SGTCid condition conc unit RER2|YBR002C.score RER2|YBR002C.strain.pval RER2|YBR002C.strain.significant RER2|YBR002C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_10 0279-0212 42.575 µM 17.5976666849006 3.99853173222011e-41 yes 1 1.28341781743086e-69 1 39851 YBR002C RER2
SGTC_1742 st038235 28.8875 µM 17.2265880536648 1.78049405467904e-39 yes 2 8.38797265489859e-67 1 564103 YBR002C RER2
SGTC_19 0279-0214 38.434 µM 14.7264059137158 2.77597808545772e-29 yes 3 2.18150306257139e-49 1 3566274 YBR002C RER2
SGTC_767 0929-0023 86 µM 13.3482686492531 2.40674226775142e-24 yes 4 6.06169738602673e-41 1 1204563
SGTC_748 act1.228 77.9 µM 13.341581363236 2.53637496913274e-24 yes 5 6.63080903288492e-41 3 4421505 YNR035C ARC35
SGTC_2516 gossypol 71.55 µM 13.1478325918558 1.14654181927887e-23 yes 6 8.75612849667926e-40 1 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2513 baicalein 25.65 µM 12.8982697040944 7.74912341235524e-23 yes 7 2.30158505572909e-38 1 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_520 3584-0023 682 µM 11.7451255199937 3.29958764757163e-19 yes 8 3.74056695364376e-32 1 1340790
SGTC_2225 6654152 15.4 µM 11.6039019654869 8.70444856744233e-19 yes 9 1.96854358855862e-31 7 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_173 1273-0061 2.693 µM 11.2311789675029 1.06497088100489e-17 yes 10 1.43314091676213e-29 4 2847414 YPL266W DIM1
SGTC_1883 5-benzylidenerhodanine 20 µM 10.9943587911936 5.01297929838093e-17 yes 11 2.03397236501059e-28 1 1273210
SGTC_70 0141-0289 43.283 µM 10.7990821594286 1.7545269786822e-16 yes 12 1.73830713747823e-27 3 352408
SGTC_2336 9001819 198.65 µM 10.3258975209498 3.33052827724891e-15 yes 13 2.69065737746322e-25 8 2989602
SGTC_204 PMA1.184 62.41 µM 10.208112946715 6.79084144798436e-15 yes 14 9.11885852918993e-25 2 2252213 YGL008C PMA1
SGTC_1882 5615643 20 µM 9.45322574055006 5.39279509664995e-13 yes 15 1.64273200398123e-21 1 2253075
SGTC_131 0141-0277 33.849 µM 9.43546087959707 5.95379219316089e-13 yes 16 1.94639544684029e-21 1 1547771
SGTC_2233 sulbentine 40.3845 µM 9.41235231255481 6.76990912493728e-13 yes 17 2.42577709926773e-21 10 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_1921 5740136 50 µM 9.30101299966217 1.25168510545375e-12 yes 18 6.95569404238187e-21 1 1774243
SGTC_2231 micatex 6.853 µM 9.2294541359534 1.85094789261564e-12 yes 19 1.36007281498899e-20 1 20737 An antifungal of unknown mechanism.
SGTC_2250 alverine citrate 130 µM 9.1386721802992 3.02746246034757e-12 yes 20 3.16119039705707e-20 10 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_602 3130-1533 38.1 µM 8.84363586418771 1.44951214981532e-11 yes 21 4.63266100663135e-19 2 720941
SGTC_2844 9010103 25.97 µM 8.33080593094629 1.95608366240899e-10 yes 22 4.01469299110114e-17 2 2480525
SGTC_2408 sulbentine 18.36 µM 8.32472696867951 2.01552541193078e-10 yes 23 4.22616661255994e-17 8 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_2743 auranofin 4.32 µM 8.31515762546011 2.11268672479852e-10 yes 24 4.5815200858473e-17 3 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_2016 5121758 140 µM 8.22054818986631 3.35545596321962e-10 yes 25 1.01287533511488e-16 1 2795203
SGTC_503 tyrphostin 8 294 µM 8.11178482641087 5.67484259032547e-10 yes 26 2.49407874656424e-16 3 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_211 3455-0679 143.504 µM 8.10733561840087 5.79730087700708e-10 yes 27 2.5870898592764e-16 1 748649
SGTC_134 0269-0018 6.916 µM 8.10682585789008 5.8114947552461e-10 yes 28 2.59796229069681e-16 5 4378915
SGTC_1371 2421-0008 32.7 µM 8.05362548545361 7.49488534564961e-10 yes 29 4.01884555828498e-16 1 2827552
SGTC_614 0462-0418 107 µM 7.94711283598566 1.24114293124037e-09 yes 30 9.54542559594753e-16 1 5188303
SGTC_186 3455-3465 67.277 µM 7.8758026174586 1.73337833699518e-09 yes 31 1.69281181972541e-15 1 755278
SGTC_2759 disulfiram 3.38 µM 7.65520651475907 4.7820638975187e-09 yes 32 9.65009178747955e-15 4 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1188 1403-0014 4.57 µM 7.4524712655029 1.1855820146996e-08 yes 33 4.5803907183634e-14 3 9614867
SGTC_673 1082-0474 110 µM 7.36902041130414 1.71104496588212e-08 yes 34 8.59431730847352e-14 21 3098046
SGTC_1922 5578187 25 µM 7.14652759743232 4.46245375250104e-08 yes 35 4.45002516346571e-13 1 1350412
SGTC_1723 st034307 2.5525 µM 7.01528141331944 7.75122721541959e-08 yes 36 1.1474329171109e-12 2 867466
SGTC_195 4234-0266 16.654 µM 6.84667359706215 1.55289450410419e-07 yes 37 3.77934546e-12 2 2303354
SGTC_596 1155-0152 116 µM 6.74651431017328 2.32841806406955e-07 yes 38 7.57195687726346e-12 1 280313
SGTC_2344 7990960 76.95 µM 6.73264422587257 2.46164785824377e-07 yes 39 8.33035508560349e-12 15 140813
SGTC_1478 0453-0656 35.7 µM 6.60781925298568 4.04159477166515e-07 yes 40 1.95011226705042e-11 1 5258496
SGTC_2510 benzyl isothiocyanate 8.31 µM 6.59660989651446 4.22376896644355e-07 yes 41 2.10332856474021e-11 6 2346 DNA damaging agent; causes G2/M arrest.
SGTC_2454 5-benzylidenerhodanine 10.36 µM 6.58936664529025 4.34566484304924e-07 yes 42 2.20853382720779e-11 1 1273210
SGTC_1318 1280-3875 124 µM 6.58778349170243 4.37275512106188e-07 yes 43 2.23220504808928e-11 1 373245
SGTC_255 tunicamycin 200.472 nM 6.56721604898027 4.73981792520085e-07 yes 44 2.56323208433563e-11 10 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_691 1548-0686 185 µM 6.52565111295588 5.57425228871217e-07 yes 45 3.38533782257956e-11 3 46495133
SGTC_2598 perillyl alcohol 100 µM 6.50144552403705 6.12352932608944e-07 yes 46 3.97759223789302e-11 1 10819 An apoptosis inducer.
SGTC_576 1073-0113 22.7 µM 6.40364071692901 8.92157651141406e-07 yes 47 7.58574469056882e-11 17 5439563
SGTC_462 ag-879 158 µM 6.25611963180239 1.55770137126506e-06 yes 48 1.97337020858847e-10 1 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_892 0929-0076 29 µM 6.18860855662089 2.00197078981878e-06 yes 49 3.03488005656019e-10 2 5751038
SGTC_101 0490-5701 117.494 µM 6.1820995961246 2.05071226799262e-06 yes 50 3.1627297632799e-10 2 4661669
SGTC_553 k007-0256 45.7 µM 6.15726387502685 2.247348303577e-06 yes 51 3.7006237015867e-10 8 6287000
SGTC_1328 1441-0025 69.2 µM 6.13580136426106 2.43171341487474e-06 yes 52 4.23654874852408e-10 1 4562601
SGTC_2889 9059656 51.95 µM 6.12878148726011 2.49509716487321e-06 yes 53 4.42773234167997e-10 1 3949838
SGTC_192 3455-0609 60.9 µM 6.0234771189024 3.65817522670274e-06 yes 54 8.53546263968757e-10 1 3769639
SGTC_2002 4023503 131 µM 5.9415604461088 4.90505580531594e-06 yes 55 1.41160798016904e-09 3 4736863 YCR052W RSC6
SGTC_1346 1488-2224 62.4 µM 5.93823403549765 4.963426063043e-06 yes 56 1.44054284668403e-09 2 3722427
SGTC_2325 6158266 200 µM 5.90278512430919 5.62811267330819e-06 yes 57 1.78707832885783e-09 2 3623240
SGTC_1052 3253-3998 198 µM 5.86891864000281 6.34188853560777e-06 yes 58 2.19323303933609e-09 1 5450317
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 5.8397422338499 7.02533045903346e-06 yes 59 2.61408245704061e-09 5 279621
SGTC_2232 chlorophetanol 41.5365 µM 5.81301696520416 7.71253308968141e-06 yes 60 3.06784201963971e-09 4 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_161 4065-0411 162.148 µM 5.77932731029934 8.67039640935178e-06 yes 61 3.74999457429602e-09 7 1906281 YLR208W SEC13
SGTC_2337 9009472 200 µM 5.71052101545617 1.09903041280194e-05 yes 62 5.63154137527037e-09 2 5742383
SGTC_1319 1306-0155 43.7 µM 5.69729822459604 1.14991254811749e-05 yes 63 6.08604526318678e-09 3 3122360
SGTC_1635 st007035 42.4 µM 5.6904257419613 1.17723591711815e-05 yes 64 6.33615065797997e-09 7 3716403
SGTC_1680 diphenhydramine 100 µM 5.67034060192329 1.26067509564888e-05 yes 65 7.12569543401144e-09 4 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_2265 7929201 200 µM 5.66482714473408 1.28454557758372e-05 yes 66 7.35864107048433e-09 2 1265108
SGTC_1373 2887-0003 58.5 µM 5.65241546626928 1.33986470928396e-05 yes 67 7.91043061026601e-09 3 776948
SGTC_2122 5258151 111.688 µM 5.63193224605293 1.43614392828331e-05 yes 68 8.91008477349489e-09 3 2173356
SGTC_2029 5175081 200 µM 5.57725738885129 1.7263833752424e-05 yes 69 1.22170103653654e-08 2 1380876
SGTC_2617 dihydrotanshinone i 20.83 µM 5.43168598315578 2.79513840371167e-05 yes 70 2.79120466659376e-08 11 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_2307 7538926 6.34 µM 5.42818513297069 2.82730119707068e-05 yes 71 2.84649856262394e-08 9 96582
SGTC_1627 st003713 25.6 µM 5.42550943919106 2.85211918551094e-05 yes 72 2.88947378252021e-08 2 16195070 YER133W GLC7
SGTC_168 3970-0862 530.542 µM 5.38969796429109 3.20478798846211e-05 yes 73 3.52880987082353e-08 24 3135186
SGTC_1456 k015-0012 13 µM 5.35141905329219 3.62721050157568e-05 yes 74 4.36335863137152e-08 3 2989616
SGTC_2393 9031399 185.94 µM 5.33970658827945 3.76664459857398e-05 yes 75 4.65485645686121e-08 4 1526623 YDL150W RPC53
SGTC_1881 5652484 16 µM 5.33540870245263 3.81906953101676e-05 yes 76 4.7664793085264e-08 2 2255129
SGTC_523 1934-0222 13.7 µM 5.31291685450472 4.10486294618759e-05 yes 77 5.3942135160547e-08 1 1361595
SGTC_2823 7987624 58.44 µM 5.2690133039287 4.72193264994006e-05 yes 78 6.85795123513167e-08 6 2239440
SGTC_1246 0422-0085 105 µM 5.18855815254946 6.0863413140309e-05 yes 79 1.05964291187364e-07 3 264295
SGTC_3091 9116372 49.47 µM 5.13606422626188 7.16853891819076e-05 yes 80 1.40275906731677e-07 6 17169793
SGTC_1260 0700-1617 7.75 µM 5.12254210167677 7.47532773768506e-05 yes 81 1.50721879990984e-07 2 2853078
SGTC_1418 3966-3099 2.4 µM 5.11990762619365 7.53651950357092e-05 yes 82 1.52842675738941e-07 2 740335
SGTC_2842 9000675 19.48 µM 5.09004287865532 8.26397967307352e-05 yes 83 1.78991278098594e-07 5 2989072
SGTC_2361 9034121 116 µM 5.07018648124739 8.7836783801407e-05 yes 84 1.98713049814352e-07 14 6496917
SGTC_180 1486-1293 102.781 µM 5.06062937931756 9.04462984011935e-05 yes 85 2.08937394923924e-07 2 4140536
SGTC_1284 0929-0043 16 µM 5.04121675124698 9.59727967337265e-05 yes 86 2.31290578541336e-07 2 1239883
SGTC_2064 5220758 200 µM 5.03279124626123 9.846885375113e-05 yes 87 2.41694708959023e-07 2 788518
SGTC_1356 1502-0781 85.8 µM 5.00669021991954 0.000106593990711494 yes 88 2.76869684514524e-07 1 567702
SGTC_2709 st078560 56 µM 4.98876090537126 0.000112535635915995 yes 89 3.03839001515116e-07 3 17250903
SGTC_2826 7992541 19.48 µM 4.92289808928215 0.000137137746644124 yes 90 4.26359324863096e-07 1 2985066
SGTC_2664 lyso-paf C-16 73.48 µM 4.90008833064945 0.000146774001654648 yes 91 4.7896788821952e-07 2 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_28 pentachloropyridine N-oxide 1.606 µM 4.85869354474604 0.000165900854385884 yes 92 5.90814318812787e-07 2 140250 A respiratory chain inhibitor.
SGTC_3107 9121808 49.47 µM 4.84378995085795 0.000173340725626581 yes 93 6.369280012395e-07 2 662681
SGTC_2519 cryptotanshinone 88.04 µM 4.73207402675056 0.000239882963518141 yes 94 1.11118665110582e-06 12 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_1722 st034304 3.6505 µM 4.6905189876655 0.000270217502939261 yes 95 1.3625646859454e-06 9 4036148 YLR033W RSC58
SGTC_226 1,3-diallylurea 8.28947 mM 4.68715290250484 0.000272825022423309 yes 96 1.38515996668617e-06 7 74537 YKL182W FAS1
SGTC_876 0720-0963 56.8 µM 4.68259763608944 0.000276391071480109 yes 97 1.41631095615994e-06 2 765861
SGTC_2611 pyromycin 23.93 µM 4.66820924152168 0.000287942086793383 yes 98 1.51918190124102e-06 3 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_2326 6164455 177.58 µM 4.64930875744591 0.000303798991646447 yes 99 1.66524664826657e-06 8 2888790
SGTC_1043 0916-0009 19.3 µM 4.63325788049436 0.000317899392536066 yes 100 1.79977844534111e-06 3 3101130
SGTC_2726 cimetidine 79.27 µM 4.63236861022801 0.000318698126091899 yes 101 1.80752880568129e-06 1 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_745 0469-0705 296 µM 4.62414225881718 0.000326175965664843 yes 102 1.88075828106977e-06 10 3486736
SGTC_1332 1480-0653 17.5 µM 4.61727527917915 0.000332542735742025 yes 103 1.94405677970082e-06 1 5749438
SGTC_1622 st003707 19.4 µM 4.61155497451023 0.000337934375744688 yes 104 1.99833962640425e-06 4 10140899
SGTC_177 1327-0068 8.361 µM 4.57804584394478 0.000371185409156121 yes 105 2.34669923920721e-06 16 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_236 1509-0011 5.31 µM 4.5327564454109 0.000420967000011759 yes 106 2.91094647279937e-06 20 3107280
SGTC_2472 5377652 49.4 µM 4.51887498807293 0.00043742321894682 yes 107 3.10845434456888e-06 5 1610903
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 4.51544921102396 0.000441575170938976 yes 108 3.15913443391577e-06 1 1241132 A phosphatase inhibitor.
SGTC_120 rhodamine 6G 52.259 µM 4.50983226081398 0.000448461906626168 yes 109 3.24394525347455e-06 13 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_1063 disulfiram 1.84 µM 4.48081879796584 0.000485646691657213 yes 110 3.71786109644518e-06 5 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_3318 9139014 38.6185 µM 4.44796462988899 0.000531190543695149 yes 111 4.33438998072023e-06 6 16643984
SGTC_1374 2889-5571 141 µM 4.43150234545538 0.0005554684306645 yes 112 4.6789397509825e-06 34 2853281
SGTC_3152 9099253 49.47 µM 4.42468580006446 0.000565818343144618 yes 113 4.82913743119147e-06 21 25236131
SGTC_721 1187-1332 279 µM 4.36985303943003 0.000655790984145449 yes 114 6.21650908864658e-06 9 25730
SGTC_2276 7947513 42.08 µM 4.36101299037334 0.000671475388395723 yes 115 6.47308396600431e-06 3 2105100
SGTC_2669 eugenol 100 µM 4.35609408798695 0.000680351867110263 yes 116 6.62019403934511e-06 1 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_2430 5571206 200 µM 4.34743142636146 0.000696247819501195 yes 117 6.887055749806e-06 16 1731771
SGTC_44 0929-0055 61.211 µM 4.33414175664799 0.000721301130741457 yes 118 7.31649325535283e-06 5 1379590
SGTC_949 1165-0505 146 µM 4.29781254345907 0.000794089539403955 yes 119 8.62459715502533e-06 5 6244267
SGTC_2964 9083345 53.42 µM 4.29774354077223 0.000794234006661552 yes 120 8.62728170778232e-06 10 17741579
SGTC_441 propafenone 146 µM 4.29391289272741 0.000802292090532432 yes 121 8.7775686858878e-06 3 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_2113 5491891 107.031 µM 4.29350254894307 0.000803159730290661 yes 122 8.79381472575921e-06 5 789979
SGTC_1441 4106-0040 13 µM 4.28348210648863 0.000824617092386499 yes 123 9.19954509039511e-06 1 2904180
SGTC_342 k048-0088 23.3 µM 4.2827636111939 0.000826175736479556 yes 124 9.22931224418089e-06 8 6820570
SGTC_1048 3161-0300 24.5 µM 4.22528679830486 0.000960012975662261 yes 125 1.19318330904977e-05 5 2165101
SGTC_676 falcarinol 140 µM 4.21718210772182 0.000980410348544321 yes 126 1.23687097364953e-05 11 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_1695 st026914 34.495 µM 4.2018415302944 0.00102011151507208 no 127 1.32376223202731e-05 3 3289191
SGTC_3154 9100113 49.47 µM 4.17896605103188 0.0010820582876544 no 128 1.46418695294886e-05 9 25237525
SGTC_501 nsc-95397 161 µM 4.16972518818059 0.00110804623096281 no 129 1.52483575965503e-05 6 262093
SGTC_793 0488-0545 106 µM 4.15245489717884 0.00115815428779907 no 130 1.64463798290271e-05 2 292548
SGTC_1274 0865-0114 173 µM 4.15239803453697 0.00115832264308812 no 131 1.64504681425304e-05 6 870624
SGTC_119 0121-0043 24.815 µM 4.14705182936712 0.0011742518346967 no 132 1.68391922401159e-05 18 1092378
SGTC_1998 st075797 76.8 µM 4.10260978971239 0.00131463856968049 no 133 2.04257949076414e-05 1 24208315
SGTC_2043 5101342 149 µM 4.05528837307048 0.001480850970953 no 134 2.5036244642732e-05 5 678451
SGTC_2989 9073649 71.4286 µM 4.04304103350657 0.00152688491906491 no 135 2.63811912332005e-05 6 21367202
SGTC_3252 9135871 49.47 µM 4.0400264790669 0.00153841406259833 no 136 2.67225835541839e-05 6 17682838
SGTC_3104 9120930 49.47 µM 4.03772015028253 0.00154728814081153 no 137 2.69865926567469e-05 1 17014836
SGTC_3178 9107506 49.47 µM 4.01631240953239 0.0016319138749937 no 138 2.95579394604268e-05 8 8897194
SGTC_800 3448-7362 155 µM 4.00088345733336 0.00169549681955006 no 139 3.15532172163594e-05 46 15991913
SGTC_386 1509-0011 3.07 µM 3.99740053544292 0.00171015849408854 no 140 3.20209432912726e-05 6 3107280
SGTC_980 1473-0395 201 µM 3.96542397893352 0.00185025968797643 no 141 3.66328003965614e-05 4 768876
SGTC_864 0469-0573 172 µM 3.94933816089498 0.0019246125003493 no 142 3.91837874234589e-05 5 689425
SGTC_68 0986-0284 82.829 µM 3.94498534049296 0.00194519375834581 no 143 3.990243034e-05 10 423278 YIL048W NEO1
SGTC_2180 6301957 200 µM 3.91921497314766 0.00207119179259539 no 144 4.44189256723827e-05 11 845462
SGTC_832 4083-0019 164 µM 3.91390327839086 0.00209806496440128 no 145 4.54080125154037e-05 28 1990758
SGTC_2710 st078562 53.7235 µM 3.90783754023641 0.00212913958471961 no 146 4.65629442332159e-05 7 17250908
SGTC_534 k292-0788 63.4 µM 3.90768519402909 0.00212992539598559 no 147 4.65923053992781e-05 12 4146317
SGTC_545 4218-0007 221 µM 3.89674320489935 0.00218705747870618 no 148 4.8747449289855e-05 8 2840508
SGTC_622 1348-1566 26.3 µM 3.84982898039078 0.00244808907975081 no 149 5.91001633710929e-05 4 7340407
SGTC_546 peri-Naphthalide 147 µM 3.79866711643075 0.00276460844295126 no 150 7.27381622024925e-05 30 223824 A penicillin ester.
SGTC_2111 5486399 200 µM 3.79849196215094 0.00276575273687793 no 151 7.27895746693667e-05 24 689674
SGTC_1945 st075991 56.6 µM 3.79701125847237 0.0027754433602791 no 152 7.32255702196184e-05 11 1084980
SGTC_2460 5552655 174.22 µM 3.75366994559843 0.00307302158181562 no 153 8.71321446491569e-05 10 5401989
SGTC_2657 nystatin 74.44 µM 3.75246338201119 0.00308170210709997 no 154 8.75527077104627e-05 6 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_3253 9135987 49.47 µM 3.75056608430039 0.00309539672977722 no 155 8.82178980373042e-05 4 4182430
SGTC_986 1493-0483 84 µM 3.69980622739057 0.00348272917048596 no 156 0.000107882073772097 4 40079
SGTC_609 0986-0026 86.3 µM 3.66597346643838 0.0037645294109991 no 157 0.000123199737124285 14 2848610
SGTC_2996 9066192 71.4286 µM 3.64218913080341 0.00397469951032254 no 158 0.000135164668676317 12 6472854
SGTC_1354 1498-1681 81 µM 3.62307405254553 0.0041511613547639 no 159 0.000145561215693253 9 5754243
SGTC_2312 7706453 155.7 µM 3.61905225068218 0.00418916941169146 no 160 0.000147841968944334 16 976098
SGTC_2332 7982454 138.89 µM 3.61346475577946 0.00424249067343676 no 161 0.000151066220098154 12 2981748
SGTC_2075 5212009 200 µM 3.61233084231494 0.00425338535791828 no 162 0.000151728529161302 9 780898
SGTC_269 exalamide 29 µM 3.61141610778328 0.00426219238607297 no 163 0.000152264798246489 7 3316 A derivative of salicylamide.
SGTC_87 0100-0052 35.5 µM 3.59904511354825 0.00438291147447787 no 164 0.000159693892370028 22 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_2154 5570129 200 µM 3.59753392403765 0.00439786548717572 no 165 0.000160624303466018 3 673366
SGTC_1675 st018485 24.5 µM 3.59359477543104 0.00443705993336624 no 166 0.000163073469497837 13 3323024
SGTC_1615 st002656 86.5 µM 3.57800641853122 0.00459524195724976 no 167 0.000173112475685769 5 1584458
SGTC_539 4859-0462 2.54 µM 3.56160376658717 0.00476710328605767 no 168 0.000184298187297041 24 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_3250 9135583 49.47 µM 3.55183597949193 0.00487214856369965 no 169 0.000191276623642237 2 7699353
SGTC_124 0136-0217 7.121 µM 3.54357392746069 0.00496260607656745 no 170 0.000197371311004185 31 3976905
SGTC_2732 terfenadine 20 µM 3.52433085848121 0.00517911442097515 no 171 0.000212276884183801 5 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_611 3453-1652 23.7 µM 3.51789841155545 0.00525333970844061 no 172 0.000217489424252485 30 1560575
SGTC_720 r052-1644 49.9 µM 3.49362946821136 0.00554197575802074 no 173 0.000238250936048321 14 1422863 YOR257W CDC31
SGTC_983 1491-0821 12.2 µM 3.48629366235498 0.00563195244417031 no 174 0.000244881522271687 10 46495113
SGTC_903 1134-0042 114 µM 3.46977490553586 0.00583932641905836 no 175 0.000260447353056009 11 701009
SGTC_2434 5670830 169.91 µM 3.45806761897607 0.00599037193701833 no 176 0.000272032406048583 11 1549830
SGTC_630 4356-0227 183 µM 3.43707161153223 0.00626995373390118 no 177 0.00029402005434105 10 779312
SGTC_2290 7904846 200 µM 3.43525050718312 0.00629473952058537 no 178 0.000296003151667086 23 2962154
SGTC_551 k048-0028 34.9 µM 3.38788170391604 0.00697065748733261 no 179 0.000352173178104174 14 6836383
SGTC_2163 5671233 125 µM 3.38281675376663 0.0070465922950953 no 180 0.000358732436334966 20 701023
SGTC_3198 9112019 49.47 µM 3.38226219471448 0.00705495054079775 no 181 0.000359457459444464 8 45595555
SGTC_88 0180-0332 8.668 µM 3.37010704792558 0.00724036202147416 no 182 0.000375694939365845 12 3101745
SGTC_2936 9038235 15.59 µM 3.36408769479325 0.00733376050483455 no 183 0.000383985684082513 14 4749415
SGTC_1727 st034309 9.9045 µM 3.34722604399783 0.00760106973677808 no 184 0.000408123111436693 24 870305
SGTC_908 3448-7491 47.7 µM 3.34005473147272 0.00771733331121123 no 185 0.000418809402745004 14 1203031
SGTC_3194 9111903 49.47 µM 3.33409736977353 0.00781510320188209 no 186 0.000427883475197392 7 17087251
SGTC_1935 st074532 41.6 µM 3.31676345498611 0.00810580600510508 no 187 0.000455333413694709 13 2829742
SGTC_2911 7942208 15.64 µM 3.28770958453105 0.00861440697938325 no 188 0.00050502987695011 6 1243384
SGTC_2676 harmalol 100 µM 3.28551533526807 0.00865393126618325 no 189 0.000508980004809992 15 5459187 A monoamine oxidase inhibitor
SGTC_2841 9004761 38.96 µM 3.28267554372812 0.00870531954742327 no 190 0.000514134706532357 16 2991039
SGTC_1028 k015-0029 4.8 µM 3.25869013088511 0.00915013477104729 no 191 0.000559639238201989 7 4588309
SGTC_1528 arabinosylhypoxanthine 74.6 µM 3.25117314604014 0.00929357512661494 no 192 0.000574649205326927 14 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_2963 9082507 9 µM 3.24012411348384 0.00950798536698311 no 193 0.000597388412017668 16 16459611
SGTC_100 0086-0128 49.5915 µM 3.2355022204552 0.00959895002578624 no 194 0.000607144704916055 16 93297
SGTC_349 k015-0014 24 µM 3.22977376266746 0.00971274823058919 no 195 0.000619441046942392 15 2196908
SGTC_1060 3448-7350 82 µM 3.22234108903951 0.00986215715423002 no 196 0.000635738368603596 22 570178
SGTC_1382 3002-2117 298 µM 3.22092960485202 0.00989075595746166 no 197 0.000638877644402463 9 1497314
SGTC_825 1988-2224 89.6 µM 3.20414240897356 0.0102364818142662 no 198 0.000677327265073185 13 1180859
SGTC_989 1501-0895 10.3 µM 3.19964242591511 0.0103309300068148 no 199 0.00068799091396495 5 2830112
SGTC_1172 0370-0043 85 µM 3.19785776942326 0.010368597278904 no 200 0.000692262746210159 11 376585
SGTC_2813 7971799 71.43 µM 3.18932923062567 0.01055025989106 no 201 0.00071301682816999 18 2234054
SGTC_1116 jasmonic acid 1.58368 µM 3.18794625167711 0.0105799779210596 no 202 0.000716435841417085 8 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_1985 st071382 65.5 µM 3.18589014899487 0.0106242951124509 no 203 0.000721546901523484 12 6123237
SGTC_2995 9067767 71.4286 µM 3.18469576658497 0.0106501129778389 no 204 0.000724531308072228 8 11673567
SGTC_1197 1601-0112 267 µM 3.1293258495674 0.0119085337260401 no 205 0.000876039476877333 12 7350313
SGTC_2862 9027634 71.43 µM 3.12549671609791 0.0120001433121949 no 206 0.000887525259462339 10 5012562
SGTC_118 0083-0097 135.343 µM 3.11937209721905 0.0121479414786706 no 207 0.000906184633322095 32 5207356
SGTC_850 0388-0143 75.9 µM 3.11596783688608 0.0122307727288147 no 208 0.000916711341156673 5 67273
SGTC_849 0386-0493 241 µM 3.09111032440902 0.01285056561883 no 209 0.000997047640972238 13 726119
SGTC_820 1582-0060 59.9 µM 3.08929823298531 0.0128967920548931 no 210 0.00100314965163916 20 3848840
SGTC_2140 5586273 200 µM 3.06507761618923 0.0135286016610356 no 211 0.00108806757525149 20 854421
SGTC_1247 0448-0043 5.84 µM 3.0591560605045 0.0136870732805247 no 212 0.00110980745645543 20 3089013 YGL099W LSG1
SGTC_816 0325-0417 81.3 µM 3.05746365612198 0.0137326583583902 no 213 0.00111609354093334 13 68101
SGTC_584 0986-0246 15.4 µM 3.05143291631167 0.0138961634045033 no 214 0.00113875967441721 47 53315 YDR232W HEM1
SGTC_1623 st003709 20.3 µM 3.04789195161782 0.0139929458115818 no 215 0.00115226386166759 16 16192618
SGTC_583 1488-1091 88.9 µM 3.04641523940384 0.0140334789913322 no 216 0.00115793881943152 18 4303273
SGTC_262 fenpropimorph 62.5 µM 3.03488488542057 0.0143534613586303 no 217 0.00120313755243247 32 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1939 st074455 53.6 µM 3.03150184768482 0.0144485291375138 no 218 0.00121670215572921 16 1644229
SGTC_2921 7974240 10.71 µM 3.0151462985607 0.0149158236672056 no 219 0.00128427664180508 27 2979074 YDR527W RBA50
SGTC_581 0958-0271 211 µM 3.01410712697277 0.0149459479439776 no 220 0.00128868390473824 11 4591145
SGTC_1362 1611-0397 101 µM 2.99998472251196 0.0153605522621775 no 221 0.00134996574069284 12 27816
SGTC_2543 pimpinellin 60.67 µM 2.99100916500464 0.0156291573544961 no 222 0.00139028573927744 9 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_854 0422-0053 192 µM 2.9901680390662 0.0156545344331152 no 223 0.00139412006272821 21 3596728
SGTC_2058 5236698 133 µM 2.98167260040058 0.0159128327990542 no 224 0.00143339198680969 13 766665
SGTC_593 1203-0218 61.7 µM 2.97329011104087 0.0161712699503291 no 225 0.00147312915959186 15 3666956
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 2.96976435974984 0.0162810406118103 no 226 0.0014901413010365 12 16623 A steroid.
SGTC_2852 9023854 51.95 µM 2.9656478392987 0.0164100112656934 no 227 0.0015102306699934 18 19798528
SGTC_904 1141-0088 396 µM 2.96178038683861 0.0165319745904531 no 228 0.00152932930631767 11 1378119
SGTC_1789 tunicamycin 25 nM 2.95315986425306 0.0168066247520478 no 229 0.0015726951304295 34 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_3335 9143315 29.6265 µM 2.94746660404964 0.0169901442804433 no 230 0.00160194678433398 15 4899691
SGTC_1863 st057641 20.1 µM 2.9407281267589 0.0172095671643745 no 231 0.00163720894955471 15 3921635
SGTC_2682 pyrogallin 40.03 µM 2.92340969102583 0.0177846382043848 no 232 0.00173110320648129 15 822798 An ATP competetive kinase inhibitor.
SGTC_2428 5615643 7.78 µM 2.91384428120828 0.0181092355760773 no 233 0.00178503968949998 23 2253075
SGTC_992 3909-8734 162 µM 2.88122446745135 0.0192544088085286 no 234 0.00198066707598873 9 4288319
SGTC_3292 9120825 59.784 µM 2.87754224268624 0.0193874643375316 no 235 0.00200393123036686 11 24824900
SGTC_1151 3909-8316 15.3 µM 2.87438221785089 0.0195022725122439 no 236 0.00202409364648195 19 800431
SGTC_2565 isoliquiritigenin 100 µM 2.86994218524891 0.0196645605329551 no 237 0.00205273428291407 28 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_2727 riluzole 51.77 µM 2.82227960214597 0.0214800757847859 no 238 0.00238417922772533 21 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_3052 9092717 49.47 µM 2.81020025055591 0.021962069955291 no 239 0.00247553420229697 16 25237534
SGTC_368 fentichlor 4.58 µM 2.80691426986984 0.0220947572726197 no 240 0.00250092757047833 17 7329 A pesticide.
SGTC_708 3448-5400 146 µM 2.80674734313052 0.0221015157652334 no 241 0.00250222380937665 48 3462195
SGTC_1194 1488-0194 225 µM 2.80485807573814 0.0221781297088153 no 242 0.00251693697151289 11 1391452
SGTC_914 3820-6779 408 µM 2.8021890871517 0.0222867449141628 no 243 0.00253785572682772 13 2893481
SGTC_2528 xanthyletin 44.79 µM 2.80053661899642 0.0223542172261865 no 244 0.0025508859384155 20 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_1379 2144-0755 36.5 µM 2.7988633642406 0.0224227137707125 no 245 0.00256414164582062 17 5392327
SGTC_1834 st055981 52.8 µM 2.78871132380627 0.0228421044988032 no 246 0.00264591053316223 30 471719 YDL150W RPC53
SGTC_871 0574-0004 149 µM 2.78824839637434 0.0228613849973738 no 247 0.00264969468535155 43 9551173
SGTC_2187 6125751 200 µM 2.77191685341882 0.0235504053793699 no 248 0.00278636344853619 27 874498
SGTC_449 xestospongin c 11.1929 µM 2.76583648030565 0.0238113574671423 no 249 0.00283884984802623 11 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_1416 3966-0321 25.3 µM 2.74986491269857 0.0245084123955165 no 250 0.00298099188807164 20 582530 YLR208W SEC13
SGTC_2775 cyproheptadine 69.59 µM 2.74058360660917 0.0249212927198354 no 251 0.00306650881801563 17 2913 A selective serotonin reuptake inhibitor.
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 2.74028219204003 0.0249347983839897 no 252 0.00306932269115815 24 688803
SGTC_2890 9046729 58.44 µM 2.7393195748536 0.024977972056417 no 253 0.00307832483801398 41 903329
SGTC_1625 st003711 30.1 µM 2.72718913297989 0.0255274180956965 no 254 0.00319382072129296 15 24207034 YER133W GLC7
SGTC_2034 5197015 53.07 µM 2.72378044257576 0.0256836233356604 no 255 0.00322696978146694 21 780676
SGTC_1552 6-methylflavone 10.6 µM 2.72045308451462 0.0258368723937886 no 256 0.00325962610389806 25 689013
SGTC_525 k781-2675 26.7 µM 2.7025379704645 0.0266752023913792 no 257 0.00344061621769691 67 3651118 YDL195W SEC31
SGTC_1693 xanthone 101.9 µM 2.69409949740163 0.0270778795706316 no 258 0.00352895460599219 26 7020 An insecticide.
SGTC_467 ro 31-8220 72.8 µM 2.69215014818723 0.0271716187332741 no 259 0.00354964878929472 36 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_3043 9092303 49.47 µM 2.68210750854049 0.0276588437075252 no 260 0.0036579972161796 20 25236084
SGTC_2426 5582046 32.21 µM 2.68088103688181 0.0277188426296879 no 261 0.00367143073305614 17 2251934
SGTC_626 0214-0009 33 µM 2.67798068182001 0.0278611594435433 no 262 0.00370337450438486 22 3437874
SGTC_530 4358-1714 28 µM 2.67540032123786 0.0279882857176555 no 263 0.00373200325803704 33 1564641
SGTC_2652 actinonin 100 µM 2.66649540223548 0.0284307190133635 no 264 0.00383233274039408 16 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_1372 2752-0194 270 µM 2.66559760353756 0.0284756465337901 no 265 0.00384258097615826 16 823334
SGTC_1796 st049173 110.4 µM 2.64251810087544 0.029651017420047 no 266 0.0041146033263593 20 94134
SGTC_454 lyso-paf C-16 6.67 µM 2.6386557646378 0.0298515939951029 no 267 0.00416177261548901 21 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_1862 st057513 3.81 µM 2.6198879639245 0.0308423185651255 no 268 0.00439793294334123 28 5393163
SGTC_1791 st048313 56.1 µM 2.61447402794926 0.0311331188558725 no 269 0.00446824772712788 15 1204976
SGTC_2626 ethyl orsellinate 100 µM 2.61346400155817 0.0311876209642851 no 270 0.00448147626490791 39 75653 A natural product.
SGTC_1108 betulinic acid 729.144 nM 2.60911502637988 0.0314231986087377 no 271 0.0045388361443584 21 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_493 zm226600 134 µM 2.60136619471399 0.0318465868921938 no 272 0.0046426639679035 25 5240098 A potassium channel opener. YCR052W RSC6
SGTC_51 1013-0126 23.419 µM 2.59202973783325 0.0323629694834703 no 273 0.00477057619094814 20 1627850
SGTC_1438 4092-1045 4 µM 2.5882882068496 0.03257183687067 no 274 0.00482271206151041 24 1351342
SGTC_1335 1486-0900 202 µM 2.5820739696338 0.0329211967940145 no 275 0.00491042665125934 20 X1335
SGTC_2370 9071495 200 µM 2.57557357385283 0.0332899434822257 no 276 0.00500369900381211 32 21791103
SGTC_754 3474-0146 171 µM 2.57431614527356 0.0333616645813044 no 277 0.00502192256681803 28 24762078
SGTC_3041 9091929 49.47 µM 2.57046286391034 0.0335822404646965 no 278 0.00507813575680571 19 25236887
SGTC_566 0958-0068 16.5 µM 2.56477556977865 0.033909994013707 no 279 0.00516212801655484 39 6815365
SGTC_1484 3473-2379 286 µM 2.56334323459561 0.0339929516474306 no 280 0.00518347526858441 11 671917
SGTC_2224 6650123 117.647 µM 2.55880002760007 0.0342571889257841 no 281 0.0052517070682072 8 2908370
SGTC_1162 k048-0130 20.1 µM 2.55170350254301 0.0346733059374616 no 282 0.00535988504374263 32 6797406
SGTC_1987 st072290 61.9 µM 2.55149363899814 0.0346856745659187 no 283 0.00536311410472328 22 54697379
SGTC_842 0271-0008 11.1 µM 2.55101979487216 0.0347136146198899 no 284 0.00537041125953206 39 1221709
SGTC_2205 7238770 200 µM 2.5484386242116 0.0348661371720781 no 285 0.00541031626603651 16 279867
SGTC_3072 9116419 49.47 µM 2.5434454186167 0.0351627494603256 no 286 0.0054882602301401 24 17170162
SGTC_2264 7948757 110.76 µM 2.5279055124267 0.0360991417415246 no 287 0.00573726141446321 15 2971411
SGTC_3298 9116858 71.43 µM 2.51913377758674 0.036636656555835 no 288 0.00588219750038787 25 2506942
SGTC_2069 5228469 200 µM 2.51171021015498 0.0370966574014929 no 289 0.00600738527442721 27 2835210
SGTC_1629 st005085 44.9 µM 2.51063691828655 0.0371635527529088 no 290 0.00602567887135351 38 24207091
SGTC_130 0136-0219 337.655 µM 2.50831892367487 0.0373083633896596 no 291 0.00606535622683973 32 234244
SGTC_2263 7948595 193.29 µM 2.50191865579401 0.037710598260305 no 292 0.00617611509958013 22 2971371
SGTC_1574 spiramycin 23.7 µM 2.49144922396945 0.0383761920152182 no 293 0.00636115751205054 31 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_1185 1319-0113 81.3 µM 2.48205597145764 0.038981489442309 no 294 0.00653133776321007 22 4672763
SGTC_2733 amorolfine 100 µM 2.47493348506435 0.0394456229287343 no 295 0.00666304959380081 15 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_3075 9116269 49.47 µM 2.47454132373987 0.0394713079596228 no 296 0.00667036931461002 30 17015205 YNL244C SUI1
SGTC_3011 9081274 71.4286 µM 2.47428654349266 0.0394880023575648 no 297 0.00667512861519336 28 6625322
SGTC_2789 5281112 71.43 µM 2.47228147135547 0.0396195846516017 no 298 0.00671268828078672 29 765948
SGTC_3242 9133940 49.47 µM 2.46502282962496 0.0400989157837033 no 299 0.00685022610040667 26 17248444
SGTC_2340 7987427 183.45 µM 2.43927928892916 0.0418370274588111 no 300 0.00735829471470026 32 2239331
SGTC_689 0833-0039 98 µM 2.43441203592411 0.0421724067076026 no 301 0.00745800241834786 28 5374726
SGTC_517 1365-0151 113 µM 2.43355363607031 0.04223178003167 no 302 0.00747571004473331 34 768657
SGTC_920 mycophenolic acid 780.421 nM 2.43306015766685 0.0422659432778848 no 303 0.00748590659430203 30 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_707 0865-0008 204 µM 2.42786815076687 0.0426267400183054 no 304 0.00759393179756072 25 723043
SGTC_2553 4-methylesculetin 85.09 µM 2.41954059965339 0.0432106245793046 no 305 0.00777006293380544 23 5319502
SGTC_2881 9058953 51.95 µM 2.41820958900772 0.043304544041632 no 306 0.0077985450754099 39 17122249
SGTC_2506 ethyl hematommate 54.16 µM 2.4085539779317 0.0439908132794592 no 307 0.00800792886361979 24 3940691 An allergen.
SGTC_2730 imipramine 71.33 µM 2.40344484622043 0.0443574757822512 no 308 0.00812070839227828 31 3696 A tricyclic antidepressant.
SGTC_157 1348-1695 65.819 µM 2.40205908396213 0.0444573500028589 no 309 0.00815153749014949 65 5380510
SGTC_1322 1348-1070 12 µM 2.39985304361439 0.0446167167719918 no 310 0.00820082752424556 19 6758089
SGTC_34 0469-0683 81.75 µM 2.39882989911613 0.0446907858870417 no 311 0.00822377660615294 26 3690923
SGTC_2441 5730946 39.09 µM 2.3945440071376 0.045002133959273 no 312 0.00832052317764693 32 1774275
SGTC_1601 4'-hydroxyflavanone 55.5 µM 2.38414804733989 0.045764603219748 no 313 0.00855935699413873 37 165506
SGTC_286 k060-0067 22.9 µM 2.37833965921308 0.0461951073355372 no 314 0.00869539921269028 38 5985051
SGTC_2663 amphotericin b 100 µM 2.37455472369143 0.046477383801073 no 315 0.00878506575862903 43 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2982 9019404 25.97 µM 2.3686561919783 0.0469200483338821 no 316 0.00892642022531592 26 22333232
SGTC_1167 k781-0610 148 µM 2.36137186739293 0.0474713710233898 no 317 0.00910373134767584 37 4525169
SGTC_944 3370-0224 231 µM 2.35143827324735 0.0482315581879815 no 318 0.00935049608367944 30 4580514
SGTC_1452 4194-0072 190 µM 2.35047451869152 0.0483058267040818 no 319 0.00937474568813595 37 1343545
SGTC_725 1497-0963 19 µM 2.3424995319249 0.0489239084555077 no 320 0.00957752900331287 26 3549977
SGTC_3200 9114385 49.47 µM 2.33967486412257 0.0491443368280492 no 321 0.00965026703405143 41 17018030 YLR208W SEC13
SGTC_3065 9113888 49.47 µM 2.33674097078114 0.0493741279009965 no 322 0.00972632840613272 34 16648368
SGTC_218 alverine citrate 93.75 µM 2.33512071070843 0.0495013985830829 no 323 0.00976855783995937 34 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_2306 7482397 179.52 µM 2.33285320822316 0.0496799493420187 no 324 0.0098279254703041 42 891448
SGTC_2142 5622915 118.518 µM 2.33263396659047 0.049697240374112 no 325 0.0098336823155287 17 5322196
SGTC_3008 9078912 71.4286 µM 2.32027230141242 0.0506799660899343 no 326 0.0101630757590652 24 16648731
SGTC_2737 bleomycin 30.5 nM 2.31346052179646 0.0512280656318144 no 327 0.0103486664413146 43 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_1016 4226-1401 38 µM 2.31291086136709 0.0512724980724985 no 328 0.010363770268778 46 2901613
SGTC_1984 st072354 53.1 µM 2.3038566269159 0.052008828768224 no 329 0.0106153465678964 27 5762938
SGTC_3079 9117512 49.47 µM 2.29710984833137 0.0525629501245728 no 330 0.0108062520538091 22 7185044
SGTC_2402 5553605 200 µM 2.29674613754979 0.0525929547466423 no 331 0.0108166279078893 38 6758546
SGTC_1621 st003705 32.4 µM 2.28398845055917 0.0536540376661878 no 332 0.0111861048586478 39 24207032
SGTC_1732 st034308 51.822 µM 2.28071859059449 0.0539287107840317 no 333 0.0112825521817038 45 830119
SGTC_777 1315-0167 517 µM 2.27975348761358 0.0540099933055056 no 334 0.0113111565156917 31 4221767
SGTC_2854 9024559 71.43 µM 2.27338156508693 0.0545490832307999 no 335 0.0115015980430373 37 3163529
SGTC_2152 5568786 200 µM 2.26938366481732 0.0548894881408683 no 336 0.0116225023419517 33 5399883
SGTC_3028 9087778 49.47 µM 2.26918791331968 0.0549061985997735 no 337 0.01162845048134 30 17217395
SGTC_1812 st052057 4.327 µM 2.25242973119042 0.0563517380332208 no 338 0.0121475643252174 49 3645418
SGTC_1187 1391-0724 117 µM 2.25174984023261 0.0564110118029389 no 339 0.0121690425532609 31 6997986
SGTC_3263 9137018 49.47 µM 2.25158343630293 0.0564255265946745 no 340 0.0121743043801856 43 43844957
SGTC_2483 5729050 27.16 µM 2.23190184833948 0.0581631382715184 no 341 0.012810725355234 47 2865180
SGTC_2455 5377712 9.75 µM 2.22813103362876 0.0585007985013624 no 342 0.0129358891850667 36 2243908
SGTC_1160 4092-0570 10.5 µM 2.22400722875796 0.0588718275247938 no 343 0.0130739789452109 49 4994975
SGTC_2041 5107442 45.335 µM 2.21279935663149 0.0598895597619414 no 344 0.013455740833468 78 793005
SGTC_711 k292-0785 179 µM 2.20970142966474 0.0601732847033789 no 345 0.0135629452361902 48 4146315
SGTC_1901 st060216 58.6 µM 2.2022608945875 0.0608590279012079 no 346 0.0138234424031623 35 688792
SGTC_1614 st002383 48.6 µM 2.20128212792416 0.0609496870955694 no 347 0.0138580286460562 24 1947235
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 2.1847129967428 0.0625004931461633 no 348 0.0144549483238296 47 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_2256 7954252 200 µM 2.18019299068802 0.0629288446770074 no 349 0.0146215794839351 48 2972920
SGTC_766 1391-0721 126 µM 2.17804928332602 0.0631327972720329 no 350 0.0147011839136478 43 1020919 YIL115C NUP159
SGTC_1490 4089-0339 670 nM 2.17767139220392 0.0631688031924342 no 351 0.0147152551083807 39 742542
SGTC_2126 5251174 33.877 µM 2.17611120317296 0.0633176292013958 no 352 0.0147734732053926 43 790722
SGTC_623 k072-0108 16.9 µM 2.16878533167811 0.0640200949591924 no 353 0.0150494926871226 57 5382803
SGTC_371 0195-0006 7.36 µM 2.16742293703285 0.0641513984584156 no 354 0.0151013099411565 48 3928593
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 2.16263293270729 0.0646147070587975 no 355 0.0152847116002279 14 4000243
SGTC_2032 5185112 25.99 µM 2.1617869659004 0.064696801758188 no 356 0.0153173003056026 21 5718189
SGTC_3216 9129716 49.47 µM 2.16150933533496 0.0647237613577742 no 357 0.0153280083090078 37 8056934
SGTC_1717 st033143 58.0435 µM 2.15892947375756 0.0649746988208409 no 358 0.0154278194260198 35 674616
SGTC_3351 9150312 21.596 µM 2.15679358108564 0.0651830232851864 no 359 0.015510875745666 64 4904905
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 2.15280880070063 0.0655730641414923 no 360 0.0156668541042004 71 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_3167 9103034 49.47 µM 2.14805595892982 0.0660406486933587 no 361 0.0158546551534353 27 5127859
SGTC_2882 9058044 58.44 µM 2.14734586122378 0.0661107293607349 no 362 0.0158828786408358 41 18076804
SGTC_1166 k206-0078 225 µM 2.14387851233544 0.0664537552659147 no 363 0.0160213111648648 37 5404595
SGTC_1145 3546-0597 10.2 µM 2.1434857943891 0.0664926936895231 no 364 0.0160370552785791 33 875334
SGTC_314 1671-0008 2.74 µM 2.13942498149555 0.0668963641000569 no 365 0.0162006327638251 58 3913060
SGTC_1173 0443-0020 122 µM 2.13917886458685 0.06692089047256 no 366 0.0162105926115074 42 5331295
SGTC_1638 st008370 60.6 µM 2.13817096204202 0.0670214039080713 no 367 0.0162514351107713 57 24207134
SGTC_3031 9088762 49.47 µM 2.13621041615857 0.0672172544522856 no 368 0.0163311334097516 42 205253
SGTC_873 0591-4978 488 µM 2.136178276523 0.0672204687533693 no 369 0.0163324427041248 44 3305145
SGTC_1553 gossypol 38.6 µM 2.13147602161657 0.0676920255033915 no 370 0.016524972905039 22 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_763 3453-1109 128 µM 2.1285572981538 0.0679860070405367 no 371 0.0166454523149183 38 1560353
SGTC_3274 9138298 49.47 µM 2.12803884451305 0.0680383300129196 no 372 0.0166669315311236 47 17015756
SGTC_1529 apigenin 74 µM 2.12095671197667 0.0687561841347645 no 373 0.0169627227168111 42 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_2020 4017018 200 µM 2.11841537415967 0.0690151964703981 no 374 0.0170699524816472 44 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_2954 9074818 52.69 µM 2.11576074486036 0.0692865578185298 no 375 0.0171825806518324 48 16648742
SGTC_3256 9138902 49.47 µM 2.11407210203054 0.0694596014106279 no 376 0.0172545547686939 19 17228773
SGTC_3355 9151058 44.0485 µM 2.1133954756092 0.069529031997563 no 377 0.0172834664460332 42 17015728
SGTC_485 niflumic acid 177 µM 2.10953928936836 0.0699257469917312 no 378 0.0174490292013918 40 4488 A COX2 inhibitor.
SGTC_1054 3429-0080 167 µM 2.10663874620957 0.0702252938406801 no 379 0.0175744527395512 39 1162877
SGTC_2004 4023728 41.89 µM 2.10415900601928 0.0704821649196832 no 380 0.0176822895644708 76 360084 YDR527W RBA50
SGTC_413 propylparaben 100 µM 2.10206709799342 0.0706994224466135 no 381 0.0177736992732431 39 7175 A pharmaceutical preservative.
SGTC_3267 9137951 49.47 µM 2.10115547639344 0.0707942608067291 no 382 0.0178136601772193 33 16643986
SGTC_1436 4092-1007 8.32 µM 2.09937223263583 0.0709800588530466 no 383 0.0178920502353732 35 2881121
SGTC_1756 st041558 35.5 µM 2.09833358898412 0.0710884487001887 no 384 0.0179378436735291 44 3955792
SGTC_343 4130-2827 29.8 µM 2.09828059383881 0.0710939825265032 no 385 0.0179401828886476 37 1118244
SGTC_1820 st053765 18.6 µM 2.09038962938218 0.0719216654716514 no 386 0.0182914068605679 36 3690829
SGTC_3124 9127567 49.47 µM 2.08301088653303 0.0727022878563284 no 387 0.0186251156252103 42 17592030
SGTC_2985 9022375 71.43 µM 2.07682438328865 0.0733617656286976 no 388 0.0189088854373625 49 4939335
SGTC_984 1492-0255 2.91 µM 2.07644884783645 0.0734019443225019 no 389 0.0189262287076208 32 1585198
SGTC_2391 6285546 200 µM 2.07525716334203 0.073529554586018 no 390 0.0189813536307287 47 846083
SGTC_121 0557-0495 61.343 µM 2.07061994849813 0.0740277406659927 no 391 0.0191971632244695 59 3104427
SGTC_2580 diallyl disulphide 81.36 µM 2.06136412958525 0.075029818466351 no 392 0.0196341571457917 50 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_1218 1348-1416 30.7 µM 2.05735907349893 0.0754666176568218 no 393 0.0198258494287529 55 6787668
SGTC_961 1252-1571 372 µM 2.05468264820459 0.0757595922517487 no 394 0.0199548334947899 65 6813498
SGTC_1932 st074806 40.9 µM 2.04840651247489 0.0764500056125491 no 395 0.0202600919741767 56 17251235
SGTC_1931 st074438 57.1 µM 2.04740107146149 0.0765610537195232 no 396 0.0203093606339395 74 2787313
SGTC_1062 mesoridazine 14.2 µM 2.04407117246135 0.0769297077437378 no 397 0.0204732582679682 51 4078 A neuroleptic.
SGTC_1325 1431-0015 227 µM 2.04394573104608 0.0769436217242309 no 398 0.0204794543368056 35 1103340
SGTC_911 3456-4043 236 µM 2.03681224437762 0.0777380205125857 no 399 0.0208344304052791 56 914281
SGTC_3122 9126309 49.47 µM 2.03379170130989 0.0780762641324796 no 400 0.0209863008042862 56 17591206
SGTC_2922 7999257 32.47 µM 2.03363001978183 0.0780944008330506 no 401 0.0209944563655826 45 2988377
SGTC_1761 st044296 37 µM 2.03283744471432 0.0781833545470981 no 402 0.021034474354163 56 1826700
SGTC_2555 cholic acid 100 µM 2.03271159071604 0.0781974866877863 no 403 0.021040834795962 29 6708657 Influences liver metabolism.
SGTC_2602 kawain 100 µM 2.03173940339769 0.0783067188616329 no 404 0.0210900223121288 46 5369129
SGTC_1221 2958-7315 257 µM 2.02579883573996 0.0789766990913326 no 405 0.0213927016491044 56 4562705
SGTC_1425 4048-4433 7.33 µM 2.02458836357151 0.0791137476913972 no 406 0.0214548250586016 44 23734946
SGTC_2183 6420625 130.508 µM 2.01238111502333 0.0805059231946908 no 407 0.0220898888362406 67 2897619
SGTC_2465 5809242 33.21 µM 2.00864563521111 0.080935612685379 no 408 0.0222873639900377 39 2731748
SGTC_2656 pseudo-anisatin 100 µM 2.00834288262612 0.080970513789246 no 409 0.0223034339679471 20 6708809 A neurotoxin.
SGTC_1127 asiatic acid 681.4 nM 2.00287083625256 0.0816032872146589 no 410 0.0225955770631713 48 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_1165 k072-0275 30.3 µM 2.00122484223449 0.0817943533134792 no 411 0.0226840824818439 58 6153523 YGL055W OLE1
SGTC_2042 p-Dimethylaminoacetophenone 200 µM 1.99791805096671 0.0821792227480798 no 412 0.022862772656896 46 75037 A free radical scavenger.
SGTC_26 0302-0163 425.158 µM 1.98986646864376 0.083122029079811 no 413 0.0233028234879909 64 3100915
SGTC_1670 st016595 4.04 µM 1.98862191588994 0.0832684838817447 no 414 0.0233714752597106 40 597879
SGTC_600 1495-0418 41.6 µM 1.98825732184544 0.0833114248077558 no 415 0.023391619128265 61 5377768
SGTC_579 4491-1009 110 µM 1.97858219719992 0.0844570265725256 no 416 0.0239315328433708 57 1271041
SGTC_2908 7930301 100 µM 1.9701222442336 0.0854683940030306 no 417 0.0244121810658967 53 2223178
SGTC_2512 diallyl trisulfide 49.23 µM 1.96349647361729 0.0862668022709568 no 418 0.0247942569162007 55 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_3273 9137859 49.47 µM 1.96315235202514 0.0863084209417143 no 419 0.0248142369839953 54 2377234
SGTC_2433 5607874 27.82 µM 1.96229683226887 0.0864119540729907 no 420 0.0248639679017738 45 2252428
SGTC_2944 9067346 25.62 µM 1.96118983294121 0.0865460584972084 no 421 0.0249284412212104 68 6473075
SGTC_2604 4'-hydroxychalcone 11.32 µM 1.95661314467691 0.087102140454785 no 422 0.0251964842038885 71 5282362
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 1.95509405009269 0.0872873037936799 no 423 0.0252859852093428 64 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_2711 st079103 59.1 µM 1.95379433951925 0.087445959428473 no 424 0.0253627719895649 40 54693780
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 1.95331155393002 0.0875049478449247 no 425 0.0253913446284272 52 5355888
SGTC_1564 D-Arginine 115 µM 1.95269691968986 0.0875800889493569 no 426 0.0254277594579457 76 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_2526 patulin 37.61 µM 1.94602125260833 0.0883993154004792 no 427 0.0258260933818015 72 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_2260 7964312 200 µM 1.94457657342518 0.088577353129165 no 428 0.0259129805479204 58 231951
SGTC_1120 ficusin 1.78878 µM 1.93314217732058 0.0899959253310532 no 429 0.026609342765873 53 6199 A DNA cross-linker.
SGTC_761 k216-0224 480 µM 1.93201824328759 0.0901362687351457 no 430 0.0266786270995476 60 1340404
SGTC_497 capsazepine 133 µM 1.9304526338478 0.090332034158669 no 431 0.0267753893585152 48 2733484 A calcium channel blocker.
SGTC_2191 5911152 200 µM 1.93045262714766 0.0903320349971359 no 432 0.0267753897732423 41 2875902
SGTC_750 4073-0104 132 µM 1.92963140742291 0.0904348473283038 no 433 0.0268262622046103 27 22330957
SGTC_2086 5274770 176.623 µM 1.92530559839135 0.0909778501502859 no 434 0.0270955688376286 69 689278
SGTC_1278 0874-0585 172 µM 1.92152038423369 0.091454974960913 no 435 0.0273330675152874 58 766306
SGTC_1842 st055362 61.2 µM 1.91796950095349 0.0919042460861556 no 436 0.027557439252656 41 676032
SGTC_1011 4112-3381 17.4 µM 1.91261312893506 0.0925850438689602 no 437 0.0278987988327403 56 2877139
SGTC_2529 gangaleoidin 93.61 µM 1.91184706861497 0.092682714686235 no 438 0.0279479062687675 40 4565183
SGTC_717 1532-0246 73.2 µM 1.90899690312782 0.0930467730460744 no 439 0.028131245584236 57 9561992
SGTC_643 k048-0106 28.4 µM 1.90500709478505 0.0935581746052407 no 440 0.0283895744322332 71 6763920
SGTC_2812 7970281 58.44 µM 1.90189139367924 0.0939589768800314 no 441 0.0285926772810405 64 2233435
SGTC_85 0868-0259 160.055 µM 1.8989755471505 0.0943352164516549 no 442 0.0287838455759467 53 83173
SGTC_1745 st081495 74 µM 1.89876791306653 0.0943620503553228 no 443 0.0287974988843554 95 13842402 YBL026W LSM2
SGTC_3290 9121031 71.43 µM 1.89557575760648 0.094775302118955 no 444 0.0290080826992494 50 17014854
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 1.89200575153196 0.095239047968529 no 445 0.0292451072452917 51 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2745 rifampicin 24.3 µM 1.89136547591837 0.0953223965447239 no 446 0.0292877869287653 18 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_1440 4100-1550 40 µM 1.89129934232051 0.0953310086168725 no 447 0.0292921982278914 46 742806
SGTC_11 0438-0307 1.3 µM 1.89120365686045 0.0953434700157413 no 448 0.02929858169705 74 4011476
SGTC_2315 7733312 200 µM 1.88505922641263 0.096146190276547 no 449 0.0297109210421953 67 726316
SGTC_700 3453-2283 142 µM 1.87946602467893 0.0968812068921779 no 450 0.030090444212136 61 565664
SGTC_1509 1326-1131 80 µM 1.87608608250309 0.0973273687210622 no 451 0.0303217302251133 37 768313
SGTC_2451 5856223 45.7 µM 1.86902268353787 0.098264620367201 no 452 0.0308098292831464 83 2179896
SGTC_631 k072-0230 41.5 µM 1.86661012321903 0.0985862559444138 no 453 0.0309780264405875 64 5773147
SGTC_1466 k213-0079 57.5 µM 1.86220521861991 0.0991754919967886 no 454 0.0312870845660819 90 3657981
SGTC_2228 7354201 200 µM 1.86219656951092 0.099176651500236 no 455 0.0312876939064268 53 753451
SGTC_607 4491-0986 66.8 µM 1.85658134756954 0.0999315246620004 no 456 0.0316853698408544 46 698981 YDR232W HEM1
SGTC_2504 purpurogallin 52.29 µM 1.8529906285902 0.100416431590522 no 457 0.0319418509417487 50 5281571 An antioxidant.
SGTC_1990 st072050 59.8 µM 1.84954654442314 0.100883147370043 no 458 0.032189466724252 52 17233948
SGTC_1911 st060208 74.3 µM 1.84824653546549 0.101059725114104 no 459 0.0322833431092214 62 688783
SGTC_317 4495-0002 170 µM 1.84790544528306 0.101106092029822 no 460 0.0323080113335827 52 15991618
SGTC_1825 st052143 62.6 µM 1.84729009508937 0.101189780354266 no 461 0.032352553855029 56 674173
SGTC_2496 diffractaic acid 79.83 µM 1.84614085069213 0.101346214049116 no 462 0.0324358783480709 71 94870 An apoptosis inducer which activates caspases.
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 1.84541340402736 0.101445324181613 no 463 0.0324887123839121 59 7104
SGTC_2883 9059145 45.46 µM 1.8366577449731 0.102643771526154 no 464 0.0331302184404061 67 16476510
SGTC_733 4069-0007 56.1 µM 1.83644894665489 0.102672476287863 no 465 0.033145643079569 79 5717425 YNL287W SEC21
SGTC_2450 5739737 12.93 µM 1.83502634957069 0.102868204580984 no 466 0.0332508926849237 53 2262825
SGTC_3051 9093778 49.47 µM 1.83221276702812 0.103256109911936 no 467 0.0334598637463144 59 17217378
SGTC_1846 st056244 14.8 µM 1.82772237050025 0.103877393946808 no 468 0.033795614499655 49 5393182
SGTC_1671 st016596 74.5 µM 1.82291233701003 0.104545905257915 no 469 0.0341583345477706 63 2829167
SGTC_423 5-fluorouracil 457 µM 1.81930317675693 0.105049558770269 no 470 0.034432594503553 97 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_179 1273-0063 6.77 µM 1.81857818267294 0.105150942200517 no 471 0.0344879044310969 40 3108139
SGTC_704 1310-0270 142 µM 1.80603871323316 0.106915681808848 no 472 0.0354561463594945 54 5718033
SGTC_1870 st057514 26.5 µM 1.8033697289633 0.107294042837445 no 473 0.0356650841865702 59 5393161
SGTC_559 1550-0661 158 µM 1.79947274904682 0.107848219457738 no 474 0.0359719654163369 56 5830875
SGTC_2463 5473429 200 µM 1.7987772866717 0.107947335258368 no 475 0.0360269588070535 51 5399405
SGTC_1744 st037937 38.9 µM 1.7975073141169 0.108128498239603 no 476 0.0361275590144716 63 1016152
SGTC_89 0302-0250 142.109 µM 1.79570023792731 0.1083866567878 no 477 0.0362711020169562 73 4203518 YLR208W SEC13
SGTC_2940 9060638 45.86 µM 1.79353250102906 0.108696923999691 no 478 0.036443909289694 59 4027022
SGTC_2762 leflunomide 42.06 µM 1.78408994876613 0.110055883131917 no 479 0.0372045251362802 81 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_819 1013-0258 27.7 µM 1.78029813396526 0.110605012053744 no 480 0.0375135911815281 64 5753198
SGTC_210 3551-0445 56.827 µM 1.78025790755362 0.110610848133045 no 481 0.03751688119065 66 2865180 YOR207C RET1
SGTC_283 0987-0079 11.7 µM 1.7681041609181 0.112384242890679 no 482 0.038521745986998 51 411556
SGTC_3080 9117754 49.47 µM 1.76677823353323 0.112578935597236 no 483 0.0386326876867921 69 9550191
SGTC_2793 7325131 81.82 µM 1.7664368741172 0.112629098118516 no 484 0.0386612916785674 63 4176441
SGTC_1155 4088-0394 48.2 µM 1.76432891202882 0.112939215294501 no 485 0.0388383094982981 73 2326248
SGTC_2763 lisinopril 49.32 µM 1.76338754195907 0.113077903579893 no 486 0.0389175747589307 58 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_1554 st069299 38.7 µM 1.76290554140074 0.113148961819521 no 487 0.0389582111458958 63 24207999
SGTC_436 n,n-dimethylsphingosine 3.3 µM 1.762856857536 0.113156140739477 no 488 0.0389623174938624 60 5282309
SGTC_1058 3448-5425 97.3 µM 1.76118394488639 0.113403025830224 no 489 0.039103637272045 81 7279705
SGTC_2078 5212016 200 µM 1.75908195332942 0.113713777814216 no 490 0.0392817948429562 60 1899708
SGTC_138 0850-0259 40.9225 µM 1.75278030366166 0.114649030497324 no 491 0.0398198626458762 117 6813004
SGTC_629 3448-6466 76.7 µM 1.75252005821014 0.11468777190345 no 492 0.0398422119542264 67 573744
SGTC_1233 0325-0408 14.2 µM 1.75165640869032 0.114816405729331 no 493 0.0399164533567741 57 12874
SGTC_719 2810-4230 27.3 µM 1.74638371163207 0.115603958958137 no 494 0.0403721491892727 45 721079
SGTC_149 3970-0822 46.1 µM 1.7446962150505 0.115856819650197 no 495 0.0405188812525523 84 3114250 YBL034C STU1
SGTC_3087 9117406 49.47 µM 1.74184877042989 0.116284381215232 no 496 0.0407674550841286 68 42546093
SGTC_1768 st044301 37.178 µM 1.73906332777838 0.116703714921187 no 497 0.0410118121583266 82 3931349
SGTC_2661 dactinomycin 12.96 µM 1.73882589449066 0.116739508778242 no 498 0.0410326961722336 57 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_2412 st077135 33.4 µM 1.73764402615609 0.116917795152363 no 499 0.0411367785828876 72 13258915
SGTC_3352 9151559 45.5865 µM 1.73057821473411 0.117987707969384 no 500 0.0417635100034859 57 17159339
SGTC_1181 1222-0449 220 µM 1.72770864506334 0.118424192860464 no 501 0.0420202364239218 73 658318
SGTC_1253 0550-0034 176 µM 1.72570998171272 0.118728879364062 no 502 0.0421998006916916 84 5969915
SGTC_2804 7954240 19.48 µM 1.72527483012947 0.118795289453198 no 503 0.0422389778506981 90 828705
SGTC_2983 9022671 12.99 µM 1.72377978644306 0.119023653508889 no 504 0.0423738025133632 66 6405161
SGTC_397 arbidol 50 µM 1.72331771760339 0.119094295992316 no 505 0.042415542735253 71 131410 A RNA synthesis inhibitor.
SGTC_1136 pergolide 1.05886 µM 1.72207051925854 0.119285119211603 no 506 0.042528372375437 103 47811 A dopamine receptor agonist.
SGTC_2212 7123476 200 µM 1.72186677885152 0.119316312292835 no 507 0.0425468270947096 32 1085715
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 1.72048383655423 0.11952819579522 no 508 0.0426722646429582 62 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_3143 9086658 49.47 µM 1.71762969088858 0.119966324326363 no 509 0.042932090568028 83 25236626
SGTC_2926 9010726 65.15 µM 1.71198368965987 0.120836351224003 no 510 0.0434498371394699 66 2994293
SGTC_322 k048-0136 19.3 µM 1.71197772511867 0.120837272678664 no 511 0.0434503867500069 81 6823282
SGTC_373 0844-0104 25.9 µM 1.70966562304003 0.121194839077378 no 512 0.043663861567792 95 5375804
SGTC_486 niguldipine 82 µM 1.70823469448707 0.121416504506874 no 513 0.0437964016568158 64 1236 A calcium channel blocker.
SGTC_289 k017-0060 526 µM 1.70587392479045 0.121782834574359 no 514 0.0440157777748632 65 5512909
SGTC_3258 9138477 49.47 µM 1.70432165354638 0.122024129471641 no 515 0.0441605058849138 65 4970355
SGTC_469 w7 172 µM 1.70391746237414 0.122087014572026 no 516 0.0441982540818203 53 45115570 A P450 inhibitor.
SGTC_2269 7935389 174.42 µM 1.70313658536022 0.12220856986719 no 517 0.0442712553650488 81 97605
SGTC_1027 k015-0025 8.67 µM 1.70180031793564 0.122416777119208 no 518 0.044396403447502 67 3598955
SGTC_2088 5278280 127.392 µM 1.70031104516391 0.122649117711705 no 519 0.0445362169812519 73 791502
SGTC_681 1642-0006 26.6 µM 1.69921570975412 0.122820197667766 no 520 0.044639273719899 76 4446530
SGTC_3121 9125696 49.47 µM 1.69591265668511 0.123337113060902 no 521 0.0449512111852985 48 1235365
SGTC_1996 st072960 66.8 µM 1.69550040368752 0.123401735940555 no 522 0.0449902668681985 76 1719405
SGTC_363 0455-0021 3.06 µM 1.69518562338715 0.123451095417409 no 523 0.0450201066494358 95 4597466
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 1.69489704985006 0.123496357662675 no 524 0.0450474761384942 84 5024745
SGTC_2871 9038510 12.99 µM 1.69431702964977 0.123587367955448 no 525 0.0451025281231533 102 4945164
SGTC_1689 st020265 53.493 µM 1.69430209125225 0.123589712542237 no 526 0.0451039466996997 74 5758320 YPR016C TIF6
SGTC_862 0452-0056 10.2 µM 1.69343331144975 0.123726121427263 no 527 0.0451865093441664 46 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_2878 9043973 25.97 µM 1.67596453403489 0.126491318201321 no 528 0.0468725698539965 48 6465167
SGTC_1338 1486-1223 76 µM 1.67396206182865 0.126811025928754 no 529 0.0470690278294509 73 3444526
SGTC_1966 st070145 16.1 µM 1.6715009815435 0.127204723481003 no 530 0.0473113824969854 88 3748532
SGTC_2948 9070189 9.45 µM 1.67060285008452 0.12734860860649 no 531 0.0474000745882682 66 6473636 YDL196W YDL196W
SGTC_1303 1160-0052 261 µM 1.66931529281623 0.127555079091256 no 532 0.0475274555190401 65 3562476
SGTC_2052 5265182 7.135 µM 1.66688816833638 0.127944921269197 no 533 0.0477683219873588 76 1239884
SGTC_3163 9099914 49.47 µM 1.6664761909186 0.128011174743168 no 534 0.047809303263055 67 16268368
SGTC_990 3985-0011 41.3 µM 1.66601440440995 0.128085466752769 no 535 0.0478552727324975 79 5399565 YGL099W LSG1
SGTC_3325 9138760 55.175 µM 1.66579960254684 0.128120034185173 no 536 0.0478766676722599 65 43844959
SGTC_472 calcifediol 10 µM 1.66402973137725 0.128405101003219 no 537 0.0480532440135324 53 5283731 A vitamin D metabolite.
SGTC_933 2914-0560 114 µM 1.66032787068143 0.129002769318798 no 538 0.0484242559192767 76 463887
SGTC_1891 st059073 26.2 µM 1.65751871946252 0.129457594479939 no 539 0.0487073237215009 84 688754
SGTC_3056 9094900 49.47 µM 1.65550318213797 0.129784610705563 no 540 0.0489112357357448 75 25236784
SGTC_37 0566-0070 1.56 µM 1.65427582271179 0.129984026899874 no 541 0.0490357415326102 72 1626686
SGTC_799 1310-0557 151 µM 1.65053527820578 0.130593082611868 no 542 0.0494167520173232 90 5354492
SGTC_1098 clofazimine 15.1 µM 1.64534151552309 0.131442026829804 no 543 0.049949701486841 111 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_956 1185-0240 191 µM 1.64453100514396 0.131574851346928 no 544 0.0500332826363343 67 1416193
SGTC_1759 st043059 70 µM 1.64322865421871 0.131788471491997 no 545 0.0501678167034639 91 669426
SGTC_3193 9111931 49.47 µM 1.64220126167751 0.131957159911372 no 546 0.0502741506608667 77 17087244
SGTC_1273 0849-0096 14.1 µM 1.64008018796048 0.132305891681479 no 547 0.0504942475940394 96 5286025
SGTC_2468 5987765 72.9 µM 1.63949989025546 0.132401410651251 no 548 0.0505545967559734 71 26772094
SGTC_2287 7945887 168.79 µM 1.63878197470708 0.13251964773695 no 549 0.0506293372434435 87 1245853
SGTC_1502 4534-4282 27.7 µM 1.63809161019359 0.132633415902898 no 550 0.0507012924415872 74 3278949
SGTC_2204 7233102 200 µM 1.63536876697274 0.133082780940862 no 551 0.050985882867742 73 2172480
SGTC_811 0416-0114 265 µM 1.63221200536252 0.133605068140725 no 552 0.0513174162884458 81 6612453
SGTC_1949 st076024 69.1 µM 1.63207873257131 0.133627149131425 no 553 0.0513314506722512 74 2921930
SGTC_2644 guaiazulene 100 µM 1.62832945070144 0.134249368536188 no 554 0.0517275239926809 53 3515 A coloring agent.
SGTC_147 4466-0538 29.23 µM 1.62706183455262 0.134460187660287 no 555 0.0518619828679402 86 6742687 YHR072W ERG7
SGTC_2 0422-0095 29 µM 1.62698447882504 0.134473060160453 no 556 0.0518701971463774 74 6790840
SGTC_159 3970-0959 50 µM 1.62658615850091 0.134539356667673 no 557 0.051912510501376 116 6615653
SGTC_1252 0493-0875 34.8 µM 1.6251214474862 0.134783336359565 no 558 0.0520683418870697 65 3960963
SGTC_3255 9139072 49.47 µM 1.62170322147398 0.135353897105275 no 559 0.0524334543576688 73 17646060
SGTC_104 0074-0074 590.992 µM 1.62112704193356 0.135450234188169 no 560 0.0524951977701231 90 3943124
SGTC_544 k015-0020 52.4 µM 1.61766573646465 0.136029952563834 no 561 0.0528673269471521 97 3008304
SGTC_2406 ethylparaben 405.7 µM 1.6163273449982 0.136254568384288 no 562 0.0530117788290235 71 8434 A possible steroid mimic.
SGTC_1087 pterostilbene 9.05 µM 1.61590857971072 0.136324899851131 no 563 0.0530570401775259 98 5281727 Similar to reservatol, lowers cholesterol.
SGTC_2359 9039622 200 µM 1.61511005725535 0.136459080214508 no 564 0.0531434316886158 74 6463596
SGTC_84 0443-0269 128.823 µM 1.61507501024138 0.136464971436437 no 565 0.0531472259506596 81 6150058
SGTC_565 1418-0001 44.5 µM 1.61478296749156 0.136514069078127 no 566 0.0531788514535319 87 2862145
SGTC_1758 st042942 75.2445 µM 1.61286138545216 0.136837422860155 no 567 0.0533873130447719 87 669317
SGTC_2092 5303694 80.6725 µM 1.60938808748872 0.137423218740573 no 568 0.0537657542232915 90 1963699
SGTC_133 0724-0033 378.92 µM 1.60802061084369 0.137654322295434 no 569 0.0539153324040808 92 280309
SGTC_2251 lansoprazole 556 µM 1.60518018592048 0.138135201394733 no 570 0.0542270783309512 65 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_957 1187-1561 14.1 µM 1.60353245706641 0.138414683461122 no 571 0.0544085746201533 89 1538454
SGTC_1832 st054113 55 µM 1.60291759050667 0.138519073667255 no 572 0.0544764247650156 63 1251267
SGTC_1954 st077032 68.9 µM 1.6023236818349 0.138619956628008 no 573 0.0545420257423623 78 698907
SGTC_399 oxolinic acid 75 µM 1.60075505569617 0.138886648423375 no 574 0.0547155908686758 81 4628 A DNA gyrase inhibitor.
SGTC_926 2268-1401 59.4 µM 1.5994825640861 0.139103249070435 no 575 0.0548567098853644 88 2931578
SGTC_2242 6630449 61.2675 µM 1.59890684906491 0.139201321485796 no 576 0.054920650989828 69 691249 YDR170C SEC7
SGTC_648 0375-0473 33.3 µM 1.59839225305471 0.139289022163254 no 577 0.0549778538235081 91 1713139
SGTC_1290 0986-0249 10.2 µM 1.59830749020629 0.139303471584734 no 578 0.0549872806324938 82 53329
SGTC_2639 lactacystin 53 µM 1.59745928578316 0.139448120145311 no 579 0.0550816831295155 80 3870 A proteasome inhibitor.
SGTC_2185 6113692 200 µM 1.59637325034395 0.139633476330568 no 580 0.0552027423549346 89 874150
SGTC_2785 7756463 72.73 µM 1.59588046905163 0.139717635685384 no 581 0.055257741434824 120 2201551
SGTC_1205 4161-2785 76 µM 1.59383975732657 0.140066524474252 no 582 0.0554859651272573 75 3498106
SGTC_303 1348-1668 34.2 µM 1.5916423210195 0.140442868904951 no 583 0.0557325475751907 81 5380509
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 1.59088045871269 0.140573509560094 no 584 0.0558182405577142 82 279621
SGTC_3165 9101544 49.47 µM 1.59037177120695 0.140660782872247 no 585 0.0558755147230246 83 5002184
SGTC_1358 1509-0022 2.48 µM 1.59023890033844 0.140683585007367 no 586 0.0558904825597485 94 3258434
SGTC_1782 st039423 80.636 µM 1.58875053871864 0.140939176027438 no 587 0.0560583619969229 72 2068169
SGTC_1956 st077085 54 µM 1.57923221433954 0.142581169954362 no 588 0.0571414017193605 102 24208685
SGTC_1351 1496-0003 46.5 µM 1.57790793701712 0.142810640315524 no 589 0.0572933806666349 81 3891978
SGTC_1905 st060207 84.5 µM 1.57670626964733 0.143019080782787 no 590 0.0574315635505256 102 1948547
SGTC_3184 9108758 49.47 µM 1.57265001133449 0.143724194273359 no 591 0.0578999403447806 80 902885
SGTC_306 1672-3436 11.6 µM 1.57147406150039 0.143929051592707 no 592 0.0580362873980952 79 6797378
SGTC_3084 9116877 49.47 µM 1.57132422701775 0.143955167772801 no 593 0.0580536782631007 65 27241325
SGTC_288 1315-0019 35.1 µM 1.56726848760526 0.144663298221918 no 594 0.0585259739461297 126 6811474
SGTC_569 4130-2812 160 µM 1.55868038096921 0.146170511338609 no 595 0.0595360237664337 81 743552
SGTC_2850 9015429 58.44 µM 1.55808175375913 0.14627596224102 no 596 0.0596069347092479 99 6457570
SGTC_654 1124-0271 80.9 µM 1.55768446106983 0.146345975349399 no 597 0.0596540329123542 96 5403748
SGTC_2742 clothiapine 36.27 µM 1.55523595263082 0.146777961604138 no 598 0.05994494233378 55 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_679 0422-0091 41.4 µM 1.5540519167035 0.14698716564722 no 599 0.0600860166513896 103 627384 YHR062C RPP1
SGTC_901 1112-0062 60.1 µM 1.55002567231617 0.147700047164505 no 600 0.0605676771543479 75 1908457
SGTC_1044 1222-0021 1.78 µM 1.54582422634227 0.148446414538189 no 601 0.0610735122376096 119 4306703
SGTC_273 hydroxyurea 18.1 mM 1.54496554975217 0.148599264334374 no 602 0.061177298247765 113 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_1263 0774-1208 64.8 µM 1.54303273121225 0.148943702968644 no 603 0.061411417265596 109 906585
SGTC_2673 kobusone 100 µM 1.53928575437299 0.149612952617702 no 604 0.0618672750949055 73 6710676 An epoxy ketone and protein crosslinker.
SGTC_2978 9011784 42.97 µM 1.53530214923385 0.150326663970025 no 605 0.0623548132348756 79 2994934
SGTC_1665 st014639 11.4 µM 1.53476405841994 0.150423243126535 no 606 0.0624208971590882 101 981133 YIL048W NEO1
SGTC_1229 0139-0193 12.2 µM 1.53392208728348 0.150574447133551 no 607 0.0625244107490543 117 3090752
SGTC_791 1348-1292 225 µM 1.52877233259033 0.151501459879986 no 608 0.0631604467547564 87 5437054
SGTC_2027 5150920 200 µM 1.52744182222515 0.151741581959972 no 609 0.0633255917465361 72 786715
SGTC_123 0083-0120 66.675 µM 1.52360443290888 0.152435545603586 no 610 0.0638037775769855 102 16001701
SGTC_2872 9044037 25.97 µM 1.52330619480155 0.152489567843177 no 611 0.0638410590167885 75 6465195
SGTC_2898 9056270 58.44 µM 1.51813238847775 0.153428762321945 no 612 0.0644905138405332 49 19154699
SGTC_2628 lathosterol 100 µM 1.51735166345204 0.153570818357345 no 613 0.0645889604218381 97 6710616
SGTC_1223 0764-0573 147 µM 1.5077865775425 0.155318292568741 no 614 0.0658045792717621 84 1609797
SGTC_3156 9099931 49.47 µM 1.50347105549272 0.15611098758781 no 615 0.0663588077206865 87 18111053
SGTC_148 3253-0744 288.01 µM 1.49528698605123 0.157621584346215 no 616 0.0674197800078497 89 6893655
SGTC_1848 st056003 16.4 µM 1.49220708727075 0.15819254385872 no 617 0.0678224324891418 99 146492
SGTC_3264 9137442 49.47 µM 1.49201234324811 0.15822869157215 no 618 0.0678479547682018 91 17015726
SGTC_272 doxorubicin 8.13 µM 1.4899071283052 0.158619800288331 no 619 0.0681243285074235 101 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1769 st044406 64.4 µM 1.4896262903854 0.158672022490728 no 620 0.068161262663126 125 670903
SGTC_1443 4112-3303 14 µM 1.48711774789134 0.159138989460228 no 621 0.0684918574232166 112 704433
SGTC_3254 9136651 49.47 µM 1.48030381577364 0.160411946804369 no 622 0.0693960926967846 108 16454030
SGTC_2320 7373003 200 µM 1.47452351512157 0.161497005995716 no 623 0.0701703455625487 103 5415828
SGTC_2145 5634607 200 µM 1.47446898589211 0.161507264777585 no 624 0.0701776810858254 77 308662
SGTC_1797 st048695 56.8 µM 1.47214327699807 0.161945204336298 no 625 0.070491095532154 104 592262 YIL048W NEO1
SGTC_331 k048-0133 24.5 µM 1.46799020147078 0.162729166051665 no 626 0.0710534422649953 106 6813582
SGTC_1747 st037496 66.6 µM 1.46791403894641 0.16274356599921 no 627 0.0710637871199365 126 723305
SGTC_1214 0358-0031 63.7 µM 1.45537839054655 0.165124956863451 no 628 0.0727822677337097 107 4301366
SGTC_2499 avocadenofuran 51.48 µM 1.45524065776392 0.165151246552541 no 629 0.0728013243435062 102 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_250 brefeldin a 552.239 µM 1.45521062180682 0.165156980013504 no 630 0.072805480604495 76 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_3045 9092950 49.47 µM 1.45244010424283 0.165686388633423 no 631 0.0731896360043319 77 44120432
SGTC_2589 lobaric acid 100 µM 1.45164402333855 0.165838711703589 no 632 0.073300305610072 83 73157 A novel microtubule depolymerizer.
SGTC_2345 9052315 157.45 µM 1.44696944296084 0.166734977151868 no 633 0.0739527410191081 109 6469265
SGTC_3146 9095609 49.47 µM 1.44455631634713 0.167198870990815 no 634 0.0742912752169905 86 17173999
SGTC_1527 coumarin 137 µM 1.44291538818196 0.167514793981984 no 635 0.0745221538785773 113 323 A hepatotoxic, DNA x-linker.
SGTC_3140 9094243 49.47 µM 1.43857848018524 0.168351615908747 no 636 0.0751349935631276 113 19291112
SGTC_672 1441-0018 53.7 µM 1.43775563212651 0.168510690315851 no 637 0.0752517010650518 87 251141
SGTC_526 4469-0568 170 µM 1.43536801344927 0.168972815715016 no 638 0.0755911279500498 101 2901964
SGTC_1446 4239-0190 62 µM 1.43200266111862 0.169625563171155 no 639 0.0760715298680919 105 1340085
SGTC_1442 4112-3290 3 µM 1.42733499024156 0.170533583624011 no 640 0.0767416797714087 93 704353
SGTC_2365 9042475 200 µM 1.42120114714676 0.171731547423864 no 641 0.0776291456537743 100 6464479
SGTC_63 0099-0242 26.702 µM 1.42073089566388 0.171823610718572 no 642 0.0776975035361855 134 3898502 YLR359W ADE13
SGTC_54 0159-0055 9 µM 1.41824822973624 0.172310175966559 no 643 0.078059152725173 103 3319099
SGTC_2945 9067681 61.76 µM 1.41510145666322 0.172928158148201 no 644 0.0785193755905291 138 16456930
SGTC_33 0986-0033 35.816 µM 1.41483880711791 0.172979802621263 no 645 0.0785578815048739 71 2848082
SGTC_251 melphalan 456.522 µM 1.41216850702465 0.173505418312984 no 646 0.0789501755244514 127 460612 A DNA alkylator.
SGTC_1678 st019265 80.2 µM 1.41214698224219 0.173509659326952 no 647 0.0789533437499851 98 5367020
SGTC_780 0109-0199 192 µM 1.40921897133327 0.174087178246123 no 648 0.0793852148614987 126 610414
SGTC_2818 7996756 12.99 µM 1.40672971910933 0.174579116529197 no 649 0.0797537748445777 108 2241621
SGTC_2962 9082311 13.18 µM 1.40408416295645 0.175102911021219 no 650 0.0801468944889542 125 16459453
SGTC_2172 5754775 163.918 µM 1.40337106271074 0.175244268358832 no 651 0.0802531086974079 146 2263357
SGTC_1662 st014054 52 µM 1.40025654732567 0.175862504393243 no 652 0.0807182539506586 99 2838777
SGTC_458 nppb 133 µM 1.39979212836163 0.175954810469796 no 653 0.0807877878564479 90 4549 A chloride channel blocker.
SGTC_2067 5224629 34.075 µM 1.39653482099438 0.176603081932173 no 654 0.0812767511928912 115 2835000
SGTC_936 3005-4620 401 µM 1.39650540710294 0.176608942776918 no 655 0.0812811767417786 117 777207
SGTC_1651 st011928 86.1 µM 1.39570295558015 0.176768882151736 no 656 0.081401981961613 109 720198
SGTC_2725 haloperidol 53.21 µM 1.39491959721471 0.176925104296726 no 657 0.0815200433802317 125 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1195 1502-0147 41.1 µM 1.38947497577567 0.178013313611876 no 658 0.082344182616606 96 817940
SGTC_1591 genipin 88.4 µM 1.38838050098402 0.178232573230863 no 659 0.0825106053714342 119 442424 A DNA cross-linking agent.
SGTC_2033 5192550 145 µM 1.38669468666582 0.178570630609114 no 660 0.0827674407399415 103 182073
SGTC_126 0417-1624 672.48 µM 1.38582260893815 0.17874566726758 no 661 0.0829005384517692 148 41912 YDL195W SEC31
SGTC_1933 st074711 15.9 µM 1.3817794839288 0.179558582432479 no 662 0.0835197101479999 127 17250958
SGTC_2445 5742597 35.57 µM 1.38096831337482 0.17972195670065 no 663 0.0836443518080252 134 1774255
SGTC_3120 9124077 49.47 µM 1.38075673679743 0.179764584753865 no 664 0.0836768849008776 106 18774327 YGL155W CDC43
SGTC_818 4072-2707 53.5 µM 1.38032515285899 0.179851559170558 no 665 0.08374327691914 102 882871
SGTC_2773 thioridazine 9.09 µM 1.3795216672018 0.180013551013614 no 666 0.0838669852367039 99 5452 An antipsychotic.
SGTC_834 0312-0008 75.7 µM 1.37698617475695 0.180525335559683 no 667 0.0842582611328494 111 6385573 YIL048W NEO1
SGTC_2712 st079126 47.7 µM 1.3753484269097 0.180856396626942 no 668 0.084511724843594 97 3152970
SGTC_3118 9124250 49.47 µM 1.37441360794687 0.181045535251982 no 669 0.0846566569615931 109 1504786
SGTC_66 0109-0187 42.4 µM 1.37405617003226 0.181117887145413 no 670 0.0847121225271665 89 759417
SGTC_2797 7859098 81.82 µM 1.37350108646132 0.181230281991667 no 671 0.0847983118495004 119 972681
SGTC_2380 9035439 200 µM 1.37172434373254 0.181590335342657 no 672 0.0850746335558179 107 6462575
SGTC_1336 1486-0901 104 µM 1.36996581140731 0.181947138872178 no 673 0.0853487870920741 107 5006114
SGTC_3037 9091026 49.47 µM 1.367253711807 0.182498278552502 no 674 0.0857728974793783 115 25236398 YIL048W NEO1
SGTC_3275 9138069 49.47 µM 1.36652949871457 0.18264562583639 no 675 0.0858864142779656 119 17617007
SGTC_209 4077-0173 175.592 µM 1.36420875718929 0.183118300593824 no 676 0.0862509364103718 102 15993494
SGTC_174 3553-0389 74.3 µM 1.3641953129793 0.183121041051296 no 677 0.0862530514771796 103 738071
SGTC_1946 st076057 65.1 µM 1.36102743166656 0.183767492674257 no 678 0.0867525103394367 88 953009
SGTC_297 0986-0032 24 µM 1.35607692268834 0.184780557656911 no 679 0.0875373472943348 127 2847425
SGTC_329 k048-0121 21.3 µM 1.35565155654202 0.184867765630992 no 680 0.0876050298092663 105 6832902
SGTC_1703 st026983 48.3 µM 1.35418082635756 0.185169489754601 no 681 0.0878393472732926 93 1104023
SGTC_395 anisomycin 6.25 µM 1.35004424458673 0.186019758894975 no 682 0.0885008955552885 118 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_1201 1889-3372 45.9 µM 1.34865753017522 0.18630533715765 no 683 0.088723496374559 113 5392199
SGTC_274 sirtinol 40.1 µM 1.3485979891951 0.186317605032932 no 684 0.0887330634529139 126 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_1573 oleylamine 1.06 µM 1.34836229101733 0.186366173402262 no 685 0.0887709431095328 122 5356789 An amine of the fatty acid oleic acid.
SGTC_398 bronopol 33.3 µM 1.3470284840226 0.18664116770532 no 686 0.0889855295478284 127 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_2107 5363541 170.161 µM 1.346252869564 0.186801193526238 no 687 0.0891104898989565 120 244052
SGTC_2903 5923464 63.88 µM 1.34602877900455 0.18684744399995 no 688 0.089146617753525 114 2876576
SGTC_3356 9151811 4.48 µM 1.3456624705562 0.186923062351087 no 689 0.0892056974300237 123 1859254 YPR165W RHO1
SGTC_1190 1486-1332 13 µM 1.34286887702297 0.18750037645932 no 690 0.0896572178862796 123 4150046
SGTC_1497 4476-2978 41.3 µM 1.3423737415107 0.187602814244304 no 691 0.089737422173672 115 1528379
SGTC_1668 st014914 51.6 µM 1.33762838168131 0.188586327003934 no 692 0.0905088038813089 131 2839556
SGTC_424 splitomicin 100 mM 1.3373548883514 0.188643107347689 no 693 0.0905534111475546 120 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2570 licareol 100 µM 1.33499432468526 0.189133625305283 no 694 0.0909391019701085 119 443158
SGTC_264 promethazine 12.5 mM 1.33424695272632 0.18928909049092 no 695 0.0910614681909606 154 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_2171 5739187 198.077 µM 1.33423688712077 0.189291184832795 no 696 0.0910631170522748 108 2262761
SGTC_479 n-linoleoylglycine 10 µM 1.33393310496105 0.18935439923692 no 697 0.091112890464289 131 6433346 An anti-infammatory.
SGTC_516 3992-2719 87.3 µM 1.33326490403916 0.189493491709549 no 698 0.0912224433315137 88 5350887 YDR037W KRS1
SGTC_1344 1488-0097 29.1 µM 1.33270753824856 0.189609560859653 no 699 0.0913138992493562 125 747966
SGTC_3221 9128209 49.47 µM 1.33024662226064 0.190122559248785 no 700 0.0917185138321673 109 16460723
SGTC_409 arachidonic acid 100 µM 1.3283629125686 0.190515809901453 no 701 0.0920291226654905 114 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_1641 st009299 47.1 µM 1.32576199195387 0.19105960847296 no 702 0.0924592731232047 126 4046054
SGTC_32 0928-0142 34.1 µM 1.32543564410046 0.19112790819085 no 703 0.0925133506773686 123 2244242
SGTC_1847 st056231 15 µM 1.32388315552827 0.191453025759798 no 704 0.092770926654319 122 5393180
SGTC_2221 6807166 181.081 µM 1.32142162051125 0.191969207232934 no 705 0.0931804104826321 90 674925
SGTC_2971 9092186 9.93 µM 1.31709458558574 0.192878644436554 no 706 0.0939034608505697 116 25236400
SGTC_502 l-744,832 89.3 µM 1.31534967786041 0.193246124846579 no 707 0.094196204750014 112 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_1164 k060-0068 93.7 µM 1.31488696385356 0.193343644806414 no 708 0.0942739472856531 120 5963676
SGTC_1821 st053465 65.6 µM 1.31448207929159 0.193429001467729 no 709 0.0943420124653104 103 675086
SGTC_3346 9158254 43.5805 µM 1.31156431798129 0.194044795516062 no 710 0.0948335895142784 143 17639500
SGTC_112 phenothiazine 287.218 µM 1.30993430132998 0.194389330241667 no 711 0.0951090309906836 118 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_3123 9126162 49.47 µM 1.30630348205246 0.195158109859364 no 712 0.0957246867272598 109 25239884
SGTC_3116 9124943 49.47 µM 1.30240322101909 0.195985995736605 no 713 0.096389291036597 111 41905195 YPL160W CDC60
SGTC_1474 0330-0125 5.35 µM 1.30058234354832 0.196373231311782 no 714 0.0967007269626358 113 X1474
SGTC_2254 7938975 95.19 µM 1.29902486709649 0.196704818607672 no 715 0.0969676976752003 112 2969277
SGTC_1786 berberine 21.6 µM 1.29762678531397 0.197002759375214 no 716 0.0972078066706328 145 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 1.29457072981959 0.197654976075022 no 717 0.0977341775435924 136 688664
SGTC_1702 st027038 51 µM 1.29348638103173 0.197886708760145 no 718 0.0979214456733757 112 5521182
SGTC_2802 7925815 54.55 µM 1.29241740143443 0.198115317521743 no 719 0.0981063168106905 127 1262923
SGTC_50 0929-0078 56.389 µM 1.29119881284447 0.19837611561884 no 720 0.0983173733359593 108 1377751
SGTC_2649 anisomycin 9.56 µM 1.28795399901769 0.19907156895866 no 721 0.0988809883163221 132 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_312 4092-0653 6.84 µM 1.28702260580278 0.199271463294561 no 722 0.0990432045095828 148 1148278
SGTC_282 k297-0036 65.7 µM 1.28356843317166 0.200013847855324 no 723 0.0996465003810834 125 5061378
SGTC_2288 7946289 167.31 µM 1.27657774988175 0.2015213922845 no 724 0.100875680664827 128 1246052
SGTC_2091 4-phenylthiadiazole 200 µM 1.27628705237986 0.201584228439066 no 725 0.100927032714217 118 270010
SGTC_3151 9099821 49.47 µM 1.27496181422913 0.201870835976472 no 726 0.101161379058284 134 17174189
SGTC_899 1083-0020 478 µM 1.27450731764705 0.201969185518097 no 727 0.101241840473771 140 767123
SGTC_1866 st057638 64 µM 1.2738063873049 0.202120917628121 no 728 0.101366020476765 83 688802
SGTC_31 0508-1974 57.237 µM 1.27251185893988 0.202401326606495 no 729 0.101595656637068 104 6810525
SGTC_1963 st076565 50.3 µM 1.27196316878414 0.202520249047206 no 730 0.101693102915096 147 4914280
SGTC_2774 tamoxifen 10.92 µM 1.27073458298438 0.202786682684722 no 731 0.101911544045912 124 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_1289 0976-0073 69.1 µM 1.27002675308438 0.202940279167349 no 732 0.10203755032873 128 3391136
SGTC_734 2023-0417 80 µM 1.26941696124265 0.203072657449957 no 733 0.102146194964611 147 3935732
SGTC_2144 5628481 200 µM 1.2681293271525 0.203352356240943 no 734 0.102375884979382 93 2818399
SGTC_3350 9150499 3.57 µM 1.26531054788884 0.203965450927892 no 735 0.102880013457192 132 4910996 YPR165W RHO1
SGTC_1836 st055642 81 µM 1.26458138655506 0.204124225281002 no 736 0.103010714466897 159 8571
SGTC_3330 9141424 71.43 µM 1.26251072617359 0.204575511278659 no 737 0.103382534559531 105 27261020
SGTC_967 1306-0166 352 µM 1.26228980230491 0.204623695120176 no 738 0.103422262407859 145 4437607
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 1.26222321722779 0.204638218753792 no 739 0.103434238306742 114 6857784
SGTC_1369 1866-0067 208 µM 1.26066731488285 0.204977769001618 no 740 0.103714367356576 132 3531355
SGTC_252 miconazole 1.30953 nM 1.25901597182151 0.20533851375656 no 741 0.104012281478264 158 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1163 k060-0048 49.9 µM 1.25887517640238 0.20536928870896 no 742 0.104037710659868 125 6809982
SGTC_2384 9036245 200 µM 1.25703586930941 0.205771574608927 no 743 0.104370323675815 101 6462766
SGTC_1315 1237-0019 3.69 µM 1.25698409519893 0.205782905197883 no 744 0.104379697439088 123 825140
SGTC_2690 usnic acid 100 µM 1.25638709026345 0.205913584453469 no 745 0.104487829959568 123 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_391 gliotoxin 8.33 µM 1.25616977539915 0.205961165030082 no 746 0.10452721125652 134 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_27 0485-0001 32.618 µM 1.25074251743183 0.207151564130371 no 747 0.105514216467727 125 2054479
SGTC_838 0109-0203 71.4 µM 1.24866212417474 0.207608948420588 no 748 0.105894339832251 125 759422
SGTC_3138 9097216 49.47 µM 1.24809370989609 0.207734020703016 no 749 0.105998370764368 142 25237486
SGTC_1387 3342-1166 1.8 µM 1.247608025394 0.207840924612987 no 750 0.10608731902138 110 3418228
SGTC_1833 st055984 71 µM 1.24572927500048 0.208254761762271 no 751 0.10643190110714 125 676288
SGTC_1902 st060212 70.5 µM 1.24320101692849 0.208812434268975 no 752 0.106896884038734 131 688944
SGTC_2023 5144124 124 µM 1.24149521764409 0.209189188905402 no 753 0.107211431878657 128 2830192
SGTC_2680 butyl paraben 22.24 µM 1.24140260077626 0.209209656355545 no 754 0.107228529426513 146 7184 An antifungal and steroid mimetic.
SGTC_1415 3966-0071 78.1 µM 1.24062311772432 0.209381961431177 no 755 0.107372503893044 125 2893185
SGTC_1074 carmofur 3.8 µM 1.24013592192959 0.209489698674035 no 756 0.107462562160802 149 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1849 st056239 19.2 µM 1.23879637533028 0.209786090671534 no 757 0.107710458288142 130 5393181
SGTC_573 3702-0553 84.7 µM 1.23875277745495 0.209795741405569 no 758 0.10771853341565 145 1222756
SGTC_1979 st071809 45.3 µM 1.23508984520907 0.210607492116815 no 759 0.108398534140125 137 4976333
SGTC_2603 homopterocarpin 100 µM 1.2345908255941 0.2107182234476 no 760 0.108491412580815 135 101795 A weak amylase inhibitor.
SGTC_185 k048-0037 25.491 µM 1.23454202365707 0.210729054320715 no 761 0.108500498758689 114 6827589
SGTC_69 0096-0274 206.684 µM 1.23283017881568 0.211109179729911 no 762 0.108819564687526 197 6741392
SGTC_1439 4092-1168 46 µM 1.23258899908102 0.21116276741509 no 763 0.108864571661061 137 2886240
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 1.2293980563154 0.211872512529742 no 764 0.109461299329617 173 368090
SGTC_91 0417-1751 58.384 µM 1.22859987794348 0.212050265237003 no 765 0.109610930641238 147 6795624
SGTC_41 0478-0632 82.643 µM 1.22723633982754 0.212354124069251 no 766 0.109866887323807 148 3750424
SGTC_1904 st060225 78 µM 1.22596793230787 0.212637011741 no 767 0.110105371407159 129 66595
SGTC_1957 st077035 62.4 µM 1.22578220216767 0.212678452827873 no 768 0.11014032325675 139 705593
SGTC_1563 conessine 56.1 µM 1.2248912107819 0.212877321084391 no 769 0.110308106213601 96 441082 An anti-amoebic, histamine inhibitor.
SGTC_1750 st081859 2.357 µM 1.222506592341 0.213410098820305 no 770 0.110758056225302 171 5291695
SGTC_3282 9108498 15.4605 µM 1.22041397682381 0.213878276160654 no 771 0.111153990786993 140 16459645
SGTC_788 1182-0090 188 µM 1.2203418766025 0.213894417671748 no 772 0.111167650590078 139 5715185
SGTC_1444 4112-3581 28 µM 1.21858767923032 0.214287358917192 no 773 0.111500363854239 141 2877249
SGTC_2572 astragaloside iv 100 µM 1.21820007118006 0.214374239956264 no 774 0.111573976313993 138 45006101 An anti-inflammatory agent.
SGTC_746 1095-0025 46.6 µM 1.21793043860808 0.214434689269292 no 775 0.111625204002314 148 6749286
SGTC_677 0929-0063 136 µM 1.21661175849277 0.214730468795364 no 776 0.111875983395413 124 1539583
SGTC_321 4534-3890 65.3 µM 1.2146855748805 0.215162936933287 no 777 0.112243018178929 146 699746
SGTC_817 1391-0715 46 µM 1.21225401566626 0.215709593687415 no 778 0.112707580210283 166 1353946
SGTC_2116 5511452 16.8835 µM 1.21170919567215 0.215832189008724 no 779 0.112811858920489 150 870744
SGTC_1071 trifluoperazine 6.31 µM 1.21027950215058 0.216154090400015 no 780 0.113085830185779 149 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_1078 idebenone 36.1 µM 1.20871798369122 0.216505990176357 no 781 0.113385605100104 169 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_332 4112-0506 40.9 µM 1.20856805663754 0.216539794783457 no 782 0.11341441737071 169 2790355
SGTC_2261 9010538 184.68 µM 1.20794582925642 0.216680123323674 no 783 0.113534049882773 132 6457250
SGTC_2556 citropten 84.59 µM 1.20676437903831 0.216946715929234 no 784 0.113761448904866 114 2775 A potential DNA crosslinker.
SGTC_188 3229-0966 278.469 µM 1.20235751172993 0.217942790344413 no 785 0.114612521687768 179 5722370
SGTC_1306 1185-0270 9.02 µM 1.20180722457522 0.218067355462479 no 786 0.114719112860823 149 1548076
SGTC_1131 3454-3128 32.3 µM 1.20119079051536 0.218206942572531 no 787 0.114838600496548 138 710982
SGTC_2868 9035608 32.47 µM 1.2004155243388 0.218382569162363 no 788 0.114989001305539 126 6462614
SGTC_2230 bromochlorosalicylanilide 954.5 nM 1.19860234850712 0.218793638590668 no 789 0.115341302287458 115 77254
SGTC_3132 9126706 49.47 µM 1.19728123543062 0.21909343148705 no 790 0.115598477890012 160 850858
SGTC_962 1254-0300 21.5 µM 1.19531623077576 0.219539775792806 no 791 0.11598175034229 133 7340576
SGTC_3169 9102970 49.47 µM 1.19282197788117 0.220107088631341 no 792 0.116469550391426 138 17027839
SGTC_1784 st039334 36.3 µM 1.18968938242937 0.220820781029951 no 793 0.117084250025213 157 3496984
SGTC_1777 st045864 34.765 µM 1.18788665513486 0.221232092422766 no 794 0.117439033973115 167 4691462
SGTC_3046 9092212 49.47 µM 1.18783555259322 0.221243758394819 no 795 0.11744910224116 137 25236637
SGTC_756 0508-1999 28.3 µM 1.18607524962198 0.221645824903154 no 796 0.117796291891509 152 6753853
SGTC_2557 derrustone 83.84 µM 1.1844914440435 0.222007934644335 no 797 0.11810929058831 150 629853 An antioxidant.
SGTC_35 0133-0054 64.071 µM 1.18183004754866 0.222617176900533 no 798 0.118636571355473 158 99677
SGTC_2790 5423970 71.43 µM 1.17709471343879 0.223703534498332 no 799 0.119578852461035 161 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_972 1319-0219 195 µM 1.17424759056612 0.224358156007801 no 800 0.120147934447283 162 23903702
SGTC_2296 7971656 126.45 µM 1.17300503193049 0.224644190376358 no 801 0.120396893909372 128 666570
SGTC_1109 tnp00067 928.257 nM 1.17007597409947 0.225319271143534 no 802 0.120985198082732 118 676295
SGTC_2192 5915882 198.485 µM 1.16716920258909 0.225990349672238 no 803 0.121571022734777 142 2876149
SGTC_2024 5144227 134 µM 1.16706890443838 0.226013525385773 no 804 0.12159127213717 138 3475211
SGTC_2351 9026858 72.31 µM 1.16512745773628 0.226462396609817 no 805 0.121983701964045 158 1409300
SGTC_2972 9093619 59.92 µM 1.16489511799152 0.226516148310369 no 806 0.122030724949516 115 25236256
SGTC_1465 k213-0056 144 µM 1.16337198978549 0.22686870170639 no 807 0.122339304466819 168 24048857 YMR208W ERG12
SGTC_885 0865-0106 16.8 µM 1.1621545901663 0.227150711554606 no 808 0.122586338140378 139 2793380
SGTC_2273 7815444 169.05 µM 1.16115835705635 0.227381635262121 no 809 0.122788753106148 163 2824616
SGTC_3055 9094636 49.47 µM 1.16082956241809 0.22745787784452 no 810 0.122855609125165 179 25236176
SGTC_1971 st069429 63.5 µM 1.1591218638998 0.2278540992393 no 811 0.123203257491878 133 1246522 YGL099W LSG1
SGTC_646 4092-0839 27.3 µM 1.15643136979599 0.228479136780557 no 812 0.12375237824022 161 877796
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 1.15635338138135 0.228497268879827 no 813 0.123768320924993 141 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_1764 st044502 93.5 µM 1.15623719496768 0.228524283411605 no 814 0.123792074854883 141 8407
SGTC_3117 9124945 49.47 µM 1.15531599497379 0.228738535343257 no 815 0.12398052412964 117 17592065
SGTC_538 2922-0838 53.3 µM 1.15370853136722 0.229112667850368 no 816 0.124309842520385 167 777039
SGTC_1579 chlormadinone acetate 49.4 µM 1.15171055780469 0.229578168498437 no 817 0.124720016168303 156 45114258 A steroidal progestin.
SGTC_313 3474-0040 5.03 µM 1.15170946315642 0.229578423681732 no 818 0.124720241152882 171 1043375 YIL048W NEO1
SGTC_3291 9121177 71.43 µM 1.15136210704391 0.229659407012333 no 819 0.124791648063413 134 17015612
SGTC_1513 0337-0559 19 µM 1.1507570210625 0.229800516230254 no 820 0.12491610539982 137 775073
SGTC_1266 0828-0227 32.9 µM 1.14896001108401 0.230219874409187 no 821 0.125286235159604 154 3913820
SGTC_1281 0884-0031 11.8 µM 1.14845542291065 0.230337704256365 no 822 0.125390302621293 155 1548255
SGTC_3057 9095946 49.47 µM 1.14832193803489 0.230368880865154 no 823 0.125417842948311 164 24540043
SGTC_2375 9072683 200 µM 1.14706220963075 0.230663218080082 no 824 0.125677955483244 160 16798029
SGTC_2488 5268135 45.7 µM 1.14347915955666 0.231501550121503 no 825 0.126419851323041 174 1270356 YLR208W SEC13
SGTC_653 0203-0016 55.2 µM 1.14346132884479 0.231505726245315 no 826 0.126423550912007 162 295302
SGTC_258 haloperidol 50.781 µM 1.14338451077568 0.231523718254424 no 827 0.126439490301423 173 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_519 k048-0011 62.8 µM 1.14329933228829 0.231543669317328 no 828 0.126457166075373 154 6836379
SGTC_2928 9011484 9.79 µM 1.14233418421776 0.23176979955674 no 829 0.126657568594121 176 2994751
SGTC_447 ml7 120 µM 1.13313355877421 0.233931634409651 no 830 0.128579085230256 132 4216 Selective myosin light chain kinase inhibitor.
SGTC_1719 st032227 49.2 µM 1.13287522483722 0.233992494936249 no 831 0.128633327748429 148 3125804
SGTC_2385 9074692 200 µM 1.13206606265778 0.234183181058763 no 832 0.12880333072753 135 17046906
SGTC_2757 clomiphene 4.22 µM 1.13174528651173 0.23425879856214 no 833 0.128870768127213 186 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_2165 5727197 32.143 µM 1.12979661362299 0.234718455281022 no 834 0.129280967735256 161 1361712
SGTC_1457 k015-0032 57.3 µM 1.12859213930003 0.235002818194119 no 835 0.129534964115965 152 4302660
SGTC_2186 6124449 200 µM 1.12727479996107 0.235314045078978 no 836 0.129813156766061 157 3834182 YLR033W RSC58
SGTC_1914 st062367 72.6 µM 1.12490929742798 0.235873475558555 no 837 0.130313735874032 161 978205
SGTC_1533 dihydroergotamine mesylate 29.4 µM 1.12356391579358 0.236191978904506 no 838 0.130599035659914 193 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_3238 9133470 49.47 µM 1.12171490971355 0.236630095657487 no 839 0.130991837553814 131 3534688
SGTC_1989 st071868 50.2 µM 1.12094187173508 0.236813397265802 no 840 0.13115630307851 163 16414057
SGTC_835 0312-0010 67.2 µM 1.11853138611306 0.237385469012133 no 841 0.13167005472891 168 1626196
SGTC_839 0122-0028 230 µM 1.11722687344162 0.237695380389816 no 842 0.131948666532585 206 759448
SGTC_1677 st019204 53.9 µM 1.11663011135949 0.237837226342513 no 843 0.13207625568482 137 3945625
SGTC_1978 st071761 42 µM 1.11648069571715 0.237872748605572 no 844 0.132108214416987 161 5147680
SGTC_275 trichlorophene 5.69 µM 1.11613685578146 0.237954504594708 no 845 0.132181779100902 148 62616
SGTC_744 1594-0068 283 µM 1.11562983202414 0.238075089456829 no 846 0.132290308545173 167 668392
SGTC_923 1900-2434 73.3 µM 1.11488939144316 0.238251247717164 no 847 0.132448911646009 178 5910570
SGTC_1493 4348-0038 111 µM 1.1146891741179 0.238298893693751 no 848 0.132491820890741 194 800424
SGTC_3207 9114163 49.47 µM 1.11373806163469 0.238525302433007 no 849 0.132695787809387 180 849233
SGTC_2777 climbazole 1.536 µM 1.10918815296371 0.239610018328342 no 850 0.133674511131454 164 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_787 4152-0075 138 µM 1.10763764553503 0.239980279512637 no 851 0.134009169240864 154 9566539
SGTC_783 0848-0141 92.7 µM 1.10561783444711 0.240463077988438 no 852 0.134445983597965 177 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_3083 9117465 49.47 µM 1.1055682783993 0.240474930089709 no 853 0.134456713106702 154 16420915
SGTC_2943 9068529 45.32 µM 1.10348709115635 0.240972965576013 no 854 0.134907847192475 195 3270634
SGTC_2285 7945142 200 µM 1.10009597664588 0.241785671597805 no 855 0.135645153328838 157 2970608
SGTC_2582 agaric acid 100 µM 1.09926494725769 0.241985060705336 no 856 0.135826258527897 189 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_1912 st060209 90.8 µM 1.09845748063971 0.242178881786074 no 857 0.136002387267552 166 688787
SGTC_2534 helenine 20.12 µM 1.09621710084477 0.242717094071373 no 858 0.136491888816568 165 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_1613 st002381 52.1 µM 1.09415902908098 0.243212080059843 no 859 0.136942618523144 159 551167
SGTC_202 3594-0513 34.79 µM 1.08998251955232 0.244218245791112 no 860 0.137860422150717 155 708429
SGTC_370 0180-0345 38.7 µM 1.08857883833076 0.244556910755667 no 861 0.138169826437129 145 3989527
SGTC_3139 9095020 49.47 µM 1.08688388668477 0.244966187200342 no 862 0.138544064161517 131 25236292
SGTC_518 1021-0119 62.6 µM 1.08579255367767 0.245229904014107 no 863 0.138785390780577 182 1097762
SGTC_1249 0481-0015 10.2 µM 1.0846715811353 0.245500941954644 no 864 0.13903356948895 178 4227577
SGTC_2297 7971671 152.32 µM 1.08413042540667 0.245631844606637 no 865 0.139153487203046 168 909016
SGTC_1300 1094-0077 113 µM 1.08128782501825 0.246320069497591 no 866 0.139784550734876 163 5532636
SGTC_3201 9113999 49.47 µM 1.07678879545692 0.247411443408481 no 867 0.140787316039681 151 16649224
SGTC_997 3996-0078 137 µM 1.07669244728823 0.247434843764652 no 868 0.140808843829965 168 735687
SGTC_1728 st035614 33.7865 µM 1.07509767123901 0.247822343356334 no 869 0.141165500992582 183 15945546
SGTC_613 3914-0030 117 µM 1.0744045640342 0.24799085587967 no 870 0.141320698907274 127 1145395
SGTC_2055 5235184 200 µM 1.07254264988075 0.248443838566028 no 871 0.141738184088115 164 2836034
SGTC_3136 9095672 49.47 µM 1.07252669479716 0.24844772216229 no 872 0.141741765201145 161 17217380
SGTC_925 2064-1272 59.6 µM 1.07234039701178 0.248493070942721 no 873 0.141783584210356 168 6815817
SGTC_3030 9087619 49.47 µM 1.07073851144534 0.248883185365823 no 874 0.14214351068556 184 25236973
SGTC_941 3237-0776 460 µM 1.06844534243016 0.249442218044186 no 875 0.142659836527391 159 760008
SGTC_831 k061-1017 217 µM 1.0683821815516 0.249457624949379 no 876 0.142674075639937 187 1240153
SGTC_189 3970-0742 2.116 µM 1.06788794956757 0.249578200980533 no 877 0.142785529447081 166 2891807
SGTC_1451 4152-0210 104 µM 1.06373897206065 0.250591632114372 no 878 0.143723482217786 174 659563
SGTC_1868 st057644 42.7 µM 1.0634079204891 0.250672588729879 no 879 0.143798501216534 156 688665
SGTC_1242 0402-0103 60.1 µM 1.05683981655494 0.252281637489923 no 880 0.145292349569439 169 432868
SGTC_414 piperonyl butoxide 100 µM 1.05654044075495 0.252355107873392 no 881 0.145360687440472 174 5794 A potent inhibitor of cytochrome P450.
SGTC_1129 3453-1384 223 µM 1.05506318974965 0.252717807922799 no 882 0.145698212902807 177 1084452
SGTC_2909 7941780 10.49 µM 1.05467804865394 0.252812414262336 no 883 0.145786297281634 169 1243215
SGTC_3327 9140648 26.9345 µM 1.0499541093631 0.253974321335021 no 884 0.146869606067906 213 8029710
SGTC_2439 5492030 7.2 µM 1.04799471473874 0.254457077786155 no 885 0.147320520983136 169 5722370
SGTC_2280 7785178 200 µM 1.04710886755661 0.254675490909384 no 886 0.147524684973954 163 2954328
SGTC_3332 9141069 11.198 µM 1.04708761816501 0.254680731332301 no 887 0.147529584715049 162 17332883
SGTC_1018 4259-0013 28.1 µM 1.04642272608131 0.254844732347401 no 888 0.147682952371276 167 6801262
SGTC_1212 0520-0165 585 µM 1.04633420778282 0.254866570271103 no 889 0.147703378539033 174 5403258
SGTC_1037 k284-1091 78.7 µM 1.04547900742895 0.255077603068808 no 890 0.147900818970739 170 3334711
SGTC_2218 6965428 192.983 µM 1.04373360259579 0.255508589895777 no 891 0.148304329311864 160 675684
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 1.04284788898283 0.255727441542207 no 892 0.148509373876091 171 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_3164 9100705 49.47 µM 1.04210835900632 0.255910247509437 no 893 0.148680721771661 134 17174235
SGTC_3306 9127676 59.7925 µM 1.03310383748065 0.258141552210661 no 894 0.150777653849059 161 41905287
SGTC_1860 st056228 74.6 µM 1.03086259167332 0.258698492683631 no 895 0.151302630589163 194 688679
SGTC_3130 9127414 49.47 µM 1.03040373446918 0.258812593493652 no 896 0.151410260454541 173 1494646
SGTC_362 0310-0100 9.03 µM 1.0278428075386 0.259449879196016 no 897 0.152011888075258 160 790235
SGTC_2400 5203494 178.7 µM 1.02695287151253 0.259671529058749 no 898 0.152221328197877 185 6777674
SGTC_1692 fluoroquinolonic acid 71 µM 1.02439748985539 0.260308522134449 no 899 0.15282378355157 176 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_2369 9071472 200 µM 1.02425170837756 0.260344886089382 no 900 0.152858200522989 155 17296037
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 1.02171619680788 0.260977766287523 no 901 0.153457621465814 178 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_1001 4048-4355 44.4 µM 1.02000660138375 0.261404938528558 no 902 0.15386266497899 190 21824233
SGTC_2321 7390090 138.78 µM 1.01920377057025 0.261605663647095 no 903 0.15405311848445 153 649046
SGTC_3217 9129673 49.47 µM 1.01878880199405 0.261709445796357 no 904 0.154151621538049 180 17248312
SGTC_1297 1068-0111 14.1 µM 1.01842069932015 0.261801524629711 no 905 0.154239034672609 178 767057
SGTC_1730 st033808 45.1 µM 1.01835499245689 0.261817962583288 no 906 0.154254641491829 175 1045166
SGTC_837 0091-0265 12.5 µM 1.0174619993592 0.26204141606152 no 907 0.154466850455408 194 759367
SGTC_2497 7-hydroxyflavone 100 µM 1.01695170932131 0.262169149709812 no 908 0.154588201293765 201 5281894
SGTC_385 1494-0393 12.4 µM 1.01454713933823 0.262771480599507 no 909 0.155160874018928 186 3090647
SGTC_2834 9001755 58.44 µM 1.01327486171228 0.263090464886719 no 910 0.155464445677416 174 2989575
SGTC_1681 tripelennamine 100 µM 1.01294448578822 0.263173328787556 no 911 0.155543339034588 152 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_1923 st058458 19.1 µM 1.01164539807166 0.263499291324862 no 912 0.155853815618505 207 3534982
SGTC_3301 9125354 19.7965 µM 1.00951802473653 0.264033529035648 no 913 0.156363130826903 167 41905162
SGTC_270 tamoxifen 5.46 µM 1.00937428862885 0.264069644734254 no 914 0.156397582230096 196 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_2342 7990637 118.86 µM 1.00558036278742 0.265023830577359 no 915 0.157308737023657 196 2033102 YER133W GLC7
SGTC_285 1486-1325 46 µM 1.00423352223165 0.265362986576561 no 916 0.157633033868946 194 22310230
SGTC_3309 9129340 25.759 µM 1.00300289386866 0.265673070962808 no 917 0.157929732494732 179 17158987
SGTC_1186 1319-0216 26 µM 1.00077855141525 0.266234009660805 no 918 0.158466940615772 186 4565136
SGTC_1113 artemisinin 1.17947 µM 0.996904737026777 0.267212344328325 no 919 0.159405376072572 218 2240 An anti-malaria and mitochondrial poison.
SGTC_1696 st025591 34.7925 µM 0.996045985837109 0.267429468012297 no 920 0.159613901111016 163 2787147
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.995873758431818 0.26747302410459 no 921 0.159655743468388 196 688788
SGTC_144 4161-2749 112.381 µM 0.995376221306153 0.267598870704433 no 922 0.159776659588712 201 797501 YMR168C CEP3
SGTC_344 k064-0035 6.43 µM 0.993242381014454 0.268138940684313 no 923 0.160295924698007 187 5088750
SGTC_797 k781-0471 270 µM 0.993083688328511 0.268179127335714 no 924 0.160334586210626 205 23738129
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.992918324559397 0.268221006567817 no 925 0.160374879449132 202 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1069 diphenylcyclopropenone 8.49 µM 0.991890556916347 0.268481367812689 no 926 0.160625458031008 201 65057 A dermal irritant. YDR527W RBA50
SGTC_1321 1326-2144 215 µM 0.98954563643243 0.269075874645816 no 927 0.16119812655694 195 3513030
SGTC_2674 ligustilide 100 µM 0.989188670296859 0.269166434044679 no 928 0.161285420292578 185 5319022 A signalling regulator.
SGTC_1435 4092-0789 56.7 µM 0.988962517791519 0.269223815003224 no 929 0.161340740362761 202 2248285
SGTC_2414 st077232 92.9 µM 0.988860120564264 0.269249797945146 no 930 0.161365792228436 154 729801
SGTC_1401 3807-4679 7.6 µM 0.983512566988262 0.270608466668951 no 931 0.162677616657938 197 3291456
SGTC_2012 4023501 200 µM 0.980522667834447 0.271369608906551 no 932 0.163414092983643 212 3477460
SGTC_277 nystatin 15.5 µM 0.97879869990175 0.271808965871841 no 933 0.163839726116425 182 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_430 0958-0115 16.4 µM 0.978338843438327 0.271926221062544 no 934 0.163953382242374 180 6833180
SGTC_948 3448-0295 75.3 µM 0.976638061384732 0.272360108632006 no 935 0.164374184522483 190 678569
SGTC_878 0828-0289 13.7 µM 0.975856593947281 0.272559584526106 no 936 0.164567767360727 190 745350 YLR208W SEC13
SGTC_1857 st056007 79.3 µM 0.974870730344873 0.272811337619083 no 937 0.164812193295771 175 619834
SGTC_3090 9117696 49.47 µM 0.97400018417059 0.273033738766613 no 938 0.165028223889702 172 7923821
SGTC_78 0336-0123 156.75 µM 0.973005538141369 0.27328795404979 no 939 0.165275274812027 174 6765896
SGTC_2643 anethole 100 µM 0.971681279569455 0.273626594768503 no 940 0.165604566393413 201 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_1900 st060200 72.8 µM 0.97098667873949 0.273804301758746 no 941 0.165777456116306 187 688945
SGTC_3286 9117135 37.221 µM 0.966924167677923 0.274844798058839 no 942 0.166790972030679 205 3438150
SGTC_991 3996-0057 64.7 µM 0.965533431558637 0.27520144269483 no 943 0.16713884969651 173 715343
SGTC_1287 0971-0001 34.6 µM 0.964923549976495 0.2753579144347 no 944 0.167291552451931 183 4665869
SGTC_2063 5246145 200 µM 0.964795033430152 0.275390892333439 no 945 0.167323742019185 202 711240
SGTC_176 1486-1328 72.834 µM 0.962614134900985 0.27595081639826 no 946 0.167870600707784 183 22310231
SGTC_554 4483-2211 187 µM 0.962301406044171 0.27603115224573 no 947 0.167949111455538 176 747107
SGTC_1326 1431-2094 10.8 µM 0.956856237736967 0.277431780845643 no 948 0.1693199111355 196 616278
SGTC_305 1682-2595 20.8 µM 0.956422449139034 0.27754351097049 no 949 0.169429423708361 202 226033
SGTC_2588 indole-3-carbinol 100 µM 0.955178534937323 0.277864025524268 no 950 0.169743709416951 193 3712 Induces cell cycle arrest.
SGTC_3283 9109332 35.8195 µM 0.954117518618321 0.278137556203297 no 951 0.17001207966627 172 17027281
SGTC_2783 7738165 71.43 µM 0.954030077474069 0.278160104441959 no 952 0.170034208888117 191 17201110
SGTC_1477 0139-0234 16 µM 0.95148960563803 0.278815598756815 no 953 0.170677946294656 193 620880
SGTC_1094 duloxetine 25.4 µM 0.951005608143883 0.278940565328212 no 954 0.170800764491853 186 60834 A selective serotonin reuptake inhibitor.
SGTC_2845 9003024 42.97 µM 0.950714278267179 0.279015798884682 no 955 0.170874719016516 185 2990173
SGTC_3017 9080681 49.47 µM 0.949667096795006 0.279286306391647 no 956 0.171140716756576 191 16451914
SGTC_1261 0712-0010 12.7 µM 0.948936181072797 0.279475191741459 no 957 0.171326535709027 196 2840123
SGTC_815 1582-0027 36.9 µM 0.94883373732734 0.27950167050576 no 958 0.171352590038604 215 3128206
SGTC_1150 3909-7983 10.9 µM 0.946405648569252 0.280129618029247 no 959 0.171970862729823 214 23965914
SGTC_946 3434-1334 87.4 µM 0.944068820274947 0.280734608826249 no 960 0.1725672406659 192 4047976
SGTC_356 1634-0012 32.5 µM 0.943568923909997 0.2808641109919 no 961 0.172694989389908 216 735457
SGTC_2356 9061756 188.97 µM 0.943520599770765 0.280876631278698 no 962 0.172707341838634 192 20104043
SGTC_1475 4092-1048 11.7 µM 0.942900348004542 0.281037356074946 no 963 0.172865938448908 191 2881759
SGTC_2601 securinine 100 µM 0.939233383896023 0.281988477175287 no 964 0.173805466203165 245 442872 A GABA receptor antagonist.
SGTC_2267 7931562 200 µM 0.937622480488703 0.282406795839614 no 965 0.174219227150475 174 934880
SGTC_3168 9103419 49.47 µM 0.936958858070397 0.282579211773791 no 966 0.174389860637552 198 16649256
SGTC_2102 5377816 72.7585 µM 0.936767415703182 0.282628959873903 no 967 0.174439104857872 204 1379702
SGTC_3211 9128781 49.47 µM 0.936393114406072 0.282726237746326 no 968 0.174535410918334 187 17194361
SGTC_2831 7999036 19.48 µM 0.932828237831394 0.283653525598419 no 969 0.175454329526418 197 2988270
SGTC_694 1315-0438 43.2 µM 0.93204813382595 0.283856638647517 no 970 0.175655825264337 194 6793154
SGTC_1501 4491-0275 38.4 µM 0.931950444727687 0.283882078532787 no 971 0.175681068042417 205 5104718
SGTC_1562 morin hydrate 59.1 µM 0.931656786729389 0.28395855858796 no 972 0.175756962851937 193 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_537 1334-0398 209 µM 0.930417831872667 0.28428133950911 no 973 0.176077394718308 205 5846986
SGTC_1645 Cervolide 78 µM 0.929454948463415 0.284532317482515 no 974 0.17632668124657 207 23173 A fragrance.
SGTC_3324 9138759 60.749 µM 0.927457388402988 0.285053323755871 no 975 0.176844553066876 189 45595710
SGTC_2386 9075165 157.42 µM 0.927332648605913 0.285085873638608 no 976 0.176876923992118 196 16452277
SGTC_2605 digitonin 300 nM 0.92636581088147 0.285338222517086 no 977 0.177127952718907 221 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_3026 9090633 49.47 µM 0.925588973413146 0.285541057553482 no 978 0.17732981295307 202 25236842
SGTC_2822 7994718 71.43 µM 0.925282590412526 0.285621074116606 no 979 0.177409466114598 227 1018011
SGTC_2446 5162541 200 µM 0.924750925795113 0.28575995170569 no 980 0.177547741374552 203 1549321
SGTC_1455 4262-0120 131 µM 0.923265496881772 0.286148134845907 no 981 0.177934431903417 190 1529587
SGTC_2131 toluylene red 5.2905 µM 0.921654337868735 0.286569457670961 no 982 0.178354452766458 171 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_2719 novobiocin 32.65 µM 0.921049340146634 0.286727742316342 no 983 0.178512333761259 202 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_1521 st012942 49.4 µM 0.918611549233592 0.287365957525737 no 984 0.179149394466629 191 24207259
SGTC_563 tetrahydrosecaminediol 614 µM 0.916366702506424 0.287954253519324 no 985 0.179737296785894 185 334274 A psychoactive constituent of the cannabis plant.
SGTC_117 lucigenin 22.078 µM 0.915193667196519 0.288261891166276 no 986 0.180044984309575 206 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_1694 st024011 44.9 µM 0.913949545120444 0.288588341156474 no 987 0.180371679058444 213 2787533
SGTC_165 k038-0023 64.381 µM 0.91256387730414 0.288952136763764 no 988 0.180735979903426 192 46368543
SGTC_3128 9127691 49.47 µM 0.910740638811648 0.289431141412468 no 989 0.181216023110169 198 41316314
SGTC_308 4092-1169 104 µM 0.909950988481494 0.2896387155294 no 990 0.181424178931355 214 2268590 YDL196W YDL196W
SGTC_232 clozapine 119 µM 0.908813556638073 0.289937833178291 no 991 0.18172427469318 199 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_1361 1608-0041 5.61 µM 0.908458695708258 0.29003118283949 no 992 0.181817963397151 227 X1361
SGTC_1520 flindersine 88 µM 0.906582390325687 0.290524997482233 no 993 0.182313838741432 214 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_461 N-acetylfarnesylcysteine 136 µM 0.90389665118641 0.291232526501439 no 994 0.183025102529737 229 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_2635 hydroquinidine 100 µM 0.903299041751102 0.291390069602677 no 995 0.183183602491545 181 442912 An experimental heart treatment.
SGTC_1910 st062352 60.4 µM 0.903263070374424 0.291399553723979 no 996 0.183193145670594 201 2245730
SGTC_735 3076-0345 636 µM 0.901718138311218 0.291807022421638 no 997 0.183603307594961 217 2888990
SGTC_1031 k035-0009 16 µM 0.900351229798486 0.292167759413186 no 998 0.18396668304963 211 5180959
SGTC_1962 st076595 64.5 µM 0.900289874966932 0.292183956259652 no 999 0.183983003955264 212 279619
SGTC_2907 7721985 69.9 µM 0.898325797521374 0.292702666770457 no 1000 0.184505941513068 186 3267881
SGTC_2552 juarezic acid 87.02 µM 0.897024852413858 0.293046480114453 no 1001 0.184852827876589 190 1549512
SGTC_1309 pyrazolanthrone 13.4 µM 0.896655478354419 0.293144132304722 no 1002 0.184951392279025 214 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_2403 6032726 181.2 µM 0.895998381725925 0.293317887599735 no 1003 0.185126813763958 194 2881040
SGTC_2634 4'-methoxyflavone 100 µM 0.89366417924545 0.293935503625272 no 1004 0.185750798229398 181 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_1009 4106-0057 9.87 µM 0.891037293938251 0.294631280114375 no 1005 0.186454581615895 221 2928005
SGTC_1559 coumarin 343 70.1 µM 0.885788739440977 0.296023722092364 no 1006 0.187865689438453 205 108770 A hepatotoxic, DNA x-linker.
SGTC_3268 9137683 49.47 µM 0.885271119471293 0.296161210205738 no 1007 0.188005211280128 271 1953228
SGTC_830 4076-0286 57.8 µM 0.8826220816939 0.296865295036309 no 1008 0.188720246898028 216 6866659
SGTC_1473 k844-0725 134 µM 0.882412281350764 0.296921090360186 no 1009 0.188776948332517 229 54682906
SGTC_2734 clemastine 41.6 µM 0.882235898255531 0.296968002250877 no 1010 0.188824626418251 242 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_1130 3454-2858 15.9 µM 0.880224338611224 0.297503248208468 no 1011 0.189368895527639 234 715628 YIL048W NEO1
SGTC_2653 dihydrofissinolide 100 µM 0.879474048176439 0.297703002005174 no 1012 0.18957214914338 217 6857746
SGTC_1805 st050013 60.3 µM 0.872716722229702 0.2995047913336 no 1013 0.191408750370474 213 4037144
SGTC_3270 9137563 49.47 µM 0.869855114889281 0.30026930409416 no 1014 0.192189793648383 201 17015724
SGTC_415 dibenzyl ketone 100 µM 0.86985505250295 0.300269320771029 no 1015 0.19218981069725 225 7593
SGTC_94 0334-0113 514.748 µM 0.869823371982782 0.300277789537622 no 1016 0.192198468433847 228 6795178
SGTC_375 3970-0961 9.27 µM 0.869142138963752 0.300459921356616 no 1017 0.1923846953204 227 2898222
SGTC_1751 st044839 27.194 µM 0.868218874604019 0.300706841346499 no 1018 0.192637261712641 205 5291326
SGTC_1581 himbacine 57.9 µM 0.867398142250376 0.300926416791113 no 1019 0.192861949698903 218 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_1275 0867-0008 21.1 µM 0.862167409664768 0.302327521400294 no 1020 0.194297700468144 197 3422836
SGTC_1819 st053448 58.6 µM 0.861462847836436 0.302516468843475 no 1021 0.1944915873475 246 2857616
SGTC_2646 retinol 96.75 µM 0.861180234677424 0.30259227413208 no 1022 0.194569392145519 226 445354 A vitamin A analog and teratogen.
SGTC_2139 5578692 56.4705 µM 0.860885052751815 0.302671459827308 no 1023 0.194650677407634 232 650991 YMR113W FOL3
SGTC_1051 3253-3903 78 µM 0.859965038733319 0.302918322926574 no 1024 0.19490415735971 243 5509239
SGTC_72 0744-0168 198.391 µM 0.859701607039312 0.302989024926753 no 1025 0.194976774348735 229 677577
SGTC_460 trequinsin 123 µM 0.859064483981573 0.303160051858994 no 1026 0.19515247025109 233 5537 A vasodilator.
SGTC_1171 0368-0077 21.4 µM 0.857277034945322 0.303640098297263 no 1027 0.195645898604835 222 3239779
SGTC_2316 5844804 197.44 µM 0.855738514283336 0.304053562789739 no 1028 0.19607121582086 224 776813
SGTC_1930 st074634 34.3 µM 0.855420122741543 0.304139159170104 no 1029 0.196159303737583 218 684253 YOR116C RPO31
SGTC_1245 0418-0076 17.2 µM 0.853352098404301 0.304695387970124 no 1030 0.196732038438733 218 6790114
SGTC_1688 st021091 57.6 µM 0.851941299193174 0.305075104719373 no 1031 0.197123336622185 228 3656366
SGTC_487 nimodipine 119 µM 0.850897879475742 0.305356076329955 no 1032 0.197413041454042 204 4497 L-type voltage-gated calcium channels inhibitor
SGTC_1257 0669-0121 16 µM 0.850631371603984 0.305427859852253 no 1033 0.197487078458071 228 4307855
SGTC_1976 st070609 63.5 µM 0.849464131175936 0.305742342541021 no 1034 0.197811540480316 213 682556
SGTC_666 0272-0154 136 µM 0.848055554914759 0.306122037743944 no 1035 0.198203516058575 224 6870312
SGTC_1038 k292-0204 154 µM 0.847905827839664 0.306162410368002 no 1036 0.198245209339106 218 4454212
SGTC_2138 5575593 77.673 µM 0.847858717909605 0.306175113644279 no 1037 0.198258328752878 221 762213
SGTC_3307 9126885 69.2785 µM 0.846432325307236 0.306559853239103 no 1038 0.198655805945653 197 24824909
SGTC_319 1348-1596 45.5 µM 0.846157021968124 0.306634135130068 no 1039 0.198732576999775 223 5380505
SGTC_1237 0330-0133 46.1 µM 0.844147239285743 0.307176651874042 no 1040 0.199293566525006 241 X1237 YHR072W ERG7
SGTC_1397 3532-0190 20.1 µM 0.843486621422553 0.307355070030731 no 1041 0.199478172466815 189 5322280
SGTC_1007 4101-0031 70 µM 0.84126565890699 0.30795523665653 no 1042 0.20009956226094 242 1146276
SGTC_365 0121-0052 13.6 µM 0.8381225008963 0.308805484805907 no 1043 0.200980953472064 197 3101739
SGTC_2469 5655019 90.81 µM 0.835485973042255 0.309519477041659 no 1044 0.201722070717074 226 2788239
SGTC_2691 st077356 60.2 µM 0.835332685228151 0.309561010732001 no 1045 0.201765209584411 228 2839272
SGTC_3308 9128332 17.569 µM 0.832368015982053 0.310364772674563 no 1046 0.202600624832276 214 17332805 YDL196W YDL196W
SGTC_1776 st049249 45.9 µM 0.831719875474294 0.310540613219726 no 1047 0.202783539619975 237 1822314
SGTC_290 2043-6722 48.1 µM 0.827327385261734 0.311733435425516 no 1048 0.204025762974932 224 773758 YLR208W SEC13
SGTC_3023 9089636 49.47 µM 0.827170604739719 0.311776047287423 no 1049 0.204070185110542 236 17249241
SGTC_2990 9074105 71.4286 µM 0.826755418675677 0.311888904161214 no 1050 0.204187851606796 236 6502001
SGTC_2390 9097792 176.6 µM 0.826368456566044 0.311994105036105 no 1051 0.204297555617445 219 4497149
SGTC_1097 itavastatin 7.23 µM 0.825770912478317 0.312156585591019 no 1052 0.204467028676117 237 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_484 loperamide 105 µM 0.824589760969732 0.312477864620475 no 1053 0.204802268192472 191 3955 An opioid-receptor agonist.
SGTC_279 1273-0055 2.93 µM 0.822777680743966 0.312971036491164 no 1054 0.205317215586088 251 2847562
SGTC_851 0394-0702 453 µM 0.822179049528598 0.31313403230628 no 1055 0.205487500308323 248 762646
SGTC_154 3389-1638 511.116 µM 0.819977030124004 0.313733914072991 no 1056 0.206114600897281 230 5238686
SGTC_3199 9111318 49.47 µM 0.819872981741518 0.313762271499041 no 1057 0.206144260293097 212 8548020
SGTC_1531 st059297 52.4 µM 0.816575931435216 0.31466142121062 no 1058 0.207085407145713 241 7566702
SGTC_1316 1272-0050 65.9 µM 0.81513507570445 0.315054707609639 no 1059 0.20749749798554 246 7340392
SGTC_99 0109-0120 622.8 µM 0.814827859802733 0.315138590364516 no 1060 0.20758542568084 245 759414
SGTC_1822 st052468 42 µM 0.814704316897309 0.315172325418449 no 1061 0.207620790873749 237 2873678
SGTC_2005 4024620 188 µM 0.813798119560493 0.315419821909459 no 1062 0.207880306268485 233 236743
SGTC_1168 k815-0004 80.5 µM 0.813270378142962 0.31556399441926 no 1063 0.208031528260055 242 642433
SGTC_616 4092-0450 108 µM 0.812236671810224 0.31584647170905 no 1064 0.208327920380638 259 787165
SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.811823378670182 0.315959440984886 no 1065 0.208446492598312 224 23665772 A membrane-active detergent.
SGTC_2452 5863136 48.41 µM 0.80986373812995 0.316495321677076 no 1066 0.209009247455802 241 2184096
SGTC_3180 9109287 49.47 µM 0.809766118895446 0.316522026591361 no 1067 0.209037304392704 240 18891271
SGTC_1311 1190-0148 100 µM 0.809619613985182 0.316562106564513 no 1068 0.209079415820274 241 1961333
SGTC_826 1683-5028 118 µM 0.809437203459746 0.316612012400598 no 1069 0.209131854953258 226 722377
SGTC_2010 4012422 159 µM 0.809296675861177 0.316650461731266 no 1070 0.209172258919141 235 952393
SGTC_2768 sulfasalazine 50.2 µM 0.807898127019033 0.317033222356499 no 1071 0.20957461480954 244 5384001 An antioxidant and salicylic acid derivative.
SGTC_3265 9137266 49.47 µM 0.806553560156383 0.317401393658042 no 1072 0.209961869218385 182 17224265
SGTC_129 0088-0017 176.636 µM 0.805989527186522 0.31755589183709 no 1073 0.210124443866301 227 182446
SGTC_2595 hexamethylquercetagetin 100 µM 0.805057516255965 0.31781125504968 no 1074 0.21039324502647 252 386331
SGTC_2073 5212005 126 µM 0.804600957196405 0.317936380057504 no 1075 0.210524994801515 244 691789
SGTC_2438 5259590 200 µM 0.802761320598329 0.31844076312453 no 1076 0.21105635124289 236 1201127
SGTC_407 eburnamonine 100 µM 0.801500418165142 0.318786666076574 no 1077 0.211421001041726 221 3195
SGTC_3239 9133757 49.47 µM 0.801021598117109 0.318918062014086 no 1078 0.211559571193169 262 17036923
SGTC_1123 mangostin 811.285 nM 0.800042139200184 0.319186912213355 no 1079 0.211843191418828 184 5281650 An antioxidant.
SGTC_169 k015-0017 16.025 µM 0.799062866603744 0.319455806368896 no 1080 0.212126979962831 277 1840002
SGTC_1886 st057356 49.9 µM 0.793942074848428 0.32086344609857 no 1081 0.213614576925389 216 24207747
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.793587067806868 0.320961128787305 no 1082 0.213717931752571 250 364106
SGTC_802 4112-3352 742 µM 0.792104376324085 0.321369235704358 no 1083 0.214149909271722 220 704594
SGTC_2756 carbadox 75.1 µM 0.791123850936741 0.321639241283266 no 1084 0.214435861149439 245 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.790582590016943 0.321788327744436 no 1085 0.214593804828575 262 229346 A bile salt which induces apoptosis.
SGTC_1086 cerivastatin 2.18 µM 0.790328097643967 0.321858435773942 no 1086 0.214668090828478 224 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_2498 4'-Methoxychalcone 54.63 µM 0.788904037678084 0.322250855422827 no 1087 0.215084047820264 228 641818 YHR062C RPP1
SGTC_1714 st033236 13.627 µM 0.788179692449536 0.32245053496029 no 1088 0.21529580292398 265 2916566
SGTC_55 0767-0285 6.563 µM 0.788152601213989 0.322458004168806 no 1089 0.215303725122778 267 3116166
SGTC_1856 st057054 55.7 µM 0.785101922511527 0.323299551526123 no 1090 0.216196906316375 252 1266018
SGTC_512 prima-1 270 µM 0.784494310416185 0.323467273039409 no 1091 0.216375059559502 220 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_1024 4507-0395 26 µM 0.783674555507358 0.323693609998842 no 1092 0.216615548153185 235 4201836
SGTC_2202 7226349 200 µM 0.781796237231588 0.324212465547566 no 1093 0.217167166375536 214 844334
SGTC_1691 st019933 84.6 µM 0.781502741393091 0.324293569985961 no 1094 0.217253432497832 260 6176082
SGTC_2662 daunorubicin 22.37 µM 0.781493668524213 0.324296077309181 no 1095 0.217256099567222 236 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_145 3737-0113 38.366 µM 0.781220020233671 0.324371704840795 no 1096 0.217336550372024 254 6849351
SGTC_2721 ifenprodil 61.44 µM 0.78094512465636 0.324447684376796 no 1097 0.217417385189314 248 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_3150 9097574 49.47 µM 0.779151062925626 0.324943731962085 no 1098 0.217945366745458 220 17217476
SGTC_2103 5378138 10 µM 0.778705969803996 0.325066845717761 no 1099 0.218076469338424 242 244142
SGTC_2341 7987486 176.74 µM 0.778452729376479 0.325136901114974 no 1100 0.218151081827554 227 1258686
SGTC_955 1216-0110 33 µM 0.776723759107176 0.325615361454951 no 1101 0.21866088309035 236 3619719
SGTC_1887 st057648 70.8 µM 0.775598582108909 0.325926887706216 no 1102 0.218993018915948 262 688672
SGTC_3119 9125183 49.47 µM 0.774731099342132 0.32616714950133 no 1103 0.219249285138347 206 22695334
SGTC_874 0599-0792 117 µM 0.77462723235199 0.326195921793927 no 1104 0.219279980412343 243 765305
SGTC_580 1123-0028 41 µM 0.772481231314061 0.326790618846232 no 1105 0.219914729460981 262 1677248 YPR107C YTH1
SGTC_3094 9117742 49.47 µM 0.769064910433803 0.327738253245235 no 1106 0.220927388832949 272 17149698
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.767976443417732 0.328040410672203 no 1107 0.221250590023148 252 551469
SGTC_1137 ixabepilone 100 µM 0.767838845234662 0.328078615818322 no 1108 0.221291466637053 243 154225 A novel microtubule stabilizer.
SGTC_625 k213-0058 121 µM 0.767203267683763 0.328255111931626 no 1109 0.22148033519043 260 3655420
SGTC_1500 4488-1866 171 µM 0.764004526533037 0.329143964785241 no 1110 0.222432272563194 268 2900003
SGTC_3230 9131665 49.47 µM 0.762606308694859 0.329532799687393 no 1111 0.222849110532916 242 15943720
SGTC_2357 9067248 200 µM 0.761874497887311 0.329736384843788 no 1112 0.223067455943735 256 9150235
SGTC_3 0833-0587 95.581 µM 0.761845931734443 0.329744332791162 no 1113 0.223075981502149 241 5382644
SGTC_2056 5235370 200 µM 0.76159320546997 0.329814652050256 no 1114 0.223151415649827 244 5511916
SGTC_6 0844-0013 19.835 µM 0.755333658027298 0.33155824014535 no 1115 0.225024404131413 274 1584900
SGTC_2610 ononetin 44.17 µM 0.754936740596879 0.331668924596752 no 1116 0.225143469797239 250 259632
SGTC_2953 9074162 66.49 µM 0.754823627870828 0.331700469919265 no 1117 0.225177407423478 234 16451992
SGTC_109 0132-0036 33.701 µM 0.754093693089644 0.33190406569866 no 1118 0.225396482111167 228 67274 A color developer.
SGTC_3185 9108267 49.47 µM 0.753737805663443 0.33200334898303 no 1119 0.225503338037925 256 4910486
SGTC_2427 5545055 42.75 µM 0.753045382553894 0.332196550718925 no 1120 0.225711321633648 254 5372858
SGTC_2753 fluvastatin 17.09 µM 0.752386301007349 0.332380490843543 no 1121 0.225909391169344 265 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_1491 4138-0063 26.5 µM 0.751670796662976 0.332580223465568 no 1122 0.226124528303735 241 23883227
SGTC_714 4296-0578 26.1 µM 0.748795108694296 0.333383449081932 no 1123 0.226990354154811 256 1589775
SGTC_533 1222-0222 6.71 µM 0.748350841535119 0.333507608278324 no 1124 0.227124282752515 253 3982874
SGTC_1357 1503-1303 39.5 µM 0.747067930556173 0.333866245331106 no 1125 0.227511278517856 238 292895
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.746846990320422 0.333928024383561 no 1126 0.22757796358057 246 6708514
SGTC_1333 1482-0047 286 µM 0.74642224885922 0.334046802741471 no 1127 0.227706191652857 248 3811116
SGTC_1015 4130-4525 82 µM 0.745790193933779 0.334223586795194 no 1128 0.227897082256913 256 1363237
SGTC_480 am 92016 50 µM 0.742497960620931 0.335145009530395 no 1129 0.228892843480361 293 2129 K+ channel blocker.
SGTC_2317 5986382 200 µM 0.735986247048766 0.336970413061614 no 1130 0.230869533749084 286 877883
SGTC_171 k064-0041 9.68 µM 0.734938373182561 0.337264519875487 no 1131 0.231188513473823 249 53325
SGTC_3003 9075612 71.4286 µM 0.734924900409065 0.33726830192761 no 1132 0.231192616275525 271 6501993
SGTC_757 1066-0008 322 µM 0.734026260218496 0.337520603656081 no 1133 0.231466366741592 244 6842497
SGTC_2132 5317594 122.667 µM 0.733343533209954 0.337712334561474 no 1134 0.23167446487819 277 794577
SGTC_3215 9129942 49.47 µM 0.733286945207054 0.337728228117803 no 1135 0.231691717823069 273 17682944
SGTC_1449 4112-4002 201 µM 0.731648125474536 0.338188639708829 no 1136 0.232191683103163 256 2059539
SGTC_2146 5545642 200 µM 0.730424662185441 0.338532518535925 no 1137 0.232565324016268 247 825326
SGTC_2809 7964133 12.99 µM 0.728786093066229 0.338993282097289 no 1138 0.233066259873113 267 1253665
SGTC_298 1391-0729 10 µM 0.728169114476771 0.339166838179372 no 1139 0.23325503489998 255 3237558
SGTC_1735 st034310 56.75 µM 0.727286322737381 0.339415226854396 no 1140 0.233525287466244 246 871153
SGTC_2253 7938677 135.83 µM 0.727244873658104 0.339426890983388 no 1141 0.233537980705505 228 2301972
SGTC_2244 6635614 200 µM 0.72503471668813 0.340049070797318 no 1142 0.234215366309727 253 836499
SGTC_1864 st057645 30.4 µM 0.721852396267094 0.340945688986612 no 1143 0.235192615697114 270 688666
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.720192196194986 0.341413807273482 no 1144 0.235703334032403 273 23847180
SGTC_3066 9117245 49.47 µM 0.718534414655283 0.341881487198009 no 1145 0.236213918045673 258 17176980
SGTC_2085 5307070 144.047 µM 0.716092948233621 0.342570695824473 no 1146 0.236966978882909 286 2840351
SGTC_3171 9103192 49.47 µM 0.715939273373484 0.342614094713744 no 1147 0.237014423401728 273 13018434
SGTC_527 4476-4215 268 µM 0.710075238824264 0.344271687920322 no 1148 0.238828740141817 247 4418754
SGTC_2060 5238662 140 µM 0.709776754981114 0.344356141077979 no 1149 0.238921292989621 275 790130
SGTC_571 k831-0106 44.2 µM 0.709333138256108 0.344481672538887 no 1150 0.239058884373895 280 4783639
SGTC_2973 9094665 17.96 µM 0.708756164584493 0.344644966014841 no 1151 0.239237902298221 280 25237061 YIL048W NEO1
SGTC_2714 st079313 56.9 µM 0.69963279900789 0.347230866093146 no 1152 0.242078326912018 272 2939799
SGTC_2037 5169046 200 µM 0.699484618006994 0.347272925231749 no 1153 0.242124611303099 258 5718022
SGTC_196 k015-0023 18.111 µM 0.698844344575196 0.347454679653403 no 1154 0.242324656093686 256 5211998
SGTC_947 3447-0010 211 µM 0.698284870678903 0.347613526230496 no 1155 0.242499529457365 280 748350
SGTC_3235 9132602 49.47 µM 0.698229114875322 0.347629357959531 no 1156 0.242516960654816 271 4912240
SGTC_803 4488-1585 147 µM 0.69759503699981 0.347809421567582 no 1157 0.242715243119673 252 747204
SGTC_2003 4023581 200 µM 0.697450271801022 0.347850536386923 no 1158 0.242760524940733 268 16641307
SGTC_1610 st001799 48.1 µM 0.696691724616443 0.348066000901121 no 1159 0.242997869392932 274 621897
SGTC_857 0438-0306 1.35 µM 0.693375364061855 0.349008584867791 no 1160 0.244037009321426 263 4686136
SGTC_1400 3771-8998 51.5 µM 0.692745353662745 0.349187753503876 no 1161 0.244234685741825 254 670767
SGTC_2095 5432005 200 µM 0.692245967512382 0.349329797802342 no 1162 0.244391437906058 287 783734
SGTC_3100 9120536 49.47 µM 0.690534603530814 0.349816734397503 no 1163 0.244929028407833 270 16421196
SGTC_2162 5663267 200 µM 0.689330012176004 0.350159626572973 no 1164 0.245307807742153 279 6456493
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.688970746881284 0.350261916672545 no 1165 0.245420838326412 287 4620898
SGTC_3038 9091290 49.47 µM 0.687118565231958 0.35078944248823 no 1166 0.246004007988934 268 25236843
SGTC_2115 tiliquinol 12.7705 µM 0.681736285980831 0.352324016853013 no 1167 0.24770285928047 282 71208 A bioactive hydroxyquinoline.
SGTC_856 0433-0016 11.3 µM 0.681308025250766 0.352446224591781 no 1168 0.247838303166717 273 3911780
SGTC_2213 7173844 200 µM 0.680444123831319 0.352692792350221 no 1169 0.248111645232784 277 892728
SGTC_552 k242-0005 476 µM 0.679474568598413 0.352969588676139 no 1170 0.248418608022176 303 4088318
SGTC_3206 9114350 49.47 µM 0.679355729776186 0.353003521083841 no 1171 0.248456246509804 262 17087243
SGTC_1429 4049-0205 9.46 µM 0.678977788409455 0.353111443593142 no 1172 0.248575967839469 264 22774478
SGTC_1470 k295-0292 231 µM 0.677990434177921 0.353393441863258 no 1173 0.248888879204767 285 5045612
SGTC_1609 st001574 46.4 µM 0.676915189777488 0.353700634015953 no 1174 0.249229882980061 291 3960012
SGTC_1663 st014140 55.4 µM 0.676529676009736 0.35381079666273 no 1175 0.249352205571145 267 4207120
SGTC_695 3505-6186 243 µM 0.675903785417008 0.353989674356219 no 1176 0.249550867098355 285 1819379
SGTC_59 0330-0160 1.33 µM 0.673201630471501 0.354762311812452 no 1177 0.250409512029149 294 4293482
SGTC_3213 9129884 49.47 µM 0.671590515758742 0.355223268681062 no 1178 0.250922208889258 272 17190742
SGTC_2952 9073731 13.78 µM 0.671030577250546 0.355383522639691 no 1179 0.251100525290177 284 16457353
SGTC_913 3487-1245 167 µM 0.669951357102801 0.355692466719523 no 1180 0.251444399645816 267 4016153
SGTC_590 k048-0076 22.4 µM 0.669623170989335 0.355786434069321 no 1181 0.251549019656634 295 6832814
SGTC_8 0354-0001 70 µM 0.669563746249422 0.35580344969756 no 1182 0.25156796568649 270 4993152
SGTC_2750 bromebric acid 70.15 µM 0.668104416781379 0.356221402906569 no 1183 0.252033471341177 278 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_3323 9138564 53.9225 µM 0.666464955598647 0.356691152085476 no 1184 0.252556978077549 281 43912313 YNL103W MET4
SGTC_1102 cgs 12066b 26.1 µM 0.66254764791236 0.357814444106334 no 1185 0.253810154417636 278 6438352 A 5-HT1B full agonist.
SGTC_2803 7707263 71.43 µM 0.662499412520356 0.357828283355377 no 1186 0.253825605603854 273 2199229
SGTC_1578 josamycin 24.2 µM 0.661128600803348 0.358221661933595 no 1187 0.254264922437993 276 5282165 A P450 substrate.
SGTC_1196 1588-0294 184 µM 0.660915669611484 0.358282779810054 no 1188 0.254333198239368 299 6144269
SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.660050167530981 0.358531243194703 no 1189 0.254610817993013 301 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_664 1222-0054 14.9 µM 0.65816729728898 0.359071973570046 no 1190 0.255215318094968 277 6813991
SGTC_624 k048-0052 28 µM 0.657061946690173 0.359389544334906 no 1191 0.255570542881289 276 6835531
SGTC_347 4534-1311 26.2 µM 0.653944481468993 0.360285724833386 no 1192 0.256573787379847 288 2862016
SGTC_2462 5162487 171.77 µM 0.652428249333926 0.360721875432529 no 1193 0.257062472754008 290 2259986
SGTC_1790 st045711 43.5 µM 0.65045244140031 0.361290496838804 no 1194 0.257700006228955 244 585119
SGTC_1652 st011932 78 µM 0.648294188128141 0.361911974865941 no 1195 0.258397346166281 284 1551076
SGTC_1192 1488-0095 21.4 µM 0.647972227435628 0.362004716056121 no 1196 0.258501456642007 299 915875
SGTC_2311 7694451 200 µM 0.647894606264615 0.362027076146396 no 1197 0.258526559779112 304 2163142
SGTC_3070 9117005 49.47 µM 0.643294810480364 0.363352963459122 no 1198 0.260016411496821 293 8779016
SGTC_2540 epiandrosterone 100 µM 0.641680797753171 0.363818590527494 no 1199 0.260540229786173 304 441302 A steroid.
SGTC_142 0335-0849 62.6745 µM 0.641385232639533 0.363903880018911 no 1200 0.260636212520368 277 3889043 YPR107C YTH1
SGTC_2109 5483026 200 µM 0.640194680103253 0.364247499026247 no 1201 0.261023020480353 318 759335
SGTC_380 3970-0968 6 µM 0.639614061869575 0.364415117519304 no 1202 0.261211769107079 276 2891601
SGTC_2937 9044753 11.33 µM 0.637817386683866 0.364933963251976 no 1203 0.261796280116147 282 6465530 YGL099W LSG1
SGTC_3009 9080819 71.4286 µM 0.637815901613139 0.364934392214714 no 1204 0.261796763530475 287 17027216
SGTC_970 1315-0089 19.5 µM 0.637370358169584 0.365063095087113 no 1205 0.261941815736736 279 6811083 YLR033W RSC58
SGTC_2334 9017922 200 µM 0.636887829141937 0.365202499028194 no 1206 0.262098955528083 305 3163164
SGTC_2870 9038528 12.99 µM 0.635241393110455 0.365678292843858 no 1207 0.262635495226561 295 6463316
SGTC_3016 9080866 49.47 µM 0.631134313713273 0.366866073049754 no 1208 0.26397635332883 291 17066299
SGTC_358 0075-0058 9.45 µM 0.630115547115832 0.367160901452142 no 1209 0.264309494219533 341 1069125
SGTC_1929 genistein trimethyl ether 50.5 µM 0.629877836136394 0.36722970567069 no 1210 0.264387257481876 284 136420
SGTC_2856 9022925 19.48 µM 0.629282942507844 0.367401913249559 no 1211 0.264581918239417 275 4944862
SGTC_865 0488-0499 301 µM 0.628873876268075 0.367520343689707 no 1212 0.264715814956987 273 9634651
SGTC_2252 omeprazole 400 µM 0.625619443306018 0.368462995934847 no 1213 0.265782291290932 279 4594 A proton pump inhibitor.
SGTC_330 1488-0319 80.1 µM 0.624707040546238 0.368727417434709 no 1214 0.26608167570736 303 6846614
SGTC_1389 3405-0187 19 µM 0.624702536652358 0.368728722852876 no 1215 0.2660831539822 281 799890
SGTC_3228 9131799 49.47 µM 0.624104565799987 0.36890205343965 no 1216 0.266279457804186 303 17015818
SGTC_2816 7982706 58.44 µM 0.62299990981167 0.369222324225751 no 1217 0.266642290553274 301 2981853
SGTC_2121 5257820 149.641 µM 0.616702935591269 0.371049721783631 no 1218 0.268715342292689 279 791256
SGTC_1508 1080-0625 72.9 µM 0.613274810888064 0.372045798901051 no 1219 0.269847322939441 298 767111
SGTC_2295 7971645 200 µM 0.612841847597059 0.372171661950039 no 1220 0.269990458785323 297 2978226 YKL099C UTP11
SGTC_688 0527-0193 473 µM 0.612342682202264 0.372316786994853 no 1221 0.270155527908105 326 4007154
SGTC_872 0588-0139 234 µM 0.61003312354838 0.372988493193126 no 1222 0.27091993288836 286 2047100
SGTC_1390 3413-2614 145 µM 0.60859897979579 0.373405790488201 no 1223 0.271395140435293 329 3421432
SGTC_668 1682-0499 62.6 µM 0.608145892144264 0.373537657712823 no 1224 0.271545358581998 303 682214
SGTC_703 3875-0075 71.8 µM 0.607745532943133 0.373654191104638 no 1225 0.271678129419374 326 2850814
SGTC_975 1335-0046 28.5 µM 0.607612884082053 0.373692804035125 no 1226 0.271722126793393 310 16486740
SGTC_1454 4239-0054 42.6 µM 0.605090116856858 0.374427400583877 no 1227 0.272559560338408 314 1340767
SGTC_852 0418-0143 439 µM 0.600470391920953 0.375773784141188 no 1228 0.274096393712347 290 5369229
SGTC_2215 7188065 200 µM 0.599723564200169 0.375991583961089 no 1229 0.274345240598129 305 940217
SGTC_2518 prenyletin 46.28 µM 0.599127468517992 0.376165453657223 no 1230 0.274543942789338 274 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_2461 5755302 26.15 µM 0.598688987375688 0.376293366258073 no 1231 0.274690151150385 337 2788904
SGTC_1111 tnp00062 510.699 nM 0.598433809172325 0.376367812448768 no 1232 0.274775256145351 290 676306
SGTC_40 0327-0103 19.753 µM 0.598418471712206 0.376372287176095 no 1233 0.274780371786579 294 409036
SGTC_3354 9151612 71.43 µM 0.594279867167956 0.377580336659972 no 1234 0.276162470990169 293 27261949
SGTC_1232 0279-0259 161 µM 0.594247969058005 0.377589652317071 no 1235 0.276173136694845 311 1560000
SGTC_882 0843-0131 351 µM 0.593014697054037 0.377949876767897 no 1236 0.276585658237148 299 5425421
SGTC_2748 diazoxide 86.69 µM 0.592789913777592 0.378015544802005 no 1237 0.276660879325042 269 3019 A potassium channel activatior.
SGTC_1955 wogonin 32.4 µM 0.592333048284822 0.378149024037724 no 1238 0.276813794893324 276 5281703 A flavanone.
SGTC_620 0109-0052 432 µM 0.591898651602172 0.37827595220654 no 1239 0.276959228402969 311 493037
SGTC_2992 9074591 71.4286 µM 0.590459321982066 0.378696609706512 no 1240 0.27744137482883 313 17741321
SGTC_1816 st051957 91.6 µM 0.590034259800915 0.378820865609383 no 1241 0.277583840532056 304 674121
SGTC_1002 4049-0206 172 µM 0.589416716162273 0.379001410788757 no 1242 0.277790882831331 311 4662749
SGTC_412 gemfibrozil 100 µM 0.589072042318046 0.379102191184142 no 1243 0.277906473540807 298 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.588121274684908 0.379380232052428 no 1244 0.27822544707109 336 5393153
SGTC_1546 5-methoxyflavanone 78.7 µM 0.584249572679186 0.380513108995474 no 1245 0.279526206911677 289 147795
SGTC_1270 0831-1170 17.3 µM 0.584163778517734 0.380538224391655 no 1246 0.279555064232126 307 6764716
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.583607373828422 0.380701118604583 no 1247 0.279742248994514 312 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1570 verbenone 133 µM 0.582019937956659 0.381165975849599 no 1248 0.280276625604714 320 29025 A natural terpanoid with antifungal properties.
SGTC_90 0870-0863 4.608 µM 0.581443574794493 0.381334797804124 no 1249 0.280470768311638 340 1738164
SGTC_2383 9036125 200 µM 0.580447766280706 0.381626532272885 no 1250 0.280806350697341 303 79580
SGTC_2407 paclitaxel 400 µM 0.578832781412274 0.382099805061896 no 1251 0.281351004755431 360 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1302 1159-0335 255 µM 0.577476114106657 0.382497513887127 no 1252 0.281808934874375 309 649284
SGTC_1556 plumbagin 1.48 µM 0.576878634160487 0.382672705272887 no 1253 0.282010722405275 308 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_495 decylubiquinone 155 µM 0.57331211308882 0.383718968824606 no 1254 0.283216692617846 338 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_1602 st001878 87.6 µM 0.573215898150615 0.383747205925133 no 1255 0.283249260620246 334 595405 YLR310C CDC25
SGTC_3240 9133527 49.47 µM 0.572458748990694 0.383969435123756 no 1256 0.283505612344912 338 17617455
SGTC_152 4469-0003 551.229 µM 0.572299753458378 0.384016106405924 no 1257 0.283559458368885 315 697280
SGTC_327 1273-0057 3.96 µM 0.572132592370069 0.384065176405573 no 1258 0.283616075054458 311 3108138
SGTC_3005 9076496 71.4286 µM 0.571540157294268 0.38423910019419 no 1259 0.283816773663945 309 21368410
SGTC_2884 9058502 51.95 µM 0.571399108116182 0.384280512062962 no 1260 0.283864566765302 304 6471554
SGTC_384 k007-0144 5.16 µM 0.569920260656408 0.384714779339586 no 1261 0.284365891210974 320 6824886
SGTC_62 0180-0423 3.232 µM 0.569640524856083 0.384796940750366 no 1262 0.284460768295245 333 30102 YGL099W LSG1
SGTC_1583 clindamycin 39.6 µM 0.567388500920724 0.385458572571336 no 1263 0.285225130346342 334 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_2302 7771753 200 µM 0.567122670731702 0.385536694011068 no 1264 0.285315420619059 299 2203047
SGTC_2159 5658611 73.75 µM 0.566569866519411 0.38569916544863 no 1265 0.285503226335326 340 793844
SGTC_2367 9070478 135.38 µM 0.565723444375689 0.385947971261689 no 1266 0.285790897676431 303 572802
SGTC_572 0960-0087 17.7 µM 0.563517476511547 0.3865966358402 no 1267 0.286541281491253 331 6796365
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.561575243972552 0.387168011560809 no 1268 0.287202725633767 318 4330530
SGTC_92 0063-0024 660.874 µM 0.560686653577914 0.387429503159093 no 1269 0.287505583574868 315 3594437
SGTC_639 0833-0042 114 µM 0.558720933633902 0.388008150395118 no 1270 0.288176095192147 331 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_2917 7979103 53.79 µM 0.556634486633176 0.388622608070075 no 1271 0.288888593135986 323 2980565
SGTC_2984 9022109 38.96 µM 0.556545441451827 0.38864883804836 no 1272 0.288919019490846 333 6459207
SGTC_1419 3993-2473 62.6 µM 0.554726668788154 0.389184703600176 no 1273 0.289540815979543 323 704026
SGTC_203 k066-0004 30.888 µM 0.55447477964713 0.389258934420001 no 1274 0.289626980591348 328 6795412
SGTC_3050 9093513 49.47 µM 0.552444689433049 0.389857341998827 no 1275 0.290321859793274 323 25236664
SGTC_2706 st078239 82.5 µM 0.552416650172653 0.389865608934106 no 1276 0.290331462810365 320 15434492
SGTC_1806 st050005 60.3 µM 0.55149649780195 0.390136929023377 no 1277 0.290646683403418 301 5194765
SGTC_3099 9120367 49.47 µM 0.549754841367961 0.390650627781029 no 1278 0.291243768102386 331 24824940
SGTC_1817 st052116 64.4 µM 0.547749581199538 0.391242312438646 no 1279 0.291931931252176 313 4361398
SGTC_1972 st070201 17.4 µM 0.547402491705701 0.391344752443975 no 1280 0.292051121907835 320 2829099
SGTC_3214 9129694 49.47 µM 0.546634474646535 0.39157145180603 no 1281 0.292314939726591 346 17158655
SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.545967720389045 0.391768290798766 no 1282 0.292544063088707 297 3256 An antibiotic and ribosome inhibitor.
SGTC_452 diindolylmethane 8 µM 0.545945575096343 0.391774829001189 no 1283 0.292551674526517 340 3071 Inhibits expression of several cancer promoting factors.
SGTC_3086 9117350 49.47 µM 0.545248560865425 0.391980631919888 no 1284 0.292791288503747 305 2679265
SGTC_1503 4585-0012 61.3 µM 0.544499853392144 0.392201731640847 no 1285 0.293048774632681 321 2922052
SGTC_2495 cafestol 54.53 µM 0.543968275319425 0.392358732326594 no 1286 0.293231652068418 336 16667697 An anti-infammatory.
SGTC_338 4055-0136 114 µM 0.540126690675 0.393493857237165 no 1287 0.294554832484744 313 2900563
SGTC_652 0437-0092 114 µM 0.53933150407747 0.393728935238179 no 1288 0.294829067237054 304 3091274
SGTC_1757 st041620 31.8375 µM 0.539017750062269 0.393821699810601 no 1289 0.29493730346264 326 5289815
SGTC_959 1222-0044 107 µM 0.538823408407488 0.393879161923913 no 1290 0.295004354996617 339 6083612
SGTC_1254 0550-0035 264 µM 0.538803725569125 0.393884981790662 no 1291 0.295011146338468 340 15121435
SGTC_2425 5628681 7.85 µM 0.537626413618485 0.394233135146211 no 1292 0.295417495505015 334 5714958
SGTC_2045 5106652 78.05 µM 0.535946037447588 0.39473020043787 no 1293 0.295997922839395 316 673349
SGTC_1802 st050112 57.9 µM 0.53475195738548 0.395083520675376 no 1294 0.296410694060446 326 4662563
SGTC_1065 prochlorperazine maleate 2.48 µM 0.534471926855684 0.395166392321379 no 1295 0.296507533576274 336 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_1472 k841-0093 193 µM 0.533652817046979 0.395408825163881 no 1296 0.296790879441394 336 X1472
SGTC_2399 5884133 200 µM 0.533545711199945 0.395440528395519 no 1297 0.296827938578958 322 722445
SGTC_38 0929-0051 58.268 µM 0.533128088921681 0.395564150810997 no 1298 0.296972458118563 344 1379719
SGTC_2967 9089538 49.85 µM 0.532645509170876 0.395707014692745 no 1299 0.297139496478007 328 728216
SGTC_3251 9135047 49.47 µM 0.52836651816331 0.396974386733296 no 1300 0.298622485764972 315 17682963
SGTC_1061 3448-9325 110 µM 0.527534830421031 0.397220846792711 no 1301 0.298911117773364 339 723482
SGTC_2210 7115885 190.385 µM 0.525338387432716 0.397871931768702 no 1302 0.299673988109465 345 2927039
SGTC_1753 st043925 64 µM 0.521171318729546 0.399107943999539 no 1303 0.30112371612085 326 670181
SGTC_25 0118-0223 35.662 µM 0.520068614013859 0.399435191885458 no 1304 0.301507876503452 348 5333628
SGTC_3127 9126946 49.47 µM 0.518428286567609 0.399922119885964 no 1305 0.302079741573245 350 27243249
SGTC_2608 thymoquinone 42.66 µM 0.5183076794575 0.399957928023341 no 1306 0.302121807876486 328 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_3115 9123671 49.47 µM 0.515679099290846 0.400738559463866 no 1307 0.303039277335622 334 3286988
SGTC_3088 9117578 49.47 µM 0.512146413169504 0.401788314957795 no 1308 0.304274271748511 333 678341
SGTC_2885 9057732 51.95 µM 0.511964222489177 0.401842473127447 no 1309 0.304338024667704 334 6471414
SGTC_1020 4335-0961 93.3 µM 0.511644784287823 0.401937434171109 no 1310 0.304449818162274 364 669075
SGTC_1134 3477-0009 42.5 µM 0.511462806824164 0.401991534140296 no 1311 0.30451351281894 380 3973534
SGTC_2094 5332512 191.667 µM 0.511215944235885 0.402064926770035 no 1312 0.304599927652475 338 755774
SGTC_1647 st011722 22.4 µM 0.511020546957523 0.402123021132006 no 1313 0.304668334665302 323 2854783
SGTC_2924 9010168 62.78 µM 0.507490854683206 0.403172819459525 no 1314 0.305905225810654 339 2993929
SGTC_1708 st033234 31.827 µM 0.506293106512373 0.403529211840647 no 1315 0.306325450789162 307 674664
SGTC_2031 5180455 200 µM 0.505439464771632 0.40378326358093 no 1316 0.306625103056402 337 29949
SGTC_125 0133-0007 11.75 µM 0.505430812709411 0.403785838723306 no 1317 0.306628140835919 333 26541
SGTC_2054 5233173 129 µM 0.501358494815548 0.40499835746198 no 1318 0.308059422349967 304 6889
SGTC_2379 9035213 200 µM 0.500902335148754 0.405134234495436 no 1319 0.308219929502974 342 646551
SGTC_724 3910-0327 137 µM 0.500176805395877 0.405350372795531 no 1320 0.308475294428161 365 2885483
SGTC_2960 9079389 5.97 µM 0.497776333897102 0.406065688548871 no 1321 0.309320849188298 324 16457355
SGTC_57 miconazole 162.5 nM 0.497152989480741 0.406251490158532 no 1322 0.309540584811518 328 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_540 1187-0821 17.3 µM 0.49709576111005 0.406268549400768 no 1323 0.309560761843178 347 847520
SGTC_140 0062-0056 502.533 µM 0.495749477729089 0.406669915150221 no 1324 0.310035587037823 316 3758964
SGTC_1903 st060211 78.3 µM 0.495101521908565 0.406863124375697 no 1325 0.310264229791192 321 688960
SGTC_2863 9028737 58.44 µM 0.494943923950157 0.406910120792082 no 1326 0.310319852132408 352 6460917
SGTC_2245 6637752 200 µM 0.494936891138132 0.406912218039347 no 1327 0.310322334381628 361 681890
SGTC_2358 9037157 4 µM 0.493149515125355 0.407445315897091 no 1328 0.310953473260468 331 2388925
SGTC_2915 7971052 15.16 µM 0.492071966932706 0.407766785367413 no 1329 0.311334234422175 323 5741558
SGTC_3329 9141233 27.5565 µM 0.490296197569768 0.408296693510019 no 1330 0.31196215865931 336 4909101 YNL103W MET4
SGTC_2994 9053520 71.4286 µM 0.488434856088578 0.408852317321968 no 1331 0.312620928870677 360 4647384
SGTC_1506 4226-2149 212 µM 0.48735331075256 0.409175250614069 no 1332 0.313003987200751 350 991114
SGTC_257 daunorubicin 18.5 µM 0.487275595366006 0.409198457645096 no 1333 0.313031519973775 365 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1854 st056233 32.9 µM 0.484694523955729 0.409969386299329 no 1334 0.31394652575422 348 5393174
SGTC_1938 st074717 56.4 µM 0.48461827512588 0.409992166029374 no 1335 0.313973573877492 333 17250979
SGTC_2000 st075254 36.4 µM 0.477564291832834 0.412100883989093 no 1336 0.316480175562015 329 17234175
SGTC_1343 1487-0095 224 µM 0.476974186158591 0.412277406186768 no 1337 0.31669025172001 384 4560101 YGL055W OLE1
SGTC_1710 st031758 61.5 µM 0.474761293840254 0.412939521029876 no 1338 0.317478562132021 354 5394341
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.474556014581587 0.413000954789589 no 1339 0.317551731900443 320 6708739 YPR165W RHO1
SGTC_215 1287-0124 461.5 µM 0.474389643660186 0.413050746045499 no 1340 0.317611038405359 358 5560863
SGTC_2701 st077767 14.721 µM 0.473904998254267 0.413195798011583 no 1341 0.317783827392056 348 5721188
SGTC_1518 st038567 90.8 µM 0.471404105629904 0.413944490694455 no 1342 0.318676092325037 363 77966
SGTC_2899 9053889 58.44 µM 0.471097582411384 0.414036276185958 no 1343 0.31878552574101 344 6470052
SGTC_1189 1431-2119 7.28 µM 0.470446870239977 0.414231141377862 no 1344 0.319017892183704 356 3107275
SGTC_2624 nerol 100 µM 0.469924523504009 0.414387580960064 no 1345 0.319204471376589 370 637566 A natural product oil.
SGTC_2801 7907800 81.82 µM 0.468591846158458 0.414786770970855 no 1346 0.319680703327134 361 6620925
SGTC_2194 5927483 104.545 µM 0.467578297382078 0.415090428192432 no 1347 0.320043093953199 302 760979
SGTC_2247 cerulenin 830 nM 0.466205712258515 0.415501732837008 no 1348 0.320534130483879 329 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_2938 9059746 27.26 µM 0.465074547074017 0.415840763947628 no 1349 0.320939036336345 357 6471769
SGTC_3018 9082602 49.47 µM 0.464489865357886 0.416016028438694 no 1350 0.321148409436825 353 17332089
SGTC_1549 4'-methoxyflavonol 74.6 µM 0.460942748137151 0.417079670960055 no 1351 0.322419840500179 347 97141
SGTC_1865 st057639 52.2 µM 0.459855294991188 0.417405877840987 no 1352 0.322810045201381 359 688818
SGTC_2728 chlorpromazine 9.18 µM 0.459405612633892 0.417540787159084 no 1353 0.322971459258016 391 2726 A thorazine and dopamine antagonist.
SGTC_1970 st070122 35.8 µM 0.459172082091348 0.417610852546787 no 1354 0.323055298502915 369 102928
SGTC_2761 levamisole 97.89 µM 0.457016673554687 0.418257655765639 no 1355 0.32382953056084 364 26879 An alkaline phosphatase inhibitor.
SGTC_246 cycloheximide 667 µM 0.456887178922833 0.418296522067461 no 1356 0.323876069918794 354 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_900 1112-0045 141 µM 0.451797446909925 0.419824773879976 no 1357 0.325707454570497 343 56211 YIL048W NEO1
SGTC_598 3937-0236 20.2 µM 0.448614387688019 0.420781141221399 no 1358 0.326854926499637 363 1379313
SGTC_58 0957-0393 9 µM 0.448456443837197 0.420828608531349 no 1359 0.326911906996654 340 6997992
SGTC_419 nsc-638432 893 µM 0.448248950365974 0.420890968877399 no 1360 0.32698676935984 337 368090
SGTC_2796 7949634 45.45 µM 0.448049919011876 0.420950787873501 no 1361 0.327058585186455 359 2971588
SGTC_2125 5246583 200 µM 0.447794931917728 0.421027427068418 no 1362 0.327150600696263 394 835267
SGTC_3074 9116018 49.47 µM 0.44582744556949 0.421618877300062 no 1363 0.327860947466896 379 17027303
SGTC_3179 9107801 49.47 µM 0.441709721742799 0.42285728590337 no 1364 0.329349636907676 324 4818259
SGTC_1248 0469-0687 58.6 µM 0.44139169873139 0.422952963453757 no 1365 0.329464725441514 357 4017482
SGTC_1 0258-0098 57.368 µM 0.440444871012221 0.423237844433555 no 1366 0.329807466120621 327 6790032 YDR047W HEM12
SGTC_1611 st001856 99.4 µM 0.440003478627826 0.423370664046688 no 1367 0.329967293929079 401 647478
SGTC_2235 salicylic acid 500 µM 0.438173503520209 0.423921415542812 no 1368 0.330630257236909 345 338 A COX inhibitor and kinase inhibitor.
SGTC_557 1315-0110 16.2 µM 0.438123562585208 0.423936447914606 no 1369 0.330648357299663 354 6833801
SGTC_1471 k673-0312 37 µM 0.437231671151572 0.424204928539432 no 1370 0.330971671628998 351 24099884
SGTC_870 0573-2213 57.6 µM 0.435947487196013 0.424591560342866 no 1371 0.331437415067993 337 3916321
SGTC_1138 3761-0006 1.03 µM 0.435466670646334 0.424736339423463 no 1372 0.331611863108199 353 12061087
SGTC_722 3534-0461 190 µM 0.434994192972709 0.424878617469314 no 1373 0.331783321254014 335 658262
SGTC_2619 obliquin 87.91 µM 0.433355698280353 0.425372096004687 no 1374 0.332378189926765 370 6708593 A bioactive alkalod. YER133W GLC7
SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.43121484848846 0.426017048939469 no 1375 0.333156079176042 355 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_2627 acetyl isogambogic acid 100 µM 0.430228046647084 0.426314399858993 no 1376 0.33351488099571 363 6857789 A caspase activator and apoptosis inducer.
SGTC_3233 9132340 49.47 µM 0.429251931190463 0.426608571888855 no 1377 0.333869947135192 394 17682950
SGTC_3317 9138495 8.753 µM 0.429205469387426 0.426622575107174 no 1378 0.333886851525389 359 17020139
SGTC_656 4090-1979 187 µM 0.429164488274136 0.426634926565915 no 1379 0.333901762133342 379 22330961
SGTC_1412 3909-8563 178 µM 0.428483762256076 0.426840103768984 no 1380 0.334149476488361 381 23767530
SGTC_3135 9127742 49.47 µM 0.425547586063733 0.42772532096103 no 1381 0.335218769934941 358 3643468
SGTC_2654 protoveratrine a 100 µM 0.425447275942501 0.427755569552604 no 1382 0.335255324425305 387 5702278 A heart drug and vasodilator.
SGTC_1096 rimcazole 32.2 µM 0.424676146955475 0.427988118237353 no 1383 0.335536387293669 383 18528119 A dopamine reuptake inhibitor.
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.424494468403915 0.428042910520915 no 1384 0.335602619314821 350 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_2196 6573537 42.6665 µM 0.423144743047695 0.428450016444325 no 1385 0.336094829724157 388 2903087
SGTC_2097 5376186 200 µM 0.422470145203201 0.428653518096 no 1386 0.336340943790112 352 742755
SGTC_2976 9009005 19.48 µM 0.422001346929555 0.428794948672438 no 1387 0.336512017155594 357 2993148
SGTC_2833 9001315 45.46 µM 0.420582422788691 0.429223075988674 no 1388 0.337030015573401 348 2989378
SGTC_1983 st071813 46.9 µM 0.420572120625457 0.429226184731615 no 1389 0.337033777656208 371 11838595
SGTC_1851 st056236 18.9 µM 0.419967894623301 0.429408521423121 no 1390 0.337254453823011 355 5393171
SGTC_728 3030-5151 22.5 µM 0.41965289136729 0.429503585623808 no 1391 0.337369521914802 367 3125388
SGTC_3183 9108214 49.47 µM 0.418430758700135 0.42987244923977 no 1392 0.337816100813429 359 4974831
SGTC_2166 5933061 31.504 µM 0.418394360023886 0.429883436014768 no 1393 0.337829404741549 364 2877375
SGTC_1620 st003704 16.5 µM 0.416671560847424 0.430403517073691 no 1394 0.338459329356438 365 2834414
SGTC_1121 fusaric acid 630.51 nM 0.415115876301205 0.430873253109092 no 1395 0.339028538847927 329 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_979 1426-2828 121 µM 0.414701909537372 0.430998266102199 no 1396 0.339180067155502 375 747872
SGTC_230 MPP+ 141.667 µM 0.413123836164124 0.431474888624723 no 1397 0.339757943232253 366 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_1396 3511-0007 98.6 µM 0.412614910439906 0.4316286198141 no 1398 0.339944387615065 389 X1396
SGTC_3013 9080133 71.4286 µM 0.411700998762353 0.431904711088251 no 1399 0.340279296423803 359 17050193
SGTC_2388 9080168 200 µM 0.410820025883363 0.43217088309176 no 1400 0.340602253904725 393 15943073
SGTC_2688 kanamycin b 96.69 µM 0.410549018464052 0.432252769889919 no 1401 0.340701626539721 357 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_2933 9026794 32.47 µM 0.40946099089871 0.432581554334426 no 1402 0.341100694263679 399 17586027
SGTC_2178 5812956 200 µM 0.408521770923337 0.432865409069861 no 1403 0.341445325228969 347 5403383
SGTC_2343 7990716 14.84 µM 0.408145814976636 0.432979041664559 no 1404 0.341583313017475 374 6456862
SGTC_2731 amoxapine 43.43 µM 0.407403100526902 0.433203543208572 no 1405 0.341855975061299 391 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_2324 6149169 200 µM 0.407098690528519 0.433295563962587 no 1406 0.341967752561415 403 2888231
SGTC_1960 st011366 51.8 µM 0.406789896701001 0.43338891360874 no 1407 0.342081153930442 365 3972846
SGTC_2303 7774051 200 µM 0.406052382275112 0.433611882285857 no 1408 0.342352056172426 393 2953184
SGTC_450 aminopyrene 156 nM 0.403989505952257 0.434235652313105 no 1409 0.343110218031402 398 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_1413 3910-0535 34.4 µM 0.403633423172257 0.434343340808257 no 1410 0.343241151961402 381 2876951
SGTC_2239 6685329 187.64 µM 0.403622410443972 0.434346671415283 no 1411 0.343245201712573 327 805680
SGTC_1395 3486-0190 4.35 µM 0.403378844839311 0.434420334762613 no 1412 0.343334773591223 384 6748079
SGTC_3196 9111891 49.47 µM 0.403232923927888 0.434464467794005 no 1413 0.343388440598346 385 18891510
SGTC_1298 1079-1278 263 µM 0.40301814221544 0.434529428907183 no 1414 0.34346743907654 376 2840950
SGTC_2070 5230947 200 µM 0.402713558706366 0.434621553764843 no 1415 0.343579479117526 411 2835538
SGTC_1100 amiodarone 5.07 µM 0.402084770921962 0.434811749234781 no 1416 0.343810820096857 353 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.401674565440188 0.434935836153823 no 1417 0.34396177272041 375 2724278 An inhibitor of dopamine biosynthesis.
SGTC_3260 9137109 49.47 µM 0.400161855229568 0.435393485409376 no 1418 0.344518653871316 379 17478346
SGTC_1251 0490-5699 265 µM 0.400142556719181 0.435399324463395 no 1419 0.344525760503679 384 3883818
SGTC_1646 st011709 75.6 µM 0.399917382254337 0.435467455418577 no 1420 0.344608684541173 364 5757843
SGTC_1893 st059353 36.1 µM 0.399615272583707 0.435558867639506 no 1421 0.344719952908231 400 3112488
SGTC_2693 st077581 40.7 µM 0.399530665881601 0.435584468518327 no 1422 0.344751116350082 396 25238761
SGTC_2708 st078559 56 µM 0.395627839369006 0.436765704375825 no 1423 0.346189798238087 361 17250902
SGTC_886 0866-0150 153 µM 0.394864002407518 0.436996954848429 no 1424 0.346471628827172 391 271463
SGTC_2906 7926292 26.41 µM 0.394477937310098 0.437113843662065 no 1425 0.346614106438765 389 2966319
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 0.39427558695214 0.43717511141258 no 1426 0.346688792657758 355 5379071
SGTC_2305 7443522 69.23 µM 0.393849649579791 0.437304081881838 no 1427 0.34684602287907 392 5415886
SGTC_489 paxilline 115 µM 0.393587916272989 0.437383335963778 no 1428 0.346942652013726 370 105008 A toxic potassium channel blocker.
SGTC_690 glyoxal 20.3 µM 0.392533643863161 0.437702600042338 no 1429 0.347331978850526 373 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_3044 9093193 49.47 µM 0.390022020333837 0.438463355094179 no 1430 0.348260131971945 395 25236277
SGTC_790 1575-0012 79.1 µM 0.389819702464757 0.438524645846246 no 1431 0.348334936797536 411 378741 YLR208W SEC13
SGTC_2947 9072639 7.68 µM 0.389778237481234 0.438537207548671 no 1432 0.34835026875156 356 16488146
SGTC_3067 9117431 49.47 µM 0.389275080355669 0.438689642543044 no 1433 0.348536334192906 392 17150885
SGTC_1515 3460-0031 42.1 µM 0.387131317023145 0.439339212394397 no 1434 0.349329497052924 386 2876596
SGTC_1557 sumaresinolic acid 42.3 µM 0.386021142565483 0.439675664526436 no 1435 0.349740505301333 366 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_2979 9012552 45.46 µM 0.384893332476086 0.440017505973456 no 1436 0.350158222998241 402 17100905
SGTC_910 3454-3003 490 µM 0.384823033915518 0.440038815088069 no 1437 0.35018426615088 402 820824
SGTC_2112 5488546 200 µM 0.384686162920533 0.440080304340782 no 1438 0.35023497407818 391 600757
SGTC_2234 tolnaftate 200 µM 0.38302245744238 0.440584670361578 no 1439 0.350851556441636 407 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_1737 st035557 69.7 µM 0.382856022715103 0.440635131738261 no 1440 0.350913260113407 369 5716916
SGTC_1838 st055369 84.5 µM 0.382794309876139 0.440653842710711 no 1441 0.350936140404954 337 676036
SGTC_2515 chrysin 20.77 µM 0.382424447452971 0.440765985613204 no 1442 0.351073279760256 360 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_86 0417-1630 471.922 µM 0.381747784376133 0.44097116327403 no 1443 0.351324226325428 372 3634867
SGTC_2419 paclitaxel 166.5 µM 0.381334244684109 0.441096564512562 no 1444 0.351477623149947 395 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_3218 9131285 49.47 µM 0.381173177846194 0.441145407809889 no 1445 0.35153737521136 397 17156417
SGTC_582 0987-0078 156 µM 0.380805704126557 0.441256847060457 no 1446 0.351673713169532 384 1625765
SGTC_2550 chrysin dimethyl ether 71.87 µM 0.379981871579529 0.441506697547395 no 1447 0.351979436032597 371 88881 An O-methylated flavonoid and antioxidant.
SGTC_1337 1486-1011 40.3 µM 0.379329665858247 0.441704513866371 no 1448 0.352221536364739 371 X1337
SGTC_146 3448-8650 53.125 µM 0.379269014151211 0.441722910484951 no 1449 0.352244053469965 410 2891488 YIL048W NEO1
SGTC_3305 9127027 53.8275 µM 0.378880382595903 0.441840791542065 no 1450 0.352388346243363 375 41905295
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.377389042727754 0.442293197589092 no 1451 0.352942254289988 415 688667
SGTC_3102 9121669 49.47 µM 0.377287009061852 0.44232415281343 no 1452 0.352980162673566 389 41905072
SGTC_1034 k072-0165 12.7 µM 0.376779681832027 0.442478072220239 no 1453 0.353168670703466 405 5835461
SGTC_21 0849-0113 22.993 µM 0.376536634393596 0.442551814130432 no 1454 0.35325899282646 378 1560156
SGTC_22 0964-0034 14.468 µM 0.375114183899896 0.442983433151054 no 1455 0.353787774371585 403 138402
SGTC_742 0kpi-0133 140 µM 0.374187399084322 0.443264687079065 no 1456 0.354132449127865 405 2728852
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 0.373421022463949 0.44349728309194 no 1457 0.354417557788263 374 688662
SGTC_1152 3909-8331 15.9 µM 0.371062867303814 0.444213107137501 no 1458 0.355295353695701 407 16001939
SGTC_1208 2323-2347 50.3 µM 0.370365108041473 0.444424948752771 no 1459 0.355555234002325 409 5412760
SGTC_924 2046-0044 21.3 µM 0.36907222709964 0.444817512852464 no 1460 0.356036944716403 367 3623589
SGTC_2697 mebhydrolin 72.4 µM 0.368767566011652 0.444910026562521 no 1461 0.356150490994491 379 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_231 b-estradiol 524 µM 0.367180287529019 0.445392069665411 no 1462 0.35674227111816 365 450 A steroid.
SGTC_784 4579-0127 173 µM 0.365610138404398 0.445868990175694 no 1463 0.357328004396466 424 1948547
SGTC_2207 7258803 200 µM 0.364847294472784 0.446100726366965 no 1464 0.357612699530552 403 3666799
SGTC_2105 5350118 200 µM 0.364503794447161 0.446205080579011 no 1465 0.357740920426027 385 2133313
SGTC_1840 st055363 71 µM 0.364498709919075 0.446206625270427 no 1466 0.357742818487533 383 676033
SGTC_2436 5633522 8.09 µM 0.360322427023304 0.447475663270908 no 1467 0.359303014897214 389 5724242
SGTC_1073 triclabendazole 3.09 µM 0.360098322232289 0.447543776828244 no 1468 0.359386803707308 372 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_2190 6049624 200 µM 0.357603875551236 0.448302033446973 no 1469 0.360319888797947 400 2265554
SGTC_61 0978-8327 98.565 µM 0.356229350438859 0.448719939587716 no 1470 0.360834406644276 394 6150059 YHR072W ERG7
SGTC_366 0181-0206 4.31 µM 0.356075355664277 0.448766763210977 no 1471 0.36089206630956 384 274874
SGTC_2417 cerulenin 830 nM 0.355550724065603 0.448926287952819 no 1472 0.361088525808258 385 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_2791 5663188 71.43 µM 0.355471075486857 0.448950507420499 no 1473 0.361118355123983 435 54690634
SGTC_14 0354-0009 295 µM 0.35273549785629 0.44978245425003 no 1474 0.362143372165497 411 1713507
SGTC_1140 3229-1848 2.98 µM 0.352471534127408 0.449862742922071 no 1475 0.36224233145492 408 2849525
SGTC_3162 9099653 49.47 µM 0.351956401037302 0.450019434568173 no 1476 0.362435479972149 373 25237511
SGTC_2008 4012253 172 µM 0.351897859855697 0.45003724194363 no 1477 0.362457432133018 381 603940
SGTC_2591 skatole 100 µM 0.35188119265793 0.450042311881022 no 1478 0.362463682192181 409 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_2266 7929956 200 µM 0.350950315866576 0.450325485001741 no 1479 0.362812811319951 385 2967153
SGTC_1107 amlodipine 47 µM 0.349751133682474 0.450690313994293 no 1480 0.363262737573912 373 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_1476 4112-3294 3.34 µM 0.349268987627598 0.450837009772086 no 1481 0.363443689230263 409 704369
SGTC_1504 k297-0033 30 µM 0.348712731292925 0.451006262381306 no 1482 0.363652492677802 366 4388117
SGTC_3112 9123419 49.47 µM 0.347652769174058 0.451328802632688 no 1483 0.364050485615809 420 17015854
SGTC_428 3448-4153 16.5 µM 0.346284094393799 0.45174532984313 no 1484 0.364564610442165 369 3834874
SGTC_1157 4092-0394 27.6 µM 0.345539392803402 0.451971986361993 no 1485 0.364844450318011 366 3659885
SGTC_879 0831-1030 162 µM 0.345425661424911 0.452006602893257 no 1486 0.364887194013771 376 1549252
SGTC_172 1112-0046 2.638 µM 0.345067057338664 0.452115753958632 no 1487 0.365021979280312 381 2802135 YIL048W NEO1
SGTC_235 0330-0087 5 mM 0.344411902872285 0.452315177669505 no 1488 0.365268269311695 390 46494818 YHR062C RPP1
SGTC_3314 9135860 59.4275 µM 0.343039542927214 0.452732951852729 no 1489 0.365784356043275 396 25252478
SGTC_2707 st078556 66.6 µM 0.342901308166516 0.452775036224404 no 1490 0.365836353796685 388 17250899
SGTC_1431 4049-0260 9.09 µM 0.342176063622767 0.452995839305246 no 1491 0.366109198824818 395 3854841
SGTC_1089 terbinafine 2.25 µM 0.341756782406238 0.453123497481763 no 1492 0.36626696796068 402 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1049 3226-0134 66 µM 0.341594889555747 0.453172790150141 no 1493 0.366327891826118 377 5702385
SGTC_1597 7-benzyloxygramine 47.5 µM 0.341556965341713 0.45318433730983 no 1494 0.366342164034984 386 260807
SGTC_2829 7992743 58.44 µM 0.340137984409813 0.453616416801838 no 1495 0.366876308924826 380 16462845
SGTC_680 0417-1641 114 µM 0.339789461323787 0.453722550451225 no 1496 0.367007542436451 386 2835990
SGTC_2203 7227154 166.4 µM 0.337991517489134 0.454270119864174 no 1497 0.367684790040052 388 896304
SGTC_1222 0366-0074 1.18 µM 0.337872874195189 0.454306256118665 no 1498 0.367729494972603 426 286520
SGTC_2249 haloperidol 116.36 µM 0.337276339876696 0.45448795366369 no 1499 0.367954296951067 404 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2981 9013952 38.96 µM 0.33400534444296 0.455484429825754 no 1500 0.369187762881442 350 2996344
SGTC_1522 st012842 45.6 µM 0.33353833299613 0.455626723207133 no 1501 0.36936397939107 419 3491067 YOR116C RPO31
SGTC_2942 9052777 62.25 µM 0.33243937349753 0.455961586810703 no 1502 0.369778755855269 415 6469503
SGTC_1539 benzyladenosine 56 µM 0.331970524693714 0.456104459116697 no 1503 0.369955757979019 358 92208 A nucleotide analog.
SGTC_2083 5306046 65.942 µM 0.33001896262447 0.456699219443066 no 1504 0.370692816989409 378 539837
SGTC_3212 9128307 49.47 µM 0.329814069617338 0.456761668524789 no 1505 0.370770227838344 371 27243542
SGTC_13 0199-0087 65 µM 0.329255746023366 0.456931844685365 no 1506 0.370981195221491 396 4589825
SGTC_1463 k081-0032 34.1 µM 0.329096199421675 0.456980475693071 no 1507 0.371041488408264 389 977755
SGTC_1355 1499-0035 1.68 µM 0.328276675460803 0.457230282916345 no 1508 0.371351239080548 404 1548538
SGTC_1684 st024538 14.6195 µM 0.327886339072941 0.457349271168315 no 1509 0.371498801552351 387 6732859
SGTC_400 oxethazaine 37.5 µM 0.327834067716558 0.45736520560568 no 1510 0.371518563610656 405 4621 A local anesthetic.
SGTC_891 0929-0073 133 µM 0.327333166555259 0.45751790414268 no 1511 0.371707954815577 429 5603632
SGTC_1809 st050081 57.6 µM 0.32653425799592 0.457761462500658 no 1512 0.37201008714922 423 5036894
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.325731312250558 0.45800626763391 no 1513 0.372313825697485 367 6708561
SGTC_1226 3909-7979 35.4 µM 0.322167447014068 0.45909302334085 no 1514 0.37366292217072 405 6615510
SGTC_796 1234-0020 70.7 µM 0.318178953643681 0.460309626263434 no 1515 0.375174598203837 374 46495034
SGTC_7 0192-1582 4.227 µM 0.318163401511355 0.460314370837063 no 1516 0.375180496377616 406 252616
SGTC_965 1291-5240 308 µM 0.31806412102837 0.460344659007342 no 1517 0.375218149364711 403 2834598
SGTC_1604 st002052 72.4 µM 0.315733606812655 0.461055710503627 no 1518 0.376102357987913 373 6254834 YHR062C RPP1
SGTC_448 monastrol 171 µM 0.315678944725341 0.461072389682245 no 1519 0.37612310488313 413 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_476 mead acid 10 µM 0.315607346119922 0.46109423684633 no 1520 0.37615028054437 423 5312531 An omega 9 fatty acid.
SGTC_2930 9013230 14.89 µM 0.315142937524563 0.461235946515638 no 1521 0.376326564393815 407 2995857
SGTC_1861 st057647 17.4 µM 0.313815461196787 0.461641039812287 no 1522 0.376830600415941 457 688668
SGTC_187 1488-2104 32.728 µM 0.311843589139541 0.462242850555712 no 1523 0.377579697668353 414 2852859
SGTC_1793 st048256 72.231 µM 0.310906435158552 0.462528898150817 no 1524 0.377935876106998 432 672022
SGTC_2641 levomentholum 100 µM 0.310097429898553 0.462775846491243 no 1525 0.378243433322309 424 16666
SGTC_660 4031-1742 102 µM 0.309678196588985 0.462903822841845 no 1526 0.378402842417155 402 6738706
SGTC_2481 5478948 45.16 µM 0.308604161457264 0.463231703343763 no 1527 0.378811327450142 382 77792
SGTC_812 4251-0442 148 µM 0.306945450760686 0.463738122087722 no 1528 0.379442446547233 434 5723007
SGTC_1666 st014829 29 µM 0.306146903731737 0.463981946417799 no 1529 0.379746398617648 407 3858230
SGTC_2374 9071832 200 µM 0.304850941209502 0.464377677843529 no 1530 0.380239840737008 407 17381698
SGTC_1896 st058441 89 µM 0.304768354789194 0.464402897396263 no 1531 0.380271292412917 379 688759
SGTC_1530 rhein 70.4 µM 0.303900627346956 0.464667885396779 no 1532 0.380601799914202 412 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_894 0960-0238 55.9 µM 0.30354025095983 0.46477794232934 no 1533 0.380739088807301 426 6741907 YDL195W SEC31
SGTC_2569 tetrandrine 100 µM 0.303137105016497 0.464901064038038 no 1534 0.380892688976538 373 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_2874 9043904 71.43 µM 0.302604603630561 0.46506369634869 no 1535 0.381095602841638 405 4463428
SGTC_2077 5212015 200 µM 0.301781183377527 0.465315190250631 no 1536 0.381409437999955 427 780900
SGTC_2478 5763493 32.33 µM 0.300125428494644 0.465820942573824 no 1537 0.382040741811609 422 1365576 YLR208W SEC13
SGTC_650 1328-0195 38 µM 0.29802368126718 0.466463003206033 no 1538 0.382842544694217 430 2780821
SGTC_2486 5283202 22.39 µM 0.296277385600513 0.466996543766789 no 1539 0.383509127380722 404 1377751
SGTC_603 3794-0023 45.9 µM 0.295927552108938 0.467103434522044 no 1540 0.383642704693085 412 3802260
SGTC_1690 st023502 41.2 µM 0.293314939665219 0.467901786265989 no 1541 0.38464071769462 445 24207482
SGTC_855 0428-0020 25 µM 0.290608679605167 0.468728890583298 no 1542 0.385675310545579 402 6812414
SGTC_675 1309-0189 238 µM 0.289704645366093 0.469005217500037 no 1543 0.38602110108902 373 4246530
SGTC_1183 1254-0324 198 µM 0.289556133271098 0.469050613107396 no 1544 0.386077915214762 403 5799357
SGTC_1965 Pectolinarigenin 58.4 µM 0.288979538210112 0.469226864398964 no 1545 0.386298518000141 403 5320438 An anti-inflammatory.
SGTC_2860 9025725 38.96 µM 0.288899415168601 0.469251356570544 no 1546 0.386329175641084 435 40546248
SGTC_3106 9121286 49.47 µM 0.288767998997771 0.469291528380372 no 1547 0.386379461211984 374 15943471
SGTC_3029 9088683 49.47 µM 0.288388967893342 0.469407393842581 no 1548 0.386524505765696 388 25236615
SGTC_1571 st070080 73.4 µM 0.28601604801184 0.470132826729615 no 1549 0.387432915117126 397 4315245
SGTC_942 3253-1115 227 µM 0.284744695228989 0.470521536974931 no 1550 0.387919872798418 425 46497897
SGTC_751 0833-0568 350 µM 0.283369648981215 0.470941982627265 no 1551 0.38844674593928 435 6954252
SGTC_1193 1488-0126 41.5 µM 0.283191345256425 0.470996504649286 no 1552 0.388515081204446 406 1384710
SGTC_3227 9130768 49.47 µM 0.281314309145846 0.471570500793435 no 1553 0.389234668090025 430 17720899
SGTC_1409 3909-8004 61.9 µM 0.280987560511871 0.471670426333499 no 1554 0.389359970451774 402 2119279
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.280848652324104 0.471712907466936 no 1555 0.389413242787666 401 6312947
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.280400499649737 0.471849964456147 no 1556 0.389585126876605 412 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_755 1995-0008 37.3 µM 0.280351500050463 0.471864950037326 no 1557 0.389603921451072 401 689533
SGTC_3158 9100007 49.47 µM 0.279806153533269 0.472031736421828 no 1558 0.389813115186162 400 19297233
SGTC_661 1304-0007 33.6 µM 0.279796167336564 0.472034790602201 no 1559 0.389816946167261 423 3117130
SGTC_2364 9055074 200 µM 0.279521711529568 0.472118730863471 no 1560 0.389922239189999 413 6470630
SGTC_105 0111-0055 734.78 µM 0.279507518664497 0.472123071679089 no 1561 0.389927684401698 412 5179370
SGTC_354 2783-3500 4.88 µM 0.278167588503294 0.472532897346568 no 1562 0.390441856988066 396 6740761
SGTC_1650 st011916 45.8 µM 0.277884247310051 0.472619562687413 no 1563 0.390550608335434 442 242528
SGTC_359 0081-0058 15.9 µM 0.275720182618282 0.473281525857317 no 1564 0.391381496401212 463 3494159
SGTC_107 0358-0022 2.6945 µM 0.275702516707409 0.473286929967875 no 1565 0.391388281235949 435 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_2828 7998861 71.43 µM 0.275497426325775 0.473349668733921 no 1566 0.391467051420847 438 2988188
SGTC_1313 1220-0047 237 µM 0.273981620766993 0.473813386011492 no 1567 0.392049372963516 418 3528706
SGTC_2705 st078069 42.8 µM 0.273267314942405 0.47403191975049 no 1568 0.3923238691776 421 1530061
SGTC_1352 1496-0991 99 µM 0.270955861373539 0.474739135890703 no 1569 0.39321249012052 462 3000039
SGTC_801 0866-0028 10.1 µM 0.269111243188042 0.475303575528376 no 1570 0.393922039339254 408 6849771
SGTC_3313 9133968 57.047 µM 0.268821179270874 0.475392337498851 no 1571 0.394033647185559 450 1494643
SGTC_2129 girgensonine 121.053 µM 0.268707055767806 0.475427260574723 no 1572 0.394077560853449 456 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1227 3909-8010 46.6 µM 0.267976161133699 0.475650927020283 no 1573 0.394358834252505 426 15982272
SGTC_2243 6634756 200 µM 0.267915168120197 0.475669592289024 no 1574 0.394382308955004 376 885676
SGTC_642 0335-0876 158 µM 0.267814198476521 0.475700491445864 no 1575 0.394421170516903 439 6812350
SGTC_1725 st036284 20.55 µM 0.267718734277869 0.475729705937566 no 1576 0.394457914089688 409 707914
SGTC_1288 0973-0013 65.5 µM 0.267684828647848 0.47574008196082 no 1577 0.394470964380563 418 4315430
SGTC_1053 3366-3204 134 µM 0.265347728896405 0.476455335820221 no 1578 0.395370799736843 409 3632071 YPR165W RHO1
SGTC_2630 antimycin a 100 µM 0.264944611145958 0.47657871506649 no 1579 0.395526065603886 414 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_1217 1183-1422 255 µM 0.263266748661196 0.477092269923829 no 1580 0.396172493320295 419 2849664
SGTC_2397 5161689 200 µM 0.263221306223088 0.477106179334979 no 1581 0.396190004844431 416 2259942
SGTC_1378 2093-0007 380 nM 0.26139089430871 0.477666470514602 no 1582 0.396895539154238 453 3618014
SGTC_2423 st077119 87.2 µM 0.261158489104096 0.477737613194985 no 1583 0.39698514420175 395 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_74 000s-0487 160.283 µM 0.261065476782723 0.477766085845113 no 1584 0.397021007115017 355 677548
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.260187165133311 0.478034957522814 no 1585 0.397359702075825 439 4213774
SGTC_2900 5328528 85.29 µM 0.257444447049357 0.478874631285945 no 1586 0.39841784751883 450 795359
SGTC_2413 inermin 26.06 µM 0.257162633657574 0.478960912867703 no 1587 0.398526614089071 459 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_440 fluspirilene 35.1 µM 0.256285054347035 0.479229603809787 no 1588 0.398865368436015 433 3396 An atypical antipsychotic.
SGTC_683 panaxydol 45 µM 0.245913241711232 0.482405852753163 no 1589 0.402874696568058 425 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_292 k038-0015 474 µM 0.244018885966057 0.482986104102309 no 1590 0.403608096544546 415 46368540
SGTC_3071 9117417 49.47 µM 0.243922008877133 0.483015779054546 no 1591 0.403645611652378 448 45595590 YGL055W OLE1
SGTC_3137 9097352 49.47 µM 0.243139270364918 0.483255547416568 no 1592 0.403948755228078 457 44120435
SGTC_324 1315-0088 19.6 µM 0.241850053794463 0.483650473233334 no 1593 0.404448176301377 458 6787421
SGTC_1740 st038286 13.222 µM 0.241516860757451 0.483752542907514 no 1594 0.4045772751047 407 716786
SGTC_141 0443-0274 32.331 µM 0.240863578668619 0.483952671091972 no 1595 0.404830425589637 433 1627241
SGTC_46 0329-0187a 2.197 µM 0.240628254935217 0.484024761787667 no 1596 0.404921624625147 443 46494817
SGTC_578 3460-0051 92 µM 0.239313609879147 0.484427508763809 no 1597 0.405431206412017 470 2876744
SGTC_2467 5474540 200 µM 0.238471810932406 0.484685405738955 no 1598 0.40575758818552 401 5413519
SGTC_2222 6885208 172.143 µM 0.238464914638824 0.484687518542323 no 1599 0.405760262283159 422 609514
SGTC_588 3970-1144 52.9 µM 0.237948690192817 0.484845674387004 no 1600 0.405960445265455 430 1888707
SGTC_1334 1486-0610 236 µM 0.237458543730942 0.484995842918353 no 1601 0.406150538412726 422 3742339
SGTC_731 3966-0296 387 µM 0.237362239976911 0.485025348213928 no 1602 0.406187890429997 429 660956
SGTC_310 1273-0058 1.06 µM 0.237096156078502 0.485106870737606 no 1603 0.406291097182736 423 2734232
SGTC_438 sphingosine 6.67 µM 0.23563153124332 0.485555612109056 no 1604 0.406859301946061 420 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_276 colchicine 750 µM 0.234642992680462 0.485858497417581 no 1605 0.407242918814351 455 2833 A microtubule depolymerizer.
SGTC_482 fipronil 114 µM 0.234080806340428 0.486030753309258 no 1606 0.407461123176609 428 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_995 3931-2021 34.6 µM 0.233404938519473 0.486237845058094 no 1607 0.407723489342919 442 730143
SGTC_3241 9133421 49.47 µM 0.233351720501084 0.486254151677795 no 1608 0.407744149886514 460 17018221
SGTC_1495 4469-0029 237 µM 0.23325209446375 0.486284678315939 no 1609 0.407782827854137 433 793680
SGTC_143 4032-1194 15.74 µM 0.232814999340802 0.486418610562951 no 1610 0.407952532574254 428 1806963
SGTC_3047 9092122 49.47 µM 0.232655205559466 0.486467574064392 no 1611 0.408014577750518 432 17173831
SGTC_2800 7887935 81.82 µM 0.232129055081358 0.486628796855545 no 1612 0.408218889223269 433 2961002
SGTC_2958 9077254 16.72 µM 0.231974179510467 0.486676254175321 no 1613 0.40827903429556 412 16457351
SGTC_2278 7948257 134.34 µM 0.231641809482271 0.48677810038087 no 1614 0.408408115652603 454 1247028
SGTC_798 1287-0182 476 µM 0.230895231513939 0.487006873039088 no 1615 0.408698097677294 459 1649755
SGTC_1141 3253-0389 52.6 µM 0.229795968232921 0.487343726238453 no 1616 0.409125158891311 466 5402031
SGTC_1149 3909-7961 23.3 µM 0.229458578394025 0.487447116255783 no 1617 0.409256255716496 428 735261
SGTC_1045 1348-1485 165 µM 0.2286967296788 0.487680580889954 no 1618 0.409552318387304 407 6810614
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.227935380108971 0.487913896781233 no 1619 0.409848238622322 419 688761
SGTC_420 mitomycin C 81.9 mM 0.227862871802973 0.487936117198648 no 1620 0.40987642372548 419 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1072 oxiconazole 14.9 nM 0.227407173693405 0.488075768291407 no 1621 0.41005357130303 442 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_506 n9-isopropylolomoucine 153 µM 0.226480616781417 0.488359721041719 no 1622 0.410413816584829 454 6610355
SGTC_1915 st067105 30.6 µM 0.226053905491399 0.488490493031617 no 1623 0.41057974735789 458 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_244 nsc-207895 1.295 µM 0.224555254160156 0.488949786622499 no 1624 0.411162638921178 436 42640
SGTC_2442 5158906 48.48 µM 0.224266675147701 0.489038229503075 no 1625 0.41127490258487 462 1893835
SGTC_3192 9110362 49.47 µM 0.223836802345674 0.489169976703351 no 1626 0.411442146150108 444 16649480
SGTC_2201 6605497 169.863 µM 0.223545977396071 0.48925910925876 no 1627 0.411555301775028 460 670741
SGTC_2226 7298446 200 µM 0.223298401382362 0.489334987225113 no 1628 0.411651635685257 457 3283010
SGTC_2811 7967822 32.47 µM 0.222243365722078 0.489658342554191 no 1629 0.41206221857649 435 2232244
SGTC_490 phenamil 164 µM 0.222213189479513 0.489667591298826 no 1630 0.412073963530564 441 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_829 1635-0120 117 µM 0.222091355922051 0.489704932235556 no 1631 0.412121383407253 432 285054
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 0.221178979467895 0.489984570611443 no 1632 0.412476537956106 472 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_190 3970-0790 3.722 µM 0.22088642283042 0.490074238664189 no 1633 0.412590434669658 446 2832352
SGTC_3248 9135562 49.47 µM 0.220590787229129 0.490164850923068 no 1634 0.412705537547301 410 17650701
SGTC_1843 st055809 45.5 µM 0.220584379507342 0.490166814894286 no 1635 0.412708032415292 425 16413835
SGTC_2620 irigenin 100 µM 0.220259639980055 0.490266348098123 no 1636 0.412834475456282 480 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_2851 9015922 71.43 µM 0.220028265183886 0.490337265227131 no 1637 0.412924570817159 476 2996893
SGTC_1697 st025554 27.742 µM 0.219857528670228 0.490389596720942 no 1638 0.412991057092402 432 1269519
SGTC_1204 4049-0315 18.3 µM 0.217931637968884 0.490979901951329 no 1639 0.413741188005473 414 588402
SGTC_1814 st052110 31.539 µM 0.216263278410315 0.491491287264915 no 1640 0.4143912656608 453 674163
SGTC_456 gingerol 170 µM 0.21614619973372 0.491527174737684 no 1641 0.414436894291238 452 442793 A herb.
SGTC_858 0438-0351 2.77 µM 0.216100769820011 0.491541100133861 no 1642 0.414454599830916 439 2799119
SGTC_599 1935-0052 86.5 µM 0.216074202197753 0.491549243774302 no 1643 0.414464954192417 435 9557311
SGTC_2975 9084847 53.72 µM 0.214835752852849 0.491928863312947 no 1644 0.414947688459179 410 27211724
SGTC_1669 st015249 58.4 µM 0.214803739854444 0.491938676295291 no 1645 0.414960168488664 461 722793
SGTC_1986 st071812 45 µM 0.214489276321067 0.492035069433305 no 1646 0.415082764319839 470 11838594
SGTC_1909 st060837 51.5 µM 0.214328709963392 0.492084288340915 no 1647 0.415145365439142 449 678937
SGTC_1997 st073024 93.8 µM 0.213000209159789 0.492491522399612 no 1648 0.415663399770113 473 686268
SGTC_867 0518-0118 155 µM 0.211374663050251 0.492989822306012 no 1649 0.416297463020416 469 6848158
SGTC_2902 5787006 60.46 µM 0.210852702958325 0.493149827916274 no 1650 0.41650110594594 432 591003
SGTC_667 1498-1044 59 µM 0.209652086604602 0.493517878111589 no 1651 0.416969611851406 475 6739982
SGTC_555 4296-0685 37 µM 0.207503225313353 0.494176627352061 no 1652 0.417808437026936 460 2908540 YHR072W ERG7
SGTC_1445 4239-0156 97.7 µM 0.20644719891572 0.49450036594604 no 1653 0.418220802701291 470 4008346
SGTC_636 0kpi-0074 126 µM 0.20582645456432 0.494690664885019 no 1654 0.418463237930938 446 616434
SGTC_2919 7978188 46.38 µM 0.205753018207801 0.49471317803529 no 1655 0.418491920967636 439 2980291
SGTC_1885 st057546 99.9 µM 0.20417668858537 0.49519643233646 no 1656 0.41910771372365 420 702008
SGTC_466 geldanamycin 89.2 µM 0.203287448153068 0.495469049326941 no 1657 0.419455182812763 455 5288382 HSP90 inhibitor.
SGTC_1626 st003712 1.76 µM 0.202597899209603 0.49568044778794 no 1658 0.419724666069722 456 24207035
SGTC_2658 polymyxin b sulfate 77.05 µM 0.200666474468581 0.49627258057757 no 1659 0.420479687977413 444 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_3344 9148862 3.898 µM 0.20036125814515 0.496366154044445 no 1660 0.420599028308945 455 4905352
SGTC_98 0074-0023 107.663 µM 0.200165577111309 0.4964261461993 no 1661 0.420675543913588 462 3563821
SGTC_205 1486-1330 71.903 µM 0.199982651797314 0.496482227761505 no 1662 0.420747074460579 453 4118834
SGTC_1012 4112-3522 18 µM 0.198001806850447 0.497089522884309 no 1663 0.421521825028431 445 3112398
SGTC_3278 9139605 49.47 µM 0.196769105633581 0.497467452696205 no 1664 0.422004114283591 445 7958859
SGTC_2923 7992654 58.14 µM 0.195934054154646 0.497723469694823 no 1665 0.422330891238069 470 2985126
SGTC_1296 1068-0102 11.9 µM 0.195802235552912 0.497763883821901 no 1666 0.422382480113107 468 767053
SGTC_75 0159-0059 199.013 µM 0.195549761429862 0.497841289662634 no 1667 0.42248129276741 478 5377270
SGTC_2755 lomerizine 42.69 µM 0.192440513168815 0.498794557377999 no 1668 0.423698580243078 437 3949 A calcium channel blocker.
SGTC_228 caffeine 993.056 µM 0.192099421272586 0.498899133620757 no 1669 0.42383216411349 444 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_2614 arthonioic acid 13.39 µM 0.191589747351644 0.499055395999321 no 1670 0.424031787082935 436 6710684
SGTC_2587 piperic acid 92.2 µM 0.191360678121972 0.499125627035289 no 1671 0.424121512524379 470 5370536
SGTC_387 norethindrone acetate 66.7 µM 0.190686138560279 0.499332436332469 no 1672 0.424385749623957 452 541197
SGTC_2729 fluphenazine 10.66 µM 0.190564782102293 0.499369643427711 no 1673 0.42443329214934 467 3372 An atypical antipsychotic.
SGTC_2409 alverine citrate 63.97 µM 0.18977126503289 0.499612930684768 no 1674 0.424744186937804 381 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_3025 9087895 49.47 µM 0.1887978043452 0.4999113876913 no 1675 0.425125646387279 449 17173641
SGTC_96 0929-0093 37.281 µM 0.188508782541573 0.5 no 1676 0.425238915731674 416 6991579
SGTC_2564 betulinic acid 100 µM 0.187723993278496 0.499759388447767 no 1677 0.425546510362186 434 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_770 0389-1121 67.2 µM 0.187272933229092 0.49962109625002 no 1678 0.425723321845617 442 6753108
SGTC_3320 9137005 35.139 µM 0.186242033941914 0.499305029156287 no 1679 0.426127481118415 478 4908713
SGTC_1014 4130-3005 69.3 µM 0.185787095211554 0.499165547993368 no 1680 0.426305862437442 440 743608
SGTC_475 α-linolenic acid 10 µM 0.183781265347471 0.49855057545983 no 1681 0.427092526941009 449 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1630 st005209 31.3 µM 0.183459163576439 0.498451821732808 no 1682 0.427218878835252 478 3367314
SGTC_49 0717-0965 32.132 µM 0.18337663921258 0.498426520463475 no 1683 0.427251252134071 471 5889349 YGL099W LSG1
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.183004408769507 0.498312397849973 no 1684 0.427397279670599 498 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_3131 9127911 49.47 µM 0.182667409746838 0.498209077002129 no 1685 0.427529494356218 437 45595681
SGTC_389 tpck 16.7 µM 0.182313373501704 0.498100532825713 no 1686 0.427668402014784 423 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_2877 9040724 71.43 µM 0.182285040045819 0.498091846061116 no 1687 0.427679519156985 447 6463895
SGTC_2593 nobiletin 86.24 µM 0.181880214188514 0.497967730454346 no 1688 0.427838366146902 426 72344 An anti-infammatory.
SGTC_1682 st012968 530 nM 0.179532970386673 0.497248092959042 no 1689 0.42875961562502 445 24207270
SGTC_2470 5664817 21.68 µM 0.179437249858015 0.497218746338686 no 1690 0.428797192423568 475 2859561
SGTC_1329 1447-1697 50.6 µM 0.177349727689083 0.496578744273163 no 1691 0.429616846381853 450 2840515
SGTC_3014 9081533 49.47 µM 0.176855406987191 0.496427194406354 no 1692 0.429810983227032 478 21367265
SGTC_2477 5967686 25.23 µM 0.174975057236767 0.495850717774764 no 1693 0.430549616326767 447 776118
SGTC_65 0798-0905 34.986 µM 0.173899208165956 0.495520888355557 no 1694 0.430972337469884 490 3602145
SGTC_439 amiodarone 34.4 µM 0.173868142393429 0.495511364382147 no 1695 0.430984544967867 465 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_278 4092-0821 23.9 µM 0.173848620875221 0.495505379583941 no 1696 0.43099221610954 468 877900
SGTC_427 1354-0053 47.3 µM 0.173732538605961 0.495469791750011 no 1697 0.431037832132748 447 6813657
SGTC_1942 st076330 65.2 µM 0.173638992632475 0.495441112990138 no 1698 0.431074592897615 476 24208414
SGTC_2062 5245942 200 µM 0.173113607603566 0.495280044061395 no 1699 0.431281064558408 457 1376160
SGTC_378 3970-0959 8.33 µM 0.173082148834694 0.495270399672552 no 1700 0.431293428172268 476 6615653
SGTC_589 1227-0070 34.1 µM 0.172503574442712 0.495093025257703 no 1701 0.431520825743286 465 2841384
SGTC_1402 3909-7673 35.9 µM 0.172432339498782 0.495071186720991 no 1702 0.431548824842873 460 5328014
SGTC_2533 agelasine 13.65 µM 0.172367362052111 0.495051266561604 no 1703 0.431574364715101 479 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_1659 st012954 42.1 µM 0.167224773152011 0.493474744455515 no 1704 0.433596596355507 463 24207262
SGTC_499 genistein 192 µM 0.166501959298924 0.493253164831253 no 1705 0.433880970698269 496 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_48 0382-0018 55 µM 0.166272706892178 0.49318288760845 no 1706 0.433971171895657 414 762596
SGTC_2353 9059630 146.67 µM 0.165914544833773 0.493073093613884 no 1707 0.434112100509363 452 4779114
SGTC_328 k915-0120 63.5 µM 0.164336314417652 0.492589296018414 no 1708 0.434733197758573 444 6624543
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.163527969603685 0.492341506670511 no 1709 0.435051376493421 435 4174840
SGTC_1139 k015-0024 46.9 µM 0.162824844142405 0.49212597357547 no 1710 0.435328173253373 477 2766652
SGTC_2736 butenafine 14.65 µM 0.162637625075248 0.49206858462208 no 1711 0.435401880428576 473 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.161686026636997 0.491776890194677 no 1712 0.43577655443752 462 688801
SGTC_1631 benzylvanillin 81.9 µM 0.161100186702064 0.491597314266523 no 1713 0.436007246599375 441 75506
SGTC_637 1181-0519 7.26 µM 0.161032684933649 0.491576623241048 no 1714 0.436033828859069 485 6252091 YGR060W ERG25
SGTC_340 k038-0059 454 µM 0.161013495033215 0.491570741047901 no 1715 0.436041385912608 468 23733424
SGTC_3081 9117243 49.47 µM 0.159820778497277 0.491205146706222 no 1716 0.43651112779993 467 45595589
SGTC_3049 9092223 49.47 µM 0.1591702374312 0.491005744387999 no 1717 0.436767375989941 472 8623917
SGTC_318 1488-0629 67.2 µM 0.158603051360629 0.490831893679492 no 1718 0.436990812295591 467 3662576
SGTC_1479 0549-0158 134 µM 0.158036548886797 0.490658254241732 no 1719 0.437213999370682 454 5440202
SGTC_1285 0929-0069 65.5 µM 0.157984128520706 0.490642186893563 no 1720 0.437234652627348 451 1206237
SGTC_127 0180-0333 59.125 µM 0.156744227758421 0.490262149826972 no 1721 0.437723214580669 470 771601
SGTC_843 0310-0051 143 µM 0.155744479454797 0.489955727359697 no 1722 0.438117217700679 491 2065037
SGTC_1487 3970-0795 2.82 µM 0.155736581552066 0.489953306678936 no 1723 0.438120330527185 457 3765103
SGTC_866 0495-0101 262 µM 0.155363086790659 0.489838832208372 no 1724 0.438267541620324 479 635694
SGTC_932 2857-0803 154 µM 0.155031030486905 0.489737059141937 no 1725 0.438398427126576 477 674898
SGTC_1640 st009078 66.4 µM 0.154730404524089 0.489644919843786 no 1726 0.438516929653946 481 690618
SGTC_929 2805-0021 398 µM 0.154489131362095 0.489570972073262 no 1727 0.438612040129653 465 3098024
SGTC_3098 9119039 49.47 µM 0.153913631613046 0.489394588704792 no 1728 0.438838917853844 481 17161528
SGTC_2014 4013930 200 µM 0.151800955639441 0.488747098379996 no 1729 0.439671964189732 490 64556
SGTC_937 3122-0005 46.7 µM 0.151271688599943 0.488584893849654 no 1730 0.439880700740038 490 759535
SGTC_827 3253-0474 693 µM 0.150484356088693 0.488343603466043 no 1731 0.440191246112159 456 5402065
SGTC_1180 1193-0155 285 µM 0.150476590448688 0.488341223585098 no 1732 0.440194309275506 465 2921347
SGTC_877 0771-0151 33.1 µM 0.149741687366102 0.488116004908955 no 1733 0.44048420859777 481 6166523
SGTC_1228 0124-0032 52.5 µM 0.149133366264841 0.487929581458246 no 1734 0.440724198904557 460 X1228
SGTC_1013 4112-3890 241 µM 0.1481151326768 0.487617543923963 no 1735 0.44112595351055 485 705171
SGTC_2970 9090938 41.86 µM 0.147567794071496 0.487449815208549 no 1736 0.441341936691534 457 17217104
SGTC_528 3492-0019 172 µM 0.147267532960445 0.487357802887657 no 1737 0.441460428987514 459 2869262
SGTC_1022 4477-0945 21.3 µM 0.147217931645771 0.487342603074869 no 1738 0.441480003700793 464 4648966
SGTC_982 1491-0518 27.5 µM 0.147195771675168 0.48733581238571 no 1739 0.441488748980332 451 3091256
SGTC_2838 9002687 71.43 µM 0.146014154616216 0.486973723673877 no 1740 0.44195510720932 474 6457060
SGTC_17 0960-0276 49.807 µM 0.145654218524004 0.486863428811392 no 1741 0.442097182076253 475 6821114
SGTC_2082 5219693 150 µM 0.145458199551406 0.486803363332613 no 1742 0.44217455830519 486 2834649
SGTC_2335 9018011 154.17 µM 0.144790375690744 0.486598726417827 no 1743 0.442438190617589 481 6458208
SGTC_3172 9105863 49.47 µM 0.144498210939892 0.486509201383053 no 1744 0.442553534544722 485 2348785
SGTC_853 0419-0306 21 µM 0.142816653429614 0.485993952394628 no 1745 0.443217492186451 489 762713
SGTC_1480 1070-0044 41.2 µM 0.141418584422183 0.485565585380044 no 1746 0.443769636782483 475 3124987
SGTC_3340 9146634 11.102 µM 0.140568897295828 0.485305250158435 no 1747 0.444105260288838 491 4907387
SGTC_1118 chelidonine 707.474 nM 0.140275044731133 0.485215218267287 no 1748 0.444221340387581 491 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_3294 9122953 26.2835 µM 0.138540120167411 0.484683679667319 no 1749 0.44490678199925 498 16459826
SGTC_1672 st016598 6.51 µM 0.138489378959339 0.484668134202934 no 1750 0.44492683154829 487 4665860 YNL267W PIK1
SGTC_222 nsc-310342 10.666 µM 0.133866767236177 0.483252016275578 no 1751 0.446753964805705 500 432556
SGTC_775 4577-0580 57.3 µM 0.133064984761598 0.483006414537631 no 1752 0.44707099347615 484 2006902
SGTC_773 4358-1457 44.6 µM 0.131457788879703 0.482514118347319 no 1753 0.447706588162796 490 1186886
SGTC_357 1325-0123 420 µM 0.131079143451367 0.482398140256374 no 1754 0.447856349954683 489 1098503
SGTC_994 3910-0338 138 µM 0.130682846996035 0.482276757298115 no 1755 0.448013101039263 488 3479481
SGTC_3208 9114115 49.47 µM 0.129877489790755 0.482030086837058 no 1756 0.448331676983922 490 650895
SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.12926652052826 0.481842959464221 no 1757 0.448573380938784 501 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_2857 9024691 58.44 µM 0.128925745817352 0.481738588884323 no 1758 0.448708202231435 489 16478292
SGTC_2236 dapsone 200 µM 0.128466130654642 0.481597822496713 no 1759 0.448890049958502 488 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_208 k072-0098 12.366 µM 0.127850234845347 0.48140919561816 no 1760 0.449133747287367 488 5948901
SGTC_2859 9028643 45.46 µM 0.126798364586086 0.481087054991329 no 1761 0.449549995081036 476 17151580
SGTC_405 ebelactone b 50 µM 0.126585192568027 0.481021771472783 no 1762 0.449634358636231 487 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_1126 isoteolin 1.0172 µM 0.126404672781133 0.480966488034858 no 1763 0.449705801739605 459 133323
SGTC_1951 sophoraflavanone G 9.2 µM 0.126128697587828 0.480881972481556 no 1764 0.449815025738375 478 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_311 1315-0136 58 µM 0.125727129855558 0.480758996590883 no 1765 0.449973962875122 483 6759207
SGTC_3312 9133330 71.43 µM 0.125464314783677 0.480678513232436 no 1766 0.450077987220024 483 17617324
SGTC_2897 9048598 12.99 µM 0.124620492604058 0.480420110093833 no 1767 0.450412002059305 479 6467404
SGTC_2843 9000894 45.46 µM 0.122919448496892 0.479899225542054 no 1768 0.451085442370736 477 2242070
SGTC_281 1672-3440 14.9 µM 0.122555064402066 0.479787650243285 no 1769 0.45122971976003 500 6833000
SGTC_1277 0873-0036 22 µM 0.121576069000781 0.479487887330745 no 1770 0.451617383522106 467 5965735
SGTC_2422 chlorphenesin carbamate 384.24 µM 0.121156652052295 0.479359467748333 no 1771 0.451783478883852 467 2724 A muscle relaxant with antifungal properties.
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.121135036156921 0.479352849322527 no 1772 0.451792039329496 489 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_3020 9089140 49.47 µM 0.120282848889741 0.479091928382373 no 1773 0.452129545034002 477 17217859
SGTC_1398 3558-0053 112 µM 0.120277116713808 0.479090173346777 no 1774 0.452131815359091 479 4532369
SGTC_2770 toltrazuril 17.5 µM 0.11943523890642 0.478832417792982 no 1775 0.452465272241162 487 68591 Kills coccidiodes.
SGTC_2537 larixol 68.93 µM 0.118702658626687 0.478608132780349 no 1776 0.452755465081671 512 6708759
SGTC_2173 5763948 167 µM 0.118633431056991 0.478586938583685 no 1777 0.452782889110769 503 2867177
SGTC_678 1218-2179 85.9 µM 0.118171501173901 0.478445519127165 no 1778 0.452965885239364 512 6820081 YOR116C RPO31
SGTC_122 0236-0016 402.397 µM 0.117770128545976 0.478322641427679 no 1779 0.453124899382072 501 6808838
SGTC_1991 st073000 8.92 µM 0.117138435270561 0.478129256691989 no 1780 0.453375176217985 491 4301969 YIL048W NEO1
SGTC_2053 5265679 138 µM 0.116700578005719 0.477995215365735 no 1781 0.453548666112237 494 764595
SGTC_2505 galangin 7.89 µM 0.116075993034509 0.477804015363324 no 1782 0.453796157483386 503 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_254 nsc-64875 3.808 µM 0.115776815403573 0.477712431931435 no 1783 0.453914712778587 499 56993
SGTC_3053 9095903 49.47 µM 0.115719543435124 0.477694900128362 no 1784 0.453937408443729 507 17174018
SGTC_301 4119-0100 24.5 µM 0.115066126990677 0.477494882680696 no 1785 0.454196354137301 499 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_3203 9113543 49.47 µM 0.113030838337662 0.476871896592657 no 1786 0.455003053208265 468 17018012
SGTC_2665 lovastatin 100 µM 0.11295531337321 0.476848780064397 no 1787 0.455032991580369 483 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_2622 2-methoxyxanthone 59.94 µM 0.111741871902684 0.476477383089772 no 1788 0.455514039117557 500 71034 A hepatoprotective.
SGTC_1299 1079-1439 3.74 µM 0.110583834277509 0.476122962571921 no 1789 0.455973183615466 472 323161
SGTC_3338 9144300 39.5675 µM 0.109722720578275 0.475859428646878 no 1790 0.456314640396447 479 4901274
SGTC_627 1391-0720 175 µM 0.107661693924597 0.47522871828791 no 1791 0.457132028328452 513 997839
SGTC_1259 0671-0132 43 µM 0.107563232023001 0.475198588757375 no 1792 0.457171082157748 472 X1259
SGTC_550 4123-0385 25.7 µM 0.106995580205376 0.475024888984742 no 1793 0.457396243056378 481 5731123
SGTC_1616 st002734 56.1 µM 0.106309535191526 0.474814967583464 no 1794 0.457668383237907 474 4026101
SGTC_2431 5490079 200 µM 0.106108464461783 0.474753443716433 no 1795 0.457748147696542 502 5722345
SGTC_201 4262-0159 12.803 µM 0.104874033210262 0.474375744185787 no 1796 0.458237881908872 502 1341029
SGTC_207 4185-0010 4.486 µM 0.103318789218986 0.473899918252321 no 1797 0.458854981890508 483 3761753
SGTC_1122 capsaicin 818.572 nM 0.102688784271419 0.473707179187614 no 1798 0.459104987719367 515 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_604 1000-0114 314 µM 0.10232613626739 0.473596236121483 no 1799 0.459248905223812 498 1572745
SGTC_5 0352-0601 109.883 µM 0.101256229361732 0.473268936889571 no 1800 0.459673530729233 476 762456
SGTC_219 mitoxanthrone 164.414 µM 0.101027182948997 0.47319887078049 no 1801 0.459764440846948 482 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_1368 1852-0141 284 µM 0.098175561770203 0.472326619874593 no 1802 0.460896443792512 490 2838987
SGTC_1523 st012844 44.7 µM 0.0971176071272419 0.472003047338981 no 1803 0.461316499245644 454 4274103
SGTC_2371 9071574 200 µM 0.096958942974367 0.471954521929668 no 1804 0.461379499765281 509 45596039
SGTC_496 calpeptin 138 µM 0.0968472264561621 0.471920355105882 no 1805 0.461423859444786 479 73364 A calpain inhibitor.
SGTC_2751 anetholtrithion 17.25 µM 0.0962323373264106 0.471732304180857 no 1806 0.461668024257978 498 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_2821 7996764 71.43 µM 0.0954176271080013 0.4714831518863 no 1807 0.461991557774839 488 2987135
SGTC_2892 9047358 58.44 µM 0.095274731420999 0.47143945309315 no 1808 0.462048306371156 491 6466771
SGTC_82 0054-0107 293.755 µM 0.0951769997183314 0.471409566052757 no 1809 0.462087119302767 514 3104697
SGTC_1294 1000-1494 117 µM 0.0951261971879804 0.47139403034612 no 1810 0.46210729503922 493 712797 YDL207W GLE1
SGTC_1364 1653-0028 37.6 µM 0.0946677580374734 0.47125383898279 no 1811 0.462289364143445 519 5718652
SGTC_1872 amphotericin b 148 nM 0.094495917113339 0.471201290693538 no 1812 0.462357612802939 508 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_1021 4476-0760 85.3 µM 0.0942559821808911 0.471127920359176 no 1813 0.462452907658365 483 746768
SGTC_2514 salinomycin 42.74 µM 0.094002351568025 0.471050363052183 no 1814 0.462553644364449 500 23682228 A polyether potassium ionophore.
SGTC_1807 st050092 58.9 µM 0.0926942301309158 0.470650372150513 no 1815 0.463073240482611 489 5008496
SGTC_429 1112-0049 25.5 µM 0.0920520132835053 0.470454009071457 no 1816 0.46332835717767 471 2836170
SGTC_206 4546-0025 72.014 µM 0.0918000786202344 0.470376979936952 no 1817 0.463428440798651 514 6620745 YIL048W NEO1
SGTC_2258 7960471 200 µM 0.0917727782399216 0.470368632900134 no 1818 0.463439286292991 512 2974708
SGTC_1461 k072-0203 53.8 µM 0.0917577161674189 0.470364027707087 no 1819 0.463445269943686 500 5418714
SGTC_2655 perillic acid 100 µM 0.0913436867029463 0.470237440731543 no 1820 0.463609753044738 511 5702197 An apoptosis inducer.
SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.0911023205143691 0.470163645883132 no 1821 0.463705644404467 499 5377381
SGTC_1767 st044992 70.3 µM 0.0909403878137955 0.47011413745541 no 1822 0.463769979149443 522 9600693
SGTC_635 k038-0028 24.7 µM 0.0906965433653921 0.470039586644963 no 1823 0.463866858653777 510 4035102
SGTC_988 1497-1057 103 µM 0.0903221709349712 0.469925131426995 no 1824 0.464015601149515 511 3533044
SGTC_758 0868-0029 16 µM 0.0898938062891095 0.469794172457906 no 1825 0.464185801545645 499 762687
SGTC_73 0327-0325 16.231 µM 0.0897837331535448 0.469760521598273 no 1826 0.464229537520106 509 53298
SGTC_732 3970-1727 52.7 µM 0.0892143386018368 0.469586453367263 no 1827 0.464455785130562 515 1275699
SGTC_1184 1269-1718 139 µM 0.08896947315413 0.469511597928924 no 1828 0.464553085389178 498 5403821
SGTC_3341 9147222 25.867 µM 0.0879135996497469 0.469188829467357 no 1829 0.464972673750088 504 1939759
SGTC_2988 9073640 71.4286 µM 0.0868845994242729 0.46887429533942 no 1830 0.465381620551084 503 9102229
SGTC_2329 6138490 200 µM 0.0863375262569877 0.468707079578422 no 1831 0.465599054097652 487 720019
SGTC_2360 9040895 200 µM 0.0839729289320535 0.467984391966427 no 1832 0.466538977656188 477 4914414
SGTC_103 0844-0104 51.839 µM 0.0811446308347718 0.467120123088114 no 1833 0.46766346620769 497 5375804
SGTC_1765 st044815 90.4 µM 0.079876307828566 0.466732600138074 no 1834 0.468167816611261 516 645695
SGTC_1943 st076331 65.2 µM 0.0782705433071761 0.466242020711042 no 1835 0.468806424297433 526 24208415
SGTC_473 2-arachidonoylglycerol 10 µM 0.0761105185138324 0.465582189462504 no 1836 0.469665585926225 511 5282280 An endocannabinoid.
SGTC_2531 methyl deoxycholate 70.07 µM 0.0760780505425718 0.46557227206114 no 1837 0.469678501326259 515 16667744 Haematoxylin.
SGTC_617 3770-0098 35 µM 0.0755311109365247 0.465405211574192 no 1838 0.469896072639569 516 5962639
SGTC_917 harmaline 728.087 nM 0.0752015173506146 0.46530454149076 no 1839 0.470027188551944 494 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_2182 6325192 200 µM 0.0739575615157798 0.464924611383081 no 1840 0.470522076870954 521 736248
SGTC_2195 6536160 144.242 µM 0.0730386428812796 0.464643974943229 no 1841 0.470887683520601 506 3834386
SGTC_1427 4048-4900 550 nM 0.0726199145701502 0.464516101738855 no 1842 0.471054289512537 518 24132586
SGTC_2013 4024628 200 µM 0.0722248164840566 0.464395448203015 no 1843 0.471211498022651 503 5230760
SGTC_1781 st038725 66.3 µM 0.0721495501326018 0.464372464024637 no 1844 0.471241446819355 497 4270275 YIL048W NEO1
SGTC_2168 5727979 200 µM 0.0715881230422657 0.464201024099099 no 1845 0.471464846131281 518 695210
SGTC_2575 plumbagin 510 nM 0.0714863908936691 0.464169959418653 no 1846 0.471505327670238 520 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_23 0213-0011 39.996 µM 0.0689963965488284 0.463409689384971 no 1847 0.472496243901591 508 627608
SGTC_379 3970-0972 5.9 µM 0.0675947790812148 0.462981792085986 no 1848 0.473054105792487 515 2898042 YBL034C STU1
SGTC_1828 st055811 49 µM 0.0674609215753157 0.462940929199191 no 1849 0.473107385594279 526 5877589
SGTC_1199 1638-0010 4.46 µM 0.0673491504924537 0.462906808968314 no 1850 0.473151874623459 504 3111136
SGTC_3032 9089427 49.47 µM 0.0672417773474524 0.462874031547908 no 1851 0.473194613425942 524 17173707
SGTC_2015 5119600 184 µM 0.0661182491296137 0.462531071220769 no 1852 0.473641840968868 517 2828786
SGTC_221 trifluoperazine 10.304 µM 0.0633145553651111 0.461675357392507 no 1853 0.474758012756503 530 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_2047 4141938 200 µM 0.0615711278342808 0.461143336031424 no 1854 0.475452184977183 531 3807862
SGTC_1871 st057448 67.3 µM 0.0609831683284084 0.46096393094717 no 1855 0.475686306916067 516 691747
SGTC_2788 5282734 71.43 µM 0.0609236792934141 0.460945779398697 no 1856 0.475709995560997 506 743706
SGTC_1804 st050076 49.1 µM 0.0583906997221441 0.460172981826483 no 1857 0.476718711340375 524 3895976
SGTC_1779 st039427 55 µM 0.0583666028609717 0.460165630729726 no 1858 0.476728308229759 515 1124498
SGTC_1348 1493-0373 93.8 µM 0.0582397159057971 0.460126922249637 no 1859 0.476778842837849 524 3010129
SGTC_291 SEC14.278 35.5 µM 0.0580835260795163 0.460079275074804 no 1860 0.476841048260781 520 1068044
SGTC_810 3825-7150 143 µM 0.0579509042750927 0.46003881799661 no 1861 0.476893867735878 506 22330411 YGL099W LSG1
SGTC_1235 benzylparaben 21.5 µM 0.0575845002638948 0.459927046403519 no 1862 0.47703979809095 524 7180
SGTC_2366 9070441 60.58 µM 0.0572231036232715 0.459816805411578 no 1863 0.477183737140908 506 6837235
SGTC_785 1270-0111 65.3 µM 0.0544982376973047 0.458985708127336 no 1864 0.47826910630937 526 6741994
SGTC_433 pimozide 108 µM 0.0543226726707036 0.458932166052439 no 1865 0.478339043020958 508 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_1940 st075990 51.1 µM 0.0542056577513065 0.458896480420327 no 1866 0.478385656540095 524 1084979
SGTC_3331 9141060 1.957 µM 0.0538478028727954 0.45878734872194 no 1867 0.478528211777372 503 4906567 YPR165W RHO1
SGTC_549 1661-1316 519 µM 0.0532184410902653 0.458595425609501 no 1868 0.478778931285074 522 2857282
SGTC_1496 4469-0713 57.4 µM 0.0512400095660686 0.457992168378836 no 1869 0.479567135339323 527 746691
SGTC_2686 alizarin 95.37 µM 0.0498821549176752 0.457578191439436 no 1870 0.480108148955712 513 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_2480 5767542 37.17 µM 0.0494716119640269 0.457453035893318 no 1871 0.480271729930147 520 2867358
SGTC_3149 9097855 49.47 µM 0.0484888557432256 0.457153456166911 no 1872 0.480663322912196 538 25236625 YMR079W SEC14
SGTC_996 3970-0799 1.8 µM 0.0470790922545562 0.45672375169918 no 1873 0.481225095410618 512 6615648 YGL040C HEM2
SGTC_1926 methyl fluorone black 53.6 µM 0.0464268642023338 0.456524965719961 no 1874 0.481485012528479 525 72721 Reacts with homocysteine.
SGTC_771 0250-0039 27.3 µM 0.0463256320460424 0.456494113170921 no 1875 0.481525354909092 534 3005115
SGTC_364 0083-0097 67.7 µM 0.0453189480020367 0.456187320130825 no 1876 0.481926542316122 520 5207356
SGTC_1406 3909-7906 11.9 µM 0.044383006583933 0.455902109758623 no 1877 0.482299553540855 526 X1406
SGTC_307 1501-1223 22.3 µM 0.0439292416979235 0.455763841696758 no 1878 0.482480403144769 528 2830329
SGTC_1238 0333-0287 48.8 µM 0.0438440451017695 0.455737881782822 no 1879 0.48251435895328 525 7226
SGTC_225 nsc-122657 1.016 µM 0.0436691563586838 0.455684592725883 no 1880 0.482584062706424 531 275685
SGTC_3113 9123498 49.47 µM 0.0422774795964362 0.455260573672504 no 1881 0.483138748955057 528 8897275
SGTC_2299 7976368 114.88 µM 0.0419366904350634 0.455156749050965 no 1882 0.483274583688244 530 2979718
SGTC_3039 9090270 49.47 µM 0.0419277897545284 0.455154037415983 no 1883 0.483278131425646 534 17173750
SGTC_2281 7943571 200 µM 0.0413024088476587 0.454963517363857 no 1884 0.483527406363989 532 1244024
SGTC_749 1000-0129 128 µM 0.0377714596446232 0.453888021956983 no 1885 0.484934950015957 527 708470
SGTC_3231 9132313 49.47 µM 0.037131510612719 0.453693135187028 no 1886 0.485190073754951 526 4905967
SGTC_468 gf-109203x 121 µM 0.036427679748678 0.453478807051269 no 1887 0.485470671786986 539 2396 A protein kinase C inhibitor.
SGTC_1269 0831-0796 3.05 µM 0.0359571183183647 0.453335520868828 no 1888 0.485658275724851 530 927758
SGTC_736 0958-0254 92.6 µM 0.0354283027974932 0.453174503538096 no 1889 0.485869108252309 531 6812352
SGTC_9 0092-0002 10.449 µM 0.0350307437843848 0.453053457145478 no 1890 0.486027612958397 529 759368
SGTC_2684 capsaicin 100 µM 0.0340382499510456 0.452751287616346 no 1891 0.48642332465584 526 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_943 3253-1379 105 µM 0.0328201202539887 0.452380459576155 no 1892 0.486909016606257 533 668464
SGTC_515 4092-1064 102 µM 0.0310704245160669 0.451847882778099 no 1893 0.487606688047164 529 717353
SGTC_1667 st014849 34.6 µM 0.0302909658980308 0.45161065703907 no 1894 0.487917500718658 533 5348460
SGTC_16 erodoxin 22.806 µM 0.0298059152377273 0.451463042137197 no 1895 0.488110920593329 528 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_1056 3448-1962 115 µM 0.0295124446377811 0.451373733829006 no 1896 0.488227946939856 532 715507
SGTC_940 3232-1287 54.8 µM 0.0270683556877918 0.450630050242485 no 1897 0.48920260700552 533 1585493 YIL048W NEO1
SGTC_3133 9127736 49.47 µM 0.0264645150896582 0.45044634115947 no 1898 0.48944341826797 525 27243420
SGTC_3261 9137475 49.47 µM 0.0222963646691954 0.449178538067284 no 1899 0.491105774368233 543 17027690
SGTC_698 k064-0052 127 µM 0.021801720550066 0.449028119098756 no 1900 0.491303060856838 540 5088751
SGTC_1721 st082152 9.2685 µM 0.0212595824629764 0.448863265851454 no 1901 0.491519292533992 539 5296051
SGTC_2283 7944793 200 µM 0.0191996983314442 0.44823697740787 no 1902 0.492340899127895 537 2970533
SGTC_175 3793-3120 23.7 µM 0.0172127102759217 0.447632974539599 no 1903 0.493133461179015 543 5322297
SGTC_406 estrone 100 µM 0.0162365291338822 0.447336280249663 no 1904 0.49352284663257 540 5870 A steroid.
SGTC_1410 3909-8106 77.9 µM 0.0162191804783381 0.44733100767561 no 1905 0.49352976683352 544 1039210
SGTC_3190 9110366 49.47 µM 0.0144401173571213 0.446790367404506 no 1906 0.49423942684921 539 17123768
SGTC_2378 9074213 121.43 µM 0.0131835064532711 0.44640855489215 no 1907 0.494740694221088 540 657714
SGTC_3289 9119912 71.43 µM 0.0127761385638808 0.446284789628853 no 1908 0.494903196805268 540 17014829
SGTC_2704 st078022 71.1 µM 0.0113352691599065 0.445847071171527 no 1909 0.495477978710415 541 54697681
SGTC_1234 0326-0494 15.5 µM 0.0107368101156432 0.445665286018876 no 1910 0.495716714783924 542 1547813
SGTC_1587 estradiol valerate 56.1 µM 0.010635781197072 0.445634599067465 no 1911 0.495757017189798 545 13791 A steroid.
SGTC_1637 st007924 17.4 µM 0.0099970108787484 0.445440583813989 no 1912 0.496011836112612 544 683336
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.00900183769162672 0.445138343507205 no 1913 0.496408834844094 538 521171
SGTC_2284 7945075 39.21 µM 0.00667631673529573 0.444432192901912 no 1914 0.497336554763335 545 1245402
SGTC_2521 angolensin 13.4 µM 0.00582493970145848 0.444173713986735 no 1915 0.497676198413375 546 821428 A flavenoid.
SGTC_3148 9097893 49.47 µM 0.00345862796990107 0.443455424429554 no 1916 0.498620209821494 546 17174100
SGTC_304 1310-0298 97 µM 0.00311358552124411 0.443350702892558 no 1917 0.498757861098899 546 1550234
SGTC_158 k038-0087 26.446 µM 0.00227944291953646 0.443097554181422 no 1918 0.499090634631124 545 X158
SGTC_1853 st056710 91.2 µM 0.000947926423591883 0.442693508751513 no 1919 0.499621832127554 546 269167
SGTC_3085 9117376 49.47 µM 0.000690345858975816 0.442615353424324 no 1920 0.49972459187063 548 16480349
SGTC_1775 st081588 35.1725 µM -0.000606923528653872 0.442221768783014 no 1921 0.499757872558314 549 1426443 YGL099W LSG1
SGTC_2330 7979373 200 µM -0.0010382540696735 0.442090918001549 no 1922 0.499585796628225 548 1863007
SGTC_2696 st077691 74.316 µM -0.00299891775788702 0.441496200235703 no 1923 0.498803606704228 550 757133
SGTC_747 3448-8087 38.7 µM -0.00317405707068966 0.44144308254908 no 1924 0.498733736560286 551 5168703
SGTC_845 0330-0138 4.51 µM -0.00374365848393731 0.441270336450238 no 1925 0.498506499835937 550 9039800
SGTC_1169 aniline yellow 25.8 µM -0.00432992342388639 0.441092548381308 no 1926 0.498272615872881 550 6051 A DNA damaging agent.
SGTC_2059 5238311 157 µM -0.00449200517487495 0.441043398291578 no 1927 0.498207955238642 551 703021
SGTC_320 4092-0846 5.34 µM -0.00563783211765173 0.440695960707545 no 1928 0.497750842313439 552 1359356
SGTC_3226 9131256 49.47 µM -0.00572404540451206 0.440669820962489 no 1929 0.497716448743186 551 17178073
SGTC_774 k060-0086 136 µM -0.00587668637196255 0.440623541073979 no 1930 0.497655554831982 549 5911235
SGTC_709 3807-1509 243 µM -0.00627499231830299 0.440502780757304 no 1931 0.497496656683457 550 1886677 YPL242C IQG1
SGTC_53 0973-0023 39.979 µM -0.00681092372594263 0.440340303223511 no 1932 0.497282855564607 551 674768
SGTC_1908 st060353 56.5 µM -0.00711540765140206 0.440247997754111 no 1933 0.497161386998286 553 4227716
SGTC_2927 9011802 47.9 µM -0.00834823668996158 0.43987429414666 no 1934 0.496669574102214 555 43912568
SGTC_789 1309-1135 70.6 µM -0.00873866337291648 0.439755956480086 no 1935 0.496513822076291 552 3092424
SGTC_1307 1187-1599 12.2 µM -0.00965823130119637 0.439477258283956 no 1936 0.496146983082639 552 1538471
SGTC_3279 9140807 49.47 µM -0.0110579058425558 0.439053109316712 no 1937 0.495588623728739 552 45595718
SGTC_2039 Aminomethylbenzodioxan 200 µM -0.0110882861058696 0.43904390383826 no 1938 0.495576504500227 557 15053
SGTC_1755 st041960 45.185 µM -0.011569182380092 0.438898192567177 no 1939 0.495384666956432 553 2257073
SGTC_2805 7950783 58.44 µM -0.0122266804840006 0.438698984455347 no 1940 0.49512238173353 556 1178958 YDL195W SEC31
SGTC_1859 st055998 20 µM -0.0124521087129153 0.438630688010213 no 1941 0.495032455728367 562 676301
SGTC_2120 5538279 151.968 µM -0.0128023462319682 0.438524582575763 no 1942 0.494892742313426 556 2058197
SGTC_233 rapamycin 362 pM -0.0132893710799062 0.438377044383506 no 1943 0.49469846404514 554 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_2076 5212012 200 µM -0.0141361755545569 0.438120535776812 no 1944 0.494360669708003 554 604802
SGTC_1004 4084-0029 199 µM -0.014448790922488 0.438025846889132 no 1945 0.494235966958222 558 716894 YLR208W SEC13
SGTC_2583 asiatic acid 100 µM -0.0150156369028114 0.437854162478914 no 1946 0.494009852672264 554 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_2259 7964009 200 µM -0.01664443097553 0.437360903999592 no 1947 0.493360139333325 565 313134
SGTC_2421 5690543 90.72 µM -0.0170827434816213 0.437228183515101 no 1948 0.493185302805839 550 3397993
SGTC_214 4373-3496 70 µM -0.0184759469594957 0.436806370205015 no 1949 0.492629582918141 558 3779166
SGTC_753 1322-0200 289 µM -0.0195188790932075 0.436490653802983 no 1950 0.492213588286622 564 5403907
SGTC_1594 piperine 70.1 µM -0.0223239170547836 0.435641714015406 no 1951 0.491094785291901 560 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2746 daunorubicin 9.88 µM -0.0246473134644149 0.434938766510697 no 1952 0.49016814003035 561 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_684 1140-0066 328 µM -0.0259393868473758 0.434547936341945 no 1953 0.489652842222508 569 6813534
SGTC_1023 4482-3888 16 µM -0.0268996844243704 0.434257504106551 no 1954 0.48926987261015 561 3303168
SGTC_1420 4'-methoxyflavone 42 µM -0.0270284974423351 0.434218548614872 no 1955 0.489218502329143 562 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_1995 st072814 61.1 µM -0.0270748833881081 0.434204520784415 no 1956 0.48920000378396 561 5769371
SGTC_1433 4060-0023 7.6 µM -0.0271601313137498 0.434178740703708 no 1957 0.489166007284233 562 3840627
SGTC_938 3126-1755 342 µM -0.02752972861651 0.43406697291481 no 1958 0.489018614410737 553 1777771
SGTC_2308 7584454 197.62 µM -0.0279601032496791 0.433936832446648 no 1959 0.488846985845341 564 893577
SGTC_2376 9072922 81.32 µM -0.0299012507197898 0.433349940380952 no 1960 0.488072904183306 595 17087968
SGTC_1080 nisoldipine 24.4 µM -0.0314508477023081 0.432881536216429 no 1961 0.487454995291909 561 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_3337 9144342 33.5465 µM -0.0323778292123584 0.43260137806813 no 1962 0.487085371471116 561 17682949
SGTC_2832 7992762 51.95 µM -0.0326540198807006 0.432517912541818 no 1963 0.486975245569054 560 2985177
SGTC_1762 st045503 25.4615 µM -0.0336277240966261 0.432223680682471 no 1964 0.486587007067148 569 4645554
SGTC_2699 st077704 54.6 µM -0.0374701875674671 0.431062941625407 no 1965 0.485055055160915 574 645852
SGTC_1082 camptothecin 424.86 nM -0.0384589679144668 0.430764344761576 no 1966 0.484660873062031 564 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_655 k060-0012 42 µM -0.0397075958189637 0.430387334388538 no 1967 0.484163122933346 570 5994525
SGTC_1705 st027868 56.3335 µM -0.0401899577233918 0.430241707135932 no 1968 0.483970841869442 576 292948
SGTC_2638 epoxomicin 18 µM -0.0406841850882436 0.430092507487927 no 1969 0.483773834814043 571 9915668 A protesome inhibitor.
SGTC_1928 4'-methoxychalcone 40.3 µM -0.0409626318797828 0.43000845307421 no 1970 0.483662843141582 560 641818
SGTC_1799 st045822 46.1415 µM -0.042757638299269 0.42946667284033 no 1971 0.482947366412442 570 3674992
SGTC_1661 st013063 9.66 µM -0.0439564286194954 0.429104920243835 no 1972 0.482469567598904 576 721395
SGTC_1698 5-fluorocytosine 1.055 µM -0.0445982848597633 0.42891125514407 no 1973 0.482213754892451 566 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1349 flufenamic acid 69 µM -0.0454266574332319 0.428661338407302 no 1974 0.481883616678107 575 3371 A non-steroidal anti-inflammatory.
SGTC_713 1488-1073 324 µM -0.0460618735745291 0.428469715574522 no 1975 0.481630467107535 569 3312542
SGTC_2175 5807670 165.306 µM -0.0470289010662443 0.428178029075873 no 1976 0.481245096643326 568 241186
SGTC_1792 st045773 43.6 µM -0.0479511622616343 0.427899882079596 no 1977 0.480877582333756 580 2919270
SGTC_702 1488-0190 94 µM -0.0479521901338707 0.427899572101069 no 1978 0.480877172743232 557 949357
SGTC_952 1185-0122 232 µM -0.0480693512734012 0.427864239754893 no 1979 0.48083048604931 559 678600
SGTC_2563 tomatine 8.54 µM -0.048410385031976 0.427761397318995 no 1980 0.480694591475756 572 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_1046 2001-0062 216 µM -0.0489199668875039 0.427607736520063 no 1981 0.480491538318203 565 739778
SGTC_1766 st045414 44.774 µM -0.0500473628368061 0.427267817307941 no 1982 0.4800423227499 575 253960
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.0512317890727241 0.426910761152746 no 1983 0.479570410539968 578 165521
SGTC_3347 9188721 44.724 µM -0.0512979366198455 0.426890822130512 no 1984 0.479544056140261 575 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_1889 st059080 5.18 µM -0.0522493577250423 0.426604053554114 no 1985 0.479165002418554 597 176925 Isolated from Daphnopsis sellowiana.
SGTC_2456 5770359 74.46 µM -0.0526321563525537 0.426488684857527 no 1986 0.479012497702824 568 3118787
SGTC_2262 9014885 67.46 µM -0.0535458844197974 0.42621332891519 no 1987 0.478648486291178 578 6457424
SGTC_247 mechlorethamine 29.705 µM -0.0535604639768451 0.426208935593196 no 1988 0.478642678224018 570 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_2977 9011197 71.43 µM -0.0540335433488971 0.426066385479679 no 1989 0.478454219770149 571 2704722
SGTC_2853 9015042 58.44 µM -0.0542768520278586 0.425993074524279 no 1990 0.478357295883901 563 6457456
SGTC_2520 obtusaquinone 4.71 µM -0.0552751605218796 0.425692302565428 no 1991 0.477959625468284 564 5967872
SGTC_1085 doxorubicin 7.67 µM -0.0554036709282218 0.425653587884377 no 1992 0.477908435676912 567 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1388 3346-4487 254 µM -0.0565982441451648 0.425293748484535 no 1993 0.477432616636931 579 3345614
SGTC_2279 7948423 32.93 µM -0.0573723198399483 0.425060608092859 no 1994 0.477124306120169 570 1247112
SGTC_2929 9013348 24.6 µM -0.0586884778628219 0.424664260556146 no 1995 0.476600118426551 581 2995952
SGTC_1124 fisetin 1.16336 µM -0.0602766838955191 0.424186089969836 no 1996 0.475967635864554 611 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_1101 ebselen 5.29 µM -0.0609128471205474 0.423994587802573 no 1997 0.475714308961722 575 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_2474 5321570 43.32 µM -0.0616844282858034 0.423762345295463 no 1998 0.475407070390321 565 2841384
SGTC_396 dithiazanine 1.25 µM -0.0624185107591615 0.42354141430583 no 1999 0.475114777123753 574 10578 An antihelmenthic.
SGTC_345 1362-0200 395 µM -0.0637603304853914 0.423137639612952 no 2000 0.474580532820581 594 1419823
SGTC_3343 9148379 18.9835 µM -0.0657435626890855 0.422541001735755 no 2001 0.473790994701459 579 1955036
SGTC_351 caspofungin 25 nM -0.0659167193958431 0.422488917484914 no 2002 0.473722064689822 572 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_2453 5731132 22.18 µM -0.066175338870618 0.422411129192302 no 2003 0.473619115228913 591 1362040
SGTC_1892 st058411 7.36 µM -0.0677141918957147 0.421948331326817 no 2004 0.473006575871853 584 3934738
SGTC_3246 9135460 32.98 µM -0.0678370563850851 0.421911385441417 no 2005 0.472957672481123 573 41446951
SGTC_1718 roemerine 11.9335 µM -0.0688755321919423 0.421599138742212 no 2006 0.472544347369957 573 235224 An aporphine alkaloid with mutagenic activity.
SGTC_823 0417-1665 178 µM -0.0696211298996636 0.421374984394395 no 2007 0.472247609259442 597 3429856
SGTC_1850 st056238 17 µM -0.0712090180782241 0.420897691263456 no 2008 0.471615702125276 575 5393177
SGTC_2659 sanguinarine 24.21 µM -0.0721313706472502 0.420620500542983 no 2009 0.471248680537163 584 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_2642 cholecalciferol 100 µM -0.0730941044650074 0.420331216195049 no 2010 0.470865616533063 578 9821465 A vitamin D precursor, similar to steriods.
SGTC_762 1165-0429 115 µM -0.0742255355266126 0.419991296342052 no 2011 0.470415463739732 576 5967793
SGTC_43 0570-0105 72.5 µM -0.0763844049684736 0.419342865297648 no 2012 0.46955663819389 578 1114046 YDL195W SEC31
SGTC_781 4335-2806 94.4 µM -0.0765086024373621 0.419305568392217 no 2013 0.469507235140976 626 845254
SGTC_1119 parthenolide 318.541 nM -0.0774286214761649 0.419029306270981 no 2014 0.469141286238731 630 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_1392 3455-1037 33.9 µM -0.078061310352557 0.418839346434321 no 2015 0.468889641555547 580 981132
SGTC_592 k241-0073 46.5 µM -0.0809997805154675 0.417957342677404 no 2016 0.467721063527944 576 4230158
SGTC_3147 9097027 49.47 µM -0.0813263558504538 0.417859344040289 no 2017 0.467591207235315 587 25236841
SGTC_1407 3909-7909 12.3 µM -0.0815167794854338 0.417802204121683 no 2018 0.467515490593342 578 4411780
SGTC_295 k015-0027 31 µM -0.0836766183326492 0.417154228709448 no 2019 0.46665677390103 600 3887424
SGTC_1794 st048918 76.9 µM -0.0842895042300413 0.416970397096547 no 2020 0.466413128558292 581 672303
SGTC_3262 9137218 49.47 µM -0.0850928617708405 0.416729462102389 no 2021 0.466093782603476 579 17650664
SGTC_3297 9117502 71.43 µM -0.0857200743926808 0.416541376475029 no 2022 0.465844471903156 583 7453720
SGTC_67 0335-0847 266 µM -0.0866920167500263 0.416249952643413 no 2023 0.465458161118874 648 4552207 YOR254C SEC63
SGTC_764 1951-2361 146 µM -0.0876340927234983 0.41596752777823 no 2024 0.465083752167235 600 5438930
SGTC_361 000s-0510 1.45 µM -0.0876816578632794 0.415953269379075 no 2025 0.465064849185932 599 660
SGTC_1771 st048882 4.1505 µM -0.0884444558405543 0.415724623807265 no 2026 0.46476171453062 587 4580403
SGTC_459 nigericin 15.3 µM -0.0887488251263275 0.415633398317719 no 2027 0.46464076437779 622 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_1375 2910-0797 186 µM -0.0896476467254141 0.415364030279369 no 2028 0.464283610099035 580 742508
SGTC_1969 st069479 40.1 µM -0.0914038589892616 0.414837825537421 no 2029 0.463585847778734 591 3895485
SGTC_954 1189-0853 2.85 µM -0.0918080002973881 0.414716756367879 no 2030 0.463425293796124 592 2828194
SGTC_1760 st045453 10.4495 µM -0.0921743750220718 0.414607007985907 no 2031 0.463279748562907 588 3323419 YIL048W NEO1
SGTC_935 2996-0153 430 µM -0.0923934514746144 0.414541386320286 no 2032 0.463192721070644 589 23738523
SGTC_2282 7944268 200 µM -0.0924151677611028 0.414534881602795 no 2033 0.463184094434032 610 2970414
SGTC_20 0481-0013 4.944 µM -0.0938097524004316 0.414117208369348 no 2034 0.462630142278211 588 182045
SGTC_2176 5809774 33.9695 µM -0.0938819580386929 0.41409558567291 no 2035 0.462601462964696 603 2870539
SGTC_586 0957-0265 8.15 µM -0.0941778971912998 0.414006966472058 no 2036 0.462483921105666 593 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_1035 k081-0041 55.2 µM -0.0948851849257682 0.413795186376025 no 2037 0.462203012069403 586 731709
SGTC_2429 5902844 64.44 µM -0.0959947671125861 0.413462999535488 no 2038 0.461762364304779 587 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_1899 st063254 59.6 µM -0.0970130382705962 0.413158203889948 no 2039 0.461358020124164 586 3093813
SGTC_271 rotenone 740 µM -0.0982339216404247 0.412792830024465 no 2040 0.460873273571412 585 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_2373 9071805 200 µM -0.0982719973768167 0.412781436308786 no 2041 0.460858156693172 633 10149009
SGTC_1746 st038117 42 µM -0.0983928830503772 0.412745263181723 no 2042 0.460810162881258 582 2898218
SGTC_1700 st030840 7.9285 µM -0.0988621273392012 0.412604856268416 no 2043 0.460623869775675 588 5499307
SGTC_353 1988-1175 58.3 µM -0.101611527225955 0.411782408224875 no 2044 0.459532514704068 603 2788357
SGTC_918 glabranin 770.725 nM -0.102095267164528 0.411637743542998 no 2045 0.459340528820701 612 124049 Also referred to as licorice root.
SGTC_2238 6671620 73.2395 µM -0.102437704447422 0.411535343337846 no 2046 0.459204628623776 600 729941
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.103065016790318 0.411347771592328 no 2047 0.458955684840586 582 16725076
SGTC_3237 9133362 49.47 µM -0.105316412168466 0.410674752302864 no 2048 0.458062370185229 608 43845137
SGTC_1644 st010134 20.9 µM -0.108166683591558 0.409823085766923 no 2049 0.456931736251131 594 3818134
SGTC_556 4058-0063 51.5 µM -0.108520912854042 0.4097172710172 no 2050 0.45679124620925 610 6615692
SGTC_2074 5212007 75.395 µM -0.108575812577868 0.409700872055426 no 2051 0.456769473040703 589 758611
SGTC_3281 9140613 49.47 µM -0.108944589143531 0.409590719808359 no 2052 0.456623220037871 600 16013766
SGTC_3170 9103054 49.47 µM -0.11018874422381 0.409219147815319 no 2053 0.456129844361947 620 16432970
SGTC_504 lovastatin 124 µM -0.110376739081202 0.409163009467812 no 2054 0.456055299961133 639 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_509 pifithrin 175 µM -0.110823429538857 0.409029627845816 no 2055 0.455878182854087 586 4817 A p53 inhibitor.
SGTC_697 0508-1955 564 µM -0.113178255739943 0.408326651998491 no 2056 0.454944617147332 590 6243113
SGTC_971 1315-0384 26.7 µM -0.113658920748591 0.408183197369595 no 2057 0.454754088959933 627 6769120
SGTC_1103 duloxetine 36.1 µM -0.113725217229329 0.408163412128501 no 2058 0.454727810874502 606 60835 A selective serotonin reuptake inhibitor.
SGTC_336 4111-0029 111 µM -0.116876128706484 0.407223338325361 no 2059 0.453479107509633 623 3131175
SGTC_136 0097-0015 404.482 µM -0.116920866940254 0.40720999451563 no 2060 0.45346138106955 606 4861337
SGTC_1068 loratadine 26.9 µM -0.117609663543517 0.407004564807415 no 2061 0.453188473845768 612 3957 A H1 histamine antagonist.
SGTC_1831 st055328 12 µM -0.118336982730473 0.406787673724044 no 2062 0.452900327637054 600 1103068
SGTC_1365 1672-3266 55.4 µM -0.119117743620117 0.406554877810558 no 2063 0.4525910367265 597 6415873
SGTC_4 0960-0234 25.671 µM -0.119760910669728 0.406363132426289 no 2064 0.452336273889584 591 6821112
SGTC_2304 7443016 91.4 µM -0.120405294127895 0.406171046913999 no 2065 0.452081048903419 604 939854
SGTC_1202 1988-0068 29.6 µM -0.120768433498059 0.406062807942143 no 2066 0.451937226739161 597 2850480
SGTC_2607 solasodine 47.35 µM -0.121134395338773 0.405953734955374 no 2067 0.451792293110161 609 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_2155 5570423 76 µM -0.126345326772556 0.404401440334501 no 2068 0.449729289066928 618 797402
SGTC_2466 5983409 37.09 µM -0.127727163819639 0.403990053422336 no 2069 0.449182446269243 623 2879657
SGTC_739 1486-1183 203 µM -0.131381340386146 0.402902680693614 no 2070 0.447736824461389 628 4346692
SGTC_1590 st077108 57.8 µM -0.13219074643822 0.402661927106584 no 2071 0.447416710081526 595 5489485
SGTC_2274 7947094 46.08 µM -0.132311597361656 0.402625983797474 no 2072 0.447368917327994 602 2971028
SGTC_3303 9125618 40.5795 µM -0.135944119151309 0.401545989846094 no 2073 0.445932728582036 620 22695467
SGTC_682 0kpi-0099 17 µM -0.139611631896963 0.400456355080159 no 2074 0.444483424856491 622 1714895 YML126C ERG13
SGTC_2072 5231554 129 µM -0.141895348991208 0.399778242923048 no 2075 0.443581334056481 612 789545
SGTC_2150 5556613 200 µM -0.143326879762621 0.399353327381232 no 2076 0.443016014002266 606 743190
SGTC_2814 7977482 42.97 µM -0.144381463228806 0.39904037582089 no 2077 0.442599626817814 600 6456762
SGTC_1323 1348-1351 11.2 µM -0.145328032014347 0.398759533266302 no 2078 0.442225941658497 601 6989654
SGTC_807 1315-0151 48 µM -0.145947949990619 0.398575634879927 no 2079 0.441981239103469 649 4011080
SGTC_2677 mitomycin C 100 µM -0.146247218012432 0.398486865213946 no 2080 0.441863115829122 607 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_3006 9075424 71.4286 µM -0.146379546720531 0.398447615199696 no 2081 0.44181088636914 609 7465181
SGTC_2424 5537928 59.2 µM -0.147493151535417 0.398117349644054 no 2082 0.441371392448679 616 5382802
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.147818637042994 0.398020833075776 no 2083 0.441242950342403 596 17037758
SGTC_2331 7980721 200 µM -0.148631427815056 0.397779842611804 no 2084 0.440922236318993 627 2981221
SGTC_464 bw-b 70c 158 µM -0.148801970641674 0.397729282030443 no 2085 0.44085494780287 645 5353454
SGTC_2114 5491910 81.25 µM -0.148856115880343 0.397713230030278 no 2086 0.440833584888066 621 2849228
SGTC_2411 st077133 39.94 µM -0.15241860654302 0.396657469061643 no 2087 0.439428391315617 607 1403142 YNL221C POP1
SGTC_2323 6148992 148.28 µM -0.152730820981133 0.396564978810086 no 2088 0.439305277138436 618 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_80 0159-0065 512.242 µM -0.152761074838484 0.396556016731478 no 2089 0.439293347576731 610 1548079
SGTC_1499 4480-0877 67.3 µM -0.153437541232185 0.396355641854374 no 2090 0.439026620882036 590 2861909
SGTC_56 0957-0365 83.25 µM -0.155166338624778 0.395843682417563 no 2091 0.43834509236289 601 6752360
SGTC_2093 5331342 194.4 µM -0.15715646993715 0.395254555009832 no 2092 0.437560766939283 611 33839
SGTC_1485 3909-9022 254 µM -0.165375399610466 0.392824100469692 no 2093 0.434324257663303 621 714516
SGTC_2959 9079155 11 µM -0.166444896862133 0.392508139721421 no 2094 0.433903422049844 622 16189457
SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.166548428341412 0.392477557253585 no 2095 0.433862687500479 607 6708630 An antioxidant.
SGTC_77 0828-0286 12.516 µM -0.167763527993703 0.392118675070892 no 2096 0.433384658109868 627 745345
SGTC_1250 0485-0349 40.2 µM -0.167942779670117 0.392065740478111 no 2097 0.433314147375647 651 6842794 YDL195W SEC31
SGTC_1079 idarubicin 2.36 µM -0.168998971742033 0.391753878284358 no 2098 0.432898725098717 644 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_3224 9130643 49.47 µM -0.169793297020442 0.391519383394651 no 2099 0.432586349294404 642 17644395
SGTC_3068 9116768 49.47 µM -0.170112326389129 0.391425212971021 no 2100 0.432460899874715 625 41904888
SGTC_229 benomyl 22.8748 µM -0.171908193485313 0.390895231543672 no 2101 0.431754852507179 633 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_1148 3909-7663 27.7 µM -0.174569360039186 0.390110262860629 no 2102 0.430709012994371 673 4084526
SGTC_2910 7948405 25.97 µM -0.176087445788125 0.389662671010566 no 2103 0.430112621814549 613 2971328
SGTC_1142 3253-1408 9.78 µM -0.179428415833741 0.388678136670492 no 2104 0.428800660409689 618 256655
SGTC_2174 5790901 200 µM -0.180175168853601 0.388458177118791 no 2105 0.428507525893543 631 786020
SGTC_137 0438-0332 85.389 µM -0.180624899966156 0.388325723993003 no 2106 0.428331004999546 658 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.180680850586802 0.388309246533408 no 2107 0.428309045204939 643 16486 A toxic proline analog.
SGTC_2961 9083290 32.55 µM -0.18334069818394 0.387526153764269 no 2108 0.427265351513271 650 17741490
SGTC_2018 5133068 143 µM -0.18626789536715 0.38666487858848 no 2109 0.426117341316163 638 785362
SGTC_621 3584-0052 32.1 µM -0.186626947111509 0.386559272394654 no 2110 0.425976568599116 666 2273927
SGTC_2596 sinensetin 100 µM -0.18777895957417 0.38622049316434 no 2111 0.425524965091178 632 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_478 N-arachidonylglycine 10 µM -0.187807904367907 0.386211982310701 no 2112 0.425513619620198 618 5283389
SGTC_1988 st071872 53.4 µM -0.189711270343588 0.385652441775594 no 2113 0.424767694370098 621 16414116
SGTC_1258 0671-0043 57.1 µM -0.190111420335572 0.385534838214477 no 2114 0.42461091057459 672 4298767
SGTC_1967 st070177 51.4 µM -0.191119935050975 0.385238483758842 no 2115 0.424215814798617 653 5729214
SGTC_1534 6-azauridine 81.6 µM -0.191931964589204 0.384999915629205 no 2116 0.423897749385825 631 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_1437 4092-1038 11.6 µM -0.192200402289949 0.384921060233548 no 2117 0.423792615397652 633 3977136
SGTC_985 1493-0307 8.71 µM -0.192748860024439 0.384759961853008 no 2118 0.423577828055339 651 3278274
SGTC_2914 7968218 45.32 µM -0.193363844985888 0.384579346105284 no 2119 0.42333701428717 654 2977111
SGTC_2740 felodipine 17.08 µM -0.194245275382238 0.384320521335618 no 2120 0.422991916654542 629 3333 L-type calcium channel blocker
SGTC_2216 7189485 200 µM -0.194696330060925 0.384188092787053 no 2121 0.422815342560773 642 731273
SGTC_2141 5621638 7.665 µM -0.196845280889509 0.383557351965168 no 2122 0.421974307630833 655 2856238
SGTC_884 0851-0618 334 µM -0.198451901234789 0.3830859925343 no 2123 0.42134575675807 671 9642473
SGTC_1874 staurosporine 7.6 µM -0.198731994729631 0.38300383480426 no 2124 0.42123619750352 631 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_3092 9117248 49.47 µM -0.198960245936632 0.382936887476521 no 2125 0.421146920995744 625 17141857
SGTC_2840 9008771 71.43 µM -0.201445212930718 0.382208259732943 no 2126 0.420175232466676 602 2992978
SGTC_861 0443-0273 110 µM -0.201654025257199 0.382147051936319 no 2127 0.420093603332909 634 6149169
SGTC_1147 3809-1045 12.3 µM -0.202230314393643 0.381978143341464 no 2128 0.419868337622345 626 325925
SGTC_2683 piperine 63.03 µM -0.203194688798633 0.381695538394489 no 2129 0.419491431985259 651 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_333 3486-0131 40.1 µM -0.205647171602765 0.380977135303319 no 2130 0.418533263678442 627 6744690
SGTC_1070 indatraline 8.81 µM -0.206239503331496 0.380803685609955 no 2131 0.418301915936673 668 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_1808 st050063 61.5 µM -0.206405863924762 0.38075497533248 no 2132 0.418236945352139 660 4011993
SGTC_463 ikarugamyin 104 µM -0.207083816732803 0.38055649072813 no 2133 0.417972200268411 642 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_1093 fluphenazine 7.97 µM -0.208494743844646 0.380143513697616 no 2134 0.417421343135646 665 6602611 An atypical antipsychotic.
SGTC_1408 3909-7976 48.8 µM -0.208687444600593 0.380087120961346 no 2135 0.417346121052902 641 24152374
SGTC_2368 9071271 200 µM -0.208854279034957 0.380038299909947 no 2136 0.417280998512048 661 27209959
SGTC_2837 9008476 45.46 µM -0.210008322152819 0.379700642643005 no 2137 0.416830588867854 692 2992805
SGTC_606 k015-0008 38.6 µM -0.21147772047894 0.379270849495489 no 2138 0.416257257780149 664 1970475
SGTC_508 roscovitine 141 µM -0.212382506368614 0.379006277405152 no 2139 0.415904316189576 635 160355 A CDKinase inhibitor.
SGTC_1030 k029-0042 36.7 µM -0.212539185825881 0.37896046788673 no 2140 0.415843205078209 635 6080581
SGTC_42 0133-0086 60.653 µM -0.213478201851323 0.378685956553451 no 2141 0.415476994826949 664 162923 Model of phenazepam hydroxylation.
SGTC_1826 st055655 41.6 µM -0.214908079229904 0.378268064711441 no 2142 0.4149194928747 632 676168
SGTC_2891 9063876 19.48 µM -0.216083497304226 0.377924646995576 no 2143 0.414461331547105 622 6472478
SGTC_2459 5811157 9.22 µM -0.218231083941229 0.377297443514216 no 2144 0.41362453360381 633 2870684 YBR192W RIM2
SGTC_522 1273-0010 11.6 µM -0.218832766379285 0.377121779879401 no 2145 0.41339016077197 622 5705015
SGTC_1417 3966-0327 90.4 µM -0.219094060779393 0.377045501833213 no 2146 0.413288388598949 643 651118
SGTC_150 3970-0969 77.2 µM -0.220280127269207 0.376699321193155 no 2147 0.412826498102833 644 6615640
SGTC_451 chloral hydrate 100 µM -0.220744541938499 0.376563798136392 no 2148 0.412645673692756 679 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_909 3448-9333 149 µM -0.22105681279827 0.376472681441626 no 2149 0.412524098388393 647 3344074
SGTC_1507 4075-3230 155 µM -0.223008910764987 0.375903240076604 no 2150 0.411764285674693 623 659771
SGTC_776 4476-4378 112 µM -0.224547796067509 0.37545452623255 no 2151 0.411165540193804 665 2892008
SGTC_3166 9102297 49.47 µM -0.226928428301763 0.374760704733274 no 2152 0.41023969802962 655 25237072
SGTC_1993 st073995 70.8 µM -0.22738283522722 0.374628316446844 no 2153 0.410063033128126 641 3098394
SGTC_2079 5212404 121 µM -0.229377304701292 0.374047416634342 no 2154 0.409287837091624 658 758462
SGTC_1739 st037196 92.5 µM -0.229421748715356 0.374034475331202 no 2155 0.409270566939833 676 612214
SGTC_2298 7976326 193.81 µM -0.229635986333564 0.373972095154848 no 2156 0.409187320490362 651 2235818
SGTC_36 0335-0881 14.2 µM -0.232974279858421 0.37300050207855 no 2157 0.407890688986538 652 23828853
SGTC_897 1000-0139 31.4 µM -0.23623339147394 0.372052733033515 no 2158 0.406625785003719 671 6151020
SGTC_912 3474-0017 2.18 µM -0.244601567208141 0.369622778056206 no 2159 0.403382475230495 688 3360550
SGTC_1178 0988-0033 191 µM -0.24473889125491 0.369582944921433 no 2160 0.403329306356848 642 5392207
SGTC_491 tetrandrine 80.3 µM -0.245387334779327 0.369394871955809 no 2161 0.403078267333355 669 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_2443 5493264 126.67 µM -0.246677802597855 0.369020680862284 no 2162 0.402578793370249 673 5340055
SGTC_1200 1643-0193 18.4 µM -0.247412224604119 0.368807779235206 no 2163 0.402294607177921 678 5403974
SGTC_2560 caryophyllene 100 µM -0.248426942525612 0.368513688854539 no 2164 0.401902044854829 649 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_3134 9127454 49.47 µM -0.249297168437139 0.368261537164646 no 2165 0.401565460728352 655 24262820
SGTC_2127 5253358 187.912 µM -0.25009230509783 0.368031192505646 no 2166 0.401257983290587 664 20612
SGTC_740 k014-0057 261 µM -0.251193577144987 0.367712241272201 no 2167 0.400832225050075 682 4012779
SGTC_2025 5147754 141 µM -0.255979360873906 0.366327241016241 no 2168 0.398983387065307 666 315777 YLR208W SEC13
SGTC_1036 k216-0215 33.5 µM -0.256255487118726 0.366247383304878 no 2169 0.398876783008614 656 622330
SGTC_1367 1812-0510 76.9 µM -0.25799720024972 0.3657438008674 no 2170 0.398204533989299 656 1142582 YDR527W RBA50
SGTC_2087 5276107 200 µM -0.259660486663998 0.365263109841835 no 2171 0.397562837222678 643 144405
SGTC_1430 4049-0248 69.1 µM -0.259957781562917 0.365177213661537 no 2172 0.397448169836658 677 22774488
SGTC_2217 6934799 96.0675 µM -0.260886678623754 0.364908874891549 no 2173 0.397089949060117 670 675606
SGTC_411 enrofloxacin 100 µM -0.262166001636396 0.364539413770006 no 2174 0.396596731827749 676 71188 A bacterial gyrase inhibitor.
SGTC_113 0099-0221 2.5 µM -0.262330927765318 0.364491793200221 no 2175 0.396533159898604 643 89219
SGTC_3101 9120531 49.47 µM -0.264198839210425 0.363952600850663 no 2176 0.395813352738131 720 24824904
SGTC_1873 rapamycin 2 nM -0.26490569123068 0.36374863071981 no 2177 0.395541056976541 657 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_531 3788-1495 174 µM -0.265791215797264 0.363493157092066 no 2178 0.395200004370416 639 2896655
SGTC_1324 1418-0026 34.4 µM -0.266891927612969 0.363175686614904 no 2179 0.39477618605663 688 1372513
SGTC_2294 7971431 200 µM -0.268936941600547 0.362586107422441 no 2180 0.393989104288716 699 5741572
SGTC_191 3914-0123 66.505 µM -0.269745685578452 0.36235303566707 no 2181 0.393677955421763 691 3144412
SGTC_442 cape 100 µM -0.27141651491913 0.361871681358831 no 2182 0.393035350769496 674 5281787
SGTC_300 r073-0011 5.04 µM -0.271788223245589 0.36176462445264 no 2183 0.392892430486095 666 2735780
SGTC_2780 5215298 71.43 µM -0.272143307000942 0.361662365745245 no 2184 0.392755915763663 703 2834131
SGTC_2489 cantharidin 73.42 µM -0.27484406831841 0.360884911452995 no 2185 0.391718019864689 675 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1264 0783-0040 158 µM -0.275471321785607 0.360704429306162 no 2186 0.391477077853776 659 2855798
SGTC_828 2074-0507 139 µM -0.275739611930927 0.360627242579898 no 2187 0.391374034346063 662 X828
SGTC_529 4076-0302 30.3 µM -0.276448517026757 0.360423318834712 no 2188 0.391101798399078 670 5816522
SGTC_2028 5153890 36.43 µM -0.279882045701475 0.359436192147105 no 2189 0.389784001202415 692 2830968 YPR165W RHO1
SGTC_1648 st011736 69.8 µM -0.281488544369729 0.358974651236037 no 2190 0.389167856649461 664 2855514
SGTC_958 1222-0007 33 µM -0.284403834502874 0.358137625506029 no 2191 0.388050460386187 703 7312461
SGTC_1182 1222-0449 220 µM -0.284934602049231 0.357985306984101 no 2192 0.38784712285089 661 658318
SGTC_3160 9100216 49.47 µM -0.28567347683595 0.357773303938284 no 2193 0.387564110449195 671 17191039
SGTC_543 3844-1095 191 µM -0.286456988727655 0.357548541228223 no 2194 0.387264065881095 685 4230703
SGTC_2449 5812982 45.77 µM -0.288732202574146 0.356896140586962 no 2195 0.386393158818984 668 776185
SGTC_1526 st051518 75 µM -0.294961166467456 0.355112176654014 no 2196 0.38401177262185 671 673993
SGTC_615 k087-0205 167 µM -0.295682177200053 0.354905884538488 no 2197 0.383736404720966 662 9642773
SGTC_977 1348-1378 135 µM -0.297198710735811 0.354472120146018 no 2198 0.383157403056796 663 X977
SGTC_934 2950-0684 338 µM -0.301906763459321 0.3531267102035 no 2199 0.381361569855951 710 1121253
SGTC_2277 7947813 106.88 µM -0.302862480513956 0.352853820407061 no 2200 0.38099733272882 709 1246798
SGTC_315 k915-0449 187 µM -0.305447072297863 0.352116210779385 no 2201 0.380012837543659 680 20970215 YNL149C PGA2
SGTC_18 0111-0177 500 nM -0.306192235119143 0.351903653928659 no 2202 0.379729142077073 705 721752
SGTC_2487 5918373 44.05 µM -0.306654050569426 0.35177194481622 no 2203 0.379553353986193 681 2876279
SGTC_1977 st070720 65.3 µM -0.306808015418858 0.35172803821207 no 2204 0.379494753451059 680 682188
SGTC_170 4197-0004 226 µM -0.308106155354528 0.35135792254888 no 2205 0.379000778814103 672 218692
SGTC_575 k072-0246 11.9 µM -0.309913096122901 0.35084297613431 no 2206 0.378313521767441 674 6796779
SGTC_1686 st019653 115.5 µM -0.312441012643213 0.350123023999642 no 2207 0.377352692838611 710 97252
SGTC_3093 9117344 49.47 µM -0.312701306691447 0.350048922626012 no 2208 0.377253801362691 666 24824913
SGTC_1783 st039459 87.517 µM -0.313577958477537 0.349799396496464 no 2209 0.376920801164389 742 729761
SGTC_1291 0993-0025 5.79 µM -0.315141716344522 0.349354456751971 no 2210 0.376327027972921 686 4353356
SGTC_1950 st077106 7.18 µM -0.317529094203488 0.348675569735658 no 2211 0.375421083404638 661 13831864
SGTC_930 2810-3379 265 µM -0.323476504528558 0.346986443541829 no 2212 0.373167199275561 736 1015764
SGTC_1050 3232-1156 69.3 µM -0.324369372017451 0.346733121211444 no 2213 0.372829202423077 697 700529
SGTC_2585 alliin 100 µM -0.324756663219236 0.34662326112983 no 2214 0.372682622950768 731 87310 A garlic compound which reacts with lipids.
SGTC_821 1114-0266 29.2 µM -0.325519313346711 0.346406963421235 no 2215 0.372394033969114 693 3123235
SGTC_1327 1436-0082 2.18 µM -0.325558556668358 0.346395834847934 no 2216 0.372379186120976 693 15992205
SGTC_2974 9094440 9.66 µM -0.326879328752042 0.346021369293672 no 2217 0.371879578136919 678 25236134
SGTC_2508 celastrol 40.54 µM -0.327243826863415 0.345918053207103 no 2218 0.371741737502604 661 122724 Celastrol is a natural product and antioxidant.
SGTC_2511 berberine 10.47 µM -0.327896527129822 0.345733075598915 no 2219 0.371494949826923 684 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1774 st048371 48.465 µM -0.328410823872677 0.345587347982836 no 2220 0.371300530081264 681 4242727
SGTC_964 1287-0107 19.4 µM -0.32964151412405 0.345238720908839 no 2221 0.370835425274296 693 51516812 YPR165W RHO1
SGTC_2798 7813637 45.45 µM -0.329811352026969 0.345190619924882 no 2222 0.370771254609264 716 956368
SGTC_1879 gemcitabine 100 µM -0.330197404079792 0.345081292718687 no 2223 0.370625404094058 681 60750 A nucleoside analog which inhibits DNA replication.
SGTC_2864 9034755 47.6 µM -0.331079293760917 0.344831596325128 no 2224 0.370292295831764 675 4930451
SGTC_2893 9048488 25.97 µM -0.331786006377845 0.344631547961093 no 2225 0.370025425805104 676 6467338
SGTC_15 0266-0086 27.098 µM -0.332857969476828 0.344328191478502 no 2226 0.369620748735185 700 1712902 YIL048W NEO1
SGTC_2372 9071633 200 µM -0.334354877231555 0.343904746810886 no 2227 0.369055892344306 698 21321366
SGTC_1144 3486-0183 12.5 µM -0.334624862209986 0.343828394385682 no 2228 0.368954043881521 738 6744069
SGTC_1936 st074407 74.3 µM -0.335063697661862 0.34370430421588 no 2229 0.368788518320244 677 809813
SGTC_1763 st044482 94.5 µM -0.335193622904552 0.343667568286978 no 2230 0.368739516125612 701 88505
SGTC_2807 7945238 51.95 µM -0.341082105064736 0.342004174009487 no 2231 0.366520886218535 727 17148797
SGTC_1916 st067606 49.2 µM -0.341267878183645 0.341951745976387 no 2232 0.36645096372339 673 19590279
SGTC_1268 0828-0275 2.46 µM -0.341545128215628 0.341873507418679 no 2233 0.366346618797618 702 745337
SGTC_2956 9076196 2.52 µM -0.341926850045375 0.341765798558977 no 2234 0.366202971371539 715 16423868
SGTC_2071 5230951 39.92 µM -0.341933011861366 0.34176406001062 no 2235 0.366200652745082 678 1799272
SGTC_782 0083-0095 30.5 µM -0.347300102020838 0.340251020670951 no 2236 0.364182937074524 719 3591729 An indicator and reagent.
SGTC_2879 9041815 71.43 µM -0.349040607563384 0.33976090411257 no 2237 0.363529411968837 700 4942971
SGTC_2177 5811945 192 µM -0.349362488331717 0.339670293945724 no 2238 0.36340859559821 698 5343475
SGTC_116 0155-0182 31.788 µM -0.3503872449722 0.339381884348006 no 2239 0.363024048737202 710 771486
SGTC_390 dec-rvkr-cmk 16.7 µM -0.353578735928495 0.33848426788315 no 2240 0.361827306246873 691 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_1944 st076371 56.9 µM -0.355067516687168 0.338065857091498 no 2241 0.361269505547883 688 24208455
SGTC_2382 9035899 200 µM -0.355696501078452 0.337889145745713 no 2242 0.361033932815648 734 6462679
SGTC_521 r062-0005 13.8 µM -0.356340274701044 0.337708316399703 no 2243 0.360792875663299 692 2832033
SGTC_1898 st060199 18.6 µM -0.356353198915663 0.337704686505033 no 2244 0.360788036834913 674 688866
SGTC_868 0527-0199 213 µM -0.35657666865673 0.337641925185399 no 2245 0.36070437324644 718 2849450
SGTC_2136 5328288 199.296 µM -0.357978679727638 0.337248274445799 no 2246 0.36017963440645 698 262395
SGTC_341 1486-1430 230 µM -0.358826383297962 0.337010346193305 no 2247 0.35986248712863 709 2054753 YPL210C SRP72
SGTC_567 1080-0542 68.4 µM -0.359096198607931 0.336934629755774 no 2248 0.359761562645264 679 5950415
SGTC_2134 5324836 1.464 µM -0.360189700301683 0.336627835481297 no 2249 0.35935263824975 704 699272
SGTC_2771 fluoxetine 41.05 µM -0.361620186122373 0.336226660633125 no 2250 0.358817938911723 721 3386 A selective serotonin reuptake inhibitor.
SGTC_1738 st035555 74 µM -0.362206405892728 0.336062311135006 no 2251 0.358598896451911 743 5331140
SGTC_404 fumagillin 50 µM -0.36270110938102 0.335923643038986 no 2252 0.35841408545505 707 12015870 A methionine aminopeptidase binder.
SGTC_2849 9019321 12.99 µM -0.363708057409756 0.335641458998424 no 2253 0.358038012961494 672 16489627
SGTC_860 0443-0016 25.1 µM -0.364084614094055 0.3355359576998 no 2254 0.35789741284866 709 5337942
SGTC_1039 k821-0043 94 µM -0.364246917607946 0.335490488513533 no 2255 0.357836817311981 724 15992768
SGTC_2895 9054447 58.44 µM -0.364330668841074 0.33546702662175 no 2256 0.357805550437975 699 2697450
SGTC_2099 5377090 177.372 µM -0.367509977163655 0.334576857155386 no 2257 0.356619325521917 723 2243829
SGTC_492 tmb-8 126 µM -0.369201105456729 0.334103739029351 no 2258 0.355988915979455 701 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.369460667504408 0.334031146018373 no 2259 0.355892192653684 712 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1934 st074720 32.6 µM -0.370255279377859 0.33380895156734 no 2260 0.355596145788601 687 17250992
SGTC_2912 7964298 10.93 µM -0.370909641459635 0.333626018399171 no 2261 0.355352416871661 701 2975850
SGTC_2782 7736369 71.43 µM -0.372966378457661 0.333051295600592 no 2262 0.354586733755471 706 2950836 YOL077C BRX1
SGTC_1486 3970-0793 4.53 µM -0.37376248403686 0.332828941549455 no 2263 0.35429051661767 724 2844330
SGTC_488 nitrendipine 139 µM -0.374797067963653 0.332540067803233 no 2264 0.353905697509541 704 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_535 2293-4129 48.2 µM -0.377021689992599 0.331919251716377 no 2265 0.353078743018395 747 396118 YIL048W NEO1
SGTC_2108 5365811 200 µM -0.377068634436906 0.331906156086979 no 2266 0.353061299907038 687 780283
SGTC_978 1416-0512 87.4 µM -0.377955781889076 0.331658715922285 no 2267 0.35273172129329 729 6814003
SGTC_3295 9122362 53.5725 µM -0.379195504173041 0.331313059805076 no 2268 0.352271344936381 733 4730473
SGTC_2208 7283366 200 µM -0.379439282923449 0.331245106945958 no 2269 0.352180842056195 702 898663
SGTC_1778 st046819 58.9 µM -0.379752162026574 0.331157900638569 no 2270 0.352064697931871 711 671715
SGTC_81 0411-0046 9.971 µM -0.380377253678651 0.330983701233647 no 2271 0.351832698448666 721 12925265
SGTC_633 0437-0093 97.7 µM -0.380902960376136 0.330837226566392 no 2272 0.351637627865255 714 2831118
SGTC_1924 st058459 75.1 µM -0.381586711637213 0.330646755585302 no 2273 0.351383971150611 706 688683
SGTC_372 0155-0182 15.9 µM -0.384574824915556 0.329814878958988 no 2274 0.350276224519947 711 771486
SGTC_227 fluconazole 33.516 µM -0.385097435179245 0.329669473029111 no 2275 0.350082614094051 721 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_1360 1598-0022 39.8 µM -0.385738172511472 0.329491235717061 no 2276 0.349845294529793 739 761525
SGTC_1867 st057372 64 µM -0.386590275627828 0.329254261666585 no 2277 0.34952977910046 706 688837
SGTC_2485 5633444 17.78 µM -0.386779940806159 0.329201524179489 no 2278 0.349459564303103 696 5724239
SGTC_1494 4358-1428 177 µM -0.386861320928483 0.329178897013132 no 2279 0.349429438639736 736 1564571
SGTC_1607 st000305 50.6 µM -0.387740906612827 0.328934374392689 no 2280 0.349103890174146 738 5457690
SGTC_1628 st004252 77.7 µM -0.388949363075555 0.328598545889666 no 2281 0.348656802543612 675 692968
SGTC_3036 9090181 49.47 µM -0.391457864808019 0.327901878507669 no 2282 0.347729413879187 694 25236586
SGTC_2715 st079500 56.4 µM -0.394014060554645 0.327192580971761 no 2283 0.346785329200527 722 28246688
SGTC_1339 1486-1321 22.7 µM -0.396443423975777 0.326519054933597 no 2284 0.345888968485813 720 3469382
SGTC_3173 9105693 49.47 µM -0.396916571833109 0.326387943290031 no 2285 0.345714491668107 766 17096658
SGTC_976 1348-1067 47.6 µM -0.397761062305234 0.326153984057599 no 2286 0.345403160925569 708 5310671 YGL099W LSG1
SGTC_511 blebbistatin 171 µM -0.398205666894206 0.326030837445349 no 2287 0.345239294535076 726 3476986 A myosin inhibitor.
SGTC_794 k038-0031 316 µM -0.398282824079525 0.326009468373899 no 2288 0.345210859928751 710 6624242
SGTC_778 3456-2434 196 µM -0.398291022961678 0.326007197685738 no 2289 0.345207838460007 717 5539063
SGTC_194 1486-1323 56.904 µM -0.39883296303837 0.325857121181218 no 2290 0.345008143488257 710 5178754
SGTC_2355 9061122 103.12 µM -0.399088188261087 0.325786452824939 no 2291 0.344914112623605 730 5302957
SGTC_2702 st077768 96.8 µM -0.401214359361793 0.325197988733974 no 2292 0.344131154804707 696 6484119
SGTC_3048 9093155 49.47 µM -0.40155295771599 0.325104314454703 no 2293 0.344006528256492 709 25236002
SGTC_1748 st037455 53.6035 µM -0.403658956595469 0.324521931734514 no 2294 0.34323176253081 749 580690
SGTC_2022 5136654 200 µM -0.404497661930527 0.324290119548329 no 2295 0.342923398427822 754 1713771
SGTC_2987 9018338 71.43 µM -0.40605791967648 0.323859056610687 no 2296 0.342350021883374 728 5055682
SGTC_220 paclitaxel 373.376 µM -0.408641125072685 0.323145896326182 no 2297 0.34140152289141 727 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2220 6782180 200 µM -0.409674335362942 0.322860833755919 no 2298 0.341022429562029 720 833803
SGTC_432 NS 1619 61.3 µM -0.410435460035475 0.322650906109578 no 2299 0.340743269278767 709 4552 A K+/calcium channel activator.
SGTC_1393 3470-5649 58.2 µM -0.410712849571207 0.322574412675817 no 2300 0.340641551848204 737 4108395
SGTC_216 k038-0035 28.382 µM -0.412263301950432 0.322146995520592 no 2301 0.34007322187417 710 4444231 YPR107C YTH1
SGTC_443 clozapine 122 µM -0.413271893123923 0.321869080792082 no 2302 0.339703710085155 746 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_1835 st008666 49.2 µM -0.413504898630917 0.321804890877235 no 2303 0.339618367073223 716 690455
SGTC_1811 st050069 61.5 µM -0.41409562018312 0.32164217878885 no 2304 0.339402040130524 729 3877702
SGTC_2551 apiole 73.87 µM -0.41665288266233 0.320938185095917 no 2305 0.338466161333053 703 10659 A possible DNA adduct former.
SGTC_1262 0737-0114 49.6 µM -0.418732431347981 0.320366176219024 no 2306 0.337705845504163 758 765919
SGTC_1040 k898-0338 155 µM -0.418835124404331 0.320337940101647 no 2307 0.337668316426241 743 20969351
SGTC_2920 7982904 15.77 µM -0.420214386950864 0.319958803832124 no 2308 0.3371644228236 739 6456808
SGTC_79 0052-0007 94.094 µM -0.420702069898265 0.319824792885383 no 2309 0.336986324746326 728 2801472
SGTC_234 nsc-17383 10.7 µM -0.424321649415622 0.318830900417959 no 2310 0.335665626268858 728 408974
SGTC_1176 0848-0131 83.3 µM -0.425741610469024 0.318441351440081 no 2311 0.335148069002952 740 6769040
SGTC_2687 chenodiol 100 µM -0.428464736340366 0.317694856704226 no 2312 0.334156401006108 704 5702181 A cholesterol synthesis inhibitor.
SGTC_2398 5228213 48.84 µM -0.430929197325559 0.317019908332683 no 2313 0.333259926447467 738 80771 YMR134W ERG29
SGTC_3027 9089541 49.47 µM -0.43150119452242 0.316863340870637 no 2314 0.333051992124708 726 9943819
SGTC_1025 k007-0731 70 µM -0.432387539137224 0.316620794801675 no 2315 0.332729886569545 712 6256118
SGTC_1878 temozolomide 1 mM -0.435165565046447 0.315861105787408 no 2316 0.331721127705186 747 5394 DNA alkylating agent.
SGTC_3177 9107506 49.47 µM -0.435416218391107 0.315792599392734 no 2317 0.331630170122635 743 8897194
SGTC_2764 methyldopa 94.69 µM -0.438699623293569 0.314895792728892 no 2318 0.330439600038985 763 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_2319 6033012 152.6 µM -0.439140315201555 0.314775508048134 no 2319 0.330279934363564 716 847246
SGTC_377 3970-0964 33.1 µM -0.440702300342667 0.314349330228876 no 2320 0.329714265520575 736 16481235
SGTC_2189 6047310 154.431 µM -0.441928628690763 0.314014907534669 no 2321 0.329270426625348 730 711535
SGTC_510 ag-490 170 µM -0.442916104235411 0.313745731526471 no 2322 0.328913209285904 742 5328779
SGTC_1674 st016616 23.6 µM -0.444206073564438 0.313394248039252 no 2323 0.328446800761248 708 625830
SGTC_1059 3448-6867 171 µM -0.449097003778105 0.312063136170131 no 2324 0.326680840881874 733 3934407
SGTC_3022 9087993 49.47 µM -0.450019814003294 0.311812259079473 no 2325 0.326348076837345 736 17173644
SGTC_542 3381-0244 89.3 µM -0.450643297693286 0.311642806925715 no 2326 0.326123327706807 761 1112843
SGTC_2404 5161160 200 µM -0.450898145392783 0.311573555179606 no 2327 0.326031480127837 748 2831543
SGTC_3129 9127257 49.47 µM -0.451265785056282 0.311473665338842 no 2328 0.325899000712711 769 837894
SGTC_2354 9060492 162 µM -0.452271574574948 0.311200457384881 no 2329 0.325536675543542 752 6471895
SGTC_284 0988-0104 32.6 µM -0.45431601553322 0.310645435626657 no 2330 0.324800695239783 750 4666532
SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.458355564964366 0.30955005187774 no 2331 0.323348505023829 768 61125 An anti-inflammatory.
SGTC_2051 5263410 176 µM -0.458694665569621 0.309458176460533 no 2332 0.323226722646881 755 227584
SGTC_3186 9110464 49.47 µM -0.460141892171149 0.309066200941969 no 2333 0.322707188189789 736 17018021
SGTC_1459 k035-0031 35.7 µM -0.46054557575747 0.308956903600586 no 2334 0.322562332985315 735 3877128 YMR208W ERG12
SGTC_2158 5657123 3.6195 µM -0.462579056636458 0.3084065959303 no 2335 0.321833061720884 787 2858827
SGTC_184 1494-0393 24.714 µM -0.463080131270267 0.308271059387329 no 2336 0.321653465538088 750 3090647
SGTC_847 0342-0274 5.54 µM -0.464876821748122 0.307785284437039 no 2337 0.321009834927149 737 18097
SGTC_3095 9117207 49.47 µM -0.466210890610217 0.307424807232914 no 2338 0.320532277359296 738 17015229
SGTC_2179 6298986 200 µM -0.466712039541673 0.307289440381409 no 2339 0.32035295741033 750 738374
SGTC_1964 st076914 61 µM -0.467192007373273 0.307159819429944 no 2340 0.320181255748362 764 24208661
SGTC_93 0109-0045 59.227 µM -0.467846077828364 0.306983218806683 no 2341 0.319947333333393 746 88733
SGTC_2035 5154463 94.595 µM -0.468095063831904 0.306916003740406 no 2342 0.319858304532635 768 2769623
SGTC_880 0833-0487 87.2 µM -0.469578501787479 0.30651567653002 no 2343 0.319328093529387 737 76075
SGTC_1156 4092-0367 4.88 µM -0.471183727175642 0.306082743178084 no 2344 0.318754769162869 764 1357585
SGTC_3259 9138485 49.47 µM -0.471548621449267 0.305984368010502 no 2345 0.318624503480212 731 17646153
SGTC_2156 5649887 115 µM -0.471746849792798 0.305930931692855 no 2346 0.318553746210127 736 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_2440 5628896 157.78 µM -0.474610214656052 0.305159517038292 no 2347 0.317532412125444 768 5522048
SGTC_2502 avocadyne acetate 18.59 µM -0.475214714447186 0.304996770134576 no 2348 0.317316970098889 719 3952079
SGTC_160 3453-0671 289.699 µM -0.476375183944739 0.304684449966145 no 2349 0.316903555505287 783 5322268
SGTC_2347 9049783 174.81 µM -0.476883195489085 0.30454777226968 no 2350 0.316722649436669 791 6467988 YPL169C MEX67
SGTC_693 4161-2696 114 µM -0.476968609801454 0.304524794700267 no 2351 0.316692237171482 752 805759
SGTC_1829 berberine 14.4 µM -0.47817790710701 0.304199560682961 no 2352 0.316261792823793 758 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_905 2-aminofluorene 215 µM -0.47965430347665 0.303802701729578 no 2353 0.315736613070573 733 1539 An established DNA mutagen. YPR165W RHO1
SGTC_198 3454-2873 16.191 µM -0.481670673152892 0.303261070132232 no 2354 0.31501995624097 756 710957
SGTC_765 1319-0117 244 µM -0.481902444556068 0.303198840015715 no 2355 0.314937624733132 723 3487746 YGL099W LSG1
SGTC_2618 avocadyne 43.43 µM -0.482917412948742 0.302926390495634 no 2356 0.314577188695217 765 3015189
SGTC_2492 derrusnin 100 µM -0.483912522408757 0.302659378178499 no 2357 0.314223976441743 777 1715307 Part of coumarin class of compounds.
SGTC_1216 1165-0504 9.65 µM -0.487626343800339 0.301663801186969 no 2358 0.312907266143183 759 6304004
SGTC_2523 spermine 47.74 µM -0.488430607099915 0.301448393683537 no 2359 0.312622433368535 736 1103 A DNA binding polyamine.
SGTC_3223 9129970 49.47 µM -0.488986534924404 0.301299538860292 no 2360 0.312425614885699 736 17248386
SGTC_541 4513-1321 94 µM -0.489257687454762 0.30122694727072 no 2361 0.312329636525657 749 747515
SGTC_1231 0242-0792 125 µM -0.49024257106422 0.300963345490419 no 2362 0.311981129875335 772 3707635
SGTC_1019 4262-0212 3.4 µM -0.49074818548338 0.300828059395926 no 2363 0.311802280680823 764 4677213
SGTC_1683 st010134 710 nM -0.492812117347919 0.300276102633931 no 2364 0.311072674005321 782 3818134
SGTC_2765 myclobutanil 7.74 µM -0.493458961448193 0.300103211545438 no 2365 0.310844165043197 796 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_2241 6772625 37.8075 µM -0.494569043711718 0.29980660928792 no 2366 0.310452179126068 758 2285411
SGTC_426 0988-0037 14.6 µM -0.497349536972966 0.299064274110695 no 2367 0.309471292347981 773 5383008
SGTC_670 4204-0025 119 µM -0.497760390546806 0.298954655360379 no 2368 0.309326468541837 753 719039
SGTC_1724 st037281 8.293 µM -0.498717502208243 0.298699361744556 no 2369 0.308989206406542 735 574124 YDL195W SEC31
SGTC_1207 2099-0101 141 µM -0.499036953892769 0.298614175387052 no 2370 0.308876675460527 770 5837381
SGTC_1384 3089-0840 101 µM -0.500040802482438 0.298346556748782 no 2371 0.308523173733211 748 1069836
SGTC_2019 4016004 108 µM -0.502155917545171 0.297783040326999 no 2372 0.307778924449715 760 45595336
SGTC_1213 1315-0166 115 µM -0.502722875703782 0.297632071883032 no 2373 0.307579562046572 729 768401
SGTC_2769 toremifene 3.73 µM -0.502825596725293 0.29760472328024 no 2374 0.307543447805226 739 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_686 1319-0111 510 µM -0.504297189762673 0.297213050070353 no 2375 0.307026275988726 808 4562600
SGTC_1884 5633444 25 µM -0.506654869359424 0.296586031287839 no 2376 0.306198500905593 748 5724239
SGTC_2525 harmine 47.85 µM -0.507539395670758 0.296350950222302 no 2377 0.305888200787522 747 5280953 A monoamine oxidase inhibitor
SGTC_1255 0566-0045 221 µM -0.507603476357495 0.296333922780619 no 2378 0.30586572609038 762 2788469
SGTC_2581 avocatin a 64 µM -0.508097491415833 0.296202668765787 no 2379 0.305692487219018 790 6710728 A skin care supplement.
SGTC_2001 4023502 57.655 µM -0.508671855533415 0.296050100483452 no 2380 0.305491126581903 753 108941 YCR052W RSC6
SGTC_2817 7995342 71.43 µM -0.511105309713626 0.295404102791416 no 2381 0.30463865906832 792 18879975
SGTC_64 000l-0018 272.079 µM -0.511268695105042 0.295360752876928 no 2382 0.304581461169439 774 6811119
SGTC_2300 7976697 71.57 µM -0.51136963784297 0.295333971902158 no 2383 0.304546125559827 742 2236109
SGTC_1276 0871-0068 94.2 µM -0.512890869858802 0.294930511368038 no 2384 0.304013830201839 766 3414906
SGTC_1064 honokiol 6.76 µM -0.513162658450019 0.294858454460127 no 2385 0.303918772151606 768 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_2448 5185112 27.17 µM -0.513579870529354 0.29474785849932 no 2386 0.303772878037914 740 5718189
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.513879376619042 0.294668476228801 no 2387 0.30366816358483 743 115019
SGTC_723 4182-0001 115 µM -0.515082571260985 0.29434967621716 no 2388 0.303247660596423 767 744821 YLR208W SEC13
SGTC_813 k007-0158 173 µM -0.516259354672056 0.294038028307072 no 2389 0.302836640041198 775 6523916
SGTC_2522 biochanin a 4.94 µM -0.516530172572339 0.293966329116135 no 2390 0.302742085546766 773 5280373 A possible chelator.
SGTC_2932 9016711 44.54 µM -0.518666917707415 0.293400908372163 no 2391 0.3019965176647 784 7117328
SGTC_259 usnic acid 108.925 µM -0.51879605901971 0.293366751438025 no 2392 0.301951483224414 810 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_3033 9090887 49.47 µM -0.525757934565644 0.291528119579931 no 2393 0.299528202531031 761 19325384
SGTC_2713 st079149 53.4 µM -0.526810025977169 0.291250730250139 no 2394 0.29916275990165 753 3103253
SGTC_1488 4013-0813 75.9 µM -0.529150334345204 0.290634138132448 no 2395 0.298350583347488 757 2910057
SGTC_2124 5246320 200 µM -0.530794835121149 0.290201233422112 no 2396 0.297780479773571 765 579342
SGTC_1712 st032288 53.4 µM -0.531066365475725 0.290129783795677 no 2397 0.2976863954208 769 2883011
SGTC_2866 9034245 58.44 µM -0.532291546266674 0.289807496213356 no 2398 0.297262043181926 758 6462273
SGTC_2491 paeonol 100 µM -0.534305627447064 0.289278051256837 no 2399 0.296565049716816 790 11092 Increases levels of cortical cytochrome oxidase.
SGTC_381 3461-2219 42.7 µM -0.534575797251002 0.289207065853401 no 2400 0.296471611662886 799 2883159
SGTC_645 0845-0943 5.41 µM -0.535759202274726 0.288896230216514 no 2401 0.296062490859944 762 1885106
SGTC_1154 4088-0362 150 µM -0.535979580578036 0.288838362560758 no 2402 0.295986331415709 778 6618304
SGTC_280 3448-3607 3.04 µM -0.536352047339 0.288740571425519 no 2403 0.295857632926693 773 626179
SGTC_2998 9066762 71.4286 µM -0.537167270009331 0.288526589160339 no 2404 0.295576038657684 780 4945196
SGTC_1320 1313-0481 95.3 µM -0.53734461897216 0.288480047932906 no 2405 0.295514795090156 778 6813365 YLR208W SEC13
SGTC_2473 5854593 8.94 µM -0.538798584779935 0.288098620935019 no 2406 0.295012920121782 773 2872951
SGTC_1624 st003710 6.25 µM -0.539711405957998 0.287859277111263 no 2407 0.294698036389556 799 24207033
SGTC_3277 9138724 49.47 µM -0.539834561814992 0.287826992551746 no 2408 0.294655564827981 776 15943418
SGTC_260 nsc-65238 3.989 µM -0.540248310713963 0.287718543318226 no 2409 0.294512899952629 759 3246252
SGTC_3205 9113483 49.47 µM -0.540893741489998 0.287549405664755 no 2410 0.294290412456897 785 17018033
SGTC_715 0868-0130 184 µM -0.54108761994597 0.287498608241385 no 2411 0.294223595462556 779 2876258
SGTC_132 0417-1715 25.805 µM -0.541640946021932 0.287353656532087 no 2412 0.294032939360725 801 6769098
SGTC_1634 st006576 41 µM -0.543524305711594 0.286860542717298 no 2413 0.293384430323365 783 3915356
SGTC_1895 st058434 18.3 µM -0.545546545717532 0.286331513202934 no 2414 0.292688838504023 807 5393175
SGTC_1153 4055-0057 267 µM -0.545667586729431 0.286299862880814 no 2415 0.292647228219514 775 882706
SGTC_2848 9016370 25.97 µM -0.547906034661701 0.285714843542785 no 2416 0.29187821248556 766 7894410
SGTC_1293 1000-1278 195 µM -0.548137643017773 0.285654345077557 no 2417 0.291798697514264 794 678847
SGTC_2600 tangeritin 87.95 µM -0.548664236936943 0.285516816062548 no 2418 0.291617946700554 777 68077 A bioactive flavone.
SGTC_1041 0206-0046 107 µM -0.548874529250388 0.285461903433985 no 2419 0.29154577946951 796 50494
SGTC_1743 st037606 46.3785 µM -0.549613157719308 0.285269068764597 no 2420 0.291292366082201 734 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_875 0709-0210 25.7 µM -0.549737286241526 0.285236668466346 no 2421 0.291249789365827 791 6251364
SGTC_3328 9140624 29.0385 µM -0.549906474082746 0.285192509510073 no 2422 0.291191761751856 793 4904392
SGTC_1003 4049-0218 100 µM -0.551299007552376 0.284829174439996 no 2423 0.290714359357859 786 295161
SGTC_981 1488-1094 54.9 µM -0.553347392602818 0.284295118552031 no 2424 0.290012777299669 778 3449522
SGTC_199 4063-0024 41.6 µM -0.553878227071526 0.284156797277512 no 2425 0.289831093443129 776 306215
SGTC_1424 4048-1941 275 µM -0.555618626480457 0.283703521577319 no 2426 0.289235797668558 775 X1424
SGTC_2293 7624732 200 µM -0.556548184941967 0.283461566078838 no 2427 0.28891808202957 788 894453
SGTC_2718 lomofungin 53.02 µM -0.556564708957687 0.283457265924745 no 2428 0.288912435739254 792 5351222 A RNA synthesis inhibitor.
SGTC_577 r071-0003 38.6 µM -0.556914976584704 0.283366120816493 no 2429 0.288792760785612 798 4568517 YMR134W ERG29
SGTC_474 dl-dihydrosphingosine 5 µM -0.557264525271707 0.28327517679874 no 2430 0.288673354740985 764 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_1391 3442-0225 151 µM -0.559431718095806 0.282711638911766 no 2431 0.287933559830909 764 5227075
SGTC_2739 tacrine 100.86 µM -0.562537815105088 0.281904897128773 no 2432 0.286874823353969 776 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_2957 9076800 11.52 µM -0.562641100056338 0.281878090152742 no 2433 0.286839649616727 789 16459615
SGTC_325 2810-4341 181 µM -0.563682800833411 0.281607791786898 no 2434 0.286485012250548 769 774970
SGTC_2044 5102272 200 µM -0.564601064421564 0.281369626354095 no 2435 0.286172570558838 775 592666
SGTC_1243 0416-0003 5.65 µM -0.565012213606943 0.281263020164389 no 2436 0.286032728403825 788 2141977
SGTC_2026 5148700 152 µM -0.567047416110966 0.280735603260903 no 2437 0.28534098362051 758 79838
SGTC_2787 5284540 71.43 µM -0.568179449649182 0.28044244717538 no 2438 0.284956562041749 795 736958
SGTC_2806 7952793 58.44 µM -0.569439455143327 0.280116325316499 no 2439 0.284528973797724 796 2972490
SGTC_1706 st031321 9.9705 µM -0.569744922812332 0.280037290107951 no 2440 0.284425358210272 774 6103185
SGTC_2193 5925765 200 µM -0.570259967847986 0.279904054361552 no 2441 0.284250694161044 779 877370
SGTC_3082 9117008 49.47 µM -0.571957705271049 0.27946508860662 no 2442 0.283675314300199 778 41448529
SGTC_408 cantharidin 100 µM -0.57375693646758 0.279000245905421 no 2443 0.283066146745495 774 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1029 k015-0030 64.7 µM -0.573923270154993 0.278957291547854 no 2444 0.283009862696707 776 2208316
SGTC_3293 9120939 62.045 µM -0.575204947543836 0.278626416450838 no 2445 0.282576348553027 804 934087
SGTC_1913 st060213 96.1 µM -0.578808556255555 0.277697141898222 no 2446 0.281359178575813 797 688959
SGTC_2040 5100729 123 µM -0.579417426519367 0.277540280122756 no 2447 0.281153774171138 791 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_1734 st037168 69.4 µM -0.57984474262166 0.277430217571283 no 2448 0.281009660929557 800 708907
SGTC_163 TUB2.036 7.546 µM -0.580138027179395 0.277354689480092 no 2449 0.280910770764965 804 15992207 YJR013W GPI14
SGTC_2545 solidagenone 89.61 µM -0.581287750310407 0.277058704085343 no 2450 0.2805232675531 750 6708572 An anti ulcer agent
SGTC_2049 5262831 67.185 µM -0.582562330501064 0.276730756210843 no 2451 0.280093985063197 791 763417
SGTC_2153 5569715 200 µM -0.582758429741658 0.276680317010441 no 2452 0.280027966512935 780 2054701
SGTC_1125 tnp00248 1.32998 µM -0.582976706780249 0.276624178698993 no 2453 0.27995449048227 778 24207736
SGTC_1676 st018489 23.4 µM -0.582979635837866 0.276623425417457 no 2454 0.279953504571641 793 3696235
SGTC_3145 9085516 49.47 µM -0.58436374250838 0.276267579772305 no 2455 0.279487807528322 795 25236195
SGTC_999 SEC7.066 22.7 µM -0.58552471691758 0.275969273428096 no 2456 0.279097475983333 788 740511 YDR170C SEC7
SGTC_2006 4011487 200 µM -0.586636593798566 0.275683730821313 no 2457 0.27872390018829 785 45595294
SGTC_928 2764-0428 58.7 µM -0.587589302716297 0.275439179949227 no 2458 0.278403996475124 805 662578
SGTC_1239 0337-0584 35.4 µM -0.58849911888524 0.275205738886279 no 2459 0.278098662549978 800 914301 YML130C ERO1
SGTC_416 estradiol valerate 100 µM -0.588782552066151 0.275133035370737 no 2460 0.278003575874417 800 13791 A steroid.
SGTC_2137 5261020 140 µM -0.59008799205908 0.274798298787722 no 2461 0.277565829419486 791 763655
SGTC_1642 st009582 77.7 µM -0.590321086026797 0.27473855073822 no 2462 0.277487702675287 796 6739311
SGTC_836 0330-0104 1.35 µM -0.590398406474162 0.274718732910363 no 2463 0.277461789343117 774 46494820
SGTC_1545 lovastatin 49.4 µM -0.590415317176997 0.274714398660557 no 2464 0.277456122013381 786 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_841 0251-0215 91.2 µM -0.591037653058595 0.274554916082457 no 2465 0.277247596267358 800 3888614
SGTC_752 1896-0090 130 µM -0.592253984051579 0.274243345597025 no 2466 0.27684026235886 798 772567
SGTC_1925 st057770 10.1 µM -0.592440359811253 0.27419561975904 no 2467 0.276777873374385 785 5989122
SGTC_2679 rapamycin 1 nM -0.592942682124462 0.274067008905899 no 2468 0.276609756097542 792 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_3110 9122132 49.47 µM -0.594733943155901 0.273608630611097 no 2469 0.27601066447409 771 918317
SGTC_1224 0823-0416 294 µM -0.594834590198592 0.273582886597026 no 2470 0.275977021741098 800 3598164
SGTC_3296 9122258 64.045 µM -0.597145497960636 0.272992120758785 no 2471 0.275205121782821 800 4730474
SGTC_102 gallobenzophenone 83.616 µM -0.597428503124952 0.272919816153068 no 2472 0.275110664213659 790 70837
SGTC_3096 9117468 49.47 µM -0.597535503196294 0.272892481324156 no 2473 0.275074955362287 802 41316311
SGTC_1550 gossypolone 36.6 µM -0.598866727655401 0.272552512945608 no 2474 0.274630880314029 790 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_178 4092-0806 87.505 µM -0.601141568190659 0.271972050783924 no 2475 0.273872849471192 791 2169044
SGTC_2080 5212524 12.4 µM -0.602303951238589 0.271675687585666 no 2476 0.273485915593571 814 260183
SGTC_2946 9065502 71.43 µM -0.602567337468014 0.271608556524102 no 2477 0.273398277249488 773 16489101
SGTC_2760 etidronate 98.04 µM -0.604220472624374 0.271187399289806 no 2478 0.27284853575879 805 3305 A chelator and antioxidant.
SGTC_167 3672-0051 66.205 µM -0.604290598198539 0.271169541108084 no 2479 0.272825227992034 784 3237971
SGTC_1240 0356-0016 42.1 µM -0.604435884342264 0.27113254439843 no 2480 0.272776942110731 773 4305613
SGTC_921 1561-0023 372 µM -0.604557326766552 0.271101621356599 no 2481 0.272736583948113 803 24050882
SGTC_1752 st044819 83.042 µM -0.604874818466156 0.271020786344547 no 2482 0.272631088018015 786 441209 YML126C ERG13
SGTC_716 1683-5115 658 µM -0.604973938243045 0.27099555240491 no 2483 0.272598156713803 812 723597
SGTC_919 tnp00227 403.569 nM -0.605553665257833 0.270847988823509 no 2484 0.272405589231127 814 1269246 A methoxyflavone. YNL221C POP1
SGTC_2820 7989630 71.43 µM -0.606050474162094 0.270721563117003 no 2485 0.272240618373124 765 2984098
SGTC_1618 st003135 44.5 µM -0.606142395856694 0.27069817452618 no 2486 0.272210100207783 829 1270615
SGTC_888 0916-0002 6.97 µM -0.608103554486398 0.270199417106869 no 2487 0.271559397461307 781 2802138 YIL048W NEO1
SGTC_618 k072-0232 33.2 µM -0.61068457417547 0.269543719201414 no 2488 0.270704210119944 806 5872756 YGL099W LSG1
SGTC_1279 0874-0590 65.2 µM -0.61114344294435 0.269427228932425 no 2489 0.27055231082607 795 3523074
SGTC_585 0kpi-0023 191 µM -0.613216459591849 0.268901279344959 no 2490 0.269866611417678 788 64601
SGTC_2117 5521686 200 µM -0.616530502663363 0.268061538437471 no 2491 0.268772223312472 793 803312
SGTC_115 0527-0192 112.043 µM -0.621935904915657 0.26669470933304 no 2492 0.266992007310387 827 4233931
SGTC_644 1498-1197 63.3 µM -0.623383474209554 0.266329270825199 no 2493 0.26651627755674 800 6741615
SGTC_2766 oltipraz 83.91 µM -0.625210435248935 0.265868416974298 no 2494 0.265916476955138 810 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.625337441428468 0.265836394491689 no 2495 0.265874805621052 809 390807
SGTC_1981 st071826 47 µM -0.62598418301565 0.265673359750782 no 2496 0.265662657960691 783 11838600
SGTC_212 3807-4682 38.772 µM -0.628105785962797 0.265138888755416 no 2497 0.264967321506059 806 3125501 YBL034C STU1
SGTC_3333 9141820 12.094 µM -0.628191249331942 0.265117370400569 no 2498 0.264939331037612 793 1939433
SGTC_1105 epirubicin 18.1 µM -0.629438207995599 0.264803506410715 no 2499 0.264531105323363 802 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_162 k030-0015 37.8 µM -0.630647828536926 0.264499221168605 no 2500 0.264135409293638 826 1809920 YMR134W ERG29
SGTC_2309 7664088 163.95 µM -0.631203873575842 0.264359405367898 no 2501 0.263953614773235 803 704922
SGTC_1736 st036774 51 µM -0.631340025133213 0.264325176216014 no 2502 0.263909110821556 819 1272247
SGTC_3276 9139060 49.47 µM -0.631802982623242 0.264208803374664 no 2503 0.263757812214409 825 4870619
SGTC_1236 0330-0013 258 µM -0.632095401416342 0.264135312005478 no 2504 0.263662269963102 812 4617066
SGTC_2352 9027995 87.8 µM -0.632863990182587 0.263942198162107 no 2505 0.263411232487949 794 2997347
SGTC_39 0986-0283 58.349 µM -0.633919559536894 0.263677095574128 no 2506 0.263066660014414 785 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_2558 carylophyllene oxide 100 µM -0.634340859307818 0.263571325532055 no 2507 0.262929198287813 828 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_29 0299-0004 12.984 µM -0.636504890165953 0.263028372957656 no 2508 0.262223697325565 805 16871 A napthoquinone isolated from Swertia calycina.
SGTC_1428 4049-0204 61.7 µM -0.641778683521552 0.261707583239675 no 2509 0.260508446069429 824 X1428
SGTC_963 1269-2853 151 µM -0.642124461153112 0.261621104345314 no 2510 0.260396187323497 792 3668223
SGTC_2314 7727897 200 µM -0.643572415478677 0.261259130714182 no 2511 0.259926371201882 797 900724
SGTC_1569 carminic acid 40.6 µM -0.644027943600658 0.261145306618962 no 2512 0.259778656964377 811 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_890 0929-0006 47.2 µM -0.644180310455797 0.261107239972632 no 2513 0.259729258588995 810 1378169
SGTC_2090 5301565 104.445 µM -0.644890866351684 0.260929755572134 no 2514 0.259498955548796 805 2056344
SGTC_779 1360-0071 233 µM -0.647970116175003 0.260161330634908 no 2515 0.25850213941924 817 7566
SGTC_2339 9000433 200 µM -0.648422743577568 0.260048476149049 no 2516 0.258355782040234 800 2988954
SGTC_931 2812-0076 566 µM -0.649565245204108 0.259763726267984 no 2517 0.257986544425424 829 3450959
SGTC_481 bay k-8644 50 µM -0.652046309796776 0.25914591598228 no 2518 0.257185649101157 833 2303 A calcium channel antagonist.
SGTC_1308 1187-1617 41.4 µM -0.65222722283619 0.259100896530591 no 2519 0.257127300420034 822 2882570
SGTC_2270 7924575 90.91 µM -0.652250070363179 0.259095211306851 no 2520 0.257119932048492 819 1262135
SGTC_536 3852-0578 10.6 µM -0.652673911260612 0.258989757308739 no 2521 0.256983262455809 818 2869208
SGTC_1383 3049-0032 20.7 µM -0.653339862585367 0.258824109728219 no 2522 0.25676859952356 833 712864
SGTC_2670 beta-carotene 100 µM -0.65555072515636 0.25827457697404 no 2523 0.256056619359893 784 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_2098 5376439 882.5 nM -0.655727126059664 0.258230756769405 no 2524 0.255999856086012 804 2844116
SGTC_2148 5546263 113.568 µM -0.65834718021733 0.257580356339096 no 2525 0.255157533835498 808 792097
SGTC_3004 9076122 71.4286 µM -0.660450726703667 0.25705878979286 no 2526 0.254482314300531 828 44782551
SGTC_392 N-ethylmaleimide 8.33 µM -0.66116815842247 0.256881030960612 no 2527 0.254252239454688 809 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_1788 fluconazole 20 µM -0.661488657446899 0.256801641246645 no 2528 0.25414949313185 835 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_253 dyclonine 31.25 µM -0.661974908734568 0.256681217998184 no 2529 0.253993651154527 817 3180 An oral anasthetic.
SGTC_2271 7849410 118.62 µM -0.666249409106693 0.255623877264291 no 2530 0.252625848179141 835 972430
SGTC_2458 5808907 16.39 µM -0.667192638485822 0.255390866705968 no 2531 0.252324546360677 837 2731747
SGTC_3040 9091894 49.47 µM -0.670250277239264 0.25463628710762 no 2532 0.251349129133069 788 25236966
SGTC_3229 9132204 49.47 µM -0.67108253001855 0.254431101899676 no 2533 0.251083977740818 825 17682924
SGTC_2151 5563267 85.4165 µM -0.671898465521461 0.254230023729689 no 2534 0.25082416866992 841 5310824
SGTC_401 neomycin 50 µM -0.672302302389952 0.254130533489673 no 2535 0.250695632157726 805 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_1897 st060201 15 µM -0.674289061422224 0.253641368187919 no 2536 0.250063778506817 828 611878
SGTC_587 k089-0003 57 µM -0.674970069175283 0.253473809313226 no 2537 0.249847390608647 825 9659696
SGTC_1128 3448-9350 235 µM -0.678113589294661 0.252701114977446 no 2538 0.248849837560675 810 619386
SGTC_792 4534-1957 155 µM -0.678712216959059 0.252554109773972 no 2539 0.248660111881572 824 1717904
SGTC_1770 st043884 66.3 µM -0.678923096481888 0.252502334749648 no 2540 0.248593295268467 843 670149
SGTC_1839 st053978 48 µM -0.679304152305973 0.252408792319327 no 2541 0.248472583009273 832 3788398
SGTC_3220 9131269 49.47 µM -0.680251990651786 0.25217619409871 no 2542 0.248172458836024 837 17722206
SGTC_738 1315-0003 72.4 µM -0.681026729143828 0.251986158339575 no 2543 0.247927288792 850 6251474
SGTC_2886 9058944 51.95 µM -0.681182407155592 0.251947981169264 no 2544 0.247878039273204 787 4949929
SGTC_294 k038-0071 157 µM -0.6844375796711 0.251150409671821 no 2545 0.246849446362668 834 24152826
SGTC_1845 st056753 3.01 µM -0.684518895993786 0.251130502928948 no 2546 0.246823780725935 817 5375839
SGTC_248 streptozotocin 5.23457 mM -0.68455365771526 0.251121993297424 no 2547 0.24681280941978 847 5300 DNA alkylating agent.
SGTC_182 3448-4371 550.524 µM -0.687560945662839 0.25038639023524 no 2548 0.245864654511538 797 3491403
SGTC_1106 tegaserod maleate 11.7 µM -0.688242847280404 0.25021975146391 no 2549 0.245649932904376 834 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_1032 k061-1018 98.7 µM -0.688245487510986 0.250219106375505 no 2550 0.245649101727198 838 4005393
SGTC_1241 0364-0022 50.8 µM -0.688895236046689 0.25006037992129 no 2551 0.245444598796612 841 4563895
SGTC_3097 9117246 49.47 µM -0.689038747930696 0.250025328742971 no 2552 0.245399441966001 823 16423892
SGTC_164 4100-3994 89.624 µM -0.689143772663772 0.249999679274407 no 2553 0.245366398165822 852 4615967
SGTC_1948 st076329 66.6 µM -0.692539206352882 0.249171188663908 no 2554 0.244299386687098 828 24208413
SGTC_3353 9151644 39.2805 µM -0.693893247066985 0.248841208556763 no 2555 0.243874579418191 828 4909158
SGTC_1450 4112-4260 37.6 µM -0.694237765506351 0.248757286455771 no 2556 0.243766556261844 835 1633175
SGTC_1462 k081-0014 26.5 µM -0.694992824575301 0.2485734124654 no 2557 0.243529899167608 806 3270634
SGTC_181 1447-1644 8.07 µM -0.695826630886013 0.248370445895854 no 2558 0.243268704693561 851 534600
SGTC_1220 1838-0075 193 µM -0.695954049217199 0.24833943728913 no 2559 0.243228803533272 821 5529645
SGTC_360 0957-0399 1.01 µM -0.696728806172533 0.248150936373035 no 2560 0.242986263899296 833 6752301 YPR165W RHO1
SGTC_2869 9037858 32.47 µM -0.697367535995161 0.247995588716644 no 2561 0.242786406335096 831 27187042
SGTC_2532 xanthone 78.9 µM -0.698557035213215 0.247706424918181 no 2562 0.242414451129162 817 7020 An insecticide.
SGTC_1612 st002233 45.4 µM -0.69896519230938 0.247607244622665 no 2563 0.242286891994786 824 1035021
SGTC_568 1193-0097 7.48 µM -0.699579150324573 0.247458095612554 no 2564 0.242095083544241 814 3646150
SGTC_960 1222-0186 7.7 µM -0.703113505942712 0.246600428012947 no 2565 0.240992507982378 842 3126296
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.703393215360711 0.246532620131936 no 2566 0.240905366756201 840 616764
SGTC_898 1000-0849 28.3 µM -0.706690150754259 0.245734121842557 no 2567 0.23987952580135 849 6751807
SGTC_2650 prasterone 100 µM -0.707058180150108 0.245645073530576 no 2568 0.239765161527793 817 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_2647 atorvastatin 60.16 µM -0.707245381006336 0.245599785102721 no 2569 0.239707000716435 818 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_3342 9147791 14.508 µM -0.711317567640911 0.244615735160143 no 2570 0.238443733832749 832 1838168
SGTC_1749 st037932 54.2 µM -0.713119179458497 0.244181051482922 no 2571 0.237886006109703 874 594497
SGTC_2405 ticlatone 3.52 µM -0.714077157887518 0.243950085073162 no 2572 0.237589734825317 843 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_1801 st050089 28.441 µM -0.714303567665056 0.243895515418922 no 2573 0.237519743307476 835 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_608 k048-0125 159 µM -0.714595409122945 0.243825185032701 no 2574 0.237429541169292 835 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_2888 9058547 12.99 µM -0.714664502088904 0.243808536036646 no 2575 0.23740818872093 832 16476514
SGTC_1947 st076332 61.6 µM -0.716567175827504 0.243350299190999 no 2576 0.236820602035094 853 24208416
SGTC_1657 st012939 43.4 µM -0.718164178735192 0.242966039173623 no 2577 0.23632803102819 832 24207257
SGTC_455 paf C-16 10 µM -0.718242189138856 0.242947277251093 no 2578 0.236303984376642 837 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_1380 2291-0730 164 µM -0.719142390288224 0.242730830740832 no 2579 0.236026595506652 829 2999191
SGTC_2181 6316240 54.2555 µM -0.720797463986333 0.242333153408208 no 2580 0.235517067978353 851 12779990
SGTC_548 1436-0017 110 µM -0.722530882180882 0.241917030450555 no 2581 0.234984072793253 833 9677137
SGTC_2101 5377231 179.231 µM -0.722881834719245 0.241832828281284 no 2582 0.234876242328811 854 2844213
SGTC_1510 1123-0200 71.5 µM -0.72476077824886 0.241382293995091 no 2583 0.234299400731685 859 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_610 4215-0184 155 µM -0.726189896810321 0.241039924573868 no 2584 0.233861182366662 825 5605015
SGTC_2724 maprotiline 69.64 µM -0.72647430769233 0.24097182067501 no 2585 0.233774026135903 851 4011 A tricyclic antidepressant.
SGTC_953 1188-0045 9.7 µM -0.727015837162011 0.240842177119907 no 2586 0.233608127039897 846 6144426
SGTC_2749 bexarotene 57.39 µM -0.72926377442585 0.240304421059303 no 2587 0.232920163472226 854 82146 An retinoic acid receptor inhibitor.
SGTC_1815 st051655 58.2 µM -0.729700729543445 0.240199967771841 no 2588 0.232786567545885 846 5984156
SGTC_97 0535-0701 19.132 µM -0.731353692046641 0.239805054182775 no 2589 0.232281571386372 836 2832013 YGL099W LSG1
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.731789722508175 0.239700940081053 no 2590 0.232148461501589 861 688798
SGTC_657 3534-0529 86.7 µM -0.732325905353826 0.23957294570492 no 2591 0.231984835659182 856 1049549
SGTC_1975 st070967 30.8 µM -0.73305538781653 0.23939886792216 no 2592 0.231762324113216 848 261391
SGTC_2229 7354935 190 µM -0.735054499480317 0.238922170374805 no 2593 0.231153151751019 858 318112
SGTC_1301 naphtanilide LB 4.81 µM -0.736022813537247 0.238691458084968 no 2594 0.230858407107913 851 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_1837 st055472 66.5 µM -0.738210568258276 0.238170648753357 no 2595 0.230193250892758 838 676091
SGTC_3002 9075603 71.4286 µM -0.73932367426633 0.237905905762817 no 2596 0.229855238484481 850 20105405
SGTC_1267 0828-0272 9.49 µM -0.739377752153139 0.237893047899276 no 2597 0.229838823951761 847 745334
SGTC_2839 9003951 25.97 µM -0.740805418282501 0.237553735797707 no 2598 0.229405714719917 828 2990634
SGTC_3272 9137413 49.47 µM -0.744529611879074 0.236669861564343 no 2599 0.22827806673652 858 17614870
SGTC_2567 aureobasidin a 60 nM -0.747001475686165 0.236084206891753 no 2600 0.227531335034361 868 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_1292 0kpi-0043 232 µM -0.749203278784389 0.235563210336231 no 2601 0.226867346628545 848 3333905
SGTC_2464 5717415 7.67 µM -0.750818489306216 0.235181418578901 no 2602 0.22638095027326 851 5285744
SGTC_1159 4092-0538 61.2 µM -0.752958772987809 0.234676040667178 no 2603 0.225737344241018 877 717301
SGTC_2723 salbutamol 83.58 µM -0.754198734148727 0.234383527805668 no 2604 0.22536494879877 855 9884233 β2-adrenoceptor agonist
SGTC_110 0850-0284 111.64 µM -0.754596056968921 0.234289840124071 no 2605 0.225245695135551 815 3906265
SGTC_1370 2001-0092 44.6 µM -0.754670732435062 0.234272234158823 no 2606 0.225223285807728 850 790957
SGTC_1572 epiandrosterone 68.9 µM -0.754811814205482 0.234238973817659 no 2607 0.225180952087968 844 441302 A steroid.
SGTC_2128 5255449 168.493 µM -0.755507062645107 0.234075105640209 no 2608 0.224972398125991 846 736008
SGTC_153 4077-0274 519.67 µM -0.755881187922058 0.233986951605442 no 2609 0.22486021693226 848 3121976
SGTC_1055 3448-0672 86 µM -0.756653431540866 0.233805048293049 no 2610 0.224628760559093 843 748378
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.758846616199339 0.233288867478538 no 2611 0.223972158080088 850 66535 A nucleotide analog.
SGTC_685 1278-0033 54.9 µM -0.760418934383912 0.232919201334757 no 2612 0.223502104444448 864 3590572
SGTC_889 0919-1524 82.7 µM -0.760997438352002 0.23278327177695 no 2613 0.223329298648979 860 3905452
SGTC_52 0329-0193 875 nM -0.761268302103897 0.232719642786972 no 2614 0.223248414669452 873 3739292
SGTC_2123 5259487 200 µM -0.762592144275832 0.23240879624665 no 2615 0.222853335518271 841 2173474
SGTC_564 3555-0129 330 µM -0.764361352474221 0.231993735723516 no 2616 0.222325966557084 846 563260
SGTC_1305 1181-0477 144 µM -0.765491277801885 0.231728868630652 no 2617 0.221989529143745 868 6252086
SGTC_701 4424-0219 185 µM -0.766213185733362 0.23155973361503 no 2618 0.22177473196045 854 2911779
SGTC_2066 5222451 176 µM -0.766722402552145 0.231440471167001 no 2619 0.221623290535141 845 2281147
SGTC_1489 4065-0444 182 µM -0.767231455033317 0.231321281449295 no 2620 0.221471957070754 843 2877968
SGTC_2068 5226020 147 µM -0.768024150956609 0.231135747545686 no 2621 0.221236418441433 872 1810509
SGTC_1394 3474-0001 65.7 µM -0.768681816806505 0.230981881061368 no 2622 0.221041110933363 836 5017666 YIL048W NEO1
SGTC_1115 galangin 695.678 nM -0.772189462400904 0.23016220420878 no 2623 0.220001110881899 886 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_824 1304-0008 100 µM -0.773083441009515 0.229953557187208 no 2624 0.2197365001639 864 768245
SGTC_2394 5221648 200 µM -0.774975538667366 0.229512306987953 no 2625 0.219177056996055 875 788586
SGTC_183 3914-0051 30.55 µM -0.776649098697111 0.229122416994444 no 2626 0.218682912767996 845 1596232
SGTC_2476 5806916 10.51 µM -0.778998448023758 0.228575715419069 no 2627 0.217990314486121 851 2870194
SGTC_574 1315-0397 40 µM -0.780881196360227 0.228138122849886 no 2628 0.217436186204487 871 6794277
SGTC_594 1487-1584 10.8 µM -0.781713079237362 0.227944924924339 no 2629 0.217191606681106 887 5013332
SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.783523356809795 0.227524821153085 no 2630 0.21665992166249 874 94937 An inhibitor of serotonin biosynthesis.
SGTC_2135 5326629 150.42 µM -0.78427047140565 0.227351568491534 no 2631 0.216440711075257 880 5020077
SGTC_3334 9142812 21.919 µM -0.788087641258555 0.226467544148556 no 2632 0.21532272183292 863 45283678
SGTC_712 r015-0009 80.6 µM -0.78909513023452 0.226234542360649 no 2633 0.215028203981949 880 6813872 YLR060W FRS1
SGTC_3108 9121785 49.47 µM -0.789106992167598 0.226231799860545 no 2634 0.215024737793377 847 17140271
SGTC_2861 9024595 19.48 µM -0.791107444196279 0.225769560553912 no 2635 0.214440647756091 832 16482810
SGTC_3157 9099274 49.47 µM -0.791875143792161 0.225592312127977 no 2636 0.214216740769134 846 17217662
SGTC_2827 7993847 71.43 µM -0.793911205955582 0.225122602517389 no 2637 0.213623562771494 835 2985692
SGTC_2772 vinpocetine 57.06 µM -0.794078869085979 0.225083948158658 no 2638 0.21357475916583 878 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_1411 3909-8223 150 µM -0.794566661226235 0.224971510163366 no 2639 0.213432808935074 868 X1411
SGTC_2808 7946468 45.46 µM -0.794974322242403 0.224877567129473 no 2640 0.213314219502248 887 2970879
SGTC_2703 st077852 53.4 µM -0.796424325600304 0.224543602845354 no 2641 0.212892721988511 881 6281836
SGTC_2048 5246248 200 µM -0.798822114641303 0.223991962775545 no 2642 0.21219678276232 855 677046
SGTC_2338 7999974 200 µM -0.79898558552108 0.22395438239959 no 2643 0.212149385112071 876 315925
SGTC_814 3342-0569 96 µM -0.799481848663484 0.223840318246499 no 2644 0.212005533756867 870 4346283
SGTC_217 ketoconazole 989 nM -0.799678588538447 0.223795107492851 no 2645 0.211948520738864 835 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_2164 5685496 200 µM -0.800046659236349 0.223710538917437 no 2646 0.211841882049043 891 759046
SGTC_1341 1486-1360 280 µM -0.801064562419776 0.223476758305308 no 2647 0.211547135186122 891 3976547
SGTC_2694 st077685 81.9 µM -0.804525173310707 0.222683004164771 no 2648 0.21054686852956 869 2838096
SGTC_3155 9099265 49.47 µM -0.806951589277853 0.22212742115862 no 2649 0.209847187367756 857 25236499
SGTC_532 1548-0774 215 µM -0.807520905798562 0.221997177908252 no 2650 0.209683217473839 897 5932993
SGTC_993 3909-8757 62.7 µM -0.807563188490142 0.221987506583879 no 2651 0.209671042564681 858 4288324 YLR208W SEC13
SGTC_692 k241-0027 77.8 µM -0.810191831186816 0.221386729405771 no 2652 0.208914965838007 851 3600480
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.811919713416803 0.220992328278826 no 2653 0.208418850972085 899 689007
SGTC_2846 9008642 19.48 µM -0.81273880820887 0.220805504795438 no 2654 0.208183912922245 894 2992898
SGTC_893 0958-0369 48.9 µM -0.813305532491763 0.220676296266927 no 2655 0.20802145291708 872 6819948
SGTC_3339 9145883 14.936 µM -0.815883819778874 0.220089014722835 no 2656 0.207283293550115 853 2030670
SGTC_114 0364-0001 490.298 µM -0.818603754817931 0.219470441575856 no 2657 0.206506262013827 877 4003655
SGTC_2348 9022543 33.42 µM -0.81903684134458 0.219372040417329 no 2658 0.206382697220282 861 3162678 YDL140C RPO21
SGTC_3187 9109394 49.47 µM -0.82044769542521 0.21905165753818 no 2659 0.205980467536867 873 17098090
SGTC_2289 7946404 165.07 µM -0.820482481033873 0.219043761671351 no 2660 0.205970556155367 866 1246120 YPR165W RHO1
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.82172843131997 0.218761055601405 no 2661 0.205615737027598 885 6708784 An antioxidant flavonoid
SGTC_665 3914-0008 307 µM -0.821803999005743 0.218743916052939 no 2662 0.205594228696232 884 1069549
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.822136052769427 0.218668611915136 no 2663 0.2054997342561 895 91467 include heat shock
SGTC_1827 berberine 7.24 µM -0.82252924679618 0.218579461506268 no 2664 0.205387874135441 856 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_907 3448-6986 75.5 µM -0.822903136134436 0.218494707537475 no 2665 0.205281539573785 899 590582
SGTC_3189 9110682 49.47 µM -0.823814996699281 0.218288084571405 no 2666 0.205022342553532 887 17122418
SGTC_1699 st031318 29.054 µM -0.826000557686131 0.217793306092967 no 2667 0.204401887725995 872 5340658
SGTC_1077 5-fluorocytosine 377 nM -0.826483590480961 0.217684042006914 no 2668 0.204264911410571 893 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.827267241146161 0.217506844166961 no 2669 0.204042803505422 861 688669
SGTC_2248 tofa 1.1 µM -0.828920687181954 0.217133242870951 no 2670 0.203574644253559 867 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1047 2043-3044 82 µM -0.829916945155986 0.216908314378725 no 2671 0.203292871783444 913 669592
SGTC_1492 4158-0558 28.5 µM -0.830022707821528 0.216884443899098 no 2672 0.203262972512718 856 3967268
SGTC_431 k089-0097 107 µM -0.831941606517205 0.216451615054543 no 2673 0.202720952756696 865 5499420
SGTC_3035 9091303 49.47 µM -0.832570101878452 0.216309959712892 no 2674 0.202543613393046 890 25237002
SGTC_1091 telmisartan 47.6 µM -0.834997046773015 0.215763459327574 no 2675 0.201859685585255 900 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_1210 3013-0140 750 nM -0.83595553042885 0.215547848256199 no 2676 0.201589960388379 874 905973
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.840810683982721 0.214457601879177 no 2677 0.200227000413289 901 688751
SGTC_1381 2324-0066 62.1 µM -0.840877485800234 0.214442623629776 no 2678 0.200208286217525 875 10885928
SGTC_3109 9122853 49.47 µM -0.841048867068346 0.214404199442959 no 2679 0.200160279418511 924 1234709
SGTC_2692 st077426 47.7 µM -0.844860299885841 0.213550700118974 no 2680 0.199094421254245 884 25238571
SGTC_2057 5236571 38.335 µM -0.844961832533945 0.213527990881035 no 2681 0.199066074727345 889 54684039 YBR257W POP4
SGTC_1468 k284-1086 134 µM -0.84627671070779 0.213234026598553 no 2682 0.198699198415297 883 15996457
SGTC_647 0140-0236 81 µM -0.848247007673117 0.21279397391196 no 2683 0.198150211478695 891 990837
SGTC_1716 st033144 30.6155 µM -0.848734925690078 0.212685082628177 no 2684 0.198014403713112 884 674617
SGTC_224 benfluorex 43.875 µM -0.850422808000239 0.212308639920216 no 2685 0.197545030009988 890 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_1010 4112-3296 15.2 µM -0.850608869014393 0.212267167200145 no 2686 0.197493330540318 900 704384
SGTC_3210 9128157 49.47 µM -0.851411825986317 0.212088243618347 no 2687 0.197270312362734 891 17590849
SGTC_1633 st005664 67.9 µM -0.851681933356091 0.212028075192556 no 2688 0.197195325347555 909 2063822
SGTC_3144 9087057 49.47 µM -0.852235702814636 0.211904750143513 no 2689 0.197041642198419 874 17249618
SGTC_367 0335-0881 7.1 µM -0.855300600092883 0.211222953456031 no 2690 0.196192377711105 889 23828853
SGTC_1132 3456-3614 2.5 µM -0.855810419433405 0.211109667244939 no 2691 0.196051325476856 908 3125502
SGTC_2955 9076254 12.21 µM -0.857178440694836 0.210805857272274 no 2692 0.195673137739613 870 16459619
SGTC_2310 7668677 200 µM -0.858737924813573 0.210459840217209 no 2693 0.195242560954407 894 2197143
SGTC_1824 st053723 68.6 µM -0.860923264816089 0.209975520096912 no 2694 0.194640153655968 885 675225
SGTC_2237 6667747 47.222 µM -0.861026478875334 0.209952661766464 no 2695 0.194611729831635 910 729940 YDL015C TSC13
SGTC_106 0092-0003 11.579 µM -0.861092936119037 0.209937944568385 no 2696 0.194593429698301 894 1072148
SGTC_2416 tofa 880 nM -0.86187484869585 0.209764832723114 no 2697 0.194378195409165 900 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1548 st061468 90.8 µM -0.862734312740204 0.209574648196154 no 2698 0.194141781090186 890 390799
SGTC_2865 9030313 51.95 µM -0.865020076596586 0.20906934200493 no 2699 0.193513884776698 896 42562754
SGTC_2401 5128683 200 µM -0.866973779263605 0.208638012708126 no 2700 0.192978188291276 913 708373
SGTC_561 1550-0330 72.9 µM -0.867019867419783 0.208627843918728 no 2701 0.192965562069788 891 6812934
SGTC_2147 5545932 89.7195 µM -0.867020151376376 0.208627781268075 no 2702 0.192965484279156 914 797404
SGTC_3191 9110352 49.47 µM -0.868830547435207 0.208228570724135 no 2703 0.192469911043493 879 17122424
SGTC_223 busulfan 5 mM -0.869487331013439 0.208083854829688 no 2704 0.192290317287924 875 2478 A DNA alkylator.
SGTC_2246 7293507 91.5585 µM -0.871071710138256 0.207734996671338 no 2705 0.191857499810184 880 887656
SGTC_2255 7941087 197.44 µM -0.87109839392688 0.207729124233582 no 2706 0.191850215497444 904 935561
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.871249513429687 0.207695868442511 no 2707 0.191808965115544 901 6710655
SGTC_1256 0570-0116 285 µM -0.871537350056004 0.207632534990534 no 2708 0.191730410724927 902 410638
SGTC_2685 mycophenolic acid 18.85 µM -0.872453156215989 0.207431103670043 no 2709 0.191480606296801 869 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_1600 coumarin 106 71.1 µM -0.874618346754034 0.206955330231053 no 2710 0.190890800862081 896 100336 A hepatotoxic, DNA x-linker.
SGTC_2257 7960413 200 µM -0.87519549660301 0.206828617893271 no 2711 0.190733771573546 868 2974689 YIL048W NEO1
SGTC_1225 1216-0074 20.6 µM -0.878015728389114 0.206210101273105 no 2712 0.189967591638478 896 4241466
SGTC_895 0964-0006 13.7 µM -0.878417442013928 0.206122089108373 no 2713 0.189858611163377 904 6738897
SGTC_108 0509-0257 621.132 µM -0.880481718550762 0.205670174438736 no 2714 0.189299202233984 892 536624
SGTC_382 3229-0966 23.2 µM -0.883351655666252 0.205042861383403 no 2715 0.188523151213114 904 5722370
SGTC_2081 5214970 32.255 µM -0.883614339388012 0.204985500641055 no 2716 0.18845221783555 907 2063512
SGTC_1608 st001473 40.5 µM -0.887858984762896 0.204059944821 no 2717 0.187308304808736 907 7292267
SGTC_2214 7179297 48.276 µM -0.891605054701173 0.203245176478993 no 2718 0.186302329944561 895 769744
SGTC_939 1165-0479 45.3 µM -0.892492775388876 0.203052382629351 no 2719 0.186064431714054 887 1377347
SGTC_135 0933-0004 26.348 µM -0.892689602887643 0.203009650722493 no 2720 0.186011709881202 874 21230617 YGL099W LSG1
SGTC_3182 9108849 49.47 µM -0.8929750836717 0.202947681435451 no 2721 0.18593525801139 891 17133045
SGTC_346 4513-0042 7.16 µM -0.894050545173556 0.202714332574852 no 2722 0.185647423979806 883 2827372
SGTC_1575 cyproterone acetate 48 µM -0.896606169164496 0.202160468183423 no 2723 0.184964552497426 916 9880 An androgen receptor antagonist and liver toxin.
SGTC_987 1497-1013 404 µM -0.896700533208711 0.202140034602934 no 2724 0.184939368016622 893 1676435
SGTC_1179 1021-1431 9.29 µM -0.897019375016259 0.202071001773037 no 2725 0.184854289236178 922 2840958
SGTC_1701 st028638 40.4 µM -0.902918575530725 0.200796305629827 no 2726 0.183284555596535 908 3490878
SGTC_1603 st002045 67.8 µM -0.903615106557174 0.200646118768447 no 2727 0.183099764069558 914 5887985
SGTC_966 1300-0360 30.2 µM -0.903923431363616 0.200579658940903 no 2728 0.183018001805794 867 70588
SGTC_1512 0259-0544 12.2 µM -0.90418421024908 0.200523458019776 no 2729 0.182948865660762 888 18476
SGTC_3349 9149703 23.001 µM -0.905317054363002 0.200279426560223 no 2730 0.182648721988271 889 4910494
SGTC_2648 atorvastatin 78.68 µM -0.905839050512801 0.20016704091273 no 2731 0.18251052420486 892 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_3015 9080845 49.47 µM -0.906006315419549 0.200131036837954 no 2732 0.182466254864935 896 5296973
SGTC_2873 9040596 71.43 µM -0.906341409529959 0.20005891893388 no 2733 0.182377587016308 910 6463863
SGTC_1795 st049545 62.3 µM -0.907097327299679 0.199896290063643 no 2734 0.182177665662933 856 5291882
SGTC_1818 st052136 56.3 µM -0.908501420974882 0.199594423079956 no 2735 0.181806681674767 880 674169
SGTC_1800 st050079 29.0735 µM -0.910779688789715 0.199105200929385 no 2736 0.181205733221367 900 3645560
SGTC_2301 7769476 200 µM -0.911149087290082 0.199025946533118 no 2737 0.181108412744703 902 977820
SGTC_1713 st033146 12.748 µM -0.916404632274226 0.197900430389249 no 2738 0.179727353312904 916 674619
SGTC_809 3998-0021 90 µM -0.919014045922156 0.197343035328028 no 2739 0.179044112741147 918 715485
SGTC_974 1326-0144 138 µM -0.919997963466063 0.197133108136632 no 2740 0.17878691173329 916 5411856
SGTC_3225 9130819 49.47 µM -0.920932740110158 0.196933790801649 no 2741 0.178542771973645 913 4547121
SGTC_316 k060-0003 58.6 µM -0.923977988154195 0.196285315720614 no 2742 0.177748888179096 904 6152314
SGTC_1617 st002906 78 µM -0.924456084061503 0.196183624547138 no 2743 0.177624453083959 923 5150859
SGTC_2767 sibutramine 71.45 µM -0.926745694017727 0.195697066675145 no 2744 0.17702929343338 915 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_139 0099-0334 718.624 µM -0.93096970686322 0.194801359343361 no 2745 0.175934617204216 932 97690
SGTC_687 k029-0044 34.9 µM -0.931232697539338 0.194745674416747 no 2746 0.175866603764973 900 5829338
SGTC_1084 voriconazole 435 nM -0.932043880832069 0.19457397768961 no 2747 0.175656924186408 918 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_3176 9106582 49.47 µM -0.933234898852826 0.194322051345061 no 2748 0.175349349775897 870 17018027
SGTC_2199 6590217 200 µM -0.935074513331954 0.1939333231859 no 2749 0.174874950060473 856 703109
SGTC_45 0kpi-0036 14.9 µM -0.93712883426865 0.193499786027463 no 2750 0.174346145506138 912 2795021
SGTC_632 0781-2353 4.65 µM -0.937795277781504 0.193359269072644 no 2751 0.174174814174198 937 6811515 YHR007C ERG11
SGTC_671 0560-0003 407 µM -0.938226171025026 0.193268450103528 no 2752 0.174064095804093 898 3238678
SGTC_3105 9121040 49.47 µM -0.939432693127276 0.193014291095409 no 2753 0.173754317060426 860 41448907
SGTC_2606 farnesol 9.78 µM -0.940329384953944 0.192825531425905 no 2754 0.173524315631384 916 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_237 nikkomycin 200 µM -0.940455990551612 0.192798889182938 no 2755 0.173491856915958 943 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_369 0957-0393 4.5 µM -0.941350553698851 0.192610705919179 no 2756 0.173262621962619 922 6997992
SGTC_47 0149-0135 24.25 µM -0.943728373222068 0.192111045984384 no 2757 0.17265423550543 917 5239155
SGTC_859 0439-0102 54.6 µM -0.946636194059826 0.191501093991318 no 2758 0.171912097007082 906 610143
SGTC_2847 9005661 71.43 µM -0.947845097891552 0.191247860770229 no 2759 0.171604159044146 893 2991449
SGTC_1973 st070275 50.2 µM -0.948343864574454 0.191143442251314 no 2760 0.171477213487065 893 17118334
SGTC_634 1611-4317 11.2 µM -0.948413940455173 0.19112877442604 no 2761 0.171459382659222 926 2843522
SGTC_2568 diosmetin 100 µM -0.950307171975608 0.190732756821097 no 2762 0.170978097872837 912 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_3321 9137793 26.8275 µM -0.951135941844757 0.190559557071487 no 2763 0.170767685719814 912 4904192
SGTC_1720 st037298 9.481 µM -0.951642243469108 0.190453795594543 no 2764 0.170639224964674 942 597396
SGTC_200 k038-0079 37.545 µM -0.953730175845951 0.190018027800553 no 2765 0.170110120702769 937 3436683
SGTC_3058 9093861 49.47 µM -0.958183513508478 0.189090631112523 no 2766 0.168985114552294 895 17217477
SGTC_3021 9087658 49.47 µM -0.959809721078102 0.188752673369969 no 2767 0.168575494454046 907 25237042
SGTC_2825 7998094 58.44 µM -0.959983019228743 0.188716680587503 no 2768 0.168531880616661 920 2987815
SGTC_595 3909-8003 73.7 µM -0.960198119727381 0.188672011641945 no 2769 0.16847775649976 938 699517
SGTC_786 4544-0069 423 µM -0.961430026509324 0.18841631271719 no 2770 0.168167996408839 909 748821 YLR208W SEC13
SGTC_1907 st060210 83.7 µM -0.961751359473916 0.188349650874882 no 2771 0.168087258275604 920 688793
SGTC_805 3852-0218 479 µM -0.96194319229675 0.188309861304719 no 2772 0.168039070245412 911 6615355
SGTC_166 k072-0058 166.424 µM -0.962214421306665 0.188253612390425 no 2773 0.167970953221198 918 5846229
SGTC_804 1595-0054 20.9 µM -0.970893874880538 0.186459098388895 no 2774 0.16580056430812 929 761523 Stimulates phospholipase C.
SGTC_2835 9006588 71.43 µM -0.971139368912601 0.186408496014255 no 2775 0.165739440743534 905 2345538
SGTC_1565 sinapyl alcohol 95.1 µM -0.971421469357362 0.186350358660261 no 2776 0.165669220837335 917 5280507 A phenol propionate derived from cinnamic acid.
SGTC_651 3253-0966 34.4 µM -0.972656994584226 0.186095864809498 no 2777 0.165361902920156 924 781462
SGTC_335 4077-0256 27.6 µM -0.973280419960282 0.185967533284713 no 2778 0.165206975540982 912 3121989
SGTC_3299 9121982 43.1275 µM -0.97344490936526 0.185933682447011 no 2779 0.165166113963773 920 17594604 YPL160W CDC60
SGTC_1146 3579-1023 7 µM -0.974593629489935 0.185697389924001 no 2780 0.164880937442368 946 X1146
SGTC_1453 4237-0541 195 µM -0.975285868969074 0.185555085786252 no 2781 0.164709239004065 905 739892
SGTC_1088 bifonazole 369 nM -0.97532965763383 0.185546086397245 no 2782 0.16469838185418 907 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_111 0083-0039 52.457 µM -0.976465612050052 0.185312721199054 no 2783 0.164416890470279 884 759313
SGTC_2894 9048625 32.47 µM -0.977152990055438 0.185171597996784 no 2784 0.16424670861067 917 4092861
SGTC_973 1325-0077 65.9 µM -0.97799491129497 0.184998837031266 no 2785 0.164038420447436 928 2835149
SGTC_421 streptovitacin 30 mM -0.980995664073765 0.184383902040465 no 2786 0.163297439876637 956 91467 include heat shock
SGTC_1961 st076550 68.7 µM -0.981893286932787 0.184200202337351 no 2787 0.163076211656811 920 1579337
SGTC_1317 1273-0028 910 nM -0.983124972381602 0.183948321738934 no 2788 0.162772967535005 905 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_696 1560-0013 611 µM -0.986939537697885 0.183169601878224 no 2789 0.161836140028931 920 1650269
SGTC_3234 9132280 49.47 µM -0.988452258296008 0.182861359581486 no 2790 0.161465602437748 918 17612295
SGTC_2050 5263056 171 µM -0.991623841635961 0.18221614778978 no 2791 0.160690527276586 913 763468 YGL055W OLE1
SGTC_1460 k062-0059 9.15 µM -0.992264733203559 0.182085940882756 no 2792 0.160534201051041 894 1373085
SGTC_3125 9127534 49.47 µM -0.99265967675901 0.18200573104402 no 2793 0.160437915938753 915 1639235
SGTC_2592 piperlongumine 83.33 µM -0.993903413495641 0.181753282546972 no 2794 0.160134946185467 952 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_2292 7671323 168.05 µM -0.995377697115328 0.181454322488279 no 2795 0.159776300835208 938 937504
SGTC_1008 4106-0037 6 µM -0.996251455490503 0.181277284276215 no 2796 0.159563991994543 927 2905394
SGTC_1958 st076513 41.9 µM -0.996871811122097 0.18115165542761 no 2797 0.15941336796895 942 732122 YGL099W LSG1
SGTC_1312 1218-2183 165 µM -0.999577194324125 0.180604423277144 no 2798 0.158757582155083 917 6744073
SGTC_759 3486-0358 89.3 µM -1.00451498002044 0.17960830740215 no 2799 0.157565227228355 943 875103
SGTC_922 1866-0035 480 µM -1.00492252437214 0.1795262466581 no 2800 0.157467078756939 916 3156169
SGTC_2876 9059903 25.97 µM -1.00569611235367 0.179370546344069 no 2801 0.157280886931373 899 6916095
SGTC_24 0417-1663 219 µM -1.00794522547193 0.178918349037017 no 2802 0.156740379282833 963 4329390
SGTC_2597 laccaic acid a 100 µM -1.01374200729003 0.177756183341159 no 2803 0.155352936964299 954 5491415 A textile dye.
SGTC_334 1502-1024 68.5 µM -1.01490184517932 0.1775242266875 no 2804 0.155076309278605 934 3296216
SGTC_2678 equilin 100 µM -1.01573242337243 0.177358236318296 no 2805 0.154878411801821 880 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_193 1273-0060 1.558 µM -1.01819770208536 0.176866129727285 no 2806 0.154292005642423 935 2847393 YHR072W ERG7
SGTC_2377 9073351 62.6 µM -1.02110561176837 0.176286777837573 no 2807 0.153602202324752 960 7337946 YHR072W ERG7
SGTC_1090 efavirenz 20.7 µM -1.02230953651629 0.17604726808376 no 2808 0.153317210524702 921 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_2130 NSC 7 2.4545 µM -1.02643978105082 0.175227160611899 no 2809 0.152342167425217 939 21448
SGTC_323 4013-0906 34.3 µM -1.02702316922738 0.175111517780871 no 2810 0.152204777164122 912 2910086
SGTC_2716 st080858 38.6235 µM -1.02779166880621 0.174959254926444 no 2811 0.152023918026919 921 5296050
SGTC_2346 9031566 143.75 µM -1.02914304940495 0.174691709650141 no 2812 0.151706229657659 936 4771086
SGTC_3195 9113082 49.47 µM -1.03070790570032 0.174382225341873 no 2813 0.151338908151531 925 17018038
SGTC_1715 st032160 10.2275 µM -1.03909569522151 0.172729300216966 no 2814 0.149380116406448 936 5289825
SGTC_1606 st000094 49.2 µM -1.04116764469819 0.172322538360807 no 2815 0.148898874650358 923 1242210
SGTC_619 1652-1634 108 µM -1.04233579285385 0.172093478972281 no 2816 0.148628011652307 959 5400454
SGTC_1754 st042065 16.137 µM -1.043234485861 0.171917388732586 no 2817 0.1484198525838 910 1126236 YIL048W NEO1
SGTC_658 3253-0951 102 µM -1.04491446762268 0.171588521152334 no 2818 0.1480312512625 953 1184878
SGTC_2395 5646831 180.19 µM -1.04586027795734 0.171403549469998 no 2819 0.147812773082311 968 6808628
SGTC_2584 androsterone 48.74 µM -1.05195033237859 0.170215574403993 no 2820 0.146411168837298 883 2754130 A steroid.
SGTC_1331 1472-0049 76.2 µM -1.05545655148079 0.169534021847368 no 2821 0.145608285348481 944 24051409
SGTC_3348 9149464 3.537 µM -1.05622787750637 0.169384323766728 no 2822 0.145432058650389 938 1951442
SGTC_741 4582-0002 126 µM -1.06008290843768 0.168637415789949 no 2823 0.144553441340758 932 2912688
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -1.06050676001133 0.168555424386036 no 2824 0.144457058109992 938 2333 A French combination drug.
SGTC_1653 st012112 65 µM -1.06489694377757 0.167707678978126 no 2825 0.14346128411116 947 720429
SGTC_640 3381-0960 37.1 µM -1.06641041033125 0.167416065819532 no 2826 0.143119078886366 946 1745025
SGTC_355 1311-2252 105 µM -1.07240420579979 0.166264399007393 no 2827 0.141769259855658 964 5338538
SGTC_2544 sphondin 68.51 µM -1.07329629421012 0.166093428799099 no 2828 0.14156909868712 932 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -1.07673008332508 0.165436397957267 no 2829 0.140800434263602 979 442882
SGTC_3012 9080433 71.4286 µM -1.07787909771727 0.165216918284568 no 2830 0.140543857295837 948 17688859
SGTC_3326 9140064 16.379 µM -1.07795025636969 0.165203332071598 no 2831 0.140527977884801 962 1868434
SGTC_2578 7,8-dihydroxyflavone 64.44 µM -1.08029520445217 0.164756019277402 no 2832 0.140005372262262 930 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_2197 6588183 93.1375 µM -1.08244850850514 0.164345955418634 no 2833 0.139526641831558 935 884136
SGTC_1414 3917-0015 5.4 µM -1.08257073964292 0.164322698229471 no 2834 0.139499500390557 947 6618702
SGTC_1403 3909-7815 62.9 µM -1.08304496111856 0.164232487260124 no 2835 0.139394233440134 926 6615483
SGTC_1458 k015-0034 6.33 µM -1.0840508754713 0.16404123889411 no 2836 0.139171121049337 966 3598957
SGTC_422 cantharidin 155 µM -1.08423798405283 0.16400568102256 no 2837 0.139129647079691 962 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_514 4466-0038 2.65 nM -1.08537850882198 0.163789045326201 no 2838 0.138877023445333 910 5722064
SGTC_1434 4073-0095 163 µM -1.08638169260524 0.163598650309553 no 2839 0.138655078871679 943 24133745
SGTC_1547 harmine 94.2 µM -1.09249101021099 0.162442262081405 no 2840 0.137308669859178 943 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_3159 9100096 49.47 µM -1.09788097895244 0.161426461954629 no 2841 0.13612823238289 953 25236875
SGTC_1467 k284-1082 293 µM -1.09896868783967 0.161221974390482 no 2842 0.135890861993793 953 3334705
SGTC_3222 9128301 49.47 µM -1.10220703436285 0.16061417127244 no 2843 0.135185837260212 937 4911358
SGTC_2240 6690706 185.951 µM -1.1023379740328 0.160589626814399 no 2844 0.135157383059203 954 805876
SGTC_2157 5649910 96.377 µM -1.10240309627337 0.160577420653756 no 2845 0.135143233022806 955 2858091
SGTC_2418 pentamidine 31.67 µM -1.10493764978877 0.160102828448374 no 2846 0.134593303488 899 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_718 1130-0073 349 µM -1.10502004526941 0.160087415397253 no 2847 0.134575451713253 962 6740020
SGTC_268 camptothecin 39.6153 µM -1.10536252036456 0.160023361769097 no 2848 0.134501268601323 974 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1206 3978-0017 132 µM -1.10572071041006 0.159956386883194 no 2849 0.134423711532661 945 3873677
SGTC_2991 9074669 71.4286 µM -1.10657950884132 0.159795882207054 no 2850 0.134237885360123 952 17333109
SGTC_2918 7977171 22.06 µM -1.11098383106256 0.158974395110087 no 2851 0.133287654546165 934 2236483
SGTC_1272 0839-0021 27 µM -1.11149993779887 0.158878313171104 no 2852 0.133176608404683 984 5027250
SGTC_1537 2',6'-dihydroxyflavanone 78 µM -1.11192824671578 0.158798605175213 no 2853 0.133084501301879 976 5106787 A p450 inhibitor.
SGTC_840 0245-0196 390 µM -1.11215831509454 0.158755800431192 no 2854 0.133035043594812 952 3827528
SGTC_2941 9056145 11.23 µM -1.11398779623317 0.158415690553322 no 2855 0.132642211075579 948 2119517
SGTC_2904 7225135 42.03 µM -1.11656369176603 0.157937629299116 no 2856 0.132090461611394 979 4446116
SGTC_3019 9081971 49.47 µM -1.11843150746062 0.157591573886146 no 2857 0.13169137198878 968 16451803
SGTC_418 lividomycin a 100 µM -1.12129950016535 0.157061183409073 no 2858 0.131080199124998 948 72394 An antibiotic.
SGTC_393 acivicin 6.25 µM -1.12426811596116 0.156513422302276 no 2859 0.130449650115328 929 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_2517 totarol 10 µM -1.12448377002054 0.156473679453362 no 2860 0.130403925975441 945 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_1405 3909-7894 12 µM -1.12768384097702 0.155884719916552 no 2861 0.129726732188821 925 7104060
SGTC_950 1165-0508 94.1 µM -1.12769709238282 0.155882284093639 no 2862 0.129723933020856 963 6148369
SGTC_605 1315-0399 119 µM -1.12831027060036 0.155769599454095 no 2863 0.129594453731306 956 24020461
SGTC_2493 resveratrol 26.09 µM -1.12982607996343 0.155491267560299 no 2864 0.129274758279595 927 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_3288 9119690 36.221 µM -1.13028439068231 0.155407177494923 no 2865 0.129178204859491 987 17595618 YKL019W RAM2
SGTC_2223 6903751 107.57 µM -1.13216503564759 0.155062434236295 no 2866 0.128782528384182 945 5598863
SGTC_524 r073-0010 27.8 µM -1.13228790039877 0.155039929339076 no 2867 0.128756707664813 967 2772106
SGTC_638 3970-0837 4.09 µM -1.13252867795223 0.154995832838534 no 2868 0.128706117322568 945 4118451 YLR208W SEC13
SGTC_3111 9122088 49.47 µM -1.13484309620438 0.154572387951614 no 2869 0.128220532820048 929 16876704
SGTC_156 3474-0145 5.642 µM -1.13666416476674 0.154239744078174 no 2870 0.127839352676065 926 2265471
SGTC_2636 apigenin dimethyl ether 100 µM -1.1375773898049 0.154073109005852 no 2871 0.127648496149064 973 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_869 0564-0080 44.1 µM -1.13766510495894 0.154057109998839 no 2872 0.127630174834835 952 6843321
SGTC_2149 5554786 194.827 µM -1.13837835770027 0.153927055433832 no 2873 0.127481263572149 978 745063 YPR165W RHO1
SGTC_2333 9017922 200 µM -1.14093205567114 0.153462009833277 no 2874 0.126949099246082 947 3163164
SGTC_2666 tannic acid 100 µM -1.14392819683659 0.152917579965093 no 2875 0.126326708100977 943 16134267 A thiamine antagonist.
SGTC_376 3970-0862 59.1 µM -1.14404020043215 0.152897252614425 no 2876 0.126303482793642 957 3135186
SGTC_1655 st012546 55.1 µM -1.15828560976393 0.150326479927437 no 2877 0.123373750938384 975 720985 YLR208W SEC13
SGTC_2815 7968870 71.43 µM -1.16056955286743 0.149917007032733 no 2878 0.122908496682485 976 2977326 YHR190W ERG9
SGTC_705 1124-0212 310 µM -1.16149604992913 0.149751113831519 no 2879 0.122720114314307 941 9554485
SGTC_916 4466-0038 42 nM -1.16180969684792 0.149694981785498 no 2880 0.122656387166125 983 5722064 YGL116W CDC20
SGTC_2747 doxorubicin 7.63 µM -1.1622393743671 0.149618107029993 no 2881 0.122569122474635 900 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_772 k072-0172 35.3 µM -1.16247973687493 0.149575114621868 no 2882 0.122520325425993 931 5861980
SGTC_659 k018-0002 107 µM -1.16345164462513 0.149401358538756 no 2883 0.122323153163707 982 6797879 YHR007C ERG11
SGTC_1135 dihydrocapsaicin 536.708 nM -1.17070882746735 0.148108191634395 no 2884 0.120857917872461 976 107982 A Capsaicinoid.
SGTC_2479 5617353 43.85 µM -1.17224500444352 0.147835421720485 no 2885 0.120549352246396 958 2731746
SGTC_1304 1165-0502 251 µM -1.17485832222385 0.147372163497055 no 2886 0.12002570110907 964 767425
SGTC_906 1165-0455 526 µM -1.17563143297271 0.147235302187667 no 2887 0.119871094555626 968 3252859
SGTC_2695 st077686 51.995 µM -1.17686114566426 0.147017785687292 no 2888 0.119625466195759 973 2876092
SGTC_337 1315-0038 354 µM -1.17731935971401 0.146936790088485 no 2889 0.11953403130239 964 1626437
SGTC_2935 9038016 29.96 µM -1.17748294534428 0.146907881342276 no 2890 0.119501400349403 957 6463195
SGTC_2160 5660466 132.927 µM -1.17776253790953 0.146858480758439 no 2891 0.119445643669246 980 2859134
SGTC_1685 st024049 53.0905 µM -1.1811219236267 0.146265789741808 no 2892 0.118777145888486 970 1941139
SGTC_1726 st035556 14.5795 µM -1.18129790889526 0.146234785285116 no 2893 0.118742198864153 957 5919439
SGTC_3285 9112818 20.8695 µM -1.18140272029443 0.146216322084052 no 2894 0.118721388945722 964 17017947 YPR165W RHO1
SGTC_3161 9100388 49.47 µM -1.18181393163116 0.146143899687253 no 2895 0.118639769328906 977 25236368
SGTC_2100 5377183 190 µM -1.18426341056052 0.145712997608588 no 2896 0.118154403973693 947 2844202
SGTC_3336 9143619 71.43 µM -1.18907984156786 0.144868204305335 no 2897 0.117204125031217 990 45595730
SGTC_927 2425-1185 123 µM -1.18946841998677 0.144800192406662 no 2898 0.117127695436219 983 730375
SGTC_3089 9117425 49.47 µM -1.19234773251558 0.144296903620145 no 2899 0.116562462779835 988 9401657
SGTC_730 1436-0052 41.2 µM -1.19589714521616 0.143678109311449 no 2900 0.115868349674508 960 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_1219 1469-0211 33.1 µM -1.19867833810065 0.143194497318854 no 2901 0.11532652208617 974 6822282
SGTC_769 0302-0231 76 µM -1.19969973257478 0.143017166936883 no 2902 0.115127988473588 992 571869 YER009W NTF2
SGTC_1992 st073643 23.3 µM -1.19973892122852 0.143010366118198 no 2903 0.115120376020316 985 3161292
SGTC_2794 7785382 27.27 µM -1.19993076272965 0.14297707700075 no 2904 0.115083115692634 959 2205081
SGTC_1498 4478-3555 97.6 µM -1.2005265734591 0.142873722886105 no 2905 0.114967449303247 973 3437919
SGTC_1464 k208-0027 110 µM -1.20627846941013 0.141878549714661 no 2906 0.113855068260595 944 X1464
SGTC_760 0568-0725 82.9 µM -1.2147800751886 0.140416245590587 no 2907 0.112224991070593 984 3916171
SGTC_1481 3346-2004 36 µM -1.22295892298583 0.139019147158969 no 2908 0.110672605730491 991 2770522
SGTC_2396 5342950 42.78 µM -1.2235527772813 0.138918075652444 no 2909 0.110560491526294 949 1886677
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -1.22614877227565 0.138476835710808 no 2910 0.110071347466627 975 6708760
SGTC_1540 guanosine 70.6 µM -1.22891107032289 0.138008379161354 no 2911 0.1095525751907 965 6802 Guanosine is a purine nucleoside
SGTC_1731 st035964 63 µM -1.23250382898022 0.137400704108916 no 2912 0.108880468600113 990 6739575
SGTC_2084 5306078 60.6385 µM -1.23446095878853 0.13707044727002 no 2913 0.108515593013289 984 679340
SGTC_1376 2910-0861 41.3 µM -1.23861699378604 0.136370934986495 no 2914 0.107743685840157 996 1112859
SGTC_1198 1612-1005 86.7 µM -1.24539279070812 0.135235728615929 no 2915 0.106493701010125 991 6998509
SGTC_2200 6600604 21.907 µM -1.24593650561512 0.135144917087491 no 2916 0.106393853281949 1000 2904777
SGTC_1104 tacrolimus 29.8 µM -1.24649683355035 0.135051374601079 no 2917 0.106291025487427 951 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_3269 9137823 49.47 µM -1.24844043349816 0.134727249559899 no 2918 0.105934904781775 944 17682936
SGTC_3236 9132701 49.47 µM -1.24941512048959 0.134564906716544 no 2919 0.105756640428754 1009 24282524
SGTC_3153 9100258 49.47 µM -1.24973640344544 0.134511423601583 no 2920 0.105697927268667 981 25236848
SGTC_3197 9113331 49.47 µM -1.25154627998369 0.134210410945012 no 2921 0.105367619922841 969 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_1314 1222-0010 41.1 µM -1.26005567832422 0.132801359781421 no 2922 0.103824638709464 997 3526027
SGTC_1729 st035615 45.989 µM -1.26036195886221 0.132750834158958 no 2923 0.103769409067092 961 17385451
SGTC_3204 9114183 49.47 µM -1.26141136390452 0.132577819271028 no 2924 0.103580338075085 963 17027248
SGTC_1643 st009866 20.2 µM -1.26754374750672 0.131569882967954 no 2925 0.102480465670468 953 3156273 YOR207C RET1
SGTC_1511 0906-3109 28.5 µM -1.26779143919875 0.131529283073817 no 2926 0.102436220080699 992 2882180
SGTC_1555 citronellol 128 µM -1.27130857078248 0.13095371253924 no 2927 0.101809447214633 997 8842 A terpine precursor.
SGTC_1968 st069590 43.6 µM -1.27239619478755 0.130776078197123 no 2928 0.10161619270179 978 6384066
SGTC_1366 1683-0113 21.9 µM -1.27295353152129 0.130685116692211 no 2929 0.10151726587759 1001 708623
SGTC_483 fpl-64176 144 µM -1.27331354189356 0.130626383575797 no 2930 0.101453401622801 999 3423
SGTC_1906 st060206 94.7 µM -1.2766096315883 0.130089498548103 no 2931 0.100870049883993 974 5133468
SGTC_2880 9042983 58.44 µM -1.27772557877985 0.129908073535875 no 2932 0.100673101481906 999 6464714
SGTC_1175 0741-0056 27.6 µM -1.28031422024034 0.12948790006575 no 2933 0.100217324243848 994 765927
SGTC_3249 9135183 49.47 µM -1.28088592285594 0.129395231647533 no 2934 0.100116869013681 953 4902779
SGTC_2227 7312221 64.1025 µM -1.28215747311612 0.129189288331835 no 2935 0.0998937055126698 1017 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_2951 9072950 58.06 µM -1.283474731398 0.1289761817727 no 2936 0.0996629033895181 972 16488155
SGTC_2133 5320837 200 µM -1.29029501624853 0.127876692846045 no 2937 0.0984741233111672 1009 2841355
SGTC_560 2332-1943 155 µM -1.29331878631639 0.127391324791208 no 2938 0.0979504128978991 975 21177716
SGTC_1558 st069300 45.6 µM -1.29397652417648 0.127285916235523 no 2939 0.0978367649136112 974 24208000
SGTC_2594 a-mangostin 100 µM -1.29578754434917 0.126995997126405 no 2940 0.0975243452327967 1007 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_1006 4099-6547 255 µM -1.29675544475565 0.126841238348746 no 2941 0.0973576727350421 1003 3146833
SGTC_2524 avocatin b 10.57 µM -1.29835217297632 0.12658622257421 no 2942 0.0970831729306019 992 6710748
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -1.29863575640574 0.126540968424821 no 2943 0.0970344804534698 979 756377
SGTC_663 1486-0733 13.9 µM -1.29891675658453 0.126496137626729 no 2944 0.0969862492159512 997 722445 YPR165W RHO1
SGTC_383 2324-0395 7.37 µM -1.29893331828803 0.126493495716127 no 2945 0.0969834070928252 917 3146421
SGTC_1203 3992-3522 103 µM -1.29989026065854 0.126340910253531 no 2946 0.0968192918035091 1004 5322312
SGTC_1888 azatryptophan 97.5 µM -1.30062290109308 0.126224176689134 no 2947 0.0966937821173415 988 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_287 k060-0039 29.6 µM -1.30583801378347 0.125395410783214 no 2948 0.0958038248727846 982 5861974
SGTC_1709 st033179 39.1045 µM -1.30748593006775 0.125134321697763 no 2949 0.0955238651618764 987 573381
SGTC_726 3448-4391 34.2 µM -1.31092401440005 0.124590828614344 no 2950 0.0949417183302637 995 1356692
SGTC_1112 tnp00069 1.16933 µM -1.31205548302141 0.124412327237962 no 2951 0.0947507074182251 991 145826
SGTC_2830 7992007 71.43 µM -1.31509042282485 0.123934416169261 no 2952 0.0942397574565395 984 1952075
SGTC_2170 morpholine 200 µM -1.31865985993716 0.123373983987088 no 2953 0.09364142593854 1003 121171 Reacts with secondary amines.
SGTC_3219 9131112 49.47 µM -1.32570106685139 0.122273665525104 no 2954 0.0924693669568209 963 17612988 YMR079W SEC14
SGTC_1877 wortmannin 25 µM -1.32720843330767 0.122039009691236 no 2955 0.0922198717322152 998 312145 A covalent inhibitor of PI 3-kinase.
SGTC_2089 5281248 129.67 µM -1.32988774956862 0.121622694276673 no 2956 0.0917776291347981 991 2737878
SGTC_1066 ketoconazole 628 nM -1.33067237199268 0.121500967853994 no 2957 0.0916484187998386 995 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_3077 9117319 49.47 µM -1.33208937295428 0.121281351189096 no 2958 0.0914154109983144 1014 17154678
SGTC_265 mycophenolic acid 32.932 µM -1.33567089414547 0.120727507049837 no 2959 0.0908284333854853 1019 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_2561 acetosyringone 100 µM -1.33619916945696 0.120645965805748 no 2960 0.090742091239713 999 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_2096 5468907 200 µM -1.34002523455823 0.120056555805926 no 2961 0.0901185705287979 1008 759785
SGTC_1483 3453-0561 55.9 µM -1.34376266891059 0.119482761785825 no 2962 0.0895125724008256 999 4546991
SGTC_2363 9053361 176 µM -1.34870694756256 0.118726662197365 no 2963 0.0887155565442059 1002 6469797 YMR079W SEC14
SGTC_3007 9078383 71.4286 µM -1.3489187014199 0.118694355574376 no 2964 0.0886815403061521 1005 6496995
SGTC_1733 st037357 54.9 µM -1.34913585775146 0.118661231163834 no 2965 0.0886466663020348 995 1272339 YGL099W LSG1
SGTC_155 k072-0202 43.6 µM -1.35031735873164 0.118481122796568 no 2966 0.0884571032908071 998 5857737
SGTC_60 0986-0278 202 µM -1.35122916143719 0.118342259468713 no 2967 0.088311017956822 1005 3110598
SGTC_1244 0416-0015 52.5 µM -1.35522979225682 0.117734341928376 no 2968 0.0876721777566054 1000 96201
SGTC_1350 1495-0454 146 µM -1.35524699630382 0.117731732461511 no 2969 0.0876694379959601 998 1069057
SGTC_808 0711-0032 135 µM -1.3592229913705 0.117129760921898 no 2970 0.0870379689434816 991 4252555
SGTC_2966 9084041 48.03 µM -1.35955195896049 0.117080052595439 no 2971 0.0869858747469271 1000 17741380
SGTC_76 0433-0009 400.328 µM -1.36337973966805 0.116502758130021 no 2972 0.0863814314748163 1042 2841569
SGTC_1920 st075728 45.7 µM -1.36368505470613 0.116456798520929 no 2973 0.0863333548866406 988 3400306
SGTC_1117 retinoic acid 1.10837 µM -1.36575342170121 0.116145782268408 no 2974 0.0860081852501376 1021 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_1514 1189-1591 158 µM -1.36638448923116 0.116051007368809 no 2975 0.0859091572972226 1012 767698 YMR146C TIF34
SGTC_2143 5623677 140.463 µM -1.37243189666645 0.115145579338401 no 2976 0.0849645131080764 965 5375313
SGTC_1852 st056254 31.4 µM -1.37707587548555 0.114453692584498 no 2977 0.084244395225249 1002 442583
SGTC_410 α-linolenic acid 100 µM -1.37880946445239 0.114196172628882 no 2978 0.0839767539217173 1010 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1432 4049-0298 68.4 µM -1.37944961356153 0.11410118461108 no 2979 0.0838780856461677 1018 741646
SGTC_1399 3562-5772 25 µM -1.38589756815929 0.113147547445404 no 2980 0.0828890917501289 995 23847490
SGTC_846 0335-0850 148 µM -1.38749011056406 0.112912892489109 no 2981 0.0826461823154327 998 6819598
SGTC_1813 st051246 8.6015 µM -1.38838953867461 0.112780518839088 no 2982 0.0825092300896256 1003 5291959
SGTC_649 1123-0311 367 µM -1.38921080402863 0.11265974563123 no 2983 0.0823843286678407 990 693629 YIL048W NEO1
SGTC_2934 9036370 36.88 µM -1.39481414970816 0.111838196192575 no 2984 0.0815359454286254 979 6462800
SGTC_795 0685-0265 78 µM -1.39674662875337 0.111555856731612 no 2985 0.0812448884345575 999 302754
SGTC_1114 scopoletin 1.73284 µM -1.39723406960817 0.111484721162074 no 2986 0.0811715973173144 1018 5280460 A coumarin with genotoxic properties.
SGTC_1271 0832-2808 169 µM -1.39990326277745 0.111095763141656 no 2987 0.0807711444337726 1009 3663794
SGTC_1170 0310-0127 64.8 µM -1.40024640448288 0.111045830704923 no 2988 0.0807197720781789 1015 774975
SGTC_83 0170-0301 39.027 µM -1.40292880395074 0.110656053859318 no 2989 0.0803190352806415 1030 3089716
SGTC_1654 st012436 41.8 µM -1.40753804156691 0.109988581853936 no 2990 0.0796339525609915 1033 4323132
SGTC_309 k408-0051 1.48 µM -1.40946808946781 0.109709947952095 no 2991 0.0793484013810046 987 3640463
SGTC_1421 4029-0249 71.4 µM -1.41413416725703 0.109038417766653 no 2992 0.0786612564179982 1010 2894095
SGTC_1673 st016611 27.3 µM -1.4149322558127 0.108923855367284 no 2993 0.0785441797557165 1032 5226799
SGTC_2507 purpurin 79.67 µM -1.41724986944063 0.108591661809802 no 2994 0.0782049430639353 1013 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_1605 st000082 49.1 µM -1.41823422522549 0.108450790557417 no 2995 0.0780611963740007 978 1114022
SGTC_3034 9090421 49.47 µM -1.41920071821036 0.108312603623733 no 2996 0.0779202533231286 995 17173761
SGTC_12 0849-0099 9.267 µM -1.42172703995427 0.107951994587695 no 2997 0.07755275359119 995 6071388
SGTC_1844 rapamycin 4 nM -1.42223699388853 0.107879308378728 no 2998 0.0774787313617219 954 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_2778 tioconazole 65.09 nM -1.42261328625418 0.107825696206835 no 2999 0.0774241451541241 988 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1404 3909-7820 48.3 µM -1.42291358430574 0.107782925078528 no 3000 0.0773806038912234 965 23741373
SGTC_1649 st011737 51.3 µM -1.42458830822383 0.107544620068474 no 3001 0.0771381208405088 955 1761035
SGTC_2681 menadione 3.18 µM -1.4259258961691 0.107354560765812 no 3002 0.0769448667469245 1017 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_425 3825-7017 13.1 µM -1.42608826933775 0.107331505479168 no 3003 0.0769214322171913 1007 3397440
SGTC_570 0987-0065 62.6 µM -1.42666498517452 0.107249646733874 no 3004 0.0768382414807316 976 3104428
SGTC_2104 5389443 200 µM -1.42717248580935 0.1071776496005 no 3005 0.0767650915704567 1029 2244536
SGTC_902 1120-0002 2.07 µM -1.42721155071756 0.107172109059479 no 3006 0.0767594630449181 951 3280475
SGTC_1519 esterone 74 µM -1.42897131467455 0.106922737481185 no 3007 0.076506239165951 1022 698 A steroid.
SGTC_1017 4239-0030 168 µM -1.43037274320274 0.106724444313639 no 3008 0.0763050334454548 1008 1149593
SGTC_2362 9071156 126 µM -1.43259772344955 0.106410169229871 no 3009 0.0759864163629908 1015 653133
SGTC_2471 5466956 24.79 µM -1.43280270316195 0.106381249809159 no 3010 0.0759571143115578 997 724419
SGTC_3073 9114972 49.47 µM -1.43450069141358 0.10614190852159 no 3011 0.0757147159616377 1007 41905075
SGTC_822 1487-0950 154 µM -1.43660848215791 0.105845344671509 no 3012 0.0754146360489864 991 1958375
SGTC_2969 9091408 28.7 µM -1.43763484527586 0.105701153518704 no 3013 0.0752688443250792 1003 4286311
SGTC_1937 st074714 47.2 µM -1.45053699073929 0.103900664958384 no 3014 0.0734544158321227 1013 17250970
SGTC_1265 0819-1001 68.8 µM -1.45092591851381 0.103846737768 no 3015 0.0734002449110016 1019 3106768
SGTC_727 3032-0951 202 µM -1.45336581865376 0.103508893970075 no 3016 0.0730611058199938 1019 3652836
SGTC_1026 k007-1105 30.6 µM -1.45457251370391 0.103342102562319 no 3017 0.0728938224995761 1002 7066794
SGTC_945 3381-0768 11.3 µM -1.46286915678983 0.102200607033988 no 3018 0.0717515925480981 1028 1126236 YIL048W NEO1
SGTC_95 0471-0001 561.058 µM -1.46480007613282 0.101936261789021 no 3019 0.0714877355548442 1005 4015405
SGTC_601 0986-0029 62.9 µM -1.46536198664684 0.101859429099 no 3020 0.0714110914358368 990 24747981
SGTC_2623 humulene 100 µM -1.4700937244932 0.101214107569306 no 3021 0.0707681858767923 1019 6187145 An anti-inflammatory.
SGTC_2887 9044784 58.44 µM -1.47427059211551 0.10064694011613 no 3022 0.0702043749079565 1006 6465546
SGTC_507 nimesulide 162 µM -1.47533178171522 0.100503213581209 no 3023 0.0700616829633289 1021 4495 A COX2 inhibitor.
SGTC_2738 aclarubicin 5.55 µM -1.47938240777474 0.099955977240591 no 3024 0.0695190696080991 1040 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_1342 1486-1464 234 µM -1.47978048586549 0.0999023148709885 no 3025 0.0694659190269049 1011 3253938
SGTC_2206 7254556 146.969 µM -1.48827164567543 0.0987626823359506 no 3026 0.0683396347131169 1016 4398905
SGTC_844 0330-0132 15.3 µM -1.49307733666904 0.0981219222865228 no 3027 0.067708472096582 1018 2828079
SGTC_1561 5-methoxyflavone 52.9 µM -1.50128221832791 0.0970349840098357 no 3028 0.0666412910803499 997 94525
SGTC_998 3996-0085 177 µM -1.5017768196502 0.0969697454796067 no 3029 0.0665773783822519 1027 715391
SGTC_3181 9108277 49.47 µM -1.5025598231824 0.096866532183657 no 3030 0.0664762951890297 1027 17097298
SGTC_1482 3346-2049 8.48 µM -1.50323952479311 0.0967770012744571 no 3031 0.0663886443073798 1023 3826804
SGTC_3245 9134821 49.47 µM -1.50444837477533 0.0966179206367747 no 3032 0.0662329782601589 1022 17014901
SGTC_2735 sertaconazole 140 nM -1.50764775800444 0.0961978195246832 no 3033 0.0658223513882758 1060 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_1177 0983-0204 23.6 µM -1.51009955353086 0.095876791758514 no 3034 0.0655090117103514 1009 766818
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -1.51027673453937 0.0958536229902101 no 3035 0.0654864128560526 1005 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_1386 3228-0095 33.8 µM -1.51107899211076 0.0957487687022899 no 3036 0.0653841632016034 1016 870181
SGTC_1525 8-methoxypsoralen 92.5 µM -1.511608323768 0.0956796317873962 no 3037 0.0653167664485624 1045 4114 Related to psoralen; DNA damaging agent.
SGTC_3271 9137798 49.47 µM -1.51303507574868 0.0954934642041954 no 3038 0.0651353747248991 975 6498326
SGTC_2810 7959871 45.46 µM -1.51803063234748 0.0948437275113723 no 3039 0.0645033383071657 1009 2974535
SGTC_1426 4048-4480 71.7 µM -1.5194586423131 0.0946585963991261 no 3040 0.0643235453298967 1025 14224343
SGTC_2118 5526350 200 µM -1.51965915645834 0.0946326225382513 no 3041 0.0642983308951298 1024 743594
SGTC_968 1309-0633 340 µM -1.52059941367037 0.0945108951697322 no 3042 0.0641801970265307 1024 3761976
SGTC_2349 9023730 187.07 µM -1.52352286641964 0.0941331572821191 no 3043 0.0638139721638149 1039 4126287
SGTC_3315 9136395 68.55 µM -1.52729236838284 0.0936477472651874 no 3044 0.0633441631684732 1027 16876844
SGTC_1161 k007-0610 110 µM -1.53196991383745 0.0930479785730554 no 3045 0.062764929626607 1001 5843850
SGTC_2799 7812892 81.82 µM -1.53337200923402 0.0928687520306792 no 3046 0.0625921106709205 1001 20205235
SGTC_1447 4239-0816 81.9 µM -1.5343958434139 0.0927380390603591 no 3047 0.0624661497843219 1018 1341554
SGTC_261 5-fluorouridine 15.376 µM -1.53619907892537 0.0925081508091938 no 3048 0.0622447809286981 1030 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2689 tacrolimus 100 µM -1.54260816100388 0.0916944912603946 no 3049 0.0614629383636906 1000 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_71 0417-1750 47.813 µM -1.54273479677455 0.0916784679138087 no 3050 0.0614475677291606 989 6811472
SGTC_806 3966-4455 5.86 µM -1.54721102525209 0.0911134182682984 no 3051 0.060906184126409 1024 714982
SGTC_1787 fluconazole 80 µM -1.55715768160158 0.089867071291045 no 3052 0.0597165264579661 991 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_2211 7117706 200 µM -1.55819597844949 0.0897377034449667 no 3053 0.0595933990100372 1017 822771
SGTC_2110 5483698 200 µM -1.5598966657493 0.089526103446922 no 3054 0.0593921512744841 1020 2848765 YHR062C RPP1
SGTC_2913 7966556 36.57 µM -1.56267903917731 0.0891807202256207 no 3055 0.0590640535039289 989 2976516
SGTC_1359 1582-0056 520 nM -1.5657666225251 0.0887986122317892 no 3056 0.0587016314291672 1037 3661189
SGTC_1516 st013856 110 µM -1.56953185516941 0.0883342922842045 no 3057 0.0582620314437405 1032 5281404 A mutagen and neurotoxin.
SGTC_2432 5630864 12.22 µM -1.57019490469862 0.0882527142248616 no 3058 0.0581848872998917 1030 5714970
SGTC_2875 9039966 71.43 µM -1.57137449259621 0.0881077228836088 no 3059 0.0580478436230281 1034 6463691
SGTC_1994 st072947 40.9 µM -1.57427792954758 0.0877515979110136 no 3060 0.0577116049281334 1034 5286565 YDL195W SEC31
SGTC_249 wiskostatin 11.211 µM -1.57898584127192 0.0871764265476575 no 3061 0.0571696523486173 1006 2775510 A n-wasp and actin depolymerizer.
SGTC_477 mead ethanolamide 10 µM -1.58082032309009 0.0869530694590941 no 3062 0.0569595631628415 1045 16061185
SGTC_2435 5706476 10.6 µM -1.58711179631948 0.0861902988987723 no 3063 0.0562436633318735 1013 5725375
SGTC_1042 0350-0096 82 µM -1.58738798954418 0.0861569286171176 no 3064 0.0562123989005929 1031 3122515
SGTC_446 go6976 132 µM -1.58751797358923 0.086141226999758 no 3065 0.0561976897513728 1043 3501 A protein kinase C inhibitor.
SGTC_2219 9098279 200 µM -1.58849725401991 0.0860230021608944 no 3066 0.0560869707486745 1037 902349
SGTC_3174 9107204 49.47 µM -1.59068663006148 0.085759126227501 no 3067 0.0558400586567047 1041 3938802
SGTC_352 k048-0007 5.11 µM -1.59368058092009 0.0853992598738214 no 3068 0.0555037979153765 1019 6811911
SGTC_2420 aureobasidin a 50 nM -1.59434282173948 0.0853198129605237 no 3069 0.0554296357508355 1030 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_3257 9139206 32.98 µM -1.59440133895306 0.0853127955008316 no 3070 0.0554230863651173 1034 4910041
SGTC_662 k832-1615 104 µM -1.5987565217257 0.0847917291749121 no 3071 0.0549373566111188 1046 5878478
SGTC_3114 9122766 49.47 µM -1.60254100701692 0.0843408836266287 no 3072 0.0545180135545447 1001 17176985
SGTC_1876 myriocin 605 nM -1.60317107079769 0.0842659991579109 no 3073 0.0544484452683343 1029 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_3024 9090631 49.47 µM -1.60386765585024 0.0841832665826142 no 3074 0.0543716138058327 1014 25236383
SGTC_3280 9140961 49.47 µM -1.60518661615496 0.0840267822841098 no 3075 0.0542263709842884 1049 4901226
SGTC_2621 lithochol-11-enic acid 100 µM -1.60976929463457 0.0834847809367616 no 3076 0.0537241154154852 1037 6708711
SGTC_128 0906-2981 13.371 µM -1.61197243429111 0.0832251488602895 no 3077 0.0534839691788841 1035 6740226
SGTC_2671 danthron 100 µM -1.61252034137374 0.0831606743457773 no 3078 0.0534243785698804 1036 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_3345 9148410 3.559 µM -1.61796270911532 0.0825222863068922 no 3079 0.0528353172116083 1005 4903596
SGTC_2795 7780010 54.55 µM -1.62342889343874 0.0818848250228708 no 3080 0.0522488761686576 1015 953673
SGTC_1880 MG-132 525 µM -1.63360271980485 0.0807082549921059 no 3081 0.051171148186117 1012 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_2268 7933382 153.85 µM -1.63363821733347 0.080704172286624 no 3082 0.051167419087202 1015 935025 YOR257W CDC31
SGTC_3316 9136639 10.545 µM -1.63406505293457 0.080655092516285 no 3083 0.0511225959336338 1010 4903665
SGTC_3311 9131146 2.8755 µM -1.63461668972253 0.0805916958545923 no 3084 0.0510647133647903 1048 4900406 YPR165W RHO1
SGTC_1280 0880-0253 10.1 µM -1.63574766723942 0.0804618363643625 no 3085 0.0509462043804944 1030 6836607
SGTC_3001 9076041 71.4286 µM -1.63938754933653 0.0800449760279902 no 3086 0.0505662864988431 1035 16004211
SGTC_2752 diclazuril 33.15 µM -1.64003220255196 0.079971317121404 no 3087 0.0504992357499308 1016 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_2444 5485484 36.41 µM -1.64037588221693 0.0799320687915303 no 3088 0.0504635183900479 1050 6790631
SGTC_2786 7743617 45.45 µM -1.64576099827137 0.0793189875012089 no 3089 0.0499064874914416 1035 583674
SGTC_374 0880-0231 82.3 µM -1.64624473284049 0.079264090311769 no 3090 0.0498566914689042 1007 6833587
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -1.64650212083948 0.0792348920572262 no 3091 0.0498302119010473 1048 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_293 4049-0273 38.5 µM -1.64929598092729 0.0789184785629334 no 3092 0.0495435063179296 1027 1380311
SGTC_1596 piperlongumine 63 µM -1.6494049954814 0.0789061517505934 no 3093 0.0495323460010765 1022 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_2184 6075246 200 µM -1.65040503830092 0.0787931400382008 no 3094 0.0494300606615789 1037 2267320
SGTC_1980 st071811 45.7 µM -1.65492484475415 0.0782839000885124 no 3095 0.0489698719316397 1040 4974850
SGTC_1033 k072-0102 21.3 µM -1.66292571433545 0.0773885791721377 no 3096 0.0481636531791672 1023 5965931
SGTC_296 1222-0039 74.9 µM -1.67235927072141 0.0763429523885925 no 3097 0.0472267492289533 1048 5984176
SGTC_1664 st014217 9.02 µM -1.67503409469665 0.0760484367162486 no 3098 0.0469637711800543 1012 3982782
SGTC_3175 9106517 49.47 µM -1.67556365473056 0.0759902313943466 no 3099 0.0469118464658771 1051 41468073
SGTC_1295 1013-0063 9.78 µM -1.68459958182667 0.0750022887941288 no 3100 0.0460329260494286 1047 6826038
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -1.68704600887743 0.0747365013584122 no 3101 0.0457972527385789 1031 688664
SGTC_2931 9014674 55.67 µM -1.68999362875687 0.0744172181314711 no 3102 0.0455145867775365 1047 2996810
SGTC_2198 6589944 200 µM -1.69436972092963 0.0739451263427726 no 3103 0.0450975247530577 1033 5290268
SGTC_1803 st050068 52.4 µM -1.696339634112 0.0737333609719031 no 3104 0.0449107893273122 1025 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_3232 9132874 49.47 µM -1.69866629740399 0.073483842480657 no 3105 0.0446910385248076 1037 3784940
SGTC_1810 st050138 53 µM -1.70106097955416 0.0732277042822028 no 3106 0.0444657685635753 1048 3444541
SGTC_2017 5132927 60.65 µM -1.70265397409261 0.0730576942873891 no 3107 0.0443164214656614 1041 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_2457 5731572 11.68 µM -1.70369068912777 0.0729472147684825 no 3108 0.044219444262739 1042 2865357
SGTC_3010 9080089 71.4286 µM -1.70969842752955 0.0723095048618478 no 3109 0.0436608268436297 1043 17027233
SGTC_2776 terbinafine 19.92 µM -1.71145095806085 0.0721242843028526 no 3110 0.0434989485362732 1016 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2965 9082772 38.63 µM -1.71378160897159 0.0718785273444877 no 3111 0.0432844211284936 896 16459634
SGTC_1191 1487-1166 10.6 µM -1.71423460614726 0.0718308353962498 no 3112 0.0432428238194924 1063 3955771
SGTC_197 4544-0043 41.561 µM -1.72191633386508 0.0710257865976227 no 3113 0.0425423378268042 1046 896523
SGTC_1081 sertraline 6 µM -1.72486399688663 0.0707187163232062 no 3114 0.0422759926064393 1034 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_1941 st076221 61.8 µM -1.73075427371605 0.070108159089718 no 3115 0.0417478003136583 1010 2828568
SGTC_1286 0929-0070 131 µM -1.73975474928009 0.0691830564559849 no 3116 0.0409510456230203 1049 1420408
SGTC_1143 3454-2408 5.08 µM -1.74059454276267 0.0690972213396875 no 3117 0.0408773374539982 1000 X1143
SGTC_1679 SEC14.276 6.7 µM -1.74063406808333 0.0690931834879948 no 3118 0.0408738709940595 1024 1005053 YMR079W SEC14
SGTC_1875 nocodazole 6 µM -1.74988831944751 0.068152777909151 no 3119 0.0400687933040782 1045 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_2667 digitoxin 100 µM -1.75078037632085 0.0680626528245034 no 3120 0.0399918740471439 1034 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_1741 st038134 10.228 µM -1.75717231192496 0.0674195607916106 no 3121 0.0394442215772692 1053 1272587
SGTC_2640 pentamidine 10.38 µM -1.75733319684982 0.067403434975597 no 3122 0.0394305162829525 982 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2437 5741531 144.16 µM -1.76506128370544 0.0666323389225689 no 3123 0.0387767333089122 1020 2262990
SGTC_3054 9094397 49.47 µM -1.77146358149514 0.0659987138087762 no 3124 0.0382418218058766 1056 2598354
SGTC_1158 4092-0494 91.8 µM -1.77396740561528 0.065752188076858 no 3125 0.0380342709483615 1059 1148199
SGTC_2061 5245884 80.95 µM -1.77455491255404 0.0656944458549454 no 3126 0.037985703757199 1065 573863
SGTC_706 4262-0057 46.9 µM -1.79182059097767 0.0640150081153081 no 3127 0.0365808546687158 1066 883298
SGTC_2616 abietic acid 100 µM -1.79971974083188 0.0632578726718211 no 3128 0.0359524512003032 1053 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_2030 5175110 200 µM -1.7999051593024 0.0632401843826115 no 3129 0.0359378074401638 1057 2831986
SGTC_3310 9130229 44.1445 µM -1.80175202768259 0.06306420959251 no 3130 0.0357922142024722 1058 7761258
SGTC_3322 9139058 2.11 µM -1.80789328817744 0.0624817947575007 no 3131 0.0353115552917293 1055 4908926 YPR165W RHO1
SGTC_1567 st069303 68.4 µM -1.80935455723513 0.0623438328568015 no 3132 0.0351979690966503 1058 5581319
SGTC_2475 5812728 15.03 µM -1.81332782250025 0.061969908442699 no 3133 0.034890637269317 1050 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_2754 granisetron 64.02 µM -1.81621128192446 0.0616996434115152 no 3134 0.0346689840603497 1053 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_863 0466-0191 129 µM -1.81797164441237 0.0615350985791136 no 3135 0.034534233401781 1061 765160 YPR165W RHO1
SGTC_1092 toremifene 6.32 µM -1.82003940740832 0.0613422582887235 no 3136 0.0343765019444153 1062 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2350 9023895 38.85 µM -1.82780689526493 0.0606220749134416 no 3137 0.0337892690100924 1034 2997209
SGTC_2675 theaflavin digallate 100 µM -1.82816542679028 0.0605889930818116 no 3138 0.0337623640308911 1064 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_1704 st028805 70.8 µM -1.83215131785686 0.0602221640405016 no 3139 0.033464439751093 1049 2876101
SGTC_471 1-acyl-paf 4 µM -1.83245046548127 0.0601947032119279 no 3140 0.0334421676376992 1062 16759367
SGTC_1658 st012944 20 µM -1.84175473322875 0.059345484197885 no 3141 0.0327555170722372 1048 24207260
SGTC_612 0302-0167 22.4 µM -1.85255096922284 0.0583718954096576 no 3142 0.0319733728225013 1058 235821
SGTC_1448 4255-0083 152 µM -1.85710327312141 0.0579651541055321 no 3143 0.0316482313185261 1070 5399660
SGTC_3188 9110789 49.47 µM -1.86954986156303 0.0568644375456693 no 3144 0.030773176688853 1046 849217
SGTC_348 k064-0012 10.7 µM -1.87040916278994 0.0567890566956778 no 3145 0.0307135102685743 1049 5066323
SGTC_710 3448-4187 58 µM -1.87519674083013 0.0563705137707732 no 3146 0.0303828311921349 1059 3946412
SGTC_2925 9010536 32.5 µM -1.87921690038207 0.0560209419858615 no 3147 0.0301074414569821 972 2994177
SGTC_1687 st020778 55.3625 µM -1.87944341701648 0.056001296296645 no 3148 0.03009198635873 1074 4259299
SGTC_1619 st003326 88.7 µM -1.8828380543831 0.0557075313420592 no 3149 0.0298611590909415 1016 2849032
SGTC_2779 methotrexate 400 µM -1.89017530030405 0.0550767366016618 no 3150 0.0293672594596726 1025 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_1067 clotrimazole 1.36 µM -1.89040053503267 0.0550574624588804 no 3151 0.0293522059620687 1048 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2571 chrysanthemic acid 100 µM -1.90761424390537 0.0536001252884935 no 3152 0.0282205463883938 1061 2743 An insecticide.
SGTC_465 cgp-37157 41 µM -1.91119763806961 0.0533006275079902 no 3153 0.0279895936533321 1063 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_3078 9116413 49.47 µM -1.91475515347479 0.0530046062863582 no 3154 0.0277618681014431 1047 17177322
SGTC_1057 3448-5381 134 µM -1.91538706104405 0.0529521618143598 no 3155 0.0277215800082702 1006 5497911
SGTC_2318 6029776 164 µM -1.91918812578917 0.0526375644467934 no 3156 0.0274802648662836 1052 818325
SGTC_3300 9124615 50.48 µM -1.9196705528481 0.0525977423800169 no 3157 0.027449763034672 1062 24824903
SGTC_887 0885-0007 9.62 µM -1.91993130089695 0.0525762288206122 no 3158 0.0274332887891167 1081 5719458
SGTC_1363 1636-0063 10.4 µM -1.92134485628258 0.0524597220254291 no 3159 0.0273441227949233 1067 6072185
SGTC_2272 7805186 180 µM -1.92655364411165 0.0520321760910814 no 3160 0.0270176402103631 1061 2956062 YPR165W RHO1
SGTC_641 4092-0595 30 µM -1.93276257521845 0.0515261584777166 no 3161 0.0266327263125885 1070 786260
SGTC_3247 9135149 49.47 µM -1.93343446010967 0.0514716364179001 no 3162 0.0265913497908665 1053 8934436 YOR116C RPO31
SGTC_1215 3852-0577 11.2 µM -1.93421499898449 0.0514083549345531 no 3163 0.0265433495014534 1053 2884876
SGTC_3042 9091578 49.47 µM -1.93608895472051 0.0512566782819221 no 3164 0.0264284035392402 1048 25236497
SGTC_848 0368-0089 85.6 µM -1.9362538894787 0.0512433456440267 no 3165 0.0264183066076693 1058 762535
SGTC_881 0833-0569 170 µM -1.93657012146484 0.0512177904859748 no 3166 0.0263989566191069 1057 5418700
SGTC_833 3852-0053 558 µM -1.93765797564086 0.0511299568687424 no 3167 0.0263324821086353 1076 3123681
SGTC_2009 4012297 12.05 µM -1.93870624544739 0.0510454327447668 no 3168 0.0262685588725739 1043 45595307
SGTC_1919 st067113 52.3 µM -1.94372800062806 0.0506420597799274 no 3169 0.025964130081245 1051 1268243
SGTC_1953 st076800 12.1 µM -1.95361442203552 0.0498553536221769 no 3170 0.0253734168734346 1052 297591
SGTC_2381 9035592 200 µM -1.95577973578458 0.04968435815747 no 3171 0.0252455535086201 1067 4749657
SGTC_2549 cedrol 20.94 µM -1.95793196103501 0.0495148603336424 no 3172 0.0251189984836988 1054 6708665 A sedative which affects the nervous system.
SGTC_266 formosanin C 406 nM -1.95972287281959 0.0493741697153646 no 3173 0.0250140951214021 1039 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_2741 miltefosine 3.04 µM -1.96153098650397 0.0492324516882381 no 3174 0.0249085569931289 1064 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_2645 abamectin 100 µM -1.96190442526057 0.0492032224670612 no 3175 0.0248868062630446 997 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_1174 0739-0097 51.1 µM -1.96762258122558 0.0487573882521284 no 3176 0.0245557397832749 1065 728447
SGTC_1075 aripiprazole 15.2 µM -1.97146021336869 0.0484599898989003 no 3177 0.0243356297876134 1070 60795 An atypical antipschotic. YIL048W NEO1
SGTC_3000 9075062 71.4286 µM -1.98035381302711 0.0477763535261089 no 3178 0.0238318929756667 1034 17057871
SGTC_1230 0170-0365 3.77 µM -1.98649501710534 0.0473088126330424 no 3179 0.0234891927874691 1038 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_2625 euphol 100 µM -1.99481718237819 0.0466810904082568 no 3180 0.0230314113260232 1050 6708538 A triterpene alcohol.
SGTC_302 1094-0063 18.9 µM -2.01023598653544 0.0455357568540516 no 3181 0.0222031091656599 1066 5440289
SGTC_2291 7917025 104.35 µM -2.01256165974193 0.0453649799703859 no 3182 0.022080381921284 1054 2964612
SGTC_1636 st007707 68.9 µM -2.02686567423457 0.0443259177280424 no 3183 0.021338075904412 1065 403051
SGTC_2792 7535235 81.82 µM -2.03597154440147 0.0436745064925597 no 3184 0.0208766063671767 1058 1281891
SGTC_245 methotrexate 289.6 µM -2.03625844524013 0.0436541085252873 no 3185 0.0208622051030733 1061 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_2950 9072895 21.46 µM -2.03871862914531 0.0434795107302147 no 3186 0.0207390587049485 1045 17332245
SGTC_3103 9120822 49.47 µM -2.04019769031455 0.0433748142361995 no 3187 0.0206653198560439 1050 17141819
SGTC_2576 guaiol 23.12 µM -2.04075025649411 0.0433357526732585 no 3188 0.0206378286081062 1055 227829
SGTC_417 st075190 100 µM -2.04673210167136 0.0429147044259894 no 3189 0.0203421977552829 1071 222757
SGTC_445 e6 berbamine 66 µM -2.04865704524687 0.0427799173020812 no 3190 0.0202478311397526 1053 6610268 A calcium/calmodulin antagonist.
SGTC_597 k018-0003 82.8 µM -2.04867942468741 0.0427783522782849 no 3191 0.020246736217452 1075 6786234
SGTC_2939 9044578 71.43 µM -2.05665881775226 0.0422232858096464 no 3192 0.0198595280837003 1070 2653634
SGTC_2415 st077333 57.7 µM -2.06429101875452 0.0416978378352057 no 3193 0.0194950660269804 1054 2766255
SGTC_2824 7998404 51.95 µM -2.06842780820965 0.0414152565185756 no 3194 0.0192999062762821 1068 837851
SGTC_339 3091-4833 71.4 µM -2.06963812951058 0.0413328743681141 no 3195 0.019243122304712 1045 3240077
SGTC_2011 4012611 177 µM -2.07035635696192 0.041284050078695 no 3196 0.0192094928084313 1057 2049887
SGTC_1841 st054148 70 µM -2.07200789840451 0.0411719575007661 no 3197 0.0191323523052217 1075 675442
SGTC_1076 itraconazole 331 nM -2.07460554196036 0.0409961509716335 no 3198 0.0190115540303401 1073 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_2327 6189656 200 µM -2.07727926606176 0.0408158317469384 no 3199 0.0188878957949333 1058 5349088
SGTC_1422 4031-0024 15.5 µM -2.0877708686638 0.0401144725195151 no 3200 0.0184092542834413 1072 782427
SGTC_2758 dehydroepiandrosterone 69.35 µM -2.09392441409019 0.0397076869558773 no 3201 0.0181333570252542 1068 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_1660 st012960 28.1 µM -2.09680925151539 0.0395181403539527 no 3202 0.0180052321487383 1064 24207266
SGTC_3287 9117173 37.0625 µM -2.1034244787915 0.0390862687298839 no 3203 0.0177143402560365 1039 2789709
SGTC_729 4092-0585 94.1 µM -2.10673702897449 0.0388714587346125 no 3204 0.0175701902933518 1060 2169061
SGTC_1711 st032263 62.8 µM -2.11238347561926 0.0385075187164126 no 3205 0.0173267855824282 1067 3958979
SGTC_2447 5741742 33.78 µM -2.12595368099595 0.037644204400207 no 3206 0.0167535582336215 1069 1776504
SGTC_1707 st032323 6.317 µM -2.12628031058651 0.0376236211146091 no 3207 0.0167399632411974 1045 3132057 YMR211W DML1
SGTC_3126 9127922 49.47 µM -2.12807168189277 0.0375108972214795 no 3208 0.0166655703955153 1046 45595682
SGTC_256 clotrimazole 625 nM -2.13101797349393 0.0373260987106728 no 3209 0.0165438307473542 1058 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_2968 9090663 33.37 µM -2.13469974768839 0.037096215042793 no 3210 0.0163927718144519 1038 25236811
SGTC_1505 k297-0037 20.6 µM -2.13482774309342 0.0370882440883053 no 3211 0.0163875416239097 1077 4089396
SGTC_1780 st038448 24.544 µM -2.14010770068049 0.0367606509967386 no 3212 0.0161730319525959 1064 728868 YDL195W SEC31
SGTC_1830 st055982 50.3 µM -2.14189206872022 0.0366504769744324 no 3213 0.0161010841220043 1076 455313 An antimicrobial agent.
SGTC_2328 6201408 200 µM -2.14912591768275 0.0362065940253471 no 3214 0.015812209882335 1060 2890418
SGTC_2651 TUB2.036 5 µM -2.15162097636033 0.0360545170701977 no 3215 0.0157136093212615 1046 15992207 YFL037W TUB2
SGTC_1927 st060202 13.8 µM -2.15927419598626 0.0355913041589404 no 3216 0.0154144504061965 1056 688887
SGTC_1855 st056195 39.6 µM -2.16201646210972 0.0354265196618348 no 3217 0.0153084536589614 1046 4028379
SGTC_547 1120-0019 610 nM -2.18078580453279 0.0343153807446824 no 3218 0.0145996315075375 1024 3676939
SGTC_299 1273-0059 1.44 µM -2.18855618926612 0.0338638372592113 no 3219 0.0143145565275647 1041 2848077
SGTC_951 1171-0579 82.7 µM -2.19087058956832 0.033730294153118 no 3220 0.0142305792855208 1050 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_896 0964-0007 44.5 µM -2.19537084699184 0.0334718654770806 no 3221 0.0140685032924078 1068 6756758
SGTC_737 1950-0117 57.9 µM -2.19616334268996 0.0334265254041183 no 3222 0.0140401270551997 1066 5393513
SGTC_3202 9113761 49.47 µM -2.20326255713114 0.0330226181204985 no 3223 0.0137881242014779 1066 4798415
SGTC_2119 5528445 120.635 µM -2.20646276053912 0.0328418632836806 no 3224 0.0136758074414293 1082 791935
SGTC_500 h-89 112 µM -2.21837491500736 0.0321761918081735 no 3225 0.0132646400215213 1076 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_3209 9113616 49.47 µM -2.23176058489983 0.0314415079423334 no 3226 0.0128153953254498 1069 16649353
SGTC_2566 crystal violet carbinol 226 nM -2.25012623688583 0.0304561131093609 no 3227 0.0122204665092161 1065 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_2744 captopril 92.04 µM -2.25745330005455 0.0300701908283029 no 3228 0.0119898822171989 1077 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_1345 1488-0192 31.4 µM -2.27420653933906 0.0292030018895345 no 3229 0.011476785629708 1076 658348
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -2.28596453388471 0.0286068680576168 no 3230 0.0111281667461597 1065 6728940
SGTC_1588 farnesol 29.9 µM -2.29180167259757 0.0283147037893796 no 3231 0.0109585450630116 1073 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_2539 epi(13)torulosol 80 µM -2.30295032992871 0.0277635838800684 no 3232 0.010640818951636 1044 6708597
SGTC_1005 4092-0690 4.4 µM -2.30508886390634 0.027658896471465 no 3233 0.0105807985247497 1077 1529343
SGTC_674 0498-0004 451 µM -2.30854720070113 0.027490297221356 no 3234 0.0104843603660367 1043 4231473
SGTC_2387 9077560 195.08 µM -2.30967811558161 0.0274353496375454 no 3235 0.0104529906403873 1067 5303272
SGTC_1952 st077036 64.1 µM -2.31446479522441 0.0272037931227133 no 3236 0.0103211201018198 1065 2937007
SGTC_213 1246-0773 967 nM -2.32665823545978 0.0266212906810434 no 3237 0.00999173118889648 1075 6251622
SGTC_2313 7726885 200 µM -2.33083138784272 0.0264243403479195 no 3238 0.00988112616924061 1071 726423
SGTC_3069 9117009 49.47 µM -2.33324158038115 0.0263111479880597 no 3239 0.00981773482194019 1078 41904981
SGTC_350 k064-0020 19.8 µM -2.33901336991332 0.0260417281316769 no 3240 0.00966737077706062 1042 2790705
SGTC_1560 lithocholic acid 53.1 µM -2.35569779855223 0.0252758660205325 no 3241 0.00924397566932362 1067 9903 A bile acid which acts as a detergent.
SGTC_743 1275-0778 158 µM -2.3569529943014 0.0252190203160489 no 3242 0.00921278952532535 1062 2849257 YMR203W TOM40
SGTC_2700 st077718 96.8 µM -2.35888467305724 0.0251317471540021 no 3243 0.00916497563030219 1083 904970
SGTC_1917 st066507 28.5 µM -2.36041768401539 0.02506266607142 no 3244 0.00912718451239801 1054 3156428
SGTC_2007 4011539 71.82 µM -2.36279828581592 0.0249557061050721 no 3245 0.00906876937825805 1065 45595301
SGTC_3319 9138450 16.7555 µM -2.36426416368023 0.0248900350953015 no 3246 0.00903296280385782 1067 2029690
SGTC_2819 7996655 46.38 µM -2.36904045944825 0.0246770626458511 no 3247 0.00891715119150617 1070 6456960
SGTC_1211 1056-0033 32.3 µM -2.37436251662804 0.0244415580425577 no 3248 0.00878964076389879 1070 6741922
SGTC_1656 st012921 11 µM -2.37660749306031 0.0243427836274273 no 3249 0.00873633479882885 1076 6732821
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -2.3859580064605 0.0239349778459865 no 3250 0.0085173480448072 1081 676296 Flavone; oxidizing agent.
SGTC_2698 st077697 67.5 µM -2.38910014883292 0.0237992343396645 no 3251 0.00844484881180341 1085 3154499
SGTC_1423 4048-0112 5.59 µM -2.40144895963613 0.0232720078304874 no 3252 0.00816514352046005 1086 X1423
SGTC_2999 9069765 71.4286 µM -2.40455415698702 0.0231409906892219 no 3253 0.00809610340689086 1073 2097066
SGTC_768 0384-0033 77.3 µM -2.42594963870183 0.022255033001149 no 3254 0.00763419443883584 1072 3965305 YMR134W ERG29
SGTC_591 4299-0174 154 µM -2.44833685056402 0.0213588212480493 no 3255 0.0071758705136783 1085 5509088
SGTC_1133 3473-0247 50 µM -2.45462197983858 0.0211127685446019 no 3256 0.0070516403826989 1058 711311
SGTC_2784 7567673 72.73 µM -2.46704599253916 0.0206334393334942 no 3257 0.00681164290459523 1069 3471247
SGTC_3284 9108171 64.8615 µM -2.48548750442482 0.019938963904486 no 3258 0.0064687064509181 1071 8687505
SGTC_403 arphamenine a 50 µM -2.48826048121477 0.0198362733377169 no 3259 0.00641848367258867 1075 5487158 An arginine aminopeptidase inhibitor.
SGTC_883 0850-0245 24.6 µM -2.50331151541527 0.019286691589426 no 3260 0.0061518598043587 1080 6823229 YPR165W RHO1
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -2.52355571209381 0.0185679342052662 no 3261 0.00580873252841121 1083 803109
SGTC_151 3013-0144 2.285 µM -2.55070204125867 0.0176400133218959 no 3262 0.00537530957841155 1071 906558 YHR107C CDC12
SGTC_562 3772-2733 112 µM -2.56374167216123 0.017208548586504 no 3263 0.00517752915777129 1082 2876874 YIL048W NEO1
SGTC_2916 7875993 68.79 µM -2.59070702136322 0.0163448378204841 no 3264 0.00478894969586684 1078 1299250
SGTC_1310 1188-0297 994 nM -2.61006905226969 0.0157478042728711 no 3265 0.00452619739816132 1056 1588352
SGTC_1974 st069448 26.9 µM -2.61548942353468 0.0155840548551588 no 3266 0.00445498403271232 1081 6323587 YNR016C ACC1
SGTC_2167 5876490 200 µM -2.62717718598542 0.0152359336173891 no 3267 0.00430482448699683 1084 686534
SGTC_2867 9039098 71.43 µM -2.62834166697502 0.0152016181868339 no 3268 0.00429011441008767 1070 6463460
SGTC_2722 naftopidil 47.16 µM -2.6365728520508 0.0149609461708823 no 3269 0.00418741073786976 1078 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2161 5662504 8.5105 µM -2.64190218912812 0.0148068744669565 no 3270 0.00412209302095745 1068 2859334
SGTC_2482 5981709 142.65 µM -2.6757522543055 0.0138597732727733 no 3271 0.00372808695435186 1079 877755
SGTC_3244 9134489 49.47 µM -2.68302934934187 0.0136631305336364 no 3272 0.00364792936253734 1088 16584271
SGTC_3076 9116187 49.47 µM -2.68576171369359 0.0135899202986951 no 3273 0.00361823383968387 1084 27241210
SGTC_2629 bisabolol 100 µM -2.69344414442923 0.0133858907129259 no 3274 0.0035358996773219 1078 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_3266 9136860 49.47 µM -2.70560666915394 0.0130682880272745 no 3275 0.00340898738096985 1064 4871271 YPR165W RHO1
SGTC_1632 st005650 90 µM -2.72554821208054 0.012561640748271 no 3276 0.00320974001805937 1085 2759605
SGTC_2546 rhodinyl acetate 100 µM -2.7274127972058 0.0125151490495755 no 3277 0.00319165636684854 1076 6708682
SGTC_2720 fluspirilene 36.88 µM -2.7395109718518 0.0122170964000816 no 3278 0.00307653305136085 1085 3396 An atypical antipsychotic.
SGTC_2490 carminic acid 95.39 µM -2.74119613958532 0.0121760723315632 no 3279 0.00306079763777203 1086 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_1282 0886-0010 32.4 µM -2.74616411435444 0.012055825015993 no 3280 0.00301482964223819 1080 2836211 YNL267W PIK1
SGTC_1772 st048439 82.2 µM -2.76544432127292 0.0115988573680049 no 3281 0.00284226542198703 1082 2927068 YDL195W SEC31
SGTC_2949 9072542 2.23 µM -2.77246343051248 0.0114362693661632 no 3282 0.00278168850154415 1084 16457352
SGTC_2188 6126565 140.678 µM -2.81297275425444 0.0105360798499007 no 3283 0.00245429050186149 1091 874518
SGTC_2286 7945697 125 µM -2.81934915969226 0.0104001592728082 no 3284 0.00240605710090538 1075 1245733
SGTC_969 1313-0238 134 µM -2.82346632586973 0.0103132113247811 no 3285 0.00237537081191913 1076 5212874
SGTC_558 k064-0027 21.3 µM -2.84683127810852 0.00983168757009209 no 3286 0.00220783793767165 1092 5088526
SGTC_669 0108-0021 26.2 µM -2.85291071990375 0.00970966317861657 no 3287 0.00216603953022614 1076 17201
SGTC_1283 0922-0125 16.4 µM -2.91388333389151 0.00855720551543876 no 3288 0.00178481640936618 1085 3360884
SGTC_2106 5357045 167.29 µM -2.93138998377053 0.00824930485598653 no 3289 0.00168724433451595 1092 668842
SGTC_1385 3091-4834 14.1 µM -2.93780816754634 0.00813888636202209 no 3290 0.00165270740681124 1090 4072814
SGTC_2065 5221596 34.26 µM -2.94223649883743 0.00806346047542281 no 3291 0.00162925483500239 1089 788581
SGTC_2855 9016525 58.44 µM -2.95554940730476 0.00784039475320416 no 3292 0.00156056351266002 1082 43811474
SGTC_470 aa-861 153 µM -2.97678886785293 0.00749574618494458 no 3293 0.00145642264937012 1090 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_2781 5567276 71.43 µM -2.98386739620288 0.00738388686263808 no 3294 0.00142315047841384 1084 2853274
SGTC_3141 9094609 49.47 µM -2.99735890556159 0.00717475345995046 no 3295 0.00136164944158545 1074 25236309 YDL196W YDL196W
SGTC_3059 1327-0034 3 µM -3.00101639560571 0.00711896613392248 no 3296 0.00134540038172616 1088 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_699 0375-0592 111 µM -3.0059015522324 0.00704505044007528 no 3297 0.00132397356693908 1090 762578
SGTC_1353 1498-1206 8.11 µM -3.01359175233435 0.00693006453019682 no 3298 0.00129087480255818 1014 6756808
SGTC_3304 9125678 46.087 µM -3.02322195687363 0.00678841007381357 no 3299 0.00125049367312765 1087 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_2046 4110841 106 µM -3.04024515261534 0.0065442573355524 no 3300 0.00118192825176963 1092 44119630 YMR134W ERG29
SGTC_505 gw-5074 63.9 µM -3.07284199329565 0.00609832659188952 no 3301 0.0010601536134741 1089 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_1469 k284-2957 126 µM -3.10294809201362 0.0057106076841037 no 3302 0.000958016218874643 1060 23884841
SGTC_1982 st072467 71.9 µM -3.10648158429777 0.00566656802776285 no 3303 0.000946640503822651 1094 3163533
SGTC_2036 5160441 105 µM -3.12601426703039 0.00542852037984216 no 3304 0.000885964775806949 1083 134534 YIL048W NEO1
SGTC_326 k292-0812 17.5 µM -3.17132183048847 0.00491025018813496 no 3305 0.000758734615386682 1091 3579357
SGTC_1773 st048542 73.5835 µM -3.21606958635642 0.00444213341127165 no 3306 0.000649796578728405 1092 3237138
SGTC_628 1636-0253 16 µM -3.21936191687235 0.00440931999356702 no 3307 0.000642381101608721 1087 4456143
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -3.26216896020769 0.00400196571782427 no 3308 0.000552816116962579 1079 1377
SGTC_2038 4100038 30.985 µM -3.26983475288129 0.00393268355443581 no 3309 0.000538051637304182 1076 3596803
SGTC_2717 st081029 62.2815 µM -3.28210189722382 0.0038240485170886 no 3310 0.000515181819795835 1092 5292846
SGTC_402 epigallocatechin gallate 10 µM -3.31394314472174 0.00355451490730852 no 3311 0.000459951051180117 1088 65064 An antioxidant.
SGTC_2536 dehydroabietamide 32.04 µM -3.33600388912738 0.00337790572848566 no 3312 0.000424959873892026 1092 3983547
SGTC_2905 7799065 20.05 µM -3.39148172481779 0.00296811715624719 no 3313 0.000347578994821665 1072 1296806
SGTC_2896 9052656 71.43 µM -3.41518389020478 0.00280713340858584 no 3314 0.000318694823009943 1075 6469436
SGTC_2980 9014342 25.29 µM -3.41710732848256 0.00279442160720368 no 3315 0.000316451614228255 1073 2996599
SGTC_1785 bathophenanthroline 24 µM -3.4231882727898 0.00275457422796894 no 3316 0.000309455969762731 1063 72812 An iron chelator.
SGTC_1568 digitonin 820 nM -3.42531851623639 0.00274073686795555 no 3317 0.000307039520088459 1078 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_453 enantio-paf c16 10 µM -3.48479791302891 0.00237884329464028 no 3318 0.000246254429243069 1084 13871343 A lipid and platelet activating factor
SGTC_2389 9091542 195.52 µM -3.50822679545966 0.00224859088879524 no 3319 0.000225552152095163 1093 3626624 YOL127W RPL25
SGTC_2484 5809818 12.04 µM -3.53805933360914 0.00209210025432845 no 3320 0.000201539735580693 1092 2870548
SGTC_1209 2323-2347 50.3 µM -3.56738869633016 0.00194794680918852 no 3321 0.000180278224726478 1090 5412760
SGTC_263 alizarin 107.927 µM -3.58359866515224 0.00187220399830083 no 3322 0.000169446333861075 1086 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_1524 corynanthine 62.1 µM -3.67229398879474 0.00150315539709483 no 3323 0.000120191458015611 1092 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_1000 4048-0884 8.67 µM -3.69982643776032 0.00140289485562015 no 3324 0.000107873482969849 1093 13040088
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -3.75325437900972 0.00122555974504522 no 3325 8.72767807011871e-05 1092 2374 Ca(2+)-ATPase inhibitor.
SGTC_1377 2944-0135 198 µM -3.78709224452257 0.00112411641476952 no 3326 7.62102631398766e-05 1089 1894137
SGTC_1330 1469-0054 61.8 µM -3.84396973063222 0.000970784648606885 yes 3327 6.05299721668233e-05 1090 7102664
SGTC_435 c-PAF 6.7 µM -3.91413964661214 0.000808135359496397 yes 3328 4.53635598189207e-05 1086 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_2586 curcumin 80 µM -3.92938257737845 0.00077629782975846 yes 3329 4.25821256402213e-05 1094 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_3302 9125395 16.351 µM -3.96054810497285 0.000714768196837952 yes 3330 3.73889632515106e-05 1092 17599668
SGTC_2275 7947463 200 µM -4.01087955728133 0.000624820490227976 yes 3331 3.02464829759508e-05 1092 1225414
SGTC_1798 st045719 60.953 µM -4.04253241505913 0.00057373377031981 yes 3332 2.64384999527345e-05 1092 3980186
SGTC_2997 9067075 71.4286 µM -4.08702683721828 0.000508427886958447 yes 3333 2.18468296385794e-05 1090 27209819
SGTC_2612 dictamnine 15.46 µM -4.15178648342846 0.000425593047325883 yes 3334 1.64944985496371e-05 1087 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_3142 9086498 49.47 µM -4.17938977114276 0.000394245574709447 yes 3335 1.46146175548003e-05 1085 25236367
SGTC_2986 9022445 71.43 µM -4.22823969512947 0.00034396417115319 yes 3336 1.17763400393683e-05 1093 6459286
SGTC_2021 4019055 173 µM -4.25842632869688 0.000315943845636295 yes 3337 1.02935521629589e-05 1093 44827708 YER133W GLC7
SGTC_2322 7413319 38.22 µM -4.29194706122543 0.000287324651899126 yes 3338 8.85565901714467e-06 1091 1840400
SGTC_513 4245-1575 41.7 µM -4.31263618316073 0.000270885529765996 yes 3339 8.065972751472e-06 1093 719745
SGTC_1999 st074831 12.5 µM -4.46203068735109 0.00017577247373869 yes 3340 4.05932979101758e-06 1094 17112523
SGTC_394 menadione 8.33 µM -4.58716344919204 0.000121187738396512 yes 3341 2.24654455692406e-06 1092 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_3243 9134147 49.47 µM -4.75018186083115 7.36829349927618e-05 yes 3342 1.01616896714816e-06 1092 24282180
SGTC_2836 9010338 19.48 µM -5.13761006728424 2.12719228849242e-05 yes 3343 1.39127248243364e-07 1095 2994051
SGTC_2858 9025781 8.96 µM -5.14572743567452 2.07066286314587e-05 yes 3344 1.3324305822307e-07 1091 4894980 YPL153C RAD53
SGTC_1347 1493-0251 600 nM -5.14729054598003 2.05994229872722e-05 yes 3345 1.32137915105256e-07 1085 3986378
SGTC_2993 9054257 71.4286 µM -5.48385833305725 6.52367099829335e-06 yes 3346 2.0807403477411e-08 1095 6470217 YGL055W OLE1
SGTC_1959 st077091 55.8 µM -5.48393026311779 6.52202341813671e-06 yes 3347 2.07989403569005e-08 1095 821356 YKL052C ASK1
SGTC_1340 1486-1359 257 µM -5.51155065585351 5.91787591703381e-06 yes 3348 1.77843013792809e-08 1094 4309068
SGTC_444 curcumin 90.4 µM -6.21408086537982 4.31621633842386e-07 yes 3349 2.58129690125919e-10 1095 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_457 grayanotoxin iii 135 µM -7.04429817639698 1.3602508125617e-08 yes 3350 9.31993022019073e-13 1092 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_2541 muurolladie-3-one 83.07 µM -7.58301013081307 1.16791719064871e-09 yes 3351 1.68814235799249e-14 1095 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40