SGTCid condition conc unit RPL32|YBL092W.score RPL32|YBL092W.strain.pval RPL32|YBL092W.strain.significant RPL32|YBL092W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_1652 st011932 78 µM 16.1543165088347 5.89477737485038e-35 yes 1 5.29428421022344e-59 4 1551076 SGTC_1374 2889-5571 141 µM 13.6665444804294 1.36706814915372e-25 yes 2 8.04271247986179e-43 6 2853281 SGTC_22 0964-0034 14.468 µM 13.5796038499045 2.72463042896746e-25 yes 3 2.6455919984555e-42 1 138402 SGTC_445 e6 berbamine 66 µM 12.3875314714098 2.25524506817111e-21 yes 4 1.52648463789469e-35 4 6610268 A calcium/calmodulin antagonist. SGTC_1707 st032323 6.317 µM 11.798541122254 1.44254543705465e-19 yes 5 1.98568369342887e-32 2 3132057 YMR211W DML1 SGTC_829 1635-0120 117 µM 10.4092966355861 1.20010594303454e-15 yes 6 1.12438479029419e-25 6 285054 SGTC_2109 5483026 200 µM 10.3545754263577 1.67448157831778e-15 yes 7 1.9947632970224e-25 7 759335 SGTC_2912 7964298 10.93 µM 10.3541101062921 1.67921895531149e-15 yes 8 2.00448589526425e-25 13 2975850 SGTC_3347 9188721 44.724 µM 9.77654129096386 5.09238482052882e-14 yes 9 7.09898038030425e-23 4 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_1239 0337-0584 35.4 µM 9.55784325558563 1.76434517772246e-13 yes 10 6.01180769966336e-22 6 914301 YML130C ERO1 SGTC_157 1348-1695 65.819 µM 9.44583878343732 3.29923540286907e-13 yes 11 1.76284525614636e-21 6 5380510 SGTC_2361 9034121 116 µM 9.28469404717622 8.01854137399117e-13 yes 12 8.10862106293695e-21 5 6496917 SGTC_2293 7624732 200 µM 9.13362522173163 1.81915150981161e-12 yes 13 3.31215269242904e-20 1 894453 SGTC_514 4466-0038 2.65 nM 8.94191021124861 5.05009199299681e-12 yes 14 1.91250161493043e-19 4 5722064 SGTC_332 4112-0506 40.9 µM 8.88875991131335 6.6778619469937e-12 yes 15 3.08973457802063e-19 2 2790355 SGTC_2192 5915882 198.485 µM 8.56624592016087 3.51608641365607e-11 yes 16 5.34567145517701e-18 5 2876149 SGTC_1672 st016598 6.51 µM 8.00843729103501 5.41609473123668e-10 yes 17 5.80875868883628e-16 3 4665860 YNL267W PIK1 SGTC_586 0957-0265 8.15 µM 7.93329102406378 7.72440600038619e-10 yes 18 1.06706765655036e-15 16 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_2544 sphondin 68.51 µM 7.36083806770138 1.04028597541509e-08 yes 19 9.1379580086915e-14 14 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_1745 st081495 74 µM 7.28029123160955 1.47788865785484e-08 yes 20 1.66550146672784e-13 11 13842402 YBL026W LSM2 SGTC_1774 st048371 48.465 µM 7.13158980349805 2.79906740070881e-08 yes 21 4.96080932966907e-13 1 4242727 SGTC_839 0122-0028 230 µM 6.57816116931261 2.70489885947783e-07 yes 22 2.38150898973528e-11 7 759448 SGTC_1915 st067105 30.6 µM 6.53727369379424 3.17679447175926e-07 yes 23 3.13251694918852e-11 18 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_221 trifluoperazine 10.304 µM 6.48289998190201 3.92858346205503e-07 yes 24 4.4988074394893e-11 12 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_2111 5486399 200 µM 6.32751630728375 7.14349282736775e-07 yes 25 1.24569324885117e-10 14 689674 SGTC_227 fluconazole 33.516 µM 6.2994631067113 7.94641364158774e-07 yes 26 1.49339189460491e-10 26 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_3200 9114385 49.47 µM 6.23101038565737 1.02861893232244e-06 yes 27 2.31718189632285e-10 3 17018030 YLR208W SEC13 SGTC_764 1951-2361 146 µM 6.14097558565233 1.43864955316626e-06 yes 28 4.10080951415457e-10 5 5438930 SGTC_2686 alizarin 95.37 µM 5.94646183856353 2.92457591887147e-06 yes 29 1.37000188073068e-09 3 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_3311 9131146 2.8755 µM 5.73229264514975 6.23417588302898e-06 yes 30 4.95410634989931e-09 7 4900406 YPR165W RHO1 SGTC_928 2764-0428 58.7 µM 5.73193913250063 6.24183854876114e-06 yes 31 4.96444526743384e-09 8 662578 SGTC_1651 st011928 86.1 µM 5.71309925715735 6.66346474222434e-06 yes 32 5.54684640629543e-09 6 720198 SGTC_138 0850-0259 40.9225 µM 5.68427555900198 7.36150016404979e-06 yes 33 6.56841585872115e-09 36 6813004 SGTC_16 erodoxin 22.806 µM 5.66402422148199 7.89306551669542e-06 yes 34 7.39317605426696e-09 12 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_3322 9139058 2.11 µM 5.65344376843517 8.18514304412927e-06 yes 35 7.86322885414943e-09 3 4908926 YPR165W RHO1 SGTC_3304 9125678 46.087 µM 5.53174539217075 1.23768053460375e-05 yes 36 1.58529951055052e-08 23 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_2187 6125751 200 µM 5.5302181322337 1.24405534497965e-05 yes 37 1.59916413647476e-08 5 874498 SGTC_1493 4348-0038 111 µM 5.49043994599787 1.42152391069186e-05 yes 38 2.00466899498138e-08 22 800424 SGTC_525 k781-2675 26.7 µM 5.47231128575917 1.51015921078015e-05 yes 39 2.2210183997322e-08 29 3651118 YDL195W SEC31 SGTC_3247 9135149 49.47 µM 5.46010704949245 1.57276013477365e-05 yes 40 2.37923788595749e-08 13 8934436 YOR116C RPO31 SGTC_480 am 92016 50 µM 5.44420838566529 1.65801583341603e-05 yes 41 2.6018137290691e-08 1 2129 K+ channel blocker. SGTC_93 0109-0045 59.227 µM 5.40629733077176 1.87937431014336e-05 yes 42 3.2170477494189e-08 5 88733 SGTC_1213 1315-0166 115 µM 5.35465144671496 2.22639791474307e-05 yes 43 4.28607486565182e-08 9 768401 SGTC_1803 st050068 52.4 µM 5.31787612099927 2.50966134050225e-05 yes 44 5.24927522491037e-08 10 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_45 0kpi-0036 14.9 µM 5.24460016282856 3.17898875394932e-05 yes 45 7.83108014185728e-08 3 2795021 SGTC_2291 7917025 104.35 µM 5.12257127124183 4.68203157638066e-05 yes 46 1.50698557821316e-07 4 2964612 SGTC_1274 0865-0114 173 µM 5.10242732670967 4.98712143398464e-05 yes 47 1.67662264756908e-07 4 870624 SGTC_871 0574-0004 149 µM 5.05447146666058 5.79066763225099e-05 yes 48 2.15792136296365e-07 18 9551173 SGTC_1696 st025591 34.7925 µM 5.04846919942055 5.89943598497509e-05 yes 49 2.22682127695032e-07 3 2787147 SGTC_1050 3232-1156 69.3 µM 5.00965691209976 6.6506365256186e-05 yes 50 2.72635769033824e-07 14 700529 SGTC_2477 5967686 25.23 µM 4.99685964443885 6.91747604397992e-05 yes 51 2.91357239061607e-07 2 776118 SGTC_2229 7354935 190 µM 4.99434256958738 6.97113348726296e-05 yes 52 2.95182629711259e-07 15 318112 SGTC_490 phenamil 164 µM 4.98183507582978 7.24362443491602e-05 yes 53 3.14920528702713e-07 3 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_2997 9067075 71.4286 µM 4.97077220527474 7.49297195704924e-05 yes 54 3.33433816756622e-07 14 27209819 SGTC_824 1304-0008 100 µM 4.9661139769557 7.60036336171262e-05 yes 55 3.41539093110287e-07 4 768245 SGTC_492 tmb-8 126 µM 4.93668788169345 8.31296610772018e-05 yes 56 3.97302428567193e-07 2 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_796 1234-0020 70.7 µM 4.89778093669454 9.35195521774227e-05 yes 57 4.84625011926265e-07 3 46495034 SGTC_451 chloral hydrate 100 µM 4.8938950131614 9.46217688496091e-05 yes 58 4.94297953039405e-07 7 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_2485 5633444 17.78 µM 4.89130659320727 9.53627198299835e-05 yes 59 5.00843956807038e-07 6 5724239 SGTC_2292 7671323 168.05 µM 4.86536760167701 0.000103095157457334 yes 60 5.7122133947236e-07 6 937504 SGTC_2140 5586273 200 µM 4.77203722279464 0.000136065733889474 yes 61 9.11858941509923e-07 9 854421 SGTC_248 streptozotocin 5.23457 mM 4.76552625018501 0.000138700788024307 yes 62 9.41806854821778e-07 12 5300 DNA alkylating agent. SGTC_287 k060-0039 29.6 µM 4.75215020673753 0.000144264942639613 yes 63 1.00632380959074e-06 4 5861974 SGTC_673 1082-0474 110 µM 4.69068961576163 0.000172625555303509 yes 64 1.36142879340032e-06 42 3098046 SGTC_946 3434-1334 87.4 µM 4.65731444160107 0.000190132939891465 yes 65 1.60180474579481e-06 6 4047976 SGTC_964 1287-0107 19.4 µM 4.61237813905494 0.000216334753930635 yes 66 1.99043968240183e-06 14 51516812 YPR165W RHO1 SGTC_546 peri-Naphthalide 147 µM 4.5931352946847 0.000228554960314219 yes 67 2.18317888731912e-06 17 223824 A penicillin ester. SGTC_518 1021-0119 62.6 µM 4.58879841757747 0.000231396636960557 yes 68 2.22902332841617e-06 5 1097762 SGTC_214 4373-3496 70 µM 4.52729737643601 0.000275410286078231 yes 69 2.98714198877357e-06 11 3779166 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 4.52242484860795 0.000279211572803086 yes 70 3.05675977675431e-06 11 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_2467 5474540 200 µM 4.48164805405465 0.000312993494340728 yes 71 3.70344104349763e-06 3 5413519 SGTC_2679 rapamycin 1 nM 4.45110128919084 0.000340750641517429 yes 72 4.27155158591344e-06 45 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_431 k089-0097 107 µM 4.4449236407648 0.000346635283731694 yes 73 4.39615451776237e-06 13 5499420 SGTC_690 glyoxal 20.3 µM 4.43757937269713 0.000353754066540269 yes 74 4.54880895517594e-06 22 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_576 1073-0113 22.7 µM 4.42661616156933 0.000364633785858463 yes 75 4.78614221310915e-06 35 5439563 SGTC_2466 5983409 37.09 µM 4.36333509745459 0.000433750250675821 yes 76 6.40472519506991e-06 8 2879657 SGTC_2675 theaflavin digallate 100 µM 4.28045939078288 0.000542678149342898 yes 77 9.32539594923041e-06 6 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_1271 0832-2808 169 µM 4.22311853476205 0.000632298876245151 yes 78 1.20472508083878e-05 5 3663794 SGTC_1074 carmofur 3.8 µM 4.21325400588346 0.000649029365741763 yes 79 1.25858856069908e-05 25 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_905 2-aminofluorene 215 µM 4.17640977362321 0.000715196450391481 yes 80 1.48073065234259e-05 4 1539 An established DNA mutagen. YPR165W RHO1 SGTC_1786 berberine 21.6 µM 4.16153599799731 0.000743627596585677 yes 81 1.58057077102758e-05 14 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1573 oleylamine 1.06 µM 4.13525277783091 0.000796427145371562 yes 82 1.77282068312604e-05 2 5356789 An amine of the fatty acid oleic acid. SGTC_1655 st012546 55.1 µM 4.09317484807116 0.000888184109139072 yes 83 2.12753305229361e-05 5 720985 YLR208W SEC13 SGTC_1133 3473-0247 50 µM 4.09194894769045 0.000890997530074666 yes 84 2.13881418944888e-05 42 711311 SGTC_2275 7947463 200 µM 4.09153364335916 0.00089195250274534 yes 85 2.14264880787092e-05 10 1225414 SGTC_2090 5301565 104.445 µM 4.06895598829911 0.000945307008210096 yes 86 2.36121329163212e-05 5 2056344 SGTC_299 1273-0059 1.44 µM 4.0627085387338 0.000960580054082099 yes 87 2.42532900695084e-05 8 2848077 SGTC_2996 9066192 71.4286 µM 4.05898685323386 0.000969785769840145 yes 88 2.46430440094229e-05 7 6472854 SGTC_3055 9094636 49.47 µM 4.04540745867683 0.00100406609246716 no 89 2.61160981078049e-05 7 25236176 SGTC_851 0394-0702 453 µM 4.04112236470527 0.00101511220130405 no 90 2.6597995241805e-05 21 762646 SGTC_1341 1486-1360 280 µM 4.03951993302554 0.0010192715136739 no 91 2.6780358103299e-05 5 3976547 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 4.02762649759765 0.0010506345114743 no 92 2.81713775640843e-05 6 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_1781 st038725 66.3 µM 4.00090077477273 0.00112436471702073 no 93 3.15509078759799e-05 12 4270275 YIL048W NEO1 SGTC_2446 5162541 200 µM 3.9912181358479 0.00115222632547972 no 94 3.28673913051074e-05 4 1549321 SGTC_1818 st052136 56.3 µM 3.9722122758928 0.00120876222638496 no 95 3.56041100356761e-05 15 674169 SGTC_354 2783-3500 4.88 µM 3.9656860338914 0.00122875376443227 no 96 3.65925726175106e-05 27 6740761 SGTC_584 0986-0246 15.4 µM 3.96539483078356 0.00122965280495757 no 97 3.66372774822401e-05 26 53315 YDR232W HEM1 SGTC_1754 st042065 16.137 µM 3.95583726197134 0.00125949636784603 no 98 3.81335339439811e-05 32 1126236 YIL048W NEO1 SGTC_2041 5107442 45.335 µM 3.93074833383264 0.00134101610728386 no 99 4.23409382078693e-05 31 793005 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 3.92406645683772 0.00136352561142782 no 100 4.35333501411642e-05 4 688798 SGTC_2378 9074213 121.43 µM 3.92334508712894 0.00136597625084667 no 101 4.36639626959017e-05 19 657714 SGTC_1843 st055809 45.5 µM 3.89614530153089 0.0014613683096507 no 102 4.88678839296586e-05 5 16413835 SGTC_1930 st074634 34.3 µM 3.83258713035876 0.00170841877799884 no 103 6.3401333130748e-05 17 684253 YOR116C RPO31 SGTC_2053 5265679 138 µM 3.82974044465749 0.00172032550997891 no 104 6.41392447537961e-05 7 764595 SGTC_1643 st009866 20.2 µM 3.81041461367345 0.00180317647036448 no 105 6.93669619296377e-05 25 3156273 YOR207C RET1 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 3.77764048578958 0.00195201421310157 no 106 7.91606002804134e-05 3 676296 Flavone; oxidizing agent. SGTC_1735 st034310 56.75 µM 3.75550909127117 0.00205874135603628 no 107 8.64947405709715e-05 11 871153 SGTC_1840 st055363 71 µM 3.74679302243068 0.00210220769674283 no 108 8.95548764208029e-05 3 676033 SGTC_2567 aureobasidin a 60 nM 3.72451064904869 0.0022171379636039 no 109 9.78472259888366e-05 49 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_1723 st034307 2.5525 µM 3.71075878038143 0.00229088061025971 no 110 0.00010331946878167 18 867466 SGTC_952 1185-0122 232 µM 3.70736406981815 0.00230942289501826 no 111 0.000104713881097208 6 678600 SGTC_1884 5633444 25 µM 3.68592209291972 0.00242971503432266 no 112 0.000113938029322025 18 5724239 SGTC_2576 guaiol 23.12 µM 3.68458880821411 0.00243737887349782 no 113 0.000114536073537209 9 227829 SGTC_1631 benzylvanillin 81.9 µM 3.67501648435819 0.00249304666866976 no 114 0.00011891702912097 9 75506 SGTC_1541 2',3',6-trimethoxyflavone 64 µM 3.65750374017863 0.0025978759718745 no 115 0.000127341772169415 7 688801 SGTC_351 caspofungin 25 nM 3.64760243022685 0.00265889119534585 no 116 0.000132349399434523 36 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_960 1222-0186 7.7 µM 3.64259724788498 0.00269022472036987 no 117 0.000134950480093325 12 3126296 SGTC_1537 2',6'-dihydroxyflavanone 78 µM 3.63477889358304 0.00273983686927997 no 118 0.000139109571203409 9 5106787 A p450 inhibitor. SGTC_2507 purpurin 79.67 µM 3.63412119829875 0.00274404776604929 no 119 0.000139464865030076 9 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_1959 st077091 55.8 µM 3.58465348384039 0.00307801374372969 no 120 0.000168763014997773 27 821356 YKL052C ASK1 SGTC_2396 5342950 42.78 µM 3.56791809132024 0.00319902365440725 no 121 0.000179914471263063 43 1886677 SGTC_1377 2944-0135 198 µM 3.52767360383486 0.00350772705655008 no 122 0.000209614375924585 10 1894137 SGTC_314 1671-0008 2.74 µM 3.51763215875867 0.00358880834409828 no 123 0.000217707736572902 13 3913060 SGTC_1363 1636-0063 10.4 µM 3.50829939163441 0.00366567149393861 no 124 0.000225490606762946 12 6072185 SGTC_580 1123-0028 41 µM 3.50131469288162 0.00372415920280219 no 125 0.000231484405223647 30 1677248 YPR107C YTH1 SGTC_859 0439-0102 54.6 µM 3.5004085317804 0.00373180813362975 no 126 0.00023227281519493 16 610143 SGTC_161 4065-0411 162.148 µM 3.48690415934375 0.00384748040304285 no 127 0.000244323217891643 13 1906281 YLR208W SEC13 SGTC_1248 0469-0687 58.6 µM 3.4777659252585 0.00392756679942345 no 128 0.000252805622282526 12 4017482 SGTC_1550 gossypolone 36.6 µM 3.45020848291959 0.00417819604169771 no 129 0.000280076890730782 8 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2163 5671233 125 µM 3.44192309305662 0.00425629803862451 no 130 0.000288797218724712 18 701023 SGTC_1615 st002656 86.5 µM 3.41823356209105 0.00448685818111589 no 131 0.000315144972016168 8 1584458 SGTC_1101 ebselen 5.29 µM 3.40619610402991 0.00460823474427806 no 132 0.00032937421571946 10 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_457 grayanotoxin iii 135 µM 3.40026055244015 0.00466915622440034 no 133 0.000336608350136414 24 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_13 0199-0087 65 µM 3.39948706426628 0.00467714786650025 no 134 0.000337561866354037 8 4589825 SGTC_2472 5377652 49.4 µM 3.3973231337595 0.00469957035486971 no 135 0.000340242803574871 18 1610903 SGTC_607 4491-0986 66.8 µM 3.37496479592208 0.00493692059235546 no 136 0.000369125669933255 10 698981 YDR232W HEM1 SGTC_2400 5203494 178.7 µM 3.33966651429891 0.00533341722939745 no 137 0.000419395243046125 26 6777674 SGTC_3202 9113761 49.47 µM 3.3285954240753 0.00546348149626258 no 138 0.000436425489673331 21 4798415 SGTC_2474 5321570 43.32 µM 3.31464032995349 0.00563143862567718 no 139 0.000458805543485531 8 2841384 SGTC_2534 helenine 20.12 µM 3.30536644716906 0.00574557561987828 no 140 0.000474261482845833 30 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_2694 st077685 81.9 µM 3.2914376414316 0.00592086088449985 no 141 0.00049838356361395 9 2838096 SGTC_1360 1598-0022 39.8 µM 3.27779108955036 0.00609717677479535 no 142 0.000523113977428093 20 761525 SGTC_1800 st050079 29.0735 µM 3.26556325714372 0.0062590983303044 no 143 0.000546233008507001 38 3645560 SGTC_374 0880-0231 82.3 µM 3.25672586264031 0.00637848247895624 no 144 0.000563526120523527 14 6833587 SGTC_423 5-fluorouracil 457 µM 3.2223325873863 0.0068625025712677 no 145 0.000635757234389965 45 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2128 5255449 168.493 µM 3.22090459027125 0.00688328224336134 no 146 0.000638933408048768 18 736008 SGTC_101 0490-5701 117.494 µM 3.21057692072055 0.00703522782068625 no 147 0.000662344047880372 8 4661669 SGTC_919 tnp00227 403.569 nM 3.20828412338107 0.00706935937990807 no 148 0.000667647559986902 17 1269246 A methoxyflavone. YNL221C POP1 SGTC_1668 st014914 51.6 µM 3.1980185466436 0.00722397525012541 no 149 0.000691876902571364 15 2839556 SGTC_825 1988-2224 89.6 µM 3.19568926644643 0.00725947024466888 no 150 0.000697486285237337 16 1180859 SGTC_3047 9092122 49.47 µM 3.19297767741471 0.00730098473381925 no 151 0.000704069157881563 11 17173831 SGTC_442 cape 100 µM 3.17788793919799 0.00753585397063247 no 152 0.000741760384876953 4 5281787 SGTC_1982 st072467 71.9 µM 3.17435440475097 0.00759180514652025 no 153 0.000750851042523099 15 3163533 SGTC_330 1488-0319 80.1 µM 3.17234536248935 0.00762377984798075 no 154 0.000756065325835978 18 6846614 SGTC_2845 9003024 42.97 µM 3.16306752538284 0.00777298336351229 no 155 0.000780580579926755 22 2990173 SGTC_2522 biochanin a 4.94 µM 3.15088200488651 0.00797284765513817 no 156 0.000813891184050888 14 5280373 A possible chelator. SGTC_2389 9091542 195.52 µM 3.1421922203496 0.0081181223890593 no 157 0.000838439542693095 11 3626624 YOL127W RPL25 SGTC_1313 1220-0047 237 µM 3.1191356455292 0.00851491061853888 no 158 0.000906912187396147 13 3528706 SGTC_2417 cerulenin 830 nM 3.11357597470781 0.00861309815218294 no 159 0.000924174576588181 22 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_916 4466-0038 42 nM 3.11163502893748 0.00864760969235549 no 160 0.000930271821219497 38 5722064 YGL116W CDC20 SGTC_97 0535-0701 19.132 µM 3.1051118554899 0.00876448716660913 no 161 0.000951035398465468 18 2832013 YGL099W LSG1 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 3.07950480880176 0.00923678865089542 no 162 0.00103672511542425 19 368090 SGTC_2363 9053361 176 µM 3.07695960938017 0.00928492810844417 no 163 0.00104561817608924 22 6469797 YMR079W SEC14 SGTC_1698 5-fluorocytosine 1.055 µM 3.06276772816289 0.00955739605437111 no 164 0.00109650103072387 26 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1229 0139-0193 12.2 µM 3.04676068426141 0.00987307753233991 no 165 0.00115660899698822 32 3090752 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 3.04248240036627 0.00995897825573885 no 166 0.00117317768839788 24 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_2447 5741742 33.78 µM 3.02815650498953 0.0102513859553093 no 167 0.00123025311418455 20 1776504 SGTC_139 0099-0334 718.624 µM 3.00837003457635 0.0106675486874321 no 168 0.00131326558462548 18 97690 SGTC_1568 digitonin 820 nM 3.00161716484135 0.0108129091936429 no 169 0.00134274836262968 36 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_2974 9094440 9.66 µM 2.99244454775893 0.0110131164862534 no 170 0.00138376469728427 32 25236134 SGTC_2488 5268135 45.7 µM 2.9813809349743 0.0112588818143216 no 171 0.00143475802935489 22 1270356 YLR208W SEC13 SGTC_610 4215-0184 155 µM 2.97454691709319 0.0114130618181765 no 172 0.00146710790752938 35 5605015 SGTC_1686 st019653 115.5 µM 2.97253094244362 0.0114588925080837 no 173 0.00147677718865302 14 97252 SGTC_2092 5303694 80.6725 µM 2.96828344964062 0.0115559775224285 no 174 0.0014973401620722 20 1963699 SGTC_2525 harmine 47.85 µM 2.95911452270947 0.0117679899235586 no 175 0.00154262210897033 13 5280953 A monoamine oxidase inhibitor SGTC_3219 9131112 49.47 µM 2.95361790780144 0.0118966994304572 no 176 0.00157036302181837 35 17612988 YMR079W SEC14 SGTC_1510 1123-0200 71.5 µM 2.94571142524885 0.0120839796221319 no 177 0.00161106427895544 32 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_904 1141-0088 396 µM 2.94130564077147 0.0121894439541502 no 178 0.0016341593687988 13 1378119 SGTC_1356 1502-0781 85.8 µM 2.9390808087904 0.012243003786155 no 179 0.00164593617029587 14 567702 SGTC_197 4544-0043 41.561 µM 2.92977018543813 0.0124693627975403 no 180 0.0016960638718707 38 896523 SGTC_3061 glucosamine 200 µM 2.92913596849963 0.0124849128144901 no 181 0.00169952849894014 11 91431 and experimental redox chemotherapeutic SGTC_2241 6772625 37.8075 µM 2.90189671443403 0.0131688146115617 no 182 0.00185455404697541 23 2285411 SGTC_2677 mitomycin C 100 µM 2.90147273919932 0.0131797103700493 no 183 0.00185706546976321 9 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1530 rhein 70.4 µM 2.89833026504222 0.0132607120606725 no 184 0.00187577654994091 14 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_1772 st048439 82.2 µM 2.88672186173414 0.0135636746126688 no 185 0.00194639093322156 16 2927068 YDL195W SEC31 SGTC_1124 fisetin 1.16336 µM 2.88108458362715 0.0137129419994457 no 186 0.00198154635591128 21 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_2242 6630449 61.2675 µM 2.87986673767073 0.0137453743928947 no 187 0.0019892164652424 12 691249 YDR170C SEC7 SGTC_3013 9080133 71.4286 µM 2.87982320099097 0.0137465350399725 no 188 0.0019894911617881 9 17050193 SGTC_555 4296-0685 37 µM 2.87621085026296 0.0138431319053895 no 189 0.00201240379523476 13 2908540 YHR072W ERG7 SGTC_436 n,n-dimethylsphingosine 3.3 µM 2.86262830028052 0.0142115956779727 no 190 0.00210071560797008 15 5282309 SGTC_945 3381-0768 11.3 µM 2.86236081486368 0.014218935976763 no 191 0.0021024895230093 17 1126236 YIL048W NEO1 SGTC_2700 st077718 96.8 µM 2.85113327331613 0.0145300002965099 no 192 0.0021781852980688 17 904970 SGTC_2440 5628896 157.78 µM 2.84707395872992 0.0146438982654613 no 193 0.00220615550941265 14 5522048 SGTC_184 1494-0393 24.714 µM 2.84649713678528 0.0146601451528152 no 194 0.00221015633692798 55 3090647 SGTC_17 0960-0276 49.807 µM 2.8339516337982 0.0150173605093047 no 195 0.00229881449758438 26 6821114 SGTC_1776 st049249 45.9 µM 2.8266816861701 0.0152277662073963 no 196 0.00235165273247123 29 1822314 SGTC_2829 7992743 58.44 µM 2.82342348997581 0.015322883151203 no 197 0.00237568824675834 16 16462845 SGTC_1464 k208-0027 110 µM 2.81757282054718 0.0154949634867813 no 198 0.00241940702993485 16 X1464 SGTC_2081 5214970 32.255 µM 2.80668615518415 0.015819580463213 no 199 0.00250269910525277 18 2063512 SGTC_282 k297-0036 65.7 µM 2.80045881543834 0.0160078755993706 no 200 0.00255150093098109 16 5061378 SGTC_1525 8-methoxypsoralen 92.5 µM 2.7898247661545 0.0163338577210787 no 201 0.00263682879670846 44 4114 Related to psoralen; DNA damaging agent. SGTC_3136 9095672 49.47 µM 2.78006369827202 0.0166380666738352 no 202 0.0027174118351664 21 17217380 SGTC_118 0083-0097 135.343 µM 2.77788612223971 0.0167065895604667 no 203 0.00273568949691034 43 5207356 SGTC_2808 7946468 45.46 µM 2.76835988388158 0.0170092020409292 no 204 0.00281696026302725 26 2970879 SGTC_3100 9120536 49.47 µM 2.76578284124015 0.0170918657275605 no 205 0.00283931680767246 18 16421196 SGTC_1384 3089-0840 101 µM 2.75478785950319 0.0174484196171708 no 206 0.00293651007489479 7 1069836 SGTC_2738 aclarubicin 5.55 µM 2.74320842179734 0.0178307740190676 no 207 0.00304210273928448 13 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_62 0180-0423 3.232 µM 2.73916435089503 0.0179659830502444 no 208 0.0030797786763334 32 30102 YGL099W LSG1 SGTC_3 0833-0587 95.581 µM 2.73672928776058 0.0180478176412363 no 209 0.0031026667195096 41 5382644 SGTC_838 0109-0203 71.4 µM 2.73048402540453 0.0182591546706613 no 210 0.0031620698983889 14 759422 SGTC_1677 st019204 53.9 µM 2.72875963365141 0.0183178775187978 no 211 0.00317865117693203 22 3945625 SGTC_511 blebbistatin 171 µM 2.72512201541012 0.0184422816970437 no 212 0.00321388640227754 19 3476986 A myosin inhibitor. SGTC_1817 st052116 64.4 µM 2.71991178886441 0.0186217210144277 no 213 0.00326496666604519 17 4361398 SGTC_805 3852-0218 479 µM 2.71096613802705 0.0189332745102128 no 214 0.00335437385476028 24 6615355 SGTC_2354 9060492 162 µM 2.7065972055673 0.0190870374298514 no 215 0.0033988339212585 17 6471895 SGTC_3144 9087057 49.47 µM 2.69921549240755 0.0193492465632451 no 216 0.00347515776914189 16 17249618 SGTC_2489 cantharidin 73.42 µM 2.69790550307017 0.0193960976310391 no 217 0.00348886223579502 29 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2617 dihydrotanshinone i 20.83 µM 2.68843905815056 0.0197375330851804 no 218 0.00358934689388284 47 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_1253 0550-0034 176 µM 2.65899134878558 0.0208324476713001 no 219 0.00391874877356124 35 5969915 SGTC_3000 9075062 71.4286 µM 2.63126217907271 0.0219100463573597 no 220 0.00425341910765077 27 17057871 SGTC_2505 galangin 7.89 µM 2.62932769815122 0.0219869484249559 no 221 0.00427769371816783 30 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1524 corynanthine 62.1 µM 2.61822226896332 0.0224328486054236 no 222 0.0044194605254589 31 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_738 1315-0003 72.4 µM 2.60706896393169 0.022888322884966 no 223 0.00456604827951873 20 6251474 SGTC_1422 4031-0024 15.5 µM 2.60109139538179 0.0231356227308984 no 224 0.0046463846499342 32 782427 SGTC_389 tpck 16.7 µM 2.59179321021893 0.0235247703551897 no 225 0.00477385711104081 20 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_1679 SEC14.276 6.7 µM 2.58908417658243 0.0236391793407795 no 226 0.0048115783822877 55 1005053 YMR079W SEC14 SGTC_749 1000-0129 128 µM 2.57847425329979 0.0240917768630504 no 227 0.00496188473671298 18 708470 SGTC_574 1315-0397 40 µM 2.56837990709703 0.0245291170032499 no 228 0.00510875544047996 31 6794277 SGTC_1627 st003713 25.6 µM 2.56313376880973 0.024759026230285 no 229 0.00518660368231738 27 16195070 YER133W GLC7 SGTC_1103 duloxetine 36.1 µM 2.56234508290464 0.0247937457831913 no 230 0.0051983979435605 32 60835 A selective serotonin reuptake inhibitor. SGTC_1720 st037298 9.481 µM 2.55981541060242 0.0249053827565173 no 231 0.00523638866595554 28 597396 SGTC_384 k007-0144 5.16 µM 2.54716011287438 0.0254702216818386 no 232 0.00543017954386806 49 6824886 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 2.51793446760759 0.0268157314107491 no 233 0.00590226409306948 33 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 2.50085539053189 0.0276291504895907 no 234 0.00619468780556531 33 165521 SGTC_1082 camptothecin 424.86 nM 2.49841184604976 0.0277471929034408 no 235 0.00623755828999191 47 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_3016 9080866 49.47 µM 2.49711706318538 0.0278099112419031 no 236 0.00626038078071891 26 17066299 SGTC_58 0957-0393 9 µM 2.48558660912594 0.0283736642636634 no 237 0.00646690554267531 84 6997992 SGTC_535 2293-4129 48.2 µM 2.45822347356 0.0297496610357843 no 238 0.00698131295729418 38 396118 YIL048W NEO1 SGTC_517 1365-0151 113 µM 2.4540430600775 0.0299646766414515 no 239 0.00706300325657962 33 768657 SGTC_3106 9121286 49.47 µM 2.44858535177254 0.0302473267449283 no 240 0.00717092229174588 23 15943471 SGTC_104 0074-0074 590.992 µM 2.44543459499203 0.0304115054581548 no 241 0.00723388436767654 48 3943124 SGTC_2750 bromebric acid 70.15 µM 2.43286397034014 0.0310738977808152 no 242 0.0074899637380819 39 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_2986 9022445 71.43 µM 2.43198672037233 0.0311205654702282 no 243 0.00750812892711115 30 6459286 SGTC_3075 9116269 49.47 µM 2.42826456132935 0.0313192211923128 no 244 0.00758563591900219 32 17015205 YNL244C SUI1 SGTC_3236 9132701 49.47 µM 2.4244632665157 0.0315231816483814 no 245 0.00766551711780658 30 24282524 SGTC_2186 6124449 200 µM 2.41587569858096 0.0319879958634224 no 246 0.00784870953802606 44 3834182 YLR033W RSC58 SGTC_2778 tioconazole 65.09 nM 2.4156595636494 0.0319997670984788 no 247 0.00785336945554529 70 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_697 0508-1955 564 µM 2.41416067829769 0.0320814985014018 no 248 0.00788575277585251 18 6243113 SGTC_397 arbidol 50 µM 2.39805420627799 0.0329706787611404 no 249 0.00824121293789654 27 131410 A RNA synthesis inhibitor. SGTC_3112 9123419 49.47 µM 2.38681481833704 0.0336031190071115 no 250 0.00849752470669152 36 17015854 SGTC_2776 terbinafine 19.92 µM 2.37705437568042 0.0341604082104456 no 251 0.00872575766139925 35 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_629 3448-6466 76.7 µM 2.3764417810925 0.0341956372696412 no 252 0.0087402598443321 20 573744 SGTC_1399 3562-5772 25 µM 2.37515079266566 0.034269977162479 no 253 0.00877089110926754 32 23847490 SGTC_2969 9091408 28.7 µM 2.36575695619583 0.0348149177894158 no 254 0.00899662610438207 37 4286311 SGTC_1089 terbinafine 2.25 µM 2.35868829724808 0.0352296479792295 no 255 0.00916982648468043 28 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_709 3807-1509 243 µM 2.34995488273254 0.0357476401743267 no 256 0.00938784337232984 48 1886677 YPL242C IQG1 SGTC_3277 9138724 49.47 µM 2.34826675885411 0.0358484816954794 no 257 0.00943050390670232 32 15943418 SGTC_2153 5569715 200 µM 2.34809792197416 0.0358585801187726 no 258 0.00943477989117406 34 2054701 SGTC_1892 st058411 7.36 µM 2.34412990108255 0.0360965860783854 no 259 0.00953576387338371 33 3934738 SGTC_3153 9100258 49.47 µM 2.34336393864543 0.0361426779237412 no 260 0.00955536564391308 25 25236848 SGTC_2942 9052777 62.25 µM 2.33873851747334 0.0364220381825087 no 261 0.00967448520988307 51 6469503 SGTC_809 3998-0021 90 µM 2.33476890382186 0.0366631966043664 no 262 0.00977774824740032 41 715485 SGTC_1282 0886-0010 32.4 µM 2.33458836553996 0.0366741954829434 no 263 0.00978246746089182 54 2836211 YNL267W PIK1 SGTC_2775 cyproheptadine 69.59 µM 2.32633239557151 0.0371800623121986 no 264 0.0100004125417932 32 2913 A selective serotonin reuptake inhibitor. SGTC_2773 thioridazine 9.09 µM 2.32466447539624 0.0372829497013086 no 265 0.010044954125415 25 5452 An antipsychotic. SGTC_2685 mycophenolic acid 18.85 µM 2.32046461133855 0.0375430532382059 no 266 0.0101578785858981 18 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2543 pimpinellin 60.67 µM 2.31993682995657 0.0375758440366052 no 267 0.0101721474235515 24 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_2508 celastrol 40.54 µM 2.31201984851403 0.0380705344928111 no 268 0.0103882947647712 21 122724 Celastrol is a natural product and antioxidant. SGTC_2746 daunorubicin 9.88 µM 2.31003251278254 0.0381955432437205 no 269 0.0104431770909744 12 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1106 tegaserod maleate 11.7 µM 2.30231940587729 0.0386838927770701 no 270 0.0106585831190862 35 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_977 1348-1378 135 µM 2.29589250412338 0.0390946817875788 no 271 0.0108410142260391 37 X977 SGTC_669 0108-0021 26.2 µM 2.29045540228297 0.0394449722500602 no 272 0.0109974655246431 43 17201 SGTC_2578 7,8-dihydroxyflavone 64.44 µM 2.28905734096751 0.0395354551718492 no 273 0.0110380104842803 30 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_1268 0828-0275 2.46 µM 2.28289323061715 0.0399364132313683 no 274 0.0112183291682259 33 745337 SGTC_1211 1056-0033 32.3 µM 2.27981440242793 0.0401379164797575 no 275 0.0113093492221388 29 6741922 SGTC_2337 9009472 200 µM 2.27484966011304 0.0404645882984523 no 276 0.0114574750129455 42 5742383 SGTC_1001 4048-4355 44.4 µM 2.27385561705071 0.04053025334779 no 277 0.0114873344877767 56 21824233 SGTC_1386 3228-0095 33.8 µM 2.27191977449897 0.0406583805724879 no 278 0.011545678154678 37 870181 SGTC_2088 5278280 127.392 µM 2.27113650507694 0.0407103159956248 no 279 0.011569357857364 30 791502 SGTC_2348 9022543 33.42 µM 2.25938925383949 0.041495706426213 no 280 0.0119295911368715 79 3162678 YDL140C RPO21 SGTC_883 0850-0245 24.6 µM 2.25678046341535 0.0416717788119188 no 281 0.0120108980437695 48 6823229 YPR165W RHO1 SGTC_3132 9126706 49.47 µM 2.25593435117867 0.0417290143801415 no 282 0.0120373714113948 38 850858 SGTC_90 0870-0863 4.608 µM 2.25472771364374 0.0418107479387285 no 283 0.0120752125016256 42 1738164 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 2.25313338233337 0.0419189413254283 no 284 0.0121253701056001 37 5357218 A potent inhibitor of glutathione S-transferases. SGTC_181 1447-1644 8.07 µM 2.25288665389708 0.0419357048719403 no 285 0.0121331482880281 48 534600 SGTC_1471 k673-0312 37 µM 2.24485958643138 0.0424840575048958 no 286 0.01238857403465 25 24099884 SGTC_2611 pyromycin 23.93 µM 2.24273400677941 0.0426302291375198 no 287 0.0124569861555904 36 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_3056 9094900 49.47 µM 2.24160044840774 0.0427083476473382 no 288 0.0124936034886672 35 25236784 SGTC_2748 diazoxide 86.69 µM 2.22928084279175 0.0435648305657395 no 289 0.0128976122357998 12 3019 A potassium channel activatior. SGTC_363 0455-0021 3.06 µM 2.22572463328782 0.0438146271770937 no 290 0.0130163158608735 61 4597466 SGTC_266 formosanin C 406 nM 2.22275775788688 0.044023910521748 no 291 0.0131160694554401 61 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_1104 tacrolimus 29.8 µM 2.22240587714805 0.0440487855671726 no 292 0.0131279442592368 50 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_3288 9119690 36.221 µM 2.20710710076948 0.0451412849843 no 293 0.0136532889105861 55 17595618 YKL019W RAM2 SGTC_1375 2910-0797 186 µM 2.20292086799041 0.0454439969926521 no 294 0.0138001632609155 37 742508 SGTC_2612 dictamnine 15.46 µM 2.19921566728122 0.0457132848840047 no 295 0.0139312954138109 74 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_2061 5245884 80.95 µM 2.19625206155199 0.0459295968735402 no 296 0.0140369534448574 31 573863 SGTC_1420 4'-methoxyflavone 42 µM 2.19527340088861 0.0460012091578797 no 297 0.0140719958744129 24 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_2736 butenafine 14.65 µM 2.18719963041862 0.0465954255181878 no 298 0.0143639769325848 42 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1780 st038448 24.544 µM 2.18712431568017 0.0466009974206882 no 299 0.0143667250018094 44 728868 YDL195W SEC31 SGTC_1523 st012844 44.7 µM 2.18501900745192 0.0467569679126783 no 300 0.0144437264840891 30 4274103 SGTC_2894 9048625 32.47 µM 2.18253551119496 0.0469414943233145 no 301 0.0145350166895826 52 4092861 SGTC_2323 6148992 148.28 µM 2.18182723077273 0.0469942272056733 no 302 0.0145611430261479 40 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_1402 3909-7673 35.9 µM 2.18092563909436 0.0470614212018997 no 303 0.0145944584927433 36 5328014 SGTC_171 k064-0041 9.68 µM 2.1702126467304 0.0478657509321986 no 304 0.0149953702290107 42 53325 SGTC_402 epigallocatechin gallate 10 µM 2.16924846319322 0.0479386782575957 no 305 0.0150319128010293 55 65064 An antioxidant. SGTC_2375 9072683 200 µM 2.16397259266026 0.0483393020409209 no 306 0.0152332264503219 41 16798029 SGTC_1115 galangin 695.678 nM 2.16245476477966 0.0484550531786899 no 307 0.0152915701090279 32 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_3158 9100007 49.47 µM 2.16186917115394 0.0484997703716593 no 308 0.0153141309433655 33 19297233 SGTC_1329 1447-1697 50.6 µM 2.15998704774111 0.0486437168856802 no 309 0.0153868361321603 34 2840515 SGTC_304 1310-0298 97 µM 2.15782635176341 0.0488093897704743 no 310 0.0154706676270165 43 1550234 SGTC_971 1315-0384 26.7 µM 2.15766653023111 0.0488216620882957 no 311 0.0154768839861586 40 6769120 SGTC_698 k064-0052 127 µM 2.15621960410944 0.0489328803808447 no 312 0.0155332607315102 30 5088751 SGTC_2754 granisetron 64.02 µM 2.15513875088107 0.0490160924164711 no 313 0.015575489061419 44 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_3224 9130643 49.47 µM 2.15410131608525 0.0490960680681419 no 314 0.0156161136814905 47 17644395 SGTC_3278 9139605 49.47 µM 2.14961396657972 0.0494431981445797 no 315 0.0157928813661461 52 7958859 SGTC_172 1112-0046 2.638 µM 2.1493602217152 0.0494628855853202 no 316 0.0158029280577267 35 2802135 YIL048W NEO1 SGTC_3097 9117246 49.47 µM 2.14491659538116 0.0498086709600476 no 317 0.0159797580593597 30 16423892 SGTC_347 4534-1311 26.2 µM 2.13764225276838 0.0503788908041026 no 318 0.0162728948348773 33 2862016 SGTC_3007 9078383 71.4286 µM 2.13714630600163 0.0504179556329937 no 319 0.0162930468229357 47 6496995 SGTC_99 0109-0120 622.8 µM 2.13615384756821 0.0504962022636636 no 320 0.0163334379433383 38 759414 SGTC_2662 daunorubicin 22.37 µM 2.13597092570865 0.0505106345992276 no 321 0.0163408918574362 56 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1934 st074720 32.6 µM 2.13327318145114 0.050723865528377 no 322 0.0164511614415364 58 17250992 SGTC_2248 tofa 1.1 µM 2.13307808231059 0.0507393140065786 no 323 0.0164591607106498 77 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_795 0685-0265 78 µM 2.12954576140823 0.0510196612753913 no 324 0.0166045665125982 69 302754 SGTC_12 0849-0099 9.267 µM 2.12592203659811 0.0513085426732125 no 325 0.0167548758399548 40 6071388 SGTC_3279 9140807 49.47 µM 2.12120180056115 0.0516867870292182 no 326 0.0169524119096473 28 45595718 SGTC_327 1273-0057 3.96 µM 2.11751620421219 0.0519836614723371 no 327 0.0171080307638744 49 3108138 SGTC_2784 7567673 72.73 µM 2.1163772508683 0.0520756775821699 no 328 0.0171563676487683 50 3471247 SGTC_1932 st074806 40.9 µM 2.11622194313755 0.0520882349216238 no 329 0.0171629679018008 52 17251235 SGTC_2104 5389443 200 µM 2.11582601899109 0.0521202580796572 no 330 0.0171798036650534 52 2244536 SGTC_1907 st060210 83.7 µM 2.10911826546897 0.0526651752910716 no 331 0.0174671873087407 52 688793 SGTC_1137 ixabepilone 100 µM 2.10147132464752 0.053291893279685 no 332 0.0177998063106684 54 154225 A novel microtubule stabilizer. SGTC_1802 st050112 57.9 µM 2.09344043395235 0.0539564275711263 no 333 0.0181549280792212 38 4662563 SGTC_3116 9124943 49.47 µM 2.08508276937434 0.0546549501114257 no 334 0.0185308940179011 45 41905195 YPL160W CDC60 SGTC_2405 ticlatone 3.52 µM 2.08385964978613 0.0547577739216554 no 335 0.0185864677962233 54 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_572 0960-0087 17.7 µM 2.08374048025837 0.0547678002984807 no 336 0.0185918899721406 65 6796365 SGTC_493 zm226600 134 µM 2.07888943450864 0.0551771783684962 no 337 0.0188137570240157 54 5240098 A potassium channel opener. YCR052W RSC6 SGTC_168 3970-0862 530.542 µM 2.07789087991157 0.0552617452811672 no 338 0.018859705358982 114 3135186 SGTC_3265 9137266 49.47 µM 2.0761922589842 0.0554058354773245 no 339 0.0189380864730425 22 17224265 SGTC_1662 st014054 52 µM 2.07387404898254 0.0556029625318507 no 340 0.0190455048771512 26 2838777 SGTC_1547 harmine 94.2 µM 2.07284058153035 0.0556910207920567 no 341 0.0190935591579073 64 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_268 camptothecin 39.6153 µM 2.06552914486362 0.0563171508752713 no 342 0.0194364804133339 108 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2697 mebhydrolin 72.4 µM 2.06424240150815 0.0564279158674214 no 343 0.0194973695536273 47 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_2680 butyl paraben 22.24 µM 2.06283256856939 0.0565494736598499 no 344 0.0195642692717531 34 7184 An antifungal and steroid mimetic. SGTC_836 0330-0104 1.35 µM 2.06232049715414 0.0565936762311934 no 345 0.0195886164174693 44 46494820 SGTC_1765 st044815 90.4 µM 2.05988398151752 0.0568043720038394 no 346 0.0197048167062563 59 645695 SGTC_3152 9099253 49.47 µM 2.05906951937784 0.0568749395889448 no 347 0.0197437896345053 90 25236131 SGTC_3254 9136651 49.47 µM 2.0552598580405 0.0572059378574408 no 348 0.0199269561608948 54 16454030 SGTC_3029 9088683 49.47 µM 2.0484499585657 0.0578013837841992 no 349 0.0202579653130012 44 25236615 SGTC_2079 5212404 121 µM 2.04434955138456 0.0581622599563698 no 350 0.0204595136587016 43 758462 SGTC_1346 1488-2224 62.4 µM 2.03765518946145 0.0587552311447932 no 351 0.0207922142588975 61 3722427 SGTC_1936 st074407 74.3 µM 2.0375185319259 0.0587673851893389 no 352 0.0207990533812856 61 809813 SGTC_1834 st055981 52.8 µM 2.03694075681826 0.0588187931460674 no 353 0.0208279895956979 53 471719 YDL150W RPC53 SGTC_1168 k815-0004 80.5 µM 2.03596737617758 0.058905480192139 no 354 0.0208768156571961 72 642433 SGTC_718 1130-0073 349 µM 2.03347926838556 0.0591275209974176 no 355 0.02100206300385 49 6740020 SGTC_1004 4084-0029 199 µM 2.02514745443903 0.0598758413619804 no 356 0.0214261126755088 36 716894 YLR208W SEC13 SGTC_78 0336-0123 156.75 µM 2.01997565370572 0.0603440643350345 no 357 0.0216929564845965 43 6765896 SGTC_970 1315-0089 19.5 µM 2.01181744504439 0.0610884777351126 no 358 0.0221195921521781 50 6811083 YLR033W RSC58 SGTC_3235 9132602 49.47 µM 2.00971845646698 0.0612811606752557 no 359 0.0222304977120759 52 4912240 SGTC_1767 st044992 70.3 µM 2.00912281856189 0.0613359254455381 no 360 0.0222620551339547 41 9600693 SGTC_1479 0549-0158 134 µM 2.00911212509662 0.061336908984698 no 361 0.02226262202837 49 5440202 SGTC_2068 5226020 147 µM 2.00798204544938 0.0614409183446859 no 362 0.022322599818241 58 1810509 SGTC_1017 4239-0030 168 µM 2.00610835183892 0.0616136713487907 no 363 0.0224223444911125 51 1149593 SGTC_3246 9135460 32.98 µM 2.00050303330701 0.0621327421709812 no 364 0.0227229863523192 41 41446951 SGTC_994 3910-0338 138 µM 1.99974754290573 0.0622029631791802 no 365 0.0227637657922282 73 3479481 SGTC_1300 1094-0077 113 µM 1.99663281753085 0.0624931232966549 no 366 0.0229325425604335 48 5532636 SGTC_1687 st020778 55.3625 µM 1.99397814395761 0.0627412581618327 no 367 0.0230772215379196 49 4259299 SGTC_1364 1653-0028 37.6 µM 1.99298485413522 0.062834299050063 no 368 0.0231315528022953 35 5718652 SGTC_3018 9082602 49.47 µM 1.98626033680891 0.0634670108940652 no 369 0.0235022121475023 58 17332089 SGTC_1361 1608-0041 5.61 µM 1.98499059400863 0.0635870360168427 no 370 0.0235727589997171 52 X1361 SGTC_1340 1486-1359 257 µM 1.98215000173694 0.0638561885108816 no 371 0.0237312273270651 49 4309068 SGTC_1529 apigenin 74 µM 1.9760206013371 0.0644399811195468 no 372 0.0240762219831875 49 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_1156 4092-0367 4.88 µM 1.97319951594509 0.0647100640927203 no 373 0.0242364178072021 67 1357585 SGTC_2923 7992654 58.14 µM 1.97135472957741 0.064887153718593 no 374 0.0243416576657407 56 2985126 SGTC_1871 st057448 67.3 µM 1.97088710384192 0.0649321030080558 no 375 0.0243683952686811 60 691747 SGTC_1097 itavastatin 7.23 µM 1.9696713105085 0.0650490810522353 no 376 0.0244380265324935 72 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_111 0083-0039 52.457 µM 1.96900754077945 0.0651130149123441 no 377 0.0244761125769833 24 759313 SGTC_1841 st054148 70 µM 1.96776118933787 0.0652331943909834 no 378 0.0245477608366035 49 675442 SGTC_193 1273-0060 1.558 µM 1.95468338075055 0.0665046217014405 no 379 0.0253102264395768 47 2847393 YHR072W ERG7 SGTC_1284 0929-0043 16 µM 1.95338541979377 0.0666318490285841 no 380 0.025386971288038 56 1239883 SGTC_840 0245-0196 390 µM 1.95085222318908 0.0668806977907624 no 381 0.0255373137145889 40 3827528 SGTC_394 menadione 8.33 µM 1.95016818406965 0.0669480175601676 no 382 0.0255780382848564 58 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_151 3013-0144 2.285 µM 1.94438668577205 0.0675190996896563 no 383 0.0259244191029006 80 906558 YHR107C CDC12 SGTC_2057 5236571 38.335 µM 1.94374264154035 0.067582949121223 no 384 0.0259632468535189 59 54684039 YBR257W POP4 SGTC_1851 st056236 18.9 µM 1.94253579837439 0.0677027190712325 no 385 0.0260361352821271 54 5393171 SGTC_1049 3226-0134 66 µM 1.940821384019 0.0678731434066975 no 386 0.0261399731528974 53 5702385 SGTC_2224 6650123 117.647 µM 1.93916093976091 0.0680385183918254 no 387 0.0262408720907996 34 2908370 SGTC_202 3594-0513 34.79 µM 1.9349330386044 0.0684610084288816 no 388 0.0264992566373749 52 708429 SGTC_2052 5265182 7.135 µM 1.92109400230316 0.0698580927804927 no 389 0.0273599288079771 62 1239884 SGTC_1657 st012939 43.4 µM 1.90735261982031 0.0712669264372828 no 390 0.0282374702344486 33 24207257 SGTC_3023 9089636 49.47 µM 1.90591079545576 0.071416004731323 no 391 0.0283308900958348 41 17249241 SGTC_2351 9026858 72.31 µM 1.90229804387411 0.0717905984801877 no 392 0.0285661006401208 67 1409300 SGTC_2 0422-0095 29 µM 1.89996027024682 0.0720337960761293 no 393 0.0287191668145223 48 6790840 SGTC_828 2074-0507 139 µM 1.89361046093961 0.0726975517486081 no 394 0.0291383669811916 57 X828 SGTC_637 1181-0519 7.26 µM 1.88516142435025 0.0735879924624022 no 395 0.0297040235872423 72 6252091 YGR060W ERG25 SGTC_2983 9022671 12.99 µM 1.8838230050461 0.0737298098451385 no 396 0.0297944603431328 52 6405161 SGTC_1600 coumarin 106 71.1 µM 1.88002490588422 0.074133389723174 no 397 0.0300523418251652 50 100336 A hepatotoxic, DNA x-linker. SGTC_470 aa-861 153 µM 1.87769910211601 0.0743813576062287 no 398 0.0302111698142644 78 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_2643 anethole 100 µM 1.877667347956 0.0743847474843854 no 399 0.0302133430953813 59 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_2084 5306078 60.6385 µM 1.87765347596516 0.0743862284095383 no 400 0.0302142925466386 58 679340 SGTC_2866 9034245 58.44 µM 1.87343215237268 0.0748379286862591 no 401 0.0305043667945758 28 6462273 SGTC_2311 7694451 200 µM 1.87320087492206 0.0748627367283853 no 402 0.0305203257823445 85 2163142 SGTC_2174 5790901 200 µM 1.86810148020234 0.0754113202470262 no 403 0.0308739636405189 71 786020 SGTC_3077 9117319 49.47 µM 1.86718417608383 0.0755103264586202 no 404 0.0309379362970007 54 17154678 SGTC_3209 9113616 49.47 µM 1.86614996671198 0.0756220692112038 no 405 0.031010193435267 72 16649353 SGTC_780 0109-0199 192 µM 1.86152008741973 0.0761238566152939 no 406 0.0313353833121362 68 610414 SGTC_2977 9011197 71.43 µM 1.85949691334844 0.0763439228122676 no 407 0.0314783681829541 66 2704722 SGTC_1008 4106-0037 6 µM 1.85418130068574 0.0769244231787117 no 408 0.0318566131961347 64 2905394 SGTC_2411 st077133 39.94 µM 1.85403345373415 0.0769406168790061 no 409 0.0318671870254288 84 1403142 YNL221C POP1 SGTC_2516 gossypol 71.55 µM 1.85391976393865 0.0769530711028638 no 410 0.031875319949168 65 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2089 5281248 129.67 µM 1.84554969413082 0.0778741913366699 no 411 0.0324788083105605 68 2737878 SGTC_1196 1588-0294 184 µM 1.84502896415373 0.0779317725882043 no 412 0.0325166626934359 51 6144269 SGTC_2082 5219693 150 µM 1.84330031142162 0.0781231551117328 no 413 0.03264258785525 51 2834649 SGTC_1319 1306-0155 43.7 µM 1.84325851392645 0.0781277870045868 no 414 0.0326456376014803 71 3122360 SGTC_785 1270-0111 65.3 µM 1.84271074327599 0.0781885088205254 no 415 0.0326856273048178 60 6741994 SGTC_2633 5,7-dihydroxyisoflavone 100 µM 1.84211803207898 0.0782542527279877 no 416 0.0327289433607933 59 5377381 SGTC_2025 5147754 141 µM 1.83679246504931 0.0788468499162411 no 417 0.0331202693510089 45 315777 YLR208W SEC13 SGTC_1022 4477-0945 21.3 µM 1.83204288098266 0.0793782177884612 no 418 0.0334725160989794 54 4648966 SGTC_1625 st003711 30.1 µM 1.83144998166488 0.0794447392650884 no 419 0.0335167034515421 62 24207034 YER133W GLC7 SGTC_2342 7990637 118.86 µM 1.83012122875729 0.0795939744663029 no 420 0.0336159066038963 87 2033102 YER133W GLC7 SGTC_1424 4048-1941 275 µM 1.82661662461625 0.0799886017837977 no 421 0.0338787160031176 61 X1424 SGTC_1665 st014639 11.4 µM 1.82279099142705 0.0804210646972889 no 422 0.0341675263305231 64 981133 YIL048W NEO1 SGTC_263 alizarin 107.927 µM 1.81480600832467 0.0813294032742983 no 423 0.0347768633734739 94 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_2220 6782180 200 µM 1.8143380440659 0.0813828760472869 no 424 0.0348128489278802 29 833803 SGTC_1502 4534-4282 27.7 µM 1.81423209502266 0.0813949861849937 no 425 0.0348210004491242 49 3278949 SGTC_531 3788-1495 174 µM 1.81246634053788 0.0815970147661393 no 426 0.0349570851400624 55 2896655 SGTC_3232 9132874 49.47 µM 1.8119462922048 0.0816565880485218 no 427 0.0349972477869378 76 3784940 SGTC_2008 4012253 172 µM 1.8004157689989 0.0829858860188682 no 428 0.0358975063653941 71 603940 SGTC_635 k038-0028 24.7 µM 1.79742118944324 0.0833337646462254 no 429 0.0361343896556051 82 4035102 SGTC_3011 9081274 71.4286 µM 1.79629616915536 0.0834647405254507 no 430 0.0362237134025518 64 6625322 SGTC_1425 4048-4433 7.33 µM 1.79586921434411 0.0835144874686574 no 431 0.0362576598139235 65 23734946 SGTC_1135 dihydrocapsaicin 536.708 nM 1.79310281631021 0.0838373563415108 no 432 0.0364782427054139 57 107982 A Capsaicinoid. SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 1.78782208183374 0.0844562771634895 no 433 0.0369023585394307 77 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_2381 9035592 200 µM 1.78612949662953 0.0846553778630454 no 434 0.0370391466155747 59 4749657 SGTC_2890 9046729 58.44 µM 1.78554717138775 0.0847239587637996 no 435 0.0370863035630422 87 903329 SGTC_1842 st055362 61.2 µM 1.78319931535046 0.085000890285899 no 436 0.0372769319469321 49 676032 SGTC_1154 4088-0362 150 µM 1.78308998065896 0.0850138029153347 no 437 0.0372858285790547 67 6618304 SGTC_2927 9011802 47.9 µM 1.7782858984716 0.0855826265657537 no 438 0.0376784555887504 56 43912568 SGTC_3114 9122766 49.47 µM 1.77820037896679 0.0855927781916288 no 439 0.0376854753668909 61 17176985 SGTC_452 diindolylmethane 8 µM 1.77754243425864 0.0856709099274488 no 440 0.0377395177728635 51 3071 Inhibits expression of several cancer promoting factors. SGTC_2016 5121758 140 µM 1.77160504577478 0.0863783986598741 no 441 0.0382300707652469 94 2795203 SGTC_2496 diffractaic acid 79.83 µM 1.76930558484171 0.0866535688919479 no 442 0.0384214459697983 73 94870 An apoptosis inducer which activates caspases. SGTC_933 2914-0560 114 µM 1.7647803605238 0.0871970026578052 no 443 0.0388003433000705 60 463887 SGTC_471 1-acyl-paf 4 µM 1.75993028140423 0.0877822692521662 no 444 0.0392098141389804 70 16759367 SGTC_3281 9140613 49.47 µM 1.75910416981973 0.0878822488071897 no 445 0.0392799084017634 54 16013766 SGTC_2805 7950783 58.44 µM 1.75851248133982 0.0879539096560766 no 446 0.0393301748797984 72 1178958 YDL195W SEC31 SGTC_1911 st060208 74.3 µM 1.75790350819302 0.0880277093872644 no 447 0.0393819644092915 75 688783 SGTC_2147 5545932 89.7195 µM 1.75461093933711 0.0884275263298426 no 448 0.0396629395046243 81 797404 SGTC_1175 0741-0056 27.6 µM 1.75140606345244 0.0888179926828066 no 449 0.0399379946466656 69 765927 SGTC_69 0096-0274 206.684 µM 1.74460052848915 0.0896514008172641 no 450 0.0405272143927599 140 6741392 SGTC_3044 9093193 49.47 µM 1.74361815065522 0.0897721818030924 no 451 0.0406128480885988 75 25236277 SGTC_1474 0330-0125 5.35 µM 1.74179164467419 0.089997067761028 no 452 0.0407724546332232 56 X1474 SGTC_1487 3970-0795 2.82 µM 1.74134642328181 0.0900519484159159 no 453 0.0408114367034617 75 3765103 SGTC_1610 st001799 48.1 µM 1.72356425502847 0.0922642640112669 no 454 0.0423932680495593 59 621897 SGTC_2460 5552655 174.22 µM 1.7143608921476 0.0934249515473251 no 455 0.0432312331286717 91 5401989 SGTC_3128 9127691 49.47 µM 1.71058604010294 0.0939041257584186 no 456 0.0435787789080585 59 41316314 SGTC_995 3931-2021 34.6 µM 1.70536910728525 0.0945693378364093 no 457 0.0440628030909675 68 730143 SGTC_624 k048-0052 28 µM 1.69755718992175 0.0955719227270185 no 458 0.0447956842623193 68 6835531 SGTC_1960 st011366 51.8 µM 1.69597536574515 0.0957758835439217 no 459 0.044945272698471 84 3972846 SGTC_522 1273-0010 11.6 µM 1.6948354427775 0.0959230639017789 no 460 0.0450533209383291 88 5705015 SGTC_640 3381-0960 37.1 µM 1.69126852327703 0.0963846787223349 no 461 0.0453927644562925 84 1745025 SGTC_1778 st046819 58.9 µM 1.69054745926319 0.0964781936423961 no 462 0.0454616333432377 93 671715 SGTC_3290 9121031 71.43 µM 1.68901665792827 0.0966769444960417 no 463 0.0456081188613023 69 17014854 SGTC_672 1441-0018 53.7 µM 1.68588351857054 0.0970846714662105 no 464 0.0459091185085636 63 251141 SGTC_1357 1503-1303 39.5 µM 1.67970182705802 0.0978928166634533 no 465 0.0465076720701839 78 292895 SGTC_321 4534-3890 65.3 µM 1.67845504318196 0.0980564070602906 no 466 0.0466291499278256 82 699746 SGTC_1559 coumarin 343 70.1 µM 1.67655309742001 0.0983063469030784 no 467 0.0468149524709368 61 108770 A hepatotoxic, DNA x-linker. SGTC_1845 st056753 3.01 µM 1.67422483036854 0.0986129455857847 no 468 0.0470432106379549 71 5375839 SGTC_1408 3909-7976 48.8 µM 1.67307308581172 0.0987648719970434 no 469 0.0471564545749751 69 24152374 SGTC_1994 st072947 40.9 µM 1.66954072026621 0.0992318938463904 no 470 0.0475051336937222 71 5286565 YDL195W SEC31 SGTC_1260 0700-1617 7.75 µM 1.66531059307499 0.0997932905656367 no 471 0.0479254031105798 82 2853078 SGTC_1788 fluconazole 20 µM 1.66502613011773 0.0998311258445552 no 472 0.0479537713922563 86 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_3105 9121040 49.47 µM 1.66188207535774 0.100250002070286 no 473 0.0482682106723248 54 41448907 SGTC_1993 st073995 70.8 µM 1.66164390696447 0.100281784968416 no 474 0.048292097121304 84 3098394 SGTC_2676 harmalol 100 µM 1.65952114029694 0.100565387115197 no 475 0.0485054121725215 74 5459187 A monoamine oxidase inhibitor SGTC_1870 st057514 26.5 µM 1.65435650042406 0.101257826811635 no 476 0.0490275496573348 72 5393161 SGTC_879 0831-1030 162 µM 1.65083880367137 0.101731440369921 no 477 0.0493857471831561 111 1549252 SGTC_318 1488-0629 67.2 µM 1.64809111878027 0.102102501849173 no 478 0.0496669872562564 70 3662576 SGTC_1413 3910-0535 34.4 µM 1.64506648415409 0.102512101524598 no 479 0.0499780506789257 83 2876951 SGTC_1332 1480-0653 17.5 µM 1.64406896293209 0.102647448666886 no 480 0.0500809790646869 81 5749438 SGTC_1167 k781-0610 148 µM 1.64101036844282 0.103063259007409 no 481 0.0503976314589473 102 4525169 SGTC_2785 7756463 72.73 µM 1.63861979716723 0.10338910359272 no 482 0.0506462333435434 112 2201551 SGTC_3049 9092223 49.47 µM 1.6335891506219 0.10407724251141 no 483 0.0511725737178489 63 8623917 SGTC_2963 9082507 9 µM 1.63170529098644 0.10433578720438 no 484 0.0513707924617708 91 16459611 SGTC_339 3091-4833 71.4 µM 1.62995853790442 0.104575930702681 no 485 0.051555130138086 111 3240077 SGTC_1620 st003704 16.5 µM 1.62846720136334 0.104781276196583 no 486 0.0517129291800395 89 2834414 SGTC_1362 1611-0397 101 µM 1.62662232314784 0.105035705459471 no 487 0.0519086676185303 88 27816 SGTC_1199 1638-0010 4.46 µM 1.62540408852024 0.105203958544141 no 488 0.0520382426567307 81 3111136 SGTC_1163 k060-0048 49.9 µM 1.62403993690896 0.105392595911826 no 489 0.0521836426863529 76 6809982 SGTC_269 exalamide 29 µM 1.6213123405523 0.105770506344294 no 490 0.0524753348734112 87 3316 A derivative of salicylamide. SGTC_889 0919-1524 82.7 µM 1.6203796103136 0.105899961281049 no 491 0.0525753785356963 67 3905452 SGTC_273 hydroxyurea 18.1 mM 1.61249282225625 0.106999159362123 no 492 0.0534273703054395 102 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_2498 4'-Methoxychalcone 54.63 µM 1.60851805426197 0.107556239681066 no 493 0.0538608826584281 70 641818 YHR062C RPP1 SGTC_3244 9134489 49.47 µM 1.59749399226433 0.109112237613657 no 494 0.0550778178959636 94 16584271 SGTC_2328 6201408 200 µM 1.59472829224188 0.109505129837058 no 495 0.0553865042189713 106 2890418 SGTC_196 k015-0023 18.111 µM 1.59340079956942 0.109694072386551 no 496 0.0555351532342493 57 5211998 SGTC_1483 3453-0561 55.9 µM 1.59182662615844 0.109918428278364 no 497 0.0557118328481292 105 4546991 SGTC_848 0368-0089 85.6 µM 1.59178026942329 0.109925040166275 no 498 0.0557170424787271 80 762535 SGTC_2817 7995342 71.43 µM 1.58944898853811 0.110257920275757 no 499 0.0559795310376311 85 18879975 SGTC_2936 9038235 15.59 µM 1.5875698044415 0.11052677193562 no 500 0.0561918253568407 91 4749415 SGTC_1612 st002233 45.4 µM 1.58679281806203 0.110638071262478 no 501 0.0562797879871042 84 1035021 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 1.57959496200698 0.11167294755292 no 502 0.0570998268744273 104 5393153 SGTC_335 4077-0256 27.6 µM 1.57680799571861 0.112075499375835 no 503 0.0574198556536043 105 3121989 SGTC_134 0269-0018 6.916 µM 1.57557204882603 0.112254352252718 no 504 0.0575622309833851 99 4378915 SGTC_122 0236-0016 402.397 µM 1.57004012903189 0.113057371451393 no 505 0.0582028878751652 113 6808838 SGTC_3314 9135860 59.4275 µM 1.56996579616004 0.11306818952863 no 506 0.0582115344225096 74 25252478 SGTC_2274 7947094 46.08 µM 1.56560814133638 0.113703674841137 no 507 0.0587201914320457 87 2971028 SGTC_2561 acetosyringone 100 µM 1.5594156931393 0.114611104954796 no 508 0.0594490121842496 96 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_744 1594-0068 283 µM 1.55564689956523 0.115165893614186 no 509 0.0598960399298896 96 668392 SGTC_3331 9141060 1.957 µM 1.55495020201801 0.115268660355449 no 510 0.0599789648885162 70 4906567 YPR165W RHO1 SGTC_156 3474-0145 5.642 µM 1.55363722416653 0.115462508994879 no 511 0.0601354874403453 78 2265471 SGTC_1899 st063254 59.6 µM 1.54998074166271 0.116003574231676 no 512 0.0605730692103668 92 3093813 SGTC_1727 st034309 9.9045 µM 1.54904947295024 0.11614166514731 no 513 0.0606849138594817 111 870305 SGTC_772 k072-0172 35.3 µM 1.54268592287732 0.117088391526358 no 514 0.0614534995267076 71 5861980 SGTC_784 4579-0127 173 µM 1.54069029021058 0.117386411550178 no 515 0.0616960905494749 99 1948547 SGTC_612 0302-0167 22.4 µM 1.53914969845597 0.11761684464883 no 516 0.0618838772384962 100 235821 SGTC_1048 3161-0300 24.5 µM 1.53756038081418 0.117854901254124 no 517 0.0620780704392401 66 2165101 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 1.53507559443123 0.118227768832712 no 518 0.0623826301947868 91 688664 SGTC_3180 9109287 49.47 µM 1.52527909470316 0.119705958472618 no 519 0.0635947498755593 103 18891271 SGTC_2504 purpurogallin 52.29 µM 1.52404933421212 0.119892433233497 no 520 0.0637481938899668 86 5281571 An antioxidant. SGTC_360 0957-0399 1.01 µM 1.52196354672405 0.120209179715507 no 521 0.0640091074466938 102 6752301 YPR165W RHO1 SGTC_313 3474-0040 5.03 µM 1.5205793025642 0.120419715453546 no 522 0.064182722017983 120 1043375 YIL048W NEO1 SGTC_444 curcumin 90.4 µM 1.51890857050968 0.120674170108756 no 523 0.0643927557125464 100 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_2027 5150920 200 µM 1.51656271445268 0.121032085523566 no 524 0.0646885625591338 74 786715 SGTC_2768 sulfasalazine 50.2 µM 1.51391983990233 0.121436212005626 no 525 0.0650230857571683 86 5384001 An antioxidant and salicylic acid derivative. SGTC_1814 st052110 31.539 µM 1.51329508430851 0.121531882930017 no 526 0.0651023603937779 96 674163 SGTC_2233 sulbentine 40.3845 µM 1.51101795334448 0.121881036069982 no 527 0.0653919383838561 126 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_2816 7982706 58.44 µM 1.51044285326133 0.121969327672713 no 528 0.0654652304519905 108 2981853 SGTC_1242 0402-0103 60.1 µM 1.50700115139977 0.122498649995495 no 529 0.0659051810360974 88 432868 SGTC_1669 st015249 58.4 µM 1.50673069835651 0.122540312979684 no 530 0.0659398497444579 75 722793 SGTC_605 1315-0399 119 µM 1.50508035040692 0.122794762647491 no 531 0.066151710089899 111 24020461 SGTC_1980 st071811 45.7 µM 1.50021568721532 0.123546948597003 no 532 0.0667792704980065 106 4974850 SGTC_1801 st050089 28.441 µM 1.50020309523589 0.12354889977728 no 533 0.0667809008687128 108 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_984 1492-0255 2.91 µM 1.49213177126959 0.124804028559262 no 534 0.0678323021873397 86 1585198 SGTC_2421 5690543 90.72 µM 1.49099503764625 0.124981509222631 no 535 0.0679813988776913 103 3397993 SGTC_2698 st077697 67.5 µM 1.48638451373029 0.125703167626695 no 536 0.0685887218305496 97 3154499 SGTC_509 pifithrin 175 µM 1.48455828955101 0.125989818062592 no 537 0.0688304357355938 88 4817 A p53 inhibitor. SGTC_2970 9090938 41.86 µM 1.48195523765072 0.126399189392312 no 538 0.0691761028917576 106 17217104 SGTC_600 1495-0418 41.6 µM 1.48190656902763 0.126406852123385 no 539 0.069182578460229 119 5377768 SGTC_2177 5811945 192 µM 1.48066680833734 0.126602157927725 no 540 0.0693476914563545 95 5343475 SGTC_381 3461-2219 42.7 µM 1.47766685389198 0.127075625308775 no 541 0.0697484852391946 98 2883159 SGTC_2737 bleomycin 30.5 nM 1.47691193693418 0.127194963772944 no 542 0.0698496223642159 102 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_2253 7938677 135.83 µM 1.47658996441023 0.127245885410071 no 543 0.0698927917248604 82 2301972 SGTC_71 0417-1750 47.813 µM 1.47402835033545 0.127651523346665 no 544 0.0702369790538994 92 6811472 SGTC_656 4090-1979 187 µM 1.46209531747374 0.129552991772656 no 545 0.0718575458658282 102 22330961 SGTC_3066 9117245 49.47 µM 1.46209035146438 0.129553787144124 no 546 0.0718582261942054 84 17176980 SGTC_2797 7859098 81.82 µM 1.45998383127874 0.129891479051801 no 547 0.0721472588418392 108 972681 SGTC_2979 9012552 45.46 µM 1.45658341664509 0.130437877422608 no 548 0.07261570402969 103 17100905 SGTC_371 0195-0006 7.36 µM 1.45657598658984 0.130439073065026 no 549 0.0726167301474829 103 3928593 SGTC_1839 st053978 48 µM 1.45482346330334 0.130721300398031 no 550 0.0728590703832818 81 3788398 SGTC_973 1325-0077 65.9 µM 1.44775127550407 0.131864496827761 no 551 0.0738433120047367 93 2835149 SGTC_3341 9147222 25.867 µM 1.44578841449291 0.132183006057564 no 552 0.0741182783027706 104 1939759 SGTC_1309 pyrazolanthrone 13.4 µM 1.44002661090793 0.133121023498605 no 553 0.0749299352283408 111 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_2149 5554786 194.827 µM 1.43304440177041 0.134263848541959 no 554 0.0759225743124759 90 745063 YPR165W RHO1 SGTC_2435 5706476 10.6 µM 1.43227238482103 0.134390622203549 no 555 0.0760329415095714 91 5725375 SGTC_582 0987-0078 156 µM 1.43209427815749 0.134419880938051 no 556 0.0760584208902658 105 1625765 SGTC_1437 4092-1038 11.6 µM 1.43144957435338 0.134525827172598 no 557 0.0761507045464869 117 3977136 SGTC_2203 7227154 166.4 µM 1.43084029523892 0.134626004626142 no 558 0.0762379957808466 84 896304 SGTC_1039 k821-0043 94 µM 1.42241198331211 0.136017038406259 no 559 0.0774533431863758 88 15992768 SGTC_534 k292-0788 63.4 µM 1.42147479499465 0.136172320450795 no 560 0.0775893879865321 132 4146317 SGTC_2322 7413319 38.22 µM 1.40598117231327 0.138757034985862 no 561 0.0798648578136781 133 1840400 SGTC_484 loperamide 105 µM 1.40515097019955 0.138896469953444 no 562 0.0799881950899383 59 3955 An opioid-receptor agonist. SGTC_1266 0828-0227 32.9 µM 1.40462658107548 0.138984591847907 no 563 0.0800661740660953 112 3913820 SGTC_2803 7707263 71.43 µM 1.40393073495323 0.139101585289449 no 564 0.0801697381675681 91 2199229 SGTC_3305 9127027 53.8275 µM 1.40234709108104 0.139368095047302 no 565 0.0804058123014593 107 41905295 SGTC_2431 5490079 200 µM 1.40069229178274 0.139646950395971 no 566 0.0806530543634094 140 5722345 SGTC_155 k072-0202 43.6 µM 1.39036096004144 0.14139649067848 no 567 0.0822096475732847 118 5857737 SGTC_3356 9151811 4.48 µM 1.38979617585656 0.141492559387731 no 568 0.0822953898445675 113 1859254 YPR165W RHO1 SGTC_2235 salicylic acid 500 µM 1.38915499690078 0.141601676297794 no 569 0.0823928115350064 97 338 A COX inhibitor and kinase inhibitor. SGTC_1694 st024011 44.9 µM 1.38611967799532 0.142119005578702 no 570 0.0828551812897192 113 2787533 SGTC_2506 ethyl hematommate 54.16 µM 1.38611290821584 0.142120160824436 no 571 0.0828562147067231 85 3940691 An allergen. SGTC_2639 lactacystin 53 µM 1.38384258234209 0.142507944692837 no 572 0.0832033305766876 104 3870 A proteasome inhibitor. SGTC_837 0091-0265 12.5 µM 1.38265177007173 0.142711627682703 no 573 0.0833858334795353 125 759367 SGTC_2264 7948757 110.76 µM 1.37840766966888 0.14343916180753 no 574 0.0840387283685207 85 2971411 SGTC_1009 4106-0057 9.87 µM 1.37706170899501 0.143670411770636 no 575 0.0842465849625715 133 2928005 SGTC_1263 0774-1208 64.8 µM 1.37640834986635 0.143782756283507 no 576 0.0843476221617277 133 906585 SGTC_3335 9143315 29.6265 µM 1.37610316705242 0.143835252496726 no 577 0.0843948475908875 96 4899691 SGTC_742 0kpi-0133 140 µM 1.37576381055022 0.143893642300254 no 578 0.0844473845114889 114 2728852 SGTC_2720 fluspirilene 36.88 µM 1.36842768002485 0.145159808886146 no 579 0.0855891224468132 107 3396 An atypical antipsychotic. SGTC_23 0213-0011 39.996 µM 1.36301023214337 0.146099622438929 no 580 0.0864396429376676 122 627608 SGTC_2900 5328528 85.29 µM 1.36124364058084 0.146406970814622 no 581 0.0867183535413872 108 795359 SGTC_447 ml7 120 µM 1.36006879745281 0.146611608037782 no 582 0.0869040769937755 91 4216 Selective myosin light chain kinase inhibitor. SGTC_1881 5652484 16 µM 1.3587806584737 0.146836199938244 no 583 0.0871080520134581 96 2255129 SGTC_3141 9094609 49.47 µM 1.35447580915123 0.147588440411306 no 584 0.0877923130307221 149 25236309 YDL196W YDL196W SGTC_3130 9127414 49.47 µM 1.35328206553416 0.147797494616761 no 585 0.0879827682262038 113 1494646 SGTC_931 2812-0076 566 µM 1.3511617653981 0.148169300553858 no 586 0.0883218097194738 123 3450959 SGTC_557 1315-0110 16.2 µM 1.34462248482687 0.149319936938822 no 587 0.0893735892143373 110 6833801 SGTC_2246 7293507 91.5585 µM 1.34378286761279 0.149468105006711 no 588 0.0895093055803011 129 887656 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 1.33811987128717 0.150470021917604 no 589 0.0904286820251986 136 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_599 1935-0052 86.5 µM 1.33586234595654 0.150870675550378 no 590 0.0907971351608817 96 9557311 SGTC_159 3970-0959 50 µM 1.33566226719214 0.150906218695568 no 591 0.0908298438939751 144 6615653 SGTC_2383 9036125 200 µM 1.33437190860926 0.151135579307892 no 592 0.0910410008318753 123 79580 SGTC_2023 5144124 124 µM 1.3320725178384 0.151544869517105 no 593 0.0914181800249635 118 2830192 SGTC_1088 bifonazole 369 nM 1.32882443001086 0.152124281739166 no 594 0.0919529501468529 104 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_1777 st045864 34.765 µM 1.3272568995852 0.152404432257684 no 595 0.0922118580012668 150 4691462 SGTC_1722 st034304 3.6505 µM 1.32722017267715 0.152411000228149 no 596 0.0922179306208652 126 4036148 YLR033W RSC58 SGTC_1769 st044406 64.4 µM 1.32231291343087 0.153290267973161 no 597 0.093031987218769 161 670903 SGTC_2911 7942208 15.64 µM 1.3217928684935 0.15338364460464 no 598 0.093118566866893 95 1243384 SGTC_387 norethindrone acetate 66.7 µM 1.3171208143489 0.154224224546125 no 599 0.0938990655682782 117 541197 SGTC_1162 k048-0130 20.1 µM 1.31314434840009 0.154942052222381 no 600 0.0945671562032509 120 6797406 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 1.31175403600917 0.155193549830468 no 601 0.0948015690414025 127 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_1414 3917-0015 5.4 µM 1.30937371172188 0.155624758834682 no 602 0.0952038958902111 110 6618702 SGTC_876 0720-0963 56.8 µM 1.30900323867763 0.155691943091042 no 603 0.0952666268389468 116 765861 SGTC_2026 5148700 152 µM 1.3086136996604 0.155762605535179 no 604 0.0953326189826232 126 79838 SGTC_291 SEC14.278 35.5 µM 1.30561479600794 0.156307315160972 no 605 0.0958417930593273 118 1068044 SGTC_1018 4259-0013 28.1 µM 1.29994017826335 0.157341460865063 no 606 0.0968107365510212 116 6801262 SGTC_606 k015-0008 38.6 µM 1.29788503641188 0.157717098042701 no 607 0.0971634213576543 128 1970475 SGTC_1077 5-fluorocytosine 377 nM 1.29723354810131 0.157836299424056 no 608 0.0972754204620154 152 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2307 7538926 6.34 µM 1.2966787169797 0.15793786229041 no 609 0.0973708776308241 150 96582 SGTC_2664 lyso-paf C-16 73.48 µM 1.29631587876621 0.158004303700223 no 610 0.0974333401004819 135 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2981 9013952 38.96 µM 1.29503378119195 0.158239222980081 no 611 0.0976542881549673 112 2996344 SGTC_611 3453-1652 23.7 µM 1.29477722652496 0.158286259106856 no 612 0.0976985451352381 149 1560575 SGTC_1118 chelidonine 707.474 nM 1.29419138861711 0.158393699633854 no 613 0.0977996602692936 108 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_1933 st074711 15.9 µM 1.29312946342806 0.158588574754654 no 614 0.0979831431931898 135 17250958 SGTC_1054 3429-0080 167 µM 1.2926419505084 0.15867809145081 no 615 0.0980674617138047 131 1162877 SGTC_2217 6934799 96.0675 µM 1.29238981665777 0.158724401043093 no 616 0.0981110907507527 116 675606 SGTC_2863 9028737 58.44 µM 1.29095015790239 0.158988993843723 no 617 0.0983604805760163 107 6460917 SGTC_1343 1487-0095 224 µM 1.28983338973363 0.159194441988208 no 618 0.0985542560747239 137 4560101 YGL055W OLE1 SGTC_1351 1496-0003 46.5 µM 1.28685604249384 0.159743024099069 no 619 0.0990722345313112 122 3891978 SGTC_1419 3993-2473 62.6 µM 1.2817687812947 0.160683220783165 no 620 0.099961884303927 128 704026 SGTC_1011 4112-3381 17.4 µM 1.28114865301173 0.160798075736 no 621 0.100070728734452 128 2877139 SGTC_2891 9063876 19.48 µM 1.28007847862738 0.160996410487617 no 622 0.100258768382612 97 6472478 SGTC_660 4031-1742 102 µM 1.27763283277326 0.161450259608186 no 623 0.10068945910504 138 6738706 SGTC_74 000s-0487 160.283 µM 1.27399290522932 0.162127280084179 no 624 0.101332965284499 107 677548 SGTC_987 1497-1013 404 µM 1.27257024479349 0.162392394341938 no 625 0.101585291429928 127 1676435 SGTC_2201 6605497 169.863 µM 1.27128262826197 0.1626325861466 no 626 0.101814060076949 124 670741 SGTC_3189 9110682 49.47 µM 1.26980600119879 0.162908320298155 no 627 0.10207687126265 130 17122418 SGTC_1848 st056003 16.4 µM 1.26280116796427 0.164220488209737 no 628 0.103330322440753 128 146492 SGTC_695 3505-6186 243 µM 1.2626551064571 0.164247921669986 no 629 0.103356577221812 141 1819379 SGTC_175 3793-3120 23.7 µM 1.26203249841487 0.164364894044492 no 630 0.103468546296432 123 5322297 SGTC_2587 piperic acid 92.2 µM 1.26075215599607 0.164605607828487 no 631 0.10369907814889 106 5370536 SGTC_1717 st033143 58.0435 µM 1.26000666418877 0.164745870941974 no 632 0.103833479098866 115 674616 SGTC_140 0062-0056 502.533 µM 1.25875812187513 0.16498095559271 no 633 0.10405885541013 115 3758964 SGTC_254 nsc-64875 3.808 µM 1.25848249746854 0.165032881419758 no 634 0.10410865655733 111 56993 SGTC_429 1112-0049 25.5 µM 1.25807062752242 0.16511049472875 no 635 0.104183107405522 128 2836170 SGTC_3350 9150499 3.57 µM 1.2570694534332 0.165299255787734 no 636 0.104364243557111 133 4910996 YPR165W RHO1 SGTC_1019 4262-0212 3.4 µM 1.25702300753691 0.165308016071033 no 637 0.104372652257822 148 4677213 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 1.25625399948195 0.165453104377634 no 638 0.104511947087112 115 4174840 SGTC_2622 2-methoxyxanthone 59.94 µM 1.25162059093214 0.166329029705086 no 639 0.105354073951102 128 71034 A hepatoprotective. SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 1.24793996794356 0.167026965409779 no 640 0.1060265212334 140 688662 SGTC_2658 polymyxin b sulfate 77.05 µM 1.24574655037562 0.167443787540963 no 641 0.106428728949251 143 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_666 0272-0154 136 µM 1.24487004329828 0.167610540238926 no 642 0.106589762041569 153 6870312 SGTC_199 4063-0024 41.6 µM 1.24374299467324 0.16782511481211 no 643 0.106797083348634 91 306215 SGTC_3142 9086498 49.47 µM 1.2434898372696 0.167873336817426 no 644 0.106843691806191 173 25236367 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 1.24014270387968 0.168511744970921 no 645 0.107461308142053 135 4330530 SGTC_54 0159-0055 9 µM 1.23992931490595 0.168552498109976 no 646 0.107500769956581 131 3319099 SGTC_3166 9102297 49.47 µM 1.23930805643922 0.16867118245378 no 647 0.107615718138907 128 25237072 SGTC_2802 7925815 54.55 µM 1.23636893856008 0.169233395328104 no 648 0.108160728256906 138 1262923 SGTC_1311 1190-0148 100 µM 1.23300875059838 0.16987762532265 no 649 0.108786249714758 149 1961333 SGTC_2951 9072950 58.06 µM 1.23290080774335 0.169898346634663 no 650 0.108806387032349 135 16488155 SGTC_1411 3909-8223 150 µM 1.23029853916057 0.17039838300314 no 651 0.109292665583494 150 X1411 SGTC_497 capsazepine 133 µM 1.22921044162717 0.170607744497067 no 652 0.109496457510325 116 2733484 A calcium channel blocker. SGTC_1760 st045453 10.4495 µM 1.22708055794332 0.171018033139739 no 653 0.10989615721516 145 3323419 YIL048W NEO1 SGTC_3037 9091026 49.47 µM 1.22657176494825 0.171116137438653 no 654 0.109991793423954 134 25236398 YIL048W NEO1 SGTC_2933 9026794 32.47 µM 1.22532834299499 0.171356042636457 no 655 0.11022576677613 144 17586027 SGTC_1331 1472-0049 76.2 µM 1.21505364912081 0.173346659371895 no 656 0.112172815109074 158 24051409 SGTC_3074 9116018 49.47 µM 1.21347006226092 0.1736547673463 no 657 0.112475076841849 142 17027303 SGTC_3050 9093513 49.47 µM 1.21098785374401 0.174138414793786 no 658 0.112950029930252 159 25236664 SGTC_1151 3909-8316 15.3 µM 1.20905589053414 0.174515441282538 no 659 0.113320686907593 147 800431 SGTC_1149 3909-7961 23.3 µM 1.20793943108196 0.174733556769133 no 660 0.113535280494613 130 735261 SGTC_1939 st074455 53.6 µM 1.19984014505041 0.176321039974795 no 661 0.115100714801089 143 1644229 SGTC_1891 st059073 26.2 µM 1.19477234231841 0.177318970414288 no 662 0.11608799454386 157 688754 SGTC_2002 4023503 131 µM 1.19421875632653 0.177428195899625 no 663 0.116196204000679 166 4736863 YCR052W RSC6 SGTC_1570 verbenone 133 µM 1.19115901415608 0.178032665350015 no 664 0.116795583034998 145 29025 A natural terpanoid with antifungal properties. SGTC_957 1187-1561 14.1 µM 1.19013370807616 0.178235510496577 no 665 0.116996921735699 144 1538454 SGTC_1293 1000-1278 195 µM 1.18948612467689 0.178363702528 no 666 0.117124213937181 151 678847 SGTC_2370 9071495 200 µM 1.18854605330157 0.178549897208379 no 667 0.117309173580242 152 21791103 SGTC_2173 5763948 167 µM 1.18745307378597 0.178766531394989 no 668 0.117524477961204 150 2867177 SGTC_2049 5262831 67.185 µM 1.18376737181201 0.179498275695156 no 669 0.118252580710703 134 763417 SGTC_190 3970-0790 3.722 µM 1.1832757984347 0.179596012780217 no 670 0.11834993054412 138 2832352 SGTC_2790 5423970 71.43 µM 1.18111826101881 0.180025380615548 no 671 0.118777873283618 159 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_1609 st001574 46.4 µM 1.17799163334198 0.180648748176462 no 672 0.119399970870579 170 3960012 SGTC_797 k781-0471 270 µM 1.17599064533334 0.181048402133089 no 673 0.119799307123812 158 23738129 SGTC_2857 9024691 58.44 µM 1.17258998385125 0.181728880099765 no 674 0.120480133979113 155 16478292 SGTC_3231 9132313 49.47 µM 1.17237028892592 0.181772896374133 no 675 0.120524211349754 150 4905967 SGTC_1750 st081859 2.357 µM 1.1695602054518 0.182336489766161 no 676 0.121088999808553 182 5291695 SGTC_670 4204-0025 119 µM 1.16871826483657 0.182505562641133 no 677 0.121258580299269 130 719039 SGTC_125 0133-0007 11.75 µM 1.1685573620884 0.182537885195048 no 678 0.121291007721549 146 26541 SGTC_1514 1189-1591 158 µM 1.16622101250367 0.183007619846585 no 679 0.121762549533042 159 767698 YMR146C TIF34 SGTC_1112 tnp00069 1.16933 µM 1.16524890528431 0.183203288813338 no 680 0.121959127393664 146 145826 SGTC_834 0312-0008 75.7 µM 1.16232896102723 0.183791809073659 no 681 0.122550933499476 141 6385573 YIL048W NEO1 SGTC_88 0180-0332 8.668 µM 1.16162398825441 0.183934073955795 no 682 0.122694116851676 157 3101745 SGTC_3090 9117696 49.47 µM 1.16080493757792 0.184099446074146 no 683 0.122860617286353 135 7923821 SGTC_620 0109-0052 432 µM 1.15833239306729 0.184599231483636 no 684 0.123364208510301 161 493037 SGTC_1682 st012968 530 nM 1.15750862915485 0.184765929409993 no 685 0.123532307914527 128 24207270 SGTC_2711 st079103 59.1 µM 1.15328054397719 0.185623002105687 no 686 0.124397626619231 137 54693780 SGTC_782 0083-0095 30.5 µM 1.15319351803727 0.185640668954355 no 687 0.124415481731632 148 3591729 An indicator and reagent. SGTC_414 piperonyl butoxide 100 µM 1.15050197448626 0.186187585337333 no 688 0.124968590720662 154 5794 A potent inhibitor of cytochrome P450. SGTC_2592 piperlongumine 83.33 µM 1.15013734390296 0.186261754285749 no 689 0.125043653779887 162 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_2583 asiatic acid 100 µM 1.14814280382625 0.186667784515041 no 690 0.125454808186856 183 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_915 methyl methanesulfonate (MMS) 110 mM 1.14299098919629 0.187719076878333 no 691 0.126521166142794 174 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_1700 st030840 7.9285 µM 1.14118130033716 0.188089232887025 no 692 0.126897242174807 175 5499307 SGTC_563 tetrahydrosecaminediol 614 µM 1.1382592235049 0.188687868319611 no 693 0.127506127726512 136 334274 A psychoactive constituent of the cannabis plant. SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 1.13785600082569 0.188770567224973 no 694 0.127590308189869 169 688788 SGTC_3346 9158254 43.5805 µM 1.1375930965809 0.188824499567161 no 695 0.127645215295618 180 17639500 SGTC_1202 1988-0068 29.6 µM 1.13361695192087 0.189641325739749 no 696 0.128477629553017 130 2850480 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 1.13314132962438 0.189739178983101 no 697 0.128577453826557 157 756377 SGTC_756 0508-1999 28.3 µM 1.13218173814155 0.189936697241188 no 698 0.128779018050058 159 6753853 SGTC_2277 7947813 106.88 µM 1.13114171310004 0.19015091428588 no 699 0.128997724937328 144 1246798 SGTC_2718 lomofungin 53.02 µM 1.1268397881959 0.191038570544382 no 700 0.129905112331309 146 5351222 A RNA synthesis inhibitor. SGTC_2739 tacrine 100.86 µM 1.12575428106348 0.191262954237382 no 701 0.130134770397684 142 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_1105 epirubicin 18.1 µM 1.11979112070647 0.192498470038851 no 702 0.131401391981608 165 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_858 0438-0351 2.77 µM 1.11856245564471 0.19275364383839 no 703 0.131663423994898 159 2799119 SGTC_923 1900-2434 73.3 µM 1.11678641003512 0.193122864786102 no 704 0.13204283043619 176 5910570 SGTC_1150 3909-7983 10.9 µM 1.11218094139237 0.194082302169329 no 705 0.133030180312044 178 23965914 SGTC_2897 9048598 12.99 µM 1.11119781552496 0.194287488005395 no 706 0.133241605665051 132 6467404 SGTC_3234 9132280 49.47 µM 1.10757710468043 0.195044296220801 no 707 0.134022247913204 145 17612295 SGTC_1968 st069590 43.6 µM 1.0998784316477 0.196659433818466 no 708 0.135692546647387 182 6384066 SGTC_3091 9116372 49.47 µM 1.09867129898141 0.196913416104198 no 709 0.135955732907227 154 17169793 SGTC_2726 cimetidine 79.27 µM 1.09776151507035 0.197104966993104 no 710 0.136154320235938 176 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_900 1112-0045 141 µM 1.09714587386487 0.197234651410882 no 711 0.136288814761956 159 56211 YIL048W NEO1 SGTC_741 4582-0002 126 µM 1.09581652071064 0.19751485479938 no 712 0.136579538576735 182 2912688 SGTC_2298 7976326 193.81 µM 1.09387553056512 0.197924412090452 no 713 0.137004785966952 115 2235818 SGTC_2188 6126565 140.678 µM 1.0937994200988 0.197940482171963 no 714 0.137021479260334 156 874518 SGTC_961 1252-1571 372 µM 1.09323528717232 0.198059618637866 no 715 0.137145253749857 168 6813498 SGTC_2196 6573537 42.6665 µM 1.08812430587353 0.199140953718353 no 716 0.138270117463215 174 2903087 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 1.0879645443712 0.199174811829915 no 717 0.138305380074217 149 6312947 SGTC_1533 dihydroergotamine mesylate 29.4 µM 1.08641163034953 0.199504100130243 no 718 0.138648459154486 202 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_1636 st007707 68.9 µM 1.08478801595104 0.199848730286271 no 719 0.139007777248372 178 403051 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 1.08429579691165 0.199953279921109 no 720 0.139116834142945 152 2374 Ca(2+)-ATPase inhibitor. SGTC_3117 9124945 49.47 µM 1.07739784094889 0.201421895387788 no 721 0.14065128413852 133 17592065 SGTC_499 genistein 192 µM 1.07472875620564 0.20199188948308 no 722 0.141248092644978 155 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_2851 9015922 71.43 µM 1.07336066085945 0.202284425782526 no 723 0.141554663914111 181 2996893 SGTC_712 r015-0009 80.6 µM 1.07065669235882 0.202863353259036 no 724 0.142161911139546 155 6813872 YLR060W FRS1 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 1.07052068945689 0.202892497992522 no 725 0.142192500664164 179 91467 include heat shock SGTC_419 nsc-638432 893 µM 1.06935765740355 0.203141832001816 no 726 0.142454269621002 164 368090 SGTC_694 1315-0438 43.2 µM 1.06794859166947 0.203444156314798 no 727 0.142771850934824 158 6793154 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 1.06715612030678 0.203614304119414 no 728 0.142950671669855 171 4213774 SGTC_3323 9138564 53.9225 µM 1.06639806076516 0.203777142908849 no 729 0.143121868975095 162 43912313 YNL103W MET4 SGTC_485 niflumic acid 177 µM 1.06367460803877 0.204362807985182 no 730 0.143738065564033 159 4488 A COX2 inhibitor. SGTC_544 k015-0020 52.4 µM 1.05488404214478 0.206260000819333 no 731 0.145739180722626 180 3008304 SGTC_753 1322-0200 289 µM 1.05354904750471 0.206549031662691 no 732 0.146044713715554 157 5403907 SGTC_2035 5154463 94.595 µM 1.05131248833322 0.207033791548939 no 733 0.146557546639751 211 2769623 SGTC_2642 cholecalciferol 100 µM 1.05021153184412 0.207272663851162 no 734 0.146810434382986 146 9821465 A vitamin D precursor, similar to steriods. SGTC_3282 9108498 15.4605 µM 1.04751850211382 0.207857651533274 no 735 0.147430251658521 171 16459645 SGTC_1034 k072-0165 12.7 µM 1.04083578270183 0.20931349611095 no 736 0.148975884889746 196 5835461 SGTC_9 0092-0002 10.449 µM 1.0404964258928 0.209387585475149 no 737 0.14905466185104 194 759368 SGTC_2334 9017922 200 µM 1.03936417655091 0.209634893052111 no 738 0.149317699048304 158 3163164 SGTC_1564 D-Arginine 115 µM 1.03911082092405 0.209690254873821 no 739 0.149376599474064 194 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_1872 amphotericin b 148 nM 1.03305820543321 0.211015391870341 no 740 0.150788330332705 168 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_575 k072-0246 11.9 µM 1.02809843980557 0.212104914813153 no 741 0.151951762240019 176 6796779 SGTC_917 harmaline 728.087 nM 1.0270200322162 0.212342245656096 no 742 0.1522055157228 177 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_2135 5326629 150.42 µM 1.02453595916707 0.212889518773742 no 743 0.152791097639654 163 5020077 SGTC_1900 st060200 72.8 µM 1.0245098323399 0.212895279219684 no 744 0.152797264565875 175 688945 SGTC_2998 9066762 71.4286 µM 1.02443705038247 0.212911326673916 no 745 0.152814444750065 163 4945196 SGTC_1237 0330-0133 46.1 µM 1.0215485908818 0.213548763324677 no 746 0.153497300011817 207 X1237 YHR072W ERG7 SGTC_1979 st071809 45.3 µM 1.01986602122047 0.213920591448122 no 747 0.153896003193121 173 4976333 SGTC_91 0417-1751 58.384 µM 1.01919606047708 0.214068749758308 no 748 0.154054948285975 187 6795624 SGTC_3293 9120939 62.045 µM 1.01871636263187 0.214174869103239 no 749 0.15416882108224 180 934087 SGTC_3286 9117135 37.221 µM 1.01716064886934 0.214519236538241 no 750 0.154538506270259 200 3438150 SGTC_2309 7664088 163.95 µM 1.01680110365409 0.214598869998525 no 751 0.154624028501573 180 704922 SGTC_1187 1391-0724 117 µM 1.01207782656879 0.21564659406522 no 752 0.155750421663941 170 6997986 SGTC_3133 9127736 49.47 µM 1.01202803490003 0.215657654698458 no 753 0.155762324581886 167 27243420 SGTC_1342 1486-1464 234 µM 1.01086576257176 0.215915933253361 no 754 0.1560403413212 186 3253938 SGTC_1073 triclabendazole 3.09 µM 1.00978222453406 0.21615687693424 no 755 0.156299819110486 175 50248 An antihelmetic and likely tubulin inhibitor. SGTC_3242 9133940 49.47 µM 1.00920912051592 0.216284379592545 no 756 0.15643717673786 156 17248444 SGTC_3129 9127257 49.47 µM 1.00651899327047 0.216883453506589 no 757 0.157082989918297 164 837894 SGTC_806 3966-4455 5.86 µM 1.00576438788472 0.217051671357752 no 758 0.157264460918249 166 714982 SGTC_257 daunorubicin 18.5 µM 1.00548834808646 0.21711322542458 no 759 0.157330878667101 174 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1967 st070177 51.4 µM 1.00534632753058 0.217144898492713 no 760 0.157365057319901 183 5729214 SGTC_3094 9117742 49.47 µM 1.00076819324014 0.218167331605877 no 761 0.158469445052549 222 17149698 SGTC_2013 4024628 200 µM 1.00006901481242 0.218323722723233 no 762 0.158638554943551 195 5230760 SGTC_2702 st077768 96.8 µM 0.998870949186069 0.218591854227411 no 763 0.158928605401675 174 6484119 SGTC_2619 obliquin 87.91 µM 0.998870343189044 0.218591989899733 no 764 0.158928752200815 181 6708593 A bioactive alkalod. YER133W GLC7 SGTC_1421 4029-0249 71.4 µM 0.994544063792329 0.219561804415964 no 765 0.159979032150974 205 2894095 SGTC_2692 st077426 47.7 µM 0.994290670309591 0.219618683700138 no 766 0.160040688244483 189 25238571 SGTC_2585 alliin 100 µM 0.994147000535434 0.219650937040876 no 767 0.160075653097293 175 87310 A garlic compound which reacts with lipids. SGTC_3065 9113888 49.47 µM 0.992500372178434 0.220020793291485 no 768 0.160476748996403 170 16648368 SGTC_965 1291-5240 308 µM 0.992181899842345 0.220092367940119 no 769 0.160554400166319 190 2834598 SGTC_2341 7987486 176.74 µM 0.991442036066188 0.220258699202697 no 770 0.160734891372887 172 1258686 SGTC_219 mitoxanthrone 164.414 µM 0.989779679326797 0.220632681993287 no 771 0.161140909629644 189 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_2806 7952793 58.44 µM 0.988127283390544 0.221004784127815 no 772 0.161545157635852 180 2972490 SGTC_2022 5136654 200 µM 0.985740088131616 0.22154298907154 no 773 0.162130336080646 208 1713771 SGTC_644 1498-1197 63.3 µM 0.984904551809439 0.221731541702993 no 774 0.162335478660631 190 6741615 SGTC_688 0527-0193 473 µM 0.983390049324408 0.222073547912767 no 775 0.162707752898212 219 4007154 SGTC_2189 6047310 154.431 µM 0.983354371274419 0.222081608388531 no 776 0.162716529476967 171 711535 SGTC_1165 k072-0275 30.3 µM 0.980797273940052 0.222659749085028 no 777 0.163346361426389 187 6153523 YGL055W OLE1 SGTC_1468 k284-1086 134 µM 0.979252822782402 0.223009353171027 no 778 0.163727537271208 194 15996457 SGTC_1737 st035557 69.7 µM 0.977539225852639 0.223397610930474 no 779 0.164151134037306 185 5716916 SGTC_2629 bisabolol 100 µM 0.977449119147399 0.223418037470876 no 780 0.164173427837464 219 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_949 1165-0505 146 µM 0.97728399355317 0.22345547301038 no 781 0.164214287573759 188 6244267 SGTC_1215 3852-0577 11.2 µM 0.976106220819809 0.22372258874393 no 782 0.164505914465638 179 2884876 SGTC_982 1491-0518 27.5 µM 0.975867083464498 0.223776846625131 no 783 0.164565167950195 174 3091256 SGTC_3240 9133527 49.47 µM 0.975115561128322 0.223947408231344 no 784 0.164751470271318 185 17617455 SGTC_2156 5649887 115 µM 0.974181129287839 0.224159585015417 no 785 0.164983306324356 194 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_2960 9079389 5.97 µM 0.973693562806551 0.224270339617283 no 786 0.16510435722726 156 16457355 SGTC_1130 3454-2858 15.9 µM 0.971498584566129 0.224769330971463 no 787 0.165650028814868 219 715628 YIL048W NEO1 SGTC_2840 9008771 71.43 µM 0.971021747240076 0.224877815089467 no 788 0.165768724590042 137 2992978 SGTC_3306 9127676 59.7925 µM 0.970125555680158 0.225081785780852 no 789 0.165991956021621 173 41905287 SGTC_420 mitomycin C 81.9 mM 0.969225282484763 0.22528679094397 no 790 0.166216399637919 189 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2849 9019321 12.99 µM 0.969096633029541 0.225316094909019 no 791 0.166248488734109 189 16489627 SGTC_3095 9117207 49.47 µM 0.964000879236015 0.226478547962689 no 792 0.167522742531153 149 17015229 SGTC_236 1509-0011 5.31 µM 0.963320164702617 0.226634089844884 no 793 0.167693438445618 231 3107280 SGTC_944 3370-0224 231 µM 0.960635258808811 0.227248172914071 no 794 0.168367796928276 162 4580514 SGTC_1080 nisoldipine 24.4 µM 0.959341839031921 0.227544334080529 no 795 0.168693282272047 198 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_1276 0871-0068 94.2 µM 0.959103981109956 0.227598821317779 no 796 0.168753182523314 213 3414906 SGTC_2126 5251174 33.877 µM 0.957088043926584 0.22806091644173 no 797 0.169261408882846 182 790722 SGTC_1515 3460-0031 42.1 µM 0.957063567758673 0.228066530133361 no 798 0.169267585460396 193 2876596 SGTC_237 nikkomycin 200 µM 0.954686738284533 0.228612034030806 no 799 0.169868069172485 198 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_1302 1159-0335 255 µM 0.953341974520877 0.228920993789475 no 800 0.170208415394697 178 649284 SGTC_955 1216-0110 33 µM 0.952091648162948 0.22920846662544 no 801 0.170525252152629 181 3619719 SGTC_467 ro 31-8220 72.8 µM 0.951329228411488 0.22938386014276 no 802 0.170718637021852 196 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_3089 9117425 49.47 µM 0.950405349731121 0.229596497820989 no 803 0.170953163366946 177 9401657 SGTC_1442 4112-3290 3 µM 0.948238670726748 0.230095608308013 no 804 0.171503982316218 193 704353 SGTC_2586 curcumin 80 µM 0.947238513133897 0.230326206616809 no 805 0.171758627235829 194 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_929 2805-0021 398 µM 0.946883548268234 0.230408079077088 no 806 0.171849061026027 215 3098024 SGTC_1451 4152-0210 104 µM 0.943902598862006 0.231096275170326 no 807 0.172609711928336 192 659563 SGTC_2876 9059903 25.97 µM 0.942165945311103 0.231497735473482 no 808 0.1730538430898 184 6916095 SGTC_1463 k081-0032 34.1 µM 0.942152985309625 0.231500732883759 no 809 0.173057160210152 188 977755 SGTC_1641 st009299 47.1 µM 0.939486047320953 0.232118006801107 no 810 0.173740626287537 195 4046054 SGTC_2827 7993847 71.43 µM 0.938970503118476 0.232237437235558 no 811 0.173872944488568 173 2985692 SGTC_1705 st027868 56.3335 µM 0.938816732252339 0.23227306625409 no 812 0.17391242331412 187 292948 SGTC_1480 1070-0044 41.2 µM 0.938076608414193 0.232444596974811 no 813 0.174102520968128 193 3124987 SGTC_942 3253-1115 227 µM 0.937502967830117 0.232577592069447 no 814 0.174249948929919 212 46497897 SGTC_1821 st053465 65.6 µM 0.933756072917633 0.23344732679842 no 815 0.175214866662833 181 675086 SGTC_47 0149-0135 24.25 µM 0.9324065664434 0.233761017578012 no 816 0.175563226274251 212 5239155 SGTC_2903 5923464 63.88 µM 0.932029176716593 0.233848783045971 no 817 0.175660723585195 213 2876576 SGTC_1037 k284-1091 78.7 µM 0.931836437731412 0.233893613321091 no 818 0.175710530257307 186 3334711 SGTC_2647 atorvastatin 60.16 µM 0.930971765885748 0.234094790935794 no 819 0.175934084644593 180 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_884 0851-0618 334 µM 0.929107246538364 0.234528922538489 no 820 0.176416754688819 211 9642473 SGTC_2810 7959871 45.46 µM 0.927460953647521 0.234912612582566 no 821 0.176843627913873 210 2974535 SGTC_328 k915-0120 63.5 µM 0.927082371628476 0.235000895095084 no 822 0.176941884063672 169 6624543 SGTC_2097 5376186 200 µM 0.924719392885917 0.235552338229548 no 823 0.177555944585414 202 742755 SGTC_3330 9141424 71.43 µM 0.924377137578205 0.235632268742476 no 824 0.177644996872365 182 27261020 SGTC_2345 9052315 157.45 µM 0.923443705399413 0.235850339083695 no 825 0.177888012204304 196 6469265 SGTC_6 0844-0013 19.835 µM 0.918429096413382 0.237023764538198 no 826 0.179197131777709 235 1584900 SGTC_356 1634-0012 32.5 µM 0.916538549787386 0.237466986501595 no 827 0.179692248950243 227 735457 SGTC_1005 4092-0690 4.4 µM 0.916232462948526 0.237538788627283 no 828 0.179772491114601 210 1529343 SGTC_2909 7941780 10.49 µM 0.915461964755242 0.23771958552375 no 829 0.179974580623607 192 1243215 SGTC_1267 0828-0272 9.49 µM 0.914850578224348 0.237863100671537 no 830 0.180135039123728 202 745334 SGTC_37 0566-0070 1.56 µM 0.91223324880463 0.238478021925458 no 831 0.180822972349155 203 1626686 SGTC_1385 3091-4834 14.1 µM 0.91045455031502 0.238896409542645 no 832 0.181291420199281 175 4072814 SGTC_3318 9139014 38.6185 µM 0.908037357591617 0.239465627393248 no 833 0.181929242319709 234 16643984 SGTC_65 0798-0905 34.986 µM 0.905592007916157 0.240042228615585 no 834 0.182575920259773 197 3602145 SGTC_1174 0739-0097 51.1 µM 0.904569852553492 0.240283471885997 no 835 0.182846656345036 210 728447 SGTC_924 2046-0044 21.3 µM 0.904258196309686 0.240357053483609 no 836 0.182929253885201 195 3623589 SGTC_1806 st050005 60.3 µM 0.903459886027823 0.240545589388688 no 837 0.183140934419627 201 5194765 SGTC_2034 5197015 53.07 µM 0.903448139309247 0.24054836419701 no 838 0.18314405032831 218 780676 SGTC_1007 4101-0031 70 µM 0.901704913073382 0.240960342011501 no 839 0.183606821214067 231 1146276 SGTC_788 1182-0090 188 µM 0.90043483263881 0.241260742448031 no 840 0.18394444543615 200 5715185 SGTC_2226 7298446 200 µM 0.898191623295076 0.241791804908703 no 841 0.18454169923568 190 3283010 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.895718626036551 0.24237800228748 no 842 0.18520152996283 212 688664 SGTC_790 1575-0012 79.1 µM 0.895706458052254 0.242380888479632 no 843 0.185204780171668 223 378741 YLR208W SEC13 SGTC_1120 ficusin 1.78878 µM 0.893583736238054 0.242884673587101 no 844 0.185772325672162 208 6199 A DNA cross-linker. SGTC_1761 st044296 37 µM 0.893242588550667 0.242965690905519 no 845 0.185863637781464 222 1826700 SGTC_817 1391-0715 46 µM 0.890567055600148 0.243601595382603 no 846 0.186580739841274 229 1353946 SGTC_1369 1866-0067 208 µM 0.887896073220536 0.244237313737849 no 847 0.187298328591142 206 3531355 SGTC_2306 7482397 179.52 µM 0.887666559140979 0.24429198189616 no 848 0.187360069578436 222 891448 SGTC_2397 5161689 200 µM 0.886649877848255 0.244534225399293 no 849 0.187633715652908 217 2259942 SGTC_1058 3448-5425 97.3 µM 0.884884181580081 0.244955243175806 no 850 0.1881095501988 225 7279705 SGTC_1513 0337-0559 19 µM 0.883961639158759 0.245175371912803 no 851 0.188358460570066 205 775073 SGTC_3324 9138759 60.749 µM 0.880927362336302 0.245900133313627 no 852 0.189178568234146 205 45595710 SGTC_869 0564-0080 44.1 µM 0.880462960537104 0.246011160783427 no 853 0.18930428099203 183 6843321 SGTC_2380 9035439 200 µM 0.87791433669852 0.246620954896877 no 854 0.189995104162185 198 6462575 SGTC_2159 5658611 73.75 µM 0.87732177938645 0.246762848479029 no 855 0.190155942915851 195 793844 SGTC_1090 efavirenz 20.7 µM 0.876688461693369 0.246914550838705 no 856 0.190327937786276 208 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_1416 3966-0321 25.3 µM 0.876016881574736 0.247075472935655 no 857 0.190510428225105 216 582530 YLR208W SEC13 SGTC_2101 5377231 179.231 µM 0.870319885856872 0.248442824356189 no 858 0.192062807237872 214 2844213 SGTC_2671 danthron 100 µM 0.869722791964897 0.248586367603647 no 859 0.19222595678906 218 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_1681 tripelennamine 100 µM 0.86739999203981 0.249145195988204 no 860 0.192861443110935 190 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_2301 7769476 200 µM 0.867244940225585 0.249182522742333 no 861 0.192903908810575 205 977820 SGTC_2198 6589944 200 µM 0.866468959561821 0.249369374907557 no 862 0.193116520740088 195 5290268 SGTC_2138 5575593 77.673 µM 0.866381299326585 0.249390487723838 no 863 0.193140547869708 215 762213 SGTC_2112 5488546 200 µM 0.863853637091581 0.249999679274407 no 864 0.193834149252905 233 600757 SGTC_3051 9093778 49.47 µM 0.863755167722776 0.250023427333764 no 865 0.193861200360944 246 17217378 SGTC_2136 5328288 199.296 µM 0.862964822698802 0.250214079812702 no 866 0.194078404101327 199 262395 SGTC_396 dithiazanine 1.25 µM 0.86024800958363 0.250870035788673 no 867 0.194826172575035 187 10578 An antihelmenthic. SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.858765857335524 0.251228274714931 no 868 0.195234853979639 199 803109 SGTC_2834 9001755 58.44 µM 0.858698613488315 0.251244534089152 no 869 0.195253407813849 216 2989575 SGTC_2531 methyl deoxycholate 70.07 µM 0.858316986012774 0.251336821084752 no 870 0.19535872626011 218 16667744 Haematoxylin. SGTC_305 1682-2595 20.8 µM 0.858166733775279 0.251373160721193 no 871 0.195400201117044 229 226033 SGTC_1520 flindersine 88 µM 0.857538486872566 0.251525137050923 no 872 0.195573677099182 230 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_2867 9039098 71.43 µM 0.857531621640463 0.251526798055881 no 873 0.195575573292065 216 6463460 SGTC_1983 st071813 46.9 µM 0.85686556088021 0.251687975328525 no 874 0.195759593880948 209 11838595 SGTC_38 0929-0051 58.268 µM 0.856307375273495 0.25182309033992 no 875 0.195913891420025 218 1379719 SGTC_1838 st055369 84.5 µM 0.856066437576523 0.251881423808944 no 876 0.195980515884067 207 676036 SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.854392185947976 0.252286974077505 no 877 0.196443862035978 241 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.853086958329676 0.252603375125912 no 878 0.196805541566064 228 688803 SGTC_3264 9137442 49.47 µM 0.853078207708084 0.25260549707476 no 879 0.196807967729695 229 17015726 SGTC_3253 9135987 49.47 µM 0.852519755055577 0.252740936354542 no 880 0.196962839618399 215 4182430 SGTC_1752 st044819 83.042 µM 0.851540479765162 0.252978528344329 no 881 0.197234593441372 221 441209 YML126C ERG13 SGTC_962 1254-0300 21.5 µM 0.851058207268473 0.253095580583699 no 882 0.197368509808357 201 7340576 SGTC_2536 dehydroabietamide 32.04 µM 0.849244723342816 0.253535985680943 no 883 0.197872566006846 203 3983547 SGTC_3210 9128157 49.47 µM 0.848828831604189 0.253637041834999 no 884 0.19798827226506 198 17590849 SGTC_3096 9117468 49.47 µM 0.848571780215788 0.253699512476572 no 885 0.198059807589884 213 41316311 SGTC_400 oxethazaine 37.5 µM 0.846042867716712 0.254314539114523 no 886 0.198764415285673 227 4621 A local anesthetic. SGTC_2176 5809774 33.9695 µM 0.844919798305796 0.254587917836942 no 887 0.199077809814056 193 2870539 SGTC_1243 0416-0003 5.65 µM 0.84491013899767 0.254590269783249 no 888 0.199080506551903 214 2141977 SGTC_2043 5101342 149 µM 0.842594451957219 0.255154445008374 no 889 0.199727647509793 225 678451 SGTC_2461 5755302 26.15 µM 0.841644938188767 0.255385965713422 no 890 0.199993363676423 238 2788904 SGTC_1256 0570-0116 285 µM 0.840491363636554 0.255667390370602 no 891 0.2003164709357 220 410638 SGTC_1290 0986-0249 10.2 µM 0.837525755834489 0.256391619092246 no 892 0.201148552907141 243 53329 SGTC_1224 0823-0416 294 µM 0.835815663572703 0.256809724818152 no 893 0.20162930661366 220 3598164 SGTC_2781 5567276 71.43 µM 0.835177677808058 0.256965798767405 no 894 0.201808838007546 230 2853274 SGTC_2743 auranofin 4.32 µM 0.833725715379945 0.257321184146799 no 895 0.20221778189095 177 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_2931 9014674 55.67 µM 0.833455757699528 0.25738728770727 no 896 0.202293869841507 229 2996810 SGTC_530 4358-1714 28 µM 0.833369089095519 0.257408511805775 no 897 0.202318301139843 231 1564641 SGTC_1531 st059297 52.4 µM 0.833257205615566 0.257435912068677 no 898 0.202349842952073 234 7566702 SGTC_896 0964-0007 44.5 µM 0.832864270480546 0.257532153883364 no 899 0.202460641194941 212 6756758 SGTC_725 1497-0963 19 µM 0.832857946560318 0.257533702957347 no 900 0.202462424684656 228 3549977 SGTC_2673 kobusone 100 µM 0.832021158047157 0.257738720917266 no 901 0.202698500975679 265 6710676 An epoxy ketone and protein crosslinker. SGTC_1961 st076550 68.7 µM 0.83123379755392 0.257931706064233 no 902 0.202920782683476 245 1579337 SGTC_1624 st003710 6.25 µM 0.829557745728015 0.258342762445948 no 903 0.203394437615288 228 24207033 SGTC_633 0437-0093 97.7 µM 0.829549317665865 0.258344830309113 no 904 0.203396821064783 220 2831118 SGTC_270 tamoxifen 5.46 µM 0.829178683668142 0.258435775517935 no 905 0.203501652553207 243 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_2955 9076254 12.21 µM 0.825505957450407 0.259337875195842 no 906 0.204542200927012 213 16459619 SGTC_3160 9100216 49.47 µM 0.825377153253688 0.259369541750302 no 907 0.20457875080991 226 17191039 SGTC_3169 9102970 49.47 µM 0.825146199022366 0.259426326926481 no 908 0.204644296837498 229 17027839 SGTC_2755 lomerizine 42.69 µM 0.824156465389113 0.259669747411359 no 909 0.204925329919932 213 3949 A calcium channel blocker. SGTC_98 0074-0023 107.663 µM 0.823901350249471 0.259732510925271 no 910 0.204997806582667 214 3563821 SGTC_1186 1319-0216 26 µM 0.822941408388956 0.25996874628507 no 911 0.205270656745696 235 4565136 SGTC_2819 7996655 46.38 µM 0.822251215271218 0.260138666711625 no 912 0.205466967827573 203 6456960 SGTC_1191 1487-1166 10.6 µM 0.821302448651352 0.260372339421552 no 913 0.205737006645846 235 3955771 SGTC_526 4469-0568 170 µM 0.821089427890155 0.260424819384187 no 914 0.205797665748738 214 2901964 SGTC_2289 7946404 165.07 µM 0.820896523676725 0.260472348118364 no 915 0.205852605683619 224 1246120 YPR165W RHO1 SGTC_1835 st008666 49.2 µM 0.81917126981802 0.260897623592303 no 916 0.20634435207227 211 690455 SGTC_421 streptovitacin 30 mM 0.817399738107078 0.261334677889628 no 917 0.206850012658166 228 91467 include heat shock SGTC_353 1988-1175 58.3 µM 0.81554422234135 0.261792854789374 no 918 0.207380431068708 233 2788357 SGTC_2251 lansoprazole 556 µM 0.815044053780632 0.261916430370185 no 919 0.207523546907035 212 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_2796 7949634 45.45 µM 0.813056431517776 0.262407803411443 no 920 0.208092852222655 241 2971588 SGTC_2255 7941087 197.44 µM 0.811361956587014 0.262827078006709 no 921 0.208578919835397 217 935561 SGTC_1270 0831-1170 17.3 µM 0.811079137847446 0.262897090974996 no 922 0.208660112773462 222 6764716 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.810503283366189 0.263039675642364 no 923 0.208825489367371 215 5357218 A potent inhibitor of glutathione S-transferases. SGTC_3017 9080681 49.47 µM 0.810341797654113 0.263079667467864 no 924 0.208871879454083 237 16451914 SGTC_911 3456-4043 236 µM 0.808682987658828 0.26349065042978 no 925 0.209348758088968 233 914281 SGTC_2107 5363541 170.161 µM 0.808649209235741 0.263499022697501 no 926 0.20935847544206 229 244052 SGTC_719 2810-4230 27.3 µM 0.805966048282455 0.264164500281609 no 927 0.210131212936176 224 721079 SGTC_458 nppb 133 µM 0.805165218238227 0.264363287906979 no 928 0.210362172398589 218 4549 A chloride channel blocker. SGTC_2614 arthonioic acid 13.39 µM 0.805069425997888 0.264387071223951 no 929 0.210389808866415 225 6710684 SGTC_2407 paclitaxel 400 µM 0.804255909789419 0.264589095085101 no 930 0.210624597646858 240 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_61 0978-8327 98.565 µM 0.804117253710678 0.264623535956853 no 931 0.210664630484197 229 6150059 YHR072W ERG7 SGTC_978 1416-0512 87.4 µM 0.802741691785736 0.26496533614377 no 932 0.211062025019663 235 6814003 SGTC_439 amiodarone 34.4 µM 0.802501432773741 0.265025058806211 no 933 0.211131479969449 233 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_1252 0493-0875 34.8 µM 0.802348754479786 0.26506301454374 no 934 0.211175623726099 207 3960963 SGTC_3024 9090631 49.47 µM 0.798856146808886 0.265932028256347 no 935 0.212186914777394 225 25236383 SGTC_1139 k015-0024 46.9 µM 0.797611856819819 0.266241974838452 no 936 0.212547884122773 244 2766652 SGTC_689 0833-0039 98 µM 0.79617198616192 0.266600867703121 no 937 0.212966038896319 277 5374726 SGTC_735 3076-0345 636 µM 0.796159023046397 0.266604099916339 no 938 0.212969805711138 245 2888990 SGTC_1581 himbacine 57.9 µM 0.795366594081921 0.266801721161823 no 939 0.213200143090394 244 5281825 An alkaloid muscarinic receptor antagonist. SGTC_2469 5655019 90.81 µM 0.794776648572549 0.266948893780214 no 940 0.213371718383236 241 2788239 SGTC_750 4073-0104 132 µM 0.79084937025083 0.267929668608116 no 941 0.214515948062166 223 22330957 SGTC_769 0302-0231 76 µM 0.788582808991609 0.268496530675642 no 942 0.215177940897594 262 571869 YER009W NTF2 SGTC_14 0354-0009 295 µM 0.788545356034916 0.268505902640416 no 943 0.215188889704237 261 1713507 SGTC_668 1682-0499 62.6 µM 0.787038174467614 0.268883185583715 no 944 0.215629759759242 244 682214 SGTC_1053 3366-3204 134 µM 0.786924935483787 0.268911542708522 no 945 0.215662904762342 259 3632071 YPR165W RHO1 SGTC_2419 paclitaxel 166.5 µM 0.785479153778556 0.269273724964215 no 946 0.216086344002372 244 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_631 k072-0230 41.5 µM 0.785098464951047 0.269369131859896 no 947 0.216197919840598 235 5773147 SGTC_249 wiskostatin 11.211 µM 0.78506350890863 0.269377893269885 no 948 0.216208166756062 230 2775510 A n-wasp and actin depolymerizer. SGTC_2769 toremifene 3.73 µM 0.784516719287207 0.269514959645173 no 949 0.216368487719046 244 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2428 5615643 7.78 µM 0.784158544525197 0.269604763972404 no 950 0.216473543319028 254 2253075 SGTC_1473 k844-0725 134 µM 0.782639574622891 0.269985778303444 no 951 0.216919397555541 261 54682906 SGTC_3283 9109332 35.8195 µM 0.780980601276262 0.270402218359262 no 952 0.217406952085027 213 17027281 SGTC_2064 5220758 200 µM 0.779002373955103 0.270899217719462 no 953 0.217989158164148 246 788518 SGTC_568 1193-0097 7.48 µM 0.778732985396149 0.270966932723038 no 954 0.218068510574986 234 3646150 SGTC_3035 9091303 49.47 µM 0.775123551693358 0.271875033800285 no 955 0.219133328024327 249 25237002 SGTC_1846 st056244 14.8 µM 0.773940294230575 0.272173059938016 no 956 0.219483049855146 246 5393182 SGTC_1877 wortmannin 25 µM 0.773539589946961 0.272274021808039 no 957 0.219601554057522 247 312145 A covalent inhibitor of PI 3-kinase. SGTC_162 k030-0015 37.8 µM 0.773517460539068 0.272279598098974 no 958 0.219608099674585 265 1809920 YMR134W ERG29 SGTC_1583 clindamycin 39.6 µM 0.771933707831575 0.272678828185199 no 959 0.220076845865705 249 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_2681 menadione 3.18 µM 0.771750108431215 0.272725128439325 no 960 0.220131223216028 271 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_2735 sertaconazole 140 nM 0.770221449435278 0.273110778359608 no 961 0.220584271201679 271 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_999 SEC7.066 22.7 µM 0.769558196886993 0.273278187667228 no 962 0.220781005115517 254 740511 YDR170C SEC7 SGTC_3083 9117465 49.47 µM 0.76071726986707 0.275514538168054 no 963 0.223412978704421 268 16420915 SGTC_1685 st024049 53.0905 µM 0.759940097580059 0.275711556818475 no 964 0.223645196025483 251 1941139 SGTC_2958 9077254 16.72 µM 0.758693401289725 0.276027747686972 no 965 0.224017992579833 244 16457351 SGTC_4 0960-0234 25.671 µM 0.758352856881345 0.276114148537391 no 966 0.224119886098589 243 6821112 SGTC_767 0929-0023 86 µM 0.756653057335847 0.276545609727739 no 967 0.22462887268285 270 1204563 SGTC_2377 9073351 62.6 µM 0.755156936017623 0.276925644429726 no 968 0.225077412068995 258 7337946 YHR072W ERG7 SGTC_430 0958-0115 16.4 µM 0.753664194665117 0.277305075246021 no 969 0.225525443468732 246 6833180 SGTC_2953 9074162 66.49 µM 0.752603711032115 0.277574787490489 no 970 0.225844043473248 235 16451992 SGTC_2861 9024595 19.48 µM 0.75043382701464 0.278127052081697 no 971 0.22649673207891 221 16482810 SGTC_408 cantharidin 100 µM 0.749996265460112 0.278238482265669 no 972 0.226628476988195 233 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_3215 9129942 49.47 µM 0.749703841643476 0.278312963554305 no 973 0.226716546648053 268 17682944 SGTC_1043 0916-0009 19.3 µM 0.749299459782972 0.278415976927571 no 974 0.226838366670834 253 3101130 SGTC_288 1315-0019 35.1 µM 0.748623578405592 0.27858819432054 no 975 0.227042058327465 270 6811474 SGTC_1297 1068-0111 14.1 µM 0.745955499554325 0.279268538133145 no 976 0.227847148647025 260 767057 SGTC_2899 9053889 58.44 µM 0.745950877754692 0.279269717364004 no 977 0.227848544663139 243 6470052 SGTC_710 3448-4187 58 µM 0.745825216717049 0.279301780125416 no 978 0.227886502465613 243 3946412 SGTC_3031 9088762 49.47 µM 0.742854435701242 0.280060303658677 no 979 0.228784907116147 257 205253 SGTC_1382 3002-2117 298 µM 0.741049742456392 0.280521579351372 no 980 0.229331640278621 281 1497314 SGTC_350 k064-0020 19.8 µM 0.740634803090525 0.280627688923595 no 981 0.229457449951244 246 2790705 SGTC_2859 9028643 45.46 µM 0.740358299307284 0.280698408102138 no 982 0.229541307406628 227 17151580 SGTC_1231 0242-0792 125 µM 0.739943774881139 0.280804443871058 no 983 0.229667055618192 255 3707635 SGTC_3009 9080819 71.4286 µM 0.739036211813287 0.281036667025257 no 984 0.22994250442334 242 17027216 SGTC_2070 5230947 200 µM 0.737954101196272 0.281313673837844 no 985 0.230271170603124 278 2835538 SGTC_2906 7926292 26.41 µM 0.737161711229299 0.281516599337068 no 986 0.230512007342879 271 2966319 SGTC_3351 9150312 21.596 µM 0.735758065515513 0.281876236372815 no 987 0.230938972776298 266 4904905 SGTC_988 1497-1057 103 µM 0.735415705146676 0.281963988280259 no 988 0.23104317998663 271 3533044 SGTC_729 4092-0585 94.1 µM 0.735268097178864 0.282001826393791 no 989 0.231088116806653 257 2169061 SGTC_948 3448-0295 75.3 µM 0.734700475316271 0.282147354465946 no 990 0.231260965390307 254 678569 SGTC_652 0437-0092 114 µM 0.732105075868668 0.28281322855375 no 991 0.232052217970954 245 3091274 SGTC_903 1134-0042 114 µM 0.731572110968978 0.28295005906329 no 992 0.23221488789887 269 701009 SGTC_106 0092-0003 11.579 µM 0.730947104832598 0.283110560220856 no 993 0.232405731188865 249 1072148 SGTC_2765 myclobutanil 7.74 µM 0.730691254052453 0.283176275130417 no 994 0.232483879427119 279 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_3309 9129340 25.759 µM 0.730464735993846 0.283234462079178 no 995 0.232553080338521 254 17158987 SGTC_899 1083-0020 478 µM 0.728936055578529 0.283627292564347 no 996 0.233020389126812 274 767123 SGTC_647 0140-0236 81 µM 0.726939632866565 0.28414071313813 no 997 0.233631468495378 249 990837 SGTC_1966 st070145 16.1 µM 0.725638298257039 0.284475616821006 no 998 0.234030268177999 267 3748532 SGTC_2369 9071472 200 µM 0.720919440857186 0.285691612718744 no 999 0.235479540461153 267 17296037 SGTC_3043 9092303 49.47 µM 0.719697588967507 0.286006872632307 no 1000 0.235855605531449 249 25236084 SGTC_1203 3992-3522 103 µM 0.718695049351932 0.286265669427977 no 1001 0.236164417152079 273 5322312 SGTC_3312 9133330 71.43 µM 0.716494050771647 0.286834227583972 no 1002 0.236843169843323 274 17617324 SGTC_1006 4099-6547 255 µM 0.715815257796633 0.287009680125973 no 1003 0.23705271492374 282 3146833 SGTC_926 2268-1401 59.4 µM 0.714611105316024 0.287321051158567 no 1004 0.237424690334738 276 2931578 SGTC_3175 9106517 49.47 µM 0.711982841859228 0.288001224903526 no 1005 0.238237700541289 270 41468073 SGTC_752 1896-0090 130 µM 0.711589060306988 0.288103197881991 no 1006 0.238359641643955 261 772567 SGTC_18 0111-0177 500 nM 0.70891064381202 0.288797247566414 no 1007 0.239189964768147 274 721752 SGTC_2920 7982904 15.77 µM 0.707641424965506 0.289126410915972 no 1008 0.23958398051362 252 6456808 SGTC_589 1227-0070 34.1 µM 0.707590585669296 0.289139599418656 no 1009 0.239599770419448 255 2841384 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 0.707534560726367 0.289154133486226 no 1010 0.23961717156552 279 390807 SGTC_2558 carylophyllene oxide 100 µM 0.705737146543061 0.289620603331142 no 1011 0.240175807863004 285 6708694 An oxygenated terpenoid and antifungal agent. SGTC_1429 4049-0205 9.46 µM 0.705624227634403 0.289649920144982 no 1012 0.240210926739895 254 22774478 SGTC_2831 7999036 19.48 µM 0.701613099655845 0.290692220267678 no 1013 0.241460240001422 270 2988270 SGTC_2257 7960413 200 µM 0.698516431486712 0.29149809404715 no 1014 0.242427142782133 261 2974689 YIL048W NEO1 SGTC_2387 9077560 195.08 µM 0.698128038052435 0.291599242655534 no 1015 0.242548562504545 250 5303272 SGTC_541 4513-1321 94 µM 0.696605015069495 0.291996038622815 no 1016 0.243025008234869 265 747515 SGTC_503 tyrphostin 8 294 µM 0.692937037563368 0.292952693841532 no 1017 0.244174532540148 290 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_132 0417-1715 25.805 µM 0.691975496876789 0.293203716288412 no 1018 0.244476358477735 274 6769098 SGTC_1481 3346-2004 36 µM 0.691474264293113 0.293334608969394 no 1019 0.244633774171672 297 2770522 SGTC_2968 9090663 33.37 µM 0.690219569575909 0.293662380635112 no 1020 0.24502805927887 290 25236811 SGTC_2180 6301957 200 µM 0.688781596834195 0.294038239501947 no 1021 0.245480359188592 273 845462 SGTC_1397 3532-0190 20.1 µM 0.688385465525725 0.294141819785961 no 1022 0.245605037083025 250 5322280 SGTC_2821 7996764 71.43 µM 0.688217406292539 0.294185768952382 no 1023 0.245657942118801 230 2987135 SGTC_1066 ketoconazole 628 nM 0.685400179871267 0.294922953056898 no 1024 0.246545715291619 286 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_558 k064-0027 21.3 µM 0.683084749262166 0.295529468746627 no 1025 0.247276645828401 262 5088526 SGTC_174 3553-0389 74.3 µM 0.682002142590864 0.295813248895504 no 1026 0.247618798025751 261 738071 SGTC_464 bw-b 70c 158 µM 0.678320109669987 0.296779343694503 no 1027 0.248784375451081 293 5353454 SGTC_1161 k007-0610 110 µM 0.674763616677612 0.297713868203323 no 1028 0.249912979686664 283 5843850 SGTC_587 k089-0003 57 µM 0.674635178399562 0.297747642487396 no 1029 0.249953788590561 276 9659696 SGTC_1868 st057644 42.7 µM 0.674515421942533 0.29777913536395 no 1030 0.249991842191027 279 688665 SGTC_502 l-744,832 89.3 µM 0.673543176501477 0.298034867197715 no 1031 0.250300894943145 298 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_1456 k015-0012 13 µM 0.671966280341123 0.298449854288241 no 1032 0.250802581575406 287 2989616 SGTC_1394 3474-0001 65.7 µM 0.671500680779465 0.298572435004831 no 1033 0.250950812962967 259 5017666 YIL048W NEO1 SGTC_2476 5806916 10.51 µM 0.671168852355424 0.29865981110059 no 1034 0.251056484367298 275 2870194 SGTC_1291 0993-0025 5.79 µM 0.670959175412642 0.298715028617129 no 1035 0.251123268531456 273 4353356 SGTC_2597 laccaic acid a 100 µM 0.670265538630957 0.298897727926829 no 1036 0.251344265601396 279 5491415 A textile dye. SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.666228208407442 0.299962139952661 no 1037 0.252632622631672 282 551469 SGTC_2236 dapsone 200 µM 0.66435821458214 0.300455730442112 no 1038 0.253230535037587 272 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_3012 9080433 71.4286 µM 0.664211883967196 0.3004943703211 no 1039 0.253277354205997 293 17688859 SGTC_849 0386-0493 241 µM 0.664188572598326 0.300500526099224 no 1040 0.25328481320834 295 726119 SGTC_1338 1486-1223 76 µM 0.663886040903024 0.300580420094736 no 1041 0.253381625575121 272 3444526 SGTC_247 mechlorethamine 29.705 µM 0.661638581950489 0.301174239660995 no 1042 0.254101437462702 266 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_2907 7721985 69.9 µM 0.661306579777532 0.301262005464756 no 1043 0.254207861342992 268 3267881 SGTC_1646 st011709 75.6 µM 0.65917020783452 0.301827037331021 no 1044 0.254893237832324 284 5757843 SGTC_2132 5317594 122.667 µM 0.65879396227009 0.301926596807161 no 1045 0.255014042484524 301 794577 SGTC_3199 9111318 49.47 µM 0.657575114873306 0.302249220968497 no 1046 0.255405594716967 263 8548020 SGTC_2108 5365811 200 µM 0.657564438067191 0.302252047760896 no 1047 0.25540902600667 263 780283 SGTC_303 1348-1668 34.2 µM 0.65663806412136 0.302497359786328 no 1048 0.25570683383339 294 5380509 SGTC_2853 9015042 58.44 µM 0.654884608862743 0.302961934461839 no 1049 0.256271025192039 267 6457456 SGTC_2263 7948595 193.29 µM 0.653131654871466 0.303426695241452 no 1050 0.256835703224192 285 2971371 SGTC_72 0744-0168 198.391 µM 0.649826453717269 0.304303868681137 no 1051 0.257902164619547 304 677577 SGTC_2358 9037157 4 µM 0.648237362452988 0.304726002119322 no 1052 0.258415719961193 285 2388925 SGTC_1904 st060225 78 µM 0.647902332658382 0.30481503418026 no 1053 0.258524060961955 265 66595 SGTC_2283 7944793 200 µM 0.647413741139715 0.30494489502349 no 1054 0.258682102483782 283 2970533 SGTC_934 2950-0684 338 µM 0.647050525780953 0.30504144854702 no 1055 0.258799621796012 289 1121253 SGTC_2449 5812982 45.77 µM 0.646582643111894 0.305165845780618 no 1056 0.258951047207739 289 776185 SGTC_110 0850-0284 111.64 µM 0.64572378820911 0.305394250441877 no 1057 0.259229125987352 266 3906265 SGTC_671 0560-0003 407 µM 0.644871316778062 0.305621032415985 no 1058 0.259505290481129 266 3238678 SGTC_2882 9058044 58.44 µM 0.642352111571318 0.306291649259881 no 1059 0.260322292878486 273 18076804 SGTC_1317 1273-0028 910 nM 0.641532550601617 0.306509957950944 no 1060 0.260588369752264 287 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_1693 xanthone 101.9 µM 0.641370730819323 0.306553070449495 no 1061 0.260640922354929 305 7020 An insecticide. SGTC_2745 rifampicin 24.3 µM 0.641329988918597 0.306563925447465 no 1062 0.260654154556734 264 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_1739 st037196 92.5 µM 0.641102911444214 0.306624429550826 no 1063 0.260727911375857 300 612214 SGTC_195 4234-0266 16.654 µM 0.638024085064822 0.307445293099199 no 1064 0.261729000946963 297 2303354 SGTC_1811 st050069 61.5 µM 0.637870824181073 0.307486180117334 no 1065 0.261778885658842 297 3877702 SGTC_2463 5473429 200 µM 0.636387769469254 0.307881953731681 no 1066 0.262261855289909 287 5399405 SGTC_1415 3966-0071 78.1 µM 0.636346210076697 0.307893047651811 no 1067 0.262275396038373 295 2893185 SGTC_121 0557-0495 61.343 µM 0.63557570174673 0.308098759978852 no 1068 0.262526505450531 307 3104427 SGTC_401 neomycin 50 µM 0.633844923179226 0.308561067553795 no 1069 0.26309101620073 284 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_872 0588-0139 234 µM 0.633411856807858 0.308676791262947 no 1070 0.263232362088711 279 2047100 SGTC_1038 k292-0204 154 µM 0.632758481215478 0.308851421816976 no 1071 0.263445686738812 289 4454212 SGTC_153 4077-0274 519.67 µM 0.632422720098226 0.308941178975721 no 1072 0.263555345785491 291 3121976 SGTC_2550 chrysin dimethyl ether 71.87 µM 0.630909695235546 0.309345789022592 no 1073 0.264049786105815 278 88881 An O-methylated flavonoid and antioxidant. SGTC_2848 9016370 25.97 µM 0.628887331816523 0.309886966485213 no 1074 0.264711410100828 277 7894410 SGTC_2532 xanthone 78.9 µM 0.62724315281217 0.310327246991073 no 1075 0.265249930230769 277 7020 An insecticide. SGTC_3138 9097216 49.47 µM 0.626796807048383 0.310446817032787 no 1076 0.265396218385763 295 25237486 SGTC_2150 5556613 200 µM 0.625439179400722 0.310810630362641 no 1077 0.265841427293768 311 743190 SGTC_2450 5739737 12.93 µM 0.62535662810261 0.310832758204087 no 1078 0.265868510669364 298 2262825 SGTC_2666 tannic acid 100 µM 0.625352322206523 0.310833912416533 no 1079 0.265869923383289 294 16134267 A thiamine antagonist. SGTC_2763 lisinopril 49.32 µM 0.625320786256659 0.310842365809132 no 1080 0.265880270073936 295 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_2740 felodipine 17.08 µM 0.623745824745462 0.311264670215739 no 1081 0.266397261656226 269 3333 L-type calcium channel blocker SGTC_2959 9079155 11 µM 0.62370883238439 0.311274592201178 no 1082 0.266409410755223 315 16189457 SGTC_604 1000-0114 314 µM 0.621299213924446 0.311921188264951 no 1083 0.267201385408426 305 1572745 SGTC_1314 1222-0010 41.1 µM 0.62021135620473 0.312213293751319 no 1084 0.267559322955284 301 3526027 SGTC_302 1094-0063 18.9 µM 0.619230293265516 0.31247682457534 no 1085 0.267882329022667 292 5440289 SGTC_2087 5276107 200 µM 0.617952956729149 0.312820083465629 no 1086 0.2683031746071 293 144405 SGTC_53 0973-0023 39.979 µM 0.617900458705695 0.31283419474514 no 1087 0.268320478305847 320 674768 SGTC_1223 0764-0573 147 µM 0.614926709841248 0.313633974992773 no 1088 0.26930156130695 292 1609797 SGTC_1067 clotrimazole 1.36 µM 0.612468451812963 0.31429577784901 no 1089 0.270113932369192 276 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_2687 chenodiol 100 µM 0.611478694896969 0.314562405243952 no 1090 0.270441359322742 283 5702181 A cholesterol synthesis inhibitor. SGTC_1486 3970-0793 4.53 µM 0.609378486673804 0.315128493799357 no 1091 0.271136797134322 321 2844330 SGTC_1028 k015-0029 4.8 µM 0.608528774320769 0.315357648149871 no 1092 0.271418413874687 299 4588309 SGTC_1602 st001878 87.6 µM 0.608394836001718 0.315393775738283 no 1093 0.27146281780431 316 595405 YLR310C CDC25 SGTC_1012 4112-3522 18 µM 0.603775865132158 0.31664074275244 no 1094 0.2729963337505 307 3112398 SGTC_1865 st057639 52.2 µM 0.602626442305375 0.316951373109682 no 1095 0.273378612793681 309 688818 SGTC_441 propafenone 146 µM 0.602320865089376 0.317033976769472 no 1096 0.273480287311779 311 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_654 1124-0271 80.9 µM 0.601907291770188 0.317145788467619 no 1097 0.273617925111206 304 5403748 SGTC_479 n-linoleoylglycine 10 µM 0.600219068093961 0.317602381602686 no 1098 0.274180123669348 312 6433346 An anti-infammatory. SGTC_3073 9114972 49.47 µM 0.599355776792897 0.31783597271823 no 1099 0.274467830251743 291 41905075 SGTC_1195 1502-0147 41.1 µM 0.598893031040876 0.317961213262525 no 1100 0.274622109491701 287 817940 SGTC_8 0354-0001 70 µM 0.598504350466527 0.318066424412844 no 1101 0.274751728476685 296 4993152 SGTC_740 k014-0057 261 µM 0.5984081550915 0.318092465609388 no 1102 0.274783812808425 321 4012779 SGTC_426 0988-0037 14.6 µM 0.596796826923069 0.318528804327487 no 1103 0.275321518353234 307 5383008 SGTC_1866 st057638 64 µM 0.596250083913271 0.31867691654364 no 1104 0.275504085898722 297 688802 SGTC_1409 3909-8004 61.9 µM 0.59402298712214 0.319280534341684 no 1105 0.276248369178125 292 2119279 SGTC_906 1165-0455 526 µM 0.591722472411149 0.319904554206156 no 1106 0.27701822284303 315 3252859 SGTC_491 tetrandrine 80.3 µM 0.591419328623229 0.319986820715507 no 1107 0.277119746377639 318 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_577 r071-0003 38.6 µM 0.590879441431358 0.320133356062055 no 1108 0.277300600883859 319 4568517 YMR134W ERG29 SGTC_2926 9010726 65.15 µM 0.590608262363691 0.320206969653478 no 1109 0.277391463775448 300 2994293 SGTC_699 0375-0592 111 µM 0.589779948093082 0.320431865586356 no 1110 0.277669093845281 278 762578 SGTC_2717 st081029 62.2815 µM 0.58976705656197 0.320435366292484 no 1111 0.277673415834085 324 5292846 SGTC_2195 6536160 144.242 µM 0.589033469979811 0.32063459866052 no 1112 0.277919410720149 297 3834386 SGTC_3161 9100388 49.47 µM 0.588648000152405 0.320739307861831 no 1113 0.278048713615539 319 25236368 SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.587798480958012 0.320970121994748 no 1114 0.278333781884714 319 165506 SGTC_732 3970-1727 52.7 µM 0.586827369093515 0.321234057590307 no 1115 0.278659826709812 318 1275699 SGTC_1176 0848-0131 83.3 µM 0.582762745313234 0.32233974843399 no 1116 0.280026513722284 313 6769040 SGTC_1860 st056228 74.6 µM 0.582443086313323 0.322426771452527 no 1117 0.280134133365362 343 688679 SGTC_2782 7736369 71.43 µM 0.582320401809932 0.322460173302392 no 1118 0.280175442897078 318 2950836 YOL077C BRX1 SGTC_1736 st036774 51 µM 0.581994106229094 0.322549016891682 no 1119 0.280285325394535 304 1272247 SGTC_2630 antimycin a 100 µM 0.580132223186418 0.323056163185454 no 1120 0.280912727601605 317 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_357 1325-0123 420 µM 0.579145486117666 0.323325067614688 no 1121 0.281245505218086 329 1098503 SGTC_1490 4089-0339 670 nM 0.574627139296971 0.324557579727214 no 1122 0.282771746706541 326 742542 SGTC_1888 azatryptophan 97.5 µM 0.573993048997981 0.324730700773442 no 1123 0.28298625250816 289 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_2314 7727897 200 µM 0.573851248448529 0.324769420724844 no 1124 0.283034232766358 286 900724 SGTC_117 lucigenin 22.078 µM 0.573188903586526 0.324950305186962 no 1125 0.283258398391279 326 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_2990 9074105 71.4286 µM 0.573050797769536 0.324988026686928 no 1126 0.283305149990625 316 6502001 SGTC_2549 cedrol 20.94 µM 0.569748027991107 0.325890661701105 no 1127 0.284424305016502 303 6708665 A sedative which affects the nervous system. SGTC_167 3672-0051 66.205 µM 0.566645311986627 0.326739553490034 no 1128 0.28547759156891 319 3237971 SGTC_2945 9067681 61.76 µM 0.56654739583174 0.326766357627113 no 1129 0.285510861609248 335 16456930 SGTC_145 3737-0113 38.366 µM 0.566009884240189 0.326913515094856 no 1130 0.285693530657301 333 6849351 SGTC_1726 st035556 14.5795 µM 0.565239794080694 0.327124393772558 no 1131 0.285955336538815 296 5919439 SGTC_2654 protoveratrine a 100 µM 0.563711116203402 0.327543164843765 no 1132 0.286475375450554 336 5702278 A heart drug and vasodilator. SGTC_1272 0839-0021 27 µM 0.562956122566003 0.327750070407262 no 1133 0.28673238118281 334 5027250 SGTC_1398 3558-0053 112 µM 0.562850462575929 0.32777903068624 no 1134 0.286768357386306 303 4532369 SGTC_2441 5730946 39.09 µM 0.559966407020772 0.328569919143612 no 1135 0.287751175700881 300 1774275 SGTC_550 4123-0385 25.7 µM 0.55738501775493 0.329278460109203 no 1136 0.288632199824918 315 5731123 SGTC_1708 st033234 31.827 µM 0.557155281303627 0.329341548050409 no 1137 0.288710670049137 286 674664 SGTC_309 k408-0051 1.48 µM 0.555924307849317 0.329679668478472 no 1138 0.28913130010212 337 3640463 SGTC_1111 tnp00062 510.699 nM 0.554812939487803 0.329985055738427 no 1139 0.28951130782289 302 676306 SGTC_180 1486-1293 102.781 µM 0.554229039286653 0.330145548133708 no 1140 0.289711053466043 317 4140536 SGTC_1185 1319-0113 81.3 µM 0.554030089701219 0.330200239098686 no 1141 0.289779126634378 327 4672763 SGTC_2929 9013348 24.6 µM 0.549946256589226 0.331323679321658 no 1142 0.291178118033212 325 2995952 SGTC_2789 5281112 71.43 µM 0.549581720083407 0.331424035353121 no 1143 0.291303149812722 312 765948 SGTC_2772 vinpocetine 57.06 µM 0.546093058076187 0.332385067063241 no 1144 0.292500985690099 361 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_2984 9022109 38.96 µM 0.545960304856612 0.332421658796533 no 1145 0.292546611830679 335 6459207 SGTC_2004 4023728 41.89 µM 0.545600374509498 0.332520877044917 no 1146 0.292670333433864 345 360084 YDR527W RBA50 SGTC_1804 st050076 49.1 µM 0.544562948118015 0.332806919203958 no 1147 0.293027071829613 312 3895976 SGTC_2262 9014885 67.46 µM 0.543074273372147 0.333217550875476 no 1148 0.293539332507476 322 6457424 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 0.54272107272911 0.333315006077967 no 1149 0.293660931515373 340 279621 SGTC_2083 5306046 65.942 µM 0.542381926961564 0.333408593847038 no 1150 0.293777713685549 313 539837 SGTC_754 3474-0146 171 µM 0.54166191913349 0.333607315431194 no 1151 0.294025713910515 297 24762078 SGTC_1496 4469-0713 57.4 µM 0.541188120911039 0.333738108838038 no 1152 0.294188962230013 347 746691 SGTC_468 gf-109203x 121 µM 0.54073828597052 0.33386230580908 no 1153 0.294343992685359 299 2396 A protein kinase C inhibitor. SGTC_2003 4023581 200 µM 0.537643071195896 0.334717370596199 no 1154 0.295411744347616 332 16641307 SGTC_2839 9003951 25.97 µM 0.537232433861913 0.334830875256907 no 1155 0.29555353507486 307 2990634 SGTC_1962 st076595 64.5 µM 0.53566748940934 0.335263581330695 no 1156 0.296094188104043 331 279619 SGTC_220 paclitaxel 373.376 µM 0.534892582438778 0.335477923562894 no 1157 0.2963620688958 327 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1740 st038286 13.222 µM 0.534346754560635 0.335628933794653 no 1158 0.296550825060358 301 716786 SGTC_2434 5670830 169.91 µM 0.531381070933482 0.336449891434836 no 1159 0.297577368013789 346 1549830 SGTC_2713 st079149 53.4 µM 0.53012603443307 0.336797544625599 no 1160 0.298012274784514 320 3103253 SGTC_2473 5854593 8.94 µM 0.529310644534209 0.337023487654363 no 1161 0.298294986325957 341 2872951 SGTC_126 0417-1624 672.48 µM 0.529206224392385 0.337052426531717 no 1162 0.298331199638731 373 41912 YDL195W SEC31 SGTC_1749 st037932 54.2 µM 0.529100314125151 0.337081779365841 no 1163 0.298367931777049 357 594497 SGTC_798 1287-0182 476 µM 0.527789757044809 0.337445079863458 no 1164 0.298822633620651 351 1649755 SGTC_1670 st016595 4.04 µM 0.524638212737381 0.338319341812653 no 1165 0.299917358606914 347 597879 SGTC_781 4335-2806 94.4 µM 0.523486083928419 0.338639168961867 no 1166 0.300318016331174 352 845254 SGTC_1684 st024538 14.6195 µM 0.521461613668894 0.339201437067051 no 1167 0.301022619826336 322 6732859 SGTC_619 1652-1634 108 µM 0.518842549625472 0.339929376686416 no 1168 0.301935271657459 331 5400454 SGTC_1861 st057647 17.4 µM 0.51848312893254 0.340029320319979 no 1169 0.30206061408866 358 688668 SGTC_3140 9094243 49.47 µM 0.517395189411487 0.340331910709652 no 1170 0.302440158563419 362 19291112 SGTC_1084 voriconazole 435 nM 0.513996600948749 0.341277827279762 no 1171 0.303627183558506 352 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_2433 5607874 27.82 µM 0.513983857919824 0.341281375881841 no 1172 0.303631638227953 331 2252428 SGTC_2513 baicalein 25.65 µM 0.513823202213229 0.341326115520871 no 1173 0.303687802265666 332 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_2545 solidagenone 89.61 µM 0.513808492809241 0.341330211928927 no 1174 0.30369294479538 317 6708572 An anti ulcer agent SGTC_1916 st067606 49.2 µM 0.513281917317086 0.341476869752579 no 1175 0.303877065551511 341 19590279 SGTC_1055 3448-0672 86 µM 0.509562276603135 0.342513516651089 no 1176 0.305179078959605 315 748378 SGTC_370 0180-0345 38.7 µM 0.509260033691085 0.342597802637112 no 1177 0.305284983978058 317 3989527 SGTC_391 gliotoxin 8.33 µM 0.507463896985572 0.34309884989974 no 1178 0.305914680999796 340 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_2753 fluvastatin 17.09 µM 0.506127249337095 0.343471898046354 no 1179 0.306383661194343 356 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_1091 telmisartan 47.6 µM 0.506093836744028 0.343481225201314 no 1180 0.306395388505315 343 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_554 4483-2211 187 µM 0.501431803732622 0.344783567990221 no 1181 0.308033630845021 337 747107 SGTC_128 0906-2981 13.371 µM 0.50140980829181 0.344789716811073 no 1182 0.308041369169979 343 6740226 SGTC_2596 sinensetin 100 µM 0.501219187634143 0.344843006492892 no 1183 0.308108435941996 335 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_680 0417-1641 114 µM 0.498805260882584 0.345518106945801 no 1184 0.308958290503316 331 2835990 SGTC_433 pimozide 108 µM 0.498751749290897 0.34553307805669 no 1185 0.308977141575001 333 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_2151 5563267 85.4165 µM 0.497721531262481 0.345821352562611 no 1186 0.309340164975216 374 5310824 SGTC_823 0417-1665 178 µM 0.495620511779762 0.346409534525968 no 1187 0.310081089119228 362 3429856 SGTC_833 3852-0053 558 µM 0.494379587639563 0.346757106325192 no 1188 0.310519063557745 342 3123681 SGTC_148 3253-0744 288.01 µM 0.494020303370589 0.346857762745902 no 1189 0.310645920318313 338 6893655 SGTC_1335 1486-0900 202 µM 0.49353089481744 0.346994891936129 no 1190 0.31081875783025 329 X1335 SGTC_1395 3486-0190 4.35 µM 0.49317489386821 0.347094653748908 no 1191 0.310944507894617 354 6748079 SGTC_89 0302-0250 142.109 µM 0.492738202072212 0.347217041954825 no 1192 0.311098790505413 344 4203518 YLR208W SEC13 SGTC_2204 7233102 200 µM 0.489741038573498 0.348057463009767 no 1193 0.31215857898591 354 2172480 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.487854299742359 0.348586898250124 no 1194 0.31282652336467 344 279621 SGTC_1078 idebenone 36.1 µM 0.486826912006668 0.348875316285703 no 1195 0.313190498545553 351 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_3026 9090633 49.47 µM 0.486156645216014 0.349063527030916 no 1196 0.313428053778286 332 25236842 SGTC_2625 euphol 100 µM 0.48544889687046 0.349262302895293 no 1197 0.313678977217876 349 6708538 A triterpene alcohol. SGTC_1448 4255-0083 152 µM 0.48399089869914 0.349671921748156 no 1198 0.314196164143643 373 5399660 SGTC_2708 st078559 56 µM 0.483241270250377 0.349882595090788 no 1199 0.314462217498918 328 17250902 SGTC_1307 1187-1599 12.2 µM 0.483146156300002 0.349909328937459 no 1200 0.314495981630211 345 1538471 SGTC_386 1509-0011 3.07 µM 0.480098134840597 0.350766435056209 no 1201 0.315578807209998 341 3107280 SGTC_2572 astragaloside iv 100 µM 0.479910134725643 0.350819325771999 no 1202 0.315645647233494 328 45006101 An anti-inflammatory agent. SGTC_1816 st051957 91.6 µM 0.47728823696557 0.351557254148271 no 1203 0.316578443045686 340 674121 SGTC_3149 9097855 49.47 µM 0.473114092139652 0.352733213712531 no 1204 0.318065891695287 328 25236625 YMR079W SEC14 SGTC_1180 1193-0155 285 µM 0.47257740697453 0.35288451358781 no 1205 0.318257352199671 353 2921347 SGTC_3120 9124077 49.47 µM 0.471020197800326 0.353323646638762 no 1206 0.318813155714098 376 18774327 YGL155W CDC43 SGTC_901 1112-0062 60.1 µM 0.469233056711601 0.353827861228722 no 1207 0.319451529705605 328 1908457 SGTC_1799 st045822 46.1415 µM 0.465466622270547 0.354891342261408 no 1208 0.320798667043945 363 3674992 SGTC_1978 st071761 42 µM 0.464552407975459 0.355149648526354 no 1209 0.321126010360354 335 5147680 SGTC_281 1672-3440 14.9 µM 0.463998743623798 0.35530611574778 no 1210 0.321324322884548 354 6833000 SGTC_2604 4'-hydroxychalcone 11.32 µM 0.462793751735606 0.355646734394466 no 1211 0.321756105169944 335 5282362 SGTC_26 0302-0163 425.158 µM 0.462743459123823 0.355660953265315 no 1212 0.321774131658433 377 3100915 SGTC_1288 0973-0013 65.5 µM 0.462566816174272 0.355710895855982 no 1213 0.321837449493154 343 4315430 SGTC_661 1304-0007 33.6 µM 0.462002838525503 0.355870366883557 no 1214 0.322039642444557 359 3117130 SGTC_2584 androsterone 48.74 µM 0.460094385896806 0.356410190289148 no 1215 0.32272423680378 320 2754130 A steroid. SGTC_3221 9128209 49.47 µM 0.457356585309268 0.357185104830731 no 1216 0.323707382039238 365 16460723 SGTC_2252 omeprazole 400 µM 0.456204457789241 0.357511382548795 no 1217 0.324121480067977 348 4594 A proton pump inhibitor. SGTC_1992 st073643 23.3 µM 0.453837415976751 0.358182045588332 no 1218 0.324972925598577 351 3161292 SGTC_2327 6189656 200 µM 0.453347319816351 0.358320961191474 no 1219 0.325149331934049 391 5349088 SGTC_3233 9132340 49.47 µM 0.452823361231272 0.358469495692555 no 1220 0.325337970142564 385 17682950 SGTC_3183 9108214 49.47 µM 0.450903918925583 0.35901381193449 no 1221 0.326029399458248 341 4974831 SGTC_2715 st079500 56.4 µM 0.450881123221658 0.359020278072424 no 1222 0.326037614620712 344 28246688 SGTC_2520 obtusaquinone 4.71 µM 0.448644165304378 0.359655000778955 no 1223 0.326844184252097 387 5967872 SGTC_613 3914-0030 117 µM 0.447202439935619 0.360064286646469 no 1224 0.327364449931554 359 1145395 SGTC_667 1498-1044 59 µM 0.446216969022571 0.360344140554555 no 1225 0.32772026327088 376 6739982 SGTC_2121 5257820 149.641 µM 0.445564821008331 0.360529378627658 no 1226 0.327955813377865 338 791256 SGTC_2655 perillic acid 100 µM 0.444919936440495 0.360712585761392 no 1227 0.328188807307738 355 5702197 An apoptosis inducer. SGTC_1678 st019265 80.2 µM 0.443274405029918 0.361180214359473 no 1228 0.328783633283271 370 5367020 SGTC_2423 st077119 87.2 µM 0.443008591664849 0.361255772927996 no 1229 0.328879760135643 334 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_2096 5468907 200 µM 0.442696856528608 0.361344391849495 no 1230 0.328992508232722 346 759785 SGTC_326 k292-0812 17.5 µM 0.442033638772245 0.361532953709142 no 1231 0.329232432020772 376 3579357 SGTC_1629 st005085 44.9 µM 0.441765474833678 0.361609205928561 no 1232 0.32932946222946 358 24207091 SGTC_1044 1222-0021 1.78 µM 0.438260588125476 0.362606322231174 no 1233 0.330598696163807 344 4306703 SGTC_2019 4016004 108 µM 0.437071263500908 0.362944889211684 no 1234 0.331029833450697 362 45595336 SGTC_1287 0971-0001 34.6 µM 0.436755794206765 0.363034712361386 no 1235 0.331144230593188 345 4665869 SGTC_3256 9138902 49.47 µM 0.436652616507952 0.363064091644794 no 1236 0.331181648856829 382 17228773 SGTC_2295 7971645 200 µM 0.43580195359561 0.36330634393502 no 1237 0.33149021316089 384 2978226 YKL099C UTP11 SGTC_3078 9116413 49.47 µM 0.433924373950598 0.363841235618948 no 1238 0.332171679709917 353 17177322 SGTC_341 1486-1430 230 µM 0.43388814961319 0.363851557952577 no 1239 0.332184832781895 368 2054753 YPL210C SRP72 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.431166405260341 0.364627416810802 no 1240 0.333173689606152 369 364106 SGTC_1775 st081588 35.1725 µM 0.429475426616239 0.365109725844383 no 1241 0.333788636580818 360 1426443 YGL099W LSG1 SGTC_527 4476-4215 268 µM 0.429310998683081 0.36515663616745 no 1242 0.333848456851507 343 4418754 SGTC_2814 7977482 42.97 µM 0.428285284913077 0.365449311808854 no 1243 0.334221715466813 364 6456762 SGTC_226 1,3-diallylurea 8.28947 mM 0.426957206226541 0.365828380207744 no 1244 0.33470524868789 352 74537 YKL182W FAS1 SGTC_2847 9005661 71.43 µM 0.42568447041692 0.366191775269942 no 1245 0.335168889771553 354 2991449 SGTC_768 0384-0033 77.3 µM 0.425205918574679 0.366328443791985 no 1246 0.335343285008581 361 3965305 YMR134W ERG29 SGTC_3030 9087619 49.47 µM 0.423547874262171 0.366802091906885 no 1247 0.335947788568817 356 25236973 SGTC_469 w7 172 µM 0.42123719165401 0.367462515319722 no 1248 0.336790944421297 368 45115570 A P450 inhibitor. SGTC_2218 6965428 192.983 µM 0.421026002763688 0.367522895466084 no 1249 0.336868047136917 363 675684 SGTC_2071 5230951 39.92 µM 0.420482718855674 0.367678238578398 no 1250 0.337066425548184 386 1799272 SGTC_2409 alverine citrate 63.97 µM 0.420246149460655 0.367745888480037 no 1251 0.337152822286666 313 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_2172 5754775 163.918 µM 0.419828611858832 0.367865298456884 no 1252 0.337305330791625 352 2263357 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.419476544892695 0.367965994662898 no 1253 0.337433946470166 338 66535 A nucleotide analog. SGTC_3266 9136860 49.47 µM 0.418631313512886 0.368207780000254 no 1254 0.337742800495884 382 4871271 YPR165W RHO1 SGTC_1158 4092-0494 91.8 µM 0.418513693825894 0.368241430212386 no 1255 0.337785788298861 370 1148199 SGTC_998 3996-0085 177 µM 0.415877254247829 0.368995962900492 no 1256 0.338749912221724 365 715391 SGTC_1572 epiandrosterone 68.9 µM 0.415262643468187 0.369171933411781 no 1257 0.338974822475696 379 441302 A steroid. SGTC_1527 coumarin 137 µM 0.413958663827825 0.369545369339187 no 1258 0.339452189930685 417 323 A hepatotoxic, DNA x-linker. SGTC_3262 9137218 49.47 µM 0.412713365710624 0.369902114874669 no 1259 0.339908315578251 346 17650664 SGTC_364 0083-0097 67.7 µM 0.412567977698521 0.36994377206644 no 1260 0.339961583346133 349 5207356 SGTC_793 0488-0545 106 µM 0.411076527505098 0.370371196763696 no 1261 0.340508210426598 375 292548 SGTC_708 3448-5400 146 µM 0.410741059985677 0.370467358220957 no 1262 0.340631207871718 377 3462195 SGTC_2032 5185112 25.99 µM 0.409851457647892 0.370722401095154 no 1263 0.340957458042064 356 5718189 SGTC_1632 st005650 90 µM 0.409522754964038 0.370816652275857 no 1264 0.341078035620016 345 2759605 SGTC_3177 9107506 49.47 µM 0.408384339661152 0.371143137805687 no 1265 0.341495764416214 389 8897194 SGTC_2490 carminic acid 95.39 µM 0.404610292954882 0.372226157022201 no 1266 0.342881995702368 361 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_213 1246-0773 967 nM 0.402897262064024 0.372718071153104 no 1267 0.343511902796818 381 6251622 SGTC_2589 lobaric acid 100 µM 0.402126190689831 0.372939559910741 no 1268 0.343795579308025 353 73157 A novel microtubule depolymerizer. SGTC_102 gallobenzophenone 83.616 µM 0.399271334812548 0.373759976887017 no 1269 0.344846643107365 396 70837 SGTC_1975 st070967 30.8 µM 0.397079657833198 0.374390200759387 no 1270 0.345654360074713 406 261391 SGTC_92 0063-0024 660.874 µM 0.396133270517298 0.374662441418484 no 1271 0.346003357659479 392 3594437 SGTC_1947 st076332 61.6 µM 0.394379837609497 0.375167004309865 no 1272 0.346650313664593 404 24208416 SGTC_2600 tangeritin 87.95 µM 0.393014833863764 0.375559941894444 no 1273 0.34715426265672 380 68077 A bioactive flavone. SGTC_3162 9099653 49.47 µM 0.392607976152027 0.375677087218992 no 1274 0.347304523777029 353 25237511 SGTC_1484 3473-2379 286 µM 0.387955450246086 0.377017487524427 no 1275 0.349024501041015 381 671917 SGTC_194 1486-1323 56.904 µM 0.386136410426304 0.377541960151781 no 1276 0.349697822686099 383 5178754 SGTC_1756 st041558 35.5 µM 0.385067997613491 0.377850114451872 no 1277 0.350093518737717 390 3955792 SGTC_417 st075190 100 µM 0.385043708179789 0.377857120975767 no 1278 0.35010251643683 417 222757 SGTC_1155 4088-0394 48.2 µM 0.380636781154403 0.379129004898286 no 1279 0.351736392388603 380 2326248 SGTC_2040 5100729 123 µM 0.379470713020969 0.37946576368739 no 1280 0.352169174239141 369 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_2902 5787006 60.46 µM 0.374956149469166 0.380770423539754 no 1281 0.353846539504599 368 591003 SGTC_3053 9095903 49.47 µM 0.374362631137018 0.380942045133257 no 1282 0.354067270495994 426 17174018 SGTC_1545 lovastatin 49.4 µM 0.373366231368114 0.38123021646696 no 1283 0.354437944387042 367 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_2166 5933061 31.504 µM 0.372546779827657 0.381467261519323 no 1284 0.354742894569953 383 2877375 SGTC_264 promethazine 12.5 mM 0.372536109900765 0.381470348332557 no 1285 0.354746865884327 415 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.37218638879895 0.381571526930381 no 1286 0.354877039751577 386 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_392 N-ethylmaleimide 8.33 µM 0.371017075929063 0.381909882193635 no 1287 0.355312406623129 359 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_2699 st077704 54.6 µM 0.366708619144418 0.383157364761983 no 1288 0.356918188331658 370 645852 SGTC_774 k060-0086 136 µM 0.359999886037805 0.385102240119803 no 1289 0.359423609393683 400 5911235 SGTC_877 0771-0151 33.1 µM 0.359623805202995 0.385211352829823 no 1290 0.359564239528426 392 6166523 SGTC_2830 7992007 71.43 µM 0.359032590758708 0.385382900840516 no 1291 0.359785354296366 367 1952075 SGTC_1973 st070275 50.2 µM 0.358644913651432 0.385495402212401 no 1292 0.35993037139132 380 17118334 SGTC_1190 1486-1332 13 µM 0.357296944242208 0.385886649092765 no 1293 0.360434758681343 394 4150046 SGTC_1029 k015-0030 64.7 µM 0.356688709234535 0.386063226782477 no 1294 0.360662429508959 380 2208316 SGTC_1503 4585-0012 61.3 µM 0.350137794064605 0.38796652272212 no 1295 0.363117644178753 381 2922052 SGTC_1850 st056238 17 µM 0.349685194861279 0.388098120444837 no 1296 0.363287482919889 421 5393177 SGTC_2232 chlorophetanol 41.5365 µM 0.349623987492068 0.388115918083334 no 1297 0.363310453169749 405 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_556 4058-0063 51.5 µM 0.34866788635977 0.388393959898265 no 1298 0.363669328007053 406 6615692 SGTC_1621 st003705 32.4 µM 0.348298375791223 0.388501431844177 no 1299 0.363808056752892 384 24207032 SGTC_2731 amoxapine 43.43 µM 0.345847248661496 0.389214556575205 no 1300 0.364728757193471 412 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_2364 9055074 200 µM 0.345441092496617 0.389332758741759 no 1301 0.364881394451305 387 6470630 SGTC_233 rapamycin 362 pM 0.344280424422889 0.389670600204667 no 1302 0.365317702265418 371 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_1867 st057372 64 µM 0.343278549956356 0.389962287882263 no 1303 0.365694458073214 388 688837 SGTC_80 0159-0065 512.242 µM 0.342225422128752 0.390268964373234 no 1304 0.366090627459343 397 1548079 SGTC_1931 st074438 57.1 µM 0.341880064243843 0.390369549328031 no 1305 0.366220576535229 424 2787313 SGTC_3261 9137475 49.47 µM 0.33970439044907 0.391003379467442 no 1306 0.367039577537486 399 17027690 SGTC_1658 st012944 20 µM 0.337772302328983 0.391566489663441 no 1307 0.367767391973404 406 24207260 SGTC_3338 9144300 39.5675 µM 0.334473153940922 0.39252855661997 no 1308 0.369011272800131 375 4901274 SGTC_1944 st076371 56.9 µM 0.334443446371661 0.392537222658799 no 1309 0.369022479728149 405 24208455 SGTC_2714 st079313 56.9 µM 0.334030869187723 0.392657581664079 no 1310 0.369178132471603 385 2939799 SGTC_2868 9035608 32.47 µM 0.333573044371601 0.392791152542895 no 1311 0.369350880871359 391 6462614 SGTC_1857 st056007 79.3 µM 0.331045577356887 0.393528770596265 no 1312 0.370305029439594 385 619834 SGTC_2366 9070441 60.58 µM 0.329477773662996 0.393986511997857 no 1313 0.370897295515375 385 6837235 SGTC_2018 5133068 143 µM 0.329096750561749 0.394097778974623 no 1314 0.371041280125163 413 785362 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.327734002034893 0.394495801668089 no 1315 0.371556396055615 441 688667 SGTC_1988 st071872 53.4 µM 0.327717320742711 0.394500674514416 no 1316 0.371562702974554 405 16414116 SGTC_2272 7805186 180 µM 0.3276988328929 0.394506075101599 no 1317 0.371569692963146 443 2956062 YPR165W RHO1 SGTC_2636 apigenin dimethyl ether 100 µM 0.325142772693148 0.395252934621975 no 1318 0.372536509081815 408 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_2120 5538279 151.968 µM 0.323560463185728 0.395715465380888 no 1319 0.37313541238803 388 2058197 SGTC_1235 benzylparaben 21.5 µM 0.322355809651662 0.396067700652372 no 1320 0.373591578815149 430 7180 SGTC_1618 st003135 44.5 µM 0.321830803780911 0.396221236577795 no 1321 0.373790438376215 433 1270615 SGTC_1505 k297-0037 20.6 µM 0.321449240098174 0.396332833495965 no 1322 0.373934986584537 377 4089396 SGTC_1977 st070720 65.3 µM 0.318232940987001 0.397273849545992 no 1323 0.375154123634613 385 682188 SGTC_1410 3909-8106 77.9 µM 0.318071087911213 0.397321219935119 no 1324 0.375215507074973 423 1039210 SGTC_2656 pseudo-anisatin 100 µM 0.317783065976694 0.39740552057151 no 1325 0.375324748385065 423 6708809 A neurotoxin. SGTC_2935 9038016 29.96 µM 0.316483586047985 0.397785922612218 no 1326 0.375817740923469 407 6463195 SGTC_2919 7978188 46.38 µM 0.315698319168293 0.398015844118928 no 1327 0.376115751307799 384 2980291 SGTC_2657 nystatin 74.44 µM 0.315012277042949 0.398216742196216 no 1328 0.376376166174414 392 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1991 st073000 8.92 µM 0.313688450239923 0.398604483045519 no 1329 0.376878836852399 422 4301969 YIL048W NEO1 SGTC_1623 st003709 20.3 µM 0.310812605677161 0.399447144968031 no 1330 0.377971543030719 377 16192618 SGTC_1676 st018489 23.4 µM 0.310619029859775 0.399503882217082 no 1331 0.378045129308307 417 3696235 SGTC_975 1335-0046 28.5 µM 0.310214464021352 0.399622467686076 no 1332 0.37819893601619 410 16486740 SGTC_658 3253-0951 102 µM 0.310023198899391 0.399678534131983 no 1333 0.37827165737675 429 1184878 SGTC_3275 9138069 49.47 µM 0.30899041297722 0.399981315247832 no 1334 0.378664409783023 433 17617007 SGTC_1779 st039427 55 µM 0.308938188541875 0.399996627447411 no 1335 0.378684273255528 419 1124498 SGTC_154 3389-1638 511.116 µM 0.308470879045193 0.400133649389192 no 1336 0.378862027862377 435 5238686 SGTC_3203 9113543 49.47 µM 0.305821645965985 0.400910675014486 no 1337 0.379870223244869 392 17018012 SGTC_1205 4161-2785 76 µM 0.305663033583076 0.400957208832647 no 1338 0.379930610957995 379 3498106 SGTC_349 k015-0014 24 µM 0.30414178990142 0.401403583707856 no 1339 0.380509935087381 394 2196908 SGTC_529 4076-0302 30.3 µM 0.299546523177622 0.402752741094959 no 1340 0.38226154010466 412 5816522 SGTC_2729 fluphenazine 10.66 µM 0.298536908703413 0.40304931689955 no 1341 0.382646705285126 423 3372 An atypical antipsychotic. SGTC_1579 chlormadinone acetate 49.4 µM 0.298519109341266 0.40305454599044 no 1342 0.382653496736041 443 45114258 A steroidal progestin. SGTC_3220 9131269 49.47 µM 0.296033131901167 0.403785045546411 no 1343 0.383602389585512 435 17722206 SGTC_1016 4226-1401 38 µM 0.292768658181176 0.404744814238125 no 1344 0.384849493106298 437 2901613 SGTC_2329 6138490 200 µM 0.292759319852472 0.4047475605703 no 1345 0.384853062277408 426 720019 SGTC_2570 licareol 100 µM 0.29263848604085 0.404783097307814 no 1346 0.384899246640806 407 443158 SGTC_1596 piperlongumine 63 µM 0.292460834852131 0.404835345233171 no 1347 0.384967150361347 388 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_608 k048-0125 159 µM 0.292305956382508 0.404880896995101 no 1348 0.385026352530558 424 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_2595 hexamethylquercetagetin 100 µM 0.290246098081725 0.405486850312142 no 1349 0.385813986059095 443 386331 SGTC_1791 st048313 56.1 µM 0.287016150572167 0.40643746720201 no 1350 0.38704997695291 419 1204976 SGTC_812 4251-0442 148 µM 0.286772274511916 0.406509265669433 no 1351 0.387143346707523 439 5723007 SGTC_2445 5742597 35.57 µM 0.286401827954408 0.406618333207474 no 1352 0.387285187405505 395 1774255 SGTC_1974 st069448 26.9 µM 0.2854459429437 0.40689980002662 no 1353 0.387651256764842 416 6323587 YNR016C ACC1 SGTC_3336 9143619 71.43 µM 0.28543038826877 0.406904380604128 no 1354 0.387657214469162 417 45595730 SGTC_2330 7979373 200 µM 0.284829357046789 0.407081383448792 no 1355 0.387887439865715 385 1863007 SGTC_1127 asiatic acid 681.4 nM 0.281131445936752 0.408170829329698 no 1356 0.389304791500329 405 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_3109 9122853 49.47 µM 0.28053758517576 0.408345853745821 no 1357 0.38953254691796 453 1234709 SGTC_2995 9067767 71.4286 µM 0.280315507934644 0.408411309712656 no 1358 0.389617726963165 409 11673567 SGTC_3321 9137793 26.8275 µM 0.279403732476418 0.408680076955876 no 1359 0.389967503499526 427 4904192 SGTC_2266 7929956 200 µM 0.278934474797584 0.408818418433967 no 1360 0.390147555518513 405 2967153 SGTC_2892 9047358 58.44 µM 0.278862311070092 0.408839693972605 no 1361 0.390175246501607 424 6466771 SGTC_1562 morin hydrate 59.1 µM 0.278251882231144 0.409019673275934 no 1362 0.390409505222463 413 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_1063 disulfiram 1.84 µM 0.275760280659288 0.409754497544318 no 1363 0.391366096322672 404 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_3087 9117406 49.47 µM 0.274443327318681 0.410143022284998 no 1364 0.391871975151197 373 42546093 SGTC_2212 7123476 200 µM 0.274406455311947 0.410153901456454 no 1365 0.391886141361804 428 1085715 SGTC_483 fpl-64176 144 µM 0.271905494574966 0.410891976741719 no 1366 0.392847343149891 435 3423 SGTC_1245 0418-0076 17.2 µM 0.27129464407449 0.411072296982206 no 1367 0.393082212734909 433 6790114 SGTC_2479 5617353 43.85 µM 0.270898932386962 0.411189119272869 no 1368 0.393234383083959 445 2731746 SGTC_856 0433-0016 11.3 µM 0.270863052215143 0.411199712232745 no 1369 0.393248181558377 430 3911780 SGTC_413 propylparaben 100 µM 0.270753860354152 0.411231949516864 no 1370 0.393290174409138 400 7175 A pharmaceutical preservative. SGTC_3086 9117350 49.47 µM 0.270135254026305 0.411414595208991 no 1371 0.393528100578377 417 2679265 SGTC_728 3030-5151 22.5 µM 0.267558785571121 0.412175512657826 no 1372 0.39451947945087 411 3125388 SGTC_2540 epiandrosterone 100 µM 0.265134448005917 0.412891802430746 no 1373 0.395452945484432 418 441302 A steroid. SGTC_2553 4-methylesculetin 85.09 µM 0.26475267193914 0.413004627701217 no 1374 0.395599999230616 407 5319502 SGTC_1208 2323-2347 50.3 µM 0.260073159514438 0.414388132733749 no 1375 0.397403670658605 451 5412760 SGTC_596 1155-0152 116 µM 0.260014098965843 0.414405600903504 no 1376 0.397426449071558 430 280313 SGTC_2315 7733312 200 µM 0.258825692237563 0.414757128498152 no 1377 0.397884866816837 399 726316 SGTC_696 1560-0013 611 µM 0.25700842347165 0.415294803766724 no 1378 0.398586135226293 388 1650269 SGTC_1709 st033179 39.1045 µM 0.253370291656442 0.416371693565721 no 1379 0.399991041314503 431 573381 SGTC_632 0781-2353 4.65 µM 0.25159736300788 0.416896709911816 no 1380 0.400676148543415 438 6811515 YHR007C ERG11 SGTC_881 0833-0569 170 µM 0.250247813216919 0.417296450743617 no 1381 0.401197855816319 399 5418700 SGTC_466 geldanamycin 89.2 µM 0.249864871228658 0.417409894937897 no 1382 0.401345925187027 436 5288382 HSP90 inhibitor. SGTC_1315 1237-0019 3.69 µM 0.248845614028676 0.417711877053681 no 1383 0.401740102883287 441 825140 SGTC_2455 5377712 9.75 µM 0.246998779045444 0.418259174668687 no 1384 0.402454584493259 393 2243908 SGTC_77 0828-0286 12.516 µM 0.245405181343299 0.418731554327367 no 1385 0.403071358762455 402 745345 SGTC_2818 7996756 12.99 µM 0.244090981508238 0.419121202134995 no 1386 0.403580178526867 458 2241621 SGTC_1730 st033808 45.1 µM 0.243555735525329 0.419279920259735 no 1387 0.403787456957059 462 1045166 SGTC_2846 9008642 19.48 µM 0.241512914683686 0.419885804680391 no 1388 0.404578804110694 452 2992898 SGTC_2285 7945142 200 µM 0.240325151766255 0.420238173136179 no 1389 0.405039098994889 448 2970608 SGTC_3113 9123498 49.47 µM 0.240271124546647 0.420254202678725 no 1390 0.405060039343544 453 8897275 SGTC_1758 st042942 75.2445 µM 0.23857493221611 0.420757519600353 no 1391 0.405717602538142 436 669317 SGTC_3307 9126885 69.2785 µM 0.23780822544925 0.420985069676413 no 1392 0.406014919340841 417 24824909 SGTC_1170 0310-0127 64.8 µM 0.237226119684148 0.421157849854121 no 1393 0.406240686998735 454 774975 SGTC_3292 9120825 59.784 µM 0.236207244098971 0.421460308238634 no 1394 0.406635929286251 465 24824900 SGTC_276 colchicine 750 µM 0.235955925964661 0.421534920434096 no 1395 0.406733435276138 452 2833 A microtubule depolymerizer. SGTC_1217 1183-1422 255 µM 0.235634582462291 0.421630326106397 no 1396 0.406858118013979 435 2849664 SGTC_2178 5812956 200 µM 0.234057393276438 0.422098654218881 no 1397 0.407470211236497 432 5403383 SGTC_2091 4-phenylthiadiazole 200 µM 0.233622796162381 0.422227722202818 no 1398 0.407638914324106 427 270010 SGTC_361 000s-0510 1.45 µM 0.231961552383447 0.422721160341751 no 1399 0.408283938065865 406 660 SGTC_2842 9000675 19.48 µM 0.231197046766225 0.422948281735265 no 1400 0.408580862100566 464 2989072 SGTC_3036 9090181 49.47 µM 0.230261753429074 0.423226176033058 no 1401 0.408944189230892 432 25236586 SGTC_1261 0712-0010 12.7 µM 0.228056166726753 0.423881650830195 no 1402 0.409801288024944 459 2840123 SGTC_3248 9135562 49.47 µM 0.226406769639434 0.424371970293903 no 1403 0.410442531606857 408 17650701 SGTC_3230 9131665 49.47 µM 0.224728138966416 0.424871100279642 no 1404 0.411095386364678 459 15943720 SGTC_2193 5925765 200 µM 0.223980009215761 0.425093590686317 no 1405 0.411386429211346 425 877370 SGTC_3025 9087895 49.47 µM 0.223976177456674 0.42509473029563 no 1406 0.411387919995654 439 17173641 SGTC_692 k241-0027 77.8 µM 0.220997333265811 0.425980861549482 no 1407 0.412547254696787 450 3600480 SGTC_334 1502-1024 68.5 µM 0.220316997790251 0.426183296858462 no 1408 0.412812141527014 456 3296216 SGTC_1768 st044301 37.178 µM 0.219744635560039 0.426353619560697 no 1409 0.413035020016825 474 3931349 SGTC_3003 9075612 71.4286 µM 0.218491698736969 0.426726514545131 no 1410 0.413523012768212 455 6501993 SGTC_707 0865-0008 204 µM 0.218363797789247 0.426764583699403 no 1411 0.413572835046739 464 723043 SGTC_1435 4092-0789 56.7 µM 0.217288510657704 0.427084665125858 no 1412 0.41399175518803 462 2248285 SGTC_2801 7907800 81.82 µM 0.214374699883623 0.427952261835415 no 1413 0.415127434809798 476 6620925 SGTC_822 1487-0950 154 µM 0.213758642129111 0.428135739814588 no 1414 0.415367639130724 462 1958375 SGTC_1157 4092-0394 27.6 µM 0.212862440827035 0.42840267954109 no 1415 0.415717129426943 419 3659885 SGTC_723 4182-0001 115 µM 0.21272644024445 0.428443191116815 no 1416 0.415770171206606 457 744821 YLR208W SEC13 SGTC_1449 4112-4002 201 µM 0.21194580510118 0.428675739692068 no 1417 0.416074657478679 421 2059539 SGTC_1327 1436-0082 2.18 µM 0.211382282109342 0.428843626685837 no 1418 0.416294490607893 445 15992205 SGTC_3344 9148862 3.898 µM 0.210809087877729 0.429014408182265 no 1419 0.416518123401404 449 4905352 SGTC_2080 5212524 12.4 µM 0.210061185389211 0.429237263456808 no 1420 0.416809959569804 443 260183 SGTC_1069 diphenylcyclopropenone 8.49 µM 0.207747085504863 0.429926946933458 no 1421 0.417713225364649 459 65057 A dermal irritant. YDR527W RBA50 SGTC_538 2922-0838 53.3 µM 0.205688866702937 0.430540548595807 no 1422 0.418516977848195 426 777039 SGTC_2046 4110841 106 µM 0.205308251639851 0.43065403699267 no 1423 0.418665648751929 470 44119630 YMR134W ERG29 SGTC_2888 9058547 12.99 µM 0.205231106016274 0.430677040283416 no 1424 0.418695783788396 429 16476514 SGTC_993 3909-8757 62.7 µM 0.204333491018251 0.430944708495277 no 1425 0.41904644999175 418 4288324 YLR208W SEC13 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.203133972013779 0.431302453788102 no 1426 0.419515159700287 449 6708514 SGTC_1059 3448-6867 171 µM 0.201197446364525 0.431880123226339 no 1427 0.420272094086772 464 3934407 SGTC_1107 amlodipine 47 µM 0.200177858693605 0.432184326873576 no 1428 0.420670741455568 459 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_918 glabranin 770.725 nM 0.198385419884372 0.432719215358202 no 1429 0.421371761995248 450 124049 Also referred to as licorice root. SGTC_722 3534-0461 190 µM 0.197649783873462 0.432938775043335 no 1430 0.421659540586992 430 658262 SGTC_2606 farnesol 9.78 µM 0.197610943937011 0.432950367879763 no 1431 0.42167473581746 466 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_1830 st055982 50.3 µM 0.196772687500896 0.433200582379804 no 1432 0.422002712722984 472 455313 An antimicrobial agent. SGTC_1433 4060-0023 7.6 µM 0.195068956210661 0.433709218338148 no 1433 0.422669482528848 455 3840627 SGTC_651 3253-0966 34.4 µM 0.194546189483083 0.433865308402716 no 1434 0.422874116279193 436 781462 SGTC_2237 6667747 47.222 µM 0.194524329445965 0.433871835696737 no 1435 0.422882673707075 480 729940 YDL015C TSC13 SGTC_2039 Aminomethylbenzodioxan 200 µM 0.194441087354018 0.433896691519914 no 1436 0.422915260361703 450 15053 SGTC_15 0266-0086 27.098 µM 0.192131103669298 0.434586549208007 no 1437 0.423819755776959 473 1712902 YIL048W NEO1 SGTC_185 k048-0037 25.491 µM 0.191694172968554 0.434717057447524 no 1438 0.42399088532007 465 6827589 SGTC_548 1436-0017 110 µM 0.191080957571162 0.434900232726125 no 1439 0.424231083205976 470 9677137 SGTC_801 0866-0028 10.1 µM 0.188004158232168 0.435819522188709 no 1440 0.425436695754624 479 6849771 SGTC_42 0133-0086 60.653 µM 0.186493812553677 0.436270912160886 no 1441 0.426028765306096 488 162923 Model of phenazepam hydroxylation. SGTC_843 0310-0051 143 µM 0.186049610113464 0.436403684697064 no 1442 0.426202928592815 478 2065037 SGTC_886 0866-0150 153 µM 0.185695820029851 0.436509438020209 no 1443 0.426341653221803 476 271463 SGTC_3131 9127911 49.47 µM 0.184516857329294 0.436861880907978 no 1444 0.426804001980885 436 45595681 SGTC_2050 5263056 171 µM 0.183581919827998 0.437141409767625 no 1445 0.427170723965698 451 763468 YGL055W OLE1 SGTC_3039 9090270 49.47 µM 0.182984502683183 0.437320042783725 no 1446 0.427405089190673 476 17173750 SGTC_2288 7946289 167.31 µM 0.182207479656818 0.437552398661288 no 1447 0.42770995166753 461 1246052 SGTC_1233 0325-0408 14.2 µM 0.181752751708275 0.437688387524444 no 1448 0.427888382744288 472 12874 SGTC_2864 9034755 47.6 µM 0.181476672150346 0.437770954207839 no 1449 0.427996721028114 459 4930451 SGTC_813 k007-0158 173 µM 0.18051763570355 0.438057792775922 no 1450 0.428373105263425 489 6523916 SGTC_2555 cholic acid 100 µM 0.180185939692319 0.43815700744231 no 1451 0.428503298137719 453 6708657 Influences liver metabolism. SGTC_192 3455-0609 60.9 µM 0.179232768933321 0.438442135044158 no 1452 0.428877467214507 442 3769639 SGTC_1645 Cervolide 78 µM 0.177159599753405 0.439062404531349 no 1453 0.429691514189844 453 23173 A fragrance. SGTC_2581 avocatin a 64 µM 0.175925340076955 0.439431752667291 no 1454 0.43017629865989 465 6710728 A skin care supplement. SGTC_200 k038-0079 37.545 µM 0.174517492142616 0.439853110877634 no 1455 0.430729392480204 460 3436683 SGTC_885 0865-0106 16.8 µM 0.174182693186317 0.439953323712644 no 1456 0.430860943229857 479 2793380 SGTC_2300 7976697 71.57 µM 0.174056346182153 0.439991143204354 no 1457 0.430910590071971 463 2236109 SGTC_2012 4023501 200 µM 0.172840177423707 0.440355207364019 no 1458 0.431388527629787 474 3477460 SGTC_932 2857-0803 154 µM 0.171893795395687 0.440638544874873 no 1459 0.431760512270209 467 674898 SGTC_2391 6285546 200 µM 0.171530088269708 0.440747443319334 no 1460 0.431903487001555 474 846083 SGTC_979 1426-2828 121 µM 0.171437314892835 0.440775221541718 no 1461 0.43193995801701 473 747872 SGTC_1164 k060-0068 93.7 µM 0.169502975648216 0.441354467951103 no 1462 0.432700515999746 481 5963676 SGTC_1376 2910-0861 41.3 µM 0.168592584926612 0.441627131960325 no 1463 0.433058556721912 454 1112859 SGTC_187 1488-2104 32.728 µM 0.168067314177659 0.4417844642907 no 1464 0.433265161526436 482 2852859 SGTC_980 1473-0395 201 µM 0.168041740550428 0.441792124495742 no 1465 0.433275220870286 494 768876 SGTC_636 0kpi-0074 126 µM 0.167703263140138 0.441893512490516 no 1466 0.433408364468168 461 616434 SGTC_1027 k015-0025 8.67 µM 0.166805209931087 0.442162535031669 no 1467 0.433761659595959 431 3598955 SGTC_1732 st034308 51.822 µM 0.166422150805872 0.442277293081014 no 1468 0.433912371599266 419 830119 SGTC_2238 6671620 73.2395 µM 0.16440702342761 0.442881070783343 no 1469 0.434705367455993 417 729941 SGTC_2663 amphotericin b 100 µM 0.160440242173864 0.444069994425345 no 1470 0.436267145757261 468 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2051 5263410 176 µM 0.159851362941012 0.444246536484795 no 1471 0.436499081239387 488 227584 SGTC_2250 alverine citrate 130 µM 0.159154123234775 0.444455578591046 no 1472 0.43677372371072 494 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_209 4077-0173 175.592 µM 0.156472897306013 0.445259590651351 no 1473 0.437830140451938 480 15993494 SGTC_369 0957-0393 4.5 µM 0.15622732465103 0.445333241176029 no 1474 0.437926919607518 463 6997992 SGTC_2795 7780010 54.55 µM 0.155093110471702 0.445673431625754 no 1475 0.438373956757142 452 953673 SGTC_1355 1499-0035 1.68 µM 0.153454570492827 0.44616495757148 no 1476 0.439019906702092 471 1548538 SGTC_2365 9042475 200 µM 0.152170643671366 0.446550165226659 no 1477 0.439526173623702 469 6464479 SGTC_3134 9127454 49.47 µM 0.149725829778446 0.447283804950541 no 1478 0.440490464337942 490 24262820 SGTC_81 0411-0046 9.971 µM 0.14959254230883 0.447323807061501 no 1479 0.440543046174708 473 12925265 SGTC_1218 1348-1416 30.7 µM 0.14780903813926 0.44785912206466 no 1480 0.441246738144385 463 6787668 SGTC_870 0573-2213 57.6 µM 0.147368939914532 0.447991231263106 no 1481 0.441420410089034 491 3916321 SGTC_691 1548-0686 185 µM 0.145797515784648 0.44846299016374 no 1482 0.442040618532736 495 46495133 SGTC_2060 5238662 140 µM 0.143539751978467 0.449140923251201 no 1483 0.442931959370385 461 790130 SGTC_2095 5432005 200 µM 0.143501014629319 0.449152556119534 no 1484 0.442947254992411 507 783734 SGTC_765 1319-0117 244 µM 0.141441244380119 0.449771170080635 no 1485 0.443760686727678 457 3487746 YGL099W LSG1 SGTC_826 1683-5028 118 µM 0.14120114818108 0.449843286514151 no 1486 0.443855519523464 467 722377 SGTC_3151 9099821 49.47 µM 0.138718302715468 0.450589142462825 no 1487 0.444836377229569 468 17174189 SGTC_2695 st077686 51.995 µM 0.138129569159227 0.450766025894271 no 1488 0.445069008477876 468 2876092 SGTC_3188 9110789 49.47 µM 0.137456018458899 0.450968404402239 no 1489 0.445335177437352 471 849217 SGTC_3135 9127742 49.47 µM 0.137340117529161 0.451003229878628 no 1490 0.44538098082818 500 3643468 SGTC_664 1222-0054 14.9 µM 0.134816145816939 0.451761716510476 no 1491 0.446378619933898 472 6813991 SGTC_1913 st060213 96.1 µM 0.134470049529682 0.451865736780816 no 1492 0.446515446489088 472 688959 SGTC_2318 6029776 164 µM 0.132977816137825 0.452314269723805 no 1493 0.447105462414025 486 818325 SGTC_844 0330-0132 15.3 µM 0.131864726710805 0.45264887989132 no 1494 0.447545644474566 507 2828079 SGTC_2517 totarol 10 µM 0.131503613353763 0.452757442826825 no 1495 0.447688464177856 460 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_286 k060-0067 22.9 µM 0.130682359240619 0.453004352832086 no 1496 0.448013293971029 470 5985051 SGTC_3088 9117578 49.47 µM 0.130571316288551 0.453037739286365 no 1497 0.448057217355887 495 678341 SGTC_217 ketoconazole 989 nM 0.130106548695806 0.453177481083863 no 1498 0.448241064526758 480 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_2168 5727979 200 µM 0.130098422441551 0.45317992445855 no 1499 0.448244279111621 492 695210 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.130057131152262 0.453192339811357 no 1500 0.448260613178467 489 2333 A French combination drug. SGTC_1912 st060209 90.8 µM 0.12919048660131 0.453452930682234 no 1501 0.448603461859617 500 688787 SGTC_5 0352-0601 109.883 µM 0.124407519264785 0.454891476039888 no 1502 0.450496310044683 465 762456 SGTC_260 nsc-65238 3.989 µM 0.122365312131287 0.455505880218705 no 1503 0.451304854467335 464 3246252 SGTC_573 3702-0553 84.7 µM 0.121911164973974 0.455642526279021 no 1504 0.451484686608056 456 1222756 SGTC_1184 1269-1718 139 µM 0.121398477883991 0.455796792430918 no 1505 0.451687711218668 476 5403821 SGTC_3325 9138760 55.175 µM 0.12100445315585 0.455915357931055 no 1506 0.451843754003581 477 43844959 SGTC_1014 4130-3005 69.3 µM 0.119477353446565 0.456374912639408 no 1507 0.452448590419287 473 743608 SGTC_443 clozapine 122 µM 0.118332585102133 0.456719449526321 no 1508 0.452902069796297 512 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_2650 prasterone 100 µM 0.118126451934839 0.456781492162472 no 1509 0.452983732284739 497 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_2029 5175081 200 µM 0.117078876435925 0.457096811119154 no 1510 0.453398774381442 486 1380876 SGTC_147 4466-0538 29.23 µM 0.116831345346518 0.457171321630161 no 1511 0.453496851922705 454 6742687 YHR072W ERG7 SGTC_3092 9117248 49.47 µM 0.115880154829688 0.457457657999498 no 1512 0.453873761938835 510 17141857 SGTC_2800 7887935 81.82 µM 0.114645070310239 0.457829487761299 no 1513 0.454363227132072 477 2961002 SGTC_3284 9108171 64.8615 µM 0.114256827444164 0.457946378295334 no 1514 0.45451710250961 499 8687505 SGTC_319 1348-1596 45.5 µM 0.113679094786783 0.458120326351583 no 1515 0.454746092509999 489 5380505 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.111922681756956 0.458649209407194 no 1516 0.455442356076978 505 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1086 cerivastatin 2.18 µM 0.111541843878634 0.458763895256491 no 1517 0.455593342992351 488 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_1706 st031321 9.9705 µM 0.111100089727463 0.458896929784251 no 1518 0.455768488795554 487 6103185 SGTC_2270 7924575 90.91 µM 0.111099649978615 0.458897062217177 no 1519 0.455768663150588 484 1262135 SGTC_292 k038-0015 474 µM 0.111019307674737 0.458921257846226 no 1520 0.455800518033112 474 46368540 SGTC_1661 st013063 9.66 µM 0.109497821557218 0.459379492325469 no 1521 0.456403824763334 491 721395 SGTC_2362 9071156 126 µM 0.10746350418998 0.459992263277348 no 1522 0.457210638526433 484 653133 SGTC_1937 st074714 47.2 µM 0.106969966563069 0.460140939575905 no 1523 0.457406403112053 479 17250970 SGTC_1324 1418-0026 34.4 µM 0.105706523516101 0.46052157224694 no 1524 0.457907602168313 488 1372513 SGTC_963 1269-2853 151 µM 0.105108801883493 0.460701658192204 no 1525 0.458144737550918 470 3668223 SGTC_2190 6049624 200 µM 0.104894503476472 0.46076622554853 no 1526 0.458229760249281 508 2265554 SGTC_2155 5570423 76 µM 0.104537582631864 0.460873766838938 no 1527 0.458371372510794 489 797402 SGTC_504 lovastatin 124 µM 0.0999713985780733 0.462249821164465 no 1528 0.460183516146501 501 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_130 0136-0219 337.655 µM 0.0991752485115997 0.462489793782059 no 1529 0.460499563391234 518 234244 SGTC_954 1189-0853 2.85 µM 0.0990706388940948 0.462521325843992 no 1530 0.460541092071543 502 2828194 SGTC_329 k048-0121 21.3 µM 0.0977355088901582 0.462923789401333 no 1531 0.461071159254116 483 6832902 SGTC_516 3992-2719 87.3 µM 0.0976985764042577 0.462934922925724 no 1532 0.461085823007564 461 5350887 YDR037W KRS1 SGTC_280 3448-3607 3.04 µM 0.0968589484361145 0.463188041742618 no 1533 0.461419204933518 501 626179 SGTC_1885 st057546 99.9 µM 0.0964154996115815 0.463321732259779 no 1534 0.461595291281319 465 702008 SGTC_510 ag-490 170 µM 0.0949635512171201 0.463759493145806 no 1535 0.462171888978191 508 5328779 SGTC_2170 morpholine 200 µM 0.0944153470070239 0.46392478756848 no 1536 0.462389612557239 491 121171 Reacts with secondary amines. SGTC_1613 st002381 52.1 µM 0.0938809594896673 0.464085921978768 no 1537 0.46260185957645 510 551167 SGTC_2809 7964133 12.99 µM 0.09342592718678 0.464223132975511 no 1538 0.462782596838591 501 1253665 SGTC_1837 st055472 66.5 µM 0.0932696459628032 0.464270259189279 no 1539 0.462844672976553 481 676091 SGTC_2403 6032726 181.2 µM 0.0903196414883415 0.465159918989131 no 1540 0.46401660614504 509 2881040 SGTC_3186 9110464 49.47 µM 0.0901392331799678 0.465214332067613 no 1541 0.464088286265675 498 17018021 SGTC_21 0849-0113 22.993 µM 0.0901262025358651 0.465218262274667 no 1542 0.464093463667413 496 1560156 SGTC_95 0471-0001 561.058 µM 0.0900304154087775 0.46524715298769 no 1543 0.464131522482123 511 4015405 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.0884057011419309 0.465737216905642 no 1544 0.464777115092165 512 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_1721 st082152 9.2685 µM 0.0878909619056353 0.465892489004767 no 1545 0.464981670079652 489 5296051 SGTC_639 0833-0042 114 µM 0.0878573750151238 0.465902620736799 no 1546 0.46499501767653 513 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_1744 st037937 38.9 µM 0.0871116968987029 0.466127565693477 no 1547 0.465291363975532 487 1016152 SGTC_1500 4488-1866 171 µM 0.0867211446895197 0.466245385931483 no 1548 0.465446584351412 519 2900003 SGTC_2448 5185112 27.17 µM 0.0862646831566094 0.466383093180823 no 1549 0.465628006273049 479 5718189 SGTC_1334 1486-0610 236 µM 0.085615983028539 0.466578802704112 no 1550 0.465885846247033 510 3742339 SGTC_2402 5553605 200 µM 0.0852828933184326 0.466679297315502 no 1551 0.466018245567675 499 6758546 SGTC_1549 4'-methoxyflavonol 74.6 µM 0.0843336125537713 0.466965711075025 no 1552 0.466395594314471 514 97141 SGTC_2325 6158266 200 µM 0.0838299757124573 0.467117673622262 no 1553 0.466595807362084 505 3623240 SGTC_3187 9109394 49.47 µM 0.081032189517415 0.467961937436751 no 1554 0.467708176568633 512 17098090 SGTC_1023 4482-3888 16 µM 0.0786611530888379 0.468677537633127 no 1555 0.468651072520101 514 3303168 SGTC_232 clozapine 119 µM 0.0781170685607104 0.468841761615548 no 1556 0.468867464967567 503 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_2879 9041815 71.43 µM 0.0758477261367904 0.469526786395325 no 1557 0.469770122743724 517 4942971 SGTC_2826 7992541 19.48 µM 0.0730192631682269 0.470380713624043 no 1558 0.470895394318359 524 2985066 SGTC_3355 9151058 44.0485 µM 0.0710294530861891 0.47098152917786 no 1559 0.471687157255803 524 17015728 SGTC_595 3909-8003 73.7 µM 0.0704630183533477 0.471152574119902 no 1560 0.471912567218604 517 699517 SGTC_2762 leflunomide 42.06 µM 0.0703717964147269 0.471180120688951 no 1561 0.471948869390961 516 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_48 0382-0018 55 µM 0.0667846277027926 0.472263457035736 no 1562 0.4733765807005 515 762596 SGTC_64 000l-0018 272.079 µM 0.0665500452889237 0.472334308906033 no 1563 0.473469957803832 521 6811119 SGTC_1444 4112-3581 28 µM 0.0664177248673568 0.472374274561662 no 1564 0.473522629478571 515 2877249 SGTC_832 4083-0019 164 µM 0.0661859583305256 0.472444277287942 no 1565 0.473614887944999 521 1990758 SGTC_1172 0370-0043 85 µM 0.0638536650576459 0.473148769777577 no 1566 0.474543373434661 512 376585 SGTC_3167 9103034 49.47 µM 0.063775182961043 0.473172477552244 no 1567 0.4745746195749 507 5127859 SGTC_1445 4239-0156 97.7 µM 0.0637284080218858 0.473186607313209 no 1568 0.474593242193439 523 4008346 SGTC_380 3970-0968 6 µM 0.0623371467881233 0.473606894477957 no 1569 0.475147173563375 523 2891601 SGTC_867 0518-0118 155 µM 0.0618139901173819 0.473764942901023 no 1570 0.475355481145616 526 6848158 SGTC_789 1309-1135 70.6 µM 0.0607380868753641 0.474089991965926 no 1571 0.475783899360127 516 3092424 SGTC_1608 st001473 40.5 µM 0.0606371372829489 0.474120491480496 no 1572 0.475824098326392 524 7292267 SGTC_914 3820-6779 408 µM 0.0606351101872149 0.474121103920737 no 1573 0.475824905535273 524 2893481 SGTC_3204 9114183 49.47 µM 0.0603167772493558 0.474217281636797 no 1574 0.475951669980491 511 17027248 SGTC_2758 dehydroepiandrosterone 69.35 µM 0.0596570507878884 0.474416609126012 no 1575 0.476214389640091 522 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_3118 9124250 49.47 µM 0.0592447868831225 0.474541172382196 no 1576 0.476378568746425 520 1504786 SGTC_2385 9074692 200 µM 0.053249849890316 0.476352784434937 no 1577 0.47876641872883 513 17046906 SGTC_2862 9027634 71.43 µM 0.0528376126188786 0.476477376948342 no 1578 0.478930646403646 525 5012562 SGTC_274 sirtinol 40.1 µM 0.052831040317846 0.476479363346109 no 1579 0.478933264715391 527 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_3226 9131256 49.47 µM 0.0522092392540268 0.476667297764567 no 1580 0.479180985557792 506 17178073 SGTC_3193 9111931 49.47 µM 0.0507992326314593 0.477093480197154 no 1581 0.479742751180372 516 17087244 SGTC_1467 k284-1082 293 µM 0.0502909155263472 0.4772471283521 no 1582 0.479945281485296 510 3334705 SGTC_2115 tiliquinol 12.7705 µM 0.0498188338683237 0.477389826709298 no 1583 0.480133379030775 525 71208 A bioactive hydroxyquinoline. SGTC_1250 0485-0349 40.2 µM 0.049209916252697 0.477573891397813 no 1584 0.480376004407734 517 6842794 YDL195W SEC31 SGTC_3217 9129673 49.47 µM 0.0477858987875192 0.478004364511546 no 1585 0.480943437427618 500 17248312 SGTC_1489 4065-0444 182 µM 0.0468794490497094 0.478278392977373 no 1586 0.481304653682818 535 2877968 SGTC_2103 5378138 10 µM 0.0456380769133909 0.478653688338484 no 1587 0.481799359894445 526 244142 SGTC_3342 9147791 14.508 µM 0.045357451773582 0.478738530410435 no 1588 0.481911197313035 532 1838168 SGTC_3119 9125183 49.47 µM 0.0436737387745334 0.479247591498996 no 1589 0.482582236329454 528 22695334 SGTC_657 3534-0529 86.7 µM 0.0435118163413966 0.479296549627059 no 1590 0.482646772684772 525 1049549 SGTC_930 2810-3379 265 µM 0.042411619775612 0.479629208274447 no 1591 0.483085282721723 519 1015764 SGTC_1119 parthenolide 318.541 nM 0.0412280440680516 0.479987093519188 no 1592 0.483557048370509 521 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_1305 1181-0477 144 µM 0.0372734005276929 0.481182999385692 no 1593 0.485133507027118 526 6252086 SGTC_3315 9136395 68.55 µM 0.0372498419214661 0.481190124155403 no 1594 0.485142899028884 539 16876844 SGTC_2197 6588183 93.1375 µM 0.0362012829835289 0.481507243235221 no 1595 0.485560931494318 527 884136 SGTC_482 fipronil 114 µM 0.034406950640789 0.482049936020404 no 1596 0.486276320472578 532 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_1432 4049-0298 68.4 µM 0.0320662369261908 0.482757930773901 no 1597 0.487209614292929 537 741646 SGTC_2665 lovastatin 100 µM 0.0310013681922481 0.483080039329244 no 1598 0.487634224269451 528 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_730 1436-0052 41.2 µM 0.0306127954927486 0.483197580137142 no 1599 0.487789168802776 516 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_2268 7933382 153.85 µM 0.0302036297269757 0.483321351796875 no 1600 0.487952326875036 531 935025 YOR257W CDC31 SGTC_617 3770-0098 35 µM 0.0275025058686673 0.484138475035664 no 1601 0.48902947060525 537 5962639 SGTC_3291 9121177 71.43 µM 0.0274530793196594 0.484153427806674 no 1602 0.489049181502866 532 17015612 SGTC_2343 7990716 14.84 µM 0.0271393239491247 0.484248347196119 no 1603 0.489174305162946 535 6456862 SGTC_336 4111-0029 111 µM 0.0244910372466037 0.485049559772529 no 1604 0.49023046640667 533 3131175 SGTC_3313 9133968 57.047 µM 0.0244290062646961 0.485068327359971 no 1605 0.490255205786242 539 1494643 SGTC_2171 5739187 198.077 µM 0.019473455393624 0.486567741712068 no 1606 0.492231706277261 537 2262761 SGTC_2495 cafestol 54.53 µM 0.0183729790401385 0.486900742316647 no 1607 0.492670654203041 530 16667697 An anti-infammatory. SGTC_2982 9019404 25.97 µM 0.0182682183924113 0.48693244303143 no 1608 0.492712440641444 528 22333232 SGTC_2760 etidronate 98.04 µM 0.0168760419608185 0.487353725278836 no 1609 0.493267752895736 543 3305 A chelator and antioxidant. SGTC_727 3032-0951 202 µM 0.0167102420805865 0.487403898422559 no 1610 0.493333888151923 536 3652836 SGTC_2835 9006588 71.43 µM 0.0160367874067771 0.487607696377796 no 1611 0.493602521678503 539 2345538 SGTC_385 1494-0393 12.4 µM 0.0150840916412942 0.48789600258491 no 1612 0.493982546275398 538 3090647 SGTC_2950 9072895 21.46 µM 0.014505091224121 0.488071223650811 no 1613 0.494213508741044 532 17332245 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.0140407138993342 0.488211758358165 no 1614 0.494398749619094 540 6728940 SGTC_165 k038-0023 64.381 µM 0.0139227612231622 0.488247454660534 no 1615 0.494445801329408 540 46368543 SGTC_3259 9138485 49.47 µM 0.0130111386100861 0.488523344360786 no 1616 0.49480945314373 532 17646153 SGTC_3238 9133470 49.47 µM 0.0118186999192371 0.488884227347755 no 1617 0.495285130666563 538 3534688 SGTC_2828 7998861 71.43 µM 0.0112909443827903 0.489043951685087 no 1618 0.495495660606518 541 2988188 SGTC_1844 rapamycin 4 nM 0.0111641084137917 0.489082338643484 no 1619 0.495546257648028 541 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_536 3852-0578 10.6 µM 0.00927401525595931 0.489654387905788 no 1620 0.496300256239584 540 2869208 SGTC_578 3460-0051 92 µM 0.00916573913600168 0.489687159049168 no 1621 0.496343450325852 545 2876744 SGTC_1812 st052057 4.327 µM 0.00895826403842045 0.489749954217799 no 1622 0.496426217515774 541 3645418 SGTC_1926 methyl fluorone black 53.6 µM 0.00865920534863505 0.489840468856628 no 1623 0.496545520042348 543 72721 Reacts with homocysteine. SGTC_1574 spiramycin 23.7 µM 0.00824054411476134 0.489967183893545 no 1624 0.496712535745886 541 6419898 An antibiotic and protein synthesis inhibitor. SGTC_855 0428-0020 25 µM 0.0065581044679783 0.490476413326382 no 1625 0.497383713602308 546 6812414 SGTC_2987 9018338 71.43 µM 0.00614443981104335 0.490601620951481 no 1626 0.497548738594214 545 5055682 SGTC_969 1313-0238 134 µM 0.00569518609468375 0.490737601687893 no 1627 0.497727961754398 544 5212874 SGTC_1923 st058458 19.1 µM 0.0055932001638211 0.490768471081041 no 1628 0.497768647606139 545 3534982 SGTC_1616 st002734 56.1 µM 0.00537531539840766 0.490834421249817 no 1629 0.497855569743954 546 4026101 SGTC_2873 9040596 71.43 µM 0.00507820532109991 0.490924352033234 no 1630 0.497974097896242 547 6463863 SGTC_2620 irigenin 100 µM 0.00483533075986167 0.490997866878794 no 1631 0.498070989637015 547 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_206 4546-0025 72.014 µM 0.00274694886109043 0.491630004198876 no 1632 0.498904127335404 548 6620745 YIL048W NEO1 SGTC_2482 5981709 142.65 µM 0.00231508879749285 0.491760727631542 no 1633 0.499076414020811 546 877755 SGTC_136 0097-0015 404.482 µM 0.00149435388101343 0.492009165361487 no 1634 0.499403839276862 547 4861337 SGTC_2638 epoxomicin 18 µM 0.0012321186753782 0.492088545022285 no 1635 0.49950845589029 547 9915668 A protesome inhibitor. SGTC_751 0833-0568 350 µM 0.000936219728803625 0.492178115210117 no 1636 0.499626502420996 547 6954252 SGTC_3212 9128307 49.47 µM 0.000313040437317563 0.492366756186802 no 1637 0.499875114936118 547 27243542 SGTC_1714 st033236 13.627 µM -0.000334638114643474 0.492562815079227 no 1638 0.499866498709927 549 2916566 SGTC_717 1532-0246 73.2 µM -0.000381464066862868 0.492576989841963 no 1639 0.499847817858965 550 9561992 SGTC_2515 chrysin 20.77 µM -0.00040477178606962 0.492584045364332 no 1640 0.499838519425033 549 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_2175 5807670 165.306 µM -0.0011965688810161 0.492823733076869 no 1641 0.499522638195863 549 241186 SGTC_1366 1683-0113 21.9 µM -0.00163005015598695 0.492954954837199 no 1642 0.499349704361581 552 708623 SGTC_35 0133-0054 64.071 µM -0.0027879268758973 0.493305466459513 no 1643 0.498887779535333 549 99677 SGTC_560 2332-1943 155 µM -0.00363982125308452 0.493563354638943 no 1644 0.498547924615296 550 21177716 SGTC_1759 st043059 70 µM -0.00448413889400712 0.493818951819355 no 1645 0.498211093399064 552 669426 SGTC_3191 9110352 49.47 µM -0.00473638809617962 0.493895314791543 no 1646 0.498110461596833 553 17122424 SGTC_2158 5657123 3.6195 µM -0.00600910206840341 0.49428060468315 no 1647 0.497602729544971 554 2858827 SGTC_66 0109-0187 42.4 µM -0.00629426321756077 0.494366932529036 no 1648 0.497488968858784 550 759417 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.0070096226501544 0.494583496978815 no 1649 0.497203588055407 553 1609 A potent and irreversible inhibitor of serine proteases. SGTC_1470 k295-0292 231 µM -0.00772065772790022 0.49479875387639 no 1650 0.496919933799579 553 5045612 SGTC_770 0389-1121 67.2 µM -0.0083111628211288 0.49497752299588 no 1651 0.496684363922892 555 6753108 SGTC_959 1222-0044 107 µM -0.00958595944840523 0.49536345747144 no 1652 0.496175814045709 555 6083612 SGTC_1828 st055811 49 µM -0.0111771056319718 0.495845170289728 no 1653 0.495541072831666 556 5877589 SGTC_358 0075-0058 9.45 µM -0.0112027676059062 0.495852939395989 no 1654 0.495530835826197 557 1069125 SGTC_2360 9040895 200 µM -0.0118254787735193 0.496041464309815 no 1655 0.495282426483955 558 4914414 SGTC_3164 9100705 49.47 µM -0.0124975905381134 0.496244946174395 no 1656 0.495014312517102 552 17174235 SGTC_1773 st048542 73.5835 µM -0.0129474980882149 0.496381156252955 no 1657 0.494834839900197 553 3237138 SGTC_3005 9076496 71.4286 µM -0.0133015207198281 0.49648833734883 no 1658 0.494693617468464 553 21368410 SGTC_2067 5224629 34.075 µM -0.0142775237287401 0.496783825600587 no 1659 0.494304285635525 554 2835000 SGTC_2484 5809818 12.04 µM -0.014905148962457 0.496973842230779 no 1660 0.494053926050742 554 2870548 SGTC_107 0358-0022 2.6945 µM -0.0149929786772672 0.497000433165194 no 1661 0.494018890978981 557 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_2518 prenyletin 46.28 µM -0.0168809103578812 0.497572018003634 no 1662 0.493265810962941 552 3873459 A coumarin with calcium channel inhibitory activity. SGTC_913 3487-1245 167 µM -0.0187322631387946 0.498132533165904 no 1663 0.492527345251757 555 4016153 SGTC_1640 st009078 66.4 µM -0.0188313857446229 0.498162543618142 no 1664 0.492487808027495 558 690618 SGTC_454 lyso-paf C-16 6.67 µM -0.0194283991545889 0.498343296166749 no 1665 0.492249677716041 567 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_1336 1486-0901 104 µM -0.0196003829026592 0.498395366252461 no 1666 0.492181079190274 556 5006114 SGTC_925 2064-1272 59.6 µM -0.0210626775746096 0.498838094035002 no 1667 0.491597828633109 577 6815817 SGTC_3019 9081971 49.47 µM -0.0216433779229459 0.499013908668943 no 1668 0.491366215523393 562 16451803 SGTC_1446 4239-0190 62 µM -0.0223006757771463 0.499212914429991 no 1669 0.491104054912526 557 1340085 SGTC_2949 9072542 2.23 µM -0.0224007300931709 0.499243207237545 no 1670 0.49106414898437 567 16457352 SGTC_638 3970-0837 4.09 µM -0.0225513873227434 0.499288820774885 no 1671 0.491004060625134 553 4118451 YLR208W SEC13 SGTC_205 1486-1330 71.903 µM -0.0228695576481238 0.499385151223492 no 1672 0.490877161759758 557 4118834 SGTC_377 3970-0964 33.1 µM -0.0234987807249388 0.499575657277316 no 1673 0.490626205529017 556 16481235 SGTC_228 caffeine 993.056 µM -0.0236283349883912 0.499614881649169 no 1674 0.490574535202496 562 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_3020 9089140 49.47 µM -0.0249003427728502 0.5 no 1675 0.490067226913393 555 17217859 SGTC_1987 st072290 61.9 µM -0.0255281219264385 0.499809930958227 no 1676 0.489816858869715 561 54697379 SGTC_1743 st037606 46.3785 µM -0.0256861966126348 0.499762071610304 no 1677 0.489753816866544 565 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_910 3454-3003 490 µM -0.02749042324597 0.499215816880139 no 1678 0.489034289052451 559 820824 SGTC_1128 3448-9350 235 µM -0.0279725421390782 0.499069848880169 no 1679 0.488842025386643 559 619386 SGTC_2742 clothiapine 36.27 µM -0.0281072999106851 0.499029049167998 no 1680 0.488788285944104 558 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_1539 benzyladenosine 56 µM -0.0298300674514568 0.49850745936667 no 1681 0.488101289536606 564 92208 A nucleotide analog. SGTC_1905 st060207 84.5 µM -0.0306259241443679 0.498266504430331 no 1682 0.487783933683217 552 1948547 SGTC_2608 thymoquinone 42.66 µM -0.0307096320106451 0.498241160928504 no 1683 0.487750554776499 563 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_3310 9130229 44.1445 µM -0.0322877959988038 0.497763355401219 no 1684 0.487121270756976 588 7761258 SGTC_115 0527-0192 112.043 µM -0.0324195213222023 0.49772347432798 no 1685 0.487068747452933 568 4233931 SGTC_3045 9092950 49.47 µM -0.0331213471534036 0.497510990388999 no 1686 0.486788909760516 572 44120432 SGTC_2511 berberine 10.47 µM -0.0349526385624186 0.496956554296352 no 1687 0.486058753363472 562 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_882 0843-0131 351 µM -0.0369788774999956 0.49634310339082 no 1688 0.485250923766411 577 5425421 SGTC_1970 st070122 35.8 µM -0.0369809774905162 0.496342467615601 no 1689 0.485250086564043 566 102928 SGTC_346 4513-0042 7.16 µM -0.0375765229271991 0.496162165739529 no 1690 0.485012663344429 565 2827372 SGTC_2885 9057732 51.95 µM -0.0379961505218908 0.496035123604994 no 1691 0.484845375626058 581 6471414 SGTC_166 k072-0058 166.424 µM -0.0387788258265444 0.495798169964215 no 1692 0.484533363338412 557 5846229 SGTC_1344 1488-0097 29.1 µM -0.0388433286583046 0.495778641904652 no 1693 0.484507649805061 558 747966 SGTC_2106 5357045 167.29 µM -0.0388712613189653 0.495770185369582 no 1694 0.484496514695285 568 668842 SGTC_2412 st077135 33.4 µM -0.0405083862538436 0.495274553811654 no 1695 0.483843910633521 617 13258915 SGTC_222 nsc-310342 10.666 µM -0.0425328461052129 0.494661668674694 no 1696 0.483036964013867 565 432556 SGTC_847 0342-0274 5.54 µM -0.0425691498168678 0.494650678196814 no 1697 0.483022494033867 585 18097 SGTC_39 0986-0283 58.349 µM -0.0446285427920589 0.494027230583694 no 1698 0.482201695730931 568 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_1129 3453-1384 223 µM -0.0451922484363146 0.493856580378675 no 1699 0.481977036395595 608 1084452 SGTC_1895 st058434 18.3 µM -0.0462551671017599 0.493534806857793 no 1700 0.481553436252157 599 5393175 SGTC_3334 9142812 21.919 µM -0.0478234237074671 0.493060061953564 no 1701 0.480928484246393 574 45283678 SGTC_114 0364-0001 490.298 µM -0.0480032893058799 0.493005613395541 no 1702 0.480856810571987 571 4003655 SGTC_1096 rimcazole 32.2 µM -0.0480561862923637 0.49298960054922 no 1703 0.480835732054152 595 18528119 A dopamine reuptake inhibitor. SGTC_2194 5927483 104.545 µM -0.0495675146926376 0.492532099786101 no 1704 0.480233517158082 566 760979 SGTC_1903 st060211 78.3 µM -0.0503930901290227 0.49228219038174 no 1705 0.479904571335239 556 688960 SGTC_1459 k035-0031 35.7 µM -0.0505816652676192 0.492225107345423 no 1706 0.479829436558923 568 3877128 YMR208W ERG12 SGTC_1824 st053723 68.6 µM -0.0507639442673111 0.492169930346476 no 1707 0.479756811060547 585 675225 SGTC_160 3453-0671 289.699 µM -0.0533564908718682 0.491385166916341 no 1708 0.478723935527604 586 5322268 SGTC_1298 1079-1278 263 µM -0.0535622647589018 0.491322880583038 no 1709 0.47864196084567 581 2840950 SGTC_622 1348-1566 26.3 µM -0.0541113729431118 0.491156670370853 no 1710 0.478423215612959 576 7340407 SGTC_3099 9120367 49.47 µM -0.0551529589549519 0.490841395699223 no 1711 0.47800830258511 561 24824940 SGTC_820 1582-0060 59.9 µM -0.0556228390742226 0.490699170899546 no 1712 0.477821134859223 577 3848840 SGTC_2860 9025725 38.96 µM -0.0556943546937789 0.490677524429013 no 1713 0.477792648412856 616 40546248 SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.0558434410432686 0.490632398805092 no 1714 0.477733263984344 574 23665772 A membrane-active detergent. SGTC_1222 0366-0074 1.18 µM -0.0567776659374585 0.490349629316284 no 1715 0.477361152616035 586 286520 SGTC_2058 5236698 133 µM -0.0574058203419723 0.490159503403817 no 1716 0.477110963343852 580 766665 SGTC_1516 st013856 110 µM -0.0600027031436605 0.48937351909383 no 1717 0.476076740887055 599 5281404 A mutagen and neurotoxin. SGTC_1345 1488-0192 31.4 µM -0.060431169614655 0.48924384137546 no 1718 0.475906117125599 582 658348 SGTC_422 cantharidin 155 µM -0.0634055569811096 0.488343658880319 no 1719 0.474721781163153 567 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_472 calcifediol 10 µM -0.0666973955948671 0.487347470867541 no 1720 0.473411303855603 568 5283731 A vitamin D metabolite. SGTC_1093 fluphenazine 7.97 µM -0.0672434549444219 0.487182227894362 no 1721 0.473193945672935 596 6602611 An atypical antipsychotic. SGTC_2244 6635614 200 µM -0.0672591809139056 0.487177469092541 no 1722 0.473187686090057 567 836499 SGTC_1826 st055655 41.6 µM -0.0673703233642133 0.487143836566659 no 1723 0.473143447010868 573 676168 SGTC_2552 juarezic acid 87.02 µM -0.0682541214466897 0.486876396017082 no 1724 0.472791672347858 584 1549512 SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.0687033088813438 0.486740472502176 no 1725 0.472612892161693 592 16486 A toxic proline analog. SGTC_7 0192-1582 4.227 µM -0.0691218252417263 0.486613831399013 no 1726 0.472446324272261 575 252616 SGTC_296 1222-0039 74.9 µM -0.0701211786931957 0.486311437178971 no 1727 0.472048605016055 589 5984176 SGTC_262 fenpropimorph 62.5 µM -0.0701491406936332 0.486302976273583 no 1728 0.472037477194067 576 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_1590 st077108 57.8 µM -0.0704081518767943 0.486224603450744 no 1729 0.471934401546718 575 5489485 SGTC_1935 st074532 41.6 µM -0.0706795147883792 0.486142493754557 no 1730 0.471826412443092 601 2829742 SGTC_3289 9119912 71.43 µM -0.0723691302419452 0.485631258865513 no 1731 0.471154075429013 602 17014829 SGTC_2028 5153890 36.43 µM -0.0726543521946364 0.485544960225508 no 1732 0.471040587083873 597 2830968 YPR165W RHO1 SGTC_3294 9122953 26.2835 µM -0.0726626760631724 0.485542441710951 no 1733 0.471037275094751 571 16459826 SGTC_3143 9086658 49.47 µM -0.0730747268620003 0.48541777012182 no 1734 0.470873326460036 595 25236626 SGTC_152 4469-0003 551.229 µM -0.0734540986489492 0.485302987273424 no 1735 0.47072238466243 589 697280 SGTC_2999 9069765 71.4286 µM -0.0736704888491247 0.48523751673048 no 1736 0.470636290722956 582 2097066 SGTC_1849 st056239 19.2 µM -0.074722523414568 0.484919221169406 no 1737 0.470217743337751 579 5393181 SGTC_3255 9139072 49.47 µM -0.0752773862896559 0.484751349943749 no 1738 0.469997006774561 578 17646060 SGTC_519 k048-0011 62.8 µM -0.0761308719689995 0.484493137040335 no 1739 0.469657489563041 584 6836379 SGTC_771 0250-0039 27.3 µM -0.0763222739552547 0.48443523131889 no 1740 0.469581352736065 608 3005115 SGTC_311 1315-0136 58 µM -0.077873552560997 0.483965928099699 no 1741 0.4689643187533 593 6759207 SGTC_2162 5663267 200 µM -0.07940162018885 0.483503668533705 no 1742 0.468356589993958 623 6456493 SGTC_2788 5282734 71.43 µM -0.0808322010747764 0.483070920010011 no 1743 0.467787699548363 596 743706 SGTC_1443 4112-3303 14 µM -0.0812213414592241 0.48295320906941 no 1744 0.467632963777882 577 704433 SGTC_2394 5221648 200 µM -0.0816114413092083 0.482835209391783 no 1745 0.467477851399186 593 788586 SGTC_2199 6590217 200 µM -0.0835955161692204 0.482235078345098 no 1746 0.46668901601894 592 703109 SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.0839141779292637 0.482138695166025 no 1747 0.466562333481434 634 61125 An anti-inflammatory. SGTC_3159 9100096 49.47 µM -0.0841495953660472 0.482067490929268 no 1748 0.466468746522084 572 25236875 SGTC_2086 5274770 176.623 µM -0.0856836826721402 0.481603505783492 no 1749 0.465858936880206 588 689278 SGTC_1153 4055-0057 267 µM -0.0862253326812563 0.48143968950273 no 1750 0.465643646565298 584 882706 SGTC_198 3454-2873 16.191 µM -0.0891154577938693 0.480565655569602 no 1751 0.464495076364607 598 710957 SGTC_2870 9038528 12.99 µM -0.0897442204229394 0.480375516903838 no 1752 0.46424523743976 629 6463316 SGTC_835 0312-0010 67.2 µM -0.0900820119535871 0.480273370130989 no 1753 0.464111021739417 588 1626196 SGTC_1337 1486-1011 40.3 µM -0.0908446388625884 0.480042759656739 no 1754 0.463808019993133 582 X1337 SGTC_83 0170-0301 39.027 µM -0.0919186812568539 0.479717991712595 no 1755 0.463381324399823 583 3089716 SGTC_2059 5238311 157 µM -0.0919314588120402 0.479714128127909 no 1756 0.463376248384908 589 703021 SGTC_2908 7930301 100 µM -0.0932147537576183 0.479326104456726 no 1757 0.462866476809315 600 2223178 SGTC_3015 9080845 49.47 µM -0.0944539775766793 0.478951424948561 no 1758 0.462374269755268 602 5296973 SGTC_295 k015-0027 31 µM -0.0947391401026855 0.478865208636393 no 1759 0.462261014236573 608 3887424 SGTC_2254 7938975 95.19 µM -0.0949176084545328 0.478811250846258 no 1760 0.462190135070554 634 2969277 SGTC_1626 st003712 1.76 µM -0.0949991282654751 0.478786604427119 no 1761 0.462157759666823 618 24207035 SGTC_2560 caryophyllene 100 µM -0.0959777220882213 0.478490746096532 no 1762 0.461769133032377 580 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_1460 k062-0059 9.15 µM -0.095996937366708 0.47848493685832 no 1763 0.461761502478764 580 1373085 SGTC_2499 avocadenofuran 51.48 µM -0.0961547826221561 0.478437216635907 no 1764 0.461698821292844 630 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_515 4092-1064 102 µM -0.0973296963969512 0.478082023152845 no 1765 0.461232286817309 641 717353 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.0996866189053337 0.477369544051298 no 1766 0.460296562094004 582 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_1159 4092-0538 61.2 µM -0.100480857981336 0.477129468017411 no 1767 0.459981289518843 590 717301 SGTC_2223 6903751 107.57 µM -0.101413842958265 0.476847463625841 no 1768 0.459610974018497 588 5598863 SGTC_715 0868-0130 184 µM -0.101857736505876 0.476713296256274 no 1769 0.459434798402124 602 2876258 SGTC_1178 0988-0033 191 µM -0.102530413187139 0.476509983939866 no 1770 0.459167836907339 591 5392207 SGTC_1724 st037281 8.293 µM -0.103243892568085 0.476294345946455 no 1771 0.458884702392907 601 574124 YDL195W SEC31 SGTC_1919 st067113 52.3 µM -0.105544401747082 0.475599100593647 no 1772 0.457971919607474 597 1268243 SGTC_456 gingerol 170 µM -0.10583439919809 0.475511464624445 no 1773 0.457856871717991 630 442793 A herb. SGTC_2823 7987624 58.44 µM -0.10626583151684 0.475381089846451 no 1774 0.45768572027557 610 2239440 SGTC_648 0375-0473 33.3 µM -0.107371709282994 0.475046916085634 no 1775 0.457247048728501 608 1713139 SGTC_1392 3455-1037 33.9 µM -0.108048386684917 0.474842446583912 no 1776 0.456978654911353 592 981132 SGTC_3271 9137798 49.47 µM -0.109071979804968 0.474533163250265 no 1777 0.456572699572836 596 6498326 SGTC_403 arphamenine a 50 µM -0.109313836298345 0.474460087441406 no 1778 0.456476786291243 585 5487158 An arginine aminopeptidase inhibitor. SGTC_1003 4049-0218 100 µM -0.109594115463311 0.474375403476982 no 1779 0.456365638863119 589 295161 SGTC_3181 9108277 49.47 µM -0.10973990271597 0.474331355556783 no 1780 0.456307826859747 611 17097298 SGTC_2030 5175110 200 µM -0.110148556555958 0.474207887233452 no 1781 0.456145779921783 634 2831986 SGTC_1784 st039334 36.3 µM -0.110213821749014 0.474188168612107 no 1782 0.456119900441638 598 3496984 SGTC_3048 9093155 49.47 µM -0.111649674713927 0.473754369371754 no 1783 0.455550591747306 585 25236002 SGTC_803 4488-1585 147 µM -0.11171093440959 0.473735862309086 no 1784 0.455526304598497 628 747204 SGTC_2497 7-hydroxyflavone 100 µM -0.112153865121044 0.47360205095283 no 1785 0.455350704300552 628 5281894 SGTC_2971 9092186 9.93 µM -0.112886942313345 0.473380591593623 no 1786 0.455060094338798 585 25236400 SGTC_506 n9-isopropylolomoucine 153 µM -0.113086056377238 0.473320441538434 no 1787 0.45498116473717 582 6610355 SGTC_3107 9121808 49.47 µM -0.113162231816611 0.473297429980261 no 1788 0.454950968961885 597 662681 SGTC_1710 st031758 61.5 µM -0.115645417242157 0.47254734287226 no 1789 0.453966783303527 580 5394341 SGTC_3093 9117344 49.47 µM -0.116025662840297 0.472432491946872 no 1790 0.453816101571193 593 24824913 SGTC_2167 5876490 200 µM -0.11689277501588 0.472170594450452 no 1791 0.453472511802432 598 686534 SGTC_3206 9114350 49.47 µM -0.116947155681196 0.472154170031734 no 1792 0.453450964836789 616 17087243 SGTC_1359 1582-0056 520 nM -0.12033426666239 0.471131266160145 no 1793 0.452109180226754 617 3661189 SGTC_2045 5106652 78.05 µM -0.121904134507839 0.470657231933617 no 1794 0.451487470594127 589 673349 SGTC_3269 9137823 49.47 µM -0.1222725233482 0.470545999957338 no 1795 0.451341595943887 593 17682936 SGTC_1981 st071826 47 µM -0.123910792393072 0.470051366066134 no 1796 0.45069295385639 597 11838600 SGTC_3190 9110366 49.47 µM -0.124731235265769 0.469803671414709 no 1797 0.450368164166427 623 17123768 SGTC_3008 9078912 71.4286 µM -0.126486889394054 0.469273672500443 no 1798 0.449673263220718 633 16648731 SGTC_583 1488-1091 88.9 µM -0.126642641447155 0.469226656504451 no 1799 0.449611622821596 624 4303273 SGTC_1246 0422-0085 105 µM -0.127178066008656 0.469065034181563 no 1800 0.449399732595065 618 264295 SGTC_2110 5483698 200 µM -0.127345894545352 0.469014374800712 no 1801 0.44933331868635 595 2848765 YHR062C RPP1 SGTC_2005 4024620 188 µM -0.127479325850356 0.468974098651255 no 1802 0.449280517626914 599 236743 SGTC_1210 3013-0140 750 nM -0.128213639527715 0.468752452255552 no 1803 0.448989953187591 605 905973 SGTC_1813 st051246 8.6015 µM -0.129004410028511 0.468513775675411 no 1804 0.448677079646085 595 5291959 SGTC_2852 9023854 51.95 µM -0.129591157427185 0.468336686263436 no 1805 0.448444949800227 616 19798528 SGTC_1472 k841-0093 193 µM -0.130320849560658 0.468116462670999 no 1806 0.448156292586117 617 X1472 SGTC_2712 st079126 47.7 µM -0.131342674862523 0.467808088697841 no 1807 0.447752117256638 624 3152970 SGTC_2313 7726885 200 µM -0.131632517455053 0.467720621372144 no 1808 0.447637482051115 604 726423 SGTC_875 0709-0210 25.7 µM -0.133504354723191 0.46715578489659 no 1809 0.446897260265124 614 6251364 SGTC_1281 0884-0031 11.8 µM -0.133949825148737 0.467021371615186 no 1810 0.44672112524667 600 1548255 SGTC_2787 5284540 71.43 µM -0.135832454448851 0.466453361291467 no 1811 0.445976866944706 633 736958 SGTC_2967 9089538 49.85 µM -0.136418455118165 0.466276572221442 no 1812 0.445745242493615 608 728216 SGTC_1488 4013-0813 75.9 µM -0.137400535956911 0.465980305657517 no 1813 0.445357103716807 610 2910057 SGTC_2024 5144227 134 µM -0.138253011699843 0.465723152636623 no 1814 0.445020230017025 610 3475211 SGTC_1296 1068-0102 11.9 µM -0.138996561849557 0.465498869176903 no 1815 0.444726432961123 631 767053 SGTC_1683 st010134 710 nM -0.139283218019174 0.465412405521207 no 1816 0.444613175347423 655 3818134 SGTC_500 h-89 112 µM -0.139390570539217 0.465380025367174 no 1817 0.444570761619553 642 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_1275 0867-0008 21.1 µM -0.140731817206996 0.464975491854272 no 1818 0.44404090436787 626 3422836 SGTC_1367 1812-0510 76.9 µM -0.140913082864235 0.464920823072386 no 1819 0.443969303323573 609 1142582 YDR527W RBA50 SGTC_279 1273-0055 2.93 µM -0.142744432988911 0.464368534687789 no 1820 0.443246011782819 614 2847562 SGTC_2798 7813637 45.45 µM -0.142796251453397 0.464352908557136 no 1821 0.443225548824829 611 956368 SGTC_285 1486-1325 46 µM -0.142918719191522 0.464315977984806 no 1822 0.443177187280044 613 22310230 SGTC_2331 7980721 200 µM -0.143714809922284 0.46407592156504 no 1823 0.44286283799006 624 2981221 SGTC_507 nimesulide 162 µM -0.145572286092804 0.463515861689263 no 1824 0.442129523690078 628 4495 A COX2 inhibitor. SGTC_1441 4106-0040 13 µM -0.145982553044899 0.463392169107224 no 1825 0.441967580761182 595 2904180 SGTC_533 1222-0222 6.71 µM -0.148573448933106 0.462611114565563 no 1826 0.440945112562354 638 3982874 SGTC_2130 NSC 7 2.4545 µM -0.152793844440939 0.461339139091211 no 1827 0.439280426080203 617 21448 SGTC_894 0960-0238 55.9 µM -0.154428952661199 0.460846443068328 no 1828 0.438635763274628 613 6741907 YDL195W SEC31 SGTC_591 4299-0174 154 µM -0.154717878686577 0.460759389183455 no 1829 0.438521867282661 622 5509088 SGTC_621 3584-0052 32.1 µM -0.15564316533818 0.460480611474594 no 1830 0.438157149258708 646 2273927 SGTC_2439 5492030 7.2 µM -0.15617990467991 0.46031890727693 no 1831 0.43794560804757 626 5722370 SGTC_1921 5740136 50 µM -0.156530602735745 0.460213255535653 no 1832 0.437807399522959 658 1774243 SGTC_976 1348-1067 47.6 µM -0.158556591311667 0.459602958864689 no 1833 0.437009115579055 608 5310671 YGL099W LSG1 SGTC_992 3909-8734 162 µM -0.158837417101089 0.45951837206305 no 1834 0.436898484217791 653 4288319 SGTC_1548 st061468 90.8 µM -0.159515948074036 0.459314001093121 no 1835 0.436631197223172 611 390799 SGTC_2324 6149169 200 µM -0.159792955732543 0.459230570518616 no 1836 0.436522086645122 636 2888231 SGTC_1569 carminic acid 40.6 µM -0.15998124127421 0.459173862746966 no 1837 0.436447925588247 600 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_1378 2093-0007 380 nM -0.16052385220754 0.459010444031878 no 1838 0.436234216953938 612 3618014 SGTC_1189 1431-2119 7.28 µM -0.162324593141613 0.458468162745639 no 1839 0.435525124488589 615 3107275 SGTC_2610 ononetin 44.17 µM -0.162613576851095 0.458381144373082 no 1840 0.435411348252341 644 259632 SGTC_3155 9099265 49.47 µM -0.16288545195225 0.458299279541706 no 1841 0.435304312754445 643 25236499 SGTC_2921 7974240 10.71 µM -0.163994917770176 0.457965224542343 no 1842 0.434867572339164 637 2979074 YDR527W RBA50 SGTC_700 3453-2283 142 µM -0.164130716628242 0.457924338172308 no 1843 0.43481412066451 615 565664 SGTC_1511 0906-3109 28.5 µM -0.164432302812858 0.45783353808615 no 1844 0.434695417841508 627 2882180 SGTC_1438 4092-1045 4 µM -0.16506112964197 0.45764422107859 no 1845 0.434447933672123 620 1351342 SGTC_2063 5246145 200 µM -0.165158972541365 0.457614764984389 no 1846 0.434409428447873 647 711240 SGTC_2335 9018011 154.17 µM -0.166458307001743 0.457223615984319 no 1847 0.433898145779325 636 6458208 SGTC_684 1140-0066 328 µM -0.16682014900207 0.457114695165367 no 1848 0.433755782115209 644 6813534 SGTC_294 k038-0071 157 µM -0.167002626245212 0.457059767520759 no 1849 0.433683991250899 620 24152826 SGTC_2221 6807166 181.081 µM -0.167895030790355 0.456791155834156 no 1850 0.433332929746203 613 674925 SGTC_880 0833-0487 87.2 µM -0.16822665132416 0.456691343851508 no 1851 0.433202487498307 608 76075 SGTC_1731 st035964 63 µM -0.169950971357274 0.456172397850483 no 1852 0.432524347399879 669 6739575 SGTC_2133 5320837 200 µM -0.171993606231087 0.455557749597288 no 1853 0.431721277792374 648 2841355 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.17236361422737 0.455446422008582 no 1854 0.43157583783442 618 2724278 An inhibitor of dopamine biosynthesis. SGTC_2376 9072922 81.32 µM -0.172592652816092 0.455377510888776 no 1855 0.431485813716577 664 17087968 SGTC_75 0159-0059 199.013 µM -0.175755703493513 0.454425978166254 no 1856 0.430242935656332 607 5377270 SGTC_1197 1601-0112 267 µM -0.177276104121736 0.453968692514192 no 1857 0.429645759826929 631 7350313 SGTC_2771 fluoxetine 41.05 µM -0.178358319272397 0.453643235532016 no 1858 0.429220790402366 626 3386 A selective serotonin reuptake inhibitor. SGTC_2137 5261020 140 µM -0.179010192488487 0.453447211250739 no 1859 0.428964849259549 636 763655 SGTC_2098 5376439 882.5 nM -0.181837844903035 0.452597042031535 no 1860 0.427854991832324 631 2844116 SGTC_300 r073-0011 5.04 µM -0.182157381195058 0.452500983022788 no 1861 0.42772960912049 620 2735780 SGTC_375 3970-0961 9.27 µM -0.185554985114112 0.451479768280555 no 1862 0.426396878537455 623 2898222 SGTC_802 4112-3352 742 µM -0.185892986384071 0.451378192989503 no 1863 0.426264341197658 613 704594 SGTC_1350 1495-0454 146 µM -0.186562827346399 0.451176903481278 no 1864 0.426001707219017 615 1069057 SGTC_3352 9151559 45.5865 µM -0.187324759829355 0.450947955419295 no 1865 0.425703005524198 609 17159339 SGTC_940 3232-1287 54.8 µM -0.189397780542345 0.450325129926005 no 1866 0.424890531930009 654 1585493 YIL048W NEO1 SGTC_1030 k029-0042 36.7 µM -0.191317135247391 0.44974858139449 no 1867 0.424138568527882 625 6080581 SGTC_1718 roemerine 11.9335 µM -0.191681658540212 0.449639095410509 no 1868 0.423995786968605 643 235224 An aporphine alkaloid with mutagenic activity. SGTC_1889 st059080 5.18 µM -0.193255613781623 0.449166395970825 no 1869 0.423379393028795 648 176925 Isolated from Daphnopsis sellowiana. SGTC_1257 0669-0121 16 µM -0.193511356467375 0.449089596627671 no 1870 0.423279256485936 624 4307855 SGTC_2047 4141938 200 µM -0.193538741314931 0.449081373090804 no 1871 0.42326853418957 620 3807862 SGTC_1783 st039459 87.517 µM -0.195011971983004 0.448639001399603 no 1872 0.422691787634318 668 729761 SGTC_235 0330-0087 5 mM -0.197184619640651 0.447986730197531 no 1873 0.421841533039127 632 46494818 YHR062C RPP1 SGTC_2922 7999257 32.47 µM -0.197268582013473 0.447961525866277 no 1874 0.421808682076232 614 2988377 SGTC_1509 1326-1131 80 µM -0.197296906890348 0.447953023181363 no 1875 0.421797599859956 605 768313 SGTC_2628 lathosterol 100 µM -0.197665098627514 0.447842499959135 no 1876 0.421653549074305 659 6710616 SGTC_2943 9068529 45.32 µM -0.198275146590078 0.447659385628335 no 1877 0.421414897903736 625 3270634 SGTC_2683 piperine 63.03 µM -0.198313191344907 0.447647966338254 no 1878 0.421400015725531 649 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_2368 9071271 200 µM -0.198319011575703 0.447646219375801 no 1879 0.421397739003403 657 27209959 SGTC_2855 9016525 58.44 µM -0.198568479991817 0.447571341520856 no 1880 0.4213001559522 642 43811474 SGTC_2020 4017018 200 µM -0.198678076339504 0.447538446807266 no 1881 0.421257287339779 657 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_3042 9091578 49.47 µM -0.198905213601761 0.447470274013099 no 1882 0.421168445569986 602 25236497 SGTC_2539 epi(13)torulosol 80 µM -0.200287887125605 0.447055313048799 no 1883 0.420627717646155 668 6708597 SGTC_2113 5491891 107.031 µM -0.200603463108305 0.446960612092535 no 1884 0.420504324975572 665 789979 SGTC_1630 st005209 31.3 µM -0.202012550060181 0.446537797237463 no 1885 0.419953456459742 619 3367314 SGTC_2406 ethylparaben 405.7 µM -0.20289643715332 0.446272606412304 no 1886 0.419607989552508 681 8434 A possible steroid mimic. SGTC_2123 5259487 200 µM -0.202989655530594 0.446244639693145 no 1887 0.419571558794803 629 2173474 SGTC_3195 9113082 49.47 µM -0.203891095475475 0.445974209863889 no 1888 0.41921930185051 622 17018038 SGTC_1400 3771-8998 51.5 µM -0.20475960200858 0.445713683747546 no 1889 0.418879975571129 624 670767 SGTC_1604 st002052 72.4 µM -0.205150698307508 0.445596374142457 no 1890 0.418727193585852 621 6254834 YHR062C RPP1 SGTC_94 0334-0113 514.748 µM -0.2053682566505 0.445531119428193 no 1891 0.418642209603437 636 6795178 SGTC_1013 4112-3890 241 µM -0.205408015980243 0.445519194125851 no 1892 0.418626678978957 637 705171 SGTC_2191 5911152 200 µM -0.205704243161752 0.445430346124694 no 1893 0.418510971940373 637 2875902 SGTC_1454 4239-0054 42.6 µM -0.205959977919611 0.445353645299995 no 1894 0.418411087008661 662 1340767 SGTC_1228 0124-0032 52.5 µM -0.206372831054938 0.44522982532334 no 1895 0.418249845855185 648 X1228 SGTC_2563 tomatine 8.54 µM -0.207384680819053 0.444926381155614 no 1896 0.41785472273993 686 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_3076 9116187 49.47 µM -0.207718790065208 0.444826192032932 no 1897 0.417724272659949 671 27241210 SGTC_736 0958-0254 92.6 µM -0.208293897422202 0.444653743221856 no 1898 0.417499748152619 668 6812352 SGTC_2815 7968870 71.43 µM -0.20829795677088 0.444652526043089 no 1899 0.41749816346008 670 2977326 YHR190W ERG9 SGTC_2481 5478948 45.16 µM -0.208324254024647 0.444644640933895 no 1900 0.417487897544687 635 77792 SGTC_878 0828-0289 13.7 µM -0.210772340568105 0.443910689928779 no 1901 0.416532461355009 625 745350 YLR208W SEC13 SGTC_2962 9082311 13.18 µM -0.211791568424775 0.443605175876618 no 1902 0.416134823368536 636 16459453 SGTC_2215 7188065 200 µM -0.212838446076064 0.443291408679101 no 1903 0.415726487542193 648 940217 SGTC_603 3794-0023 45.9 µM -0.212934117254365 0.443262736155256 no 1904 0.415689175419915 666 3802260 SGTC_676 falcarinol 140 µM -0.213410614990884 0.44311993485 no 1905 0.415503350822937 662 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_2475 5812728 15.03 µM -0.213984515995496 0.442947952629797 no 1906 0.415279565985168 643 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_1140 3229-1848 2.98 µM -0.214112462095065 0.442909612195083 no 1907 0.415229678899429 670 2849525 SGTC_1938 st074717 56.4 µM -0.216940763010452 0.442062218345614 no 1908 0.41412725484983 629 17250979 SGTC_2078 5212016 200 µM -0.217151721269216 0.441999023223309 no 1909 0.414045053870371 647 1899708 SGTC_495 decylubiquinone 155 µM -0.217895423381539 0.441776249960207 no 1910 0.413755296545875 676 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_2652 actinonin 100 µM -0.218017287898218 0.441739747641596 no 1911 0.413707820803756 628 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_3148 9097893 49.47 µM -0.219659346200941 0.441247947058058 no 1912 0.413068234189879 636 17174100 SGTC_234 nsc-17383 10.7 µM -0.220084678913617 0.441120573582447 no 1913 0.412902603371712 650 408974 SGTC_2465 5809242 33.21 µM -0.220584086546981 0.440971024823642 no 1914 0.412708146480476 642 2731748 SGTC_3041 9091929 49.47 µM -0.220911240428232 0.440873062406897 no 1915 0.4125807725185 641 25236887 SGTC_340 k038-0059 454 µM -0.223223690136943 0.440180729802955 no 1916 0.41168070750587 636 23733424 SGTC_2346 9031566 143.75 µM -0.224876733774021 0.439685931096676 no 1917 0.411037584757115 653 4771086 SGTC_1040 k898-0338 155 µM -0.225179038347192 0.439595453686763 no 1918 0.410919997847317 672 20969351 SGTC_2240 6690706 185.951 µM -0.225643938163853 0.439456318942187 no 1919 0.410739182157698 622 805876 SGTC_1462 k081-0014 26.5 µM -0.225730959958191 0.439430275978464 no 1920 0.410705338464999 670 3270634 SGTC_3173 9105693 49.47 µM -0.226045987778688 0.439335999971807 no 1921 0.410582826387676 682 17096658 SGTC_290 2043-6722 48.1 µM -0.226551080196928 0.439184851945209 no 1922 0.410386417752466 651 773758 YLR208W SEC13 SGTC_2356 9061756 188.97 µM -0.228089726701017 0.438724469393319 no 1923 0.409788243259381 633 20104043 SGTC_2146 5545642 200 µM -0.228137010817587 0.438710322695507 no 1924 0.409769864087704 645 825326 SGTC_800 3448-7362 155 µM -0.228497461121031 0.438602483950859 no 1925 0.409629764827304 647 15991913 SGTC_366 0181-0206 4.31 µM -0.229480165281675 0.438308503814412 no 1926 0.409247867571093 667 274874 SGTC_3332 9141069 11.198 µM -0.231183507375535 0.437799022494296 no 1927 0.408586121097231 649 17332883 SGTC_2408 sulbentine 18.36 µM -0.232228083606906 0.437486633513118 no 1928 0.408180433175689 631 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_3122 9126309 49.47 µM -0.232818727082992 0.437310014030501 no 1929 0.407951085183638 659 17591206 SGTC_2725 haloperidol 53.21 µM -0.23441932950802 0.436831450504966 no 1930 0.407329726942346 647 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_177 1327-0068 8.361 µM -0.23460126941082 0.436777058198137 no 1931 0.40725911210004 626 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_3194 9111903 49.47 µM -0.234726712938417 0.436739556605059 no 1932 0.407210426487805 673 17087251 SGTC_477 mead ethanolamide 10 µM -0.235500982926019 0.436508099642596 no 1933 0.406909958019889 635 16061185 SGTC_3125 9127534 49.47 µM -0.236770191139137 0.436128735016825 no 1934 0.406417539046287 626 1639235 SGTC_3241 9133421 49.47 µM -0.237185514983275 0.436004608020452 no 1935 0.406256436552174 653 17018221 SGTC_1795 st049545 62.3 µM -0.238639838781636 0.435570006968824 no 1936 0.405692435289134 628 5291882 SGTC_860 0443-0016 25.1 µM -0.238697093711243 0.43555289885121 no 1937 0.405670235253507 654 5337942 SGTC_1458 k015-0034 6.33 µM -0.241263464873116 0.434786176042273 no 1938 0.404675462699833 683 3598957 SGTC_1863 st057641 20.1 µM -0.241573882906654 0.434693452869648 no 1939 0.40455518059477 649 3921635 SGTC_2693 st077581 40.7 µM -0.24265408510628 0.434370819957179 no 1940 0.404136689607095 673 25238761 SGTC_1430 4049-0248 69.1 µM -0.246767183413608 0.433142728768268 no 1941 0.402544204514484 669 22774488 SGTC_2458 5808907 16.39 µM -0.248827174821214 0.432527897187444 no 1942 0.40174723480647 683 2731747 SGTC_2571 chrysanthemic acid 100 µM -0.249912908326425 0.432203911349893 no 1943 0.401327350257055 720 2743 An insecticide. SGTC_814 3342-0569 96 µM -0.251023689653836 0.431872498349388 no 1944 0.400897896881885 653 4346283 SGTC_2898 9056270 58.44 µM -0.251036433836072 0.431868696269653 no 1945 0.400892970384366 640 19154699 SGTC_2393 9031399 185.94 µM -0.253758897390237 0.431056625913177 no 1946 0.39984091466754 684 1526623 YDL150W RPC53 SGTC_1379 2144-0755 36.5 µM -0.254430663101531 0.430856292886953 no 1947 0.399581432234122 668 5392327 SGTC_60 0986-0278 202 µM -0.254768531293528 0.430755541030432 no 1948 0.39945094089733 694 3110598 SGTC_2854 9024559 71.43 µM -0.255868716306437 0.430427498550552 no 1949 0.399026105727494 690 3163529 SGTC_3257 9139206 32.98 µM -0.256600336480277 0.430209377717603 no 1950 0.39874365761227 675 4910041 SGTC_653 0203-0016 55.2 µM -0.256715270381902 0.430175113950052 no 1951 0.398699291229099 680 295302 SGTC_2124 5246320 200 µM -0.256817625527234 0.430144600568129 no 1952 0.398659781555436 674 579342 SGTC_2932 9016711 44.54 µM -0.257408048602033 0.429968596024418 no 1953 0.398431895145314 692 7117328 SGTC_342 k048-0088 23.3 µM -0.257783786780103 0.42985659608283 no 1954 0.398286888989007 640 6820570 SGTC_427 1354-0053 47.3 µM -0.258122199579254 0.429755726911758 no 1955 0.398156299590459 691 6813657 SGTC_3058 9093861 49.47 µM -0.259358149587547 0.429387371888773 no 1956 0.397679458467776 694 17217477 SGTC_2602 kawain 100 µM -0.259631415638888 0.429305937624253 no 1957 0.397574050465046 660 5369129 SGTC_1318 1280-3875 124 µM -0.259826097732021 0.429247923496383 no 1958 0.397498959526847 686 373245 SGTC_2297 7971671 152.32 µM -0.260512479332229 0.429043397984194 no 1959 0.397234245219027 686 909016 SGTC_1047 2043-3044 82 µM -0.262149108942611 0.42855579796269 no 1960 0.396603243389859 726 669592 SGTC_2749 bexarotene 57.39 µM -0.264067721661509 0.427984325776014 no 1961 0.395863867848767 669 82146 An retinoic acid receptor inhibitor. SGTC_2426 5582046 32.21 µM -0.265349980406457 0.427602480177792 no 1962 0.39536993258607 687 2251934 SGTC_2594 a-mangostin 100 µM -0.266359127867725 0.427302012425031 no 1963 0.394981319869288 686 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_2747 doxorubicin 7.63 µM -0.266610321882274 0.427227227424222 no 1964 0.394884603756326 636 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1339 1486-1321 22.7 µM -0.267495073881028 0.426963841598796 no 1965 0.394544003253977 672 3469382 SGTC_1062 mesoridazine 14.2 µM -0.271511533188736 0.425768574740996 no 1966 0.392998815273063 661 4078 A neuroleptic. SGTC_2952 9073731 13.78 µM -0.272217881902511 0.425558441070921 no 1967 0.392727246536046 689 16457353 SGTC_425 3825-7017 13.1 µM -0.272649664188066 0.425429999349663 no 1968 0.392561265611091 694 3397440 SGTC_1854 st056233 32.9 µM -0.272883524029431 0.425360436666186 no 1969 0.392471375977478 696 5393174 SGTC_1207 2099-0101 141 µM -0.27299829045695 0.425326299715193 no 1970 0.392427264849101 703 5837381 SGTC_1123 mangostin 811.285 nM -0.273097572142158 0.425296769108844 no 1971 0.392389106484279 656 5281650 An antioxidant. SGTC_755 1995-0008 37.3 µM -0.276602655786073 0.424254477553889 no 1972 0.39104261260802 658 689533 SGTC_626 0214-0009 33 µM -0.277637302515085 0.423946910030333 no 1973 0.390645397087194 687 3437874 SGTC_681 1642-0006 26.6 µM -0.278953146934771 0.423555818324536 no 1974 0.390140390654622 678 4446530 SGTC_2304 7443016 91.4 µM -0.279487673749593 0.423396969199892 no 1975 0.38993529810593 680 939854 SGTC_2213 7173844 200 µM -0.280443655884626 0.423112904269145 no 1976 0.389568573831215 658 892728 SGTC_1417 3966-0327 90.4 µM -0.281726477021219 0.422731783716775 no 1977 0.389076625378078 671 651118 SGTC_1412 3909-8563 178 µM -0.283310026603645 0.422261417823106 no 1978 0.388469595952617 680 23767530 SGTC_1478 0453-0656 35.7 µM -0.285066904531529 0.421739697490647 no 1979 0.387796442433813 682 5258496 SGTC_786 4544-0069 423 µM -0.285399332643998 0.421640995466359 no 1980 0.387669109379305 660 748821 YLR208W SEC13 SGTC_1622 st003707 19.4 µM -0.285890968236272 0.421495031794762 no 1981 0.387480815739622 689 10140899 SGTC_2886 9058944 51.95 µM -0.288599216296604 0.420691163014682 no 1982 0.386444047649858 656 4949929 SGTC_3123 9126162 49.47 µM -0.292329938505844 0.419584342997797 no 1983 0.38501718520798 645 25239884 SGTC_1972 st070201 17.4 µM -0.292410652497534 0.41956040399738 no 1984 0.384986332232025 662 2829099 SGTC_1265 0819-1001 68.8 µM -0.294396753643988 0.418971439336155 no 1985 0.384227373637575 679 3106768 SGTC_1051 3253-3903 78 µM -0.296534460268626 0.418337719999499 no 1986 0.383410977097256 650 5509239 SGTC_2856 9022925 19.48 µM -0.296583310470379 0.418323240914316 no 1987 0.383392327092725 680 4944862 SGTC_1431 4049-0260 9.09 µM -0.300474084892228 0.417170381563645 no 1988 0.381907780473728 681 3854841 SGTC_2483 5729050 27.16 µM -0.301256454273042 0.416938646550024 no 1989 0.381609471888572 708 2865180 SGTC_1109 tnp00067 928.257 nM -0.302340735176022 0.416617534146853 no 1990 0.381196164123053 670 676295 SGTC_488 nitrendipine 139 µM -0.302492374482312 0.416572630230137 no 1991 0.381138372820151 662 4507 Dihydropyridine L-type calcium channel blocker. SGTC_2382 9035899 200 µM -0.305171914075372 0.415779336491522 no 1992 0.380117611036328 711 6462679 SGTC_597 k018-0003 82.8 µM -0.306620465716846 0.415350626762929 no 1993 0.379566137078855 711 6786234 SGTC_3157 9099274 49.47 µM -0.306625504050355 0.415349135805857 no 1994 0.37956421937605 669 17217662 SGTC_759 3486-0358 89.3 µM -0.307907823024388 0.414969708249928 no 1995 0.379076236448984 702 875103 SGTC_2954 9074818 52.69 µM -0.30828723063941 0.414857459868256 no 1996 0.378931890831274 723 16648742 SGTC_2883 9059145 45.46 µM -0.310525819265489 0.414195311444869 no 1997 0.378080564138452 680 16476510 SGTC_2384 9036245 200 µM -0.310545930961387 0.414189363741916 no 1998 0.378072918412955 698 6462766 SGTC_854 0422-0053 192 µM -0.311093442087496 0.414027453905039 no 1999 0.377864793217493 672 3596728 SGTC_3297 9117502 71.43 µM -0.311232748838125 0.413986260482507 no 2000 0.377811844250075 664 7453720 SGTC_3084 9116877 49.47 µM -0.311800606316353 0.41381835312488 no 2001 0.37759603161456 708 27241325 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.312593363419157 0.413583972511967 no 2002 0.377294810426914 668 17037758 SGTC_2985 9022375 71.43 µM -0.313480402886617 0.413321753582429 no 2003 0.376957853580866 716 4939335 SGTC_2492 derrusnin 100 µM -0.313522156372365 0.41330941173012 no 2004 0.376941995124554 720 1715307 Part of coumarin class of compounds. SGTC_1897 st060201 15 µM -0.317312250170655 0.412189461675943 no 2005 0.37550334150553 682 611878 SGTC_3216 9129716 49.47 µM -0.319130230821965 0.411652512332564 no 2006 0.374813880186303 670 8056934 SGTC_2648 atorvastatin 78.68 µM -0.319620944468118 0.411507606000359 no 2007 0.374627847604927 703 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_1389 3405-0187 19 µM -0.319799165696392 0.411454980769651 no 2008 0.374560290054063 669 799890 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.319950982728119 0.411410153436352 no 2009 0.374502744464736 699 4620898 SGTC_2205 7238770 200 µM -0.319971226716991 0.411404176038685 no 2010 0.374495071279485 684 279867 SGTC_1308 1187-1617 41.4 µM -0.320187305596 0.411340376189088 no 2011 0.374413172866077 688 2882570 SGTC_2865 9030313 51.95 µM -0.320330856178694 0.411297992474521 no 2012 0.374358767325783 670 42562754 SGTC_2073 5212005 126 µM -0.32074231981497 0.411176512413007 no 2013 0.374202836847507 711 691789 SGTC_2267 7931562 200 µM -0.322603092008492 0.410627246633454 no 2014 0.373497925877648 675 934880 SGTC_2956 9076196 2.52 µM -0.323827627524798 0.410265881766505 no 2015 0.373034269270627 708 16423868 SGTC_3354 9151612 71.43 µM -0.324204618256596 0.410154645758296 no 2016 0.372891562946576 706 27261949 SGTC_559 1550-0661 158 µM -0.324680047321596 0.410014374549873 no 2017 0.3727116185787 693 5830875 SGTC_52 0329-0193 875 nM -0.325763794987158 0.409694667297326 no 2018 0.372301536575261 727 3739292 SGTC_378 3970-0959 8.33 µM -0.32699577760292 0.409331303427399 no 2019 0.371835539405212 721 6615653 SGTC_2031 5180455 200 µM -0.327115282682272 0.409296060455234 no 2020 0.371790346609742 678 29949 SGTC_2623 humulene 100 µM -0.328034568674883 0.409024980436194 no 2021 0.371442762720719 695 6187145 An anti-inflammatory. SGTC_2791 5663188 71.43 µM -0.328853832576482 0.408783431694645 no 2022 0.371133085695107 726 54690634 SGTC_2398 5228213 48.84 µM -0.330781076865961 0.408215346861236 no 2023 0.370404927748387 699 80771 YMR134W ERG29 SGTC_1286 0929-0070 131 µM -0.332546727212861 0.407695063566383 no 2024 0.369738231028808 695 1420408 SGTC_2010 4012422 159 µM -0.33274730445186 0.40763596985051 no 2025 0.369662519242099 698 952393 SGTC_1204 4049-0315 18.3 µM -0.333100124017397 0.407532027866643 no 2026 0.369529352886195 685 588402 SGTC_1873 rapamycin 2 nM -0.333629286878476 0.407376146683395 no 2027 0.369329657788172 681 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_1279 0874-0590 65.2 µM -0.333987147033527 0.407270736288523 no 2028 0.369194628759714 682 3523074 SGTC_1757 st041620 31.8375 µM -0.334265733511527 0.407188681198454 no 2029 0.369089522719272 696 5289815 SGTC_1587 estradiol valerate 56.1 µM -0.335787697845491 0.406740472572015 no 2030 0.368515483893077 718 13791 A steroid. SGTC_1908 st060353 56.5 µM -0.336064657597922 0.406658922838778 no 2031 0.368411054574734 728 4227716 SGTC_1644 st010134 20.9 µM -0.336635267641767 0.406490921671359 no 2032 0.368195933319504 726 3818134 SGTC_399 oxolinic acid 75 µM -0.337636020749065 0.40619631773644 no 2033 0.367818746988761 681 4628 A DNA gyrase inhibitor. SGTC_1102 cgs 12066b 26.1 µM -0.337689159626048 0.406180676078359 no 2034 0.367798722373872 675 6438352 A 5-HT1B full agonist. SGTC_2624 nerol 100 µM -0.338512719845484 0.405938276727195 no 2035 0.367488421622715 713 637566 A natural product oil. SGTC_2294 7971431 200 µM -0.338781572623866 0.405859152806514 no 2036 0.367387142078633 736 5741572 SGTC_2710 st078562 53.7235 µM -0.342325407837655 0.404816555486107 no 2037 0.366053008336724 724 17250908 SGTC_508 roscovitine 141 µM -0.344480167356061 0.404182954291715 no 2038 0.365242604276711 698 160355 A CDKinase inhibitor. SGTC_3147 9097027 49.47 µM -0.346053744637897 0.403720406802639 no 2039 0.364651162307728 686 25236841 SGTC_2794 7785382 27.27 µM -0.346341499883884 0.403635836703987 no 2040 0.364543041915899 733 2205081 SGTC_614 0462-0418 107 µM -0.34676277675293 0.40351203326939 no 2041 0.364384771900645 687 5188303 SGTC_1984 st072354 53.1 µM -0.34959354012198 0.402680389351972 no 2042 0.363321879815162 692 5762938 SGTC_3163 9099914 49.47 µM -0.356377249101586 0.40068921601415 no 2043 0.360779032500098 698 16268368 SGTC_2674 ligustilide 100 µM -0.357850933894577 0.400256994942398 no 2044 0.360227435693859 676 5319022 A signalling regulator. SGTC_1148 3909-7663 27.7 µM -0.361623930179594 0.399150960277463 no 2045 0.358816539788106 737 4084526 SGTC_2824 7998404 51.95 µM -0.364406315408148 0.398335836016535 no 2046 0.357777310101491 710 837851 SGTC_1312 1218-2183 165 µM -0.36493014369002 0.398182425396955 no 2047 0.35758177617091 703 6744073 SGTC_418 lividomycin a 100 µM -0.366033756020246 0.397859268241066 no 2048 0.357169943589896 704 72394 An antibiotic. SGTC_1108 betulinic acid 729.144 nM -0.367557108431744 0.397413318933343 no 2049 0.35660175086949 682 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_2940 9060638 45.86 µM -0.370092983432749 0.396671259269879 no 2050 0.355656604973787 702 4027022 SGTC_542 3381-0244 89.3 µM -0.371510915145318 0.396256500302219 no 2051 0.355128513824461 737 1112843 SGTC_3139 9095020 49.47 µM -0.372909620656544 0.395847480195847 no 2052 0.354607855714307 685 25236292 SGTC_179 1273-0063 6.77 µM -0.373463871779997 0.395685433559988 no 2053 0.35440161476183 746 3108139 SGTC_2811 7967822 32.47 µM -0.373467841445183 0.395684273012293 no 2054 0.354400137773874 695 2232244 SGTC_34 0469-0683 81.75 µM -0.37447745347479 0.395389138904008 no 2055 0.354024563945017 692 3690923 SGTC_675 1309-0189 238 µM -0.375003800639165 0.395235298627577 no 2056 0.35382882004125 690 4246530 SGTC_2918 7977171 22.06 µM -0.375950228752582 0.394958718556731 no 2057 0.353476948926132 711 2236483 SGTC_1637 st007924 17.4 µM -0.376004023715555 0.394942999336956 no 2058 0.353456952333219 679 683336 SGTC_2333 9017922 200 µM -0.37712185276574 0.394616401528564 no 2059 0.353041525986612 694 3163164 SGTC_956 1185-0240 191 µM -0.377855930885129 0.39440196508115 no 2060 0.352768810802635 707 1416193 SGTC_1561 5-methoxyflavone 52.9 µM -0.378192793709065 0.394303572545662 no 2061 0.352643689204398 702 94525 SGTC_2502 avocadyne acetate 18.59 µM -0.378464456306037 0.394224228922398 no 2062 0.352542796659973 687 3952079 SGTC_2143 5623677 140.463 µM -0.379302250412914 0.393979564739186 no 2063 0.352231714356529 675 5375313 SGTC_888 0916-0002 6.97 µM -0.379875477654173 0.393812187118519 no 2064 0.352018925620914 699 2802138 YIL048W NEO1 SGTC_1117 retinoic acid 1.10837 µM -0.380324346128241 0.393681134922861 no 2065 0.351852332672544 731 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_2102 5377816 72.7585 µM -0.381460053164236 0.393349606298259 no 2066 0.351430953674269 734 1379702 SGTC_2420 aureobasidin a 50 nM -0.382458372918236 0.393058246768413 no 2067 0.351060699905938 720 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_19 0279-0214 38.434 µM -0.382499218604999 0.393046327232788 no 2068 0.351045554190529 706 3566274 YBR002C RER2 SGTC_407 eburnamonine 100 µM -0.38361255840873 0.392721472499304 no 2069 0.350632815317258 707 3195 SGTC_907 3448-6986 75.5 µM -0.384109302582537 0.392576554592476 no 2070 0.350448718462478 731 590582 SGTC_1200 1643-0193 18.4 µM -0.386240109141177 0.391955091879882 no 2071 0.349659425641125 732 5403974 SGTC_2347 9049783 174.81 µM -0.388479932870398 0.39130213070776 no 2072 0.348830450767324 764 6467988 YPL169C MEX67 SGTC_272 doxorubicin 8.13 µM -0.389037267238135 0.391139702167771 no 2073 0.348624289195169 691 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_594 1487-1584 10.8 µM -0.389044640294225 0.391137553504555 no 2074 0.34862156215367 745 5013332 SGTC_1348 1493-0373 93.8 µM -0.389435924861926 0.391023529741741 no 2075 0.348476850588949 736 3010129 SGTC_129 0088-0017 176.636 µM -0.390105512400892 0.390828427781359 no 2076 0.348229263411097 740 182446 SGTC_2247 cerulenin 830 nM -0.390907619286548 0.390594748995729 no 2077 0.347932760917662 691 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_3258 9138477 49.47 µM -0.393068621404584 0.38996537842326 no 2078 0.347134399582843 708 4970355 SGTC_2350 9023895 38.85 µM -0.393787577332728 0.389756053438074 no 2079 0.34686893838734 704 2997209 SGTC_20 0481-0013 4.944 µM -0.395206768587963 0.389342947896779 no 2080 0.346345148913569 721 182045 SGTC_478 N-arachidonylglycine 10 µM -0.395272343429254 0.389323863050767 no 2081 0.346320953903442 694 5283389 SGTC_415 dibenzyl ketone 100 µM -0.396389233089431 0.388998845466366 no 2082 0.345908953870877 735 7593 SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.396419671091535 0.388989989020438 no 2083 0.34589772840295 709 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_512 prima-1 270 µM -0.396500537596454 0.388966459838176 no 2084 0.345867905672574 720 322968 A re-activator of the apoptotic function of mutant p53. SGTC_2487 5918373 44.05 µM -0.396758077217389 0.388891527983355 no 2085 0.345772934097536 731 2876279 SGTC_41 0478-0632 82.643 µM -0.398649869945753 0.388341232586793 no 2086 0.345075605107566 750 3750424 SGTC_1882 5615643 20 µM -0.399870560543579 0.387986270046637 no 2087 0.344625928310383 697 2253075 SGTC_2994 9053520 71.4286 µM -0.400706142085986 0.387743346640112 no 2088 0.344318244089343 743 4647384 SGTC_1025 k007-0731 70 µM -0.400763651703061 0.387726628842908 no 2089 0.344297071245173 693 6256118 SGTC_2946 9065502 71.43 µM -0.402467986307404 0.38723128074558 no 2090 0.343669822123846 702 16489101 SGTC_337 1315-0038 354 µM -0.404515830444807 0.386636337825007 no 2091 0.342916719625194 735 1626437 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.407993900703582 0.385626494326132 no 2092 0.341639076394613 689 115019 SGTC_1380 2291-0730 164 µM -0.409188974009224 0.385279688166196 no 2093 0.341200492663733 726 2999191 SGTC_438 sphingosine 6.67 µM -0.411155039967748 0.384709342283102 no 2094 0.340479426683706 712 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_2424 5537928 59.2 µM -0.412676381786734 0.384268179746465 no 2095 0.339921865574441 733 5382802 SGTC_1946 st076057 65.1 µM -0.412984519943448 0.384178843301468 no 2096 0.339808977682888 711 953009 SGTC_1075 aripiprazole 15.2 µM -0.414325811814083 0.383790043216333 no 2097 0.339317756442559 726 60795 An atypical antipschotic. YIL048W NEO1 SGTC_634 1611-4317 11.2 µM -0.415292705319163 0.383509842450124 no 2098 0.338963820326317 729 2843522 SGTC_2234 tolnaftate 200 µM -0.417146435928849 0.382972811300251 no 2099 0.338285650718089 729 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_2976 9009005 19.48 µM -0.417791105914938 0.382786101176837 no 2100 0.338049927125321 739 2993148 SGTC_3208 9114115 49.47 µM -0.419774446250588 0.382211854644569 no 2101 0.33732511711534 751 650895 SGTC_1827 berberine 7.24 µM -0.419996828664437 0.382147483266905 no 2102 0.337243885219524 734 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1878 temozolomide 1 mM -0.422538692092343 0.381411940847437 no 2103 0.336315932570745 740 5394 DNA alkylating agent. SGTC_2957 9076800 11.52 µM -0.422610947687035 0.381391038394695 no 2104 0.33628956891233 746 16459615 SGTC_1667 st014849 34.6 µM -0.424212071449643 0.380927946335074 no 2105 0.335705578982502 729 5348460 SGTC_3071 9117417 49.47 µM -0.424927122327921 0.380721187637443 no 2106 0.335444901100477 726 45595590 YGL055W OLE1 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.425928323272737 0.380431745197983 no 2107 0.335080037873712 725 5379071 SGTC_59 0330-0160 1.33 µM -0.426432725687981 0.38028595019712 no 2108 0.334896279642863 751 4293482 SGTC_846 0335-0850 148 µM -0.426784309696348 0.380184336651047 no 2109 0.334768217872149 721 6819598 SGTC_2565 isoliquiritigenin 100 µM -0.427239486688973 0.380052795316641 no 2110 0.334602451696121 698 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_1945 st075991 56.6 µM -0.427347244433404 0.380021656499242 no 2111 0.334563213241282 723 1084980 SGTC_2667 digitoxin 100 µM -0.428771779593459 0.379610080929049 no 2112 0.33404465893429 717 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2537 larixol 68.93 µM -0.429155206244375 0.37949932487707 no 2113 0.333905139352467 724 6708759 SGTC_2316 5844804 197.44 µM -0.430203914587587 0.379196447073419 no 2114 0.333523657338638 738 776813 SGTC_355 1311-2252 105 µM -0.432567781755166 0.378514009977498 no 2115 0.332664399885622 734 5338538 SGTC_1042 0350-0096 82 µM -0.432601924359011 0.378504155941161 no 2116 0.332651995592611 715 3122515 SGTC_2261 9010538 184.68 µM -0.434618979172259 0.377922145917233 no 2117 0.331919508272419 780 6457250 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.438036519629495 0.376936666318747 no 2118 0.330679905171908 759 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2281 7943571 200 µM -0.439013965245792 0.376654957835769 no 2119 0.330325708653685 742 1244024 SGTC_642 0335-0876 158 µM -0.439795900637492 0.376429644403011 no 2120 0.330042468477586 737 6812350 SGTC_461 N-acetylfarnesylcysteine 136 µM -0.443599357011385 0.375334286225546 no 2121 0.328666135349134 754 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_1692 fluoroquinolonic acid 71 µM -0.443641541726388 0.375322143056411 no 2122 0.328650883208435 755 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_3176 9106582 49.47 µM -0.444048373976784 0.375205039852966 no 2123 0.328503805183587 727 17018027 SGTC_1594 piperine 70.1 µM -0.444991109475492 0.374933725676022 no 2124 0.328163089522565 740 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_3326 9140064 16.379 µM -0.44663716653356 0.374460147779633 no 2125 0.327568527939458 748 1868434 SGTC_958 1222-0007 33 µM -0.448736589461104 0.373856409311191 no 2126 0.326810843237122 758 7312461 SGTC_1986 st071812 45 µM -0.449763063138922 0.373561335158454 no 2127 0.326440646968024 754 11838594 SGTC_2721 ifenprodil 61.44 µM -0.451754602849044 0.37298905085066 no 2128 0.325722888645248 718 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_3184 9108758 49.47 µM -0.452025148160967 0.372911329153472 no 2129 0.325625432856097 749 902885 SGTC_981 1488-1094 54.9 µM -0.452690523121646 0.372720203622403 no 2130 0.325385802302143 723 3449522 SGTC_1079 idarubicin 2.36 µM -0.45300208823006 0.372630718916961 no 2131 0.32527361891612 760 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_82 0054-0107 293.755 µM -0.453911430738638 0.372369585716527 no 2132 0.324946287964553 749 3104697 SGTC_2832 7992762 51.95 µM -0.453930710420786 0.372364049861911 no 2133 0.324939349426477 705 2985177 SGTC_1076 itraconazole 331 nM -0.456566882254826 0.371607363764565 no 2134 0.323991193863383 720 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_261 5-fluorouridine 15.376 µM -0.457930327445753 0.371216195150173 no 2135 0.323501248801432 734 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_892 0929-0076 29 µM -0.458222909979083 0.371132271358263 no 2136 0.323396151020712 704 5751038 SGTC_1303 1160-0052 261 µM -0.458911522625676 0.37093477526657 no 2137 0.323148851948796 754 3562476 SGTC_1998 st075797 76.8 µM -0.459247298881117 0.37083848599459 no 2138 0.323028294120327 752 24208315 SGTC_935 2996-0153 430 µM -0.464007217932929 0.369474374829656 no 2139 0.321321287156697 761 23738523 SGTC_1485 3909-9022 254 µM -0.464438974786769 0.36935072166598 no 2140 0.321166635917724 749 714516 SGTC_1734 st037168 69.4 µM -0.464530732027487 0.369324444557997 no 2141 0.321133773332654 745 708907 SGTC_521 r062-0005 13.8 µM -0.465182435108746 0.369137829750935 no 2142 0.320900408113013 740 2832033 SGTC_711 k292-0785 179 µM -0.465694167929678 0.368991316960408 no 2143 0.320717213745508 747 4146315 SGTC_850 0388-0143 75.9 µM -0.465748571778934 0.368975741865684 no 2144 0.320697740369899 741 67273 SGTC_3239 9133757 49.47 µM -0.468992067610611 0.368047561976577 no 2145 0.319537652995692 760 17036923 SGTC_2072 5231554 129 µM -0.47065393667667 0.367572288609644 no 2146 0.318943941952453 751 789545 SGTC_1504 k297-0033 30 µM -0.4712687860397 0.36739650087348 no 2147 0.3187244015125 706 4388117 SGTC_1227 3909-8010 46.6 µM -0.473000370576292 0.366901583788355 no 2148 0.318106457397173 742 15982272 SGTC_1875 nocodazole 6 µM -0.473449327761638 0.366773300056814 no 2149 0.317946322253134 747 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_322 k048-0136 19.3 µM -0.474235300571815 0.36654875428322 no 2150 0.317666061515229 740 6823282 SGTC_734 2023-0417 80 µM -0.474382800903726 0.366506619775318 no 2151 0.317613477753784 762 3935732 SGTC_2145 5634607 200 µM -0.474491143052047 0.366475672103015 no 2152 0.31757485620012 765 308662 SGTC_316 k060-0003 58.6 µM -0.475330691371993 0.366235886603573 no 2153 0.317275643321924 758 6152314 SGTC_1719 st032227 49.2 µM -0.475798752063578 0.366102225283404 no 2154 0.317108879507273 724 3125804 SGTC_3285 9112818 20.8695 µM -0.476098039150425 0.366016768156446 no 2155 0.317002266950765 761 17017947 YPR165W RHO1 SGTC_743 1275-0778 158 µM -0.47933783259103 0.365092117889681 no 2156 0.315849155969499 747 2849257 YMR203W TOM40 SGTC_449 xestospongin c 11.1929 µM -0.479458098395896 0.365057808594685 no 2157 0.31580638521361 760 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_1901 st060216 58.6 µM -0.480483228411075 0.364765404517764 no 2158 0.315441913027402 736 688792 SGTC_1526 st051518 75 µM -0.482496033302605 0.364191508864908 no 2159 0.314726807801095 745 673993 SGTC_2373 9071805 200 µM -0.484831845215025 0.363525898316407 no 2160 0.31389781562831 779 10149009 SGTC_3174 9107204 49.47 µM -0.486657612332472 0.363005916196515 no 2161 0.313250494240917 769 3938802 SGTC_2243 6634756 200 µM -0.48799250954522 0.362625894504124 no 2162 0.312777573349297 725 885676 SGTC_1508 1080-0625 72.9 µM -0.489942951216452 0.362070881488513 no 2163 0.312087134264842 757 767111 SGTC_2074 5212007 75.395 µM -0.491670226908464 0.361579614034528 no 2164 0.311476244503064 745 758611 SGTC_3046 9092212 49.47 µM -0.492021254157685 0.361479803598629 no 2165 0.311352159207048 739 25236637 SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.492637196767054 0.361304690405274 no 2166 0.311134480269366 735 6708630 An antioxidant. SGTC_2069 5228469 200 µM -0.492782313418101 0.361263437801991 no 2167 0.311083204519732 773 2835210 SGTC_2682 pyrogallin 40.03 µM -0.495490712876774 0.360493812108722 no 2168 0.310126888022119 755 822798 An ATP competetive kinase inhibitor. SGTC_1948 st076329 66.6 µM -0.495842040969502 0.360394019143533 no 2169 0.310002930442367 773 24208413 SGTC_2764 methyldopa 94.69 µM -0.496032273389965 0.360339988556152 no 2170 0.309935820565868 781 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_1126 isoteolin 1.0172 µM -0.497318136282721 0.359974845725962 no 2171 0.309482362150079 737 133323 SGTC_1832 st054113 55 µM -0.497623704590825 0.359888093134227 no 2172 0.309374646363394 759 1251267 SGTC_564 3555-0129 330 µM -0.501975429472427 0.358653398756459 no 2173 0.307842402310251 758 563260 SGTC_2160 5660466 132.927 µM -0.502144813178798 0.358605370073748 no 2174 0.307782829701934 791 2859134 SGTC_685 1278-0033 54.9 µM -0.50278125702767 0.358424926664449 no 2175 0.307559036348023 762 3590572 SGTC_1927 st060202 13.8 µM -0.502968352128086 0.358371887809519 no 2176 0.307493261535469 726 688887 SGTC_2874 9043904 71.43 µM -0.503368737525403 0.358258393307471 no 2177 0.307352523572024 758 4463428 SGTC_1046 2001-0062 216 µM -0.503575159600292 0.358199885149385 no 2178 0.307279976004983 764 739778 SGTC_2569 tetrandrine 100 µM -0.503721152452363 0.358158507026701 no 2179 0.307228670995626 735 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1418 3966-3099 2.4 µM -0.504177405097664 0.358029204053064 no 2180 0.307068358385015 761 740335 SGTC_2591 skatole 100 µM -0.506639786119994 0.35733164145199 no 2181 0.306203793453973 787 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_2227 7312221 64.1025 µM -0.507106940733885 0.357199355932455 no 2182 0.306039892642193 767 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_2308 7584454 197.62 µM -0.508294827481473 0.356863055952544 no 2183 0.305623298488912 770 893577 SGTC_3218 9131285 49.47 µM -0.50969676145542 0.356466300622301 no 2184 0.305131961109461 791 17156417 SGTC_2904 7225135 42.03 µM -0.513522100006311 0.355384498980381 no 2185 0.303793077840332 795 4446116 SGTC_1021 4476-0760 85.3 µM -0.514436537516939 0.35512606911751 no 2186 0.303473409761168 752 746768 SGTC_950 1165-0508 94.1 µM -0.51544177980755 0.354842053725907 no 2187 0.303122171730417 744 6148369 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.515555955290392 0.354809800337592 no 2188 0.303082289594063 759 16725076 SGTC_1292 0kpi-0043 232 µM -0.516522188971982 0.354536891044491 no 2189 0.302744872785212 786 3333905 SGTC_2279 7948423 32.93 µM -0.517238233193377 0.354334695036347 no 2190 0.302494932807068 730 1247112 SGTC_3260 9137109 49.47 µM -0.517339899707672 0.354305989852271 no 2191 0.30245945293802 768 17478346 SGTC_2470 5664817 21.68 µM -0.517800209652313 0.354176033312005 no 2192 0.302298836020593 766 2859561 SGTC_2524 avocatin b 10.57 µM -0.522360006047433 0.352889612850521 no 2193 0.300709848318945 766 6710748 SGTC_2728 chlorpromazine 9.18 µM -0.522470475149729 0.352858467832659 no 2194 0.300671399095885 814 2726 A thorazine and dopamine antagonist. SGTC_1995 st072814 61.1 µM -0.523554703748558 0.35255283906831 no 2195 0.300294146721655 748 5769371 SGTC_1741 st038134 10.228 µM -0.524965429626575 0.352155317800509 no 2196 0.29980361166098 780 1272587 SGTC_1494 4358-1428 177 µM -0.526031825066861 0.351854930805636 no 2197 0.299433047530348 779 1564571 SGTC_991 3996-0057 64.7 µM -0.526220393715079 0.351801823566591 no 2198 0.299367543003899 747 715343 SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.526346503203472 0.351766308529653 no 2199 0.299323739017918 770 75037 A free radical scavenger. SGTC_1072 oxiconazole 14.9 nM -0.527771392026274 0.351365120343561 no 2200 0.298829007657442 753 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_953 1188-0045 9.7 µM -0.52905268309373 0.351004504526701 no 2201 0.298384451995072 766 6144426 SGTC_2011 4012611 177 µM -0.529653195711625 0.350835538065549 no 2202 0.298176202294676 764 2049887 SGTC_113 0099-0221 2.5 µM -0.533629976614122 0.349717335563105 no 2203 0.296798782163203 779 89219 SGTC_2703 st077852 53.4 µM -0.533804883274771 0.349668184646126 no 2204 0.296738267434667 792 6281836 SGTC_3069 9117009 49.47 µM -0.53465016298905 0.349430686204969 no 2205 0.296445894688057 758 41904981 SGTC_787 4152-0075 138 µM -0.535177359606987 0.349282589481385 no 2206 0.296263610186753 752 9566539 SGTC_1450 4112-4260 37.6 µM -0.536035742224249 0.349041507193218 no 2207 0.295966924229272 778 1633175 SGTC_343 4130-2827 29.8 µM -0.536466784047884 0.348920469288797 no 2208 0.295817993115307 756 1118244 SGTC_1026 k007-1105 30.6 µM -0.536599246613136 0.348883276469553 no 2209 0.295772232320904 776 7066794 SGTC_2245 6637752 200 µM -0.537839674164036 0.34853505990991 no 2210 0.295343869544425 752 681890 SGTC_609 0986-0026 86.3 µM -0.538049354312791 0.3484762104657 no 2211 0.295271487911108 763 2848610 SGTC_3273 9137859 49.47 µM -0.538049852031821 0.348476070778759 no 2212 0.295271316108103 795 2377234 SGTC_2924 9010168 62.78 µM -0.538057746814261 0.348473855077572 no 2213 0.2952685909877 760 2993929 SGTC_1183 1254-0324 198 µM -0.539591861461308 0.348043398071147 no 2214 0.29473926523662 763 5799357 SGTC_225 nsc-122657 1.016 µM -0.541815984196068 0.347419679480753 no 2215 0.293972639446034 787 275685 SGTC_1114 scopoletin 1.73284 µM -0.5422562188712 0.347296271817717 no 2216 0.293821005732888 777 5280460 A coumarin with genotoxic properties. SGTC_3274 9138298 49.47 µM -0.54434709908034 0.346710372365429 no 2217 0.293101320887763 776 17015756 SGTC_1241 0364-0022 50.8 µM -0.54454611787968 0.346654623061322 no 2218 0.293032860883169 783 4563895 SGTC_2992 9074591 71.4286 µM -0.545814108844665 0.346299510444116 no 2219 0.292596861969711 789 17741321 SGTC_2116 5511452 16.8835 µM -0.546261626100298 0.346174211323708 no 2220 0.29244305507554 796 870744 SGTC_2144 5628481 200 µM -0.546503046183453 0.346106623771956 no 2221 0.292360097184999 777 2818399 SGTC_448 monastrol 171 µM -0.546859399539767 0.346006868656689 no 2222 0.292237665390434 789 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_2556 citropten 84.59 µM -0.547036424730733 0.345957317410904 no 2223 0.292176853976479 748 2775 A potential DNA crosslinker. SGTC_2774 tamoxifen 10.92 µM -0.548327041176891 0.345596139821034 no 2224 0.291733681502367 786 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.550584160994983 0.344964825225165 no 2225 0.290959384555298 769 6857784 SGTC_783 0848-0141 92.7 µM -0.5514904255639 0.344711465015671 no 2226 0.290648764128003 774 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_2690 usnic acid 100 µM -0.551851820330688 0.344610450959962 no 2227 0.290524940048236 801 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2961 9083290 32.55 µM -0.552636960002412 0.344391033446072 no 2228 0.290256014076579 789 17741490 SGTC_2964 9083345 53.42 µM -0.5537884791712 0.344069321130157 no 2229 0.289861806885083 771 17741579 SGTC_405 ebelactone b 50 µM -0.554294170835667 0.343928076243546 no 2230 0.289688769496643 773 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_3317 9138495 8.753 µM -0.554483137345027 0.343875301540819 no 2231 0.289624121450928 799 17020139 SGTC_1216 1165-0504 9.65 µM -0.554492539659401 0.343872675735124 no 2232 0.289620904966552 785 6304004 SGTC_1893 st059353 36.1 µM -0.554615792496107 0.343838255331852 no 2233 0.289578742342892 826 3112488 SGTC_2978 9011784 42.97 µM -0.555227665943588 0.343667398668235 no 2234 0.289369473894637 753 2994934 SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.556308102173982 0.343365780723312 no 2235 0.28900012466498 806 229346 A bile salt which induces apoptosis. SGTC_1928 4'-methoxychalcone 40.3 µM -0.557293191600166 0.34309086699692 no 2236 0.288663563337422 787 641818 SGTC_1763 st044482 94.5 µM -0.558168937633721 0.342846537978147 no 2237 0.288364514885319 795 88505 SGTC_1805 st050013 60.3 µM -0.559659567749067 0.342430810356412 no 2238 0.287855832900038 785 4037144 SGTC_898 1000-0849 28.3 µM -0.559873201844672 0.342371244737223 no 2239 0.28778296436114 798 6751807 SGTC_3196 9111891 49.47 µM -0.559999426961548 0.342336052397795 no 2240 0.287739914281409 804 18891510 SGTC_1294 1000-1494 117 µM -0.561039688016236 0.342046073370873 no 2241 0.2873852408965 754 712797 YDL207W GLE1 SGTC_1614 st002383 48.6 µM -0.562430787816395 0.341658441505074 no 2242 0.28691127370206 766 1947235 SGTC_3280 9140961 49.47 µM -0.564249816979283 0.341151818412433 no 2243 0.286292064344011 802 4901226 SGTC_811 0416-0114 265 µM -0.564406599581072 0.341108165820043 no 2244 0.286238724241182 791 6612453 SGTC_2770 toltrazuril 17.5 µM -0.566278774192081 0.340587065328946 no 2245 0.285602143591254 778 68591 Kills coccidiodes. SGTC_1116 jasmonic acid  1.58368 µM -0.568646034240243 0.339928598397141 no 2246 0.284798188841737 809 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_815 1582-0027 36.9 µM -0.571070784895359 0.339254646040858 no 2247 0.283975830718392 793 3128206 SGTC_1512 0259-0544 12.2 µM -0.572268398977988 0.338921962170046 no 2248 0.283570077573381 774 18476 SGTC_592 k241-0073 46.5 µM -0.572711376704677 0.338798939689409 no 2249 0.28342006657471 796 4230158 SGTC_1674 st016616 23.6 µM -0.572921353071675 0.338740631671662 no 2250 0.283348972986141 785 625830 SGTC_2670 beta-carotene 100 µM -0.574576935898939 0.33828103084509 no 2251 0.2827887271183 758 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_3111 9122088 49.47 µM -0.575673770187043 0.337976674928366 no 2252 0.282417853913891 779 16876704 SGTC_169 k015-0017 16.025 µM -0.575811514563837 0.337938460302342 no 2253 0.282371294868683 841 1840002 SGTC_655 k060-0012 42 µM -0.57602147845721 0.337880212922481 no 2254 0.282300331973335 797 5994525 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.576301710440739 0.33780247808613 no 2255 0.282205633474725 801 5355888 SGTC_144 4161-2749 112.381 µM -0.576582312316614 0.337724647575191 no 2256 0.282110825301477 788 797501 YMR168C CEP3 SGTC_1697 st025554 27.742 µM -0.576976915985502 0.337615208140787 no 2257 0.281977524799613 788 1269519 SGTC_1691 st019933 84.6 µM -0.578281408227803 0.337253517856176 no 2258 0.281537072191604 796 6176082 SGTC_1591 genipin 88.4 µM -0.580701077497045 0.336583026107689 no 2259 0.280720967701228 822 442424 A DNA cross-linking agent. SGTC_791 1348-1292 225 µM -0.581637784558087 0.336323603326325 no 2260 0.280405343241839 798 5437054 SGTC_739 1486-1183 203 µM -0.581941007907322 0.336239641736558 no 2261 0.280303208629336 781 4346692 SGTC_2459 5811157 9.22 µM -0.584530812682823 0.335522866113878 no 2262 0.279431620490515 792 2870684 YBR192W RIM2 SGTC_2141 5621638 7.665 µM -0.586517284021892 0.334973479197063 no 2263 0.278763975019629 797 2856238 SGTC_1145 3546-0597 10.2 µM -0.588657337093208 0.334382011975513 no 2264 0.278045581263582 792 875334 SGTC_3192 9110362 49.47 µM -0.58884665837063 0.334329707180236 no 2265 0.277982071575605 808 16649480 SGTC_1675 st018485 24.5 µM -0.589345962536705 0.334191777194238 no 2266 0.277814609034707 805 3323024 SGTC_108 0509-0257 621.132 µM -0.589425902575232 0.334169696283894 no 2267 0.277787802373394 786 536624 SGTC_428 3448-4153 16.5 µM -0.592225455998674 0.333396770550693 no 2268 0.276849812686287 760 3834874 SGTC_315 k915-0449 187 µM -0.595071031475484 0.332611862897885 no 2269 0.275897995740631 793 20970215 YNL149C PGA2 SGTC_2219 9098279 200 µM -0.595085030566048 0.33260800327668 no 2270 0.275893317159424 784 902349 SGTC_450 aminopyrene 156 nM -0.595848426046177 0.332397558095929 no 2271 0.275638244776764 807 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_567 1080-0542 68.4 µM -0.595854663318519 0.332395838884958 no 2272 0.275636161202329 761 5950415 SGTC_1031 k035-0009 16 µM -0.596439854826381 0.332234555274984 no 2273 0.27544071115432 806 5180959 SGTC_2077 5212015 200 µM -0.59990290107158 0.331280747896897 no 2274 0.274285474444418 794 780900 SGTC_3108 9121785 49.47 µM -0.600878456945527 0.331012253160675 no 2275 0.273960471450814 787 17140271 SGTC_3137 9097352 49.47 µM -0.602353730953773 0.33060638991675 no 2276 0.273469350974728 845 44120435 SGTC_256 clotrimazole 625 nM -0.602736120641384 0.330501223004715 no 2277 0.273342124154137 771 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_590 k048-0076 22.4 µM -0.603173249312879 0.330381017870802 no 2278 0.273196720764082 813 6832814 SGTC_2462 5162487 171.77 µM -0.604283754157735 0.33007572110017 no 2279 0.272827502715039 794 2259986 SGTC_1295 1013-0063 9.78 µM -0.60464993012354 0.329975077855621 no 2280 0.272705811674217 795 6826038 SGTC_2259 7964009 200 µM -0.605872877510908 0.32963904070812 no 2281 0.272299585591227 788 313134 SGTC_1638 st008370 60.6 µM -0.606367630526923 0.329503133276022 no 2282 0.272135329086418 790 24207134 SGTC_11 0438-0307 1.3 µM -0.606659203390321 0.329423049474414 no 2283 0.272038550850172 808 4011476 SGTC_1439 4092-1168 46 µM -0.608397730521656 0.328945705738789 no 2284 0.271461858159717 813 2886240 SGTC_440 fluspirilene 35.1 µM -0.608511077097556 0.328914594082213 no 2285 0.271424280742878 807 3396 An atypical antipsychotic. SGTC_1209 2323-2347 50.3 µM -0.612511967698894 0.327817180140036 no 2286 0.270099541190854 794 5412760 SGTC_702 1488-0190 94 µM -0.61294153366894 0.327699441586683 no 2287 0.269957499621962 793 949357 SGTC_1690 st023502 41.2 µM -0.6141845043814 0.327358855689015 no 2288 0.269546705911797 811 24207482 SGTC_486 niguldipine 82 µM -0.614275640996945 0.327333889031748 no 2289 0.269516598185515 800 1236 A calcium channel blocker. SGTC_250 brefeldin a 552.239 µM -0.614830540749585 0.327181892246738 no 2290 0.269333318892704 797 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_1142 3253-1408 9.78 µM -0.617110776193853 0.326557596766938 no 2291 0.268580830638141 810 256655 SGTC_2161 5662504 8.5105 µM -0.617782736430643 0.326373716297734 no 2292 0.268359282393608 798 2859334 SGTC_1898 st060199 18.6 µM -0.619279213939751 0.325964360107352 no 2293 0.267866217683263 792 688866 SGTC_3327 9140648 26.9345 µM -0.62020368717274 0.325711578426503 no 2294 0.267561847152762 815 8029710 SGTC_3348 9149464 3.537 µM -0.624279382301186 0.324598104514225 no 2295 0.266222060891553 796 1951442 SGTC_2751 anetholtrithion 17.25 µM -0.624406348816354 0.324563442550012 no 2296 0.266180378330086 808 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_1534 6-azauridine 81.6 µM -0.624511611572282 0.324534706882229 no 2297 0.266145823524918 801 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_1181 1222-0449 220 µM -0.628216591417973 0.323523951345006 no 2298 0.264931031432996 817 658318 SGTC_2157 5649910 96.377 µM -0.628629158581892 0.323411479249918 no 2299 0.264795933111364 809 2858091 SGTC_776 4476-4378 112 µM -0.629532741209714 0.323165205232788 no 2300 0.264500170369732 837 2892008 SGTC_2580 diallyl disulphide 81.36 µM -0.62990966638074 0.323062496101136 no 2301 0.264376844062326 806 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_1214 0358-0031 63.7 µM -0.631010007819398 0.322762738942509 no 2302 0.264016990404522 827 4301366 SGTC_2185 6113692 200 µM -0.631642141995639 0.322590583772914 no 2303 0.263810371340772 822 874150 SGTC_1125 tnp00248 1.32998 µM -0.633296996156624 0.322140081603297 no 2304 0.26326985726217 809 24207736 SGTC_2134 5324836 1.464 µM -0.633625433029946 0.322050702032668 no 2305 0.263162649402698 830 699272 SGTC_1996 st072960 66.8 µM -0.636567230387437 0.321250591839077 no 2306 0.262203388019337 795 1719405 SGTC_974 1326-0144 138 µM -0.636657222650482 0.321226128787323 no 2307 0.262174071604175 819 5411856 SGTC_939 1165-0479 45.3 µM -0.637128175370275 0.32109811998227 no 2308 0.262020678641436 816 1377347 SGTC_1958 st076513 41.9 µM -0.637585183250013 0.3209739218201 no 2309 0.261871871617321 817 732122 YGL099W LSG1 SGTC_460 trequinsin 123 µM -0.645193570825701 0.318909189239003 no 2310 0.25940087601401 834 5537 A vasodilator. SGTC_1056 3448-1962 115 µM -0.645657276937004 0.318783531264125 no 2311 0.259250667346606 810 715507 SGTC_3201 9113999 49.47 µM -0.654402011687476 0.316417742482236 no 2312 0.256426419347787 817 16649224 SGTC_985 1493-0307 8.71 µM -0.656167885694239 0.315940911542515 no 2313 0.255858054673196 826 3278274 SGTC_1277 0873-0036 22 µM -0.656979248878407 0.315721925400379 no 2314 0.255597129727109 819 5965735 SGTC_3182 9108849 49.47 µM -0.657403218170145 0.31560752221953 no 2315 0.255460841449415 804 17133045 SGTC_757 1066-0008 322 µM -0.658393050049554 0.315340496395213 no 2316 0.255142800045232 797 6842497 SGTC_1333 1482-0047 286 µM -0.66030988756504 0.314823667567952 no 2317 0.254527493137548 827 3811116 SGTC_188 3229-0966 278.469 µM -0.660814370141845 0.314687706265821 no 2318 0.254365683009071 821 5722370 SGTC_1810 st050138 53 µM -0.661453432955959 0.314515510790085 no 2319 0.254160784415853 850 3444541 SGTC_615 k087-0205 167 µM -0.663714344363314 0.313906632236528 no 2320 0.253436578380499 829 9642773 SGTC_1330 1469-0054 61.8 µM -0.664419621815635 0.313716799840054 no 2321 0.253210888860149 822 7102664 SGTC_2973 9094665 17.96 µM -0.666143459901154 0.313253019411442 no 2322 0.252659704049536 833 25237061 YIL048W NEO1 SGTC_2930 9013230 14.89 µM -0.666783706632462 0.313080842933126 no 2323 0.252455150821968 809 2995857 SGTC_1571 st070080 73.4 µM -0.666968625121777 0.313031121852473 no 2324 0.252396087230475 823 4315245 SGTC_1703 st026983 48.3 µM -0.667070749103942 0.313003664104504 no 2325 0.252363471606988 818 1104023 SGTC_2523 spermine 47.74 µM -0.667107199067457 0.312993864170702 no 2326 0.252351831017614 793 1103 A DNA binding polyamine. SGTC_2526 patulin 37.61 µM -0.672906654991713 0.311436309698067 no 2327 0.250503339038319 822 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_2216 7189485 200 µM -0.674966657654827 0.310883866079096 no 2328 0.249848474359888 808 731273 SGTC_2429 5902844 64.44 µM -0.675517999496632 0.310736081547504 no 2329 0.24967335980168 834 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_1847 st056231 15 µM -0.676921568811551 0.310359999369195 no 2330 0.249227859196305 817 5393180 SGTC_1521 st012942 49.4 µM -0.677142623659676 0.310300786442715 no 2331 0.24915773372475 805 24207259 SGTC_2661 dactinomycin 12.96 µM -0.677241280408248 0.310274361308535 no 2332 0.249126440123742 822 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_2777 climbazole 1.536 µM -0.677523589200859 0.310198750527681 no 2333 0.24903690424143 830 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_1656 st012921 11 µM -0.681901963373843 0.309027119047181 no 2334 0.247650471923204 820 6732821 SGTC_868 0527-0199 213 µM -0.683018699998243 0.308728595846099 no 2335 0.247297513111367 825 2849450 SGTC_2529 gangaleoidin 93.61 µM -0.683488394467117 0.308603076045966 no 2336 0.24714914058607 842 4565183 SGTC_1132 3456-3614 2.5 µM -0.685774892942078 0.307992358366907 no 2337 0.246427535524276 830 3125502 SGTC_1258 0671-0043 57.1 µM -0.685893707540449 0.307960637811997 no 2338 0.246390069241442 838 4298767 SGTC_2727 riluzole 51.77 µM -0.686025014963839 0.307925583651251 no 2339 0.246348667097683 841 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_909 3448-9333 149 µM -0.686130015057634 0.307897553822614 no 2340 0.246315562521315 841 3344074 SGTC_714 4296-0578 26.1 µM -0.686350581084508 0.307838677259462 no 2341 0.246246029922935 837 1589775 SGTC_1792 st045773 43.6 µM -0.687268855710176 0.307593611761883 no 2342 0.245956660498809 788 2919270 SGTC_1304 1165-0502 251 µM -0.687495415838814 0.307533161489392 no 2343 0.245885294271992 829 767425 SGTC_3115 9123671 49.47 µM -0.689736923103754 0.30693536933497 no 2344 0.245179820885989 842 3286988 SGTC_1642 st009582 77.7 µM -0.690032665896808 0.306856535354994 no 2345 0.245086822598002 849 6739311 SGTC_3329 9141233 27.5565 µM -0.690774412510192 0.30665885271521 no 2346 0.244853658934657 835 4909101 YNL103W MET4 SGTC_2491 paeonol 100 µM -0.691765383430027 0.306394837136342 no 2347 0.244542339471044 833 11092 Increases levels of cortical cytochrome oxidase. SGTC_3080 9117754 49.47 µM -0.692938874579666 0.306082324253835 no 2348 0.244173956096309 838 9550191 SGTC_2452 5863136 48.41 µM -0.693404168797033 0.305958450617482 no 2349 0.244027973412023 830 2184096 SGTC_936 3005-4620 401 µM -0.693745063026571 0.305867709634108 no 2350 0.24392105020962 835 777207 SGTC_1401 3807-4679 7.6 µM -0.694068283444524 0.305781684161719 no 2351 0.243819693839058 842 3291456 SGTC_1169 aniline yellow 25.8 µM -0.694570655337365 0.305647998598104 no 2352 0.243662203775718 834 6051 A DNA damaging agent. SGTC_3213 9129884 49.47 µM -0.695482336102172 0.305405458518723 no 2353 0.243376538596144 829 17190742 SGTC_324 1315-0088 19.6 µM -0.6977978203937 0.30478983992171 no 2354 0.242651821189919 848 6787421 SGTC_2704 st078022 71.1 µM -0.698696782778336 0.304550981218682 no 2355 0.242370772481267 839 54697681 SGTC_1177 0983-0204 23.6 µM -0.701434172162607 0.30382415692716 no 2356 0.241516051193175 831 766818 SGTC_1269 0831-0796 3.05 µM -0.702253216428656 0.303606836986659 no 2357 0.241260631691441 829 927758 SGTC_678 1218-2179 85.9 µM -0.702702511461664 0.303487653416103 no 2358 0.241120581110622 860 6820081 YOR116C RPO31 SGTC_2276 7947513 42.08 µM -0.707623783578323 0.302183568257082 no 2359 0.239589459593608 837 2105100 SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.7113234353747 0.301204858933051 no 2360 0.238441916188069 849 94937 An inhibitor of serotonin biosynthesis. SGTC_1906 st060206 94.7 µM -0.712027432651256 0.30101878466561 no 2361 0.238223894404475 849 5133468 SGTC_1457 k015-0032 57.3 µM -0.71327278728667 0.300689750634677 no 2362 0.237838486617215 846 4302660 SGTC_2843 9000894 45.46 µM -0.714726721305392 0.300305813549511 no 2363 0.237388961434145 776 2242070 SGTC_551 k048-0028 34.9 µM -0.717792914100036 0.299496858167077 no 2364 0.236442491550255 849 6836383 SGTC_1896 st058441 89 µM -0.718789136163324 0.299234237106201 no 2365 0.236135426186485 832 688759 SGTC_1391 3442-0225 151 µM -0.71969816508103 0.298994692851938 no 2366 0.235855428135599 835 5227075 SGTC_570 0987-0065 62.6 µM -0.719831473189554 0.298959571268982 no 2367 0.235814382117766 821 3104428 SGTC_459 nigericin 15.3 µM -0.720417318748896 0.298805245609623 no 2368 0.235634044979155 857 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_1440 4100-1550 40 µM -0.721780218488667 0.298446365544925 no 2369 0.235214806641528 846 742806 SGTC_532 1548-0774 215 µM -0.723178721763984 0.298078314347514 no 2370 0.234785044889484 865 5932993 SGTC_1466 k213-0079 57.5 µM -0.724964489332881 0.297608645729019 no 2371 0.234236907935926 869 3657981 SGTC_331 k048-0133 24.5 µM -0.725017891970679 0.29759460568673 no 2372 0.234220527044555 835 6813582 SGTC_2767 sibutramine 71.45 µM -0.725362287439205 0.297504068228324 no 2373 0.234114901341032 838 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_211 3455-0679 143.504 µM -0.726436167452535 0.297221838770176 no 2374 0.233785712968022 818 748649 SGTC_912 3474-0017 2.18 µM -0.727108418550709 0.297045224851765 no 2375 0.233579771003453 850 3360550 SGTC_1963 st076565 50.3 µM -0.729352439776455 0.296456023041525 no 2376 0.232893051226807 880 4914280 SGTC_244 nsc-207895 1.295 µM -0.729681763709523 0.296369599138705 no 2377 0.232792365330924 813 42640 SGTC_2154 5570129 200 µM -0.730034115475882 0.296277144874352 no 2378 0.232684665806196 876 673366 SGTC_687 k029-0044 34.9 µM -0.731051134252921 0.296010361557999 no 2379 0.232373960143336 827 5829338 SGTC_1406 3909-7906 11.9 µM -0.73343720925956 0.295384882089361 no 2380 0.231645905844638 844 X1406 SGTC_1820 st053765 18.6 µM -0.733647679902405 0.295329739060013 no 2381 0.2315817467799 838 3690829 SGTC_1879 gemcitabine 100 µM -0.736009282516272 0.294711327343586 no 2382 0.230862524362401 874 60750 A nucleoside analog which inhibits DNA replication. SGTC_2634 4'-methoxyflavone 100 µM -0.737243018820284 0.294388497531545 no 2383 0.230487288466308 841 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_523 1934-0222 13.7 µM -0.738160375960226 0.294148560037749 no 2384 0.230208499133889 867 1361595 SGTC_142 0335-0849 62.6745 µM -0.738673606402864 0.294014362518409 no 2385 0.230052608205518 832 3889043 YPR107C YTH1 SGTC_1711 st032263 62.8 µM -0.738757693144933 0.293992378539804 no 2386 0.230027072952448 857 3958979 SGTC_3227 9130768 49.47 µM -0.739754821046477 0.293731743341301 no 2387 0.22972438857945 861 17720899 SGTC_3299 9121982 43.1275 µM -0.740276413451595 0.293595449038134 no 2388 0.229566144862875 839 17594604 YPL160W CDC60 SGTC_1825 st052143 62.6 µM -0.740804988499839 0.293457360019297 no 2389 0.229405845033658 854 674173 SGTC_1352 1496-0991 99 µM -0.742169968048238 0.293100901476501 no 2390 0.228992180923551 852 3000039 SGTC_2722 naftopidil 47.16 µM -0.743199675381263 0.292832130790527 no 2391 0.228680399937686 862 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_3004 9076122 71.4286 µM -0.745100994772457 0.292336155817509 no 2392 0.228105333901606 858 44782551 SGTC_1704 st028805 70.8 µM -0.745488533469291 0.292235111073522 no 2393 0.227988220228528 856 2876101 SGTC_1997 st073024 93.8 µM -0.745755088151834 0.29216562047946 no 2394 0.227907687398039 851 686268 SGTC_390 dec-rvkr-cmk 16.7 µM -0.745937673649673 0.292118025022876 no 2395 0.227852532993962 850 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_1354 1498-1681 81 µM -0.746945657448412 0.291855333917488 no 2396 0.227548182114724 854 5754243 SGTC_937 3122-0005 46.7 µM -0.747403993549881 0.291735923147456 no 2397 0.227409867748023 841 759535 SGTC_1575 cyproterone acetate 48 µM -0.7480017339088 0.29158022746184 no 2398 0.227229555844032 870 9880 An androgen receptor antagonist and liver toxin. SGTC_1498 4478-3555 97.6 µM -0.748285713409586 0.29150627182845 no 2399 0.227143919993943 841 3437919 SGTC_1316 1272-0050 65.9 µM -0.748640400713558 0.291413914336731 no 2400 0.227036987305341 858 7340392 SGTC_1045 1348-1485 165 µM -0.749066267239839 0.291303040433475 no 2401 0.226908632700466 845 6810614 SGTC_1002 4049-0206 172 µM -0.750639860257477 0.290893528017801 no 2402 0.226434712742255 853 4662749 SGTC_1387 3342-1166 1.8 µM -0.753118971665441 0.290248909603434 no 2403 0.225689212470209 840 3418228 SGTC_1349 flufenamic acid 69 µM -0.753186671870493 0.290231315589549 no 2404 0.22566887365603 859 3371 A non-steroidal anti-inflammatory. SGTC_1328 1441-0025 69.2 µM -0.753624649859053 0.29011750539538 no 2405 0.225537319306175 859 4562601 SGTC_2222 6885208 172.143 µM -0.756919937948291 0.289261884051428 no 2406 0.224548914804289 849 609514 SGTC_96 0929-0093 37.281 µM -0.757992407858622 0.288983673346993 no 2407 0.224227763901695 872 6991579 SGTC_1822 st052468 42 µM -0.7588483806136 0.288761714803328 no 2408 0.223971630283608 860 2873678 SGTC_2568 diosmetin 100 µM -0.762229748033733 0.287885692990235 no 2409 0.222961447163331 863 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_602 3130-1533 38.1 µM -0.763884952746134 0.287457331763227 no 2410 0.22246790261125 862 720941 SGTC_2414 st077232 92.9 µM -0.766385535176278 0.286810761999595 no 2411 0.221723468502789 840 729801 SGTC_2430 5571206 200 µM -0.766799477617587 0.286703796400871 no 2412 0.221600373509321 857 1731771 SGTC_997 3996-0078 137 µM -0.767622728928228 0.28649111878395 no 2413 0.221355677532272 850 735687 SGTC_2386 9075165 157.42 µM -0.770557554968864 0.285733549555889 no 2414 0.220484613964397 852 16452277 SGTC_1160 4092-0570 10.5 µM -0.771010345923482 0.285616755132487 no 2415 0.220350399625731 867 4994975 SGTC_2280 7785178 200 µM -0.772779361436732 0.28516066721356 no 2416 0.219826484841727 856 2954328 SGTC_2339 9000433 200 µM -0.773819461582478 0.284892670534735 no 2417 0.219518781008404 859 2988954 SGTC_1985 st071382 65.5 µM -0.774745905208009 0.284654060302087 no 2418 0.219244909838566 881 6123237 SGTC_1798 st045719 60.953 µM -0.774937981925585 0.284604601917467 no 2419 0.219188153558605 846 3980186 SGTC_1815 st051655 58.2 µM -0.775222839243168 0.284531260746098 no 2420 0.219103997319642 862 5984156 SGTC_1809 st050081 57.6 µM -0.775716683663688 0.284404133823803 no 2421 0.218958143437015 866 5036894 SGTC_277 nystatin 15.5 µM -0.777623171470198 0.283913614764679 no 2422 0.218395598340728 878 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1764 st044502 93.5 µM -0.780404131146187 0.283198830293295 no 2423 0.217576518503911 865 8407 SGTC_1146 3579-1023 7 µM -0.781230828469351 0.282986512527369 no 2424 0.217333372495254 883 X1146 SGTC_1194 1488-0194 225 µM -0.78169007739375 0.282868598267338 no 2425 0.21719836725078 864 1391452 SGTC_2850 9015429 58.44 µM -0.783263363159133 0.282464828934371 no 2426 0.216736236401973 887 6457570 SGTC_539 4859-0462 2.54 µM -0.783444680413237 0.282418313345183 no 2427 0.216683013542863 856 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_792 4534-1957 155 µM -0.786861100995204 0.281542545563687 no 2428 0.215681590392232 860 1717904 SGTC_409 arachidonic acid 100 µM -0.787112256701534 0.281478215849525 no 2429 0.215608077518757 867 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_1862 st057513 3.81 µM -0.787388369909465 0.281407501835606 no 2430 0.215527276393412 876 5393163 SGTC_338 4055-0136 114 µM -0.787749388722444 0.281315055993786 no 2431 0.215421655187424 869 2900563 SGTC_1259 0671-0132 43 µM -0.788081571242859 0.28123000719427 no 2432 0.215324496981248 865 X1259 SGTC_2588 indole-3-carbinol 100 µM -0.789399069591619 0.28089280998692 no 2433 0.21493939976196 866 3712 Induces cell cycle arrest. SGTC_2626 ethyl orsellinate 100 µM -0.790988586747117 0.280486253281294 no 2434 0.214475325838414 882 75653 A natural product. SGTC_2837 9008476 45.46 µM -0.79154457871415 0.280344112419543 no 2435 0.214313136581507 859 2992805 SGTC_2355 9061122 103.12 µM -0.791651232276664 0.280316850133554 no 2436 0.214282032666592 884 5302957 SGTC_2858 9025781 8.96 µM -0.792430270107536 0.280117755068982 no 2437 0.214054917600152 849 4894980 YPL153C RAD53 SGTC_2312 7706453 155.7 µM -0.793925926156405 0.279735709416711 no 2438 0.213619277735817 874 976098 SGTC_3237 9133362 49.47 µM -0.794646253506068 0.279551801524389 no 2439 0.213409652357775 867 43845137 SGTC_1790 st045711 43.5 µM -0.794732206094089 0.279529860756685 no 2440 0.213384646957242 827 585119 SGTC_686 1319-0111 510 µM -0.794875926241862 0.279493175766842 no 2441 0.21334283958451 911 4562600 SGTC_230 MPP+ 141.667 µM -0.795277245133317 0.279390750321681 no 2442 0.213226123491837 871 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_2730 imipramine 71.33 µM -0.796580281385741 0.279058312457363 no 2443 0.212847416596829 861 3696 A tricyclic antidepressant. SGTC_2464 5717415 7.67 µM -0.80005724335834 0.278172193141025 no 2444 0.211838816045742 873 5285744 SGTC_1519 esterone 74 µM -0.803268787394208 0.27735493776914 no 2445 0.210909697230341 871 698 A steroid. SGTC_2200 6600604 21.907 µM -0.803674149833663 0.277251866957944 no 2446 0.210792593533146 912 2904777 SGTC_3085 9117376 49.47 µM -0.806044234544511 0.276649604871014 no 2447 0.210108671994679 867 16480349 SGTC_2696 st077691 74.316 µM -0.806078590186998 0.276640879477122 no 2448 0.210098767781539 887 757133 SGTC_1310 1188-0297 994 nM -0.80617547082159 0.276616275171124 no 2449 0.210070840034239 850 1588352 SGTC_29 0299-0004 12.984 µM -0.808282435261592 0.276081445071976 no 2450 0.209464005809661 865 16871 A napthoquinone isolated from Swertia calycina. SGTC_2786 7743617 45.45 µM -0.81016253588212 0.275604630930155 no 2451 0.208923383189139 870 583674 SGTC_3002 9075603 71.4286 µM -0.810854298531357 0.275429294291609 no 2452 0.208724673995561 874 20105405 SGTC_2014 4013930 200 µM -0.811401691998385 0.275290588888624 no 2453 0.208567513898519 879 64556 SGTC_1122 capsaicin 818.572 nM -0.813549749032303 0.274746619734345 no 2454 0.207951467667781 873 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_2457 5731572 11.68 µM -0.815399493092058 0.274278619756508 no 2455 0.207421837203028 870 2865357 SGTC_2905 7799065 20.05 µM -0.816106577579771 0.274099825802172 no 2456 0.20721959113533 858 1296806 SGTC_1225 1216-0074 20.6 µM -0.817358916783633 0.273783299675691 no 2457 0.20686167321065 879 4241466 SGTC_2416 tofa 880 nM -0.821695066023171 0.272688745462759 no 2458 0.205625233996736 875 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1793 st048256 72.231 µM -0.824637538706009 0.271947229431247 no 2459 0.204788701368567 856 672022 SGTC_1856 st057054 55.7 µM -0.825210061130774 0.271803067912215 no 2460 0.204626171185065 877 1266018 SGTC_2938 9059746 27.26 µM -0.82860998061944 0.270947750241636 no 2461 0.203662569274285 901 6471769 SGTC_2966 9084041 48.03 µM -0.82982614532295 0.270642126147119 no 2462 0.203318543131868 880 17741380 SGTC_968 1309-0633 340 µM -0.831149808837353 0.270309683219037 no 2463 0.202944502338328 886 3761976 SGTC_1770 st043884 66.3 µM -0.831463282480274 0.270230983077587 no 2464 0.202855981192266 910 670149 SGTC_2934 9036370 36.88 µM -0.832627631831536 0.269938763932833 no 2465 0.202527385090874 857 6462800 SGTC_284 0988-0104 32.6 µM -0.833051086029561 0.269832527997271 no 2466 0.202407959187597 895 4666532 SGTC_1747 st037496 66.6 µM -0.833864400738522 0.269628542820811 no 2467 0.202178699886099 896 723305 SGTC_382 3229-0966 23.2 µM -0.834454183450839 0.269480669415571 no 2468 0.20201254759485 888 5722370 SGTC_2884 9058502 51.95 µM -0.834466219706748 0.269477652045847 no 2469 0.202009157618403 869 6471554 SGTC_2881 9058953 51.95 µM -0.836344369243058 0.269007026206441 no 2470 0.201480599535196 851 17122249 SGTC_1064 honokiol 6.76 µM -0.840108357563287 0.268065091336798 no 2471 0.200423817270722 887 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_2388 9080168 200 µM -0.840802803904727 0.267891488325245 no 2472 0.200229208047122 889 15943073 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.842089082318945 0.267570084249617 no 2473 0.199869045954742 870 6708739 YPR165W RHO1 SGTC_3010 9080089 71.4286 µM -0.843151566207716 0.267304746696712 no 2474 0.199571841088928 874 17027233 SGTC_1725 st036284 20.55 µM -0.844614435790478 0.26693963688625 no 2475 0.199163073221023 877 707914 SGTC_650 1328-0195 38 µM -0.84472802198878 0.266911298055998 no 2476 0.199131355081902 886 2780821 SGTC_1220 1838-0075 193 µM -0.845235865963219 0.26678461371604 no 2477 0.198989580480222 869 5529645 SGTC_251 melphalan 456.522 µM -0.845739847498014 0.266658922929554 no 2478 0.198848944305299 883 460612 A DNA alkylator. SGTC_2478 5763493 32.33 µM -0.845901669687881 0.266618571534863 no 2479 0.198803800492781 868 1365576 YLR208W SEC13 SGTC_373 0844-0104 25.9 µM -0.846206535553356 0.266542559675712 no 2480 0.198718768328522 874 5375804 SGTC_3101 9120531 49.47 µM -0.84688749294747 0.266372816932012 no 2481 0.19852891719104 895 24824904 SGTC_1087 pterostilbene 9.05 µM -0.847846582522127 0.266133836782692 no 2482 0.198261708362404 898 5281727 Similar to reservatol, lowers cholesterol. SGTC_2422 chlorphenesin carbamate 384.24 µM -0.848248058222244 0.266033831736122 no 2483 0.198149919007024 883 2724 A muscle relaxant with antifungal properties. SGTC_2444 5485484 36.41 µM -0.85180214049104 0.265149363295192 no 2484 0.197161959074627 917 6790631 SGTC_819 1013-0258 27.7 µM -0.852217451895054 0.26504610649037 no 2485 0.197046706072728 894 5753198 SGTC_3068 9116768 49.47 µM -0.853235493023119 0.264793082437786 no 2486 0.196764362172094 883 41904888 SGTC_731 3966-0296 387 µM -0.853634265528733 0.264694004959229 no 2487 0.19665383327363 871 660956 SGTC_275 trichlorophene 5.69 µM -0.853687063042359 0.264680888506113 no 2488 0.19663920205803 870 62616 SGTC_1715 st032160 10.2275 µM -0.853729692222071 0.264670298406997 no 2489 0.196627389166257 866 5289825 SGTC_2627 acetyl isogambogic acid 100 µM -0.861118266983418 0.262838062630808 no 2490 0.194586454689242 910 6857789 A caspase activator and apoptosis inducer. SGTC_1065 prochlorperazine maleate 2.48 µM -0.863065074401948 0.262356370823139 no 2491 0.194050844578804 897 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_2822 7994718 71.43 µM -0.865127209258609 0.261846637449659 no 2492 0.193484485997155 929 1018011 SGTC_362 0310-0100 9.03 µM -0.865167219818485 0.261836752376453 no 2493 0.19347350720933 886 790235 SGTC_2872 9044037 25.97 µM -0.865806727554091 0.261678780550591 no 2494 0.193298079625678 892 6465195 SGTC_32 0928-0142 34.1 µM -0.86619730925997 0.261582322738033 no 2495 0.193190984346413 882 2244242 SGTC_1254 0550-0035 264 µM -0.866205108302748 0.261580396877194 no 2496 0.19318884626219 912 15121435 SGTC_2284 7945075 39.21 µM -0.867015622137879 0.261380291893521 no 2497 0.192966725077852 895 1245402 SGTC_2807 7945238 51.95 µM -0.867936508837837 0.261153032777374 no 2498 0.192714545585265 902 17148797 SGTC_1555 citronellol 128 µM -0.86829420525392 0.261064786799592 no 2499 0.192616646818185 883 8842 A terpine precursor. SGTC_733 4069-0007 56.1 µM -0.872173253622714 0.260108786403358 no 2500 0.191556934153328 905 5717425 YNL287W SEC21 SGTC_109 0132-0036 33.701 µM -0.877555548746414 0.258785303065834 no 2501 0.190092480544711 853 67274 A color developer. SGTC_2390 9097792 176.6 µM -0.878846284514679 0.25846843554257 no 2502 0.18974231335557 880 4497149 SGTC_3198 9112019 49.47 µM -0.878858404844627 0.258465461030448 no 2503 0.189739027079768 935 45595555 SGTC_367 0335-0881 7.1 µM -0.878908052444334 0.258453276944325 no 2504 0.189725566119729 900 23828853 SGTC_659 k018-0002 107 µM -0.879077932985443 0.25841158857663 no 2505 0.189679510830404 912 6797879 YHR007C ERG11 SGTC_3052 9092717 49.47 µM -0.879095649234096 0.258407241242885 no 2506 0.189674708281037 906 25237534 SGTC_2000 st075254 36.4 µM -0.879636286659233 0.258274594173176 no 2507 0.189528187382329 865 17234175 SGTC_2812 7970281 58.44 µM -0.879640635657368 0.258273527276093 no 2508 0.189527009020657 925 2233435 SGTC_863 0466-0191 129 µM -0.879658800634902 0.258269071064902 no 2509 0.189522087266109 906 765160 YPR165W RHO1 SGTC_2705 st078069 42.8 µM -0.880562698974068 0.25804737811246 no 2510 0.189277277635508 903 1530061 SGTC_1141 3253-0389 52.6 µM -0.882437995800853 0.257587751887129 no 2511 0.188769998083433 902 5402031 SGTC_3245 9134821 49.47 µM -0.886611682721883 0.256566329481114 no 2512 0.187644000918254 916 17014901 SGTC_1238 0333-0287 48.8 µM -0.888194466939175 0.256179528654432 no 2513 0.187218077281362 895 7226 SGTC_1373 2887-0003 58.5 µM -0.891265407450694 0.255429920387883 no 2514 0.186393401057358 914 776948 SGTC_887 0885-0007 9.62 µM -0.891725902670408 0.255317613656305 no 2515 0.186269933097448 905 5719458 SGTC_2939 9044578 71.43 µM -0.892563255690231 0.255113464056343 no 2516 0.186045551932416 910 2653634 SGTC_2321 7390090 138.78 µM -0.893949937632652 0.254775573998281 no 2517 0.18567433862219 916 649046 SGTC_258 haloperidol 50.781 µM -0.894122224484284 0.2547336095696 no 2518 0.185628249726842 910 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_3272 9137413 49.47 µM -0.89489581527733 0.254545228341488 no 2519 0.185421391986741 918 17614870 SGTC_1964 st076914 61 µM -0.895681072049287 0.2543540809365 no 2520 0.185211561179674 927 24208661 SGTC_1071 trifluoperazine 6.31 µM -0.896702497319264 0.254105557963869 no 2521 0.18493884384485 925 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_2148 5546263 113.568 µM -0.897269038931973 0.253967767665414 no 2522 0.184787686658644 915 792097 SGTC_68 0986-0284 82.829 µM -0.897710861022108 0.253860337995903 no 2523 0.18466985880992 873 423278 YIL048W NEO1 SGTC_1020 4335-0961 93.3 µM -0.899698188948462 0.253377411488462 no 2524 0.184140443722555 919 669075 SGTC_3205 9113483 49.47 µM -0.901075065235671 0.25304310990547 no 2525 0.183774204744748 911 17018033 SGTC_746 1095-0025 46.6 µM -0.901188897046824 0.253015482259925 no 2526 0.183743946640392 898 6749286 SGTC_135 0933-0004 26.348 µM -0.902265554313699 0.252754249768978 no 2527 0.183457909443891 876 21230617 YGL099W LSG1 SGTC_1546 5-methoxyflavanone 78.7 µM -0.902879629019565 0.252605318657661 no 2528 0.1832948916412 884 147795 SGTC_1326 1431-2094 10.8 µM -0.903007743895376 0.252574252875148 no 2529 0.183260892504099 913 616278 SGTC_1753 st043925 64 µM -0.904726322968342 0.252157719946832 no 2530 0.182805196128288 918 670181 SGTC_2438 5259590 200 µM -0.904965714357253 0.252099727290439 no 2531 0.182741775566288 902 1201127 SGTC_2723 salbutamol 83.58 µM -0.905452649495956 0.251981788778965 no 2532 0.182612817077235 893 9884233 β2-adrenoceptor agonist SGTC_3223 9129970 49.47 µM -0.906629405616561 0.251696891874408 no 2533 0.182301403092943 918 17248386 SGTC_178 4092-0806 87.505 µM -0.907753076432673 0.251425005971389 no 2534 0.182004347410882 879 2169044 SGTC_3124 9127567 49.47 µM -0.90844007534208 0.251258854673093 no 2535 0.181822880292287 911 17592030 SGTC_1588 farnesol 29.9 µM -0.910345408143974 0.250798352205492 no 2536 0.18132018920909 896 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2127 5253358 187.912 µM -0.910997475483134 0.250640855861417 no 2537 0.18114835191512 904 20612 SGTC_3014 9081533 49.47 µM -0.911570102896355 0.25050259016505 no 2538 0.180997533334933 913 21367265 SGTC_1909 st060837 51.5 µM -0.921644459888818 0.248076677100629 no 2539 0.178357029830257 888 678937 SGTC_1819 st053448 58.6 µM -0.925150400192123 0.247235393092133 no 2540 0.177443839776682 940 2857616 SGTC_1015 4130-4525 82 µM -0.926180004520331 0.246988619759898 no 2541 0.177176221055041 911 1363237 SGTC_2048 5246248 200 µM -0.929959497668517 0.246083890037626 no 2542 0.176196027708451 884 677046 SGTC_203 k066-0004 30.888 µM -0.930015388773307 0.246070524255539 no 2543 0.176181558419718 935 6795412 SGTC_2937 9044753 11.33 µM -0.930483792910982 0.245958525538855 no 2544 0.1760603258481 880 6465530 YGL099W LSG1 SGTC_3021 9087658 49.47 µM -0.931051673481318 0.245822778000952 no 2545 0.175913417587922 899 25237042 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.933026263686208 0.245351080407124 no 2546 0.175403204075153 913 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_861 0443-0273 110 µM -0.933785077616225 0.245169941539467 no 2547 0.175207384248135 919 6149169 SGTC_1518 st038567 90.8 µM -0.933970361837774 0.245125722684388 no 2548 0.175159590795893 927 77966 SGTC_2164 5685496 200 µM -0.935248082382634 0.244820906136941 no 2549 0.174830232170397 944 759046 SGTC_766 1391-0721 126 µM -0.936750857246551 0.244462661259747 no 2550 0.17444336456144 939 1020919 YIL115C NUP159 SGTC_1836 st055642 81 µM -0.937773607096888 0.244219010641076 no 2551 0.17418038365616 914 8571 SGTC_2009 4012297 12.05 µM -0.940875245035399 0.243480905897373 no 2552 0.173384397456069 912 45595307 SGTC_1193 1488-0126 41.5 µM -0.942200333458574 0.243165938990189 no 2553 0.173045041618616 892 1384710 SGTC_182 3448-4371 550.524 µM -0.943126112891397 0.242946016624454 no 2554 0.172808200270574 893 3491403 SGTC_865 0488-0499 301 µM -0.943715544539833 0.242806051017047 no 2555 0.172657514180381 896 9634651 SGTC_571 k831-0106 44.2 µM -0.944968400091884 0.242508694722833 no 2556 0.172337504500186 897 4783639 SGTC_2546 rhodinyl acetate 100 µM -0.946513212472823 0.242142316276208 no 2557 0.171943443245628 901 6708682 SGTC_1232 0279-0259 161 µM -0.947771784181492 0.241844046641607 no 2558 0.171622823830727 904 1560000 SGTC_1914 st062367 72.6 µM -0.948475021935753 0.241677472777063 no 2559 0.171443841425686 916 978205 SGTC_146 3448-8650 53.125 µM -0.951013677808846 0.241076667370045 no 2560 0.170798716286932 944 2891488 YIL048W NEO1 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.95365726572387 0.240451892581557 no 2561 0.170128579168057 916 688761 SGTC_76 0433-0009 400.328 µM -0.954680473352041 0.240210308785747 no 2562 0.169869653751689 970 2841569 SGTC_1144 3486-0183 12.5 µM -0.955813138139743 0.239943036008312 no 2563 0.169583324726628 933 6744069 SGTC_2878 9043973 25.97 µM -0.956090890040918 0.239877520185198 no 2564 0.169513158463499 934 6465167 SGTC_1370 2001-0092 44.6 µM -0.958978314428456 0.23919701590718 no 2565 0.168784834940625 903 790957 SGTC_2793 7325131 81.82 µM -0.959032528744047 0.239184248847941 no 2566 0.168771179189423 901 4176441 SGTC_1000 4048-0884 8.67 µM -0.961917433811882 0.238505413040772 no 2567 0.168045540209678 940 13040088 SGTC_2118 5526350 200 µM -0.963655412833616 0.238096965596423 no 2568 0.167609357661355 929 743594 SGTC_941 3237-0776 460 µM -0.964681810727178 0.237855929037629 no 2569 0.167352104241435 919 760008 SGTC_133 0724-0033 378.92 µM -0.964903641040524 0.237803852586078 no 2570 0.167296538786169 909 280309 SGTC_1650 st011916 45.8 µM -0.966663114707249 0.237391023562054 no 2571 0.16685623598181 940 242528 SGTC_412 gemfibrozil 100 µM -0.967309865740738 0.237239373962951 no 2572 0.166694576614828 905 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_2436 5633522 8.09 µM -0.972619544017142 0.235996379248152 no 2573 0.165371212749098 937 5724242 SGTC_455 paf C-16 10 µM -0.972710087968363 0.235975214092777 no 2574 0.165348705027639 919 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_1491 4138-0063 26.5 µM -0.974824854717438 0.235481173183358 no 2575 0.164823572998895 926 23883227 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.97513344412916 0.235409129864194 no 2576 0.164747035490664 928 616764 SGTC_3267 9137951 49.47 µM -0.975632314104546 0.235292689355792 no 2577 0.164623352585084 964 16643986 SGTC_2317 5986382 200 µM -0.975704658795605 0.23527580612796 no 2578 0.164605421441952 956 877883 SGTC_2689 tacrolimus 100 µM -0.979239404546245 0.23445171050347 no 2579 0.163730851465948 897 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_3225 9130819 49.47 µM -0.979391073306466 0.234416386003857 no 2580 0.163693393056654 933 4547121 SGTC_2299 7976368 114.88 µM -0.98295918210467 0.233586203722176 no 2581 0.162813764153648 932 2979718 SGTC_3064 1327-0027 10 µM -0.984331896702316 0.233267252699632 no 2582 0.162476175650625 886 16000455 YPR107C YTH1 SGTC_2889 9059656 51.95 µM -0.984569995159581 0.233211954994615 no 2583 0.162417667041475 929 3949838 SGTC_2877 9040724 71.43 µM -0.98532559956372 0.233036516165299 no 2584 0.162232081048505 935 6463895 SGTC_1659 st012954 42.1 µM -0.985922907501987 0.232897883036219 no 2585 0.162085472416114 928 24207262 SGTC_565 1418-0001 44.5 µM -0.986103655284595 0.232855941125379 no 2586 0.162041125065695 932 2862145 SGTC_3340 9146634 11.102 µM -0.986902099175118 0.232670715145322 no 2587 0.161845317533284 896 4907387 SGTC_3127 9126946 49.47 µM -0.986956515195666 0.232658094496305 no 2588 0.16183197835629 911 27243249 SGTC_1201 1889-3372 45.9 µM -0.986975475288938 0.232653697191692 no 2589 0.161827330774937 917 5392199 SGTC_1771 st048882 4.1505 µM -0.988052078842196 0.232404082567238 no 2590 0.161563571660259 936 4580403 SGTC_683 panaxydol 45 µM -0.988228285052214 0.232363242677906 no 2591 0.161520429275706 904 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_1738 st035555 74 µM -0.992715660782155 0.231324535377466 no 2592 0.160424270389424 936 5331140 SGTC_3028 9087778 49.47 µM -0.99338383358817 0.231170093092298 no 2593 0.160261468444848 916 17217395 SGTC_2975 9084847 53.72 µM -0.995868317458406 0.230596331423776 no 2594 0.159657065460646 926 27211724 SGTC_864 0469-0573 172 µM -1.0000483288905 0.22963280617129 no 2595 0.15864356003739 951 689425 SGTC_2437 5741531 144.16 µM -1.00118256213181 0.229371746091785 no 2596 0.158369277707961 899 2262990 SGTC_2551 apiole 73.87 µM -1.00391530056612 0.228743450840757 no 2597 0.157709720466639 908 10659 A possible DNA adduct former. SGTC_2915 7971052 15.16 µM -1.00392283202485 0.228741720587978 no 2598 0.157707905216155 895 5741558 SGTC_1068 loratadine 26.9 µM -1.00420353659586 0.228677237675599 no 2599 0.157640258906989 952 3957 A H1 histamine antagonist. SGTC_1628 st004252 77.7 µM -1.0043963739711 0.22863294536123 no 2600 0.157593798546562 904 692968 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -1.0046057756687 0.228584853887642 no 2601 0.157543357529863 941 521171 SGTC_84 0443-0269 128.823 µM -1.0055221254775 0.228374470611222 no 2602 0.157322750521934 891 6150058 SGTC_1365 1672-3266 55.4 µM -1.00923877199408 0.227522288318119 no 2603 0.156430068126209 909 6415873 SGTC_1247 0448-0043 5.84 µM -1.00945520520292 0.227472718029754 no 2604 0.156378187118102 944 3089013 YGL099W LSG1 SGTC_1094 duloxetine 25.4 µM -1.01306906835624 0.226645924368779 no 2605 0.155513585771946 919 60834 A selective serotonin reuptake inhibitor. SGTC_1965 Pectolinarigenin 58.4 µM -1.01336842455544 0.226577512645309 no 2606 0.155442107785612 939 5320438 An anti-inflammatory. SGTC_2780 5215298 71.43 µM -1.01450318671875 0.226318291881247 no 2607 0.155171354798234 948 2834131 SGTC_2044 5102272 200 µM -1.01613440491787 0.225945956238362 no 2608 0.154782693712977 932 592666 SGTC_3298 9116858 71.43 µM -1.01759929063394 0.225611882381964 no 2609 0.154434212303046 974 2506942 SGTC_1299 1079-1439 3.74 µM -1.01916657168352 0.225254766502543 no 2610 0.154061946860584 942 323161 SGTC_545 4218-0007 221 µM -1.02188930983008 0.224635133537876 no 2611 0.153416646318404 951 2840508 SGTC_2094 5332512 191.667 µM -1.02318239776206 0.224341195245719 no 2612 0.153110806937099 939 755774 SGTC_3156 9099931 49.47 µM -1.02336272342986 0.22430022186901 no 2613 0.15306818868639 945 18111053 SGTC_1469 k284-2957 126 µM -1.0245641816392 0.224027336484264 no 2614 0.152784436246881 899 23884841 SGTC_1990 st072050 59.8 µM -1.02511840018331 0.223901521259697 no 2615 0.152653662236147 918 17233948 SGTC_1917 st066507 28.5 µM -1.02680155122337 0.223519669091236 no 2616 0.152256959401988 937 3156428 SGTC_2733 amorolfine 100 µM -1.02687979505876 0.223501927127322 no 2617 0.152238534730133 982 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_1924 st058459 75.1 µM -1.02795084660586 0.223259144353256 no 2618 0.151986474883015 929 688683 SGTC_1606 st000094 49.2 µM -1.02972813722392 0.222856604807175 no 2619 0.151568821657814 919 1242210 SGTC_528 3492-0019 172 µM -1.02992128088619 0.222812884515455 no 2620 0.151523479996879 931 2869262 SGTC_2528 xanthyletin 44.79 µM -1.03000673149315 0.22279354334626 no 2621 0.151503422819727 960 65188 An natural product with antifungal activity of unknown mechanism. SGTC_67 0335-0847 266 µM -1.03203323460038 0.222335138484056 no 2622 0.151028274335184 958 4552207 YOR254C SEC63 SGTC_2208 7283366 200 µM -1.0323138746856 0.222271698775011 no 2623 0.150962551702177 921 898663 SGTC_2142 5622915 118.518 µM -1.03404709774636 0.221880126352179 no 2624 0.150557072934322 936 5322196 SGTC_1925 st057770 10.1 µM -1.03449124950566 0.221779846354036 no 2625 0.150453282749277 939 5989122 SGTC_808 0711-0032 135 µM -1.03454705331189 0.221767248875363 no 2626 0.150440245786563 916 4252555 SGTC_1427 4048-4900 550 nM -1.03463857794932 0.221746588451698 no 2627 0.150418865303119 935 24132586 SGTC_210 3551-0445 56.827 µM -1.03613916743307 0.221408007934241 no 2628 0.150068610914969 949 2865180 YOR207C RET1 SGTC_406 estrone 100 µM -1.03936845033154 0.220680382840722 no 2629 0.149316705607569 928 5870 A steroid. SGTC_1465 k213-0056 144 µM -1.03956287229819 0.220636619255993 no 2630 0.149271516868544 896 24048857 YMR208W ERG12 SGTC_1171 0368-0077 21.4 µM -1.040506914205 0.220424190000261 no 2631 0.149052226718668 933 3239779 SGTC_2443 5493264 126.67 µM -1.04141573206298 0.220219797686394 no 2632 0.148841322112162 953 5340055 SGTC_2055 5235184 200 µM -1.04583271984189 0.219227970155237 no 2633 0.147819135834903 930 2836034 SGTC_416 estradiol valerate 100 µM -1.04631849928521 0.219119046108543 no 2634 0.14770700357374 949 13791 A steroid. SGTC_679 0422-0091 41.4 µM -1.04708603450146 0.21894700872552 no 2635 0.147529949884759 959 627384 YHR062C RPP1 SGTC_2239 6685329 187.64 µM -1.04713100476074 0.218936931382151 no 2636 0.147519580634639 920 805680 SGTC_1713 st033146 12.748 µM -1.0474130107342 0.21887374301004 no 2637 0.147454566780275 958 674619 SGTC_663 1486-0733 13.9 µM -1.04886198948858 0.218549239467361 no 2638 0.147120820973455 938 722445 YPR165W RHO1 SGTC_46 0329-0187a 2.197 µM -1.04956066133147 0.218392868657168 no 2639 0.146960075784871 928 46494817 SGTC_1617 st002906 78 µM -1.04970334317673 0.21836094274177 no 2640 0.146927263102771 955 5150859 SGTC_85 0868-0259 160.055 µM -1.04998511284525 0.218297902992298 no 2641 0.146862478693646 917 83173 SGTC_520 3584-0023 682 µM -1.05093504813324 0.218085453195814 no 2642 0.146644211025598 933 1340790 SGTC_1654 st012436 41.8 µM -1.05132368268224 0.217998570765357 no 2643 0.146554976820137 950 4323132 SGTC_3197 9113331 49.47 µM -1.05140810215814 0.217979700739937 no 2644 0.146535598121023 937 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_3270 9137563 49.47 µM -1.05508762151407 0.217158144641483 no 2645 0.145692626399769 900 17015724 SGTC_630 4356-0227 183 µM -1.05950691414068 0.216173781805014 no 2646 0.144684491035587 940 779312 SGTC_2453 5731132 22.18 µM -1.06006119953564 0.216050501697161 no 2647 0.144558379079569 963 1362040 SGTC_2719 novobiocin 32.65 µM -1.06038883821278 0.215977649850781 no 2648 0.144483869006211 961 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_2278 7948257 134.34 µM -1.06097160127177 0.215848105194398 no 2649 0.144351403684106 932 1247028 SGTC_2125 5246583 200 µM -1.06255880255817 0.215495508498397 no 2650 0.143991039063038 945 835267 SGTC_3054 9094397 49.47 µM -1.06441989294772 0.215082493183344 no 2651 0.143569263000712 957 2598354 SGTC_3103 9120822 49.47 µM -1.06617098177502 0.214694309512829 no 2652 0.143173178584788 940 17141819 SGTC_3067 9117431 49.47 µM -1.06732528883668 0.214438644009718 no 2653 0.142912486182067 986 17150885 SGTC_1138 3761-0006 1.03 µM -1.06981693499959 0.213887377457038 no 2654 0.142350858988295 956 12061087 SGTC_1428 4049-0204 61.7 µM -1.07020990402382 0.213800510055489 no 2655 0.14226241867497 952 X1428 SGTC_2514 salinomycin 42.74 µM -1.07117376121268 0.21358753252218 no 2656 0.142045653611216 958 23682228 A polyether potassium ionophore. SGTC_996 3970-0799 1.8 µM -1.07133606857484 0.213551680637601 no 2657 0.14200917377208 956 6615648 YGL040C HEM2 SGTC_10 0279-0212 42.575 µM -1.07195383554921 0.213415254886706 no 2658 0.141870383863629 960 39851 YBR002C RER2 SGTC_2282 7944268 200 µM -1.07842831398359 0.211988510232607 no 2659 0.140421328502038 969 2970414 SGTC_3150 9097574 49.47 µM -1.08400918556197 0.210763173533835 no 2660 0.139180363065213 934 17217476 SGTC_1554 st069299 38.7 µM -1.08460484107824 0.210632637168423 no 2661 0.13904835498599 948 24207999 SGTC_1455 4262-0120 131 µM -1.08982019752335 0.209491732784783 no 2662 0.137896177546067 945 1529587 SGTC_2181 6316240 54.2555 µM -1.09060967795854 0.209319344483652 no 2663 0.137722334611166 964 12779990 SGTC_3328 9140624 29.0385 µM -1.09106528203846 0.209219898308177 no 2664 0.13762207905867 950 4904392 SGTC_2601 securinine 100 µM -1.09484331572176 0.208396326837141 no 2665 0.136792643021592 950 442872 A GABA receptor antagonist. SGTC_2598 perillyl alcohol 100 µM -1.09677775488679 0.207975380728567 no 2666 0.136369278373584 960 10819 An apoptosis inducer. SGTC_2653 dihydrofissinolide 100 µM -1.09905968443169 0.207479464442501 no 2667 0.135871016689259 962 6857746 SGTC_2099 5377090 177.372 µM -1.10082332021465 0.207096664710658 no 2668 0.135486780060807 949 2243829 SGTC_2374 9071832 200 µM -1.10308116883321 0.206607205694101 no 2669 0.134995958894568 939 17381698 SGTC_588 3970-1144 52.9 µM -1.10336855726121 0.206544954490714 no 2670 0.134933572723912 926 1888707 SGTC_693 4161-2696 114 µM -1.1038692107866 0.206436534477618 no 2671 0.134824938288264 968 805759 SGTC_1864 st057645 30.4 µM -1.10653343444314 0.205860145669048 no 2672 0.134247850423325 954 688666 SGTC_2260 7964312 200 µM -1.11213881719449 0.204650576788409 no 2673 0.133039234559823 967 231951 SGTC_1633 st005664 67.9 µM -1.1136406356148 0.204327223451272 no 2674 0.132716693111238 972 2063822 SGTC_2480 5767542 37.17 µM -1.11396903778684 0.204256556427214 no 2675 0.132646234895304 937 2867358 SGTC_857 0438-0306 1.35 µM -1.114142915761 0.204219146493206 no 2676 0.132608940059654 933 4686136 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -1.11428332364631 0.204188940643674 no 2677 0.132578829447222 938 5711223 A potent inhibitor of glutathione S-transferases. SGTC_3059 1327-0034 3 µM -1.11453322441702 0.204135186249422 no 2678 0.132525249628074 950 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_3110 9122132 49.47 µM -1.11696104502695 0.203613393720476 no 2679 0.132005490775905 957 918317 SGTC_1495 4469-0029 237 µM -1.12502075858896 0.201886894298472 no 2680 0.130290118927966 950 793680 SGTC_677 0929-0063 136 µM -1.12671617016148 0.201524833156657 no 2681 0.129931251727366 990 1539583 SGTC_73 0327-0325 16.231 µM -1.12702999588089 0.201457857261433 no 2682 0.129864899469264 903 53298 SGTC_1388 3346-4487 254 µM -1.13029358750011 0.200762140720954 no 2683 0.129176267855587 985 3345614 SGTC_1712 st032288 53.4 µM -1.13048002502225 0.200722440470568 no 2684 0.129137005331344 962 2883011 SGTC_581 0958-0271 211 µM -1.13151886743955 0.200501314302359 no 2685 0.128918383395513 959 4591145 SGTC_1198 1612-1005 86.7 µM -1.13152420828283 0.200500177838 no 2686 0.128917260091305 975 6998509 SGTC_2359 9039622 200 µM -1.13242826052985 0.200307862631124 no 2687 0.128727214588325 970 6463596 SGTC_3172 9105863 49.47 µM -1.1337212750643 0.200032997818464 no 2688 0.128455741261329 987 2348785 SGTC_2202 7226349 200 µM -1.13402444517133 0.19996858373721 no 2689 0.128392147098052 960 844334 SGTC_3320 9137005 35.139 µM -1.13436021577383 0.19989725763718 no 2690 0.128321740037995 957 4908713 SGTC_2093 5331342 194.4 µM -1.13466408888624 0.199832720554742 no 2691 0.12825804461058 953 33839 SGTC_446 go6976 132 µM -1.1351331428829 0.199733126683912 no 2692 0.12815976840599 974 3501 A protein kinase C inhibitor. SGTC_625 k213-0058 121 µM -1.13587422989878 0.199575833127553 no 2693 0.128004602452591 967 3655420 SGTC_2917 7979103 53.79 µM -1.1379551899312 0.199134554164511 no 2694 0.127569596980281 962 2980565 SGTC_2887 9044784 58.44 µM -1.13888249838375 0.198938102799185 no 2695 0.127376083147332 952 6465546 SGTC_549 1661-1316 519 µM -1.14224384787013 0.19822697666676 no 2696 0.126676337269353 975 2857282 SGTC_1688 st021091 57.6 µM -1.14265558031747 0.198139976280256 no 2697 0.126590809634953 999 3656366 SGTC_2989 9073649 71.4286 µM -1.14321247862303 0.198022338567805 no 2698 0.12647519124562 956 21367202 SGTC_1689 st020265 53.493 µM -1.14715202102039 0.197191365319127 no 2699 0.125659398505064 968 5758320 YPR016C TIF6 SGTC_775 4577-0580 57.3 µM -1.14742411326871 0.197134050512775 no 2700 0.125603190023091 976 2006902 SGTC_2895 9054447 58.44 µM -1.14774904878644 0.19706561775733 no 2701 0.125536088231537 993 2697450 SGTC_2792 7535235 81.82 µM -1.14779048267447 0.197056892643861 no 2702 0.125527533599913 966 1281891 SGTC_1323 1348-1351 11.2 µM -1.14842193516815 0.196923950840164 no 2703 0.125397211347245 957 6989654 SGTC_3333 9141820 12.094 µM -1.1487257055467 0.196860016394572 no 2704 0.125334551387701 948 1939433 SGTC_1255 0566-0045 221 µM -1.15035589105181 0.196517126570745 no 2705 0.124998659759422 959 2788469 SGTC_618 k072-0232 33.2 µM -1.15351030432624 0.195854662323974 no 2706 0.124350495298186 939 5872756 YGL099W LSG1 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -1.15436117518094 0.195676201677922 no 2707 0.124176062773125 984 6708561 SGTC_3250 9135583 49.47 µM -1.15501607651495 0.195538910701061 no 2708 0.124041921549771 971 7699353 SGTC_2724 maprotiline 69.64 µM -1.15541532815356 0.195455241842897 no 2709 0.123960193955102 944 4011 A tricyclic antidepressant. SGTC_1306 1185-0270 9.02 µM -1.1571177403861 0.195098721251577 no 2710 0.123612129790808 964 1548076 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -1.15750299271447 0.195018096269205 no 2711 0.123533458653524 970 7104 SGTC_2214 7179297 48.276 µM -1.16112920922046 0.194260200610666 no 2712 0.122794678900192 976 769744 SGTC_2804 7954240 19.48 µM -1.16284146645389 0.193902955394129 no 2713 0.122446914810926 955 828705 SGTC_2707 st078556 66.6 µM -1.16310585708269 0.193847828661441 no 2714 0.12239327801826 943 17250899 SGTC_1859 st055998 20 µM -1.16381654344619 0.193699694453865 no 2715 0.122249183176775 978 676301 SGTC_779 1360-0071 233 µM -1.16732591946393 0.19296921875907 no 2716 0.121539387584112 959 7566 SGTC_2349 9023730 187.07 µM -1.16736460328888 0.192961176116905 no 2717 0.12153157968803 983 4126287 SGTC_2972 9093619 59.92 µM -1.17389477184425 0.191606443154148 no 2718 0.120218588416484 948 25236256 SGTC_1653 st012112 65 µM -1.17471755286668 0.191436165224093 no 2719 0.120053867259126 964 720429 SGTC_2841 9004761 38.96 µM -1.17586334771926 0.191199192777864 no 2720 0.119824743672879 961 2991039 SGTC_87 0100-0052 35.5 µM -1.17656521122726 0.191054122745085 no 2721 0.119684545013673 1000 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_1182 1222-0449 220 µM -1.18280381725499 0.189767617269192 no 2722 0.1184434536931 965 658318 SGTC_1563 conessine 56.1 µM -1.18291807263201 0.189744105676856 no 2723 0.118420809180534 977 441082 An anti-amoebic, histamine inhibitor. SGTC_897 1000-0139 31.4 µM -1.19125323949684 0.188033721651411 no 2724 0.116777092395994 979 6151020 SGTC_1070 indatraline 8.81 µM -1.19175446552258 0.187931173866202 no 2725 0.116678767436687 968 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_2085 5307070 144.047 µM -1.19181467735627 0.187918857216213 no 2726 0.116666959697965 983 2840351 SGTC_1910 st062352 60.4 µM -1.19257340885725 0.187763697375843 no 2727 0.116518242556867 965 2245730 SGTC_2340 7987427 183.45 µM -1.19296686521315 0.187683267106065 no 2728 0.11644117508326 964 2239331 SGTC_2122 5258151 111.688 µM -1.1936960816952 0.1875342571056 no 2729 0.116298436892428 981 2173356 SGTC_641 4092-0595 30 µM -1.19485269486342 0.187298061736377 no 2730 0.116072293977975 992 786260 SGTC_2100 5377183 190 µM -1.19681756318535 0.18689723205871 no 2731 0.115688835548051 950 2844202 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -1.19692644409508 0.186875036077819 no 2732 0.115667612985561 980 688751 SGTC_352 k048-0007 5.11 µM -1.2004899755782 0.186149490886488 no 2733 0.114974551767118 976 6811911 SGTC_2783 7738165 71.43 µM -1.20071770638811 0.186103183671644 no 2734 0.114930361659725 968 17201110 SGTC_3079 9117512 49.47 µM -1.20117497719321 0.186010222924459 no 2735 0.114841666865363 1022 7185044 SGTC_2207 7258803 200 µM -1.20140961882719 0.185962532693975 no 2736 0.114796173374235 971 3666799 SGTC_2582 agaric acid 100 µM -1.20151861310481 0.185940382502624 no 2737 0.114775045381355 959 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_2357 9067248 200 µM -1.20572582754934 0.185086628629786 no 2738 0.113961611514596 1009 9150235 SGTC_1393 3470-5649 58.2 µM -1.20590642483759 0.185050035306779 no 2739 0.113926786538685 959 4108395 SGTC_2644 guaiazulene 100 µM -1.20806481350603 0.184613042143557 no 2740 0.113511166427622 961 3515 A coloring agent. SGTC_1634 st006576 41 µM -1.20867181376777 0.18449026294251 no 2741 0.113394477260832 962 3915356 SGTC_569 4130-2812 160 µM -1.20936167209375 0.184350785546648 no 2742 0.113261963435057 973 743552 SGTC_164 4100-3994 89.624 µM -1.20944094622585 0.184334761895014 no 2743 0.113246742868504 997 4615967 SGTC_737 1950-0117 57.9 µM -1.21234116136482 0.183749138346829 no 2744 0.112690906884909 972 5393513 SGTC_3082 9117008 49.47 µM -1.21322503494887 0.183570893595526 no 2745 0.112521897523138 965 41448529 SGTC_3168 9103419 49.47 µM -1.2141823195412 0.183377966144437 no 2746 0.112339055246727 982 16649256 SGTC_186 3455-3465 67.277 µM -1.21436362370909 0.18334144104381 no 2747 0.112304449901757 968 755278 SGTC_131 0141-0277 33.849 µM -1.21617082879167 0.182977613856429 no 2748 0.111959926818385 991 1547771 SGTC_259 usnic acid 108.925 µM -1.21626034103607 0.182959604936178 no 2749 0.111942881992042 1008 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1558 st069300 45.6 µM -1.2179633283157 0.182617192559591 no 2750 0.111618954361877 961 24208000 SGTC_265 mycophenolic acid 32.932 µM -1.21889029587121 0.182430979460474 no 2751 0.111442916675117 1002 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_475 α-linolenic acid 10 µM -1.21939052575428 0.182330540496355 no 2752 0.111348002073201 962 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2759 disulfiram 3.38 µM -1.22054609398752 0.182098651153906 no 2753 0.111128963546746 952 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_404 fumagillin 50 µM -1.22068411399095 0.182070966835597 no 2754 0.111102822428715 963 12015870 A methionine aminopeptidase binder. SGTC_2320 7373003 200 µM -1.22079091889424 0.182049545508284 no 2755 0.111082596502419 960 5415828 SGTC_432 NS 1619 61.3 µM -1.22374289726701 0.181458105665615 no 2756 0.110524615839094 962 4552 A K+/calcium channel activator. SGTC_845 0330-0138 4.51 µM -1.22462549534497 0.181281507696091 no 2757 0.110358178661102 972 9039800 SGTC_3104 9120930 49.47 µM -1.22495986720095 0.181214631761445 no 2758 0.110295170980832 988 17014836 SGTC_2401 5128683 200 µM -1.22512643033768 0.181181324121734 no 2759 0.110263794124981 991 708373 SGTC_489 paxilline 115 µM -1.23295892627614 0.179619391147297 no 2760 0.108795544375831 988 105008 A toxic potassium channel blocker. SGTC_2425 5628681 7.85 µM -1.2335328000033 0.179505284626056 no 2761 0.108688523578938 983 5714958 SGTC_1751 st044839 27.194 µM -1.23694979561405 0.178826807969875 no 2762 0.108052860827109 972 5291326 SGTC_3033 9090887 49.47 µM -1.23790522206497 0.178637388202584 no 2763 0.107875602905976 983 19325384 SGTC_189 3970-0742 2.116 µM -1.23902460654137 0.178415623438182 no 2764 0.107668192791772 973 2891807 SGTC_579 4491-1009 110 µM -1.24344627412558 0.177541329714608 no 2765 0.106851713635877 1004 1271041 SGTC_410 α-linolenic acid 100 µM -1.24552686352083 0.177130873149131 no 2766 0.106469073615953 987 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_474 dl-dihydrosphingosine 5 µM -1.24798977368381 0.176645768174151 no 2767 0.106017401108027 958 3058739 A sphingolipid protein kinase C inhibitor. SGTC_1052 3253-3998 198 µM -1.24851570149053 0.176542288206785 no 2768 0.10592113098916 987 5450317 SGTC_983 1491-0821 12.2 µM -1.24908701732144 0.176429921283193 no 2769 0.105816624284116 978 46495113 SGTC_223 busulfan 5 mM -1.24927520224764 0.17639291880671 no 2770 0.105782217289538 969 2478 A DNA alkylator. SGTC_218 alverine citrate 93.75 µM -1.24976270300979 0.176297085210962 no 2771 0.105693122173403 978 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1755 st041960 45.185 µM -1.25543236917052 0.175184954806378 no 2772 0.104660922455928 989 2257073 SGTC_1147 3809-1045 12.3 µM -1.2596386176222 0.174362761897843 no 2773 0.10389987892225 994 325925 SGTC_215 1287-0124 461.5 µM -1.26160546216068 0.17397914651976 no 2774 0.103545394862875 999 5560863 SGTC_2533 agelasine 13.65 µM -1.26467362022126 0.173381802178673 no 2775 0.102994175068556 964 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_1976 st070609 63.5 µM -1.26800347650642 0.172734986680591 no 2776 0.102398354530808 983 682556 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -1.27203209251107 0.171954498009586 no 2777 0.10168085846272 993 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2303 7774051 200 µM -1.27234969484501 0.171893062843729 no 2778 0.101624449575979 987 2953184 SGTC_552 k242-0005 476 µM -1.27338235885407 0.171693407150848 no 2779 0.101441197129355 997 4088318 SGTC_1874 staurosporine 7.6 µM -1.27460334844134 0.171457531718707 no 2780 0.101224835859543 972 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_1782 st039423 80.636 µM -1.27775047862599 0.170850512470807 no 2781 0.100668710223424 1006 2068169 SGTC_947 3447-0010 211 µM -1.27786446455978 0.170828552672387 no 2782 0.100648609806588 990 748350 SGTC_3171 9103192 49.47 µM -1.27913385698312 0.170584121744595 no 2783 0.100424961420075 1006 13018434 SGTC_1320 1313-0481 95.3 µM -1.27918760529357 0.170573777052444 no 2784 0.100415499762266 982 6813365 YLR208W SEC13 SGTC_972 1319-0219 195 µM -1.28021620139011 0.17037588524993 no 2785 0.100234554755947 998 23903702 SGTC_1434 4073-0095 163 µM -1.28286615911953 0.169866737113665 no 2786 0.0997694853176604 982 24133745 SGTC_105 0111-0055 734.78 µM -1.28600395714782 0.169265120918668 no 2787 0.099220840323155 996 5179370 SGTC_1829 berberine 14.4 µM -1.28664820321528 0.169141767810072 no 2788 0.0991084671954753 941 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_3146 9095609 49.47 µM -1.28831587125303 0.168822729361983 no 2789 0.0988180152653014 997 17173999 SGTC_951 1171-0579 82.7 µM -1.28926207374732 0.16864188517822 no 2790 0.0986534956865411 972 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_3252 9135871 49.47 µM -1.28939904453743 0.168615716778561 no 2791 0.0986296967115024 996 17682838 SGTC_1507 4075-3230 155 µM -1.28941548758281 0.168612575494599 no 2792 0.0986268399788783 977 659771 SGTC_1887 st057648 70.8 µM -1.29197329602427 0.168124389144621 no 2793 0.0981831962911772 992 688672 SGTC_1358 1509-0022 2.48 µM -1.29231025507224 0.168060144606232 no 2794 0.098124860974229 983 3258434 SGTC_3268 9137683 49.47 µM -1.29325513918168 0.167880077483877 no 2795 0.097961415372272 1041 1953228 SGTC_598 3937-0236 20.2 µM -1.2939277483908 0.167751973652187 no 2796 0.0978451893737529 992 1379313 SGTC_1922 5578187 25 µM -1.29551153234563 0.167450577944154 no 2797 0.0975719128377675 939 1350412 SGTC_2105 5350118 200 µM -1.29778434693115 0.167018669008759 no 2798 0.0971807249712213 991 2133313 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -1.30934116972972 0.164833621314284 no 2799 0.0952094048969129 948 4000243 SGTC_1746 st038117 42 µM -1.30945220021091 0.164812718988806 no 2800 0.0951906096052168 994 2898218 SGTC_1447 4239-0816 81.9 µM -1.31198360032676 0.164336629650081 no 2801 0.0947628339938574 979 1341554 SGTC_1426 4048-4480 71.7 µM -1.31413461282154 0.163932782600849 no 2802 0.0944004539754549 995 14224343 SGTC_2833 9001315 45.46 µM -1.31543604300108 0.163688755380604 no 2803 0.0941816994165291 990 2989378 SGTC_2557 derrustone 83.84 µM -1.31772501955679 0.163260128773066 no 2804 0.0937978579741009 994 629853 An antioxidant. SGTC_967 1306-0166 352 µM -1.31939520513019 0.162947835642216 no 2805 0.0935185119651897 1000 4437607 SGTC_1403 3909-7815 62.9 µM -1.32325725884863 0.162227192981378 no 2806 0.0928749200861181 979 6615483 SGTC_100 0086-0128 49.5915 µM -1.3240889965368 0.162072266270064 no 2807 0.0927367447643444 1001 93297 SGTC_2701 st077767 14.721 µM -1.3241355117984 0.162063604778097 no 2808 0.0927290217457205 995 5721188 SGTC_2015 5119600 184 µM -1.32434900669299 0.162023854288474 no 2809 0.0926935808780891 1003 2828786 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -1.32475802918782 0.161947716368608 no 2810 0.0926257097579191 997 6708760 SGTC_1278 0874-0585 172 µM -1.32867348365851 0.161220049692637 no 2811 0.0919778583965968 1010 766306 SGTC_1567 st069303 68.4 µM -1.32933824895938 0.161096718686957 no 2812 0.091868200308839 995 5581319 SGTC_3001 9076041 71.4286 µM -1.329899861799 0.160992573096025 no 2813 0.0917756334875816 999 16004211 SGTC_1695 st026914 34.495 µM -1.33111586424269 0.160767227983879 no 2814 0.091575444872087 1009 3289191 SGTC_2037 5169046 200 µM -1.33175079679122 0.160649646498527 no 2815 0.0914710455801268 997 5718022 SGTC_103 0844-0104 51.839 µM -1.33418137749737 0.160200052832047 no 2816 0.0910722105612797 981 5375804 SGTC_1372 2752-0194 270 µM -1.34593587461635 0.158037397681843 no 2817 0.0891615989842937 991 823334 SGTC_1152 3909-8331 15.9 µM -1.34598933835951 0.158027605126876 no 2818 0.0891529774977373 983 16001939 SGTC_716 1683-5115 658 µM -1.34633080645255 0.157965070360848 no 2819 0.0890979274768106 997 723597 SGTC_3229 9132204 49.47 µM -1.35338747557464 0.15667638488121 no 2820 0.0879659382455481 1023 17682924 SGTC_1876 myriocin 605 nM -1.35342744321992 0.156669105772802 no 2821 0.087959557558048 996 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_1251 0490-5699 265 µM -1.35454860343163 0.156465005147313 no 2822 0.0877807090617223 1006 3883818 SGTC_2820 7989630 71.43 µM -1.35470010298245 0.156437438978909 no 2823 0.0877565625347647 979 2984098 SGTC_505 gw-5074 63.9 µM -1.35867136728581 0.155715986568753 no 2824 0.0871253745621763 1000 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_2732 terfenadine 20 µM -1.3638459881647 0.154779219834887 no 2825 0.086308021472339 1033 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_566 0958-0068 16.5 µM -1.36393363038183 0.154763386007748 no 2826 0.0862942275708461 984 6815365 SGTC_1325 1431-0015 227 µM -1.36568011047241 0.154448082407186 no 2827 0.0860196948805403 999 1103340 SGTC_3349 9149703 23.001 µM -1.36677670866744 0.154250323466907 no 2828 0.0858476527152757 1011 4910494 SGTC_1134 3477-0009 42.5 µM -1.36897601149663 0.153854209289278 no 2829 0.0855033867658688 993 3973534 SGTC_2305 7443522 69.23 µM -1.36897649676727 0.153854121962038 no 2830 0.0855033109187122 988 5415886 SGTC_1999 st074831 12.5 µM -1.3735485417408 0.153032812307437 no 2831 0.0847909407709239 996 17112523 SGTC_481 bay k-8644 50 µM -1.37855583358175 0.152136656651239 no 2832 0.0840158709739603 1005 2303 A calcium channel antagonist. SGTC_2210 7115885 190.385 µM -1.38065242493466 0.151762466545253 no 2833 0.0836929279228987 1022 2927039 SGTC_891 0929-0073 133 µM -1.38715613888797 0.150605607320459 no 2834 0.0826970783458237 1020 5603632 SGTC_986 1493-0483 84 µM -1.38866409860283 0.150338217376438 no 2835 0.082467458031024 1007 40079 SGTC_682 0kpi-0099 17 µM -1.39222383615245 0.14970826366811 no 2836 0.0819273134504695 999 1714895 YML126C ERG13 SGTC_3098 9119039 49.47 µM -1.39711362037777 0.148845811373805 no 2837 0.0811897033002118 996 17161528 SGTC_920 mycophenolic acid 780.421 nM -1.39741130410536 0.148793413828746 no 2838 0.0811449608874912 1012 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2869 9037858 32.47 µM -1.39813476958925 0.148666122634532 no 2839 0.0810363002515007 1006 27187042 SGTC_873 0591-4978 488 µM -1.3982801334831 0.148640555156608 no 2840 0.0810144806298605 1015 3305145 SGTC_289 k017-0060 526 µM -1.40553081694958 0.147368990888151 no 2841 0.0799317460749562 1018 5512909 SGTC_3121 9125696 49.47 µM -1.40915720907659 0.146735767178648 no 2842 0.0793943437904306 1045 1235365 SGTC_424 splitomicin 100 mM -1.4107972244655 0.146449995690232 no 2843 0.0791522065666495 1020 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_841 0251-0215 91.2 µM -1.41226278985768 0.146194938306704 no 2844 0.0789362992004989 1021 3888614 SGTC_2616 abietic acid 100 µM -1.41669826051082 0.145424836800475 no 2845 0.0782855829235858 1018 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_127 0180-0333 59.125 µM -1.41677372368127 0.145411758277731 no 2846 0.0782745472204101 947 771601 SGTC_2948 9070189 9.45 µM -1.41679313029287 0.145408395045595 no 2847 0.0782717093961883 969 6473636 YDL196W YDL196W SGTC_927 2425-1185 123 µM -1.41727295860214 0.145325255799206 no 2848 0.0782015690273816 1007 730375 SGTC_773 4358-1457 44.6 µM -1.41867680104989 0.145082197468177 no 2849 0.0779966318395309 1035 1186886 SGTC_112 phenothiazine 287.218 µM -1.42230889907846 0.144454613958992 no 2850 0.0774682983003226 1011 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_3072 9116419 49.47 µM -1.42658064906557 0.143718850384187 no 2851 0.0768504026161807 1006 17170162 SGTC_1853 st056710 91.2 µM -1.4288360578297 0.143331401979797 no 2852 0.0765256795804471 1014 269167 SGTC_561 1550-0330 72.9 µM -1.43494314692625 0.142285830881602 no 2853 0.0756516495763831 1021 6812934 SGTC_2893 9048488 25.97 µM -1.43554225460973 0.142183538646904 no 2854 0.0755663182162899 1039 6467338 SGTC_862 0452-0056 10.2 µM -1.43626765524166 0.142059749655255 no 2855 0.0754630970359039 1036 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_1607 st000305 50.6 µM -1.43718185378236 0.141903846395707 no 2856 0.075333163863042 1008 5457690 SGTC_1699 st031318 29.054 µM -1.44072666121638 0.141300426845248 no 2857 0.0748309598353529 1013 5340658 SGTC_2752 diclazuril 33.15 µM -1.44655442229025 0.140312173705255 no 2858 0.0740108796157601 994 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_2415 st077333 57.7 µM -1.44735752322784 0.140176355307711 no 2859 0.073898407974824 997 2766255 SGTC_562 3772-2733 112 µM -1.44906776000471 0.139887422063675 no 2860 0.0736593302329678 1007 2876874 YIL048W NEO1 SGTC_1807 st050092 58.9 µM -1.45072529000719 0.139607779792301 no 2861 0.0734281851797869 1020 5008496 SGTC_2761 levamisole 97.89 µM -1.45616258592818 0.138693122446363 no 2862 0.0726738397900278 1019 26879 An alkaline phosphatase inhibitor. SGTC_1540 guanosine 70.6 µM -1.45696309588463 0.138558806846849 no 2863 0.0725632837201317 1010 6802 Guanosine is a purine nucleoside SGTC_201 4262-0159 12.803 µM -1.46048353213954 0.13796917360709 no 2864 0.0720786151034812 1042 1341029 SGTC_2290 7904846 200 µM -1.46256793415047 0.137620867670538 no 2865 0.0717928214023211 1004 2962154 SGTC_2875 9039966 71.43 µM -1.46297873921295 0.137552292538606 no 2866 0.0717365983217455 1022 6463691 SGTC_1716 st033144 30.6155 µM -1.46876207282338 0.136589363946309 no 2867 0.0709486672696007 1021 674617 SGTC_721 1187-1332 279 µM -1.47232448013495 0.1359985205748 no 2868 0.070466637861939 1029 25730 SGTC_2265 7929201 200 µM -1.47378362493293 0.135757019834808 no 2869 0.0702699293028213 1015 1265108 SGTC_1188 1403-0014 4.57 µM -1.47394729927411 0.135729948687005 no 2870 0.0702478905918419 996 9614867 SGTC_585 0kpi-0023 191 µM -1.47473221562541 0.1356001777273 no 2871 0.0701422756569719 1005 64601 SGTC_1368 1852-0141 284 µM -1.47626806171241 0.135346500799359 no 2872 0.0699359722452129 1031 2838987 SGTC_761 k216-0224 480 µM -1.47696597073125 0.13523133416598 no 2873 0.0698423796440251 1044 1340404 SGTC_325 2810-4341 181 µM -1.47813977542506 0.135037788360833 no 2874 0.0696851848259929 1000 774970 SGTC_943 3253-1379 105 µM -1.48045604973679 0.134656421048849 no 2875 0.0693757907320963 1002 668464 SGTC_1647 st011722 22.4 µM -1.48063551638902 0.134626903311703 no 2876 0.0693518628840774 1004 2854783 SGTC_2641 levomentholum 100 µM -1.48118522806048 0.134536517244099 no 2877 0.0692786107322749 1025 16666 SGTC_317 4495-0002 170 µM -1.48143685734779 0.13449515712529 no 2878 0.0692450996167806 1007 15991618 SGTC_1060 3448-7350 82 µM -1.48169389262703 0.134452917440807 no 2879 0.0692108814450978 1011 570178 SGTC_1943 st076331 65.2 µM -1.48317686909178 0.134209391572085 no 2880 0.0690137125455929 1038 24208415 SGTC_216 k038-0035 28.382 µM -1.48363238069791 0.134134650934053 no 2881 0.0689532370632158 1025 4444231 YPR107C YTH1 SGTC_1796 st049173 110.4 µM -1.48507366175806 0.133898352997216 no 2882 0.0687621560965763 1012 94134 SGTC_831 k061-1017 217 µM -1.48525675804406 0.133868354865972 no 2883 0.0687379109662589 1050 1240153 SGTC_724 3910-0327 137 µM -1.48667977301448 0.133635368378989 no 2884 0.0685497036984268 1027 2885483 SGTC_487 nimodipine 119 µM -1.49127619655426 0.132884713560685 no 2885 0.0679444978731153 1052 4497 L-type voltage-gated calcium channels inhibitor SGTC_2836 9010338 19.48 µM -1.49176574237195 0.132804935873878 no 2886 0.0678802838165441 1017 2994051 SGTC_1635 st007035 42.4 µM -1.49186066522986 0.132789470811278 no 2887 0.0678678381475614 968 3716403 SGTC_1833 st055984 71 µM -1.49683285901606 0.13198112245972 no 2888 0.0672183769829119 1022 676288 SGTC_2165 5727197 32.143 µM -1.49726124098982 0.131911637916173 no 2889 0.0671626479192024 1021 1361712 SGTC_1969 st069479 40.1 µM -1.49730963966482 0.131903789126297 no 2890 0.0671563538860916 1015 3895485 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -1.510010455906 0.12985523007475 no 2891 0.0655203781041095 973 688669 SGTC_646 4092-0839 27.3 µM -1.51153155577928 0.129611371759132 no 2892 0.0653265375321091 1017 877796 SGTC_2119 5528445 120.635 µM -1.5118884895699 0.129554195151361 no 2893 0.0652811163673098 1038 791935 SGTC_2991 9074669 71.4286 µM -1.51653032144607 0.128812219108345 no 2894 0.0646926546143854 1009 17333109 SGTC_3040 9091894 49.47 µM -1.51663176506162 0.128796036782923 no 2895 0.0646798403933925 1005 25236966 SGTC_2941 9056145 11.23 µM -1.51956253073099 0.128329128740264 no 2896 0.0643104805157397 1010 2119517 SGTC_345 1362-0200 395 µM -1.52074293424646 0.128141407919866 no 2897 0.0641621799596168 1031 1419823 SGTC_706 4262-0057 46.9 µM -1.52075576675246 0.128139368201374 no 2898 0.0641605692035808 1038 883298 SGTC_2621 lithochol-11-enic acid 100 µM -1.52433199828969 0.127571807163281 no 2899 0.0637128988633415 1031 6708711 SGTC_44 0929-0055 61.211 µM -1.52566064427614 0.127361392148465 no 2900 0.0635472002888114 991 1379590 SGTC_2916 7875993 68.79 µM -1.52641324323464 0.12724231170237 no 2901 0.0634534907846809 1007 1299250 SGTC_1852 st056254 31.4 µM -1.52851811381787 0.126909678554393 no 2902 0.0631919748344116 1031 442583 SGTC_123 0083-0120 66.675 µM -1.52887532456917 0.126853288596812 no 2903 0.0631476772303312 1046 16001701 SGTC_348 k064-0012 10.7 µM -1.5300911414261 0.126661488206983 no 2904 0.062997085333294 1016 5066323 SGTC_2062 5245942 200 µM -1.53211790228221 0.126342207008999 no 2905 0.0627466713882563 1034 1376160 SGTC_1423 4048-0112 5.59 µM -1.53317743233549 0.126175519742839 no 2906 0.0626160715685055 1029 X1423 SGTC_323 4013-0906 34.3 µM -1.53745555813814 0.125504036250003 no 2907 0.0620908950522024 1009 2910086 SGTC_57 miconazole 162.5 nM -1.53934464200132 0.125208325724187 no 2908 0.0618600904445828 1001 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_1702 st027038 51 µM -1.54038970579296 0.125044944304029 no 2909 0.0617326945803537 1028 5521182 SGTC_2395 5646831 180.19 µM -1.5420425956752 0.124786841705595 no 2910 0.0615316214870147 1041 6808628 SGTC_1576 erythromycin ethylsuccinate 23.2 µM -1.5431658642693 0.124611653303327 no 2911 0.0613952686745601 1014 3256 An antibiotic and ribosome inhibitor. SGTC_1436 4092-1007 8.32 µM -1.5432514416592 0.124598313443536 no 2912 0.0613848901771865 1020 2881121 SGTC_1322 1348-1070 12 µM -1.54676127379086 0.124052058376796 no 2913 0.0609604108329096 1023 6758089 SGTC_55 0767-0285 6.563 µM -1.55022812356732 0.123514140150133 no 2914 0.0605433859604928 1013 3116166 SGTC_1920 st075728 45.7 µM -1.55430760224585 0.122883260997809 no 2915 0.0600555305024441 1006 3400306 SGTC_3287 9117173 37.0625 µM -1.56315458702903 0.121522873799854 no 2916 0.0590081193872916 976 2789709 SGTC_3300 9124615 50.48 µM -1.56421530591415 0.121360482189029 no 2917 0.0588835069549532 1028 24824903 SGTC_804 1595-0054 20.9 µM -1.56520405148442 0.121209246849628 no 2918 0.0587675359299529 1035 761523 Stimulates phospholipase C. SGTC_51 1013-0126 23.419 µM -1.56540538171422 0.121178468275845 no 2919 0.0587439436736463 1025 1627850 SGTC_2757 clomiphene 4.22 µM -1.56647022780773 0.121015770219563 no 2920 0.058619286608806 1036 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_2296 7971656 126.45 µM -1.56809353909156 0.120768039985539 no 2921 0.058429652073767 1024 666570 SGTC_1452 4194-0072 190 µM -1.57326947402783 0.119980535420102 no 2922 0.0578282172504093 1032 1343545 SGTC_2871 9038510 12.99 µM -1.57449456411096 0.119794672212145 no 2923 0.0576865786265091 1029 4945164 SGTC_2593 nobiletin 86.24 µM -1.57861968236882 0.119170327414878 no 2924 0.0572116586565306 1014 72344 An anti-infammatory. SGTC_3228 9131799 49.47 µM -1.58007201883632 0.118951061090939 no 2925 0.0570451872044599 1047 17015818 SGTC_3057 9095946 49.47 µM -1.58289320455106 0.118525947483221 no 2926 0.0567229039339695 1047 24540043 SGTC_1766 st045414 44.774 µM -1.58595074734091 0.118066431792929 no 2927 0.0563752413515363 1010 253960 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -1.58887583836944 0.117628002883635 no 2928 0.0560442135357283 1049 6708784 An antioxidant flavonoid SGTC_3251 9135047 49.47 µM -1.59198717217298 0.117162925052488 no 2929 0.0556937934477239 1041 17682963 SGTC_1226 3909-7979 35.4 µM -1.59830765738638 0.116222162362054 no 2930 0.0549872620384832 1023 6615510 SGTC_1035 k081-0041 55.2 µM -1.60073802655955 0.115861848622609 no 2931 0.0547174774993351 1038 731709 SGTC_301 4119-0100 24.5 µM -1.60182841282288 0.115700451724702 no 2932 0.0545967791017596 1041 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_1234 0326-0494 15.5 µM -1.60194977316836 0.115682498078436 no 2933 0.0545833583611579 1031 1547813 SGTC_1762 st045503 25.4615 µM -1.60497036095089 0.11523627978652 no 2934 0.0542501637650014 1047 4645554 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -1.60638392563399 0.115027880834665 no 2935 0.0540947902502002 1060 442882 SGTC_3038 9091290 49.47 µM -1.60810336962314 0.114774748182664 no 2936 0.0539062706755429 1027 25236843 SGTC_1405 3909-7894 12 µM -1.60879400395783 0.11467318620343 no 2937 0.0538306962144242 991 7104060 SGTC_2399 5884133 200 µM -1.6094665141782 0.114574350956768 no 2938 0.053757185680815 1034 722445 SGTC_473 2-arachidonoylglycerol 10 µM -1.61013452167522 0.11447623748618 no 2939 0.0536842460561777 997 5282280 An endocannabinoid. SGTC_1192 1488-0095 21.4 µM -1.61075846550673 0.114384649891045 no 2940 0.0536161885593833 1040 915875 SGTC_1041 0206-0046 107 µM -1.61078546314306 0.114380688134296 no 2941 0.0536132452999295 1031 50494 SGTC_2319 6033012 152.6 µM -1.61103484658194 0.114344097085871 no 2942 0.0535860637798217 1029 847246 SGTC_827 3253-0474 693 µM -1.61432243819441 0.113862500742341 no 2943 0.0532287527877301 1037 5402065 SGTC_2033 5192550 145 µM -1.61746820303918 0.113403035413341 no 2944 0.0528886269633154 1013 182073 SGTC_1787 fluconazole 80 µM -1.61962094334374 0.113089372676837 no 2945 0.0526568639438789 1001 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_3263 9137018 49.47 µM -1.62619885327183 0.112134782664248 no 2946 0.0519536800253507 1023 43844957 SGTC_2379 9035213 200 µM -1.62971954311772 0.111626230974245 no 2947 0.0515803924985808 1029 646551 SGTC_2152 5568786 200 µM -1.63696209090093 0.110585263006576 no 2948 0.0508191953976107 1044 5399883 SGTC_1989 st071868 50.2 µM -1.63740282851733 0.110522141346896 no 2949 0.0507731638029372 1028 16414057 SGTC_3034 9090421 49.47 µM -1.64519450583356 0.109410492976709 no 2950 0.0499648530931702 1029 17173761 SGTC_1557 sumaresinolic acid 42.3 µM -1.64520438771912 0.109409088233552 no 2951 0.0499638344982002 1032 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_2993 9054257 71.4286 µM -1.6479092232611 0.109025073709034 no 2952 0.0496856502317121 1015 6470217 YGL055W OLE1 SGTC_1902 st060212 70.5 µM -1.65043049077923 0.108667994207816 no 2953 0.0494274595596194 1016 688944 SGTC_2036 5160441 105 µM -1.65983237940739 0.10734385086927 no 2954 0.0484740889592427 1018 134534 YIL048W NEO1 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -1.66073190948544 0.107217775152515 no 2955 0.0483836508611321 1045 689007 SGTC_2914 7968218 45.32 µM -1.66485051407345 0.106641886146285 no 2956 0.0479712915432928 1021 2977111 SGTC_3243 9134147 49.47 µM -1.66881402669279 0.106089794349827 no 2957 0.0475771210033347 1024 24282180 SGTC_2183 6420625 130.508 µM -1.67083425633027 0.1058091851995 no 2958 0.0473772100758087 1030 2897619 SGTC_799 1310-0557 151 µM -1.67459967056602 0.105287603185484 no 2959 0.0470064019802879 1040 5354492 SGTC_368 fentichlor 4.58 µM -1.67501311408393 0.105230446873969 no 2960 0.0469658293315268 1066 7329 A pesticide. SGTC_24 0417-1663 219 µM -1.68180365834098 0.104294901818098 no 2961 0.0463034595545565 1064 4329390 SGTC_1085 doxorubicin 7.67 µM -1.68329036902862 0.104090881955789 no 2962 0.0461594469575132 1020 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1273 0849-0096 14.1 µM -1.68751639874715 0.10351252859956 no 2963 0.0457520496952731 1046 5286025 SGTC_176 1486-1328 72.834 µM -1.68796773015343 0.103450899743226 no 2964 0.0457087118300004 1022 22310231 SGTC_25 0118-0223 35.662 µM -1.688091948654 0.103433942504708 no 2965 0.0456967898802858 1044 5333628 SGTC_2371 9071574 200 µM -1.69029524082557 0.103133503254472 no 2966 0.0454857425750376 1059 45596039 SGTC_245 methotrexate 289.6 µM -1.69337744592158 0.102714280255568 no 2967 0.0451918225644037 1034 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_1131 3454-3128 32.3 µM -1.69556047021605 0.102418108561368 no 2968 0.0449845746358907 1020 710982 SGTC_3301 9125354 19.7965 µM -1.69821317861058 0.102059051034251 no 2969 0.0447337670630245 1038 41905162 SGTC_1221 2958-7315 257 µM -1.70135425172711 0.101635076279415 no 2970 0.044438243172415 1050 4562705 SGTC_307 1501-1223 22.3 µM -1.701791366526 0.101576177341116 no 2971 0.0443972427517085 1048 2830329 SGTC_1794 st048918 76.9 µM -1.70437960514876 0.101227934963366 no 2972 0.0441550958034343 995 672303 SGTC_703 3875-0075 71.8 µM -1.70735891183978 0.100828153167602 no 2973 0.0438776812117586 1073 2850814 SGTC_2184 6075246 200 µM -1.70826480667054 0.100706823150723 no 2974 0.0437936091694767 1043 2267320 SGTC_1956 st077085 54 µM -1.71100997021829 0.100339803038191 no 2975 0.0435396361591058 1046 24208685 SGTC_120 rhodamine 6G 52.259 µM -1.71282380064217 0.10009783553612 no 2976 0.043372480049376 1044 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_3211 9128781 49.47 µM -1.71654754630348 0.0996024183062742 no 2977 0.0430309367552899 1023 17194361 SGTC_2521 angolensin 13.4 µM -1.72053817562858 0.0990734857360689 no 2978 0.0426673302681707 1043 821428 A flavenoid. SGTC_1528 arabinosylhypoxanthine 74.6 µM -1.72267667769915 0.0987908877399965 no 2979 0.0424735050780188 1038 804 An inhibitor of viral and cellular DNA polymerases. SGTC_2709 st078560 56 µM -1.72318722139024 0.0987235079063976 no 2980 0.0424273369146657 1055 17250903 SGTC_2741 miltefosine 3.04 µM -1.72692496574736 0.0982312372540948 no 2981 0.0420905700315952 1040 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_593 1203-0218 61.7 µM -1.7276811167721 0.0981318692381863 no 2982 0.0420227054182532 1060 3666956 SGTC_224 benfluorex 43.875 µM -1.73061450262856 0.0977470813962496 no 2983 0.0417602716539813 1064 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_2684 capsaicin 100 µM -1.73569757546006 0.0970829287264702 no 2984 0.041308661217507 1040 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1971 st069429 63.5 µM -1.73972516293646 0.0965590419359761 no 2985 0.0409536443632497 1040 1246522 YGL099W LSG1 SGTC_1499 4480-0877 67.3 µM -1.74101382653777 0.0963918588983058 no 2986 0.0408405774709902 1038 2861909 SGTC_643 k048-0106 28.4 µM -1.74516037054569 0.0958553560876702 no 2987 0.0404784786692245 1046 6763920 SGTC_1492 4158-0558 28.5 µM -1.7461091467467 0.0957329075374391 no 2988 0.0403959938610567 1027 3967268 SGTC_359 0081-0058 15.9 µM -1.747379024765 0.0955691978982019 no 2989 0.0402858067114365 1042 3494159 SGTC_183 3914-0051 30.55 µM -1.75464386000384 0.0946365919036257 no 2990 0.0396601221357111 1044 1596232 SGTC_1396 3511-0007 98.6 µM -1.76040346979145 0.0939019962838225 no 2991 0.0391697107292154 1041 X1396 SGTC_2486 5283202 22.39 µM -1.76613227161509 0.0931755132533774 no 2992 0.038686830214734 1032 1377751 SGTC_1032 k061-1018 98.7 µM -1.77024355005392 0.0926567179217232 no 2993 0.0383432886749823 1054 4005393 SGTC_1280 0880-0253 10.1 µM -1.77382504856964 0.0922065186143453 no 2994 0.0380460467399521 1041 6836607 SGTC_2352 9027995 87.8 µM -1.77578089526162 0.0919613505674898 no 2995 0.0378845189044118 1039 2997347 SGTC_1461 k072-0203 53.8 µM -1.77596811532149 0.0919379076185369 no 2996 0.0378690863213677 1031 5418714 SGTC_27 0485-0001 32.618 µM -1.78181851492575 0.0912075722144852 no 2997 0.0373894159764138 1033 2054479 SGTC_2825 7998094 58.44 µM -1.78309324104521 0.0910490139652558 no 2998 0.0372855632542986 1053 2987815 SGTC_2669 eugenol 100 µM -1.78414659542858 0.0909181456386367 no 2999 0.0371999237596185 1046 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_616 4092-0450 108 µM -1.78793582954588 0.0904485266049792 no 3000 0.0368931807274268 1061 787165 SGTC_3303 9125618 40.5795 µM -1.78870065137872 0.0903539571933519 no 3001 0.036831519004513 1033 22695467 SGTC_777 1315-0167 517 µM -1.79526011069304 0.089545900577218 no 3002 0.0363061336274366 1029 4221767 SGTC_1742 st038235 28.8875 µM -1.79630577456779 0.089417583950196 no 3003 0.0362229499928197 1041 564103 YBR002C RER2 SGTC_1673 st016611 27.3 µM -1.79896635129568 0.0890917131969691 no 3004 0.0360120017917327 1060 5226799 SGTC_1024 4507-0395 26 µM -1.80153120935137 0.0887784037153827 no 3005 0.0358095963824696 1058 4201836 SGTC_1553 gossypol 38.6 µM -1.80541032827962 0.0883061109796738 no 3006 0.0355052480735451 1042 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_816 0325-0417 81.3 µM -1.80579782585851 0.0882590352133436 no 3007 0.035474962604134 1039 68101 SGTC_2182 6325192 200 µM -1.80629524750938 0.0881986325639912 no 3008 0.0354361168997165 1033 736248 SGTC_1940 st075990 51.1 µM -1.80876669976079 0.0878989772747198 no 3009 0.0352436278733236 1060 1084979 SGTC_2605 digitonin 300 nM -1.81162640203032 0.0875531962950169 no 3010 0.0350219712898196 1053 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2372 9071633 200 µM -1.82242258999153 0.0862569225200507 no 3011 0.0341954447571708 1066 21321366 SGTC_79 0052-0007 94.094 µM -1.82707924448096 0.0857022604413233 no 3012 0.0338439277251522 1035 2801472 SGTC_704 1310-0270 142 µM -1.82945574711896 0.0854202222699568 no 3013 0.033665681442205 1053 5718033 SGTC_3102 9121669 49.47 µM -1.83036152925897 0.0853129091876979 no 3014 0.0335979481683719 1076 41905072 SGTC_1728 st035614 33.7865 µM -1.83538860485624 0.0847191584936504 no 3015 0.03322406545511 1036 15945546 SGTC_2716 st080858 38.6235 µM -1.83565903861391 0.0846873054714622 no 3016 0.0332040497983808 1042 5296050 SGTC_1173 0443-0020 122 µM -1.83568642878571 0.0846840798228748 no 3017 0.0332020231193059 1063 5331295 SGTC_938 3126-1755 342 µM -1.83800472166095 0.0844113960766575 no 3018 0.0330308547772041 1043 1777771 SGTC_1100 amiodarone 5.07 µM -1.84010217168529 0.0841652565948934 no 3019 0.0328766192663735 1049 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_28 pentachloropyridine N-oxide 1.606 µM -1.84129067188404 0.0840260233319225 no 3020 0.0327894869881947 1062 140250 A respiratory chain inhibitor. SGTC_3081 9117243 49.47 µM -1.8485779386805 0.0831760959147323 no 3021 0.0322593903533481 1060 45595589 SGTC_908 3448-7491 47.7 µM -1.84976787351966 0.0830379277534366 no 3022 0.0321735065534348 1006 1203031 SGTC_320 4092-0846 5.34 µM -1.85398975674356 0.0825491003827813 no 3023 0.031870312734578 1050 1359356 SGTC_1098 clofazimine 15.1 µM -1.86178092655437 0.0816526980989156 no 3024 0.0313169880333567 1051 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_3178 9107506 49.47 µM -1.86291050782502 0.0815233471402546 no 3025 0.0312374290958768 1058 8897194 SGTC_2564 betulinic acid 100 µM -1.86311894471425 0.0814994954477463 no 3026 0.0312227667039683 1063 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_1121 fusaric acid 630.51 nM -1.86409350673905 0.081388044924541 no 3027 0.0311542871206479 1052 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_2273 7815444 169.05 µM -1.86608593245796 0.0811605497299262 no 3028 0.0310146719055152 1048 2824616 SGTC_253 dyclonine 31.25 µM -1.86900673204581 0.080827920528796 no 3029 0.0308109388900909 1063 3180 An oral anasthetic. SGTC_540 1187-0821 17.3 µM -1.87165018893412 0.0805277641651084 no 3030 0.0306275075028512 1057 847520 SGTC_496 calpeptin 138 µM -1.88533967663093 0.078986822006505 no 3031 0.0296919963180411 1050 73364 A calpain inhibitor. SGTC_1666 st014829 29 µM -1.88865398529152 0.0786171305867391 no 3032 0.0294691040724982 1071 3858230 SGTC_3165 9101544 49.47 µM -1.89218958268359 0.0782242030014499 no 3033 0.0292328629227739 1067 5002184 SGTC_1 0258-0098 57.368 µM -1.89506162217244 0.0779061175593073 no 3034 0.0290421191403703 1021 6790032 YDR047W HEM12 SGTC_989 1501-0895 10.3 µM -1.89642486982886 0.0777554784764031 no 3035 0.0289519429384943 1047 2830112 SGTC_2618 avocadyne 43.43 µM -1.89870458279639 0.0775040639830017 no 3036 0.0288016643381076 1067 3015189 SGTC_2269 7935389 174.42 µM -1.89875802980328 0.0774981770803045 no 3037 0.0287981489082229 1051 97605 SGTC_1663 st014140 55.4 µM -1.89959571231475 0.0774059551816051 no 3038 0.0287430976723275 1049 4207120 SGTC_1033 k072-0102 21.3 µM -1.90156643989934 0.077189323149711 no 3039 0.0286139294295872 1040 5965931 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -1.90434527894308 0.0768846426746154 no 3040 0.0284326154326407 1049 5024745 SGTC_56 0957-0365 83.25 µM -1.90512238406679 0.0767996022732003 no 3041 0.0283820821751323 1056 6752360 SGTC_1061 3448-9325 110 µM -1.90676086851604 0.0766205335343657 no 3042 0.0282757803986569 1052 723482 SGTC_2451 5856223 45.7 µM -1.90690452200232 0.0766048489059708 no 3043 0.0282664762531 1053 2179896 SGTC_627 1391-0720 175 µM -1.9140887938144 0.0758235540861961 no 3044 0.0278044055710322 1068 997839 SGTC_1390 3413-2614 145 µM -1.91639011374579 0.0755745715310404 no 3045 0.0276577291279446 1068 3421432 SGTC_170 4197-0004 226 µM -1.92044418166475 0.0751374730817313 no 3046 0.0274009086769582 1057 218692 SGTC_141 0443-0274 32.331 µM -1.92375874544247 0.0747815404112815 no 3047 0.027192415360439 934 1627241 SGTC_379 3970-0972 5.9 µM -1.92479925535587 0.0746700715330832 no 3048 0.0271272386028717 1064 2898042 YBL034C STU1 SGTC_2880 9042983 58.44 µM -1.92512907296013 0.074634764953175 no 3049 0.0271066063040947 1071 6464714 SGTC_2075 5212009 200 µM -1.92842312597214 0.0742828392785665 no 3050 0.026901258811789 1054 780898 SGTC_3337 9144342 33.5465 µM -1.92964420202957 0.0741527060028111 no 3051 0.0268254689934674 1060 17682949 SGTC_1236 0330-0013 258 µM -1.93143926417653 0.0739617177772307 no 3052 0.0267143767293983 1066 4617066 SGTC_1880 MG-132 525 µM -1.93170963236503 0.0739329841623551 no 3053 0.0266976776057534 1036 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_3070 9117005 49.47 µM -1.93878032254203 0.0731845651596388 no 3054 0.0262640465812568 1084 8779016 SGTC_278 4092-0821 23.9 µM -1.94586311695586 0.0724406904195296 no 3055 0.0258355922171965 1068 877900 SGTC_3185 9108267 49.47 µM -1.94614961521927 0.0724107231147744 no 3056 0.0258183850918448 1066 4910486 SGTC_297 0986-0032 24 µM -1.94757619215103 0.0722616466027203 no 3057 0.0257328473913554 1050 2847425 SGTC_2512 diallyl trisulfide 49.23 µM -1.95234985732246 0.0717645112544533 no 3058 0.0254483409491466 1074 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_665 3914-0008 307 µM -1.95477332160067 0.0715131347412095 no 3059 0.0253049156939873 1071 1069549 SGTC_252 miconazole 1.30953 nM -1.95524397558464 0.0714643940830862 no 3060 0.0252771401681446 1033 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_3145 9085516 49.47 µM -1.95577353762768 0.0714095834241886 no 3061 0.0252459187423822 1067 25236195 SGTC_33 0986-0033 35.816 µM -1.95799316139322 0.0711801991964144 no 3062 0.0251154075731171 1054 2848082 SGTC_310 1273-0058 1.06 µM -1.95940079950451 0.07103502203173 no 3063 0.0250329335600316 994 2734232 SGTC_3308 9128332 17.569 µM -1.96077022618497 0.0708940041486411 no 3064 0.0249529163665702 1056 17332805 YDL196W YDL196W SGTC_1648 st011736 69.8 µM -1.96194426567149 0.0707732777316967 no 3065 0.0248844867212933 1074 2855514 SGTC_524 r073-0010 27.8 µM -1.9663358793724 0.0703230885457847 no 3066 0.0246299124373616 1063 2772106 SGTC_1808 st050063 61.5 µM -1.96649932883583 0.0703063757625413 no 3067 0.0246204798897218 1059 4011993 SGTC_2838 9002687 71.43 µM -1.97545189500855 0.0693956289533974 no 3068 0.024108444285368 1062 6457060 SGTC_747 3448-8087 38.7 µM -1.97583271859556 0.0693570901172566 no 3069 0.0240868632170457 1075 5168703 SGTC_383 2324-0395 7.37 µM -1.97623611289793 0.069316285137392 no 3070 0.0240640207822409 996 3146421 SGTC_2706 st078239 82.5 µM -1.98452500379103 0.0684819179581074 no 3071 0.0235986717625058 1065 15434492 SGTC_1497 4476-2978 41.3 µM -1.98586363518316 0.0683478998475977 no 3072 0.0235242337698721 1061 1528379 SGTC_465 cgp-37157 41 µM -1.98877951577891 0.0680566748377247 no 3073 0.0233627723651872 1072 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_376 3970-0862 59.1 µM -1.99158355902901 0.0677775241229742 no 3074 0.023208384377695 1055 3135186 SGTC_726 3448-4391 34.2 µM -2.00084407734985 0.0668618932809508 no 3075 0.0227045978467755 1065 1356692 SGTC_2326 6164455 177.58 µM -2.00437640494109 0.0665151676087907 no 3076 0.0225148774390976 1059 2888790 SGTC_713 1488-1073 324 µM -2.00550348494402 0.0664048292661486 no 3077 0.0224546242781863 1069 3312542 SGTC_365 0121-0052 13.6 µM -2.0102065164545 0.0659459430042359 no 3078 0.0222046680061513 1037 3101739 SGTC_1501 4491-0275 38.4 µM -2.01089184750316 0.0658792792059102 no 3079 0.0221684408312899 1071 5104718 SGTC_3060 1327-0027 12.5 µM -2.01798014704853 0.0651928433117282 no 3080 0.0217966644948441 1040 16000455 YPR107C YTH1 SGTC_2944 9067346 25.62 µM -2.01935730333609 0.0650601246954221 no 3081 0.0217250479593733 1059 6473075 SGTC_2635 hydroquinidine 100 µM -2.01968881287451 0.0650282079598766 no 3082 0.0217078381183534 1064 442912 An experimental heart treatment. SGTC_3006 9075424 71.4286 µM -2.02802444778911 0.064229666273348 no 3083 0.0212788764487274 1064 7465181 SGTC_2493 resveratrol 26.09 µM -2.03127842533476 0.0639200163222196 no 3084 0.0211133793352728 1063 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_2678 equilin 100 µM -2.03343374937972 0.0637155547123085 no 3085 0.0210043602675749 1058 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_1929 genistein trimethyl ether 50.5 µM -2.03748625111998 0.0633324982513019 no 3086 0.0208006691749661 1048 136420 SGTC_229 benomyl 22.8748 µM -2.03919314771879 0.0631716940683015 no 3087 0.0207153772630421 1067 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_333 3486-0131 40.1 µM -2.03988089030406 0.0631069927952039 no 3088 0.0206810952600723 1060 6744690 SGTC_758 0868-0029 16 µM -2.04098867977458 0.0630028829882952 no 3089 0.020625976153751 1050 762687 SGTC_3295 9122362 53.5725 µM -2.04227028415595 0.0628826050687774 no 3090 0.0205623640216926 1075 4730473 SGTC_2007 4011539 71.82 µM -2.04282620755106 0.062830487604498 no 3091 0.0205348226211876 1053 45595301 SGTC_411 enrofloxacin 100 µM -2.04815467593222 0.0623326529136228 no 3092 0.0202724229568999 1052 71188 A bacterial gyrase inhibitor. SGTC_1321 1326-2144 215 µM -2.05786792856804 0.0614330722007109 no 3093 0.0198014065704 1066 3513030 SGTC_1748 st037455 53.6035 µM -2.05951052767078 0.0612819524318283 no 3094 0.019722678777193 1067 580690 SGTC_2947 9072639 7.68 µM -2.06042012216232 0.0611983944168697 no 3095 0.0196791974365567 1074 16488146 SGTC_43 0570-0105 72.5 µM -2.06090610857565 0.0611537867870476 no 3096 0.0196559992078105 1063 1114046 YDL195W SEC31 SGTC_207 4185-0010 4.486 µM -2.06407574296198 0.060863476003701 no 3097 0.0195052677325627 1058 3761753 SGTC_1212 0520-0165 585 µM -2.06515096797344 0.0607652399466884 no 3098 0.0194543590901156 1070 5403258 SGTC_1957 st077035 62.4 µM -2.06584531493824 0.0607018680685691 no 3099 0.0194215438832771 1073 705593 SGTC_2510 benzyl isothiocyanate 8.31 µM -2.06599479069391 0.060688232432167 no 3100 0.0194144857341925 1046 2346 DNA damaging agent; causes G2/M arrest. SGTC_547 1120-0019 610 nM -2.0709992151032 0.0602330948307577 no 3101 0.0191794347029898 1019 3676939 SGTC_807 1315-0151 48 µM -2.07215531178975 0.0601283321368191 no 3102 0.0191254797143377 1075 4011080 SGTC_537 1334-0398 209 µM -2.07484863472157 0.0598848230284805 no 3103 0.0190002827454282 1064 5846986 SGTC_3302 9125395 16.351 µM -2.08533064023945 0.0589444685776224 no 3104 0.0185196489921002 1059 17599668 SGTC_1565 sinapyl alcohol 95.1 µM -2.10002269295358 0.0576459718543273 no 3105 0.0178634224688973 1045 5280507 A phenol propionate derived from cinnamic acid. SGTC_3179 9107801 49.47 µM -2.10075119454127 0.0575821763253849 no 3106 0.017831406375644 1067 4818259 SGTC_283 0987-0079 11.7 µM -2.10154758993605 0.0575124988216035 no 3107 0.0177964625090499 1072 411556 SGTC_853 0419-0306 21 µM -2.11137077958869 0.0566585010305811 no 3108 0.0173702273126196 1078 762713 SGTC_874 0599-0792 117 µM -2.11894721454572 0.0560066785562628 no 3109 0.017047464079583 1063 765305 SGTC_231 b-estradiol 524 µM -2.11924155214802 0.0559814757014302 no 3110 0.0170350291627101 1074 450 A steroid. SGTC_2988 9073640 71.4286 µM -2.1249958595414 0.05549055403238 no 3111 0.0167934791932211 1069 9102229 SGTC_2691 st077356 60.2 µM -2.12792210996788 0.0552422115395094 no 3112 0.0166717710413628 1076 2839272 SGTC_63 0099-0242 26.702 µM -2.12940182257037 0.0551169671834538 no 3113 0.0166105149027888 1073 3898502 YLR359W ADE13 SGTC_1729 st035615 45.989 µM -2.1311043595766 0.0549731404024269 no 3114 0.0165402728234467 1054 17385451 SGTC_2076 5212012 200 µM -2.1321441122872 0.0548854502301323 no 3115 0.0164975006015655 1064 604802 SGTC_2225 6654152 15.4 µM -2.13285302646987 0.054825725570959 no 3116 0.0164683923717381 1059 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_745 0469-0705 296 µM -2.13429636548029 0.0547042858024665 no 3117 0.0164092643029353 1072 3486736 SGTC_2287 7945887 168.79 µM -2.13525168180753 0.0546240243537016 no 3118 0.016370228702774 1072 1245853 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -2.1441047814015 0.0538846486003398 no 3119 0.0160122460253694 1063 23847180 SGTC_2271 7849410 118.62 µM -2.14707986261615 0.0536379681463095 no 3120 0.0158934620861191 1069 972430 SGTC_2211 7117706 200 µM -2.15810015955484 0.0527319998602795 no 3121 0.0154600226819172 1067 822771 SGTC_163 TUB2.036 7.546 µM -2.16021954612006 0.0525591671279653 no 3122 0.0153778388585331 1048 15992207 YJR013W GPI14 SGTC_1383 3049-0032 20.7 µM -2.16774019803466 0.0519494953171643 no 3123 0.0150892295769571 1066 712864 SGTC_3345 9148410 3.559 µM -2.16775454762172 0.0519483374427345 no 3124 0.0150886833833115 1050 4903596 SGTC_2117 5521686 200 µM -2.17330064133979 0.0515023541096056 no 3125 0.014878848630767 1072 803312 SGTC_2256 7954252 200 µM -2.17811202407024 0.0511179230705839 no 3126 0.0146988488133016 1076 2972920 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -2.17944095685327 0.0510121443546643 no 3127 0.0146494631717468 1075 16623 A steroid. SGTC_2744 captopril 92.04 µM -2.1880181880339 0.0503336096425634 no 3128 0.0143341387464163 1076 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_890 0929-0006 47.2 µM -2.18832546350371 0.0503094355442738 no 3129 0.0143229516819416 1078 1378169 SGTC_1477 0139-0234 16 µM -2.1984178598668 0.0495205727996437 no 3130 0.0139596710592311 1078 620880 SGTC_1166 k206-0078 225 µM -2.20102638565755 0.0493182937052362 no 3131 0.0138670779841161 1073 5404595 SGTC_1407 3909-7909 12.3 µM -2.20708877524398 0.0488507314754107 no 3132 0.0136539289124034 1050 4411780 SGTC_1611 st001856 99.4 µM -2.21162788964112 0.0485029763335934 no 3133 0.0134961933644661 1082 647478 SGTC_921 1561-0023 372 µM -2.23240458029351 0.046936405545137 no 3134 0.0127941176849138 1069 24050882 SGTC_662 k832-1615 104 µM -2.23255360691107 0.0469253172269538 no 3135 0.0127891981945029 1078 5878478 SGTC_2006 4011487 200 µM -2.23637412546424 0.0466417683333202 no 3136 0.0126636372882294 1070 45595294 SGTC_2427 5545055 42.75 µM -2.23916785998972 0.0464352961853762 no 3137 0.0125724981088788 1064 5372858 SGTC_306 1672-3436 11.6 µM -2.24340796820901 0.0461233316239694 no 3138 0.0124352592648329 1081 6797378 SGTC_720 r052-1644 49.9 µM -2.24728698063204 0.0458394111065121 no 3139 0.0123108461959292 1078 1422863 YOR257W CDC31 SGTC_2139 5578692 56.4705 µM -2.26496776023927 0.0445630280851442 no 3140 0.0117573290020859 1047 650991 YMR113W FOL3 SGTC_628 1636-0253 16 µM -2.28145991869252 0.0433984091116454 no 3141 0.0112606229446033 1062 4456143 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -2.28179645656459 0.0433749022867356 no 3142 0.01125068004605 1077 6710655 SGTC_1301 naphtanilide LB 4.81 µM -2.28445807910435 0.0431893526342752 no 3143 0.0111723117982416 1065 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_821 1114-0266 29.2 µM -2.28964140003604 0.0428298479033104 no 3144 0.0110210564913123 1077 3123235 SGTC_1660 st012960 28.1 µM -2.29298687298746 0.0425990996240623 no 3145 0.0109243803574681 1075 24207266 SGTC_2114 5491910 81.25 µM -2.29358448602068 0.042557986297467 no 3146 0.0109071886805066 1077 2849228 SGTC_830 4076-0286 57.8 µM -2.29715611053499 0.0423129416337799 no 3147 0.0108049329180481 1080 6866659 SGTC_553 k007-0256 45.7 µM -2.30256823638375 0.0419437990700677 no 3148 0.0106515740165199 1083 6287000 SGTC_3022 9087993 49.47 µM -2.30403499236351 0.0418442069757189 no 3149 0.0106103396884916 1089 17173644 SGTC_705 1124-0212 310 µM -2.30589612919366 0.0417181123174371 no 3150 0.0105582184898318 1070 9554485 SGTC_1381 2324-0066 62.1 µM -2.30839649275098 0.0415491937931172 no 3151 0.0104885469461408 1079 10885928 SGTC_1883 5-benzylidenerhodanine 20 µM -2.31164378133578 0.0413306424466849 no 3152 0.0103986609191778 1064 1273210 SGTC_818 4072-2707 53.5 µM -2.31698018528833 0.0409735125485165 no 3153 0.0102524055869136 1065 882871 SGTC_395 anisomycin 6.25 µM -2.31953645553212 0.0408033272824131 no 3154 0.0101829834094254 1084 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_1560 lithocholic acid 53.1 µM -2.32049631577228 0.0407395722925503 no 3155 0.0101570219966687 1065 9903 A bile acid which acts as a detergent. SGTC_2310 7668677 200 µM -2.32441913740688 0.0404798538678088 no 3156 0.0100515204285226 1072 2197143 SGTC_1179 1021-1431 9.29 µM -2.32620495678922 0.0403620661300931 no 3157 0.0100038096841782 1083 2840958 SGTC_204 PMA1.184 62.41 µM -2.33572399867678 0.0397389037963304 no 3158 0.00975281544499691 1086 2252213 YGL008C PMA1 SGTC_2231 micatex 6.853 µM -2.34253017507329 0.0392981526195341 no 3159 0.00957674254641355 1085 20737 An antifungal of unknown mechanism. SGTC_2432 5630864 12.22 µM -2.34786760945762 0.0389553034789509 no 3160 0.00944061554958096 1079 5714970 SGTC_2228 7354201 200 µM -2.35365164481466 0.0385865209585943 no 3161 0.00929501174869917 1090 753451 SGTC_1240 0356-0016 42.1 µM -2.36714106247543 0.0377375010527194 no 3162 0.00896304944037953 1036 4305613 SGTC_1453 4237-0541 195 µM -2.37480521384951 0.0372619543281368 no 3163 0.00877910660398655 1061 739892 SGTC_2056 5235370 200 µM -2.37989041363641 0.0369491372549374 no 3164 0.00865889365291073 1069 5511916 SGTC_1649 st011737 51.3 µM -2.38217651990928 0.0368092081892586 no 3165 0.0086053226661102 1054 1761035 SGTC_701 4424-0219 185 µM -2.38582111855646 0.0365870242384117 no 3166 0.00852051886198824 1077 2911779 SGTC_3296 9122258 64.045 µM -2.38947718699249 0.0363652446371419 no 3167 0.00843618584087815 1066 4730474 SGTC_2017 5132927 60.65 µM -2.3895479971769 0.0363609601290877 no 3168 0.00843455974968823 1074 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_760 0568-0725 82.9 µM -2.39856742728944 0.0358185905275607 no 3169 0.00822967292122305 1075 3916171 SGTC_1404 3909-7820 48.3 µM -2.39896191734428 0.0357950205992441 no 3170 0.00822081227719405 1046 23741373 SGTC_1942 st076330 65.2 µM -2.39995601401646 0.0357356818318197 no 3171 0.00819852102203231 1068 24208414 SGTC_50 0929-0078 56.389 µM -2.40855344400697 0.0352258477002213 no 3172 0.0080079405772232 1067 1377751 SGTC_866 0495-0101 262 µM -2.41321603877205 0.0349518573281777 no 3173 0.00790622193457058 1060 635694 SGTC_1249 0481-0015 10.2 µM -2.41710321627901 0.034724772437093 no 3174 0.00782229009019504 1067 4227577 SGTC_1552 6-methylflavone 10.6 µM -2.41947886396387 0.0345865870174254 no 3175 0.00777138198145209 1084 689013 SGTC_2645 abamectin 100 µM -2.41971560347792 0.0345728412619267 no 3176 0.00776632486458768 1017 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_3353 9151644 39.2805 µM -2.4292441037924 0.0340233042401324 no 3177 0.00756517076885105 1082 4909158 SGTC_649 1123-0311 367 µM -2.4298323825684 0.0339896132272401 no 3178 0.00755290350247905 1072 693629 YIL048W NEO1 SGTC_1522 st012842 45.6 µM -2.43275326335051 0.0338227390319365 no 3179 0.00749225400773755 1030 3491067 YOR116C RPO31 SGTC_2001 4023502 57.655 µM -2.43358220999214 0.0337755030716635 no 3180 0.00747512000799347 1073 108941 YCR052W RSC6 SGTC_2021 4019055 173 µM -2.43675914731234 0.0335949736485562 no 3181 0.00740977321740013 1070 44827708 YER133W GLC7 SGTC_763 3453-1109 128 µM -2.45389408447395 0.0326349254056161 no 3182 0.0070659299204179 1086 1560353 SGTC_794 k038-0031 316 µM -2.46242175792729 0.0321656296831888 no 3183 0.00690011397385072 1080 6624242 SGTC_137 0438-0332 85.389 µM -2.46255335683229 0.0321584313997348 no 3184 0.00689758225696512 1068 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_1219 1469-0211 33.1 µM -2.46451461705178 0.0320513105979279 no 3185 0.00685994836819528 1070 6822282 SGTC_2779 methotrexate 400 µM -2.46715113460965 0.0319077727629673 no 3186 0.00680964302636087 1058 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_1578 josamycin 24.2 µM -2.46790670112314 0.031866736068865 no 3187 0.0067952868547889 1081 5282165 A P450 substrate. SGTC_2249 haloperidol 116.36 µM -2.47566836156411 0.0314476998045481 no 3188 0.00664935218454906 1061 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_271 rotenone 740 µM -2.4760497397061 0.0314272279500026 no 3189 0.00664225346899233 1087 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_2603 homopterocarpin 100 µM -2.48622829066685 0.0308849155379172 no 3190 0.00645525578045685 1076 101795 A weak amylase inhibitor. SGTC_2054 5233173 129 µM -2.49003162793898 0.0306842721476682 no 3191 0.00638658639742765 973 6889 SGTC_208 k072-0098 12.366 µM -2.49689055848596 0.0303251608996919 no 3192 0.00626438085589523 1075 5948901 SGTC_2336 9001819 198.65 µM -2.49890823364689 0.0302201873853022 no 3193 0.00622882827060435 1062 2989602 SGTC_40 0327-0103 19.753 µM -2.50244444452882 0.0300369356323709 no 3194 0.00616694906499194 1065 409036 SGTC_158 k038-0087 26.446 µM -2.50993481389795 0.0296518154109734 no 3195 0.00603767250651188 1073 X158 SGTC_902 1120-0002 2.07 µM -2.51288461636658 0.029501279025697 no 3196 0.00598742466959338 1056 3280475 SGTC_1733 st037357 54.9 µM -2.51761044535745 0.0292614299204676 no 3197 0.0059076959693044 1073 1272339 YGL099W LSG1 SGTC_1797 st048695 56.8 µM -2.52481165790703 0.0288990640560376 no 3198 0.00578801553324823 1071 592262 YIL048W NEO1 SGTC_191 3914-0123 66.505 µM -2.54358201801315 0.0279720359157356 no 3199 0.00548611470791954 1091 3144412 SGTC_2468 5987765 72.9 µM -2.56501286842227 0.0269440290238414 no 3200 0.00515859892760467 1083 26772094 SGTC_2844 9010103 25.97 µM -2.57014561583645 0.0267025557328205 no 3201 0.00508278876336647 1075 2480525 SGTC_3276 9139060 49.47 µM -2.57947660549603 0.0262682029889048 no 3202 0.00494750803034085 1089 4870619 SGTC_1475 4092-1048 11.7 µM -2.58417867490893 0.0260515719896402 no 3203 0.00488056059958337 1089 2881759 SGTC_3339 9145883 14.936 µM -2.58500253467805 0.0260137698687218 no 3204 0.00486891407679255 1058 2030670 SGTC_3170 9103054 49.47 µM -2.58607571033597 0.025964596916646 no 3205 0.00485378024279889 1068 16432970 SGTC_1136 pergolide 1.05886 µM -2.58997742165406 0.0257864751392649 no 3206 0.00479911134983759 1083 47811 A dopamine receptor agonist. SGTC_435 c-PAF 6.7 µM -2.59666578198461 0.0254835159553034 no 3207 0.00470667339106126 1071 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_1244 0416-0015 52.5 µM -2.60263449869608 0.0252156766016823 no 3208 0.00462552602667027 1088 96201 SGTC_1603 st002045 67.8 µM -2.60464475128333 0.0251260015216483 no 3209 0.00459847815151027 1087 5887985 SGTC_1143 3454-2408 5.08 µM -2.60850700018593 0.0249544610212741 no 3210 0.00454690758567309 1068 X1143 SGTC_2332 7982454 138.89 µM -2.61957806014197 0.0244681768318718 no 3211 0.00440193105767514 1087 2981748 SGTC_1664 st014217 9.02 µM -2.62822917429261 0.0240937447434601 no 3212 0.00429153348830486 1075 3982782 SGTC_246 cycloheximide 667 µM -2.6390089688986 0.0236339278054678 no 3213 0.00415743905321478 1087 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_462 ag-879 158 µM -2.65553258552634 0.0229434447545372 no 3214 0.00395916414814439 1083 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_3207 9114163 49.47 µM -2.66207559818634 0.0226747638933129 no 3215 0.0038830217167743 1080 849233 SGTC_2928 9011484 9.79 µM -2.7007544676409 0.0211400815814433 no 3216 0.0034591195482013 1061 2994751 SGTC_1671 st016596 74.5 µM -2.70353674750785 0.0210331590851604 no 3217 0.00343029307931301 1094 2829167 SGTC_2766 oltipraz 83.91 µM -2.71111036759095 0.0207444220156724 no 3218 0.00335291507035158 1031 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_2179 6298986 200 µM -2.71667088520482 0.0205345755224774 no 3219 0.00329710719582342 1054 738374 SGTC_2734 clemastine 41.6 µM -2.72242182730076 0.0203194373506129 no 3220 0.00324026817637745 1095 26987 Clemastine is a selective histamine H1 antagonist. SGTC_2404 5161160 200 µM -2.72272609396661 0.0203081083933525 no 3221 0.00323728567745662 1076 2831543 SGTC_398 bronopol 33.3 µM -2.72368144866585 0.0202725718484397 no 3222 0.00322793709236206 1084 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_2607 solasodine 47.35 µM -2.732704931835 0.0199395162032843 no 3223 0.00314082898304983 1086 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_1230 0170-0365 3.77 µM -2.746093644048 0.0194539017362024 no 3224 0.00301547732193065 1073 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_1057 3448-5381 134 µM -2.74684603977359 0.0194269127851376 no 3225 0.00300856866162587 1069 5497911 SGTC_1506 4226-2149 212 µM -2.7476296653313 0.019398837422354 no 3226 0.00300138840570231 1088 991114 SGTC_31 0508-1974 57.237 µM -2.75399515277309 0.0191720525285704 no 3227 0.00294363200438562 1087 6810525 SGTC_116 0155-0182 31.788 µM -2.76296639814185 0.0188562609137908 no 3228 0.00286393314147085 979 771486 SGTC_476 mead acid 10 µM -2.77160884836398 0.0185562389299129 no 3229 0.00278900097896854 1092 5312531 An omega 9 fatty acid. SGTC_2065 5221596 34.26 µM -2.78669793438946 0.018042162826708 no 3230 0.00266240440517677 1084 788581 SGTC_1010 4112-3296 15.2 µM -2.78736472316052 0.0180197286752997 no 3231 0.0026569317544694 1075 704384 SGTC_601 0986-0029 62.9 µM -2.78754333315048 0.0180137233707947 no 3232 0.00265546754410322 1081 24747981 SGTC_86 0417-1630 471.922 µM -2.79240875562145 0.0178507910849534 no 3233 0.00261586102123086 1085 3634867 SGTC_1081 sertraline 6 µM -2.81615715387852 0.0170734358680026 no 3234 0.00243009430418066 1082 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_3126 9127922 49.47 µM -2.82847533923755 0.0166817486087307 no 3235 0.00233851521690933 1071 45595682 SGTC_1482 3346-2049 8.48 µM -2.82923862526354 0.0166577330663203 no 3236 0.00233294475178872 1088 3826804 SGTC_2813 7971799 71.43 µM -2.84273704301038 0.016237890003807 no 3237 0.00223639782379746 1090 2234054 SGTC_2131 toluylene red 5.2905 µM -2.85294830437156 0.0159263402824251 no 3238 0.00216578336972124 1085 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_463 ikarugamyin 104 µM -2.85562486729251 0.0158455300293614 no 3239 0.00214761147051276 1094 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_3027 9089541 49.47 µM -2.87031682512114 0.0154081881300395 no 3240 0.00205030352029124 1089 9943819 SGTC_1886 st057356 49.9 µM -2.88050942350466 0.0151109051781898 no 3241 0.00198516541602655 1092 24207747 SGTC_2640 pentamidine 10.38 µM -2.88600410068595 0.0149526987366473 no 3242 0.00195083536801905 1049 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1206 3978-0017 132 µM -2.90132190097022 0.0145191552755135 no 3243 0.00185795970733522 1076 3873677 SGTC_293 4049-0273 38.5 µM -2.90745652749489 0.0143485841796324 no 3244 0.0018219049344466 1083 1380311 SGTC_1831 st055328 12 µM -2.9222212781206 0.0139451149061529 no 3245 0.00173772264622229 1083 1103068 SGTC_3343 9148379 18.9835 µM -2.92585146251478 0.0138474258916653 no 3246 0.00171757454628097 1082 1955036 SGTC_119 0121-0043 24.815 µM -2.94314474727694 0.0133901210178851 no 3247 0.00162448235717105 1086 1092378 SGTC_3154 9100113 49.47 µM -2.9434476471805 0.0133822287367025 no 3248 0.00162289357523701 1090 25237525 SGTC_1036 k216-0215 33.5 µM -2.96036199532868 0.0129478416336673 no 3249 0.0015363887735633 1033 622330 SGTC_2541 muurolladie-3-one 83.07 µM -2.96167495692329 0.012914638496244 no 3250 0.00152985302138438 1070 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_2338 7999974 200 µM -2.9687032171889 0.0127381518940608 no 3251 0.00149529641220545 1077 315925 SGTC_1597 7-benzyloxygramine 47.5 µM -2.97189319921806 0.0126587392486797 no 3252 0.0014798481020387 1076 260807 SGTC_150 3970-0969 77.2 µM -2.97341296157052 0.0126210566237456 no 3253 0.00147253960018978 1088 6615640 SGTC_298 1391-0729 10 µM -2.98814082344153 0.012260879628653 no 3254 0.00140340096932504 1089 3237558 SGTC_1476 4112-3294 3.34 µM -2.99009976900547 0.0122136502592242 no 3255 0.00139443169930358 1075 704369 SGTC_2649 anisomycin 9.56 µM -2.99359054318446 0.0121298798562412 no 3256 0.00137857843223666 1091 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_212 3807-4682 38.772 µM -3.00764746477754 0.0117975678784503 no 3257 0.00131639178192448 1094 3125501 YBL034C STU1 SGTC_1262 0737-0114 49.6 µM -3.0087575730658 0.0117716642320533 no 3258 0.00131159169738946 1091 765919 SGTC_1605 st000082 49.1 µM -3.0191161680761 0.0115323228693611 no 3259 0.001267566516294 1081 1114022 SGTC_842 0271-0008 11.1 µM -3.03697712790305 0.0111295531738728 no 3260 0.00119481793597606 1085 1221709 SGTC_2913 7966556 36.57 µM -3.04280321262425 0.0110008462042805 no 3261 0.00117192776787929 1071 2976516 SGTC_2230 bromochlorosalicylanilide 954.5 nM -3.04532838504321 0.0109454648145146 no 3262 0.00116213190644991 1083 77254 SGTC_2258 7960471 200 µM -3.04622285910544 0.0109259057220971 no 3263 0.00115868001240719 1093 2974708 SGTC_372 0155-0182 15.9 µM -3.05076252159668 0.010827106986386 no 3264 0.00114130518090441 983 771486 SGTC_49 0717-0965 32.132 µM -3.05138879004723 0.0108135384465244 no 3265 0.00113892706297774 1086 5889349 YGL099W LSG1 SGTC_2910 7948405 25.97 µM -3.05208523084335 0.0107984669589007 no 3266 0.00113628781232831 1086 2971328 SGTC_895 0964-0006 13.7 µM -3.05540092853401 0.0107269633462987 no 3267 0.00112379922482796 1090 6738897 SGTC_344 k064-0035 6.43 µM -3.0987961350433 0.00982846500234272 no 3268 0.000971543368969973 1075 5088750 SGTC_1092 toremifene 6.32 µM -3.11586409678238 0.00949350712395845 no 3269 0.000917033885092507 1092 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_1789 tunicamycin 25 nM -3.12296125123362 0.00935719094108377 no 3270 0.000895206589544032 1081 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2367 9070478 135.38 µM -3.12979659784421 0.00922752518663884 no 3271 0.000874636903987351 1088 572802 SGTC_2353 9059630 146.67 µM -3.13764791472903 0.00908052957162097 no 3272 0.000851546593179195 1088 4779114 SGTC_149 3970-0822 46.1 µM -3.14197466787759 0.00900040193318692 no 3273 0.000839062770834859 1090 3114250 YBL034C STU1 SGTC_2651 TUB2.036 5 µM -3.14761598011615 0.00889686039809221 no 3274 0.000823038949898061 1079 15992207 YFL037W TUB2 SGTC_748 act1.228 77.9 µM -3.15300997755406 0.00879883574198113 no 3275 0.000807981417127458 1090 4421505 YNR035C ARC35 SGTC_2575 plumbagin 510 nM -3.15430125393573 0.00877551040660455 no 3276 0.000804414589188664 1085 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1347 1493-0251 600 nM -3.16957983468713 0.00850360957515819 no 3277 0.000763297568915406 1047 3986378 SGTC_2965 9082772 38.63 µM -3.20011577939153 0.00798225502672429 no 3278 0.000686861960762243 992 16459634 SGTC_143 4032-1194 15.74 µM -3.20864267491819 0.00784178467478416 no 3279 0.000666815611510855 1085 1806963 SGTC_1371 2421-0008 32.7 µM -3.2783958848356 0.00677202429025346 no 3280 0.000521994341924394 1080 2827552 SGTC_2799 7812892 81.82 µM -3.28098972473277 0.0067348598526519 no 3281 0.00051721756327074 1080 20205235 SGTC_501 nsc-95397 161 µM -3.30377460682665 0.00641606764762924 no 3282 0.000476962464828518 1090 262093 SGTC_2646 retinol 96.75 µM -3.31519614575588 0.00626134654016819 no 3283 0.000457894206841694 1091 445354 A vitamin A analog and teratogen. SGTC_1680 diphenhydramine 100 µM -3.31732734533364 0.00623284494939782 no 3284 0.000454415336388841 1083 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_2038 4100038 30.985 µM -3.32052123063988 0.0061903466360339 no 3285 0.000449247624954261 1080 3596803 SGTC_762 1165-0429 115 µM -3.33816086061209 0.0059602225895558 no 3286 0.000421674552544567 1090 5967793 SGTC_2206 7254556 146.969 µM -3.3463900850755 0.00585548414230512 no 3287 0.000409355653961613 1093 4398905 SGTC_645 0845-0943 5.41 µM -3.367713252836 0.00559164920264163 no 3288 0.000378971916612413 1094 1885106 SGTC_312 4092-0653 6.84 µM -3.40564753140921 0.00514828097019735 no 3289 0.000330036692052935 1082 1148278 SGTC_543 3844-1095 191 µM -3.40859765166384 0.00511514891964079 no 3290 0.000326488549118005 1091 4230703 SGTC_990 3985-0011 41.3 µM -3.41082531088669 0.00509025655983768 no 3291 0.000323832860178816 1085 5399565 YGL099W LSG1 SGTC_2756 carbadox 75.1 µM -3.43822094137094 0.00479283342653483 no 3292 0.000292774861508223 1078 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_3316 9136639 10.545 µM -3.43909382400236 0.00478361703587736 no 3293 0.00029183245577582 1092 4903665 SGTC_2286 7945697 125 µM -3.44371483940342 0.00473508850876578 no 3294 0.00028689026370882 1085 1245733 SGTC_2471 5466956 24.79 µM -3.49491764773313 0.00422603781552698 no 3295 0.000237104023409735 1092 724419 SGTC_124 0136-0217 7.121 µM -3.49549364994839 0.00422060102258898 no 3296 0.000236592856002525 1089 3976905 SGTC_255 tunicamycin 200.472 nM -3.49587015004176 0.00421705067984313 no 3297 0.000236259290540411 1084 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2442 5158906 48.48 µM -3.54112433037823 0.00380927617483938 no 3298 0.00019921289213418 1093 1893835 SGTC_2896 9052656 71.43 µM -3.54849406780542 0.00374632433923058 no 3299 0.000193720362786357 1078 6469436 SGTC_893 0958-0369 48.9 µM -3.56618328008893 0.00359901496934048 no 3300 0.00018110904752003 1085 6819948 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -3.5710576074054 0.00355934757935385 no 3301 0.000177771338879532 1094 1241132 A phosphatase inhibitor. SGTC_1941 st076221 61.8 µM -3.5949299213371 0.00337068626976441 no 3302 0.000162239453508256 1086 2828568 SGTC_2925 9010536 32.5 µM -3.64214925793821 0.00302376847153842 no 3303 0.000135185611887572 1050 2994177 SGTC_623 k072-0108 16.9 µM -3.74480302007664 0.00237809821088266 no 3304 9.02676819182467e-05 1093 5382803 SGTC_1785 bathophenanthroline 24 µM -3.75447345181063 0.00232421956032119 no 3305 8.68531270511689e-05 1070 72812 An iron chelator. SGTC_1619 st003326 88.7 µM -3.76106565552757 0.00228812732818544 no 3306 8.45955047276241e-05 1082 2849032 SGTC_3319 9138450 16.7555 µM -3.79649079359523 0.0021027258583201 no 3307 7.33794051469473e-05 1094 2029690 SGTC_1289 0976-0073 69.1 µM -3.81885067065706 0.00199282983021499 no 3308 6.70374451640385e-05 1094 3391136 SGTC_2129 girgensonine 121.053 µM -3.86856690402153 0.00176693723518156 no 3309 5.47384494477726e-05 1091 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1283 0922-0125 16.4 µM -3.87047627593146 0.00175874572633104 no 3310 5.43114640460196e-05 1093 3360884 SGTC_1855 st056195 39.6 µM -3.87353067783856 0.00174571368424885 no 3311 5.36349482480833e-05 1090 4028379 SGTC_1113 artemisinin 1.17947 µM -3.90967427407858 0.00159803679513686 no 3312 4.62103293180999e-05 1087 2240 An anti-malaria and mitochondrial poison. SGTC_966 1300-0360 30.2 µM -3.934700282716 0.00150255484854089 no 3313 4.16502903775636e-05 1081 70588 SGTC_2688 kanamycin b 96.69 µM -3.94885441777937 0.00145088543683541 no 3314 3.92630439806411e-05 1081 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_922 1866-0035 480 µM -3.99798635528881 0.00128386443111508 no 3315 3.19418163962e-05 1087 3156169 SGTC_308 4092-1169 104 µM -4.01564905813739 0.00122825283221322 no 3316 2.96412080376004e-05 1095 2268590 YDL196W YDL196W SGTC_3032 9089427 49.47 µM -4.03795326803517 0.00116117832134892 no 3317 2.6959795445141e-05 1078 17173707 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -4.09772724680376 0.000997623949292985 yes 3318 2.08613245952871e-05 1088 1377 SGTC_778 3456-2434 196 µM -4.09994734562475 0.000991977925482983 yes 3319 2.06622074367e-05 1033 5539063 SGTC_2456 5770359 74.46 µM -4.12966300310498 0.000919177971721109 yes 3320 1.81647677093135e-05 1094 3118787 SGTC_2413 inermin 26.06 µM -4.15525346526979 0.000860453538591162 yes 3321 1.62463567130058e-05 1089 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_2302 7771753 200 µM -4.20596253871651 0.000754153799186379 yes 3322 1.29986648563663e-05 1089 2203047 SGTC_1285 0929-0069 65.5 µM -4.21477933453499 0.000736955874736291 yes 3323 1.250112632206e-05 1093 1206237 SGTC_393 acivicin 6.25 µM -4.33628048762039 0.000533983907865215 yes 3324 7.24570024096607e-06 1086 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_2454 5-benzylidenerhodanine 10.36 µM -4.3484270595561 0.000516833626925 yes 3325 6.85587028715095e-06 1095 1273210 SGTC_3214 9129694 49.47 µM -4.40185550692445 0.000447278929410191 yes 3326 5.36645141689675e-06 1093 17158655 SGTC_2344 7990960 76.95 µM -4.4563385492548 0.000385369090257347 yes 3327 4.16856677969633e-06 1090 140813 SGTC_2519 cryptotanshinone 88.04 µM -4.48091004490079 0.000360137749696196 yes 3328 3.71627176544501e-06 1092 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_3249 9135183 49.47 µM -4.49406051234109 0.000347273201756447 yes 3329 3.49388786731657e-06 1089 4902779 SGTC_810 3825-7150 143 µM -4.49874234077653 0.000342797204473438 yes 3330 3.41783220987829e-06 1094 22330411 YGL099W LSG1 SGTC_2659 sanguinarine 24.21 µM -4.56453576391082 0.000285310269126264 yes 3331 2.50300429818622e-06 1093 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_1556 plumbagin 1.48 µM -4.59278566464528 0.00026349660764213 yes 3332 2.18684103374059e-06 1085 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1701 st028638 40.4 µM -4.73345730645727 0.000176184372432818 yes 3333 1.10363704355452e-06 1095 3490878 SGTC_674 0498-0004 451 µM -4.74839842861912 0.000168704269533513 yes 3334 1.02516907138172e-06 1089 4231473 SGTC_3063 1327-0034 4 µM -4.75781179711989 0.000164145269511724 yes 3335 9.785141463019e-07 1086 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2066 5222451 176 µM -4.79856426351671 0.000145706520081927 yes 3336 7.99035174129255e-07 1082 2281147 SGTC_2418 pentamidine 31.67 µM -4.95385232772501 9.1766323505848e-05 yes 3337 3.63792160903275e-07 1092 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_70 0141-0289 43.283 µM -4.96692147787711 8.82111465519942e-05 yes 3338 3.40120575462217e-07 1093 352408 SGTC_1264 0783-0040 158 µM -4.97660650316428 8.56605448450463e-05 yes 3339 3.23543395625149e-07 1094 2855798 SGTC_3222 9128301 49.47 µM -5.08039186715278 6.23493459438467e-05 yes 3340 1.88328542921066e-07 1090 4911358 SGTC_2566 crystal violet carbinol 226 nM -5.09858692645424 5.89364294394631e-05 yes 3341 1.71099190929409e-07 1094 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_1353 1498-1206 8.11 µM -5.11321881456831 5.63204805527085e-05 yes 3342 1.58357532018719e-07 1080 6756808 SGTC_36 0335-0881 14.2 µM -5.42426808155749 2.08661659852254e-05 yes 3343 2.90962451524753e-08 1094 23828853 SGTC_852 0418-0143 439 µM -5.86223599155604 4.71045430891403e-06 yes 3344 2.2833767534484e-09 1094 5369229 SGTC_453 enantio-paf c16 10 µM -6.05410702676414 2.37350084152426e-06 yes 3345 7.05993568636158e-10 1094 13871343 A lipid and platelet activating factor SGTC_2980 9014342 25.29 µM -6.13088875239399 1.79385370545473e-06 yes 3346 4.36947495889581e-10 1092 2996599 SGTC_173 1273-0061 2.693 µM -6.68304908008345 2.17479971047396e-07 yes 3347 1.17010576761206e-11 1093 2847414 YPL266W DIM1 SGTC_513 4245-1575 41.7 µM -6.73960928656319 1.7353619129707e-07 yes 3348 7.94065526132043e-12 1095 719745 SGTC_3062 9077494 49.47 µM -8.27825325933859 1.88080127888453e-10 yes 3349 6.24975858198127e-17 1074 16459633