 16486740 SGTC_1239 0337-0584 35.4 µM -2.54526492369739 0.0117415487932989 no 3289 0.00545974294462397 4759 914301 YML130C ERO1 SGTC_2105 5350118 200 µM -2.55748603518772 0.0114107770467555 no 3290 0.0052715895574273 4766 2133313 SGTC_1063 disulfiram 1.84 µM -2.56319776354792 0.0112589819016953 no 3291 0.00518564772980504 4763 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_2733 amorolfine 100 µM -2.57332071269889 0.010994263090662 no 3292 0.00503639098818045 4806 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_941 3237-0776 460 µM -2.58037997128618 0.010812880742472 no 3293 0.00493458289066323 4757 760008 SGTC_1393 3470-5649 58.2 µM -2.60219136169062 0.0102688125555041 no 3294 0.00463150748241582 4763 4108395 SGTC_2091 4-phenylthiadiazole 200 µM -2.60789378615647 0.010130568063104 no 3295 0.00455506087087313 4775 270010 SGTC_298 1391-0729 10 µM -2.6184456301754 0.00987903650342222 no 3296 0.00441656833144227 4755 3237558 SGTC_1962 st076595 64.5 µM -2.64584015234208 0.00925131093116178 no 3297 0.00407441565050242 4753 279619 SGTC_2727 riluzole 51.77 µM -2.68001859302573 0.00851728224760196 no 3298 0.00368090354794339 4788 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_2789 5281112 71.43 µM -2.69520767247846 0.00820782358894041 no 3299 0.00351723863817367 4760 765948 SGTC_2168 5727979 200 µM -2.70086658370425 0.0080950812679643 no 3300 0.00345795374844571 4763 695210 SGTC_1677 st019204 53.9 µM -2.71507810850368 0.00781792610880659 no 3301 0.00331300703706667 4772 3945625 SGTC_1547 harmine 94.2 µM -2.71801089688847 0.00776178098511468 no 3302 0.00328378375705761 4724 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_3091 9116372 49.47 µM -2.7219502908711 0.00768692400995723 no 3303 0.00324489517965588 4784 17169793 SGTC_147 4466-0538 29.23 µM -2.72929079608735 0.00754913242505379 no 3304 0.00317353534459415 4758 6742687 YHR072W ERG7 SGTC_2501 sodium tetradecyl sulfate 13.37 µM -2.74204394414309 0.00731490507775502 no 3305 0.00305290862052845 4775 23665772 A membrane-active detergent. SGTC_2399 5884133 200 µM -2.74707900549127 0.0072242087323455 no 3306 0.00300643241315516 4731 722445 SGTC_2566 crystal violet carbinol 226 nM -2.75907366428936 0.00701213364577383 no 3307 0.00289827334635745 4713 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -2.7591976085583 0.00700997120530424 no 3308 0.00289717426053748 4781 688664 SGTC_1370 2001-0092 44.6 µM -2.76478359978572 0.00691312213512266 no 3309 0.00284802846929137 4736 790957 SGTC_1121 fusaric acid 630.51 nM -2.76723410926887 0.00687100973991817 no 3310 0.00282670705627979 4764 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_1912 st060209 90.8 µM -2.7702200263768 0.00682000261630595 no 3311 0.00280092183852453 4761 688787 SGTC_1337 1486-1011 40.3 µM -2.80081171439143 0.00631637925567881 no 3312 0.00254871254110791 4786 X1337 SGTC_2575 plumbagin 510 nM -2.8149767188312 0.00609454634581213 no 3313 0.00243903838199126 4732 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2366 9070441 60.58 µM -2.81612966197883 0.00607679806623389 no 3314 0.00243030227053393 4767 6837235 SGTC_1879 gemcitabine 100 µM -2.83557024740947 0.00578435282874371 no 3315 0.00228719769317293 4776 60750 A nucleoside analog which inhibits DNA replication. SGTC_1109 tnp00067 928.257 nM -2.86889542711035 0.0053119989047992 no 3316 0.00205953979465745 4787 676295 SGTC_1373 2887-0003 58.5 µM -2.88547757814812 0.00508999915243221 no 3317 0.00195410149734965 4776 776948 SGTC_193 1273-0060 1.558 µM -2.90863064585606 0.00479385213545977 no 3318 0.00181507731575796 4754 2847393 YHR072W ERG7 SGTC_314 1671-0008 2.74 µM -2.9192378294918 0.00466338392860616 no 3319 0.00175444203189394 4718 3913060 SGTC_1978 st071761 42 µM -2.93352252947512 0.00449269099825264 no 3320 0.00167569665198903 4785 5147680 SGTC_929 2805-0021 398 µM -2.94514165187727 0.00435798836569736 no 3321 0.00161403418854651 4786 3098024 SGTC_1986 st071812 45 µM -2.94757443828223 0.00433024586291401 no 3322 0.00160138816218551 4774 11838594 SGTC_67 0335-0847 266 µM -2.95695288934725 0.00422476916900997 no 3323 0.00155347792171962 4760 4552207 YOR254C SEC63 SGTC_2138 5575593 77.673 µM -2.99295228116909 0.00384090968126386 no 3324 0.0013814647270552 4796 762213 SGTC_1678 st019265 80.2 µM -2.99370133186213 0.00383326581563433 no 3325 0.0013780779944282 4775 5367020 SGTC_1904 st060225 78 µM -3.00156251176383 0.00375386314603162 no 3326 0.00134298942398666 4785 66595 SGTC_1371 2421-0008 32.7 µM -3.04694125987498 0.00332367264725703 no 3327 0.00115591441102211 4785 2827552 SGTC_217 ketoconazole 989 nM -3.0527243546322 0.00327215978628829 no 3328 0.00113387070318463 4710 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_574 1315-0397 40 µM -3.0557054307502 0.00324588733989871 no 3329 0.0011226586444373 4788 6794277 SGTC_1186 1319-0216 26 µM -3.08647799842714 0.00298557064639254 no 3330 0.00101271467576241 4801 4565136 SGTC_3037 9091026 49.47 µM -3.11127879862004 0.00278962979027173 no 3331 0.000931394881025949 4740 25236398 YIL048W NEO1 SGTC_1455 4262-0120 131 µM -3.13817316256685 0.00259032779184822 no 3332 0.000850022056545012 4788 1529587 SGTC_1786 berberine 21.6 µM -3.15031079893068 0.00250466956503841 no 3333 0.000815484285291177 4754 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2929 9013348 24.6 µM -3.15378497790391 0.00248062740347995 no 3334 0.000805838930038884 4784 2995952 SGTC_1827 berberine 7.24 µM -3.18604185606578 0.00226716906097047 no 3335 0.000721168642742831 4770 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2571 chrysanthemic acid 100 µM -3.20866820533735 0.00212752182381919 no 3336 0.0006667564096764 4780 2743 An insecticide. SGTC_1679 SEC14.276 6.7 µM -3.22163116273701 0.0020510766044296 no 3337 0.000637315528241069 4772 1005053 YMR079W SEC14 SGTC_1722 st034304 3.6505 µM -3.27110985383269 0.00178166621617655 no 3338 0.000535631442070076 4779 4036148 YLR033W RSC58 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -3.33643636719721 0.00147528659872894 no 3339 0.000424299262292129 4778 676296 Flavone; oxidizing agent. SGTC_577 r071-0003 38.6 µM -3.33922033647793 0.00146336767456297 no 3340 0.00042006948781841 4798 4568517 YMR134W ERG29 SGTC_1909 st060837 51.5 µM -3.4010697565925 0.00122023111888375 no 3341 0.00033561348565912 4788 678937 SGTC_327 1273-0057 3.96 µM -3.45132500313175 0.00105054237631945 no 3342 0.00027892069086423 4791 3108138 SGTC_2250 alverine citrate 130 µM -3.63913848358635 0.000590403236986703 yes 3343 0.000136775835722112 4747 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_1193 1488-0126 41.5 µM -3.74526039884115 0.000421378275973891 yes 3344 9.01033813537388e-05 4802 1384710 SGTC_117 lucigenin 22.078 µM -3.78869341680004 0.00036615478668143 yes 3345 7.57208321668521e-05 4789 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_1951 sophoraflavanone G 9.2 µM -3.82887974538935 0.000321121498310915 yes 3346 6.43639421130841e-05 4784 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_2587 piperic acid 92.2 µM -3.90286456117569 0.00025139603879892 yes 3347 4.75304509475596e-05 4802 5370536 SGTC_2758 dehydroepiandrosterone 69.35 µM -3.91506807374437 0.000241351966199818 yes 3348 4.51893522578759e-05 4802 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_40 0327-0103 19.753 µM -4.09123708760101 0.000132308556392358 yes 3349 2.14539097864826e-05 4764 409036 SGTC_1718 roemerine 11.9335 µM -4.53218356414816 2.65080540672196e-05 yes 3350 2.91885430207149e-06 4718 235224 An aporphine alkaloid with mutagenic activity. SGTC_2582 agaric acid 100 µM -5.11205414984167 2.55331877180758e-06 yes 3351 1.59337221908202e-07 4759 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_299 1273-0059 1.44 µM -5.63157731685335 2.5191849976917e-07 yes 3352 8.92844450128002e-09 4794 2848077 SGTC_310 1273-0058 1.06 µM -8.53378908327273 1.2722015279254e-14 yes 3353 7.08154716053792e-18 4789 2734232