SGTCid condition conc unit ALG3|YBL082C.score ALG3|YBL082C.strain.pval ALG3|YBL082C.strain.significant ALG3|YBL082C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_1754 st042065 16.137 µM 10.5221718815495 1.74979016869499e-30 yes 1 3.4140592741071e-26 20 1126236 YIL048W NEO1 SGTC_625 k213-0058 121 µM 6.58624454999298 4.51087366486571e-13 yes 2 2.25545306410664e-11 26 3655420 SGTC_2021 4019055 173 µM 5.7189862847937 2.75908092248704e-10 yes 3 5.35807216975401e-09 44 44827708 YER133W GLC7 SGTC_2413 inermin 26.06 µM 5.50922410533569 1.14339874767275e-09 yes 4 1.80209404543758e-08 22 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_2688 kanamycin b 96.69 µM 5.36049659824874 3.03858579828505e-09 yes 5 4.14967449466018e-08 210 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_143 4032-1194 15.74 µM 5.26342034784762 5.67261927649738e-09 yes 6 7.06998916825535e-08 26 1806963 SGTC_3037 9091026 49.47 µM 5.16871064545961 1.03220006916312e-08 yes 7 1.17857256086109e-07 72 25236398 YIL048W NEO1 SGTC_513 4245-1575 41.7 µM 5.11027451684241 1.48575002985054e-08 yes 8 1.60845520238557e-07 69 719745 SGTC_2272 7805186 180 µM 4.82578672927502 8.27545817566507e-08 yes 9 6.97258378554963e-07 12 2956062 YPR165W RHO1 SGTC_410 α-linolenic acid 100 µM 4.81441626910444 8.84641555366135e-08 yes 10 7.38153932014382e-07 20 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2289 7946404 165.07 µM 4.36972442644799 1.07098227742552e-06 yes 11 6.22017141195106e-06 77 1246120 YPR165W RHO1 SGTC_2157 5649910 96.377 µM 4.28520668860841 1.67716033387686e-06 yes 12 9.12846868086928e-06 16 2858091 SGTC_2629 bisabolol 100 µM 4.098527840652 4.38896623327665e-06 yes 13 2.07893116248431e-05 17 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_2821 7996764 71.43 µM 4.00794884791756 6.90094284543456e-06 yes 14 3.06241907428946e-05 33 2987135 SGTC_3152 9099253 49.47 µM 3.83804497108488 1.57302069555579e-05 yes 15 6.20088864561887e-05 136 25236131 SGTC_2833 9001315 45.46 µM 3.7047932046064 2.93421830036541e-05 yes 16 0.000105781630766252 67 2989378 SGTC_2487 5918373 44.05 µM 3.65045958716624 3.76190707823581e-05 yes 17 0.000130885747940319 22 2876279 SGTC_3210 9128157 49.47 µM 3.58628655951199 5.0235921359918e-05 yes 18 0.000167710180996669 63 17590849 SGTC_708 3448-5400 146 µM 3.54345436518915 6.07764340662988e-05 yes 19 0.000197460826149871 59 3462195 SGTC_495 decylubiquinone 155 µM 3.52654331171004 6.54861717471005e-05 yes 20 0.000210511147982891 39 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_1597 7-benzyloxygramine 47.5 µM 3.47895666065132 8.06522205403566e-05 yes 21 0.000251684993598637 163 260807 SGTC_1281 0884-0031 11.8 µM 3.38251558442018 0.000122064946995127 yes 22 0.000359126012378686 43 1548255 SGTC_1991 st073000 8.92 µM 3.32237066091998 0.000157235490841769 yes 23 0.000446280200987786 112 4301969 YIL048W NEO1 SGTC_2623 humulene 100 µM 3.22649687622735 0.000233462310392229 yes 24 0.000626577999381546 51 6187145 An anti-inflammatory. SGTC_549 1661-1316 519 µM 3.22414561327937 0.0002357062436566 yes 25 0.000631745674778097 43 2857282 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 3.20942302614798 0.000250220541340826 yes 26 0.000665008264739338 36 688798 SGTC_255 tunicamycin 200.472 nM 3.02180796850003 0.00052469014343312 yes 27 0.0012563494777872 136 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2399 5884133 200 µM 3.00428400817262 0.000561146934779977 yes 28 0.00133103349808606 127 722445 SGTC_3014 9081533 49.47 µM 2.90008773589572 0.000830818043352419 yes 29 0.00186529111605463 39 21367265 SGTC_2941 9056145 11.23 µM 2.89318085415904 0.0008523536024272 yes 30 0.00190680818256835 49 2119517 SGTC_294 k038-0071 157 µM 2.88234307644986 0.00088718255897398 yes 31 0.00197364847281392 135 24152826 SGTC_439 amiodarone 34.4 µM 2.87771589147477 0.000902447481906175 yes 32 0.00200282857443325 167 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_800 3448-7362 155 µM 2.85361825330033 0.000985919418556613 yes 33 0.00216122187504604 299 15991913 SGTC_2639 lactacystin 53 µM 2.82104959249168 0.00111000923607315 no 34 0.00239334012063468 85 3870 A proteasome inhibitor. SGTC_3061 glucosamine 200 µM 2.82007836376844 0.00111392043386042 no 35 0.00240059615288673 51 91431 and experimental redox chemotherapeutic SGTC_2080 5212524 12.4 µM 2.77782458909259 0.00129681361926468 no 36 0.00273620758877192 60 260183 SGTC_188 3229-0966 278.469 µM 2.74540842560168 0.00145530411650432 no 37 0.00302178157760538 112 5722370 SGTC_831 k061-1017 217 µM 2.74401983767657 0.00146247242316512 no 38 0.00303459350786077 163 1240153 SGTC_429 1112-0049 25.5 µM 2.732524272582 0.00152306507785395 no 39 0.00314255201046781 111 2836170 SGTC_2273 7815444 169.05 µM 2.71425170011989 0.0016241048527609 no 40 0.00332128376687254 85 2824616 SGTC_1142 3253-1408 9.78 µM 2.69286788118349 0.00175008162169402 no 41 0.00354201673664822 67 256655 SGTC_3042 9091578 49.47 µM 2.69257853403184 0.00175184559216429 no 42 0.00354509175090077 46 25236497 SGTC_813 k007-0158 173 µM 2.67175200865161 0.00188314318654244 no 43 0.00377281950271682 134 6523916 SGTC_313 3474-0040 5.03 µM 2.65105907994331 0.00202239549581486 no 44 0.00401199021409429 181 1043375 YIL048W NEO1 SGTC_115 0527-0192 112.043 µM 2.62179884909028 0.0022352730126749 no 45 0.00437335193489841 187 4233931 SGTC_412 gemfibrozil 100 µM 2.60230940869066 0.00238812215020286 no 46 0.00462991341194876 56 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_1189 1431-2119 7.28 µM 2.59380253881175 0.00245775607153814 no 47 0.0047460492727944 133 3107275 SGTC_2896 9052656 71.43 µM 2.56504744478 0.00270694024239839 no 48 0.00515808488968332 269 6469436 SGTC_1887 st057648 70.8 µM 2.54829288016808 0.00286243579569356 no 49 0.00541257731630254 90 688672 SGTC_1250 0485-0349 40.2 µM 2.50044239935821 0.0033518551208237 no 50 0.00620191510379671 131 6842794 YDL195W SEC31 SGTC_2580 diallyl disulphide 81.36 µM 2.48544725518674 0.00352002121527998 no 51 0.00646943797765613 117 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_1100 amiodarone 5.07 µM 2.4762642756589 0.0036267089018286 no 52 0.00663826318641523 110 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 2.47435089177457 0.00364930051689896 no 53 0.00667392630466718 170 688788 SGTC_1717 st033143 58.0435 µM 2.47269963675428 0.00366889855776245 no 54 0.00670483969171701 163 674616 SGTC_1758 st042942 75.2445 µM 2.46943975635318 0.0037078661197105 no 55 0.00676624011887052 103 669317 SGTC_337 1315-0038 354 µM 2.45093083906265 0.00393623584167445 no 56 0.00712436639323758 120 1626437 SGTC_2925 9010536 32.5 µM 2.44958274259718 0.003953351344677 no 57 0.00715109225029854 177 2994177 SGTC_2249 haloperidol 116.36 µM 2.43705461300497 0.00411562535288241 no 58 0.00740372141197924 279 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_290 2043-6722 48.1 µM 2.40703699296215 0.00452893381354109 no 59 0.00804127034964672 132 773758 YLR208W SEC13 SGTC_1215 3852-0577 11.2 µM 2.40029799596494 0.0046266673683689 no 60 0.00819086483086539 126 2884876 SGTC_2391 6285546 200 µM 2.39012412650001 0.00477778296235238 no 61 0.00842133968820069 144 846083 SGTC_2621 lithochol-11-enic acid 100 µM 2.37981590025929 0.0049353676021382 no 62 0.00866064465739005 165 6708711 SGTC_2636 apigenin dimethyl ether 100 µM 2.36939151883222 0.00509942104729692 no 63 0.00890869055267168 193 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_1084 voriconazole 435 nM 2.36631921537237 0.00514868887538358 no 64 0.00898297314466137 138 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_43 0570-0105 72.5 µM 2.35983715905279 0.00525402802816485 no 65 0.00914147928059758 303 1114046 YDL195W SEC31 SGTC_404 fumagillin 50 µM 2.3445653932673 0.0055098225884139 no 66 0.0095246348612132 148 12015870 A methionine aminopeptidase binder. SGTC_1283 0922-0125 16.4 µM 2.33439723160818 0.00568621310321606 no 67 0.00978746580938309 132 3360884 SGTC_1270 0831-1170 17.3 µM 2.33187572354215 0.00573072292797507 no 68 0.0098536149681134 136 6764716 SGTC_146 3448-8650 53.125 µM 2.32802103153781 0.00579936400929439 no 69 0.00995549346286815 326 2891488 YIL048W NEO1 SGTC_1268 0828-0275 2.46 µM 2.32133295428071 0.00592019196758491 no 70 0.010134440489356 154 745337 SGTC_701 4424-0219 185 µM 2.31903165139378 0.00596228100121173 no 71 0.0101966600972137 143 2911779 SGTC_1508 1080-0625 72.9 µM 2.31308778081236 0.00607221975142574 no 72 0.0103589066972015 116 767111 SGTC_2604 4'-hydroxychalcone 11.32 µM 2.31027524870806 0.00612486412495697 no 73 0.010436460168213 175 5282362 SGTC_2374 9071832 200 µM 2.30785492679367 0.00617049049981064 no 74 0.0105036033625146 104 17381698 SGTC_1818 st052136 56.3 µM 2.30621751142595 0.0062015285139774 no 75 0.0105492407907216 195 674169 SGTC_632 0781-2353 4.65 µM 2.29388588401838 0.00643975641981918 no 76 0.0108985272267715 184 6811515 YHR007C ERG11 SGTC_1391 3442-0225 151 µM 2.2854683593454 0.00660698558882216 no 77 0.0111426898308573 129 5227075 SGTC_2132 5317594 122.667 µM 2.28140639588378 0.00668904859873814 no 78 0.0112622049617949 137 794577 SGTC_312 4092-0653 6.84 µM 2.27271803449877 0.00686760816805027 no 79 0.0115215885758276 238 1148278 SGTC_1152 3909-8331 15.9 µM 2.26260928634496 0.00708064631403442 no 80 0.0118298925874919 133 16001939 SGTC_504 lovastatin 124 µM 2.24614105077299 0.00744021015829643 no 81 0.0123474873282935 113 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_1094 duloxetine 25.4 µM 2.23151593835121 0.00777292102906014 no 82 0.0128234864790891 176 60834 A selective serotonin reuptake inhibitor. SGTC_1874 staurosporine 7.6 µM 2.2247087434796 0.00793219582061919 no 83 0.0130503984662326 187 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_496 calpeptin 138 µM 2.21924215160249 0.00806217398320332 no 84 0.013235127407527 153 73364 A calpain inhibitor. SGTC_2278 7948257 134.34 µM 2.21470163250616 0.00817155254818056 no 85 0.0133902753714634 151 1247028 SGTC_1998 st075797 76.8 µM 2.21357559556659 0.00819887908445218 no 86 0.0134289938274817 186 24208315 SGTC_108 0509-0257 621.132 µM 2.21247725431325 0.00822561081585424 no 87 0.0134668530667819 227 536624 SGTC_2811 7967822 32.47 µM 2.20618728961086 0.00838017729028149 no 88 0.0136854444285491 158 2232244 SGTC_507 nimesulide 162 µM 2.20091757218324 0.00851162981274032 no 89 0.0138709298505321 165 4495 A COX2 inhibitor. SGTC_663 1486-0733 13.9 µM 2.19858513130145 0.00857038763730868 no 90 0.0139537175852686 226 722445 YPR165W RHO1 SGTC_481 bay k-8644 50 µM 2.19345406546197 0.0087009010860728 no 91 0.0141373403211639 166 2303 A calcium channel antagonist. SGTC_1267 0828-0272 9.49 µM 2.18867639120767 0.0088239892567909 no 92 0.014310184556243 172 745334 SGTC_1249 0481-0015 10.2 µM 2.18630700495833 0.00888559640095182 no 93 0.0143965759983897 159 4227577 SGTC_953 1188-0045 9.7 µM 2.16760050440148 0.00938536662682424 no 94 0.0150945476752957 201 6144426 SGTC_830 4076-0286 57.8 µM 2.16755972797376 0.00938648234929736 no 95 0.0150961003263842 327 6866659 SGTC_676 falcarinol 140 µM 2.1581617397881 0.00964674456663816 no 96 0.015457629466559 205 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_2761 levamisole 97.89 µM 2.15059572854974 0.0098608337201138 no 97 0.015754061385839 159 26879 An alkaline phosphatase inhibitor. SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 2.13863087805905 0.0102078639730151 no 98 0.016232787348527 272 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_3098 9119039 49.47 µM 2.13297638970096 0.0103755418732296 no 99 0.01646333153418 193 17161528 SGTC_3019 9081971 49.47 µM 2.12296648425595 0.0106782677341059 no 100 0.0168783302412838 158 16451803 SGTC_2928 9011484 9.79 µM 2.11225590017836 0.0110106746394603 no 101 0.0173322530859635 176 2994751 SGTC_2050 5263056 171 µM 2.10960349309071 0.0110943706027193 no 102 0.0174462616113247 239 763468 YGL055W OLE1 SGTC_846 0335-0850 148 µM 2.10889310927965 0.0111168802879403 no 103 0.017476904565143 171 6819598 SGTC_3 0833-0587 95.581 µM 2.10202861687775 0.0113364471105731 no 104 0.0177753845444227 160 5382644 SGTC_3226 9131256 49.47 µM 2.10039501254647 0.0113892511538702 no 105 0.0178470536951501 60 17178073 SGTC_459 nigericin 15.3 µM 2.08119165317917 0.0120261733058252 no 106 0.0187081836240018 244 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_669 0108-0021 26.2 µM 2.07972543009523 0.0120760490038771 no 107 0.0187753621025087 330 17201 SGTC_2777 climbazole 1.536 µM 2.07044218528012 0.0123960132145056 no 108 0.0192054774207623 240 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_3018 9082602 49.47 µM 2.06883996199379 0.0124519735010787 no 109 0.0192805535179865 206 17332089 SGTC_2848 9016370 25.97 µM 2.06707320779955 0.0125139337938749 no 110 0.0193636281203684 209 7894410 SGTC_2448 5185112 27.17 µM 2.05752391743812 0.0128534695084576 no 111 0.0198179283459025 169 5718189 SGTC_1891 st059073 26.2 µM 2.05530942315636 0.0129333369820425 no 112 0.0199245638704141 208 688754 SGTC_407 eburnamonine 100 µM 2.05029391662772 0.0131158132849169 no 113 0.0201678789398527 178 3195 SGTC_994 3910-0338 138 µM 2.05021442481533 0.0131187232112434 no 114 0.0201717554853176 240 3479481 SGTC_286 k060-0067 22.9 µM 2.04987999052478 0.0131309718316819 no 115 0.0201880716305779 201 5985051 SGTC_2279 7948423 32.93 µM 2.04487154456189 0.0133155913243045 no 116 0.0204337619785392 160 1247112 SGTC_1596 piperlongumine 63 µM 2.03979879472313 0.0135048622522235 no 117 0.0206851849631314 194 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_2057 5236571 38.335 µM 2.01733327540502 0.0143712539947316 no 118 0.0218303726602805 273 54684039 YBR257W POP4 SGTC_1248 0469-0687 58.6 µM 2.01369798951615 0.0145158570956626 no 119 0.0220206256205425 225 4017482 SGTC_340 k038-0059 454 µM 2.01325067689998 0.0145337363734291 no 120 0.0220441321859747 228 23733424 SGTC_2810 7959871 45.46 µM 2.01189758964846 0.0145879352812371 no 121 0.0221153667743383 279 2974535 SGTC_875 0709-0210 25.7 µM 2.00210342489417 0.014985458399654 no 122 0.0226368046314444 244 6251364 SGTC_2114 5491910 81.25 µM 1.99767429336528 0.0151682626789416 no 123 0.0228759914692875 186 2849228 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 1.97641111096683 0.0160727703432605 no 124 0.0240541170775341 269 6728940 SGTC_1264 0783-0040 158 µM 1.96637358178586 0.016515570631291 no 125 0.0246277363899578 227 2855798 SGTC_56 0957-0365 83.25 µM 1.93632716328318 0.017903972038717 no 126 0.0264138219860012 272 6752360 SGTC_3012 9080433 71.4286 µM 1.932124051109 0.0181059128368579 no 127 0.0266720982127593 232 17688859 SGTC_3312 9133330 71.43 µM 1.9313239318451 0.0181445741748324 no 128 0.0267215028132141 214 17617324 SGTC_1219 1469-0211 33.1 µM 1.92117761612295 0.0186409737349093 no 129 0.0273546595535179 208 6822282 SGTC_3045 9092950 49.47 µM 1.91072963346542 0.0191641662471739 no 130 0.0280196672805722 251 44120432 SGTC_2742 clothiapine 36.27 µM 1.90900334752128 0.0192518022958044 no 131 0.028130829916376 183 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_984 1492-0255 2.91 µM 1.90509405811218 0.019451519703006 no 132 0.0283839228298036 241 1585198 SGTC_3296 9122258 64.045 µM 1.90365684983453 0.0195253848215609 no 133 0.0284774448176521 258 4730474 SGTC_1040 k898-0338 155 µM 1.90122080853609 0.0196511289466598 no 134 0.0286365483197639 278 20969351 SGTC_2754 granisetron 64.02 µM 1.89531317821083 0.0199589287795237 no 135 0.0290254616562181 277 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_996 3970-0799 1.8 µM 1.89170576996315 0.0201488863411523 no 136 0.0292650970704534 396 6615648 YGL040C HEM2 SGTC_1673 st016611 27.3 µM 1.89074624055754 0.0201996702610854 no 137 0.0293291132992363 307 5226799 SGTC_1055 3448-0672 86 µM 1.88976990664304 0.0202514549319727 no 138 0.0293943699801208 255 748378 SGTC_2205 7238770 200 µM 1.87668336390413 0.0209564993022044 no 139 0.030280752031981 192 279867 SGTC_1906 st060206 94.7 µM 1.85960785417524 0.0219075930864846 no 140 0.0314705136492944 264 5133468 SGTC_2164 5685496 200 µM 1.85773860530343 0.0220138885184884 no 141 0.0316030717033145 246 759046 SGTC_3164 9100705 49.47 µM 1.85752876026148 0.0220258485609644 no 142 0.0316179816623965 190 17174235 SGTC_2379 9035213 200 µM 1.85673137950105 0.02207134502472 no 143 0.0316746903710226 259 646551 SGTC_2828 7998861 71.43 µM 1.85194570409322 0.0223460730067502 no 144 0.0320168100194413 214 2988188 SGTC_1229 0139-0193 12.2 µM 1.85029778438517 0.0224413392257452 no 145 0.0321353209116609 282 3090752 SGTC_3297 9117502 71.43 µM 1.84513876345027 0.0227417995643126 no 146 0.0325086778245773 209 7453720 SGTC_445 e6 berbamine 66 µM 1.84496778670873 0.0227518149765607 no 147 0.0325211123661249 426 6610268 A calcium/calmodulin antagonist. SGTC_137 0438-0332 85.389 µM 1.83967912490499 0.0230634529565653 no 148 0.0329076800314737 433 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_422 cantharidin 155 µM 1.83067068917696 0.0236025561795933 no 149 0.0335748552607725 347 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2620 irigenin 100 µM 1.83046572169062 0.0236149445914193 no 150 0.033590163984694 311 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_2250 alverine citrate 130 µM 1.82995512295965 0.0236458294018326 no 151 0.0336283248459817 486 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_543 3844-1095 191 µM 1.82528624222834 0.023929816656312 no 152 0.033978922598626 314 4230703 SGTC_1088 bifonazole 369 nM 1.82276688396954 0.0240842450779422 no 153 0.0341693526836866 246 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_562 3772-2733 112 µM 1.82207187856628 0.0241269936867072 no 154 0.0342220400096675 349 2876874 YIL048W NEO1 SGTC_3257 9139206 32.98 µM 1.81957065751463 0.0242813673979145 no 155 0.0344122067632256 181 4910041 SGTC_2757 clomiphene 4.22 µM 1.81271714203138 0.0247086174613304 no 156 0.0349377295972991 332 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_1288 0973-0013 65.5 µM 1.79355630517319 0.0259366967794644 no 157 0.0364420080229099 278 4315430 SGTC_1143 3454-2408 5.08 µM 1.79105664684345 0.0261006109638378 no 158 0.0366421025967962 201 X1143 SGTC_852 0418-0143 439 µM 1.78991422681821 0.0261758126897362 no 159 0.0367338506857178 358 5369229 SGTC_1063 disulfiram 1.84 µM 1.78785558701475 0.0263117835233379 no 160 0.0368996549570485 289 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 1.78704297830318 0.0263656176914758 no 161 0.0369652712322168 261 756377 SGTC_2603 homopterocarpin 100 µM 1.76437196818391 0.0279050578013125 no 162 0.0388346872300223 338 101795 A weak amylase inhibitor. SGTC_129 0088-0017 176.636 µM 1.76348640454977 0.0279666790236307 no 163 0.0389092441429425 334 182446 SGTC_384 k007-0144 5.16 µM 1.75476661817467 0.0285795119819364 no 164 0.0396496178581674 369 6824886 SGTC_2 0422-0095 29 µM 1.75418056304479 0.0286210978716399 no 165 0.0396997863195483 203 6790840 SGTC_658 3253-0951 102 µM 1.75116068342681 0.0288361841190383 no 166 0.0399591178660192 404 1184878 SGTC_2124 5246320 200 µM 1.73391353766274 0.0300904861452513 no 167 0.0414667127403018 305 579342 SGTC_2462 5162487 171.77 µM 1.7324281096954 0.030200598196351 no 168 0.0415986833576835 304 2259986 SGTC_114 0364-0001 490.298 µM 1.72702691265259 0.0306037978012143 no 169 0.0420814151187222 345 4003655 SGTC_1713 st033146 12.748 µM 1.72595078150679 0.0306846613173575 no 170 0.0421781338712875 331 674619 SGTC_65 0798-0905 34.986 µM 1.72498441264448 0.0307574276865752 no 171 0.0422651408156581 445 3602145 SGTC_2166 5933061 31.504 µM 1.72334539968876 0.0308811699286067 no 172 0.042413041183844 326 2877375 SGTC_1139 k015-0024 46.9 µM 1.71523720807395 0.0314993984876177 no 173 0.0431508728256946 265 2766652 SGTC_1495 4469-0029 237 µM 1.71331285736745 0.0316476178516394 no 174 0.0433274991284021 466 793680 SGTC_2036 5160441 105 µM 1.71119767891417 0.0318111997859958 no 175 0.0435223135143409 398 134534 YIL048W NEO1 SGTC_254 nsc-64875 3.808 µM 1.7101020904532 0.0318962037232133 no 176 0.0436234981530916 293 56993 SGTC_2098 5376439 882.5 nM 1.70826285020272 0.0320393275167848 no 177 0.0437937906003661 335 2844116 SGTC_2691 st077356 60.2 µM 1.70245805068146 0.0324945201515652 no 178 0.0443347679286929 339 2839272 SGTC_3237 9133362 49.47 µM 1.69930168266389 0.0327442625489627 no 179 0.0446311778531552 320 43845137 SGTC_3048 9093155 49.47 µM 1.69750405811618 0.0328872025348585 no 180 0.0448007022654975 257 25236002 SGTC_2486 5283202 22.39 µM 1.69340766179385 0.0332148537699927 no 181 0.0451889487515908 334 1377751 SGTC_2216 7189485 200 µM 1.69332220180034 0.0332217178372541 no 182 0.0451970771786032 249 731273 SGTC_1509 1326-1131 80 µM 1.69170754539576 0.0333516252715826 no 183 0.0453508745292739 293 768313 SGTC_1060 3448-7350 82 µM 1.68962590488385 0.0335197209691457 no 184 0.0455497733752976 360 570178 SGTC_72 0744-0168 198.391 µM 1.68725437615495 0.0337120748189801 no 185 0.0457772248473411 327 677577 SGTC_2118 5526350 200 µM 1.68676023190798 0.0337522688142528 no 186 0.0458247325631588 348 743594 SGTC_3032 9089427 49.47 µM 1.68569045645905 0.0338394200940843 no 187 0.0459277180056938 302 17173707 SGTC_946 3434-1334 87.4 µM 1.68485128762743 0.0339079140620282 no 188 0.0460086334312718 326 4047976 SGTC_285 1486-1325 46 µM 1.68016262519498 0.0342927098238334 no 189 0.0464628394767431 353 22310230 SGTC_620 0109-0052 432 µM 1.68012145238694 0.0342961046825586 no 190 0.0464668439052332 313 493037 SGTC_1085 doxorubicin 7.67 µM 1.67900527439032 0.0343882432103022 no 191 0.0465755079148369 381 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_224 benfluorex 43.875 µM 1.66932971044862 0.0351954973632529 no 192 0.0475260276336686 215 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_2567 aureobasidin a 60 nM 1.66574481970877 0.0354985126333871 no 193 0.047882125440224 401 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_1294 1000-1494 117 µM 1.65733804270317 0.0362174956686166 no 194 0.0487255750272385 334 712797 YDL207W GLE1 SGTC_2149 5554786 194.827 µM 1.6562144499308 0.0363144870334624 no 195 0.0488391989936591 389 745063 YPR165W RHO1 SGTC_1672 st016598 6.51 µM 1.65618932070692 0.0363166586798871 no 196 0.0488417426195801 378 4665860 YNL267W PIK1 SGTC_3064 1327-0027 10 µM 1.65571114096735 0.0363580028325794 no 197 0.0488901650229372 184 16000455 YPR107C YTH1 SGTC_4 0960-0234 25.671 µM 1.65524123461095 0.0363986691779506 no 198 0.0489377869930521 321 6821112 SGTC_266 formosanin C 406 nM 1.65506507142369 0.0364139241740709 no 199 0.0489556495414886 382 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_1098 clofazimine 15.1 µM 1.6549522543542 0.036423696409136 no 200 0.0489670916729304 386 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_3313 9133968 57.047 µM 1.6513759113781 0.0367345939523921 no 201 0.0493309202047166 359 1494643 SGTC_2275 7947463 200 µM 1.64395889608497 0.0373862867876647 no 202 0.0500923465651766 324 1225414 SGTC_895 0964-0006 13.7 µM 1.63479516923234 0.0382044627745079 no 203 0.0510459969013437 331 6738897 SGTC_132 0417-1715 25.805 µM 1.62958648897187 0.0386759868142721 no 204 0.0515944609267341 360 6769098 SGTC_2514 salinomycin 42.74 µM 1.62541315964573 0.0390571961316294 no 205 0.0520372768763167 422 23682228 A polyether potassium ionophore. SGTC_2292 7671323 168.05 µM 1.62511723708533 0.0390843426704737 no 206 0.0520687903688995 377 937504 SGTC_1680 diphenhydramine 100 µM 1.62234234990156 0.0393396457492771 no 207 0.0523650327995445 366 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_289 k017-0060 526 µM 1.62095333331159 0.0394679507121614 no 208 0.052513823708265 300 5512909 SGTC_1999 st074831 12.5 µM 1.61462779303054 0.0400565591130626 no 209 0.0531956614674402 386 17112523 SGTC_768 0384-0033 77.3 µM 1.61410672351425 0.0401053623319534 no 210 0.0532521396336159 442 3965305 YMR134W ERG29 SGTC_63 0099-0242 26.702 µM 1.61322278026164 0.0401882626778863 no 211 0.0533480579942849 444 3898502 YLR359W ADE13 SGTC_1008 4106-0037 6 µM 1.61059666404666 0.0404353735656611 no 212 0.0536338306999087 331 2905394 SGTC_544 k015-0020 52.4 µM 1.60700591362246 0.0407752492865516 no 213 0.0540265354344975 338 3008304 SGTC_1525 8-methoxypsoralen 92.5 µM 1.60446741877664 0.0410169215314386 no 214 0.0543055302987586 423 4114 Related to psoralen; DNA damaging agent. SGTC_2598 perillyl alcohol 100 µM 1.59718135959936 0.0417170340021487 no 215 0.055112643280258 381 10819 An apoptosis inducer. SGTC_1624 st003710 6.25 µM 1.59617403687107 0.0418145840793248 no 216 0.0552249712645029 433 24207033 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 1.59594843674331 0.0418364567050978 no 217 0.0552501530219162 337 2374 Ca(2+)-ATPase inhibitor. SGTC_985 1493-0307 8.71 µM 1.58255980529086 0.0431512049755195 no 218 0.0567609155056185 308 3278274 SGTC_2333 9017922 200 µM 1.57433323048583 0.0439754638648021 no 219 0.0577052155796003 380 3163164 SGTC_1357 1503-1303 39.5 µM 1.57167639813206 0.0442443607382119 no 220 0.0580128092546652 421 292895 SGTC_1851 st056236 18.9 µM 1.57078113728959 0.0443352676758744 no 221 0.0581167474779237 369 5393171 SGTC_2641 levomentholum 100 µM 1.56716749669504 0.0447037365404876 no 222 0.058537772840916 304 16666 SGTC_964 1287-0107 19.4 µM 1.56660541577599 0.044761270751906 no 223 0.0586034755872795 420 51516812 YPR165W RHO1 SGTC_3308 9128332 17.569 µM 1.56368771385506 0.0450608834426231 no 224 0.0589454622260434 490 17332805 YDL196W YDL196W SGTC_943 3253-1379 105 µM 1.55423711218439 0.0460424409055639 no 225 0.0600639340329401 383 668464 SGTC_159 3970-0959 50 µM 1.55351214610984 0.0461184411316674 no 226 0.0601504148979972 616 6615653 SGTC_2521 angolensin 13.4 µM 1.54159787658133 0.0473819413311997 no 227 0.0615856709436477 361 821428 A flavenoid. SGTC_822 1487-0950 154 µM 1.53788200759814 0.047781632669193 no 228 0.0620387336554902 387 1958375 SGTC_1384 3089-0840 101 µM 1.53253401934319 0.0483616139962434 no 229 0.062695354666013 362 1069836 SGTC_112 phenothiazine 287.218 µM 1.5322249121045 0.0483953075985634 no 230 0.0627334715116133 399 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_206 4546-0025 72.014 µM 1.5298028667373 0.048659968042088 no 231 0.0630327659060416 479 6620745 YIL048W NEO1 SGTC_807 1315-0151 48 µM 1.52176360783469 0.0495467319572392 no 232 0.0640341615811416 460 4011080 SGTC_641 4092-0595 30 µM 1.52148485673799 0.0495777091990273 no 233 0.0640691043160484 426 786260 SGTC_2255 7941087 197.44 µM 1.5169364814256 0.0500853510181062 no 234 0.0646413608860284 461 935561 SGTC_3010 9080089 71.4286 µM 1.51523361092001 0.0502764704131419 no 235 0.0648566270703245 381 17027233 SGTC_3126 9127922 49.47 µM 1.51154387915075 0.0506925766504269 no 236 0.0653249689283315 434 45595682 SGTC_2300 7976697 71.57 µM 1.50998289019777 0.0508694393745498 no 237 0.065523895036167 349 2236109 SGTC_1591 genipin 88.4 µM 1.50863198888929 0.0510228950394541 no 238 0.0656964273205879 358 442424 A DNA cross-linking agent. SGTC_2158 5657123 3.6195 µM 1.50698321374153 0.0512106867117634 no 239 0.0659074799828012 380 2858827 SGTC_1187 1391-0724 117 µM 1.50666629994106 0.0512468453920777 no 240 0.0659481069012254 459 6997986 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 1.49913339676336 0.0521123160745261 no 241 0.0669195146049209 404 1609 A potent and irreversible inhibitor of serine proteases. SGTC_3215 9129942 49.47 µM 1.49850662965051 0.052184846708551 no 242 0.0670008357290331 360 17682944 SGTC_2522 biochanin a 4.94 µM 1.49646539239443 0.0524216182962231 no 243 0.0672662099294445 375 5280373 A possible chelator. SGTC_2454 5-benzylidenerhodanine 10.36 µM 1.49543776343734 0.0525411395808439 no 244 0.0674001155735828 445 1273210 SGTC_1197 1601-0112 267 µM 1.48543110267767 0.0537163317098255 no 245 0.0687148308341438 472 7350313 SGTC_644 1498-1197 63.3 µM 1.48217437356805 0.054103264022919 no 246 0.0691469517060063 464 6741615 SGTC_3147 9097027 49.47 µM 1.47878783300806 0.0545079554312644 no 247 0.0695985143381028 437 25236841 SGTC_2780 5215298 71.43 µM 1.47766511131624 0.0546426477730161 no 248 0.0697487185642806 468 2834131 SGTC_774 k060-0086 136 µM 1.47108772544673 0.0554370277745763 no 249 0.0706336970477134 500 5911235 SGTC_2412 st077135 33.4 µM 1.45883902969333 0.0569406316337404 no 250 0.0723047087367174 463 13258915 SGTC_2724 maprotiline 69.64 µM 1.45747169486091 0.0571104541762613 no 251 0.0724931095672693 421 4011 A tricyclic antidepressant. SGTC_2483 5729050 27.16 µM 1.45282845028597 0.0576901208463904 no 252 0.0731356953144227 554 2865180 SGTC_2529 gangaleoidin 93.61 µM 1.44871563788384 0.0582074228280105 no 253 0.0737085057532552 405 4565183 SGTC_2591 skatole 100 µM 1.44865161229448 0.0582155045612439 no 254 0.0737174499255633 437 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_2831 7999036 19.48 µM 1.44587664318856 0.0585666273410506 no 255 0.0741059020705847 486 2988270 SGTC_2468 5987765 72.9 µM 1.44393658767578 0.0588130927308394 no 256 0.0743784067919888 450 26772094 SGTC_998 3996-0085 177 µM 1.44003167745847 0.059311641371501 no 257 0.0749292185443557 500 715391 SGTC_2397 5161689 200 µM 1.4364060921649 0.0597774888038443 no 258 0.0754434103128033 487 2259942 SGTC_3202 9113761 49.47 µM 1.43283581025162 0.0602390267499244 no 259 0.0759523824276866 544 4798415 SGTC_1975 st070967 30.8 µM 1.42682883908457 0.061021849920448 no 260 0.0768146181850389 502 261391 SGTC_1263 0774-1208 64.8 µM 1.42562178866704 0.061180106954477 no 261 0.0769887717030718 540 906585 SGTC_1953 st076800 12.1 µM 1.42466781396257 0.0613054098641056 no 262 0.0771266235877612 500 297591 SGTC_2980 9014342 25.29 µM 1.42420050508889 0.0613668631888252 no 263 0.077194219369279 459 2996599 SGTC_1456 k015-0012 13 µM 1.42343614582512 0.0614674837619695 no 264 0.0773048802171098 529 2989616 SGTC_773 4358-1457 44.6 µM 1.42332156236223 0.0614825786773181 no 265 0.0773214795295833 525 1186886 SGTC_3168 9103419 49.47 µM 1.42089196347072 0.0618033294892152 no 266 0.0776740848479644 324 16649256 SGTC_746 1095-0025 46.6 µM 1.42068925497839 0.0618301495879056 no 267 0.077703558816155 486 6749286 SGTC_2372 9071633 200 µM 1.41658208229685 0.0623755233894871 no 268 0.0783025750845713 501 21321366 SGTC_1235 benzylparaben 21.5 µM 1.41203911248347 0.0629831263693114 no 269 0.0789692225143449 468 7180 SGTC_689 0833-0039 98 µM 1.40853427607276 0.063455026109668 no 270 0.0794864624288694 484 5374726 SGTC_2549 cedrol 20.94 µM 1.40677254836213 0.0636932664207307 no 271 0.0797474225986707 418 6708665 A sedative which affects the nervous system. SGTC_1375 2910-0797 186 µM 1.40393885828369 0.0640779284634848 no 272 0.0801685285730015 478 742508 SGTC_346 4513-0042 7.16 µM 1.40224816115397 0.0643082926118238 no 273 0.0804205772191888 508 2827372 SGTC_1146 3579-1023 7 µM 1.40122874748426 0.0644475024552562 no 274 0.0805728401856883 539 X1146 SGTC_1309 pyrazolanthrone 13.4 µM 1.39845221652426 0.0648278493847324 no 275 0.0809886561042358 507 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_1435 4092-0789 56.7 µM 1.39130423461776 0.0658150446805268 no 276 0.0820665951359081 472 2248285 SGTC_164 4100-3994 89.624 µM 1.39087443249521 0.0658747732428364 no 277 0.0821317535620496 547 4615967 SGTC_2190 6049624 200 µM 1.38087504474949 0.0672762536637633 no 278 0.0836586920957488 410 2265554 SGTC_1643 st009866 20.2 µM 1.37928212274008 0.0675016251789663 no 279 0.0839038931403311 441 3156273 YOR207C RET1 SGTC_2645 abamectin 100 µM 1.37866332993298 0.0675893310698102 no 280 0.0839992903267798 498 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_791 1348-1292 225 µM 1.37400824196808 0.0682519549733764 no 281 0.08471956185455 592 5437054 SGTC_2143 5623677 140.463 µM 1.37267016774816 0.0684433465120067 no 282 0.0849274536971656 446 5375313 SGTC_3158 9100007 49.47 µM 1.37039815238692 0.0687692724710883 no 283 0.0852813242658605 421 19297233 SGTC_2048 5246248 200 µM 1.36922697967647 0.0689377467352184 no 284 0.0854641674971877 447 677046 SGTC_1756 st041558 35.5 µM 1.36491877456614 0.0695602246646152 no 285 0.0861392903386832 546 3955792 SGTC_2342 7990637 118.86 µM 1.36332997480666 0.069790874155947 no 286 0.0863892696211858 531 2033102 YER133W GLC7 SGTC_3020 9089140 49.47 µM 1.36182395227915 0.0700100497116056 no 287 0.0866267252841314 496 17217859 SGTC_1834 st055981 52.8 µM 1.3604183487689 0.0702150884417291 no 288 0.0868487876296219 505 471719 YDL150W RPC53 SGTC_553 k007-0256 45.7 µM 1.35765404232368 0.0706196712924464 no 289 0.0872867430367574 526 6287000 SGTC_2125 5246583 200 µM 1.35491552868647 0.0710222434480574 no 290 0.0877222357670841 585 835267 SGTC_864 0469-0573 172 µM 1.3536175217073 0.0712136701437399 no 291 0.0879292169507203 489 689425 SGTC_1332 1480-0653 17.5 µM 1.35239452237956 0.0713943971268297 no 292 0.0881245703957912 521 5749438 SGTC_1679 SEC14.276 6.7 µM 1.34849571928242 0.071972887466762 no 293 0.0887494980333667 588 1005053 YMR079W SEC14 SGTC_278 4092-0821 23.9 µM 1.34635069445071 0.0722926874789635 no 294 0.0890947219988747 505 877900 SGTC_1969 st069479 40.1 µM 1.3458912320172 0.0723613297504241 no 295 0.089168798461127 443 3895485 SGTC_1061 3448-9325 110 µM 1.34545853572164 0.0724260188933636 no 296 0.0892386014697669 478 723482 SGTC_3314 9135860 59.4275 µM 1.3413009747658 0.0730498442843314 no 297 0.0899113767292754 528 25252478 SGTC_848 0368-0089 85.6 µM 1.3408300055278 0.0731207698425396 no 298 0.0899878258881119 528 762535 SGTC_686 1319-0111 510 µM 1.33766236178442 0.0735991705580362 no 299 0.0905032628034179 562 4562600 SGTC_454 lyso-paf C-16 6.67 µM 1.33542217291858 0.0739389423288496 no 300 0.090869105873583 497 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2438 5259590 200 µM 1.33472889299724 0.0740443353054256 no 301 0.0909825467725834 535 1201127 SGTC_2049 5262831 67.185 µM 1.3342835968156 0.0741120901012894 no 302 0.0910554656570661 520 763417 SGTC_2371 9071574 200 µM 1.33421324602325 0.074122798776274 no 303 0.0910669898215296 449 45596039 SGTC_709 3807-1509 243 µM 1.3322300442588 0.0744251648325175 no 304 0.0913923033717305 488 1886677 YPL242C IQG1 SGTC_1520 flindersine 88 µM 1.32814226785563 0.0750513716170548 no 305 0.0920655561323298 543 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_1465 k213-0056 144 µM 1.32541977524503 0.0754706544683513 no 306 0.0925159808265578 505 24048857 YMR208W ERG12 SGTC_260 nsc-65238 3.989 µM 1.32362706534137 0.0757477174804358 no 307 0.0928134659114875 511 3246252 SGTC_2704 st078022 71.1 µM 1.32302769239313 0.0758405230814909 no 308 0.0929130844049497 513 54697681 SGTC_714 4296-0578 26.1 µM 1.32091390487338 0.0761685086225915 no 309 0.0932650364251777 426 1589775 SGTC_2963 9082507 9 µM 1.31556252427191 0.0770036804872768 no 310 0.0941604594095457 502 16459611 SGTC_1498 4478-3555 97.6 µM 1.31202370495848 0.077559783391746 no 311 0.0947560682209466 471 3437919 SGTC_490 phenamil 164 µM 1.3104580574193 0.0778067857477927 no 312 0.095020462110334 405 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_3293 9120939 62.045 µM 1.3085359044425 0.0781108476036132 no 313 0.0953458023689251 526 934087 SGTC_986 1493-0483 84 µM 1.30798410119749 0.0781983026568885 no 314 0.09543935095148 518 40079 SGTC_329 k048-0121 21.3 µM 1.30698014764017 0.0783576092659369 no 315 0.0956097269558902 511 6832902 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 1.3065691844741 0.0784228915363622 no 316 0.09567953400872 582 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_391 gliotoxin 8.33 µM 1.30617119184168 0.0784861527094654 no 317 0.0957471735965745 576 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_1029 k015-0030 64.7 µM 1.30313036359832 0.0789707717850173 no 318 0.0962651295036543 530 2208316 SGTC_2625 euphol 100 µM 1.30278689165081 0.0790256533209027 no 319 0.0963237635966563 587 6708538 A triterpene alcohol. SGTC_2182 6325192 200 µM 1.30190488396147 0.0791667169151788 no 320 0.0964744513530839 521 736248 SGTC_884 0851-0618 334 µM 1.30050495713977 0.0793910050805286 no 321 0.0967139791912926 581 9642473 SGTC_2007 4011539 71.82 µM 1.29987710419337 0.0794917521270408 no 322 0.0968215467493564 550 45595301 SGTC_1343 1487-0095 224 µM 1.29565883047669 0.0801711382993507 no 323 0.0975465255232293 520 4560101 YGL055W OLE1 SGTC_3264 9137442 49.47 µM 1.29041269125013 0.0810221825226252 no 324 0.0984537039907048 512 17015726 SGTC_2766 oltipraz 83.91 µM 1.2893993876586 0.0811873464706379 no 325 0.0986296370987248 538 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_3262 9137218 49.47 µM 1.28609131211531 0.0817283165443562 no 326 0.099205597906489 382 17650664 SGTC_833 3852-0053 558 µM 1.28097777114491 0.0825698746998942 no 327 0.100100736988279 635 3123681 SGTC_1859 st055998 20 µM 1.28017173422266 0.0827031207701079 no 328 0.10024237225177 585 676301 SGTC_2909 7941780 10.49 µM 1.28004692636491 0.0827237672332339 no 329 0.100264316321585 561 1243215 SGTC_1434 4073-0095 163 µM 1.27227292904031 0.0840174470604466 no 330 0.101638081749778 587 24133745 SGTC_2453 5731132 22.18 µM 1.26880957509502 0.0845986549991221 no 331 0.102254494620738 606 1362040 SGTC_1278 0874-0585 172 µM 1.26711220102772 0.0848846012172124 no 332 0.102557586745813 575 766306 SGTC_3015 9080845 49.47 µM 1.25993047953689 0.0861024840778233 no 333 0.103847221157309 599 5296973 SGTC_447 ml7 120 µM 1.25853491359758 0.0863406549000925 no 334 0.104099184427962 570 4216 Selective myosin light chain kinase inhibitor. SGTC_1856 st057054 55.7 µM 1.25791690533983 0.0864462830118019 no 335 0.104210904577086 614 1266018 SGTC_2997 9067075 71.4286 µM 1.25743024464794 0.0865295295677736 no 336 0.104298941579752 614 27209819 SGTC_3263 9137018 49.47 µM 1.25321508344591 0.087253069963607 no 337 0.10506372104551 552 43844957 SGTC_2134 5324836 1.464 µM 1.25269682682415 0.0873423406122142 no 338 0.105158030617367 508 699272 SGTC_1134 3477-0009 42.5 µM 1.2504555496645 0.0877291898188708 no 339 0.105566591625879 636 3973534 SGTC_1032 k061-1018 98.7 µM 1.24703187438102 0.0883225889134284 no 340 0.106192905228403 668 4005393 SGTC_3135 9127742 49.47 µM 1.24637897335989 0.0884360899996358 no 341 0.10631264847177 549 3643468 SGTC_1903 st060211 78.3 µM 1.24429625233194 0.0887988789555425 no 342 0.106695274921305 624 688960 SGTC_184 1494-0393 24.714 µM 1.24344874184535 0.0889468235275984 no 343 0.106851259211984 607 3090647 SGTC_2770 toltrazuril 17.5 µM 1.24185278961569 0.0892259168402997 no 344 0.107145440707347 630 68591 Kills coccidiodes. SGTC_1560 lithocholic acid 53.1 µM 1.24045540259447 0.0894708205051146 no 345 0.1074034999352 499 9903 A bile acid which acts as a detergent. SGTC_1701 st028638 40.4 µM 1.23874691503916 0.0897709259882149 no 346 0.107719619276026 584 3490878 SGTC_3218 9131285 49.47 µM 1.23316980184665 0.0907557855051168 no 347 0.108756209724206 682 17156417 SGTC_1871 st057448 67.3 µM 1.23245129574242 0.0908832469140128 no 348 0.108890274723895 626 691747 SGTC_2935 9038016 29.96 µM 1.23025658083314 0.0912734069371774 no 349 0.109300518986573 617 6463195 SGTC_2827 7993847 71.43 µM 1.22613995610249 0.0920085766246066 no 350 0.110073006001092 538 2985692 SGTC_808 0711-0032 135 µM 1.22462194347707 0.0922807753966191 no 351 0.110358848099234 588 4252555 SGTC_18 0111-0177 500 nM 1.22291969797246 0.092586717825095 no 352 0.110680013918141 719 721752 SGTC_397 arbidol 50 µM 1.22175244078697 0.0927969407141122 no 353 0.110900629282257 629 131410 A RNA synthesis inhibitor. SGTC_1917 st066507 28.5 µM 1.22008833200991 0.0930972565224348 no 354 0.111215695621846 637 3156428 SGTC_988 1497-1057 103 µM 1.21567465594124 0.0938972551002737 no 355 0.112054441177266 620 3533044 SGTC_347 4534-1311 26.2 µM 1.21530024498428 0.0939653515089416 no 356 0.112125799259116 609 2862016 SGTC_989 1501-0895 10.3 µM 1.21272751206513 0.0944342560128264 no 357 0.11261700877747 603 2830112 SGTC_1044 1222-0021 1.78 µM 1.2119883338361 0.0945692966591656 no 358 0.112758423190425 617 4306703 SGTC_31 0508-1974 57.237 µM 1.20788366560099 0.0953217703449584 no 359 0.113546006716315 604 6810525 SGTC_2373 9071805 200 µM 1.20654231381596 0.0955686219684266 no 360 0.113804227011804 620 10149009 SGTC_2516 gossypol 71.55 µM 1.20509380537861 0.0958357218046612 no 361 0.114083545468332 662 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_604 1000-0114 314 µM 1.20415181598108 0.0960097157289868 no 362 0.114265452809814 658 1572745 SGTC_3323 9138564 53.9225 µM 1.20171584256158 0.0964607387977909 no 363 0.114736820475363 678 43912313 YNL103W MET4 SGTC_221 trifluoperazine 10.304 µM 1.20166296772943 0.0964705458621965 no 364 0.114747067221615 766 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_1630 st005209 31.3 µM 1.20015445248128 0.0967506494023576 no 365 0.115039680483086 709 3367314 SGTC_1973 st070275 50.2 µM 1.19979903145926 0.0968167314027742 no 366 0.11510870021564 573 17118334 SGTC_3354 9151612 71.43 µM 1.19579457025559 0.097563556244755 no 367 0.115888367670393 659 27261949 SGTC_568 1193-0097 7.48 µM 1.19251825449585 0.0981777186617168 no 368 0.116529048697087 644 3646150 SGTC_1022 4477-0945 21.3 µM 1.18971911695914 0.0987046710731179 no 369 0.117078404523924 636 4648966 SGTC_2180 6301957 200 µM 1.18925716540067 0.0987918345212511 no 370 0.117169242776908 625 845462 SGTC_2883 9059145 45.46 µM 1.18477852968421 0.0996398087236778 no 371 0.118052511845292 590 16476510 SGTC_715 0868-0130 184 µM 1.18190854495374 0.100185993574691 no 372 0.118620995538488 596 2876258 SGTC_292 k038-0015 474 µM 1.17074079753809 0.102332119142188 no 373 0.120851490515863 602 46368540 SGTC_1685 st024049 53.0905 µM 1.16938605781838 0.102594718756874 no 374 0.121124062273091 616 1941139 SGTC_2092 5303694 80.6725 µM 1.16862722246813 0.10274202351225 no 375 0.121276927710027 664 1963699 SGTC_1548 st061468 90.8 µM 1.16390791624211 0.103661584400174 no 376 0.122230665577011 663 390799 SGTC_2687 chenodiol 100 µM 1.1631507094476 0.103809680998169 no 377 0.122384180477947 616 5702181 A cholesterol synthesis inhibitor. SGTC_742 0kpi-0133 140 µM 1.16272738647727 0.10389254252963 no 378 0.122470063251291 666 2728852 SGTC_3124 9127567 49.47 µM 1.16240159389381 0.103956346053169 no 379 0.122536188080231 631 17592030 SGTC_2746 daunorubicin 9.88 µM 1.15875393638804 0.10467264757162 no 380 0.123278249299838 503 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_881 0833-0569 170 µM 1.15686453361468 0.105045077606172 no 381 0.123663855433846 658 5418700 SGTC_133 0724-0033 378.92 µM 1.15635362727762 0.105145949563289 no 382 0.123768270655695 613 280309 SGTC_2013 4024628 200 µM 1.15227127764667 0.105954476218325 no 383 0.12460480792246 592 5230760 SGTC_2987 9018338 71.43 µM 1.15212187437546 0.105984151156927 no 384 0.124635497777961 674 5055682 SGTC_1217 1183-1422 255 µM 1.1503407563517 0.106338384975074 no 385 0.125001775294655 712 2849664 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 1.14955283145273 0.106495362204951 no 386 0.125164047538154 467 4000243 SGTC_482 fipronil 114 µM 1.14941915403435 0.10652201117041 no 387 0.125191592840724 601 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_2818 7996756 12.99 µM 1.14698188990402 0.107008730870764 no 388 0.125694552897728 574 2241621 SGTC_3344 9148862 3.898 µM 1.14235534439179 0.107937056898089 no 389 0.126653172543648 668 4905352 SGTC_1316 1272-0050 65.9 µM 1.14132824938924 0.108143929978448 no 390 0.126866675322046 662 7340392 SGTC_1412 3909-8563 178 µM 1.13595407225826 0.10923102826464 no 391 0.127987893157253 748 23767530 SGTC_1428 4049-0204 61.7 µM 1.13389865580514 0.109648870450581 no 392 0.128418530520603 698 X1428 SGTC_2126 5251174 33.877 µM 1.12818369525623 0.110816683249086 no 393 0.129621174164914 776 790722 SGTC_1308 1187-1617 41.4 µM 1.12482516574348 0.111507118989874 no 394 0.130331564075694 721 2882570 SGTC_987 1497-1013 404 µM 1.12185141560902 0.11212101783994 no 395 0.130962810434582 648 1676435 SGTC_1494 4358-1428 177 µM 1.12184847301533 0.112121626501004 no 396 0.130963436111727 716 1564571 SGTC_882 0843-0131 351 µM 1.12157013599799 0.112179209825495 no 397 0.131022627629915 740 5425421 SGTC_1644 st010134 20.9 µM 1.1208194681933 0.112334615946437 no 398 0.131182357774872 655 3818134 SGTC_720 r052-1644 49.9 µM 1.12031509748395 0.11243911906847 no 399 0.13128975533712 610 1422863 YOR257W CDC31 SGTC_1801 st050089 28.441 µM 1.11861496296662 0.112791890140355 no 400 0.131652218618021 787 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_1789 tunicamycin 25 nM 1.11741060154777 0.11304226799714 no 401 0.131909402147843 688 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_960 1222-0186 7.7 µM 1.11461459564102 0.113625065688535 no 402 0.132507806501763 720 3126296 SGTC_700 3453-2283 142 µM 1.1090873203979 0.114783463266863 no 403 0.133696257126058 755 565664 SGTC_1712 st032288 53.4 µM 1.10874159908997 0.114856197182678 no 404 0.133770835368658 821 2883011 SGTC_1688 st021091 57.6 µM 1.10843828686285 0.114920035939762 no 405 0.133836288763768 693 3656366 SGTC_894 0960-0238 55.9 µM 1.10505834181358 0.115633128046172 no 406 0.134567154951247 711 6741907 YDL195W SEC31 SGTC_181 1447-1644 8.07 µM 1.10439501958613 0.115773442240274 no 407 0.134710910149055 703 534600 SGTC_1726 st035556 14.5795 µM 1.1025435840315 0.116165720637261 no 408 0.135112710706802 759 5919439 SGTC_1059 3448-6867 171 µM 1.10132509671748 0.116424405404915 no 409 0.135377596111316 711 3934407 SGTC_778 3456-2434 196 µM 1.10034499615382 0.116632777020872 no 410 0.135590917043994 800 5539063 SGTC_1203 3992-3522 103 µM 1.10020518022264 0.116662523746817 no 411 0.13562136703237 740 5322312 SGTC_3230 9131665 49.47 µM 1.09886564316831 0.116947791437144 no 412 0.135913337241354 581 15943720 SGTC_849 0386-0493 241 µM 1.09832561709831 0.117062935048694 no 413 0.136031164861033 679 726119 SGTC_1691 st019933 84.6 µM 1.09682814168602 0.117382644824341 no 414 0.136358262885019 693 6176082 SGTC_2709 st078560 56 µM 1.09573120927222 0.117617231033129 no 415 0.13659821029202 725 17250903 SGTC_2085 5307070 144.047 µM 1.0942153137172 0.117941961161216 no 416 0.136930278347027 656 2840351 SGTC_1860 st056228 74.6 µM 1.09151454185182 0.118522082199443 no 417 0.137523268348466 683 688679 SGTC_318 1488-0629 67.2 µM 1.09149842955109 0.118525549133727 no 418 0.137526811268531 676 3662576 SGTC_3265 9137266 49.47 µM 1.09127614023595 0.118573387138048 no 419 0.137575696636057 670 17224265 SGTC_1710 st031758 61.5 µM 1.08898832383877 0.119066532003938 no 420 0.138079517345479 692 5394341 SGTC_471 1-acyl-paf 4 µM 1.0877214517685 0.119340231729033 no 421 0.138359047312358 698 16759367 SGTC_2375 9072683 200 µM 1.08685364054729 0.119527972919317 no 422 0.13855074863938 801 16798029 SGTC_815 1582-0027 36.9 µM 1.08645427392117 0.119614441361988 no 423 0.138639030346086 725 3128206 SGTC_1360 1598-0022 39.8 µM 1.0856832451016 0.119781504646834 no 424 0.138809577965141 799 761525 SGTC_2875 9039966 71.43 µM 1.08528636016419 0.11986756412117 no 425 0.138897422556686 688 6463691 SGTC_2225 6654152 15.4 µM 1.08179126335807 0.120627314153827 no 426 0.139672644781414 645 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_1358 1509-0022 2.48 µM 1.08084656847111 0.120833248894429 no 427 0.139882684821275 729 3258434 SGTC_2286 7945697 125 µM 1.07901459008499 0.121233308106534 no 428 0.14029061181001 697 1245733 SGTC_1322 1348-1070 12 µM 1.0787401459378 0.121293320121737 no 429 0.140351791853457 688 6758089 SGTC_2009 4012297 12.05 µM 1.07589085392914 0.121917602138457 no 430 0.140988036403648 685 45595307 SGTC_621 3584-0052 32.1 µM 1.07529896702327 0.122047567616911 no 431 0.141120449273436 764 2273927 SGTC_1994 st072947 40.9 µM 1.07224517135892 0.122719660549597 no 432 0.141804963120475 746 5286565 YDL195W SEC31 SGTC_2490 carminic acid 95.39 µM 1.07113081328279 0.122965558721333 no 433 0.142055307552977 634 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_136 0097-0015 404.482 µM 1.07046846022699 0.12311187945225 no 434 0.142204249150939 790 4861337 SGTC_2648 atorvastatin 78.68 µM 1.07029837741833 0.123149472211162 no 435 0.142242512273065 717 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_3315 9136395 68.55 µM 1.06955902064176 0.123312982937726 no 436 0.142408924556927 795 16876844 SGTC_3186 9110464 49.47 µM 1.06717369051279 0.123841541849098 no 437 0.142946705322434 727 17018021 SGTC_2663 amphotericin b 100 µM 1.06668690329921 0.123949602276994 no 438 0.143056621541794 688 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_361 000s-0510 1.45 µM 1.06496426705733 0.124332534993355 no 439 0.143446050123579 728 660 SGTC_1431 4049-0260 9.09 µM 1.0637819393401 0.124595838391684 no 440 0.143713747416791 756 3854841 SGTC_716 1683-5115 658 µM 1.05677909446714 0.126163357176093 no 441 0.1453062087223 836 723597 SGTC_2396 5342950 42.78 µM 1.0567452947528 0.126170956098617 no 442 0.145313923522978 769 1886677 SGTC_1177 0983-0204 23.6 µM 1.05550557510192 0.126449892933872 no 443 0.145597080533723 792 766818 SGTC_343 4130-2827 29.8 µM 1.05088298702481 0.127493761266517 no 444 0.146656167522157 766 1118244 SGTC_101 0490-5701 117.494 µM 1.04969239773091 0.127763586664541 no 445 0.146929780063515 712 4661669 SGTC_635 k038-0028 24.7 µM 1.04824720141598 0.128091647067301 no 446 0.147262364278016 777 4035102 SGTC_1312 1218-2183 165 µM 1.04157517088478 0.129613785749698 no 447 0.148804342550762 791 6744073 SGTC_1885 st057546 99.9 µM 1.0398677651931 0.130005313796273 no 448 0.149200670192772 796 702008 SGTC_1183 1254-0324 198 µM 1.03830473899519 0.130364451006055 no 449 0.14956410155223 772 5799357 SGTC_1284 0929-0043 16 µM 1.03798071602013 0.130438987704783 no 450 0.149639516517202 774 1239883 SGTC_2839 9003951 25.97 µM 1.03663157825185 0.13074965375464 no 451 0.149953795297807 732 2990634 SGTC_2497 7-hydroxyflavone 100 µM 1.0362779047862 0.130831178713115 no 452 0.15003625554505 703 5281894 SGTC_1442 4112-3290 3 µM 1.03292387319851 0.131606060086639 no 453 0.150819762830458 798 704353 SGTC_2183 6420625 130.508 µM 1.03256126793729 0.131690022055669 no 454 0.15090463087784 820 2897619 SGTC_2347 9049783 174.81 µM 1.03094742296718 0.13206415937996 no 455 0.151282738076638 807 6467988 YPL169C MEX67 SGTC_3136 9095672 49.47 µM 1.03081929413831 0.132093894834064 no 456 0.151312784314305 684 17217380 SGTC_1010 4112-3296 15.2 µM 1.03026776183535 0.132221944209383 no 457 0.151442164066583 807 704384 SGTC_1976 st070609 63.5 µM 1.02942835020875 0.132416994771858 no 458 0.151639216363722 793 682556 SGTC_2115 tiliquinol 12.7705 µM 1.02842133081617 0.132651253161697 no 459 0.151875839434371 750 71208 A bioactive hydroxyquinoline. SGTC_2581 avocatin a 64 µM 1.02825051136142 0.132691018424626 no 460 0.151916001835477 781 6710728 A skin care supplement. SGTC_1137 ixabepilone 100 µM 1.02560560687552 0.133307776770695 no 461 0.152538761763257 812 154225 A novel microtubule stabilizer. SGTC_1472 k841-0093 193 µM 1.0211281800365 0.134356345860786 no 462 0.15359685676393 819 X1472 SGTC_1329 1447-1697 50.6 µM 1.02023345640632 0.134566558399546 no 463 0.153808876990685 777 2840515 SGTC_430 0958-0115 16.4 µM 1.01989494976405 0.134646148316534 no 464 0.153889142474856 746 6833180 SGTC_320 4092-0846 5.34 µM 1.0195012863999 0.13473874734534 no 465 0.153982521381373 800 1359356 SGTC_474 dl-dihydrosphingosine 5 µM 1.01924769163466 0.134798422030023 no 466 0.154042695171227 769 3058739 A sphingolipid protein kinase C inhibitor. SGTC_938 3126-1755 342 µM 1.01745930184881 0.135219772048359 no 467 0.154467491778215 830 1777771 SGTC_526 4469-0568 170 µM 1.01660140936495 0.135422214227167 no 468 0.154671541740533 758 2901964 SGTC_3320 9137005 35.139 µM 1.01543850009471 0.135696964563145 no 469 0.154948424268738 754 4908713 SGTC_2147 5545932 89.7195 µM 1.01443256361999 0.13593493611188 no 470 0.155188196300295 758 797404 SGTC_1516 st013856 110 µM 1.01378730022871 0.136087734590717 no 471 0.155342128244237 752 5281404 A mutagen and neurotoxin. SGTC_2849 9019321 12.99 µM 1.01360930138269 0.136129905427322 no 472 0.15538460879795 734 16489627 SGTC_2967 9089538 49.85 µM 1.01268952092747 0.13634795896506 no 473 0.155604242377217 798 728216 SGTC_1411 3909-8223 150 µM 1.01247126300707 0.136399736711714 no 474 0.15565639004329 839 X1411 SGTC_2227 7312221 64.1025 µM 1.01084786442417 0.136785280769571 no 475 0.156044625131793 817 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_2551 apiole 73.87 µM 1.00938336408291 0.137133726357565 no 476 0.156395406831149 654 10659 A possible DNA adduct former. SGTC_839 0122-0028 230 µM 1.00707570699592 0.137684012149833 no 477 0.156949197141019 837 759448 SGTC_3021 9087658 49.47 µM 1.00706472447135 0.137686634649557 no 478 0.156951835802017 790 25237042 SGTC_124 0136-0217 7.121 µM 0.99907917352801 0.139602520023665 no 479 0.158878169566103 932 3976905 SGTC_1507 4075-3230 155 µM 0.998796676389925 0.139670626846054 no 480 0.158946598202493 734 659771 SGTC_1540 guanosine 70.6 µM 0.995417868518566 0.140486969776604 no 481 0.15976653579703 770 6802 Guanosine is a purine nucleoside SGTC_2220 6782180 200 µM 0.995334663497319 0.140507113457425 no 482 0.159786762066106 714 833803 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.995214989095106 0.140536089701808 no 483 0.159815856597067 796 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_1955 wogonin 32.4 µM 0.991966550495336 0.141324169677468 no 484 0.16060692139333 787 5281703 A flavanone. SGTC_1799 st045822 46.1415 µM 0.99132814565558 0.141479399933763 no 485 0.160762686923088 806 3674992 SGTC_1633 st005664 67.9 µM 0.990743435487458 0.141621675488468 no 486 0.160905437912957 813 2063822 SGTC_1119 parthenolide 318.541 nM 0.987693420428941 0.142365396547157 no 487 0.161651408906042 876 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_1355 1499-0035 1.68 µM 0.985844334205408 0.14281756522662 no 488 0.162104753222501 794 1548538 SGTC_1354 1498-1681 81 µM 0.985462918999923 0.142910955721876 no 489 0.162198368490585 859 5754243 SGTC_3309 9129340 25.759 µM 0.983097026823191 0.143491172398991 no 490 0.162779843734656 872 17158987 SGTC_455 paf C-16 10 µM 0.980840060141452 0.144046156110144 no 491 0.163335809858211 797 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_1269 0831-0796 3.05 µM 0.97359786507094 0.145836762387532 no 492 0.165128123396655 835 927758 SGTC_2607 solasodine 47.35 µM 0.973172065013858 0.145942503520047 no 493 0.165233896070818 825 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_918 glabranin 770.725 nM 0.971180761436946 0.146437697961416 no 494 0.165729136190663 837 124049 Also referred to as licorice root. SGTC_2211 7117706 200 µM 0.967385063559923 0.147384727469981 no 495 0.166675787022097 801 822771 SGTC_1455 4262-0120 131 µM 0.967246527687176 0.147419369731686 no 496 0.166710403881993 870 1529587 SGTC_2850 9015429 58.44 µM 0.966590908622202 0.147583387751362 no 497 0.166874290607083 780 6457570 SGTC_535 2293-4129 48.2 µM 0.966033956315286 0.14772281803199 no 498 0.167013594972523 920 396118 YIL048W NEO1 SGTC_127 0180-0333 59.125 µM 0.965311299202166 0.14790386314804 no 499 0.167194457008288 897 771601 SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.964508927950505 0.148105052760413 no 500 0.167395417254684 851 94937 An inhibitor of serotonin biosynthesis. SGTC_1 0258-0098 57.368 µM 0.962805628512804 0.148532751313047 no 501 0.167822537798739 738 6790032 YDR047W HEM12 SGTC_863 0466-0191 129 µM 0.96229746991745 0.148660509742088 no 502 0.167950099772853 889 765160 YPR165W RHO1 SGTC_593 1203-0218 61.7 µM 0.960584944408715 0.149091604253842 no 503 0.16838045084644 887 3666956 SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.957770708989252 0.149801844362233 no 504 0.16908919618855 682 6708630 An antioxidant. SGTC_1432 4049-0298 68.4 µM 0.955604252455187 0.150350136820615 no 505 0.169636106136871 854 741646 SGTC_1198 1612-1005 86.7 µM 0.955413460081046 0.150398487036816 no 506 0.169684324921603 865 6998509 SGTC_2495 cafestol 54.53 µM 0.955221568232579 0.150447126327745 no 507 0.169732830442011 779 16667697 An anti-infammatory. SGTC_2978 9011784 42.97 µM 0.954505376431355 0.150628753731654 no 508 0.169913944565557 956 2994934 SGTC_1151 3909-8316 15.3 µM 0.953442461581075 0.150898579740672 no 509 0.170182968033012 851 800431 SGTC_1314 1222-0010 41.1 µM 0.951422357124636 0.151412279167343 no 510 0.170695007754969 864 3526027 SGTC_1186 1319-0216 26 µM 0.949425068205999 0.151921318705237 no 511 0.171202232826529 902 4565136 SGTC_743 1275-0778 158 µM 0.948656256663041 0.152117564738681 no 512 0.171397734364581 887 2849257 YMR203W TOM40 SGTC_1828 st055811 49 µM 0.945222954782481 0.152995999512839 no 513 0.17227253134068 829 5877589 SGTC_257 daunorubicin 18.5 µM 0.944831884560398 0.153096270536013 no 514 0.172372355496282 861 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1946 st076057 65.1 µM 0.944709644434654 0.15312762203097 no 515 0.172403565944641 735 953009 SGTC_1117 retinoic acid 1.10837 µM 0.944352591738849 0.153219221365486 no 516 0.172494749569401 916 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_2678 equilin 100 µM 0.940451635171657 0.154222349130519 no 517 0.173492973469372 895 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_332 4112-0506 40.9 µM 0.940135098121233 0.154303936467102 no 518 0.173574133748673 862 2790355 SGTC_3067 9117431 49.47 µM 0.939865763744821 0.154373379798113 no 519 0.17364321025682 820 17150885 SGTC_3173 9105693 49.47 µM 0.93923415526116 0.154536310438461 no 520 0.173805268227666 906 17096658 SGTC_35 0133-0054 64.071 µM 0.93780076825191 0.154906490552309 no 521 0.174173403111882 813 99677 SGTC_2179 6298986 200 µM 0.934248578430093 0.155826385382851 no 522 0.175087841278048 851 738374 SGTC_2880 9042983 58.44 µM 0.930886858261765 0.156700265566805 no 523 0.175956046578188 856 6464714 SGTC_3165 9101544 49.47 µM 0.930506915636537 0.15679923425978 no 524 0.176054342582004 881 5002184 SGTC_1346 1488-2224 62.4 µM 0.930455380330111 0.15681266151168 no 525 0.176067678100215 894 3722427 SGTC_1605 st000082 49.1 µM 0.929630792935439 0.157027606307872 no 526 0.176281139181082 892 1114022 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.928629919023282 0.157288763876883 no 527 0.176540455509417 858 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1452 4194-0072 190 µM 0.924722782553698 0.158310982786393 no 528 0.177555062759979 953 1343545 SGTC_592 k241-0073 46.5 µM 0.922790485206648 0.158818134490155 no 529 0.178058200109714 936 4230158 SGTC_642 0335-0876 158 µM 0.919887786872134 0.159581977319373 no 530 0.178815700880922 892 6812350 SGTC_2351 9026858 72.31 µM 0.917532905481012 0.160203426181666 no 531 0.179431729068258 820 1409300 SGTC_921 1561-0023 372 µM 0.916906681496199 0.160368951459588 no 532 0.179595771233471 897 24050882 SGTC_2022 5136654 200 µM 0.913797200440533 0.161192512805832 no 533 0.180411708882614 866 1713771 SGTC_2799 7812892 81.82 µM 0.913582055870213 0.161249596784683 no 534 0.180468249389676 908 20205235 SGTC_707 0865-0008 204 µM 0.912855323570396 0.161442517045248 no 535 0.180659318550183 954 723043 SGTC_2326 6164455 177.58 µM 0.909843692361243 0.162243596092331 no 536 0.181452474278313 838 2888790 SGTC_1656 st012921 11 µM 0.908563169208256 0.162584991709827 no 537 0.181790377660249 843 6732821 SGTC_916 4466-0038 42 nM 0.908287807694611 0.162658465855397 no 538 0.181863091218398 998 5722064 YGL116W CDC20 SGTC_1379 2144-0755 36.5 µM 0.908069984769341 0.162716602396716 no 539 0.181920623687932 962 5392327 SGTC_2436 5633522 8.09 µM 0.906372137059483 0.163170218034685 no 540 0.182369457681128 932 5724242 SGTC_2954 9074818 52.69 µM 0.906250283178642 0.163202805431786 no 541 0.18240169691296 869 16648742 SGTC_3214 9129694 49.47 µM 0.906050117725124 0.163256344880286 no 542 0.182454662990687 858 17158655 SGTC_1702 st027038 51 µM 0.905985402211019 0.163273657166075 no 543 0.182471789514022 903 5521182 SGTC_739 1486-1183 203 µM 0.903429214986765 0.163958426201563 no 544 0.183149070221937 935 4346692 SGTC_1315 1237-0019 3.69 µM 0.897978221774838 0.165424890051495 no 545 0.184598580082039 948 825140 SGTC_39 0986-0283 58.349 µM 0.89182397370344 0.167090714317753 no 546 0.186243644843027 981 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_823 0417-1665 178 µM 0.890958249811344 0.167325912189872 no 547 0.186475784330417 927 3429856 SGTC_349 k015-0014 24 µM 0.888502516282525 0.167994240616439 no 548 0.1871352514554 860 2196908 SGTC_1079 idarubicin 2.36 µM 0.888196325642213 0.168077690765603 no 549 0.187217577460295 902 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1070 indatraline 8.81 µM 0.887038329238581 0.16839353586982 no 550 0.187529132416603 923 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_2744 captopril 92.04 µM 0.886928385569783 0.168423542983011 no 551 0.187558729027597 881 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_218 alverine citrate 93.75 µM 0.886560327284044 0.168524022780746 no 552 0.187657830569428 891 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_2809 7964133 12.99 µM 0.885026333895294 0.168943217442158 no 553 0.188071214264543 900 1253665 SGTC_421 streptovitacin 30 mM 0.883788845710879 0.169281873771942 no 554 0.188405104401264 950 91467 include heat shock SGTC_370 0180-0345 38.7 µM 0.881526802608307 0.169902039692709 no 555 0.189016376818167 857 3989527 SGTC_1039 k821-0043 94 µM 0.880566739430754 0.170165692141809 no 556 0.189276183765274 959 15992768 SGTC_2492 derrusnin 100 µM 0.879446175657631 0.170473752634888 no 557 0.189579702391135 858 1715307 Part of coumarin class of compounds. SGTC_1751 st044839 27.194 µM 0.8774536666085 0.171022406031442 no 558 0.19012013732546 942 5291326 SGTC_3238 9133470 49.47 µM 0.876607178784561 0.171255834744674 no 559 0.190350019316818 939 3534688 SGTC_2532 xanthone 78.9 µM 0.875467479942279 0.171570441362534 no 560 0.190659798609877 856 7020 An insecticide. SGTC_2155 5570423 76 µM 0.874313837595256 0.171889272837211 no 561 0.190973682799754 866 797402 SGTC_855 0428-0020 25 µM 0.873429790162046 0.172133852392693 no 562 0.191214429706991 856 6812414 SGTC_5 0352-0601 109.883 µM 0.873217281616635 0.17219267786095 no 563 0.191272328507539 906 762456 SGTC_2257 7960413 200 µM 0.873079612621743 0.172230793495463 no 564 0.191309842709395 983 2974689 YIL048W NEO1 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.87235035603122 0.172432788418105 no 565 0.191508637161255 1007 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_78 0336-0123 156.75 µM 0.870356256501816 0.17298590009521 no 566 0.192052872084838 863 6765896 SGTC_640 3381-0960 37.1 µM 0.870280353234602 0.17300697600797 no 567 0.192073606486163 1009 1745025 SGTC_1748 st037455 53.6035 µM 0.870182599336506 0.17303412155295 no 568 0.192100311815118 916 580690 SGTC_1561 5-methoxyflavone 52.9 µM 0.868953055990814 0.173375788450259 no 569 0.192436403993832 924 94525 SGTC_3181 9108277 49.47 µM 0.867063804789975 0.173901612042309 no 570 0.192953525543196 945 17097298 SGTC_856 0433-0016 11.3 µM 0.86657157727869 0.174038777036339 no 571 0.193088396175594 949 3911780 SGTC_2215 7188065 200 µM 0.861505320850188 0.175454544127642 no 572 0.194479895954188 951 940217 SGTC_96 0929-0093 37.281 µM 0.860522976183288 0.175729903358479 no 573 0.194750411889145 913 6991579 SGTC_1554 st069299 38.7 µM 0.859099415558559 0.176129424575892 no 574 0.195142834870774 969 24207999 SGTC_2045 5106652 78.05 µM 0.856637637592964 0.176821676359951 no 575 0.195822589105812 980 673349 SGTC_512 prima-1 270 µM 0.855666972533724 0.17709509940005 no 576 0.196091006855994 1005 322968 A re-activator of the apoptotic function of mutant p53. SGTC_153 4077-0274 519.67 µM 0.855545979840847 0.17712920009489 no 577 0.19612448056751 931 3121976 SGTC_3328 9140624 29.0385 µM 0.853240069017727 0.177779892839271 no 578 0.196763093617437 996 4904392 SGTC_1086 cerivastatin 2.18 µM 0.853160360250332 0.177802412363653 no 579 0.196785191145464 953 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_2616 abietic acid 100 µM 0.851356858780943 0.178312423086824 no 580 0.19728557443111 1017 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_1631 benzylvanillin 81.9 µM 0.850813643018223 0.178466219100525 no 581 0.197436440880651 952 75506 SGTC_1797 st048695 56.8 µM 0.849926106521308 0.178717679421674 no 582 0.19768308503804 980 592262 YIL048W NEO1 SGTC_1020 4335-0961 93.3 µM 0.849590042126133 0.178812952700853 no 583 0.197776525070546 900 669075 SGTC_1487 3970-0795 2.82 µM 0.847868388239609 0.179301537865098 no 584 0.198255635667277 997 3765103 SGTC_1853 st056710 91.2 µM 0.846505742525646 0.179688835299657 no 585 0.198635335850554 1039 269167 SGTC_1546 5-methoxyflavanone 78.7 µM 0.845586316867698 0.179950455450343 no 586 0.198891780719304 1013 147795 SGTC_3322 9139058 2.11 µM 0.844821478080218 0.180168270475011 no 587 0.199105260414137 960 4908926 YPR165W RHO1 SGTC_2938 9059746 27.26 µM 0.844368165913439 0.18029744529918 no 588 0.199231852786211 919 6471769 SGTC_1978 st071761 42 µM 0.84407424867637 0.180381230348962 no 589 0.199313958282745 930 5147680 SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.843208354215593 0.180628207141045 no 590 0.19955596347134 1029 5282309 SGTC_2046 4110841 106 µM 0.843167245567078 0.180639937722683 no 591 0.199567457149504 1000 44119630 YMR134W ERG29 SGTC_1423 4048-0112 5.59 µM 0.842612488076116 0.180798287580226 no 592 0.199722602258233 1014 X1423 SGTC_528 3492-0019 172 µM 0.841061534649121 0.181241452905405 no 593 0.200156731288964 1077 2869262 SGTC_3195 9113082 49.47 µM 0.840346763657436 0.181445918489124 no 594 0.200356994374016 971 17018038 SGTC_11 0438-0307 1.3 µM 0.839397801349048 0.18171759926976 no 595 0.200623058621341 982 4011476 SGTC_3291 9121177 71.43 µM 0.837450091381895 0.182276010763107 no 596 0.20116980970882 891 17015612 SGTC_570 0987-0065 62.6 µM 0.837106195074424 0.18237471764094 no 597 0.201266439230397 889 3104428 SGTC_415 dibenzyl ketone 100 µM 0.836626621947111 0.182512422920992 no 598 0.201401238281776 986 7593 SGTC_3271 9137798 49.47 µM 0.835795649638199 0.182751183151919 no 599 0.201634937149847 918 6498326 SGTC_2493 resveratrol 26.09 µM 0.835590963293628 0.182810024847472 no 600 0.201692527129949 933 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_1653 st012112 65 µM 0.83533596619613 0.182883346042544 no 601 0.201764286183477 971 720429 SGTC_1449 4112-4002 201 µM 0.834649856326899 0.183080719383074 no 602 0.201957441121409 918 2059539 SGTC_57 miconazole 162.5 nM 0.834365080899025 0.183162679787948 no 603 0.202037644128211 951 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_1395 3486-0190 4.35 µM 0.834012528565342 0.18326417857039 no 604 0.202136961953047 1027 6748079 SGTC_721 1187-1332 279 µM 0.834000300341456 0.18326769966944 no 605 0.202140407300754 888 25730 SGTC_1510 1123-0200 71.5 µM 0.833098289238739 0.183527548762552 no 606 0.202394649174312 1040 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_1967 st070177 51.4 µM 0.831649764303959 0.18394531638373 no 607 0.202803331935881 995 5729214 SGTC_2364 9055074 200 µM 0.831454576762593 0.184001655466202 no 608 0.202858439269681 973 6470630 SGTC_1715 st032160 10.2275 µM 0.82885863665554 0.184751970974427 no 609 0.203592201757373 962 5289825 SGTC_2006 4011487 200 µM 0.827807370813426 0.185056363083577 no 610 0.203889799866966 1018 45595294 SGTC_2747 doxorubicin 7.63 µM 0.826138704233488 0.185540161771606 no 611 0.204362707154139 840 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2434 5670830 169.91 µM 0.82611306449631 0.185547601652083 no 612 0.204369978656046 959 1549830 SGTC_2568 diosmetin 100 µM 0.825518560791002 0.185720160655792 no 613 0.204538624772276 1011 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_1390 3413-2614 145 µM 0.823489279039627 0.186309923908154 no 614 0.205114905690611 1064 3421432 SGTC_2107 5363541 170.161 µM 0.822657235772064 0.18655207286364 no 615 0.205351470240217 1022 244052 SGTC_229 benomyl 22.8748 µM 0.820828048766478 0.187085104653211 no 616 0.205872109719739 1006 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_650 1328-0195 38 µM 0.820666726898605 0.187132159598912 no 617 0.205918064132481 1021 2780821 SGTC_617 3770-0098 35 µM 0.820452843797294 0.187194557079856 no 618 0.205979000605507 967 5962639 SGTC_3160 9100216 49.47 µM 0.819535839527417 0.187462226391823 no 619 0.206240381373069 1010 17191039 SGTC_2985 9022375 71.43 µM 0.819487958098761 0.187476209254953 no 620 0.206254034783094 1042 4939335 SGTC_2755 lomerizine 42.69 µM 0.819473025467623 0.187480570178526 no 621 0.206258292938896 1036 3949 A calcium channel blocker. SGTC_1462 k081-0014 26.5 µM 0.81917839356826 0.187566627259721 no 622 0.206342320170737 832 3270634 SGTC_667 1498-1044 59 µM 0.818567517674759 0.187745131707534 no 623 0.206516602893002 1035 6739982 SGTC_1920 st075728 45.7 µM 0.817734326007764 0.187988768289357 no 624 0.206754452768614 995 3400306 SGTC_2458 5808907 16.39 µM 0.816855083470388 0.188246082331888 no 625 0.207005624507224 1086 2731747 SGTC_1809 st050081 57.6 µM 0.81500336910166 0.188788704695313 no 626 0.207535190792916 1022 5036894 SGTC_1833 st055984 71 µM 0.814304424882533 0.188993772135469 no 627 0.207735287725507 994 676288 SGTC_3342 9147791 14.508 µM 0.813231696198591 0.189308773233107 no 628 0.208042614955485 1019 1838168 SGTC_1514 1189-1591 158 µM 0.812298073220776 0.18958318956184 no 629 0.20831030794659 1032 767698 YMR146C TIF34 SGTC_3233 9132340 49.47 µM 0.810773951731718 0.190031694455857 no 630 0.208747747938166 1024 17682950 SGTC_1587 estradiol valerate 56.1 µM 0.809943009324738 0.190276491248314 no 631 0.208986465597097 1040 13791 A steroid. SGTC_1184 1269-1718 139 µM 0.808836185262873 0.190602863871547 no 632 0.20930468964148 1049 5403821 SGTC_1475 4092-1048 11.7 µM 0.806990238991399 0.191147947679219 no 633 0.209836053408814 1046 2881759 SGTC_1804 st050076 49.1 µM 0.80498725859054 0.191740481596809 no 634 0.210413516210328 1005 3895976 SGTC_3060 1327-0027 12.5 µM 0.804885423058006 0.191770637222619 no 635 0.210442900474419 1000 16000455 YPR107C YTH1 SGTC_462 ag-879 158 µM 0.804793526540428 0.191797852191255 no 636 0.210469418940183 1074 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_3128 9127691 49.47 µM 0.803571164342205 0.19216007717768 no 637 0.210822341027285 923 41316314 SGTC_70 0141-0289 43.283 µM 0.80212237945678 0.192589940014811 no 638 0.211241085314331 1129 352408 SGTC_3056 9094900 49.47 µM 0.802034633295233 0.192615993669999 no 639 0.211266462349043 1015 25236784 SGTC_2306 7482397 179.52 µM 0.801518957358476 0.192769152075662 no 640 0.21141563688262 1026 891448 SGTC_1843 st055809 45.5 µM 0.800857495584738 0.192965718522104 no 641 0.211607074570841 979 16413835 SGTC_3261 9137475 49.47 µM 0.800714411363671 0.193008254925757 no 642 0.211648498794003 881 17027690 SGTC_2030 5175110 200 µM 0.800571661139319 0.193050697743356 no 643 0.211689831051608 1058 2831986 SGTC_2076 5212012 200 µM 0.800113396473644 0.193186988531955 no 644 0.211822550072924 945 604802 SGTC_940 3232-1287 54.8 µM 0.799743273624002 0.193297108254386 no 645 0.211929777682847 1043 1585493 YIL048W NEO1 SGTC_594 1487-1584 10.8 µM 0.799286873748164 0.193432950026472 no 646 0.212062044157242 1063 5013332 SGTC_2955 9076254 12.21 µM 0.799261405171207 0.19344053214837 no 647 0.212069426472484 1001 16459619 SGTC_398 bronopol 33.3 µM 0.79849853680445 0.193667725896719 no 648 0.212290620960276 1021 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_790 1575-0012 79.1 µM 0.797521336624518 0.193958988489835 no 649 0.212574158079417 1081 378741 YLR208W SEC13 SGTC_762 1165-0429 115 µM 0.797367875772791 0.194004753004467 no 650 0.212618705222046 1041 5967793 SGTC_2460 5552655 174.22 µM 0.797309071538409 0.194022291124254 no 651 0.212635776561663 1055 5401989 SGTC_1531 st059297 52.4 µM 0.796937758882521 0.194133055895067 no 652 0.212743590078758 1049 7566702 SGTC_3001 9076041 71.4286 µM 0.796579906238803 0.194239841905732 no 653 0.21284752557083 1038 16004211 SGTC_1111 tnp00062 510.699 nM 0.796032137265513 0.194403369696217 no 654 0.21300667816258 1088 676306 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.795921658148702 0.194436361648439 no 655 0.213038785942656 1049 6710655 SGTC_1374 2889-5571 141 µM 0.795136492652963 0.194670930761749 no 656 0.21326705447757 1045 2853281 SGTC_3054 9094397 49.47 µM 0.794448997797122 0.194876461971611 no 657 0.213467044615046 1090 2598354 SGTC_847 0342-0274 5.54 µM 0.794293395735296 0.194922998561865 no 658 0.213512323940192 1079 18097 SGTC_756 0508-1999 28.3 µM 0.794194615665424 0.194952544656379 no 659 0.213541071289322 1016 6753853 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.793426917995101 0.195182263421428 no 660 0.213764566433636 1114 5024745 SGTC_3343 9148379 18.9835 µM 0.79307893750514 0.195286444051682 no 661 0.213865916727876 1086 1955036 SGTC_1604 st002052 72.4 µM 0.79220850877813 0.195547186501962 no 662 0.214119554029224 1066 6254834 YHR062C RPP1 SGTC_2067 5224629 34.075 µM 0.792136895474241 0.195568648129629 no 663 0.21414042947316 1056 2835000 SGTC_42 0133-0086 60.653 µM 0.79204615020959 0.195595845425341 no 664 0.214166883629038 1034 162923 Model of phenazepam hydroxylation. SGTC_2479 5617353 43.85 µM 0.79117374777032 0.195857430621432 no 665 0.214421304312138 1035 2731746 SGTC_3154 9100113 49.47 µM 0.789745737174451 0.196286069823724 no 666 0.21483813732617 1066 25237525 SGTC_390 dec-rvkr-cmk 16.7 µM 0.785387943061576 0.197597639988271 no 667 0.216113073852897 1095 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_2517 totarol 10 µM 0.784660929641822 0.197816964514808 no 668 0.216326197971397 1038 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_965 1291-5240 308 µM 0.784390096085507 0.197898706841551 no 669 0.216405623971693 1053 2834598 SGTC_587 k089-0003 57 µM 0.783626752788025 0.198129207039102 no 670 0.216629576636996 1004 9659696 SGTC_2707 st078556 66.6 µM 0.781923433960692 0.198644127605053 no 671 0.217129786069048 1039 17250899 SGTC_287 k060-0039 29.6 µM 0.781606228210599 0.198740109325476 no 672 0.217223012749983 1091 5861974 SGTC_3268 9137683 49.47 µM 0.780718390146141 0.199008904481914 no 673 0.217484070995121 1045 1953228 SGTC_865 0488-0499 301 µM 0.780592044488677 0.19904717373776 no 674 0.217521236150781 1107 9634651 SGTC_207 4185-0010 4.486 µM 0.780461942949808 0.199086585258415 no 675 0.217559509946852 1144 3761753 SGTC_2842 9000675 19.48 µM 0.779809984118769 0.199284153252913 no 676 0.2177513643594 1057 2989072 SGTC_3306 9127676 59.7925 µM 0.77925321244803 0.199452969399923 no 677 0.217915284921723 1061 41905287 SGTC_873 0591-4978 488 µM 0.778907024221606 0.199557978911734 no 678 0.218017242944133 1128 3305145 SGTC_1182 1222-0449 220 µM 0.777482251273193 0.199990506410177 no 679 0.218437150982858 1029 658318 SGTC_1178 0988-0033 191 µM 0.776892755911523 0.200169628039038 no 680 0.218611022758316 1080 5392207 SGTC_1344 1488-0097 29.1 µM 0.775586377805678 0.200566922149791 no 681 0.2189966230381 1050 747966 SGTC_2995 9067767 71.4286 µM 0.775010891763502 0.200742088391727 no 682 0.21916661182054 1029 11673567 SGTC_3345 9148410 3.559 µM 0.774323338723865 0.200951485892635 no 683 0.219369802706944 1055 4903596 SGTC_2222 6885208 172.143 µM 0.774124755111352 0.201011989844577 no 684 0.219428509782778 1036 609514 SGTC_149 3970-0822 46.1 µM 0.773381765710824 0.20123845888309 no 685 0.21964823904943 1158 3114250 YBL034C STU1 SGTC_1405 3909-7894 12 µM 0.772219465891213 0.201593043736185 no 686 0.219992227118103 1097 7104060 SGTC_186 3455-3465 67.277 µM 0.772069188105507 0.201638916554822 no 687 0.220036725085947 1024 755278 SGTC_1135 dihydrocapsaicin 536.708 nM 0.770863211940914 0.202007271368001 no 688 0.220394007307647 1023 107982 A Capsaicinoid. SGTC_3106 9121286 49.47 µM 0.770479824620387 0.20212445797103 no 689 0.220507659169067 1078 15943471 SGTC_2026 5148700 152 µM 0.769918888113266 0.202295987737091 no 690 0.220674004454077 1091 79838 SGTC_896 0964-0007 44.5 µM 0.769913822877971 0.202297537040896 no 691 0.220675506873055 1107 6756758 SGTC_1326 1431-2094 10.8 µM 0.769635679395357 0.202382623698083 no 692 0.220758017078396 1077 616278 SGTC_2798 7813637 45.45 µM 0.769062447441103 0.202558048130122 no 693 0.220928119870209 1055 956368 SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.769005187663447 0.202575576157604 no 694 0.220945115451345 1041 77254 SGTC_2507 purpurin 79.67 µM 0.768272423367999 0.202799965698876 no 695 0.221162677206001 1114 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_2117 5521686 200 µM 0.76520369093568 0.203741295146908 no 696 0.222075131091529 1082 803312 SGTC_3189 9110682 49.47 µM 0.76422741398222 0.20404131206014 no 697 0.222365866272604 1093 17122418 SGTC_1036 k216-0215 33.5 µM 0.763821334298964 0.204166180726728 no 698 0.22248686067052 1080 622330 SGTC_1779 st039427 55 µM 0.762684774210883 0.204515912485965 no 699 0.222825706541113 1151 1124498 SGTC_2993 9054257 71.4286 µM 0.762281911691505 0.204639963146196 no 700 0.222945883630591 1149 6470217 YGL055W OLE1 SGTC_3278 9139605 49.47 µM 0.758308429560913 0.20586588632094 no 701 0.224133181036968 1113 7958859 SGTC_1795 st049545 62.3 µM 0.757914987885893 0.205987509981665 no 702 0.22425093855973 1089 5291882 SGTC_643 k048-0106 28.4 µM 0.757710486383728 0.206050743858656 no 703 0.224312159954414 1085 6763920 SGTC_2976 9009005 19.48 µM 0.757525697025031 0.20610789244609 no 704 0.224367488305471 1114 2993148 SGTC_2435 5706476 10.6 µM 0.75610009906978 0.206549093569034 no 705 0.224794591292555 1136 5725375 SGTC_2491 paeonol 100 µM 0.755440981204816 0.206753269607277 no 706 0.224992215893673 1083 11092 Increases levels of cortical cytochrome oxidase. SGTC_3244 9134489 49.47 µM 0.755236281623451 0.206816704047363 no 707 0.225053611402696 1095 16584271 SGTC_1499 4480-0877 67.3 µM 0.754754289428414 0.206966114307974 no 708 0.225198212723388 1058 2861909 SGTC_874 0599-0792 117 µM 0.754667402212919 0.206993054818652 no 709 0.225224285145725 1156 765305 SGTC_1552 6-methylflavone 10.6 µM 0.754489791291888 0.207048131849503 no 710 0.225277586532965 1082 689013 SGTC_1175 0741-0056 27.6 µM 0.753981693605278 0.207205740485079 no 711 0.225430107093499 1175 765927 SGTC_531 3788-1495 174 µM 0.750522065918937 0.208280779776749 no 712 0.226470169568193 1039 2896655 SGTC_534 k292-0788 63.4 µM 0.750462112092691 0.208299438694492 no 713 0.226488217245263 1166 4146317 SGTC_2165 5727197 32.143 µM 0.749629768124664 0.208558583867189 no 714 0.22673885853102 1182 1361712 SGTC_983 1491-0821 12.2 µM 0.748580623745208 0.208885499164273 no 715 0.227055007139687 1093 46495113 SGTC_261 5-fluorouridine 15.376 µM 0.748208518537466 0.209001520310609 no 716 0.22716719680485 1108 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_296 1222-0039 74.9 µM 0.748111799466317 0.209031683203759 no 717 0.227196362705987 1087 5984176 SGTC_677 0929-0063 136 µM 0.747895886545027 0.209099027242916 no 718 0.227261479453578 1063 1539583 SGTC_759 3486-0358 89.3 µM 0.747698164667225 0.209160708633329 no 719 0.227321119224924 1147 875103 SGTC_703 3875-0075 71.8 µM 0.747686812629512 0.209164250344381 no 720 0.227324543660628 1160 2850814 SGTC_2232 chlorophetanol 41.5365 µM 0.747634888314042 0.209180450610462 no 721 0.227340207428707 1194 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_483 fpl-64176 144 µM 0.746020032927044 0.209684650381965 no 722 0.227827656823144 1123 3423 SGTC_2585 alliin 100 µM 0.745734321893484 0.209773931130025 no 723 0.227913960828695 1154 87310 A garlic compound which reacts with lipids. SGTC_1629 st005085 44.9 µM 0.745729930385712 0.209775303589868 no 724 0.227915287503797 1114 24207091 SGTC_305 1682-2595 20.8 µM 0.744646904448132 0.21011393838981 no 725 0.228242602419621 1122 226033 SGTC_1064 honokiol 6.76 µM 0.74004055360422 0.211557810832436 no 726 0.229637693820466 1119 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_1470 k295-0292 231 µM 0.739525271062766 0.211719687927376 no 727 0.229794050133006 1139 5045612 SGTC_2338 7999974 200 µM 0.736921753010145 0.212538696287754 no 728 0.230584967319811 1194 315925 SGTC_3249 9135183 49.47 µM 0.736425833645096 0.212694910950635 no 729 0.230735793894724 1181 4902779 SGTC_2304 7443016 91.4 µM 0.736178864753142 0.212772731182772 no 730 0.230810926398828 1055 939854 SGTC_794 k038-0031 316 µM 0.734997331906674 0.213145263692948 no 731 0.231170559522819 1170 6624242 SGTC_693 4161-2696 114 µM 0.734979867354683 0.213150773046999 no 732 0.231175877699801 1115 805759 SGTC_2297 7971671 152.32 µM 0.73487739550863 0.213183100409592 no 733 0.231207083048355 1131 909016 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.734643420899733 0.213256924396892 no 734 0.231278343224889 1158 551469 SGTC_461 N-acetylfarnesylcysteine 136 µM 0.732515477197781 0.213929020089734 no 735 0.231926999769714 1183 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_252 miconazole 1.30953 nM 0.731901868987308 0.214123052646717 no 736 0.232114232674088 1093 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_3059 1327-0034 3 µM 0.731728232782351 0.214177977727199 no 737 0.232167230302534 1117 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_3084 9116877 49.47 µM 0.73002841599202 0.214716101206701 no 738 0.23268640768493 1064 27241325 SGTC_131 0141-0277 33.849 µM 0.726894359797882 0.215710329418893 no 739 0.233645336296021 1095 1547771 SGTC_2676 harmalol 100 µM 0.726831675923461 0.215730242041045 no 740 0.233664538033557 1149 5459187 A monoamine oxidase inhibitor SGTC_2991 9074669 71.4286 µM 0.726746101852186 0.215757427852274 no 741 0.233690753059451 1152 17333109 SGTC_1745 st081495 74 µM 0.726580577382931 0.215810018539275 no 742 0.233741464964471 1131 13842402 YBL026W LSM2 SGTC_2948 9070189 9.45 µM 0.726391736013518 0.215870026579622 no 743 0.233799327941211 1057 6473636 YDL196W YDL196W SGTC_1738 st035555 74 µM 0.725870115956456 0.216035831793245 no 744 0.233959199040873 1162 5331140 SGTC_2339 9000433 200 µM 0.723943514191565 0.216648871797659 no 745 0.234550206970444 1124 2988954 SGTC_646 4092-0839 27.3 µM 0.723196305650819 0.216886902276199 no 746 0.234779644104347 1184 877796 SGTC_1185 1319-0113 81.3 µM 0.722280593143327 0.217178817381246 no 747 0.235060991017974 1146 4672763 SGTC_2276 7947513 42.08 µM 0.719932846449043 0.21792827909472 no 748 0.235783171584334 1079 2105100 SGTC_195 4234-0266 16.654 µM 0.71915329613863 0.218177461221676 no 749 0.236023236067516 1150 2303354 SGTC_2693 st077581 40.7 µM 0.718114318133482 0.218509824151421 no 750 0.236343401229002 1186 25238761 SGTC_1527 coumarin 137 µM 0.717844449223974 0.218596201296838 no 751 0.236426601498617 1129 323 A hepatotoxic, DNA x-linker. SGTC_975 1335-0046 28.5 µM 0.716558157790307 0.219008175607927 no 752 0.236823385112077 1159 16486740 SGTC_713 1488-1073 324 µM 0.716212095380032 0.219119088898416 no 753 0.236930197805835 1147 3312542 SGTC_1114 scopoletin 1.73284 µM 0.714779877942346 0.219578459056762 no 754 0.237372535387316 1187 5280460 A coumarin with genotoxic properties. SGTC_3311 9131146 2.8755 µM 0.714341308415011 0.219719236612702 no 755 0.237508077366073 1123 4900406 YPR165W RHO1 SGTC_3144 9087057 49.47 µM 0.709871495824565 0.221156965532072 no 756 0.238891913948815 1116 17249618 SGTC_1729 st035615 45.989 µM 0.709599355343343 0.221244673835611 no 757 0.238976309752935 1114 17385451 SGTC_1556 plumbagin 1.48 µM 0.708997748440111 0.221438636644217 no 758 0.239162937035921 1105 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_3188 9110789 49.47 µM 0.708483757979802 0.221604428206267 no 759 0.239322447486231 1197 849217 SGTC_3253 9135987 49.47 µM 0.707308311373126 0.221983844017721 no 760 0.239687450819312 1166 4182430 SGTC_2239 6685329 187.64 µM 0.7068757729738 0.222123553959014 no 761 0.239821840412283 1171 805680 SGTC_2768 sulfasalazine 50.2 µM 0.706520881852736 0.222238221295076 no 762 0.239932135704353 1208 5384001 An antioxidant and salicylic acid derivative. SGTC_2699 st077704 54.6 µM 0.705816997232035 0.222465750316598 no 763 0.240150975212694 1170 645852 SGTC_1620 st003704 16.5 µM 0.705467802940906 0.222578675818527 no 764 0.240259580961452 1167 2834414 SGTC_1200 1643-0193 18.4 µM 0.704589791299179 0.222862759245323 no 765 0.240532776692319 1192 5403974 SGTC_3200 9114385 49.47 µM 0.704004734990429 0.223052170683472 no 766 0.240714912433372 1175 17018030 YLR208W SEC13 SGTC_1794 st048918 76.9 µM 0.702295693455078 0.223605996017722 no 767 0.241247389207567 1129 672303 SGTC_2557 derrustone 83.84 µM 0.700832299800943 0.22408083851254 no 768 0.241703839058694 1190 629853 An antioxidant. SGTC_8 0354-0001 70 µM 0.699064190246218 0.224655318669712 no 769 0.242255958186435 1225 4993152 SGTC_3073 9114972 49.47 µM 0.697813952856513 0.225062039599915 no 770 0.242646776034273 1112 41905075 SGTC_1640 st009078 66.4 µM 0.697191778064907 0.22526459775005 no 771 0.242841391843014 1171 690618 SGTC_2790 5423970 71.43 µM 0.697186752644827 0.225266234269674 no 772 0.242842964134466 1209 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_1714 st033236 13.627 µM 0.696420336295789 0.225515895274712 no 773 0.24308281550045 1221 2916566 SGTC_2748 diazoxide 86.69 µM 0.695913220097382 0.225681175016588 no 774 0.243241588822138 1137 3019 A potassium channel activatior. SGTC_1011 4112-3381 17.4 µM 0.694646963539376 0.226094173495868 no 775 0.243638286496035 1241 2877139 SGTC_2722 naftopidil 47.16 µM 0.694570460912952 0.226119139041189 no 776 0.24366226471578 1181 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_1989 st071868 50.2 µM 0.693659062506568 0.22641668077445 no 777 0.243948022324051 1199 16414057 SGTC_2262 9014885 67.46 µM 0.692808154364753 0.226694673884212 no 778 0.244214977086356 1142 6457424 SGTC_2381 9035592 200 µM 0.692660654050024 0.226742882064087 no 779 0.244261268259518 1156 4749657 SGTC_1837 st055472 66.5 µM 0.692352226453851 0.226843705510978 no 780 0.244358079779888 1256 676091 SGTC_1832 st054113 55 µM 0.691139995485984 0.227240222733199 no 781 0.244738784023375 1192 1251267 SGTC_1422 4031-0024 15.5 µM 0.690910336778798 0.227315387413847 no 782 0.244810944891094 1165 782427 SGTC_733 4069-0007 56.1 µM 0.690313405853075 0.227510821623253 no 783 0.2449985596086 1229 5717425 YNL287W SEC21 SGTC_3285 9112818 20.8695 µM 0.687690250251727 0.228370759154088 no 784 0.245823930504978 1255 17017947 YPR165W RHO1 SGTC_169 k015-0017 16.025 µM 0.686233061783657 0.228849250888058 no 785 0.24628307612422 1252 1840002 SGTC_225 nsc-122657 1.016 µM 0.684496201910126 0.229420311671665 no 786 0.246830943450493 1149 275685 SGTC_2917 7979103 53.79 µM 0.682102791055021 0.23020854629669 no 787 0.247586977944526 1220 2980565 SGTC_868 0527-0199 213 µM 0.681321467579819 0.230466191271494 no 788 0.247834051227405 1170 2849450 SGTC_1212 0520-0165 585 µM 0.680368268069717 0.230780731303788 no 789 0.248135653994478 1341 5403258 SGTC_102 gallobenzophenone 83.616 µM 0.68010853172658 0.230866481540131 no 790 0.248217871346635 1263 70837 SGTC_2907 7721985 69.9 µM 0.679538875167939 0.231054612173917 no 791 0.248398242190677 1188 3267881 SGTC_2934 9036370 36.88 µM 0.678251833704495 0.231479976017153 no 792 0.248806016314351 1220 6462800 SGTC_1333 1482-0047 286 µM 0.677117704972615 0.231855164188782 no 793 0.249165638182271 1210 3811116 SGTC_3225 9130819 49.47 µM 0.676937486165898 0.231914814664821 no 794 0.249222809365915 1230 4547121 SGTC_1420 4'-methoxyflavone 42 µM 0.676516457443984 0.232054203919802 no 795 0.249356400356093 1224 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_2404 5161160 200 µM 0.676262008588304 0.232138466470822 no 796 0.249437154568264 1197 2831543 SGTC_2684 capsaicin 100 µM 0.67572423096686 0.232316611380622 no 797 0.249607874304566 1235 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1736 st036774 51 µM 0.674785382750273 0.232627797668377 no 798 0.24990606426728 1258 1272247 SGTC_2759 disulfiram 3.38 µM 0.674490759476595 0.23272549988189 no 799 0.249999679274407 1196 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_3109 9122853 49.47 µM 0.67429879254724 0.232789171730434 no 800 0.250060685774857 1266 1234709 SGTC_2975 9084847 53.72 µM 0.673998373089711 0.232888834683508 no 801 0.250156174005328 1233 27211724 SGTC_2575 plumbagin 510 nM 0.673794659457484 0.23295642934975 no 802 0.250220935321508 1201 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1831 st055328 12 µM 0.672076109233632 0.233527098769964 no 803 0.250767622473703 1238 1103068 SGTC_1570 verbenone 133 µM 0.671346449771081 0.233769627004925 no 804 0.250999925198362 1249 29025 A natural terpanoid with antifungal properties. SGTC_220 paclitaxel 373.376 µM 0.671118524660014 0.233845414615518 no 805 0.251072513375151 1213 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_372 0155-0182 15.9 µM 0.671094805757027 0.233853302194184 no 806 0.251080067862317 1232 771486 SGTC_3081 9117243 49.47 µM 0.670671873755086 0.233993970438725 no 807 0.251214792186715 1258 45595589 SGTC_3316 9136639 10.545 µM 0.670359021621046 0.234098055995667 no 808 0.251314475335698 1247 4903665 SGTC_1559 coumarin 343 70.1 µM 0.670081663197152 0.234190354272463 no 809 0.25140286671363 1261 108770 A hepatotoxic, DNA x-linker. SGTC_2116 5511452 16.8835 µM 0.669365400829802 0.234428802499749 no 810 0.251631208412206 1235 870744 SGTC_322 k048-0136 19.3 µM 0.669262965790451 0.23446291474208 no 811 0.251663873261801 1238 6823282 SGTC_2673 kobusone 100 µM 0.669195819839748 0.234485276734478 no 812 0.251685286216432 1288 6710676 An epoxy ketone and protein crosslinker. SGTC_2544 sphondin 68.51 µM 0.668788592806822 0.234620923111151 no 813 0.251815172201448 1257 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_803 4488-1585 147 µM 0.668201767780151 0.23481646946432 no 814 0.252002403595001 1211 747204 SGTC_1876 myriocin 605 nM 0.667365374959019 0.235095334357158 no 815 0.252269388570696 1273 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_511 blebbistatin 171 µM 0.667231290447618 0.23514005698839 no 816 0.252312203558226 1292 3476986 A myosin inhibitor. SGTC_1191 1487-1166 10.6 µM 0.666853833715879 0.23526597936899 no 817 0.252432751136794 1297 3955771 SGTC_3066 9117245 49.47 µM 0.666671670448977 0.235326763710528 no 818 0.25249093910131 1287 17176980 SGTC_1305 1181-0477 144 µM 0.666617348099211 0.235344891700753 no 819 0.252508292523928 1247 6252086 SGTC_788 1182-0090 188 µM 0.666426643336328 0.235408538166871 no 820 0.252569218655263 1316 5715185 SGTC_3085 9117376 49.47 µM 0.664731740696901 0.235974618026011 no 821 0.253111044238769 1283 16480349 SGTC_3172 9105863 49.47 µM 0.664257677612342 0.236133084316639 no 822 0.253262701824615 1225 2348785 SGTC_2419 paclitaxel 166.5 µM 0.66351329513025 0.236382029218192 no 823 0.253500933702439 1194 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1824 st053723 68.6 µM 0.660549388067961 0.237374684396043 no 824 0.254450667890102 1229 675225 SGTC_2794 7785382 27.27 µM 0.660069852523809 0.237535502599017 no 825 0.254604502041507 1231 2205081 SGTC_2214 7179297 48.276 µM 0.659670320347715 0.237669536330891 no 826 0.254732708446019 1278 769744 SGTC_1686 st019653 115.5 µM 0.659351688297203 0.23777645969184 no 827 0.254834978926439 1270 97252 SGTC_1957 st077035 62.4 µM 0.658812711418298 0.237957384215473 no 828 0.255008021812585 1310 705593 SGTC_1652 st011932 78 µM 0.657482616472078 0.238404195147114 no 829 0.25543532246011 1223 1551076 SGTC_2781 5567276 71.43 µM 0.657363744820476 0.238444149349848 no 830 0.255473528866203 1256 2853274 SGTC_821 1114-0266 29.2 µM 0.656990403189732 0.238569657832525 no 831 0.255593543599267 1250 3123235 SGTC_3069 9117009 49.47 µM 0.656282758898356 0.238807650026582 no 832 0.255821104343251 1146 41904981 SGTC_936 3005-4620 401 µM 0.654228398877329 0.239499299641044 no 833 0.256482333910664 1293 777207 SGTC_1884 5633444 25 µM 0.652450385522924 0.240098792378129 no 834 0.257055334724808 1280 5724239 SGTC_2869 9037858 32.47 µM 0.651578754315067 0.240392978795256 no 835 0.257336478545718 1226 27187042 SGTC_453 enantio-paf c16 10 µM 0.65090021197693 0.240622131158047 no 836 0.257555452304666 1259 13871343 A lipid and platelet activating factor SGTC_1205 4161-2785 76 µM 0.650554968887824 0.240738769759982 no 837 0.257666903528466 1240 3498106 SGTC_1382 3002-2117 298 µM 0.649889657785471 0.240963628447138 no 838 0.257881749569224 1306 1497314 SGTC_331 k048-0133 24.5 µM 0.648935179435033 0.241286417897971 no 839 0.258190137393761 1239 6813582 SGTC_2563 tomatine 8.54 µM 0.648905431161824 0.241296482066912 no 840 0.258199752003336 1280 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_1790 st045711 43.5 µM 0.648881677798197 0.241304518255604 no 841 0.258207429197914 1285 585119 SGTC_2363 9053361 176 µM 0.648840849536711 0.241318331528118 no 842 0.258220625353215 1321 6469797 YMR079W SEC14 SGTC_2191 5911152 200 µM 0.6485457139186 0.241418196431759 no 843 0.258316026915161 1262 2875902 SGTC_2469 5655019 90.81 µM 0.648217548224365 0.241529264060873 no 844 0.258422126776701 1336 2788239 SGTC_1558 st069300 45.6 µM 0.647787037423961 0.241675012445542 no 845 0.258561350253405 1233 24208000 SGTC_564 3555-0129 330 µM 0.647431408098437 0.24179544588896 no 846 0.258676386996097 1192 563260 SGTC_2851 9015922 71.43 µM 0.647027564186814 0.241932246625614 no 847 0.258807052010336 1276 2996893 SGTC_117 lucigenin 22.078 µM 0.645124473363212 0.242577476853049 no 848 0.25942326265491 1243 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_3013 9080133 71.4286 µM 0.644365190480432 0.242835166468118 no 849 0.259669325732531 1345 17050193 SGTC_1476 4112-3294 3.34 µM 0.643532656400749 0.243117886656693 no 850 0.259939265945077 1316 704369 SGTC_486 niguldipine 82 µM 0.642467633604275 0.243479817002595 no 851 0.260284799006063 1275 1236 A calcium channel blocker. SGTC_2025 5147754 141 µM 0.640813694535557 0.244042457295403 no 852 0.26082186719355 1273 315777 YLR208W SEC13 SGTC_1808 st050063 61.5 µM 0.640274362557013 0.244226079838109 no 853 0.26099712260964 1293 4011993 SGTC_1240 0356-0016 42.1 µM 0.639502774783822 0.24448890632232 no 854 0.261247954560608 1279 4305613 SGTC_2524 avocatin b 10.57 µM 0.637569188856131 0.245148213905048 no 855 0.261877078844023 1224 6710748 SGTC_1529 apigenin 74 µM 0.637257826297954 0.24525447056302 no 856 0.261978458403693 1377 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_1409 3909-8004 61.9 µM 0.637034556855824 0.245330679501734 no 857 0.26205116725539 1286 2119279 SGTC_336 4111-0029 111 µM 0.633976765910591 0.2463756801961 no 858 0.263047992559091 1241 3131175 SGTC_2359 9039622 200 µM 0.633508288790458 0.246535992844056 no 859 0.263200884886297 1257 6463596 SGTC_1700 st030840 7.9285 µM 0.63273144185714 0.246801952616929 no 860 0.263454516887862 1317 5499307 SGTC_649 1123-0311 367 µM 0.632292883321513 0.246952164450607 no 861 0.263597756514356 1286 693629 YIL048W NEO1 SGTC_1803 st050068 52.4 µM 0.632065091876642 0.247030205196281 no 862 0.263672172205657 1371 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_2669 eugenol 100 µM 0.631102989244547 0.247359964510476 no 863 0.263986593369909 1280 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_1451 4152-0210 104 µM 0.629207382135694 0.24801036905819 no 864 0.264606648279376 1323 659563 SGTC_2337 9009472 200 µM 0.628805249790025 0.248148462505955 no 865 0.264738281344554 1358 5742383 SGTC_1181 1222-0449 220 µM 0.627595259493016 0.248564224015127 no 866 0.265134557475831 1362 658318 SGTC_2835 9006588 71.43 µM 0.626712493980991 0.248867782674207 no 867 0.265423856275123 1312 2345538 SGTC_571 k831-0106 44.2 µM 0.624375025835832 0.249672525474133 no 868 0.266190661222994 1314 4783639 SGTC_1266 0828-0227 32.9 µM 0.622634464823992 0.250272661816611 no 869 0.266762378767869 1304 3913820 SGTC_2634 4'-methoxyflavone 100 µM 0.621181978079557 0.250774056511665 no 870 0.267239947866002 1313 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_680 0417-1641 114 µM 0.620838630165716 0.250892657004785 no 871 0.267352901659051 1292 2835990 SGTC_1468 k284-1086 134 µM 0.620834348982502 0.250894136014143 no 872 0.267354310224701 1321 15996457 SGTC_2103 5378138 10 µM 0.620461803180411 0.251022856126267 no 873 0.267476897035056 1341 244142 SGTC_2316 5844804 197.44 µM 0.620391327001338 0.251047210623454 no 874 0.267500090525907 1352 776813 SGTC_2245 6637752 200 µM 0.619218334780603 0.251452745770772 no 875 0.267886267456549 1273 681890 SGTC_2415 st077333 57.7 µM 0.615223392352586 0.252836498681993 no 876 0.269203600704021 1406 2766255 SGTC_2081 5214970 32.255 µM 0.612736772199082 0.253699824455451 no 877 0.270025201999094 1301 2063512 SGTC_2324 6149169 200 µM 0.612590501267295 0.253750656197237 no 878 0.270073570253584 1253 2888231 SGTC_569 4130-2812 160 µM 0.612381257239214 0.253823381501885 no 879 0.270142769720484 1263 743552 SGTC_1563 conessine 56.1 µM 0.611749893238137 0.254042886031593 no 880 0.270351622976756 1387 441082 An anti-amoebic, histamine inhibitor. SGTC_21 0849-0113 22.993 µM 0.6093149461742 0.254890368918895 no 881 0.271157851064467 1298 1560156 SGTC_922 1866-0035 480 µM 0.608674923672314 0.255113373956655 no 882 0.271369965808907 1347 3156169 SGTC_365 0121-0052 13.6 µM 0.607713737172263 0.255448474775369 no 883 0.271688675213312 1337 3101739 SGTC_647 0140-0236 81 µM 0.607564477258311 0.25550053225042 no 884 0.2717381833978 1336 990837 SGTC_1372 2752-0194 270 µM 0.603233152501807 0.257013581781309 no 885 0.27317679797698 1301 823334 SGTC_2644 guaiazulene 100 µM 0.602940061147683 0.257116134668206 no 886 0.273274282057318 1347 3515 A coloring agent. SGTC_3110 9122132 49.47 µM 0.602778257839931 0.257172758883317 no 887 0.273328106265431 1414 918317 SGTC_3182 9108849 49.47 µM 0.602056047309248 0.257425580616539 no 888 0.273568415105625 1347 17133045 SGTC_182 3448-4371 550.524 µM 0.601519805195274 0.257613384534734 no 889 0.273746912297503 1382 3491403 SGTC_1218 1348-1416 30.7 µM 0.601165600162463 0.257737474024332 no 890 0.27386484697311 1331 6787668 SGTC_2086 5274770 176.623 µM 0.60093011774655 0.257819988305216 no 891 0.273943266145604 1345 689278 SGTC_2377 9073351 62.6 µM 0.600852281083007 0.257847265697172 no 892 0.27396918936124 1305 7337946 YHR072W ERG7 SGTC_515 4092-1064 102 µM 0.600286975204073 0.2580454186784 no 893 0.274157498785287 1414 717353 SGTC_780 0109-0199 192 µM 0.599875111213286 0.25818983639037 no 894 0.274294735325575 1421 610414 SGTC_3100 9120536 49.47 µM 0.599094803961845 0.258463561434586 no 895 0.274554833225309 1257 16421196 SGTC_1555 citronellol 128 µM 0.598587859068539 0.258641473843921 no 896 0.274723877100161 1334 8842 A terpine precursor. SGTC_3086 9117350 49.47 µM 0.598260244569393 0.258756483934938 no 897 0.274833149451363 1275 2679265 SGTC_1077 5-fluorocytosine 377 nM 0.596500324580541 0.259374762030555 no 898 0.275420518548446 1341 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2536 dehydroabietamide 32.04 µM 0.594042955071564 0.260239336448466 no 899 0.2762416916202 1429 3983547 SGTC_2876 9059903 25.97 µM 0.593173981015818 0.260545421966899 no 900 0.276532361796406 1336 6916095 SGTC_228 caffeine 993.056 µM 0.591895927728908 0.260995937198352 no 901 0.27696014045807 1361 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_1257 0669-0121 16 µM 0.591411064405028 0.261166956811564 no 902 0.277122514337772 1388 4307855 SGTC_53 0973-0023 39.979 µM 0.591305600258084 0.261204163449927 no 903 0.277157838958209 1340 674768 SGTC_2425 5628681 7.85 µM 0.590778194976468 0.261390267328859 no 904 0.277334523427999 1359 5714958 SGTC_83 0170-0301 39.027 µM 0.589529722148333 0.261831083336281 no 905 0.277752989963152 1321 3089716 SGTC_448 monastrol 171 µM 0.589440730646636 0.261862519379909 no 906 0.277782830146782 1334 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_2760 etidronate 98.04 µM 0.588989702963171 0.262021873634185 no 907 0.277934090552916 1331 3305 A chelator and antioxidant. SGTC_1568 digitonin 820 nM 0.586954005765449 0.262741731328328 no 908 0.278617298685154 1440 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_2736 butenafine 14.65 µM 0.586091585088521 0.26304700296443 no 909 0.278906985423805 1369 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_509 pifithrin 175 µM 0.585921247481404 0.263107318913342 no 910 0.278964219078718 1442 4817 A p53 inhibitor. SGTC_1392 3455-1037 33.9 µM 0.585536312481141 0.263243649071145 no 911 0.279093578772804 1383 981132 SGTC_1878 temozolomide 1 mM 0.584769717437656 0.263515256948902 no 912 0.279351284440957 1371 5394 DNA alkylating agent. SGTC_2074 5212007 75.395 µM 0.584055840526277 0.263768315111533 no 913 0.279591371801446 1312 758611 SGTC_253 dyclonine 31.25 µM 0.582489758952333 0.26432390027519 no 914 0.280118418831552 1422 3180 An oral anasthetic. SGTC_812 4251-0442 148 µM 0.581900215471445 0.26453320174886 no 915 0.280316947681993 1350 5723007 SGTC_2545 solidagenone 89.61 µM 0.581855126531222 0.264549212828609 no 916 0.280332134193657 1260 6708572 An anti ulcer agent SGTC_2001 4023502 57.655 µM 0.581563269403787 0.264652863199027 no 917 0.280430444912354 1398 108941 YCR052W RSC6 SGTC_2879 9041815 71.43 µM 0.58140454613182 0.26470924097678 no 918 0.280483917115773 1322 4942971 SGTC_1924 st058459 75.1 µM 0.581062481630818 0.264830761478091 no 919 0.280599171829775 1327 688683 SGTC_637 1181-0519 7.26 µM 0.580050761115295 0.265190347268712 no 920 0.28094019352052 1358 6252091 YGR060W ERG25 SGTC_187 1488-2104 32.728 µM 0.578341821088686 0.26579830145447 no 921 0.281516682258257 1410 2852859 SGTC_1090 efavirenz 20.7 µM 0.575792697080302 0.266706461421759 no 922 0.282377655157878 1395 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_3325 9138760 55.175 µM 0.575460329215405 0.266824987457864 no 923 0.282490006495533 1331 43844959 SGTC_3063 1327-0034 4 µM 0.574792948062622 0.267063063267959 no 924 0.282715668303886 1289 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_234 nsc-17383 10.7 µM 0.574531150025754 0.267156484128771 no 925 0.282804213807449 1409 408974 SGTC_2872 9044037 25.97 µM 0.573380452633753 0.267567298223588 no 926 0.283193561308693 1396 6465195 SGTC_3104 9120930 49.47 µM 0.572374761574136 0.267926603781072 no 927 0.283534055228178 1368 17014836 SGTC_2450 5739737 12.93 µM 0.572126836105118 0.268015218003578 no 928 0.283618024771159 1374 2262825 SGTC_934 2950-0684 338 µM 0.572031537473869 0.26804928383559 no 929 0.283650304505597 1458 1121253 SGTC_1147 3809-1045 12.3 µM 0.570601958799925 0.268560568241307 no 930 0.28413474521175 1325 325925 SGTC_1239 0337-0584 35.4 µM 0.57013320652596 0.268728322699198 no 931 0.284293677189747 1473 914301 YML130C ERO1 SGTC_2523 spermine 47.74 µM 0.568892182628085 0.269172707458873 no 932 0.284714655414961 1375 1103 A DNA binding polyamine. SGTC_3334 9142812 21.919 µM 0.568681651792036 0.269248130717689 no 933 0.284786100871923 1420 45283678 SGTC_2888 9058547 12.99 µM 0.567574251478875 0.269645034406743 no 934 0.285162047518024 1319 16476514 SGTC_2899 9053889 58.44 µM 0.567436112432801 0.269694565418787 no 935 0.285208960346138 1373 6470052 SGTC_1222 0366-0074 1.18 µM 0.565894379659459 0.270247676805525 no 936 0.285732791228889 1431 286520 SGTC_3125 9127534 49.47 µM 0.564308749972588 0.270817127687652 no 937 0.286272013785613 1306 1639235 SGTC_2207 7258803 200 µM 0.564024041798394 0.270919438987339 no 938 0.286368885183981 1382 3666799 SGTC_2343 7990716 14.84 µM 0.563689566655035 0.27103965892876 no 939 0.286482709569502 1424 6456862 SGTC_1889 st059080 5.18 µM 0.563185368668915 0.271220932394066 no 940 0.286654332462995 1431 176925 Isolated from Daphnopsis sellowiana. SGTC_2806 7952793 58.44 µM 0.562905328692386 0.271321640802715 no 941 0.286749675737861 1433 2972490 SGTC_2802 7925815 54.55 µM 0.561769949928296 0.271730138318273 no 942 0.28713638424855 1368 1262923 SGTC_376 3970-0862 59.1 µM 0.560392729221856 0.272226058586561 no 943 0.287605794932658 1429 3135186 SGTC_2178 5812956 200 µM 0.559520569905472 0.27254034489426 no 944 0.28790324840874 1392 5403383 SGTC_1320 1313-0481 95.3 µM 0.558939664831888 0.272749776405728 no 945 0.288101449009706 1404 6813365 YLR208W SEC13 SGTC_1888 azatryptophan 97.5 µM 0.558673728303071 0.272845680135317 no 946 0.288192206106307 1378 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_77 0828-0286 12.516 µM 0.554617668351276 0.274310472009079 no 947 0.289578100668157 1363 745345 SGTC_2206 7254556 146.969 µM 0.553841523820683 0.274591208158301 no 948 0.289843653810575 1402 4398905 SGTC_883 0850-0245 24.6 µM 0.553796130500163 0.274607631581503 no 949 0.289859188394963 1496 6823229 YPR165W RHO1 SGTC_2898 9056270 58.44 µM 0.549843266957308 0.276039643355499 no 950 0.2912134397388 1366 19154699 SGTC_3139 9095020 49.47 µM 0.549328392998285 0.276226437334442 no 951 0.291390052809381 1259 25236292 SGTC_506 n9-isopropylolomoucine 153 µM 0.549002660016577 0.27634464383558 no 952 0.291501812175953 1469 6610355 SGTC_3074 9116018 49.47 µM 0.548432179090607 0.276551727631708 no 953 0.291697593000009 1454 17027303 SGTC_1972 st070201 17.4 µM 0.546440199045494 0.277275409678478 no 954 0.292381691956945 1449 2829099 SGTC_596 1155-0152 116 µM 0.545061018412673 0.277777005067354 no 955 0.292855775901942 1400 280313 SGTC_2576 guaiol 23.12 µM 0.54308134792156 0.278497766681582 no 956 0.293536897138033 1452 227829 SGTC_2322 7413319 38.22 µM 0.542343930328417 0.278766479570893 no 957 0.293790798864972 1462 1840400 SGTC_2162 5663267 200 µM 0.54149746441852 0.279075084848087 no 958 0.294082372433618 1459 6456493 SGTC_301 4119-0100 24.5 µM 0.541075272467663 0.279229070024649 no 959 0.29422785060721 1425 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_82 0054-0107 293.755 µM 0.540871019742396 0.279303581507317 no 960 0.294298243589133 1452 3104697 SGTC_499 genistein 192 µM 0.536448087698677 0.280919434336791 no 961 0.295824452257049 1477 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_1512 0259-0544 12.2 µM 0.535564223896093 0.281242881781983 no 962 0.296129879968036 1444 18476 SGTC_555 4296-0685 37 µM 0.535486725766863 0.281271250574157 no 963 0.296156667096651 1450 2908540 YHR072W ERG7 SGTC_1376 2910-0861 41.3 µM 0.534777726363711 0.281530849427051 no 964 0.296401783419958 1476 1112859 SGTC_1872 amphotericin b 148 nM 0.533797312060701 0.281890016655426 no 965 0.296740886828933 1457 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_2429 5902844 64.44 µM 0.533748951295116 0.281907738961437 no 966 0.296757618333533 1495 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_3097 9117246 49.47 µM 0.533118200227858 0.282138933401049 no 967 0.296975880523115 1415 16423892 SGTC_737 1950-0117 57.9 µM 0.532712544094114 0.282287670134143 no 968 0.297116290690249 1431 5393513 SGTC_189 3970-0742 2.116 µM 0.532180527735203 0.282482794920934 no 969 0.297300484043774 1457 2891807 SGTC_1600 coumarin 106 71.1 µM 0.531074141436872 0.282888785852057 no 970 0.297683701276257 1471 100336 A hepatotoxic, DNA x-linker. SGTC_2793 7325131 81.82 µM 0.530416798701612 0.283130131866174 no 971 0.297911490700973 1479 4176441 SGTC_2767 sibutramine 71.45 µM 0.530302928913594 0.283171949652037 no 972 0.297950958150084 1521 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_214 4373-3496 70 µM 0.530060875494053 0.283260851713659 no 973 0.29803486216652 1492 3779166 SGTC_2037 5169046 200 µM 0.529181552490895 0.283583924543701 no 974 0.298339756242758 1462 5718022 SGTC_1524 corynanthine 62.1 µM 0.527520916291523 0.284194541429677 no 975 0.298915947662303 1502 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_2336 9001819 198.65 µM 0.52726681307215 0.28428803075796 no 976 0.299004158504297 1541 2989602 SGTC_2284 7945075 39.21 µM 0.52622185298464 0.284672645575205 no 977 0.299367036111667 1529 1245402 SGTC_1056 3448-1962 115 µM 0.526064430538231 0.284730609029227 no 978 0.299421720654923 1476 715507 SGTC_3102 9121669 49.47 µM 0.524011281094475 0.285487100652438 no 979 0.300135346766397 1490 41905072 SGTC_161 4065-0411 162.148 µM 0.523726948306031 0.285591939660471 no 980 0.300234234715524 1503 1906281 YLR208W SEC13 SGTC_1785 bathophenanthroline 24 µM 0.522638128307547 0.285993578023928 no 981 0.300613050967921 1406 72812 An iron chelator. SGTC_155 k072-0202 43.6 µM 0.522357363242872 0.286097188727958 no 982 0.300710768185062 1400 5857737 SGTC_1138 3761-0006 1.03 µM 0.521941643818094 0.28625063437012 no 983 0.300855481114432 1469 12061087 SGTC_2986 9022445 71.43 µM 0.521378301562294 0.286458631217945 no 984 0.301051632012562 1536 6459286 SGTC_368 fentichlor 4.58 µM 0.520388066160478 0.286824418996624 no 985 0.301396563043212 1406 7329 A pesticide. SGTC_603 3794-0023 45.9 µM 0.519973074136302 0.286977780678869 no 986 0.301541171074555 1524 3802260 SGTC_1848 st056003 16.4 µM 0.519883904638277 0.287010738632446 no 987 0.301572247132454 1480 146492 SGTC_2106 5357045 167.29 µM 0.518606345964783 0.287483134043886 no 988 0.302017641414276 1517 668842 SGTC_1963 st076565 50.3 µM 0.516552652992166 0.288243285752442 no 989 0.302734237233394 1463 4914280 SGTC_537 1334-0398 209 µM 0.515593769264581 0.288598530304032 no 990 0.303069081478326 1548 5846986 SGTC_1553 gossypol 38.6 µM 0.515038798088765 0.28880422865342 no 991 0.303262954263645 1414 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2873 9040596 71.43 µM 0.514360703354158 0.289055656013575 no 992 0.303499914071763 1441 6463863 SGTC_1000 4048-0884 8.67 µM 0.513822353232661 0.289255341452067 no 993 0.303688099075262 1492 13040088 SGTC_3162 9099653 49.47 µM 0.513194756255978 0.289488212255654 no 994 0.303907546820262 1462 25237511 SGTC_2847 9005661 71.43 µM 0.511302028760352 0.290191044299266 no 995 0.304569792322187 1407 2991449 SGTC_2610 ononetin 44.17 µM 0.510309942818817 0.290559757541207 no 996 0.304917169027458 1438 259632 SGTC_2496 diffractaic acid 79.83 µM 0.510308509982452 0.290560290219838 no 997 0.304917670859228 1590 94870 An apoptosis inducer which activates caspases. SGTC_3235 9132602 49.47 µM 0.50893959666351 0.291069413121296 no 998 0.305397281964111 1494 4912240 SGTC_1655 st012546 55.1 µM 0.506724418653145 0.29189415827369 no 999 0.306174097320969 1454 720985 YLR208W SEC13 SGTC_36 0335-0881 14.2 µM 0.504996281522527 0.292538325358186 no 1000 0.306780723851967 1489 23828853 SGTC_25 0118-0223 35.662 µM 0.504713969579187 0.292643620527318 no 1001 0.306879873941409 1527 5333628 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.504398380000067 0.29276134824441 no 1002 0.306990728112778 1569 23847180 SGTC_3258 9138477 49.47 µM 0.503524062110842 0.293087619095734 no 1003 0.307297933646351 1518 4970355 SGTC_3279 9140807 49.47 µM 0.502387949422227 0.293511836184196 no 1004 0.307697327026692 1473 45595718 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.501308542591808 0.293915142907864 no 1005 0.308076997058294 1452 4330530 SGTC_183 3914-0051 30.55 µM 0.499801425827836 0.294478686379034 no 1006 0.308607453277086 1595 1596232 SGTC_1938 st074717 56.4 µM 0.497121957772857 0.295481826839837 no 1007 0.309551525603084 1411 17250979 SGTC_1750 st081859 2.357 µM 0.494990074766101 0.29628108304732 no 1008 0.310303563296776 1519 5291695 SGTC_2181 6316240 54.2555 µM 0.493831855722918 0.296715721802745 no 1009 0.310712466769425 1443 12779990 SGTC_3029 9088683 49.47 µM 0.491224839067949 0.297695109757716 no 1010 0.311633716331625 1485 25236615 SGTC_3049 9092223 49.47 µM 0.488394617169473 0.298760016757627 no 1011 0.312635176943449 1495 8623917 SGTC_2156 5649887 115 µM 0.486499901604314 0.299473893708821 no 1012 0.313306387542432 1590 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_710 3448-4187 58 µM 0.486173430835598 0.299596977016793 no 1013 0.313422103691606 1520 3946412 SGTC_1162 k048-0130 20.1 µM 0.486032134246009 0.29965025459436 no 1014 0.313472191351187 1481 6797406 SGTC_919 tnp00227 403.569 nM 0.484994566772586 0.300041613297672 no 1015 0.313840099793948 1527 1269246 A methoxyflavone. YNL221C POP1 SGTC_1445 4239-0156 97.7 µM 0.484444438686265 0.300249209144042 no 1016 0.314035243471325 1653 4008346 SGTC_3036 9090181 49.47 µM 0.484215453357349 0.300335637978458 no 1017 0.314116485414263 1521 25236586 SGTC_26 0302-0163 425.158 µM 0.484164608373814 0.300354830570216 no 1018 0.314134525981169 1515 3100915 SGTC_387 norethindrone acetate 66.7 µM 0.484048887215919 0.300398514210807 no 1019 0.314175587248679 1487 541197 SGTC_3039 9090270 49.47 µM 0.483462972624281 0.300619735463795 no 1020 0.314383522260325 1558 17173750 SGTC_1815 st051655 58.2 µM 0.482941107311833 0.30081683580859 no 1021 0.31456877645085 1521 5984156 SGTC_2932 9016711 44.54 µM 0.482159699505397 0.301112070225966 no 1022 0.314846251543864 1621 7117328 SGTC_552 k242-0005 476 µM 0.480731896543824 0.301651865046226 no 1023 0.315353529213029 1509 4088318 SGTC_751 0833-0568 350 µM 0.479830486029529 0.30199287601399 no 1024 0.315673966698433 1547 6954252 SGTC_408 cantharidin 100 µM 0.479682558356675 0.302048854797697 no 1025 0.315726565943283 1519 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2999 9069765 71.4286 µM 0.478598484578879 0.302459232069713 no 1026 0.316112148316775 1573 2097066 SGTC_844 0330-0132 15.3 µM 0.47750005954868 0.302875296817057 no 1027 0.316503039226118 1562 2828079 SGTC_2703 st077852 53.4 µM 0.47748256964448 0.302881923767759 no 1028 0.3165092649287 1536 6281836 SGTC_1211 1056-0033 32.3 µM 0.477263937439302 0.302964769312124 no 1029 0.316587093588656 1532 6741922 SGTC_1125 tnp00248 1.32998 µM 0.477098714422911 0.303027383424596 no 1030 0.316645915041508 1667 24207736 SGTC_1345 1488-0192 31.4 µM 0.475513242042338 0.303628519649497 no 1031 0.317210598524561 1572 658348 SGTC_226 1,3-diallylurea 8.28947 mM 0.474705176187666 0.303935104718892 no 1032 0.317498564008045 1522 74537 YKL182W FAS1 SGTC_1097 itavastatin 7.23 µM 0.473733877089627 0.304303804038868 no 1033 0.317844846124533 1526 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_968 1309-0633 340 µM 0.472147921520153 0.304906250953954 no 1034 0.318410604577695 1544 3761976 SGTC_1007 4101-0031 70 µM 0.4718227001762 0.305029856175225 no 1035 0.318526673294895 1621 1146276 SGTC_85 0868-0259 160.055 µM 0.46959416375007 0.305877442612541 no 1036 0.319322497592309 1554 83173 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.469547659306099 0.305895140898087 no 1037 0.31933911350652 1531 17037758 SGTC_2096 5468907 200 µM 0.465688172625857 0.307365529718601 no 1038 0.320719359741551 1640 759785 SGTC_1176 0848-0131 83.3 µM 0.463291728977777 0.308280090406798 no 1039 0.321577636771412 1634 6769040 SGTC_1188 1403-0014 4.57 µM 0.462663224190465 0.308520145663894 no 1040 0.321802891305855 1531 9614867 SGTC_333 3486-0131 40.1 µM 0.461634996671154 0.308913050164107 no 1041 0.322171546685011 1649 6744690 SGTC_463 ikarugamyin 104 µM 0.461382253400116 0.309009661492324 no 1042 0.322262190761822 1579 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_760 0568-0725 82.9 µM 0.46137848152959 0.309011103393089 no 1043 0.322263543588967 1638 3916171 SGTC_1895 st058434 18.3 µM 0.460814483842738 0.309226740056323 no 1044 0.322465854691329 1639 5393175 SGTC_2852 9023854 51.95 µM 0.457638471965267 0.310442269573536 no 1045 0.323606099449223 1591 19798528 SGTC_671 0560-0003 407 µM 0.454508332471122 0.31164227170309 no 1046 0.3247314979994 1580 3238678 SGTC_1221 2958-7315 257 µM 0.454029068051773 0.311826184532187 no 1047 0.32490395258018 1553 4562705 SGTC_2104 5389443 200 µM 0.452803892436947 0.312296546436213 no 1048 0.325344980258707 1617 2244536 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.452087724221078 0.31257163514154 no 1049 0.325602893414497 1505 4174840 SGTC_3224 9130643 49.47 µM 0.451748542578356 0.312701955293905 no 1050 0.325725071811413 1609 17644395 SGTC_2526 patulin 37.61 µM 0.45168205301425 0.312727504617094 no 1051 0.325749024560845 1603 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_2252 omeprazole 400 µM 0.451543270767634 0.312780836072554 no 1052 0.325799022940682 1614 4594 A proton pump inhibitor. SGTC_2478 5763493 32.33 µM 0.451366458189315 0.312848787559703 no 1053 0.325862726855031 1606 1365576 YLR208W SEC13 SGTC_955 1216-0110 33 µM 0.450477332635066 0.313190587005337 no 1054 0.326183147490704 1479 3619719 SGTC_2071 5230951 39.92 µM 0.44920929999263 0.313678324420551 no 1055 0.326640339651954 1552 1799272 SGTC_1238 0333-0287 48.8 µM 0.448648278080227 0.313894220512291 no 1056 0.326842700583296 1534 7226 SGTC_573 3702-0553 84.7 µM 0.444631735066053 0.315441750418964 no 1057 0.328292954805761 1547 1222756 SGTC_3145 9085516 49.47 µM 0.444281138227703 0.315576985799266 no 1058 0.328419668181925 1532 25236195 SGTC_1026 k007-1105 30.6 µM 0.44253859250087 0.316249502485661 no 1059 0.329049754986652 1554 7066794 SGTC_3096 9117468 49.47 µM 0.442414713125262 0.316297335575614 no 1060 0.32909456703264 1515 41316311 SGTC_2093 5331342 194.4 µM 0.442192711427654 0.316383063968818 no 1061 0.329174879928729 1631 33839 SGTC_851 0394-0702 453 µM 0.441621383284529 0.316603733973608 no 1062 0.329381603865144 1658 762646 SGTC_1030 k029-0042 36.7 µM 0.441187035983182 0.316771540136662 no 1063 0.329538798864681 1589 6080581 SGTC_2927 9011802 47.9 µM 0.440190792361363 0.317156572265809 no 1064 0.329899463991698 1488 43912568 SGTC_171 k064-0041 9.68 µM 0.438446903126769 0.317831033909954 no 1065 0.330531176203726 1509 53325 SGTC_1619 st003326 88.7 µM 0.437585137715159 0.318164551295947 no 1066 0.330843523442594 1653 2849032 SGTC_2476 5806916 10.51 µM 0.437057006665882 0.318369019606215 no 1067 0.331035002999334 1606 2870194 SGTC_862 0452-0056 10.2 µM 0.436074254763273 0.318749643695705 no 1068 0.331391427828438 1548 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_2229 7354935 190 µM 0.435554493330385 0.318951026925505 no 1069 0.331579996886726 1590 318112 SGTC_758 0868-0029 16 µM 0.433281094198305 0.319832490330086 no 1070 0.332405285605942 1705 762687 SGTC_208 k072-0098 12.366 µM 0.433017890391883 0.31993460802164 no 1071 0.332500886376911 1580 5948901 SGTC_1014 4130-3005 69.3 µM 0.431232045875048 0.32062783923875 no 1072 0.333149827547066 1551 743608 SGTC_33 0986-0033 35.816 µM 0.431001937531473 0.32071720855013 no 1073 0.333233480839957 1581 2848082 SGTC_274 sirtinol 40.1 µM 0.429789942298452 0.321188093795691 no 1074 0.333674224888362 1532 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_1942 st076330 65.2 µM 0.429508288751622 0.32129756324684 no 1075 0.333776681564885 1608 24208414 SGTC_886 0866-0150 153 µM 0.428397162281128 0.321729572861621 no 1076 0.33418099516811 1716 271463 SGTC_2583 asiatic acid 100 µM 0.427346097620222 0.322138452211497 no 1077 0.334563630827531 1598 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_3267 9137951 49.47 µM 0.427220154548059 0.32218746034527 no 1078 0.334609491412274 1614 16643986 SGTC_3336 9143619 71.43 µM 0.425888054733565 0.322706008492543 no 1079 0.335094709758638 1630 45595730 SGTC_2054 5233173 129 µM 0.425857607919682 0.32271786459772 no 1080 0.335105803254595 1616 6889 SGTC_1413 3910-0535 34.4 µM 0.422361808537536 0.32408033788758 no 1081 0.336380474881688 1675 2876951 SGTC_469 w7 172 µM 0.422220714008293 0.324135378555145 no 1082 0.336431961740034 1627 45115570 A P450 inhibitor. SGTC_1636 st007707 68.9 µM 0.422106784473256 0.32417982502307 no 1083 0.336473538048389 1701 403051 SGTC_2694 st077685 81.9 µM 0.422036039745562 0.32420742538983 no 1084 0.336499355930107 1539 2838096 SGTC_2341 7987486 176.74 µM 0.421535913703484 0.324402572244349 no 1085 0.336681896035408 1748 1258686 SGTC_319 1348-1596 45.5 µM 0.42090623481953 0.324648338606692 no 1086 0.336911776128348 1715 5380505 SGTC_1753 st043925 64 µM 0.420598668942804 0.324768410652385 no 1087 0.337024082932416 1661 670181 SGTC_2564 betulinic acid 100 µM 0.420465318682423 0.324820475528809 no 1088 0.337072779916052 1802 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_464 bw-b 70c 158 µM 0.420237622190484 0.324909384575825 no 1089 0.337155936663655 1672 5353454 SGTC_3105 9121040 49.47 µM 0.420168266900335 0.324936467838999 no 1090 0.337181267402569 1544 41448907 SGTC_2808 7946468 45.46 µM 0.420120701900308 0.324955042521716 no 1091 0.337198640067154 1633 2970879 SGTC_2503 beta-caryophyllene alcohol 24.72 µM 0.417977746026648 0.325792342400786 no 1092 0.33798169401094 1560 61125 An anti-inflammatory. SGTC_3337 9144342 33.5465 µM 0.417714775832767 0.325895151292958 no 1093 0.338077833909759 1666 17682949 SGTC_2309 7664088 163.95 µM 0.417096566560279 0.326136893976717 no 1094 0.338303888096581 1730 704922 SGTC_484 loperamide 105 µM 0.41574617097894 0.326665202636211 no 1095 0.338797875924739 1606 3955 An opioid-receptor agonist. SGTC_2820 7989630 71.43 µM 0.414408105473704 0.327189030520588 no 1096 0.339287626918908 1689 2984098 SGTC_2150 5556613 200 µM 0.414081152741414 0.327317078279354 no 1097 0.339407337591242 1624 743190 SGTC_2843 9000894 45.46 µM 0.411615766267404 0.328283275657542 no 1098 0.34031053684826 1554 2242070 SGTC_353 1988-1175 58.3 µM 0.411054701530799 0.328503320591069 no 1099 0.340516212292395 1541 2788357 SGTC_1793 st048256 72.231 µM 0.411028568761447 0.328513571096927 no 1100 0.34052579321518 1587 672022 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.410145619547594 0.328859981266963 no 1101 0.340849564787143 1570 16623 A steroid. SGTC_1331 1472-0049 76.2 µM 0.409693549607808 0.329037400197341 no 1102 0.341015381216416 1576 24051409 SGTC_2791 5663188 71.43 µM 0.408931906676845 0.329336400948009 no 1103 0.34129481653382 1697 54690634 SGTC_3201 9113999 49.47 µM 0.408129608796192 0.32965147982353 no 1104 0.341589261677267 1695 16649224 SGTC_425 3825-7017 13.1 µM 0.408100427290514 0.329662942281733 no 1105 0.34159997317452 1672 3397440 SGTC_2656 pseudo-anisatin 100 µM 0.407425006789174 0.329928291284498 no 1106 0.341847931749564 1644 6708809 A neurotoxin. SGTC_1019 4262-0212 3.4 µM 0.405903589331471 0.330526316200525 no 1107 0.34240672032251 1650 4677213 SGTC_1854 st056233 32.9 µM 0.404302208467785 0.331156240147428 no 1108 0.342995250835412 1733 5393174 SGTC_2299 7976368 114.88 µM 0.402603925490775 0.331824804254187 no 1109 0.343619810699169 1729 2979718 SGTC_933 2914-0560 114 µM 0.401966639589826 0.332075823391623 no 1110 0.343854289013477 1778 463887 SGTC_2253 7938677 135.83 µM 0.401690101012108 0.332184772018965 no 1111 0.34395605529 1738 2301972 SGTC_1216 1165-0504 9.65 µM 0.401328268653477 0.332327345482533 no 1112 0.344089226774695 1719 6304004 SGTC_2287 7945887 168.79 µM 0.401015000413336 0.332450802739372 no 1113 0.344204539979226 1721 1245853 SGTC_1160 4092-0570 10.5 µM 0.399933629600962 0.332877104524211 no 1114 0.344602700950275 1568 4994975 SGTC_2231 micatex 6.853 µM 0.395620754368461 0.334579486606072 no 1115 0.346192411978031 1662 20737 An antifungal of unknown mechanism. SGTC_1781 st038725 66.3 µM 0.393907502755717 0.335256690260551 no 1116 0.346824665449855 1630 4270275 YIL048W NEO1 SGTC_3341 9147222 25.867 µM 0.393841468325772 0.335282802683942 no 1117 0.346849043159687 1650 1939759 SGTC_2439 5492030 7.2 µM 0.393812050654526 0.335294435760956 no 1118 0.346859903387213 1727 5722370 SGTC_1941 st076221 61.8 µM 0.392412083490941 0.335848228498354 no 1119 0.347376879624036 1762 2828568 SGTC_2367 9070478 135.38 µM 0.391652413004741 0.336148884888809 no 1120 0.347657527724517 1628 572802 SGTC_859 0439-0102 54.6 µM 0.391056654733452 0.336384742761238 no 1121 0.347877679515707 1750 610143 SGTC_217 ketoconazole 989 nM 0.391037145499152 0.336392467464014 no 1122 0.347884889671327 1613 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_1058 3448-5425 97.3 µM 0.390791552504159 0.336489716186414 no 1123 0.347975659788407 1633 7279705 SGTC_1430 4049-0248 69.1 µM 0.390508420657867 0.336601842935064 no 1124 0.348080314914936 1731 22774488 SGTC_1148 3909-7663 27.7 µM 0.390346360828952 0.33666602890815 no 1125 0.348140222928197 1716 4084526 SGTC_2957 9076800 11.52 µM 0.390344176537297 0.336666894058718 no 1126 0.348141030412505 1588 16459615 SGTC_2681 menadione 3.18 µM 0.386673052026299 0.338122165375361 no 1127 0.349499134317854 1651 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_942 3253-1115 227 µM 0.386576279300242 0.338160559933075 no 1128 0.349534960800168 1748 46497897 SGTC_563 tetrahydrosecaminediol 614 µM 0.386503898257695 0.338189278196057 no 1129 0.349561758050115 1748 334274 A psychoactive constituent of the cannabis plant. SGTC_2855 9016525 58.44 µM 0.385086560557841 0.338751817700006 no 1130 0.350086642397497 1615 43811474 SGTC_2698 st077697 67.5 µM 0.384582507834697 0.338951962389224 no 1131 0.350273377961612 1584 3154499 SGTC_3176 9106582 49.47 µM 0.383567704308607 0.33935504925328 no 1132 0.350649440287144 1667 17018027 SGTC_1780 st038448 24.544 µM 0.381694296328641 0.340099662457521 no 1133 0.351344065613305 1753 728868 YDL195W SEC31 SGTC_348 k064-0012 10.7 µM 0.381152126951871 0.34031527211968 no 1134 0.351545184876038 1609 5066323 SGTC_1089 terbinafine 2.25 µM 0.379758074202141 0.340869897946578 no 1135 0.352062503400837 1740 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_3246 9135460 32.98 µM 0.378069689337099 0.341542084939379 no 1136 0.35268941224751 1711 41446951 SGTC_416 estradiol valerate 100 µM 0.374897150186223 0.342806508710988 no 1137 0.353868479291909 1683 13791 A steroid. SGTC_2456 5770359 74.46 µM 0.374743935327 0.34286761762879 no 1138 0.353925456851061 1746 3118787 SGTC_3216 9129716 49.47 µM 0.372676172355792 0.343692735267757 no 1139 0.354694736320675 1590 8056934 SGTC_2014 4013930 200 µM 0.372559630088322 0.343739262373427 no 1140 0.354738111762928 1717 64556 SGTC_2546 rhodinyl acetate 100 µM 0.371175031190727 0.344292215969898 no 1141 0.355253584550793 1793 6708682 SGTC_3207 9114163 49.47 µM 0.369917351690383 0.344794771703185 no 1142 0.355722036159053 1840 849233 SGTC_3034 9090421 49.47 µM 0.369742552440447 0.344864641383025 no 1143 0.355787161422232 1770 17173761 SGTC_3151 9099821 49.47 µM 0.36960424141973 0.344919929962127 no 1144 0.355838695184888 1628 17174189 SGTC_2305 7443522 69.23 µM 0.368849974499371 0.345221499582123 no 1145 0.356119776338026 1755 5415886 SGTC_2430 5571206 200 µM 0.367161601172864 0.345896897994364 no 1146 0.356749239951696 1819 1731771 SGTC_1735 st034310 56.75 µM 0.366387435983469 0.346206750771544 no 1147 0.357037996790364 1764 871153 SGTC_718 1130-0073 349 µM 0.36559713579463 0.346523167662341 no 1148 0.357332856336081 1746 6740020 SGTC_139 0099-0334 718.624 µM 0.365397682728171 0.346603040735026 no 1149 0.357407285379938 1732 97690 SGTC_1618 st003135 44.5 µM 0.364644249245912 0.346904822589499 no 1150 0.357688489842439 1753 1270615 SGTC_2905 7799065 20.05 µM 0.364641022336715 0.346906115311642 no 1151 0.357689694390104 1785 1296806 SGTC_3017 9080681 49.47 µM 0.363992913963932 0.34716578811105 no 1152 0.357931650404101 1661 16451914 SGTC_2913 7966556 36.57 µM 0.362789097740328 0.347648302664055 no 1153 0.358381218294931 1777 2976516 SGTC_1350 1495-0454 146 µM 0.362647589581057 0.347705038307059 no 1154 0.358434077747124 1766 1069057 SGTC_2771 fluoxetine 41.05 µM 0.361929943776279 0.347992820467207 no 1155 0.358702191411699 1745 3386 A selective serotonin reuptake inhibitor. SGTC_1491 4138-0063 26.5 µM 0.361549993304046 0.348145219352725 no 1156 0.358844169745508 1780 23883227 SGTC_1798 st045719 60.953 µM 0.361120535691617 0.348317505177768 no 1157 0.359004671186308 1767 3980186 SGTC_1113 artemisinin 1.17947 µM 0.360143103223172 0.3487097391257 no 1158 0.359370060347646 1826 2240 An anti-malaria and mitochondrial poison. SGTC_222 nsc-310342 10.666 µM 0.359583887578294 0.348934219593488 no 1159 0.359579167279245 1793 432556 SGTC_3087 9117406 49.47 µM 0.357551907337491 0.349750342235888 no 1160 0.360339337157991 1678 42546093 SGTC_2973 9094665 17.96 µM 0.356990223387565 0.349976059181919 no 1161 0.360549562386624 1808 25237061 YIL048W NEO1 SGTC_2101 5377231 179.231 µM 0.355984816481754 0.350380221908942 no 1162 0.360925968019996 1775 2844213 SGTC_3108 9121785 49.47 µM 0.355849810110309 0.350434505929291 no 1163 0.360976522161572 1804 17140271 SGTC_1763 st044482 94.5 µM 0.355369801393579 0.350627534908455 no 1164 0.361156284665134 1754 88505 SGTC_2295 7971645 200 µM 0.354207525681999 0.351095087973877 no 1165 0.361591682032486 1757 2978226 YKL099C UTP11 SGTC_2605 digitonin 300 nM 0.353124191819816 0.351531087880075 no 1166 0.361997668622288 1819 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.352373599132041 0.351833286986116 no 1167 0.362279049362453 1774 688761 SGTC_2919 7978188 46.38 µM 0.351894830794559 0.352026094731801 no 1168 0.362458568002776 1831 2980291 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.351514334293837 0.352179353960765 no 1169 0.36260126027736 1659 2333 A French combination drug. SGTC_3027 9089541 49.47 µM 0.350078258696916 0.35275800338587 no 1170 0.363139983406 1694 9943819 SGTC_887 0885-0007 9.62 µM 0.350032300302618 0.352776527404024 no 1171 0.363157228516134 1762 5719458 SGTC_577 r071-0003 38.6 µM 0.349322828567336 0.353062531769229 no 1172 0.363423480963014 1658 4568517 YMR134W ERG29 SGTC_209 4077-0173 175.592 µM 0.349208567937995 0.353108600622322 no 1173 0.363466367170207 1714 15993494 SGTC_802 4112-3352 742 µM 0.348965725980787 0.353206519454623 no 1174 0.363557520350971 1809 704594 SGTC_1647 st011722 22.4 µM 0.348611873047156 0.353349217575954 no 1175 0.363690356450509 1723 2854783 SGTC_3132 9126706 49.47 µM 0.348437064024161 0.353419720346122 no 1176 0.363755985661999 1740 850858 SGTC_1900 st060200 72.8 µM 0.348388709539949 0.353439223231569 no 1177 0.363774140274475 1675 688945 SGTC_2408 sulbentine 18.36 µM 0.347918226614596 0.353629003884255 no 1178 0.363950798282935 1760 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_1466 k213-0079 57.5 µM 0.347597079592713 0.35375856719179 no 1179 0.36407139991303 1710 3657981 SGTC_1378 2093-0007 380 nM 0.346852872875089 0.354058874470027 no 1180 0.364350926579819 1697 3618014 SGTC_48 0382-0018 55 µM 0.346325998737258 0.354271537160031 no 1181 0.364548866001046 1825 762596 SGTC_1448 4255-0083 152 µM 0.345172290287496 0.354737368209836 no 1182 0.364982424596103 1834 5399660 SGTC_2650 prasterone 100 µM 0.344702158430452 0.354927254967629 no 1183 0.365159147645867 1743 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_201 4262-0159 12.803 µM 0.344594027615425 0.354970934218865 no 1184 0.365199798183294 1825 1341029 SGTC_2721 ifenprodil 61.44 µM 0.343554807318858 0.35539082253539 no 1185 0.365590558284924 1792 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_170 4197-0004 226 µM 0.342750495981628 0.355715918416393 no 1186 0.365893085427639 1782 218692 SGTC_1004 4084-0029 199 µM 0.340531344182141 0.356613424654129 no 1187 0.366728211214097 1839 716894 YLR208W SEC13 SGTC_2251 lansoprazole 556 µM 0.340141658285461 0.356771110047317 no 1188 0.366874925639892 1647 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_185 k048-0037 25.491 µM 0.339781695500668 0.356916789809913 no 1189 0.367010466770566 1844 6827589 SGTC_1062 mesoridazine 14.2 µM 0.338428566787373 0.357464598116331 no 1190 0.367520124820095 1718 4078 A neuroleptic. SGTC_786 4544-0069 423 µM 0.338228354455177 0.357545678194008 no 1191 0.367595554954525 1785 748821 YLR208W SEC13 SGTC_932 2857-0803 154 µM 0.337920767338905 0.357670254412211 no 1192 0.367711448564052 1826 674898 SGTC_1607 st000305 50.6 µM 0.337592073081249 0.35780339601903 no 1193 0.367835308301253 1788 5457690 SGTC_264 promethazine 12.5 mM 0.337167415399057 0.357975434392723 no 1194 0.367995349664951 1788 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_1725 st036284 20.55 µM 0.3363727442346 0.358297451024487 no 1195 0.368294900099622 1868 707914 SGTC_2320 7373003 200 µM 0.334810938623883 0.358930619433472 no 1196 0.368883854232814 1650 5415828 SGTC_491 tetrandrine 80.3 µM 0.331343411460333 0.360337766578586 no 1197 0.370192551939937 1828 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1112 tnp00069 1.16933 µM 0.329829370927633 0.360952770148172 no 1198 0.370764446652944 1828 145826 SGTC_130 0136-0219 337.655 µM 0.32968871527477 0.36100992278582 no 1199 0.370817590677792 1866 234244 SGTC_1623 st003709 20.3 µM 0.328500708677161 0.361492769411691 no 1200 0.371266554272256 1682 16192618 SGTC_2608 thymoquinone 42.66 µM 0.328143423441251 0.361638025582124 no 1201 0.371401611448353 1743 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.326533189112328 0.362292921899998 no 1202 0.372010491433924 1723 6708784 An antioxidant flavonoid SGTC_1271 0832-2808 169 µM 0.326465370889076 0.362320513024354 no 1203 0.372036142663703 1869 3663794 SGTC_1325 1431-0015 227 µM 0.326296701176861 0.362389137607876 no 1204 0.372099941925038 1665 1103340 SGTC_1299 1079-1439 3.74 µM 0.326206540440333 0.362425822018199 no 1205 0.372134046633242 1693 323161 SGTC_1650 st011916 45.8 µM 0.324186942893509 0.363247882106243 no 1206 0.372898253400806 1848 242528 SGTC_141 0443-0274 32.331 µM 0.323667482224363 0.363459426236955 no 1207 0.3730948960535 1881 1627241 SGTC_424 splitomicin 100 mM 0.323656158717425 0.363464038063436 no 1208 0.373099182953259 1661 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2308 7584454 197.62 µM 0.323479186941394 0.363536117520797 no 1209 0.373166183696239 1836 893577 SGTC_1909 st060837 51.5 µM 0.32346031566299 0.363543803955269 no 1210 0.373173328506331 1703 678937 SGTC_937 3122-0005 46.7 µM 0.322783481941067 0.363819520462364 no 1211 0.373429611736703 1871 759535 SGTC_542 3381-0244 89.3 µM 0.322653318457629 0.363872552241948 no 1212 0.373478904590076 1861 1112843 SGTC_1046 2001-0062 216 µM 0.32189510164183 0.36418152008084 no 1213 0.373766082090658 1704 739778 SGTC_460 trequinsin 123 µM 0.319125977191597 0.365310666869366 no 1214 0.37481549289134 1779 5537 A vasodilator. SGTC_1993 st073995 70.8 µM 0.318942620543496 0.36538547430052 no 1215 0.374885012105461 1778 3098394 SGTC_2942 9052777 62.25 µM 0.318248396273537 0.365668756306041 no 1216 0.375148262319382 1759 6469503 SGTC_1877 wortmannin 25 µM 0.317788204032063 0.365856580660003 no 1217 0.375322799529547 1856 312145 A covalent inhibitor of PI 3-kinase. SGTC_2318 6029776 164 µM 0.31770536715477 0.365890393388287 no 1218 0.375354219801771 1816 818325 SGTC_1708 st033234 31.827 µM 0.316529603873209 0.366370433935218 no 1219 0.375800279360201 1831 674664 SGTC_1728 st035614 33.7865 µM 0.315846679851426 0.36664935418516 no 1220 0.376059442459431 1772 15945546 SGTC_1696 st025591 34.7925 µM 0.315585068027277 0.366756220514372 no 1221 0.37615873644745 1749 2787147 SGTC_1959 st077091 55.8 µM 0.315399613630987 0.366831983402546 no 1222 0.376229130076785 1737 821356 YKL052C ASK1 SGTC_465 cgp-37157 41 µM 0.314704804187808 0.36711587702547 no 1223 0.376492898129036 1845 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_84 0443-0269 128.823 µM 0.314100880789366 0.36736269437393 no 1224 0.376722210295025 1823 6150058 SGTC_982 1491-0518 27.5 µM 0.313949445023758 0.367424593229562 no 1225 0.37677971789486 1759 3091256 SGTC_3251 9135047 49.47 µM 0.312480340970489 0.368025263121776 no 1226 0.377337750619785 1866 17682963 SGTC_109 0132-0036 33.701 µM 0.31139809839247 0.368467964269363 no 1227 0.377748999678293 1842 67274 A color developer. SGTC_1460 k062-0059 9.15 µM 0.311069259899096 0.368602513263469 no 1228 0.377873984835742 1696 1373085 SGTC_2956 9076196 2.52 µM 0.310383405101414 0.368883192433279 no 1229 0.378134706120532 1828 16423868 SGTC_550 4123-0385 25.7 µM 0.308253733241254 0.369755184380252 no 1230 0.378944634236372 1753 5731123 SGTC_2197 6588183 93.1375 µM 0.307838607578979 0.369925235343899 no 1231 0.37910257128288 1802 884136 SGTC_3080 9117754 49.47 µM 0.305508950577911 0.370880020840735 no 1232 0.379989277026971 1879 9550191 SGTC_2594 a-mangostin 100 µM 0.305071891198812 0.371059233847157 no 1233 0.380155699471761 1890 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_2175 5807670 165.306 µM 0.304692911640489 0.371214654288965 no 1234 0.380300024383561 1875 241186 SGTC_2060 5238662 140 µM 0.304519168514341 0.371285913792901 no 1235 0.380366195692398 1750 790130 SGTC_2120 5538279 151.968 µM 0.303760532580901 0.37159711457861 no 1236 0.380655168593794 1792 2058197 SGTC_1961 st076550 68.7 µM 0.303606690471812 0.37166023254332 no 1237 0.380713776898716 1785 1579337 SGTC_1572 epiandrosterone 68.9 µM 0.302939347701527 0.371934068230496 no 1238 0.380968042145365 1822 441302 A steroid. SGTC_2870 9038528 12.99 µM 0.301756072654757 0.372419769440891 no 1239 0.38141900982863 1758 6463316 SGTC_1873 rapamycin 2 nM 0.301527053127362 0.372513799001333 no 1240 0.381506311963849 1744 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_761 k216-0224 480 µM 0.299590402732349 0.373309241442077 no 1241 0.382244802812011 1959 1340404 SGTC_2195 6536160 144.242 µM 0.299426534401194 0.373376572088361 no 1242 0.382307309405747 1751 3834386 SGTC_1913 st060213 96.1 µM 0.298657408176568 0.373692644299786 no 1243 0.38260072895436 1908 688959 SGTC_402 epigallocatechin gallate 10 µM 0.297413376662982 0.374204058496803 no 1244 0.383075466191458 1756 65064 An antioxidant. SGTC_144 4161-2749 112.381 µM 0.295482441274518 0.374998293279658 no 1245 0.3838126818495 1830 797501 YMR168C CEP3 SGTC_899 1083-0020 478 µM 0.294195407118533 0.375527972591211 no 1246 0.384304295013222 1901 767123 SGTC_1968 st069590 43.6 µM 0.293989092787815 0.375612903172476 no 1247 0.384383118989852 1879 6384066 SGTC_3335 9143315 29.6265 µM 0.293434214242506 0.375841352283073 no 1248 0.384595138317758 1772 4899691 SGTC_456 gingerol 170 µM 0.29234631510748 0.376289377621737 no 1249 0.385010925182452 1824 442793 A herb. SGTC_2221 6807166 181.081 µM 0.29036285497827 0.377106647187236 no 1250 0.385769328790364 1870 674925 SGTC_781 4335-2806 94.4 µM 0.290052284140675 0.377234665493472 no 1251 0.385888119507128 1914 845254 SGTC_1262 0737-0114 49.6 µM 0.289544104271191 0.377444167980336 no 1252 0.386082517082378 1938 765919 SGTC_2119 5528445 120.635 µM 0.287557458860206 0.378263529002808 no 1253 0.386842756427454 1895 791935 SGTC_1106 tegaserod maleate 11.7 µM 0.286715885453835 0.378610788255868 no 1254 0.387164936605456 1827 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_2989 9073649 71.4286 µM 0.285418520710813 0.379146313109255 no 1255 0.387661759962933 1947 21367202 SGTC_325 2810-4341 181 µM 0.283892464703324 0.379776533827248 no 1256 0.38824639566175 1921 774970 SGTC_204 PMA1.184 62.41 µM 0.282981835007542 0.380152752080319 no 1257 0.388595380842635 1823 2252213 YGL008C PMA1 SGTC_871 0574-0004 149 µM 0.28246220621363 0.380367482771191 no 1258 0.388794561110785 1809 9551173 SGTC_598 3937-0236 20.2 µM 0.28050372966058 0.38117713180011 no 1259 0.389545532211659 1874 1379313 SGTC_1501 4491-0275 38.4 µM 0.278899232398268 0.381840831117894 no 1260 0.390161078817447 1928 5104718 SGTC_1699 st031318 29.054 µM 0.278479753686654 0.382014405606623 no 1261 0.390322052408506 1887 5340658 SGTC_1306 1185-0270 9.02 µM 0.278366811615807 0.382061143527494 no 1262 0.390365396775142 1905 1548076 SGTC_1800 st050079 29.0735 µM 0.276524891339898 0.382823612904922 no 1263 0.391072472078032 1829 3645560 SGTC_2788 5282734 71.43 µM 0.274965794871597 0.383469361558167 no 1264 0.391671258736323 1925 743706 SGTC_116 0155-0182 31.788 µM 0.274657183590644 0.383597221041004 no 1265 0.391789814482324 1803 771486 SGTC_1311 1190-0148 100 µM 0.273343019774886 0.384141828660208 no 1266 0.392294774489878 1917 1961333 SGTC_973 1325-0077 65.9 µM 0.273295547119049 0.384161506272734 no 1267 0.392313018989245 1925 2835149 SGTC_939 1165-0479 45.3 µM 0.272772623308459 0.38437828010737 no 1268 0.392514002612061 1959 1377347 SGTC_1057 3448-5381 134 µM 0.271514399549973 0.384900014662923 no 1269 0.392997713142497 1921 5497911 SGTC_52 0329-0193 875 nM 0.270625141659611 0.385268879780235 no 1270 0.393339678456146 1918 3739292 SGTC_809 3998-0021 90 µM 0.270440286635395 0.385345570885994 no 1271 0.393410775044774 1950 715485 SGTC_727 3032-0951 202 µM 0.269117888562707 0.385894326933738 no 1272 0.393919482501569 1850 3652836 SGTC_2160 5660466 132.927 µM 0.269018571927309 0.385935549631893 no 1273 0.393957695498588 1955 2859134 SGTC_2226 7298446 200 µM 0.268474939710403 0.386161214265132 no 1274 0.394166881118705 1933 3283010 SGTC_2628 lathosterol 100 µM 0.265640355267882 0.387338487789731 no 1275 0.395258101414725 1837 6710616 SGTC_2411 st077133 39.94 µM 0.265366990555544 0.38745207795375 no 1276 0.395363381282325 1984 1403142 YNL221C POP1 SGTC_16 erodoxin 22.806 µM 0.265300866109526 0.387479555832426 no 1277 0.395388848675431 1885 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_1318 1280-3875 124 µM 0.264443276461467 0.387835976474771 no 1278 0.395719184091517 1868 373245 SGTC_2769 toremifene 3.73 µM 0.263052656504937 0.388414129270545 no 1279 0.396254996885708 1861 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2886 9058944 51.95 µM 0.262922852535943 0.388468108148355 no 1280 0.396305021019669 1839 4949929 SGTC_945 3381-0768 11.3 µM 0.262643674604604 0.388584211367417 no 1281 0.396412616997605 1959 1126236 YIL048W NEO1 SGTC_1988 st071872 53.4 µM 0.260955015682963 0.389286694832989 no 1282 0.397063598913574 1976 16414116 SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.259255228782718 0.389994173151256 no 1283 0.397719160457054 1927 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_682 0kpi-0099 17 µM 0.258213997222319 0.39042773048671 no 1284 0.398120877958509 1805 1714895 YML126C ERG13 SGTC_307 1501-1223 22.3 µM 0.257399622458882 0.390766922169854 no 1285 0.398435147152015 1865 2830329 SGTC_1506 4226-2149 212 µM 0.25608484887715 0.391314708125636 no 1286 0.398942660423012 1864 991114 SGTC_910 3454-3003 490 µM 0.255621095357072 0.391507977431583 no 1287 0.39912171385985 1996 820824 SGTC_270 tamoxifen 5.46 µM 0.255572043647894 0.391528421301345 no 1288 0.399140653776643 1975 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_2394 5221648 200 µM 0.255052209550433 0.391745097200929 no 1289 0.399341387452272 1938 788586 SGTC_2916 7875993 68.79 µM 0.254481755863346 0.391982910874189 no 1290 0.399561698484965 2037 1299250 SGTC_1855 st056195 39.6 µM 0.253711832822514 0.392303944340789 no 1291 0.399859095922012 1983 4028379 SGTC_2550 chrysin dimethyl ether 71.87 µM 0.253245129510613 0.392498580508624 no 1292 0.400039397257543 1885 88881 An O-methylated flavonoid and antioxidant. SGTC_3079 9117512 49.47 µM 0.250370238163818 0.393698130152711 no 1293 0.401150521651949 1905 7185044 SGTC_1626 st003712 1.76 µM 0.250314225513062 0.39372151151735 no 1294 0.401172178103902 1899 24207035 SGTC_684 1140-0066 328 µM 0.250205741003193 0.393766797303389 no 1295 0.401214122877275 1841 6813534 SGTC_588 3970-1144 52.9 µM 0.247432310082856 0.394925024884304 no 1296 0.402286835782954 1953 1888707 SGTC_341 1486-1430 230 µM 0.246712504904283 0.395225778927249 no 1297 0.402565364077197 1813 2054753 YPL210C SRP72 SGTC_81 0411-0046 9.971 µM 0.24620567783686 0.39543758242621 no 1298 0.40276151027148 1903 12925265 SGTC_911 3456-4043 236 µM 0.244420059436494 0.396184039729926 no 1299 0.403452753818236 1923 914281 SGTC_586 0957-0265 8.15 µM 0.244348938872722 0.396213778769591 no 1300 0.40348029207225 2001 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_1359 1582-0056 520 nM 0.243166864752944 0.396708150977725 no 1301 0.403938067328946 1919 3661189 SGTC_1677 st019204 53.9 µM 0.242711200283641 0.396898765357363 no 1302 0.404114565144112 1812 3945625 SGTC_1496 4469-0713 57.4 µM 0.242612749677569 0.396939952629744 no 1303 0.404152701727317 1966 746691 SGTC_1075 aripiprazole 15.2 µM 0.241104151575181 0.397571225229476 no 1304 0.404737197595553 1856 60795 An atypical antipschotic. YIL048W NEO1 SGTC_1760 st045453 10.4495 µM 0.240334615939461 0.397893340733348 no 1305 0.405035430814735 2010 3323419 YIL048W NEO1 SGTC_1190 1486-1332 13 µM 0.24031683419783 0.397900784714222 no 1306 0.405042322774078 1931 4150046 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 0.23912745001428 0.398398781570427 no 1307 0.405503378546871 1983 688662 SGTC_2038 4100038 30.985 µM 0.238234829460652 0.398772631837495 no 1308 0.405849482326386 1903 3596803 SGTC_1505 k297-0037 20.6 µM 0.238152977515025 0.398806917992655 no 1309 0.405881223204256 1849 4089396 SGTC_913 3487-1245 167 µM 0.237134969388747 0.399233406560043 no 1310 0.406276042142913 1821 4016153 SGTC_1365 1672-3266 55.4 µM 0.236478577295365 0.399508462023876 no 1311 0.406530664384084 2004 6415873 SGTC_1925 st057770 10.1 µM 0.236430998130622 0.399528401604472 no 1312 0.40654912244135 1748 5989122 SGTC_3347 9188721 44.724 µM 0.236061719678486 0.399683168533472 no 1313 0.406692388902735 1934 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_1594 piperine 70.1 µM 0.234685265052447 0.400260188044847 no 1314 0.407226512577339 1841 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_76 0433-0009 400.328 µM 0.233097124401875 0.400926218377113 no 1315 0.407842993902689 1848 2841569 SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.233073128442821 0.400936283954565 no 1316 0.407852310361235 1972 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_738 1315-0003 72.4 µM 0.233001906970556 0.400966159590538 no 1317 0.407879962486108 1990 6251474 SGTC_2838 9002687 71.43 µM 0.231690596424319 0.401516325070807 no 1318 0.408389167820047 1810 6457060 SGTC_675 1309-0189 238 µM 0.230534007403576 0.40200173864812 no 1319 0.408838420467621 1872 4246530 SGTC_200 k038-0079 37.545 µM 0.230518255888715 0.402008350511113 no 1320 0.408844539640032 1936 3436683 SGTC_1665 st014639 11.4 µM 0.230244531267587 0.402123253758117 no 1321 0.408950880143142 1941 981133 YIL048W NEO1 SGTC_51 1013-0126 23.419 µM 0.229839065204733 0.402293474549645 no 1322 0.409108413783304 2065 1627850 SGTC_2078 5212016 200 µM 0.227237688971348 0.403386011160052 no 1323 0.41011946129145 2041 1899708 SGTC_1128 3448-9350 235 µM 0.226810127191929 0.403565652721845 no 1324 0.410285694275604 1840 619386 SGTC_1841 st054148 70 µM 0.225858863232411 0.403965402509752 no 1325 0.410655596740741 1863 675442 SGTC_1394 3474-0001 65.7 µM 0.225736561193505 0.404016804799338 no 1326 0.41070316010834 1894 5017666 YIL048W NEO1 SGTC_1208 2323-2347 50.3 µM 0.224769549052358 0.404423288351635 no 1327 0.411079278141174 2053 5412760 SGTC_905 2-aminofluorene 215 µM 0.223223788992827 0.405073262733243 no 1328 0.411680669038509 1912 1539 An established DNA mutagen. YPR165W RHO1 SGTC_1757 st041620 31.8375 µM 0.222897064478286 0.405210680239779 no 1329 0.411807810563781 1875 5289815 SGTC_1439 4092-1168 46 µM 0.222866329697783 0.40522360762444 no 1330 0.411819771168034 1965 2886240 SGTC_2647 atorvastatin 60.16 µM 0.220720485620398 0.406126427971209 no 1331 0.412655039801436 1988 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_2801 7907800 81.82 µM 0.21984932393514 0.406493094370607 no 1332 0.412994252150079 1897 6620925 SGTC_981 1488-1094 54.9 µM 0.219235011553683 0.406751703857455 no 1333 0.413233491767606 1918 3449522 SGTC_2176 5809774 33.9695 µM 0.218966508357785 0.406864749477634 no 1334 0.41333806856545 2054 2870539 SGTC_2431 5490079 200 µM 0.2183835151379 0.407110228867676 no 1335 0.413565154299568 1882 5722345 SGTC_618 k072-0232 33.2 µM 0.218330769526362 0.407132440122327 no 1336 0.413585701036081 1936 5872756 YGL099W LSG1 SGTC_213 1246-0773 967 nM 0.215533323495958 0.40831087500431 no 1337 0.414675767061957 1969 6251622 SGTC_375 3970-0961 9.27 µM 0.215479323989923 0.408333630700038 no 1338 0.414696815258423 1942 2898222 SGTC_1929 genistein trimethyl ether 50.5 µM 0.215040904783258 0.408518394457414 no 1339 0.414867713541931 2079 136420 SGTC_1196 1588-0294 184 µM 0.212868270706815 0.409434310692128 no 1340 0.415714855741595 1894 6144269 SGTC_369 0957-0393 4.5 µM 0.212585580914898 0.409553520550091 no 1341 0.415825109570822 1855 6997992 SGTC_178 4092-0806 87.505 µM 0.2123740931247 0.409642710100706 no 1342 0.415907597741035 2001 2169044 SGTC_1923 st058458 19.1 µM 0.211712526352271 0.409921739089728 no 1343 0.416165657501078 2050 3534982 SGTC_1253 0550-0034 176 µM 0.20973431737072 0.410756359833844 no 1344 0.416937519896821 1928 5969915 SGTC_3260 9137109 49.47 µM 0.209540497474891 0.410838155660314 no 1345 0.417013162291323 2052 17478346 SGTC_1954 st077032 68.9 µM 0.209041822343476 0.41104862423427 no 1346 0.417207795130277 1822 698907 SGTC_420 mitomycin C 81.9 mM 0.208180963673527 0.411412014585293 no 1347 0.417543835877856 1919 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1911 st060208 74.3 µM 0.208006019410519 0.411485872313839 no 1348 0.417612133670059 2005 688783 SGTC_2153 5569715 200 µM 0.207588854129428 0.411662003232172 no 1349 0.417775003952918 1963 2054701 SGTC_1811 st050069 61.5 µM 0.2074729617676 0.411710937186582 no 1350 0.41782025332405 2084 3877702 SGTC_2077 5212015 200 µM 0.207461540035944 0.41171575992989 no 1351 0.417824712919087 2019 780900 SGTC_3091 9116372 49.47 µM 0.207305352603041 0.411781710277879 no 1352 0.417885697087601 1959 17169793 SGTC_2355 9061122 103.12 µM 0.207081042197273 0.411876429999509 no 1353 0.417973283667342 2028 5302957 SGTC_3242 9133940 49.47 µM 0.206993114020762 0.411913560897116 no 1354 0.418007618130133 2005 17248444 SGTC_497 capsazepine 133 µM 0.205256243883686 0.412647179266714 no 1355 0.418685964247643 1840 2733484 A calcium channel blocker. SGTC_1482 3346-2049 8.48 µM 0.204852203185011 0.412817881638444 no 1356 0.418843799764017 2023 3826804 SGTC_832 4083-0019 164 µM 0.202333599988949 0.413882331920161 no 1357 0.41982796707906 2021 1990758 SGTC_1171 0368-0077 21.4 µM 0.201835308205531 0.414093002810021 no 1358 0.420022738799716 1924 3239779 SGTC_2265 7929201 200 µM 0.201215536622987 0.414355068174076 no 1359 0.42026502173527 1965 1265108 SGTC_898 1000-0849 28.3 µM 0.200910624277782 0.414484011877249 no 1360 0.420384230064043 2067 6751807 SGTC_2981 9013952 38.96 µM 0.200401844809587 0.414699189007344 no 1361 0.420583158402584 1825 2996344 SGTC_2960 9079389 5.97 µM 0.199949332059472 0.414890590871918 no 1362 0.420760103989241 2048 16457355 SGTC_3171 9103192 49.47 µM 0.198538767424359 0.415487354792512 no 1363 0.421311778184007 2084 13018434 SGTC_121 0557-0495 61.343 µM 0.196333173174245 0.416420860156367 no 1364 0.422174699095833 1930 3104427 SGTC_385 1494-0393 12.4 µM 0.195611640365795 0.416726347493756 no 1365 0.422457074301622 1991 3090647 SGTC_1245 0418-0076 17.2 µM 0.19554435308169 0.41675483859627 no 1366 0.422483409525803 1964 6790114 SGTC_2836 9010338 19.48 µM 0.19536609349003 0.416830320235413 no 1367 0.422553179305568 1823 2994051 SGTC_1436 4092-1007 8.32 µM 0.194909487126788 0.417023678070551 no 1368 0.422731903490284 1980 2881121 SGTC_2228 7354201 200 µM 0.194769238825223 0.417083072662978 no 1369 0.422786802467127 2015 753451 SGTC_380 3970-0968 6 µM 0.194702152566763 0.417111484093176 no 1370 0.422813063329341 1940 2891601 SGTC_935 2996-0153 430 µM 0.193501912910995 0.417619865749544 no 1371 0.423282954040611 2090 23738523 SGTC_1396 3511-0007 98.6 µM 0.192988992610905 0.417837163806459 no 1372 0.423483794332878 1952 X1396 SGTC_3298 9116858 71.43 µM 0.190913327205185 0.418716772431365 no 1373 0.424296749309506 2030 2506942 SGTC_591 4299-0174 154 µM 0.189308373798551 0.419397185497648 no 1374 0.42492556632475 2007 5509088 SGTC_827 3253-0474 693 µM 0.188901400781197 0.419569758349309 no 1375 0.425085047839059 2075 5402065 SGTC_2091 4-phenylthiadiazole 200 µM 0.187923165121124 0.419984632654317 no 1376 0.425468441553563 1971 270010 SGTC_1464 k208-0027 110 µM 0.187190328523434 0.420295490366032 no 1377 0.425755703766605 2058 X1464 SGTC_1690 st023502 41.2 µM 0.187086653270501 0.420339471790235 no 1378 0.425796346274232 2075 24207482 SGTC_2915 7971052 15.16 µM 0.184994329752561 0.421227295357707 no 1379 0.426616741508358 2071 5741558 SGTC_904 1141-0088 396 µM 0.18496904554603 0.421238026518479 no 1380 0.426626657336746 1890 1378119 SGTC_2369 9071472 200 µM 0.181808695260424 0.422579805293167 no 1381 0.42786643021119 1998 17296037 SGTC_3070 9117005 49.47 µM 0.181047377245092 0.422903170328991 no 1382 0.42816519438302 2092 8779016 SGTC_1901 st060216 58.6 µM 0.180876791580864 0.42297563264856 no 1383 0.428232143000887 2010 688792 SGTC_142 0335-0849 62.6745 µM 0.18049915671027 0.423136055738918 no 1384 0.428380358185372 2021 3889043 YPR107C YTH1 SGTC_3133 9127736 49.47 µM 0.180471723816598 0.423147710004875 no 1385 0.42839112551766 2133 27243420 SGTC_66 0109-0187 42.4 µM 0.180205975427179 0.423260610885864 no 1386 0.42849543375855 1941 759417 SGTC_941 3237-0776 460 µM 0.180125239655057 0.423294912021612 no 1387 0.428527124145795 2066 760008 SGTC_1298 1079-1278 263 µM 0.179872478749065 0.423402302950447 no 1388 0.428626340779216 1972 2840950 SGTC_2871 9038510 12.99 µM 0.177968306848898 0.424211513868805 no 1389 0.429373932919343 2114 4945164 SGTC_351 caspofungin 25 nM 0.177696129402144 0.424327206588156 no 1390 0.429480812581226 2017 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_3025 9087895 49.47 µM 0.177279041536159 0.424504508097859 no 1391 0.4296446062384 2097 17173641 SGTC_763 3453-1109 128 µM 0.177012614431822 0.424617772634621 no 1392 0.429749240580724 2104 1560353 SGTC_2246 7293507 91.5585 µM 0.1761419533956 0.424987954833345 no 1393 0.430091211055573 2121 887656 SGTC_2437 5741531 144.16 µM 0.176104628241195 0.425003825989521 no 1394 0.430105872470971 2093 2262990 SGTC_736 0958-0254 92.6 µM 0.174669648887183 0.425614090387697 no 1395 0.430669608889988 2043 6812352 SGTC_766 1391-0721 126 µM 0.174655427071927 0.425620139499775 no 1396 0.430675196686564 2077 1020919 YIL115C NUP159 SGTC_219 mitoxanthrone 164.414 µM 0.174407468450731 0.425725609122176 no 1397 0.430772622649341 2068 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_3134 9127454 49.47 µM 0.173881535589875 0.42594933314234 no 1398 0.430979282015862 2137 24262820 SGTC_698 k064-0052 127 µM 0.17289446108675 0.426369284258683 no 1399 0.431367192751142 2083 5088751 SGTC_651 3253-0966 34.4 µM 0.171946707762613 0.426772584752542 no 1400 0.431739712950682 2000 781462 SGTC_47 0149-0135 24.25 µM 0.169909861494188 0.427639589011359 no 1401 0.432540512770916 1961 5239155 SGTC_2040 5100729 123 µM 0.169841108522029 0.427668860532634 no 1402 0.432567548318937 2027 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_1427 4048-4900 550 nM 0.16975233591841 0.427706655984387 no 1403 0.432602456600238 2121 24132586 SGTC_510 ag-490 170 µM 0.169742377068892 0.427710896063821 no 1404 0.432606372777301 2142 5328779 SGTC_3232 9132874 49.47 µM 0.169078621849462 0.427993515261032 no 1405 0.432867400058199 1968 3784940 SGTC_3256 9138902 49.47 µM 0.168876126461527 0.428079742786261 no 1406 0.432947038897065 2101 17228773 SGTC_958 1222-0007 33 µM 0.167637721417986 0.428607160744193 no 1407 0.433434146857862 2061 7312461 SGTC_2154 5570129 200 µM 0.166575560641103 0.429059620570522 no 1408 0.43385201239002 2094 673366 SGTC_2732 terfenadine 20 µM 0.166147552069625 0.429241970281802 no 1409 0.434020416515205 2126 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_2829 7992743 58.44 µM 0.16485560687531 0.429792484878499 no 1410 0.43452881739861 2159 16462845 SGTC_2743 auranofin 4.32 µM 0.163804451094558 0.43024049677308 no 1411 0.434942543773103 2076 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_2069 5228469 200 µM 0.163465369817689 0.430385035401722 no 1412 0.43507601862751 2010 2835210 SGTC_681 1642-0006 26.6 µM 0.162335183155347 0.430866862165416 no 1413 0.435520954983158 2115 4446530 SGTC_696 1560-0013 611 µM 0.161308793818796 0.431304526738433 no 1414 0.435925098748774 2084 1650269 SGTC_488 nitrendipine 139 µM 0.15973597878875 0.431975357202873 no 1415 0.436544528905721 2092 4507 Dihydropyridine L-type calcium channel blocker. SGTC_970 1315-0089 19.5 µM 0.158969519628974 0.432302335365544 no 1416 0.436846444113513 2103 6811083 YLR033W RSC58 SGTC_907 3448-6986 75.5 µM 0.15841449058683 0.432539144557814 no 1417 0.437065098058158 2115 590582 SGTC_1502 4534-4282 27.7 µM 0.15828871722218 0.432592810506162 no 1418 0.437114649206951 2024 3278949 SGTC_841 0251-0215 91.2 µM 0.158098099152457 0.432674147262973 no 1419 0.437189749216001 2062 3888614 SGTC_32 0928-0142 34.1 µM 0.158024823769224 0.432705414638456 no 1420 0.437218618969936 2120 2244242 SGTC_67 0335-0847 266 µM 0.15715125730018 0.43307820702577 no 1421 0.437562820958901 2148 4552207 YOR254C SEC63 SGTC_1982 st072467 71.9 µM 0.156841459683284 0.433210426736595 no 1422 0.437684898542062 1984 3163533 SGTC_2646 retinol 96.75 µM 0.156625847275981 0.43330245319459 no 1423 0.437769865387863 2080 445354 A vitamin A analog and teratogen. SGTC_1260 0700-1617 7.75 µM 0.156362561017214 0.433414832437948 no 1424 0.437873623061864 2030 2853078 SGTC_3193 9111931 49.47 µM 0.15524694677607 0.433891072956129 no 1425 0.438313319368606 2031 17087244 SGTC_1273 0849-0096 14.1 µM 0.155161797309046 0.43392742605453 no 1426 0.438346882407071 2007 5286025 SGTC_1043 0916-0009 19.3 µM 0.154953214462462 0.434016479269037 no 1427 0.438429100579878 2187 3101130 SGTC_500 h-89 112 µM 0.154317234686166 0.434288027733114 no 1428 0.438679804386385 2145 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_2281 7943571 200 µM 0.15326996091835 0.434735256611142 no 1429 0.439092694232864 2181 1244024 SGTC_80 0159-0065 512.242 µM 0.152933850558786 0.434878807260014 no 1430 0.439225220507187 2143 1548079 SGTC_3137 9097352 49.47 µM 0.15224852528275 0.435171532009774 no 1431 0.439495461193703 2097 44120435 SGTC_3006 9075424 71.4286 µM 0.151721403639837 0.43539670701823 no 1432 0.439703337471438 2001 7465181 SGTC_1539 benzyladenosine 56 µM 0.150734623464099 0.435818294508825 no 1433 0.440092529849345 2064 92208 A nucleotide analog. SGTC_530 4358-1714 28 µM 0.150572356152171 0.435887627856261 no 1434 0.440156534661965 2078 1564641 SGTC_2028 5153890 36.43 µM 0.149642682463954 0.436284895434196 no 1435 0.440523265786777 2040 2830968 YPR165W RHO1 SGTC_1136 pergolide 1.05886 µM 0.149625161852321 0.436292382949383 no 1436 0.440530177685001 1989 47811 A dopamine receptor agonist. SGTC_1286 0929-0070 131 µM 0.147535113334896 0.437185737991118 no 1437 0.441354833263803 2085 1420408 SGTC_1928 4'-methoxychalcone 40.3 µM 0.147270650226926 0.437298801094387 no 1438 0.441459198791074 2187 641818 SGTC_2737 bleomycin 30.5 nM 0.146118776910754 0.43779130886124 no 1439 0.441913811837552 2117 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_2741 miltefosine 3.04 µM 0.14539402586923 0.438101240929386 no 1440 0.442199890605693 2085 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_98 0074-0023 107.663 µM 0.143853180818549 0.438760292864508 no 1441 0.442808203668716 2000 3563821 SGTC_2258 7960471 200 µM 0.143009005805969 0.439121436455398 no 1442 0.44314153434943 1997 2974708 SGTC_2024 5144227 134 µM 0.142934093674914 0.439153486807633 no 1443 0.443171116077485 2114 3475211 SGTC_156 3474-0145 5.642 µM 0.142660836546182 0.4392704003208 no 1444 0.443279024089235 2175 2265471 SGTC_166 k072-0058 166.424 µM 0.142597670315999 0.439297426850772 no 1445 0.443303968748467 2184 5846229 SGTC_1562 morin hydrate 59.1 µM 0.1424664217329 0.439353584245285 no 1446 0.443355800186656 2056 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_2482 5981709 142.65 µM 0.14080504442167 0.440064543690915 no 1447 0.444011978949756 2086 877755 SGTC_2395 5646831 180.19 µM 0.139841977878353 0.440476761033938 no 1448 0.444392422798624 2090 6808628 SGTC_355 1311-2252 105 µM 0.139035228059756 0.44082212046118 no 1449 0.444711155710196 2010 5338538 SGTC_2670 beta-carotene 100 µM 0.136777480917267 0.441788871992109 no 1450 0.44560334197928 2154 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_2446 5162541 200 µM 0.13654782820692 0.441887227207619 no 1451 0.445694108575678 2054 1549321 SGTC_867 0518-0118 155 µM 0.134578310414845 0.442730874958936 no 1452 0.446472645679996 2200 6848158 SGTC_1875 nocodazole 6 µM 0.133606726701676 0.443147151123594 no 1453 0.446856782372955 2194 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_176 1486-1328 72.834 µM 0.131606081027666 0.444004527240488 no 1454 0.447647937701418 2065 22310231 SGTC_655 k060-0012 42 µM 0.130508763734835 0.444474893821127 no 1455 0.448081960493403 2066 5994525 SGTC_2789 5281112 71.43 µM 0.130469021819369 0.444491930719852 no 1456 0.448097680814724 2036 765948 SGTC_1324 1418-0026 34.4 µM 0.130184092148387 0.444614079770248 no 1457 0.448210390047264 2092 1372513 SGTC_2217 6934799 96.0675 µM 0.129518908552647 0.444899263732675 no 1458 0.448473532052144 2169 675606 SGTC_2716 st080858 38.6235 µM 0.129493323822896 0.444910233236702 no 1459 0.448483653646829 2178 5296050 SGTC_1410 3909-8106 77.9 µM 0.129081105713904 0.445086978384856 no 1460 0.44864673618926 2163 1039210 SGTC_1242 0402-0103 60.1 µM 0.129032403693946 0.445107860881441 no 1461 0.448666004352302 2133 432868 SGTC_1722 st034304 3.6505 µM 0.128830219106451 0.445194555401654 no 1462 0.448745996694152 2073 4036148 YLR033W RSC58 SGTC_386 1509-0011 3.07 µM 0.127574270631837 0.445733150803875 no 1463 0.449242946892799 2115 3107280 SGTC_2939 9044578 71.43 µM 0.125567043086188 0.446594128958234 no 1464 0.450037326112893 2132 2653634 SGTC_2466 5983409 37.09 µM 0.124249858200188 0.447159258009088 no 1465 0.450558723458822 2068 2879657 SGTC_837 0091-0265 12.5 µM 0.124231604968454 0.447167090188169 no 1466 0.450565949459544 2051 759367 SGTC_2713 st079149 53.4 µM 0.12399967421426 0.447266609876442 no 1467 0.450657766506072 2096 3103253 SGTC_1996 st072960 66.8 µM 0.121462948223294 0.4483553147513 no 1468 0.451662180202845 2211 1719405 SGTC_2804 7954240 19.48 µM 0.121386802386496 0.448388000861526 no 1469 0.451692334874949 2157 828705 SGTC_1773 st048542 73.5835 µM 0.120234095527912 0.448882850670027 no 1470 0.452148854676304 2019 3237138 SGTC_1103 duloxetine 36.1 µM 0.119839776565354 0.449052147616867 no 1471 0.452305035921157 2172 60835 A selective serotonin reuptake inhibitor. SGTC_3116 9124943 49.47 µM 0.119637826102551 0.449138856644743 no 1472 0.452385027007562 1986 41905195 YPL160W CDC60 SGTC_2386 9075165 157.42 µM 0.119637175263673 0.44913913609149 no 1473 0.452385284803159 2106 16452277 SGTC_660 4031-1742 102 µM 0.118904359184779 0.449453796866284 no 1474 0.452675564067943 2098 6738706 SGTC_590 k048-0076 22.4 µM 0.118551605798682 0.449605275486169 no 1475 0.452815303918627 2206 6832814 SGTC_1467 k284-1082 293 µM 0.118454180763924 0.449647112835616 no 1476 0.452853898936849 2218 3334705 SGTC_2596 sinensetin 100 µM 0.118355765036885 0.449689376187526 no 1477 0.452892886870961 2101 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_1711 st032263 62.8 µM 0.117604501899294 0.450012015126343 no 1478 0.453190518852191 2119 3958979 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.117316049567023 0.450135903220994 no 1479 0.453304803569085 2161 5357218 A potent inhibitor of glutathione S-transferases. SGTC_3352 9151559 45.5865 µM 0.116781783462365 0.450365379298137 no 1480 0.453516489828224 2109 17159339 SGTC_719 2810-4230 27.3 µM 0.116671818463488 0.450412613135184 no 1481 0.453560061665883 2184 721079 SGTC_3183 9108214 49.47 µM 0.116168932537248 0.450628629279107 no 1482 0.453759329129794 2192 4974831 SGTC_2653 dihydrofissinolide 100 µM 0.115699305108047 0.450830372344717 no 1483 0.453945428499036 2132 6857746 SGTC_49 0717-0965 32.132 µM 0.115479245759646 0.450924910054816 no 1484 0.454032634949374 2147 5889349 YGL099W LSG1 SGTC_2082 5219693 150 µM 0.114908144776985 0.451170268566993 no 1485 0.454258964631323 2166 2834649 SGTC_636 0kpi-0074 126 µM 0.114019775215823 0.451551970227155 no 1486 0.454611058659056 2097 616434 SGTC_2586 curcumin 80 µM 0.112564427250522 0.452177379533206 no 1487 0.455187944346769 2180 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_522 1273-0010 11.6 µM 0.111748750435923 0.452527953801965 no 1488 0.455511312059491 2130 5705015 SGTC_2073 5212005 126 µM 0.110594696050005 0.453024024410559 no 1489 0.455968876811936 2246 691789 SGTC_2426 5582046 32.21 µM 0.110049394988779 0.453258447783003 no 1490 0.45618510062131 2193 2251934 SGTC_891 0929-0073 133 µM 0.109553049825356 0.453471839318048 no 1491 0.456381923627889 2173 5603632 SGTC_1122 capsaicin 818.572 nM 0.108548517307426 0.453903754696224 no 1492 0.456780298297955 2139 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_2310 7668677 200 µM 0.10814170040244 0.454078687896276 no 1493 0.456941644978939 2162 2197143 SGTC_745 0469-0705 296 µM 0.107622268922171 0.454302058842838 no 1494 0.457147665771958 2221 3486736 SGTC_1388 3346-4487 254 µM 0.107244197886225 0.454464649697143 no 1495 0.457297626375243 2151 3345614 SGTC_389 tpck 16.7 µM 0.105530797607436 0.455201599102255 no 1496 0.457977316733024 2120 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_1244 0416-0015 52.5 µM 0.105173203185002 0.455355423323823 no 1497 0.458119186767097 2125 96201 SGTC_1302 1159-0335 255 µM 0.104688149816149 0.455564086479641 no 1498 0.458311632682907 2147 649284 SGTC_3166 9102297 49.47 µM 0.104109278473554 0.455813124851349 no 1499 0.458541313858428 2109 25237072 SGTC_3101 9120531 49.47 µM 0.103448062736824 0.456097610144793 no 1500 0.458803684091201 2222 24824904 SGTC_2384 9036245 200 µM 0.102932993467408 0.456319232137573 no 1501 0.459008075884772 2174 6462766 SGTC_1746 st038117 42 µM 0.102626687150937 0.456451034870831 no 1502 0.459129630692151 2121 2898218 SGTC_2612 dictamnine 15.46 µM 0.102329866383672 0.45657876057087 no 1503 0.459247424893325 2115 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_3157 9099274 49.47 µM 0.10222538802925 0.456623719985737 no 1504 0.459288888289787 2228 17217662 SGTC_1948 st076329 66.6 µM 0.101104909317198 0.457105922282848 no 1505 0.459733590473592 2241 24208413 SGTC_1646 st011709 75.6 µM 0.100120617152234 0.457529568315078 no 1506 0.460124283725991 2237 5757843 SGTC_999 SEC7.066 22.7 µM 0.0999510431844188 0.457602558989355 no 1507 0.460191596303195 2157 740511 YDR170C SEC7 SGTC_174 3553-0389 74.3 µM 0.0997895178725701 0.457672086565355 no 1508 0.460255715018346 2181 738071 SGTC_2449 5812982 45.77 µM 0.0996886891966629 0.457715488304938 no 1509 0.460295740260958 2228 776185 SGTC_396 dithiazanine 1.25 µM 0.0993977513048443 0.457840725449313 no 1510 0.460411234061224 2080 10578 An antihelmenthic. SGTC_2661 dactinomycin 12.96 µM 0.0991763860241356 0.457936017167688 no 1511 0.460499111815672 2230 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_2947 9072639 7.68 µM 0.098357996949805 0.458288332303844 no 1512 0.460824013239368 2157 16488146 SGTC_2056 5235370 200 µM 0.0961855648618912 0.459223718937146 no 1513 0.461686597613416 2131 5511916 SGTC_1608 st001473 40.5 µM 0.0960425593934258 0.459285300946572 no 1514 0.461743385632964 2064 7292267 SGTC_3175 9106517 49.47 µM 0.0956013304334067 0.459475312180886 no 1515 0.461918604254582 2137 41468073 SGTC_2717 st081029 62.2815 µM 0.0948997690155899 0.459777452261635 no 1516 0.462197219995746 2242 5292846 SGTC_1021 4476-0760 85.3 µM 0.0947168126144532 0.459856249562298 no 1517 0.462269881740473 2106 746768 SGTC_2665 lovastatin 100 µM 0.0944871542605168 0.459955163109583 no 1518 0.4623610931035 2166 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_3072 9116419 49.47 µM 0.0934349839618407 0.460408363051748 no 1519 0.46277899944369 2148 17170162 SGTC_233 rapamycin 362 pM 0.0921237335189036 0.460973228173951 no 1520 0.463299866004976 2243 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_1341 1486-1360 280 µM 0.0904735619245247 0.461684206732623 no 1521 0.46395545115184 2206 3976547 SGTC_1224 0823-0416 294 µM 0.0900601560765894 0.46186234244726 no 1522 0.464119705675765 2226 3598164 SGTC_638 3970-0837 4.09 µM 0.0898239449420334 0.461964128767692 no 1523 0.464213559895192 2160 4118451 YLR208W SEC13 SGTC_2740 felodipine 17.08 µM 0.0893475285353872 0.462169430104495 no 1524 0.464402861385515 2262 3333 L-type calcium channel blocker SGTC_2533 agelasine 13.65 µM 0.0891575845786576 0.462251285154119 no 1525 0.464478336841714 2247 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_2406 ethylparaben 405.7 µM 0.088952786202265 0.46233954340543 no 1526 0.464559716229318 1894 8434 A possible steroid mimic. SGTC_688 0527-0193 473 µM 0.0888053659585664 0.462403075588941 no 1527 0.464618296562538 2166 4007154 SGTC_2465 5809242 33.21 µM 0.0880589429231114 0.462724768523772 no 1528 0.46491491418176 2241 2731748 SGTC_1389 3405-0187 19 µM 0.0879446847927039 0.462774013578542 no 1529 0.464960320419792 2139 799890 SGTC_317 4495-0002 170 µM 0.0875041746579796 0.462963878011097 no 1530 0.465135383632367 2113 15991618 SGTC_2819 7996655 46.38 µM 0.0870978715211041 0.463139006354264 no 1531 0.465296858619011 2233 6456960 SGTC_1792 st045773 43.6 µM 0.0859669821457748 0.463626489726302 no 1532 0.465746332229416 2136 2919270 SGTC_1932 st074806 40.9 µM 0.0858878485178368 0.463660603274914 no 1533 0.465777785646312 2184 17251235 SGTC_793 0488-0545 106 µM 0.0857059703225569 0.463739009774526 no 1534 0.465850077982032 2074 292548 SGTC_798 1287-0182 476 µM 0.0852339272047622 0.463942511036834 no 1535 0.466037709350926 2248 1649755 SGTC_1791 st048313 56.1 µM 0.0849002381392173 0.464086372543735 no 1536 0.466170351232362 2275 1204976 SGTC_1616 st002734 56.1 µM 0.0837511231842969 0.464581819880268 no 1537 0.466627154733408 2157 4026101 SGTC_3149 9097855 49.47 µM 0.0827968763102054 0.464993290527478 no 1538 0.467006526472175 2252 25236625 YMR079W SEC14 SGTC_403 arphamenine a 50 µM 0.0827850709665768 0.464998381219498 no 1539 0.467011220009724 2222 5487158 An arginine aminopeptidase inhibitor. SGTC_2750 bromebric acid 70.15 µM 0.0812377790653445 0.465665652620506 no 1540 0.467626427720663 2192 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_2762 leflunomide 42.06 µM 0.0782696794668825 0.466945917590066 no 1541 0.46880676786585 2212 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_2237 6667747 47.222 µM 0.0780125726504308 0.467056834755693 no 1542 0.468909025972358 2119 729940 YDL015C TSC13 SGTC_2667 digitoxin 100 µM 0.0777529961660905 0.46716881994352 no 1543 0.469012268411083 2286 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_271 rotenone 740 µM 0.0769716809541758 0.467505906689653 no 1544 0.469323036719217 2216 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_1883 5-benzylidenerhodanine 20 µM 0.0762068168921048 0.467835918407947 no 1545 0.46962727968369 2285 1273210 SGTC_215 1287-0124 461.5 µM 0.0759443691897936 0.467949160389812 no 1546 0.469731678626484 2270 5560863 SGTC_1003 4049-0218 100 µM 0.0757957464956524 0.468013289853806 no 1547 0.469790800098395 2226 295161 SGTC_2874 9043904 71.43 µM 0.0756631249961899 0.468070515635476 no 1548 0.469843556925864 2143 4463428 SGTC_95 0471-0001 561.058 µM 0.0754118929883865 0.468178923305796 no 1549 0.469943498459626 2111 4015405 SGTC_1937 st074714 47.2 µM 0.073783350891737 0.468881702956255 no 1550 0.470591387487652 2266 17250970 SGTC_1180 1193-0155 285 µM 0.073402127491454 0.469046229861095 no 1551 0.47074306233553 2196 2921347 SGTC_3274 9138298 49.47 µM 0.0732725118075491 0.469102170096821 no 1552 0.470794632643465 2290 17015756 SGTC_1282 0886-0010 32.4 µM 0.0723561842822956 0.469497661005999 no 1553 0.471159226615289 2270 2836211 YNL267W PIK1 SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.0722851563162008 0.469528318244139 no 1554 0.471187488668108 2270 140250 A respiratory chain inhibitor. SGTC_3044 9093193 49.47 µM 0.0716755521576759 0.469791444266047 no 1555 0.471430056330534 2184 25236277 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.0715804876363085 0.469832478559533 no 1556 0.471467884422986 2209 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_2264 7948757 110.76 µM 0.0713020699433225 0.469952658498723 no 1557 0.471578673924069 2281 2971411 SGTC_1492 4158-0558 28.5 µM 0.0709608908818441 0.470099933326125 no 1558 0.471714440772482 2261 3967268 SGTC_22 0964-0034 14.468 µM 0.0696041346997824 0.470685636837334 no 1559 0.472254372955209 2237 138402 SGTC_2152 5568786 200 µM 0.069113616206561 0.470897406406018 no 1560 0.472449591390207 2280 5399883 SGTC_717 1532-0246 73.2 µM 0.0675033163089112 0.471592672216901 no 1561 0.47309051100841 2213 9561992 SGTC_2334 9017922 200 µM 0.0671276623326593 0.471754877746701 no 1562 0.47324003610025 2269 3163164 SGTC_1897 st060201 15 µM 0.0671252829843203 0.471755905152511 no 1563 0.473240983186728 2117 611878 SGTC_776 4476-4378 112 µM 0.06627384058701 0.472123571139227 no 1564 0.473579904806412 2146 2892008 SGTC_3209 9113616 49.47 µM 0.0659722729190655 0.472253798432267 no 1565 0.473699950177331 2307 16649353 SGTC_585 0kpi-0023 191 µM 0.0656089421312387 0.472410701103536 no 1566 0.473844584831999 2278 64601 SGTC_2877 9040724 71.43 µM 0.0655982025245719 0.47241533901682 no 1567 0.473848860105246 2298 6463895 SGTC_352 k048-0007 5.11 µM 0.0655697078947984 0.472427644478341 no 1568 0.47386020339638 2271 6811911 SGTC_628 1636-0253 16 µM 0.0642451853240223 0.47299967098465 no 1569 0.474387499498963 2269 4456143 SGTC_441 propafenone 146 µM 0.062252342375439 0.473860432056872 no 1570 0.475180940047841 2294 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_1381 2324-0066 62.1 µM 0.0621955532601915 0.47388496257097 no 1571 0.475203551810245 2235 10885928 SGTC_2822 7994718 71.43 µM 0.0617327147559637 0.474084893061426 no 1572 0.475387843518139 2300 1018011 SGTC_2897 9048598 12.99 µM 0.0601182998407491 0.474782316155726 no 1573 0.476030707579201 2273 6467404 SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.0597698552911704 0.474932853518957 no 1574 0.476169467315459 2234 75037 A free radical scavenger. SGTC_276 colchicine 750 µM 0.0564549079568926 0.476365175344666 no 1575 0.477489708218749 2218 2833 A microtubule depolymerizer. SGTC_747 3448-8087 38.7 µM 0.056409506525019 0.476384794549316 no 1576 0.477507791951901 2257 5168703 SGTC_3212 9128307 49.47 µM 0.0561815687762806 0.476483293569976 no 1577 0.477598581977622 2084 27243542 SGTC_3302 9125395 16.351 µM 0.0556928394228252 0.476694493624383 no 1578 0.477793251981712 2222 17599668 SGTC_1140 3229-1848 2.98 µM 0.0555424094644987 0.476759501916773 no 1579 0.477853172104503 2283 2849525 SGTC_1387 3342-1166 1.8 µM 0.0550429178665556 0.476975361590933 no 1580 0.47805213604288 2234 3418228 SGTC_517 1365-0151 113 µM 0.0545142443352078 0.47720383985185 no 1581 0.478262730063473 2212 768657 SGTC_330 1488-0319 80.1 µM 0.0533354954277973 0.477713289805038 no 1582 0.478732299588268 2203 6846614 SGTC_772 k072-0172 35.3 µM 0.0529131625107571 0.477895829089868 no 1583 0.478900548460938 2206 5861980 SGTC_1131 3454-3128 32.3 µM 0.0524122531082193 0.478112336442448 no 1584 0.479100105484414 2232 710982 SGTC_2891 9063876 19.48 µM 0.0519688065530732 0.478304012103574 no 1585 0.479276774289208 2332 6472478 SGTC_2321 7390090 138.78 µM 0.0517506504348095 0.478398309907035 no 1586 0.479363689034098 2242 649046 SGTC_3213 9129884 49.47 µM 0.0510992662351534 0.478679877369081 no 1587 0.479623210345102 2264 17190742 SGTC_2267 7931562 200 µM 0.0507644762587693 0.478824597898851 no 1588 0.479756599099949 2282 934880 SGTC_2977 9011197 71.43 µM 0.0507454053805793 0.478832841800963 no 1589 0.479764197486313 2308 2704722 SGTC_1842 st055362 61.2 µM 0.0506173978545596 0.478888176745181 no 1590 0.479815199556464 2236 676032 SGTC_2063 5246145 200 µM 0.0497834478180306 0.479248685608762 no 1591 0.480147478527069 2280 711240 SGTC_3247 9135149 49.47 µM 0.049366162459582 0.479429080588848 no 1592 0.480313746857135 2324 8934436 YOR116C RPO31 SGTC_2385 9074692 200 µM 0.0488937482035986 0.479633313207749 no 1593 0.480501985558 2226 17046906 SGTC_1031 k035-0009 16 µM 0.0482627246228698 0.479906123634169 no 1594 0.480753430679251 2317 5180959 SGTC_2738 aclarubicin 5.55 µM 0.0459077812451573 0.480924318396573 no 1595 0.481691876090558 2303 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_350 k064-0020 19.8 µM 0.0426039416850204 0.482352990813238 no 1596 0.483008626667375 2334 2790705 SGTC_606 k015-0008 38.6 µM 0.0415847237913713 0.482793775668403 no 1597 0.483414875678054 2320 1970475 SGTC_2763 lisinopril 49.32 µM 0.040854501937027 0.483109590322745 no 1598 0.483705944666976 2344 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_963 1269-2853 151 µM 0.0407859694864644 0.483139230563624 no 1599 0.483733262389949 2296 3668223 SGTC_1444 4112-3581 28 µM 0.0403210479572295 0.483340311278595 no 1600 0.483918586789634 2314 2877249 SGTC_1236 0330-0013 258 µM 0.0402690255546652 0.48336281147322 no 1601 0.483939323883401 2296 4617066 SGTC_3008 9078912 71.4286 µM 0.0397832371940526 0.483572922207547 no 1602 0.484132970216186 2313 16648731 SGTC_582 0987-0078 156 µM 0.0387280411017751 0.484029325942929 no 1603 0.484553608304376 2337 1625765 SGTC_2601 securinine 100 µM 0.0383483893874636 0.484193541766152 no 1604 0.484704954992793 2305 442872 A GABA receptor antagonist. SGTC_536 3852-0578 10.6 µM 0.0382393211341239 0.484240719010482 no 1605 0.484748435038798 2330 2869208 SGTC_1641 st009299 47.1 µM 0.0379579002953649 0.484362448021709 no 1606 0.484860624258483 2345 4046054 SGTC_61 0978-8327 98.565 µM 0.0365148853736506 0.484986648968907 no 1607 0.485435904906457 2344 6150059 YHR072W ERG7 SGTC_1682 st012968 530 nM 0.0359416321769886 0.485234629804347 no 1608 0.485664449810554 2283 24207270 SGTC_338 4055-0136 114 µM 0.0357808391400423 0.485304187518291 no 1609 0.485728555717059 2337 2900563 SGTC_1698 5-fluorocytosine 1.055 µM 0.035430076281199 0.485455926126477 no 1610 0.485868401178583 2341 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1660 st012960 28.1 µM 0.0345371221892035 0.485842223944786 no 1611 0.4862244203844 2293 24207266 SGTC_1569 carminic acid 40.6 µM 0.0344574294649786 0.485876700193009 no 1612 0.486256194269452 2336 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_1330 1469-0054 61.8 µM 0.034147836243426 0.486010635787443 no 1613 0.486379631450942 2354 7102664 SGTC_1922 5578187 25 µM 0.033453362191074 0.486311083467392 no 1614 0.4866565282877 2348 1350412 SGTC_2697 mebhydrolin 72.4 µM 0.0324433986798801 0.486748033978441 no 1615 0.487059226773651 2331 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_2884 9058502 51.95 µM 0.0314309503275503 0.487186075498869 no 1616 0.487462929273509 2311 6471554 SGTC_1651 st011928 86.1 µM 0.030950562906296 0.487393923280909 no 1617 0.487654482924555 2334 720198 SGTC_3187 9109394 49.47 µM 0.0308462083398009 0.487439074512265 no 1618 0.487696094505022 2332 17098090 SGTC_315 k915-0449 187 µM 0.0305449878993257 0.487569404868499 no 1619 0.487816207474258 2294 20970215 YNL149C PGA2 SGTC_2471 5466956 24.79 µM 0.0295039827811856 0.488019831208368 no 1620 0.488231321262833 2276 724419 SGTC_2003 4023581 200 µM 0.0292411638957486 0.488133551194201 no 1621 0.488336125608395 2312 16641307 SGTC_258 haloperidol 50.781 µM 0.0290637384985463 0.488210322531014 no 1622 0.488406878029457 2334 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_291 SEC14.278 35.5 µM 0.0288643108890083 0.488296614667993 no 1623 0.488486404769575 2350 1068044 SGTC_1678 st019265 80.2 µM 0.0283838146900808 0.488504527158773 no 1624 0.488678016503687 2361 5367020 SGTC_2012 4023501 200 µM 0.027289683818195 0.48897797321915 no 1625 0.489114342463131 2329 3477460 SGTC_888 0916-0002 6.97 µM 0.0261682698189229 0.489463241190221 no 1626 0.48956156211391 2346 2802138 YIL048W NEO1 SGTC_597 k018-0003 82.8 µM 0.0257077980262319 0.48966250508771 no 1627 0.489745201994167 2348 6786234 SGTC_1654 st012436 41.8 µM 0.0251954808538089 0.48988420750995 no 1628 0.489949520784849 2360 4323132 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.0246875302078696 0.490104023427809 no 1629 0.490152100751553 2306 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2498 4'-Methoxychalcone 54.63 µM 0.0246347348056808 0.490126870840356 no 1630 0.490173156665918 2353 641818 YHR062C RPP1 SGTC_154 3389-1638 511.116 µM 0.0238354849501713 0.490472753191366 no 1631 0.490491917593048 2279 5238686 SGTC_3236 9132701 49.47 µM 0.0238043532211208 0.490486225865488 no 1632 0.490504333833112 2351 24282524 SGTC_2792 7535235 81.82 µM 0.0237770615345912 0.490498036718533 no 1633 0.49051521855997 2322 1281891 SGTC_533 1222-0222 6.71 µM 0.0234199708483132 0.490652573392572 no 1634 0.490657637470555 2352 3982874 SGTC_2128 5255449 168.493 µM 0.0233326333317742 0.49069037030641 no 1635 0.490692470579954 2366 736008 SGTC_991 3996-0057 64.7 µM 0.0230457634451981 0.490814519103297 no 1636 0.490806884339789 2350 715343 SGTC_1009 4106-0057 9.87 µM 0.0228956273473929 0.490879493918582 no 1637 0.490866764176994 2378 2928005 SGTC_1741 st038134 10.228 µM 0.0226224346520713 0.490997724898382 no 1638 0.490975724070693 2345 1272587 SGTC_2658 polymyxin b sulfate 77.05 µM 0.0221745227973206 0.491191571676165 no 1639 0.491154370227672 2355 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_223 busulfan 5 mM 0.0218537735867302 0.49133038643188 no 1640 0.491282299646126 2344 2478 A DNA alkylator. SGTC_12 0849-0099 9.267 µM 0.0206044391684797 0.491871086790393 no 1641 0.491780599637212 2375 6071388 SGTC_1082 camptothecin 424.86 nM 0.0197198000376087 0.492253959499513 no 1642 0.492133447852269 2378 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2288 7946289 167.31 µM 0.0190300005053172 0.492552510403493 no 1643 0.492408586398717 2367 1246052 SGTC_1297 1068-0111 14.1 µM 0.018588893268372 0.49274342743658 no 1644 0.492584531597255 2360 767057 SGTC_1419 3993-2473 62.6 µM 0.0158346233113119 0.493935547684623 no 1645 0.493683163243646 2374 704026 SGTC_1348 1493-0373 93.8 µM 0.0157805729766898 0.493958942663205 no 1646 0.493704723513483 2351 3010129 SGTC_1921 5740136 50 µM 0.015548085904677 0.494059571879623 no 1647 0.493797461057687 2371 1774243 SGTC_1145 3546-0597 10.2 µM 0.0153855880421151 0.494129907338309 no 1648 0.493862280571842 2316 875334 SGTC_2455 5377712 9.75 µM 0.0145397021882021 0.494496042864689 no 1649 0.494199702420061 2349 2243908 SGTC_1939 st074455 53.6 µM 0.0140135230217153 0.494723798040423 no 1650 0.494409596142684 2384 1644229 SGTC_92 0063-0024 660.874 µM 0.0136993309520655 0.494859796020977 no 1651 0.494534928610388 2377 3594437 SGTC_2317 5986382 200 µM 0.0136207406893461 0.494893813896013 no 1652 0.494566278663964 2371 877883 SGTC_1740 st038286 13.222 µM 0.0124975256566499 0.495380002601507 no 1653 0.49501433839904 2371 716786 SGTC_2570 licareol 100 µM 0.0116216760764453 0.495759122851081 no 1654 0.495363726409322 2363 443158 SGTC_2618 avocadyne 43.43 µM 0.011313108905939 0.495892690166629 no 1655 0.495486818805834 2375 3015189 SGTC_2696 st077691 74.316 µM 0.0110835990457975 0.495992036795936 no 1656 0.495578374251763 2377 757133 SGTC_1919 st067113 52.3 µM 0.0109437927233316 0.496052554086714 no 1657 0.495634145522145 2369 1268243 SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.0106013755966116 0.496200774923281 no 1658 0.495770742264701 2389 16486 A toxic proline analog. SGTC_2857 9024691 58.44 µM 0.0103602173678375 0.496305164510771 no 1659 0.495866945194242 2377 16478292 SGTC_1977 st070720 65.3 µM 0.0101163930172174 0.496410708433248 no 1660 0.49596421193843 2341 682188 SGTC_2889 9059656 51.95 µM 0.00941425010439071 0.496714645479985 no 1661 0.496244313071736 2385 3949838 SGTC_2745 rifampicin 24.3 µM 0.0093183437799259 0.496756160663281 no 1662 0.49628257248127 2384 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_1777 st045864 34.765 µM 0.00856226702853478 0.497083446476877 no 1663 0.496584191403145 2389 4691462 SGTC_1648 st011736 69.8 µM 0.00806476945355498 0.497298801225242 no 1664 0.49678265735959 2390 2855514 SGTC_1980 st071811 45.7 µM 0.00760712141550593 0.497496906762994 no 1665 0.49696522690476 2368 4974850 SGTC_2020 4017018 200 µM 0.00720413885940421 0.497671349356357 no 1666 0.497125989275131 2385 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_554 4483-2211 187 µM 0.00676828208821708 0.497860022999712 no 1667 0.497299866724699 2384 747107 SGTC_2130 NSC 7 2.4545 µM 0.00627259355794098 0.498074597189409 no 1668 0.497497613631552 2385 21448 SGTC_2911 7942208 15.64 µM 0.0059443926065812 0.498216669484264 no 1669 0.497628544424152 2387 1243384 SGTC_2910 7948405 25.97 µM 0.0058615039283167 0.498252550540256 no 1670 0.497661611646353 2386 2971328 SGTC_1814 st052110 31.539 µM 0.0056610606582004 0.498339318976483 no 1671 0.497741575614383 2394 674163 SGTC_237 nikkomycin 200 µM 0.00465942630563311 0.498772910315893 no 1672 0.498141164570235 2393 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_212 3807-4682 38.772 µM 0.00434424405667787 0.498909347946735 no 1673 0.49826690282071 2390 3125501 YBL034C STU1 SGTC_2878 9043973 25.97 µM 0.00333352989379503 0.499346871609756 no 1674 0.498670116445421 2389 6465167 SGTC_1870 st057514 26.5 µM 0.00272136305468903 0.499611870268863 no 1675 0.498914334557202 2401 5393161 SGTC_45 0kpi-0036 14.9 µM 0.00205464388737198 0.499900484076246 no 1676 0.499180316258883 2380 2795021 SGTC_2100 5377183 190 µM 0.0019808982202098 0.499932407594854 no 1677 0.499209736463613 2399 2844202 SGTC_956 1185-0240 191 µM 0.00192388898689512 0.499957086134127 no 1678 0.499232479813806 2398 1416193 SGTC_2812 7970281 58.44 µM 0.00172562064160417 0.499957086134127 no 1679 0.499311577307791 2403 2233435 SGTC_1645 Cervolide 78 µM 0.00166545408197894 0.499931040830272 no 1680 0.499335580257786 2397 23173 A fragrance. SGTC_3205 9113483 49.47 µM 0.00121425941844107 0.499735724675283 no 1681 0.499515580697648 2401 17018033 SGTC_990 3985-0011 41.3 µM 0.000392006638609355 0.499379782604224 no 1682 0.499843611981666 2403 5399565 YGL099W LSG1 SGTC_168 3970-0862 530.542 µM 0.000263847808191766 0.499324304422844 no 1683 0.499894739954942 2398 3135186 SGTC_2795 7780010 54.55 µM 0.000144387127013533 0.499272591561456 no 1684 0.499942397870489 2402 953673 SGTC_627 1391-0720 175 µM 5.00506522761878e-05 0.499231754626933 no 1685 0.499980032678654 2401 997839 SGTC_502 l-744,832 89.3 µM 0 0.499210088405997 no 1686 0.5 2405 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_1443 4112-3303 14 µM 0 0.499210088405997 no 1687 0.5 2405 704433 SGTC_1398 3558-0053 112 µM -0.000385148044835567 0.499043363336229 no 1688 0.4998463481645 2406 4532369 SGTC_230 MPP+ 141.667 µM -0.000572336572764456 0.498962332163274 no 1689 0.49977167075497 2406 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_2044 5102272 200 µM -0.000819296696270042 0.498855426807801 no 1690 0.499673147944231 2409 592666 SGTC_1334 1486-0610 236 µM -0.00292442737865071 0.49794415123927 no 1691 0.498833323935649 2425 3742339 SGTC_3270 9137563 49.47 µM -0.00326964318355212 0.497794714036846 no 1692 0.498695603416378 2432 17015724 SGTC_485 niflumic acid 177 µM -0.00414509035685136 0.497415751431307 no 1693 0.498346352936001 2410 4488 A COX2 inhibitor. SGTC_2303 7774051 200 µM -0.00452496820579707 0.497251311032998 no 1694 0.498194805025567 2422 2953184 SGTC_2555 cholic acid 100 µM -0.00526460576957156 0.496931140279885 no 1695 0.497899735870723 2449 6708657 Influences liver metabolism. SGTC_2314 7727897 200 µM -0.00551683664051033 0.496821956234588 no 1696 0.497799111774222 2422 900724 SGTC_2787 5284540 71.43 µM -0.00657510324402189 0.496363863416919 no 1697 0.497376932218039 2423 736958 SGTC_2352 9027995 87.8 µM -0.00657904083628071 0.49636215895639 no 1698 0.49737536137998 2411 2997347 SGTC_173 1273-0061 2.693 µM -0.0085509556785417 0.495508587694051 no 1699 0.496588703813713 2431 2847414 YPL266W DIM1 SGTC_2348 9022543 33.42 µM -0.00862368096220288 0.495477107894379 no 1700 0.496559691692939 2431 3162678 YDL140C RPO21 SGTC_2856 9022925 19.48 µM -0.00951213070244357 0.495092536686455 no 1701 0.496205266111163 2440 4944862 SGTC_210 3551-0445 56.827 µM -0.00972132845365665 0.495001984738903 no 1702 0.496121812142454 2414 2865180 YOR207C RET1 SGTC_712 r015-0009 80.6 µM -0.0101658471851197 0.494809574177364 no 1703 0.495944483594394 2424 6813872 YLR060W FRS1 SGTC_2271 7849410 118.62 µM -0.0102917926234725 0.494755058733848 no 1704 0.49589424126251 2418 972430 SGTC_2725 haloperidol 53.21 µM -0.010775462419342 0.49454570333363 no 1705 0.495701295637726 2420 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2099 5377090 177.372 µM -0.0111094760307854 0.494401127154925 no 1706 0.49556805146392 2440 2243829 SGTC_418 lividomycin a 100 µM -0.0119475118905787 0.494038390659343 no 1707 0.495233745753123 2421 72394 An antibiotic. SGTC_2566 crystal violet carbinol 226 nM -0.0132349263037613 0.493481154292752 no 1708 0.494720182458237 2474 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_452 diindolylmethane 8 µM -0.0136453623481371 0.493303506356006 no 1709 0.494556456956033 2443 3071 Inhibits expression of several cancer promoting factors. SGTC_489 paxilline 115 µM -0.0141188381230894 0.49309857475303 no 1710 0.49436758565225 2453 105008 A toxic potassium channel blocker. SGTC_1771 st048882 4.1505 µM -0.0141801164614802 0.493072052159286 no 1711 0.494343141579265 2430 4580403 SGTC_2974 9094440 9.66 µM -0.0144312346643013 0.492963363076519 no 1712 0.494242970161727 2551 25236134 SGTC_838 0109-0203 71.4 µM -0.0146138690956655 0.492884315495258 no 1713 0.494170117248209 2428 759422 SGTC_3284 9108171 64.8615 µM -0.0146583924091906 0.492865045018698 no 1714 0.49415235691836 2446 8687505 SGTC_3281 9140613 49.47 µM -0.0153670877176723 0.492558311442732 no 1715 0.493869660261016 2443 16013766 SGTC_3310 9130229 44.1445 µM -0.0155357534951414 0.492485311097079 no 1716 0.4938023803831 2483 7761258 SGTC_2572 astragaloside iv 100 µM -0.015604631335842 0.492455500105954 no 1717 0.493774905430857 2496 45006101 An anti-inflammatory agent. SGTC_2167 5876490 200 µM -0.0161337292446789 0.492226502865691 no 1718 0.49356385248351 2471 686534 SGTC_775 4577-0580 57.3 µM -0.0179123442576271 0.491456725183378 no 1719 0.492854390650503 2536 2006902 SGTC_2349 9023730 187.07 µM -0.0207415365890503 0.490232328429083 no 1720 0.491725917365751 2449 4126287 SGTC_1133 3473-0247 50 µM -0.021068046619315 0.490091029558479 no 1721 0.49159568716936 2484 711311 SGTC_1916 st067606 49.2 µM -0.0211463167787664 0.490057157934354 no 1722 0.491564468848329 2467 19590279 SGTC_979 1426-2828 121 µM -0.0220929088997014 0.489647523371445 no 1723 0.491186921487661 2493 747872 SGTC_645 0845-0943 5.41 µM -0.0221442700221104 0.489625297326545 no 1724 0.491166436375965 2458 1885106 SGTC_1214 0358-0031 63.7 µM -0.0238208320168465 0.488899798907852 no 1725 0.490497761608386 2491 4301366 SGTC_2443 5493264 126.67 µM -0.0241701698346303 0.488748634550642 no 1726 0.490358436099916 2471 5340055 SGTC_2075 5212009 200 µM -0.0246608267143903 0.488536321789444 no 1727 0.49016275066173 2457 780898 SGTC_248 streptozotocin 5.23457 mM -0.0260320850827706 0.487942980257069 no 1728 0.489615873460946 2488 5300 DNA alkylating agent. SGTC_2335 9018011 154.17 µM -0.0265687769073549 0.487710761666654 no 1729 0.489401838441312 2490 6458208 SGTC_3346 9158254 43.5805 µM -0.0277075336964159 0.487218052394483 no 1730 0.488947707495443 2475 17639500 SGTC_378 3970-0959 8.33 µM -0.0277735503654672 0.487189489357831 no 1731 0.488921380786599 2494 6615653 SGTC_148 3253-0744 288.01 µM -0.0280546433498514 0.487067871277845 no 1732 0.488809284591779 2452 6893655 SGTC_34 0469-0683 81.75 µM -0.0289467471317277 0.4866819004394 no 1733 0.488453531203214 2481 3690923 SGTC_1908 st060353 56.5 µM -0.0292919859051026 0.486532535385224 no 1734 0.48831585924135 2468 4227716 SGTC_611 3453-1652 23.7 µM -0.03008694486502 0.486188609368591 no 1735 0.487998856253608 2461 1560575 SGTC_288 1315-0019 35.1 µM -0.03061559443569 0.485959903433107 no 1736 0.487788052709237 2486 6811474 SGTC_2719 novobiocin 32.65 µM -0.031731311450735 0.485477233898745 no 1737 0.487343162263308 2466 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_1534 6-azauridine 81.6 µM -0.0326325114490944 0.485087381916765 no 1738 0.486983821621343 2461 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_2409 alverine citrate 63.97 µM -0.0332154757132742 0.484835203761997 no 1739 0.486751378548743 2702 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_3250 9135583 49.47 µM -0.034038362677543 0.484479250408872 no 1740 0.486423279710518 2516 7699353 SGTC_705 1124-0212 310 µM -0.034146475547369 0.484432485313779 no 1741 0.48638017397374 2469 9554485 SGTC_532 1548-0774 215 µM -0.0360184594211835 0.483622778076437 no 1742 0.485633820007099 2575 5932993 SGTC_2186 6124449 200 µM -0.03667040336877 0.48334080215924 no 1743 0.485373903727262 2494 3834182 YLR033W RSC58 SGTC_777 1315-0167 517 µM -0.0367968046725307 0.483286132585476 no 1744 0.485323510913364 2525 4221767 SGTC_2914 7968218 45.32 µM -0.0384168198271863 0.4825854912679 no 1745 0.484677675299084 2496 2977111 SGTC_280 3448-3607 3.04 µM -0.038429535072648 0.482579992253705 no 1746 0.484672606393161 2469 626179 SGTC_629 3448-6466 76.7 µM -0.0385902808551998 0.482510474153985 no 1747 0.484608525638091 2478 573744 SGTC_3324 9138759 60.749 µM -0.0392175658948224 0.482239195850466 no 1748 0.48435846442537 2549 45595710 SGTC_1393 3470-5649 58.2 µM -0.0392621757662668 0.482219903991183 no 1749 0.484340681357695 2526 4108395 SGTC_546 peri-Naphthalide 147 µM -0.039574259480374 0.482084942314655 no 1750 0.48421627465848 2524 223824 A penicillin ester. SGTC_1169 aniline yellow 25.8 µM -0.0398370894426775 0.481971282184605 no 1751 0.484111503294975 2504 6051 A DNA damaging agent. SGTC_3273 9137859 49.47 µM -0.0401701207523513 0.481827265771335 no 1752 0.483978749290317 2473 2377234 SGTC_371 0195-0006 7.36 µM -0.040213182527948 0.481808644264106 no 1753 0.483961583997105 2453 3928593 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.0407719254393596 0.481567026740742 no 1754 0.483738860497582 2523 688751 SGTC_657 3534-0529 86.7 µM -0.0411826969607948 0.4813894008855 no 1755 0.48357512389731 2496 1049549 SGTC_1296 1068-0102 11.9 µM -0.041675594910239 0.481176266793089 no 1756 0.483378654746993 2517 767053 SGTC_2518 prenyletin 46.28 µM -0.0436215957421612 0.480334849357037 no 1757 0.482603018583929 2500 3873459 A coumarin with calcium channel inhibitory activity. SGTC_2015 5119600 184 µM -0.043717783690765 0.480293261576714 no 1758 0.482564681716819 2508 2828786 SGTC_2109 5483026 200 µM -0.0443717068357635 0.480010537354621 no 1759 0.48230405705148 2509 759335 SGTC_877 0771-0151 33.1 µM -0.0455523701495107 0.479500102142103 no 1760 0.481833516423382 2562 6166523 SGTC_1727 st034309 9.9045 µM -0.0458482293726278 0.479372198798864 no 1761 0.481715608860972 2543 870305 SGTC_678 1218-2179 85.9 µM -0.0460610085021003 0.479280213247517 no 1762 0.48163081185559 2491 6820081 YOR116C RPO31 SGTC_1880 MG-132 525 µM -0.0464578109189902 0.479108676400124 no 1763 0.481472679882026 2523 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_2441 5730946 39.09 µM -0.0466123515710035 0.479041869847625 no 1764 0.481411093800826 2549 1774275 SGTC_854 0422-0053 192 µM -0.0475261599682403 0.478646850683437 no 1765 0.481046940624535 2497 3596728 SGTC_2638 epoxomicin 18 µM -0.0483188214355846 0.478304217631982 no 1766 0.480731077368014 2538 9915668 A protesome inhibitor. SGTC_1935 st074532 41.6 µM -0.0484503944695892 0.478247345880998 no 1767 0.480678648727325 2626 2829742 SGTC_2930 9013230 14.89 µM -0.0485739672638874 0.478193932594829 no 1768 0.480629408291109 2514 2995857 SGTC_1363 1636-0063 10.4 µM -0.0487697111191281 0.478109324785211 no 1769 0.480551410232655 2503 6072185 SGTC_2772 vinpocetine 57.06 µM -0.0492310543061602 0.477909918927891 no 1770 0.480367581753262 2527 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_724 3910-0327 137 µM -0.0492630474835425 0.477896090756562 no 1771 0.480354833790136 2523 2885483 SGTC_2174 5790901 200 µM -0.0496471278704363 0.477730084651049 no 1772 0.480201795151539 2527 786020 SGTC_162 k030-0015 37.8 µM -0.0510702047049522 0.477115040436114 no 1773 0.47963478910012 2524 1809920 YMR134W ERG29 SGTC_265 mycophenolic acid 32.932 µM -0.0522536373679176 0.476603610266254 no 1774 0.479163297417169 2565 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_1813 st051246 8.6015 µM -0.0524318778731726 0.47652658548272 no 1775 0.479092287086079 2513 5291959 SGTC_1829 berberine 14.4 µM -0.0527869995144769 0.47637312597017 no 1776 0.478950809971811 2625 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_475 α-linolenic acid 10 µM -0.0552429627982493 0.475311922181317 no 1777 0.477972450904971 2616 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_920 mycophenolic acid 780.421 nM -0.0563707100261166 0.474824689055776 no 1778 0.477523244927075 2525 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2243 6634756 200 µM -0.0568323621678485 0.474625247186899 no 1779 0.477339367154295 2607 885676 SGTC_2944 9067346 25.62 µM -0.0573290264715249 0.474410686548292 no 1780 0.477141549294702 2539 6473075 SGTC_995 3931-2021 34.6 µM -0.0574805948808508 0.474345209964278 no 1781 0.477081181794776 2565 730143 SGTC_1764 st044502 93.5 µM -0.0574870541278093 0.474342419626262 no 1782 0.477078609182036 2563 8407 SGTC_2671 danthron 100 µM -0.0585947967547809 0.47386390326216 no 1783 0.476637427576099 2539 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_1742 st038235 28.8875 µM -0.0587331940942424 0.473804121801725 no 1784 0.476582309950256 2593 564103 YBR002C RER2 SGTC_1762 st045503 25.4615 µM -0.0597117517855131 0.473381445557066 no 1785 0.476192605933197 2557 4645554 SGTC_3000 9075062 71.4286 µM -0.0604770272800512 0.473050914853687 no 1786 0.475887855964016 2541 17057871 SGTC_3280 9140961 49.47 µM -0.0605114208218013 0.473036060347682 no 1787 0.475874160009505 2518 4901226 SGTC_2389 9091542 195.52 µM -0.0619154287906387 0.472429704188292 no 1788 0.475315090336711 2563 3626624 YOL127W RPL25 SGTC_980 1473-0395 201 µM -0.0635251613822545 0.471734579374889 no 1789 0.474674161908927 2513 768876 SGTC_702 1488-0190 94 µM -0.0652776851628892 0.470977891532438 no 1790 0.473976454551562 2528 949357 SGTC_2444 5485484 36.41 µM -0.0653790779431246 0.470934116313921 no 1791 0.473936090908506 2585 6790631 SGTC_2970 9090938 41.86 µM -0.0661351505382837 0.470607701389966 no 1792 0.473635113008256 2539 17217104 SGTC_197 4544-0043 41.561 µM -0.0669963722016415 0.470235915126198 no 1793 0.473292295638471 2528 896523 SGTC_1861 st057647 17.4 µM -0.0677168551903917 0.469924905154684 no 1794 0.473005515804203 2640 688668 SGTC_2440 5628896 157.78 µM -0.0688970690893422 0.46941548345711 no 1795 0.472535775752685 2549 5522048 SGTC_1995 st072814 61.1 µM -0.0696090488803011 0.469108192173114 no 1796 0.472252417224404 2542 5769371 SGTC_99 0109-0120 622.8 µM -0.0701793908453812 0.4688620452005 no 1797 0.472025438798703 2533 759414 SGTC_104 0074-0074 590.992 µM -0.0705373974726152 0.468707543535625 no 1798 0.471882967893091 2519 3943124 SGTC_2512 diallyl trisulfide 49.23 µM -0.0710187978338673 0.468499797392032 no 1799 0.471691397378471 2503 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_2534 helenine 20.12 µM -0.0714520965785877 0.468312816615931 no 1800 0.471518974225659 2545 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_1625 st003711 30.1 µM -0.0736090540741963 0.467382132704417 no 1801 0.470660733288462 2595 24207034 YER133W GLC7 SGTC_1683 st010134 710 nM -0.0736189925355269 0.467377844866346 no 1802 0.470656779144365 2532 3818134 SGTC_1092 toremifene 6.32 µM -0.0739692093288239 0.467226750165353 no 1803 0.470517442758854 2528 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.0745161780092586 0.466990779876249 no 1804 0.470299834382302 2619 6708739 YPR165W RHO1 SGTC_1172 0370-0043 85 µM -0.0760259640660313 0.46633949654521 no 1805 0.469699220817446 2636 376585 SGTC_3307 9126885 69.2785 µM -0.0761503186801366 0.466285857119038 no 1806 0.469649753903603 2539 24824909 SGTC_1687 st020778 55.3625 µM -0.0763583291059625 0.466196134757958 no 1807 0.469567010664631 2552 4259299 SGTC_300 r073-0011 5.04 µM -0.0772971696003969 0.465791200604439 no 1808 0.46919357125207 2537 2735780 SGTC_1385 3091-4834 14.1 µM -0.0775560781740752 0.465679536171033 no 1809 0.469090590816427 2608 4072814 SGTC_1723 st034307 2.5525 µM -0.0783747614958144 0.465326464839092 no 1810 0.468764974586132 2596 867466 SGTC_2200 6600604 21.907 µM -0.0784375691315903 0.46529937908441 no 1811 0.468739994864572 2543 2904777 SGTC_1225 1216-0074 20.6 µM -0.0799840986263218 0.464632490207371 no 1812 0.46812495145282 2575 4241466 SGTC_2525 harmine 47.85 µM -0.0810205961211115 0.464185590975174 no 1813 0.467712786506968 2612 5280953 A monoamine oxidase inhibitor SGTC_2401 5128683 200 µM -0.0821711854380362 0.463689552524059 no 1814 0.467255293313515 2576 708373 SGTC_2701 st077767 14.721 µM -0.0832782845661205 0.463212316699012 no 1815 0.466815133356076 2573 5721188 SGTC_3024 9090631 49.47 µM -0.0833909322606877 0.463163760755184 no 1816 0.466770349203531 2544 25236383 SGTC_602 3130-1533 38.1 µM -0.0841211257773983 0.462849029656703 no 1817 0.466480064116468 2637 720941 SGTC_3327 9140648 26.9345 µM -0.0843785213260722 0.462738091471916 no 1818 0.466377741937848 2574 8029710 SGTC_2918 7977171 22.06 µM -0.0849221870060398 0.462503779614427 no 1819 0.466161626410747 2544 2236483 SGTC_395 anisomycin 6.25 µM -0.086014011872824 0.462033258647602 no 1820 0.465727639321874 2595 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_792 4534-1957 155 µM -0.0861114085446899 0.461991288208833 no 1821 0.465688927303208 2618 1717904 SGTC_90 0870-0863 4.608 µM -0.0886531171802897 0.460896159222738 no 1822 0.464678796413934 2558 1738164 SGTC_634 1611-4317 11.2 µM -0.089952285885633 0.460336509083091 no 1823 0.464162565696552 2554 2843522 SGTC_2151 5563267 85.4165 µM -0.0900045508153571 0.460313996264659 no 1824 0.464141799240499 2610 5310824 SGTC_2301 7769476 200 µM -0.0921194732668339 0.459403113081816 no 1825 0.463301558403219 2628 977820 SGTC_1503 4585-0012 61.3 µM -0.0924782524921308 0.459248610237874 no 1826 0.463159034582392 2756 2922052 SGTC_1291 0993-0025 5.79 µM -0.092620872094528 0.459187194972652 no 1827 0.46310238074533 2646 4353356 SGTC_2885 9057732 51.95 µM -0.0927480138154677 0.459132445658602 no 1828 0.463051875932246 2670 6471414 SGTC_2543 pimpinellin 60.67 µM -0.0928166621046611 0.459102884899512 no 1829 0.463024606853961 2567 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_2764 methyldopa 94.69 µM -0.0935496546949304 0.458787263816776 no 1830 0.462733451936723 2635 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_1347 1493-0251 600 nM -0.0937215231525868 0.458713262307204 no 1831 0.46266518626316 2640 3986378 SGTC_734 2023-0417 80 µM -0.0943429053297125 0.458445725349846 no 1832 0.462418384178949 2665 3935732 SGTC_2177 5811945 192 µM -0.0944900814009718 0.458382361241045 no 1833 0.462359930544733 2679 5343475 SGTC_2442 5158906 48.48 µM -0.0947872670558233 0.458254416329161 no 1834 0.462241900374958 2685 1893835 SGTC_3190 9110366 49.47 µM -0.0954555793612348 0.457966709112315 no 1835 0.461976485811734 2588 17123768 SGTC_1892 st058411 7.36 µM -0.0954929868573094 0.457950605903578 no 1836 0.461961630241253 2658 3934738 SGTC_1879 gemcitabine 100 µM -0.0956554570560484 0.457880666404125 no 1837 0.46189710936448 2579 60750 A nucleoside analog which inhibits DNA replication. SGTC_3131 9127911 49.47 µM -0.095806472198074 0.457815659199574 no 1838 0.461837138469122 2766 45595681 SGTC_725 1497-0963 19 µM -0.0963021004759157 0.457602314964417 no 1839 0.461640321452075 2612 3549977 SGTC_2965 9082772 38.63 µM -0.0963414739127964 0.457585367108645 no 1840 0.461624686421891 2622 16459634 SGTC_1557 sumaresinolic acid 42.3 µM -0.0972816434439124 0.457180704621571 no 1841 0.461251366630233 2557 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_64 000l-0018 272.079 µM -0.0983832177408129 0.456706627710225 no 1842 0.460814000164028 2600 6811119 SGTC_2756 carbadox 75.1 µM -0.0988603182920124 0.456501320327499 no 1843 0.460624587962881 2617 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_1621 st003705 32.4 µM -0.100857527598912 0.455642001721157 no 1844 0.459831779594374 2608 24207032 SGTC_2994 9053520 71.4286 µM -0.101052300664049 0.455558209766276 no 1845 0.459754471347986 2655 4647384 SGTC_2720 fluspirilene 36.88 µM -0.101231319237646 0.455481197184127 no 1846 0.459683417629015 2659 3396 An atypical antipsychotic. SGTC_3065 9113888 49.47 µM -0.10227652829842 0.455031588788914 no 1847 0.45926859265007 2711 16648368 SGTC_1486 3970-0793 4.53 µM -0.103070533317458 0.45469007709371 no 1848 0.458953495723064 2679 2844330 SGTC_1226 3909-7979 35.4 µM -0.104365296393682 0.454133254906433 no 1849 0.458439730858198 2699 6615510 SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.104907618800177 0.45390005196974 no 1850 0.458224556701568 2794 804 An inhibitor of viral and cellular DNA polymerases. SGTC_2569 tetrandrine 100 µM -0.104914324155964 0.453897168712864 no 1851 0.458221896332424 2651 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1072 oxiconazole 14.9 nM -0.105293041697631 0.453734326722858 no 1852 0.458071642102832 2593 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_1054 3429-0080 167 µM -0.105401753936602 0.45368758377673 no 1853 0.458028512189076 2651 1162877 SGTC_1454 4239-0054 42.6 µM -0.10623369782982 0.453329894571243 no 1854 0.457698467606109 2771 1340767 SGTC_1074 carmofur 3.8 µM -0.106246462338141 0.453324406842853 no 1855 0.457693403961403 2583 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1153 4055-0057 267 µM -0.106835476953796 0.453071186885258 no 1856 0.45745975099591 2591 882706 SGTC_1826 st055655 41.6 µM -0.106941207233327 0.453025734993024 no 1857 0.457417810987498 2636 676168 SGTC_1697 st025554 27.742 µM -0.107127011530117 0.452945861949781 no 1858 0.457344109184192 2588 1269519 SGTC_1164 k060-0068 93.7 µM -0.107253632802009 0.452891431434071 no 1859 0.457293883973605 2601 5963676 SGTC_1844 rapamycin 4 nM -0.107413194397886 0.45282284216625 no 1860 0.457230593725201 2592 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_1720 st037298 9.481 µM -0.108382577009474 0.452406172952793 no 1861 0.456846110624282 2673 597396 SGTC_1433 4060-0023 7.6 µM -0.108524860169773 0.452345019857319 no 1862 0.456789680703955 2697 3840627 SGTC_2782 7736369 71.43 µM -0.110777659379881 0.451376921629298 no 1863 0.455896330764303 2644 2950836 YOL077C BRX1 SGTC_2224 6650123 117.647 µM -0.111557586893152 0.451041829482029 no 1864 0.455587101392465 2592 2908370 SGTC_2953 9074162 66.49 µM -0.112752318773112 0.450528586346439 no 1865 0.455113460647504 2650 16451992 SGTC_1810 st050138 53 µM -0.11357378301815 0.450175742649763 no 1866 0.454787835484359 2591 3444541 SGTC_2708 st078559 56 µM -0.113784790408652 0.450085114950194 no 1867 0.454704197888202 2611 17250902 SGTC_468 gf-109203x 121 µM -0.113787133871599 0.450084108447184 no 1868 0.454703269014434 2650 2396 A protein kinase C inhibitor. SGTC_1034 k072-0165 12.7 µM -0.114996577295698 0.449564702878242 no 1869 0.454223917484589 2655 5835461 SGTC_1796 st049173 110.4 µM -0.117387812155088 0.448538022240966 no 1870 0.453276370894101 2595 94134 SGTC_180 1486-1293 102.781 µM -0.117404282263043 0.44853095195981 no 1871 0.453269845393638 2632 4140536 SGTC_3194 9111903 49.47 µM -0.118052362208172 0.448252757467602 no 1872 0.453013084434632 2749 17087251 SGTC_1173 0443-0020 122 µM -0.119503330883671 0.447630007799746 no 1873 0.45243830064254 2646 5331295 SGTC_2686 alizarin 95.37 µM -0.119701963491321 0.447544765527802 no 1874 0.452359622452101 2675 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_2863 9028737 58.44 µM -0.120002197302676 0.447415926165307 no 1875 0.452240703671421 2746 6460917 SGTC_2285 7945142 200 µM -0.120842464600492 0.447055371721026 no 1876 0.45190790732792 2709 2970608 SGTC_1367 1812-0510 76.9 µM -0.12115342891473 0.446921949584577 no 1877 0.451784755327076 2669 1142582 YDR527W RBA50 SGTC_426 0988-0037 14.6 µM -0.121823609178859 0.446634422942185 no 1878 0.451519357895216 2592 5383008 SGTC_1836 st055642 81 µM -0.122268957500033 0.446443371186207 no 1879 0.451343007917343 2641 8571 SGTC_1289 0976-0073 69.1 µM -0.122410057231711 0.446382842839608 no 1880 0.451287136946192 2740 3391136 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.122702720924051 0.446257301231584 no 1881 0.451171254582425 2739 5393153 SGTC_79 0052-0007 94.094 µM -0.123660310249299 0.445846569496839 no 1882 0.450792119108176 2717 2801472 SGTC_2664 lyso-paf C-16 73.48 µM -0.12380688464292 0.44578370553894 no 1883 0.450734090300564 2629 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_3228 9131799 49.47 µM -0.125285719288014 0.445149528026363 no 1884 0.45014867872897 2674 17015818 SGTC_1159 4092-0538 61.2 µM -0.12622035512926 0.444748794820991 no 1885 0.449778749580525 2635 717301 SGTC_3219 9131112 49.47 µM -0.127861672981111 0.444045202473251 no 1886 0.449129221276676 2641 17612988 YMR079W SEC14 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.128485469554749 0.443777842437904 no 1887 0.448882398264449 2611 1241132 A phosphatase inhibitor. SGTC_2066 5222451 176 µM -0.129032629063655 0.443543350210803 no 1888 0.448665915188159 2631 2281147 SGTC_1852 st056254 31.4 µM -0.129086635110782 0.443520206296977 no 1889 0.448644548580865 2676 442583 SGTC_1132 3456-3614 2.5 µM -0.129366410314408 0.44340031367588 no 1890 0.448533862493507 2883 3125502 SGTC_1904 st060225 78 µM -0.129428171760046 0.443373847619228 no 1891 0.448509428656116 2623 66595 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.130146367662561 0.443066104401091 no 1892 0.448225312983114 2718 5379071 SGTC_2642 cholecalciferol 100 µM -0.130435396463563 0.442942266740034 no 1893 0.448110981731944 2699 9821465 A vitamin D precursor, similar to steriods. SGTC_545 4218-0007 221 µM -0.13076553563927 0.442800821693556 no 1894 0.44798039370549 2721 2840508 SGTC_2417 cerulenin 830 nM -0.132216164856331 0.442179399780013 no 1895 0.447406657830183 2616 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_2786 7743617 45.45 µM -0.132758747653987 0.441947004122171 no 1896 0.447192090048303 2680 583674 SGTC_1461 k072-0203 53.8 µM -0.13364839006095 0.44156600134497 no 1897 0.446840308834351 2626 5418714 SGTC_845 0330-0138 4.51 µM -0.135298146756259 0.440859611504265 no 1898 0.446188075140332 2645 9039800 SGTC_1368 1852-0141 284 µM -0.135773176231876 0.440656249027119 no 1899 0.446000298465697 2763 2838987 SGTC_1426 4048-4480 71.7 µM -0.135806910295563 0.440641807901488 no 1900 0.44598696402629 2715 14224343 SGTC_1276 0871-0068 94.2 µM -0.137364806866312 0.439974978417031 no 1901 0.445371223680874 2750 3414906 SGTC_1944 st076371 56.9 µM -0.137475438220746 0.439927631115817 no 1902 0.445327502928847 2651 24208455 SGTC_71 0417-1750 47.813 µM -0.139025995995862 0.439264123996856 no 1903 0.444714803346398 2763 6811472 SGTC_1689 st020265 53.493 µM -0.13946999151026 0.439074162940308 no 1904 0.444539383729162 2750 5758320 YPR016C TIF6 SGTC_128 0906-2981 13.371 µM -0.140595820975153 0.438592545945039 no 1905 0.444094624911395 2761 6740226 SGTC_2845 9003024 42.97 µM -0.140774934428247 0.438515931618617 no 1906 0.444023872635866 2878 2990173 SGTC_3111 9122088 49.47 µM -0.140780441610357 0.438513576002643 no 1907 0.444021697251505 2732 16876704 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.141710521636664 0.438115779293743 no 1908 0.443654331878099 2639 66535 A nucleotide analog. SGTC_1279 0874-0590 65.2 µM -0.142947971143087 0.437586617165607 no 1909 0.443165636040076 2724 3523074 SGTC_1634 st006576 41 µM -0.143111158560665 0.437516842747825 no 1910 0.44310119619985 2745 3915356 SGTC_2346 9031566 143.75 µM -0.143179493985566 0.437487624990798 no 1911 0.443074212189732 2774 4771086 SGTC_2043 5101342 149 µM -0.144514081336821 0.436917072222634 no 1912 0.442547268934414 2686 678451 SGTC_2602 kawain 100 µM -0.146071652426239 0.436251357094865 no 1913 0.441932412222337 2603 5369129 SGTC_662 k832-1615 104 µM -0.147218471044198 0.435761315306011 no 1914 0.441479790831281 2736 5878478 SGTC_367 0335-0881 7.1 µM -0.147340040967768 0.435709373588966 no 1915 0.441431814611042 2800 23828853 SGTC_2723 salbutamol 83.58 µM -0.148573068906142 0.435182615410204 no 1916 0.44094526250707 2768 9884233 β2-adrenoceptor agonist SGTC_3053 9095903 49.47 µM -0.148620406828821 0.435162394604248 no 1917 0.44092658476234 2671 17174018 SGTC_1579 chlormadinone acetate 49.4 µM -0.148828037991607 0.435073705148252 no 1918 0.440844662951367 2817 45114258 A steroidal progestin. SGTC_262 fenpropimorph 62.5 µM -0.149318091412127 0.434864392250618 no 1919 0.440651320210309 2671 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2139 5578692 56.4705 µM -0.149579218633289 0.434752866360305 no 1920 0.440548302415366 2702 650991 YMR113W FOL3 SGTC_3319 9138450 16.7555 µM -0.15041122263814 0.434397557039119 no 1921 0.440220093806183 2699 2029690 SGTC_810 3825-7150 143 µM -0.150592968339932 0.434319949139273 no 1922 0.440148404291929 2756 22330411 YGL099W LSG1 SGTC_2329 6138490 200 µM -0.150711107659438 0.434269503391661 no 1923 0.440101805340015 2949 720019 SGTC_2979 9012552 45.46 µM -0.151812470549608 0.433799270638424 no 1924 0.439667423033939 2752 17100905 SGTC_449 xestospongin c 11.1929 µM -0.152106246096158 0.433673857402685 no 1925 0.439551568930718 2788 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_897 1000-0139 31.4 µM -0.153284144563699 0.43317107790715 no 1926 0.439087101857633 2809 6151020 SGTC_2002 4023503 131 µM -0.153666777583303 0.433007776335204 no 1927 0.438936240619924 2701 4736863 YCR052W RSC6 SGTC_1071 trifluoperazine 6.31 µM -0.154426769296449 0.432683458139115 no 1928 0.438636623986593 2811 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_525 k781-2675 26.7 µM -0.154523791953868 0.432642058034773 no 1929 0.438598376620671 2668 3651118 YDL195W SEC31 SGTC_1067 clotrimazole 1.36 µM -0.154808478895932 0.432520584812198 no 1930 0.438486153304063 2690 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_2376 9072922 81.32 µM -0.1548464113335 0.432504399881499 no 1931 0.438471200747146 2807 17087968 SGTC_306 1672-3436 11.6 µM -0.155194168667975 0.432356024813366 no 1932 0.438334122660561 2777 6797378 SGTC_559 1550-0661 158 µM -0.160405219110931 0.430133818057892 no 1933 0.436280939299459 2764 5830875 SGTC_1101 ebselen 5.29 µM -0.160957037753148 0.429898628088445 no 1934 0.436063619133031 2732 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_2470 5664817 21.68 µM -0.161006390036784 0.429877594920662 no 1935 0.436044183892319 2683 2859561 SGTC_1835 st008666 49.2 µM -0.161376548826803 0.429719845408922 no 1936 0.435898417951224 2706 690455 SGTC_1154 4088-0362 150 µM -0.16192919483696 0.429484346729213 no 1937 0.435680806029858 2690 6618304 SGTC_2019 4016004 108 µM -0.162126730710448 0.429400176980752 no 1938 0.435603028300076 2766 45595336 SGTC_1069 diphenylcyclopropenone 8.49 µM -0.163408520869801 0.428854086206457 no 1939 0.435098397187614 2702 65057 A dermal irritant. YDR527W RBA50 SGTC_135 0933-0004 26.348 µM -0.163756819574188 0.428705721353583 no 1940 0.434961292843141 2795 21230617 YGL099W LSG1 SGTC_1438 4092-1045 4 µM -0.164181306653522 0.428524916149561 no 1941 0.434794208271612 2690 1351342 SGTC_2260 7964312 200 µM -0.164758070606948 0.428279274473614 no 1942 0.434567203870823 2901 231951 SGTC_2946 9065502 71.43 µM -0.164927192889053 0.428207251171316 no 1943 0.434500644327521 2677 16489101 SGTC_2461 5755302 26.15 µM -0.166945581004218 0.427347875061513 no 1944 0.433706433963275 2867 2788904 SGTC_3180 9109287 49.47 µM -0.167800328406624 0.42698404993161 no 1945 0.433370182065874 2832 18891271 SGTC_521 r062-0005 13.8 µM -0.168139708400727 0.426839609290996 no 1946 0.433236685613333 2674 2832033 SGTC_2296 7971656 126.45 µM -0.168913554707472 0.426510295843006 no 1947 0.432932318642725 2773 666570 SGTC_3287 9117173 37.0625 µM -0.168963193681123 0.426489173521536 no 1948 0.432912796142388 2708 2789709 SGTC_3022 9087993 49.47 µM -0.169446837206344 0.426283385104235 no 1949 0.432722592670102 2714 17173644 SGTC_3350 9150499 3.57 µM -0.169532492128967 0.426246941362011 no 1950 0.432688908608024 2696 4910996 YPR165W RHO1 SGTC_2751 anetholtrithion 17.25 µM -0.170062258234414 0.426021554902148 no 1951 0.432480587332941 2838 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_1676 st018489 23.4 µM -0.170391067551082 0.425881676696931 no 1952 0.432351298243279 2767 3696235 SGTC_1759 st043059 70 µM -0.1707857055259 0.425713806750252 no 1953 0.432196134636651 2717 669426 SGTC_152 4469-0003 551.229 µM -0.171395206831342 0.42545456533342 no 1954 0.431956511704833 2713 697280 SGTC_1023 4482-3888 16 µM -0.171854310856148 0.425259314213279 no 1955 0.431776033369034 2917 3303168 SGTC_1404 3909-7820 48.3 µM -0.171888400343124 0.425244817117208 no 1956 0.431762633021765 2754 23741373 SGTC_866 0495-0101 262 µM -0.172561887058771 0.424958426938057 no 1957 0.431497906057927 2720 635694 SGTC_295 k015-0027 31 µM -0.173132272468296 0.424715910016413 no 1958 0.431273729109902 2810 3887424 SGTC_539 4859-0462 2.54 µM -0.17371289827394 0.424469068340914 no 1959 0.431045550145253 2892 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_814 3342-0569 96 µM -0.174147562701463 0.424284298664848 no 1960 0.430874747306932 2705 4346283 SGTC_431 k089-0097 107 µM -0.174490044725404 0.424138726137963 no 1961 0.430740176956899 2752 5499420 SGTC_2004 4023728 41.89 µM -0.174494549568255 0.424136811416291 no 1962 0.430738406937169 2804 360084 YDR527W RBA50 SGTC_1353 1498-1206 8.11 µM -0.175850670368833 0.423560492475772 no 1963 0.430205630325427 2716 6756808 SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.17600304814815 0.423495745754214 no 1964 0.430145773877346 2858 5377381 SGTC_2360 9040895 200 µM -0.176211992201511 0.423406966860521 no 1965 0.430063699894973 2778 4914414 SGTC_3130 9127414 49.47 µM -0.176490330477732 0.42328870887867 no 1966 0.429954372304462 2698 1494646 SGTC_1370 2001-0092 44.6 µM -0.177532131286086 0.422846138901025 no 1967 0.429545214473536 2859 790957 SGTC_2816 7982706 58.44 µM -0.177592374996296 0.422820549593961 no 1968 0.429521556612225 2829 2981853 SGTC_27 0485-0001 32.618 µM -0.177909545009711 0.422685832838498 no 1969 0.429397007301088 2688 2054479 SGTC_3143 9086658 49.47 µM -0.180149802497977 0.421734550365184 no 1970 0.42851748269539 2810 25236626 SGTC_3071 9117417 49.47 µM -0.180403688379319 0.421626771282196 no 1971 0.428417829462187 2814 45595590 YGL055W OLE1 SGTC_853 0419-0306 21 µM -0.180784188381408 0.421465253242843 no 1972 0.428268487226124 2722 762713 SGTC_1642 st009582 77.7 µM -0.18171476117747 0.42107029111778 no 1973 0.427903290548179 2829 6739311 SGTC_2837 9008476 45.46 µM -0.182591846439477 0.42069810335123 no 1974 0.427559141194617 2935 2992805 SGTC_753 1322-0200 289 µM -0.183463068489703 0.420328473780942 no 1975 0.427217346997672 2875 5403907 SGTC_414 piperonyl butoxide 100 µM -0.183655035626009 0.420247038156729 no 1976 0.427142042587974 2727 5794 A potent inhibitor of cytochrome P450. SGTC_2097 5376186 200 µM -0.183885813007006 0.420149143106173 no 1977 0.427051517302657 2824 742755 SGTC_2052 5265182 7.135 µM -0.183930211508698 0.420130309965619 no 1978 0.427034101881077 2860 1239884 SGTC_2277 7947813 106.88 µM -0.184145546943703 0.420038970683023 no 1979 0.42694963804481 2966 1246798 SGTC_268 camptothecin 39.6153 µM -0.185034154784185 0.419662093640852 no 1980 0.426601123229005 2734 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2145 5634607 200 µM -0.185307026239825 0.419546377958463 no 1981 0.42649411366477 2732 308662 SGTC_3177 9107506 49.47 µM -0.186423166941136 0.419073132447084 no 1982 0.426056463136581 2831 8897194 SGTC_1450 4112-4260 37.6 µM -0.186659420114216 0.418972975698316 no 1983 0.425963837437153 2783 1633175 SGTC_3300 9124615 50.48 µM -0.188767593370266 0.418079473717542 no 1984 0.425137485956907 2925 24824903 SGTC_1292 0kpi-0043 232 µM -0.189235872282481 0.417881061400421 no 1985 0.424953976772932 2796 3333905 SGTC_2133 5320837 200 µM -0.189253208256227 0.417873716455126 no 1986 0.424947183461817 2890 2841355 SGTC_2189 6047310 154.431 µM -0.192196979354633 0.416626910201472 no 1987 0.423793955960767 2718 711535 SGTC_1847 st056231 15 µM -0.192362245429975 0.416556938062461 no 1988 0.423729231933686 2749 5393180 SGTC_1984 st072354 53.1 µM -0.193109727313038 0.416240494149246 no 1989 0.423436517374798 2733 5762938 SGTC_2005 4024620 188 µM -0.193593839842798 0.416035575707736 no 1990 0.423246961017465 2740 236743 SGTC_1571 st070080 73.4 µM -0.193843586990793 0.415929869958895 no 1991 0.423149178383705 2890 4315245 SGTC_1716 st033144 30.6155 µM -0.194247488860169 0.415758930933133 no 1992 0.422991050107914 2874 674617 SGTC_3140 9094243 49.47 µM -0.194906455746863 0.415480077723049 no 1993 0.422733090081705 2700 19291112 SGTC_3153 9100258 49.47 µM -0.194928058361518 0.415470936923606 no 1994 0.422724634054596 2779 25236848 SGTC_1951 sophoraflavanone G 9.2 µM -0.195342866477568 0.415295426409287 no 1995 0.422562270403741 2740 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_216 k038-0035 28.382 µM -0.196660017905363 0.414738235322287 no 1996 0.422046800051543 2765 4444231 YPR107C YTH1 SGTC_1590 st077108 57.8 µM -0.196960328251892 0.414611219797727 no 1997 0.421929291540022 2792 5489485 SGTC_111 0083-0039 52.457 µM -0.196985456404697 0.414600592311693 no 1998 0.42191945945372 2731 759313 SGTC_37 0566-0070 1.56 µM -0.200166555383176 0.413255712929615 no 1999 0.420675161380232 2869 1626686 SGTC_944 3370-0224 231 µM -0.200331769929284 0.413185892507569 no 2000 0.420610558660512 2792 4580514 SGTC_959 1222-0044 107 µM -0.202144133975991 0.412420159903162 no 2001 0.419902023025682 2845 6083612 SGTC_2597 laccaic acid a 100 µM -0.202901275860361 0.412100362300444 no 2002 0.419606098516108 2888 5491415 A textile dye. SGTC_293 4049-0273 38.5 µM -0.202966884163518 0.412072653755466 no 2003 0.419580458029594 2786 1380311 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.20296909872017 0.412071718482979 no 2004 0.419579592561103 2782 390807 SGTC_62 0180-0423 3.232 µM -0.203529783984778 0.4118349406688 no 2005 0.419360484287212 2806 30102 YGL099W LSG1 SGTC_2208 7283366 200 µM -0.206032008370895 0.410778641827555 no 2006 0.418382954290227 2833 898663 SGTC_2674 ligustilide 100 µM -0.206801465372041 0.410453949881282 no 2007 0.418082455844608 2867 5319022 A signalling regulator. SGTC_2541 muurolladie-3-one 83.07 µM -0.207423568447956 0.410191482522345 no 2008 0.417839538934794 2947 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_2815 7968870 71.43 µM -0.207518474025486 0.41015144507675 no 2009 0.417802483247962 2784 2977326 YHR190W ERG9 SGTC_3317 9138495 8.753 µM -0.207572377073898 0.410128705625095 no 2010 0.417781437238919 2777 17020139 SGTC_2861 9024595 19.48 µM -0.209343780314386 0.409381592939064 no 2011 0.4170899385472 2826 16482810 SGTC_2481 5478948 45.16 µM -0.209595184200322 0.409275586630871 no 2012 0.416991819306047 2915 77792 SGTC_1694 st024011 44.9 µM -0.210425142338601 0.40892567578284 no 2013 0.416667935584024 2795 2787533 SGTC_245 methotrexate 289.6 µM -0.211440090799076 0.408497871563919 no 2014 0.41627193794319 2846 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_1351 1496-0003 46.5 µM -0.21291833651102 0.407874981129686 no 2015 0.415695329917314 2907 3891978 SGTC_3185 9108267 49.47 µM -0.213398826439741 0.407672566478204 no 2016 0.415507947894563 2860 4910486 SGTC_1825 st052143 62.6 µM -0.213743725260807 0.40752728710518 no 2017 0.415373455692669 2954 674173 SGTC_251 melphalan 456.522 µM -0.21401256422134 0.407414054726023 no 2018 0.415268629667363 2851 460612 A DNA alkylator. SGTC_850 0388-0143 75.9 µM -0.215103534637043 0.406954627989255 no 2019 0.414843299083908 2795 67273 SGTC_2102 5377816 72.7585 µM -0.215749636614892 0.40668260344888 no 2020 0.414591453913617 2972 1379702 SGTC_1545 lovastatin 49.4 µM -0.216246918839333 0.406473266273099 no 2021 0.414397641345188 2840 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_538 2922-0838 53.3 µM -0.21731375003102 0.406024260578996 no 2022 0.413981921079703 2935 777039 SGTC_607 4491-0986 66.8 µM -0.21890704304944 0.405353908996523 no 2023 0.413361229983987 2922 698981 YDR232W HEM1 SGTC_2824 7998404 51.95 µM -0.219074796084149 0.405283345807869 no 2024 0.413295891851742 2780 837851 SGTC_3340 9146634 11.102 µM -0.219715125978667 0.405014027473834 no 2025 0.413046511841209 2864 4907387 SGTC_2188 6126565 140.678 µM -0.219760059557905 0.404995130408018 no 2026 0.413029013527018 2898 874518 SGTC_2679 rapamycin 1 nM -0.221084566747333 0.404438201255896 no 2027 0.412513293447923 2879 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_2506 ethyl hematommate 54.16 µM -0.221882411686913 0.404102816542545 no 2028 0.412202711359669 2854 3940691 An allergen. SGTC_1970 st070122 35.8 µM -0.222967887152263 0.403646635726702 no 2029 0.411780249853292 2971 102928 SGTC_3355 9151058 44.0485 µM -0.223468267184215 0.403436390613447 no 2030 0.41158553889855 2782 17015728 SGTC_860 0443-0016 25.1 µM -0.223649696292357 0.403360166277288 no 2031 0.41151494546401 2805 5337942 SGTC_3041 9091929 49.47 µM -0.228361133997077 0.401382029957641 no 2032 0.409682750884906 2980 25236887 SGTC_2617 dihydrotanshinone i 20.83 µM -0.230117370514002 0.400645302705236 no 2033 0.409000283673846 2814 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_557 1315-0110 16.2 µM -0.231330550674439 0.400136589422438 no 2034 0.4085290071325 2817 6833801 SGTC_3099 9120367 49.47 µM -0.233370135521175 0.399281728572866 no 2035 0.407737000693778 2805 24824940 SGTC_3083 9117465 49.47 µM -0.233378398708825 0.399278266163031 no 2036 0.407733792718064 2920 16420915 SGTC_1706 st031321 9.9705 µM -0.233641673030652 0.399167954095219 no 2037 0.407631586294058 2916 6103185 SGTC_2234 tolnaftate 200 µM -0.23381291681608 0.399096207187656 no 2038 0.407565110663119 2850 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_1778 st046819 58.9 µM -0.234681547517962 0.398732324969163 no 2039 0.407227955374918 2832 671715 SGTC_1658 st012944 20 µM -0.236564907781071 0.397943660237525 no 2040 0.406497173509959 2881 24207260 SGTC_3174 9107204 49.47 µM -0.23692003639008 0.397794995308035 no 2041 0.406359412831506 2947 3938802 SGTC_2933 9026794 32.47 µM -0.237186357179064 0.397683517092336 no 2042 0.406256109883837 2878 17586027 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.239166319545929 0.3968549946312 no 2043 0.405488308990925 2921 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_1300 1094-0077 113 µM -0.239250707205361 0.396819692621812 no 2044 0.405455592728187 2829 5532636 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.239945587201897 0.396529034660188 no 2045 0.405186219744531 2994 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1065 prochlorperazine maleate 2.48 µM -0.240141588667137 0.396447060552092 no 2046 0.405110247114964 2847 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_1193 1488-0126 41.5 µM -0.240840769411473 0.396154678019198 no 2047 0.404839265025433 2850 1384710 SGTC_192 3455-0609 60.9 µM -0.241020434432483 0.396079555350151 no 2048 0.404769639460597 2959 3769639 SGTC_1446 4239-0190 62 µM -0.241148250457308 0.396026114458712 no 2049 0.404720108766507 2851 1340085 SGTC_1414 3917-0015 5.4 µM -0.24162664047095 0.395826113159676 no 2050 0.404534738764916 2872 6618702 SGTC_1081 sertraline 6 µM -0.242243730464965 0.395568165841857 no 2051 0.404295655948158 2948 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_2690 usnic acid 100 µM -0.24421417449519 0.394744815147008 no 2052 0.403532474856066 3071 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_311 1315-0136 58 µM -0.24426541341024 0.394723411201891 no 2053 0.40351263417893 3008 6759207 SGTC_2219 9098279 200 µM -0.244444194476302 0.394648731779347 no 2054 0.403443408713459 2865 902349 SGTC_1179 1021-1431 9.29 µM -0.246043868375579 0.393980697578714 no 2055 0.402824137005119 2910 2840958 SGTC_3118 9124250 49.47 µM -0.246399799758777 0.39383210066423 no 2056 0.402686380615235 2907 1504786 SGTC_1637 st007924 17.4 µM -0.24686155865604 0.393639345119126 no 2057 0.402507683728557 2824 683336 SGTC_2356 9061756 188.97 µM -0.247314999129481 0.393450087356939 no 2058 0.402332225824611 2923 20104043 SGTC_1424 4048-1941 275 µM -0.247702684607247 0.393288294487144 no 2059 0.402182227288605 2964 X1424 SGTC_1115 galangin 695.678 nM -0.247952348191624 0.393184112078748 no 2060 0.402085638123295 2900 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2537 larixol 68.93 µM -0.248173893432584 0.393091669611915 no 2061 0.401999932312632 2792 6708759 SGTC_3259 9138485 49.47 µM -0.248291109351763 0.393042762271274 no 2062 0.401954588692955 3141 17646153 SGTC_695 3505-6186 243 µM -0.249155699297366 0.392682071702827 no 2063 0.401620172897651 2965 1819379 SGTC_978 1416-0512 87.4 µM -0.249186408290221 0.39266926218474 no 2064 0.401608296252275 2919 6814003 SGTC_1730 st033808 45.1 µM -0.252127504806185 0.391442995155983 no 2065 0.400471255392593 2835 1045166 SGTC_73 0327-0325 16.231 µM -0.252144117400718 0.391436071716126 no 2066 0.400464835275555 2987 53298 SGTC_3155 9099265 49.47 µM -0.252592299185193 0.391249301138049 no 2067 0.400291640726839 2954 25236499 SGTC_1704 st028805 70.8 µM -0.252887991568544 0.391126091119813 no 2068 0.40017738463583 2902 2876101 SGTC_2039 Aminomethylbenzodioxan 200 µM -0.253798150175921 0.390746912034823 no 2069 0.399825751305718 2842 15053 SGTC_2778 tioconazole 65.09 nM -0.253802561411916 0.390745074532557 no 2070 0.399824047253491 2807 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_235 0330-0087 5 mM -0.255352897859544 0.390099432592444 no 2071 0.39922527356435 2879 46494818 YHR062C RPP1 SGTC_2159 5658611 73.75 µM -0.256070008612362 0.389800892214943 no 2072 0.398948389862599 2925 793844 SGTC_366 0181-0206 4.31 µM -0.256785402253602 0.389503131454688 no 2073 0.39867221981204 3024 274874 SGTC_817 1391-0715 46 µM -0.258772114335005 0.388676563862647 no 2074 0.397905537361999 2906 1353946 SGTC_2018 5133068 143 µM -0.260193983571761 0.388085307053566 no 2075 0.397357072447858 2831 785362 SGTC_1321 1326-2144 215 µM -0.260285391819554 0.38804730555932 no 2076 0.39732182000486 2987 3513030 SGTC_2055 5235184 200 µM -0.261412401405032 0.387578857824825 no 2077 0.39688724725537 3032 2836034 SGTC_2565 isoliquiritigenin 100 µM -0.261715988091191 0.387452698292425 no 2078 0.396770206672059 3011 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_3127 9126946 49.47 µM -0.261824866867715 0.387407455146448 no 2079 0.396728233329771 2948 27243249 SGTC_1165 k072-0275 30.3 µM -0.261829980470347 0.387405330293608 no 2080 0.396726262038414 2942 6153523 YGL055W OLE1 SGTC_633 0437-0093 97.7 µM -0.262721885932182 0.387034768900231 no 2081 0.396382473331067 2874 2831118 SGTC_1830 st055982 50.3 µM -0.263197546680997 0.386837187430422 no 2082 0.396199160814084 2944 455313 An antimicrobial agent. SGTC_1521 st012942 49.4 µM -0.263465314378959 0.386725974132208 no 2083 0.39609597725297 3087 24207259 SGTC_3047 9092122 49.47 µM -0.26538990582232 0.385926898141814 no 2084 0.395354555723124 2936 17173831 SGTC_1033 k072-0102 21.3 µM -0.266714388650185 0.385377263557712 no 2085 0.394844537289216 3062 5965931 SGTC_1342 1486-1464 234 µM -0.26685143656391 0.385320404462116 no 2086 0.394791774536291 2872 3253938 SGTC_1166 k206-0078 225 µM -0.267188790173752 0.385180452083355 no 2087 0.394661903327274 2879 5404595 SGTC_639 0833-0042 114 µM -0.268070855761465 0.384814594656145 no 2088 0.394322389392428 2895 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_2587 piperic acid 92.2 µM -0.268338568244993 0.384703574882209 no 2089 0.394219360633493 2956 5370536 SGTC_1581 himbacine 57.9 µM -0.268498441416103 0.384637280340268 no 2090 0.394157837205868 2873 5281825 An alkaloid muscarinic receptor antagonist. SGTC_10 0279-0212 42.575 µM -0.268904793331462 0.384468793746535 no 2091 0.394001474123879 2895 39851 YBR002C RER2 SGTC_1674 st016616 23.6 µM -0.270848699088551 0.383663090221035 no 2092 0.393253701392522 2828 625830 SGTC_1304 1165-0502 251 µM -0.271355321317156 0.383453189585091 no 2093 0.393058880834128 2903 767425 SGTC_764 1951-2361 146 µM -0.271728437616381 0.383298624178906 no 2094 0.392915416834438 2902 5438930 SGTC_749 1000-0129 128 µM -0.271778667370227 0.383277817654949 no 2095 0.392896104499122 3041 708470 SGTC_2213 7173844 200 µM -0.272293393511122 0.383064623563726 no 2096 0.392698217798148 2908 892728 SGTC_2553 4-methylesculetin 85.09 µM -0.272820301735925 0.38284642046514 no 2097 0.392495676415305 2936 5319502 SGTC_565 1418-0001 44.5 µM -0.273239447567329 0.382672870446551 no 2098 0.392334579247532 3069 2862145 SGTC_91 0417-1751 58.384 µM -0.273488014177095 0.382569960973577 no 2099 0.392239052292749 2848 6795624 SGTC_957 1187-1561 14.1 µM -0.273575706664793 0.382533657240036 no 2100 0.392205352628857 2859 1538454 SGTC_3349 9149703 23.001 µM -0.27376890801454 0.382453677631188 no 2101 0.392131109435057 2847 4910494 SGTC_2866 9034245 58.44 µM -0.274207771586711 0.382272019808618 no 2102 0.391962478038163 2964 6462273 SGTC_1213 1315-0166 115 µM -0.275250810679417 0.381840380986795 no 2103 0.391561776334839 3003 768401 SGTC_1549 4'-methoxyflavonol 74.6 µM -0.276333533714935 0.381392475180401 no 2104 0.391145951027981 2899 97141 SGTC_86 0417-1630 471.922 µM -0.277191882809837 0.381037502228679 no 2105 0.390816386052934 2950 3634867 SGTC_3282 9108498 15.4605 µM -0.277569074447391 0.380881545084401 no 2106 0.390671587298624 2988 16459645 SGTC_3075 9116269 49.47 µM -0.278028068265503 0.380691791356044 no 2107 0.390495406245471 3104 17015205 YNL244C SUI1 SGTC_2504 purpurogallin 52.29 µM -0.278092062051209 0.380665337810927 no 2108 0.390470844534961 2877 5281571 An antioxidant. SGTC_432 NS 1619 61.3 µM -0.279378192025911 0.380133799983036 no 2109 0.389977302646139 3066 4552 A K+/calcium channel activator. SGTC_3062 9077494 49.47 µM -0.281819363597864 0.379125524316554 no 2110 0.389041011242708 3035 16459633 SGTC_2774 tamoxifen 10.92 µM -0.282409175982198 0.378882037455897 no 2111 0.388814889912053 2862 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_3016 9080866 49.47 µM -0.283234809365709 0.37854127950437 no 2112 0.388498423178039 2916 17066299 SGTC_797 k781-0471 270 µM -0.283706583450106 0.378346609824181 no 2113 0.388317624546925 2924 23738129 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.283722617030893 0.378339994377602 no 2114 0.388311480400661 2965 676296 Flavone; oxidizing agent. SGTC_94 0334-0113 514.748 µM -0.284609569329182 0.377974093950316 no 2115 0.387971639538842 2933 6795178 SGTC_1261 0712-0010 12.7 µM -0.286252382872273 0.377296662264931 no 2116 0.387342412861946 3092 2840123 SGTC_284 0988-0104 32.6 µM -0.2865126651389 0.377189366677627 no 2117 0.387242747252991 2995 4666532 SGTC_3028 9087778 49.47 µM -0.287834950083342 0.376644430641706 no 2118 0.386736541334687 2904 17217395 SGTC_927 2425-1185 123 µM -0.287867427859745 0.376631049086899 no 2119 0.386724110396681 2873 730375 SGTC_1974 st069448 26.9 µM -0.28872993909539 0.376275729866357 no 2120 0.386394024950561 3060 6323587 YNR016C ACC1 SGTC_3058 9093861 49.47 µM -0.289317001598208 0.376033944155844 no 2121 0.386169401496451 3096 17217477 SGTC_1602 st001878 87.6 µM -0.289916895546389 0.375786923986487 no 2122 0.385939907848541 3093 595405 YLR310C CDC25 SGTC_595 3909-8003 73.7 µM -0.290263140209099 0.375644372920479 no 2123 0.385807467678602 3041 699517 SGTC_2890 9046729 58.44 µM -0.292000732521321 0.374929252121816 no 2124 0.385143031948139 2942 903329 SGTC_3148 9097893 49.47 µM -0.292520855153056 0.37471527472657 no 2125 0.384944208370952 2932 17174100 SGTC_373 0844-0104 25.9 µM -0.292644828658222 0.374664277967739 no 2126 0.384896822363614 3055 5375804 SGTC_2825 7998094 58.44 µM -0.292786452744215 0.374606023288157 no 2127 0.384842691933404 2979 2987815 SGTC_2943 9068529 45.32 µM -0.292998165156518 0.374518944294428 no 2128 0.38476177708716 2903 3270634 SGTC_44 0929-0055 61.211 µM -0.29309594115896 0.374478730409331 no 2129 0.384724409549449 2895 1379590 SGTC_1220 1838-0075 193 µM -0.29382260180265 0.374179907983694 no 2130 0.38444673163712 2946 5529645 SGTC_740 k014-0057 261 µM -0.294354028574739 0.373961418821093 no 2131 0.384243695719023 3027 4012779 SGTC_2654 protoveratrine a 100 µM -0.295280736732292 0.37358051178734 no 2132 0.383889715341483 2933 5702278 A heart drug and vasodilator. SGTC_1042 0350-0096 82 µM -0.295941414049099 0.373309027400904 no 2133 0.383637411509777 2911 3122515 SGTC_3248 9135562 49.47 µM -0.296752065171598 0.372976001954955 no 2134 0.383327902090205 2978 17650701 SGTC_1840 st055363 71 µM -0.297840225425 0.372529121568163 no 2135 0.382912555789783 2960 676033 SGTC_1158 4092-0494 91.8 µM -0.297889185913602 0.37250901874023 no 2136 0.382893870933094 3072 1148199 SGTC_3150 9097574 49.47 µM -0.298488987121907 0.372262772841884 no 2137 0.382664990127535 3090 17217476 SGTC_1488 4013-0813 75.9 µM -0.300215057162624 0.371554433633319 no 2138 0.382006560276024 2943 2910057 SGTC_157 1348-1695 65.819 µM -0.301305484222482 0.371107171493043 no 2139 0.381590779663237 2931 5380510 SGTC_578 3460-0051 92 µM -0.301763505075659 0.37091935624749 no 2140 0.381416176694357 3041 2876744 SGTC_1017 4239-0030 168 µM -0.302326594636304 0.370688498847333 no 2141 0.381201553363595 2945 1149593 SGTC_835 0312-0010 67.2 µM -0.305489795306586 0.369392506316751 no 2142 0.37999657046086 2915 1626196 SGTC_1234 0326-0494 15.5 µM -0.306354127338352 0.369038638814938 no 2143 0.3796675156595 3083 1547813 SGTC_3123 9126162 49.47 µM -0.307419875717773 0.368602461931882 no 2144 0.379261900777422 2916 25239884 SGTC_59 0330-0160 1.33 µM -0.308813600954717 0.368032309996939 no 2145 0.378731661220215 2989 4293482 SGTC_828 2074-0507 139 µM -0.309832964451657 0.367615487702524 no 2146 0.378343991139715 3099 X828 SGTC_399 oxolinic acid 75 µM -0.310389237728322 0.367388090786921 no 2147 0.378132488667806 2949 4628 A DNA gyrase inhibitor. SGTC_1323 1348-1351 11.2 µM -0.311331959027351 0.367002825404411 no 2148 0.377774136945256 2973 6989654 SGTC_2718 lomofungin 53.02 µM -0.311993903343875 0.366732386177695 no 2149 0.37752257833696 3115 5351222 A RNA synthesis inhibitor. SGTC_2138 5575593 77.673 µM -0.31215774638755 0.366665457844038 no 2150 0.377460321103775 2973 762213 SGTC_2023 5144124 124 µM -0.312448585540536 0.366546662786755 no 2151 0.377349815613513 2954 2830192 SGTC_2240 6690706 185.951 µM -0.314634746704018 0.365654121617057 no 2152 0.376519497007047 2868 805876 SGTC_175 3793-3120 23.7 µM -0.314696201411904 0.365629042064589 no 2153 0.376496164332187 2960 5322297 SGTC_974 1326-0144 138 µM -0.315496416942413 0.365302528058091 no 2154 0.37619238556248 2990 5411856 SGTC_1987 st072290 61.9 µM -0.317222344554002 0.364598625931395 no 2155 0.375537448163503 3015 54697379 SGTC_2666 tannic acid 100 µM -0.317585710765235 0.36445048875918 no 2156 0.375399607283621 3040 16134267 A thiamine antagonist. SGTC_3077 9117319 49.47 µM -0.317812323330965 0.364358113573571 no 2157 0.3753136511637 2937 17154678 SGTC_1611 st001856 99.4 µM -0.317986741875767 0.364287019856179 no 2158 0.37524749690619 2997 647478 SGTC_1241 0364-0022 50.8 µM -0.31921264755387 0.363787467513888 no 2159 0.374782633456134 3003 4563895 SGTC_3178 9107506 49.47 µM -0.320539575083252 0.363247009962729 no 2160 0.374279667514111 3113 8897194 SGTC_2511 berberine 10.47 µM -0.321425510776585 0.362886319813355 no 2161 0.373943976576504 2987 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1526 st051518 75 µM -0.323328469236549 0.362111981647458 no 2162 0.373223247786728 3019 673993 SGTC_1425 4048-4433 7.33 µM -0.32394738513001 0.361860258235072 no 2163 0.372988934257473 3055 23734946 SGTC_1839 st053978 48 µM -0.32427561181475 0.361726787210015 no 2164 0.372864690948433 3064 3788398 SGTC_1265 0819-1001 68.8 µM -0.325459340572098 0.361245572225206 no 2165 0.372416725244775 2992 3106768 SGTC_2031 5180455 200 µM -0.325629490837906 0.36117641996165 no 2166 0.372352348410925 2981 29949 SGTC_581 0958-0271 211 µM -0.326096307451281 0.360986720224484 no 2167 0.37217574534765 2987 4591145 SGTC_150 3970-0969 77.2 µM -0.3281956134427 0.360134050817651 no 2168 0.371381882149473 3092 6615640 SGTC_2982 9019404 25.97 µM -0.32823204450489 0.360119259838452 no 2169 0.371368110376294 2996 22333232 SGTC_2749 bexarotene 57.39 µM -0.328644534621456 0.35995180382691 no 2170 0.371212191187717 3071 82146 An retinoic acid receptor inhibitor. SGTC_1500 4488-1866 171 µM -0.328699590379559 0.359929455220191 no 2171 0.371191381986403 3113 2900003 SGTC_2539 epi(13)torulosol 80 µM -0.329145521486982 0.359748457492513 no 2172 0.371022849099047 3096 6708597 SGTC_2136 5328288 199.296 µM -0.330596003742487 0.359159943026331 no 2173 0.370474832597515 3003 262395 SGTC_113 0099-0221 2.5 µM -0.331144280652696 0.35893757366329 no 2174 0.370267752761516 3178 89219 SGTC_433 pimozide 108 µM -0.33157684762781 0.358762167493878 no 2175 0.370104402176687 2932 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_699 0375-0592 111 µM -0.331579424108527 0.358761122818583 no 2176 0.370103429288538 3124 762578 SGTC_829 1635-0120 117 µM -0.332368119813248 0.358441383236698 no 2177 0.36980565412247 3126 285054 SGTC_172 1112-0046 2.638 µM -0.332437949363435 0.358413078907489 no 2178 0.369779293459677 3008 2802135 YIL048W NEO1 SGTC_41 0478-0632 82.643 µM -0.333423724316064 0.358013593326807 no 2179 0.369407228654891 3058 3750424 SGTC_1386 3228-0095 33.8 µM -0.334135749762143 0.357725141457657 no 2180 0.369138562206541 3126 870181 SGTC_1817 st052116 64.4 µM -0.334351209339215 0.357637871650349 no 2181 0.369057276074222 3127 4361398 SGTC_3304 9125678 46.087 µM -0.33450966788671 0.357573694305137 no 2182 0.368997498376964 2993 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_579 4491-1009 110 µM -0.334656343581159 0.357514292725819 no 2183 0.368942168526099 3118 1271041 SGTC_1667 st014849 34.6 µM -0.334791231821547 0.357459667945207 no 2184 0.368891287603805 2976 5348460 SGTC_2328 6201408 200 µM -0.335095742349815 0.357336363110065 no 2185 0.368776432248615 3122 2890418 SGTC_661 1304-0007 33.6 µM -0.335192981983312 0.357296991197937 no 2186 0.368739757848207 3018 3117130 SGTC_890 0929-0006 47.2 µM -0.335674499937763 0.35710204902989 no 2187 0.368558168632405 2999 1378169 SGTC_601 0986-0029 62.9 µM -0.335684689213236 0.357097924312474 no 2188 0.368554326387469 3015 24747981 SGTC_1050 3232-1156 69.3 µM -0.336459002798854 0.356784523563281 no 2189 0.368262381149723 3045 700529 SGTC_869 0564-0080 44.1 µM -0.33651397283705 0.356762278301821 no 2190 0.36824165827467 3030 6843321 SGTC_3330 9141424 71.43 µM -0.337179482860272 0.356492998538913 no 2191 0.367990801466662 3133 27261020 SGTC_93 0109-0045 59.227 µM -0.337215622611192 0.356478377659602 no 2192 0.367977180588631 3007 88733 SGTC_1927 st060202 13.8 µM -0.3372975069206 0.356445250912155 no 2193 0.36794631944634 3057 688887 SGTC_2121 5257820 149.641 µM -0.337848211425692 0.356222488525114 no 2194 0.367738788158127 3149 791256 SGTC_427 1354-0053 47.3 µM -0.338235705127779 0.356065775022626 no 2195 0.367592785493201 3204 6813657 SGTC_2924 9010168 62.78 µM -0.339201843392298 0.355675147088138 no 2196 0.367228840338171 3091 2993929 SGTC_1632 st005650 90 µM -0.339468755074224 0.355567256351943 no 2197 0.367128315477589 3107 2759605 SGTC_1511 0906-3109 28.5 µM -0.341204715677609 0.354865831048831 no 2198 0.366474736741095 3004 2882180 SGTC_612 0302-0167 22.4 µM -0.341655909251596 0.354683603983694 no 2199 0.366304928367317 3075 235821 SGTC_566 0958-0068 16.5 µM -0.344076792495794 0.353706431715394 no 2200 0.36539426772787 3179 6815365 SGTC_926 2268-1401 59.4 µM -0.345378261982415 0.353181500465872 no 2201 0.364905008655284 3014 2931578 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.347724352159461 0.352235940598131 no 2202 0.364023603124051 3019 165521 SGTC_1417 3966-0327 90.4 µM -0.347988593547421 0.352129498767853 no 2203 0.363924374905494 3065 651118 SGTC_2393 9031399 185.94 µM -0.34825663264768 0.35202153897631 no 2204 0.363823729887388 3147 1526623 YDL150W RPC53 SGTC_1882 5615643 20 µM -0.349068263927046 0.35169470591886 no 2205 0.363519030754913 3089 2253075 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.349291674628833 0.351604760641276 no 2206 0.363435174009676 3131 1377 SGTC_1104 tacrolimus 29.8 µM -0.349644878064328 0.351462577683745 no 2207 0.36330261318164 3059 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_1519 esterone 74 µM -0.350547094362038 0.351099482554731 no 2208 0.362964076610114 3002 698 A steroid. SGTC_2261 9010538 184.68 µM -0.35075514392649 0.351015772697053 no 2209 0.362886025825198 3113 6457250 SGTC_3107 9121808 49.47 µM -0.351184854971908 0.350842899044799 no 2210 0.362724835713689 3011 662681 SGTC_283 0987-0079 11.7 µM -0.351813908831412 0.350589885048756 no 2211 0.362488913434614 3125 411556 SGTC_308 4092-1169 104 µM -0.353148618281972 0.350053266374583 no 2212 0.361988512929342 3029 2268590 YDL196W YDL196W SGTC_2900 5328528 85.29 µM -0.353608456317837 0.349868458190566 no 2213 0.361816168047656 3023 795359 SGTC_1277 0873-0036 22 µM -0.354496575779018 0.349511625074129 no 2214 0.361483384887129 3125 5965735 SGTC_1530 rhein 70.4 µM -0.356775158425225 0.348596733348417 no 2215 0.360630067360556 3016 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_993 3909-8757 62.7 µM -0.357564095434715 0.348280165811831 no 2216 0.360334775904643 3049 4288324 YLR208W SEC13 SGTC_2592 piperlongumine 83.33 µM -0.357886274886753 0.348150919001895 no 2217 0.360214211208809 3112 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_1303 1160-0052 261 µM -0.357969914803636 0.348117368557868 no 2218 0.360182914088612 3071 3562476 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.357988739459815 0.348109817595473 no 2219 0.360175870242266 3043 4620898 SGTC_2560 caryophyllene 100 µM -0.359028579378071 0.347692809716588 no 2220 0.359786854716963 3014 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_2108 5365811 200 µM -0.359821309974623 0.34737502400969 no 2221 0.359490383026284 3149 780283 SGTC_1603 st002045 67.8 µM -0.360146099399199 0.347244855080262 no 2222 0.359368940103983 3162 5887985 SGTC_2488 5268135 45.7 µM -0.360666096513017 0.347036488438881 no 2223 0.359174536109322 3171 1270356 YLR208W SEC13 SGTC_1489 4065-0444 182 µM -0.360947763430549 0.346923641750718 no 2224 0.359069248486215 3158 2877968 SGTC_1670 st016595 4.04 µM -0.364515826296323 0.345495315646789 no 2225 0.357736428933775 3105 597879 SGTC_3303 9125618 40.5795 µM -0.365761850614362 0.344997037996185 no 2226 0.357271394505988 3111 22695467 SGTC_2931 9014674 55.67 µM -0.368086963335665 0.344067958306899 no 2227 0.356404195650613 3013 2996810 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.368556985231304 0.343880258807175 no 2228 0.35622898127976 3034 688803 SGTC_900 1112-0045 141 µM -0.368792463771166 0.343786236789884 no 2229 0.356141211195026 3091 56211 YIL048W NEO1 SGTC_648 0375-0473 33.3 µM -0.369613887993556 0.343458333678808 no 2230 0.355835100850428 3053 1713139 SGTC_3292 9120825 59.784 µM -0.369921644494093 0.343335511137199 no 2231 0.355720436834614 3226 24824900 SGTC_576 1073-0113 22.7 µM -0.369996699316131 0.343305560017166 no 2232 0.355692474864432 3162 5439563 SGTC_2651 TUB2.036 5 µM -0.370763787953533 0.342999504711635 no 2233 0.35540673751174 3220 15992207 YFL037W TUB2 SGTC_951 1171-0579 82.7 µM -0.371408642455334 0.342742298406474 no 2234 0.355166594728876 3026 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_1849 st056239 19.2 µM -0.371525508162433 0.342695693213419 no 2235 0.355123080279814 3037 5393181 SGTC_1863 st057641 20.1 µM -0.372557448606131 0.342284266858076 no 2236 0.354738923698801 3134 3921635 SGTC_976 1348-1067 47.6 µM -0.373881314310502 0.341756726299229 no 2237 0.354246309479936 3054 5310671 YGL099W LSG1 SGTC_1721 st082152 9.2685 µM -0.374708970290016 0.341427074691558 no 2238 0.353938460111493 3028 5296051 SGTC_1659 st012954 42.1 µM -0.375542226004334 0.34109531490219 no 2239 0.353628624333168 3180 24207262 SGTC_2499 avocadenofuran 51.48 µM -0.375758843123461 0.341009089152184 no 2240 0.353548093819033 3027 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_1066 ketoconazole 628 nM -0.375838149737074 0.340977522752838 no 2241 0.353518612089409 3210 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_3011 9081274 71.4286 µM -0.376417086661846 0.340747122312342 no 2242 0.353303422597938 3068 6625322 SGTC_925 2064-1272 59.6 µM -0.376475217007385 0.340723991367195 no 2243 0.353281818274799 3082 6815817 SGTC_479 n-linoleoylglycine 10 µM -0.376679382031434 0.340642755757201 no 2244 0.353205943457437 3078 6433346 An anti-infammatory. SGTC_1907 st060210 83.7 µM -0.377648783988971 0.340257139485461 no 2245 0.352845759676716 3211 688793 SGTC_3269 9137823 49.47 µM -0.377651172856351 0.340256189429271 no 2246 0.352844872249643 3035 17682936 SGTC_1053 3366-3204 134 µM -0.378435846312347 0.33994417850396 no 2247 0.35255342161301 3104 3632071 YPR165W RHO1 SGTC_2588 indole-3-carbinol 100 µM -0.379691762441581 0.339445014787553 no 2248 0.352087117839919 3193 3712 Induces cell cycle arrest. SGTC_3275 9138069 49.47 µM -0.380765885213924 0.339018328141241 no 2249 0.351688487696502 3165 17617007 SGTC_3223 9129970 49.47 µM -0.381429319208646 0.338754887397989 no 2250 0.351442354428698 3027 17248386 SGTC_281 1672-3440 14.9 µM -0.38211177585111 0.338483975296748 no 2251 0.351189228761866 3174 6833000 SGTC_2480 5767542 37.17 µM -0.382116589501174 0.338482064737855 no 2252 0.351187443595724 3094 2867358 SGTC_1328 1441-0025 69.2 µM -0.382485951423668 0.338335475767407 no 2253 0.351050473679191 3053 4562601 SGTC_19 0279-0214 38.434 µM -0.382808786776143 0.338207371897869 no 2254 0.350930772985578 3086 3566274 YBR002C RER2 SGTC_3321 9137793 26.8275 µM -0.384515872552108 0.337530297091594 no 2255 0.350298066932784 3158 4904192 SGTC_2892 9047358 58.44 µM -0.384986489937433 0.3373437302794 no 2256 0.350123712509716 3106 6466771 SGTC_861 0443-0273 110 µM -0.385172565987146 0.337269975193631 no 2257 0.350054783729296 3174 6149169 SGTC_298 1391-0729 10 µM -0.385373282712812 0.33719042398415 no 2258 0.349980437092196 3068 3237558 SGTC_2172 5754775 163.918 µM -0.385611283608711 0.337096105158941 no 2259 0.349892287634872 3077 2263357 SGTC_1123 mangostin 811.285 nM -0.38569084211414 0.337064578717334 no 2260 0.349862822998895 3124 5281650 An antioxidant. SGTC_74 000s-0487 160.283 µM -0.38570512614437 0.337058918543072 no 2261 0.349857532978267 3149 677548 SGTC_1093 fluphenazine 7.97 µM -0.386793989813301 0.336627555283716 no 2262 0.349454363510093 3100 6602611 An atypical antipsychotic. SGTC_3231 9132313 49.47 µM -0.388919996379627 0.335785938187276 no 2263 0.348667664729954 3139 4905967 SGTC_2370 9071495 200 µM -0.389093256946356 0.335717386153874 no 2264 0.348603580711204 3156 21791103 SGTC_1732 st034308 51.822 µM -0.391034323987878 0.334949760426055 no 2265 0.347885932440299 2983 830119 SGTC_1523 st012844 44.7 µM -0.3922641062783 0.334463779845625 no 2266 0.347431540880598 3223 4274103 SGTC_309 k408-0051 1.48 µM -0.392356252191406 0.334427377138047 no 2267 0.347397502757611 3143 3640463 SGTC_2540 epiandrosterone 100 µM -0.392644554477844 0.334313491922606 no 2268 0.347291013648726 3104 441302 A steroid. SGTC_2800 7887935 81.82 µM -0.393358828612193 0.334031404946492 no 2269 0.34702723689532 3222 2961002 SGTC_23 0213-0011 39.996 µM -0.393965193439891 0.333792007953138 no 2270 0.346803368491737 3262 627608 SGTC_1285 0929-0069 65.5 µM -0.394222137184508 0.333690585198189 no 2271 0.346708521619082 3121 1206237 SGTC_826 1683-5028 118 µM -0.395622631223848 0.333137985509506 no 2272 0.346191719583314 3174 722377 SGTC_1116 jasmonic acid  1.58368 µM -0.395931049719862 0.333016339943099 no 2273 0.346077947244501 3234 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_2459 5811157 9.22 µM -0.396070060635877 0.332961517387095 no 2274 0.346026672121193 3131 2870684 YBR192W RIM2 SGTC_1167 k781-0610 148 µM -0.396212304916694 0.332905423365636 no 2275 0.345974207271548 3130 4525169 SGTC_1463 k081-0032 34.1 µM -0.396234236030889 0.332896775165077 no 2276 0.345966118544299 3162 977755 SGTC_1078 idebenone 36.1 µM -0.397089619592557 0.332559537083142 no 2277 0.34565068719117 3162 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_870 0573-2213 57.6 µM -0.397191032464469 0.332519563666876 no 2278 0.345613297266578 3163 3916321 SGTC_858 0438-0351 2.77 µM -0.397740499748034 0.332303015955268 no 2279 0.34541074029824 3136 2799119 SGTC_38 0929-0051 58.268 µM -0.398353091032597 0.332061656756947 no 2280 0.345184965328229 3226 1379719 SGTC_969 1313-0238 134 µM -0.398602846263033 0.331963273900396 no 2281 0.345092932027237 3097 5212874 SGTC_435 c-PAF 6.7 µM -0.399542883229007 0.331593081164176 no 2282 0.344746616232571 3228 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_1802 st050112 57.9 µM -0.400900712696 0.331058649343094 no 2283 0.344246612590698 3134 4662563 SGTC_13 0199-0087 65 µM -0.401996489153519 0.330627610448221 no 2284 0.343843305041681 3144 4589825 SGTC_572 0960-0087 17.7 µM -0.402739525370468 0.330335454534983 no 2285 0.343569926829608 3141 6796365 SGTC_2388 9080168 200 µM -0.403368050101114 0.330088404332981 no 2286 0.343338743587707 3098 15943073 SGTC_1035 k081-0041 55.2 µM -0.403536657501641 0.3300221434948 no 2287 0.343276736573966 3261 731709 SGTC_2683 piperine 63.03 µM -0.405379498629897 0.329298275374777 no 2288 0.342599289160564 3123 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1695 st026914 34.495 µM -0.405481305597041 0.329258304203929 no 2289 0.342561878597393 3103 3289191 SGTC_2432 5630864 12.22 µM -0.405593004030811 0.329214451717822 no 2290 0.3425208350367 3235 5714970 SGTC_1767 st044992 70.3 µM -0.407389087352664 0.328509637540465 no 2291 0.34186112030936 3165 9600693 SGTC_2519 cryptotanshinone 88.04 µM -0.407604075634293 0.328425313231621 no 2292 0.341782185820318 3264 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_3295 9122362 53.5725 µM -0.408073404072876 0.328241260094369 no 2293 0.341609892554431 3211 4730473 SGTC_2123 5259487 200 µM -0.408277062589924 0.328161405774186 no 2294 0.341535138562843 3230 2173474 SGTC_1199 1638-0010 4.46 µM -0.40901239446125 0.327873148195261 no 2295 0.341265282662561 3120 3111136 SGTC_2508 celastrol 40.54 µM -0.410827856240067 0.327161907991296 no 2296 0.340599382844504 3165 122724 Celastrol is a natural product and antioxidant. SGTC_358 0075-0058 9.45 µM -0.413096750791338 0.326273909074802 no 2297 0.339767864941822 3358 1069125 SGTC_392 N-ethylmaleimide 8.33 µM -0.413466469798706 0.326129301716075 no 2298 0.339632441849487 3136 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_2990 9074105 71.4286 µM -0.415332493173881 0.32539984750226 no 2299 0.338949258828681 3198 6502001 SGTC_948 3448-0295 75.3 µM -0.415637017840074 0.325280867983735 no 2300 0.33883781733175 3149 678569 SGTC_2365 9042475 200 µM -0.415787050496596 0.325222255919118 no 2301 0.338782917724264 3224 6464479 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.415942908159119 0.325161372824537 no 2302 0.338725890270523 3165 6708561 SGTC_3318 9139014 38.6185 µM -0.416054953408461 0.325117607173479 no 2303 0.338684895819655 3134 16643984 SGTC_1349 flufenamic acid 69 µM -0.418201963942739 0.324279436633487 no 2304 0.337899729995054 3115 3371 A non-steroidal anti-inflammatory. SGTC_2427 5545055 42.75 µM -0.418778360705356 0.324054568646748 no 2305 0.33768906046552 3127 5372858 SGTC_2558 carylophyllene oxide 100 µM -0.419036842055854 0.323953748911057 no 2306 0.337594603605596 3203 6708694 An oxygenated terpenoid and antifungal agent. SGTC_1051 3253-3903 78 µM -0.419724874959231 0.323685447060497 no 2307 0.337343225561006 3081 5509239 SGTC_2170 morpholine 200 µM -0.42095903099632 0.323204411395201 no 2308 0.336892499216456 3239 121171 Reacts with secondary amines. SGTC_1301 naphtanilide LB 4.81 µM -0.421286922640293 0.323076659067731 no 2309 0.33677278918879 3263 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_232 clozapine 119 µM -0.423909180882526 0.32205573311419 no 2310 0.335816024167219 3189 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_413 propylparaben 100 µM -0.424518529224936 0.321818686809231 no 2311 0.33559384750266 3139 7175 A pharmaceutical preservative. SGTC_2854 9024559 71.43 µM -0.424980939349266 0.32163885021178 no 2312 0.335425284850532 3226 3163529 SGTC_2035 5154463 94.595 µM -0.425310158629664 0.321510838522627 no 2313 0.335305294523832 3291 2769623 SGTC_2626 ethyl orsellinate 100 µM -0.425635703554549 0.321384276387739 no 2314 0.335186659906643 3122 75653 A natural product. SGTC_3114 9122766 49.47 µM -0.426432989088861 0.321074403206398 no 2315 0.334896183693929 3203 17176985 SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.427801457394391 0.320542824453011 no 2316 0.334397837895701 3166 3256 An antibiotic and ribosome inhibitor. SGTC_879 0831-1030 162 µM -0.427962205706434 0.320480406220454 no 2317 0.334339318403568 3172 1549252 SGTC_2611 pyromycin 23.93 µM -0.428236539075514 0.320373894875151 no 2318 0.3342394582273 3166 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_2274 7947094 46.08 µM -0.429033737279859 0.320064462550545 no 2319 0.33394933645474 3178 2971028 SGTC_1207 2099-0101 141 µM -0.429414018424993 0.319916900564568 no 2320 0.33381097690525 3244 5837381 SGTC_227 fluconazole 33.516 µM -0.429778192239172 0.319775615474118 no 2321 0.333678498941459 3202 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_1307 1187-1599 12.2 µM -0.430764190003749 0.319393218460174 no 2322 0.333319919986682 3128 1538471 SGTC_962 1254-0300 21.5 µM -0.431591712058366 0.31907243085036 no 2323 0.333019091590494 3140 7340576 SGTC_2510 benzyl isothiocyanate 8.31 µM -0.433085660308164 0.318493647285701 no 2324 0.332476269975855 3206 2346 DNA damaging agent; causes G2/M arrest. SGTC_519 k048-0011 62.8 µM -0.433499750652599 0.318333299213403 no 2325 0.332325873594667 3240 6836379 SGTC_842 0271-0008 11.1 µM -0.435865379166834 0.317417910894739 no 2326 0.331467202604457 3294 1221709 SGTC_2236 dapsone 200 µM -0.436276538328031 0.317258925038084 no 2327 0.331318051052893 3245 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_505 gw-5074 63.9 µM -0.437933372194931 0.316618607142013 no 2328 0.330717291513075 3280 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_652 0437-0092 114 µM -0.439697270115588 0.315937515595405 no 2329 0.330078190011696 3213 3091274 SGTC_1914 st062367 72.6 µM -0.440772984138251 0.315522457890665 no 2330 0.329688676766041 3153 978205 SGTC_3093 9117344 49.47 µM -0.440984986087672 0.315440685654117 no 2331 0.329611933181376 3298 24824913 SGTC_2712 st079126 47.7 µM -0.441176924014631 0.315366660198216 no 2332 0.329542458854715 3151 3152970 SGTC_3353 9151644 39.2805 µM -0.442528021904109 0.314845786780711 no 2333 0.329053578691695 3298 4909158 SGTC_2420 aureobasidin a 50 nM -0.442917970044377 0.314695522911074 no 2334 0.328912534480934 3393 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_334 1502-1024 68.5 µM -0.443859756649415 0.314332738400289 no 2335 0.328571990831339 3272 3296216 SGTC_323 4013-0906 34.3 µM -0.443924563246996 0.314307780915278 no 2336 0.328548562436191 3260 2910086 SGTC_1421 4029-0249 71.4 µM -0.444110764842289 0.31423607807047 no 2337 0.328481251982449 3329 2894095 SGTC_2689 tacrolimus 100 µM -0.444240983680886 0.31418593733129 no 2338 0.328434182174675 3239 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_3289 9119912 71.43 µM -0.445478175106935 0.31370972816961 no 2339 0.327987114266194 3295 17014829 SGTC_2344 7990960 76.95 µM -0.445551565082571 0.313681489266125 no 2340 0.327960602011392 3207 140813 SGTC_2148 5546263 113.568 µM -0.446356843902601 0.313371706818229 no 2341 0.327669750622209 3162 792097 SGTC_1513 0337-0559 19 µM -0.446406018906469 0.313352793963989 no 2342 0.327651992931198 3175 775073 SGTC_1161 k007-0610 110 µM -0.447407700141593 0.312967651235751 no 2343 0.327290358564299 3322 5843850 SGTC_3239 9133757 49.47 µM -0.447607189558421 0.312890972641784 no 2344 0.327218356758783 3240 17036923 SGTC_2398 5228213 48.84 µM -0.448328341328682 0.312613848011131 no 2345 0.326958124768151 3371 80771 YMR134W ERG29 SGTC_2950 9072895 21.46 µM -0.448752186422208 0.312451021970889 no 2346 0.32680521693844 3294 17332245 SGTC_3217 9129673 49.47 µM -0.451429496705053 0.311423342703295 no 2347 0.325840014085513 3349 17248312 SGTC_107 0358-0022 2.6945 µM -0.451488316748781 0.3114007812157 no 2348 0.32581882181385 3243 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_110 0850-0284 111.64 µM -0.452807208423809 0.310895082674733 no 2349 0.325343786269102 3091 3906265 SGTC_1477 0139-0234 16 µM -0.453525680103624 0.310619751422712 no 2350 0.32508512798462 3259 620880 SGTC_722 3534-0461 190 µM -0.453923859790072 0.310467207474211 no 2351 0.324941814883511 3243 658262 SGTC_1192 1488-0095 21.4 µM -0.454626838309557 0.310197973661119 no 2352 0.324688861620641 3280 915875 SGTC_2657 nystatin 74.44 µM -0.455773363097404 0.309759084263065 no 2353 0.324276480249192 3265 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1118 chelidonine 707.474 nM -0.456004920557034 0.309670477006543 no 2354 0.324193219931395 3304 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_1846 st056244 14.8 µM -0.457793958941811 0.308986260729181 no 2355 0.323550238174789 3246 5393182 SGTC_824 1304-0008 100 µM -0.458318558916664 0.308785753348681 no 2356 0.323361796279973 3210 768245 SGTC_3088 9117578 49.47 µM -0.458388549121375 0.308759006696367 no 2357 0.323336658477797 3320 678341 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -0.458682301206182 0.30864676083932 no 2358 0.323231162770966 3262 364106 SGTC_1002 4049-0206 172 µM -0.459746215090774 0.308240377489229 no 2359 0.322849196505952 3210 4662749 SGTC_567 1080-0542 68.4 µM -0.460619455703023 0.307907001145156 no 2360 0.322535825298535 3298 5950415 SGTC_2830 7992007 71.43 µM -0.460989004459476 0.307765966532685 no 2361 0.322403246937152 3163 1952075 SGTC_2270 7924575 90.91 µM -0.461752109743702 0.307474824865559 no 2362 0.322129548731216 3331 1262135 SGTC_2515 chrysin 20.77 µM -0.463506223194934 0.306806051399527 no 2363 0.321500777589736 3274 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_2362 9071156 126 µM -0.464224370159253 0.306532435860024 no 2364 0.321243501399769 3340 653133 SGTC_1356 1502-0781 85.8 µM -0.466286284379847 0.305747441627598 no 2365 0.320505297456859 3210 567702 SGTC_2571 chrysanthemic acid 100 µM -0.466610495886924 0.305624091657211 no 2366 0.320389288138859 3236 2743 An insecticide. SGTC_1280 0880-0253 10.1 µM -0.466658066982221 0.305605994545931 no 2367 0.320372267732035 3242 6836607 SGTC_1272 0839-0021 27 µM -0.467600393750649 0.30524761022957 no 2368 0.320035191645381 3292 5027250 SGTC_2327 6189656 200 µM -0.468564340763498 0.304881196416267 no 2369 0.319690535509475 3305 5349088 SGTC_3197 9113331 49.47 µM -0.469329343390046 0.304590544161101 no 2370 0.319417122052299 3398 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_726 3448-4391 34.2 µM -0.469513374669822 0.304520642396445 no 2371 0.319351363548274 3428 1356692 SGTC_1661 st013063 9.66 µM -0.470889333824554 0.303998229491918 no 2372 0.318859882646125 3250 721395 SGTC_249 wiskostatin 11.211 µM -0.471252771430515 0.303860309210509 no 2373 0.318730118942968 3330 2775510 A n-wasp and actin depolymerizer. SGTC_574 1315-0397 40 µM -0.471288080503455 0.303846911321748 no 2374 0.31871751318723 3263 6794277 SGTC_2921 7974240 10.71 µM -0.472345390683991 0.303445841289741 no 2375 0.318340138216264 3331 2979074 YDR527W RBA50 SGTC_134 0269-0018 6.916 µM -0.473081616365201 0.303166708167513 no 2376 0.318077475929878 3267 4378915 SGTC_659 k018-0002 107 µM -0.473418657445975 0.303038960503469 no 2377 0.317957260733317 3345 6797879 YHR007C ERG11 SGTC_1985 st071382 65.5 µM -0.473812449310919 0.302889733277866 no 2378 0.317816828067964 3285 6123237 SGTC_825 1988-2224 89.6 µM -0.474040884958469 0.302803182785574 no 2379 0.317735376159744 3232 1180859 SGTC_906 1165-0455 526 µM -0.475534303567316 0.302237624250457 no 2380 0.317203094436455 3266 3252859 SGTC_1638 st008370 60.6 µM -0.475744565189367 0.302158036128421 no 2381 0.317128183671526 3316 24207134 SGTC_2433 5607874 27.82 µM -0.476633454967664 0.30182167802724 no 2382 0.316811578114786 3237 2252428 SGTC_580 1123-0028 41 µM -0.476991880318807 0.301686096609736 no 2383 0.316683951782504 3315 1677248 YPR107C YTH1 SGTC_493 zm226600 134 µM -0.477141049856506 0.301629678378917 no 2384 0.316630842657665 3388 5240098 A potassium channel opener. YCR052W RSC6 SGTC_3092 9117248 49.47 µM -0.477285528901135 0.30157503868961 no 2385 0.316579407101808 3319 17141857 SGTC_3241 9133421 49.47 µM -0.477745796541597 0.301401002442807 no 2386 0.316415572236238 3300 17018221 SGTC_2552 juarezic acid 87.02 µM -0.480840994216098 0.300231823546128 no 2387 0.315314756093136 3283 1549512 SGTC_889 0919-1524 82.7 µM -0.480892990576757 0.30021219998108 no 2388 0.315296277394136 3305 3905452 SGTC_1766 st045414 44.774 µM -0.481682849479129 0.299914176467623 no 2389 0.315015630649834 3283 253960 SGTC_2619 obliquin 87.91 µM -0.48284518600247 0.299475856241947 no 2390 0.314602832127444 3266 6708593 A bioactive alkalod. YER133W GLC7 SGTC_1027 k015-0025 8.67 µM -0.488723546225684 0.297263572982597 no 2391 0.312518715697123 3279 3598955 SGTC_3112 9123419 49.47 µM -0.489252749543173 0.297064777651915 no 2392 0.312331384257083 3350 17015854 SGTC_2505 galangin 7.89 µM -0.489930871288448 0.296810129989993 no 2393 0.312091408424923 3190 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1898 st060199 18.6 µM -0.491765144233032 0.296121826654738 no 2394 0.311442689882678 3265 688866 SGTC_2998 9066762 71.4286 µM -0.491821408174607 0.296100725425621 no 2395 0.311422800520716 3437 4945196 SGTC_2606 farnesol 9.78 µM -0.492368653691998 0.29589552246645 no 2396 0.311229377377126 3408 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_548 1436-0017 110 µM -0.492529005455959 0.295835407063283 no 2397 0.311172711145686 3416 9677137 SGTC_2135 5326629 150.42 µM -0.496946842978 0.294181383952492 no 2398 0.309613268664147 3266 5020077 SGTC_765 1319-0117 244 µM -0.497273966695923 0.294059080049744 no 2399 0.309497933711364 3307 3487746 YGL099W LSG1 SGTC_1231 0242-0792 125 µM -0.497275532936718 0.294058494525503 no 2400 0.309497381542448 3260 3707635 SGTC_1693 xanthone 101.9 µM -0.497303053349274 0.294048206368662 no 2401 0.309487679454155 3300 7020 An insecticide. SGTC_2502 avocadyne acetate 18.59 µM -0.498146717960563 0.293732893832206 no 2402 0.309190317098095 3226 3952079 SGTC_1567 st069303 68.4 µM -0.498862960700499 0.2934653270144 no 2403 0.308937964566433 3367 5581319 SGTC_2407 paclitaxel 400 µM -0.499261102929345 0.29331664184987 no 2404 0.308797726801031 3411 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2711 st079103 59.1 µM -0.50008596083878 0.293008711983473 no 2405 0.308507275545597 3293 54693780 SGTC_3033 9090887 49.47 µM -0.500718060566891 0.292772842729767 no 2406 0.308284779896343 3294 19325384 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.502099855982909 0.292257530320737 no 2407 0.307798640749076 3331 91467 include heat shock SGTC_1018 4259-0013 28.1 µM -0.502556179273825 0.292087446579102 no 2408 0.307638172472182 3363 6801262 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.502913388019304 0.291954337602316 no 2409 0.307512583975413 3248 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_2992 9074591 71.4286 µM -0.503453107903577 0.291753271934168 no 2410 0.307322870475422 3395 17741321 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.504257406690325 0.291453760600491 no 2411 0.307040252178816 3344 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2383 9036125 200 µM -0.504500376074618 0.291363309898892 no 2412 0.306954898984317 3273 79580 SGTC_335 4077-0256 27.6 µM -0.504622483379347 0.291317857712902 no 2413 0.306912007618046 3333 3121989 SGTC_1258 0671-0043 57.1 µM -0.505038691048373 0.291162956972929 no 2414 0.306765830526771 3327 4298767 SGTC_872 0588-0139 234 µM -0.505633130500343 0.290941790111616 no 2415 0.306557109590115 3317 2047100 SGTC_1469 k284-2957 126 µM -0.507409048745488 0.290281510873222 no 2416 0.30593391896498 3332 23884841 SGTC_811 0416-0114 265 µM -0.508003858630318 0.290060519963655 no 2417 0.3057253185843 3386 6612453 SGTC_1749 st037932 54.2 µM -0.508675318035549 0.289811146102692 no 2418 0.305489912875834 3372 594497 SGTC_2677 mitomycin C 100 µM -0.510346141964425 0.289191054351155 no 2419 0.304904490882674 3356 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_3220 9131269 49.47 µM -0.510484519962124 0.289139726200432 no 2420 0.304856028464452 3401 17722206 SGTC_666 0272-0154 136 µM -0.510526128013085 0.289124293484071 no 2421 0.304841457259683 3329 6870312 SGTC_1024 4507-0395 26 µM -0.511612071604657 0.288721646478402 no 2422 0.304461267621615 3452 4201836 SGTC_1406 3909-7906 11.9 µM -0.513599370787463 0.287985478682941 no 2423 0.303766059793513 3378 X1406 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.515211937128333 0.28738877754032 no 2424 0.303202464184995 3283 6857784 SGTC_3299 9121982 43.1275 µM -0.516247018632907 0.287006072703987 no 2425 0.302840947412368 3319 17594604 YPL160W CDC60 SGTC_2173 5763948 167 µM -0.518001654722315 0.286357876047314 no 2426 0.302228557408382 3383 2867177 SGTC_1705 st027868 56.3335 µM -0.518016794280695 0.286352286225481 no 2427 0.302223275931522 3367 292948 SGTC_3163 9099914 49.47 µM -0.51926357569933 0.2858921279492 no 2428 0.30178847502366 3372 16268368 SGTC_2280 7785178 200 µM -0.52013797039097 0.285569618909846 no 2429 0.301483707623641 3309 2954328 SGTC_1295 1013-0063 9.78 µM -0.520382129085942 0.285479595106469 no 2430 0.301398631654799 3437 6826038 SGTC_3005 9076496 71.4286 µM -0.520747488140062 0.285344908735308 no 2431 0.30127134417068 3387 21368410 SGTC_876 0720-0963 56.8 µM -0.52144588216584 0.285087536235503 no 2432 0.301028097988795 3450 765861 SGTC_3094 9117742 49.47 µM -0.521881314891322 0.284927126388435 no 2433 0.300876484368336 3359 17149698 SGTC_3119 9125183 49.47 µM -0.521882081495208 0.284926844015815 no 2434 0.300876217474374 3269 22695334 SGTC_687 k029-0044 34.9 µM -0.521983526305779 0.284889478780904 no 2435 0.300840900297133 3409 5829338 SGTC_1997 st073024 93.8 µM -0.523530835063067 0.284319847444882 no 2436 0.300302449417979 3405 686268 SGTC_3203 9113543 49.47 µM -0.523880663701547 0.284191135869561 no 2437 0.30018077229088 3410 17018012 SGTC_2906 7926292 26.41 µM -0.524350906316188 0.284018164590235 no 2438 0.300017248000398 3420 2966319 SGTC_2528 xanthyletin 44.79 µM -0.524372870688877 0.284010086575895 no 2439 0.300009610995562 3292 65188 An natural product with antifungal activity of unknown mechanism. SGTC_2940 9060638 45.86 µM -0.525567724641604 0.283570811234193 no 2440 0.2995942933001 3361 4027022 SGTC_2168 5727979 200 µM -0.526426797543351 0.283255183524073 no 2441 0.299295850386073 3361 695210 SGTC_1962 st076595 64.5 µM -0.528242809283919 0.282588526802822 no 2442 0.298665410130081 3346 279619 SGTC_2867 9039098 71.43 µM -0.529324926575335 0.282191641196055 no 2443 0.298290033413937 3366 6463460 SGTC_1971 st069429 63.5 µM -0.530628300899997 0.281713962158445 no 2444 0.297838190029445 3404 1246522 YGL099W LSG1 SGTC_3003 9075612 71.4286 µM -0.531211598448226 0.281500313367167 no 2445 0.297636078253503 3385 6501993 SGTC_2210 7115885 190.385 µM -0.531287219384654 0.281472620841471 no 2446 0.297609880289941 3397 2927039 SGTC_787 4152-0075 138 µM -0.531788981478607 0.281288907943516 no 2447 0.297436077515851 3362 9566539 SGTC_1195 1502-0147 41.1 µM -0.532107598207432 0.281172281116331 no 2448 0.29732573758561 3400 817940 SGTC_3179 9107801 49.47 µM -0.532403641832138 0.281063937907938 no 2449 0.297223231695042 3343 4818259 SGTC_339 3091-4833 71.4 µM -0.532998521174395 0.280846290671121 no 2450 0.297017301998014 3405 3240077 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.533203276324754 0.280771396194938 no 2451 0.296946436898832 3420 616764 SGTC_400 oxethazaine 37.5 µM -0.535147144165716 0.280060857910783 no 2452 0.296274056146149 3395 4621 A local anesthetic. SGTC_342 k048-0088 23.3 µM -0.53523420525129 0.280029055042023 no 2453 0.296243958199772 3317 6820570 SGTC_2739 tacrine 100.86 µM -0.535967107135774 0.279761400001651 no 2454 0.295990641810588 3406 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_819 1013-0258 27.7 µM -0.536704033908368 0.279492400284451 no 2455 0.295736034587244 3374 5753198 SGTC_428 3448-4153 16.5 µM -0.536941249585737 0.279405836389754 no 2456 0.295654098300921 3256 3834874 SGTC_2457 5731572 11.68 µM -0.53838047917219 0.278880917265202 no 2457 0.295157200167134 3430 2865357 SGTC_2635 hydroquinidine 100 µM -0.539872244169909 0.278337344231487 no 2458 0.294642570245168 3393 442912 An experimental heart treatment. SGTC_1149 3909-7961 23.3 µM -0.54026021918045 0.278196057600843 no 2459 0.29450879426291 3386 735261 SGTC_1775 st081588 35.1725 µM -0.540684398435194 0.278041626710241 no 2460 0.294362566936689 3461 1426443 YGL099W LSG1 SGTC_2735 sertaconazole 140 nM -0.541321113141478 0.277809896602166 no 2461 0.294143135209036 3433 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_1547 harmine 94.2 µM -0.541424498559359 0.277772278738691 no 2462 0.294107512506907 3446 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_409 arachidonic acid 100 µM -0.542153896368517 0.277506950432695 no 2463 0.293856246300944 3363 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_3004 9076122 71.4286 µM -0.543785083832238 0.276914032577204 no 2464 0.293294687219745 3434 44782551 SGTC_1718 roemerine 11.9335 µM -0.544280764246039 0.276733981423358 no 2465 0.293124140898205 3413 235224 An aporphine alkaloid with mutagenic activity. SGTC_9 0092-0002 10.449 µM -0.545102824396523 0.276435502461747 no 2466 0.292841400136982 3437 759368 SGTC_1669 st015249 58.4 µM -0.547139697986993 0.275696622037639 no 2467 0.292141380430261 3487 722793 SGTC_443 clozapine 122 µM -0.547714751347811 0.275488196020451 no 2468 0.291943890813044 3395 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.550374361301347 0.274525239375712 no 2469 0.291031315099727 3372 5106787 A p450 inhibitor. SGTC_2968 9090663 33.37 µM -0.551534159391317 0.274105835549687 no 2470 0.29063377836754 3333 25236811 SGTC_2422 chlorphenesin carbamate 384.24 µM -0.553055726582174 0.273556090023217 no 2471 0.290112625882254 3354 2724 A muscle relaxant with antifungal properties. SGTC_1048 3161-0300 24.5 µM -0.553056573598607 0.27355578414637 no 2472 0.290112335892378 3450 2165101 SGTC_1782 st039423 80.636 µM -0.55327014702847 0.273478663339082 no 2473 0.290039219885056 3351 2068169 SGTC_665 3914-0008 307 µM -0.554030464722609 0.273204201995873 no 2474 0.28977899830891 3378 1069549 SGTC_2865 9030313 51.95 µM -0.554682701120634 0.272968864903972 no 2475 0.289555855288308 3325 42562754 SGTC_205 1486-1330 71.903 µM -0.555186713398493 0.272787078262467 no 2476 0.289383477963419 3430 4118834 SGTC_3031 9088762 49.47 µM -0.555355940899636 0.272726054928457 no 2477 0.289325611250499 3376 205253 SGTC_1952 st077036 64.1 µM -0.556749198475209 0.272223904692891 no 2478 0.288849398816509 3463 2937007 SGTC_2520 obtusaquinone 4.71 µM -0.557002564452941 0.272132637321403 no 2479 0.288762838533289 3530 5967872 SGTC_1896 st058441 89 µM -0.558623831413338 0.271548985642232 no 2480 0.288209236096314 3370 688759 SGTC_2959 9079155 11 µM -0.562091994928213 0.270302553106465 no 2481 0.287026671064588 3478 16189457 SGTC_784 4579-0127 173 µM -0.565998251697654 0.268902106598454 no 2482 0.285697484499148 3514 1948547 SGTC_1259 0671-0132 43 µM -0.566084375795098 0.268871271027121 no 2483 0.285668211975054 3356 X1259 SGTC_2622 2-methoxyxanthone 59.94 µM -0.567178522451035 0.268479681211511 no 2484 0.285296449232433 3413 71034 A hepatoprotective. SGTC_105 0111-0055 734.78 µM -0.567382664018121 0.268406651680466 no 2485 0.285227112727144 3440 5179370 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.568543290474533 0.267991639524188 no 2486 0.284833059638106 3416 5711223 A potent inhibitor of glutathione S-transferases. SGTC_1206 3978-0017 132 µM -0.569142618417981 0.267777460810363 no 2487 0.284629679010457 3543 3873677 SGTC_2463 5473429 200 µM -0.570553914330361 0.267273454207721 no 2488 0.284151032890339 3404 5399405 SGTC_685 1278-0033 54.9 µM -0.572330357081077 0.266639726388939 no 2489 0.283549093650286 3521 3590572 SGTC_14 0354-0009 295 µM -0.572424910285124 0.266606016804812 no 2490 0.283517071877512 3481 1713507 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.572556449651036 0.266559124703646 no 2491 0.283472527103346 3456 5355888 SGTC_2961 9083290 32.55 µM -0.574041158921487 0.266030134231003 no 2492 0.282969974709814 3471 17741490 SGTC_3333 9141820 12.094 µM -0.576128755136013 0.265287240308777 no 2493 0.282264078272189 3382 1939433 SGTC_2624 nerol 100 µM -0.576796762940075 0.265049745043474 no 2494 0.282038378278853 3440 637566 A natural product oil. SGTC_2242 6630449 61.2675 µM -0.577117985106968 0.26493558014108 no 2495 0.281929877803876 3471 691249 YDR170C SEC7 SGTC_3272 9137413 49.47 µM -0.577132798180765 0.264930316060157 no 2496 0.28192487481873 3450 17614870 SGTC_2201 6605497 169.863 µM -0.578275844676083 0.264524275164924 no 2497 0.281538949980724 3461 670741 SGTC_3007 9078383 71.4286 µM -0.57861785702082 0.264402844745088 no 2498 0.28142352648728 3411 6496995 SGTC_503 tyrphostin 8 294 µM -0.579342503142433 0.264145655170329 no 2499 0.281179045912904 3480 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_106 0092-0003 11.579 µM -0.579879886549091 0.263955010733794 no 2500 0.280997810155857 3434 1072148 SGTC_1838 st055369 84.5 µM -0.580235842342687 0.263828768956519 no 2501 0.280877793029998 3475 676036 SGTC_783 0848-0141 92.7 µM -0.580419887665896 0.263763508295833 no 2502 0.280815748441277 3477 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_880 0833-0487 87.2 µM -0.581092762576391 0.263524983562524 no 2503 0.280588968087721 3473 76075 SGTC_2034 5197015 53.07 µM -0.581255136135336 0.263467440901106 no 2504 0.280534256283444 3518 780676 SGTC_2489 cantharidin 73.42 µM -0.582360213424439 0.263075989141939 no 2505 0.280162037464496 3501 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2659 sanguinarine 24.21 µM -0.585084508241396 0.262112232750596 no 2506 0.279245447469664 3440 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_885 0865-0106 16.8 µM -0.585127590282666 0.262097006437839 no 2507 0.279230964214632 3465 2793380 SGTC_1666 st014829 29 µM -0.588137822283948 0.261034235801291 no 2508 0.278219893982354 3494 3858230 SGTC_2556 citropten 84.59 µM -0.588204633334416 0.261010673134562 no 2509 0.278197473896139 3426 2775 A potential DNA crosslinker. SGTC_1783 st039459 87.517 µM -0.588848904916024 0.260783510019863 no 2510 0.277981317992316 3549 729761 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.590409658926449 0.260233627208048 no 2511 0.277458018271944 3534 7104 SGTC_423 5-fluorouracil 457 µM -0.591644790309708 0.259798891247782 no 2512 0.277044237018061 3454 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_3196 9111891 49.47 µM -0.592447899294525 0.259516417760559 no 2513 0.276775349689495 3520 18891510 SGTC_2832 7992762 51.95 µM -0.592658706274846 0.259442297969407 no 2514 0.276704791010706 3309 2985177 SGTC_1013 4112-3890 241 µM -0.592957203569153 0.259337364946397 no 2515 0.276604896803588 3391 705171 SGTC_2734 clemastine 41.6 µM -0.593623315712582 0.259103280573097 no 2516 0.276382041470897 3442 26987 Clemastine is a selective histamine H1 antagonist. SGTC_3290 9121031 71.43 µM -0.594082101791437 0.258942118046569 no 2517 0.276228600646551 3439 17014854 SGTC_1845 st056753 3.01 µM -0.594943114939715 0.258639801095716 no 2518 0.275940748029925 3435 5375839 SGTC_2090 5301565 104.445 µM -0.595265011905625 0.258526824323522 no 2519 0.275833169773062 3516 2056344 SGTC_1868 st057644 42.7 µM -0.595869660165173 0.25831467892266 no 2520 0.275631151504675 3453 688665 SGTC_508 roscovitine 141 µM -0.597393032336416 0.257780592555855 no 2521 0.275122502290102 3511 160355 A CDKinase inhibitor. SGTC_1819 st053448 58.6 µM -0.598160036694545 0.257511901911026 no 2522 0.274866577006275 3447 2857616 SGTC_2561 acetosyringone 100 µM -0.598533612627314 0.257381086571232 no 2523 0.274741968946897 3441 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_949 1165-0505 146 µM -0.601207244918761 0.25644586783661 no 2524 0.273850979800408 3492 6244267 SGTC_2184 6075246 200 µM -0.601243719655792 0.256433121470323 no 2525 0.273838834463393 3502 2267320 SGTC_1747 st037496 66.6 µM -0.601521086372096 0.256336204423144 no 2526 0.273746485767646 3498 723305 SGTC_190 3970-0790 3.722 µM -0.6023667734191 0.256040823653042 no 2527 0.273465011066824 3505 2832352 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.603930428156921 0.255495139815249 no 2528 0.272944948863847 3476 688664 SGTC_2414 st077232 92.9 µM -0.604302374895457 0.255365427449309 no 2529 0.272821313846362 3412 729801 SGTC_2752 diclazuril 33.15 µM -0.605076179104897 0.255095682002685 no 2530 0.272564190537121 3536 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_1416 3966-0321 25.3 µM -0.606348097818239 0.254652619613998 no 2531 0.272141812952602 3504 582530 YLR208W SEC13 SGTC_2331 7980721 200 µM -0.606720760186613 0.254522882133571 no 2532 0.272018121239228 3481 2981221 SGTC_692 k241-0027 77.8 µM -0.607554917844769 0.254232606720216 no 2533 0.271741354323151 3589 3600480 SGTC_529 4076-0302 30.3 µM -0.607948860689058 0.254095580389399 no 2534 0.271610695944975 3473 5816522 SGTC_1681 tripelennamine 100 µM -0.609153673615685 0.25367674720518 no 2535 0.271211291842472 3540 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_732 3970-1727 52.7 µM -0.609722300585897 0.253479199505734 no 2536 0.271022889695287 3538 1275699 SGTC_558 k064-0027 21.3 µM -0.610955126839637 0.253051178937989 no 2537 0.270614643940133 3519 5088526 SGTC_406 estrone 100 µM -0.613057502357483 0.252322140700065 no 2538 0.269919159478088 3565 5870 A steroid. SGTC_194 1486-1323 56.904 µM -0.613256488263195 0.25225319600221 no 2539 0.26985337955234 3512 5178754 SGTC_3043 9092303 49.47 µM -0.613279859767281 0.2522450988882 no 2540 0.269845654025295 3490 25236084 SGTC_2290 7904846 200 µM -0.613518509928514 0.252162425809116 no 2541 0.269766773773344 3524 2962154 SGTC_3338 9144300 39.5675 µM -0.613726702892726 0.252090315371628 no 2542 0.269697969870115 3489 4901274 SGTC_2589 lobaric acid 100 µM -0.614499250446568 0.251822828227755 no 2543 0.26944273411638 3490 73157 A novel microtubule depolymerizer. SGTC_1578 josamycin 24.2 µM -0.614940586948442 0.251670086995189 no 2544 0.269296978872992 3469 5282165 A P450 substrate. SGTC_3348 9149464 3.537 µM -0.616768287665703 0.251038063121235 no 2545 0.268693785968435 3547 1951442 SGTC_2312 7706453 155.7 µM -0.619448501765336 0.250112758691184 no 2546 0.267810468874195 3533 976098 SGTC_3057 9095946 49.47 µM -0.620104308213007 0.249886626991848 no 2547 0.267594557988615 3548 24540043 SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.620142385068381 0.249873500866815 no 2548 0.267582024657167 3533 23665772 A membrane-active detergent. SGTC_2424 5537928 59.2 µM -0.622006374380655 0.249231380932397 no 2549 0.2669688382702 3548 5382802 SGTC_1453 4237-0541 195 µM -0.622938056702457 0.248910757773769 no 2550 0.266662614069644 3541 739892 SGTC_1144 3486-0183 12.5 µM -0.622973572425105 0.248898539966787 no 2551 0.266650944320115 3519 6744069 SGTC_2964 9083345 53.42 µM -0.623605261003968 0.248681285348411 no 2552 0.266443427348784 3489 17741579 SGTC_1194 1488-0194 225 µM -0.625884379656556 0.247898275697945 no 2553 0.265695390394478 3532 1391452 SGTC_622 1348-1566 26.3 µM -0.627410925186706 0.247374555412689 no 2554 0.265194954050447 3544 7340407 SGTC_2161 5662504 8.5105 µM -0.627430648377996 0.247367792742061 no 2555 0.265188491473082 3521 2859334 SGTC_1380 2291-0730 164 µM -0.628030333902047 0.247162220280979 no 2556 0.264992034377536 3528 2999191 SGTC_2079 5212404 121 µM -0.628589589686339 0.246970589518981 no 2557 0.264808888734824 3579 758462 SGTC_836 0330-0104 1.35 µM -0.628841030865167 0.246884458319096 no 2558 0.26472656750135 3565 46494820 SGTC_344 k064-0035 6.43 µM -0.629031820330527 0.246819114098907 no 2559 0.264664112176631 3505 5088750 SGTC_405 ebelactone b 50 µM -0.629551026710903 0.246641335992953 no 2560 0.264494186853248 3537 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_615 k087-0205 167 µM -0.630918129322622 0.246173563424863 no 2561 0.26404702862707 3527 9642773 SGTC_328 k915-0120 63.5 µM -0.631289263070725 0.246046657174573 no 2562 0.26392570300406 3551 6624543 SGTC_2627 acetyl isogambogic acid 100 µM -0.631839362748519 0.245858619520969 no 2563 0.263745924742244 3531 6857789 A caspase activator and apoptosis inducer. SGTC_2805 7950783 58.44 µM -0.632748116759003 0.245548153993717 no 2564 0.263449071405398 3547 1178958 YDL195W SEC31 SGTC_2881 9058953 51.95 µM -0.633299948820551 0.245359729635694 no 2565 0.263268893358794 3528 17122249 SGTC_3229 9132204 49.47 µM -0.633491267835302 0.245294421453568 no 2566 0.26320644070461 3557 17682924 SGTC_3332 9141069 11.198 µM -0.634871642618691 0.244823497217077 no 2567 0.262756066553731 3549 17332883 SGTC_2361 9034121 116 µM -0.635083804882889 0.244751159788768 no 2568 0.262686879449521 3540 6496917 SGTC_1402 3909-7673 35.9 µM -0.638241212423195 0.24367599230433 no 2569 0.261658336758727 3561 5328014 SGTC_3159 9100096 49.47 µM -0.639129583916507 0.243373942398911 no 2570 0.261369317902559 3549 25236875 SGTC_50 0929-0078 56.389 µM -0.640324045029002 0.242968139882783 no 2571 0.260980975805788 3482 1377751 SGTC_451 chloral hydrate 100 µM -0.642266917835187 0.242308856956172 no 2572 0.260349945170596 3629 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_2971 9092186 9.93 µM -0.643295170609998 0.24196032847009 no 2573 0.260016294679506 3491 25236400 SGTC_1480 1070-0044 41.2 µM -0.644053166631169 0.241703578306007 no 2574 0.259770479150728 3567 3124987 SGTC_1174 0739-0097 51.1 µM -0.646069396076333 0.241021356839592 no 2575 0.259117207024813 3602 728447 SGTC_2817 7995342 71.43 µM -0.648180000271983 0.24030832554152 no 2576 0.258434267914296 3522 18879975 SGTC_3276 9139060 49.47 µM -0.650848491601215 0.239408469231933 no 2577 0.257572147059264 3648 4870619 SGTC_1731 st035964 63 µM -0.652651020944263 0.238801671536344 no 2578 0.256990642585957 3560 6739575 SGTC_1866 st057638 64 µM -0.652702493172604 0.238784356454057 no 2579 0.256974047437371 3590 688802 SGTC_2193 5925765 200 µM -0.652902814701142 0.238716975512399 no 2580 0.256909467129557 3601 877370 SGTC_2294 7971431 200 µM -0.656027296489822 0.237667360174753 no 2581 0.25590328065028 3550 5741572 SGTC_17 0960-0276 49.807 µM -0.658565103278081 0.236816695087044 no 2582 0.255087539012053 3620 6821114 SGTC_2402 5553605 200 µM -0.658837277559543 0.236725562611633 no 2583 0.255000133317317 3645 6758546 SGTC_1752 st044819 83.042 µM -0.660021552620515 0.236329254871427 no 2584 0.254619999264722 3547 441209 YML126C ERG13 SGTC_165 k038-0023 64.381 µM -0.660380804570886 0.236209106465994 no 2585 0.254504743624511 3601 46368543 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.660512524007333 0.236165062580588 no 2586 0.254462492086858 3612 115019 SGTC_457 grayanotoxin iii 135 µM -0.662163591374301 0.235613368334989 no 2587 0.253933192479824 3579 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_1850 st056238 17 µM -0.66230530391473 0.235566049091051 no 2588 0.253887789175851 3625 5393177 SGTC_1401 3807-4679 7.6 µM -0.663971472291229 0.235010092069516 no 2589 0.253354284932212 3609 3291456 SGTC_947 3447-0010 211 µM -0.664579301573086 0.234807455867513 no 2590 0.253159805848315 3638 748350 SGTC_2199 6590217 200 µM -0.666324017033579 0.23422634499373 no 2591 0.252602008789615 3573 703109 SGTC_1068 loratadine 26.9 µM -0.66767600609371 0.233776587238997 no 2592 0.252170214591381 3617 3957 A H1 histamine antagonist. SGTC_1564 D-Arginine 115 µM -0.669624263457015 0.233129315340352 no 2593 0.251548671358838 3589 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_1821 st053465 65.6 µM -0.670103873674431 0.23297012660846 no 2594 0.251395787849687 3594 675086 SGTC_1156 4092-0367 4.88 µM -0.670425634065509 0.232863364088257 no 2595 0.251293249057665 3622 1357585 SGTC_1120 ficusin 1.78878 µM -0.670947222916772 0.232690354739058 no 2596 0.251127075801792 3663 6199 A DNA cross-linker. SGTC_3277 9138724 49.47 µM -0.671380964470717 0.232546538481045 no 2597 0.250988934138936 3559 15943418 SGTC_3146 9095609 49.47 µM -0.672943639610027 0.23202881022569 no 2598 0.250491573798045 3649 17173999 SGTC_356 1634-0012 32.5 µM -0.674166697647695 0.231624048249075 no 2599 0.250102669715073 3635 735457 SGTC_275 trichlorophene 5.69 µM -0.674716615093983 0.231442185479192 no 2600 0.249927913166335 3667 62616 SGTC_1170 0310-0127 64.8 µM -0.67706085629898 0.230667817107896 no 2601 0.249183671651062 3624 774975 SGTC_2783 7738165 71.43 µM -0.678497786441264 0.230193875416763 no 2602 0.24872806342477 3582 17201110 SGTC_303 1348-1668 34.2 µM -0.678888580158743 0.230065074468614 no 2603 0.248604231018533 3647 5380509 SGTC_2937 9044753 11.33 µM -0.679241623661962 0.229948750219987 no 2604 0.248492388919599 3653 6465530 YGL099W LSG1 SGTC_2803 7707263 71.43 µM -0.679272925574302 0.22993843814681 no 2605 0.248482473952566 3632 2199229 SGTC_2142 5622915 118.518 µM -0.680745395781264 0.229453641497857 no 2606 0.248016303254793 3632 5322196 SGTC_1339 1486-1321 22.7 µM -0.680750814530655 0.229451858485282 no 2607 0.248014588590139 3670 3469382 SGTC_2823 7987624 58.44 µM -0.683029903836797 0.228702624238574 no 2608 0.247293973358844 3680 2239440 SGTC_196 k015-0023 18.111 µM -0.683461362625048 0.228560940061192 no 2609 0.247157678425819 3646 5211998 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.684707115288059 0.228152131580895 no 2610 0.246764379092541 3689 368090 SGTC_1743 st037606 46.3785 µM -0.684845457908959 0.228106758189876 no 2611 0.246720723318527 3672 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_2729 fluphenazine 10.66 µM -0.684853475638898 0.228104128703236 no 2612 0.246718193348634 3598 3372 An atypical antipsychotic. SGTC_2464 5717415 7.67 µM -0.686744216892229 0.227484519259489 no 2613 0.246121963891705 3601 5285744 SGTC_3204 9114183 49.47 µM -0.689397265682144 0.226616696594882 no 2614 0.245286651827767 3675 17027248 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.692241453163579 0.225688430706045 no 2615 0.244392855160823 3799 16725076 SGTC_806 3966-4455 5.86 µM -0.692639269566404 0.225558765894262 no 2616 0.244267979911224 3618 714982 SGTC_2094 5332512 191.667 µM -0.692967504436893 0.225451812331819 no 2617 0.244164972327014 3693 755774 SGTC_1769 st044406 64.4 µM -0.693621518281741 0.225238791061142 no 2618 0.243959797724025 3670 670903 SGTC_2223 6903751 107.57 µM -0.69374520357592 0.225198517888309 no 2619 0.243921006130818 3630 5598863 SGTC_2477 5967686 25.23 µM -0.694184384839496 0.22505554902258 no 2620 0.243783291985818 3676 776118 SGTC_1627 st003713 25.6 µM -0.69419717715735 0.225051385446593 no 2621 0.243779281325604 3708 16195070 YER133W GLC7 SGTC_1662 st014054 52 µM -0.694231744820223 0.225040134764762 no 2622 0.243768443815723 3672 2838777 SGTC_902 1120-0002 2.07 µM -0.69619289146609 0.224402365695719 no 2623 0.243154019409378 3661 3280475 SGTC_2282 7944268 200 µM -0.698131337065747 0.223772988398506 no 2624 0.242547531026918 3699 2970414 SGTC_654 1124-0271 80.9 µM -0.699158477860398 0.223439901989225 no 2625 0.242226498199308 3677 5403748 SGTC_3082 9117008 49.47 µM -0.700112757952655 0.223130696143783 no 2626 0.241928444498414 3714 41448529 SGTC_1223 0764-0573 147 µM -0.700283382516185 0.223075436056357 no 2627 0.241875173694865 3688 1609797 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.700613611763698 0.222968507024311 no 2628 0.241772090691809 3646 2724278 An inhibitor of dopamine biosynthesis. SGTC_1827 berberine 7.24 µM -0.701438839636402 0.222701423908348 no 2629 0.241514595222421 3621 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_480 am 92016 50 µM -0.701569551382597 0.222659136085284 no 2630 0.241473822964945 3608 2129 K+ channel blocker. SGTC_68 0986-0284 82.829 µM -0.704000814451386 0.22187340941309 no 2631 0.240716133201982 3676 423278 YIL048W NEO1 SGTC_2649 anisomycin 9.56 µM -0.704395014830055 0.221746162540687 no 2632 0.240593404840815 3662 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_3254 9136651 49.47 µM -0.704411967780002 0.221740691107094 no 2633 0.240588127558858 3679 16454030 SGTC_2238 6671620 73.2395 µM -0.704473118980732 0.22172095567049 no 2634 0.240569092331842 3645 729941 SGTC_3076 9116187 49.47 µM -0.705166535261156 0.221497238411875 no 2635 0.240353302167429 3649 27241210 SGTC_931 2812-0076 566 µM -0.706059338601546 0.221209382921702 no 2636 0.240075618390044 3714 3450959 SGTC_60 0986-0278 202 µM -0.707311650084946 0.220805976523622 no 2637 0.239686413642091 3522 3110598 SGTC_1864 st057645 30.4 µM -0.709057661960932 0.220244238411266 no 2638 0.239144347412839 3716 688666 SGTC_2733 amorolfine 100 µM -0.709861655579452 0.219985848231979 no 2639 0.238894965307035 3701 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_3103 9120822 49.47 µM -0.70993008763666 0.219963863341867 no 2640 0.238873745675269 3747 17141819 SGTC_952 1185-0122 232 µM -0.709940075108034 0.21996065481278 no 2641 0.238870648814318 3662 678600 SGTC_1628 st004252 77.7 µM -0.710060863705418 0.21992185295032 no 2642 0.238833197079902 3679 692968 SGTC_1776 st049249 45.9 µM -0.71045060937701 0.219796678698966 no 2643 0.238712374370413 3719 1822314 SGTC_1981 st071826 47 µM -0.710905375788894 0.219650673511565 no 2644 0.238571437260117 3667 11838600 SGTC_2705 st078069 42.8 µM -0.711325667087442 0.219515786277741 no 2645 0.238441224873627 3690 1530061 SGTC_145 3737-0113 38.366 µM -0.712777462978157 0.219050216767923 no 2646 0.237991736799455 3716 6849351 SGTC_805 3852-0218 479 µM -0.71363829470636 0.2187744291224 no 2647 0.237725435663075 3658 6615355 SGTC_2882 9058044 58.44 µM -0.716210745446417 0.21795147589072 no 2648 0.236930614516763 3647 18076804 SGTC_3245 9134821 49.47 µM -0.717007294794649 0.21769701401651 no 2649 0.236684797778019 3688 17014901 SGTC_1457 k015-0032 57.3 µM -0.717945232921968 0.217397604613844 no 2650 0.236395528116212 3700 4302660 SGTC_476 mead acid 10 µM -0.719748679766127 0.216822575363827 no 2651 0.235839874029643 3723 5312531 An omega 9 fatty acid. SGTC_857 0438-0306 1.35 µM -0.721448878559009 0.216281272971088 no 2652 0.23531669141598 3747 4686136 SGTC_2202 7226349 200 µM -0.721461595447768 0.216277227169591 no 2653 0.235312780609667 3663 844334 SGTC_88 0180-0332 8.668 µM -0.722984041941233 0.215793186691452 no 2654 0.234844844215972 3772 3101745 SGTC_930 2810-3379 265 µM -0.723423263078253 0.215653659290231 no 2655 0.234709941659125 3743 1015764 SGTC_2895 9054447 58.44 µM -0.723632477822322 0.215587216427631 no 2656 0.234645698426829 3746 2697450 SGTC_2447 5741742 33.78 µM -0.72368914165539 0.215569223050396 no 2657 0.23462830042912 3757 1776504 SGTC_381 3461-2219 42.7 µM -0.724217154295114 0.215401596587421 no 2658 0.234466214340823 3693 2883159 SGTC_2131 toluylene red 5.2905 µM -0.725057852715825 0.21513485889394 no 2659 0.234208269776036 3725 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_704 1310-0270 142 µM -0.726333503338687 0.214730485540371 no 2660 0.233817172645033 3688 5718033 SGTC_326 k292-0812 17.5 µM -0.728825859622936 0.213941699724894 no 2661 0.233054095533773 3689 3579357 SGTC_769 0302-0231 76 µM -0.72949489999675 0.21373024804599 no 2662 0.232849493163958 3717 571869 YER009W NTF2 SGTC_2813 7971799 71.43 µM -0.732458616122261 0.212795024200136 no 2663 0.231944346496856 3775 2234054 SGTC_1369 1866-0067 208 µM -0.733515186483167 0.212462193643016 no 2664 0.231622134411313 3736 3531355 SGTC_2710 st078562 53.7235 µM -0.733740476666309 0.212391264270834 no 2665 0.231553462116347 3708 17250908 SGTC_1493 4348-0038 111 µM -0.733828578634168 0.212363530397849 no 2666 0.231526610219367 3754 800424 SGTC_623 k072-0108 16.9 µM -0.736404187750577 0.211553682635868 no 2667 0.230742378429869 3735 5382803 SGTC_3199 9111318 49.47 µM -0.736593035874408 0.211494374427559 no 2668 0.230684935640906 3698 8548020 SGTC_600 1495-0418 41.6 µM -0.740201771974534 0.210362913998266 no 2669 0.229588786280221 3748 5377768 SGTC_1816 st051957 91.6 µM -0.740826184142673 0.210167501015417 no 2670 0.22939941838477 3735 674121 SGTC_2017 5132927 60.65 µM -0.740961663820666 0.210125116038185 no 2671 0.229358342499578 3750 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_2059 5238311 157 µM -0.74146170902444 0.20996871978089 no 2672 0.229206770223359 3742 703021 SGTC_450 aminopyrene 156 nM -0.741901457876071 0.209831238613299 no 2673 0.229073521237826 3692 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_1418 3966-3099 2.4 µM -0.742039630283618 0.209788051920882 no 2674 0.229031662374698 3728 740335 SGTC_364 0083-0097 67.7 µM -0.743405809718398 0.209361324918257 no 2675 0.228618013989497 3804 5207356 SGTC_3078 9116413 49.47 µM -0.743408780717046 0.209360397481939 no 2676 0.228617114895413 3681 17177322 SGTC_401 neomycin 50 µM -0.745734891000405 0.208635013788545 no 2677 0.227913788901734 3747 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_1275 0867-0008 21.1 µM -0.74586704704971 0.2085938462339 no 2678 0.227873866590763 3739 3422836 SGTC_438 sphingosine 6.67 µM -0.746476923061325 0.208403927546497 no 2679 0.227689683407948 3701 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_1734 st037168 69.4 µM -0.747055081619963 0.208223980047086 no 2680 0.2275151563336 3813 708907 SGTC_589 1227-0070 34.1 µM -0.747847434627031 0.207977515113155 no 2681 0.227276093415694 3761 2841384 SGTC_2010 4012422 159 µM -0.749902401977995 0.207339111475881 no 2682 0.226656743870245 3756 952393 SGTC_1254 0550-0035 264 µM -0.750296306221842 0.207216872215451 no 2683 0.226538133397316 3817 15121435 SGTC_609 0986-0026 86.3 µM -0.751215361568897 0.20693182999399 no 2684 0.226261528358451 3737 2848610 SGTC_1209 2323-2347 50.3 µM -0.752628674056942 0.206493948501918 no 2685 0.225836540933297 3711 5412760 SGTC_1657 st012939 43.4 µM -0.753983686155573 0.206074645869861 no 2686 0.225429508856395 3762 24207257 SGTC_2041 5107442 45.335 µM -0.75528288959033 0.205673087494268 no 2687 0.225039631448848 3760 793005 SGTC_1692 fluoroquinolonic acid 71 µM -0.755645770901538 0.205561011007271 no 2688 0.224930802856008 3791 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_2218 6965428 192.983 µM -0.758365680200383 0.204722117583051 no 2689 0.224116048785558 3698 675684 SGTC_1812 st052057 4.327 µM -0.759739895331217 0.204299048047479 no 2690 0.223705038228959 3781 3645418 SGTC_487 nimodipine 119 µM -0.761461242854127 0.203769844469129 no 2691 0.223190809837289 3659 4497 L-type voltage-gated calcium channels inhibitor SGTC_560 2332-1943 155 µM -0.763327732913424 0.20319694332559 no 2692 0.222633983337488 3748 21177716 SGTC_3234 9132280 49.47 µM -0.767416036259835 0.201945442141112 no 2693 0.221417098511682 3816 17612295 SGTC_29 0299-0004 12.984 µM -0.76845527810769 0.201628049078157 no 2694 0.221108375153358 3669 16871 A napthoquinone isolated from Swertia calycina. SGTC_7 0192-1582 4.227 µM -0.768484135936913 0.201619239924435 no 2695 0.221099805991276 3822 252616 SGTC_2472 5377652 49.4 µM -0.769964337690817 0.201167702151566 no 2696 0.220660523741729 3851 1610903 SGTC_1865 st057639 52.2 µM -0.770051467589037 0.201141141956569 no 2697 0.220634681628168 3776 688818 SGTC_2706 st078239 82.5 µM -0.770143889979646 0.20111297072613 no 2698 0.220607271693656 3780 15434492 SGTC_843 0310-0051 143 µM -0.770480632804001 0.201010348305024 no 2699 0.220507419554694 3811 2065037 SGTC_992 3909-8734 162 µM -0.771383121074265 0.200735469832555 no 2700 0.220239938385914 3806 4288319 SGTC_656 4090-1979 187 µM -0.772671220439157 0.200343533596137 no 2701 0.219858491539546 3790 22330961 SGTC_2418 pentamidine 31.67 µM -0.773549011743646 0.200076707374736 no 2702 0.21959876723553 3762 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_3122 9126309 49.47 µM -0.774450101887361 0.199803021224499 no 2703 0.219332332558993 3826 17591206 SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.775178913256234 0.199581825743214 no 2704 0.219116973292037 3818 165506 SGTC_3221 9128209 49.47 µM -0.776214614957523 0.199267742165473 no 2705 0.218811139080639 3835 16460723 SGTC_2011 4012611 177 µM -0.776641174961465 0.199138471537993 no 2706 0.218685250860434 3826 2049887 SGTC_1663 st014140 55.4 µM -0.776690047240379 0.199123663834751 no 2707 0.218670830125838 3857 4207120 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.776800719765984 0.199090133863943 no 2708 0.218638176026813 3881 4213774 SGTC_729 4092-0585 94.1 µM -0.777458306801438 0.198890977757082 no 2709 0.21844421185744 3789 2169061 SGTC_3184 9108758 49.47 µM -0.779983002045358 0.198127467471365 no 2710 0.217700440202443 3801 902885 SGTC_770 0389-1121 67.2 µM -0.780433301164348 0.197991475647324 no 2711 0.217567936424953 3934 6753108 SGTC_2340 7987427 183.45 µM -0.780494854737921 0.197972890645163 no 2712 0.217549827456886 3804 2239331 SGTC_87 0100-0052 35.5 µM -0.78060249938599 0.19794039179889 no 2713 0.217518160655585 3870 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_1857 st056007 79.3 µM -0.780727718938734 0.197902590992367 no 2714 0.217481327033239 3796 619834 SGTC_2051 5263410 176 µM -0.782235701350911 0.197447709495916 no 2715 0.217038033353765 3847 227584 SGTC_2715 st079500 56.4 µM -0.782689773273726 0.197310863066563 no 2716 0.216904654566929 3748 28246688 SGTC_929 2805-0021 398 µM -0.783541847923339 0.1970542230081 no 2717 0.216654494643116 3886 3098024 SGTC_1246 0422-0085 105 µM -0.783596257967372 0.197037841876089 no 2718 0.216638526111587 3815 264295 SGTC_2841 9004761 38.96 µM -0.786142514974489 0.196272167032491 no 2719 0.215891999618839 3802 2991039 SGTC_46 0329-0187a 2.197 µM -0.787876973401246 0.195751639289376 no 2720 0.215384335651009 3877 46494817 SGTC_377 3970-0964 33.1 µM -0.789283272218374 0.195330211143466 no 2721 0.2149732306288 3795 16481235 SGTC_691 1548-0686 185 µM -0.790168034836532 0.195065355412238 no 2722 0.214714820613113 3834 46495133 SGTC_2887 9044784 58.44 µM -0.79121494680835 0.194752242044509 no 2723 0.214409285391518 3818 6465546 SGTC_950 1165-0508 94.1 µM -0.792298333597062 0.194428541791844 no 2724 0.214093371560812 3833 6148369 SGTC_1383 3049-0032 20.7 µM -0.793433136869129 0.194089830476975 no 2725 0.213762755423586 3875 712864 SGTC_674 0498-0004 451 µM -0.793773455366878 0.193988323747964 no 2726 0.213663664256463 3832 4231473 SGTC_1649 st011737 51.3 µM -0.794559975101632 0.193753852467845 no 2727 0.213434754262796 3824 1761035 SGTC_2163 5671233 125 µM -0.796603686050661 0.193145405146182 no 2728 0.212840617991921 3830 701023 SGTC_1617 st002906 78 µM -0.800354059489058 0.192031894011579 no 2729 0.211752845067088 3838 5150859 SGTC_2027 5150920 200 µM -0.800788441264174 0.191903177478011 no 2730 0.211627065851327 3807 786715 SGTC_653 0203-0016 55.2 µM -0.801010009585423 0.191837542429297 no 2731 0.211562925564161 3870 295302 SGTC_15 0266-0086 27.098 µM -0.801194278045229 0.191782967164864 no 2732 0.211509591626437 3909 1712902 YIL048W NEO1 SGTC_2731 amoxapine 43.43 µM -0.802704973258386 0.191335899202186 no 2733 0.21107263887816 3883 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_816 0325-0417 81.3 µM -0.80281389929055 0.191303688856352 no 2734 0.211041153628915 3870 68101 SGTC_2428 5615643 7.78 µM -0.80479911908028 0.190717225050944 no 2735 0.210467805051745 3877 2253075 SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.805356133715188 0.190552872977614 no 2736 0.210307098830711 3902 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_1447 4239-0816 81.9 µM -0.808191760002285 0.189717545259793 no 2737 0.209490100253413 3840 1341554 SGTC_748 act1.228 77.9 µM -0.810359111753174 0.189080601009067 no 2738 0.208866905333035 3794 4421505 YNR035C ARC35 SGTC_1807 st050092 58.9 µM -0.810478679209797 0.189045500739678 no 2739 0.208832557024473 3872 5008496 SGTC_744 1594-0068 283 µM -0.813874272607628 0.18805036503272 no 2740 0.207858490306933 3869 668392 SGTC_1210 3013-0140 750 nM -0.814429685219068 0.187887900281869 no 2741 0.207699419246771 3892 905973 SGTC_605 1315-0399 119 µM -0.815328473096703 0.187625177882095 no 2742 0.207442157367491 3939 24020461 SGTC_140 0062-0056 502.533 µM -0.816030591274217 0.187420101489881 no 2743 0.207241319762888 3811 3758964 SGTC_755 1995-0008 37.3 µM -0.818815141779614 0.1866081483165 no 2744 0.206445945297703 3831 689533 SGTC_2796 7949634 45.45 µM -0.819586960674943 0.186383478048852 no 2745 0.206225804747169 3827 2971588 SGTC_3141 9094609 49.47 µM -0.819929551470414 0.18628380634554 no 2746 0.206128134558142 3830 25236309 YDL196W YDL196W SGTC_2682 pyrogallin 40.03 µM -0.821770049733918 0.185748906203812 no 2747 0.20560389128804 3881 822798 An ATP competetive kinase inhibitor. SGTC_97 0535-0701 19.132 µM -0.822730866170426 0.18547004504968 no 2748 0.205330529288007 3779 2832013 YGL099W LSG1 SGTC_624 k048-0052 28 µM -0.822760285445141 0.185461510691535 no 2749 0.205322162614395 3852 6835531 SGTC_917 harmaline 728.087 nM -0.827074094895703 0.184212739301317 no 2750 0.20409753303915 3877 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_54 0159-0055 9 µM -0.827205932356121 0.184174657285512 no 2751 0.204060174893822 3850 3319099 SGTC_345 1362-0200 395 µM -0.828205130642877 0.183886192382861 no 2752 0.203777169353531 3874 1419823 SGTC_1940 st075990 51.1 µM -0.828676997096967 0.183750064129023 no 2753 0.203643602760852 3958 1084979 SGTC_3170 9103054 49.47 µM -0.829539529722028 0.183501395313817 no 2754 0.203399589108687 3898 16432970 SGTC_527 4476-4215 268 µM -0.829794997862619 0.183427783935612 no 2755 0.20332734973139 3870 4418754 SGTC_259 usnic acid 108.925 µM -0.830463640021669 0.183235206479136 no 2756 0.203138348572708 3924 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_158 k038-0087 26.446 µM -0.831023470741326 0.183074065122653 no 2757 0.202980185202569 3810 X158 SGTC_2952 9073731 13.78 µM -0.831820765832343 0.182844724822254 no 2758 0.202755060394327 3933 16457353 SGTC_2254 7938975 95.19 µM -0.835555036206959 0.181772958048885 no 2759 0.201702636491312 3947 2969277 SGTC_1881 5652484 16 µM -0.835883989918643 0.181678734307602 no 2760 0.201610085017806 3831 2255129 SGTC_1441 4106-0040 13 µM -0.836295131217322 0.181561012169758 no 2761 0.201494445755737 3854 2904180 SGTC_2680 butyl paraben 22.24 µM -0.838272512636086 0.180995495499023 no 2762 0.200938834954436 3937 7184 An antifungal and steroid mimetic. SGTC_1155 4088-0394 48.2 µM -0.838762279103402 0.180855596585513 no 2763 0.200801361006112 3867 2326248 SGTC_3138 9097216 49.47 µM -0.839649064393854 0.180602464091762 no 2764 0.200552590385947 3878 25237486 SGTC_2298 7976326 193.81 µM -0.840935847242561 0.180235547797786 no 2765 0.200191937411094 3760 2235818 SGTC_2675 theaflavin digallate 100 µM -0.841792886707155 0.179991429300513 no 2766 0.199951947130239 3849 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_2958 9077254 16.72 µM -0.842748164721621 0.179719573414317 no 2767 0.199684651827702 3947 16457351 SGTC_706 4262-0057 46.9 µM -0.842751559833139 0.179718607683581 no 2768 0.199683702228798 3874 883298 SGTC_834 0312-0008 75.7 µM -0.84347484788484 0.179512944596791 no 2769 0.199481463448939 3885 6385573 YIL048W NEO1 SGTC_1012 4112-3522 18 µM -0.84451174672259 0.179218366128715 no 2770 0.199191751033041 3892 3112398 SGTC_1490 4089-0339 670 nM -0.844540950916601 0.179210073748231 no 2771 0.199183594971327 3825 742542 SGTC_3035 9091303 49.47 µM -0.844884907328125 0.179112427255587 no 2772 0.199087550969605 3926 25237002 SGTC_2244 6635614 200 µM -0.845264737151987 0.179004635482813 no 2773 0.198981522349575 3819 836499 SGTC_316 k060-0003 58.6 µM -0.846573903152593 0.178633420610336 no 2774 0.198616332530349 3888 6152314 SGTC_2203 7227154 166.4 µM -0.846905449117874 0.178539487519005 no 2775 0.198523912486083 3883 896304 SGTC_878 0828-0289 13.7 µM -0.846928633693442 0.178532920064848 no 2776 0.198517450643927 3863 745350 YLR208W SEC13 SGTC_3142 9086498 49.47 µM -0.848894792938633 0.17797652324584 no 2777 0.197969918274736 3843 25236367 SGTC_2765 myclobutanil 7.74 µM -0.849012636490798 0.177943209861812 no 2778 0.197937130419573 3939 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_735 3076-0345 636 µM -0.849037814919598 0.177936092640994 no 2779 0.197930125398571 3963 2888990 SGTC_2868 9035608 32.47 µM -0.849755286604755 0.177733359387707 no 2780 0.197730576822802 3869 6462614 SGTC_584 0986-0246 15.4 µM -0.849768422131869 0.177729649090568 no 2781 0.197726924605676 3995 53315 YDR232W HEM1 SGTC_1202 1988-0068 29.6 µM -0.849883286912476 0.177697206150555 no 2782 0.197694989206363 3855 2850480 SGTC_2655 perillic acid 100 µM -0.853634768149339 0.176639674858149 no 2783 0.196653693984597 3941 5702197 An apoptosis inducer. SGTC_801 0866-0028 10.1 µM -0.853652781919482 0.176634606450292 no 2784 0.196648701947348 3896 6849771 SGTC_2908 7930301 100 µM -0.854314884914041 0.176448378996517 no 2785 0.19646527098078 3909 2223178 SGTC_103 0844-0104 51.839 µM -0.855442406301833 0.176131530862239 no 2786 0.196153137866988 3881 5375804 SGTC_1943 st076331 65.2 µM -0.856479735932326 0.175840346081497 no 2787 0.195866238417481 3939 24208415 SGTC_2862 9027634 71.43 µM -0.856887782714741 0.175725888457115 no 2788 0.195753452694265 3842 5012562 SGTC_2983 9022671 12.99 µM -0.85770719347448 0.175496185327517 no 2789 0.195527083455911 3945 6405161 SGTC_728 3030-5151 22.5 µM -0.859379277297384 0.175028045460307 no 2790 0.195065649415969 3945 3125388 SGTC_2185 6113692 200 µM -0.86474084671967 0.173532295216938 no 2791 0.19359052237024 3935 874150 SGTC_551 k048-0028 34.9 µM -0.865234166180692 0.173395080686174 no 2792 0.193455138161191 3918 6836383 SGTC_1805 st050013 60.3 µM -0.865841855024312 0.173226149808968 no 2793 0.193288446390985 3871 4037144 SGTC_2894 9048625 32.47 µM -0.867166793312349 0.172858194898817 no 2794 0.192925313906419 3925 4092861 SGTC_1583 clindamycin 39.6 µM -0.873632122683728 0.171069829973223 no 2795 0.19115931339083 3904 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_2474 5321570 43.32 µM -0.874012594973926 0.170964958110022 no 2796 0.191055697359759 3948 2841384 SGTC_3038 9091290 49.47 µM -0.87443388387552 0.170848883714253 no 2797 0.190941005717628 3923 25236843 SGTC_757 1066-0008 322 µM -0.877811877944637 0.169919995643925 no 2798 0.190022908720225 3975 6842497 SGTC_2403 6032726 181.2 µM -0.880140826450494 0.169281465649482 no 2799 0.189391512328617 4002 2881040 SGTC_1930 st074634 34.3 µM -0.880215835033109 0.169260926112235 no 2800 0.189371198394472 3872 684253 YOR116C RPO31 SGTC_1822 st052468 42 µM -0.880437288584278 0.169200295006885 no 2801 0.189311231844587 3949 2873678 SGTC_1073 triclabendazole 3.09 µM -0.880498034450915 0.16918366601518 no 2802 0.189294784749745 4014 50248 An antihelmetic and likely tubulin inhibitor. SGTC_126 0417-1624 672.48 µM -0.881511727992889 0.168906325435219 no 2803 0.189020454528306 3998 41912 YDL195W SEC31 SGTC_3294 9122953 26.2835 µM -0.881561238089779 0.168892787249581 no 2804 0.189007062162781 3949 16459826 SGTC_3002 9075603 71.4286 µM -0.881861074437384 0.16881081401738 no 2805 0.188925969620302 3895 20105405 SGTC_599 1935-0052 86.5 µM -0.883640367247018 0.168324893476782 no 2806 0.188445190340766 3952 9557311 SGTC_1399 3562-5772 25 µM -0.883867239451162 0.168262999960529 no 2807 0.18838394192675 3879 23847490 SGTC_2204 7233102 200 µM -0.886659366110391 0.167502472617735 no 2808 0.18763116068739 3835 2172480 SGTC_3266 9136860 49.47 µM -0.887071490876545 0.167390404764722 no 2809 0.18752020593799 3827 4871271 YPR165W RHO1 SGTC_199 4063-0024 41.6 µM -0.887450855670461 0.167287287950725 no 2810 0.187418106876832 3961 306215 SGTC_1820 st053765 18.6 µM -0.891406137802609 0.166214624754418 no 2811 0.186355663062863 4014 3690829 SGTC_273 hydroxyurea 18.1 mM -0.892615587619568 0.165887513714232 no 2812 0.186031534380995 4032 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_100 0086-0128 49.5915 µM -0.893516780355242 0.165644045424278 no 2813 0.185790244990573 4025 93297 SGTC_1459 k035-0031 35.7 µM -0.893560636011735 0.165632203178835 no 2814 0.185778507835443 3782 3877128 YMR208W ERG12 SGTC_1080 nisoldipine 24.4 µM -0.894687426824136 0.165328126112751 no 2815 0.185477100854795 3951 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_75 0159-0059 199.013 µM -0.897298117237814 0.164624991131851 no 2816 0.184779930439828 4017 5377270 SGTC_2846 9008642 19.48 µM -0.897519047895866 0.1645655771277 no 2817 0.184721006982266 4047 2992898 SGTC_2380 9035439 200 µM -0.897621253235797 0.164538096153476 no 2818 0.184693752191725 4078 6462575 SGTC_1905 st060207 84.5 µM -0.8995919571214 0.164008794845628 no 2819 0.184168719473825 3922 1948547 SGTC_2972 9093619 59.92 µM -0.900839641199895 0.16367425746894 no 2820 0.183836793628465 3956 25236256 SGTC_2291 7917025 104.35 µM -0.901008870991613 0.163628916590569 no 2821 0.183791801537652 3908 2964612 SGTC_360 0957-0399 1.01 µM -0.901318927734259 0.163545865822755 no 2822 0.183709386443564 3990 6752301 YPR165W RHO1 SGTC_2016 5121758 140 µM -0.902839188095812 0.163139050160217 no 2823 0.183305624673828 3914 2795203 SGTC_575 k072-0246 11.9 µM -0.902984864433366 0.163100102306572 no 2824 0.183266963969281 4003 6796779 SGTC_2196 6573537 42.6665 µM -0.906518282366013 0.162157263133718 no 2825 0.182330796292794 4005 2903087 SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.9072957181047 0.161950293450084 no 2826 0.182125218955936 4070 688801 SGTC_211 3455-0679 143.504 µM -0.909736380142062 0.161301656727285 no 2827 0.181480776633787 4033 748649 SGTC_2353 9059630 146.67 µM -0.910211079480203 0.161175696502525 no 2828 0.181355601102571 4036 4779114 SGTC_2194 5927483 104.545 µM -0.910937237411338 0.160983136604011 no 2829 0.181164221990411 3987 760979 SGTC_1936 st074407 74.3 µM -0.911284690437005 0.160891053417073 no 2830 0.181072695417031 4034 809813 SGTC_321 4534-3890 65.3 µM -0.911703175925953 0.160780190620341 no 2831 0.180962495836991 3999 699746 SGTC_147 4466-0538 29.23 µM -0.912880971878708 0.160468443411353 no 2832 0.180652573054635 4060 6742687 YHR072W ERG7 SGTC_1361 1608-0041 5.61 µM -0.913187212058221 0.160387450370073 no 2833 0.180572044202321 3948 X1361 SGTC_723 4182-0001 115 µM -0.913497439010013 0.160305430166326 no 2834 0.180490489947956 4002 744821 YLR208W SEC13 SGTC_3255 9139072 49.47 µM -0.91560618723156 0.159748629591468 no 2835 0.179936742497318 3987 17646060 SGTC_3129 9127257 49.47 µM -0.915634107371305 0.15974126596688 no 2836 0.179929417962676 3978 837894 SGTC_1949 st076024 69.1 µM -0.917426342965521 0.159269048558656 no 2837 0.179459636941641 3919 2921930 SGTC_1287 0971-0001 34.6 µM -0.917709538266925 0.159194516115438 no 2838 0.179385476359277 3976 4665869 SGTC_6 0844-0013 19.835 µM -0.918040880738695 0.159107341118057 no 2839 0.179298731902811 4125 1584900 SGTC_1255 0566-0045 221 µM -0.91809445830973 0.159093247992017 no 2840 0.179284707934703 4032 2788469 SGTC_3030 9087619 49.47 µM -0.920749907394234 0.158395779348655 no 2841 0.178590506679002 4024 25236973 SGTC_2695 st077686 51.995 µM -0.92098291101804 0.158334675507194 no 2842 0.178529674555233 4035 2876092 SGTC_2988 9073640 71.4286 µM -0.923748833833149 0.157610509963998 no 2843 0.177808550180956 4070 9102229 SGTC_467 ro 31-8220 72.8 µM -0.923785452748014 0.157600937129365 no 2844 0.177799015330972 3934 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_1403 3909-7815 62.9 µM -0.924346353051881 0.157454355570136 no 2845 0.177653008158548 3950 6615483 SGTC_1768 st044301 37.178 µM -0.925502323574091 0.157152545442823 no 2846 0.177352337805493 4002 3931349 SGTC_256 clotrimazole 625 nM -0.927503409968656 0.156630985525435 no 2847 0.176832611066533 3923 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_1515 3460-0031 42.1 µM -0.927647117639197 0.156593573694563 no 2848 0.17679532406796 3926 2876596 SGTC_302 1094-0063 18.9 µM -0.930487776062386 0.15585526443909 no 2849 0.176059295153561 3973 5440289 SGTC_540 1187-0821 17.3 µM -0.931041226048516 0.155711686031657 no 2850 0.17591611959269 3957 847520 SGTC_1550 gossypolone 36.6 µM -0.933175116708208 0.155158919558946 no 2851 0.175364780069664 4022 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1319 1306-0155 43.7 µM -0.934002695585816 0.154944891247291 no 2852 0.175151251260015 4052 3122360 SGTC_961 1252-1571 372 µM -0.934181090529892 0.154898780334734 no 2853 0.175105244078065 4025 6813498 SGTC_3055 9094636 49.47 µM -0.934693412952839 0.154766407390277 no 2854 0.174973161259945 4027 25236176 SGTC_1201 1889-3372 45.9 µM -0.938700748722705 0.153733578426336 no 2855 0.173942204465085 3889 5392199 SGTC_1028 k015-0029 4.8 µM -0.938786328636948 0.153711571401701 no 2856 0.173920229752595 3965 4588309 SGTC_382 3229-0966 23.2 µM -0.939739895118088 0.153466501204231 no 2857 0.173675497929469 4042 5722370 SGTC_3068 9116768 49.47 µM -0.941096702343001 0.153118242938277 no 2858 0.173327652657674 4007 41904888 SGTC_1407 3909-7909 12.3 µM -0.94132185369187 0.153060502965389 no 2859 0.173269973444494 4000 4411780 SGTC_1606 st000094 49.2 µM -0.941324070134134 0.15305993463141 no 2860 0.173269405697656 4051 1242210 SGTC_2858 9025781 8.96 µM -0.942460253793522 0.152768781713374 no 2861 0.172978525556415 3954 4894980 YPL153C RAD53 SGTC_3090 9117696 49.47 µM -0.944635580909744 0.152212368445129 no 2862 0.17242247765761 3984 7923821 SGTC_1168 k815-0004 80.5 µM -0.944743889972292 0.152184699959097 no 2863 0.172394821982662 4014 642433 SGTC_977 1348-1378 135 µM -0.94533446700691 0.152033890704001 no 2864 0.172244073612424 4020 X977 SGTC_1739 st037196 92.5 µM -0.94780334440699 0.151404515366129 no 2865 0.171614788818875 4107 612214 SGTC_55 0767-0285 6.563 µM -0.95191610467148 0.150359927587033 no 2866 0.1705697656566 3948 3116166 SGTC_1671 st016596 74.5 µM -0.952631158149077 0.150178804480655 no 2867 0.17038849227923 4089 2829167 SGTC_394 menadione 8.33 µM -0.956944288238423 0.149089373425333 no 2868 0.169297687798784 4024 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_971 1315-0384 26.7 µM -0.956950659479316 0.149087768061265 no 2869 0.169296079814357 4064 6769120 SGTC_2233 sulbentine 40.3845 µM -0.957323872117414 0.14899374967396 no 2870 0.169201904892288 4028 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_664 1222-0054 14.9 µM -0.957933692897974 0.14884021106763 no 2871 0.169048097651593 4005 6813991 SGTC_1338 1486-1223 76 µM -0.960496250944441 0.14819617490471 no 2872 0.168402758471478 4070 3444526 SGTC_608 k048-0125 159 µM -0.960528597450873 0.148188057337641 no 2873 0.16839462266046 4090 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_1893 st059353 36.1 µM -0.961514247916998 0.147940844567774 no 2874 0.168146832522208 4048 3112488 SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.963577978102865 0.147424131286905 no 2875 0.167628776007496 3924 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_2187 6125751 200 µM -0.965678080081357 0.146899554172292 no 2876 0.167102645644467 4064 874498 SGTC_269 exalamide 29 µM -0.969445136750542 0.145961734824094 no 2877 0.166161570542523 3960 3316 A derivative of salicylamide. SGTC_2853 9015042 58.44 µM -0.970299277952844 0.145749654698361 no 2878 0.165948668548451 3963 6457456 SGTC_804 1595-0054 20.9 µM -0.971470333107041 0.14545922283647 no 2879 0.165657059720668 3990 761523 Stimulates phospholipase C. SGTC_3052 9092717 49.47 µM -0.9719682898848 0.145335843252202 no 2880 0.16553316210584 4079 25237534 SGTC_3156 9099931 49.47 µM -0.972268458470986 0.145261503999061 no 2881 0.165458505525401 4072 18111053 SGTC_2902 5787006 60.46 µM -0.97332186330807 0.145000821968829 no 2882 0.165196679789922 4017 591003 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.97477274205745 0.144642294459822 no 2883 0.164836500449849 4094 6708760 SGTC_2058 5236698 133 µM -0.975192883179613 0.144538584730342 no 2884 0.164732295838412 4052 766665 SGTC_1737 st035557 69.7 µM -0.975621080948679 0.144432937820445 no 2885 0.164626136915699 3936 5716916 SGTC_501 nsc-95397 161 µM -0.976204550497773 0.144289065329353 no 2886 0.164481554337768 4119 262093 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.982275146277634 0.142797903510859 no 2887 0.162982157655822 4014 279621 SGTC_1675 st018485 24.5 µM -0.984135396877097 0.142343050053601 no 2888 0.162524472439371 4116 3323024 SGTC_771 0250-0039 27.3 µM -0.986866618742861 0.141677011518719 no 2889 0.161854015353447 4024 3005115 SGTC_3329 9141233 27.5565 µM -0.991016681141001 0.140669019813355 no 2890 0.16083871749368 4056 4909101 YNL103W MET4 SGTC_1931 st074438 57.1 µM -0.991423106215506 0.140570567203324 no 2891 0.160739511084457 4039 2787313 SGTC_2357 9067248 200 µM -0.991776257611899 0.140485057622138 no 2892 0.16065334097564 4076 9150235 SGTC_3117 9124945 49.47 µM -0.994419645501793 0.139846127879687 no 2893 0.160009303860177 3991 17592065 SGTC_492 tmb-8 126 µM -0.996420904275806 0.139363721998602 no 2894 0.159522840127215 4018 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -1.00476979754321 0.137363433153555 no 2895 0.157503855087869 4111 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_840 0245-0196 390 µM -1.00755385653511 0.136700788335503 no 2896 0.156834345242524 4185 3827528 SGTC_818 4072-2707 53.5 µM -1.00945402034718 0.136249779751351 no 2897 0.156378471107943 4007 882871 SGTC_1157 4092-0394 27.6 µM -1.01099611471087 0.135884509104027 no 2898 0.156009144683089 4193 3659885 SGTC_2061 5245884 80.95 µM -1.01207239840155 0.13562997110346 no 2899 0.15575171926212 4064 573863 SGTC_3089 9117425 49.47 µM -1.01238773148166 0.135555457644631 no 2900 0.155676351012628 4108 9401657 SGTC_3243 9134147 49.47 µM -1.01456419605783 0.135041922250744 no 2901 0.155156806862444 4168 24282180 SGTC_3331 9141060 1.957 µM -1.01554747029125 0.134810357439063 no 2902 0.154922465151567 4066 4906567 YPR165W RHO1 SGTC_1076 itraconazole 331 nM -1.01724306176257 0.134411679496461 no 2903 0.154518907760015 4105 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_3351 9150312 21.596 µM -1.01747119393507 0.13435810150011 no 2904 0.154464664493291 4025 4904905 SGTC_1664 st014217 9.02 µM -1.01747802352139 0.134356497763285 no 2905 0.154463040808252 4151 3982782 SGTC_1041 0206-0046 107 µM -1.0210099987055 0.133528873198307 no 2906 0.153624850774317 4120 50494 SGTC_610 4215-0184 155 µM -1.02163343311656 0.133383152738779 no 2907 0.153477213855465 4132 5605015 SGTC_923 1900-2434 73.3 µM -1.02417743033032 0.132789657532147 no 2908 0.152875738509246 4063 5910570 SGTC_2256 7954252 200 µM -1.02619537044017 0.132320182702872 no 2909 0.152399751567675 4135 2972920 SGTC_2088 5278280 127.392 µM -1.02904918055398 0.131658197312869 no 2910 0.151728282481643 4186 791502 SGTC_2593 nobiletin 86.24 µM -1.02908648358558 0.131649559457252 no 2911 0.151719518539984 4135 72344 An anti-infammatory. SGTC_3040 9091894 49.47 µM -1.02939790188267 0.13157746298446 no 2912 0.151646367325017 3976 25236966 SGTC_2785 7756463 72.73 µM -1.0303691526816 0.131352783690432 no 2913 0.15141837404531 4080 2201551 SGTC_383 2324-0395 7.37 µM -1.03056914021377 0.131306553514878 no 2914 0.151371456900882 4123 3146421 SGTC_556 4058-0063 51.5 µM -1.03129337660538 0.131139229227497 no 2915 0.151201631698764 4147 6615692 SGTC_1364 1653-0028 37.6 µM -1.03194059878199 0.130989822628268 no 2916 0.151049972742088 4111 5718652 SGTC_1233 0325-0408 14.2 µM -1.03245142164468 0.130871985906988 no 2917 0.15093034676143 4167 12874 SGTC_683 panaxydol 45 µM -1.0331170227756 0.13071855485025 no 2918 0.150774568992759 4114 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_892 0929-0076 29 µM -1.03419852206904 0.130469518277701 no 2919 0.150521682468609 4103 5751038 SGTC_754 3474-0146 171 µM -1.03431928598074 0.130441730381231 no 2920 0.150493461839951 4094 24762078 SGTC_1574 spiramycin 23.7 µM -1.03446624102812 0.130407921399965 no 2921 0.150459125508754 4090 6419898 An antibiotic and protein synthesis inhibitor. SGTC_2702 st077768 96.8 µM -1.03721008741984 0.129777775642579 no 2922 0.149818978951378 4124 6484119 SGTC_626 0214-0009 33 µM -1.03738228733613 0.129738299024372 no 2923 0.149778864932042 4192 3437874 SGTC_912 3474-0017 2.18 µM -1.03775489658634 0.12965290728148 no 2924 0.149692090027673 4176 3360550 SGTC_1719 st032227 49.2 µM -1.03897469759142 0.129373634953297 no 2925 0.149408251997391 4134 3125804 SGTC_1770 st043884 66.3 µM -1.03904113600307 0.129358435919739 no 2926 0.149392802629041 4125 670149 SGTC_524 r073-0010 27.8 µM -1.03973260589029 0.129200322663599 no 2927 0.149232073818569 4064 2772106 SGTC_1037 k284-1091 78.7 µM -1.04197000958007 0.12868963055297 no 2928 0.148712791777481 4107 3334711 SGTC_2584 androsterone 48.74 µM -1.0434533413005 0.128351830045678 no 2929 0.148369189899779 4078 2754130 A steroid. SGTC_1317 1273-0028 910 nM -1.04476236451246 0.128054236753467 no 2930 0.148066406600023 4126 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_1129 3453-1384 223 µM -1.0454522996342 0.127897579961514 no 2931 0.147906987853291 4235 1084452 SGTC_2366 9070441 60.58 µM -1.04570493499498 0.127840249854201 no 2932 0.147848641822519 4125 6837235 SGTC_3046 9092212 49.47 µM -1.0463667485758 0.127690150314906 no 2933 0.147695869321454 4197 25236637 SGTC_1902 st060212 70.5 µM -1.0471196289943 0.127519545788001 no 2934 0.147522203614686 4141 688944 SGTC_2984 9022109 38.96 µM -1.04846026089762 0.127216147882134 no 2935 0.147213301038056 4161 6459207 SGTC_2084 5306078 60.6385 µM -1.04891389688096 0.127113599501853 no 2936 0.147108874457033 4061 679340 SGTC_1622 st003707 19.4 µM -1.05069739409603 0.12671098206417 no 2937 0.146698796624562 4154 10140899 SGTC_1565 sinapyl alcohol 95.1 µM -1.05271715928931 0.126256101355371 no 2938 0.146235320937009 4185 5280507 A phenol propionate derived from cinnamic acid. SGTC_1141 3253-0389 52.6 µM -1.05360798345075 0.126055836810195 no 2939 0.146031216292039 4150 5402031 SGTC_901 1112-0062 60.1 µM -1.0538831604693 0.125994019565455 no 2940 0.14596820674871 4171 1908457 SGTC_2929 9013348 24.6 µM -1.05494522297989 0.125755630373477 no 2941 0.145725188900648 4138 2995952 SGTC_1274 0865-0114 173 µM -1.05499036851306 0.125745504041033 no 2942 0.145714864869658 4142 870624 SGTC_3113 9123498 49.47 µM -1.05609570174341 0.125497750600155 no 2943 0.145462246972919 4238 8897275 SGTC_2129 girgensonine 121.053 µM -1.05670306001481 0.125361760210587 no 2944 0.145323564009061 4162 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2247 cerulenin 830 nM -1.0577348559064 0.125130972112289 no 2945 0.145088169785314 4208 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_198 3454-2873 16.191 µM -1.05874897613993 0.124904426932201 no 2946 0.144857058292687 4133 710957 SGTC_2860 9025725 38.96 µM -1.05926632559759 0.124788966242047 no 2947 0.144739253206636 4180 40546248 SGTC_1047 2043-3044 82 µM -1.0599782902971 0.124630193810252 no 2948 0.144577238018869 4138 669592 SGTC_3198 9112019 49.47 µM -1.06191525263096 0.124198954329672 no 2949 0.144137080051997 4203 45595555 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -1.06238194574111 0.124095207409941 no 2950 0.144031163288615 4176 521171 SGTC_2859 9028643 45.46 µM -1.06268366035994 0.124028167857195 no 2951 0.143962716605854 4019 17151580 SGTC_297 0986-0032 24 µM -1.06352825132339 0.123840638542679 no 2952 0.143771230207882 4093 2847425 SGTC_516 3992-2719 87.3 µM -1.06420459388043 0.1236906095503 no 2953 0.143618013198933 4075 5350887 YDR037W KRS1 SGTC_752 1896-0090 130 µM -1.06442028663805 0.123642790501151 no 2954 0.143569173867586 4153 772567 SGTC_1612 st002233 45.4 µM -1.06537785275622 0.123430654560411 no 2955 0.143352487449777 4154 1035021 SGTC_2700 st077718 96.8 µM -1.0660527521343 0.123281292906661 no 2956 0.143199898069171 4149 904970 SGTC_1366 1683-0113 21.9 µM -1.06667950885386 0.123142699138778 no 2957 0.143058291642665 4169 708623 SGTC_2513 baicalein 25.65 µM -1.07159780171613 0.122058914693691 no 2958 0.141950360578481 4169 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_458 nppb 133 µM -1.07188798246192 0.121995181005956 no 2959 0.141885174296735 4201 4549 A chloride channel blocker. SGTC_1573 oleylamine 1.06 µM -1.07289087016027 0.121775092309878 no 2960 0.141660041429673 4149 5356789 An amine of the fatty acid oleic acid. SGTC_1429 4049-0205 9.46 µM -1.07409155765713 0.121511962585401 no 2961 0.141390823992815 4183 22774478 SGTC_177 1327-0068 8.361 µM -1.07499087609572 0.12131513961415 no 2962 0.141189406618431 4171 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_2758 dehydroepiandrosterone 69.35 µM -1.07643153423949 0.121000307568374 no 2963 0.140867152792481 4182 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_247 mechlorethamine 29.705 µM -1.08287665669243 0.119598872399629 no 2964 0.139431587208883 4075 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_2840 9008771 71.43 µM -1.08352271880065 0.119459025827088 no 2965 0.139288236185702 4113 2992978 SGTC_2643 anethole 100 µM -1.08737152891825 0.118628303375326 no 2966 0.13843632424408 4170 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_2212 7123476 200 µM -1.08788101358728 0.118518643510034 no 2967 0.138323819456411 4152 1085715 SGTC_914 3820-6779 408 µM -1.09174871237877 0.117688508164475 no 2968 0.137471783824338 4139 2893481 SGTC_679 0422-0091 41.4 µM -1.09374563428113 0.117261517651708 no 2969 0.137033276931066 4196 627384 YHR062C RPP1 SGTC_967 1306-0166 352 µM -1.09877280045678 0.116191448792891 no 2970 0.13593358950178 4214 4437607 SGTC_1965 Pectolinarigenin 58.4 µM -1.10183741894918 0.115542532294108 no 2971 0.13526617970159 4164 5320438 An anti-inflammatory. SGTC_909 3448-9333 149 µM -1.10305137982381 0.11528619593411 no 2972 0.1350024266128 4121 3344074 SGTC_379 3970-0972 5.9 µM -1.1059704103326 0.114671477463394 no 2973 0.134369663445528 4190 2898042 YBL034C STU1 SGTC_466 geldanamycin 89.2 µM -1.10605462054848 0.114653778319505 no 2974 0.134351439327789 4136 5288382 HSP90 inhibitor. SGTC_2171 5739187 198.077 µM -1.10663289353971 0.114532290504999 no 2975 0.134226339845903 4125 2262761 SGTC_2912 7964298 10.93 µM -1.10683215465291 0.114490449507958 no 2976 0.134183251648454 4200 2975850 SGTC_1784 st039334 36.3 µM -1.10777355640068 0.114292920399531 no 2977 0.133979811540094 4260 3496984 SGTC_2241 6772625 37.8075 µM -1.1103915501065 0.11374487744077 no 2978 0.133415168908936 4045 2285411 SGTC_3283 9109332 35.8195 µM -1.11267212808558 0.11326899678402 no 2979 0.132924635105658 4054 17027281 SGTC_246 cycloheximide 667 µM -1.1133090810576 0.113136340014561 no 2980 0.132787853812016 4088 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_363 0455-0021 3.06 µM -1.11398405650475 0.112995885410584 no 2981 0.132643013267128 4162 4597466 SGTC_2640 pentamidine 10.38 µM -1.11497650735744 0.112789593926459 no 2982 0.132430244533132 4188 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_3095 9117207 49.47 µM -1.11529750579074 0.112722928568349 no 2983 0.132361476951371 4182 17015229 SGTC_20 0481-0013 4.944 µM -1.11786384681585 0.112190959171225 no 2984 0.131812573936038 4239 182045 SGTC_583 1488-1091 88.9 µM -1.12116195764824 0.111509941366007 no 2985 0.131109464801471 4325 4303273 SGTC_1437 4092-1038 11.6 µM -1.12446575817635 0.110830719708889 no 2986 0.130407744519721 4248 3977136 SGTC_820 1582-0060 59.9 µM -1.12709662954079 0.110291968095658 no 2987 0.129850814116236 4232 3848840 SGTC_231 b-estradiol 524 µM -1.12717848054108 0.110275236770179 no 2988 0.129833513494184 4189 450 A steroid. SGTC_2248 tofa 1.1 µM -1.13200696820555 0.109291454809023 no 2989 0.128815752430471 4195 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1038 k292-0204 154 µM -1.13633546331709 0.108414917507872 no 2990 0.127908097087523 4179 4454212 SGTC_3121 9125696 49.47 µM -1.13645836408241 0.108390103683047 no 2991 0.127882390693954 4342 1235365 SGTC_2358 9037157 4 µM -1.1370301671015 0.108274709643995 no 2992 0.127762837397431 4229 2388925 SGTC_69 0096-0274 206.684 µM -1.13777040107086 0.108125456358336 no 2993 0.127608183750389 4359 6741392 SGTC_2969 9091408 28.7 µM -1.13862585081744 0.107953156682731 no 2994 0.12742962077561 4189 4286311 SGTC_236 1509-0011 5.31 µM -1.13912230969325 0.107853253558018 no 2995 0.127326071764658 4281 3107280 SGTC_2692 st077426 47.7 µM -1.13999190084815 0.107678424993442 no 2996 0.127144837687009 4249 25238571 SGTC_1733 st037357 54.9 µM -1.14032606709894 0.107611296255088 no 2997 0.127075240869573 4121 1272339 YGL099W LSG1 SGTC_541 4513-1321 94 µM -1.14111187272429 0.107453559117162 no 2998 0.126911685586453 4199 747515 SGTC_2141 5621638 7.665 µM -1.14193270508433 0.107288968981453 no 2999 0.126740996480843 4250 2856238 SGTC_2259 7964009 200 µM -1.14230877606537 0.107213621423955 no 3000 0.126662847307383 4258 313134 SGTC_779 1360-0071 233 µM -1.14316871878057 0.107041471322037 no 3001 0.126484273619986 4280 7566 SGTC_1204 4049-0315 18.3 µM -1.145124646402 0.106650660972703 no 3002 0.126078763614793 4291 588402 SGTC_1724 st037281 8.293 µM -1.14926718691066 0.105826350123471 no 3003 0.125222912024539 4205 574124 YDL195W SEC31 SGTC_694 1315-0438 43.2 µM -1.15002752103904 0.10567555521549 no 3004 0.125066268146745 4243 6793154 SGTC_89 0302-0250 142.109 µM -1.15247548959217 0.105191111960883 no 3005 0.12456286802155 4343 4203518 YLR208W SEC13 SGTC_795 0685-0265 78 µM -1.1546525785341 0.104761626605047 no 3006 0.124116363084519 4255 302754 SGTC_2311 7694451 200 µM -1.15948041777494 0.10381374777061 no 3007 0.123130207003103 4224 2163142 SGTC_670 4204-0025 119 µM -1.16204658549721 0.103312456028171 no 3008 0.122608271243142 4261 719039 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -1.16371270610765 0.102987927599075 no 3009 0.122270229229807 4236 803109 SGTC_672 1441-0018 53.7 µM -1.16852271035325 0.102055187001358 no 3010 0.12129799203263 4259 251141 SGTC_2864 9034755 47.6 µM -1.1694039616027 0.101884965921206 no 3011 0.121120457238998 4185 4930451 SGTC_2728 chlorpromazine 9.18 µM -1.17252677180903 0.101283432565008 no 3012 0.12049281504133 4347 2726 A thorazine and dopamine antagonist. SGTC_3227 9130768 49.47 µM -1.17302941755395 0.101186852369686 no 3013 0.120392004504865 4320 17720899 SGTC_1352 1496-0991 99 µM -1.17366763315266 0.101064320012774 no 3014 0.120264089726586 4244 3000039 SGTC_24 0417-1663 219 µM -1.17588041833335 0.100640320302343 no 3015 0.119821332409773 4286 4329390 SGTC_2319 6033012 152.6 µM -1.18960437577792 0.0980395748570825 no 3016 0.1171009625951 4219 847246 SGTC_2473 5854593 8.94 µM -1.18966569095985 0.098028066939855 no 3017 0.117088907671321 4172 2872951 SGTC_2484 5809818 12.04 µM -1.19138062789902 0.0977066005171936 no 3018 0.116752097187329 4244 2870548 SGTC_1912 st060209 90.8 µM -1.19204776252438 0.0975817545920342 no 3019 0.116621258917931 4272 688787 SGTC_767 0929-0023 86 µM -1.19366281100052 0.0972800028865769 no 3020 0.116304946655924 4292 1204563 SGTC_2400 5203494 178.7 µM -1.19511836642429 0.0970086375289911 no 3021 0.116020393548192 4191 6777674 SGTC_1709 st033179 39.1045 µM -1.19616132590607 0.0968145361866006 no 3022 0.115816804850284 4276 573381 SGTC_2047 4141938 200 µM -1.19783321684722 0.0965039819714526 no 3023 0.115490976454885 4291 3807862 SGTC_1109 tnp00067 928.257 nM -1.19884803872704 0.0963158358249163 no 3024 0.115293519671198 4290 676295 SGTC_1867 st057372 64 µM -1.20426027329386 0.0953169685860505 no 3025 0.114244498129342 4249 688837 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -1.20442700708382 0.0952863182055272 no 3026 0.114212289380014 4270 688667 SGTC_163 TUB2.036 7.546 µM -1.20547947240498 0.0950930128064159 no 3027 0.114009128952821 4265 15992207 YJR013W GPI14 SGTC_1933 st074711 15.9 µM -1.20820033246741 0.0945946135747661 no 3028 0.113485106966917 4271 17250958 SGTC_1337 1486-1011 40.3 µM -1.20938078293849 0.0943789820396348 no 3029 0.113258294035483 4262 X1337 SGTC_1497 4476-2978 41.3 µM -1.21054279631064 0.0941670726308521 no 3030 0.113035339656508 4334 1528379 SGTC_3211 9128781 49.47 µM -1.21128818433164 0.0940313256035277 no 3031 0.112892487784743 4274 17194361 SGTC_1440 4100-1550 40 µM -1.21247583139596 0.0938153345664882 no 3032 0.112665144335637 4288 742806 SGTC_2814 7977482 42.97 µM -1.21287139939545 0.0937434760887246 no 3033 0.11258949599339 4310 6456762 SGTC_1313 1220-0047 237 µM -1.21328842397441 0.0936677638388093 no 3034 0.112509783590247 4273 3528706 SGTC_1806 st050005 60.3 µM -1.21562188209476 0.0932449494443865 no 3035 0.112064497251425 4346 5194765 SGTC_1774 st048371 48.465 µM -1.21973841136967 0.0925024899838524 no 3036 0.111282027695031 4284 4242727 SGTC_1163 k060-0048 49.9 µM -1.22057320505888 0.0923524610302743 no 3037 0.111123828336844 4284 6809982 SGTC_1934 st074720 32.6 µM -1.2218209062059 0.0921285602491253 no 3038 0.110887680407231 4245 17250992 SGTC_440 fluspirilene 35.1 µM -1.22373519734696 0.0917858211195602 no 3039 0.110526068653704 4365 3396 An atypical antipsychotic. SGTC_2893 9048488 25.97 µM -1.22583484767317 0.0914109820024353 no 3040 0.110130415290886 4351 6467338 SGTC_2531 methyl deoxycholate 70.07 µM -1.22604009552324 0.0913744011939233 no 3041 0.110091793432365 4259 16667744 Haematoxylin. SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -1.22683132875515 0.0912334832332681 no 3042 0.109942996577833 4236 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_1005 4092-0690 4.4 µM -1.2290271694108 0.0908432501223105 no 3043 0.109530809760273 4329 1529343 SGTC_903 1134-0042 114 µM -1.22952617880586 0.0907547417855082 no 3044 0.109437294388695 4314 701009 SGTC_2595 hexamethylquercetagetin 100 µM -1.23002963741838 0.0906655091678523 no 3045 0.109343003352412 4316 386331 SGTC_2354 9060492 162 µM -1.23051378492246 0.0905797606721317 no 3046 0.109252384085371 4336 6471895 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -1.23108075397698 0.0904794200049251 no 3047 0.109146331480952 4271 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_1340 1486-1359 257 µM -1.23344219666896 0.0900623857767991 no 3048 0.108705415015444 4240 4309068 SGTC_1703 st026983 48.3 µM -1.2336974725257 0.0900173893660243 no 3049 0.108657828047009 4341 1104023 SGTC_118 0083-0097 135.343 µM -1.23875154145784 0.0891299658339385 no 3050 0.10771876235138 4293 5207356 SGTC_1479 0549-0158 134 µM -1.24277447265244 0.0884282621095062 no 3051 0.106975475918103 4389 5440202 SGTC_2904 7225135 42.03 µM -1.24937308584519 0.0872862184124252 no 3052 0.105764323833685 4400 4446116 SGTC_924 2046-0044 21.3 µM -1.24976032727667 0.0872195409407097 no 3053 0.105693556228246 4306 3623589 SGTC_3169 9102970 49.47 µM -1.25071340164064 0.0870555970770504 no 3054 0.105519529602064 4395 17027839 SGTC_3009 9080819 71.4286 µM -1.25162651199045 0.0868987436462007 no 3055 0.105352994669204 4349 17027216 SGTC_446 go6976 132 µM -1.25188889828033 0.086853710196452 no 3056 0.10530517530822 4356 3501 A protein kinase C inhibitor. SGTC_2685 mycophenolic acid 18.85 µM -1.25286966307701 0.08668553558697 no 3057 0.105126571993038 4322 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_3161 9100388 49.47 µM -1.25356176101152 0.0865670060748739 no 3058 0.1050006686949 4404 25236368 SGTC_1979 st071809 45.3 µM -1.25599767962049 0.0861507913137717 no 3059 0.104558405684135 4375 4976333 SGTC_2105 5350118 200 µM -1.25722259977722 0.0859420610599876 no 3060 0.104336520973819 4302 2133313 SGTC_2727 riluzole 51.77 µM -1.26069451222643 0.0853524929517071 no 3061 0.103709465948189 4372 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_1015 4130-4525 82 µM -1.26176428392322 0.0851714461721805 no 3062 0.103516808788447 4342 1363237 SGTC_1958 st076513 41.9 µM -1.26341765071021 0.0848921988030841 no 3063 0.103219562061616 4283 732122 YGL099W LSG1 SGTC_1915 st067105 30.6 µM -1.26348639170231 0.0848806035903527 no 3064 0.103207217054912 4273 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_2053 5265679 138 µM -1.26363796315461 0.0848550407525683 no 3065 0.103180000540805 4241 764595 SGTC_1230 0170-0365 3.77 µM -1.26369597528154 0.0848452584152929 no 3066 0.103169585130849 4375 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_1408 3909-7976 48.8 µM -1.26466139401858 0.0846825880708173 no 3067 0.102996367367905 4393 24152374 SGTC_1121 fusaric acid 630.51 nM -1.26935565722508 0.0838949503223841 no 3068 0.102157121956476 4308 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_518 1021-0119 62.6 µM -1.27173966125535 0.0834970572905059 no 3069 0.101732816906602 4315 1097762 SGTC_1772 st048439 82.2 µM -1.27267450278008 0.0833414188415312 no 3070 0.101566784484656 4397 2927068 YDL195W SEC31 SGTC_3305 9127027 53.8275 µM -1.27512403170927 0.0829346399244659 no 3071 0.101132672312362 4290 41905295 SGTC_893 0958-0369 48.9 µM -1.27959144740693 0.0821966110190398 no 3072 0.100344429664383 4259 6819948 SGTC_1668 st014914 51.6 µM -1.2821297539149 0.0817794858078578 no 3073 0.0998985664957714 4367 2839556 SGTC_1052 3253-3998 198 µM -1.28554183067156 0.0812212886705451 no 3074 0.099301504463341 4293 5450317 SGTC_1045 1348-1485 165 µM -1.28805799732128 0.0808115025858419 no 3075 0.098862887512836 4335 6810614 SGTC_282 k297-0036 65.7 µM -1.28948572551083 0.0805796761900202 no 3076 0.0986146378738053 4357 5061378 SGTC_1099 5-nonyloxytryptamine 2.85 µM -1.29219045697567 0.0801418750018458 no 3077 0.0981455978545505 4356 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_2345 9052315 157.45 µM -1.29221753602224 0.0801375009626768 no 3078 0.0981409102292493 4370 6469265 SGTC_2784 7567673 72.73 µM -1.29226895973692 0.0801291950612723 no 3079 0.0981320087755328 4291 3471247 SGTC_1744 st037937 38.9 µM -1.29396968185586 0.0798548628268783 no 3080 0.0978379466740421 4402 1016152 SGTC_1481 3346-2004 36 µM -1.29621616770794 0.0794935866086185 no 3081 0.0974505104709618 4435 2770522 SGTC_711 k292-0785 179 µM -1.29690890376301 0.0793824318068445 no 3082 0.0973312662902387 4285 4146315 SGTC_1228 0124-0032 52.5 µM -1.29866322938214 0.0791014630789314 no 3083 0.0970297641795726 4408 X1228 SGTC_2844 9010103 25.97 µM -1.30043508948707 0.0788184511396137 no 3084 0.09672594499754 4356 2480525 SGTC_359 0081-0058 15.9 µM -1.30108504300669 0.0787148292760813 no 3085 0.0966146734090499 4430 3494159 SGTC_2945 9067681 61.76 µM -1.30186078980736 0.078591287409513 no 3086 0.0964819892198537 4425 16456930 SGTC_277 nystatin 15.5 µM -1.30272423436378 0.0784539520883683 no 3087 0.0963344626517269 4382 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_272 doxorubicin 8.13 µM -1.30295639250731 0.0784170571898622 no 3088 0.0962948248274933 4393 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2330 7979373 200 µM -1.30399533275959 0.0782521084910363 no 3089 0.0961175868526093 4299 1863007 SGTC_972 1319-0219 195 µM -1.30524998345666 0.0780532631630185 no 3090 0.0959038696075443 4354 23903702 SGTC_997 3996-0078 137 µM -1.30640007735162 0.0778713256534554 no 3091 0.0957082697818515 4409 735687 SGTC_2293 7624732 200 µM -1.30932681868549 0.0774097856178373 no 3092 0.0952118344478014 4258 894453 SGTC_2140 5586273 200 µM -1.30995926140179 0.0773103244732411 no 3093 0.0951048087810445 4332 854421 SGTC_1243 0416-0003 5.65 µM -1.31242849275054 0.0769229298915537 no 3094 0.094687799222283 4374 2141977 SGTC_1945 st075991 56.6 µM -1.3131381864746 0.0768118603995447 no 3095 0.0945681941876769 4348 1084980 SGTC_2072 5231554 129 µM -1.31820566357982 0.0760223237601575 no 3096 0.0937174050618453 4431 789545 SGTC_789 1309-1135 70.6 µM -1.32212785831935 0.0754154810827812 no 3097 0.0930627892850352 4344 3092424 SGTC_3208 9114115 49.47 µM -1.32493001519146 0.0749841968844806 no 3098 0.092597182252467 4379 650895 SGTC_2110 5483698 200 µM -1.32529739439074 0.0749277927638424 no 3099 0.0925362664355239 4360 2848765 YHR062C RPP1 SGTC_1478 0453-0656 35.7 µM -1.32633372433181 0.0747688583342517 no 3100 0.092364590449157 4390 5258496 SGTC_1613 st002381 52.1 µM -1.33075402039039 0.0740938368029158 no 3101 0.0916349808221106 4381 551167 SGTC_1707 st032323 6.317 µM -1.33244950333563 0.0738361591762366 no 3102 0.0913562621760408 4228 3132057 YMR211W DML1 SGTC_1362 1611-0397 101 µM -1.33380345793935 0.0736308789307183 no 3103 0.0911341387179445 4359 27816 SGTC_1518 st038567 90.8 µM -1.33399470609232 0.073601917986441 no 3104 0.0911027957509862 4344 77966 SGTC_1950 st077106 7.18 µM -1.33462133721855 0.0735070874764316 no 3105 0.0910001554571253 4302 13831864 SGTC_1615 st002656 86.5 µM -1.33697192036628 0.0731521970816305 no 3106 0.0906159013561844 4406 1584458 SGTC_470 aa-861 153 µM -1.33772720310349 0.0730384434498735 no 3107 0.0904926899381189 4351 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_191 3914-0123 66.505 µM -1.34263158397542 0.0723030824229129 no 3108 0.089695649032979 4426 3144412 SGTC_179 1273-0063 6.77 µM -1.34294084354612 0.0722569030114885 no 3109 0.0896455648614333 4360 3108139 SGTC_2095 5432005 200 µM -1.34718061266568 0.071626087009584 no 3110 0.0889610351940132 4401 783734 SGTC_741 4582-0002 126 µM -1.34734397923524 0.0716018652469374 no 3111 0.0889347370020688 4420 2912688 SGTC_668 1682-0499 62.6 µM -1.353042053364 0.0707609591493043 no 3112 0.0880210980131235 4399 682214 SGTC_442 cape 100 µM -1.36006634477658 0.0697348011316938 no 3113 0.0869044650322955 4410 5281787 SGTC_928 2764-0428 58.7 µM -1.36232403233859 0.0694074262690563 no 3114 0.0865478232585786 4440 662578 SGTC_1983 st071813 46.9 µM -1.36239268183951 0.0693974903578148 no 3115 0.0865369960185595 4466 11838595 SGTC_616 4092-0450 108 µM -1.36298614588168 0.069311641647327 no 3116 0.086443438456282 4411 787165 SGTC_908 3448-7491 47.7 µM -1.36845459559138 0.068524437831487 no 3117 0.0855849124971398 4423 1203031 SGTC_1458 k015-0034 6.33 µM -1.36934918183982 0.0683963177918273 no 3118 0.0854450756137612 4445 3598957 SGTC_3326 9140064 16.379 µM -1.37224499068955 0.0679828557458622 no 3119 0.0849935919479963 4365 1868434 SGTC_3115 9123671 49.47 µM -1.37795986280302 0.0671725548148851 no 3120 0.0841078403607091 4565 3286988 SGTC_1256 0570-0116 285 µM -1.38366123196641 0.0663716301401333 no 3121 0.0832311047823225 4417 410638 SGTC_2122 5258151 111.688 µM -1.38898994618933 0.0656297599457061 no 3122 0.0824179036353958 4440 2173356 SGTC_122 0236-0016 402.397 µM -1.39040080491489 0.0654344189226117 no 3123 0.0822036010967078 4421 6808838 SGTC_2390 9097792 176.6 µM -1.39179271305527 0.0652421439075672 no 3124 0.0819925886135812 4464 4497149 SGTC_2926 9010726 65.15 µM -1.39380516396708 0.0649649239479314 no 3125 0.0816882241729726 4420 2994293 SGTC_3120 9124077 49.47 µM -1.39501732137916 0.0647983881120953 no 3126 0.0815053081413547 4546 18774327 YGL155W CDC43 SGTC_2452 5863136 48.41 µM -1.40214249232445 0.0638261678744864 no 3127 0.0804363501550921 4374 2184096 SGTC_3339 9145883 14.936 µM -1.40904776249431 0.0628948158015779 no 3128 0.079410522775088 4356 2030670 SGTC_1096 rimcazole 32.2 µM -1.41015654027743 0.0627462603657936 no 3129 0.0792467326315062 4379 18528119 A dopamine reuptake inhibitor. SGTC_393 acivicin 6.25 µM -1.41387138037252 0.0622505335957305 no 3130 0.0786998352188983 4301 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_3286 9117135 37.221 µM -1.41486499271003 0.0621184601732105 no 3131 0.0785540419061671 4401 3438150 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -1.41897639789209 0.0615742845197392 no 3132 0.0779529485900111 4504 279621 SGTC_1415 3966-0071 78.1 µM -1.41980604288318 0.061464927464266 no 3133 0.0778320776136815 4348 2893185 SGTC_3023 9089636 49.47 µM -1.42295715933729 0.0610509547112779 no 3134 0.0773742873407622 4531 17249241 SGTC_2144 5628481 200 µM -1.42372827562641 0.060949983230429 no 3135 0.0772625726253757 4436 2818399 SGTC_2903 5923464 63.88 µM -1.4237650681477 0.0609451688106227 no 3136 0.0772572454093902 4469 2876576 SGTC_2378 9074213 121.43 µM -1.42594341056975 0.0606606552207686 no 3137 0.0769423387175756 4418 657714 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -1.43014715645942 0.0601145414005362 no 3138 0.0763373941370214 4450 688669 SGTC_193 1273-0060 1.558 µM -1.43388707644756 0.0596319263532663 no 3139 0.0758022452161963 4293 2847393 YHR072W ERG7 SGTC_3356 9151811 4.48 µM -1.43552436048612 0.059421602203822 no 3140 0.0755688658268815 4470 1859254 YPR165W RHO1 SGTC_357 1325-0123 420 µM -1.43734094700027 0.0591889260278797 no 3141 0.0753105696998301 4469 1098503 SGTC_444 curcumin 90.4 µM -1.44792032909456 0.0578480413808134 no 3142 0.0738196667374291 4385 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_2416 tofa 880 nM -1.45232235539736 0.0572971908005107 no 3143 0.0732059971568664 4410 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_2776 terbinafine 19.92 µM -1.45234869293669 0.0572939075002151 no 3144 0.0732023373239251 4480 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1025 k007-0731 70 µM -1.45329702052486 0.0571757853366772 no 3145 0.0730706521034114 4444 6256118 SGTC_731 3966-0296 387 µM -1.45838532553973 0.0565452643916178 no 3146 0.0723671815875513 4467 660956 SGTC_1635 st007035 42.4 µM -1.46539798632888 0.0556852795735929 no 3147 0.0714061832601567 4429 3716403 SGTC_2302 7771753 200 µM -1.46761793464155 0.0554152018244932 no 3148 0.0711040167885467 4454 2203047 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -1.47050447436161 0.0550655748802785 no 3149 0.0707125873785633 4425 6708514 SGTC_279 1273-0055 2.93 µM -1.47531220024834 0.0544871190152574 no 3150 0.0700643139463013 4520 2847562 SGTC_2582 agaric acid 100 µM -1.47675683342273 0.0543142458912849 no 3151 0.0698704157361144 4077 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_785 1270-0111 65.3 µM -1.48210279775166 0.0536782883901515 no 3152 0.0691564722437268 4397 6741994 SGTC_1504 k297-0033 30 µM -1.48329273037283 0.0535375393246225 no 3153 0.068998326478674 4384 4388117 SGTC_1966 st070145 16.1 µM -1.48442429855731 0.0534039651798645 no 3154 0.0688481962349324 4456 3748532 SGTC_3206 9114350 49.47 µM -1.49397827335115 0.052286683453948 no 3155 0.0675906490567678 4350 17087243 SGTC_3050 9093513 49.47 µM -1.49889027396708 0.051719521983986 no 3156 0.0669510499782549 4441 25236664 SGTC_613 3914-0030 117 µM -1.50121163736172 0.0514531941177423 no 3157 0.0666504154681359 4218 1145395 SGTC_2614 arthonioic acid 13.39 µM -1.50744950552215 0.0507429305361593 no 3158 0.0658477387482612 4373 6710684 SGTC_2083 5306046 65.942 µM -1.51065547710505 0.0503809379621477 no 3159 0.0654381257642681 4484 539837 SGTC_2368 9071271 200 µM -1.51068935050822 0.0503771242644165 no 3160 0.0654338084822794 4476 27209959 SGTC_3167 9103034 49.47 µM -1.51659029324605 0.0497162591291475 no 3161 0.064685078819089 4580 5127859 SGTC_2936 9038235 15.59 µM -1.51853473429292 0.0495000164680497 no 3162 0.0644398250379745 4429 4749415 SGTC_1124 fisetin 1.16336 µM -1.51947295508536 0.0493959451148514 no 3163 0.0643217452597866 4519 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_1150 3909-7983 10.9 µM -1.52221606342743 0.0490926697973195 no 3164 0.0639774757340673 4509 23965914 SGTC_1130 3454-2858 15.9 µM -1.52258243787043 0.0490522766351076 no 3165 0.06393160315128 4467 715628 YIL048W NEO1 SGTC_2652 actinonin 100 µM -1.52566371759009 0.0487136120052072 no 3166 0.0635468173977009 4553 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_1327 1436-0082 2.18 µM -1.52762770843378 0.0484987260809663 no 3167 0.0633024990836278 4530 15992205 SGTC_263 alizarin 107.927 µM -1.52922188173739 0.0483248608663851 no 3168 0.0631047238885914 4548 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_2485 5633444 17.78 µM -1.5328672921226 0.0479291551694292 no 3169 0.0626542781268583 4484 5724239 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -1.53688648651796 0.0474958863851017 no 3170 0.0621605546440495 4523 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_2753 fluvastatin 17.09 µM -1.53927981284134 0.0472393801886247 no 3171 0.0618680000342257 4501 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_2008 4012253 172 µM -1.54262730474109 0.0468824745900178 no 3172 0.0614606145669937 4501 603940 SGTC_799 1310-0557 151 µM -1.54297322103192 0.0468457170280522 no 3173 0.0614186367228015 4537 5354492 SGTC_472 calcifediol 10 µM -1.5433595546812 0.0468046919885457 no 3174 0.0613717806043138 4549 5283731 A vitamin D metabolite. SGTC_167 3672-0051 66.205 µM -1.55945465876245 0.0451209997518002 no 3175 0.0594444040537979 4442 3237971 SGTC_2307 7538926 6.34 µM -1.5688379744942 0.044162130893227 no 3176 0.0583428487279105 4485 96582 SGTC_561 1550-0330 72.9 µM -1.57231026117351 0.0438114938543883 no 3177 0.0579393072349215 4494 6812934 SGTC_1964 st076914 61 µM -1.57268951318929 0.0437733328064137 no 3178 0.0578953646250517 4558 24208661 SGTC_2996 9066192 71.4286 µM -1.57890367530859 0.0431518632473109 no 3179 0.0571790764401284 4514 6472854 SGTC_2451 5856223 45.7 µM -1.58019350701714 0.0430237663966152 no 3180 0.0570312791424272 4530 2179896 SGTC_750 4073-0104 132 µM -1.58730418422875 0.0423230900296919 no 3181 0.0562218840191505 4226 22330957 SGTC_125 0133-0007 11.75 µM -1.58922583643305 0.0421353259382605 no 3182 0.0560047077231643 4621 26541 SGTC_119 0121-0043 24.815 µM -1.59562024553573 0.041515379013477 no 3183 0.0552868023109929 4559 1092378 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -1.60272895310441 0.0408348767127449 no 3184 0.054497254195517 4529 689007 SGTC_203 k066-0004 30.888 µM -1.60754007083703 0.040379474076472 no 3185 0.053967973292034 4596 6795412 SGTC_2137 5261020 140 µM -1.60957282183137 0.0401883048039517 no 3186 0.0537455727179167 4538 763655 SGTC_1788 fluconazole 20 µM -1.61159491235267 0.0399988681775224 no 3187 0.0535250592639677 4547 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_1091 telmisartan 47.6 µM -1.61497071461029 0.0396842284543967 no 3188 0.0531585184814784 4577 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_3026 9090633 49.47 µM -1.6152352029629 0.0396596622226318 no 3189 0.0531298849087046 4560 25236842 SGTC_362 0310-0100 9.03 µM -1.61575855501766 0.0396110886328399 no 3190 0.0530732627285138 4567 790235 SGTC_1377 2944-0135 198 µM -1.61698867478945 0.0394971086838798 no 3191 0.0529403627829567 4554 1894137 SGTC_3301 9125354 19.7965 µM -1.61770811692353 0.0394305706363019 no 3192 0.0528627579517739 4532 41905162 SGTC_2949 9072542 2.23 µM -1.61819337355485 0.0393857428966534 no 3193 0.0528104652370581 4522 16457352 SGTC_1862 st057513 3.81 µM -1.62637851462933 0.0386358330734014 no 3194 0.05193457927234 4548 5393163 SGTC_2966 9084041 48.03 µM -1.62877768846063 0.0384182427079946 no 3195 0.0516800447831928 4505 17741380 SGTC_2350 9023895 38.85 µM -1.63044081974346 0.0382679939247111 no 3196 0.0515041816717481 4527 2997209 SGTC_138 0850-0259 40.9225 µM -1.63539868294988 0.0378229370905755 no 3197 0.0509827491684372 4504 6813004 SGTC_40 0327-0103 19.753 µM -1.63607797452867 0.0377622888875609 no 3198 0.0509116346141022 4404 409036 SGTC_123 0083-0120 66.675 µM -1.6390302767571 0.0374996242617918 no 3199 0.0506034771554673 4546 16001701 SGTC_1400 3771-8998 51.5 µM -1.64175524193048 0.0372585115951201 no 3200 0.0503203690807806 4527 670767 SGTC_1910 st062352 60.4 µM -1.64377280982526 0.0370808087440441 no 3201 0.0501115698890352 4488 2245730 SGTC_417 st075190 100 µM -1.64419853127493 0.0370434007978035 no 3202 0.0500676001215322 4557 222757 SGTC_2332 7982454 138.89 µM -1.64656695204443 0.0368358515281359 no 3203 0.049823543964008 4465 2981748 SGTC_1990 st072050 59.8 µM -1.65346018201891 0.0362371903178601 no 3204 0.049118621696912 4565 17233948 SGTC_2087 5276107 200 µM -1.65471703806607 0.036128898544053 no 3205 0.0489909546476674 4565 144405 SGTC_1016 4226-1401 38 µM -1.65505646809634 0.036099698457489 no 3206 0.0489565220328034 4583 2901613 SGTC_2323 6148992 148.28 µM -1.65528440578537 0.0360801005514592 no 3207 0.0489334103282281 4527 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_1588 farnesol 29.9 µM -1.65878968311814 0.0357798152718301 no 3208 0.0485790899955804 4586 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_1684 st024538 14.6195 µM -1.66071595647727 0.0356156717938016 no 3209 0.0483852535886676 4561 6732859 SGTC_966 1300-0360 30.2 µM -1.66416896667704 0.035322975716098 no 3210 0.0480393339377673 4557 70588 SGTC_2730 imipramine 71.33 µM -1.66510371149946 0.0352440818332903 no 3211 0.0479460331981239 4533 3696 A tricyclic antidepressant. SGTC_2127 5253358 187.912 µM -1.66599987177541 0.0351685803218674 no 3212 0.0478567199870558 4507 20612 SGTC_782 0083-0095 30.5 µM -1.67067408869433 0.0347769257475543 no 3213 0.0473930347868397 4548 3591729 An indicator and reagent. SGTC_2192 5915882 198.485 µM -1.6756294937121 0.0343656285635055 no 3214 0.0469053940048355 4577 2876149 SGTC_151 3013-0144 2.285 µM -1.68682191722079 0.033451359840571 no 3215 0.0458187998878289 4338 906558 YHR107C CDC12 SGTC_1787 fluconazole 80 µM -1.69910202097112 0.03247137909676 no 3216 0.0446499813414732 4235 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_202 3594-0513 34.79 µM -1.70238791928741 0.0322132112506022 no 3217 0.0443413365896352 4666 708429 SGTC_250 brefeldin a 552.239 µM -1.70260523422627 0.032196197058514 no 3218 0.0443209849433707 4545 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -1.70294501983066 0.0321696091635867 no 3219 0.0442891789496849 4578 442882 SGTC_2445 5742597 35.57 µM -1.70829647843822 0.0317532480028838 no 3220 0.0437906722073268 4591 1774255 SGTC_2421 5690543 90.72 µM -1.70975437161549 0.0316405939516723 no 3221 0.0436556518815428 4582 3397993 SGTC_520 3584-0023 682 µM -1.71061794764062 0.0315740197720518 no 3222 0.0435758318006525 4572 1340790 SGTC_1105 epirubicin 18.1 µM -1.71341160518881 0.0313594457647098 no 3223 0.0433184213840607 4625 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1397 3532-0190 20.1 µM -1.7193653156306 0.0309061775152151 no 3224 0.0427739368297488 4595 5322280 SGTC_3252 9135871 49.47 µM -1.7287515333009 0.0302026077003484 no 3225 0.0419267869195015 4616 17682838 SGTC_1087 pterostilbene 9.05 µM -1.72938682055496 0.0301554716128597 no 3226 0.0418699436026248 4596 5281727 Similar to reservatol, lowers cholesterol. SGTC_2089 5281248 129.67 µM -1.73189826241016 0.0299697281031667 no 3227 0.0416458390939963 4587 2737878 SGTC_2113 5491891 107.031 µM -1.73476930198661 0.0297585524619651 no 3228 0.0413908377999339 4588 789979 SGTC_1293 1000-1278 195 µM -1.73485426446098 0.0297523220119642 no 3229 0.0413833108855097 4621 678847 SGTC_619 1652-1634 108 µM -1.7416781352719 0.0292554380605981 no 3230 0.0407823902596595 4596 5400454 SGTC_1947 st076332 61.6 µM -1.74418975697098 0.0290742968167 no 3231 0.0405630034225935 4475 24208416 SGTC_730 1436-0052 41.2 µM -1.76423626609242 0.0276616660146986 no 3232 0.0388461046349461 4632 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_1108 betulinic acid 729.144 nM -1.76445140780987 0.0276468214000499 no 3233 0.0388280047814286 4601 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_3288 9119690 36.221 µM -1.76479594949909 0.027623062117106 no 3234 0.0387990328288232 4595 17595618 YKL019W RAM2 SGTC_1956 st077085 54 µM -1.77651358110849 0.0268250998974345 no 3235 0.0378241527232426 4627 24208685 SGTC_3240 9133527 49.47 µM -1.78797365156064 0.0260633862682236 no 3236 0.0368901294457508 4610 17617455 SGTC_419 nsc-638432 893 µM -1.79259783848742 0.0257611961506264 no 3237 0.0365186261476428 4612 368090 SGTC_2797 7859098 81.82 µM -1.7980115364498 0.0254111432645379 no 3238 0.0360875898078829 4583 972681 SGTC_1755 st041960 45.185 µM -1.80023648828469 0.0252684362561145 no 3239 0.0359116522989034 4648 2257073 SGTC_2029 5175081 200 µM -1.80855416351714 0.0247408796526758 no 3240 0.0352601474761329 4581 1380876 SGTC_697 0508-1955 564 µM -1.8175916958793 0.0241781705846597 no 3241 0.0345632808949166 4640 6243113 SGTC_2807 7945238 51.95 µM -1.81810215439063 0.0241467109815989 no 3242 0.0345242603955096 4606 17148797 SGTC_244 nsc-207895 1.295 µM -1.81938843200175 0.0240675900361199 no 3243 0.034426095157747 4477 42640 SGTC_2064 5220758 200 µM -1.82479206885467 0.0237375794878826 no 3244 0.0340162065861409 4641 788518 SGTC_1761 st044296 37 µM -1.83988138408766 0.0228361317371019 no 3245 0.0328928268254478 4653 1826700 SGTC_2000 st075254 36.4 µM -1.84209166935011 0.0227065410940993 no 3246 0.0327308710800156 4551 17234175 SGTC_2068 5226020 147 µM -1.85162883408145 0.0221544554408079 no 3247 0.0320395698021983 4651 1810509 SGTC_1517 deoxycholic acid methyl ester 49.2 µM -1.86796479011933 0.0212351252938334 no 3248 0.0308834894391871 4632 229346 A bile salt which induces apoptosis. SGTC_2315 7733312 200 µM -1.87266096333286 0.0209768896438194 no 3249 0.0305576085708424 4562 726316 SGTC_1765 st044815 90.4 µM -1.89506389964316 0.0197812738586801 no 3250 0.0290419682956741 4662 645695 SGTC_2662 daunorubicin 22.37 µM -1.90839109306123 0.0190978407978413 no 3251 0.0281703435966976 4555 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_3222 9128301 49.47 µM -1.91740385491481 0.0186471235797753 no 3252 0.0275933224417098 4610 4911358 SGTC_2198 6589944 200 µM -1.91828201384973 0.0186036960191667 no 3253 0.0275376308939915 4677 5290268 SGTC_1483 3453-0561 55.9 µM -1.9199191242449 0.018522965916943 no 3254 0.0274340579350233 4695 4546991 SGTC_1310 1188-0297 994 nM -1.92079026927645 0.0184801292579395 no 3255 0.0273790768649433 4562 1588352 SGTC_3051 9093778 49.47 µM -1.9342784498751 0.0178275676312459 no 3256 0.0265394506870712 4736 17217378 SGTC_2325 6158266 200 µM -1.93584297718774 0.0177531632252923 no 3257 0.0264434677165935 4630 3623240 SGTC_2467 5474540 200 µM -1.93689540858605 0.0177032618138368 no 3258 0.02637906491393 4659 5413519 SGTC_478 N-arachidonylglycine 10 µM -1.94539017414068 0.0173048439624088 no 3259 0.0258640182238637 4705 5283389 SGTC_2387 9077560 195.08 µM -1.95253797733556 0.0169755587717503 no 3260 0.0254371833258001 4669 5303272 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -1.95359766927853 0.0169271997339197 no 3261 0.025374408246876 4709 688664 SGTC_1232 0279-0259 161 µM -1.95369876427457 0.0169225924249669 no 3262 0.0253684262680524 4665 1560000 SGTC_1336 1486-0901 104 µM -1.95412240630512 0.0169032969992397 no 3263 0.0253433714278307 4673 5006114 SGTC_120 rhodamine 6G 52.259 µM -1.97375806077919 0.0160293724116729 no 3264 0.0242046298621475 4665 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_1575 cyproterone acetate 48 µM -1.97755439619628 0.0158649529165023 no 3265 0.0239894991170341 4654 9880 An androgen receptor antagonist and liver toxin. SGTC_2283 7944793 200 µM -1.98136498444995 0.0157013725715958 no 3266 0.0237751787895828 4646 2970533 SGTC_1335 1486-0900 202 µM -2.01503062876577 0.014317994759843 no 3267 0.0219507199645685 4691 X1335 SGTC_796 1234-0020 70.7 µM -2.01608691036138 0.0142763450464728 no 3268 0.0218954442793275 4657 46495034 SGTC_1485 3909-9022 254 µM -2.03937691360147 0.013384168408772 no 3269 0.020706212350636 4746 714516 SGTC_354 2783-3500 4.88 µM -2.04175027415893 0.0132960143779306 no 3270 0.0205881545305077 4685 6740761 SGTC_2920 7982904 15.77 µM -2.04597128124556 0.0131404717885132 no 3271 0.0203795981508032 4663 6456808 SGTC_2313 7726885 200 µM -2.04628359582232 0.0131290258432134 no 3272 0.0203642383513518 4679 726423 SGTC_1484 3473-2379 286 µM -2.04632471080941 0.0131275196714668 no 3273 0.0203622170251582 4764 671917 SGTC_2263 7948595 193.29 µM -2.05748641902583 0.0127241147744655 no 3274 0.0198197299839931 4700 2971371 SGTC_477 mead ethanolamide 10 µM -2.06996111928403 0.0122859911222988 no 3275 0.0192279927983618 4728 16061185 SGTC_2235 salicylic acid 500 µM -2.07201506349231 0.0122151221484211 no 3276 0.019132018211595 4743 338 A COX inhibitor and kinase inhibitor. SGTC_3191 9110352 49.47 µM -2.07816856246539 0.0120049192785242 no 3277 0.0188469182662116 4671 17122424 SGTC_1049 3226-0134 66 µM -2.08127657864473 0.0118999471740056 no 3278 0.018704298838613 4703 5702385 SGTC_2951 9072950 58.06 µM -2.08391137504089 0.0118115824211402 no 3279 0.0185841147324751 4647 16488155 SGTC_1371 2421-0008 32.7 µM -2.08559741582589 0.0117553358775502 no 3280 0.0185075528184494 4700 2827552 SGTC_1102 cgs 12066b 26.1 µM -2.10616319980457 0.0110877487977222 no 3281 0.0175950892826048 4737 6438352 A 5-HT1B full agonist. SGTC_1247 0448-0043 5.84 µM -2.13067529477294 0.0103353395280118 no 3282 0.0165579508729898 4686 3089013 YGL099W LSG1 SGTC_2032 5185112 25.99 µM -2.13645289093871 0.0101646170244984 no 3283 0.0163212584452688 4629 5718189 SGTC_2475 5812728 15.03 µM -2.16780982410535 0.00928030509162777 no 3284 0.0150865795328227 4689 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_954 1189-0853 2.85 µM -2.16830367663426 0.00926693388867068 no 3285 0.0150677944438358 4674 2828194 SGTC_2773 thioridazine 9.09 µM -2.16939589913571 0.00923742150209621 no 3286 0.0150263200242711 4716 5452 An antipsychotic. SGTC_1610 st001799 48.1 µM -2.17233121023699 0.00915851517436394 no 3287 0.0149153447705751 4692 621897 SGTC_2630 antimycin a 100 µM -2.1744298395759 0.00910246266255216 no 3288 0.0148364345772918 4646 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_1473 k844-0725 134 µM -2.18380861965438 0.00885561874244326 no 3289 0.014488156973121 4747 54682906 SGTC_2962 9082311 13.18 µM -2.20405871347832 0.00834257071970347 no 3290 0.0137601076053492 4716 16459453 SGTC_614 0462-0418 107 µM -2.20698859124416 0.00827054409498505 no 3291 0.0136574282023907 4563 5188303 SGTC_1373 2887-0003 58.5 µM -2.21176008002762 0.00815441292483555 no 3292 0.013491623381243 4686 776948 SGTC_1127 asiatic acid 681.4 nM -2.22087152410891 0.00793662822390731 no 3293 0.0131798322147964 4699 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_1471 k673-0312 37 µM -2.22470773603875 0.00784647479585836 no 3294 0.0130504323036319 4748 24099884 SGTC_1227 3909-8010 46.6 µM -2.22983925245135 0.00772728999921927 no 3295 0.0128790582364273 4734 15982272 SGTC_374 0880-0231 82.3 µM -2.23129841164078 0.00769369176953918 no 3296 0.012830684413762 4629 6833587 SGTC_547 1120-0019 610 nM -2.23746548324204 0.00755310644543103 no 3297 0.0126279664168614 4716 3676939 SGTC_2382 9035899 200 µM -2.25597685087861 0.00714461473259661 no 3298 0.0120360404644921 4727 6462679 SGTC_1899 st063254 59.6 µM -2.26518602486705 0.00694875147300256 no 3299 0.0117506331849328 4729 3093813 SGTC_2146 5545642 200 µM -2.26899004272178 0.00686924010292914 no 3300 0.0116344656978846 4720 825326 SGTC_2111 5486399 200 µM -2.2925147564004 0.00639514118430863 no 3301 0.0109379785151465 4711 689674 SGTC_1522 st012842 45.6 µM -2.31769575440118 0.00591996754215881 no 3302 0.0102329309662217 4621 3491067 YOR116C RPO31 SGTC_630 4356-0227 183 µM -2.32013317661667 0.00587567800474493 no 3303 0.0101668370507694 4718 779312 SGTC_2112 5488546 200 µM -2.3281818768435 0.00573150832768214 no 3304 0.00995122404985607 4719 600757 SGTC_473 2-arachidonoylglycerol 10 µM -2.33256692387932 0.00565429128742752 no 3305 0.00983544331044932 4649 5282280 An endocannabinoid. SGTC_1992 st073643 23.3 µM -2.3364413398791 0.00558683609667518 no 3306 0.00973412575479291 4746 3161292 SGTC_1926 methyl fluorone black 53.6 µM -2.35079425643657 0.00534313215044993 no 3307 0.0093666944846056 4464 72721 Reacts with homocysteine. SGTC_2726 cimetidine 79.27 µM -2.3552274141366 0.00526979467079608 no 3308 0.0092556864486754 4770 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_314 1671-0008 2.74 µM -2.37193225793908 0.00500142643112419 no 3309 0.00884766735268146 4645 3913060 SGTC_2826 7992541 19.48 µM -2.39255548688717 0.00468694148011135 no 3310 0.00836574899474933 4733 2985066 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -2.39761255757994 0.0046125713575338 no 3311 0.00825115499356439 4739 6312947 SGTC_1609 st001574 46.4 µM -2.40061558160539 0.00456890844556474 no 3312 0.00818376044298103 4754 3960012 SGTC_523 1934-0222 13.7 µM -2.42097996385772 0.00428242686728858 no 3313 0.00773936520287803 4748 1361595 SGTC_1290 0986-0249 10.2 µM -2.42337130312923 0.0042498622530479 no 3314 0.00768860035829116 4698 53329 SGTC_2423 st077119 87.2 µM -2.43889585847626 0.0040437850361606 no 3315 0.00736610659473989 4682 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_2065 5221596 34.26 µM -2.44827646795464 0.00392364412555485 no 3316 0.00717707332292279 4733 788581 SGTC_514 4466-0038 2.65 nM -2.48824391910695 0.00344682217630319 no 3317 0.00641878261013154 4623 5722064 SGTC_1786 berberine 21.6 µM -2.49229360297987 0.00340153860439337 no 3318 0.0063460536343957 4692 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1251 0490-5699 265 µM -2.5011114848343 0.0033047814939762 no 3319 0.00619020993260154 4753 3883818 SGTC_1614 st002383 48.6 µM -2.50130160627812 0.00330272285742659 no 3320 0.00618688746610103 4781 1947235 SGTC_3192 9110362 49.47 µM -2.55132935780999 0.00279944355440897 no 3321 0.00536564302053362 4752 16649480 SGTC_2033 5192550 145 µM -2.58518338115096 0.00249928048450307 no 3322 0.00486636085214142 4760 182073 SGTC_1960 st011366 51.8 µM -2.58707785555346 0.00248337675958641 no 3323 0.00483968594679701 4782 3972846 SGTC_1986 st071812 45 µM -2.6386738611542 0.00208393854940722 no 3324 0.00416155048606469 4754 11838594 SGTC_1252 0493-0875 34.8 µM -2.64554646124954 0.00203538096161045 no 3325 0.00407795429399974 4764 3960963 SGTC_1886 st057356 49.9 µM -2.71155942414021 0.0016186637719934 no 3326 0.00334837681848671 4782 24207747 SGTC_2775 cyproheptadine 69.59 µM -2.7179014569957 0.00158303212724955 no 3327 0.0032848700751204 4774 2913 A selective serotonin reuptake inhibitor. SGTC_1006 4099-6547 255 µM -2.77545151627241 0.00129090866179686 no 3328 0.00275625589246481 4780 3146833 SGTC_2062 5245942 200 µM -2.77961020689775 0.00127184016567835 no 3329 0.00272120913799207 4783 1376160 SGTC_1237 0330-0133 46.1 µM -2.81054868893416 0.00113787114238999 no 3330 0.00247285526397851 4765 X1237 YHR072W ERG7 SGTC_2600 tangeritin 87.95 µM -2.81195505638986 0.00113210027890705 no 3331 0.00246206915741743 4762 68077 A bioactive flavone. SGTC_2405 ticlatone 3.52 µM -2.81742360401678 0.00110991467121849 no 3332 0.00242053149998746 4685 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_2923 7992654 58.14 µM -2.83285537041876 0.00104943992924433 no 3333 0.00230671271321322 4768 2985126 SGTC_673 1082-0474 110 µM -2.86178191492114 0.000944152146066468 yes 3334 0.00210633333649934 4773 3098046 SGTC_631 k072-0230 41.5 µM -2.86543223412898 0.000931578423219035 yes 3335 0.0020822019672505 4786 5773147 SGTC_160 3453-0671 289.699 µM -2.89523264925562 0.000834540576893724 yes 3336 0.0018943880748962 4757 5322268 SGTC_2779 methotrexate 400 µM -2.94788160177957 0.00068550596593777 yes 3337 0.00159979791188197 4777 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_411 enrofloxacin 100 µM -2.95116568683279 0.000677077022005055 yes 3338 0.00158288523533548 4800 71188 A bacterial gyrase inhibitor. SGTC_2714 st079313 56.9 µM -2.9602583252674 0.000654236082169142 yes 3339 0.00153690591271738 4793 2939799 SGTC_299 1273-0059 1.44 µM -2.97658649421684 0.00061499553887381 yes 3340 0.00145738424849759 4643 2848077 SGTC_1126 isoteolin 1.0172 µM -3.01473062737078 0.000531644223542777 yes 3341 0.00128603790116075 4779 133323 SGTC_2269 7935389 174.42 µM -3.02498627377333 0.000511088594686044 yes 3342 0.00124322205718829 4791 97605 SGTC_1474 0330-0125 5.35 µM -3.14324244440327 0.000321650592308862 yes 3343 0.000835436924725558 4805 X1474 SGTC_2266 7929956 200 µM -3.17163158170245 0.000287146686832246 yes 3344 0.000757925894398245 4784 2967153 SGTC_2268 7933382 153.85 µM -3.18707152452059 0.000269860166920456 yes 3345 0.000718606145568315 4786 935025 YOR257W CDC31 SGTC_690 glyoxal 20.3 µM -3.49358174646717 7.44739915948711e-05 yes 3346 0.00023829352367784 4745 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_2834 9001755 58.44 µM -3.52994790703917 6.34812524949838e-05 yes 3347 0.000207820748144203 4739 2989575 SGTC_1001 4048-4355 44.4 µM -3.56039777500816 5.54722667444564e-05 yes 3348 0.000185146722526505 4800 21824233 SGTC_324 1315-0088 19.6 µM -3.6451244201414 3.79081905182118e-05 yes 3349 0.000133631234416104 4807 6787421 SGTC_304 1310-0298 97 µM -4.29626776256882 1.55211305911721e-06 yes 3350 8.68488791179968e-06 4758 1550234 SGTC_2070 5230947 200 µM -4.30677881744892 1.46829550763326e-06 yes 3351 8.28245482499776e-06 4809 2835538 SGTC_2922 7999257 32.47 µM -4.48005317269572 5.77447143016931e-07 yes 3352 3.7312223200203e-06 4805 2988377 SGTC_58 0957-0393 9 µM -4.49371968945032 5.35691642945633e-07 yes 3353 3.49948724620972e-06 4666 6997992 SGTC_327 1273-0057 3.96 µM -5.08559429555126 1.69222687890834e-08 yes 3354 1.83238347528971e-07 4808 3108138 SGTC_310 1273-0058 1.06 µM -5.36955821990595 2.7978504525458e-09 yes 3355 3.94648768282927e-08 4725 2734232 SGTC_1107 amlodipine 47 µM -6.71916042832702 1.51735883642387e-13 yes 3356 9.1387295585817e-12 4782 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.